Nonuniform discharge currents in active plasma lenses

NASA Astrophysics Data System (ADS)

van Tilborg, J.; Barber, S. K.; Tsai, H.-E.; Swanson, K. K.; Steinke, S.; Geddes, C. G. R.; Gonsalves, A. J.; Schroeder, C. B.; Esarey, E.; Bulanov, S. S.; Bobrova, N. A.; Sasorov, P. V.; Leemans, W. P.

2017-03-01

Active plasma lenses have attracted interest in novel accelerator applications due to their ability to provide large-field-gradient (short focal length), tunable, and radially symmetric focusing for charged particle beams. However, if the discharge current is not flowing uniformly as a function of radius, one can expect a radially varying field gradient as well as potential emittance degradation. We have investigated this experimentally for a 1-mm-diameter active plasma lens. The measured near-axis field gradient is approximately 35% larger than expected for a uniform current distribution, and at overfocusing currents ring-shaped electron beams are observed. These observations are explained by simulations.

Spike train generation and current-to-frequency conversion in silicon diodes

NASA Technical Reports Server (NTRS)

Coon, D. D.; Perera, A. G. U.

1989-01-01

A device physics model is developed to analyze spontaneous neuron-like spike train generation in current driven silicon p(+)-n-n(+) devices in cryogenic environments. The model is shown to explain the very high dynamic range (0 to the 7th) current-to-frequency conversion and experimental features of the spike train frequency as a function of input current. The devices are interesting components for implementation of parallel asynchronous processing adjacent to cryogenically cooled focal planes because of their extremely low current and power requirements, their electronic simplicity, and their pulse coding capability, and could be used to form the hardware basis for neural networks which employ biologically plausible means of information coding.

Study of reflection gratings recorded in polyvinyl alcohol/acrylamide-based photopolymer.

PubMed

Fuentes, Rosa; Fernández, Elena; García, Celia; Beléndez, Augusto; Pascual, Inmaculada

2009-12-01

High-spatial-frequency fringes associated with reflection holographic optical elements are difficult to obtain with currently available recording materials. In this work, holographic reflection gratings were stored in a polyvinyl alcohol/acrylamide photopolymer. This material is formed of acrylamide photopolymer, which is considered interesting material for optical storage applications such as holographic memories. The experimental procedure for examining the high-spatial-frequency response of this material is explained, and the experimental results obtained are presented. With the aim of obtaining the best results, the performance of different material compositions is compared.

Roadmap to clinical use of gold nanoparticles for radiosensitization

PubMed Central

Schuemann, J.; Berbeco, R.; Chithrani, B. D.; Cho, S.; Kumar, R.; McMahon, S.; Sridhar, S.; Krishnan, S.

2015-01-01

The past decade has seen a dramatic increase in interest in the use of Gold Nanoparticles (GNPs) as radiation sensitizers for radiotherapy. This interest was initially driven by their strong absorption of ionizing radiation and the resulting ability to increase dose deposited within target volumes even at relatively low concentrations. These early observations are supported by extensive experimental validation, showing GNPs’ efficacy at sensitizing tumors in both in vitro and in vivo systems to a range of types of ionizing radiation, including kilovoltage and megavoltage X-rays as well as charged particles. Despite this experimental validation, there has been limited translation of GNP-mediated radiosensitization to a clinical setting. One of the key challenges in this area is the wide range of experimental systems that have been investigated, spanning a range of particle sizes, shapes and preparations. As a result, mechanisms of uptake and radiosensitization have remained difficult to clearly identify. This has proven a significant impediment to the identification of optimal GNP formulations which strike a balance among their radiosensitizing properties, their specificity to the tumors, their biocompatibility, and their imageability in vivo. This white paper reviews the current state of knowledge in each of the areas concerning the use of GNPs as radiosensitizers, and outlines the steps which will be required to advance GNP-enhanced radiation therapy from their current pre-clinical setting to clinical trials and eventual routine usage. PMID:26700713

Gaseous Sulfate Solubility in Glass: Experimental Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bliss, Mary

2013-11-30

Sulfate solubility in glass is a key parameter in many commercial glasses and nuclear waste glasses. This report summarizes key publications specific to sulfate solubility experimental methods and the underlying physical chemistry calculations. The published methods and experimental data are used to verify the calculations in this report and are expanded to a range of current technical interest. The calculations and experimental methods described in this report will guide several experiments on sulfate solubility and saturation for the Hanford Waste Treatment Plant Enhanced Waste Glass Models effort. There are several tables of sulfate gas equilibrium values at high temperature tomore » guide experimental gas mixing and to achieve desired SO3 levels. This report also describes the necessary equipment and best practices to perform sulfate saturation experiments for molten glasses. Results and findings will be published when experimental work is finished and this report is validated from the data obtained.« less

Search for a Neutron Electric Dipole Moment

PubMed Central

Golub, R.; Huffman, P. R.

2005-01-01

The possible existence of a nonzero electric dipole moment (EDM) of the neutron is of great fundamental interest in itself and directly impacts our understanding of the nature of electro-weak and strong interactions. The experimental search for this moment has the potential to reveal new sources of T and CP violation and to challenge calculations that propose extensions to the Standard Model. The goal of the current experiment is to significantly improve the measurement sensitivity to the neutron EDM over what is reported in the literature. The experiment has the potential to either measure the magnitude of the neutron EDM or to lower the current experimental limit by two orders of magnitude. Achieving these objectives will have a major impact on our understanding of the physics of both weak and strong interactions. PMID:27308116

Experimental results on chiral magnetic and vortical effects

DOE PAGES

Wang, Gang; Wen, Liwen

2017-01-12

Various novel transport phenomena in chiral systems result from the interplay of quantum anomalies with magnetic field and vorticity in high-energy heavy-ion collisions and could survive the expansion of the fireball and be detected in experiments. Among them are the chiral magnetic effect, the chiral vortical effect, and the chiral magnetic wave, the experimental searches for which have aroused extensive interest. As a result, the goal of this review is to describe the current status of experimental studies at Relativistic Heavy-Ion Collider at BNL and the Large Hadron Collider at CERN and to outline the future work in experiment neededmore » to eliminate the existing uncertainties in the interpretation of the data.« less

Written Composition Process, Evaluation Difficulties and Modalities: An Experimental Study

ERIC Educational Resources Information Center

Rodriguez, Celestino; Garci, Jesus Nicasio; Gonzalez-Castro, Paloma; Alvarez, David; Cerezo, Rebeca; Bernardo, Ana

2011-01-01

The underlying processes used in written compositions are currently a very interesting subject. Participants in this study were 326 people between 10 and 16 years of age, divided into two groups and compared by means of a "writing log". One group was provided assistance in the writing task by means of a graphic organiser, whilst the other was not…

Pyrolysis Products Of Dimethyldichlorosilane

NASA Technical Reports Server (NTRS)

Cagliostro, D. E.; Riccitiello, S. R.; Carswell, M. G.

1990-01-01

Report describes experimental study of chemical reactions and chemical products of chemical-vapor deposition of silicon carbide from dimethyldichlorosilane. Topic important because it relates to current interest in lightweight refractory materials for use in advanced aircraft and spacecraft. Analyses showed that at temperature of 700 to 1,100 degrees C and contact time of about 1 minute, SiC forms by two chemical-reaction paths.

Biology: A Secondary School Syllabus with Major Emphasis on Fundamental Concepts. 1976 Reprint.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of General Education Curriculum Development.

This syllabus, which has evolved from the New York State Experimental Biology program, includes a basic core and six optional extended areas designed to be interesting and meaningful to the types of students currently taking the Regents Examination in Biology. The seven core unit topics are: (1) The Study of Life; (2) Maintenance in Animals; (3)…

Magnetically coupled magnet-spring oscillators

NASA Astrophysics Data System (ADS)

Donoso, G.; Ladera, C. L.; Martín, P.

2010-05-01

A system of two magnets hung from two vertical springs and oscillating in the hollows of a pair of coils connected in series is a new, interesting and useful example of coupled oscillators. The electromagnetically coupled oscillations of these oscillators are experimentally and theoretically studied. Its coupling is electromagnetic instead of mechanical, and easily adjustable by the experimenter. The coupling of this new coupled oscillator system is determined by the currents that the magnets induce in two coils connected in series, one to each magnet. It is an interesting case of mechanical oscillators with field-driven coupling, instead of mechanical coupling. Moreover, it is both a coupled and a damped oscillating system that lends itself to a detailed study and presentation of many properties and phenomena of such a system of oscillators. A set of experiments that validates the theoretical model of the oscillators is presented and discussed.

Investigating electrical resonance in eddy-current array probes

NASA Astrophysics Data System (ADS)

Hughes, R.; Fan, Y.; Dixon, S.

2016-02-01

The sensitivity enhancing effects of eddy-current testing at frequencies close to electrical resonance are explored. Var-ied techniques exploiting the phenomenon, dubbed near electrical resonance signal enhancement (NERSE), were experimentally investigated to evaluate its potential exploitation for other interesting applications in aerospace materials, in particular its potential for boosting the sensitivity of standard ECT measurements. Methods for setting and controlling the typically unstable resonant frequencies of such systems are discussed. This research is funded by the EPSRC, via the Research Centre for Non-Destructive Evaluation RCNDE, and Rolls-Royce plc.

Modeling the process of interaction of 10 keV electrons with a plane dielectric surface

NASA Astrophysics Data System (ADS)

Vokhmyanina, Kristina; Sotnikova, Valentina; Sotnikov, Alexey; Kaplii, Anna; Nikulicheva, Tatyana; Kubankin, Alexandr; Kishin, Ivan

2018-05-01

The effect of guiding of charged particles by dielectric channels is of noticeable interest at the present time. The phenomenon is widely studied experimentally and theoretically but some points still need to be clarified. A previously developed model of interaction of fast electrons with dielectric surface at grazing incidence is used to study the independence of electron deflection on the value of electron beam current. The calculations were performed assuming a smooth dependence of the surface conductivity on the beam current in the 40-3000 nA range.

Advances in poultry litter disposal technology--a review.

PubMed

Kelleher, B P; Leahy, J J; Henihan, A M; O'Dwyer, T F; Sutton, D; Leahy, M J

2002-05-01

The land disposal of waste from the poultry industry and subsequent environmental implications has stimulated interest into cleaner and more useful disposal options. The review presented here details advances in the three main alternative disposal routes for poultry litter, specifically in the last decade. Results of experimental investigations into the optimisation of composting, anaerobic digestion and direct combustion are summarised. These technologies open up increased opportunities to market the energy and nutrients in poultry litter to agricultural and non-agricultural uses. Common problems experienced by the current technologies are the existence and fate of nitrogen as ammonia, pH and temperature levels, moisture content and the economics of alternative disposal methods. Further advancement of these technologies is currently receiving increased interest, both academically and commercially. However, significant financial incentives are required to attract the agricultural industry.

Classification of DNA nucleotides with transverse tunneling currents

NASA Astrophysics Data System (ADS)

Nyvold Pedersen, Jonas; Boynton, Paul; Di Ventra, Massimiliano; Jauho, Antti-Pekka; Flyvbjerg, Henrik

2017-01-01

It has been theoretically suggested and experimentally demonstrated that fast and low-cost sequencing of DNA, RNA, and peptide molecules might be achieved by passing such molecules between electrodes embedded in a nanochannel. The experimental realization of this scheme faces major challenges, however. In realistic liquid environments, typical currents in tunneling devices are of the order of picoamps. This corresponds to only six electrons per microsecond, and this number affects the integration time required to do current measurements in real experiments. This limits the speed of sequencing, though current fluctuations due to Brownian motion of the molecule average out during the required integration time. Moreover, data acquisition equipment introduces noise, and electronic filters create correlations in time-series data. We discuss how these effects must be included in the analysis of, e.g., the assignment of specific nucleobases to current signals. As the signals from different molecules overlap, unambiguous classification is impossible with a single measurement. We argue that the assignment of molecules to a signal is a standard pattern classification problem and calculation of the error rates is straightforward. The ideas presented here can be extended to other sequencing approaches of current interest.

TMDs and SSAs in hadronic interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aschenauer, E. C.; D’Alesio, U.; Murgia, F.

2016-06-17

Here we present an overview on the current experimental and phenomenological status of transverse single spin asymmetries (tSSAs) in proton-proton collisions. In particular, we focus on large- pT inclusive pion, photon, jet, pion-jet production and Drell-Yan processes. For all of them theoretical estimates are given in terms of a generalised parton model (GPM) based on a transverse momentum dependent (TMD) factorisation scheme. We also make comparisons with the corresponding results in a collinear twist-3 formalism and in a modified GPM approach. On the experimental side, a selection of the most interesting and recent results from RHIC is presented.

[Experimental orthopedic surgery: the practical aspects and management].

PubMed

Di Denia, P; Caligiuri, G; Guzzardella, G A; Fini, M; Giardino, R

1996-01-01

The funds to grant for a scientific research project are more and more interesting public and private administrations. A quantitative analysis of experimental research prices in all its phases is mandatory for an optimization process. The aim of this paper is to define practical and economical aspects of the experimental 'in vivo' models designed for the validation of biomaterials, with particular respect to the managerial bookkeeping of consumer goods, based on the experience of our Institute. Some tables were realized in order to quantify the resources needed to perform experimental 'in vivo' models. These tables represent a reliable tool for a continuous monitoring of managerial costs for the current year and for an accurate budget planning for the future years considering the experimental projects in progress and the planned researches. A business organization of public research facilities may lead to an optimization of costs and an easier national and international funds achievement increasing, also, the partnership with private appointers.

Measurement Techniques of the Magneto-Electric Coupling in Multiferroics

PubMed Central

Fetisov, Y. K.; Caruntu, G.; Srinivasan, G.

2017-01-01

The current surge of interest in multiferroic materials demands specialized measurement techniques to support multiferroics research. In this review article we detail well-established measurement techniques of the magneto-electric coupling coefficient in multiferroic materials, together with newly proposed ones. This work is intended to serve as a reference document for anyone willing to develop experimental measurement techniques of multiferroic materials. PMID:28817089

[Adjuvants in modern anesthesia - magnesium].

PubMed

Picardi, Susanne; Lirk, Philipp; Blobner, Manfred; Schönherr, Marianne E; Hollmann, Markus W

2015-06-01

Magnesium plays a key role in many cellular functions and there is growing interest in its role in perioperative medicine. While experimental studies provided promising results for several disease states, clinical trials mainly gave conflicting results. This review article summarizes current knowledge on the homeostasis of magnesium as well as on its proposed indications and recommendations in the clinical setting. © Georg Thieme Verlag Stuttgart · New York.

ATLAS experimental equipment. November 1983 workshop and present status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1984-01-01

The latest workshop was held in November 1983 with the purpose of presenting an overview of the experimental stations planned for ATLAS, describing the current status of each individual apparatus, soliciting final input on devices of the first phase (i.e. on those that will be ready when beams from ATLAS become available in late Spring of 1985), and discussing and collecting new ideas on equipment for the second phase. There were short presentations on the status of the various projects followed by informal discussions. The presentations mainly concentrated on new equipment for target area III, but included some descriptions ofmore » current apparatus in target area II that might also be of interest for experiments with the higher-energy beams available in area III. The meeting was well attended with approx. 50 scientists, approximately half of them from institutions outside Argonne. The present proceedings summarize the presentations and discussions of this one-day meeting. In addition we take the opportunity to include information about developments since this meeting and an update of the current status of the various experimental stations. We would like to emphasize again that outside-user input is extremely welcome.« less

Experimental Guidance for Isospin Symmetry Breaking Calculations via Single Neutron Pickup Reactions

NASA Astrophysics Data System (ADS)

Leach, K. G.; Garrett, P. E.; Bangay, J. C.; Bianco, L.; Demand, G. A.; Finlay, P.; Green, K. L.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wong, J.; Ball, G.; Faestermann, T.; Krücken, R.; Hertenberger, R.; Wirth, H.-F.; Towner, I. S.

2013-03-01

Recent activity in superallowed isospin-symmetry-breaking correction calculations has prompted interest in experimental confirmation of these calculation techniques. The shellmodel set of Towner and Hardy (2008) include the opening of specific core orbitals that were previously frozen. This has resulted in significant shifts in some of the δC values, and an improved agreement of the individual corrected {F}t values with the adopted world average of the 13 cases currently included in the high-precision evaluation of Vud. While the nucleus-to-nucleus variation of {F}t is consistent with the conserved-vector-current (CVC) hypothesis of the Standard Model, these new calculations must be thoroughly tested, and guidance must be given for their improvement. Presented here are details of a 64Zn(ěcd, t)63Zn experiment, undertaken to provide such guidance.

Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schuemann, Jan, E-mail: jschuemann@mgh.harvard.edu; Berbeco, Ross; Chithrani, Devika B.

2016-01-01

The past decade has seen a dramatic increase in interest in the use of gold nanoparticles (GNPs) as radiation sensitizers for radiation therapy. This interest was initially driven by their strong absorption of ionizing radiation and the resulting ability to increase dose deposited within target volumes even at relatively low concentrations. These early observations are supported by extensive experimental validation, showing GNPs' efficacy at sensitizing tumors in both in vitro and in vivo systems to a range of types of ionizing radiation, including kilovoltage and megavoltage X rays as well as charged particles. Despite this experimental validation, there has been limited translationmore » of GNP-mediated radiation sensitization to a clinical setting. One of the key challenges in this area is the wide range of experimental systems that have been investigated, spanning a range of particle sizes, shapes, and preparations. As a result, mechanisms of uptake and radiation sensitization have remained difficult to clearly identify. This has proven a significant impediment to the identification of optimal GNP formulations which strike a balance among their radiation sensitizing properties, their specificity to the tumors, their biocompatibility, and their imageability in vivo. This white paper reviews the current state of knowledge in each of the areas concerning the use of GNPs as radiosensitizers, and outlines the steps which will be required to advance GNP-enhanced radiation therapy from their current pre-clinical setting to clinical trials and eventual routine usage.« less

Ten years of PCV2 vaccines and vaccination: Is eradication a possibility?

PubMed

Afghah, Zahra; Webb, Brett; Meng, Xiang-Jin; Ramamoorthy, Sheela

2017-07-01

More than two decades after its emergence, porcine circovirus type 2 (PCV2) remains an economically important swine pathogen. Commercial vaccines which were first introduced to the U.S in 2006, have been highly effective in reducing clinical signs and improving production. Recent studies have indicated a declining level of PCV2 prevalence and viremia in the field. However, reports on the emergence of new viral variants have also continued to increase. This article reviews topics of current interest in the field of PCV2 vaccines; including the comparative efficacy of the available commercial products, efficacy of current vaccines against new and emerging strains, findings on the differences between immunity in natural infection versus vaccination, limitations of current experimental models for PCV2 vaccine studies, and new developments in novel experimental vaccines. The discussion is framed in the context of attempts for the possible eradication of PCV2 in the future. Copyright © 2016 Elsevier B.V. All rights reserved.

Current driven instabilities of an electromagnetically accelerated plasma

NASA Technical Reports Server (NTRS)

Chouetri, E. Y.; Kelly, A. J.; Jahn, R. G.

1988-01-01

A plasma instability that strongly influences the efficiency and lifetime of electromagnetic plasma accelerators was quantitatively measured. Experimental measurements of dispersion relations (wave phase velocities), spatial growth rates, and stability boundaries are reported. The measured critical wave parameters are in excellent agreement with theoretical instability boundary predictions. The instability is current driven and affects a wide spectrum of longitudinal (electrostatic) oscillations. Current driven instabilities, which are intrinsic to the high-current-carrying magnetized plasma of the magnetoplasmadynmic (MPD) accelerator, were investigated with a kinetic theoretical model based on first principles. Analytical limits of the appropriate dispersion relation yield unstable ion acoustic waves for T(i)/T(e) much less than 1 and electron acoustic waves for T(i)/T(e) much greater than 1. The resulting set of nonlinear equations for the case of T(i)/T(e) = 1, of most interest to the MPD thruster Plasma Wave Experiment, was numerically solved to yield a multiparameter set of stability boundaries. Under certain conditions, marginally stable waves traveling almost perpendicular to the magnetic field would travel at a velocity equal to that of the electron current. Such waves were termed current waves. Unstable current waves near the upper stability boundary were observed experimentally and are in accordance with theoretical predictions. This provides unambiguous proof of the existence of such instabilites in electromagnetic plasma accelerators.

Therapeutic Manuka Honey: No Longer So Alternative

PubMed Central

Carter, Dee A.; Blair, Shona E.; Cokcetin, Nural N.; Bouzo, Daniel; Brooks, Peter; Schothauer, Ralf; Harry, Elizabeth J.

2016-01-01

Medicinal honey research is undergoing a substantial renaissance. From a folklore remedy largely dismissed by mainstream medicine as “alternative”, we now see increased interest by scientists, clinical practitioners and the general public in the therapeutic uses of honey. There are a number of drivers of this interest: first, the rise in antibiotic resistance by many bacterial pathogens has prompted interest in developing and using novel antibacterials; second, an increasing number of reliable studies and case reports have demonstrated that certain honeys are very effective wound treatments; third, therapeutic honey commands a premium price, and the honey industry is actively promoting studies that will allow it to capitalize on this; and finally, the very complex and rather unpredictable nature of honey provides an attractive challenge for laboratory scientists. In this paper we review manuka honey research, from observational studies on its antimicrobial effects through to current experimental and mechanistic work that aims to take honey into mainstream medicine. We outline current gaps and remaining controversies in our knowledge of how honey acts, and suggest new studies that could make honey a no longer “alternative” alternative. PMID:27148246

Atomic Data Needs for X-Ray Astronomy

NASA Technical Reports Server (NTRS)

Kallman, Timothy; White, Nicholas E. (Technical Monitor)

1999-01-01

This publication contains written versions of most of the invited talks presented at the workshop on Atomic Data Needs for X-ray Astronomy which was held at NASA's Goddard Space Flight Center on December 16-1 7 1999. The idea of hosting such a workshop emerged from an imminent need to update and complete current atomic datasets in anticipation of a new era of high quality X-ray spectra starting with the launching of Chandra and XMM-Newton observatories. At first, our vision of the workshop was of a short and limited attendance event, given the specialization of the topic. But it, was soon realized, from the response to the first workshop announcement, that the topic was of much interest, to researchers working in X-ray spectra (physicists and astronomers). As a result, the workshop grew to approximately 120 participants from several countries. The kind of atomic data that interests us are those parameters needed for analysis and modeling of spectra shortward of about about 100 A and relevant to ionic species of astronomical interest. The physical mechanisms of interest in the formation of spectra include photoionization. collisional ionization, recombination (radiative and dielectronic). collisional excitation (by electrons and protons). and radiative deexcitation. Unique to X-ray spectroscopy are the ionization and excitation processes from inner-closed shells. in addition to the challenges in interpret,ing the medium resolution (epsilon/delta epsilon is about 0.05 - 0.1) data obtained by current X-ray astronomy experiments. Line wavelengths are of interest too, particularly owing to the high resolution spectra from the new experiments. The workshop was divided into five major areas: Observational Spectroscopy, Theoretical Calculations of Atomic Data, Laboratory Measurements of Atomic Parameters. Spectra Modeling, and Atomic Databases. One comforting finding from the work shop is that the enthusiasm felt by X-ray astronomers about the new observational missions seems to be shared by theoretical and experimental physicists. Talks were presented about several exciting new projects and experimental and theoretical techniques devoted to X-ray spectroscopy. Simultaneously, several new tools for spectral analysis and modeling have recently been developed, together with improved atomic databases. These proceeding are expected to be of interests to producers and users of atomic data. Moreover. the contributions presented here have been written in a way that can be used by a general audience of scientists and graduate students in X-ray astronomy, modelling, and in computational and experimental atomic physics.

Performance of gigabit FDDI

NASA Technical Reports Server (NTRS)

Game, David; Maly, Kurt J.

1990-01-01

Great interest exists in developing high speed protocols which will be able to support data rates at gigabit speeds. Hardware currently exists which can experimentally transmit at data rates exceeding a gigabit per second, but it is not clear as to what types of protocols will provide the best performance. One possibility is to examine current protocols and their extensibility to these speeds. Scaling of Fiber Distributed Data Interface (FDDI) to gigabit speeds is studied. More specifically, delay statistics are included to provide insight as to which parameters (network length, packet length or number of nodes) have the greatest effect on performance.

An Experimental Study of Social and Psychological Aspects of Teleworking: The Implications for Tele-Education.

ERIC Educational Resources Information Center

Hobbs, Dave; Armstrong, James

The last few years have seen a growth in interest in the concept of distance-learning in the field of education and in the use of teleworking to provide a way of conducting work from home. Current predictions suggest that these could become very significant ways of learning and working in the future. The contention of this paper is that distance…

Neutron flux characterization of californium-252 Neutron Research Facility at the University of Texas - Pan American by nuclear analytical technique

NASA Astrophysics Data System (ADS)

Wahid, Kareem; Sanchez, Patrick; Hannan, Mohammad

2014-03-01

In the field of nuclear science, neutron flux is an intrinsic property of nuclear reaction facilities that is the basis for experimental irradiation calculations and analysis. In the Rio Grande Valley (Texas), the UTPA Neutron Research Facility (NRF) is currently the only neutron facility available for experimental research purposes. The facility is comprised of a 20-microgram californium-252 neutron source surrounded by a shielding cascade containing different irradiation cavities. Thermal and fast neutron flux values for the UTPA NRF have yet to be fully investigated and may be of particular interest to biomedical studies in low neutron dose applications. Though a variety of techniques exist for the characterization of neutron flux, neutron activation analysis (NAA) of metal and nonmetal foils is a commonly utilized experimental method because of its detection sensitivity and availability. The aim of our current investigation is to employ foil activation in the determination of neutron flux values for the UTPA NSRF for further research purposes. Neutron spectrum unfolding of the acquired experimental data via specialized software and subsequent comparison for consistency with computational models lends confidence to the results.

High lying energy positions of doubly (2p ns) 1,3P° and (2p nd) 1,3P° excited states of the beryllium atom

NASA Astrophysics Data System (ADS)

Sakho, I.

2011-12-01

The Screening Constant by Unit Nuclear Charge (SCUNC) method is used to study (2p ns) 1,3P° and (2p nd) 1,3P° autoionizing states of the beryllium atom. Energy positions are reported up to n=20. In addition, resonance widths of the (2p ns) 1P° states also presented. The current results compared very well to available theoretical and experimental literature values up to n=15. The accurate data presented in this work may be of interest for future experimental and theoretical studies in the photoabsorption spectrum of Be.

[Effort-reward imbalance at work and depression: current research evidence].

PubMed

Siegrist, J

2013-01-01

In view of highly prevalent stressful conditions in modern working life, in particular increasing work pressure and job insecurity, it is of interest to know whether specific constellations of an adverse psychosocial work environment increase the risk of depressive disorder among employed people. This contribution gives a short overview of current research evidence based on an internationally established work stress model of effort-reward imbalance. Taken together, results from seven prospective epidemiological investigations demonstrate a two-fold elevated relative risk of incident depressive disorder over a mean observation period of 2.7 years among exposed versus non-exposed employees. Additional findings from experimental and quasi-experimental studies point to robust associations of effort-reward imbalance at work with proinflammatory cytokines and markers of reduced immune competence. These latter markers may indicate potential psychobiological pathways. In conclusion, incorporating this new knowledge into medical treatment and preventive efforts seems well justified.

Research ethics I: Responsible conduct of research (RCR)--historical and contemporary issues pertaining to human and animal experimentation.

PubMed

Horner, Jennifer; Minifie, Fred D

2011-02-01

In this series of articles--Research Ethics I, Research Ethics II, and Research Ethics III--the authors provide a comprehensive review of the 9 core domains for the responsible conduct of research (RCR) as articulated by the Office of Research Integrity. In Research Ethics I, they present a historical overview of the evolution of RCR in the United States then examine the evolution of human and animal experimentation from the birth of scientific medicine through World War II to the present day. They relied on authoritative documents, both historical and contemporary, insightful commentary, and empirical research in order to identify current issues and controversies of potential interest to both faculty and students. The authors have written this article from a historical perspective because they think all readers interested in RCR should appreciate how the history of science and all the good--and harm--it has produced can inform how researchers practice responsible research in the 21st century and beyond.

Molecular photoionization processes of astrophysical and aeronomical interest

NASA Technical Reports Server (NTRS)

Langhoff, P. W.

1985-01-01

An account is given of aspects of photoionization processes in molecules, with particular reference to recent theoretical and experimental studies of partial cross sections for production of specific final electronic states and of parent and fragment ions. Such cross sections help provide a basis for specifying the state of excitation of the ionized medium, are useful for estimating the kinetic energy distributions of photoejected electrons and fragment ions, provide parent-and fragment-ion yields, and clarify the possible origins of neutral fragments in highly excited rovibronic states. A descriptive account is given of photoionization phenomena, including tabulation of valence- and inner-shell potentials for some molecules of astrophysical and aeronomical interest. Cross sectional expressions are given. Various approximations currently employed in computational studies are described briefly, threshold laws and high-energy limits are indicated, and distinction is drawn between resonant and direct photoionization phenomena. Recent experimental and theoretical studies of partial photoionization cross sections in selected compounds of astrophysical and aeronomical relevance are described and discussed.

The divergence characteristics of constrained-sheath optics systems for use with 5-eV atomic oxygen sources

NASA Technical Reports Server (NTRS)

Anderson, John R.; Wilbur, Paul J.

1989-01-01

The potential usefulness of the constrained sheath optics concept as a means of controlling the divergence of low energy, high current density ion beams is examined numerically and experimentally. Numerical results demonstrate that some control of the divergence of typical ion beamlets can be achieved at perveance levels of interest by contouring the surface of the constrained sheath properly. Experimental results demonstrate that a sheath can be constrained by a wire mesh attached to the screen plate of the ion optics system. The numerically predicted beamlet divergence characteristics are shown to depart from those measured experimentally, and additional numerical analysis is used to demonstrate that this departure is probably due to distortions of the sheath caused by the fact that it attempts to conform to the individual wires that make up the sheath constraining mesh. The concept is considered potentially useful in controlling the divergence of ion beamlets in applications where low divergence, low energy, high current density beamlets are being sought, but more work is required to demonstrate this for net beam ion energies as low as 5 eV.

Orbital electron capture by the nucleus

NASA Technical Reports Server (NTRS)

Bambynek, W.; Behrens, H.; Chen, M. H.; Crasemann, B.; Fitzpatrick, M. L.; Ledingham, K. W. D.; Genz, H.; Mutterer, M.; Intemann, R. L.

1976-01-01

The theory of nuclear electron capture is reviewed in the light of current understanding of weak interactions. Experimental methods and results regarding capture probabilities, capture ratios, and EC/Beta(+) ratios are summarized. Radiative electron capture is discussed, including both theory and experiment. Atomic wave function overlap and electron exchange effects are covered, as are atomic transitions that accompany nuclear electron capture. Tables are provided to assist the reader in determining quantities of interest for specific cases.

Nuclear Resonance Fluorescence and Isotopic Mapping of Containers

NASA Astrophysics Data System (ADS)

Johnson, Micah S.; McNabb, Dennis P.

2009-03-01

National security programs have expressed interest in developing systems to isotopically map shipping containers, fuel assemblies, and waste barrels for various materials including special nuclear material (SNM). Current radiographic systems offer little more than an ambiguous density silhouette of a container's contents. In this paper we will present a system being developed at LLNL to isotopically map containers using the nuclear resonance fluorescence (NRF) method. Recent experimental measurements on NRF strengths in SNM are discussed.

Computational Approaches for Revealing the Structure of Membrane Transporters: Case Study on Bilitranslocase.

PubMed

Venko, Katja; Roy Choudhury, A; Novič, Marjana

2017-01-01

The structural and functional details of transmembrane proteins are vastly underexplored, mostly due to experimental difficulties regarding their solubility and stability. Currently, the majority of transmembrane protein structures are still unknown and this present a huge experimental and computational challenge. Nowadays, thanks to X-ray crystallography or NMR spectroscopy over 3000 structures of membrane proteins have been solved, among them only a few hundred unique ones. Due to the vast biological and pharmaceutical interest in the elucidation of the structure and the functional mechanisms of transmembrane proteins, several computational methods have been developed to overcome the experimental gap. If combined with experimental data the computational information enables rapid, low cost and successful predictions of the molecular structure of unsolved proteins. The reliability of the predictions depends on the availability and accuracy of experimental data associated with structural information. In this review, the following methods are proposed for in silico structure elucidation: sequence-dependent predictions of transmembrane regions, predictions of transmembrane helix-helix interactions, helix arrangements in membrane models, and testing their stability with molecular dynamics simulations. We also demonstrate the usage of the computational methods listed above by proposing a model for the molecular structure of the transmembrane protein bilitranslocase. Bilitranslocase is bilirubin membrane transporter, which shares similar tissue distribution and functional properties with some of the members of the Organic Anion Transporter family and is the only member classified in the Bilirubin Transporter Family. Regarding its unique properties, bilitranslocase is a potentially interesting drug target.

Infants' visual and auditory communication when a partner is or is not visually attending.

PubMed

Liszkowski, Ulf; Albrecht, Konstanze; Carpenter, Malinda; Tomasello, Michael

2008-04-01

In the current study we investigated infants' communication in the visual and auditory modalities as a function of the recipient's visual attention. We elicited pointing at interesting events from thirty-two 12-month olds and thirty-two 18-month olds in two conditions: when the recipient either was or was not visually attending to them before and during the point. The main result was that infants initiated more pointing when the recipient's visual attention was on them than when it was not. In addition, when the recipient did not respond by sharing interest in the designated event, infants initiated more repairs (repeated pointing) than when she did, again, especially when the recipient was visually attending to them. Interestingly, accompanying vocalizations were used intentionally and increased in both experimental conditions when the recipient did not share attention and interest. However, there was little evidence that infants used their vocalizations to direct attention to their gestures when the recipient was not attending to them.

Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy

PubMed Central

Tahmasbi, Amir; Ward, E. Sally; Ober, Raimund J.

2015-01-01

Fluorescence microscopy is a photon-limited imaging modality that allows the study of subcellular objects and processes with high specificity. The best possible accuracy (standard deviation) with which an object of interest can be localized when imaged using a fluorescence microscope is typically calculated using the Cramér-Rao lower bound, that is, the inverse of the Fisher information. However, the current approach for the calculation of the best possible localization accuracy relies on an analytical expression for the image of the object. This can pose practical challenges since it is often difficult to find appropriate analytical models for the images of general objects. In this study, we instead develop an approach that directly uses an experimentally collected image set to calculate the best possible localization accuracy for a general subcellular object. In this approach, we fit splines, i.e. smoothly connected piecewise polynomials, to the experimentally collected image set to provide a continuous model of the object, which can then be used for the calculation of the best possible localization accuracy. Due to its practical importance, we investigate in detail the application of the proposed approach in single molecule fluorescence microscopy. In this case, the object of interest is a point source and, therefore, the acquired image set pertains to an experimental point spread function. PMID:25837101

Improving Hall Thruster Plume Simulation through Refined Characterization of Near-field Plasma Properties

NASA Astrophysics Data System (ADS)

Huismann, Tyler D.

Due to the rapidly expanding role of electric propulsion (EP) devices, it is important to evaluate their integration with other spacecraft systems. Specifically, EP device plumes can play a major role in spacecraft integration, and as such, accurate characterization of plume structure bears on mission success. This dissertation addresses issues related to accurate prediction of plume structure in a particular type of EP device, a Hall thruster. This is done in two ways: first, by coupling current plume simulation models with current models that simulate a Hall thruster's internal plasma behavior; second, by improving plume simulation models and thereby increasing physical fidelity. These methods are assessed by comparing simulated results to experimental measurements. Assessment indicates the two methods improve plume modeling capabilities significantly: using far-field ion current density as a metric, these approaches used in conjunction improve agreement with measurements by a factor of 2.5, as compared to previous methods. Based on comparison to experimental measurements, recent computational work on discharge chamber modeling has been largely successful in predicting properties of internal thruster plasmas. This model can provide detailed information on plasma properties at a variety of locations. Frequently, experimental data is not available at many locations that are of interest regarding computational models. Excepting the presence of experimental data, there are limited alternatives for scientifically determining plasma properties that are necessary as inputs into plume simulations. Therefore, this dissertation focuses on coupling current models that simulate internal thruster plasma behavior with plume simulation models. Further, recent experimental work on atom-ion interactions has provided a better understanding of particle collisions within plasmas. This experimental work is used to update collision models in a current plume simulation code. Previous versions of the code assume an unknown dependence between particles' pre-collision velocities and post-collision scattering angles. This dissertation focuses on updating several of these types of collisions by assuming a curve fit based on the measurements of atom-ion interactions, such that previously unknown angular dependences are well-characterized.

Programming experience promotes higher STEM motivation among first-grade girls.

PubMed

Master, Allison; Cheryan, Sapna; Moscatelli, Adriana; Meltzoff, Andrew N

2017-08-01

The gender gap in science, technology, engineering, and math (STEM) engagement is large and persistent. This gap is significantly larger in technological fields such as computer science and engineering than in math and science. Gender gaps begin early; young girls report less interest and self-efficacy in technology compared with boys in elementary school. In the current study (N=96), we assessed 6-year-old children's stereotypes about STEM fields and tested an intervention to develop girls' STEM motivation despite these stereotypes. First-grade children held stereotypes that boys were better than girls at robotics and programming but did not hold these stereotypes about math and science. Girls with stronger stereotypes about robotics and programming reported lower interest and self-efficacy in these domains. We experimentally tested whether positive experience with programming robots would lead to greater interest and self-efficacy among girls despite these stereotypes. Children were randomly assigned either to a treatment group that was given experience in programming a robot using a smartphone or to control groups (no activity or other activity). Girls given programming experience reported higher technology interest and self-efficacy compared with girls without this experience and did not exhibit a significant gender gap relative to boys' interest and self-efficacy. These findings show that children's views mirror current American cultural messages about who excels at computer science and engineering and show the benefit of providing young girls with chances to experience technological activities. Copyright © 2017 Elsevier Inc. All rights reserved.

Experimental Issues in Coherent Quantum-State Manipulation of Trapped Atomic Ions

PubMed Central

Wineland, D. J.; Monroe, C.; Itano, W. M.; Leibfried, D.; King, B. E.; Meekhof, D. M.

1998-01-01

Methods for, and limitations to, the generation of entangled states of trapped atomic ions are examined. As much as possible, state manipulations are described in terms of quantum logic operations since the conditional dynamics implicit in quantum logic is central to the creation of entanglement. Keeping with current interest, some experimental issues in the proposal for trappedion quantum computation by J. I. Cirac and P. Zoller (University of Innsbruck) are discussed. Several possible decoherence mechanisms are examined and what may be the more important of these are identified. Some potential applications for entangled states of trapped-ions which lie outside the immediate realm of quantum computation are also discussed. PMID:28009379

An experimental study of steam explosions involving chemically reactive metal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, D.H.; Armstrong, D.R.; Gunther, W.H.

1997-07-01

An experimental study of molten zirconium-water explosions was conducted. A 1-kg mass of zirconium melt was dropped into a column of water. Explosions took place only when an external trigger was used. In the triggered tests, the extent of oxidation of the zirconium melt was very extensive. However, the explosion energetics estimated were found to be very small compared to the potential chemical energy available from the oxidation reaction. Zirconium is of particular interest, since it is a component of the core materials of the current nuclear power reactors. This paper describes the test apparatus and summarizes the results ofmore » four tests conducted using pure zirconium melt.« less

Two-Phase Flow in Packed Columns and Generation of Bubbly Suspensions for Chemical Processing in Space

NASA Technical Reports Server (NTRS)

Motil, Brian J.; Green, R. D.; Nahra, H. K.; Sridhar, K. R.

2000-01-01

For long-duration space missions, the life support and In-Situ Resource Utilization (ISRU) systems necessary to lower the mass and volume of consumables carried from Earth will require more sophisticated chemical processing technologies involving gas-liquid two-phase flows. This paper discusses some preliminary two-phase flow work in packed columns and generation of bubbly suspensions, two types of flow systems that can exist in a number of chemical processing devices. The experimental hardware for a co-current flow, packed column operated in two ground-based low gravity facilities (two-second drop tower and KC- 135 low-gravity aircraft) is described. The preliminary results of this experimental work are discussed. The flow regimes observed and the conditions under which these flow regimes occur are compared with the available co-current packed column experimental work performed in normal gravity. For bubbly suspensions, the experimental hardware for generation of uniformly sized bubbles in Couette flow in microgravity conditions is described. Experimental work was performed on a number of bubbler designs, and the capillary bubble tube was found to produce the most consistent size bubbles. Low air flow rates and low Couette flow produce consistent 2-3 mm bubbles, the size of interest for the "Behavior of Rapidly Sheared Bubbly Suspension" flight experiment. Finally the mass transfer implications of these two-phase flows is qualitatively discussed.

Principles of Experimental Design for Big Data Analysis.

PubMed

Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

2017-08-01

Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis.

Principles of Experimental Design for Big Data Analysis

PubMed Central

Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

2016-01-01

Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis. PMID:28883686

High performance mode locking characteristics of single section quantum dash lasers.

PubMed

Rosales, Ricardo; Murdoch, S G; Watts, R T; Merghem, K; Martinez, Anthony; Lelarge, Francois; Accard, Alain; Barry, L P; Ramdane, Abderrahim

2012-04-09

Mode locking features of single section quantum dash based lasers are investigated. Particular interest is given to the static spectral phase profile determining the shape of the mode locked pulses. The phase profile dependence on cavity length and injection current is experimentally evaluated, demonstrating the possibility of efficiently using the wide spectral bandwidth exhibited by these quantum dash structures for the generation of high peak power sub-picosecond pulses with low radio frequency linewidths.

Current development of podophyllotoxins.

PubMed

Canetta, R; Hilgard, P; Florentine, S; Bedogni, P; Lenaz, L

1982-01-01

The unique biological properties and therapeutic efficacy of the podophyllotoxin derivatives, Vumon (VM26, teniposide) and Vepesid (VP16-213, etoposide), are stimulating the interest of both laboratory and clinical researchers. Investigations on new pharmaceutical formulations, pharmacokinetics and metabolism are providing more appropriate information in drug administration; experimental chemotherapy indicates that, among others, cytosine arabinoside and cisplatin are highly synergistic with podophyllotoxins; single agent and combination treatment clinical trials are defining the respective role of Vumon and Vepesid in cancer chemotherapy.

Theoretical Current-Voltage Curve in Low-Pressure Cesium Diode for Electron-Rich Emission

NASA Technical Reports Server (NTRS)

Coldstein, C. M.

1964-01-01

Although considerable interest has been shown in the space-charge analysis of low-pressure (collisionless case) thermionic diodes, there is a conspicuous lack in the presentation of results in a way that allows direct comparison with experiment. The current-voltage curve of this report was, therefore, computed for a typical case within the realm of experimental interest. The model employed in this computation is shown in Fig. 1 and is defined by the limiting potential distributions [curves (a) and (b)]. Curve (a) represents the potential V as a monotonic function of position with a slope of zero at the anode; curve (b) is similarly monotonic with a slope of zero at the cathode. It is assumed that by a continuous variation of the anode voltage, the potential distributions vary continuously from one limiting form to the other. Although solutions for infinitely spaced electrodes show that spatically oscillatory potential distributions may exist, they have been neglected in this computation.

On the role of cystatin C in cancer progression.

PubMed

Leto, Gaetano; Crescimanno, Marilena; Flandina, Carla

2018-06-01

Cystatin C (Cyst C) is an endogenous inhibitor of lysosomal cysteine proteinases, which has been shown to play a role in several normal and pathological processes. Interestingly, a growing number of experimental and clinical studies suggest that this inhibitor also appears to be implicated in the malignant progression of various human tumors. However, the role of Cyst C in malignant diseases is still controversial as these studies have highlighted that this protein may function either as tumor suppressor or tumor promoter. The specific mechanisms underlying these opposing effects at present remain murky and are the subject of many current investigations. On the other hand, a complete knowledge of these mechanisms is of clinical interest in order to develop new, effective antitumor treatments based on the appropriate use of natural and/or synthetic cysteine proteinase inhibitors. This paper discusses the current findings regarding the role of Cyst C in cancer progression and the clinical implications emerging from these studies. Copyright © 2018 Elsevier Inc. All rights reserved.

What Macromolecular Crowding Can Do to a Protein

PubMed Central

Kuznetsova, Irina M.; Turoverov, Konstantin K.; Uversky, Vladimir N.

2014-01-01

The intracellular environment represents an extremely crowded milieu, with a limited amount of free water and an almost complete lack of unoccupied space. Obviously, slightly salted aqueous solutions containing low concentrations of a biomolecule of interest are too simplistic to mimic the “real life” situation, where the biomolecule of interest scrambles and wades through the tightly packed crowd. In laboratory practice, such macromolecular crowding is typically mimicked by concentrated solutions of various polymers that serve as model “crowding agents”. Studies under these conditions revealed that macromolecular crowding might affect protein structure, folding, shape, conformational stability, binding of small molecules, enzymatic activity, protein-protein interactions, protein-nucleic acid interactions, and pathological aggregation. The goal of this review is to systematically analyze currently available experimental data on the variety of effects of macromolecular crowding on a protein molecule. The review covers more than 320 papers and therefore represents one of the most comprehensive compendia of the current knowledge in this exciting area. PMID:25514413

Electrochemical quantum tunneling for electronic detection and characterization of biological toxins

NASA Astrophysics Data System (ADS)

Gupta, Chaitanya; Walker, Ross M.; Gharpuray, Rishi; Shulaker, Max M.; Zhang, Zhiyong; Javanmard, Mehdi; Davis, Ronald W.; Murmann, Boris; Howe, Roger T.

2012-06-01

This paper introduces a label-free, electronic biomolecular sensing platform for the detection and characterization of trace amounts of biological toxins within a complex background matrix. The mechanism for signal transduction is the electrostatic coupling of molecule bond vibrations to charge transport across an insulated electrode-electrolyte interface. The current resulting from the interface charge flow has long been regarded as an experimental artifact of little interest in the development of traditional charge based biosensors like the ISFET, and has been referred to in the literature as a "leakage current". However, we demonstrate by experimental measurements and theoretical modeling that this current has a component that arises from the rate-limiting transition of a quantum mechanical electronic relaxation event, wherein the electronic tunneling process between a hydrated proton in the electrolyte and the metallic electrode is closely coupled to the bond vibrations of molecular species in the electrolyte. Different strategies to minimize the effect of quantum decoherence in the quantized exchange of energy between the molecular vibrations and electron energy will be discussed, as well as the experimental implications of such strategies. Since the mechanism for the transduction of chemical information is purely electronic and does not require labels or tags or optical transduction, the proposed platform is scalable. Furthermore, it can achieve the chemical specificity typically associated with traditional micro-array or mass spectrometry-based platforms that are used currently to analyze complex biological fluids for trace levels of toxins or pathogen markers.

Reynolds Stress Distributions and the Measurement and Calculation of Eddy Viscosity in Gravity Currents

NASA Astrophysics Data System (ADS)

Kelly, R. W.; Chalk, C.; Dorrell, R. M.; Peakall, J.; Burns, A. D.; Keevil, G. M.; Thomas, R. E.; Williams, G.

2016-12-01

In the natural environment, gravity currents transport large volumes of sediment great distances and are often considered one of the most important mechanisms for sediment transport in ocean basins. Deposits from many individual submarine gravity currents, turbidites, ultimately form submarine fan systems. These are the largest sedimentary systems on the planet and contain valuable hydrocarbon reserves. Moreover, the impact of these currents on submarine technologies and seafloor infrastructure can be devastating and therefore they are of significant interest to a wide range of industries. Here we present experimental, numerical and theoretical models of time-averaged turbulent shear stresses, i.e. Reynolds stresses. Reynolds stresses can be conceptually parameterised by an eddy viscosity parameter that relates chaotic fluid motion to diffusive type processes. As such, it is a useful parameter for indicating the extent of internal mixing and is used extensively in both numerical and analytical modelling of both open-channel and gravity driven flows. However, a lack of knowledge of the turbulent structure of gravity currents limits many hydro- and morphodynamic models. High resolution 3-dimensional experimental velocity data, gathered using acoustic Doppler profiling velocimetry, enabled direct calculation of stresses and eddy viscosity. Comparison of experimental data to CFD and analytical models allowed the testing of eddy viscosity-based turbulent mixing models. The calculated eddy viscosity profile is parabolic in nature in both the upper and lower shear layers. However, an apparent breakdown in the Boussinesq hypothesis (used to calculate the eddy viscosity and upon which many numerical models are based) is observed in the region of the current around the velocity maximum. With the use of accompanying density data it is suggested that the effect of stratification on eddy viscosity is significant and alternative formulations may be required.

Mapping Second Chromosome Mutations to Defined Genomic Regions in Drosophila melanogaster

PubMed Central

Kahsai, Lily; Cook, Kevin R.

2017-01-01

Hundreds of Drosophila melanogaster stocks are currently maintained at the Bloomington Drosophila Stock Center with mutations that have not been associated with sequence-defined genes. They have been preserved because they have interesting loss-of-function phenotypes. The experimental value of these mutations would be increased by tying them to specific genomic intervals so that geneticists can more easily associate them with annotated genes. Here, we report the mapping of 85 second chromosome complementation groups in the Bloomington collection to specific, small clusters of contiguous genes or individual genes in the sequenced genome. This information should prove valuable to Drosophila geneticists interested in processes associated with particular phenotypes and those searching for mutations affecting specific sequence-defined genes. PMID:29066472

GENIUS: web server to predict local gene networks and key genes for biological functions.

PubMed

Puelma, Tomas; Araus, Viviana; Canales, Javier; Vidal, Elena A; Cabello, Juan M; Soto, Alvaro; Gutiérrez, Rodrigo A

2017-03-01

GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accuracies comparable to highly discriminative Support Vector Machine methods. GENIUS currently supports eight model organisms and is freely available for public use at http://networks.bio.puc.cl/genius . genius.psbl@gmail.com. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Using a Non-Equivalent Groups Quasi Experimental Design to Reduce Internal Validity Threats to Claims Made by Math and Science K-12 Teacher Recruitment Programs

NASA Astrophysics Data System (ADS)

Moin, Laura

2009-10-01

The American Recovery and Reinvestment Act national policy established in 2009 calls for ``meaningful data'' that demonstrate educational improvements, including the recruitment of high-quality teachers. The scant data available and the low credibility of many K-12 math/science teacher recruitment program evaluations remain the major barriers for the identification of effective recruitment strategies. Our study presents a methodology to better evaluate the impact of recruitment programs on increasing participants' interest in teaching careers. The research capitalizes on the use of several control groups and presents a non-equivalent groups quasi-experimental evaluation design that produces program effect claims with higher internal validity than claims generated by current program evaluations. With this method that compares responses to a teaching career interest question from undergraduates all along a continuum from just attending an information session to participating (or not) in the recruitment program, we were able to compare the effect of the program in increasing participants' interest in teaching careers versus the evolution of the same interest but in the absence of the program. We were also able to make suggestions for program improvement and further research. While our findings may not apply to other K-12 math/science teacher recruitment programs, we believe that our evaluation methodology does and will contribute to conduct stronger program evaluations. In so doing, our evaluation procedure may inform recruitment program designers and policy makers.

Experimental evaluation of dual multiple aperture devices for fluence field modulated x-ray computed tomography

NASA Astrophysics Data System (ADS)

Mathews, A. J.; Gang, G.; Levinson, R.; Zbijewski, W.; Kawamoto, S.; Siewerdsen, J. H.; Stayman, J. W.

2017-03-01

Acquisition of CT images with comparable diagnostic power can potentially be achieved with lower radiation exposure than the current standard of care through the adoption of hardware-based fluence-field modulation (e.g. dynamic bowtie filters). While modern CT scanners employ elements such as static bowtie filters and tube-current modulation, such solutions are limited in the fluence patterns that they can achieve, and thus are limited in their ability to adapt to broad classes of patient morphology. Fluence-field modulation also enables new applications such as region-of-interest imaging, task specific imaging, reducing measurement noise or improving image quality. The work presented in this paper leverages a novel fluence modulation strategy that uses "Multiple Aperture Devices" (MADs) which are, in essence, binary filters, blocking or passing x-rays on a fine scale. Utilizing two MAD devices in series provides the capability of generating a large number of fluence patterns via small relative motions between the MAD filters. We present the first experimental evaluation of fluence-field modulation using a dual-MAD system, and demonstrate the efficacy of this technique with a characterization of achievable fluence patterns and an investigation of experimental projection data.

Filamentary structures in dense plasma focus: Current filaments or vortex filaments?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soto, Leopoldo, E-mail: lsoto@cchen.cl; Pavez, Cristian; Moreno, José

2014-07-15

Recent observations of an azimuthally distributed array of sub-millimeter size sources of fusion protons and correlation between extreme ultraviolet (XUV) images of filaments with neutron yield in PF-1000 plasma focus have re-kindled interest in their significance. These filaments have been described variously in literature as current filaments and vortex filaments, with very little experimental evidence in support of either nomenclature. This paper provides, for the first time, experimental observations of filaments on a table-top plasma focus device using three techniques: framing photography of visible self-luminosity from the plasma, schlieren photography, and interferometry. Quantitative evaluation of density profile of filaments frommore » interferometry reveals that their radius closely agrees with the collision-less ion skin depth. This is a signature of relaxed state of a Hall fluid, which has significant mass flow with equipartition between kinetic and magnetic energy, supporting the “vortex filament” description. This interpretation is consistent with empirical evidence of an efficient energy concentration mechanism inferred from nuclear reaction yields.« less

Modulating risky decision-making in Parkinson's disease by transcranial direct current stimulation.

PubMed

Benussi, A; Alberici, A; Cantoni, V; Manenti, R; Brambilla, M; Dell'Era, V; Gazzina, S; Manes, M; Cristillo, V; Padovani, A; Cotelli, M; Borroni, B

2017-05-01

Performance on gambling tasks in Parkinson's disease (PD) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (DLPFC) in modulating gambling behaviour in PD. We assessed the effects of cathodal tDCS over the right DLPFC during the Iowa Gambling Task in 20 patients with PD, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal tDCS over the right DLPFC. We observed that cathodal tDCS over the right DLPFC increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham tDCS. Cathodal tDCS over the right DLPFC possibly reduces the pathological overdrive in frontostriatal networks in patients with PD on dopaminergic medication, thus modulating impulsive and risky decision-making. © 2017 EAN.

Phenomenological Nusselt-Rayleigh Scaling of Turbulent Thermal Convection

NASA Astrophysics Data System (ADS)

Liu, Chien-Chia

2017-12-01

Natural convection between the hot floor and the cool ceiling, so called Rayleigh-Bénard convection, is pervasive and of both fundamental and industrial interests. One key issue is how heat transfer varies with increasing thermal potential, or equivalently how the Nusselt number (Nu) scales with the Rayleigh number (Ra). The overview of experimental findings remains to show the need of extra explanation complemental to the current theories. Here we present a model based on the phenomenological theory of turbulence, where the power-law spectral exponent of the energy spectrum is the only input parameter required. The goal aims to elucidate the unexplained aspect in the Nu-Ra scaling. We find that Kolmogorov turbulence in the current model leads to Nu ˜ Ra0.3, in good agreement with the modern experimental results. We hope that this model could stimulate the discussion as to the effects of the spectral phenomena on the Nu-Ra scaling, and thus augment our understanding of buoyancy-driven thermal convection.

Charged lepton mixing - an experimental overview

NASA Astrophysics Data System (ADS)

Rusu, Vadim

2015-04-01

Exploring the flavor sector of the Standard Model has always been a powerful probe in particle physics. Searches for charged leptons mixing, in particular muon decays, effectively pioneered this program almost 100 years ago. Still, even what one might consider, naively, simple questions, like why three lepton generations, are left unanswered. We do know now that neutral leptons (neutrinos) mix. We also know that, in all likelihood, the physics behind charged lepton mixing is also somehow responsible for generating neutrino masses. Not surprisingly, a revived interest in this field is currently under way, with experiments either ongoing or at planning stage throughout the world. The advent of powerful high intensity beams opens up new venues for exploration. Coupled with clever experimental ideas, sensitivities that were previously impossible to attain, are now within reach. I will review here the current status of charged lepton mixing experiments, what should we expect from the next generation projects and my view on how the field will progress in the future.

Plasma motor generator system

NASA Technical Reports Server (NTRS)

Hite, Gerald E.

1987-01-01

The significant potential advantages of a plasma motor generator system over conventional systems for the generation of electrical power and propulsion for spacecraft in low Earth orbits warrants its further investigation. The two main components of such a system are a long insulated wire and the plasma generating hollow cathodes needed to maintain electrical contact with the ionosphere. Results of preliminary theoretical and experimental investigations of this system are presented. The theoretical work involved the equilibrium configurations of the wire and the nature of small oscillation about these equilibrium positions. A particularly interesting result was that two different configurations are allowed when the current is above a critical value. Experimental investigations were made of the optimal starting and running conditions for the proposed, low current hollow cathodes. Although optimal ranges of temperature, argon pressure and discharge voltage were identified, start up became progressively more difficult. This supposed depletion or contamination of the emissive surface could be countered by the addition of new emissive material.

Priorities for Microgravity Combustion Research and Goals for Workshop Discussions

NASA Technical Reports Server (NTRS)

Faeth, Gerard M.

1993-01-01

Several concerns motivate fundamental research: combustion-generated pollutants are re-emerging as a major problem, new combustion technologies are needed for effective energy utilization, municipal and hazardous waste incineration are needed to replace landfills and storage, new combustion technologies are needed for advanced aircraft and spacecraft propulsion systems, and current understanding of fires and explosion hazards is limited - particularly for space-craft environments. Thus, it is of interest to determine how experimentation using microgravity facilities can advance research relevant to these problems.

Towards a dispersive determination of the pion transition form factor

NASA Astrophysics Data System (ADS)

Leupold, Stefan; Hoferichter, Martin; Kubis, Bastian; Niecknig, Franz; Schneider, Sebastian P.

2018-01-01

We start with a brief motivation why the pion transition form factor is interesting and, in particular, how it is related to the high-precision standard-model calculation of the gyromagnetic ratio of the muon. Then we report on the current status of our ongoing project to calculate the pion transition form factor using dispersion theory. Finally we present and discuss a wish list of experimental data that would help to improve the input for our calculations and/or to cross-check our results.

Transmission research activities at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Lewicki, D. G.

1990-01-01

A joint research program, to advance the technology of rotorcraft transmissions, consists of analytical and experimental efforts to achieve the overall goals of reducing transmission weight and noise, while increasing life and reliability. Recent activities in the areas of transmission and related component research are highlighted. Current areas include specific technologies in support of military rotary wing aviation, gearing technology, transmission noise reduction studies, a recent interest in gearbox diagnostics, and advanced transmission system studies. Results of recent activities are presented along with near term research plans.

Applying systems biology methods to the study of human physiology in extreme environments

PubMed Central

2013-01-01

Systems biology is defined in this review as ‘an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems’. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be used in experiments on healthy humans is extremely limited and principally comprises exercise, nutrition, infusions (e.g. Intralipid), some drugs and altered environment. Thus, we argue that systems biology and environmental physiology are natural symbionts for those interested in a system-level understanding of human biology. However, despite excellent progress in high-altitude genetics and several proteomics studies, systems biology research into human adaptation to extreme environments is in its infancy. A brief description and overview of systems biology in its current guise is given, followed by a mini review of computational methods used for modelling biological systems. Special attention is given to high-altitude research, metabolic network reconstruction and constraint-based modelling. PMID:23849719

Experimental Evaluation of Grid Support Enabled PV Inverter Response to Abnormal Grid Conditions: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Austin; Martin, Gregory; Hurtt, James

As revised interconnection standards for grid-tied photovoltaic (PV) inverters address new advanced grid support functions (GSFs), there is increasing interest in inverter performance in the case of abnormal grid conditions. The growth of GSF-enabled inverters has outpaced the industry standards that define their operation, although recently published updates to UL1741 with Supplement SA define test conditions for GSFs such as volt-var control, frequency-watt control, and volt-age/frequency ride-through, among others. A comparative experimental evaluation has been completed on four commercially available, three-phase PV inverters in the 24.0-39.8 kVA power range on their GSF capability and the effect on abnormal grid conditionmore » response. This study examines the impact particular GSF implementations have on run-on times during islanding conditions, peak voltages in load rejection overvoltage scenarios, and peak currents during single-phase and three-phase fault events for individual inverters. This report reviews comparative test data, which shows that GSFs have little impact on the metrics of interest in most tests cases.« less

Experimental investigation of homogeneous charge compression ignition combustion of biodiesel fuel with external mixture formation in a CI engine.

PubMed

Ganesh, D; Nagarajan, G; Ganesan, S

2014-01-01

In parallel to the interest in renewable fuels, there has also been increased interest in homogeneous charge compression ignition (HCCI) combustion. HCCI engines are being actively developed because they have the potential to be highly efficient and to produce low emissions. Even though HCCI has been researched extensively, few challenges still exist. These include controlling the combustion at higher loads and the formation of a homogeneous mixture. To obtain better homogeneity, in the present investigation external mixture formation method was adopted, in which the fuel vaporiser was used to achieve excellent HCCI combustion in a single cylinder air-cooled direct injection diesel engine. In continuation of our previous works, in the current study a vaporised jatropha methyl ester (JME) was mixed with air to form a homogeneous mixture and inducted into the cylinder during the intake stroke to analyze the combustion, emission and performance characteristics. To control the early ignition of JME vapor-air mixture, cooled (30 °C) Exhaust gas recirculation (EGR) technique was adopted. The experimental result shows 81% reduction in NOx and 72% reduction in smoke emission.

Experimental and numerical simulation of three-dimensional gravity currents on smooth and rough bottom

NASA Astrophysics Data System (ADS)

La Rocca, Michele; Adduce, Claudia; Sciortino, Giampiero; Pinzon, Allen Bateman

2008-10-01

The dynamics of a three-dimensional gravity current is investigated by both laboratory experiments and numerical simulations. The experiments take place in a rectangular tank, which is divided into two square reservoirs with a wall containing a sliding gate of width b. The two reservoirs are filled to the same height H, one with salt water and the other with fresh water. The gravity current starts its evolution as soon as the sliding gate is manually opened. Experiments are conducted with either smooth or rough surface on the bottom of the tank. The bottom roughness is created by gluing sediment material of different diameters to the surface. Five diameter values for the surface roughness and two salinity conditions for the fluid are investigated. The mathematical model is based on shallow-water theory together with the single-layer approximation, so that the model is strictly hyperbolic and can be put into conservative form. Consequently, a finite-volume-based numerical algorithm can be applied. The Godunov formulation is used together with Roe's approximate Riemann solver. Comparisons between the numerical and experimental results show satisfactory agreement. The behavior of the gravity current is quite unusual and cannot be interpreted using the usual model framework adopted for two-dimensional and axisymmetric gravity currents. Two main phases are apparent in the gravity current evolution; during the first phase the front velocity increases, and during the second phase the front velocity decreases and the dimensionless results, relative to the different densities, collapse onto the same curve. A systematic discrepancy is seen between the numerical and experimental results, mainly during the first phase of the gravity current evolution. This discrepancy is attributed to the limits of the mathematical formulation, in particular, the neglect of entrainment in the mathematical model. An interesting result arises from the influence of the bottom surface roughness; it both reduces the front velocity during the second phase of motion and attenuates the differences between the experimental and numerical front velocities during the first phase of motion.

Current perspectives on the biological study of play: signs of progress.

PubMed

Graham, Kerrie Lewis; Burghardt, Gordon M

2010-12-01

There has been a recent resurgence of interest in the study of play behavior, marked by much empirical research and theoretical review. These efforts suggest that play may be of greater biological significance than most scientists realize. Here we present a brief synopsis of current play research covering issues of adaptive function, phylogeny, causal mechanisms, and development. Our goal is to selectively highlight contemporary areas of research in which the underlying processes and consequences of play should not be ignored. We elucidate some of the new and burgeoning areas of play research and interpret them from an integrative biological theoretical perspective that highlights areas in need of further experimental, comparative, and field research.

Perspectives on biotechnological applications of archaea

PubMed Central

Schiraldi, Chiara; Giuliano, Mariateresa; De Rosa, Mario

2002-01-01

Many archaea colonize extreme environments. They include hyperthermophiles, sulfur-metabolizing thermophiles, extreme halophiles and methanogens. Because extremophilic microorganisms have unusual properties, they are a potentially valuable resource in the development of novel biotechnological processes. Despite extensive research, however, there are few existing industrial applications of either archaeal biomass or archaeal enzymes. This review summarizes current knowledge about the biotechnological uses of archaea and archaeal enzymes with special attention to potential applications that are the subject of current experimental evaluation. Topics covered include cultivation methods, recent achievements in genomics, which are of key importance for the development of new biotechnological tools, and the application of wild-type biomasses, engineered microorganisms, enzymes and specific metabolites in particular bioprocesses of industrial interest. PMID:15803645

Perspectives on biotechnological applications of archaea.

PubMed

Schiraldi, Chiara; Giuliano, Mariateresa; De Rosa, Mario

2002-09-01

Many archaea colonize extreme environments. They include hyperthermophiles, sulfur-metabolizing thermophiles, extreme halophiles and methanogens. Because extremophilic microorganisms have unusual properties, they are a potentially valuable resource in the development of novel biotechnological processes. Despite extensive research, however, there are few existing industrial applications of either archaeal biomass or archaeal enzymes. This review summarizes current knowledge about the biotechnological uses of archaea and archaeal enzymes with special attention to potential applications that are the subject of current experimental evaluation. Topics covered include cultivation methods, recent achievements in genomics, which are of key importance for the development of new biotechnological tools, and the application of wild-type biomasses, engineered microorganisms, enzymes and specific metabolites in particular bioprocesses of industrial interest.

Measurement and Characterization of Concentrator Solar Cells II

NASA Technical Reports Server (NTRS)

Scheiman, Dave; Sater, Bernard L.; Chubb, Donald; Jenkins, Phillip; Snyder, Dave

2005-01-01

Concentrator solar cells are continuing to get more consideration for use in power systems. This interest is because concentrator systems can have a net lower cost per watt in solar cell materials plus ongoing improvements in sun-tracking technology. Quantitatively measuring the efficiency of solar cells under concentration is difficult. Traditionally, the light concentration on solar cells has been determined by using a ratio of the measured solar cell s short circuit current to that at one sun, this assumes that current changes proportionally with light intensity. This works well with low to moderate (<20 suns) concentration levels on "well-behaved" linear cells but does not apply when cells respond superlinearly, current increases faster than intensity, or sublinearly, current increases more slowly than intensity. This paper continues work on using view factors to determine the concentration level and linearity of the solar cell with mathematical view factor analysis and experimental results [1].

Can Direct Current Electrotherapy Be Used for Patients With Orthopedic Implants?

PubMed Central

Thaler, Evangeline; Korte, Holger

2017-01-01

Introduction: Although electrotherapy appears to have particularly interesting applications in the field of postoperative orthopedic rehabilitation, relatively little scientifically based research has been conducted in the area of electrotherapy with regard to safety involving patients with orthopedic implants. Method: Three electrotherapy forms were tested, such as high-volt stimulation (HVS), transcutaneous electric nerve stimulation (TENS), and galvanic current (GAL), using a model system containing a metal implant plate to evaluate whether heating in excess of 3°C would occur. Results: All changes in temperature for HVS, GAL, and TENS therapeutic electrical currents observed in our model system fall below the predefined 3°C. Conclusion: To the best of our knowledge, this is the first experimental based observation that prolonged exposure to a direct electrical current at therapeutic strength does not result in heating of metal titanium plates. PMID:28255511

Tilt Grain Boundary Topology Induced by Substrate Topography.

PubMed

Yu, Henry; Gupta, Nitant; Hu, Zhili; Wang, Kai; Srijanto, Bernadeta R; Xiao, Kai; Geohegan, David B; Yakobson, Boris I

2017-09-26

Synthesis of two-dimensional (2D) crystals is a topic of great current interest, since their chemical makeup, electronic, mechanical, catalytic, and optical properties are so diverse. A universal challenge, however, is the generally random formation of defects caused by various growth factors on flat surfaces. Here we show through theoretical analysis and experimental demonstration that nonplanar, curved-topography substrates permit the intentional and controllable creation of topological defects within 2D materials. We augment a common phase-field method by adding a geometric phase to track the crystal misorientation on a curved surface and to detect the formation of grain boundaries, especially when a growing monocrystal "catches its own tail" on a nontrivial topographical feature. It is specifically illustrated by simulated growth of a trigonal symmetry crystal on a conical-planar substrate, to match the experimental synthesis of WS 2 on silicon template, with satisfactory and in some cases remarkable agreement of theory predictions and experimental evidence.

Experimental Potential Energy Curve for the 43 Π Electronic State of NaCs

NASA Astrophysics Data System (ADS)

Steely, Andrew; Cooper, Hannah; Zain, Hareem; Whipp, Ciara; Faust, Carl; Kortyna, Andrew; Huennekens, John

2017-04-01

We present results from experimental studies of the 43 Π electronic state of the NaCs molecule. This electronic state is interesting in that its potential energy curve likely exhibits a double minimum. As a result, interference effects are observed in the resolved bound-free fluorescence spectra. The optical-optical double resonance method was used to obtain Doppler-free excitation spectra for the 43 Π state. This dataset of measured level energies was expanded largely by observing fluorescence from levels populated by collisions. To aid in level assignments, simulations of resolved bound-free fluorescence spectra were calculated using the BCONT program (R. J. Le Roy, University of Waterloo). Spectroscopic constants were determined to summarize data belonging to inner well, outer well, and above barrier regions of the electronic state. Current work focuses on using the IPA method to construct an experimental potential energy curve. Work supported by NSF and Susquehanna University.

Micromachined probes for laboratory plasmas

NASA Astrophysics Data System (ADS)

Chiang, Franklin Changta

As we begin to find more applications for plasmas in our everyday lives, the ability to characterize and understand their inner workings becomes increasingly important. Much of our current understanding of plasma physics comes from investigations conducted in diffuse, outer space plasmas where experimenters have no control over the environment or experimental conditions and one measures interesting phenomena only by chance when the spacecraft or satellite passes through them. Ideally, experiments should be performed in a controlled environment, where plasma events can be deliberately and reliably created when wanted and probes placed precisely within the plasma. Unfortunately, often due to their size, probes used in outer space are unsuitable for use in high-density laboratory plasmas, and constructing probes that can be used in terrestrial plasmas is a considerable challenge. This dissertation presents the development, implementation, and experimental results of three micromachined probes capable of measuring voltage and electric field, ion energies, and changing magnetic fields (B-dot) in laboratory plasmas.

Experimental medical mycological research in Latin America - a 2000-2009 overview.

PubMed

San-Blas, Gioconda; Burger, Eva

2011-01-01

An overview of current trends in Latin American Experimental Medical Mycological research since the beginning of the 21(st) century is done (search from January 2000 to December 2009). Using the PubMed and LILACS databases, the authors have chosen publications on medically important fungi which, according to our opinion, are the most relevant because of their novelty, interest, and international impact, based on research made entirely in the Latin American region or as part of collaborative efforts with laboratories elsewhere. In this way, the following areas are discussed: 1) molecular identification of fungal pathogens; 2) molecular and clinical epidemiology on fungal pathogens of prevalence in the region; 3) cell biology; 4) transcriptome, genome, molecular taxonomy and phylogeny; 5) immunology; 6) vaccines; 7) new and experimental antifungals. Copyright © 2010 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Proteomics data repositories

PubMed Central

Riffle, Michael; Eng, Jimmy K.

2010-01-01

The field of proteomics, particularly the application of mass spectrometry analysis to protein samples, is well-established and growing rapidly. Proteomics studies generate large volumes of raw experimental data and inferred biological results. To facilitate the dissemination of these data, centralized data repositories have been developed that make the data and results accessible to proteomics researchers and biologists alike. This review of proteomics data repositories focuses exclusively on freely-available, centralized data resources that disseminate or store experimental mass spectrometry data and results. The resources chosen reflect a current “snapshot” of the state of resources available with an emphasis placed on resources that may be of particular interest to yeast researchers. Resources are described in terms of their intended purpose and the features and functionality provided to users. PMID:19795424

Exploring the dynamics of collective cognition using a computational model of cognitive dissonance

NASA Astrophysics Data System (ADS)

Smart, Paul R.; Sycara, Katia; Richardson, Darren P.

2013-05-01

The socially-distributed nature of cognitive processing in a variety of organizational settings means that there is increasing scientific interest in the factors that affect collective cognition. In military coalitions, for example, there is a need to understand how factors such as communication network topology, trust, cultural differences and the potential for miscommunication affects the ability of distributed teams to generate high quality plans, to formulate effective decisions and to develop shared situation awareness. The current paper presents a computational model and associated simulation capability for performing in silico experimental analyses of collective sensemaking. This model can be used in combination with the results of human experimental studies in order to improve our understanding of the factors that influence collective sensemaking processes.

Rapidity dependence in holographic heavy ion collisions

DOE PAGES

Wilke van der Schee; Schenke, Bjorn

2015-12-11

We present an attempt to closely mimic the initial stage of heavy ion collisions within holography, assuming a decoupling of longitudinal and transverse dynamics in the very early stage. We subsequently evolve the obtained initial state using state-of-the-art hydrodynamic simulations and compare results with experimental data. We present results for charged hadron pseudorapidity spectra and directed and elliptic flow as functions of pseudorapidity for √s NN = 200GeV Au-Au and 2.76TeV Pb-Pb collisions. As a result, the directed flow interestingly turns out to be quite sensitive to the viscosity. The results can explain qualitative features of the collisions, but themore » rapidity spectra in our current model is narrower than the experimental data.« less

Theoretical research program to study transition metal trimers and embedded clusters

NASA Technical Reports Server (NTRS)

Walch, S. P.

1984-01-01

Small transition metal clusters were studied at a high level of approximation, including all the valence electrons in the calculation and extensive electron correlation, in order to understand the electronic structure of these small metal clusters. By comparison of dimers, trimers, and possibly higher clusters, the information obtained was used to provide insights into the electronic structure of bulk transition metals. Small metal clusters are currently of considerable experimental interest and some information is becomming available both from matrix electron spin resonance studies and from gas phase spectroscopy. Collaboration between theorists and experimentalists is thus expected to be especially profitable at this time since there is some experimental information which can serve to guide the theoretical work.

Exploring the Effects of Atmospheric Forcings on Evaporation: Experimental Integration of the Atmospheric Boundary Layer and Shallow Subsurface

PubMed Central

Smits, Kathleen; Eagen, Victoria; Trautz, Andrew

2015-01-01

Evaporation is directly influenced by the interactions between the atmosphere, land surface and soil subsurface. This work aims to experimentally study evaporation under various surface boundary conditions to improve our current understanding and characterization of this multiphase phenomenon as well as to validate numerical heat and mass transfer theories that couple Navier-Stokes flow in the atmosphere and Darcian flow in the porous media. Experimental data were collected using a unique soil tank apparatus interfaced with a small climate controlled wind tunnel. The experimental apparatus was instrumented with a suite of state of the art sensor technologies for the continuous and autonomous collection of soil moisture, soil thermal properties, soil and air temperature, relative humidity, and wind speed. This experimental apparatus can be used to generate data under well controlled boundary conditions, allowing for better control and gathering of accurate data at scales of interest not feasible in the field. Induced airflow at several distinct wind speeds over the soil surface resulted in unique behavior of heat and mass transfer during the different evaporative stages. PMID:26131928

Spatially resolved, in-situ monitoring of crack growth via the coupling current in aluminum alloy 5083

NASA Astrophysics Data System (ADS)

Williams, Krystaufeux D.

The work discussed in this dissertation is an experimental validation of a body of research that was created to model stress corrosion cracking phenomenon for 304 stainless steels in boiling water reactors. This coupled environment fracture model (CEFM) incorporates the natural laws of the conservation of charge and the differential aeration hypothesis to predict the amount of stress corrosion crack growth as a function of many external environmental variables, including potential, stress intensity, solution conductivity, oxidizer concentrations, and various other environmental parameters. Out of this approach came the concept of the coupling current; a local corrosion current that flows from within cracks, crevices, pits, etc... of a metal or alloy to the external surface. Because of the deterministic approach taken in the mentioned research, the coupling current analysis and CEFM model can be applied to the specific problem of SCC in aluminum alloy 5083 (the alloy of interest for this dissertation that is highly sought after today because of its corrosion resistance and high strength to weight ratio). This dissertation research is specifically devoted to the experimental verification of the coupling current, which results from a coupling between the crack's internal and external environments, by spatially resolving them using the scanning vibrating probe (SVP) as a tool. Hence, through the use of a unique fracture mechanics setup, simultaneous mechanical and local electrochemical data may be obtained, in situ..

Viral infections and breast cancer - A current perspective.

PubMed

Gannon, O M; Antonsson, A; Bennett, I C; Saunders, N A

2018-04-28

Sporadic human breast cancer is the most common cancer to afflict women. Since the discovery, decades ago, of the oncogenic mouse mammary tumour virus, there has been significant interest in the potential aetiologic role of infectious agents in sporadic human breast cancer. To address this, many studies have examined the presence of viruses (e.g. papillomaviruses, herpes viruses and retroviruses), endogenous retroviruses and more recently, microbes, as a means of implicating them in the aetiology of human breast cancer. Such studies have generated conflicting experimental and clinical reports of the role of infection in breast cancer. This review evaluates the current evidence for a productive oncogenic viral infection in human breast cancer, with a focus on the integration of sensitive and specific next generation sequencing technologies with pathogen discovery. Collectively, the majority of the recent literature using the more powerful next generation sequencing technologies fail to support an oncogenic viral infection being involved in disease causality in breast cancer. In balance, the weight of the current experimental evidence supports the conclusion that viral infection is unlikely to play a significant role in the aetiology of breast cancer. Copyright © 2018 Elsevier B.V. All rights reserved.

Mission Systems Open Architecture Science and Technology (MOAST) program

NASA Astrophysics Data System (ADS)

Littlejohn, Kenneth; Rajabian-Schwart, Vahid; Kovach, Nicholas; Satterthwaite, Charles P.

2017-04-01

The Mission Systems Open Architecture Science and Technology (MOAST) program is an AFRL effort that is developing and demonstrating Open System Architecture (OSA) component prototypes, along with methods and tools, to strategically evolve current OSA standards and technical approaches, promote affordable capability evolution, reduce integration risk, and address emerging challenges [1]. Within the context of open architectures, the program is conducting advanced research and concept development in the following areas: (1) Evolution of standards; (2) Cyber-Resiliency; (3) Emerging Concepts and Technologies; (4) Risk Reduction Studies and Experimentation; and (5) Advanced Technology Demonstrations. Current research includes the development of methods, tools, and techniques to characterize the performance of OMS data interconnection methods for representative mission system applications. Of particular interest are the OMS Critical Abstraction Layer (CAL), the Avionics Service Bus (ASB), and the Bulk Data Transfer interconnects, as well as to develop and demonstrate cybersecurity countermeasures techniques to detect and mitigate cyberattacks against open architecture based mission systems and ensure continued mission operations. Focus is on cybersecurity techniques that augment traditional cybersecurity controls and those currently defined within the Open Mission System and UCI standards. AFRL is also developing code generation tools and simulation tools to support evaluation and experimentation of OSA-compliant implementations.

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

PubMed Central

Willebrords, Joost; Pereira, Isabel Veloso Alves; Maes, Michaël; Yanguas, Sara Crespo; Colle, Isabelle; Van Den Bossche, Bert; Da silva, Tereza Cristina; Oliveira, Cláudia P; Andraus, Wellington; Alves, Venâncio Avancini Ferreira; Cogliati, Bruno; Vinken, Mathieu

2015-01-01

Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma. Non-alcoholic fatty liver disease is currently the most dominant chronic liver disease in Western countries due to the fact that hepatic steatosis is associated with insulin resistance, type 2 diabetes mellitus, obesity, metabolic syndrome and drug-induced injury. A variety of chemicals, mainly drugs, and diets is known to cause hepatic steatosis in humans and rodents. Experimental non-alcoholic fatty liver disease models rely on the application of a diet or the administration of drugs to laboratory animals or the exposure of hepatic cell lines to these drugs. More recently, genetically modified rodents or zebrafish have been introduced as non-alcoholic fatty liver disease models. Considerable interest now lies in the discovery and development of novel non-invasive biomarkers of non-alcoholic fatty liver disease, with specific focus on hepatic steatosis. Experimental diagnostic biomarkers of non-alcoholic fatty liver disease, such as (epi)genetic parameters and ‘-omics’-based read-outs are still in their infancy, but show great promise. . In this paper, the array of tools and models for the study of liver steatosis is discussed. Furthermore, the current state-of-art regarding experimental biomarkers such as epigenetic, genetic, transcriptomic, proteomic and metabonomic biomarkers will be reviewed. PMID:26073454

Lattice Gauge Theories Within and Beyond the Standard Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gelzer, Zechariah John

The Standard Model of particle physics has been very successful in describing fundamental interactions up to the highest energies currently probed in particle accelerator experiments. However, the Standard Model is incomplete and currently exhibits tension with experimental data for interactions involvingmore » $B$~mesons. Consequently, $B$-meson physics is of great interest to both experimentalists and theorists. Experimentalists worldwide are studying the decay and mixing processes of $B$~mesons in particle accelerators. Theorists are working to understand the data by employing lattice gauge theories within and beyond the Standard Model. This work addresses the theoretical effort and is divided into two main parts. In the first part, I present a lattice-QCD calculation of form factors for exclusive semileptonic decays of $B$~mesons that are mediated by both charged currents ($$B \\to \\pi \\ell \

Investigation of the Static and Dynamic Characteristics for a Wafer-Fused C-band VCSEL in the Mode of the Optical-Electric Converter

NASA Astrophysics Data System (ADS)

Belkin, M. E.

2018-01-01

The results of an experimental study for a long wavelength vertical cavity surface-emitting laser of a wafer-fused construction as an effective resonant cavity enhanced photodetector of analog optical signals are described. The device is of interest for a number of promising microwave photonics applications and for creation of a low-cost photoreceiver in a high-speed fiber optics telecommunication system with dense wavelength division multiplexing. The schematic of the testbed, the original technique allowing to calculate the passband of the built-in optical cavity, and the results of measuring dark current, current responsivity, amplitude- and phase-frequency characteristics during the process of photo-detection are demonstrated.

Modeling and Compensation of the Internal Friction Torque of a Travelling Wave Ultrasonic Motor.

PubMed

Giraud, F; Sandulescu, P; Amberg, M; Lemaire-Semail, B; Ionescu, F

2011-01-01

This paper deals with the control and experimentation of a one-degree-of-freedom haptic stick, actuated by a travelling wave ultrasonic motor. This type of actuator has many interesting properties such as low-speed operation capabilities and a high torque-to-weight ratio, making it appropriate for haptic applications. However, the motor used in this application displays nonlinear behavior due to the necessary contact between its rotor and stator. Moreover, due to its energy conversion process, the torque applied to the end-effector is not a straightforward function of the supply current or voltage. This is why a force-feedback control strategy is presented, which includes an online parameter estimator. Experimental runs are then presented to examine the fidelity of the interface.

Cumulative reports and publications

NASA Technical Reports Server (NTRS)

1993-01-01

A complete list of Institute for Computer Applications in Science and Engineering (ICASE) reports are listed. Since ICASE reports are intended to be preprints of articles that will appear in journals or conference proceedings, the published reference is included when it is available. The major categories of the current ICASE research program are: applied and numerical mathematics, including numerical analysis and algorithm development; theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustics and combustion; experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and computer science.

Magnetohydrodynamic modelling of exploding foil initiators

NASA Astrophysics Data System (ADS)

Neal, William

2015-06-01

Magnetohydrodynamic (MHD) codes are currently being developed, and used, to predict the behaviour of electrically-driven flyer-plates. These codes are of particular interest to the design of exploding foil initiator (EFI) detonators but there is a distinct lack of comparison with high-fidelity experimental data. This study aims to compare a MHD code with a collection of temporally and spatially resolved diagnostics including PDV, dual-axis imaging and streak imaging. The results show the code's excellent representation of the flyer-plate launch and highlight features within the experiment that the model fails to capture.

Characterization of Stereo Vision Performance for Roving at the Lunar Poles

NASA Technical Reports Server (NTRS)

Wong, Uland; Nefian, Ara; Edwards, Larry; Furlong, Michael; Bouyssounouse, Xavier; To, Vinh; Deans, Matthew; Cannon, Howard; Fong, Terry

2016-01-01

Surface rover operations at the polar regions of airless bodies, particularly the Moon, are of particular interest to future NASA science missions such as Resource Prospector (RP). Polar optical conditions present challenges to conventional imaging techniques, with repercussions to driving, safeguarding and science. High dynamic range, long cast shadows, opposition and white out conditions are all significant factors in appearance. RP is currently undertaking an effort to characterize stereo vision performance in polar conditions through physical laboratory experimentation with regolith simulants, obstacle distributions and oblique lighting.

A study of hadronic decays of the chi(c) states produced in psi-prime radiative transitions at the Beijing Experimental Spectrometer

NASA Astrophysics Data System (ADS)

Varner, Gary Sim

1999-11-01

Utilizing the world's largest sample of resonant y' decays, as measured by the Beijing Experimental Spectrometer (BES) during 1993-1995, a comprehensive study of the hadronic decay modes of the χc (3P1 Charmonium) states has been undertaken. Compared with the data set for the Mark I detector, whose published measurements of many of these hadronic decays have been definitive for almost 20 years, roughly an order of magnitude larger statistics has been obtained. Taking advantage of these larger statistics, many new hadronic decay modes have been discovered, while others have been refined. An array of first observations, improvements, confirmations or limits are reported with respect to current world values. These higher precision and newly discovered decay modes are an excellent testing ground for recent theoretical interest in the contribution of higher Fock states and the color octet mechanism in heavy quarkonium annihilation and subsequent light hadronization. Because these calculations are largely tractable only in two body decays, these are the focus of this dissertation. A comparison of current theoretical calculations and experimental results is presented, indicating the success of these phenomenological advances. Measurements for which there are as yet no suitable theoretical prediction are indicated.

Feasibility study for a biomedical experimental facility based on LEIR at CERN.

PubMed

Abler, Daniel; Garonna, Adriano; Carli, Christian; Dosanjh, Manjit; Peach, Ken

2013-07-01

In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive research into the radiobiological mechanisms of ion beam radiation and the development of more refined techniques of dosimetry and imaging. This basic research would support the current clinical efforts of the new treatment centres in Europe (for example HIT, CNAO and MedAustron). This paper presents first investigations on the feasibility of an experimental biomedical facility based on the CERN Low Energy Ion Ring LEIR accelerator. Such a new facility could provide beams of light ions (from protons to neon ions) in a collaborative and cost-effective way, since it would rely partly on CERN's competences and infrastructure. The main technical challenges linked to the implementation of a slow extraction scheme for LEIR and to the design of the experimental beamlines are described and first solutions presented. These include introducing new extraction septa into one of the straight sections of the synchrotron, changing the power supply configuration of the magnets, and designing a new horizontal beamline suitable for clinical beam energies, and a low-energy vertical beamline for particular radiobiological experiments.

Feasibility study for a biomedical experimental facility based on LEIR at CERN

PubMed Central

Abler, Daniel; Garonna, Adriano; Carli, Christian; Dosanjh, Manjit; Peach, Ken

2013-01-01

In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive research into the radiobiological mechanisms of ion beam radiation and the development of more refined techniques of dosimetry and imaging. This basic research would support the current clinical efforts of the new treatment centres in Europe (for example HIT, CNAO and MedAustron). This paper presents first investigations on the feasibility of an experimental biomedical facility based on the CERN Low Energy Ion Ring LEIR accelerator. Such a new facility could provide beams of light ions (from protons to neon ions) in a collaborative and cost-effective way, since it would rely partly on CERN's competences and infrastructure. The main technical challenges linked to the implementation of a slow extraction scheme for LEIR and to the design of the experimental beamlines are described and first solutions presented. These include introducing new extraction septa into one of the straight sections of the synchrotron, changing the power supply configuration of the magnets, and designing a new horizontal beamline suitable for clinical beam energies, and a low-energy vertical beamline for particular radiobiological experiments. PMID:23824122

Teaching neurophysiology, neuropharmacology, and experimental design using animal models of psychiatric and neurological disorders.

PubMed

Morsink, Maarten C; Dukers, Danny F

2009-03-01

Animal models have been widely used for studying the physiology and pharmacology of psychiatric and neurological diseases. The concepts of face, construct, and predictive validity are used as indicators to estimate the extent to which the animal model mimics the disease. Currently, we used these three concepts to design a theoretical assignment to integrate the teaching of neurophysiology, neuropharmacology, and experimental design. For this purpose, seven case studies were developed in which animal models for several psychiatric and neurological diseases were described and in which neuroactive drugs used to treat or study these diseases were introduced. Groups of undergraduate students were assigned to one of these case studies and asked to give a classroom presentation in which 1) the disease and underlying pathophysiology are described, 2) face and construct validity of the animal model are discussed, and 3) a pharmacological experiment with the associated neuroactive drug to assess predictive validity is presented. After evaluation of the presentations, we found that the students had gained considerable insight into disease phenomenology, its underlying neurophysiology, and the mechanism of action of the neuroactive drug. Moreover, the assignment was very useful in the teaching of experimental design, allowing an in-depth discussion of experimental control groups and the prediction of outcomes in these groups if the animal model were to display predictive validity. Finally, the highly positive responses in the student evaluation forms indicated that the assignment was of great interest to the students. Hence, the currently developed case studies constitute a very useful tool for teaching neurophysiology, neuropharmacology, and experimental design.

Experimental demonstration of conflicting interest nonlocal games using superconducting qubits

NASA Astrophysics Data System (ADS)

Situ, Haozhen; Li, Lvzhou; Huang, Zhiming; He, Zhimin; Zhang, Cai

2018-06-01

Conflicting interest nonlocal games are special Bayesian games played by noncooperative players without communication. In recent years, some conflicting interest nonlocal games have been proposed where quantum advice can help players to obtain higher payoffs. In this work we perform an experiment of six conflicting interest nonlocal games using the IBM quantum computer made up of five superconducting qubits. The experimental results demonstrate quantum advantage in four of these games, whereas the other two games fail to showcase quantum advantage in the experiment.

Flexible manipulator control experiments and analysis

NASA Technical Reports Server (NTRS)

Yurkovich, S.; Ozguner, U.; Tzes, A.; Kotnik, P. T.

1987-01-01

Modeling and control design for flexible manipulators, both from an experimental and analytical viewpoint, are described. From the application perspective, an ongoing effort within the laboratory environment at the Ohio State University, where experimentation on a single link flexible arm is underway is described. Several unique features of this study are described here. First, the manipulator arm is slewed by a direct drive dc motor and has a rigid counterbalance appendage. Current experimentation is from two viewpoints: (1) rigid body slewing and vibration control via actuation with the hub motor, and (2) vibration suppression through the use of structure-mounted proof-mass actuation at the tip. Such an application to manipulator control is of interest particularly in design of space-based telerobotic control systems, but has received little attention to date. From an analytical viewpoint, parameter estimation techniques within the closed-loop for self-tuning adaptive control approaches are discussed. Also introduced is a control approach based on output feedback and frequency weighting to counteract effects of spillover in reduced-order model design. A model of the flexible manipulator based on experimental measurements is evaluated for such estimation and control approaches.

Use Of Zernike Polynomials And Interferometry In The Optical Design And Assembly Of Large Carbon-Dioxide Laser Systems

NASA Astrophysics Data System (ADS)

Viswanathan, V. K.

1982-02-01

This paper describes the need for non-raytracing schemes in the optical design and analysis of large carbon-dioxide lasers like the Gigawatt,1 Gemini, 2 and Helios3 lasers currently operational at Los Alamos, and the Antares 4 laser fusion system under construction. The scheme currently used at Los Alamos involves characterizing the various optical components with a Zernike polynomial sets obtained by the digitization6 of experimentally produced interferograms of the components. A Fast Fourier Transform code then propagates the complex amplitude and phase of the beam through the whole system and computes the optical parameters of interest. The analysis scheme is illustrated through examples of the Gigawatt, Gemini, and Helios systems. A possible way of using the Zernike polynomials in optical design problems of this type is discussed. Comparisons between the computed values and experimentally obtained results are made and it is concluded that this appears to be a valid approach. As this is a review article, some previously published results are also used where relevant.

High Tc SQUIDs and eddy-current NDE: a comprehensive investigation from real data to modelling

NASA Astrophysics Data System (ADS)

Ruosi, A.; Valentino, M.; Pepe, G.; Monebhurrun, V.; Lesselier, D.; Duchêne, B.

2000-11-01

The interest in magnetometry for eddy-current non-destructive testing, e.g. of planar conductive structures encountered in the aircraft industry, using high-temperature superconducting quantum interference devices (SQUIDs) is primarily due to their high sensitivity to magnetic flux even at very low frequencies. Here it is shown how theoretical, numerical and measurement machineries are combined to get reasonable synthetic and experimental data and to reach a good understanding of the interaction of diffusive wavefields with a damaged non-magnetic metal plate (as a first step towards the retrieval of pertinent features of the defects). The measurement modalities are considered first. It is illustrated in some detail how laboratory-controlled experiments are performed by a SQUID-based probe displaced above artificially damaged plates. Experimental data are then confronted with simulation results in order to evaluate the accuracy and reliability of this measurement system. Simulations are carried out by a computationally fast vector volume integral method dedicated to a planar layering affected by a volumetric defect, which involves the construction of the dyadic Green system of the layering.

The use of precious-metal-modified nickel-based superalloys for thin gage applications

NASA Astrophysics Data System (ADS)

Ballard, Donna L.; Pilchak, Adam L.

2010-10-01

Precious-metal-modified nickel-based superalloys are being investigated for use in thin gage applications, such as thermal protection systems or heat exchangers, due to their strength and inherent oxidation resistance at temperatures in excess of 1,050°C. This overview paper summarizes the Air Force Research Laboratory (AFRL) interest in experimental two-phase γ-Ni + γ'-Ni3Al superalloys. The AFRL is interested in alloys with a based composition of Ni-15Al-5Cr (at. %) with carbon, boron, and zirconium additions for grain-boundary refinement and strengthening. The alloys currently being evaluated also contain 4-5 at.% of platinum-group metals, in this case platinum and iridium. The feasibility of hot rolling these alloys to a final thickness of 0.12-0.25 mm and obtaining a nearly fully recrystallized microstructure was demonstrated.

Ca2+ current vs. Ca2+ channel cooperativity of exocytosis

PubMed Central

Matveev, Victor; Bertram, Richard; Sherman, Arthur

2009-01-01

Recently there has been significant interest and progress in the study of spatio-temporal dynamics of Ca2+ that triggers exocytosis at a fast chemical synapse, which requires understanding the contribution of individual calcium channels to the release of a single vesicle. Experimental protocols provide insight into this question by probing the sensitivity of exocytosis to Ca2+ influx. While varying extracellular or intracellular Ca2+ concentration assesses the intrinsic biochemical Ca2+ cooperativity of neurotransmitter release, varying the number of open Ca2+ channels using pharmacological channel block or the tail current titration probes the cooperativity between individual Ca2+ channels in triggering exocytosis. Despite the wide use of these Ca2+ sensitivity measurements, their interpretation often relies on heuristic arguments. Here we provide a detailed analysis of the Ca2+ sensitivity measures probed by these experimental protocols, present simple expressions for special cases, and demonstrate the distinction between the Ca2+ current cooperativity, defined by the relationship between exocytosis rate and the whole-terminal Ca2+ current magnitude, and the underlying Ca2+ channel cooperativity, defined as the average number of channels involved in the release of a single vesicle. We find simple algebraic expressions that show that the two are different but linearly related. Further, we use 3D computational modeling of buffered Ca2+ diffusion to analyze these distinct Ca2+ cooperativity measures, and demonstrate the role of endogenous Ca2+ buffers on such measures. We show that buffers can either increase or decrease the Ca2+ current cooperativity of exocytosis, depending on their concentration and the single-channel Ca2+ current. PMID:19793978

Spin Funneling for Enhanced Spin Injection into Ferromagnets

PubMed Central

Sayed, Shehrin; Diep, Vinh Q.; Camsari, Kerem Yunus; Datta, Supriyo

2016-01-01

It is well-established that high spin-orbit coupling (SOC) materials convert a charge current density into a spin current density which can be used to switch a magnet efficiently and there is increasing interest in identifying materials with large spin Hall angle for lower switching current. Using experimentally benchmarked models, we show that composite structures can be designed using existing spin Hall materials such that the effective spin Hall angle is larger by an order of magnitude. The basic idea is to funnel spins from a large area of spin Hall material into a small area of ferromagnet using a normal metal with large spin diffusion length and low resistivity like Cu or Al. We show that this approach is increasingly effective as magnets get smaller. We avoid unwanted charge current shunting by the low resistive NM layer utilizing the newly discovered phenomenon of pure spin conduction in ferromagnetic insulators via magnon diffusion. We provide a spin circuit model for magnon diffusion in FMI that is benchmarked against recent experiments and theory. PMID:27374496

Spin Funneling for Enhanced Spin Injection into Ferromagnets

NASA Astrophysics Data System (ADS)

Sayed, Shehrin; Diep, Vinh Q.; Camsari, Kerem Yunus; Datta, Supriyo

2016-07-01

It is well-established that high spin-orbit coupling (SOC) materials convert a charge current density into a spin current density which can be used to switch a magnet efficiently and there is increasing interest in identifying materials with large spin Hall angle for lower switching current. Using experimentally benchmarked models, we show that composite structures can be designed using existing spin Hall materials such that the effective spin Hall angle is larger by an order of magnitude. The basic idea is to funnel spins from a large area of spin Hall material into a small area of ferromagnet using a normal metal with large spin diffusion length and low resistivity like Cu or Al. We show that this approach is increasingly effective as magnets get smaller. We avoid unwanted charge current shunting by the low resistive NM layer utilizing the newly discovered phenomenon of pure spin conduction in ferromagnetic insulators via magnon diffusion. We provide a spin circuit model for magnon diffusion in FMI that is benchmarked against recent experiments and theory.

On the Maximum and Characteristic Curvature of Current Density of High tc Superconductor Ybco in Flux Relaxation

NASA Astrophysics Data System (ADS)

Ye, Jiping; Sun, Lei; Dai, Xianxi; Dai, Jixin

The flux relaxation is one of important topics in the studies of high Tc superconductivity, because it is related to the energy loss in practical applications. There are many mechanisms, theories and relaxation laws suggested in the literatures. It is very interesting to test them according to the characters and compare them with the experiments. Some people think that the characters of the famous theories are their negative curvature. According our inversion solution, the relaxation ArcG law and experimental data analysis, the relaxation law has both positive and negative signs. This prediction is hopeful to be checked by experiments in future. The current densities of many high Tc superconductors decrease very rapidly in the early time in the relaxation. People do not know what their maximums are. In this work, a theory to determine these maximums of the current densities is presented. The theory is concretely realized by inversion for some real data of the YBCO and their maximum current densities are obtained.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levin, Barnaby D. A.; Padgett, Elliot; Chen, Chien-Chun

Electron tomography in materials science has flourished with the demand to characterize nanoscale materials in three dimensions (3D). Access to experimental data is vital for developing and validating reconstruction methods that improve resolution and reduce radiation dose requirements. This work presents five high-quality scanning transmission electron microscope (STEM) tomography datasets in order to address the critical need for open access data in this field. The datasets represent the current limits of experimental technique, are of high quality, and contain materials with structural complexity. Included are tomographic series of a hyperbranched Co 2 P nanocrystal, platinum nanoparticles on a carbonmore » nanofibre imaged over the complete 180° tilt range, a platinum nanoparticle and a tungsten needle both imaged at atomic resolution by equal slope tomography, and a through-focal tilt series of PtCu nanoparticles. A volumetric reconstruction from every dataset is provided for comparison and development of post-processing and visualization techniques. Researchers interested in creating novel data processing and reconstruction algorithms will now have access to state of the art experimental test data.« less

Experimental observations of a complex, supersonic nozzle concept

NASA Astrophysics Data System (ADS)

Magstadt, Andrew; Berry, Matthew; Glauser, Mark; Ruscher, Christopher; Gogineni, Sivaram; Kiel, Barry; Skytop Turbulence Labs, Syracuse University Team; Spectral Energies, LLC. Team; Air Force Research Laboratory Team

2015-11-01

A complex nozzle concept, which fuses multiple canonical flows together, has been experimentally investigated via pressure, schlieren and PIV in the anechoic chamber at Syracuse University. Motivated by future engine designs of high-performance aircraft, the rectangular, supersonic jet under investigation has a single plane of symmetry, an additional shear layer (referred to as a wall jet) and an aft deck representative of airframe integration. Operating near a Reynolds number of 3 ×106 , the nozzle architecture creates an intricate flow field comprised of high turbulence levels, shocks, shear & boundary layers, and powerful corner vortices. Current data suggest that the wall jet, which is an order of magnitude less energetic than the core, has significant control authority over the acoustic power through some non-linear process. As sound is a direct product of turbulence, experimental and analytical efforts further explore this interesting phenomenon associated with the turbulent flow. The authors acknowledge the funding source, a SBIR Phase II project with Spectral Energies, LLC. and AFRL turbine engine branch under the direction of Dr. Barry Kiel.

Factors Influencing Labeling Nonconsensual Sex as Sexual Assault.

PubMed

Yndo, Monica C; Zawacki, Tina

2017-03-01

The current study examined the effects of physical attractiveness and sexual interest cues on men's sexual perceptions of women and whether increases in sexual perceptions of a woman would lead to decreases in labeling of subsequent nonconsensual sex as sexual assault. Two hundred thirty-three male college students ( M age = 19.17, SD = 1.22) read a vignette describing a hypothetical social interaction between a man and a woman; within the vignette, the female character's physical attractiveness (attractive vs. less attractive) and the degree to which the female character behaved interested in the male character (uninterested vs. ambiguous) were manipulated. The vignette ends with the male character physically forcing sexual intercourse with the female character. After reading the vignette, participants' labeling of the nonconsensual sex as sexual assault was addressed. Participants' perceptions of the female character's sexual interest in the male character prior to the nonconsensual sex was assessed as a dependent variable during stopping points in the vignette, prior to sexual assault. Both physical attractiveness and interest cues had a significant positive influence on men's perception of the female character as sexually interested. In addition, perceptions of sexual interest had a direct negative effect on sexual assault labeling. These results indicate that increases in physical attractiveness and interest cues increase perceptions of sexual interest, in turn decreasing the labeling of nonconsensual sex as sexual assault. This experimental research contributes to the literature on misperception of sexual interest and sexual assault labeling. These findings provide implications for intervention programs and for forensic issues related to sexual assault.

A Novel Particle Swarm Optimization Algorithm for Global Optimization

PubMed Central

Wang, Chun-Feng; Liu, Kui

2016-01-01

Particle Swarm Optimization (PSO) is a recently developed optimization method, which has attracted interest of researchers in various areas due to its simplicity and effectiveness, and many variants have been proposed. In this paper, a novel Particle Swarm Optimization algorithm is presented, in which the information of the best neighbor of each particle and the best particle of the entire population in the current iteration is considered. Meanwhile, to avoid premature, an abandoned mechanism is used. Furthermore, for improving the global convergence speed of our algorithm, a chaotic search is adopted in the best solution of the current iteration. To verify the performance of our algorithm, standard test functions have been employed. The experimental results show that the algorithm is much more robust and efficient than some existing Particle Swarm Optimization algorithms. PMID:26955387

Connections Between Theory and Experiment for Gold and Silver Nanoclusters.

PubMed

Weerawardene, K L Dimuthu M; Häkkinen, Hannu; Aikens, Christine M

2018-04-20

Ligand-stabilized gold and silver nanoparticles are of tremendous current interest in sensing, catalysis, and energy applications. Experimental and theoretical studies have closely interacted to elucidate properties such as the geometric and electronic structures of these fascinating systems. In this review, the interplay between theory and experiment is described; areas such as optical absorption and doping, where the theory-experiment connections are well established, are discussed in detail; and the current status of these connections in newer fields of study, such as luminescence, transient absorption, and the effects of solvent and the surrounding environment, are highlighted. Close communication between theory and experiment has been extremely valuable for developing an understanding of these nanocluster systems in the past decade and will undoubtedly continue to play a major role in future years.

Connections Between Theory and Experiment for Gold and Silver Nanoclusters

NASA Astrophysics Data System (ADS)

Weerawardene, K. L. Dimuthu M.; Häkkinen, Hannu; Aikens, Christine M.

2018-04-01

Ligand-stabilized gold and silver nanoparticles are of tremendous current interest in sensing, catalysis, and energy applications. Experimental and theoretical studies have closely interacted to elucidate properties such as the geometric and electronic structures of these fascinating systems. In this review, the interplay between theory and experiment is described; areas such as optical absorption and doping, where the theory-experiment connections are well established, are discussed in detail; and the current status of these connections in newer fields of study, such as luminescence, transient absorption, and the effects of solvent and the surrounding environment, are highlighted. Close communication between theory and experiment has been extremely valuable for developing an understanding of these nanocluster systems in the past decade and will undoubtedly continue to play a major role in future years.

Direct measurement of interfilament resistance in Nb3Sn strands

NASA Astrophysics Data System (ADS)

Corato, V.; Muzzi, L.; Vetrella, U. Besi; della Corte, A.

2009-05-01

In modeling the properties of superconducting multifilamentary strands, transverse resistivity plays a crucial role in the definition of the coupling losses in ac regime, as well as of the current transfer length, that affects the transport properties of Nb3Sn wires subject to bending strain. We present the first direct measurement of the interfilament transverse resistance in superconducting strands from room temperature to 4.2 K. Results have been compared to the transverse resistance of a sample on which the outer copper stabilization layer has been removed by chemical etching, obtaining interesting indication on the preferential current paths within the wire cross section. An excellent agreement between experimental data and theoretical models has been found in describing the whole strand, while improvements are required in modeling the filamentary region alone.

Clinical and experimental applications of sodium phenylbutyrate.

PubMed

Iannitti, Tommaso; Palmieri, Beniamino

2011-09-01

Histone acetyltransferase and histone deacetylase are enzymes responsible for histone acetylation and deacetylation, respectively, in which the histones are acetylated and deacetylated on lysine residues in the N-terminal tail and on the surface of the nucleosome core. These processes are considered the most important epigenetic mechanisms for remodeling the chromatin structure and controlling the gene expression. Histone acetylation is associated with gene activation. Sodium phenylbutyrate is a histone deacetylase inhibitor that has been approved for treatement of urea cycle disorders and is under investigation in cancer, hemoglobinopathies, motor neuron diseases, and cystic fibrosis clinical trials. Due to its characteristics, not only of histone deacetylase inhibitor, but also of ammonia sink and chemical chaperone, the interest towards this molecule is growing worldwide. This review aims to update the current literature, involving the use of sodium phenylbutyrate in experimental studies and clinical trials.

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

26 CFR 1.471-11 - Inventories of manufacturers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... expenses, (d) Other distribution expenses, (e) Interest, (f) Research and experimental expenses including... the taxpayer, notwithstanding the provisions of § 1.481-1(c)(5). Thus, any of the taxpayer's “pre-1954...

Time-frequency vibration analysis for the detection of motor damages caused by bearing currents

NASA Astrophysics Data System (ADS)

Prudhom, Aurelien; Antonino-Daviu, Jose; Razik, Hubert; Climente-Alarcon, Vicente

2017-02-01

Motor failure due to bearing currents is an issue that has drawn an increasing industrial interest over recent years. Bearing currents usually appear in motors operated by variable frequency drives (VFD); these drives may lead to common voltage modes which cause currents induced in the motor shaft that are discharged through the bearings. The presence of these currents may lead to the motor bearing failure only few months after system startup. Vibration monitoring is one of the most common ways for detecting bearing damages caused by circulating currents; the evaluation of the amplitudes of well-known characteristic components in the vibration Fourier spectrum that are associated with race, ball or cage defects enables to evaluate the bearing condition and, hence, to identify an eventual damage due to bearing currents. However, the inherent constraints of the Fourier transform may complicate the detection of the progressive bearing degradation; for instance, in some cases, other frequency components may mask or be confused with bearing defect-related while, in other cases, the analysis may not be suitable due to the eventual non-stationary nature of the captured vibration signals. Moreover, the fact that this analysis implies to lose the time-dimension limits the amount of information obtained from this technique. This work proposes the use of time-frequency (T-F) transforms to analyse vibration data in motors affected by bearing currents. The experimental results obtained in real machines show that the vibration analysis via T-F tools may provide significant advantages for the detection of bearing current damages; among other, these techniques enable to visualise the progressive degradation of the bearing while providing an effective discrimination versus other components that are not related with the fault. Moreover, their application is valid regardless of the operation regime of the machine. Both factors confirm the robustness and reliability of these tools that may be an interesting alternative for detecting this type of failure in induction motors.

Laser induced photoluminiscence studies of primary photochemical production processes of cometary radicals

NASA Technical Reports Server (NTRS)

Jackson, W. M.

1977-01-01

A tunable vacuum ultraviolet flash lamp was constructed. This unique flash lamp was coupled with a tunable dye laser detector and permits the experimenter to measure the production rates of ground state radicals as a function of wavelength. A new technique for producing fluorescent radicals was discovered. This technique called multiphoton ultraviolet photodissociation is currently being applied to several problems of both cometary and stratospheric interest. It was demonstrated that NO2 will dissociate to produce an excited fragment and the radiation can possibly be used for remote detection of this species.

Physics and Physics Education at Clarion University

NASA Astrophysics Data System (ADS)

Aravind, Vasudeva

Clarion University is located in the rolling hills of western Pennsylvania. We are a primarily undergraduate public institution serving about 6000 students. We graduate students who take different career paths, one of them being teaching physics at high schools. Since educating teachers of tomorrow requires us to introduce currently trending, research proven pedagogical methods, we incorporate several aspects of physics pedagogies such as peer instruction, flipped classroom and hands on experimentation in a studio physics lab format. In this talk, I discuss some of our projects on physics education, and seek to find potential collaborators interested in working along similar lines.

Research in progress and other activities of the Institute for Computer Applications in Science and Engineering

NASA Technical Reports Server (NTRS)

1993-01-01

This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics and computer science during the period April 1, 1993 through September 30, 1993. The major categories of the current ICASE research program are: (1) applied and numerical mathematics, including numerical analysis and algorithm development; (2) theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustic and combustion; (3) experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and (4) computer science.

Strangeness from SPS to FAIR: Searching for the onset of deconfinement

NASA Astrophysics Data System (ADS)

Friese, Volker

2017-12-01

Since the early days of heavy-ion physics, strangeness has been considered a sensitive probe of the state of matter created in nuclear collisions. This assessment still holds today, where we are witnessing renewed interest in collisions at moderate energies, manifested in the running or projected experimental programmes at RHIC, SPS, FAIR, and NICA. In this article, we will review the current understanding of strangeness production at lower energies and discuss how far future measurement of strange particles can contribute to understanding the properties of dense QCD matter and to the search for the onset of deconfinement.

Paraxial ray optics cloaking.

PubMed

Choi, Joseph S; Howell, John C

2014-12-01

Despite much interest and progress in optical spatial cloaking, a three-dimensional (3D), transmitting, continuously multidirectional cloak in the visible regime has not yet been demonstrated. Here we experimentally demonstrate such a cloak using ray optics, albeit with some edge effects. Our device requires no new materials, uses isotropic off-the-shelf optics, scales easily to cloak arbitrarily large objects, and is as broadband as the choice of optical material, all of which have been challenges for current cloaking schemes. In addition, we provide a concise formalism that quantifies and produces perfect optical cloaks in the small-angle ('paraxial') limit.

Simple refractometer based on in-line fiber interferometers

NASA Astrophysics Data System (ADS)

Esteban, Ó.; Martínez Manuel, R.; Shlyagin, M. G.

2015-09-01

A very simple but accurate optical fiber refractometer based on the Fresnel reflection in the fiber tip and two in-line low-reflective mirrors for light intensity referencing is reported. Each mirror was generated by connecting together 2 fiber sections with FC/PC and FC/APC connectors using the standard FC/PC mating sleeve. For the sensor interrogation, a standard DFB diode laser pumped with a sawtooth-wave current was used. A resolution of 6 x 10-4 was experimentally demonstrated using different liquids. A simple sensor construction and the use of low cost components make the reported system interesting for many applications.

Research in progress in applied mathematics, numerical analysis, fluid mechanics, and computer science

NASA Technical Reports Server (NTRS)

1994-01-01

This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period October 1, 1993 through March 31, 1994. The major categories of the current ICASE research program are: (1) applied and numerical mathematics, including numerical analysis and algorithm development; (2) theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustics and combustion; (3) experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and (4) computer science.

Comparison of the surface dielectric barrier discharge characteristics under different electrode gaps

NASA Astrophysics Data System (ADS)

Gao, Guoqiang; Dong, Lei; Peng, Kaisheng; Wei, Wenfu; Li, Chunmao; Wu, Guangning

2017-01-01

Currently, great interests are paid to the surface dielectric barrier discharge due to the diverse and interesting application. In this paper, the influences of the electrode gap on the discharge characteristics have been studied. Aspects of the electrical parameters, the optical emission, and the discharge induced gas flow were considered. The electrode gap varied from 0 mm to 21 mm, while the applied AC voltage was studied in the range of 17 kV-27 kV. Results indicate that with the increase of the electrode gap, the variation of discharge voltage exhibits an increasing trend, while the other parameters (i.e., the current, power, and induced flow velocity) increase first, and then decrease once the gap exceeded the critical value. Mechanisms of the electrode gap influencing these key parameters were discussed from the point of equivalent circuit. The experimental results reveal that an optimal discharge gap can be obtained, which is closely related to the applied voltage. Visualization of the induced flow with different electrode gaps was realized by the Schlieren diagnostic technique. Finally, the velocities of induced gas flow determined by the pitot tube were compared with the results of intensity-integral method, and good agreements were found.

A Bayesian hierarchical diffusion model decomposition of performance in Approach–Avoidance Tasks

PubMed Central

Krypotos, Angelos-Miltiadis; Beckers, Tom; Kindt, Merel; Wagenmakers, Eric-Jan

2015-01-01

Common methods for analysing response time (RT) tasks, frequently used across different disciplines of psychology, suffer from a number of limitations such as the failure to directly measure the underlying latent processes of interest and the inability to take into account the uncertainty associated with each individual's point estimate of performance. Here, we discuss a Bayesian hierarchical diffusion model and apply it to RT data. This model allows researchers to decompose performance into meaningful psychological processes and to account optimally for individual differences and commonalities, even with relatively sparse data. We highlight the advantages of the Bayesian hierarchical diffusion model decomposition by applying it to performance on Approach–Avoidance Tasks, widely used in the emotion and psychopathology literature. Model fits for two experimental data-sets demonstrate that the model performs well. The Bayesian hierarchical diffusion model overcomes important limitations of current analysis procedures and provides deeper insight in latent psychological processes of interest. PMID:25491372

Focal cryotherapy for prostate cancer.

PubMed

Tsivian, Matvey; Polascik, Thomas J

2010-05-01

Focal therapy for prostate cancer has emerged an interesting concept as a less morbid option for the treatment of localized low-risk disease. Despite the growing interest in focal therapy, this approach has not yet gained sufficient popularity nor provided enough data to be discussed outside the experimental application. Herein we summarize the available data on focal cryotherapy and focus on the targets to be achieved in order to increase the applicability of focal cryotherapy to clinical practice. A cautious approach to candidate selection and generation of solid scientific data that would result in wide consensus on patient selection strategies and follow-up schemes would provide the tools necessary to take the path of focal therapy. Currently available focal cryotherapy data demonstrate excellent short-term results and a favorable quality-of-life profile. Although the future role of focal treatment is debated, a growing amount of science is generated in support of this minimally invasive approach.

Quantum information processing with superconducting circuits: a review.

PubMed

Wendin, G

2017-10-01

During the last ten years, superconducting circuits have passed from being interesting physical devices to becoming contenders for near-future useful and scalable quantum information processing (QIP). Advanced quantum simulation experiments have been shown with up to nine qubits, while a demonstration of quantum supremacy with fifty qubits is anticipated in just a few years. Quantum supremacy means that the quantum system can no longer be simulated by the most powerful classical supercomputers. Integrated classical-quantum computing systems are already emerging that can be used for software development and experimentation, even via web interfaces. Therefore, the time is ripe for describing some of the recent development of superconducting devices, systems and applications. As such, the discussion of superconducting qubits and circuits is limited to devices that are proven useful for current or near future applications. Consequently, the centre of interest is the practical applications of QIP, such as computation and simulation in Physics and Chemistry.

Quantum information processing with superconducting circuits: a review

NASA Astrophysics Data System (ADS)

Wendin, G.

2017-10-01

During the last ten years, superconducting circuits have passed from being interesting physical devices to becoming contenders for near-future useful and scalable quantum information processing (QIP). Advanced quantum simulation experiments have been shown with up to nine qubits, while a demonstration of quantum supremacy with fifty qubits is anticipated in just a few years. Quantum supremacy means that the quantum system can no longer be simulated by the most powerful classical supercomputers. Integrated classical-quantum computing systems are already emerging that can be used for software development and experimentation, even via web interfaces. Therefore, the time is ripe for describing some of the recent development of superconducting devices, systems and applications. As such, the discussion of superconducting qubits and circuits is limited to devices that are proven useful for current or near future applications. Consequently, the centre of interest is the practical applications of QIP, such as computation and simulation in Physics and Chemistry.

One-dimensional quantum matter: gold-induced nanowires on semiconductor surfaces

NASA Astrophysics Data System (ADS)

Dudy, L.; Aulbach, J.; Wagner, T.; Schäfer, J.; Claessen, R.

2017-11-01

Interacting electrons confined to only one spatial dimension display a wide range of unusual many-body quantum phenomena, ranging from Peierls instabilities to the breakdown of the canonical Fermi liquid paradigm to even unusual spin phenomena. The underlying physics is not only of tremendous fundamental interest, but may also have bearing on device functionality in future micro- and nanoelectronics with lateral extensions reaching the atomic limit. Metallic adatoms deposited on semiconductor surfaces may form self-assembled atomic nanowires, thus representing highly interesting and well-controlled solid-state realizations of such 1D quantum systems. Here we review experimental and theoretical investigations on a few selected prototypical nanowire surface systems, specifically Ge(0 0 1)-Au and Si(hhk)-Au, and the search for 1D quantum states in them. We summarize the current state of research and identify open questions and issues.

75 FR 13208 - Proposed Collection; Comment Request for Revenue Procedure 2006-42

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... to the Apportionment of Interest Expense, Research and Experimental Expenditures Under Section 1.861... Certain Elections Relating to the Apportionment of Interest Expense, Research and Experimental... automatic consent to change (a) from the fair market value method or from the alternative tax book method to...

Robotic Cooperative Learning Promotes Student STEM Interest

ERIC Educational Resources Information Center

Mosley, Pauline; Ardito, Gerald; Scollins, Lauren

2016-01-01

The principal purpose of this investigation is to study the effect of robotic cooperative learning methodologies on middle school students' critical thinking, and STEM interest. The semi-experimental inquiry consisted of ninety four six-grade students (forty nine students in the experimental group, forty five students in the control group), chosen…

Measurement Requirements for Improved Modeling of Arcjet Facility Flows

NASA Technical Reports Server (NTRS)

Fletcher, Douglas G.

2000-01-01

Current efforts to develop new reusable launch vehicles and to pursue low-cost robotic planetary missions have led to a renewed interest in understanding arc-jet flows. Part of this renewed interest is concerned with improving the understanding of arc-jet test results and the potential use of available computational-fluid- dynamic (CFD) codes to aid in this effort. These CFD codes have been extensively developed and tested for application to nonequilibrium, hypersonic flow modeling. It is envisioned, perhaps naively, that the application of these CFD codes to the simulation of arc-jet flows would serve two purposes: first. the codes would help to characterize the nonequilibrium nature of the arc-jet flows; and second. arc-jet experiments could potentially be used to validate the flow models. These two objectives are, to some extent, mutually exclusive. However, the purpose of the present discussion is to address what role CFD codes can play in the current arc-jet flow characterization effort, and whether or not the simulation of arc-jet facility tests can be used to eva1uate some of the modeling that is used to formu1ate these codes. This presentation is organized into several sections. In the introductory section, the development of large-scale, constricted-arc test facilities within NASA is reviewed, and the current state of flow diagnostics using conventional instrumentation is summarized. The motivation for using CFD to simulate arc-jet flows is addressed in the next section, and the basic requirements for CFD models that would be used for these simulations are briefly discussed. This section is followed by a more detailed description of experimental measurements that are needed to initiate credible simulations and to evaluate their fidelity in the different flow regions of an arc-jet facility. Observations from a recent combined computational and experiment.al investigation of shock-layer flows in a large-scale arc-jet facility are then used to illustrate the current state of development of diagnostic instrumentation, CFD simulations, and general knowledge in the field of arc-jet characterization. Finally, the main points are summarized and recommendations for future efforts are given.

Electrical and hydrodynamic characterization of a high current pulsed arc

NASA Astrophysics Data System (ADS)

Sousa Martins, R.; Chemartin, L.; Zaepffel, C.; Lalande, Ph; Soufiani, A.

2016-05-01

High current pulsed arcs are of significant industrial interest and, aiming to reduce time and cost, there is progressively more and more need for computation tools that describe and predict the behaviour of these arcs. These simulation codes need inputs and validations by experimental databases, but accurate data is missing for this category of electric discharges. The principal lack of understanding is with respect to the transient phase of the current, which can reach thousands of amperes in a few microseconds. In this paper, we present the work realized on an experimental setup that simulates in the laboratory an arc column subjected to five levels of high pulsed current, ranging from 10 kA to 100 kA, with the last one corresponding to the standard lightning current waveform used in aircraft certification processes. This device was instrumented by high speed video cameras to assess the characteristic sizes of the arc channel and to characterize the shock wave generated by the arc expansion. The arc channel radius was measured over time during the axisymmetric phase and reached 3.2 cm. The position and velocity of the shock wave was determined during the first 140 μs. The background-oriented schlieren method was used to study the shock wave and a model for the light deflection inside the shock wave was developed. The mass density profile of the shock wave was estimated and showed good agreement with Rankine-Hugoniot relations at the wave front. Electrical measurements were also used to estimate the time-dependent resistance and conductivity of the arc for times lasting up to 50 μs.

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

PubMed Central

Kilgore, Kevin L.; Bhadra, Niloy

2013-01-01

Objectives The features and clinical applications of balanced-charge kilohertz frequency alternating currents (KHFAC) are reviewed. Preclinical studies of KHFAC block have demonstrated that it can produce an extremely rapid and reversible block of nerve conduction. Recent systematic analysis and experimentation utilizing KHFAC block has resulted in a significant increase in interest in KHFAC block, both scientifically and clinically. Materials and Methods We review the history and characteristics of KHFAC block, the methods used to investigate this type of block, the experimental evaluation of block, and the electrical parameters and electrode designs needed to achieve successful block. We then analyze the existing clinical applications of high frequency currents, comparing the early results with the known features of KHFAC block. Results Although many features of KHFAC block have been characterized, there is still much that is unknown regarding the response of neural structures to rapidly fluctuating electrical fields. The clinical reports to date do not provide sufficient information to properly evaluate the mechanisms that result in successful or unsuccessful treatment. Conclusions KHFAC nerve block has significant potential as a means of controlling nerve activity for the purpose of treating disease. However, early clinical studies in the use of high frequency currents for the treatment of pain have not been designed to elucidate mechanisms or allow direct comparisons to preclinical data. We strongly encourage the careful reporting of the parameters utilized in these clinical studies, as well as the development of outcome measures that could illuminate the mechanisms of this modality. PMID:23924075

An experimental investigation of emotional reasoning processes in depression.

PubMed

Berle, David; Moulds, Michelle L

2013-09-01

Cognitive models of depression emphasize how distorted thoughts and interpretations contribute to low mood. Emotional reasoning is considered to be one such interpretative style. We used an experimental procedure to determine whether elevated levels of emotional reasoning characterize depression. Participants who were currently experiencing a major depressive episode (n = 27) were compared with those who were non-depressed (n = 25 who had never been depressed and n = 26 previously but not currently depressed) on an emotional reasoning task. Although there were some trends for depressed participants to show greater levels of emotional reasoning relative to non-depressed participants, none of these differences attained significance. Interestingly, previously depressed participants engaged in more non-self-referent emotional reasoning than never-depressed participants. Emotional reasoning does not appear to characterize mild to moderate levels of depression. The lack of significant differences in emotional reasoning between currently depressed and non-depressed participants may have been a consequence of the fact that participants in our currently depressed group were, for the most part, only mildly depressed. Non-self-referent emotional reasoning may nevertheless be a risk factor for subsequent depressive episodes, or else serve as a 'cognitive scar' from previous episodes. In contrast with the predictions of cognitive models of depression, emotional reasoning tendencies may not be especially prominent in currently depressed individuals. Depressed individuals vary greatly in the degree to which they engage in emotional reasoning. Individuals with remitted depression may show elevated of levels non-self-referent emotional reasoning compared with those who have never had a depressive episode, that is, rely on their emotions when forming interpretations about situations. Our findings require replication using alternative indices of emotional reasoning. Our currently depressed individuals were only mildly clinically depressed precluding conclusions about individuals with more severe levels of depression. © 2013 The British Psychological Society.

Dynamic modeling for flow-activated chloride-selective membrane current in vascular endothelial cells.

PubMed

Qin, Kai-Rong; Xiang, Cheng; Cao, Ling-Ling

2011-10-01

In this paper, a dynamic model is proposed to quantify the relationship between fluid flow and Cl(-)-selective membrane current in vascular endothelial cells (VECs). It is assumed that the external shear stress would first induce channel deformation in VECs. This deformation could activate the Cl(-) channels on the membrane, thus allowing Cl(-) transport across the membrane. A modified Hodgkin-Huxley model is embedded into our dynamic system to describe the electrophysiological properties of the membrane, such as the Cl(-)-selective membrane current (I), voltage (V) and conductance. Three flow patterns, i. e., steady flow, oscillatory flow, and pulsatile flow, are applied in our simulation studies. When the extracellular Cl(-) concentration is constant, the I-V characteristics predicted by our dynamic model shows strong consistency with the experimental observations. It is also interesting to note that the Cl(-) currents under different flow patterns show some differences, indicating that VECs distinguish among and respond differently to different types of flows. When the extracellular Cl(-) concentration keeps constant or varies slowly with time (i.e. oscillates at 0.02 Hz), the convection and diffusion of Cl(-) in extracellular space can be ignored and the Cl(-) current is well captured by the modified Hodgkin-Huxley model alone. However, when the extracellular Cl(-) varies fast (i.e., oscillates at 0.2 Hz), the convection and diffusion effect should be considered because the Cl(-) current dynamics is different from the case where the convection-diffusion effect is simply ignored. The proposed dynamic model along with the simulation results could not only provide more insights into the flow-regulated electrophysiological behavior of the cell membrane but also help to reveal new findings in the electrophysiological experimental investigations of VECs in response to dynamic flow and biochemical stimuli.

The dual-basin landscape in GFP folding

PubMed Central

Andrews, Benjamin T.; Gosavi, Shachi; Finke, John M.; Onuchic, José N.; Jennings, Patricia A.

2008-01-01

Recent experimental studies suggest that the mature GFP has an unconventional landscape composed of an early folding event with a typical funneled landscape, followed by a very slow search and rearrangement step into the locked, active chromophore-containing structure. As we have shown previously, the substantial difference in time scales is what generates the observed hysteresis in thermodynamic folding. The interconversion between locked and the soft folding structures at intermediate denaturant concentrations is so slow that it is not observed under the typical experimental observation time. Simulations of a coarse-grained model were used to describe the fast folding event as well as identify native-like intermediates on energy landscapes enroute to the fluorescent native fold. Interestingly, these simulations reveal structural features of the slow dynamic transition to chromophore activation. Experimental evidence presented here shows that the trapped, native-like intermediate has structural heterogeneity in residues previously linked to chromophore formation. We propose that the final step of GFP folding is a “locking” mechanism leading to chromophore formation and high stability. The combination of previous experimental work and current simulation work is explained in the context of a dual-basin folding mechanism described above. PMID:18713871

Interests, Self-Efficacy, and Choice Goals: An Experimental Manipulation

ERIC Educational Resources Information Center

Bonitz, Verena S.; Larson, Lisa M.; Armstrong, Patrick Ian

2010-01-01

An experimental design was used to test the hypothesis that vocational interests can be a precursor to the development of self-efficacy. Participants (n = 180) rated job descriptions for careers in the domains of information technology, sales, and teaching that contained information on activities and work values. Participants rated those job…

Studies of self-pollution in diesel school buses: methodological issues.

PubMed

Borak, Jonathan; Sirianni, Greg

2007-09-01

Considerable interest has focused on levels of exhaust emissions in the cabins of diesel-powered school buses and their possible adverse health effects. Significantly different policy and engineering issues would be raised if compelling evidence found that inc-cabin contamination was due to self-pollution from bus emissions, rather than ambient pollution, neighboring vehicles, and/or re-entrained road dust. We identified 19 reports from 11 studies that measured diesel exhaust particulate in the cabins of 58 school bus of various type. Studies were evaluated in light of their experimental design, their data quality, and their capacity to quantify self-pollution. Only one study had a true experimental design, comparing the same buses with and without emission controls, while four others used intentional tracers to quantify tail pipe and/or crankcase emissions. Although definitive data are still lacking, these studies suggest that currently available control technologies can nearly eliminate particulate self-pollution inside diesel school buses.

Advanced ab initio relativistic calculations of transition probabilities for some O I and O III emission lines

NASA Astrophysics Data System (ADS)

Nguyen, T. V. B.; Chantler, C. T.; Lowe, J. A.; Grant, I. P.

2014-06-01

This work presents new ab initio relativistic calculations using the multiconfiguration Dirac-Hartree-Fock method of some O I and O III transition lines detected in B-type and Wolf-Rayet stars. Our results are the first able to be presented in both the length and velocity gauges, with excellent gauge convergence. Compared to previous experimental and theoretical uncertainties of up to 50 per cent, our accuracies appear to be in the range of 0.33-5.60 per cent, with gauge convergence up to 0.6 per cent. Similar impressive convergence of the calculated energies is also shown. Two sets of theoretical computations are compared with earlier tabulated measurements. Excellent agreement is obtained with one set of transitions but an interesting and consistent discrepancy exists between the current work and the prior literature, deserving of future experimental studies.

The aging correlation (RH + t): Relative humidity (%) + temperature (deg C)

NASA Technical Reports Server (NTRS)

Cuddihy, E. F.

1986-01-01

An aging correlation between corrosion lifetime, and relative humidity RH (%) and temperature t (C) has been reported in the literature. This aging correlation is a semi-log plot of corrosion lifetime on the log scale versus the interesting summation term RH(%) + t(C) on the linear scale. This empirical correlation was derived from observation of experimental data trends and has been referred to as an experimental law. Using electrical resistivity data of polyvinyl butyral (PVB) measured as a function of relative humidity and temperature, it was found that the electrical resistivity could be expressed as a function of the term RH(%) t(C). Thus, if corrosion is related to leakage current through an organic insulator, which, in turn, is a function of RH and t, then some partial theoretical validity for the correlation is indicated. This article describes the derivation of the term RH(%) t(C) from PVB electrical resistivity data.

Right to experimental treatment: FDA new drug approval, constitutional rights, and the public's health.

PubMed

Leonard, Elizabeth Weeks

2009-01-01

On May 2, 2006, a divided panel of the U.S. Court of Appeals for the District of Columbia, in a startling opinion, Abigail Alliance for Better Access to Developmental Drugs v. Eschenbach, held that terminally ill patients who have exhausted all other available options have a constitutional right to experimental treatment that FDA has not yet approved. Although ultimately overturned by the full court, Abigail Alliance generated considerable interest from various constituencies. Meanwhile, FDA proposed similar regulatory amendments, as have lawmakers on both sides of the aisle in Congress. But proponents of expanded access fail to consider public health and consumer safety concerns. In particular, allowing patients to try unproven treatments, outside of controlled clinical trials risks both the study's outcome and the health of patients who might benefit from the deliberate, careful process of new drug approval as it currently operates under FDA's auspices.

On the Measurement of Power Law Creep Parameters from Instrumented Indentation

NASA Astrophysics Data System (ADS)

Sudharshan Phani, P.; Oliver, W. C.; Pharr, G. M.

2017-11-01

Recently the measurement of the creep response of materials at small scales has received renewed interest largely because the equipment required to perform high-temperature nanomechanical testing has become available to an increasing number of researchers. Despite that increased access, there remain several significant experimental and modeling challenges in small-scale mechanical testing at elevated temperatures that are as yet unresolved. In this regard, relating the creep response observed with high-temperature instrumented indentation experiments to macroscopic uniaxial creep response is of great practical value. In this review, we present an overview of various methods currently being used to measure creep with instrumented indentation, with a focus on geometrically self-similar indenters, and their relative merits and demerits from an experimental perspective. A comparison of the various methods to use those instrumented indentation results to predict the uniaxial power law creep response of a wide range of materials will be presented to assess their validity.

Hot-carrier-induced current capability degradation and optimization for lateral IGBT on thick SOI substrate

NASA Astrophysics Data System (ADS)

Zhang, Chunwei; Li, Yang; Yue, Wenjing; Fu, Xiaoqian; Li, Zhiming

2018-07-01

In this paper, the hot-carrier-induced current capability degradation of a 600 V lateral insulated gate bipolar transistor (LIGBT) on thick silicon on insulator (SOI) substrate is investigated. Our experiments found that, for the SOI-LIGBT, the worst stress condition is the maximum gate voltage (Vgmax) condition and the current degradation is dominated by the damages in the channel region under the Vgmax stress condition. However, further analyses show that the influence of channel region damages on the collector current degradation increases with the increase of measured collector voltage and is maximum in the current saturation region. Therefore, in our opinion, the hot-carrier-induced current capability degradation of the SOI-LIGBT should be evaluated by the degradation of saturation current under the Vgmax stress condition. In addition, a novel SOI-LIGBT structure with an external p-type region was also proposed, which can alleviate the damage in the channel region by reducing the lateral electric field peak. Our experimental results demonstrate that the proposed structure could optimize the hot-carrier reliability effectively with the other characteristics maintained. He is currently a lecturer at the University of Jinan, Jinan, China. His research interests include power electronics, high voltage devices and the electronics reliability.

A State-of-the-Art Experimental Laboratory for Cloud and Cloud-Aerosol Interaction Research

NASA Technical Reports Server (NTRS)

Fremaux, Charles M.; Bushnell, Dennis M.

2011-01-01

The state of the art for predicting climate changes due to increasing greenhouse gasses in the atmosphere with high accuracy is problematic. Confidence intervals on current long-term predictions (on the order of 100 years) are so large that the ability to make informed decisions with regard to optimum strategies for mitigating both the causes of climate change and its effects is in doubt. There is ample evidence in the literature that large sources of uncertainty in current climate models are various aerosol effects. One approach to furthering discovery as well as modeling, and verification and validation (V&V) for cloud-aerosol interactions is use of a large "cloud chamber" in a complimentary role to in-situ and remote sensing measurement approaches. Reproducing all of the complex interactions is not feasible, but it is suggested that the physics of certain key processes can be established in a laboratory setting so that relevant fluid-dynamic and cloud-aerosol phenomena can be experimentally simulated and studied in a controlled environment. This report presents a high-level argument for significantly improved laboratory capability, and is meant to serve as a starting point for stimulating discussion within the climate science and other interested communities.

Microgravity combustion science: Progress, plans, and opportunities

NASA Technical Reports Server (NTRS)

1992-01-01

An earlier overview is updated which introduced the promise of microgravity combustion research and provided a brief survey of results and then current research participants, the available set of reduced gravity facilities, and plans for experimental capabilities in the space station era. Since that time, several research studies have been completed in drop towers and aircraft, and the first space based combustion experiments since Skylab have been conducted on the Shuttle. The microgravity environment enables a new range of experiments to be performed since buoyancy induced flows are nearly eliminated, normally obscured forces and flows may be isolated, gravitational settling or sedimentation is nearly eliminated, and larger time or length scales in experiments are feasible. In addition to new examinations of classical problems, (e.g., droplet burning), current areas of interest include soot formation and weak turbulence, as influenced by gravity.

Sub-100 fJ and sub-nanosecond thermally driven threshold switching in niobium oxide crosspoint nanodevices.

PubMed

Pickett, Matthew D; Williams, R Stanley

2012-06-01

We built and measured the dynamical current versus time behavior of nanoscale niobium oxide crosspoint devices which exhibited threshold switching (current-controlled negative differential resistance). The switching speeds of 110 × 110 nm(2) devices were found to be Δt(ON) = 700 ps and Δt(OFF) = 2:3 ns while the switching energies were of the order of 100 fJ. We derived a new dynamical model based on the Joule heating rate of a thermally driven insulator-to-metal phase transition that accurately reproduced the experimental results, and employed the model to estimate the switching time and energy scaling behavior of such devices down to the 10 nm scale. These results indicate that threshold switches could be of practical interest in hybrid CMOS nanoelectronic circuits.

Interfacial states and far-from-equilibrium transitions in the epitaxial growth and erosion on (110) crystal surfaces

NASA Astrophysics Data System (ADS)

Levandovsky, Artem; Golubović, Leonardo; Moldovan, Dorel

2006-12-01

We discuss the far-from-equilibrium interfacial phenomena occurring in the multilayer homoepitaxial growth and erosion on (110) crystal surfaces. Experimentally, these rectangular symmetry surfaces exhibit a multitude of interesting nonequilibrium interfacial structures, such as the rippled one-dimensional periodic states that are not present in the homoepitaxial growth and erosion on the high symmetry (100) and (111) crystal surfaces. Within a unified phenomenological model, we reveal and elucidate this multitude of states on (110) surfaces as well as the transitions between them. By analytic arguments and numerical simulations, we address experimentally observed transitions between two types of rippled states on (110) surfaces. We discuss several intermediary interface states intervening, via consecutive transitions, between the two rippled states. One of them is the rhomboidal pyramid state, theoretically predicted by Golubovic [Phys. Rev. Lett. 89, 266104 (2002)] and subsequently seen, by de Mongeot and co-workers, in the epitaxial erosion of Cu(110) and Rh(110) surfaces [A. Molle , Phys. Rev. Lett. 93, 256103 (2004), and A. Molle , Phys. Rev. B 73, 155418 (2006)]. In addition, we find a number of interesting intermediary states having structural properties somewhere between those of rippled and pyramidal states. Prominent among them are the rectangular rippled states of long rooflike objects (huts) recently seen on Ag(110) surface. We also predict the existence of a striking interfacial structure that carries nonzero, persistent surface currents. Periodic surface currents vortex lattice formed in this so-called buckled rippled interface state is a far-from-equilibrium relative of the self-organized convective flow patterns in hydrodynamic systems. We discuss the coarsening growth of the multitude of the interfacial states on (110) crystal surfaces.

Methodological quality of meta-analyses of single-case experimental studies.

PubMed

Jamshidi, Laleh; Heyvaert, Mieke; Declercq, Lies; Fernández-Castilla, Belén; Ferron, John M; Moeyaert, Mariola; Beretvas, S Natasha; Onghena, Patrick; Van den Noortgate, Wim

2017-12-28

Methodological rigor is a fundamental factor in the validity and credibility of the results of a meta-analysis. Following an increasing interest in single-case experimental design (SCED) meta-analyses, the current study investigates the methodological quality of SCED meta-analyses. We assessed the methodological quality of 178 SCED meta-analyses published between 1985 and 2015 through the modified Revised-Assessment of Multiple Systematic Reviews (R-AMSTAR) checklist. The main finding of the current review is that the methodological quality of the SCED meta-analyses has increased over time, but is still low according to the R-AMSTAR checklist. A remarkable percentage of the studies (93.80% of the included SCED meta-analyses) did not even reach the midpoint score (22, on a scale of 0-44). The mean and median methodological quality scores were 15.57 and 16, respectively. Relatively high scores were observed for "providing the characteristics of the included studies" and "doing comprehensive literature search". The key areas of deficiency were "reporting an assessment of the likelihood of publication bias" and "using the methods appropriately to combine the findings of studies". Although the results of the current review reveal that the methodological quality of the SCED meta-analyses has increased over time, still more efforts are needed to improve their methodological quality. Copyright © 2017 Elsevier Ltd. All rights reserved.

Animal behavioral assessments in current research of Parkinson's disease.

PubMed

Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Hong, Zhen; Yang, Yilin; Hua, Fei; Ding, Guanghong; Chao, Dongman; Fenoy, Albert J; Villarreal, Sebastian J; Onoe, Hirotaka; Suzuki, Katsuaki; Mori, Norio; Namba, Hiroki; Xia, Ying

2016-06-01

Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research. Copyright © 2016 Elsevier Ltd. All rights reserved.

A High Efficiency Boost Converter with MPPT Scheme for Low Voltage Thermoelectric Energy Harvesting

NASA Astrophysics Data System (ADS)

Guan, Mingjie; Wang, Kunpeng; Zhu, Qingyuan; Liao, Wei-Hsin

2016-11-01

Using thermoelectric elements to harvest energy from heat has been of great interest during the last decade. This paper presents a direct current-direct current (DC-DC) boost converter with a maximum power point tracking (MPPT) scheme for low input voltage thermoelectric energy harvesting applications. Zero current switch technique is applied in the proposed MPPT scheme. Theoretical analysis on the converter circuits is explored to derive the equations for parameters needed in the design of the boost converter. Simulations and experiments are carried out to verify the theoretical analysis and equations. A prototype of the designed converter is built using discrete components and a low-power microcontroller. The results show that the designed converter can achieve a high efficiency at low input voltage. The experimental efficiency of the designed converter is compared with a commercial converter solution. It is shown that the designed converter has a higher efficiency than the commercial solution in the considered voltage range.

Theoretical Characterizaiton of Visual Signatures (Muzzle Flash)

NASA Astrophysics Data System (ADS)

Kashinski, D. O.; Scales, A. N.; Vanderley, D. L.; Chase, G. M.; di Nallo, O. E.; Byrd, E. F. C.

2014-05-01

We are investigating the accuracy of theoretical models used to predict the visible, ultraviolet and infrared spectra of product materials ejected from the muzzle of currently fielded systems. Recent advances in solid propellants has made the management of muzzle signature (flash) a principle issue in weapons development across the calibers. A priori prediction of the electromagnetic spectra of formulations will allow researchers to tailor blends that yield desired signatures and determine spectrographic detection ranges. We are currently employing quantum chemistry methods at various levels of sophistication to optimize molecular geometries, compute vibrational frequencies, and determine the optical spectra of specific gas-phase molecules and radicals of interest. Electronic excitations are being computed using Time Dependent Density Functional Theory (TD-DFT). A comparison of computational results to experimental values found in the literature is used to assess the affect of basis set and functional choice on calculation accuracy. The current status of this work will be presented at the conference. Work supported by the ARL, and USMA.

High current density 2D/3D MoS2/GaN Esaki tunnel diodes

NASA Astrophysics Data System (ADS)

Krishnamoorthy, Sriram; Lee, Edwin W.; Lee, Choong Hee; Zhang, Yuewei; McCulloch, William D.; Johnson, Jared M.; Hwang, Jinwoo; Wu, Yiying; Rajan, Siddharth

2016-10-01

The integration of two-dimensional materials such as transition metal dichalcogenides with bulk semiconductors offer interesting opportunities for 2D/3D heterojunction-based device structures without any constraints of lattice matching. By exploiting the favorable band alignment at the GaN/MoS2 heterojunction, an Esaki interband tunnel diode is demonstrated by transferring large area Nb-doped, p-type MoS2 onto heavily n-doped GaN. A peak current density of 446 A/cm2 with repeatable room temperature negative differential resistance, peak to valley current ratio of 1.2, and minimal hysteresis was measured in the MoS2/GaN non-epitaxial tunnel diode. A high current density of 1 kA/cm2 was measured in the Zener mode (reverse bias) at -1 V bias. The GaN/MoS2 tunnel junction was also modeled by treating MoS2 as a bulk semiconductor, and the electrostatics at the 2D/3D interface was found to be crucial in explaining the experimentally observed device characteristics.

A curricular frame for physics education: Development, comparison with students' interests, and impact on students' achievement and self-concept

NASA Astrophysics Data System (ADS)

Häussler, Peter; Hoffmann, Lore

2000-11-01

This article presents three interlinked studies aimed at: (1) developing a curricular frame for physics education; (2) assessing the students' interest in the contents, contexts, and activities that are suggested by that curricular frame; and (3) developing a curriculum that is in line with that frame and measuring its cognitive and emotional effects on students. The curricular frame was developed by adopting the Delphi technique and drawing on the expertise of 73 persons selected according to specified selection criteria. Interest data of some 8000 students and information of the presently taught physics curriculum were sampled longitudinally as well as cross-sectionally in various German Länder (states) by questionnaire. The third study comprised 23 experimental and 7 control classes. As a result of the comparison between the features of the curricular frame, the interest structure of students, and the current physics curriculum, there is a remarkable congruency between students' interest in physics and the kind of physics education identified in the Delphi study as being relevant. However, there is a considerable discrepancy between students' interest and the kind of physics instruction practiced in the physics classroom. Regression analysis revealed that students' interest in physics as a school subject is hardly related to their interest in physics, but mainly to the students' self-esteem of being good achievers. The data strongly suggest physics be taught so that students have a chance to develop a positive physics-related self-concept and to link physics with situations they encounter outside the classroom. A curriculum based on these principles proved superior compared to a traditional curriculum.

Nanomaterial datasets to advance tomography in scanning transmission electron microscopy

DOE PAGES

Levin, Barnaby D. A.; Padgett, Elliot; Chen, Chien-Chun; ...

2016-06-07

Electron tomography in materials science has flourished with the demand to characterize nanoscale materials in three dimensions (3D). Access to experimental data is vital for developing and validating reconstruction methods that improve resolution and reduce radiation dose requirements. This work presents five high-quality scanning transmission electron microscope (STEM) tomography datasets in order to address the critical need for open access data in this field. The datasets represent the current limits of experimental technique, are of high quality, and contain materials with structural complexity. Included are tomographic series of a hyperbranched Co 2 P nanocrystal, platinum nanoparticles on a carbonmore » nanofibre imaged over the complete 180° tilt range, a platinum nanoparticle and a tungsten needle both imaged at atomic resolution by equal slope tomography, and a through-focal tilt series of PtCu nanoparticles. A volumetric reconstruction from every dataset is provided for comparison and development of post-processing and visualization techniques. Researchers interested in creating novel data processing and reconstruction algorithms will now have access to state of the art experimental test data.« less

Experimental apparatus for overlapping a ground-state cooled ion with ultracold atoms

NASA Astrophysics Data System (ADS)

Meir, Ziv; Sikorsky, Tomas; Ben-shlomi, Ruti; Akerman, Nitzan; Pinkas, Meirav; Dallal, Yehonatan; Ozeri, Roee

2018-03-01

Experimental realizations of charged ions and neutral atoms in overlapping traps are gaining increasing interest due to their wide research application ranging from chemistry at the quantum level to quantum simulations of solid state systems. In this paper, we describe our experimental system in which we overlap a single ground-state cooled ion trapped in a linear Paul trap with a cloud of ultracold atoms such that both constituents are in the ?K regime. Excess micromotion (EMM) currently limits atom-ion interaction energy to the mK energy scale and above. We demonstrate spectroscopy methods and compensation techniques which characterize and reduce the ion's parasitic EMM energy to the ?K regime even for ion crystals of several ions. We further give a substantial review on the non-equilibrium dynamics which governs atom-ion systems. The non-equilibrium dynamics is manifested by a power law distribution of the ion's energy. We also give an overview on the coherent and non-coherent thermometry tools which can be used to characterize the ion's energy distribution after single to many atom-ion collisions.

Nanomaterial datasets to advance tomography in scanning transmission electron microscopy.

PubMed

Levin, Barnaby D A; Padgett, Elliot; Chen, Chien-Chun; Scott, M C; Xu, Rui; Theis, Wolfgang; Jiang, Yi; Yang, Yongsoo; Ophus, Colin; Zhang, Haitao; Ha, Don-Hyung; Wang, Deli; Yu, Yingchao; Abruña, Hector D; Robinson, Richard D; Ercius, Peter; Kourkoutis, Lena F; Miao, Jianwei; Muller, David A; Hovden, Robert

2016-06-07

Electron tomography in materials science has flourished with the demand to characterize nanoscale materials in three dimensions (3D). Access to experimental data is vital for developing and validating reconstruction methods that improve resolution and reduce radiation dose requirements. This work presents five high-quality scanning transmission electron microscope (STEM) tomography datasets in order to address the critical need for open access data in this field. The datasets represent the current limits of experimental technique, are of high quality, and contain materials with structural complexity. Included are tomographic series of a hyperbranched Co2P nanocrystal, platinum nanoparticles on a carbon nanofibre imaged over the complete 180° tilt range, a platinum nanoparticle and a tungsten needle both imaged at atomic resolution by equal slope tomography, and a through-focal tilt series of PtCu nanoparticles. A volumetric reconstruction from every dataset is provided for comparison and development of post-processing and visualization techniques. Researchers interested in creating novel data processing and reconstruction algorithms will now have access to state of the art experimental test data.

Nanomaterial datasets to advance tomography in scanning transmission electron microscopy

PubMed Central

Levin, Barnaby D.A.; Padgett, Elliot; Chen, Chien-Chun; Scott, M.C.; Xu, Rui; Theis, Wolfgang; Jiang, Yi; Yang, Yongsoo; Ophus, Colin; Zhang, Haitao; Ha, Don-Hyung; Wang, Deli; Yu, Yingchao; Abruña, Hector D.; Robinson, Richard D.; Ercius, Peter; Kourkoutis, Lena F.; Miao, Jianwei; Muller, David A.; Hovden, Robert

2016-01-01

Electron tomography in materials science has flourished with the demand to characterize nanoscale materials in three dimensions (3D). Access to experimental data is vital for developing and validating reconstruction methods that improve resolution and reduce radiation dose requirements. This work presents five high-quality scanning transmission electron microscope (STEM) tomography datasets in order to address the critical need for open access data in this field. The datasets represent the current limits of experimental technique, are of high quality, and contain materials with structural complexity. Included are tomographic series of a hyperbranched Co2P nanocrystal, platinum nanoparticles on a carbon nanofibre imaged over the complete 180° tilt range, a platinum nanoparticle and a tungsten needle both imaged at atomic resolution by equal slope tomography, and a through-focal tilt series of PtCu nanoparticles. A volumetric reconstruction from every dataset is provided for comparison and development of post-processing and visualization techniques. Researchers interested in creating novel data processing and reconstruction algorithms will now have access to state of the art experimental test data. PMID:27272459

Imagine-Self Perspective-Taking and Rational Self-Interested Behavior in a Simple Experimental Normal-Form Game.

PubMed

Karbowski, Adam; Ramsza, Michał

2017-01-01

The purpose of this study is to explore the link between imagine-self perspective-taking and rational self-interested behavior in experimental normal-form games. Drawing on the concept of sympathy developed by Adam Smith and further literature on perspective-taking in games, we hypothesize that introduction of imagine-self perspective-taking by decision-makers promotes rational self-interested behavior in a simple experimental normal-form game. In our study, we examined behavior of 404 undergraduate students in the two-person game, in which the participant can suffer a monetary loss only if she plays her Nash equilibrium strategy and the opponent plays her dominated strategy. Results suggest that the threat of suffering monetary losses effectively discourages the participants from choosing Nash equilibrium strategy. In general, players may take into account that opponents choose dominated strategies due to specific not self-interested motivations or errors. However, adopting imagine-self perspective by the participants leads to more Nash equilibrium choices, perhaps by alleviating participants' attributions of susceptibility to errors or non-self-interested motivation to the opponents.

Imagine-Self Perspective-Taking and Rational Self-Interested Behavior in a Simple Experimental Normal-Form Game

PubMed Central

Karbowski, Adam; Ramsza, Michał

2017-01-01

The purpose of this study is to explore the link between imagine-self perspective-taking and rational self-interested behavior in experimental normal-form games. Drawing on the concept of sympathy developed by Adam Smith and further literature on perspective-taking in games, we hypothesize that introduction of imagine-self perspective-taking by decision-makers promotes rational self-interested behavior in a simple experimental normal-form game. In our study, we examined behavior of 404 undergraduate students in the two-person game, in which the participant can suffer a monetary loss only if she plays her Nash equilibrium strategy and the opponent plays her dominated strategy. Results suggest that the threat of suffering monetary losses effectively discourages the participants from choosing Nash equilibrium strategy. In general, players may take into account that opponents choose dominated strategies due to specific not self-interested motivations or errors. However, adopting imagine-self perspective by the participants leads to more Nash equilibrium choices, perhaps by alleviating participants’ attributions of susceptibility to errors or non-self-interested motivation to the opponents. PMID:28955276

Electron transport in molecular wires with transition metal contacts

NASA Astrophysics Data System (ADS)

Dalgleish, Hugh

A molecular wire is an organic molecule that forms a conducting bridge between electronic contacts. Single molecules are likely to be the smallest entities to conduct electricity and thus molecular wires present many interesting challenges to fundamental science as well as enormous potential for nanoelectronic technological applications. A particular challenge stems from the realization that the properties of molecular wires are strongly influenced by the combined characteristics of the molecule and the metal contacts. While gold has been the most studied contact material to date, interest in molecular wires with transition metal contacts that are electronically more complex than gold is growing. This thesis presents a theoretical investigation of electron transport and associated phenomena in molecular wires with transition metal contacts. An appropriate methodology is developed on the basis of Landauer theory and ab initio and semi-empirical considerations and new, physically important systems are identified. Spin-dependent transport mechanisms and device characteristics are explored for molecular wires with ferromagnetic iron contacts, systems that have not been considered previously, either theoretically or experimentally. Electron transport between iron point contacts bridged by iron atoms is also investigated. Spin-dependent transport is also studied for molecules bridging nickel contacts and a possible explanation of some experimentally observed phenomena is proposed. A novel physical phenomenon termed strong spin current rectification and a new controllable negative differential resistance mechanism with potential applications for molecular electronic technology are introduced. The phenomena predicted in this thesis should be accessible to present day experimental techniques and this work is intended to stimulate experiments directed at observing them. Keywords. molecular electronics; spintronics; electron transport; interface states.

Going "social" to access experimental and potentially life-saving treatment: an assessment of the policy and online patient advocacy environment for expanded access.

PubMed

Mackey, Tim K; Schoenfeld, Virginia J

2016-02-02

Social media is fundamentally altering how we access health information and make decisions about medical treatment, including for terminally ill patients. This specifically includes the growing phenomenon of patients who use online petitions and social media campaigns in an attempt to gain access to experimental drugs through expanded access pathways. Importantly, controversy surrounding expanded access and "compassionate use" involves several disparate stakeholders, including patients, manufacturers, policymakers, and regulatory agencies-all with competing interests and priorities, leading to confusion, frustration, and ultimately advocacy. In order to explore this issue in detail, this correspondence article first conducts a literature review to describe how the expanded access policy and regulatory environment in the United States has evolved over time and how it currently impacts access to experimental drugs. We then conducted structured web searches to identify patient use of online petitions and social media campaigns aimed at compelling access to experimental drugs. This was carried out in order to characterize the types of communication strategies utilized, the diseases and drugs subject to expanded access petitions, and the prevalent themes associated with this form of "digital" patient advocacy. We find that patients and their families experience mixed results, but still gravitate towards the use of online campaigns out of desperation, lack of reliable information about treatment access options, and in direct response to limitations of the current fragmented structure of expanded access regulation and policy currently in place. In response, we discuss potential policy reforms to improve expanded access processes, including advocating greater transparency for expanded access programs, exploring use of targeted economic incentives for manufacturers, and developing systems to facilitate patient information about existing treatment options. This includes leveraging recent legislative attention to reform expanded access through the CURE Act Provisions contained in the proposed U.S. 21st Century Cures Act. While expanded access may not be the best option for the majority of individuals, terminally ill patients and their families nevertheless deserve better processes, policies, and availability to potentially life-changing information, before they decide to pursue an online campaign in the desperate hope of gaining access to experimental drugs.

Multilayer integral method for simulation of eddy currents in thin volumes of arbitrary geometry produced by MRI gradient coils.

PubMed

Sanchez Lopez, Hector; Freschi, Fabio; Trakic, Adnan; Smith, Elliot; Herbert, Jeremy; Fuentes, Miguel; Wilson, Stephen; Liu, Limei; Repetto, Maurizio; Crozier, Stuart

2014-05-01

This article aims to present a fast, efficient and accurate multi-layer integral method (MIM) for the evaluation of complex spatiotemporal eddy currents in nonmagnetic and thin volumes of irregular geometries induced by arbitrary arrangements of gradient coils. The volume of interest is divided into a number of layers, wherein the thickness of each layer is assumed to be smaller than the skin depth and where one of the linear dimensions is much smaller than the remaining two dimensions. The diffusion equation of the current density is solved both in time-harmonic and transient domain. The experimentally measured magnetic fields produced by the coil and the induced eddy currents as well as the corresponding time-decay constants were in close agreement with the results produced by the MIM. Relevant parameters such as power loss and force induced by the eddy currents in a split cryostat were simulated using the MIM. The proposed method is capable of accurately simulating the current diffusion process inside thin volumes, such as the magnet cryostat. The method permits the priori-calculation of optimal pre-emphasis parameters. The MIM enables unified designs of gradient coil-magnet structures for an optimal mitigation of deleterious eddy current effects. Copyright © 2013 Wiley Periodicals, Inc.

Megawatt Electromagnetic Plasma Propulsion

NASA Technical Reports Server (NTRS)

Gilland, James; Lapointe, Michael; Mikellides, Pavlos

2003-01-01

The NASA Glenn Research Center program in megawatt level electric propulsion is centered on electromagnetic acceleration of quasi-neutral plasmas. Specific concepts currently being examined are the Magnetoplasmadynamic (MPD) thruster and the Pulsed Inductive Thruster (PIT). In the case of the MPD thruster, a multifaceted approach of experiments, computational modeling, and systems-level models of self field MPD thrusters is underway. The MPD thruster experimental research consists of a 1-10 MWe, 2 ms pulse-forming-network, a vacuum chamber with two 32 diffusion pumps, and voltage, current, mass flow rate, and thrust stand diagnostics. Current focus is on obtaining repeatable thrust measurements of a Princeton Benchmark type self field thruster operating at 0.5-1 gls of argon. Operation with hydrogen is the ultimate goal to realize the increased efficiency anticipated using the lighter gas. Computational modeling is done using the MACH2 MHD code, which can include real gas effects for propellants of interest to MPD operation. The MACH2 code has been benchmarked against other MPD thruster data, and has been used to create a point design for a 3000 second specific impulse (Isp) MPD thruster. This design is awaiting testing in the experimental facility. For the PIT, a computational investigation using MACH2 has been initiated, with experiments awaiting further funding. Although the calculated results have been found to be sensitive to the initial ionization assumptions, recent results have agreed well with experimental data. Finally, a systems level self-field MPD thruster model has been developed that allows for a mission planner or system designer to input Isp and power level into the model equations and obtain values for efficiency, mass flow rate, and input current and voltage. This model emphasizes algebraic simplicity to allow its incorporation into larger trajectory or system optimization codes. The systems level approach will be extended to the pulsed inductive thruster and other electrodeless thrusters at a future date.

Centrifuge impact cratering experiments: Scaling laws for non-porous targets

NASA Technical Reports Server (NTRS)

Schmidt, Robert M.

1987-01-01

This research is a continuation of an ongoing program whose objective is to perform experiments and to develop scaling relationships for large body impacts onto planetary surfaces. The development of the centrifuge technique has been pioneered by the present investigator and is used to provide experimental data for actual target materials of interest. With both powder and gas guns mounted on a rotor arm, it is possible to match various dimensionless similarity parameters, which have been shown to govern the behavior of large scale impacts. Current work is directed toward the determination of scaling estimates for nonporous targets. The results are presented in summary form.

Physics through the 1990s: Condensed-matter physics

NASA Technical Reports Server (NTRS)

1986-01-01

The volume presents the current status of condensed-matter physics from developments since the 1970s to opportunities in the 1990s. Topics include electronic structure, vibrational properties, critical phenomena and phase transitions, magnetism, semiconductors, defects and diffusion, surfaces and interfaces, low-temperature physics, liquid-state physics, polymers, nonlinear dynamics, instabilities, and chaos. Appendices cover the connections between condensed-matter physics and applications of national interest, new experimental techniques and materials, laser spectroscopy, and national facilities for condensed-matter physics research. The needs of the research community regarding support for individual researchers and for national facilities are presented, as are recommendations for improved government-academic-industrial relations.

The history of neurosurgical treatment of sports concussion.

PubMed

Stone, James L; Patel, Vimal; Bailes, Julian E

2014-10-01

Concussion has a long and interesting history spanning at least the 5 millennia of written medical record and closely mirrors the development of surgery and neurosurgery. Not surprisingly, much of the past and present experimental head injury and concussion work has been performed within neurosurgically driven laboratories or by several surgically oriented neurologists. This historical review chronicles the key aspects of neurosurgical involvement in sports concussion as related to the diagnosis, treatment, mitigation, and prevention of injury using the example of American football. In addition, we briefly trace the developments that led to our current understanding of the biomechanical and neurophysiological basis of concussion.

Remote Sensing Studies Of The Current Martian Climate

NASA Astrophysics Data System (ADS)

Taylor, F. W.; McCleese, D. J.; Schofield, J. T.; Calcutt, S. B.; Moroz, V. I.

A systematic and detailed experimental study of the Martian atmosphere remains to be carried out, despite many decades of intense interest in the nature of the Martian climate system, its interactions, variability and long-term stability. Such a study is planned by the 2005 Mars Reconnaissance Orbiter, using limb-scanning infrared radiometric techniques similar to those used to study trace species in the terrestrial stratosphere. For Mars, the objectives are temperature, humidity, dust and condensate abundances with high vertical resolution and global coverage in the 0 to 80 km height range. The paper will discuss the experiment and its methodology and expectations for the results.

Diffusion of cesium and iodine in compressed IG-110 graphite compacts

NASA Astrophysics Data System (ADS)

Carter, L. M.; Brockman, J. D.; Robertson, J. D.; Loyalka, S. K.

2016-08-01

Nuclear graphite grade IG-110 is currently used in the High Temperature Engineering Test Reactor (HTTR) in Japan for certain permanent and replaceable core components, and is a material of interest in general. Therefore, transport parameters for fission products in this material are needed. Measurement of diffusion through pressed compacts of IG-110 graphite is experimentally attractive because they are easy to prepare with homogeneous distributions of fission product surrogates. In this work, we measured diffusion coefficients for Cs and I in pressed compacts made from IG-110 powder in the 1079-1290 K temperature range, and compared them to those obtained in as-received IG-110.

Initiation with an electron beam of chemical reactions of interest for visible wavelength lasers

NASA Technical Reports Server (NTRS)

Whittier, J. S.; Cool, T. A.

1976-01-01

A description is given of the first results obtained with a new shock tube-electron beam facility designed to provide a versatile means for the systematic search for laser operation among several candidate metal atom-oxidizer systems. According to the current experimental approach, metal atoms are obtained in the vapor phase by the dissociation of metal compounds. A shock tube is employed to provide a short duration flow through an array of 29 supersonic flow-mixing nozzles. A high energy electron accelerator is used for the rapid initiation of chemical reaction in a mixed flow of encapsulated metal and oxidizer.

Estimation of 99Mo production rates from natural molybdenum in research reactors.

PubMed

Blaauw, M; Ridikas, D; Baytelesov, S; Salas, P S Bedregal; Chakrova, Y; Eun-Ha, Cho; Dahalan, R; Fortunato, A H; Jacimovic, R; Kling, A; Muñoz, L; Mohamed, N M A; Párkányi, D; Singh, T; Van Dong Duong

2017-01-01

Molybdenum-99 is one of the most important radionuclides for medical diagnostics. In 2015, the International Atomic Energy Agency organized a round-robin exercise where the participants measured and calculated specific saturation activities achievable for the 98 Mo(n,γ) 99 Mo reaction. This reaction is of interest as a means to locally, and on a small scale, produce 99 Mo from natural molybdenum. The current paper summarises a set of experimental results and reviews the methodology for calculating the corresponding saturation activities. Activation by epithermal neutrons and also epithermal neutron self-shielding are found to be of high importance in this case.

Preliminary investigation on the use of low current pulsed power Z-pinch plasma devices for the study of early stage plasma instabilities

NASA Astrophysics Data System (ADS)

Kaselouris, E.; Dimitriou, V.; Fitilis, I.; Skoulakis, A.; Koundourakis, G.; Clark, E. L.; Chatzakis, J.; Bakarezos, Μ; Nikolos, I. K.; Papadogiannis, N. A.; Tatarakis, M.

2018-01-01

This article addresses key features for the implementation of low current pulsed power plasma devices for the study of matter dynamics from the solid to the plasma phase. The renewed interest in such low current plasma devices lies in the need to investigate methods for the mitigation of prompt seeding mechanisms for the generation of plasma instabilities. The low current when driven into thick wires (skin effect mode) allows for the simultaneous existence of all phases of matter from solid to plasma. Such studies are important for the concept of inertial confinement fusion where the mitigation of the instability seeding mechanisms arising from the very early moments within the target’s heating is of crucial importance. Similarly, in the magnetized liner inertial fusion concept it is an open question as to how much surface non-uniformity correlates with the magneto-Rayleigh-Taylor instability, which develops during the implosion. This study presents experimental and simulation results, which demonstrate that the use of low current pulsed power devices in conjunction with appropriate diagnostics can be important for studying seeding mechanisms for the imminent generation of plasma instabilities in future research.

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies.

PubMed

Davis, Esther F; Newton, Laura; Lewandowski, Adam J; Lazdam, Merzaka; Kelly, Brenda A; Kyriakou, Theodosios; Leeson, Paul

2012-07-01

Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2-5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu.

The ART of marketing babies.

PubMed

Qadeer, Imrana

2010-01-01

New legislation can be oppressive for a significant population depending upon the politics of its drafters. The current upsurge of the surrogacy trade in India, and the label of a "win-win" situation that it has acquired, points towards an unfettered commercialisation of assisted reproductive technology and the practice of surrogacy that is blinding its middle class users as well as providers, policy makers and law makers, and charging an imagination that is already caught up in spiralling consumerism. This paper analyses the Draft Assisted Reproductive Technology (Regulation) Bill and Rules, 2008, in the Indian socioeconomic context. It identifies the interests of the affected women, and examines the contradictions of the proposed Bill with their interests, as well as with current health and population policies, confining itself to the handling of surrogacy and not the entire content of the Bill. The bases of the analytical perspective used are: the context of poverty and the health needs of the Indian population; the need to locate surrogacy services within the overall public health service context and its epidemiological basis; the need to restrain direct human experimentation for the advancement of any technology; the use of safer methods; and, finally, the rights of surrogate mothers and their babies, in India, as opposed to the compulsion or dynamics of the medical market and reproductive tourism.

Analysis of discriminants for experimental 3D SAR imagery of human targets

NASA Astrophysics Data System (ADS)

Chan, Brigitte; Sévigny, Pascale; DiFilippo, David D. J.

2014-10-01

Development of a prototype 3-D through-wall synthetic aperture radar (SAR) system is currently underway at Defence Research and Development Canada. The intent is to map out building wall layouts and to detect targets of interest and their location behind walls such as humans, arms caches, and furniture. This situational awareness capability can be invaluable to the military working in an urban environment. Tools and algorithms are being developed to exploit the resulting 3-D imagery. Current work involves analyzing signatures of targets behind a wall and understanding the clutter and multipath signals in a room of interest. In this paper, a comprehensive study of 3-D human target signature metrics in free space is presented. The aim is to identify features for discrimination of the human target from other targets. Targets used in this investigation include a human standing, a human standing with arms stretched out, a chair, a table, and a metallic plate. Several features were investigated as potential discriminants and five which were identified as good candidates are presented in this paper. Based on this study, no single feature could be used to fully discriminate the human targets from all others. A combination of at least two different features is required to achieve this.

Liquid droplet radiator development status

NASA Technical Reports Server (NTRS)

White, K. Alan, III

1987-01-01

Development of the Liquid Droplet Radiator (LDR) is described. Significant published results of previous investigators are presented, and work currently in progress is discussed. Several proposed LDR configurations are described, and the rectangular and triangular configurations currently of most interest are examined. Development of the droplet generator, collector, and auxiliary components are discussed. Radiative performance of a droplet sheet is considered, and experimental results are seen to be in very good agreement with analytical predictions. The collision of droplets in the droplet sheet, the charging of droplets by the space plasma, and the effect of atmospheric drag on the droplet sheet are shown to be of little consequence, or can be minimized by proper design. The LDR is seen to be less susceptible than conventional technology to the effects of micrometeoroids or hostile threats. The identification of working fluids which are stable in the orbital environments of interest is also made. Methods for reducing spacecraft contamination from an LDR to an acceptable level are discussed. Preliminary results of microgravity testing of the droplet generator are presented. Possible future NASA and Air Force missions enhanced or enabled by a LDR are also discussed. System studies indicate that the LDR is potentially less massive than heat pipe radiators. Planned microgravity testing aboard the Shuttle or space station is seen to be a logical next step in LDR development.

Detection and interrogation of biomolecules via nanoscale probes: From fundamental physics to DNA sequencing

NASA Astrophysics Data System (ADS)

Zwolak, Michael

2013-03-01

A rapid and low-cost method to sequence DNA would revolutionize personalized medicine, where genetic information is used to diagnose, treat, and prevent diseases. There is a longstanding interest in nanopores as a platform for rapid interrogation of single DNA molecules. I will discuss a sequencing protocol based on the measurement of transverse electronic currents during the translocation of single-stranded DNA through nanopores. Using molecular dynamics simulations coupled to quantum mechanical calculations of the tunneling current, I will show that the DNA nucleotides are predicted to have distinguishable electronic signatures in experimentally realizable systems. Several recent experiments support our theoretical predictions. In addition to their possible impact in medicine and biology, the above methods offer ideal test beds to study open scientific issues in the relatively unexplored area at the interface between solids, liquids, and biomolecules at the nanometer length scale. http://mike.zwolak.org

Review of current interest and research in water hyacinth-based wastewater treatment

NASA Technical Reports Server (NTRS)

Markarian, R. K.; Balon, J. E.; Robinson, A. C.

1977-01-01

The status of activity in the user community for water hyacinth-based wastewater treatment was evaluated. The principal technique used was that of interviewing people who either (1) were known to be engaged in hyacinth research or development or (2) had made inquiry to NASA about hyacinth systems. About 40 non-research organizations and a similar number of research organizations were contacted. As a result of the interviews and a review of the relevant literature, it was concluded that hyacinth systems have the potential for providing a lower cost way for small cities to meet increasingly stringent effluent requirements. A limited amount of full-scale demonstration of hyacinth systems has been carried out during the past two years, but the yield of design data has been small. Several organizations are currently planning construction of experimental full-scale hyacinth-based wastewater treatment systems during 1977-1978.

A comparison of lightning and nuclear electromagnetic pulse response of tactical shelters

NASA Technical Reports Server (NTRS)

Perala, R. A.; Rudolph, T. H.; Mckenna, P. M.

1984-01-01

The internal response (electromagnetic fields and cable responses) of tactical shelters is addressed. Tactical shelters are usually well-shielded systems. Apart from penetrations by signal and power lines, the main leakage paths to the interior are via seams and the environment control unit (ECU) honeycomb filter. The time domain in three-dimensional finite-difference technique is employed to determine the external and internal coupling to a shelter excited by nuclear electromagnetic pulses (NEMP) and attached lightning. The responses of interest are the internal electromagnetic fields and the voltage, current, power, and energy coupled to internal cables. Leakage through the seams and ECU filter is accomplished by their transfer impedances which relate internal electric fields to external current densities. Transfer impedances which were experimentally measured are used in the analysis. The internal numerical results are favorably compared to actual shelter test data under simulated NEMP illumination.

Large-signal model of the bilayer graphene field-effect transistor targeting radio-frequency applications: Theory versus experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasadas, Francisco, E-mail: Francisco.Pasadas@uab.cat; Jiménez, David

2015-12-28

Bilayer graphene is a promising material for radio-frequency transistors because its energy gap might result in a better current saturation than the monolayer graphene. Because the great deal of interest in this technology, especially for flexible radio-frequency applications, gaining control of it requires the formulation of appropriate models for the drain current, charge, and capacitance. In this work, we have developed them for a dual-gated bilayer graphene field-effect transistor. A drift-diffusion mechanism for the carrier transport has been considered coupled with an appropriate field-effect model taking into account the electronic properties of the bilayer graphene. Extrinsic resistances have been includedmore » considering the formation of a Schottky barrier at the metal-bilayer graphene interface. The proposed model has been benchmarked against experimental prototype transistors, discussing the main figures of merit targeting radio-frequency applications.« less

Torque ripple reduction of brushless DC motor based on adaptive input-output feedback linearization.

PubMed

Shirvani Boroujeni, M; Markadeh, G R Arab; Soltani, J

2017-09-01

Torque ripple reduction of Brushless DC Motors (BLDCs) is an interesting subject in variable speed AC drives. In this paper at first, a mathematical expression for torque ripple harmonics is obtained. Then for a non-ideal BLDC motor with known harmonic contents of back-EMF, calculation of desired reference current amplitudes, which are required to eliminate some selected harmonics of torque ripple, are reviewed. In order to inject the reference harmonic currents to the motor windings, an Adaptive Input-Output Feedback Linearization (AIOFBL) control is proposed, which generates the reference voltages for three phases voltage source inverter in stationary reference frame. Experimental results are presented to show the capability and validity of the proposed control method and are compared with the vector control in Multi-Reference Frame (MRF) and Pseudo-Vector Control (P-VC) method results. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Negative differential resistance and magnetoresistance in zigzag borophene nanoribbons

NASA Astrophysics Data System (ADS)

Liu, Jiayi; Wu, Jiaxin; Chen, Changpeng; Han, Lu; Zhu, Ziqing; Wu, Jinping

2018-02-01

Since borophene has been grown experimentally, its extraordinary characteristics have attracted more and more attentions. In this paper, we construct pristine zigzag-edged borophene nanoribbons (ZBNRs) of different widths to study the transport properties, using the first-principles calculations. The differences of the quantum transport properties are discussed, where even-N ZBNRs and odd-N ZBNRs have different current-voltage relationships. Especially, the negative differential resistance (NDR) can be observed within certain bias range in 5-ZBNR and 7-ZBNR, while 6-ZBNR behaves like a metal whose current rises with the increase of the voltage. Moreover, borophene nanoribbon shows interesting magnetic transport properties. The spin-filtering effect can be revealed when the two electrodes have opposite magnetization directions. Besides, the magnetoresistance effect appears to exist in even-N ZBNRs and the maximum value can reach 70%. The mechanisms of these phenomena are proposed in detail.

Is news media related to civic engagement? The effects of interest in and discussions about the news media on current and future civic engagement of adolescents.

PubMed

Erentaitė, Rasa; Žukauskienė, Rita; Beyers, Wim; Pilkauskaitė-Valickienė, Rasa

2012-06-01

This study explored whether discussions about the media, when positively linked to interest in the news media, were related to adolescents' current and future civic engagement. A sample of 2638 adolescents (age M = 17, SD = 1.2), who participated in a school-based study on positive socialization, completed self-report measures on interest in the news media and discussions about the media with parents and friends. Current civic engagement was measured by involvement in volunteering and civic commitments. Future civic engagement was measured by intentions to participate in civic activities in the future. The results showed that more interpersonal discussions about the media and higher interest in the news media both predicted higher civic engagement. Positive links between discussions about the media and current civic engagement were partly mediated by interest in the news media. In addition, interest in the news media together with current civic engagement fully mediated a positive link between discussions about the media and future civic engagement. Moderating effects of gender were observed, with discussions about the media a better predictor of boys' interest in the news media, and current civic engagement a better predictor of girls' future civic engagement. Copyright © 2011 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Self-Efficacy and Interest: Experimental Studies of Optimal Incompetence.

ERIC Educational Resources Information Center

Silvia, Paul J.

2003-01-01

To test the optimal incompetence hypothesis (high self-efficacy lowers task interest), 30 subjects rated interest, perceived difficulty, and confidence of success in different tasks. In study 2, 33 subjects completed a dart-game task in easy, moderate, and difficult conditions. In both, interest was a quadratic function of self-efficacy,…

Measuring mRNA copy-number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization (smFISH)

PubMed Central

Skinner, Samuel O.; Sepúlveda, Leonardo A.; Xu, Heng; Golding, Ido

2014-01-01

We present a method for measuring the absolute number of mRNA molecules from a gene of interest in individual, chemically fixed Escherichia coli cells. A set of fluorescently-labeled oligonucleotide probes are hybridized to the target mRNA, so that each mRNA molecule is decorated by a known number of fluorescent dyes. Cells are then imaged using fluorescence microscopy. The number of target mRNA is estimated from the total intensity of fluorescent foci in the cell, rather than from counting discrete “spots” as in other currently available protocols. Image analysis is performed using an automated algorithm. The measured mRNA copy-number distribution obtained from many individual cells can be used to extract the parameters of stochastic gene activity, namely the frequency and size of transcription bursts from the gene of interest. The experimental procedure takes 2 days, with another 2-3 days typically required for image and data analysis. PMID:23680982

Tunable electronic and magnetic properties of two‐dimensional materials and their one‐dimensional derivatives

PubMed Central

Zhang, Zhuhua; Liu, Xiaofei; Yu, Jin; Hang, Yang; Li, Yao; Guo, Yufeng; Xu, Ying; Sun, Xu; Zhou, Jianxin

2016-01-01

Low‐dimensional materials exhibit many exceptional properties and functionalities which can be efficiently tuned by externally applied force or fields. Here we review the current status of research on tuning the electronic and magnetic properties of low‐dimensional carbon, boron nitride, metal‐dichalcogenides, phosphorene nanomaterials by applied engineering strain, external electric field and interaction with substrates, etc, with particular focus on the progress of computational methods and studies. We highlight the similarities and differences of the property modulation among one‐ and two‐dimensional nanomaterials. Recent breakthroughs in experimental demonstration of the tunable functionalities in typical nanostructures are also presented. Finally, prospective and challenges for applying the tunable properties into functional devices are discussed. WIREs Comput Mol Sci 2016, 6:324–350. doi: 10.1002/wcms.1251 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article. PMID:27818710

Simulating demand for cigarettes among pregnant women: A Low-Risk method for studying vulnerable populations.

PubMed

Higgins, Stephen T; Reed, Derek D; Redner, Ryan; Skelly, Joan M; Zvorsky, Ivori A; Kurti, Allison N

2017-01-01

A substantive obstacle to experimentally studying cigarette smoking and use of other tobacco products in pregnant women is the risk of adverse effects on mother and fetus from experimenter administration of the product of interest. The purpose of this study is to investigate bypassing that obstacle by using behavioral economic simulation tasks. In the present study we used the Cigarette Purchase Task (CPT) to simulate changes in demand for hypothetical cigarettes as a function of varying cigarette prices. Participants were 95 pregnant women who completed the CPT prior to participation in a smoking-cessation trial. Aggregate and individual participant demand varied as an orderly function of price and those changes were well fitted by an exponential equation. Demand also varied in correspondence to two well-validated predictors of individual differences in smoking cessation among pregnant women (cigarettes smoked per day, pre-pregnancy quit attempts). Moreover, CPT indices were more effective than these two conventional variables in predicting individual differences in whether women made a quit attempt during the current pregnancy. Overall, these results represent a promising step in demonstrating the validity and utility of the CPT for experimentally examining demand for cigarettes, and potentially other tobacco and nicotine delivery products, among pregnant women. © 2016 Society for the Experimental Analysis of Behavior.

Experimental quantum simulations of many-body physics with trapped ions.

PubMed

Schneider, Ch; Porras, Diego; Schaetz, Tobias

2012-02-01

Direct experimental access to some of the most intriguing quantum phenomena is not granted due to the lack of precise control of the relevant parameters in their naturally intricate environment. Their simulation on conventional computers is impossible, since quantum behaviour arising with superposition states or entanglement is not efficiently translatable into the classical language. However, one could gain deeper insight into complex quantum dynamics by experimentally simulating the quantum behaviour of interest in another quantum system, where the relevant parameters and interactions can be controlled and robust effects detected sufficiently well. Systems of trapped ions provide unique control of both the internal (electronic) and external (motional) degrees of freedom. The mutual Coulomb interaction between the ions allows for large interaction strengths at comparatively large mutual ion distances enabling individual control and readout. Systems of trapped ions therefore exhibit a prominent system in several physical disciplines, for example, quantum information processing or metrology. Here, we will give an overview of different trapping techniques of ions as well as implementations for coherent manipulation of their quantum states and discuss the related theoretical basics. We then report on the experimental and theoretical progress in simulating quantum many-body physics with trapped ions and present current approaches for scaling up to more ions and more-dimensional systems.

Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design.

PubMed

Albanaz, Amanda T S; Rodrigues, Carlos H M; Pires, Douglas E V; Ascher, David B

2017-06-01

Mutations introduce diversity into genomes, leading to selective changes and driving evolution. These changes have contributed to the emergence of many of the current major health concerns of the 21st century, from the development of genetic diseases and cancers to the rise and spread of drug resistance. The experimental systematic testing of all mutations in a system of interest is impractical and not cost-effective, which has created interest in the development of computational tools to understand the molecular consequences of mutations to aid and guide rational experimentation. Areas covered: Here, the authors discuss the recent development of computational methods to understand the effects of coding mutations to protein function and interactions, particularly in the context of the 3D structure of the protein. Expert opinion: While significant progress has been made in terms of innovative tools to understand and quantify the different range of effects in which a mutation or a set of mutations can give rise to a phenotype, a great gap still exists when integrating these predictions and drawing causality conclusions linking variants. This often requires a detailed understanding of the system being perturbed. However, as part of the drug development process it can be used preemptively in a similar fashion to pharmacokinetics predictions, to guide development of therapeutics to help guide the design and analysis of clinical trials, patient treatment and public health policy strategies.

Cigarette Users’ Interest in Using or Switching to Electronic Nicotine Delivery Systems for Smokeless Tobacco for Harm Reduction, Cessation, or Novelty: A Cross-Sectional Survey of US Adults

PubMed Central

Haardoerfer, Regine; Escoffery, Cam; Zheng, Pinpin; Kegler, Michelle

2015-01-01

Introduction: We examined: (a) current (past 30-day) smokers’ interest in using or switching to electronic nicotine delivery systems (ENDS) or smokeless tobacco for various reasons; (b) correlates of interest in these products; and (c) subgroups of current smokers in relation to interest in these products. Methods: We conducted a cross-sectional survey assessing sociodemographics, tobacco use, interest in ENDS and smokeless tobacco among smokers, and knowledge about ENDS among 2,501US adults recruited through an online consumer panel. We oversampled tobacco users (36.7% current cigarette smokers), ethnic minorities, and southeastern US state residents. Results: On average, participants were more interested in ENDS than smokeless tobacco across all reasons provided. Additionally, they were less interested in either product because of their potential use in places prohibiting smoking or due to curiosity and more interested in reducing health risk or cigarette consumption or to aid in cessation. We documented high rates (27.9%) of misbeliefs about Food and Drug Administration approval of ENDS for cessation, particularly among current smokers (38.5%). Also, 27.2% of current smokers had talked with a health care provider about ENDS, with 18.0% reporting that their provider endorsed ENDS use for cessation. Furthermore, cluster analyses revealed 3 groups distinct in their interest in the products, sociodemographics, and smoking-related characteristics. Conclusions: This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical. PMID:24951496

Extraction of minority carrier diffusion length of MWIR Type-II superlattice nBp detector

NASA Astrophysics Data System (ADS)

Taghipour, Zahra; Kazemi, Alireza; Myers, Stephen; Wijewarnasuriya, Priyalal; Mathews, Sen; Steenbergen, Elizabeth H.; Morath, Christian; Cowan, Vincent M.; Ariyawansa, Gamini; Scheihing, John; Krishna, Sanjay

2017-08-01

We present a model for the spectral external quantum efficiency (EQE) to extract the minority carrier diffusion length (Ln) of a unipolar nBp InAs/GaSb Type-II superlattice (T2SL) mid-wave infrared (MWIR) detector. The detector consists of a 4 μm thick p-doped 10ML InAs/10ML GaSb SL absorber with a 50% cut-off wavelength of 5 μm at 80 K and zero bias. The n-type doped InAs/AlSb SL barrier in the structure was included to reduce the GR dark current. By fitting the experimentally measured EQE data to the theoretically calculated QE based on the solution of the drift-diffusion equation, the p-type absorber was found the have Ln = 10 +/- 0.5 μm at 80K, and Ln = 12 +/- 0.5 μm at 120K and 150K. We performed the absorption coefficient measurement at different temperatures of interest. Also, we estimated the reduced background concentration and the built-in potential by utilizing a capacitance-voltage measurement technique. We used time-resolved-photoluminescence (TRPL) to determine the lifetime at 80K. With the result of the model and the lifetime measurement, we calculated the diffusion coefficient and the mobility in the T2SL detector at various temperatures. Also, we studied the behavior of different dark current mechanisms by fitting the experimentally measured and simulated dark current density under different operating temperatures and biases.

Investigation of diocotron modes in toroidally trapped electron plasmas using non-destructive method

NASA Astrophysics Data System (ADS)

Lachhvani, Lavkesh; Pahari, Sambaran; Sengupta, Sudip; Yeole, Yogesh G.; Bajpai, Manu; Chattopadhyay, P. K.

2017-10-01

Experiments with trapped electron plasmas in a SMall Aspect Ratio Toroidal device (SMARTEX-C) have demonstrated a flute-like mode represented by oscillations on capacitive (wall) probes. Although analogous to diocotron mode observed in linear electron traps, the mode evolution in toroids can have interesting consequences due to the presence of in-homogeneous magnetic field. In SMARTEX-C, the probe signals are observed to undergo transition from small, near-sinusoidal oscillations to large amplitude, non-linear "double-peaked" oscillations. To interpret the wall probe signal and bring forth the dynamics, an expression for the induced current on the probe for an oscillating charge is derived, utilizing Green's Reciprocation Theorem. Equilibrium position, poloidal velocity of the charge cloud, and charge content of the cloud, required to compute the induced current, are estimated from the experiments. Signal through capacitive probes is thereby computed numerically for possible charge cloud trajectories. In order to correlate with experiments, starting with an intuitive guess of the trajectory, the model is evolved and tweaked to arrive at a signal consistent with experimentally observed probe signals. A possible vortex like dynamics is predicted, hitherto unexplored in toroidal geometries, for a limited set of experimental observations from SMARTEX-C. Though heuristic, a useful interpretation of capacitive probe data in terms of charge cloud dynamics is obtained.

Characterizing high-energy-density propellants for space propulsion applications

NASA Astrophysics Data System (ADS)

Kokan, Timothy

There exists wide ranging research interest in high-energy-density matter (HEDM) propellants as a potential replacement for existing industry standard fuels for liquid rocket engines. The U.S. Air Force Research Laboratory, the U.S. Army Research Lab, the NASA Marshall Space Flight Center, and the NASA Glenn Research Center each either recently concluded or currently has ongoing programs in the synthesis and development of these potential new propellants. In order to perform conceptual designs using these new propellants, most conceptual rocket engine powerhead design tools (e.g. NPSS, ROCETS, and REDTOP-2) require several thermophysical properties of a given propellant over a wide range of temperature and pressure. These properties include enthalpy, entropy, density, viscosity, and thermal conductivity. Very little thermophysical property data exists for most of these potential new HEDM propellants. Experimental testing of these properties is both expensive and time consuming and is impractical in a conceptual vehicle design environment. A new technique for determining these thermophysical properties of potential new rocket engine propellants is presented. The technique uses a combination of three different computational methods to determine these properties. Quantum mechanics and molecular dynamics are used to model new propellants at a molecular level in order to calculate density, enthalpy, and entropy. Additivity methods are used to calculate the kinematic viscosity and thermal conductivity of new propellants. This new technique is validated via a series of verification experiments of HEDM compounds. Results are provided for two HEDM propellants: quadricyclane and 2-azido-N,N-dimethylethanamine (DMAZ). In each case, the new technique does a better job than the best current computational methods at accurately matching the experimental data of the HEDM compounds of interest. A case study is provided to help quantify the vehicle level impacts of using HEDM propellants. The case study consists of the National Aeronautics and Space Administration's (NASA) Exploration Systems Architecture Study (ESAS) Lunar Surface Access Module (LSAM). The results of this study show that the use of HEDM propellants instead of hypergolic propellants can lower the gross weight of the LSAM and may be an attractive alternative to the current baseline hypergolic propellant choice.

Effects of Participation in a Health Careers Orientation Program and Family Support for a Health Career Choice on Health Career Interests of Young People.

ERIC Educational Resources Information Center

Crawford, Charles O.

The effects of two factors which may influence the interests of young people in a health career are examined--family support and participation in a careers orientation program. An experimental group of 27 Grade 8 students was matched with a control group of 27 students according to parental education, color, and sex. The experimental group…

Innovative strategies for teaching nursing research in Taiwan.

PubMed

Liou, Shwu-Ru; Cheng, Ching-Yu; Tsai, Hsiu-Min; Chang, Chia-Hao

2013-01-01

Evidence-based practice is imperative in clinical settings because it bridges the gap between research findings and clinical practice. Promoting nursing student interest and enthusiasm for research is therefore crucial when teaching nursing research. The aim of thus study was to develop innovative teaching strategies that increase nursing students' interests and engagement in research. This study employed a descriptive, pretest-posttest, quasiexperimental design with 103 participants in the experimental group and 106 in the control group. The Attitudes toward Research Questionnaire, Classroom Engagement Scale, Self-Directed Learning Instrument, Nursing Eight Core Competencies Scale, Value of Teams survey, and a research knowledge test were applied to evaluate the outcomes of the innovative teaching strategies. Scores for the research knowledge test were significantly higher in the experimental group than in the control group in posttest 1 and posttest 2. After the intervention, participants in the experimental group exhibited higher scores on attitudes toward research, eight core competencies in nursing,value of teams, classroom engagement, and self-directed learning than participants in the control group. Students in the experimental group perceived a lower degree of pressure and higher degrees of interest, enjoyment, and acceptance of the research course than students in the control group. This study confirmed that using innovative teaching strategies in nursing research courses enhances student interest and enthusiasm about evidence-based practice.

Numerical simulation and experimental validation of Lamb wave propagation behavior in composite plates

NASA Astrophysics Data System (ADS)

Kim, Sungwon; Uprety, Bibhisha; Mathews, V. John; Adams, Daniel O.

2015-03-01

Structural Health Monitoring (SHM) based on Acoustic Emission (AE) is dependent on both the sensors to detect an impact event as well as an algorithm to determine the impact location. The propagation of Lamb waves produced by an impact event in thin composite structures is affected by several unique aspects including material anisotropy, ply orientations, and geometric discontinuities within the structure. The development of accurate numerical models of Lamb wave propagation has important benefits towards the development of AE-based SHM systems for impact location estimation. Currently, many impact location algorithms utilize the time of arrival or velocities of Lamb waves. Therefore the numerical prediction of characteristic wave velocities is of great interest. Additionally, the propagation of the initial symmetric (S0) and asymmetric (A0) wave modes is important, as these wave modes are used for time of arrival estimation. In this investigation, finite element analyses were performed to investigate aspects of Lamb wave propagation in composite plates with active signal excitation. A comparative evaluation of two three-dimensional modeling approaches was performed, with emphasis placed on the propagation and velocity of both the S0 and A0 wave modes. Results from numerical simulations are compared to experimental results obtained from active AE testing. Of particular interest is the directional dependence of Lamb waves in quasi-isotropic carbon/epoxy composite plates. Numerical and experimental results suggest that although a quasi-isotropic composite plate may have the same effective elastic modulus in all in-plane directions, the Lamb wave velocity may have some directional dependence. Further numerical analyses were performed to investigate Lamb wave propagation associated with circular cutouts in composite plates.

Magnetic field oscillations of the critical current in long ballistic graphene Josephson junctions

NASA Astrophysics Data System (ADS)

Rakyta, Péter; Kormányos, Andor; Cserti, József

2016-06-01

We study the Josephson current in long ballistic superconductor-monolayer graphene-superconductor junctions. As a first step, we have developed an efficient computational approach to calculate the Josephson current in tight-binding systems. This approach can be particularly useful in the long-junction limit, which has hitherto attracted less theoretical interest but has recently become experimentally relevant. We use this computational approach to study the dependence of the critical current on the junction geometry, doping level, and an applied perpendicular magnetic field B . In zero magnetic field we find a good qualitative agreement with the recent experiment of M. Ben Shalom et al. [Nat. Phys. 12, 318 (2016), 10.1038/nphys3592] for the length dependence of the critical current. For highly doped samples our numerical calculations show a broad agreement with the results of the quasiclassical formalism. In this case the critical current exhibits Fraunhofer-like oscillations as a function of B . However, for lower doping levels, where the cyclotron orbit becomes comparable to the characteristic geometrical length scales of the system, deviations from the results of the quasiclassical formalism appear. We argue that due to the exceptional tunability and long mean free path of graphene systems a new regime can be explored where geometrical and dynamical effects are equally important to understand the magnetic field dependence of the critical current.

Experimental Design of a Magnetic Flux Compression Experiment

NASA Astrophysics Data System (ADS)

Fuelling, Stephan; Awe, Thomas J.; Bauer, Bruno S.; Goodrich, Tasha; Lindemuth, Irvin R.; Makhin, Volodymyr; Siemon, Richard E.; Atchison, Walter L.; Reinovsky, Robert E.; Salazar, Mike A.; Scudder, David W.; Turchi, Peter J.; Degnan, James H.; Ruden, Edward L.

2007-06-01

Generation of ultrahigh magnetic fields is an interesting topic of high-energy-density physics, and an essential aspect of Magnetized Target Fusion (MTF). To examine plasma formation from conductors impinged upon by ultrahigh magnetic fields, in a geometry similar to that of the MAGO experiments, an experiment is under design to compress magnetic flux in a toroidal cavity, using the Shiva Star or Atlas generator. An initial toroidal bias magnetic field is provided by a current on a central conductor. The central current is generated by diverting a fraction of the liner current using an innovative inductive current divider, thus avoiding the need for an auxiliary power supply. A 50-mm-radius cylindrical aluminum liner implodes along glide planes with velocity of about 5 km/s. Inward liner motion causes electrical closure of the toroidal chamber, after which flux in the chamber is conserved and compressed, yielding magnetic fields of 2-3 MG. Plasma is generated on the liner and central rod surfaces by Ohmic heating. Diagnostics include B-dot probes, Faraday rotation, radiography, filtered photodiodes, and VUV spectroscopy. Optical access to the chamber is provided through small holes in the walls.

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-05-23

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities ; International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) ;Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis;Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-06-20

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation, Cross section measurements, Experimental techniques, Uncertainties and covariances, Fission properties, and Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France), T. Belgya (IKI KFKI, Hungary), E. Gonzalez (CIEMAT, Spain), F. Gunsing (CEA, France), F.-J. Hambsch (IRMM, Belgium), A. Junghans (FZD, Germany), R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman), Marco Calviani, Samuel Andriamonje, Eric Berthoumieux, Carlos Guerrero, Roberto Losito, Vasilis Vlachoudis. Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Garbil, Roger

2018-04-16

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden). Workshop Organizing Committee: Enrico Chiaveri (Chairman); Marco Calviani; Samuel Andriamonje; Eric Berthoumieux; Carlos Guerrero; Roberto Losito; Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Lantz, Mattias; Neudecker, Denise

2018-05-25

Part 5 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean

Final Scientific EFNUDAT Workshop

ScienceCinema

Wilson, J.N.

2018-05-24

Part 7 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities;International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman) Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean.

Novel devices for solvent delivery and temperature programming designed for capillary liquid chromatography.

PubMed

Coutinho, Lincoln Figueira Marins; Nazario, Carlos Eduardo Domingues; Monteiro, Alessandra Maffei; Lanças, Fernando Mauro

2014-08-01

Analyses in chromatographic systems able to save mobile and stationary phases without reducing efficiency and resolution are of current interest. These advantages regarding savings have challenged us to develop a system dedicated to miniaturized liquid chromatography. This paper reports on the development of a high-pressure syringe-type pump, an oven able to perform isothermal and temperature programming and a software program to control these chromatographic devices. The experimental results show that the miniaturized system can generate reproducible and accurate temperature and flow rate. The system was applied to the separation of statins and tetracylines and showed excellent performance. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Enhancing the Introductory Astronomical Experience with the Use of a Tablet and Telescope

NASA Astrophysics Data System (ADS)

Gill, Robert M.; Burin, Michael J.

2013-02-01

College and university general education (GE) classes are designed to broaden the understanding of all college and university students in areas outside their major interest. However, most GE classes are lecture type and do not facilitate hands-on experimental or observational activities related to the specific subject matter. Utilizing astronomy application programs (apps), currently available for the iPad and iPhone, in conjunction with a small inexpensive telescope, allows students unique hands-on experiences to explore and observe astronomical objects and concepts independently outside of class. These activities enhance the students' overall GE experience in a unique way not possible prior to the development of these technologies.

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2018-05-24

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) & Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean

Enhancing the Educational Astronomical Experience of Non-Science Majors With the Use of an iPad and Telescope (Abstract)

NASA Astrophysics Data System (ADS)

Gill, R. M.; Burin, M. J.

2012-12-01

General Education (GE) classes are designed to broaden the understanding of all college and university students in areas outside their major interest. However, most GE classes are lecture type and do not facilitate hands-on experimental or observational activities related to the specific subject matter. Utilizing several astronomy application programs (apps), currently available for the iPad and iPhone, in conjunction with a small inexpensive telescope allows students unique hands-on experiences to explore and observe astronomical objects and concepts independently outside of class. These activities enhance the student's overall GE experience in a unique way not possible prior to the development of this technology.

Valley filters, accumulators, and switches induced in graphene quantum dots by lines of adsorbed hydrogen atoms

NASA Astrophysics Data System (ADS)

Azari, Mohammadhadi; Kirczenow, George

2018-06-01

We present electronic structure and quantum transport calculations that predict conducting channels induced in graphene quantum dots by lines of adsorbed hydrogen atoms to function as highly efficient, experimentally realizable valley filters, accumulators, and switches. The underlying physics is an interesting property of graphene Dirac point resonances (DPRs) that is revealed here, namely, that an electric current passing through a DPR-mediated conducting channel in a given direction is carried by electrons of only one of the two graphene valleys. Our predictions apply to lines of hydrogen atoms adsorbed on graphene quantum dots that are either free standing or supported on a hexagonal boron nitride substrate.

Decay of standard-model-like Higgs boson h →μ τ in a 3-3-1 model with inverse seesaw neutrino masses

NASA Astrophysics Data System (ADS)

Nguyen, T. Phong; Le, T. Thuy; Hong, T. T.; Hue, L. T.

2018-04-01

By adding new gauge singlets of neutral leptons, the improved versions of the 3-3-1 models with right-handed neutrinos have been recently introduced in order to explain recent experimental neutrino oscillation data through the inverse seesaw mechanism. We prove that these models predict promising signals of lepton-flavor-violating decays of the standard-model-like Higgs boson h10→μ τ ,e τ , which are suppressed in the original versions. One-loop contributions to these decay amplitudes are introduced in the unitary gauge. Based on a numerical investigation, we find that the branching ratios of the decays h10→μ τ ,e τ can reach values of 10-5 in the regions of parameter space satisfying the current experimental data of the decay μ →e γ . The value of 10-4 appears when the Yukawa couplings of leptons are close to the perturbative limit. Some interesting properties of these regions of parameter space are also discussed.

Empirical Approach for Determining Axial Strength of Circular Concrete Filled Steel Tubular Columns

NASA Astrophysics Data System (ADS)

Jayalekshmi, S.; Jegadesh, J. S. Sankar; Goel, Abhishek

2018-06-01

The concrete filled steel tubular (CFST) columns are highly regarded in recent years as an interesting option in the construction field by designers and structural engineers, due to their exquisite structural performance, with enhanced load bearing capacity and energy absorption capacity. This study presents a new approach to simulate the capacity of circular CFST columns under axial loading condition, using a large database of experimental results by applying artificial neural network (ANN). A well trained network is established and is used to simulate the axial capacity of CFST columns. The validation and testing of the ANN is carried out. The current study is focused on proposing a simplified equation that can predict the ultimate strength of the axially loaded columns with high level of accuracy. The predicted results are compared with five existing analytical models which estimate the strength of the CFST column. The ANN-based equation has good prediction with experimental data, when compared with the analytical models.

Human movement analysis using stereophotogrammetry. Part 1: theoretical background.

PubMed

Cappozzo, Aurelio; Della Croce, Ugo; Leardini, Alberto; Chiari, Lorenzo

2005-02-01

This paper sets the stage for a series of reviews dealing with the problems associated with the reconstruction and analysis of in vivo skeletal system kinematics using optoelectronic stereophotogrammetric data. Instantaneous bone position and orientation and joint kinematic variable estimations are addressed in the framework of rigid body mechanics. The conceptual background to these exercises is discussed. Focus is placed on the experimental and analytical problem of merging the information relative to movement and that relative to the morphology of the anatomical body parts of interest. The various global and local frames that may be used in this context are defined. Common anatomical and mathematical conventions that can be used to describe joint kinematics are illustrated in a comparative fashion. The authors believe that an effort to systematize the different theoretical and experimental approaches to the problems involved and related nomenclatures, as currently reported in the literature, is needed to facilitate data and knowledge sharing, and to provide renewed momentum for the advancement of human movement analysis.

Laser SRS tracker for reverse prototyping tasks

NASA Astrophysics Data System (ADS)

Kolmakov, Egor; Redka, Dmitriy; Grishkanich, Aleksandr; Tsvetkov, Konstantin

2017-10-01

According to the current great interest concerning Large-Scale Metrology applications in many different fields of manufacturing industry, technologies and techniques for dimensional measurement have recently shown a substantial improvement. Ease-of-use, logistic and economic issues, as well as metrological performance, are assuming a more and more important role among system requirements. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of chip and microlasers as radiators on the linear-angular characteristics of existing measurement systems. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of microlasers as radiators on the linear-angular characteristics of existing measurement systems. The system consists of a distributed network-based layout, whose modularity allows to fit differently sized and shaped working volumes by adequately increasing the number of sensing units. Differently from existing spatially distributed metrological instruments, the remote sensor devices are intended to provide embedded data elaboration capabilities, in order to share the overall computational load.

Mermin inequalities for GHZ contradictions in many-qutrit systems

NASA Astrophysics Data System (ADS)

Lawrence, Walter

In view of recent experimental interest in multi-qutrit entanglement properties, we provide here new Mermin inequalities for use in experimental tests of many-qutrit GHZ contradictions, first predicted only recently (2013). Mermin inequalities refer here to Bell-like inequalities in which the quantum predictions are not probabilistic, thus elevating hidden variables to the status of EPR elements of reality. Earlier Bell inequalities for qutrits predate the discovery of GHZ contradictions, are based on non-concurrent observable sets, and hence cannot establish GHZ contradictions. The current Mermin inequalities are derived from those concurrent observable sets which produce GHZ contradictions, with the following results: (i) There is an operator M defined for every N >= 4 , built on two measurement bases, whose quantum eigenvalue grows as 2N, maximum classical value more slowly (1 .879N), with quantum to classical ratio being never less than 1.39, and (ii) For N = 3 , there is an M3, built on three local measurement bases, whose quantum to classical ratio is 3/2.

From catalepsy to psychical research: The itinerary of Timothée Puel (1812-1890).

PubMed

Evrard, Renaud; Pratte, Erika Annabelle

2017-02-01

The physician and botanist Timothée Puel (1812-1890) lived through a pivotal period of psychology (1848-1878), between the academic prohibition of the study of animal magnetism to its disjointed recovery in hypnotism and psychical research. One of his cases of "catalepsy complicated with somnambulism" triggered a lively debate on "extraordinary neuroses" within the young Société médico-psychologique [Medico-psychological Society]. In 1874, Puel founded the Revue de psychologie expérimentale [Journal of Experimental Psychology], the first of its kind in French, which he intended as the vehicle of international interest in psychical research, the scholarly and institutionalized study of "psychism" that prepared the way for the recognition of academic psychology. Puel circulated between these different currents by taking advantage of the polysemy of concepts like "sleep," "experimental psychology," and "psychism." This article discusses his role in the context of emerging French psychology in the mid- to late 19th century. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Sexual differences in food preferences in the white stork: an experimental study

NASA Astrophysics Data System (ADS)

Kwieciński, Zbigniew; Rosin, Zuzanna M.; Dylewski, Łukasz; Skórka, Piotr

2017-06-01

Sex differences in the foraging ecology of monomorphic species are poorly understood, due to problems with gender identification in field studies. In the current study, we used experimental conditions to investigate the food preferences of the white stork Ciconia ciconia, an opportunistic species in terms of food, but characterised by a low level of sexual dimorphism. During a 10-day experiment, 29 individuals (20 females and 9 males) were studied by means of a `cafeteria test' in which the storks' diet consisted of mammals, birds, fish, amphibians, insects and earthworms. The storks preferred food characterised by high calorific and protein values such as mammals, birds and fish. Sexes differed strongly in their preferences; males preferred mammals, whereas females preferred birds. Moreover, females consumed insects and earthworms less often than males. Interestingly, males spent significantly less time foraging than females. We have demonstrated that the white stork exhibits clear sexual differences in food preferences which are mostly attributable to differences in parental duties, physiology and anatomy.

Conformation-driven quantum interference effects mediated by through-space conjugation in self-assembled monolayers

NASA Astrophysics Data System (ADS)

Carlotti, Marco; Kovalchuk, Andrii; Wächter, Tobias; Qiu, Xinkai; Zharnikov, Michael; Chiechi, Ryan C.

2016-12-01

Tunnelling currents through tunnelling junctions comprising molecules with cross-conjugation are markedly lower than for their linearly conjugated analogues. This effect has been shown experimentally and theoretically to arise from destructive quantum interference, which is understood to be an intrinsic, electronic property of molecules. Here we show experimental evidence of conformation-driven interference effects by examining through-space conjugation in which π-conjugated fragments are arranged face-on or edge-on in sufficiently close proximity to interact through space. Observing these effects in the latter requires trapping molecules in a non-equilibrium conformation closely resembling the X-ray crystal structure, which we accomplish using self-assembled monolayers to construct bottom-up, large-area tunnelling junctions. In contrast, interference effects are completely absent in zero-bias simulations on the equilibrium, gas-phase conformation, establishing through-space conjugation as both of fundamental interest and as a potential tool for tuning tunnelling charge-transport in large-area, solid-state molecular-electronic devices.

Improving membrane protein expression by optimizing integration efficiency

PubMed Central

2017-01-01

The heterologous overexpression of integral membrane proteins in Escherichia coli often yields insufficient quantities of purifiable protein for applications of interest. The current study leverages a recently demonstrated link between co-translational membrane integration efficiency and protein expression levels to predict protein sequence modifications that improve expression. Membrane integration efficiencies, obtained using a coarse-grained simulation approach, robustly predicted effects on expression of the integral membrane protein TatC for a set of 140 sequence modifications, including loop-swap chimeras and single-residue mutations distributed throughout the protein sequence. Mutations that improve simulated integration efficiency were 4-fold enriched with respect to improved experimentally observed expression levels. Furthermore, the effects of double mutations on both simulated integration efficiency and experimentally observed expression levels were cumulative and largely independent, suggesting that multiple mutations can be introduced to yield higher levels of purifiable protein. This work provides a foundation for a general method for the rational overexpression of integral membrane proteins based on computationally simulated membrane integration efficiencies. PMID:28918393

Polymorphism in Elemental Silicon: Probabilistic Interpretation of the Realizability of Metastable Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stevanovic, Vladan; Jones, Eric

With few systems of technological interest having been studied as extensively as elemental silicon, there currently exists a wide disparity between the number of predicted low-energy silicon polymorphs and those that have been experimentally realized as metastable at ambient conditions. We put forward an explanation for this disparity wherein the likelihood of formation of a given polymorph under near-equilibrium conditions can be estimated on the basis of mean-field isothermal-isobaric (N,p,T) ensemble statistics. The probability that a polymorph will be experimentally realized is shown to depend upon both the hypervolume of that structure's potential energy basin of attraction and a Boltzmannmore » factor weight containing the polymorph's potential enthalpy per particle. Both attributes are calculated using density functional theory relaxations of randomly generated initial structures. We find that the metastable polymorphism displayed by silicon can be accounted for using this framework to the exclusion of a very large number of other low-energy structures.« less

First experimental evidence of hydrodynamic tunneling of ultra-relativistic protons in extended solid copper target at the CERN HiRadMat facility

NASA Astrophysics Data System (ADS)

Schmidt, R.; Blanco Sancho, J.; Burkart, F.; Grenier, D.; Wollmann, D.; Tahir, N. A.; Shutov, A.; Piriz, A. R.

2014-08-01

A novel experiment has been performed at the CERN HiRadMat test facility to study the impact of the 440 GeV proton beam generated by the Super Proton Synchrotron on extended solid copper cylindrical targets. Substantial hydrodynamic tunneling of the protons in the target material has been observed that leads to significant lengthening of the projectile range, which confirms our previous theoretical predictions [N. A. Tahir et al., Phys. Rev. Spec. Top.-Accel. Beams 15, 051003 (2012)]. Simulation results show very good agreement with the experimental measurements. These results have very important implications on the machine protection design for powerful machines like the Large Hadron Collider (LHC), the future High Luminosity LHC, and the proposed huge 80 km circumference Future Circular Collider, which is currently being discussed at CERN. Another very interesting outcome of this work is that one may also study the field of High Energy Density Physics at this test facility.

Topical review: spins and mechanics in diamond

NASA Astrophysics Data System (ADS)

Lee, Donghun; Lee, Kenneth W.; Cady, Jeffrey V.; Ovartchaiyapong, Preeti; Bleszynski Jayich, Ania C.

2017-03-01

There has been rapidly growing interest in hybrid quantum devices involving a solid-state spin and a macroscopic mechanical oscillator. Such hybrid devices create exciting opportunities to mediate interactions between disparate quantum bits (qubits) and to explore the quantum regime of macroscopic mechanical objects. In particular, a system consisting of the nitrogen-vacancy defect center (NV center) in diamond coupled to a high-quality-factor mechanical oscillator is an appealing candidate for such a hybrid quantum device, as it utilizes the highly coherent and versatile spin properties of the defect center. In this paper, we will review recent experimental progress on diamond-based hybrid quantum devices in which the spin and orbital dynamics of single defects are driven by the motion of a mechanical oscillator. In addition, we discuss prospective applications for this device, including long-range, phonon-mediated spin-spin interactions, and phonon cooling in the quantum regime. We conclude the review by evaluating the experimental limitations of current devices and identifying alternative device architectures that may reach the strong coupling regime.

Free-Space Quantum Signatures Using Heterodyne Measurements

NASA Astrophysics Data System (ADS)

Croal, Callum; Peuntinger, Christian; Heim, Bettina; Khan, Imran; Marquardt, Christoph; Leuchs, Gerd; Wallden, Petros; Andersson, Erika; Korolkova, Natalia

2016-09-01

Digital signatures guarantee the authorship of electronic communications. Currently used "classical" signature schemes rely on unproven computational assumptions for security, while quantum signatures rely only on the laws of quantum mechanics to sign a classical message. Previous quantum signature schemes have used unambiguous quantum measurements. Such measurements, however, sometimes give no result, reducing the efficiency of the protocol. Here, we instead use heterodyne detection, which always gives a result, although there is always some uncertainty. We experimentally demonstrate feasibility in a real environment by distributing signature states through a noisy 1.6 km free-space channel. Our results show that continuous-variable heterodyne detection improves the signature rate for this type of scheme and therefore represents an interesting direction in the search for practical quantum signature schemes. For transmission values ranging from 100% to 10%, but otherwise assuming an ideal implementation with no other imperfections, the signature length is shorter by a factor of 2 to 10. As compared with previous relevant experimental realizations, the signature length in this implementation is several orders of magnitude shorter.

High Power MPD Thruster Development at the NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

LaPointe, Michael R.; Mikellides, Pavlos G.; Reddy, Dhanireddy (Technical Monitor)

2001-01-01

Propulsion requirements for large platform orbit raising, cargo and piloted planetary missions, and robotic deep space exploration have rekindled interest in the development and deployment of high power electromagnetic thrusters. Magnetoplasmadynamic (MPD) thrusters can effectively process megawatts of power over a broad range of specific impulse values to meet these diverse in-space propulsion requirements. As NASA's lead center for electric propulsion, the Glenn Research Center has established an MW-class pulsed thruster test facility and is refurbishing a high-power steady-state facility to design, build, and test efficient gas-fed MPD thrusters. A complimentary numerical modeling effort based on the robust MACH2 code provides a well-balanced program of numerical analysis and experimental validation leading to improved high power MPD thruster performance. This paper reviews the current and planned experimental facilities and numerical modeling capabilities at the Glenn Research Center and outlines program plans for the development of new, efficient high power MPD thrusters.

Empirical Approach for Determining Axial Strength of Circular Concrete Filled Steel Tubular Columns

NASA Astrophysics Data System (ADS)

Jayalekshmi, S.; Jegadesh, J. S. Sankar; Goel, Abhishek

2018-03-01

The concrete filled steel tubular (CFST) columns are highly regarded in recent years as an interesting option in the construction field by designers and structural engineers, due to their exquisite structural performance, with enhanced load bearing capacity and energy absorption capacity. This study presents a new approach to simulate the capacity of circular CFST columns under axial loading condition, using a large database of experimental results by applying artificial neural network (ANN). A well trained network is established and is used to simulate the axial capacity of CFST columns. The validation and testing of the ANN is carried out. The current study is focused on proposing a simplified equation that can predict the ultimate strength of the axially loaded columns with high level of accuracy. The predicted results are compared with five existing analytical models which estimate the strength of the CFST column. The ANN-based equation has good prediction with experimental data, when compared with the analytical models.

Analysis of an experiment aimed at improving the reliability of transmission centre shafts.

PubMed

Davis, T P

1995-01-01

Smith (1991) presents a paper proposing the use of Weibull regression models to establish dependence of failure data (usually times) on covariates related to the design of the test specimens and test procedures. In his article Smith made the point that good experimental design was as important in reliability applications as elsewhere, and in view of the current interest in design inspired by Taguchi and others, we pay some attention in this article to that topic. A real case study from the Ford Motor Company is presented. Our main approach is to utilize suggestions in the literature for applying standard least squares techniques of experimental analysis even when there is likely to be nonnormal error, and censoring. This approach lacks theoretical justification, but its appeal is its simplicity and flexibility. For completeness we also include some analysis based on the proportional hazards model, and in an attempt to link back to Smith (1991), look at a Weibull regression model.

From head to tail: new models and approaches in primate functional anatomy and biomechanics.

PubMed

Organ, Jason M; Deleon, Valerie B; Wang, Qian; Smith, Timothy D

2010-04-01

This special issue of The Anatomical Record (AR) is based on interest generated by a symposium at the 2008 annual meeting of the American Association of Anatomists (AAA) at Experimental Biology, entitled "An Evolutionary Perspective on Human Anatomy." The development of this volume in turn provided impetus for a Biological Anthropology Mini-Meeting, organized by members of the AAA for the 2010 Experimental Biology meeting in Anaheim, California. The research presented in these pages reflects the themes of these symposia and provides a snapshot of the current state of primate functional anatomy and biomechanics research. The 17 articles in this special issue utilize new models and/or approaches to study long-standing questions about the evolution of our closest relatives, including soft-tissue dissection and microanatomical techniques, experimental approaches to morphology, kinematic and kinetic biomechanics, high-resolution computed tomography, and Finite Element Analysis (FEA). This volume continues a close historical association between the disciplines of anatomy and biological anthropology: anatomists benefit from an understanding of the evolutionary history of our modern form, and biological anthropologists rely on anatomical principles to make informed evolutionary inferences about our closest relatives. (c) 2010 Wiley-Liss, Inc.

Standardizing practices: a socio-history of experimental systems in classical genetic and virological cancer research, ca. 1920-1978.

PubMed

Fujimura, J H

1996-01-01

This paper presents a narrative history of technologies in cancer research circa 1920-1978 and a theoretical perspective on the complex, intertwined relationships between scientific problems, material practices and technologies, concepts and theories, and other historical circumstances. The history presents several active lines of research and technology development in the genetics of cancer in the United States which were constitutive of proto-oncogene work in its current form. I write this history from the perspective of technology development. Scientists participating in cancer research created tools with which to study their problems of interest, but the development of the tools also influenced the questions asked and answered in the form of concepts and theories developed. These tools included genetic ideas of the 1920s, inbred mouse colonies, chemicals and antibiotics developed during World War Two, tissue cultures and their technical procedures, and viruses. I examine these tools as standardized experimental systems that standardized materials as well as practices in laboratories. Inbred animals, tissue culture materials and methods, and tumor viruses as experimental systems gave materiality to "genes' and "cancer'. They are technical-natural objects that stand-in for nature in the laboratory.

Bonn eXperimental System (BoXS): An open-source platform for interactive experiments in psychology and economics.

PubMed

Seithe, Mirko; Morina, Jeronim; Glöckner, Andreas

2016-12-01

The increased interest in complex-interactive behavior on the one hand and the cognitive and affective processes underlying behavior on the other are a challenge for researchers in psychology and behavioral economics. Research often necessitates that participants strategically interact with each other in dyads or groups. At the same time, to investigate the underlying cognitive and affective processes in a fine-grained manner, not only choices but also other variables such as decision time, information search, and pupil dilation should be recorded. The Bonn eXperimental System (BoXS) introduced in this article is an open-source platform that allows interactive as well as non-interactive experiments to be conducted while recording process measures very efficiently and completely browser-based. In the current version, BoXS has particularly been extended to enable conducting interactive eye-tracking and mouse-tracking experiments. One core advantage of BoXS is its simplicity. Using BoXS does not require prior installation for both experimenters and participants, which allows for running studies outside the laboratory and over the internet. Learning to program for BoXS is easy even for researchers without previous programming experience.

Temperature dependence of the enhanced inverse spin Hall voltage in Pt/Antiferromagnetic/ Y3Fe5O12

NASA Astrophysics Data System (ADS)

Brangham, J. T.; Lee, A. J.; Cheng, Y.; Yu, S. S.; Dunsiger, S. R.; Page, M. R.; Hammel, P. C.; Yang, F. Y.

The generation, propagation, and detection of spin currents are of intense interest in the field of spintronics. Spin current generation by FMR spin pumping using Y3Fe5O12 (YIG) and spin current detection by the inverse spin Hall effect (ISHE) in metals such as Pt have been well studied. This is due to YIG's exceptionally low damping and insulating behavior and the large spin Hall angle of Pt. Previously, our group showed that the ISHE voltages are significantly enhanced by adding a thin intermediate layer of an antiferromagnet (AFM) between Pt and YIG at room temperature. Recent theoretical work predicts a mechanism for this enhancement as well as the temperature dependence of the ISHE voltages of metal/AFM/YIG trilayers. The predictions show a maximum in the ISHE voltages for these systems near the magnetic phase transition temperature of the AFM. Here we present experimental results showing the temperature dependence for Pt/AFM/YIG structures with various AFMs. DOE Grant No. DE-SC0001304.

Spin transport across antiferromagnets induced by the spin Seebeck effect

NASA Astrophysics Data System (ADS)

Cramer, Joel; Ritzmann, Ulrike; Dong, Bo-Wen; Jaiswal, Samridh; Qiu, Zhiyong; Saitoh, Eiji; Nowak, Ulrich; Kläui, Mathias

2018-04-01

For prospective spintronics devices based on the propagation of pure spin currents, antiferromagnets are an interesting class of materials that potentially entail a number of advantages as compared to ferromagnets. Here, we present a detailed theoretical study of magnonic spin current transport in ferromagnetic-antiferromagnetic multilayers by using atomistic spin dynamics simulations. The relevant length scales of magnonic spin transport in antiferromagnets are determined. We demonstrate the transfer of angular momentum from a ferromagnet into an antiferromagnet due to the excitation of only one magnon branch in the antiferromagnet. As an experimental system, we ascertain the transport across an antiferromagnet in Y3Fe5O12 |Ir20Mn80|Pt heterostructures. We determine the spin transport signals for spin currents generated in the Y3Fe5O12 by the spin Seebeck effect and compare to measurements of the spin Hall magnetoresistance in the heterostructure stack. By means of temperature-dependent and thickness-dependent measurements, we deduce conclusions on the spin transport mechanism across Ir20Mn80 and furthermore correlate it to its paramagnetic-antiferromagnetic phase transition.

Eliciting Mathematics Interest: New Directions for Context Personalization and Example Choice

ERIC Educational Resources Information Center

Høgheim, Sigve; Reber, Rolf

2017-01-01

Building on common assumptions in theories of interest and mathematics education, this experimental study examined the effect of context personalization based on individual preferences, group personalization, and example choice with preselected popular examples on middle school students' situational interest and performance in mathematics.…

What proportion of people who try one cigarette become daily smokers? A meta analysis of representative surveys.

PubMed

Birge, Max; Duffy, Stephen; Miler, Joanna Astrid; Hajek, Peter

2017-11-04

The 'conversion rate' from initial experimentation to daily smoking is a potentially important metric of smoking behavior, but estimates of it based on current representative data are lacking. The Global Health Data Exchange was searched for representative surveys conducted in English speaking, developed countries after year 2000 that included questions about ever trying a cigarette and ever smoking daily. The initial search identified 2776 surveys that were further screened for language, location, year, sample size, survey structure and representativeness. 44 surveys that passed the screening process were accessed and their codebooks were examined to see whether the two questions of interest were included. Eight datasets allowed extraction or estimation of relevant information. Survey quality was assessed with regards to response rates, sampling methods and data collection procedures. PRISMA guidelines were followed, with explicit rules for approaching derived variables and skip patterns. Proportions were pooled using random effects meta-analysis. The eight surveys used representative samples of the general adult population. Response rates varied from 45% to 88%. Survey methods were on par with the best practice in this field. Altogether 216,314 respondents were included of whom 60.3% (95%CI 51.3-69.3) ever tried a cigarette. Among those, 68.9% (95% CI 60.9-76.9%) progressed to daily smoking. Over two thirds of people who try one cigarette become, at least temporarily, daily smokers. The finding provides strong support for the current efforts to reduce cigarette experimentation among adolescents. The transition from trying the first cigarette through occasional to daily smoking usually implies that a recreational activity is turning into a compulsive need that has to be satisfied virtually continuously. The 'conversion rate' from initial experimentation to daily smoking is thus a potentially important metric of smoking behavior, but estimates of it based on representative data are lacking. The present meta analysis addressed this gap. Currently, about two thirds of non-smokers experimenting with cigarettes progress to daily smoking. The finding supports strongly the current efforts to reduce cigarette experimentation among adolescents. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

76 FR 66758 - Remedies for Small Copyright Claims

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... legal system hinders or prevents copyright owners from pursuing copyright infringement claims that have... helpful and viable. A. Challenges of the Current Legal System Currently, copyright owners interested in... Office is interested in learning about alternatives to the current legal system that might help alleviate...

An experimental investigation of liquid methane convection and boiling in rocket engine cooling channels

NASA Astrophysics Data System (ADS)

Trujillo, Abraham Gerardo

In the past decades, interest in developing hydrocarbon-fueled rocket engines for deep spaceflight missions has continued to grow. In particular, liquid methane (LCH4) has been of interest due to the weight efficiency, storage, and handling advantages it offers over several currently used propellants. Deep space exploration requires reusable, long life rocket engines. Due to the high temperatures reached during combustion, the life of an engine is significantly impacted by the cooling system's efficiency. Regenerative (regen) cooling is presented as a viable alternative to common cooling methods such as film and dump cooling since it provides improved engine efficiency. Due to limited availability of experimental sub-critical liquid methane cooling data for regen engine design, there has been an interest in studying the heat transfer characteristics of the propellant. For this reason, recent experimental studies at the Center for Space Exploration Technology Research (cSETR) at the University of Texas at El Paso (UTEP) have focused on investigating the heat transfer characteristics of sub-critical CH4 flowing through sub-scale cooling channels. To conduct the experiments, the csETR developed a High Heat Flux Test Facility (HHFTF) where all the channels are heated using a conduction-based thermal concentrator. In this study, two smooth channels with cross sectional geometries of 1.8 mm x 4.1 mm and 3.2 mm x 3.2 mm were tested. In addition, three roughened channels all with a 3.2 mm x 3.2 mm square cross section were also tested. For the rectangular smooth channel, Reynolds numbers ranged between 68,000 and 131,000, while the Nusselt numbers were between 40 and 325. For the rough channels, Reynolds numbers ranged from 82,000 to 131,000, and Nusselt numbers were between 65 and 810. Sub-cooled film-boiling phenomena were confirmed for all the channels presented in this work. Film-boiling onset at Critical Heat Flux (CHF) was correlated to a Boiling Number (Bo) of approximately 0.1 for all channels. Convective Nusselt number follows predicted trends for Reynolds number with a wall temperature correction for both the boiling and non-boiling regimes.

Education in the Field Influences Children's Ideas and Interest toward Science

NASA Astrophysics Data System (ADS)

Zoldosova, Kristina; Prokop, Pavol

2006-10-01

This paper explores the idea of informal science education in scientific field laboratory (The Science Field Centre). The experimental group of pupils ( N = 153) was experienced with approximately 5-day lasting field trips and experiments in the Field Centre in Slovakia. After finishing the course, two different research methods were used to discover their interest and ideas toward science. Pupils from the experimental group showed significant differences from those that did not experience education in the Field Centre (control group, N = 365). In comparison to the control group, pupils of the experimental group highly preferred book titles that were related to their program in the Field Centre. There were differences between the drawings of ideal school environment from both pupils groups. In the drawings of the experimental group, we found significantly more items connected with the educational environment of the Field Centre (e.g. laboratory equipment, live animals). We suppose field science education would be one of the most effective ways to increase interest of pupils to study science and to invaluable intrinsic motivation at the expense extrinsic motivation.

Translating Fatigue to Human Performance.

PubMed

Enoka, Roger M; Duchateau, Jacques

2016-11-01

Despite flourishing interest in the topic of fatigue-as indicated by the many presentations on fatigue at the 2015 Annual Meeting of the American College of Sports Medicine-surprisingly little is known about its effect on human performance. There are two main reasons for this dilemma: 1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and 2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. On the basis of the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability affect real-world performance.

Effects of validating communication on recall during a pain-task in healthy participants.

PubMed

Carstens, Johan K P; Boersma, Katja; Schrooten, Martien G S; Linton, Steven J

2017-10-01

Increasing recall of instructions and advice in a pain consultation is important, since it is a prerequisite for adherence to treatment recommendations. However, interference due to pain-related distress may result in poor recall. Whereas there are some indications that recall can be increased by empathic communication that reduces interference, this interesting possibility remains largely untested experimentally. The current experiment aimed at studying effects of empathic communication, and more specifically validation, on recall during a pain test and possible mediators and moderators of this effect. Participants received either validating (N=25) or invalidating responses (N=25) from the experimenter during a pain provoking task, followed by self-report measures of interference (affect, situational pain catastrophizing) and recall (accurate and false memories of words). As expected, the validated group exhibited higher accurate recall and less false memories following the pain test as compared to the invalidated group. This was partly due to the effect of interference being counteracted by moderating the relationship between pain catastrophizing and recall. These novel results suggest that validating communication can counteract interference due to pain catastrophizing on recall, at least in a controlled experimental setting. Good communication by health professionals is of utmost importance for adherence to pain management. The current results expand our knowledge on the effects of pain communication by establishing and explaining a clear link between empathic communication and recall, highlighting the role of pain catastrophizing. Copyright © 2017 Scandinavian Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Translating Fatigue to Human Performance

PubMed Central

Enoka, Roger M.; Duchateau, Jacques

2016-01-01

Despite flourishing interest in the topic of fatigue—as indicated by the many presentations on fatigue at the 2015 annual meeting of the American College of Sports Medicine—surprisingly little is known about its impact on human performance. There are two main reasons for this dilemma: (1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and (2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. Based on the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability impact real-world performance. PMID:27015386

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

PubMed Central

Davis, Esther F.; Newton, Laura; Lewandowski, Adam J.; Lazdam, Merzaka; Kelly, Brenda A.; Kyriakou, Theodosios; Leeson, Paul

2012-01-01

Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2–5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu. PMID:22455350

5 CFR 831.613 - Election of insurable interest annuity.

Code of Federal Regulations, 2013 CFR

2013-01-01

... insurable interest annuity is cancelled if— (i) The retiree fails to qualify to receive the insurable... insurable interest is presumed to exist with— (i) The current spouse; (ii) The current same-sex domestic... same-sex domestic partner; (vi) A person to whom the employee or Member is engaged to be married, or a...

5 CFR 831.613 - Election of insurable interest annuity.

Code of Federal Regulations, 2014 CFR

2014-01-01

... insurable interest annuity is cancelled if— (i) The retiree fails to qualify to receive the insurable... insurable interest is presumed to exist with— (i) The current spouse; (ii) The current same-sex domestic... same-sex domestic partner; (vi) A person to whom the employee or Member is engaged to be married, or a...

Exploring the Development of College Students' Situational Interest in Learning Science

ERIC Educational Resources Information Center

Lin, Huann-shyang; Hong, Zuway-R; Chen, Ya-Chun

2013-01-01

This quasi-experimental study explores how student cumulative situational interest, short-term preference generated by particular conditions such as novel experiences can be developed into better individual interest, an enduring predisposition to engage in certain activity such as chemistry lessons. A continuous intervention of integrating novelty…

Cigarette users' interest in using or switching to electronic nicotine delivery systems for smokeless tobacco for harm reduction, cessation, or novelty: a cross-sectional survey of US adults.

PubMed

Berg, Carla J; Haardoerfer, Regine; Escoffery, Cam; Zheng, Pinpin; Kegler, Michelle

2015-02-01

We examined: (a) current (past 30-day) smokers' interest in using or switching to electronic nicotine delivery systems (ENDS) or smokeless tobacco for various reasons; (b) correlates of interest in these products; and (c) subgroups of current smokers in relation to interest in these products. We conducted a cross-sectional survey assessing sociodemographics, tobacco use, interest in ENDS and smokeless tobacco among smokers, and knowledge about ENDS among 2,501 US adults recruited through an online consumer panel. We oversampled tobacco users (36.7% current cigarette smokers), ethnic minorities, and southeastern US state residents. On average, participants were more interested in ENDS than smokeless tobacco across all reasons provided. Additionally, they were less interested in either product because of their potential use in places prohibiting smoking or due to curiosity and more interested in reducing health risk or cigarette consumption or to aid in cessation. We documented high rates (27.9%) of misbeliefs about Food and Drug Administration approval of ENDS for cessation, particularly among current smokers (38.5%). Also, 27.2% of current smokers had talked with a health care provider about ENDS, with 18.0% reporting that their provider endorsed ENDS use for cessation. Furthermore, cluster analyses revealed 3 groups distinct in their interest in the products, sociodemographics, and smoking-related characteristics. This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical. © The Author 2014. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Numerical and experimental modelling of the radial compressor stage

NASA Astrophysics Data System (ADS)

Syka, Tomáš; Matas, Richard; LuÅáček, Ondřej

2016-06-01

This article deals with the description of the numerical and experimental model of the new compressor stage designed for process centrifugal compressors. It's the first member of the new stages family developed to achieve the state of the art thermodynamic parameters. This stage (named RTK01) is designed for high flow coefficient with 3D shaped impeller blades. Some interesting findings were gained during its development. The article is focused mainly on some interesting aspects of the development methodology and numerical simulations improvement, not on the specific stage properties. Conditions and experimental equipment, measured results and their comparison with ANSYS CFX and NUMECA FINE/Turbo CFD simulations are described.

Experimental design methods for bioengineering applications.

PubMed

Keskin Gündoğdu, Tuğba; Deniz, İrem; Çalışkan, Gülizar; Şahin, Erdem Sefa; Azbar, Nuri

2016-01-01

Experimental design is a form of process analysis in which certain factors are selected to obtain the desired responses of interest. It may also be used for the determination of the effects of various independent factors on a dependent factor. The bioengineering discipline includes many different areas of scientific interest, and each study area is affected and governed by many different factors. Briefly analyzing the important factors and selecting an experimental design for optimization are very effective tools for the design of any bioprocess under question. This review summarizes experimental design methods that can be used to investigate various factors relating to bioengineering processes. The experimental methods generally used in bioengineering are as follows: full factorial design, fractional factorial design, Plackett-Burman design, Taguchi design, Box-Behnken design and central composite design. These design methods are briefly introduced, and then the application of these design methods to study different bioengineering processes is analyzed.

Direct observation of turbulent magnetic fields in hot, dense laser produced plasmas

PubMed Central

Mondal, Sudipta; Narayanan, V.; Ding, Wen Jun; Lad, Amit D.; Hao, Biao; Ahmad, Saima; Wang, Wei Min; Sheng, Zheng Ming; Sengupta, Sudip; Kaw, Predhiman; Das, Amita; Kumar, G. Ravindra

2012-01-01

Turbulence in fluids is a ubiquitous, fascinating, and complex natural phenomenon that is not yet fully understood. Unraveling turbulence in high density, high temperature plasmas is an even bigger challenge because of the importance of electromagnetic forces and the typically violent environments. Fascinating and novel behavior of hot dense matter has so far been only indirectly inferred because of the enormous difficulties of making observations on such matter. Here, we present direct evidence of turbulence in giant magnetic fields created in an overdense, hot plasma by relativistic intensity (1018W/cm2) femtosecond laser pulses. We have obtained magneto-optic polarigrams at femtosecond time intervals, simultaneously with micrometer spatial resolution. The spatial profiles of the magnetic field show randomness and their k spectra exhibit a power law along with certain well defined peaks at scales shorter than skin depth. Detailed two-dimensional particle-in-cell simulations delineate the underlying interaction between forward currents of relativistic energy “hot” electrons created by the laser pulse and “cold” return currents of thermal electrons induced in the target. Our results are not only fundamentally interesting but should also arouse interest on the role of magnetic turbulence induced resistivity in the context of fast ignition of laser fusion, and the possibility of experimentally simulating such structures with respect to the sun and other stellar environments. PMID:22566660

Direct observation of turbulent magnetic fields in hot, dense laser produced plasmas.

PubMed

Mondal, Sudipta; Narayanan, V; Ding, Wen Jun; Lad, Amit D; Hao, Biao; Ahmad, Saima; Wang, Wei Min; Sheng, Zheng Ming; Sengupta, Sudip; Kaw, Predhiman; Das, Amita; Kumar, G Ravindra

2012-05-22

Turbulence in fluids is a ubiquitous, fascinating, and complex natural phenomenon that is not yet fully understood. Unraveling turbulence in high density, high temperature plasmas is an even bigger challenge because of the importance of electromagnetic forces and the typically violent environments. Fascinating and novel behavior of hot dense matter has so far been only indirectly inferred because of the enormous difficulties of making observations on such matter. Here, we present direct evidence of turbulence in giant magnetic fields created in an overdense, hot plasma by relativistic intensity (10(18) W/cm(2)) femtosecond laser pulses. We have obtained magneto-optic polarigrams at femtosecond time intervals, simultaneously with micrometer spatial resolution. The spatial profiles of the magnetic field show randomness and their k spectra exhibit a power law along with certain well defined peaks at scales shorter than skin depth. Detailed two-dimensional particle-in-cell simulations delineate the underlying interaction between forward currents of relativistic energy "hot" electrons created by the laser pulse and "cold" return currents of thermal electrons induced in the target. Our results are not only fundamentally interesting but should also arouse interest on the role of magnetic turbulence induced resistivity in the context of fast ignition of laser fusion, and the possibility of experimentally simulating such structures with respect to the sun and other stellar environments.

Operation of Direct Drive Systems: Experiments in Peak Power Tracking and Multi-Thruster Control

NASA Technical Reports Server (NTRS)

Snyder, John Steven; Brophy, John R.

2013-01-01

Direct-drive power and propulsion systems have the potential to significantly reduce the mass of high-power solar electric propulsion spacecraft, among other advantages. Recent experimental direct-drive work has significantly mitigated or retired the technical risks associated with single-thruster operation, so attention is now moving toward systems-level areas of interest. One of those areas is the use of a Hall thruster system as a peak power tracker to fully use the available power from a solar array. A simple and elegant control based on the incremental conductance method, enhanced by combining it with the unique properties of Hall thruster systems, is derived here and it is shown to track peak solar array power very well. Another area of interest is multi-thruster operation and control. Dualthruster operation was investigated in a parallel electrical configuration, with both thrusters operating from discharge power provided by a single solar array. Startup and shutdown sequences are discussed, and it is shown that multi-thruster operation and control is as simple as for a single thruster. Some system architectures require operation of multiple cathodes while they are electrically connected together. Four different methods to control the discharge current emitted by individual cathodes in this configuration are investigated, with cathode flow rate control appearing to be advantageous. Dual-parallel thruster operation with equal cathode current sharing at total powers up to 10 kW is presented.

Inclusion of quasi-experimental studies in systematic reviews of health systems research.

PubMed

Rockers, Peter C; Røttingen, John-Arne; Shemilt, Ian; Tugwell, Peter; Bärnighausen, Till

2015-04-01

Systematic reviews of health systems research commonly limit studies for evidence synthesis to randomized controlled trials. However, well-conducted quasi-experimental studies can provide strong evidence for causal inference. With this article, we aim to stimulate and inform discussions on including quasi-experiments in systematic reviews of health systems research. We define quasi-experimental studies as those that estimate causal effect sizes using exogenous variation in the exposure of interest that is not directly controlled by the researcher. We incorporate this definition into a non-hierarchical three-class taxonomy of study designs - experiments, quasi-experiments, and non-experiments. Based on a review of practice in three disciplines related to health systems research (epidemiology, economics, and political science), we discuss five commonly used study designs that fit our definition of quasi-experiments: natural experiments, instrumental variable analyses, regression discontinuity analyses, interrupted times series studies, and difference studies including controlled before-and-after designs, difference-in-difference designs and fixed effects analyses of panel data. We further review current practices regarding quasi-experimental studies in three non-health fields that utilize systematic reviews (education, development, and environment studies) to inform the design of approaches for synthesizing quasi-experimental evidence in health systems research. Ultimately, the aim of any review is practical: to provide useful information for policymakers, practitioners, and researchers. Future work should focus on building a consensus among users and producers of systematic reviews regarding the inclusion of quasi-experiments. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Particle Identification on an FPGA Accelerated Compute Platform for the LHCb Upgrade

NASA Astrophysics Data System (ADS)

Fäerber, Christian; Schwemmer, Rainer; Machen, Jonathan; Neufeld, Niko

2017-07-01

The current LHCb readout system will be upgraded in 2018 to a “triggerless” readout of the entire detector at the Large Hadron Collider collision rate of 40 MHz. The corresponding bandwidth from the detector down to the foreseen dedicated computing farm (event filter farm), which acts as the trigger, has to be increased by a factor of almost 100 from currently 500 Gb/s up to 40 Tb/s. The event filter farm will preanalyze the data and will select the events on an event by event basis. This will reduce the bandwidth down to a manageable size to write the interesting physics data to tape. The design of such a system is a challenging task, and the reason why different new technologies are considered and have to be investigated for the different parts of the system. For the usage in the event building farm or in the event filter farm (trigger), an experimental field programmable gate array (FPGA) accelerated computing platform is considered and, therefore, tested. FPGA compute accelerators are used more and more in standard servers such as for Microsoft Bing search or Baidu search. The platform we use hosts a general Intel CPU and a high-performance FPGA linked via the high-speed Intel QuickPath Interconnect. An accelerator is implemented on the FPGA. It is very likely that these platforms, which are built, in general, for high-performance computing, are also very interesting for the high-energy physics community. First, the performance results of smaller test cases performed at the beginning are presented. Afterward, a part of the existing LHCb RICH particle identification is tested and is ported to the experimental FPGA accelerated platform. We have compared the performance of the LHCb RICH particle identification running on a normal CPU with the performance of the same algorithm, which is running on the Xeon-FPGA compute accelerator platform.

Terminal illness and access to Phase 1 experimental agents, surgeries and devices: reviewing the ethical arguments.

PubMed

Schüklenk, Udo; Lowry, Christopher

2009-01-01

The advent of AIDS brought about a group of patients unwilling to accept crucial aspects of the methodological standards for clinical research investigating Phase 1 drugs, surgeries or devices. Their arguments against placebo controls in trials, which depended--at the time--on the terminal status of patient volunteers led to a renewed discussion of the ethics of denying patients with catastrophic illnesses access to last-chance experimental drugs, surgeries or devices. Existing ethics and health policy literature on the topic of access to experimental drugs. The positions of those arguing for or against free access to experimental drugs for terminally ill patients are irreconcilable. At stake are questions about the kinds of personal sacrifices society can reasonably expect patients in clinical trials to make to ensure statistically predictive results. These would benefit by necessity a much larger number of current and future patients--the conflict is about individual versus public interests. It is also about the question of whether or not the state can legitimately prevent patients with terminal illnesses from unfettered access to experimental drugs, surgeries or devices in order to motivate them to participate in clinical trials. We review the ethical arguments for and against the provision of access to Phase 1 agents for terminally ill patients. Finding a compromise between providing free or no access to Phase 1 drugs for terminally ill patients. We ought to investigate means to increase access to experimental drugs for terminally ill patients without sacrificing necessary clinical trials' sounds scientific methods.

Designing an Experimental "Accident"

ERIC Educational Resources Information Center

Picker, Lester

1974-01-01

Describes an experimental "accident" that resulted in much student learning, seeks help in the identification of nematodes, and suggests biology teachers introduce similar accidents into their teaching to stimulate student interest. (PEB)

g-factor measurements of isomeric states in 174W

NASA Astrophysics Data System (ADS)

Rocchini, M.; Nannini, A.; Benzoni, G.; Melon, B.; John, P. R.; Ur, C. A.; Avigo, R.; Bazzacco, D.; Blasi, N.; Bocchi, G.; Bottoni, S.; Bracco, A.; Camera, F.; Ceruti, S.; Crespi, F. C. L.; Georgiev, G.; Giaz, A.; Gottardo, A.; Leoni, S.; Menegazzo, R.; Mengoni, D.; Michelagnoli, C.; Million, B.; Modamio, V.; Morales, A. I.; Napoli, D. R.; Ottanelli, M.; Pellegri, L.; Perego, A.; Valiente-Dobon, J. J.; Wieland, O.

2016-05-01

The experimental setup GAMIPE used for gyro magnetic factor measurements at Laboratori Nazionali di Legnaro and a recent experimental work regarding K-isomers in 174W are described. Aim of the experiment is to study the detailed structure of the isomeric states wave functions, by the measurement of the magnetic dipole moments. This piece of information can provide interesting hints for theoretical models. Preliminary results concerning the population of the isomers of interest and half-lives are presented.

Physics Applied to Oil and Gas Exploration

NASA Astrophysics Data System (ADS)

Schwartz, Larry

2002-03-01

Problems involving transport in porous media are of interest throughout the fields of petroleum exploration and environmental monitoring and remediation. The systems being studied can vary in size from centimeter scale rock or soil samples to kilometer scale reservoirs and aquifers. Clearly, the smaller the sample the more easily can the medium's structure and composition be characterized, and the better defined are the associated experimental and theoretical modeling problems. The study of transport in such geological systems is then similar to corresponding problems in the study of other heterogeneous systems such as polymer gels, catalytic beds and cementitious materials. The defining characteristic of porous media is that they are comprised of two percolating interconnected channels, the solid and pore networks. Transport processes of interest in such systems typically involve the flow of electrical current, viscous fluids or fine grained particles. A closely related phenomena, nuclear magnetic resonance (NMR), is controlled by diffusion in the pore network. Also of interest is the highly non-linear character of the stress-strain response of granular porous media. We will review the development of two and three dimensional model porous media, and will outline the calculation of their physical properties. We will also discuss the direct measurement of the pore structure by synchrotron X-ray microtomography.

75 FR 58462 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of a Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... resting interest exceeds the Defined Limit, the Market Maker must enter new interest at a price not more than the Designated Percentage of 8% away from the NBBO (or identify to the Corporation current resting... Corporation current resting interest that satisfies the Market Maker's obligation). The Exchange proposes that...

Magnetism, spin-lattice-orbital coupling and exchange-correlation energy in oxide heterostructures: Nickelate, titanate, and ruthenate

NASA Astrophysics Data System (ADS)

Han, Myung-Joon

Many interesting physical phenomena and material characteristics in transition-metal oxides (TMO) come out of the intriguing interplay between charge, spin, orbital, and lattice degrees of freedom. In the thin film and/or heterointerface form of TMO, this feature can be controlled and thus be utilized. Simultaneously, however, its detailed characteristic is more difficult to be identified experimentally. For this reason, the first-principles-based approach has been playing an important role in this field of research. In this talk, I will try to give an overview of current status of first-principles methodologies especially for the magnetism in the correlated oxide heterostructures or thin films. Nickelate, titanate, and ruthenate will be taken as representative examples to demonstrate the powerfulness of and the challenges to the current methodologies On the one hand, first-principles calculation provides the useful information, understanding and prediction which can hardly be obtained from other theoretical and experimental techniques. Nickelate-manganite superlattices (LaNiO3/LaMnO3 and LaNiO3/CaMnO3) are taken as examples. In this interface, the charge transfer can induce the ferromagnetism and it can be controlled by changing the stacking sequence and number of layers. The exchange-correlation (XC) functional dependence seems to give only quantitatively different answers in this case. On the other hand, for the other issues such as orbital polarization/order coupled with spin order, the limitation of current methodology can be critical. This point will be discussed with the case of tatinate superlattice (LaTiO3/LaAlO3) . For ruthenates (SrRuO3\\ and Sr2RuO4) , we found that the probably more fundamental issue could be involved. The unusually strong dependence on the XC functional parametrization is found to give a qualitatively different conclusion for the experimentally relevant parameter regions. This work was supported by National Research Foundation of Korea (2014R1A1A2057202).

Deterministic analysis of processes at corroding metal surfaces and the study of electrochemical noise in these systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latanision, R.M.

1990-12-01

Electrochemical corrosion is pervasive in virtually all engineering systems and in virtually all industrial circumstances. Although engineers now understand how to design systems to minimize corrosion in many instances, many fundamental questions remain poorly understood and, therefore, the development of corrosion control strategies is based more on empiricism than on a deep understanding of the processes by which metals corrode in electrolytes. Fluctuations in potential, or current, in electrochemical systems have been observed for many years. To date, all investigations of this phenomenon have utilized non-deterministic analyses. In this work it is proposed to study electrochemical noise from a deterministicmore » viewpoint by comparison of experimental parameters, such as first and second order moments (non-deterministic), with computer simulation of corrosion at metal surfaces. In this way it is proposed to analyze the origins of these fluctuations and to elucidate the relationship between these fluctuations and kinetic parameters associated with metal dissolution and cathodic reduction reactions. This research program addresses in essence two areas of interest: (a) computer modeling of corrosion processes in order to study the electrochemical processes on an atomistic scale, and (b) experimental investigations of fluctuations in electrochemical systems and correlation of experimental results with computer modeling. In effect, the noise generated by mathematical modeling will be analyzed and compared to experimental noise in electrochemical systems. 1 fig.« less

Quasi-experimental study designs series-paper 12: strengthening global capacity for evidence synthesis of quasi-experimental health systems research.

PubMed

Rockers, Peter C; Tugwell, Peter; Grimshaw, Jeremy; Oliver, Sandy; Atun, Rifat; Røttingen, John-Arne; Fretheim, Atle; Ranson, M Kent; Daniels, Karen; Luiza, Vera Lucia; Bärnighausen, Till

2017-09-01

Evidence from quasi-experimental studies is often excluded from systematic reviews of health systems research despite the fact that such studies can provide strong causal evidence when well conducted. This article discusses global coordination of efforts to institutionalize the inclusion of causal evidence from quasi-experiments in systematic reviews of health systems research. In particular, we are concerned with identifying opportunities for strengthening capacity at the global and local level for implementing protocols necessary to ensure that reviews that include quasi-experiments are consistently of the highest quality. We first describe the current state of the global infrastructure that facilitates the production of systematic reviews of health systems research. We identify five important types of actors operating within this infrastructure: review authors; synthesis collaborations that facilitate the review process; synthesis interest groups that supplement the work of the larger collaborations; review funders; and end users, including policymakers. Then, we examine opportunities for intervening to build the capacity of each type of actors to support the inclusion of quasi-experiments in reviews. Finally, we suggest practical next steps for proceeding with capacity building efforts. Because of the complexity and relative nascence of the field, we recommend a carefully planned and executed approach to strengthening global capacity for the inclusion of quasi-experimental studies in systematic reviews. Copyright © 2017 Elsevier Inc. All rights reserved.

The Rehabilitation Counselor Scale: A New Scale for the Revised Strong Interest Inventory

ERIC Educational Resources Information Center

Leierer, Stephen J.; Strohmer, Douglas C.; Blackwell, Terry L.; Thompson, Richard C.; Donnay, David A. C.

2008-01-01

The vocational interests of rehabilitation counselors were explored by developing an occupational scale for the "Strong Interest Inventory, Revised Edition" (SII; 2004). A sample of 414 rehabilitation counselors who were satisfied with rehabilitation counseling as their profession completed an experimental version of the SII. Based on these data,…

A novel infrared small moving target detection method based on tracking interest points under complicated background

NASA Astrophysics Data System (ADS)

Dong, Xiabin; Huang, Xinsheng; Zheng, Yongbin; Bai, Shengjian; Xu, Wanying

2014-07-01

Infrared moving target detection is an important part of infrared technology. We introduce a novel infrared small moving target detection method based on tracking interest points under complicated background. Firstly, Difference of Gaussians (DOG) filters are used to detect a group of interest points (including the moving targets). Secondly, a sort of small targets tracking method inspired by Human Visual System (HVS) is used to track these interest points for several frames, and then the correlations between interest points in the first frame and the last frame are obtained. Last, a new clustering method named as R-means is proposed to divide these interest points into two groups according to the correlations, one is target points and another is background points. In experimental results, the target-to-clutter ratio (TCR) and the receiver operating characteristics (ROC) curves are computed experimentally to compare the performances of the proposed method and other five sophisticated methods. From the results, the proposed method shows a better discrimination of targets and clutters and has a lower false alarm rate than the existing moving target detection methods.

Cellulose Nanocrystal Templated Graphene Nanoscrolls for High Performance Supercapacitors and Hydrogen Storage: An Experimental and Molecular Simulation Study.

PubMed

Dhar, Prodyut; Gaur, Surendra Singh; Kumar, Amit; Katiyar, Vimal

2018-03-01

Graphene nanoscrolls (GNS), due to their remarkably interesting properties, have attracted significant interest with applications in various engineering sectors. However, uncontrolled morphologies, poor yield and low quality GNS produced through traditional routes are major challenges associated. We demonstrate sustainable approach of utilizing bio-derived cellulose nanocrystals (CNCs) as template for fabrication of GNS with tunable morphological dimensions ranging from micron-to-nanoscale(controlled length < 1 μm or >1 μm), alongwith encapsulation of catalytically active metallic-species in scroll interlayers. The surface-modified magnetic CNCs acts as structural-directing agents which provides enough momentum to initiate self-scrolling phenomenon of graphene through van der Waals forces and π-π interactions, mechanism of which is demonstrated through experimental and molecular simulation studies. The proposed approach of GNS fabrication provides flexibility to tune physico-chemical properties of GNS by simply varying interlayer spacing, scrolling density and fraction of encapsulated metallic nanoparticles. The hybrid GNS with confined palladium or platinum nanoparticles (at lower loading ~1 wt.%) shows enhanced hydrogen storage capacity (~0.2 wt.% at~20 bar and ~273 K) and excellent supercapacitance behavior (~223-357 F/g) for prolonged cycles (retention ~93.5-96.4% at ~10000 cycles). The current strategy of utilizing bio-based templates can be further extended to incorporate complex architectures or nanomaterials in GNS core or inter-layers, which will potentially broaden its applications in fabrication of high-performance devices.

Big Bang 6Li nucleosynthesis studied deep underground (LUNA collaboration)

NASA Astrophysics Data System (ADS)

Trezzi, D.; Anders, M.; Aliotta, M.; Bellini, A.; Bemmerer, D.; Boeltzig, A.; Broggini, C.; Bruno, C. G.; Caciolli, A.; Cavanna, F.; Corvisiero, P.; Costantini, H.; Davinson, T.; Depalo, R.; Elekes, Z.; Erhard, M.; Ferraro, F.; Formicola, A.; Fülop, Zs.; Gervino, G.; Guglielmetti, A.; Gustavino, C.; Gyürky, Gy.; Junker, M.; Lemut, A.; Marta, M.; Mazzocchi, C.; Menegazzo, R.; Mossa, V.; Pantaleo, F.; Prati, P.; Rossi Alvarez, C.; Scott, D. A.; Somorjai, E.; Straniero, O.; Szücs, T.; Takacs, M.

2017-03-01

The correct prediction of the abundances of the light nuclides produced during the epoch of Big Bang Nucleosynthesis (BBN) is one of the main topics of modern cosmology. For many of the nuclear reactions that are relevant for this epoch, direct experimental cross section data are available, ushering the so-called "age of precision". The present work addresses an exception to this current status: the 2H(α,γ)6Li reaction that controls 6Li production in the Big Bang. Recent controversial observations of 6Li in metal-poor stars have heightened the interest in understanding primordial 6Li production. If confirmed, these observations would lead to a second cosmological lithium problem, in addition to the well-known 7Li problem. In the present work, the direct experimental cross section data on 2H(α,γ)6Li in the BBN energy range are reported. The measurement has been performed deep underground at the LUNA (Laboratory for Underground Nuclear Astrophysics) 400 kV accelerator in the Laboratori Nazionali del Gran Sasso, Italy. The cross section has been directly measured at the energies of interest for Big Bang Nucleosynthesis for the first time, at Ecm = 80, 93, 120, and 133 keV. Based on the new data, the 2H(α,γ)6Li thermonuclear reaction rate has been derived. Our rate is even lower than previously reported, thus increasing the discrepancy between predicted Big Bang 6Li abundance and the amount of primordial 6Li inferred from observations.

Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection.

PubMed

Oseso, Linda; Magaret, Amalia S; Jerome, Keith R; Fox, Julie; Wald, Anna

2016-09-01

Current treatment of genital herpes is focused on ameliorating signs and symptoms but is not curative. However, as potential herpes simplex virus (HSV) cure approaches are tested in the laboratory, we aimed to assess the interest in such studies by persons with genital herpes and the willingness to assume risks associated with experimental therapy. We constructed an anonymous online questionnaire that was posted on websites that provide information regarding genital herpes. The questions collected demographic and clinical information on adults who self-reported as having genital herpes, and assessed attitudes toward and willingness to participate in HSV cure clinical research. Seven hundred eleven participants provided sufficient responses to be included in the analysis. Sixty-six percent were women; the median age was 37 years, and the median time since genital HSV diagnosis was 4.7 years. The willingness to participate in trials increased from 59.0% in phase 1 to 68.5% in phase 2, and 81.2% in phase 3 trials, and 40% reported willingness to participate even in the absence of immediate, personal benefits. The most desirable outcome was the elimination of risk for transmission to sex partner or neonate. The mean perceived severity of receiving a diagnosis of genital HSV-2 was 4.2 on a scale of 1 to 5. Despite suppressive therapy available, persons with genital herpes are interested in participating in clinical research aimed at curing HSV, especially in more advanced stages of development.

Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection

PubMed Central

Oseso, Linda; Magaret, Amalia S; Jerome, Keith R; Fox, Julie; Wald, Anna

2016-01-01

Background Current treatment of genital herpes is focused on ameliorating signs and symptoms but is not curative. However, as potential HSV cure approaches are tested in the laboratory, we aimed to assess the interest in such studies by persons with genital herpes, and the willingness to assume risks associated with experimental therapy. Methods We constructed an anonymous online questionnaire that was posted on websites that provide information regarding genital herpes. The questions collected demographic and clinical information on adults who self-reported as having genital herpes, and assessed attitudes toward and willingness to participate in HSV cure clinical research. Results 711 participants provided sufficient responses to be included in the analysis. 66% were women; the median age was 37 years, and the median time since genital HSV diagnosis was 4.7 years. The willingness to participate in trials increased from 59.0% in Phase 1 to 68.5% in Phase 2 and 81.2% in Phase 3 trials, and 40% reported willingness to participate even in the absence of immediate, personal benefits. The most desirable outcome was the elimination of risk for transmission to sex partner or neonate. The mean perceived severity of receiving a diagnosis of genital HSV-2 was 4.2 on a scale of 1 to 5. Conclusions Despite suppressive therapy available, persons with genital herpes are interested in participating in clinical research aimed at curing HSV, especially in more advanced stages of development. PMID:27513383

Continuous and embedded solutions for SHM of concrete structures using changing electrical potential in self-sensing cement-based composites

NASA Astrophysics Data System (ADS)

Downey, Austin; Garcia-Macias, Enrique; D'Alessandro, Antonella; Laflamme, Simon; Castro-Triguero, Rafael; Ubertini, Filippo

2017-04-01

Interest in the concept of self-sensing structural materials has grown in recent years due to its potential to enable continuous low-cost monitoring of next-generation smart-structures. The development of cement-based smart sensors appears particularly well suited for monitoring applications due to their numerous possible field applications, their ease of use and long-term stability. Additionally, cement-based sensors offer a unique opportunity for structural health monitoring of civil structures because of their compatibility with new or existing infrastructure. Particularly, the addition of conductive carbon nanofillers into a cementitious matrix provides a self-sensing structural material with piezoresistive characteristics sensitive to deformations. The strain-sensing ability is achieved by correlating the external loads with the variation of specific electrical parameters, such as the electrical resistance or impedance. Selection of the correct electrical parameter for measurement to correlate with features of interest is required for the condition assessment task. In this paper, we investigate the potential of using altering electrical potential in cement-based materials doped with carbon nanotubes to measure strain and detect damage in concrete structures. Experimental validation is conducted on small-scale specimens including a steel-reinforced beam of conductive cement paste. Comparisons are made with constant electrical potential and current methods commonly found in the literature. Experimental results demonstrate the ability of the changing electrical potential at detecting features important for assessing the condition of a structure.

Energy Migration in Organic Thin Films--From Excitons to Polarons

NASA Astrophysics Data System (ADS)

Mullenbach, Tyler K.

The rise of organic photovoltaic devices (OPVs) and organic light-emitting devices has generated interest in the physics governing exciton and polaron dynamics in thin films. Energy transfer has been well studied in dilute solutions, but there are emergent properties in thin films and greater complications due to complex morphologies which must be better understood. Despite the intense interest in energy transport in thin films, experimental limitations have slowed discoveries. Here, a new perspective of OPV operation is presented where photovoltage, instead of photocurrent, plays the fundamental role. By exploiting this new vantage point the first method of measuring the diffusion length (LD) of dark (non-luminescent) excitons is developed, a novel photodetector is invented, and the ability to watch exciton arrival, in real-time, at the donor-acceptor heterojunction is presented. Using an enhanced understanding of exciton migration in thin films, paradigms for enhancing LD by molecular modifications are discovered, and the first exciton gate is experimentally and theoretically demonstrated. Generation of polarons from exciton dissociation represents a second phase of energy migration in OPVs that remains understudied. Current approaches are capable of measuring the rate of charge carrier recombination only at open-circuit. To enable a better understanding of polaron dynamics in thin films, two new approaches are presented which are capable of measuring both the charge carrier recombination and transit rates at any OPV operating voltage. These techniques pave the way for a more complete understanding of charge carrier kinetics in molecular thin films.

The Quest for Value-Added Products from Carbon Dioxide and Water in a Dielectric Barrier Discharge: A Chemical Kinetics Study.

PubMed

Snoeckx, Ramses; Ozkan, Alp; Reniers, Francois; Bogaerts, Annemie

2017-01-20

Recycling of carbon dioxide by its conversion into value-added products has gained significant interest owing to the role it can play for use in an anthropogenic carbon cycle. The combined conversion with H 2 O could even mimic the natural photosynthesis process. An interesting gas conversion technique currently being considered in the field of CO 2 conversion is plasma technology. To investigate whether it is also promising for this combined conversion, we performed a series of experiments and developed a chemical kinetics plasma chemistry model for a deeper understanding of the process. The main products formed were the syngas components CO and H 2 , as well as O 2 and H 2 O 2 , whereas methanol formation was only observed in the parts-per-billion to parts-per-million range. The syngas ratio, on the other hand, could easily be controlled by varying both the water content and/or energy input. On the basis of the model, which was validated with experimental results, a chemical kinetics analysis was performed, which allowed the construction and investigation of the different pathways leading to the observed experimental results and which helped to clarify these results. This approach allowed us to evaluate this technology on the basis of its underlying chemistry and to propose solutions on how to further improve the formation of value-added products by using plasma technology. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Evaluation of analgesic activity of Terminalia arjuna (Roxb.) Wight and Arn bark: A tribal claim.

PubMed

Gupta, Anurag; Nishteswar, K; Shukla, Vinay J; Ashok, B K

2014-01-01

Plants occupy an important place in folk medicine all over the world for centuries and indigenous communities have developed their own specific knowledge on plant resources, uses, management, and conservation. Research interest and activities in the area of ethno medicine have increased tremendously in the last decade. Currently, scientists are evincing keen interest in the scientific evaluation of ethno medical claims. Bark powder of Arjuna (Terminalia arjuna [Roxb.] Wight and Arn) is used by tribals for the management of some painful conditions. To evaluate analgesic activity of T. arjuna bark in rodents. For evaluation of analgesic activity, different experimental models, that is, the acetic acid-induced writhing syndrome in mice, formaldehyde-induced paw licking response and tail flick test in rats were designed. Experiments were carried out at two-dose levels, that is, therapeutically equivalent dose (TED) and TED × 2. Animals were divided into three groups (six animals in each group), first group serving as a control group, second and third group labeled as test drug group. Test drug at both the doses significantly decreased the writhing syndrome in comparison to control the group. In comparison to control the group, incidences of formalin-induced paw licking were reduced in test drug groups in both early and late phases of pain. In tail flick response, threshold was significantly increased in both test drug groups at every time intervals. Study showed that stem bark of T. arjuna possesses analgesic activity in all experimental models.

Translational pain assessment: could natural animal models be the missing link?

PubMed

Klinck, Mary P; Mogil, Jeffrey S; Moreau, Maxim; Lascelles, B Duncan X; Flecknell, Paul A; Poitte, Thierry; Troncy, Eric

2017-09-01

Failure of analgesic drugs in clinical development is common. Along with the current "reproducibility crisis" in pain research, this has led some to question the use of animal models. Experimental models tend to comprise genetically homogeneous groups of young, male rodents in restricted and unvarying environments, and pain-producing assays that may not closely mimic the natural condition of interest. In addition, typical experimental outcome measures using thresholds or latencies for withdrawal may not adequately reflect clinical pain phenomena pertinent to human patients. It has been suggested that naturally occurring disease in veterinary patients may provide more valid models for the study of painful disease. Many painful conditions in animals resemble those in people. Like humans, veterinary patients are genetically diverse, often live to old age, and enjoy a complex environment, often the same as their owners. There is increasing interest in the development and validation of outcome measures for detecting pain in veterinary patients; these include objective (eg, locomotor activity monitoring, kinetic evaluation, quantitative sensory testing, and bioimaging) and subjective (eg, pain scales and quality of life scales) measures. Veterinary subject diversity, pathophysiological similarities to humans, and diverse outcome measures could yield better generalizability of findings and improved translation potential, potentially benefiting both humans and animals. The Comparative Oncology Trial Consortium in dogs has pawed the way for translational research, surmounting the challenges inherent in veterinary clinical trials. This review describes numerous conditions similarly applicable to pain research, with potential mutual benefits for human and veterinary clinicians, and their respective patients.

Flooding Experiments and Modeling for Improved Reactor Safety

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solmos, M.; Hogan, K. J.; Vierow, K.

2008-09-14

Countercurrent two-phase flow and “flooding” phenomena in light water reactor systems are being investigated experimentally and analytically to improve reactor safety of current and future reactors. The aspects that will be better clarified are the effects of condensation and tube inclination on flooding in large diameter tubes. The current project aims to improve the level of understanding of flooding mechanisms and to develop an analysis model for more accurate evaluations of flooding in the pressurizer surge line of a Pressurized Water Reactor (PWR). Interest in flooding has recently increased because Countercurrent Flow Limitation (CCFL) in the AP600 pressurizer surge linemore » can affect the vessel refill rate following a small break LOCA and because analysis of hypothetical severe accidents with the current flooding models in reactor safety codes shows that these models represent the largest uncertainty in analysis of steam generator tube creep rupture. During a hypothetical station blackout without auxiliary feedwater recovery, should the hot leg become voided, the pressurizer liquid will drain to the hot leg and flooding may occur in the surge line. The flooding model heavily influences the pressurizer emptying rate and the potential for surge line structural failure due to overheating and creep rupture. The air-water test results in vertical tubes are presented in this paper along with a semi-empirical correlation for the onset of flooding. The unique aspects of the study include careful experimentation on large-diameter tubes and an integrated program in which air-water testing provides benchmark knowledge and visualization data from which to conduct steam-water testing.« less

Understanding Molecular Conduction: Old Wine in a New Bottle?

NASA Astrophysics Data System (ADS)

Ghosh, Avik

2007-03-01

Molecules provide an opportunity to test our understanding of fundamental non-equilibrium transport processes, as well as explore new device possibilities. We have developed a unified approach to nanoscale conduction, coupling bandstructure and electrostatics of the channel and contacts with a quantum kinetic theory of current flow. This allows us to describe molecular conduction at various levels of detail, -- from quantum corrected compact models, to semi-empirical models for quick physical insights, and `first-principles' calculations of current-voltage (I-V) characteristics with no adjustable parameters. Using this suite of tools, we can quantitatively explain various experimental I-Vs, including complex reconstructed silicon substrates. We find that conduction in most molecules is contact dominated, and limited by fundamental electrostatic and thermodynamic restrictions quite analogous to those faced by the silicon industry, barring a few interesting exceptions. The distinction between molecular and silicon electronics must therefore be probed at a more fundamental level. Ultra-short molecules are unique in that they possess large Coulomb energies as well as anomalous vibronic couplings with current flow -- in other words, strong non-equilibrium electron-electron and electron-phonon correlations. These effects yield prominent experimental signatures, but require a completely different modeling approach -- in fact, popular approaches to include correlation typically do not work for non-equilibrium. Molecules exhibit rich physics, including the ability to function both as weakly interacting current conduits (quantum wires) as well as strongly correlated charge storage centers (quantum dots). Theoretical treatment of the intermediate coupling regime is particularly challenging, with a large `fine structure constant' for transport that negates orthodox theories of Coulomb Blockade and phonon-assisted tunneling. It is in this regime that the scientific and technological merits of molecular conductors may need to be explored. For instance, the tunable quantum coupling of current flow in silicon transistors with engineered molecular scatterers could lead to devices that operate on completely novel principles.

Feature Tracking for High Speed AFM Imaging of Biopolymers.

PubMed

Hartman, Brett; Andersson, Sean B

2018-03-31

The scanning speed of atomic force microscopes continues to advance with some current commercial microscopes achieving on the order of one frame per second and at least one reaching 10 frames per second. Despite the success of these instruments, even higher frame rates are needed with scan ranges larger than are currently achievable. Moreover, there is a significant installed base of slower instruments that would benefit from algorithmic approaches to increasing their frame rate without requiring significant hardware modifications. In this paper, we present an experimental demonstration of high speed scanning on an existing, non-high speed instrument, through the use of a feedback-based, feature-tracking algorithm that reduces imaging time by focusing on features of interest to reduce the total imaging area. Experiments on both circular and square gratings, as well as silicon steps and DNA strands show a reduction in imaging time by a factor of 3-12 over raster scanning, depending on the parameters chosen.

Scaling laws for positron production in laser-electron beam collisions

NASA Astrophysics Data System (ADS)

Blackburn, Tom; Ilderton, Anton; Murphy, Christopher; Marklund, Mattias

2017-10-01

Showers of gamma rays and positrons are produced when a multi-GeV electron beam collides with a super-intense laser pulse. All-optical realisation of this geometry, where the electron beam is generated by laser-wakefield acceleration, is currently attracting much experimental interest as a probe of radiation reaction and QED effects. These interactions may be modelled theoretically in the framework of strong-field QED or numerically by large-scale PIC simulation. To complement these, we present analytical scaling laws for the electron beam energy loss, gamma ray spectrum, and the positron yield and energy that are valid in the radiation-reaction-dominated regime. These indicate that by employing the collision of a 2 GeV electron beam with a laser pulse of intensity 5 ×1021Wcm-2 , it is possible to produce 10,000 positrons in a single shot at currently available laser facilities. The authors acknowledge support from the Knut and Alice Wallenberg Foundation.

Phage phenomics: Physiological approaches to characterize novel viral proteins

ScienceCinema

Sanchez, Savannah E. [San Diego State Univ., San Diego, CA (United States); Cuevas, Daniel A. [San Diego State Univ., San Diego, CA (United States); Rostron, Jason E. [San Diego State Univ., San Diego, CA (United States); Liang, Tiffany Y. [San Diego State Univ., San Diego, CA (United States); Pivaroff, Cullen G. [San Diego State Univ., San Diego, CA (United States); Haynes, Matthew R. [San Diego State Univ., San Diego, CA (United States); Nulton, Jim [San Diego State Univ., San Diego, CA (United States); Felts, Ben [San Diego State Univ., San Diego, CA (United States); Bailey, Barbara A. [San Diego State Univ., San Diego, CA (United States); Salamon, Peter [San Diego State Univ., San Diego, CA (United States); Edwards, Robert A. [San Diego State Univ., San Diego, CA (United States); Argonne National Lab. (ANL), Argonne, IL (United States); Burgin, Alex B. [Broad Institute, Cambridge, MA (United States); Segall, Anca M. [San Diego State Univ., San Diego, CA (United States); Rohwer, Forest [San Diego State Univ., San Diego, CA (United States)

2018-06-21

Current investigations into phage-host interactions are dependent on extrapolating knowledge from (meta)genomes. Interestingly, 60 - 95% of all phage sequences share no homology to current annotated proteins. As a result, a large proportion of phage genes are annotated as hypothetical. This reality heavily affects the annotation of both structural and auxiliary metabolic genes. Here we present phenomic methods designed to capture the physiological response(s) of a selected host during expression of one of these unknown phage genes. Multi-phenotype Assay Plates (MAPs) are used to monitor the diversity of host substrate utilization and subsequent biomass formation, while metabolomics provides bi-product analysis by monitoring metabolite abundance and diversity. Both tools are used simultaneously to provide a phenotypic profile associated with expression of a single putative phage open reading frame (ORF). Thus, representative results for both methods are compared, highlighting the phenotypic profile differences of a host carrying either putative structural or metabolic phage genes. In addition, the visualization techniques and high throughput computational pipelines that facilitated experimental analysis are presented.

Certification Strategies using Run-Time Safety Assurance for Part 23 Autopilot Systems

NASA Technical Reports Server (NTRS)

Hook, Loyd R.; Clark, Matthew; Sizoo, David; Skoog, Mark A.; Brady, James

2016-01-01

Part 23 aircraft operation, and in particular general aviation, is relatively unsafe when compared to other common forms of vehicle travel. Currently, there exists technologies that could increase safety statistics for these aircraft; however, the high burden and cost of performing the requisite safety critical certification processes for these systems limits their proliferation. For this reason, many entities, including the Federal Aviation Administration, NASA, and the US Air Force, are considering new options for certification for technologies that will improve aircraft safety. Of particular interest, are low cost autopilot systems for general aviation aircraft, as these systems have the potential to positively and significantly affect safety statistics. This paper proposes new systems and techniques, leveraging run-time verification, for the assurance of general aviation autopilot systems, which would be used to supplement the current certification process and provide a viable path for near-term low-cost implementation. In addition, discussions on preliminary experimentation and building the assurance case for a system, based on these principles, is provided.

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

PubMed Central

Mora, Ana L.; Rojas, Mauricio; Pardo, Annie; Selman, Moises

2018-01-01

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely understood and current therapies are limited to those that reduce the rate of functional decline in patients with mild-to-moderate disease. In this context, new therapeutic approaches that substantially improve the survival time and quality of life of these patients are urgently needed. Our incomplete understanding of the pathogenic mechanisms of IPF and the lack of appropriate experimental models that reproduce the key characteristics of the human disease are major challenges. As ageing is a major risk factor for IPF, age-related cell perturbations such as telomere attrition, senescence, epigenetic drift, stem cell exhaustion, loss of proteostasis and mitochondrial dysfunction are becoming targets of interest for IPF therapy. In this Review, we discuss current and emerging therapies for IPF, particularly those targeting age-related mechanisms, and discuss future therapeutic approaches. PMID:29081515

Application of RANS Simulations for Contact Time Predictions in Turbulent Reactor Tanks for Water Purification Process

NASA Astrophysics Data System (ADS)

Nickles, Cassandra; Goodman, Matthew; Saez, Jose; Issakhanian, Emin

2016-11-01

California's current drought has renewed public interest in recycled water from Water Reclamation Plants (WRPs). It is critical that the recycled water meets public health standards. This project consists of simulating the transport of an instantaneous conservative tracer through the WRP chlorine contact tanks. Local recycled water regulations stipulate a minimum 90-minute modal contact time during disinfection at peak dry weather design flow. In-situ testing is extremely difficult given flowrate dependence on real world sewage line supply and recycled water demand. Given as-built drawings and operation parameters, the chlorine contact tanks are modeled to simulate extreme situations, which may not meet regulatory standards. The turbulent flow solutions are used as the basis to model the transport of a turbulently diffusing conservative tracer added instantaneously to the inlet of the reactors. This tracer simulates the transport through advection and dispersion of chlorine in the WRPs. Previous work validated the models against experimental data. The current work shows the predictive value of the simulations.

Sodium-Oxygen Battery: Steps Toward Reality.

PubMed

Landa-Medrano, Imanol; Li, Chunmei; Ortiz-Vitoriano, Nagore; Ruiz de Larramendi, Idoia; Carrasco, Javier; Rojo, Teófilo

2016-04-07

Rechargeable metal-oxygen batteries are receiving significant interest as a possible alternative to current state of the art lithium ion batteries due to their potential to provide higher gravimetric energies, giving significantly lighter or longer-lasting batteries. Recent advances suggest that the Na-O2 battery, in many ways analogous to Li-O2 yet based on the reversible formation of sodium superoxide (NaO2), has many advantages such as a low charge overpotential (∼100 mV) resulting in improved efficiency. In this Perspective, we discuss the current state of knowledge in Na-O2 battery technology, with an emphasis on the latest experimental studies, as well as theoretical models. We offer special focus on the principle outstanding challenges and issues and address the advantages/disadvantages of the technology when compared with Li-O2 batteries as well as other state-of-the-art battery technologies. We finish by detailing the direction required to make Na-O2 batteries both commercially and technologically viable.

Atomic-Monolayer Two-Dimensional Lateral Quasi-Heterojunction Bipolar Transistors with Resonant Tunneling Phenomenon.

PubMed

Lin, Che-Yu; Zhu, Xiaodan; Tsai, Shin-Hung; Tsai, Shiao-Po; Lei, Sidong; Shi, Yumeng; Li, Lain-Jong; Huang, Shyh-Jer; Wu, Wen-Fa; Yeh, Wen-Kuan; Su, Yan-Kuin; Wang, Kang L; Lan, Yann-Wen

2017-11-28

High-frequency operation with ultrathin, lightweight, and extremely flexible semiconducting electronics is highly desirable for the development of mobile devices, wearable electronic systems, and defense technologies. In this work, the experimental observation of quasi-heterojunction bipolar transistors utilizing a monolayer of the lateral WSe 2 -MoS 2 junctions as the conducting p-n channel is demonstrated. Both lateral n-p-n and p-n-p heterojunction bipolar transistors are fabricated to exhibit the output characteristics and current gain. A maximum common-emitter current gain of around 3 is obtained in our prototype two-dimensional quasi-heterojunction bipolar transistors. Interestingly, we also observe the negative differential resistance in the electrical characteristics. A potential mechanism is that the negative differential resistance is induced by resonant tunneling phenomenon due to the formation of quantum well under applying high bias voltages. Our results open the door to two-dimensional materials for high-frequency, high-speed, high-density, and flexible electronics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanchez, Savannah E.; Cuevas, Daniel A.; Rostron, Jason E.

Current investigations into phage-host interactions are dependent on extrapolating knowledge from (meta)genomes. Interestingly, 60 - 95% of all phage sequences share no homology to current annotated proteins. As a result, a large proportion of phage genes are annotated as hypothetical. This reality heavily affects the annotation of both structural and auxiliary metabolic genes. Here we present phenomic methods designed to capture the physiological response(s) of a selected host during expression of one of these unknown phage genes. Multi-phenotype Assay Plates (MAPs) are used to monitor the diversity of host substrate utilization and subsequent biomass formation, while metabolomics provides bi-product analysismore » by monitoring metabolite abundance and diversity. Both tools are used simultaneously to provide a phenotypic profile associated with expression of a single putative phage open reading frame (ORF). Thus, representative results for both methods are compared, highlighting the phenotypic profile differences of a host carrying either putative structural or metabolic phage genes. In addition, the visualization techniques and high throughput computational pipelines that facilitated experimental analysis are presented.« less

A Review of Out-of-School Time Program Quasi-Experimental and Experimental Evaluation Results. Out-of-School Time Evaluation Snapshot.

ERIC Educational Resources Information Center

Little, Priscilla M. D.; Harris, Erin

As the amount of resources allocated to out-of-school (OST) programming and policymakers' demands for research-based results increase, there is increasing interest in rigorous research designs to examine OST program outcomes. This issue of "Out-of-School Time Evaluation Snapshots" reviews 27 quasi-experimental and experimental OST…

Advanced Communications Technology Satellite (ACTS). Phase 1: Industrial/academic experimenters

NASA Technical Reports Server (NTRS)

Maisel, James E.; Nowlin, Robert W.

1992-01-01

This report presents the work done at Arizona State University under the ACTS Experimenters Program. The main thrust of the Program was to develop experiments to test, evaluate, and prove the commercial worthiness of the ACTS satellite which is scheduled for launch in 1993. To accomplish this goal, meetings were held with various governmental, industrial, and academic units to discuss the ACTS satellite and its technology and possible experiments that would generate industrial interest and support for ASU's efforts. Several local industries generated several experiments of their own. The investigators submitted several experiments of educational, medical, commercial, and technical value and interest. The disposition of these experimental proposals is discussed in this report.

Magnon-based logic in a multi-terminal YIG/Pt nanostructure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ganzhorn, Kathrin, E-mail: kathrin.ganzhorn@wmi.badw.de; Klingler, Stefan; Wimmer, Tobias

2016-07-11

Boolean logic is the foundation of modern digital information processing. Recently, there has been a growing interest in phenomena based on pure spin currents, which allows to move from charge to spin based logic gates. We study a proof-of-principle logic device based on the ferrimagnetic insulator Yttrium Iron Garnet, with Pt strips acting as injectors and detectors for non-equilibrium magnons. We experimentally observe incoherent superposition of magnons generated by different injectors. This allows to implement a fully functional majority gate, enabling multiple logic operations (AND and OR) in one and the same device. Clocking frequencies of the order of severalmore » GHz and straightforward down-scaling make our device promising for applications.« less

Thermodynamic Assessment of the Y2o3-yb2o3-zro2 System

NASA Technical Reports Server (NTRS)

Jacobson, Nathan S.; Liu, Zi-Kui; Kaufman, Larry; Zhang, Fan

2002-01-01

Yttria-zirconia (Y2O3-ZrO2) is the most widely used of the rare earth oxide-zirconia systems. There are numerous experimental studies of the phase boundaries in this system. In this paper, we assess these data and derive parameters for the solution models in this system. There is current interest in other rare earth oxide-zirconia systems as well as systems with several rare earth oxides and zirconia, which may offer improved properties over the Y2O3-ZrO2 system. For this reason, we also assess the ytterbia-zirconia (Yb2O3-ZrO2) and Y2O3-Yb2O3-ZrO2 system.

Energetics of Single Substitutional Impurities in NiTi

NASA Technical Reports Server (NTRS)

Good, Brian S.; Noebe, Ronald

2003-01-01

Shape-memory alloys are of considerable current interest, with applications ranging from stents to Mars rover components. In this work, we present results on the energetics of single substitutional impurities in B2 NiTi. Specifically, energies of Pd, Pt, Zr and Hf impurities at both Ni and Ti sites are computed. All energies are computed using the CASTEP ab initio code, and, for comparison, using the quantum approximate energy method of Bozzolo, Ferrante and Smith. Atomistic relaxation in the vicinity of the impurities is investigated via quantum approximate Monte Carlo simulation, and in cases where the relaxation is found to be important, the resulting relaxations are applied to the ab initio calculations. We compare our results with available experimental work.

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garbil, Roger

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden). Workshop Organizing Committee: Enrico Chiaveri (Chairman); Marco Calviani; Samuel Andriamonje; Eric Berthoumieux; Carlos Guerrero; Robertomore » Losito; Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, J.N.

2010-11-09

Part 7 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities;International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman) Marco Calvianimore » Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean.« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lantz, Mattias; Neudecker, Denise

2010-11-09

Part 5 of The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium) A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuelmore » Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vlachoudis, Vasilis

2010-11-09

Part 8. The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu Topics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Ericmore » Berthoumieux Carlos Guerrero Roberto LositoVasilis Vlachoudis Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.eu. Topics of interest include: Data evaluation; Cross section measurements; Experimental techniques; Uncertainties and covariances; Fission properties; Current and future facilities. International Advisory Committee: C. Barreau (CENBG, France) T. Belgya (IKI KFKI, Hungary) E. Gonzalez (CIEMAT, Spain) F. Gunsing (CEA, France) F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany) R. Nolte (PTB, Germany) S. Pomp (TSL UU, Sweden) & Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuelmore » Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Losito Vasilis Vlachoudis; Workshop Assistant: Geraldine Jean« less

Final Scientific EFNUDAT Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-11-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive. EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluation Cross section measurements Experimental techniques Uncertainties and covariances Fission properties Current and future facilities ; International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) ;Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco Calviani Samuel Andriamonje Eric Berthoumieux Carlos Guerrero Roberto Lositomore » Vasilis Vlachoudis;Workshop Assistant: Geraldine Jean« less

The PMDB Protein Model Database

PubMed Central

Castrignanò, Tiziana; De Meo, Paolo D'Onorio; Cozzetto, Domenico; Talamo, Ivano Giuseppe; Tramontano, Anna

2006-01-01

The Protein Model Database (PMDB) is a public resource aimed at storing manually built 3D models of proteins. The database is designed to provide access to models published in the scientific literature, together with validating experimental data. It is a relational database and it currently contains >74 000 models for ∼240 proteins. The system is accessible at and allows predictors to submit models along with related supporting evidence and users to download them through a simple and intuitive interface. Users can navigate in the database and retrieve models referring to the same target protein or to different regions of the same protein. Each model is assigned a unique identifier that allows interested users to directly access the data. PMID:16381873

Final Scientific EFNUDAT Workshop

ScienceCinema

None

2017-12-09

The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluationCross section measurementsExperimental techniquesUncertainties and covariancesFission propertiesCurrent and future facilities  International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco CalvianiSamuel AndriamonjeEric BerthoumieuxCarlos GuerreroRoberto LositoVasilis Vlachoudis Workshop Assistant: Géraldine Jean

Spectral and spatial characterisation of laser-driven positron beams

DOE PAGES

Sarri, G.; Warwick, J.; Schumaker, W.; ...

2016-10-18

The generation of high-quality relativistic positron beams is a central area of research in experimental physics, due to their potential relevance in a wide range of scientific and engineering areas, ranging from fundamental science to practical applications. There is now growing interest in developing hybrid machines that will combine plasma-based acceleration techniques with more conventional radio-frequency accelerators, in order to minimise the size and cost of these machines. Here we report on recent experiments on laser-driven generation of high-quality positron beams using a relatively low energy and potentially table-top laser system. Lastly, the results obtained indicate that current technology allowsmore » to create, in a compact setup, positron beams suitable for injection in radio-frequency accelerators.« less

Femtosecond laser cataract surgery: technology and clinical practice.

PubMed

Roberts, Timothy V; Lawless, Michael; Chan, Colin Ck; Jacobs, Mark; Ng, David; Bali, Shveta J; Hodge, Chris; Sutton, Gerard

2013-03-01

The recent introduction of femtosecond lasers to cataract surgery has generated much interest among ophthalmologists around the world. Laser cataract surgery integrates high-resolution anterior segment imaging systems with a femtosecond laser, allowing key steps of the procedure, including the primary and side-port corneal incisions, the anterior capsulotomy and fragmentation of the lens nucleus, to be performed with computer-guided laser precision. There is emerging evidence of reduced phacoemulsification time, better wound architecture and a more stable refractive result with femtosecond cataract surgery, as well as reports documenting an initial learning curve. This article will review the current state of technology and discuss our clinical experience. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.

Subradiant spontaneous undulator emission through collective suppression of shot noise

DOE PAGES

Ratner, D.; Hemsing, E.; Gover, A.; ...

2015-05-01

The phenomenon of Dicke’s subradiance, in which the collective properties of a system suppress radiation, has received broad interest in atomic physics. Recent theoretical papers in the field of relativistic electron beams have proposed schemes to achieve subradiance through suppression of shot noise current fluctuations. The resulting “quiet” beam generates less spontaneous radiation than emitted even by a shot noise beam when oscillating in an undulator. Quiet beams could have diverse accelerator applications, including lowering power requirements for seeded free-electron lasers and improving efficiency of hadron cooling. In this paper we present experimental observation of a strong reduction in undulatormore » radiation, demonstrating the feasibility of noise suppression as a practical tool in accelerator physics.« less

Thermal stress in dentin and enamel under CO2 laser irradiation

NASA Astrophysics Data System (ADS)

Meyer, Dirk H.; Foth, Hans-Jochen

1996-01-01

Ablation of dentin and tartar was studied under carbon dioxide-laser irradiation in cw and pulse mode with pulse length down to 150 microseconds. The specimens had been cut by a diamant blade to slices of thicknesses between 0.8 and 2.8 mm. The laser induced temperature rise was measured by an infrared camera monitoring the backside of the samples. The specimens shape and structure at the laser spot was analyzed by electron microscopy. Of special interest was the testing of the SwiftLaseTM to reducing the heat. The experimental results show the necessity of a water cooling in all application modes. The origin of the cracks which had been observed in many of the samples, is currently under investigation.

Conceptual information processing: A robust approach to KBS-DBMS integration

NASA Technical Reports Server (NTRS)

Lazzara, Allen V.; Tepfenhart, William; White, Richard C.; Liuzzi, Raymond

1987-01-01

Integrating the respective functionality and architectural features of knowledge base and data base management systems is a topic of considerable interest. Several aspects of this topic and associated issues are addressed. The significance of integration and the problems associated with accomplishing that integration are discussed. The shortcomings of current approaches to integration and the need to fuse the capabilities of both knowledge base and data base management systems motivates the investigation of information processing paradigms. One such paradigm is concept based processing, i.e., processing based on concepts and conceptual relations. An approach to robust knowledge and data base system integration is discussed by addressing progress made in the development of an experimental model for conceptual information processing.

Proton irradiation of simple gas mixtures: Influence of irradiation parameters

NASA Technical Reports Server (NTRS)

Sack, Norbert J.; Schuster, R.; Hofmann, A.

1990-01-01

In order to get information about the influence of irradiation parameters on radiolysis processes of astrophysical interest, methane gas targets were irradiated with 6.5 MeV protons at a pressure of 1 bar and room temperature. Yields of higher hydrocarbons like ethane or propane were found by analysis of irradiated gas samples using gas chromatography. The handling of the proton beam was of great experimental importance for determining the irradiation parameters. In a series of experiments current density of the proton beam and total absorbed energy were shown to have a large influence on the yields of produced hydrocarbons. Mechanistic interpretations of the results are given and conclusions are drawn with regard to the chemistry and the simulation of various astrophysical systems.

Doping Asymmetry Problem in ZnO: Current Status and Outlook. A Review of Experimental and Theoretical Efforts Focused on Achieving P-Type ZnO Suitable for Light-Emitting Optoelectronic Devices for the Blue/Ultraviolet Spectral Range

DTIC Science & Technology

2009-04-24

it seems at a first glance, because the isovalent co- doping of ZnO will result also in an increase of the band gap which usually gives rise to an...J.G. Lu, H.P. He, L.X. Chen, X.Q. Gu, J.Y. Huang, L.P. Zhu, and B.H. Zhao, “Na doping concentration tuned conductivity of ZnO films via pulsed laser...recently as a promising material for a variety of applications. To a large extent, the renewed interest in ZnO is fuelled by its wide direct band gap (3.3

Theory of the Spin Galvanic Effect at Oxide Interfaces

NASA Astrophysics Data System (ADS)

Seibold, Götz; Caprara, Sergio; Grilli, Marco; Raimondi, Roberto

2017-12-01

The spin galvanic effect (SGE) describes the conversion of a nonequilibrium spin polarization into a transverse charge current. Recent experiments have demonstrated a large conversion efficiency for the two-dimensional electron gas formed at the interface between two insulating oxides, LaAlO3 and SrTiO3 . Here, we analyze the SGE for oxide interfaces within a three-band model for the Ti t2 g orbitals which displays an interesting variety of effective spin-orbit couplings in the individual bands that contribute differently to the spin-charge conversion. Our analytical approach is supplemented by a numerical treatment where we also investigate the influence of disorder and temperature, which turns out to be crucial to providing an appropriate description of the experimental data.

Epstein-Barr virus: a paradigm for persistent infection - for real and in virtual reality.

PubMed

Thorley-Lawson, David A; Duca, Karen A; Shapiro, Michael

2008-04-01

The really interesting thing about herpesviruses is that they can establish lifelong persistant infections in immunocompetent hosts. At first glance, they would seem to have very different ways of doing this. Here we will use as a model our current understanding of how the human herpesvirus Epstein-Barr virus establishes and maintains such an infection. We apply information from a wide range of sources including laboratory experimentation, clinical observation, animal models and a new computer simulation. We propose that the detailed mechanisms for establishing infection are dependent on the virus and tissues involved, but the strategy is the same - to persist in a long-lived cell type where the virus is invisible to the immune system and nonpathogenic.

Subradiant spontaneous undulator emission through collective suppression of shot noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, D.; Hemsing, E.; Gover, A.

The phenomenon of Dicke’s subradiance, in which the collective properties of a system suppress radiation, has received broad interest in atomic physics. Recent theoretical papers in the field of relativistic electron beams have proposed schemes to achieve subradiance through suppression of shot noise current fluctuations. The resulting “quiet” beam generates less spontaneous radiation than emitted even by a shot noise beam when oscillating in an undulator. Quiet beams could have diverse accelerator applications, including lowering power requirements for seeded free-electron lasers and improving efficiency of hadron cooling. In this paper we present experimental observation of a strong reduction in undulatormore » radiation, demonstrating the feasibility of noise suppression as a practical tool in accelerator physics.« less

Back to the Basics: Cnidarians Start to Fire

PubMed Central

Bosch, Thomas C. G.; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W.; Jékely, Gáspár; Miller, David J.; Murillo-Rincon, Andrea P.; Rentzsch, Fabian; Richards, Gemma S.; Schröder, Katja; Technau, Ulrich; Yuste, Rafael

2016-01-01

The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to inform us about basic structural and functional principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of some cnidarian species and propose that researchers should seize this opportunity and undertake the study of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. PMID:28041633

Back to the Basics: Cnidarians Start to Fire.

PubMed

Bosch, Thomas C G; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W; Jékely, Gáspár; Miller, David J; Murillo-Rincon, Andrea P; Rentzsch, Fabian; Richards, Gemma S; Schröder, Katja; Technau, Ulrich; Yuste, Rafael

2017-02-01

The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to reveal fundamental principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of cnidarian species and propose that researchers should seize this opportunity and undertake the study of members of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. Copyright © 2016 Elsevier Ltd. All rights reserved.

Is DNA a metal, semiconductor or insulator? A theoretical approach

NASA Astrophysics Data System (ADS)

Rey-Gonzalez, Rafael; Fonseca-Romero, Karen; Plazas, Carlos; Grupo de Óptica e Información Cuántica Team

Over the last years, scientific interest for designing and making low dimensional electronic devices with traditional or novel materials has been increased. These experimental and theoretical researches in electronic properties at molecular scale are looking for developing efficient devices able to carry out tasks which are currently done by silicon transistors and devices. Among the new materials DNA strands are highlighted, but the experimental results have been contradictories pointing to behaviors as conductor, semiconductor or insulator. To contribute to the understanding of the origin of the disparity of the measurements, we perform a numerical calculation of the electrical conductance of DNA segments, modeled as 1D disordered finite chains. The system is described into a Tight binding model with nearest neighbor interactions and a s orbital per site. Hydration effects are included as random variations of self-energies. The electronic current as a function of applied bias is calculated using Launder formalism, where the transmission probability is determined into the transfer matrix formalism. We find a conductor-to-semiconductor-to-insulator transition as a function of the three effects taken into account: chain size, intrinsic disorder, and hydration We thank Fundación para la Promoción de la Investigación y la Tecnología, Colombia, and Dirección de Investigación de Bogotá, Universidad Nacional de Colombia, for partial financial support.

Tuning transport properties of graphene three-terminal structures by mechanical deformation

NASA Astrophysics Data System (ADS)

Torres, V.; Faria, D.; Latgé, A.

2018-04-01

Straintronic devices made of carbon-based materials have been pushed up due to the graphene high mechanical flexibility and the possibility of interesting changes in transport properties. Properly designed strained systems have been proposed to allow optimized transport responses that can be explored in experimental realizations. In multiterminal systems, comparisons between schemes with different geometries are important to characterize the modifications introduced by mechanical deformations, especially if the deformations are localized at a central part of the system or extended in a large region. Then, in the present analysis, we study the strain effects on the transport properties of triangular and hexagonal graphene flakes, with zigzag and armchair edges, connected to three electronic terminals, formed by semi-infinite graphene nanoribbons. Using the Green's function formalism with circular renormalization schemes, and a single band tight-binding approximation, we find that resonant tunneling transport becomes relevant and is more affected by localized deformations in the hexagonal graphene flakes. Moreover, triangular systems with deformation extended to the leads, like longitudinal three-folded type, are shown as an interesting scenario for building nanoscale waveguides for electronic current.

Seasonal Storminess in the North Pacific, Bering Sea, and Alaskan Regions

NASA Astrophysics Data System (ADS)

Shippee, N. J.; Atkinson, D. E.; Walsh, J. E.; Partain, J.; Gottschalck, J.; Marra, J.

2012-12-01

Annually, extra-tropical cyclones present a high impact natural hazard to the North Pacific, Bering Sea, and Alaskan regions. In these regions, extensive subsistence and commercial fishing, new oil and gas field development, tourism, growing interest in and exploitation of new commercial shipping potential, and increasing military and Coast Guard activity, all represent potential parties impacted by storms in these waters. It is of interest to many parties to begin developing capacity to provide some indication of storm activity at a monthly- to seasonal-outlook (30 to 90 days) timeframe. Using storm track data from NOAA's Climate Prediction Center for the North Pacific and Alaskan region, an experimental seasonal storminess outlook product, using eigen-based methods similar to the operational seasonal temperature and precipitation products currently produced at NOAA CPC, has been created and tested in hindcast mode using predicted states of ENSO, the Pacific Decadal Oscillation (PDO), the Pacific-North American Pattern (PNA), and the Arctic Oscillation (AO). A sample of the seasonal storminess outlook product will be shown along with a discussion of the utility of individual teleconnection patterns in the generation of the product.

Novel approaches to optomechanical transduction

NASA Astrophysics Data System (ADS)

Cernotik, Ondrej; Hammerer, Klemens

In recent years, mechanical oscillators received attention as a promising tool for frequency conversion between microwaves and light. A general, bi-directional transducer with high efficiency is still far from reach of current technology; finding new strategies for optomechanical transduction allows us to relax the requirements and bring these systems closer to an experimental realization. An interesting example is generation of entanglement between two superconducting qubits using measurement and postselection. Here, the mechanical oscillators interacts directly with the superconducting transmon qubit in such a way that it feels a qubit-state dependent force. This force can then be read out using a cavity field; reading out two such systems sequentially realizes an effective total spin measurement. Starting from a suitable initial state and employing postselection, entanglement can be generated. Another interesting approach is to use an array of optomechanical transducers in which the output fields of one transducer are fed into the input of the next. The periodicity of the array results in a joint dispersion relation for the propagating microwave and optical fields. The resulting structure can be used to control the conversion bandwidth and forward and backward scattering.

JINR: the initiator of future discoveries

NASA Astrophysics Data System (ADS)

Matveev, V. A.

2016-03-01

On 26 March 2016, the Joint Institute for Nuclear Research (JINR) will mark its 60th anniversary as an internationally known research center that is a unique example of how fundamental theoretical and experimental studies can be integrated with the development and application of cutting-edge technologies and with university education. JINR member states number 18, of which Hungary, Germany, Egypt, Italy, Serbia, and the Republic of South Africa are each under a government-level cooperation agreement with the institute. Three factors combine to form a solid foundation on which JINR bases its work: commitment to traditions of internationally renowned research schools; unique performance hardware capable of solving problems of current interest in various fields of modern physics; and status as a UN intergovernmental body. Ranked high within the world's scientific community, the institute has conducted a wide range of research and trained high quality research personnel for its member states over the 60-years period since its foundation. In accordance with its Charter, JINR is open to participation by all interested states and ensures equal and mutually beneficial cooperation among them.

Tearing mode dynamics in the RFX-mod tokamak

NASA Astrophysics Data System (ADS)

Cordaro, Luigi; Zanca, Paolo; Zuin, Matteo; Auriemma, Fulvio; Martines, Emilio; Zaniol, Barbara; Pucella, Gianluca; Cavazzana, Roberto; de Masi, Gianluca; Fassina, Alessandro; Grenfell, Gustavo; Momo, Barbara; Spagnolo, Silvia; Spolaore, Monica; Vianello, Nicola

2017-10-01

The study of the physical mechanisms that influence the tearing mode (TM) rotation is of interest because, while in present day devices, a significant TM rotation can be induced by Neutral Beam Injection, future reactors, ITER included, are not expected to provide enough induced momentum. We present a study of tearing mode dynamics in the RFX-mod device, a Reserved Field Pinch in Padua (Italy) that can be run as low-current, circular tokamak. Magnetic, flow and kinetic measurements are integrated to characterize the (2,1) and (3,2) TMs fast rotation. We are especially interested to study the role played by the diamagnetic electron drift on the TM rotation, including the slowing down and the wall-locking phases. When the latter occurs, the radial magnetic field penetrates the shell and the TM amplitude increases at a rate given by the wall resistive time constant. This phenomenon can lead to a rapid discharge termination via a disruption. A comparison of experimental data with a two-fluid MHD cylindrical model has been used to interpret the observed TM fast rotation frequencies.

Work plan for improving the DARWIN2.3 depleted material balance calculation of nuclides of interest for the fuel cycle

NASA Astrophysics Data System (ADS)

Rizzo, Axel; Vaglio-Gaudard, Claire; Martin, Julie-Fiona; Noguère, Gilles; Eschbach, Romain

2017-09-01

DARWIN2.3 is the reference package used for fuel cycle applications in France. It solves the Boltzmann and Bateman equations in a coupling way, with the European JEFF-3.1.1 nuclear data library, to compute the fuel cycle values of interest. It includes both deterministic transport codes APOLLO2 (for light water reactors) and ERANOS2 (for fast reactors), and the DARWIN/PEPIN2 depletion code, each of them being developed by CEA/DEN with the support of its industrial partners. The DARWIN2.3 package has been experimentally validated for pressurized and boiling water reactors, as well as for sodium fast reactors; this experimental validation relies on the analysis of post-irradiation experiments (PIE). The DARWIN2.3 experimental validation work points out some isotopes for which the depleted concentration calculation can be improved. Some other nuclides have no available experimental validation, and their concentration calculation uncertainty is provided by the propagation of a priori nuclear data uncertainties. This paper describes the work plan of studies initiated this year to improve the accuracy of the DARWIN2.3 depleted material balance calculation concerning some nuclides of interest for the fuel cycle.

Oligodeoxynucleotides as Anti-Cancer Therapeutics and Diagnostics | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute Laboratory of Experimental Immunology is seeking statements of capability or interest from parties interested in licensing or collaborative research to further develop, evaluate, or commercialize anti-cancer oligodeoxynucleotides.  

Laughing Our Way to a Stronger Democracy: Political Comedy's Potential to Equalize Political Interest in Community College Students

ERIC Educational Resources Information Center

Lawrason, Lisa

2017-01-01

What effect does political comedy have on political interest? Through an experimental design, changes in political interest are measured through a pre and posttest, comparing groups randomly assigned to watch "The Daily Show," "NBC Nightly News," "Entertainment Tonight" and a no-exposure group. Models indicate…

The Roles of Ability, Personality, and Interests in Acquiring Current Events Knowledge: A Longitudinal Study

ERIC Educational Resources Information Center

Hambrick, David Z.; Pink, Jeffrey E.; Meinz, Elizabeth J.; Pettibone, Jonathan C.; Oswald, Frederick L.

2008-01-01

The purpose of this study was to investigate sources of inter-individual differences in current events knowledge. The study occurred in two sessions. In the initial session, 579 participants completed tests to ability, personality, and interest factors, as well as prior knowledge of current events. Approximately 10 weeks later, participants…

PREFACE: Proceedings of the International Workshop on Current Challenges in Liquid and Glass Science, (The Cosener's House, Abingdon 10 12 January 2007)

NASA Astrophysics Data System (ADS)

Hannon, Alex C.; Salmon, Philip S.; Soper, Alan K.

2007-10-01

The workshop was held to discuss current experimental and theoretical challenges in liquid and glass science and to honour the contribution made by Spencer Howells (ISIS, UK) to the field of neutron scattering from liquids and glasses. The meeting was attended by 70 experimentalists, theorists and computer simulators from Europe, Japan and North America and comprised 34 oral presentations together with two lively poster sessions. Three major themes were discussed, namely (i) the glass transition and properties of liquids and glasses under extreme conditions; (ii) the complementarity of neutron and x-ray scattering techniques with other experimental methods; and (iii) the modelling of liquid and glass structure. These themes served to highlight (a) recent advances in neutron and x-ray instrumentation used to investigate liquid and glassy materials under extreme conditions; (b) the relationship between the results obtained from different experimental and theoretical/computational methods; and (c) the modern methods used to interpret experimental results. The presentations ranged from polyamorphism in liquids and glasses to protein folding in aqueous solution and included the dynamics of fresh and freeze-dried strawberries and red onions. The properties of liquid phosphorus were also memorably demonstrated! The formal highlight was the 'Spencerfest' dinner where Neil Cowlam (Sheffield, UK) gave an excellent after dinner speech. The organisation of the workshop benefited tremendously from the secretarial skills of Carole Denning (ISIS, UK). The financial support of the Council for the Central Laboratory of the Research Councils (CCLRC), the Liquids and Complex Fluids Group of the Institute of Physics, The ISIS Disordered Materials Group, the CCLRC Centre for Materials Physics and Chemistry and the CCLRC Centre for Molecular Structure and Dynamics is gratefully acknowledged. Finally, it is a pleasure to thank all the workshop participants whose lively contributions led to the success of the meeting. The present special issue stems from the interest of many of those present to collect their work into a single volume.

Effectiveness of a neuropsychological treatment for confabulations after brain injury: A clinical trial with theoretical implications

PubMed Central

Triviño, Mónica; Ródenas, Estrella; Lupiáñez, Juan; Arnedo, Marisa

2017-01-01

Confabulators consistently generate false memories without intention to deceive and with great feelings of rightness. However, to our knowledge, there is currently no known effective treatment for them. In order to fill this gap, our aim was to design a neuropsychological treatment based on current theoretical models and test it experimentally in 20 confabulators sequentially allocated to two groups: an experimental and a control group. The experimental group received nine sessions of treatment for three weeks (three sessions per week). The sessions consisted of some brief material that participants had to learn and recall at both immediate and delayed time points. After this, patients were given feedback about their performance (errors and correct responses). Pre- and post-treatment measurements were recorded. Confabulators in the control group were included in a waiting list for three weeks, performed the pre- and post- measurements without treatment, and only then received the treatment, after which a post-treatment measurement was recorded. This applied to only half of the participants; the other half quit the study prematurely. Results showed a significant decrease in confabulations and a significant increase in correct responses in the experimental group; by contrast, patients in the control group did not improve during the waiting list period. Only control group patients who subsequently received the treatment after serving as controls improved. The effects of the treatment were generalized to patients’ everyday lives, as reported by relatives, and persisted over time. This treatment seems to be effective and easy to implement and consequently of clinical interest. Moreover, it also has theoretical implications regarding the processes related to the genesis and/or maintenance of confabulations. In particular, results point to a deficit in early stages of memory retrieval with the preservation of later strategic monitoring processes. Specifically, some of the processes involved may include selective attention or early conflict detection deficits. Future research should test these hypotheses. PMID:28257420

FCRD Transmutation Fuels Handbook 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janney, Dawn Elizabeth; Papesch, Cynthia Ann

2015-09-01

Transmutation of minor actinides such as Np, Am, and Cm in spent nuclear fuel is of international interest because of its potential for reducing the long-term health and safety hazards caused by the radioactivity of the spent fuel. One important approach to transmutation (currently being pursued by the DOE Fuel Cycle Research & Development Advanced Fuels Campaign) involves incorporating the minor actinides into U-Pu-Zr alloys, which can be used as fuel in fast reactors. It is, therefore, important to understand the properties of U-Pu-Zr alloys, both with and without minor actinide additions. In addition to requiring extensive safety precautions, alloysmore » containing U and Pu are difficult to study for numerous reasons, including their complex phase transformations, characteristically sluggish phase-transformation kinetics, tendency to produce experimental results that vary depending on the histories of individual samples, and sensitivity to contaminants such as oxygen in concentrations below a hundred parts per million. Many of the experimental measurements were made before 1980, and the level of documentation for experimental methods and results varies widely. It is, therefore, not surprising that little is known with certainty about U-Pu-Zr alloys, and that general acceptance of results sometimes indicates that there is only a single measurement for a particular property. This handbook summarizes currently available information about U, Pu, Zr, and alloys of two or three of these elements. It contains information about phase diagrams and related information (including phases and phase transformations); heat capacity, entropy, and enthalpy; thermal expansion; and thermal conductivity and diffusivity. In addition to presenting information about materials properties, it attempts to provide information about how well the property is known and how much variation exists between measurements. Although the handbook includes some references to publications about modeling, its primary focus is experimental data. Most of the data has been published elsewhere (although scattered throughout numerous references, some quite obscure); however, some data is presented here for the first time.« less

A network security monitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heberlein, L.T.; Dias, G.V.; Levitt, K.N.

1989-11-01

The study of security in computer networks is a rapidly growing area of interest because of the proliferation of networks and the paucity of security measures in most current networks. Since most networks consist of a collection of inter-connected local area networks (LANs), this paper concentrates on the security-related issues in a single broadcast LAN such as Ethernet. Specifically, we formalize various possible network attacks and outline methods of detecting them. Our basic strategy is to develop profiles of usage of network resources and then compare current usage patterns with the historical profile to determine possible security violations. Thus, ourmore » work is similar to the host-based intrusion-detection systems such as SRI's IDES. Different from such systems, however, is our use of a hierarchical model to refine the focus of the intrusion-detection mechanism. We also report on the development of our experimental LAN monitor currently under implementation. Several network attacks have been simulated and results on how the monitor has been able to detect these attacks are also analyzed. Initial results demonstrate that many network attacks are detectable with our monitor, although it can surely be defeated. Current work is focusing on the integration of network monitoring with host-based techniques. 20 refs., 2 figs.« less

Nonlinear Dynamics and Bifurcation Analysis of a Boost Converter for Battery Charging in Photovoltaic Applications

NASA Astrophysics Data System (ADS)

Al-Hindawi, Mohammed M.; Abusorrah, Abdullah; Al-Turki, Yusuf; Giaouris, Damian; Mandal, Kuntal; Banerjee, Soumitro

Photovoltaic (PV) systems with a battery back-up form an integral part of distributed generation systems and therefore have recently attracted a lot of interest. In this paper, we consider a system of charging a battery from a PV panel through a current mode controlled boost dc-dc converter. We analyze its complete nonlinear/nonsmooth dynamics, using a piecewise model of the converter and realistic nonlinear v-i characteristics of the PV panel. Through this study, it is revealed that system design without taking into account the nonsmooth dynamics of the converter combined with the nonlinear v-i characteristics of the PV panel can lead to unpredictable responses of the overall system with high current ripple and other undesirable phenomena. This analysis can lead to better designed converters that can operate under a wide variation of the solar irradiation and the battery's state of charge. We show that the v-i characteristics of the PV panel combined with the battery's output voltage variation can increase or decrease the converter's robustness, both under peak current mode control and average current mode control. We justify the observation in terms of the change in the discrete-time map caused by the nonlinear v-i characteristics of the PV panel. The theoretical results are validated experimentally.

Water-waves on linear shear currents. A comparison of experimental and numerical results.

NASA Astrophysics Data System (ADS)

Simon, Bruno; Seez, William; Touboul, Julien; Rey, Vincent; Abid, Malek; Kharif, Christian

2016-04-01

Propagation of water waves can be described for uniformly sheared current conditions. Indeed, some mathematical simplifications remain applicable in the study of waves whether there is no current or a linearly sheared current. However, the widespread use of mathematical wave theories including shear has rarely been backed by experimental studies of such flows. New experimental and numerical methods were both recently developed to study wave current interactions for constant vorticity. On one hand, the numerical code can simulate, in two dimensions, arbitrary non-linear waves. On the other hand, the experimental methods can be used to generate waves with various shear conditions. Taking advantage of the simplicity of the experimental protocol and versatility of the numerical code, comparisons between experimental and numerical data are discussed and compared with linear theory for validation of the methods. ACKNOWLEDGEMENTS The DGA (Direction Générale de l'Armement, France) is acknowledged for its financial support through the ANR grant N° ANR-13-ASTR-0007.

An improved DNA force field for ssDNA interactions with gold nanoparticles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Xiankai; Huai, Ping; Fan, Chunhai

The widespread applications of single-stranded DNA (ssDNA) conjugated gold nanoparticles (AuNPs) have spurred an increasing interest in the interactions between ssDNA and AuNPs. Despite extensive studies using the most sophisticated experimental techniques, the detailed molecular mechanisms still remain largely unknown. Large scale molecular dynamics (MD) simulations can thus be used to supplement experiments by providing complementary information about ssDNA-AuNP interactions. However, up to now, all modern force fields for DNA were developed based on the properties of double-stranded DNA (dsDNA) molecules, which have hydrophilic outer backbones “protecting” hydrophobic inner nucleobases from water. Without the double-helix structure of dsDNA and thusmore » the “protection” by the outer backbone, the nucleobases of ssDNA are directly exposed to solvent, and their behavior in water is very different from that of dsDNA, especially at the interface with nanoparticles. In this work, we have improved the force field of ssDNA for use with nanoparticles, such as AuNPs, based on recent experimental results and quantum mechanics calculations. With the new improved force field, we demonstrated that a poly(A) sequence adsorbed on a AuNP surface is much more stable than a poly(T) sequence, which is consistent with recent experimental observations. On the contrary, the current standard force fields, including AMBER03, CHARMM27, and OPLSAA, all gave erroneous results as compared to experiments. The current improved force field is expected to have wide applications in the study of ssDNA with nanomaterials including AuNPs, which might help promote the development of ssDNA-based biosensors and other bionano-devices.« less

An improved DNA force field for ssDNA interactions with gold nanoparticles

NASA Astrophysics Data System (ADS)

Jiang, Xiankai; Gao, Jun; Huynh, Tien; Huai, Ping; Fan, Chunhai; Zhou, Ruhong; Song, Bo

2014-06-01

The widespread applications of single-stranded DNA (ssDNA) conjugated gold nanoparticles (AuNPs) have spurred an increasing interest in the interactions between ssDNA and AuNPs. Despite extensive studies using the most sophisticated experimental techniques, the detailed molecular mechanisms still remain largely unknown. Large scale molecular dynamics (MD) simulations can thus be used to supplement experiments by providing complementary information about ssDNA-AuNP interactions. However, up to now, all modern force fields for DNA were developed based on the properties of double-stranded DNA (dsDNA) molecules, which have hydrophilic outer backbones "protecting" hydrophobic inner nucleobases from water. Without the double-helix structure of dsDNA and thus the "protection" by the outer backbone, the nucleobases of ssDNA are directly exposed to solvent, and their behavior in water is very different from that of dsDNA, especially at the interface with nanoparticles. In this work, we have improved the force field of ssDNA for use with nanoparticles, such as AuNPs, based on recent experimental results and quantum mechanics calculations. With the new improved force field, we demonstrated that a poly(A) sequence adsorbed on a AuNP surface is much more stable than a poly(T) sequence, which is consistent with recent experimental observations. On the contrary, the current standard force fields, including AMBER03, CHARMM27, and OPLSAA, all gave erroneous results as compared to experiments. The current improved force field is expected to have wide applications in the study of ssDNA with nanomaterials including AuNPs, which might help promote the development of ssDNA-based biosensors and other bionano-devices.

An improved DNA force field for ssDNA interactions with gold nanoparticles.

PubMed

Jiang, Xiankai; Gao, Jun; Huynh, Tien; Huai, Ping; Fan, Chunhai; Zhou, Ruhong; Song, Bo

2014-06-21

The widespread applications of single-stranded DNA (ssDNA) conjugated gold nanoparticles (AuNPs) have spurred an increasing interest in the interactions between ssDNA and AuNPs. Despite extensive studies using the most sophisticated experimental techniques, the detailed molecular mechanisms still remain largely unknown. Large scale molecular dynamics (MD) simulations can thus be used to supplement experiments by providing complementary information about ssDNA-AuNP interactions. However, up to now, all modern force fields for DNA were developed based on the properties of double-stranded DNA (dsDNA) molecules, which have hydrophilic outer backbones "protecting" hydrophobic inner nucleobases from water. Without the double-helix structure of dsDNA and thus the "protection" by the outer backbone, the nucleobases of ssDNA are directly exposed to solvent, and their behavior in water is very different from that of dsDNA, especially at the interface with nanoparticles. In this work, we have improved the force field of ssDNA for use with nanoparticles, such as AuNPs, based on recent experimental results and quantum mechanics calculations. With the new improved force field, we demonstrated that a poly(A) sequence adsorbed on a AuNP surface is much more stable than a poly(T) sequence, which is consistent with recent experimental observations. On the contrary, the current standard force fields, including AMBER03, CHARMM27, and OPLSAA, all gave erroneous results as compared to experiments. The current improved force field is expected to have wide applications in the study of ssDNA with nanomaterials including AuNPs, which might help promote the development of ssDNA-based biosensors and other bionano-devices.

Influence of Reduced Mass Flow Rate and Chamber Backpressure on Swirl Injector Fluid Mechanics

NASA Technical Reports Server (NTRS)

Kenny, R Jeremy; Hulka, James R.

2008-01-01

Industry interest in variable-thrust liquid rocket engines places a demand on engine injector technology to operate over a wide range of liquid mass flow rates and chamber backpressures. One injection technology of current interest for variable thrust applications is an injector design with swirled fluids. Current swirl injector design methodologies do not take into account how swirl injector design parameters respond to elevated chamber backpressures at less than design mass flow rates. The current work was created to improve state-of-the-art swirl injector design methods in this area. The specific objective was to study the effects of elevated chamber backpressure and off-design mass flow rates on swirl injector fluid mechanics. Using a backpressure chamber with optical access, water was flowed through a swirl injector at various combinations of chamber backpressure and mass flow rates. The film thickness profile down the swirl injector nozzle section was measured through a transparent nozzle section of the injector. High speed video showed measurable increases in the film thickness profile with application of chamber backpressure and mass flow rates less than design. At prescribed combinations of chamber backpressure and injected mass flow rate, a discrete change in the film thickness profile was observed. Measured injector discharge coefficient values showed different trends with increasing chamber backpressure at low mass flow rates as opposed to near-design mass flow rates. Downstream spray angles showed classic changes in morphology as the mass flow rate was decreased below the design value. Increasing chamber backpressure decreased the spray angle at any injection mass flow rate. Experimental measurements and discussion of these results are reported in this paper.

Global electric field determination in the Earth's outer magnetosphere using energetic charged particles

NASA Technical Reports Server (NTRS)

Eastman, Timothy E.; Sheldon, R.; Hamilton, D.

1995-01-01

Although many properties of the Earth's magnetosphere have been measured and quantified in the past 30 years since it was discovered, one fundamental measurement (for zeroth order MHD equilibrium) has been made infrequently and with poor spatial coverage - the global electric field. This oversight is due in part to the neglect of theorists. However, there is renewed interest in the convection electric field because it is now realized to be central to many magnetospheric processes, including the global MHD equilibrium, reconnection rates, Region 2 Birkeland currents, magnetosphere ionosphere coupling, ring current and radiation belt transport, substorm injections, and several acceleration mechanisms. Unfortunately the standard experimental methods have not been able to synthesize a global field (excepting the pioneering work of McIlwain's geostationary models) and we are left with an overly simplistic theoretical field, the Volland-Stern electric field model. Single point measurements of the plasmapause were used to infer the appropriate amplitudes of this model, parameterized by K(sub p). Although this result was never intended to be the definitive electric field model, it has gone nearly unchanged for 20 years. The analysis of current data sets requires a great deal more accuracy than can be provided by the Volland-Stern model. The variability of electric field shielding has not been properly addressed although effects of penetrating magnetospheric electric fields has been seen in mid-and low-latitude ionospheric data sets. The growing interest in substorm dynamics also requires a much better assessment of the electric fields responsible for particle injections. Thus we proposed and developed algorithms for extracting electric fields from particle data taken in the Earth's magnetosphere. As a test of the effectiveness of these new techniques, we analyzed data taken by the AMPTE/CCE spacecraft in equatorial orbit from 1984 to 1989.

The influence of the design matrix on treatment effect estimates in the quantitative analyses of single-subject experimental design research.

PubMed

Moeyaert, Mariola; Ugille, Maaike; Ferron, John M; Beretvas, S Natasha; Van den Noortgate, Wim

2014-09-01

The quantitative methods for analyzing single-subject experimental data have expanded during the last decade, including the use of regression models to statistically analyze the data, but still a lot of questions remain. One question is how to specify predictors in a regression model to account for the specifics of the design and estimate the effect size of interest. These quantitative effect sizes are used in retrospective analyses and allow synthesis of single-subject experimental study results which is informative for evidence-based decision making, research and theory building, and policy discussions. We discuss different design matrices that can be used for the most common single-subject experimental designs (SSEDs), namely, the multiple-baseline designs, reversal designs, and alternating treatment designs, and provide empirical illustrations. The purpose of this article is to guide single-subject experimental data analysts interested in analyzing and meta-analyzing SSED data. © The Author(s) 2014.

Experimental Research in School Psychology Internationally: An Assessment of Journal Publications and Implications for Internationalization

ERIC Educational Resources Information Center

Begeny, John C.; Levy, Rebecca A.; Hida, Rahma; Norwalk, Kate

2018-01-01

Past studies have examined the contents of journal articles in school psychology, and more recently there has been increased interest in examining the frequency and characteristics of experimental studies appearing in school psychology journals. However, no prior studies have examined the international representation of experimental and…

Development of the Biological Experimental Design Concept Inventory (BEDCI)

ERIC Educational Resources Information Center

Deane, Thomas; Nomme, Kathy; Jeffery, Erica; Pollock, Carol; Birol, Gulnur

2014-01-01

Interest in student conception of experimentation inspired the development of a fully validated 14-question inventory on experimental design in biology (BEDCI) by following established best practices in concept inventory (CI) design. This CI can be used to diagnose specific examples of non-expert-like thinking in students and to evaluate the…

Is Affect Aversive to Young Children with Autism: Behavioral and Cardiac Responses to Experimenter Distress.

ERIC Educational Resources Information Center

Corona, Rosalie; Dissanayake, Cheryl; Arbelle, Shoshana; Wellington, Peter; Sigman, Marian

1998-01-01

Compared attention, behavioral reaction, facial affect, and cardiac responses of 22 autistic and 22 mentally retarded preschoolers to emotional displays. Found that both groups looked more at the experimenter and displayed more interest and concern when the experimenter showed strong distress than when she showed neutral affect. Autistic…

[N.K. Kol'tsov and experimental embryology (dedicated to the 140th anniversary of his birth)].

PubMed

Pomelova, M A

2012-01-01

It is common knowledge that the majority ofN.K. Kol'tsov's studies investigated the structure of a cell through the methods of physical chemistry and cytogenetics. At the same time, Kol'tsov was also interested in the development of experimental biology, specifically experimental embryology.

Measurement realities of current collection in dynamic space plasma environments

NASA Technical Reports Server (NTRS)

Szuszczewicz, Edward P.

1990-01-01

Theories which describe currents collected by conducting and non-conducting bodies immersed in plasmas have many of their concepts based upon the fundamentals of sheath-potential distributions and charged-particle behavior in superimposed electric and magnetic fields. Those current-collecting bodies (or electrodes) may be Langmuir probes, electric field detectors, aperture plates on ion mass spectrometers and retarding potential analyzers, or spacecraft and their rigid and tethered appendages. Often the models are incomplete in representing the conditions under which the current-voltage characteristics of the electrode and its system are to be measured. In such cases, the experimenter must carefully take into account magnetic field effects and particle anisotropies, perturbations caused by the current collection process itself and contamination on electrode surfaces, the complexities of non-Maxwellian plasma distributions, and the temporal variability of the local plasma density, temperature, composition and fields. This set of variables is by no means all-inclusive, but it represents a collection of circumstances guaranteed to accompany experiments involving energetic particle beams, plasma discharges, chemical releases, wave injection and various events of controlled and uncontrolled spacecraft charging. Here, an attempt is made to synopsize these diagnostic challenges and frame them within a perspective that focuses on the physics under investigation and the requirements on the parameters to be measured. Examples include laboratory and spaceborne applications, with specific interest in dynamic and unstable plasma environments.

Optimising sulfuric acid hard coat anodising for an Al-Mg-Si wrought aluminium alloy

NASA Astrophysics Data System (ADS)

Bartolo, N.; Sinagra, E.; Mallia, B.

2014-06-01

This research evaluates the effects of sulfuric acid hard coat anodising parameters, such as acid concentration, electrolyte temperature, current density and time, on the hardness and thickness of the resultant anodised layers. A small scale anodising facility was designed and set up to enable experimental investigation of the anodising parameters. An experimental design using the Taguchi method to optimise the parameters within an established operating window was performed. Qualitative and quantitative methods of characterisation of the resultant anodised layers were carried out. The anodised layer's thickness, and morphology were determined using a light optical microscope (LOM) and field emission gun scanning electron microscope (FEG-SEM). Hardness measurements were carried out using a nano hardness tester. Correlations between the various anodising parameters and their effect on the hardness and thickness of the anodised layers were established. Careful evaluation of these effects enabled optimum parameters to be determined using the Taguchi method, which were verified experimentally. Anodised layers having hardness varying between 2.4-5.2 GPa and a thickness of between 20-80 μm were produced. The Taguchi method was shown to be applicable to anodising. This finding could facilitate on-going and future research and development of anodising, which is attracting remarkable academic and industrial interest.

An overview of malaria transmission from the perspective of Amazon Anopheles vectors

PubMed Central

Pimenta, Paulo FP; Orfano, Alessandra S; Bahia, Ana C; Duarte, Ana PM; Ríos-Velásquez, Claudia M; Melo, Fabrício F; Pessoa, Felipe AC; Oliveira, Giselle A; Campos, Keillen MM; Villegas, Luis Martínez; Rodrigues, Nilton Barnabé; Nacif-Pimenta, Rafael; Simões, Rejane C; Monteiro, Wuelton M; Amino, Rogerio; Traub-Cseko, Yara M; Lima, José BP; Barbosa, Maria GV; Lacerda, Marcus VG; Tadei, Wanderli P; Secundino, Nágila FC

2015-01-01

In the Americas, areas with a high risk of malaria transmission are mainly located in the Amazon Forest, which extends across nine countries. One keystone step to understanding the Plasmodium life cycle in Anopheles species from the Amazon Region is to obtain experimentally infected mosquito vectors. Several attempts to colonise Ano- pheles species have been conducted, but with only short-lived success or no success at all. In this review, we review the literature on malaria transmission from the perspective of its Amazon vectors. Currently, it is possible to develop experimental Plasmodium vivax infection of the colonised and field-captured vectors in laboratories located close to Amazonian endemic areas. We are also reviewing studies related to the immune response to P. vivax infection of Anopheles aquasalis, a coastal mosquito species. Finally, we discuss the importance of the modulation of Plasmodium infection by the vector microbiota and also consider the anopheline genomes. The establishment of experimental mosquito infections with Plasmodium falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide interesting models for studying malaria in the Amazonian scenario is important. Understanding the molecular mechanisms involved in the development of the parasites in New World vectors is crucial in order to better determine the interaction process and vectorial competence. PMID:25742262

G4RNA: an RNA G-quadruplex database

PubMed Central

Garant, Jean-Michel; Luce, Mikael J.; Scott, Michelle S.

2015-01-01

Abstract G-quadruplexes (G4) are tetrahelical structures formed from planar arrangement of guanines in nucleic acids. A simple, regular motif was originally proposed to describe G4-forming sequences. More recently, however, formation of G4 was discovered to depend, at least in part, on the contextual backdrop of neighboring sequences. Prediction of G4 folding is thus becoming more challenging as G4 outlier structures, not described by the originally proposed motif, are increasingly reported. Recent observations thus call for a comprehensive tool, capable of consolidating the expanding information on tested G4s, in order to conduct systematic comparative analyses of G4-promoting sequences. The G4RNA Database we propose was designed to help meet the need for easily-retrievable data on known RNA G4s. A user-friendly, flexible query system allows for data retrieval on experimentally tested sequences, from many separate genes, to assess G4-folding potential. Query output sorts data according to sequence position, G4 likelihood, experimental outcomes and associated bibliographical references. G4RNA also provides an ideal foundation to collect and store additional sequence and experimental data, considering the growing interest G4s currently generate. Database URL: scottgroup.med.usherbrooke.ca/G4RNA PMID:26200754

Piezoelectric Driving of Vibration Conveyors: An Experimental Assessment

PubMed Central

Rade, Domingos Alves; de Albuquerque, Emerson Bastos; Figueira, Leandro Chaves; Carvalho, João Carlos Mendes

2013-01-01

Vibratory feeders or vibratory conveyors have been widely used for the transport and orientation of individual parts and bulk materials in many branches of industrial activity. From the designer's standpoint, the current endeavor is to conceive efficient vibratory feeders, satisfying constraints of power consumption, vibration transmission and noise emission. Moreover, the interest in the reduction of maintenance cost is always present. In this context, this paper investigates experimentally the concept of vibratory conveying based on the use of piezoelectric materials for motion generation. A small-size prototype of a linear conveyor, in which lead-zirconate-titanate (PZT) patches are bonded to the resilient elements, is described. One of the main design goals is that the prototype is intended to be fed directly from the electric network, aiming at avoiding the use of electronic equipment for driving. To comply with this feature and, at the same time, enable to adjust the transport velocity, a mechanical device has been conceived in such a way that the first natural frequency of the conveyor can be changed. It is shown that the transport velocity is determined by the proximity between the excitation frequency and the first natural frequency of the conveyor. The experimental tests performed to characterize the dynamic behavior of the prototype are described and the range of transport velocities is determined. PMID:23867743

An overview of malaria transmission from the perspective of Amazon Anopheles vectors.

PubMed

Pimenta, Paulo F P; Orfano, Alessandra S; Bahia, Ana C; Duarte, Ana P M; Ríos-Velásquez, Claudia M; Melo, Fabrício F; Pessoa, Felipe A C; Oliveira, Giselle A; Campos, Keillen M M; Villegas, Luis Martínez; Rodrigues, Nilton Barnabé; Nacif-Pimenta, Rafael; Simões, Rejane C; Monteiro, Wuelton M; Amino, Rogerio; Traub-Cseko, Yara M; Lima, José B P; Barbosa, Maria G V; Lacerda, Marcus V G

2015-02-01

In the Americas, areas with a high risk of malaria transmission are mainly located in the Amazon Forest, which extends across nine countries. One keystone step to understanding the Plasmodium life cycle in Anopheles species from the Amazon Region is to obtain experimentally infected mosquito vectors. Several attempts to colonise Anopheles species have been conducted, but with only short-lived success or no success at all. In this review, we review the literature on malaria transmission from the perspective of its Amazon vectors. Currently, it is possible to develop experimental Plasmodium vivax infection of the colonised and field-captured vectors in laboratories located close to Amazonian endemic areas. We are also reviewing studies related to the immune response to P. vivax infection of Anopheles aquasalis, a coastal mosquito species. Finally, we discuss the importance of the modulation of Plasmodium infection by the vector microbiota and also consider the anopheline genomes. The establishment of experimental mosquito infections with Plasmodium falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide interesting models for studying malaria in the Amazonian scenario is important. Understanding the molecular mechanisms involved in the development of the parasites in New World vectors is crucial in order to better determine the interaction process and vectorial competence.

Fundamental Physics with Antihydrogen

NASA Astrophysics Data System (ADS)

Hangst, J. S.

Antihydrogen—the antimatter equivalent of the hydrogen atom—is of fundamental interest as a test bed for universal symmetries—such as CPT and the Weak Equivalence Principle for gravitation. Invariance under CPT requires that hydrogen and antihydrogen have the same spectrum. Antimatter is of course intriguing because of the observed baryon asymmetry in the universe—currently unexplained by the Standard Model. At the CERN Antiproton Decelerator (AD) [1], several groups have been working diligently since 1999 to produce, trap, and study the structure and behaviour of the antihydrogen atom. One of the main thrusts of the AD experimental program is to apply precision techniques from atomic physics to the study of antimatter. Such experiments complement the high-energy searches for physics beyond the Standard Model. Antihydrogen is the only atom of antimatter to be produced in the laboratory. This is not so unfortunate, as its matter equivalent, hydrogen, is one of the most well-understood and accurately measured systems in all of physics. It is thus very compelling to undertake experimental examinations of the structure of antihydrogen. As experimental spectroscopy of antihydrogen has yet to begin in earnest, I will give here a brief introduction to some of the ion and atom trap developments necessary for synthesizing and trapping antihydrogen, so that it can be studied.

An experimental approach to identify dynamical models of transcriptional regulation in living cells

NASA Astrophysics Data System (ADS)

Fiore, G.; Menolascina, F.; di Bernardo, M.; di Bernardo, D.

2013-06-01

We describe an innovative experimental approach, and a proof of principle investigation, for the application of System Identification techniques to derive quantitative dynamical models of transcriptional regulation in living cells. Specifically, we constructed an experimental platform for System Identification based on a microfluidic device, a time-lapse microscope, and a set of automated syringes all controlled by a computer. The platform allows delivering a time-varying concentration of any molecule of interest to the cells trapped in the microfluidics device (input) and real-time monitoring of a fluorescent reporter protein (output) at a high sampling rate. We tested this platform on the GAL1 promoter in the yeast Saccharomyces cerevisiae driving expression of a green fluorescent protein (Gfp) fused to the GAL1 gene. We demonstrated that the System Identification platform enables accurate measurements of the input (sugars concentrations in the medium) and output (Gfp fluorescence intensity) signals, thus making it possible to apply System Identification techniques to obtain a quantitative dynamical model of the promoter. We explored and compared linear and nonlinear model structures in order to select the most appropriate to derive a quantitative model of the promoter dynamics. Our platform can be used to quickly obtain quantitative models of eukaryotic promoters, currently a complex and time-consuming process.

State-variable theories for nonelastic deformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, C.Y.

The various concepts of mechanical equation of state for nonelastic deformation in crystalline solids, originally proposed for plastic deformation, have been recently extended to describe additional phenomena such as anelastic and microplastic deformation including the Bauschinger effect. It has been demonstrated that it is possible to predict, based on current state variables in a unified way, the mechanical response of a material under an arbitrary loading. Thus, if the evolution laws of the state variables are known, one can describe the behavior of a material for a thermal-mechanical path of interest, for example, during constant load (or stress) creep withoutmore » relying on specialized theories. Some of the existing theories of mechanical equation of state for nonelastic deformation are reviewed. The establishment of useful forms of mechanical equation of state has to depend on extensive experimentation in the same way as that involved in the development, for example, the ideal gas law. Recent experimental efforts are also reviewed. It has been possible to develop state-variable deformation models based on experimental findings and apply them to creep, cyclic deformation, and other time-dependent deformation. Attempts are being made to correlate the material parameters of the state-variable models with the microstructure of a material. 24 figures.« less

SIMULATING DEMAND FOR CIGARETTES AMONG PREGNANT WOMEN: A LOW-RISK METHOD FOR STUDYING VULNERABLE POPULATIONS

PubMed Central

Higgins, Stephen T.; Reed, Derek D.; Redner, Ryan; Skelly, Joan M.; Zvorsky, Ivori A.; Kurti, Allison N.

2016-01-01

A substantive obstacle to experimentally studying cigarette smoking and use of other tobacco products in pregnant women is the risk of adverse effects on mother and fetus from experimenter administration of the product of interest. The purpose of this study is to investigate bypassing that obstacle by using behavioral economic simulation tasks. In the present study we used the Cigarette Purchase Task (CPT) to simulate changes in demand for hypothetical cigarettes as a function of varying cigarette prices. Participants were 95 pregnant women who completed the CPT prior to participation in a smoking-cessation trial. Aggregate and individual participant demand varied as an orderly function of price and those changes were well fitted by an exponential equation. Demand also varied in correspondence to two well-validated predictors of individual differences in smoking cessation among pregnant women (cigarettes smoked per day, pre-pregnancy quit attempts). Moreover, CPT indices were more effective than these two conventional variables in predicting individual differences in whether women made a quit attempt during the current pregnancy. Overall, these results represent a promising step in demonstrating the validity and utility of the CPT for experimentally examining demand for cigarettes, and potentially other tobacco and nicotine delivery products, among pregnant women. PMID:28000917

Assessment of United States and Japanese Athletic Trainers' Satisfaction with Current Ascension Pathways and Interest in Future Transnational Certification

ERIC Educational Resources Information Center

Presuto, Dax A.

2013-01-01

Background: The purpose of this cross-system and cross-cultural study was to investigate the current athletic training systems in the US and Japan, to assess US and Japanese athletic trainers' satisfaction with current athletic training ascension pathways in their respective country and to determine their interest in future transnational…

Mode jumping of split-ring resonator metamaterials controlled by high-permittivity BST and incident electric fields

PubMed Central

Fu, Xiaojian; Zeng, Xinxi; Cui, Tie Jun; Lan, Chuwen; Guo, Yunsheng; Zhang, Hao Chi; Zhang, Qian

2016-01-01

We investigate the resonant modes of split-ring resonator (SRR) metamaterials that contain high-permittivity BST block numerically and experimentally. We observe interesting mode-jumping phenomena from the BST-included SRR absorber structure as the excitation wave is incident perpendicularly to the SRR plane. Specifically, when the electric field is parallel to the SRR gap, the BST block in the gap will induce a mode jumping from the LC resonance to plasmonic resonance (horizontal electric-dipole mode), because the displacement current excited by the Mie resonance in the dielectric block acts as a current channel in the gap. When the electric field is perpendicular to the gap side, the plasmonic resonance mode (vertical electric-dipole mode) in SRR changes to two joint modes contributed simultaneously by the back layer, SRR and BST block, as a result of connected back layer and SRR layer by the displacement current in the BST dielectric block. Based on the mode jumping effect as well as temperature and electric-field dependent dielectric constant, the BST-included SRR metamaterials may have great potentials for the applications in electromagnetic switches and widely tunable metamaterial devices. PMID:27502844

Design of a New Acceleration System for High-Current Pulsed Proton Beams from an ECR Source

NASA Astrophysics Data System (ADS)

Cooper, Andrew L.; Pogrebnyak, Ivan; Surbrook, Jason T.; Kelly, Keegan J.; Carlin, Bret P.; Champagne, Arthur E.; Clegg, Thomas B.

2014-03-01

A primary objective for accelerators at TUNL's Laboratory for Experimental Nuclear Astrophysics (LENA) is to maximize target beam intensity to ensure a high rate of nuclear events during each experiment. Average proton target currents of several mA are needed from LENA's electron cyclotron resonance (ECR) ion source because nuclear cross sections decrease substantially at energies of interest <200 keV. We seek to suppress undesired continuous environmental background by pulsing the beam and detecting events only during beam pulses. To improve beam intensity and transport, we installed a more powerful, stable microwave system for the ECR plasma, and will install a new acceleration system. This system will: reduce defocusing effects of the beam's internal space charge; provide better vacuum with a high gas conductance accelerating column; suppress bremsstrahlung X-rays produced when backstreaming electrons strike internal acceleration tube structures; and provide better heat dissipation by using deionized water to provide the current drain needed to establish the accelerating tube's voltage gradient. Details of beam optical modeling calculations, proposed accelerating tube design, and initial beam pulsing tests will be described. Work supported in part by USDOE Office of HE and Nuclear Physics.

Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives.

PubMed

Pengo, Paolo; Şologan, Maria; Pasquato, Lucia; Guida, Filomena; Pacor, Sabrina; Tossi, Alessandro; Stellacci, Francesco; Marson, Domenico; Boccardo, Silvia; Pricl, Sabrina; Posocco, Paola

2017-12-01

Molecular self-assembly is a topic attracting intense scientific interest. Various strategies have been developed for construction of molecular aggregates with rationally designed properties, geometries, and dimensions that promise to provide solutions to both theoretical and practical problems in areas such as drug delivery, medical diagnostics, and biosensors, to name but a few. In this respect, gold nanoparticles covered with self-assembled monolayers presenting nanoscale surface patterns-typically patched, striped or Janus-like domains-represent an emerging field. These systems are particularly intriguing for use in bio-nanotechnology applications, as presence of such monolayers with three-dimensional (3D) morphology provides nanoparticles with surface-dependent properties that, in turn, affect their biological behavior. Comprehensive understanding of the physicochemical interactions occurring at the interface between these versatile nanomaterials and biological systems is therefore crucial to fully exploit their potential. This review aims to explore the current state of development of such patterned, self-assembled monolayer-protected gold nanoparticles, through step-by-step analysis of their conceptual design, synthetic procedures, predicted and determined surface characteristics, interactions with and performance in biological environments, and experimental and computational methods currently employed for their investigation.

Comparison of experimental and theoretical reaction rail currents, rail voltages, and airgap fields for the linear induction motor research vehicle

NASA Technical Reports Server (NTRS)

Elliott, D. G.

1977-01-01

Measurements of reaction rail currents, reaction rail voltages, and airgap magnetic fields in tests of the Linear Induction Motor Research Vehicle (LIMRV) were compared with theoretical calculations from the mesh/matrix theory. It was found that the rail currents and magnetic fields predicted by the theory are within 20 percent of the measured currents and fields at most motor locations in most of the runs, but differ by as much as a factor of two in some cases. The most consistent difference is a higher experimental than theoretical magnetic field near the entrance of the motor and a lower experimental than theoretical magnetic field near the exit. The observed differences between the theoretical and experimental magnetic fields and currents do not account for the differences of as much as 26 percent between the theoretical and experimental thrusts.

History-Based Instruction Enriched with Various Sources of Situational Interest on the Topic of the Atom: the Effect on Students' Achievement and Interest

NASA Astrophysics Data System (ADS)

Pekdağ, Bülent; Azizoğlu, Nursen

2018-05-01

This study examines the effect of history-based instruction on the topic of the atom on students' academic achievement and their interest in the history of science, investigating as well the relationship between student interest and academic achievement. The sample of the study consisted of two groups of freshman students from an undergraduate elementary science teachers program. The same chemistry instructor taught the groups, which were randomly assigned as an experimental and a control group. The students in the control group received traditional teacher-centered instruction, while the experimental group students were taught the topic of the atom using history-based instruction enriched with various sources of situational interest such as novelty, autonomy, social involvement, and knowledge acquisition (NASK). Data gathering instruments were the Atom Achievement Test and the History of Science Interest Scale, administered to both of the groups before and after the instruction. The data were analyzed with the independent-samples t test, the paired-samples t test, and one-way ANCOVA statistical analysis. The results showed that the history-based instruction including NASK was more effective than traditional instruction in improving the students' learning of the subject of the atom as well as in stimulating and improving students' interest in the history of science. Further, students with high interest displayed significantly better achievement than students with low interest. The better learning of the topic of the atom was more pronounced in the case of students with a high interest in the history of science compared to students with moderate or low interest.

New trends in the nucleation research

NASA Astrophysics Data System (ADS)

Anisimov, M. P.; Hopke, P. K.

2017-09-01

During the last half of century the most of efforts have been directed towards small molecule system modeling using intermolecular potentials. Summarizing the nucleation theory, it can be concluded that the nowadays theory is far from complete. The vapor-gas nucleation theory can produce values that deviate from the experimental results by several orders of magnitude currently. Experiments on the vapor-gas nucleation rate measurements using different devices show significant inconsistencies in the measured rates as well. Theoretical results generally are quite reasonable for sufficiently low vapor nucleation rates where the capillary approximation is applicable. In the present research the advantages and current problems of the vapor-gas nucleation experiments are discussed briefly and a view of the future studies is presented. Using the brake points of the first derivative for the nucleation rate surface as markers of the critical embryos phase change is fresh idea to show the gas-pressure effect for the nucleating vapor-gas systems. To test the accuracy of experimental techniques, it is important to have a standard system that can be measured over a range of nucleation conditions. Several results illustrate that high-pressure techniques are needed to study multi-channel nucleation. In practical applications, parametric theories can be used for the systems of interest. However, experimental measurements are still the best source of information on nucleation rates. Experiments are labor intensive and costly, and thus, it is useful to extend the value of limited experimental measurements to a broader range of nucleation conditions. Only limited experimental data one needs for use in normalizing the slopes of the linearized nucleation rate surfaces. The nucleation rate surface is described in terms of steady-state nucleation rates. It is supposed that several new measuring systems, such as High Pressure Flow Diffusion Chamber for pressure limit up to 150 bar will be created soon in the frame of the Russian Ministry of Science & Education project under Contract № 14.Z50.31.0041 issued by February 13th of 2017. The Project will provide the nucleation studies for basic problems of theoretical and practical applications. Published under licence in Journal Title by IOP Publishing Ltd.

An intervention study to enhance girls' interest, self-concept, and achievement in physics classes

NASA Astrophysics Data System (ADS)

Häussler, Peter; Hoffmann, Lore

2002-11-01

Many interest studies have shown the decline of students' interest in physics during secondary education, particularly among girls. Research into physics-related interests of students suggests applying different measures to reduce or reverse that trend such as: (a) suggesting curricular changes that do justice to the specific interests and experiences of girls, (b) improving the ability of teachers to support girls in the development of a positive physics related self-concept, and (c) changing to an organizational setting that gives girls a better chance to improve their self-concept about physics. The purpose of this study was to examine whether these hypothetically effective measures lead to an improvement of the situation for girls when implemented in the physics classroom. The intervention took a whole school year of some 60 one-hour lessons and comprised 12 experimental and 7 control classes of seventh graders (age about 13). Their immediate and long-term achievements, as well as their change of interest in physics, their subjectively experienced competence, and their physics-related self-concept were assessed by written tests at various stages of the intervention. The intervention proved successful and significantly improved most of these indicators for girls (and boys) in the experimental group.

Geometry of thin liquid sheet flows

NASA Technical Reports Server (NTRS)

Chubb, Donald L.; Calfo, Frederick D.; Mcconley, Marc W.; Mcmaster, Matthew S.; Afjeh, Abdollah A.

1994-01-01

Incompresible, thin sheet flows have been of research interest for many years. Those studies were mainly concerned with the stability of the flow in a surrounding gas. Squire was the first to carry out a linear, invicid stability analysis of sheet flow in air and compare the results with experiment. Dombrowski and Fraser did an experimental study of the disintegration of sheet flows using several viscous liquids. They also detected the formulation of holes in their sheet flows. Hagerty and Shea carried out an inviscid stability analysis and calculated growth rates with experimental values. They compared their calculated growth rates with experimental values. Taylor studied extensively the stability of thin liquid sheets both theoretically and experimentally. He showed that thin sheets in a vacuum are stable. Brown experimentally investigated thin liquid sheet flows as a method of application of thin films. Clark and Dumbrowski carried out second-order stability analysis for invicid sheet flows. Lin introduced viscosity into the linear stability analysis of thin sheet flows in a vacuum. Mansour and Chigier conducted an experimental study of the breakup of a sheet flow surrounded by high-speed air. Lin et al. did a linear stability analysis that included viscosity and a surrounding gas. Rangel and Sirignano carried out both a linear and nonlinear invisid stability analysis that applies for any density ratio between the sheet liquid and the surrounding gas. Now there is renewed interest in sheet flows because of their possible application as low mass radiating surfaces. The objective of this study is to investigate the fluid dynamics of sheet flows that are of interest for a space radiator system. Analytical expressions that govern the sheet geometry are compared with experimental results. Since a space radiator will operate in a vacuum, the analysis does not include any drag force on the sheet flow.

A mixture theory approach to model co- and counter-current two-phase flow in porous media accounting for viscous coupling

NASA Astrophysics Data System (ADS)

Qiao, Y.; Andersen, P. Ø.; Evje, S.; Standnes, D. C.

2018-02-01

It is well known that relative permeabilities can depend on the flow configuration and they are commonly lower during counter-current flow as compared to co-current flow. Conventional models must deal with this by manually changing the relative permeability curves depending on the observed flow regime. In this paper we use a novel two-phase momentum-equation-approach based on general mixture theory to generate effective relative permeabilities where this dependence (and others) is automatically captured. In particular, this formulation includes two viscous coupling effects: (i) Viscous drag between the flowing phases and the stagnant porous rock; (ii) viscous drag caused by momentum transfer between the flowing phases. The resulting generalized model will predict that during co-current flow the faster moving fluid accelerates the slow fluid, but is itself decelerated, while for counter-current flow they are both decelerated. The implications of these mechanisms are demonstrated by investigating recovery of oil from a matrix block surrounded by water due to a combination of gravity drainage and spontaneous imbibition, a situation highly relevant for naturally fractured reservoirs. We implement relative permeability data obtained experimentally through co-current flooding experiments and then explore the model behavior for different flow cases ranging from counter-current dominated to co-current dominated. In particular, it is demonstrated how the proposed model seems to offer some possible interesting improvements over conventional modeling by providing generalized mobility functions that automatically are able to capture more correctly different flow regimes for one and the same parameter set.

New phenomena in non-equilibrium quantum physics

NASA Astrophysics Data System (ADS)

Kitagawa, Takuya

From its beginning in the early 20th century, quantum theory has become progressively more important especially due to its contributions to the development of technologies. Quantum mechanics is crucial for current technology such as semiconductors, and also holds promise for future technologies such as superconductors and quantum computing. Despite of the success of quantum theory, its applications have been mostly limited to equilibrium or static systems due to 1. lack of experimental controllability of non-equilibrium quantum systems 2. lack of theoretical frameworks to understand non-equilibrium dynamics. Consequently, physicists have not yet discovered too many interesting phenomena in non-equilibrium quantum systems from both theoretical and experimental point of view and thus, non-equilibrium quantum physics did not attract too much attentions. The situation has recently changed due to the rapid development of experimental techniques in condensed matter as well as cold atom systems, which now enables a better control of non-equilibrium quantum systems. Motivated by this experimental progress, we constructed theoretical frameworks to study three different non-equilibrium regimes of transient dynamics, steady states and periodically drives. These frameworks provide new perspectives for dynamical quantum process, and help to discover new phenomena in these systems. In this thesis, we describe these frameworks through explicit examples and demonstrate their versatility. Some of these theoretical proposals have been realized in experiments, confirming the applicability of the theories to realistic experimental situations. These studies have led to not only the improved fundamental understanding of non-equilibrium processes in quantum systems, but also suggested entirely different venues for developing quantum technologies.

Experimentation with human subjects: a critique of the views of Hans Jonas.

PubMed Central

Schafer, A

1983-01-01

The ethics of experimentation on human subjects has become the subject of much debate among medical scientists and philosophers. Ethical problems and conflicts of interest become especially serious when research subjects are recruited from the class of patients. Are patients who are ill and suffering in a position to give voluntary and informed consent? Are there inevitable conflicts of interest and moral obligation when a personal physician recruits his own patients for an experiment designed partly to advance scientific knowledge and only partly as therapy for those patients? The views of the eminent American ethicist Hans Jonas on these issues are briefly summarised and criticised, and some moral guidelines are then proposed to regulate experimentation on human subjects. PMID:6876101

First experimental evidence of hydrodynamic tunneling of ultra–relativistic protons in extended solid copper target at the CERN HiRadMat facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmidt, R.; Grenier, D.; Wollmann, D.

2014-08-15

A novel experiment has been performed at the CERN HiRadMat test facility to study the impact of the 440 GeV proton beam generated by the Super Proton Synchrotron on extended solid copper cylindrical targets. Substantial hydrodynamic tunneling of the protons in the target material has been observed that leads to significant lengthening of the projectile range, which confirms our previous theoretical predictions [N. A. Tahir et al., Phys. Rev. Spec. Top.-Accel. Beams 15, 051003 (2012)]. Simulation results show very good agreement with the experimental measurements. These results have very important implications on the machine protection design for powerful machines like themore » Large Hadron Collider (LHC), the future High Luminosity LHC, and the proposed huge 80 km circumference Future Circular Collider, which is currently being discussed at CERN. Another very interesting outcome of this work is that one may also study the field of High Energy Density Physics at this test facility.« less

Dynamics of plasma−dust structures formed in a trap created in the narrowing of a current channel in a magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dzlieva, E. S., E-mail: plasmadust@yandex.ru; Karasev, V. Yu., E-mail: v.karasev@spbu.ru; Pavlov, S. I.

The geometry and dynamics of plasma−dust structures in a longitudinal magnetic field is studied experimentally. The structures are formed in a glow-discharge trap created in the double electric layer produced as a result of discharge narrowing by means of a dielectric insert introduced in the discharge tube. Studies of structures formed in the new type of glow-discharge trap are of interest from the standpoint of future experiments with complex plasmas in superstrong magnetic fields in which the dust component is magnetized. Different types of dielectric inserts were used: conical and plane ones with symmetric and asymmetric apertures. Conditions for themore » existence of stable dust structures are determined for dust grains of different density and different dispersity. According to the experimental results, the angular velocity of dust rotation is ≥10 s{sup –1}, which is the fastest type of dust motion for all types of discharges in a magnetic field. The rotation is interpreted by analyzing the dynamics of individual dust grains.« less

The effects of capsaicin and capsaicinoid analogs on metabolic molecular targets in highly energetic tissues and cell types.

PubMed

Gannon, Nicholas P; Lambalot, Emily L; Vaughan, Roger A

2016-05-01

There is increasing interest in dietary chemicals that may provide benefits for pathologies such as diabetes and obesity. Capsaicinoids found in chili peppers and pepper extracts, are responsible for the "hot" or "spicy" sensation associated with these foods. Capsaicinoid consumption is also associated with enhanced metabolism, making them potentially therapeutic for metabolic disease by promoting weight loss. This review summarizes much of the current experimental evidence (ranging from basic to applied investigations) of the biochemical and molecular metabolic effects of capsaicinoids in metabolically significant cell types. Along with influencing metabolic rate, findings demonstrate capsaicinoids appear to alter molecular metabolic signaling, regulate hunger and satiety, blood metabolites, and catecholamine release. Notably, the majority of the experiments summarized herein utilized isolated supplemental or research grade capsaicinoids rather than natural food sources for experimental interventions. Additional work should be conducted using primary food sources of capsaicin to explore pharmacological, physiological, and metabolic benefits of both chronic and acute capsaicin consumption. © 2016 BioFactors, 42(3):229-246, 2016. © 2016 International Union of Biochemistry and Molecular Biology.

Atomically resolved tissue integration.

PubMed

Karlsson, Johan; Sundell, Gustav; Thuvander, Mattias; Andersson, Martin

2014-08-13

In the field of biomedical technology, a critical aspect is the ability to control and understand the integration of an implantable device in living tissue. Despite the technical advances in the development of biomaterials, the elaborate interplay encompassing materials science and biology on the atomic level is not very well understood. Within implantology, anchoring a biomaterial device into bone tissue is termed osseointegration. In the most accepted theory, osseointegration is defined as an interfacial bonding between implant and bone; however, there is lack of experimental evidence to confirm this. Here we show that atom probe tomography can be used to study the implant-tissue interaction, allowing for three-dimensional atomic mapping of the interface region. Interestingly, our analyses demonstrated that direct contact between Ca atoms and the implanted titanium oxide surface is formed without the presence of a protein interlayer, which means that a pure inorganic interface is created, hence giving experimental support to the current theory of osseointegration. We foresee that this result will be of importance in the development of future biomaterials as well as in the design of in vitro evaluation techniques.

Containment system for experiments on radioactive and other hazardous materials in a Paris-Edinburgh press

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobsen, M. K., E-mail: mjacobsen@lanl.gov; Velisavljevic, N.

2015-11-15

Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions. However, its application to some materials of interest, such as high hazard materials that require special handling due to safety issues, reactivity, or other challenges, has not been feasible without the introduction of special containment systems to eliminate the hazards. However, introduction of a containment system is challenging due to the requirement to provide full safety containment for operation in the variety of environments available, while not hindering any of the experimental probes that are available for inert samplemore » measurement. In this work, we report on the development and implementation of a full safety enclosure for a Paris-Edinburgh type press. During the initial development and subsequent application stage of work, experiments were performed on both cerium dioxide (CeO{sub 2}) and uranium (U). This device allows for full implementation of all currently available experimental probes involving the Paris-Edinburgh press at the High Pressure Collaborative Access Team sector of the Advanced Photon Source.« less

Abalone viral ganglioneuritis: establishment and use of an experimental immersion challenge system for the study of abalone herpes virus infections in Australian abalone.

PubMed

Corbeil, Serge; McColl, Kenneth A; Williams, Lynette M; Mohammad, Ilhan; Hyatt, Alexander D; Crameri, Sandra G; Fegan, Mark; Crane, Mark St J

2012-05-01

In late 2005, acute mortalities occurred in abalone on farms located in Victoria, Australia. Disease was associated with infection by an abalone herpes virus (AbHV). Subsequently, starting in 2006, the disease (abalone viral ganglioneuritis; AVG) was discovered in wild abalone in Victorian open waters. Currently, it continues to spread, albeit at a slow rate, along the Victorian coast-line. Here, we report on experimental transmission trials that were carried out by immersion using water into which diseased abalone had shed infectious viral particles. At various time points following exposure, naïve abalone were assessed by an AbHV-specific real-time PCR and histological analyses including in situ hybridization (ISH). Results demonstrated that while exposed abalone began displaying clinical signs of the disease from 60 hours post exposure (hpe), they tested positive for the presence of viral DNA at 36 hpe. Of further interest, the AbHV DNA probe used in the ISH assay detected the virus as early as 48 hpe. Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.

Experimental Evaluation of Grid Support Enabled PV Inverter Response to Abnormal Grid Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Austin A; Martin, Gregory D; Hurtt, James

As revised interconnection standards for grid-tied photovoltaic (PV) inverters address new advanced grid support functions (GSFs), there is increasing interest in inverter performance in the case of abnormal grid conditions. The growth of GSF-enabled inverters has outpaced the industry standards that define their operation, although recently published updates to UL1741 Supplement SA define test conditions for GSFs such as volt-var control, frequency-watt control, and voltage/frequency ride-through, among others. This paper describes the results of a comparative experimental evaluation on four commercially available, three-phase PV inverters in the 24.0-39.8 kVA power range on their GSF capability and its effect on abnormalmore » grid condition response. The evaluation examined the impact particular GSF implementations have on run-on times during islanding conditions, peak voltages in load rejection overvoltage scenarios, and peak currents during single-phase and three-phase fault events for individual inverters. Testing results indicated a wide variance in the performance of GSF enabled inverters to various test cases.« less

Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats

PubMed Central

Al-Attar, Atef M.; Shawush, Nessreen A.

2014-01-01

The current study was undertaken to evaluate the protective activity of olive and rosemary leaves extracts on experimental liver cirrhosis induced by thioacetamide (TAA) in Wistar male rats. Highly significant decline in the values of body weight gain and highly statistically increase of liver/body weight ratio were noted in rats treated with TAA. Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase and total bilirubin were statistically increased. Additionally, light microscopic examination of liver sections from rats treated with TAA showed a marked increase in the extracellular matrix collagen content and bridging fibrosis was prominent. There were bundles of collagen surrounding the lobules that resulted in large fibrous septa and distorted tissue architecture. Interestingly, the findings of this experimental study indicated that the extracts of olive and rosemary leaves and their combination possess hepatoprotective properties against TAA-induced hepatic cirrhosis by inhibiting the physiological and histopathological alterations. Moreover, these results suggest that the hepatoprotective effects of these extracts may be attributed to their antioxidant activities. PMID:25737646

A Parametric Oscillator Experiment for Undergraduates

NASA Astrophysics Data System (ADS)

Huff, Alison; Thompson, Johnathon; Pate, Jacob; Kim, Hannah; Chiao, Raymond; Sharping, Jay

We describe an upper-division undergraduate-level analytic mechanics experiment or classroom demonstration of a weakly-damped pendulum driven into parametric resonance. Students can derive the equations of motion from first principles and extract key oscillator features, such as quality factor and parametric gain, from experimental data. The apparatus is compact, portable and easily constructed from inexpensive components. Motion control and data acquisition are accomplished using an Arduino micro-controller incorporating a servo motor, laser sensor, and data logger. We record the passage time of the pendulum through its equilibrium position and obtain the maximum speed per oscillation as a function of time. As examples of the interesting physics which the experiment reveals, we present contour plots depicting the energy of the system as functions of driven frequency and modulation depth. We observe the transition to steady state oscillation and compare the experimental oscillation threshold with theoretical expectations. A thorough understanding of this hands-on laboratory exercise provides a foundation for current research in quantum information and opto-mechanics, where damped harmonic motion, quality factor, and parametric amplification are central.

Pumps for microfluidic cell culture.

PubMed

Byun, Chang Kyu; Abi-Samra, Kameel; Cho, Yoon-Kyoung; Takayama, Shuichi

2014-02-01

In comparison to traditional in vitro cell culture in Petri dishes or well plates, cell culture in microfluidic-based devices enables better control over chemical and physical environments, higher levels of experimental automation, and a reduction in experimental materials. Over the past decade, the advantages associated with cell culturing in microfluidic-based platforms have garnered significant interest and have led to a plethora of studies for high throughput cell assays, organs-on-a-chip applications, temporal signaling studies, and cell sorting. A clear concern for performing cell culture in microfluidic-based devices is deciding on a technique to deliver and pump media to cells that are encased in a microfluidic device. In this review, we summarize recent advances in pumping techniques for microfluidic cell culture and discuss their advantages and possible drawbacks. The ultimate goal of our review is to distill the large body of information available related to pumps for microfluidic cell culture in an effort to assist current and potential users of microfluidic-based devices for advanced in vitro cellular studies. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Speed scanning system based on solid-state microchip laser for architectural planning

NASA Astrophysics Data System (ADS)

Redka, Dmitriy; Grishkanich, Alexsandr S.; Kolmakov, Egor; Tsvetkov, Konstantin

2017-10-01

According to the current great interest concerning Large-Scale Metrology applications in many different fields of manufacturing industry, technologies and techniques for dimensional measurement have recently shown a substantial improvement. Ease-of-use, logistic and economic issues, as well as metrological performance, are assuming a more and more important role among system requirements. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of microlasers as radiators on the linear-angular characteristics of existing measurement systems. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of microlasers as radiators on the linear-angular characteristics of existing measurement systems. The system consists of a distributed network-based layout, whose modularity allows to fit differently sized and shaped working volumes by adequately increasing the number of sensing units. Differently from existing spatially distributed metrological instruments, the remote sensor devices are intended to provide embedded data elaboration capabilities, in order to share the overall computational load.

Coordinate measuring system based on microchip lasers for reverse prototyping

NASA Astrophysics Data System (ADS)

Iakovlev, Alexey; Grishkanich, Alexsandr S.; Redka, Dmitriy; Tsvetkov, Konstantin

2017-02-01

According to the current great interest concerning Large-Scale Metrology applications in many different fields of manufacturing industry, technologies and techniques for dimensional measurement have recently shown a substantial improvement. Ease-of-use, logistic and economic issues, as well as metrological performance, are assuming a more and more important role among system requirements. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of chip and microlasers as radiators on the linear-angular characteristics of existing measurement systems. The project is planned to conduct experimental studies aimed at identifying the impact of the application of the basic laws of microlasers as radiators on the linear-angular characteristics of existing measurement systems. The system consists of a distributed network-based layout, whose modularity allows to fit differently sized and shaped working volumes by adequately increasing the number of sensing units. Differently from existing spatially distributed metrological instruments, the remote sensor devices are intended to provide embedded data elaboration capabilities, in order to share the overall computational load.

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model.

PubMed

Mesquita, Ana; Cardenal-Muñoz, Elena; Dominguez, Eunice; Muñoz-Braceras, Sandra; Nuñez-Corcuera, Beatriz; Phillips, Ben A; Tábara, Luis C; Xiong, Qiuhong; Coria, Roberto; Eichinger, Ludwig; Golstein, Pierre; King, Jason S; Soldati, Thierry; Vincent, Olivier; Escalante, Ricardo

2017-01-02

Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum. Since the publication of the first review describing the potential of D. discoideum in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in D. discoideum has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in D. discoideum. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.

PredPsych: A toolbox for predictive machine learning-based approach in experimental psychology research.

PubMed

Koul, Atesh; Becchio, Cristina; Cavallo, Andrea

2017-12-12

Recent years have seen an increased interest in machine learning-based predictive methods for analyzing quantitative behavioral data in experimental psychology. While these methods can achieve relatively greater sensitivity compared to conventional univariate techniques, they still lack an established and accessible implementation. The aim of current work was to build an open-source R toolbox - "PredPsych" - that could make these methods readily available to all psychologists. PredPsych is a user-friendly, R toolbox based on machine-learning predictive algorithms. In this paper, we present the framework of PredPsych via the analysis of a recently published multiple-subject motion capture dataset. In addition, we discuss examples of possible research questions that can be addressed with the machine-learning algorithms implemented in PredPsych and cannot be easily addressed with univariate statistical analysis. We anticipate that PredPsych will be of use to researchers with limited programming experience not only in the field of psychology, but also in that of clinical neuroscience, enabling computational assessment of putative bio-behavioral markers for both prognosis and diagnosis.

Quantitative Aspects of Single Molecule Microscopy

PubMed Central

Ober, Raimund J.; Tahmasbi, Amir; Ram, Sripad; Lin, Zhiping; Ward, E. Sally

2015-01-01

Single molecule microscopy is a relatively new optical microscopy technique that allows the detection of individual molecules such as proteins in a cellular context. This technique has generated significant interest among biologists, biophysicists and biochemists, as it holds the promise to provide novel insights into subcellular processes and structures that otherwise cannot be gained through traditional experimental approaches. Single molecule experiments place stringent demands on experimental and algorithmic tools due to the low signal levels and the presence of significant extraneous noise sources. Consequently, this has necessitated the use of advanced statistical signal and image processing techniques for the design and analysis of single molecule experiments. In this tutorial paper, we provide an overview of single molecule microscopy from early works to current applications and challenges. Specific emphasis will be on the quantitative aspects of this imaging modality, in particular single molecule localization and resolvability, which will be discussed from an information theoretic perspective. We review the stochastic framework for image formation, different types of estimation techniques and expressions for the Fisher information matrix. We also discuss several open problems in the field that demand highly non-trivial signal processing algorithms. PMID:26167102

Free-Space Quantum Signatures Using Heterodyne Measurements.

PubMed

Croal, Callum; Peuntinger, Christian; Heim, Bettina; Khan, Imran; Marquardt, Christoph; Leuchs, Gerd; Wallden, Petros; Andersson, Erika; Korolkova, Natalia

2016-09-02

Digital signatures guarantee the authorship of electronic communications. Currently used "classical" signature schemes rely on unproven computational assumptions for security, while quantum signatures rely only on the laws of quantum mechanics to sign a classical message. Previous quantum signature schemes have used unambiguous quantum measurements. Such measurements, however, sometimes give no result, reducing the efficiency of the protocol. Here, we instead use heterodyne detection, which always gives a result, although there is always some uncertainty. We experimentally demonstrate feasibility in a real environment by distributing signature states through a noisy 1.6 km free-space channel. Our results show that continuous-variable heterodyne detection improves the signature rate for this type of scheme and therefore represents an interesting direction in the search for practical quantum signature schemes. For transmission values ranging from 100% to 10%, but otherwise assuming an ideal implementation with no other imperfections, the signature length is shorter by a factor of 2 to 10. As compared with previous relevant experimental realizations, the signature length in this implementation is several orders of magnitude shorter.

Developing Tools and Techniques to Increase Communication Effectiveness

NASA Technical Reports Server (NTRS)

Hayes, Linda A.; Peterson, Doug

1997-01-01

The Public Affairs Office (PAO) of the Johnson Space Center (JSC) is responsible for communicating current JSC Space Program activities as well as goals and objectives to the American Public. As part of the 1996 Strategic Communications Plan, a review of PAO' s current communication procedures was conducted. The 1996 Summer Faculty Fellow performed research activities to support this effort by reviewing current research concerning NASA/JSC's customers' perceptions and interests, developing communications tools which enable PAO to more effectively inform JSC customers about the Space Program, and proposing a process for developing and using consistent messages throughout PAO. Note that this research does not attempt to change or influence customer perceptions or interests but, instead, incorporates current customer interests into PAO's communication process.

Biodegradable materials for surgical management of infective endocarditis: new solution or a dead end street?

PubMed

Myers, Patrick O; Cikirikcioglu, Mustafa; Kalangos, Afksendiyos

2014-08-03

One third of patients with infective endocarditis will require operative intervention. Given the superiority of valve repair over valve replacement in many indications other than endocarditis, there has been increasing interest and an increasing number of reports of excellent results of valve repair in acute infective endocarditis. The theoretically ideal material for valve repair in this setting is non-permanent, "vanishing" material, not at risk of seeding or colonization. The goal of this contribution is to review currently available data on biodegradable materials for valve repair in infective endocarditis. Rigorous electronic and manual literature searches were conducted to identify reports of biodegradable materials for valve repair in infective endocarditis. Articles were identified in electronic database searches of Medline, Embase and the Cochrane Library, using a predetermined search strategy. 49 manuscripts were included in the review. Prosthetic materials needed for valve repair can be summarized into annuloplasty rings to remodel the mitral or tricuspid annulus, and patch materials to replace resected valvar tissue. The commercially available biodegradable annuloplasty ring has shown interesting clinical results in a single-center experience; however further data is required for validation and longer follow-up. Unmodified extra-cellular matrix patches, such as small intestinal submucosa, have had promising initial experimental and clinical results in non-infected valve repair, although in valve repair for endocarditis has been reported in only one patient, and concerns have been raised regarding their mechanical stability in an infected field. These evolving biodegradable devices offer the potential for valve repair with degradable materials replaced with autologous tissue, which could further improve the results of valve repair for infective endocarditis. This is an evolving field with promising experimental or initial clinical results, however long-term outcomes are lacking and further data is necessary to validate this theoretically interesting approach to infective endocarditis.

Biodegradable materials for surgical management of infective endocarditis: new solution or a dead end street?

PubMed Central

2014-01-01

Background One third of patients with infective endocarditis will require operative intervention. Given the superiority of valve repair over valve replacement in many indications other than endocarditis, there has been increasing interest and an increasing number of reports of excellent results of valve repair in acute infective endocarditis. The theoretically ideal material for valve repair in this setting is non-permanent, “vanishing” material, not at risk of seeding or colonization. The goal of this contribution is to review currently available data on biodegradable materials for valve repair in infective endocarditis. Discussion Rigorous electronic and manual literature searches were conducted to identify reports of biodegradable materials for valve repair in infective endocarditis. Articles were identified in electronic database searches of Medline, Embase and the Cochrane Library, using a predetermined search strategy. 49 manuscripts were included in the review. Prosthetic materials needed for valve repair can be summarized into annuloplasty rings to remodel the mitral or tricuspid annulus, and patch materials to replace resected valvar tissue. The commercially available biodegradable annuloplasty ring has shown interesting clinical results in a single-center experience; however further data is required for validation and longer follow-up. Unmodified extra-cellular matrix patches, such as small intestinal submucosa, have had promising initial experimental and clinical results in non-infected valve repair, although in valve repair for endocarditis has been reported in only one patient, and concerns have been raised regarding their mechanical stability in an infected field. Summary These evolving biodegradable devices offer the potential for valve repair with degradable materials replaced with autologous tissue, which could further improve the results of valve repair for infective endocarditis. This is an evolving field with promising experimental or initial clinical results, however long-term outcomes are lacking and further data is necessary to validate this theoretically interesting approach to infective endocarditis. PMID:25087015

Anesthesia and Monitoring in Small Laboratory Mammals Used in Anesthesiology, Respiratory and Critical Care Research: A Systematic Review on the Current Reporting in Top-10 Impact Factor Ranked Journals

PubMed Central

Koch, Thea; Gama de Abreu, Marcelo; Spieth, Peter Markus

2015-01-01

Rationale This study aimed to investigate the quality of reporting of anesthesia and euthanasia in experimental studies in small laboratory mammals published in the top ten impact factor journals. Methods A descriptive systematic review was conducted and data was abstracted from the ten highest ranked journals with respect to impact factor in the categories ‘Anesthesiology’, ‘Critical Care Medicine’ and ‘Respiratory System’ as defined by the 2012 Journal Citation Reports. Inclusion criteria according to PICOS criteria were as follows: 1) population: small laboratory mammals; 2) intervention: any form of anesthesia and/or euthanasia; 3) comparison: not specified; 4) primary outcome: type of anesthesia, anesthetic agents and type of euthanasia; secondary outcome: animal characteristics, monitoring, mechanical ventilation, fluid management, postoperative pain therapy, animal care approval, sample size calculation and performed interventions; 5) study: experimental studies. Anesthesia, euthanasia, and monitoring were analyzed per performed intervention in each article. Results The search yielded 845 articles with 1,041 interventions of interest. Throughout the manuscripts we found poor quality and frequency of reporting with respect to completeness of data on animal characteristics as well as euthanasia, while anesthesia (732/1041, 70.3%) and interventions without survival (970/1041, 93.2%) per se were frequently reported. Premedication and neuromuscular blocking agents were reported in 169/732 (23.1%) and 38/732 (5.2%) interventions, respectively. Frequency of reporting of analgesia during (117/610, 19.1%) and after painful procedures (38/364, 10.4%) was low. Euthanasia practice was reported as anesthesia (348/501, 69%), transcardial perfusion (37/501, 8%), carbon dioxide (26/501, 6%), decapitation (22/501, 5%), exsanguination (23/501, 5%), other (25/501, 5%) and not specified (20/501, 4%, respectively. Conclusions The present systematic review revealed insufficient reporting of anesthesia and euthanasia methods throughout experimental studies in small laboratory mammals. Specific guidelines for anesthesia and euthanasia regimens should be considered to achieve comparability, quality of animal experiments and animal welfare. These measures are of special interest when translating experimental findings to future clinical applications. PMID:26305700

12 CFR 602.10 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... information for a use or purpose that furthers the commercial, trade, or profit interests of that individual... higher education, an institution of professional education, or an institution of vocational education... means information about current events or of current interest to the public. Reproduce (or reproduction...

Experimental Analysis of Critical Current and Alternating Current Losses of High-Temperature Superconductor Tape with Resin and Gallium-Indium-Tin

PubMed Central

Sun, Yajie; Zhang, Huiming; Meng, Yuanzhu

2018-01-01

This paper experimentally analyzes the critical current degradation and AC (alternating current) losses of second-generation (2G) high-temperature superconductor (HTS) tape during the impregnation process. Two impregnation materials were utilized: Gallium-Indium-Tin (GaInSn), and an epoxy resin, Araldite. The critical current of the impregnation materials was measured after different thermal cycles and compared with the tape with no impregnation process. The experimental results show that the critical current of Yttrium Barium Copper Oxide (YBCO) short samples varies between differently impregnated materials. The resin, Araldite, degraded the critical current; however, the GaInSn showed no degradation. Two degradation patterns with Araldite were identified due to the impregnation process, and the corresponding causes were analyzed. We further measured the AC losses of tapes impregnated with liquid metal at different frequencies, up to 600 Hz. Based on the experimental results, GaInSn liquid metal should be the most suitable impregnation material in terms of critical current degradation. PMID:29642490

Experimental Analysis of Critical Current and Alternating Current Losses of High-Temperature Superconductor Tape with Resin and Gallium-Indium-Tin.

PubMed

Yu, Dongmin; Sun, Yajie; Zhang, Huiming; Meng, Yuanzhu; Liu, Huanan

2018-04-08

This paper experimentally analyzes the critical current degradation and AC (alternating current) losses of second-generation (2G) high-temperature superconductor (HTS) tape during the impregnation process. Two impregnation materials were utilized: Gallium-Indium-Tin (GaInSn), and an epoxy resin, Araldite. The critical current of the impregnation materials was measured after different thermal cycles and compared with the tape with no impregnation process. The experimental results show that the critical current of Yttrium Barium Copper Oxide (YBCO) short samples varies between differently impregnated materials. The resin, Araldite, degraded the critical current; however, the GaInSn showed no degradation. Two degradation patterns with Araldite were identified due to the impregnation process, and the corresponding causes were analyzed. We further measured the AC losses of tapes impregnated with liquid metal at different frequencies, up to 600 Hz. Based on the experimental results, GaInSn liquid metal should be the most suitable impregnation material in terms of critical current degradation.

Spectroscopic Diagnostics of Electric Fields in the Plasma of Current Sheets

NASA Astrophysics Data System (ADS)

Gavrilenko, Valeri; Kyrie, Natalya P.; Frank, Anna G.; Oks, Eugene

2004-11-01

Spectroscopic measurements of electric fields (EFs) in current sheet plasmas were performed in the CS-3D device. The device is intended to study the evolution of current sheets and the magnetic reconnection phenomena. We used the broadening of spectral lines (SLs) of HeII ions for diagnostics of EFs in the current sheet middle plane, and the broadening of SLs of HeI atoms for detection of EFs in the current sheet peripheral regions. For detection of EFs in current sheet plasma, we used SLs of HeII ions at 468.6; 320.3 and 656.0 nm, as well as SLs of HeI atoms at 667.8; 587.6; 492.2 and 447.1 nm. The latter two lines are of a special interest since their profiles include the dipole-forbidden components along with the allowed components. The experimental data have been analyzed by using the numerical calculations based on the Model Microfield Method. The maximum plasma density in the middle of the sheet was in the range (2-8) × 10^16 cm-3, the density in the peripheral regions was (1-2)×10^15 cm-3, and the strength of the quasi-one-dimensional anomalous electric fields in the peripheral regions reached the value of 100 kV/cm. Supported by CRDF, grant RU-P1-2594-MO-04; by the RFBR, grant 03-02-17282; and by the ISTC, project 2098.

The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration

PubMed Central

Makris, Eleftherios A.; Hadidi, Pasha; Athanasiou, Kyriacos A.

2011-01-01

Extensive scientific investigations in recent decades have established the anatomical, biomechanical, and functional importance that the meniscus holds within the knee joint. As a vital part of the joint, it acts to prevent the deterioration and degeneration of articular cartilage, and the onset and development of osteoarthritis. For this reason, research into meniscus repair has been the recipient of particular interest from the orthopedic and bioengineering communities. Current repair techniques are only effective in treating lesions located in the peripheral vascularized region of the meniscus. Healing lesions found in the inner avascular region, which functions under a highly demanding mechanical environment, is considered to be a significant challenge. An adequate treatment approach has yet to be established, though many attempts have been undertaken. The current primary method for treatment is partial meniscectomy, which commonly results in the progressive development of osteoarthritis. This drawback has shifted research interest towards the fields of biomaterials and bioengineering, where it is hoped that meniscal deterioration can be tackled with the help of tissue engineering. So far, different approaches and strategies have contributed to the in vitro generation of meniscus constructs, which are capable of restoring meniscal lesions to some extent, both functionally as well as anatomically. The selection of the appropriate cell source (autologous, allogeneic, or xenogeneic cells, or stem cells) is undoubtedly regarded as key to successful meniscal tissue engineering. Furthermore, a large variation of scaffolds for tissue engineering have been proposed and produced in experimental and clinical studies, although a few problems with these (e.g., byproducts of degradation, stress shielding) have shifted research interest towards new strategies (e.g., scaffoldless approaches, self-assembly). A large number of different chemical (e.g., TGF-β1, C-ABC) and mechanical stimuli (e.g., direct compression, hydrostatic pressure) have also been investigated, both in terms of encouraging functional tissue formation, as well as in differentiating stem cells. Even though the problems accompanying meniscus tissue engineering research are considerable, we are undoubtedly in the dawn of a new era, whereby recent advances in biology, engineering, and medicine are leading to the successful treatment of meniscal lesions. PMID:21764438

Salivary markers of oxidative stress in oral diseases

PubMed Central

Tóthová, L'ubomíra; Kamodyová, Natália; Červenka, Tomáš; Celec, Peter

2015-01-01

Saliva is an interesting alternative diagnostic body fluid with several specific advantages over blood. These include non-invasive and easy collection and related possibility to do repeated sampling. One of the obstacles that hinders the wider use of saliva for diagnosis and monitoring of systemic diseases is its composition, which is affected by local oral status. However, this issue makes saliva very interesting for clinical biochemistry of oral diseases. Periodontitis, caries, oral precancerosis, and other local oral pathologies are associated with oxidative stress. Several markers of lipid peroxidation, protein oxidation and DNA damage induced by reactive oxygen species can be measured in saliva. Clinical studies have shown an association with oral pathologies at least for some of the established salivary markers of oxidative stress. This association is currently limited to the population level and none of the widely used markers can be applied for individual diagnostics. Oxidative stress seems to be of local oral origin, but it is currently unclear whether it is caused by an overproduction of reactive oxygen species due to inflammation or by the lack of antioxidants. Interventional studies, both, in experimental animals as well as humans indicate that antioxidant treatment could prevent or slow-down the progress of periodontitis. This makes the potential clinical use of salivary markers of oxidative stress even more attractive. This review summarizes basic information on the most commonly used salivary markers of oxidative damage, antioxidant status, and carbonyl stress and the studies analyzing these markers in patients with caries or periodontitis. PMID:26539412

Experimental simulation of gravity currents in erodible bed

NASA Astrophysics Data System (ADS)

Bateman, A.; La Roca, M.; Medina, V.

2009-04-01

Gravity currents are commonly met in nature, when a flow of denser fluid moves into a less dense one. A typical example of a gravity current is given by the sea water which flows into the bottom of a river during the summer, in correspondence of the estuary, when the river's discharge attains low values. In this case, dangerous consequences can occur, because of the polluting of the aquifer caused by the salty water. Density currents also occurs in lakes and reservoirs, because of a change in temperature or because a flood, both can produce some environmental impacts that are of interest to the local water Agency of the different countries. Of particular relevance is also the interaction of the gravity current with the movement of the sediments from the bottom of the bed. The international state of the art is particularly concerned with experimental and numerical investigation on gravity currents on fixed and porous bed [1-2-3], while, to the authors' knowledge, the interaction of a gravity current with an erodible bed is still an open field of investigation. In this paper experiments concerning with the propagation of a gravity current over fixed and erodible bed are presented. The experiments, conducted at the laboratory of Hydraulics of the Universitat Politecnica de Catalunya (actually in the Prof. Bateman's blue room), were concerned with a transparent tank 2 m long, 0.2 m wide and 0.3 m deep, partly filled with salty water and partly with fresh water, up to a depth of 0.28 m. The salty water, whose density was in the range 1050

A Model based Examination of Conditions for Ignition of Turbidity Currents on Slopes

NASA Astrophysics Data System (ADS)

Mehta, A. J.; Krishna, G.

2009-12-01

Turbidity currents form a major mechanism for the movement of sediment in the natural environment. Self-accelerating turbidity currents over continental slopes are of considerable scientific and engineering interest due to their role as agents for submarine sediment transportation from the shelf to the seabed. Such currents are called ignitive provided they eventually reach a catastrophic state as acceleration results in high sediment loads due to erosion of the sloping bed. A numerical model, which treats the fluid and the particles as two separate phases, is applied to investigate the effects of particle size, initial flow friction velocity and mild bed slope on the ignitive condition. Laboratory experimental data have been included as part of the analysis for qualitative comparison purposes. Ignition for the smallest of the three selected sizes (0.21mm) of medium sand typical of Florida beaches was found to depend on the initial conditions at the head of the slope as determined by the pressure gradient. Bed slope seemed to be of secondary importance. For the two sands with larger grain sizes (0.28mm and 0.35mm) the slope was found to play a more important role when compared to the initial pressure gradient. For a given pressure gradient, increasing the slope increased the likelihood of self-acceleration. It is concluded that in general ignition cannot be defined merely in terms of positive values of the velocity gradient and the sediment flux gradient along the slope. Depending on particle size the initial pressure gradient can also play a role. For the selected initial conditions (grain size, pressure gradient and bed slope), out of the 54 combinations tested, all except three satisfied the Knapp-Bagnold criterion for auto-suspension irrespective of whether the turbid current was ignitive or non-ignitive. In all 54 cases the current was found to erode the bed. Further use of the model will require accommodation of wider ranges of sediment size and bed density, and a thorough verification against experimental data.

Penobscot Experimental Forest: resources, administration, and mission

Treesearch

Alan J. Kimball

2014-01-01

The Penobscot Experimental Forest (PEF) was established more than 60 years ago as a result of private forest landowners' interest in supporting forest research in Maine. In 1950, nine pulp and paper and land-holding companies pooled resources and purchased almost 4,000 acres of land in east-central Maine. The property was named the Penobscot Experimental Forest...

Home-Career Conflict Reduction Revisited: The Effect of Experimental Directions on KOIS Scores for Women

ERIC Educational Resources Information Center

Tittle, Carol Kehr; Denker, Elenor Rubin

1976-01-01

The effect of experimental directions designed to reduce a home-career conflict in women's occupational choices on the Kuder Occupational Interest Survey was investigated. Results indicate that the validity of the Kuder survey is not compromised by the experimental directions. Tables are presented and implications are discussed. (Author/JKS)

Is News Media Related to Civic Engagement? The Effects of Interest in and Discussions about the News Media on Current and Future Civic Engagement of Adolescents

ERIC Educational Resources Information Center

Erentaite, Rasa; Zukauskiene, Rita; Beyers, Wim; Pilkauskaite-Valickiene, Rasa

2012-01-01

This study explored whether discussions about the media, when positively linked to interest in the news media, were related to adolescents' current and future civic engagement. A sample of 2638 adolescents (age M = 17, SD = 1.2), who participated in a school-based study on positive socialization, completed self-report measures on interest in the…

Current Events in Basic Business Education

ERIC Educational Resources Information Center

Van Hook, Barry L.

1974-01-01

The author suggests the use of current events to stimulate student interest in basic business courses. Suggested topics described are monetary devaluation, interest rate adjustments, Illinois no-fault automobile insurance, labor-management disputes, Dow-Jones average, Picasso's death, energy crisis, sale of surplus wheat, local consumer assistance…

What do we really know about conflicts of interest in biomedical research?

PubMed

Warner, Teddy D; Gluck, John P

2003-12-01

Conflicts of interest in research have long been seen to pose serious threats to the integrity of research. Indeed, the past two decades have revealed increased attention to the possible influence of conflicts of interest as the number of research studies funded by private industry have increased. We review empirical findings directly pertinent to issues concerning financial conflicts of interest in biomedical research, and we provide an overview of the current issues and state of understanding concerning such conflicts in research. We searched Medline from January 1992 to January 2002 to locate current studies that have reported primary or secondary empirical data pertaining to conflicts of interest in research. The rate of potential conflicts of interest for researchers appears to be at least 30% in some situations although the accuracy of such a rate is untested, and the rate of disclosure of conflicts of interest is as low as 2%. Furthermore, some evidence exists to indicate that researchers with conflicting interests may indeed offer different professional opinions and judgments than those for whom such conflicts do not exist. The effectiveness of various disclosure and management methods for conflicts of interest is unknown. We summarize the current empirical literature, concluding that relatively little is known based on such data. We suggest a number of questions that need to be answered by future research, and we offer recommendations for policy makers to consider and evaluate in the future in identifying, revealing, and managing conflicts of interest.

Electrical conductivity modeling and experimental study of densely packed SWCNT networks.

PubMed

Jack, D A; Yeh, C-S; Liang, Z; Li, S; Park, J G; Fielding, J C

2010-05-14

Single-walled carbon nanotube (SWCNT) networks have become a subject of interest due to their ability to support structural, thermal and electrical loadings, but to date their application has been hindered due, in large part, to the inability to model macroscopic responses in an industrial product with any reasonable confidence. This paper seeks to address the relationship between macroscale electrical conductivity and the nanostructure of a dense network composed of SWCNTs and presents a uniquely formulated physics-based computational model for electrical conductivity predictions. The proposed model incorporates physics-based stochastic parameters for the individual nanotubes to construct the nanostructure such as: an experimentally obtained orientation distribution function, experimentally derived length and diameter distributions, and assumed distributions of chirality and registry of individual CNTs. Case studies are presented to investigate the relationship between macroscale conductivity and nanostructured variations in the bulk stochastic length, diameter and orientation distributions. Simulation results correspond nicely with those available in the literature for case studies of conductivity versus length and conductivity versus diameter. In addition, predictions for the increasing anisotropy of the bulk conductivity as a function of the tube orientation distribution are in reasonable agreement with our experimental results. Examples are presented to demonstrate the importance of incorporating various stochastic characteristics in bulk conductivity predictions. Finally, a design consideration for industrial applications is discussed based on localized network power emission considerations and may lend insight to the design engineer to better predict network failure under high current loading applications.

Exercise genomics--a paradigm shift is needed: a commentary.

PubMed

Bouchard, Claude

2015-12-01

The overarching goal of exercise genomics is to illuminate exercise biology and behaviour in order to better understand the preventive and therapeutic values of exercise. An ancillary aim is to understand the role of genomic variation in human physical attributes and sports performance. The aim of this report is to briefly comment on the current status of exercise genetics and genomics and to suggest potential improvements to the research agenda and translational activities. First, the genomic features of interest to the biology of exercise are defined. Then, the limit of the current focus on common variants and their implications for exercise genomics is highlighted. The need for a major paradigm shift in exercise genomics research is discussed with an emphasis on study designs and appropriately powered studies as well as on more mechanistic and functional research. Finally, a summary of current practices in translational activities compared with what best practice demands is introduced. One suggestion is that the research portfolio of exercise genomics be composed of a larger fraction of experimental and mechanistic investigations and a smaller fraction of observational studies. It is also recommended that research should shift to unbiased exploration of the genome using all the power of genomics, epigenomics and transcriptomics in combination with large observational but preferably experimental study designs, including Mendelian randomisation. In all cases, emphasis on replications is of paramount importance. This represents an extraordinary challenge that can only be met with large-scale collaborative and multicentre research programmes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States.

PubMed

Ishchenko, Yevheniia; Novosolova, Nataliia; Khafizov, Kamil; Bart, Geneviève; Timonina, Arina; Fayuk, Dmitriy; Skorinkin, Andrei; Giniatullin, Rashid

2017-07-05

Serine 275, a conserved residue of the left flipper region of ATP-gated P2X3 receptors, plays a key role in both agonist binding and receptor desensitization. It is conserved in most of the P2X receptors except P2X7 and P2X6. By combining experimental patch-clamp and modeling approaches, we explored the role of the corresponding residue in the rat P2X7 receptor (rP2X7) by replacing the phenylalanine at position 288 with serine and characterizing the membrane currents generated by either the wild-type (WT) or the mutated rP2X7 receptor. F288S, an rP2X7 mutation, slowed the deactivation subsequent to 2 and 20 s applications of 1 mM ATP. F288S also prevented sensitization (a progressive current growth) observed with the WT in response to a 20 s application of 1 mM ATP. Increasing the ATP concentration to 5 mM promoted sensitization also in the mutated rP2X7 receptor, accelerating the deactivation rate to typical WT values. YO-PRO1 uptake in cells expressing either the WT or the F288S P2X7 receptor was consistent with recorded membrane current data. Interestingly, in the human P2X7 (hP2X7) receptor, substitution Y288S did not change the deactivation rate, while the Y288F mutant generated a "rat-like" phenotype with a fast deactivation rate. Our combined experimental, kinetic, and molecular modeling data suggest that the rat F288S novel phenotype is due to a slower rate of ATP binding and/or unbinding and stabilization of nonsensitized receptor states.

Combined electronic and thermodynamic approaches for enhancing the thermoelectric properties of Ti-doped PbTe.

PubMed

Komisarchik, G; Gelbstein, Y; Fuks, D

2016-11-30

Lead telluride based compounds are of great interest due to their enhanced thermoelectric transport properties. Nevertheless, the donor type impurities in this class of materials are currently mainly limited and alternative types of donor impurities are still required for optimizing the thermoelectric performance. In the current research titanium as a donor impurity in PbTe is examined. Although titanium is known to form resonant levels above the conduction band in PbTe, it does not enhance the thermo-power beyond the classical predictions. Recent experiments showed that alloying with a small amount of Ti (∼0.1 at%) gives a significant increase in the figure of merit. In the current research ab initio calculations were applied in order to correlate the reported experimental results with a thermoelectric optimization model. It was found that a Ti concentration of ∼1.4 at% in the Pb sublattice is expected to maximize the thermoelectric power factor. Using a statistical thermodynamic approach and in agreement with the previously reported appearance of a secondary intermetallic phase, the actual Ti solubility limit in PbTe is found to be ∼0.3 at%. Based on the proposed model, the mechanism for the formation of the previously observed secondary phase is attributed to phase separation reactions, characterized by a positive enthalpy of formation in the system. With extrapolation of the obtained ab initio results, it is demonstrated that lower Ti-doping concentrations than previously experimentally reported ones are expected to provide power factor values close to the maximal one, making doping with Ti a promising opportunity for the generation of highly efficient n-type PbTe-based thermoelectric materials.

Collective Poisson process with periodic rates: applications in physics from micro-to nanodevices.

PubMed

da Silva, Roberto; Lamb, Luis C; Wirth, Gilson Inacio

2011-01-28

Continuous reductions in the dimensions of semiconductor devices have led to an increasing number of noise sources, including random telegraph signals (RTS) due to the capture and emission of electrons by traps at random positions between oxide and semiconductor. The models traditionally used for microscopic devices become of limited validity in nano- and mesoscale systems since, in such systems, distributed quantities such as electron and trap densities, and concepts like electron mobility, become inadequate to model electrical behaviour. In addition, current experimental works have shown that RTS in semiconductor devices based on carbon nanotubes lead to giant current fluctuations. Therefore, the physics of this phenomenon and techniques to decrease the amplitudes of RTS need to be better understood. This problem can be described as a collective Poisson process under different, but time-independent, rates, τ(c) and τ(e), that control the capture and emission of electrons by traps distributed over the oxide. Thus, models that consider calculations performed under time-dependent periodic capture and emission rates should be of interest in order to model more efficient devices. We show a complete theoretical description of a model that is capable of showing a noise reduction of current fluctuations in the time domain, and a reduction of the power spectral density in the frequency domain, in semiconductor devices as predicted by previous experimental work. We do so through numerical integrations and a novel Monte Carlo Markov chain (MCMC) algorithm based on microscopic discrete values. The proposed model also handles the ballistic regime, relevant in nano- and mesoscale devices. Finally, we show that the ballistic regime leads to nonlinearity in the electrical behaviour.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkes, Douglas E.; Senor, David J.; Casella, Andrew M.

Numerous global programs are focused on the continued development of existing and new research and test reactor fuels to achieve maximum attainable uranium loadings to support the conversion of a number of the world’s remaining high-enriched uranium fueled reactors to low-enriched uranium fuel. Some of these programs are focused on development and qualification of a fuel design that consists of a uranium-molybdenum (U-Mo) alloy dispersed in an aluminum matrix as one option for reactor conversion. The current paper extends a failure model originally developed for UO2-stainless steel dispersion fuels and used currently available thermal-mechanical property information for the materials ofmore » interest in the current proposed design. A number of fabrication and irradiation parameters were investigated to understand the conditions at which failure of the matrix, classified as pore formation in the matrix, might occur. The results compared well with experimental observations published as part of the Reduced Enrichment for Research and Test Reactors (RERTR)-6 and -7 mini-plate experiments. Fission rate, a function of the 235U enrichment, appeared to be the most influential parameter in premature failure, mainly as a result of increased interaction layer formation and operational temperature, which coincidentally decreased the yield strength of the matrix and caused more rapid fission gas production and recoil into the surrounding matrix material. Addition of silicon to the matrix appeared effective at reducing the rate of interaction layer formation and can extend the performance of a fuel plate under a certain set of irradiation conditions, primarily moderate heat flux and burnup. Increasing the dispersed fuel particle diameter may also be effective, but only when combined with other parameters, e.g., lower enrichment and increased Si concentration. The model may serve as a valuable tool in initial experimental design.« less

An experimental investigation on liquid methane heat transfer enhancement through the use of longitudinal fins in cooling channels

NASA Astrophysics Data System (ADS)

Galvan, Manuel de Jesus

In the past years, hydrocarbon fuels have been the focus of attention as the interest in developing reusable, high-performing liquid rocket engines has grown. Liquid methane (LCH4) has been of particular interest because of the cost, handling, and storage advantages that it presents when compared to currently used propellants. Deep space exploration requires thrusters that can operate reliably during long-duration missions. One of the challenges in the development of a reliable engine has been providing adequate combustion chamber cooling to prevent engine failure. Regenerative (regen) cooling has presented itself as an appealing option because it provides improved cooling and engine efficiency over other types of cooling, such as film or dump cooling. Due to limited availability of experimental sub-critical liquid methane cooling data for pressure-fed regen engine design, there has been an interest in studying the heat transfer characteristics of the propellant. For this reason, recent experimental studies at the Center for Space Exploration Technology Research (cSETR) at the University of Texas at El Paso (UTEP) have focused on investigating the heat transfer characteristics of sub-critical CH4 flowing through smooth sub-scale cooling channels. In addition to investigating smooth channels, the cSETR has conducted experiments to investigate the effects of internal longitudinal fins on the heat transfer of methane. To conduct the experiments, the cSETR developed a conduction-based thermal concentrator known as the High Heat Flux Test Facility (HHFTF) in which the channels are heated. In this study, a smooth channel and three channels with longitudinal fins all with cross sectional geometries of 3.2 mm x 3.2 mm were tested. The Nusselt numbers ranged from 70 and 510, and Reynolds numbers were between 50,000 and 128,000. Sub-cooled film-boiling phenomena were discovered in the data pertaining to the smooth and two finned channels. Sub-cooled film-boiling was not observed in the channel that had the fins with the highest height. Film-boiling onset at Critical Heat Flux (CHF) was correlated to a Boiling Number (Bo) of approximately 0.1 for the channels studies. Convective Nusselt number follows predicted trends for Reynolds number with a wall temperature correction factor for both the boiling and non-boiling regimes.

Structural determination of nanomolar quantities of neuroactive peptides by nuclear magnetic resonance

NASA Astrophysics Data System (ADS)

Matei, Elena

The specificity of the conotoxin is one of the attributes that make them a valuable diagnostic tool in the characterization of neuronal mechanisms, or therapeutic agents in medicine. It appears that Nature has provided us with a pharmaceutical tool in the form of Conus peptides. Further studies will only enhance our understanding, and use, of these molecules in medicine and science. The study of three-dimensional structure in relation to the function of cone snail peptides is an area of increasing interest. The venom of a single cone snail can contain as many as 300 different chemical components. Individual cone snail venom components, or conopeptides, can have powerful neurological effects. For many interesting species, not enough venom collected from the natural origin is available for experimental investigations. After a laborious separation procedure, only nanomole quantities of these native conopeptides are able to be obtained. Therefore, several experimental applications, such as NMR spectroscopy, are difficult to carry out using traditional methods. The research was focused on using nanoNMR spectroscopy as an alternative method to the conventional NMR spectroscopy method in order to analyze small quantities of novel peptides with unknown three-dimensional conformational arrangement. The experimental results obtained using the HR-MAS NMR technique, in addition to the use of a 3mm gHCN (with 1.7mm inserts) NMR probes, proved the capability of conformational analysis of different types of natural products at sample levels down to nanomole range. Understanding the interaction between agonist or antagonist ligands and their target receptors, at a molecular level, offer promise for the development of pharmacological therapeutics for the central nervous system. Conopeptides are of great interest as ligands in neuroscience and are valuable leads in drug design, based on their specificity and potency for therapeutically relevant receptors and ion channels. For instance, the compound called Prialt (formerly known as Ziconotide), a synthetic form of a cone snail-derived peptide, is the most powerful painkiller known and has already received the Food and Drug Administration (FDA) approval. The drug is part of a new class known as the N-type calcium channel blockers, which are responsible for transmitting pain signals. Several related cone snail drugs are currently in clinical trials and could eventually be used to treat different diseases such as Alzheimer's, epilepsy and Parkinson's.

Challenges for the Modern Science in its Descend Towards Nano Scale

PubMed Central

Uskoković, Vuk

2013-01-01

The current rise in the interest in physical phenomena at nano spatial scale is described hereby as a natural consequence of the scientific progress in manipulation with matter with an ever higher sensitivity. The reason behind arising of the entirely new field of nanoscience is that the properties of nanostructured materials may significantly differ from their bulk counterparts and cannot be predicted by extrapolations of the size-dependent properties displayed by materials composed of microsized particles. It is also argued that although a material can comprise critical boundaries at the nano scale, this does not mean that it will inevitably exhibit properties that endow a nanomaterial. This implies that the attribute of “nanomaterial” can be used only in relation with a given property of interest. The major challenges faced with the expansion of resolution of the materials design, in terms of hardly reproducible experiments, are further discussed. It is claimed that owing to an unavoidable interference between the experimental system and its environment to which the controlling system belongs, an increased fineness of the experimental settings will lead to ever more difficulties in rendering them reproducible and controllable. Self-assembly methods in which a part of the preprogrammed scientific design is substituted with letting physical systems spontaneously evolve into attractive and functional structures is mentioned as one of the ways to overcome the problems inherent in synthetic approaches at the ultrafine scale. The fact that physical systems partly owe their properties to the interaction with their environment implies that each self-assembly process can be considered a co-assembly event. PMID:26491428

Molecular simulations of self-assembly processes in metal-organic frameworks: Model dependence

NASA Astrophysics Data System (ADS)

Biswal, Debasmita; Kusalik, Peter G.

2017-07-01

Molecular simulation is a powerful tool for investigating microscopic behavior in various chemical systems, where the use of suitable models is critical to successfully reproduce the structural and dynamic properties of the real systems of interest. In this context, molecular dynamics simulation studies of self-assembly processes in metal-organic frameworks (MOFs), a well-known class of porous materials with interesting chemical and physical properties, are relatively challenging, where a reasonably accurate representation of metal-ligand interactions is anticipated to play an important role. In the current study, we both investigate the performance of some existing models and introduce and test new models to help explore the self-assembly in an archetypal Zn-carboxylate MOF system. To this end, the behavior of six different Zn-ion models, three solvent models, and two ligand models was examined and validated against key experimental structural parameters. To explore longer time scale ordering events during MOF self-assembly via explicit solvent simulations, it is necessary to identify a suitable combination of simplified model components representing metal ions, organic ligands, and solvent molecules. It was observed that an extended cationic dummy atom (ECDA) Zn-ion model combined with an all-atom carboxylate ligand model and a simple dipolar solvent model can reproduce characteristic experimental structures for the archetypal MOF system. The successful use of these models in extensive sets of molecular simulations, which provide key insights into the self-assembly mechanism of this archetypal MOF system occurring during the early stages of this process, has been very recently reported.

Health promotion and patient education benefits for employees.

PubMed

Mullen, P D

1988-01-01

One step that employers can take to assure that employees receive such education services is pursuing coverage of education as a separate service. For some time now, insurers have shown interest in patient education services (15-17, 61), but patient education "integral to care" is typically covered only as a part of the "per diem" in the case of hospitals or as part of the visit fee in the case of outpatient visits. Education for patients with diabetes is being covered experimentally as a separate service in at least 17 states. Physicians whose practice is composed largely of "cognitive services" rather than "procedures" are also interested in education as a reimbursable service. The same arguments as described in relation to coverage of risk reduction services generally apply to this case. Education programs for employees who are under medical care can improve their adherence to the recommended regimen and hence can improve the effectiveness of care. Education and counseling prior to surgical and other stressful procedures decrease stress and the need for pain medications, and they can shorten the length of hospital stays. Education is an important component of programs to substitute home care for hospital care or expensive outpatient care. Currently, however, a patient cannot rely on usual providers of medical care to offer adequate education. Reimbursement for patient education on a selected, experimental basis is probably warranted for chronic conditions requiring complex adjustments and regimens. Cases of asthma where there is a history of hospitalization or emergency room visits is an excellent possibility. The experience of covering diabetes education should be monitored to help resolve the debate.

The Mysterious Universe - Exploring Our World with Particle Accelerators

ScienceCinema

Brau, James E [University of Oregon

2018-04-24

The universe is dark and mysterious, more so than even Einstein imagined. While modern science has established deep understanding of ordinary matter, unidentified elements ("Dark Matter" and "Dark Energy") dominate the structure of the universe, its behavior and its destiny. What are these curious elements? We are now working on answers to these and other challenging questions posed by the universe with experiments at particle accelerators on Earth. Results of this research may revolutionize our view of nature as dramatically as the advances of Einstein and other quantum pioneers one hundred years ago. Professor Brau will explain for the general audience the mysteries, introduce facilities which explore them experimentally and discuss our current understanding of the underlying science. The presentation is at an introductory level, appropriate for anyone interested in physics and astronomy.

Hypersonic propulsion: Status and challenge

NASA Technical Reports Server (NTRS)

Guy, R. Wayne

1990-01-01

Scientists in the U.S. are again focusing on the challenge of hypersonic flight with the proposed National Aerospace Plane (NASP). This renewed interest has led to an expansion of research related to high speed airbreathing propulsion, in particular, the supersonic combustion ramjet, or scramjet. The history is briefly traced of scramjet research in the U.S., with emphasis on NASA sponsored efforts, from the Hypersonic Research Engine (HRE) to the current status of today's airframe integrated scramjets. The challenges of scramjet technology development from takeover to orbital speeds are outlined. Existing scramjet test facilities such as NASA Langley's Scramjet Test Complex as well as new high Mach number pulse facilities are discussed. The important partnership role of experimental methods and computational fluid dynamics is emphasized for the successful design of single stage to orbit vehicles.

The Search for the Pentaquark

NASA Astrophysics Data System (ADS)

Eyrich, Wolfgang

2007-01-01

In the last two years, starting with the LEPS collaboration1 several experiments reported evidence for a manifestly exotic narrow state with a mass of about 1530 MeV/c2. The state was found to decay into K0p and K+n. This object with strangeness S = +1 was named Θ+ and identified with the lightest exotic antidecuplet baryon predicted in the soliton model2. Many experiments have scanned their data for a pentaquark signal with varying results. Some searches resulted in evidence for the Θ+ while others fail to produce any narrow structure in the region of interest. Currently, a number of high statistics experiments are being evaluated with the goal to confirm or refute the existence of the Θ+. In this contribution the experimental status and further prospects will be discussed.

Genome and proteome annotation: organization, interpretation and integration

PubMed Central

Reeves, Gabrielle A.; Talavera, David; Thornton, Janet M.

2008-01-01

Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the means to disseminate these data and to comprehend their biological importance. This review examines the various aspects of annotation: type, methodology and availability. Moreover, it puts a special interest on novel annotation fields, such as that of phenotypes, and highlights the recent efforts focused on the integrating annotations. PMID:19019817

High-intensity focused ultrasound in obstetrics and gynecology: the birth of a new era of noninvasive surgery?

PubMed

Griffiths, A; terHaar, G; Rivens, I; Giussani, D; Lees, C

2012-12-01

Although ultrasound is an essential investigative modality in obstetrics and gynecology, the potential for therapeutic high-intensity focused ultrasound (HIFU) (also referred to as focused ultrasound surgery, FUS) to offer an alternative to invasive surgery is less well known. The ability of HIFU to create discrete regions of tissue necrosis only in precisely targeted positions by careful placement of the focus, without the need for any surgical intervention, has made HIFU of interest to those seeking noninvasive alternatives to conventional abdominal surgery. This article reviews the current experimental and clinical experience with HIFU in obstetrics and gynecology, and outlines potential future applications in fetal medicine and the challenges faced in their development. © Georg Thieme Verlag KG Stuttgart · New York.

Chronic Lowering of Blood Pressure by Carotid Baroreflex Activation: Mechanisms and Potential for Hypertension Therapy

PubMed Central

Lohmeier, Thomas E.; Iliescu, Radu

2011-01-01

Recent technical advances have renewed interest in device-based therapy for the treatment of drug-resistant hypertension. Findings from recent clinical trials regarding the efficacy of electrical stimulation of the carotid sinus for the treatment of resistant hypertension are reviewed here. The main goal of this article, however, is to summarize the preclinical studies that have provided insight into the mechanisms that account for the chronic blood pressure lowering effects of carotid baroreflex activation. Some of the mechanisms identified were predictable and confirmed by experimentation. Others have been surprising and controversial and resolution will require further investigation. Although feasibility studies have been promising, firm conclusions regarding the value of this device-based therapy for the treatment of resistant hypertension awaits the results of current multicenter trials. PMID:21357283

Measurement and calculation of levitation forces between magnets and granular superconductors

NASA Technical Reports Server (NTRS)

Johansen, T. H.; Bratsberg, H.; Baziljevich, M.; Hetland, P. O.; Riise, A. B.

1995-01-01

Recent developments indicate that exploitation of the phenomenon of magnetic levitation may become one of the most important near-term applications of high-T(sub c) superconductivity. Because of this, the interaction between a strong permanent magnet(PM) and bulk high-T(sub c) superconductor (HTSC) is currently a subject of much interest. We have studied central features of the mechanics of PM-HTSC systems of simple geometries. Here we report experimental results for the components of the levitation force, their associated stiffness and mechanical ac-loss. To analyze the observed behavior a theoretical framework based on critical-state considerations is developed. It will be shown that all the mechanical properties can be explained consistently at a quantitative level wing a minimum of model parameters.

The use of acoustically tuned resonators to improve the sound transmission loss of double-panel partitions

NASA Astrophysics Data System (ADS)

Mason, J. M.; Fahy, F. J.

1988-07-01

Double-leaf partitions are often utilized in situations requiring low weight structures with high transmission loss, an example of current interest being the fuselage walls of propeller-driven aircraft. In this case, acoustic excitation is periodic and, if one of the frequencies of excitation lies in the region of the fundamental mass-air-mass frequency of the partition, insulation performance is considerably less than desired. The potential effectiveness of tuned Helmholtz resonators connected to the partition cavity is investigated as a method of improving transmission loss. This is demonstrated by a simple theoretical model and then experimentally verified. Results show that substantial improvements may be obtained at and around the mass-air-mass frequency for a total resonator volume 15 percent of the cavity volume.

40 CFR 35.6340 - Disposal of CERCLA-funded property.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund... Substance Superfund for EPA's vested interest in the current fair market value of the equipment at the time... supplies and reimburse the Hazardous Substance Superfund for EPA's interest in the current fair market...

36 CFR 1250.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requester seeking information for a use or purpose that furthers the commercial, trade, or profit interests... professional education, or an institution of vocational education, that operates a program of scholarly... information that is about current events or that would be of current interest to the public. Examples of news...

48 CFR 52.232-12 - Advance Payments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... subcontractors for experimental, developmental, or research work. (3) If interest is required under the contract... each request for advance payments is true and correct. (8) These representations shall be continuing... nonprofit educational or research subcontractors for experimental, developmental, or research work...

48 CFR 52.232-12 - Advance Payments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... subcontractors for experimental, developmental, or research work. (3) If interest is required under the contract... each request for advance payments is true and correct. (8) These representations shall be continuing... nonprofit educational or research subcontractors for experimental, developmental, or research work...

48 CFR 52.232-12 - Advance Payments.

Code of Federal Regulations, 2012 CFR

2012-10-01

... subcontractors for experimental, developmental, or research work. (3) If interest is required under the contract... each request for advance payments is true and correct. (8) These representations shall be continuing... nonprofit educational or research subcontractors for experimental, developmental, or research work...

48 CFR 52.232-12 - Advance Payments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... subcontractors for experimental, developmental, or research work. (3) If interest is required under the contract... each request for advance payments is true and correct. (8) These representations shall be continuing... nonprofit educational or research subcontractors for experimental, developmental, or research work...

48 CFR 52.232-12 - Advance Payments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... subcontractors for experimental, developmental, or research work. (3) If interest is required under the contract... each request for advance payments is true and correct. (8) These representations shall be continuing... nonprofit educational or research subcontractors for experimental, developmental, or research work...

Theoretical and experimental approaches to possible thresholds of response in carcinogenicity

EPA Science Inventory

The determination and utilization of the actual low dose-response relationship for chemical carcinogens has long interested toxicologists, experimental pathologists, modelers and risk assessors. To date, no unequivocal examples of carcinogenic thresholds in humans are known. Ho...

Bibliotherapy: Medicine for the Soul?

ERIC Educational Resources Information Center

Stevens, Michael J.; Pfost, Karen S.

1982-01-01

Reviews research on bibliotherapy in an attempt to find scientific justification for its use. An overview of the experimental research conveys a generally unfavorable picture of its effectiveness. Guidelines for future research suggest the experimental manipulation of specific variables of interest. (Author/JAC)

Virtual Reality for Enhanced Ecological Validity and Experimental Control in the Clinical, Affective and Social Neurosciences

PubMed Central

Parsons, Thomas D.

2015-01-01

An essential tension can be found between researchers interested in ecological validity and those concerned with maintaining experimental control. Research in the human neurosciences often involves the use of simple and static stimuli lacking many of the potentially important aspects of real world activities and interactions. While this research is valuable, there is a growing interest in the human neurosciences to use cues about target states in the real world via multimodal scenarios that involve visual, semantic, and prosodic information. These scenarios should include dynamic stimuli presented concurrently or serially in a manner that allows researchers to assess the integrative processes carried out by perceivers over time. Furthermore, there is growing interest in contextually embedded stimuli that can constrain participant interpretations of cues about a target’s internal states. Virtual reality environments proffer assessment paradigms that combine the experimental control of laboratory measures with emotionally engaging background narratives to enhance affective experience and social interactions. The present review highlights the potential of virtual reality environments for enhanced ecological validity in the clinical, affective, and social neurosciences. PMID:26696869

Virtual Reality for Enhanced Ecological Validity and Experimental Control in the Clinical, Affective and Social Neurosciences.

PubMed

Parsons, Thomas D

2015-01-01

An essential tension can be found between researchers interested in ecological validity and those concerned with maintaining experimental control. Research in the human neurosciences often involves the use of simple and static stimuli lacking many of the potentially important aspects of real world activities and interactions. While this research is valuable, there is a growing interest in the human neurosciences to use cues about target states in the real world via multimodal scenarios that involve visual, semantic, and prosodic information. These scenarios should include dynamic stimuli presented concurrently or serially in a manner that allows researchers to assess the integrative processes carried out by perceivers over time. Furthermore, there is growing interest in contextually embedded stimuli that can constrain participant interpretations of cues about a target's internal states. Virtual reality environments proffer assessment paradigms that combine the experimental control of laboratory measures with emotionally engaging background narratives to enhance affective experience and social interactions. The present review highlights the potential of virtual reality environments for enhanced ecological validity in the clinical, affective, and social neurosciences.

International Shock-Wave Database: Current Status

NASA Astrophysics Data System (ADS)

Levashov, Pavel

2013-06-01

Shock-wave and related dynamic material response data serve for calibrating, validating, and improving material models over very broad regions of the pressure-temperature-density phase space. Since the middle of the 20th century vast amount of shock-wave experimental information has been obtained. To systemize it a number of compendiums of shock-wave data has been issued by LLNL, LANL (USA), CEA (France), IPCP and VNIIEF (Russia). In mid-90th the drawbacks of the paper handbooks became obvious, so the first version of the online shock-wave database appeared in 1997 (http://www.ficp.ac.ru/rusbank). It includes approximately 20000 experimental points on shock compression, adiabatic expansion, measurements of sound velocity behind the shock front and free-surface-velocity for more than 650 substances. This is still a useful tool for the shock-wave community, but it has a number of serious disadvantages which can't be easily eliminated: (i) very simple data format for points and references; (ii) minimalistic user interface for data addition; (iii) absence of history of changes; (iv) bad feedback from users. The new International Shock-Wave database (ISWdb) is intended to solve these and some other problems. The ISWdb project objectives are: (i) to develop a database on thermodynamic and mechanical properties of materials under conditions of shock-wave and other dynamic loadings, selected related quantities of interest, and the meta-data that describes the provenance of the measurements and material models; and (ii) to make this database available internationally through the Internet, in an interactive form. The development and operation of the ISWdb is guided by an advisory committee. The database will be installed on two mirrored web-servers, one in Russia and the other in USA (currently only one server is available). The database provides access to original experimental data on shock compression, non-shock dynamic loadings, isentropic expansion, measurements of sound speed in the Hugoniot state, and time-dependent free-surface or window-interface velocity profiles. Users are able to search the information in the database and obtain the experimental points in tabular or plain text formats directly via the Internet using common browsers. It is also possible to plot the experimental points for comparison with different approximations and results of equation-of-state calculations. The user can present the results of calculations in text or graphical forms and compare them with any experimental data available in the database. A short history of the shock-wave database will be presented and current possibilities of ISWdb will be demonstrated. Web-site of the project: http://iswdb.info. This work is supported by SNL contracts # 1143875, 1196352.

Social Interest in High-Functioning Adults with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Fletcher-Watson, Sue; Leekam, Susan R.; Findlay, John M.

2013-01-01

Autism spectrum disorders (ASD) are principally characterized by impairments in social functioning. Experimental investigation often is conducted using methods measuring social attention, social cognition, and social communication. In this study, we instead measured interest in social information, making a distinction between basic-level…

Data Analysis Strategies for Quasi-Experimental Studies Where Differential Group and Individual Growth Rates Are Assumed. Research Series No. 13.

ERIC Educational Resources Information Center

Olejnik, Stephen

The measurement of change in quasi-experimental educational research was discussed. Problems related to measuring change exist to varying degrees in all research designs; these issues are less troublesome in experimental studies because the investigator can manipulate the interest variables and observe their effects on other variables. Measuring…

Emotion-Related Regulation: An Emerging Construct

ERIC Educational Resources Information Center

Eisenberg, Nancy; Champion, Claire; Ma, Yue

2004-01-01

Emotion-related regulation is a topic of considerable current interest; however, this was not always true. We briefly discuss the history of interest in the topic and then the current state of the field, including definitions of the construct. In addition, we summarize some of the important issues for future attention, including definitional…

Dynamic root distributions in ecohydrological modeling: A case study at Walnut Gulch Experimental Watershed

NASA Astrophysics Data System (ADS)

Sivandran, Gajan; Bras, Rafael L.

2013-06-01

Arid regions are characterized by high variability in the arrival of rainfall, and species found in these areas have adapted mechanisms to ensure the capture of this scarce resource. In particular, the rooting strategies employed by vegetation can be critical to their survival. However, land surface models currently prescribe rooting profiles as a function of only the plant functional type of interest with no consideration for the soil texture or rainfall regime of the region being modeled. Additionally, these models do not incorporate the ability of vegetation to dynamically alter their rooting strategies in response to transient changes in environmental forcings or competition from other plant species and therefore tend to underestimate the resilience of these ecosystems. To address the simplicity of the current representation of roots in land surface models, a new dynamic rooting scheme was incorporated into the framework of the distributed ecohydrological model tRIBS+VEGGIE. The new scheme optimizes the allocation of carbon to the root zone to reduce the perceived stress of the vegetation, so that root profiles evolve based upon local climate and soil conditions. The ability of the new scheme to capture the complex dynamics of natural systems was evaluated by comparisons to hourly timescale energy flux, soil moisture, and vegetation growth observations from the Walnut Gulch Experimental Watershed, Arizona. Robust agreement was found between the model and observations, providing confidence that the improved model is able to capture the multidirectional interactions between climate, soil, and vegetation at this site.

Theoretical and experimental studies in support of the geophysical fluid flow experiment

NASA Technical Reports Server (NTRS)

Hart, J.; Toomre, J.

1985-01-01

Meteorologists and astrophysicists interested in large scale planetary and solar circulations have come to recognize the importance of rotation and stratification in determining the character of these flows. In particular, the effect of latitude-dependent Coriolis force on nonlinear convection is thought to play a crucial role in such phenomena as differential rotation on the Sun, cloud band orientation on Jupiter, and the generation of magnetic fields in thermally driven dynamos. The continuous low-gravity environment of the orbiting space shuttle offers a unique opportunity to make laboratory studies of such large-scale thermally driven flows under the constraint imposed by rotation and sphericity. This is possible because polarization forces in a dielectric liquid, which are linearly dependent on fluid temperature, give rise to an effectively radial buoyancy force when a radial electrostatic field is imposed. The Geophysical Fluid Flow Cell (GFFC) is an implementation of this ideal in which fluid is contained between two rotating hemispheres that are differentially heated and stressed with a large a-c voltage. The experiment, to be flown on Spacelab III (currently set for launch April 29, 1985), will explore non-linear mode selection and high Rayleigh number turbulence in a rotating convecting spherical shell of liquid. Experiments will be carried out in a low driving parameter range where some limited numerical experimentation is currently feasible, as well as in a parameter range significantly beyond numerical computation for many years.

Spallation neutron production and the current intra-nuclear cascade and transport codes

NASA Astrophysics Data System (ADS)

Filges, D.; Goldenbaum, F.; Enke, M.; Galin, J.; Herbach, C.-M.; Hilscher, D.; Jahnke, U.; Letourneau, A.; Lott, B.; Neef, R.-D.; Nünighoff, K.; Paul, N.; Péghaire, A.; Pienkowski, L.; Schaal, H.; Schröder, U.; Sterzenbach, G.; Tietze, A.; Tishchenko, V.; Toke, J.; Wohlmuther, M.

A recent renascent interest in energetic proton-induced production of neutrons originates largely from the inception of projects for target stations of intense spallation neutron sources, like the planned European Spallation Source (ESS), accelerator-driven nuclear reactors, nuclear waste transmutation, and also from the application for radioactive beams. In the framework of such a neutron production, of major importance is the search for ways for the most efficient conversion of the primary beam energy into neutron production. Although the issue has been quite successfully addressed experimentally by varying the incident proton energy for various target materials and by covering a huge collection of different target geometries --providing an exhaustive matrix of benchmark data-- the ultimate challenge is to increase the predictive power of transport codes currently on the market. To scrutinize these codes, calculations of reaction cross-sections, hadronic interaction lengths, average neutron multiplicities, neutron multiplicity and energy distributions, and the development of hadronic showers are confronted with recent experimental data of the NESSI collaboration. Program packages like HERMES, LCS or MCNPX master the prevision of reaction cross-sections, hadronic interaction lengths, averaged neutron multiplicities and neutron multiplicity distributions in thick and thin targets for a wide spectrum of incident proton energies, geometrical shapes and materials of the target generally within less than 10% deviation, while production cross-section measurements for light charged particles on thin targets point out that appreciable distinctions exist within these models.

Magnetism in olivine-type LiCo(1-x)Fe(x)PO4 cathode materials: bridging theory and experiment.

PubMed

Singh, Vijay; Gershinsky, Yelena; Kosa, Monica; Dixit, Mudit; Zitoun, David; Major, Dan Thomas

2015-12-14

In the current paper, we present a non-aqueous sol-gel synthesis of olivine type LiCo1-xFexPO4 compounds (x = 0.00, 0.25, 0.50, 0.75, 1.00). The magnetic properties of the olivines are measured experimentally and calculated using first-principles theory. Specifically, the electronic and magnetic properties are studied in detail with standard density functional theory (DFT), as well as by including spin-orbit coupling (SOC), which couples the spin to the crystal structure. We find that the Co(2+) ions exhibit strong orbital moment in the pure LiCoPO4 system, which is partially quenched upon substitution of Co(2+) by Fe(2+). Interestingly, we also observe a non-negligible orbital moment on the Fe(2+) ion. We underscore that the inclusion of SOC in the calculations is essential to obtain qualitative agreement with the observed effective magnetic moments. Additionally, Wannier functions were used to understand the experimentally observed rising trend in the Néel temperature, which is directly related to the magnetic exchange interaction paths in the materials. We suggest that out of layer M-O-P-O-M magnetic interactions (J⊥) are present in the studied materials. The current findings shed light on important differences observed in the electrochemistry of the cathode material LiCoPO4 compared to the already mature olivine material LiFePO4.

Elastic suspension of a wind tunnel test section

NASA Technical Reports Server (NTRS)

Hacker, R.; Rock, S.; Debra, D. B.

1982-01-01

Experimental verification of the theory describing arbitrary motions of an airfoil is reported. The experimental apparatus is described. A mechanism was designed to provide two separate degrees of freedom without friction or backlash to mask the small but important aerodynamic effects of interest.

Ab initio calculation of the potential bubble nucleus 34Si

NASA Astrophysics Data System (ADS)

Duguet, T.; Somà, V.; Lecluse, S.; Barbieri, C.; Navrátil, P.

2017-03-01

Background: The possibility that an unconventional depletion (referred to as a "bubble") occurs in the center of the charge density distribution of certain nuclei due to a purely quantum mechanical effect has attracted theoretical and experimental attention in recent years. Based on a mean-field rationale, a correlation between the occurrence of such a semibubble and an anomalously weak splitting between low angular-momentum spin-orbit partners has been further conjectured. Energy density functional and valence-space shell model calculations have been performed to identify and characterize the best candidates, among which 34Si appears as a particularly interesting case. While the experimental determination of the charge density distribution of the unstable 34Si is currently out of reach, (d ,p ) experiments on this nucleus have been performed recently to test the correlation between the presence of a bubble and an anomalously weak 1 /2--3 /2- splitting in the spectrum of 35Si as compared to 37S. Purpose: We study the potential bubble structure of 34Si on the basis of the state-of-the-art ab initio self-consistent Green's function many-body method. Methods: We perform the first ab initio calculations of 34Si and 36S. In addition to binding energies, the first observables of interest are the charge density distribution and the charge root-mean-square radius for which experimental data exist in 36S. The next observable of interest is the low-lying spectroscopy of 35Si and 37S obtained from (d ,p ) experiments along with the spectroscopy of 33Al and 35P obtained from knock-out experiments. The interpretation in terms of the evolution of the underlying shell structure is also provided. The study is repeated using several chiral effective field theory Hamiltonians as a way to test the robustness of the results with respect to input internucleon interactions. The convergence of the results with respect to the truncation of the many-body expansion, i.e., with respect to the many-body correlations included in the calculation, is studied in detail. We eventually compare our predictions to state-of-the-art multireference energy density functional and shell model calculations. Results: The prediction regarding the (non)existence of the bubble structure in 34Si varies significantly with the nuclear Hamiltonian used. However, demanding that the experimental charge density distribution and the root-mean-square radius of 36S be well reproduced, along with 34Si and 36S binding energies, only leaves the NNLOsat Hamiltonian as a serious candidate to perform this prediction. In this context, a bubble structure, whose fingerprint should be visible in an electron scattering experiment of 34Si, is predicted. Furthermore, a clear correlation is established between the occurrence of the bubble structure and the weakening of the 1 /2--3 /2- splitting in the spectrum of 35Si as compared to 37S. Conclusions: The occurrence of a bubble structure in the charge distribution of 34Si is convincingly established on the basis of state-of-the-art ab initio calculations. This prediction will have to be reexamined in the future when improved chiral nuclear Hamiltonians are constructed. On the experimental side, present results act as a strong motivation to measure the charge density distribution of 34Si in future electron scattering experiments on unstable nuclei. In the meantime, it is of interest to perform one-neutron removal on 34Si and 36S in order to further test our theoretical spectral strength distributions over a wide energy range.

29 CFR 20.58 - Rate of interest.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Rate of interest. 20.58 Section 20.58 Labor Office of the Secretary of Labor FEDERAL CLAIMS COLLECTION Interest, Penalties and Administrative Costs § 20.58 Rate of interest. (a) The rate of interest assessed shall be the rate of the current value of funds to the United...

Experimental setup for the measurement of induction motor cage currents

NASA Astrophysics Data System (ADS)

Bottauscio, Oriano; Chiampi, Mario; Donadio, Lorenzo; Zucca, Mauro

2005-04-01

An experimental setup for measurement of the currents flowing in the rotor bars of induction motors during synchronous no-load tests is described in the paper. The experimental verification of the high-frequency phenomena in the rotor cage is fundamental for a deep insight of the additional loss estimation by numerical methods. The attention is mainly focused on the analysis and design of the transducers developed for the cage current measurement.

Experimental investigation of efficient locomotion of underwater snake robots for lateral undulation and eel-like motion patterns.

PubMed

Kelasidi, Eleni; Liljebäck, Pål; Pettersen, Kristin Y; Gravdahl, Jan T

2015-01-01

Underwater snake robots offer many interesting capabilities for underwater operations. The long and slender structure of such robots provide superior capabilities for access through narrow openings and within confined areas. This is interesting for inspection and monitoring operations, for instance within the subsea oil and gas industry and within marine archeology. In addition, underwater snake robots can provide both inspection and intervention capabilities and are thus interesting candidates for the next generation inspection and intervention AUVs. Furthermore, bioinspired locomotion through oscillatory gaits, like lateral undulation and eel-like motion, is interesting from an energy efficiency point of view. Increasing the motion efficiency in terms of the achieved forward speed by improving the method of propulsion is a key issue for underwater robots. Moreover, energy efficiency is one of the main challenges for long-term autonomy of these systems. In this study, we will consider both these two aspects of efficiency. This paper considers the energy efficiency of swimming snake robots by presenting and experimentally investigating fundamental properties of the velocity and the power consumption of an underwater snake robot for both lateral undulation and eel-like motion patterns. In particular, we investigate the relationship between the parameters of the gait patterns, the forward velocity and the energy consumption for different motion patterns. The simulation and experimental results are seen to support the theoretical findings.

Gender, values, and occupational interests among children, adolescents, and adults.

PubMed

Weisgram, Erica S; Bigler, Rebecca S; Liben, Lynn S

2010-01-01

Work fulfills personal values, perhaps differently for males and females. Explored here was the role values play in shaping occupational interests. Study 1 examined children's, adolescents', and adults' (N = 313) occupational values (regarding money, power, family, altruism), occupational interests, and perceptions of values afforded by traditionally masculine and feminine occupations. Results revealed sex differences in occupational values and interests. Furthermore, participants' values predicted their own interests in culturally masculine and feminine occupations. Study 2 used novel jobs and experimentally manipulated prototypical sex of worker and value affordances to disentangle their effects on occupational interests. At all ages, participants' (N = 240) occupational interests were affected by the depicted sex of the workers and by the stated value affordances of the jobs.

REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry

Caltech High Energy Physics (HEP) has a broad program in both experimental and theoretical physics. We are known for our creativity and leadership. The future is uncertain and we strive to be involved in all the major areas of experimental and theoretical HEP physics so no matter where the important discoveries occur we are well positioned to play an important role. An outstanding group of postdoctoral scholars, graduate students, staff scientists, and technical and administrative personnel support our efforts in experimental and theoretical physics. The PI’s on this grant are involved in the following program of experimental and theoretical activities:more » I) EXPERIMENTAL PHYSICS Our CMS group, led by Harvey Newman and Maria Spiropulu, has played a key role in the discovery and interpretation of the Higgs boson and in searches for new physics. They have important hardware responsibilities in both ECAL and HCAL and are also involved in the upgrades needed for the High Luminosity LHC. Newman's group also develops and operates Grid-based computing, networking, and collaborative systems for CMS and the US HEP community. The charged lepton (Mu2e) and quark BaBar flavor physics group is led by David Hitlin and Frank Porter. On Mu2e they have been instrumental in the design of the calorimeter. Construction responsibilities include one third of the crystals and associated readout as well as the calibration system. They also will have responsibility for a major part of the online system software. Although data taking ceased in 2008 the Caltech BaBar group is active on several new forefront analyses. The neutrino group is led by Ryan Patterson. They are central to NOvA's core oscillation physics program, to calibration, and to detector readiness being responsible for the production and installation of 12,000 APD arrays. They have key roles in neutrino appearance and disappearance analysis in MINOS and MINOS+. Sunil Golwala leads the dark matter direct detection effort. Areas of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these studies is the desire to gain a deeper understanding of superstring theory and M-theory. The research interests of Mark Wise span particle physics, cosmology and nuclear physics. His recent work has centered on extensions of the standard model where baryon number and lepton number are gauged and extensions of the standard model that have novel sources of baryon number violation and new sources of charged lepton flavor violation« less

Emerging therapies for Parkinson's disease.

PubMed

Poewe, Werner; Mahlknecht, Philipp; Jankovic, Joseph

2012-08-01

The experimental therapeutics of Parkinson's disease are reviewed, highlighting the current pipeline of emerging therapeutic approaches. This review includes novel approaches to dopaminergic drug delivery such as intraintestinal infusions or new extended-release formulations of levodopa and also intrapulmonary delivery of apomorphine as well as novel dopaminergic agents like the monoamine oxidase-B inhibitor safinamide or novel catechol-O-methyl transferase inhibitors. An even greater number of ongoing clinical trials assess the efficacy and safety of nondopaminergic approaches to enhance motor control or reduce motor complications like fluctuations and dyskinesias. These include adenosine A2A antagonists, α-adrenergic and serotonergic agonists as well as drugs acting on the glutamatergic system. Gene-based or cell-based intrastriatal delivery of therapeutic principles that enhance striatal dopaminergic transmission directly or via the stimulation of trophic activity has also reached phase II clinical development with encouraging results in some studies. Finally, a wide spectrum of agents with a potential for slowing disease progression is currently tested. A variety of medical and nonmedical interventions in different phases of clinical development provide an interesting and promising portfolio of emerging therapies for Parkinson's disease.

Microstructure design for fast oxygen conduction

DOE PAGES

Aidhy, Dilpuneet S.; Weber, William J.

2015-11-11

Research from the last decade has shown that in designing fast oxygen conducting materials for electrochemical applications has largely shifted to microstructural features, in contrast to material-bulk. In particular, understanding oxygen energetics in heterointerface materials is currently at the forefront, where interfacial tensile strain is being considered as the key parameter in lowering oxygen migration barriers. Nanocrystalline materials with high densities of grain boundaries have also gathered interest that could possibly allow leverage over excess volume at grain boundaries, providing fast oxygen diffusion channels similar to those previously observed in metals. In addition, near-interface phase transformations and misfit dislocations aremore » other microstructural phenomenon/features that are being explored to provide faster diffusion. In this review, the current understanding on oxygen energetics, i.e., thermodynamics and kinetics, originating from these microstructural features is discussed. Moreover, our experimental observations, theoretical predictions and novel atomistic mechanisms relevant to oxygen transport are highlighted. In addition, the interaction of dopants with oxygen vacancies in the presence of these new microstructural features, and their future role in the design of future fast-ion conductors, is outlined.« less

Phage phenomics: Physiological approaches to characterize novel viral proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanchez, Savannah E.; Cuevas, Daniel A.; Rostron, Jason E.

Current investigations into phage-host interactions are dependent on extrapolating knowledge from (meta)genomes. Interestingly, 60 - 95% of all phage sequences share no homology to current annotated proteins. As a result, a large proportion of phage genes are annotated as hypothetical. This reality heavily affects the annotation of both structural and auxiliary metabolic genes. Here we present phenomic methods designed to capture the physiological response(s) of a selected host during expression of one of these unknown phage genes. Multi-phenotype Assay Plates (MAPs) are used to monitor the diversity of host substrate utilization and subsequent biomass formation, while metabolomics provides bi-product analysismore » by monitoring metabolite abundance and diversity. Both tools are used simultaneously to provide a phenotypic profile associated with expression of a single putative phage open reading frame (ORF). Thus, representative results for both methods are compared, highlighting the phenotypic profile differences of a host carrying either putative structural or metabolic phage genes. In addition, the visualization techniques and high throughput computational pipelines that facilitated experimental analysis are presented.« less

Cell-flow technique.

PubMed

Hess, George P; Lewis, Ryan W; Chen, Yongli

2014-10-01

Various devices have been used to flow neurotransmitter solutions over cells containing receptors (e.g., ligand-gated ion channels) for whole-cell current recordings. With many of the devices, the orientation between the porthole of the flow device and the cell is not maintained absolutely constant. Orientation is critical for reproducibility in kinetic experiments. To be able to change the composition of the flowing solution during an experiment and still maintain a constant orientation, we use the cell-flow device described here. A peristaltic pump, a stainless steel U-tube, two different sizes of peristaltic tubing, and a solenoid valve are required to create a simple solution exchange system that can rapidly apply and remove solutions over the surface of a cell in tens of milliseconds. This system allows one to test multiple conditions on a cell containing the receptor of interest while constantly "washing" the cell with extracellular buffer solution between experimental applications. The use of the solenoid valve allows for the application of solutions to be precisely timed and controlled by a computer during electrophysiological current recording. © 2014 Cold Spring Harbor Laboratory Press.

GlobTherm, a global database on thermal tolerances for aquatic and terrestrial organisms.

PubMed

Bennett, Joanne M; Calosi, Piero; Clusella-Trullas, Susana; Martínez, Brezo; Sunday, Jennifer; Algar, Adam C; Araújo, Miguel B; Hawkins, Bradford A; Keith, Sally; Kühn, Ingolf; Rahbek, Carsten; Rodríguez, Laura; Singer, Alexander; Villalobos, Fabricio; Ángel Olalla-Tárraga, Miguel; Morales-Castilla, Ignacio

2018-03-13

How climate affects species distributions is a longstanding question receiving renewed interest owing to the need to predict the impacts of global warming on biodiversity. Is climate change forcing species to live near their critical thermal limits? Are these limits likely to change through natural selection? These and other important questions can be addressed with models relating geographical distributions of species with climate data, but inferences made with these models are highly contingent on non-climatic factors such as biotic interactions. Improved understanding of climate change effects on species will require extensive analysis of thermal physiological traits, but such data are both scarce and scattered. To overcome current limitations, we created the GlobTherm database. The database contains experimentally derived species' thermal tolerance data currently comprising over 2,000 species of terrestrial, freshwater, intertidal and marine multicellular algae, plants, fungi, and animals. The GlobTherm database will be maintained and curated by iDiv with the aim to keep expanding it, and enable further investigations on the effects of climate on the distribution of life on Earth.

Electrical conductivity changes during irreversible electroporation treatment of brain cancer.

PubMed

Garcia, Paulo A; Rossmeisl, John H; Davalos, Rafael V

2011-01-01

Irreversible electroporation (IRE) is a new minimally invasive technique to kill tumors and other undesirable tissue in a non-thermal manner. During an IRE treatment, a series of short and intense electric pulses are delivered to the region of interest to destabilize the cell membranes in the tissue and achieve spontaneous cell death. The alteration of the cellular membrane results in a dramatic increase in electrical conductivity during IRE as in other electroporation-based-therapies. In this study, we performed the planning and execution of an IRE brain cancer treatment using MRI reconstructions of the tumor and a multichannel array that served as a stereotactic fiducial and electrode guide. Using the tumor reconstructions within our numerical simulations, we developed equations relating the increase in tumor conductivity to calculated currents and volumes of tumor treated with IRE. We also correlated the experimental current measured during the procedure to an increase in tumor conductivity ranging between 3.42-3.67 times the baseline conductivity, confirming the physical phenomenon that has been detected in other tissues undergoing similar electroporation-based treatments.

Constraints on Europa's Ocean Composition Imposed by Its Surface Composition

NASA Astrophysics Data System (ADS)

Johnson, P. V.; Hodyss, R. P.; Vu, T. H.; Choukroun, M.

2017-12-01

Of the non-terrestrial environments within our Solar System, Europa's global liquid water ocean is arguably the most likely to be habitable. As such, understanding the habitability of Europa's ocean is of great interest to astrobiology and is the focus of missions currently being considered for further exploration of Europa. However, direct analysis of the ocean is unlikely in the foreseeable future. As such, our best means of constraining the subsurface ocean composition and its subsequent habitability currently is by further study of Europa's surface chemical composition. Recently, there has been a body of work published that looks at the chemistry of frozen brines representing putative ocean compositions. Here we take a simplified model of a four ionic component (Na, Mg, SO4, Cl) solution and map out what minerals are formed upon freezing as a function of relative ionic concentration, pH, etc. A `flow-chart' of the freezing sequence was developed based on both published and recently acquired experimental results. In performing this exercise, we are able to begin making meaningful links between observations of the surface chemistry and the chemical environment of the internal ocean.

High strain rate characterization of soft materials: past, present and possible futures

NASA Astrophysics Data System (ADS)

Siviour, Clive

2015-06-01

The high strain rate properties of low impedance materials have long been of interest to the community: the very first paper by Kolsky on his eponymous bars included data from man-made polymers and natural rubber. However, it has also long been recognized that characterizing soft or low impedance specimens under dynamic loading presents a number of challenges, mainly owing to the low sound speed in, and low stresses supported by, these materials. Over the past 20 years, significant progress has been made in high rate testing techniques, including better experimental design, more sensitive data acquisition and better understanding of specimen behavior. Further, a new generation of techniques, in which materials are characterized using travelling waves, rather than in a state of static equilibrium, promise to turn those properties that were previously a drawback into an advantage. This paper will give an overview of the history of high rate characterization, the current state of the art after an exciting couple of decades and some of the techniques currently being developed that have the potential to offer increased quality data in the future.

Phage phenomics: Physiological approaches to characterize novel viral proteins

DOE PAGES

Sanchez, Savannah E.; Cuevas, Daniel A.; Rostron, Jason E.; ...

2015-06-11

Current investigations into phage-host interactions are dependent on extrapolating knowledge from (meta)genomes. Interestingly, 60 - 95% of all phage sequences share no homology to current annotated proteins. As a result, a large proportion of phage genes are annotated as hypothetical. This reality heavily affects the annotation of both structural and auxiliary metabolic genes. Here we present phenomic methods designed to capture the physiological response(s) of a selected host during expression of one of these unknown phage genes. Multi-phenotype Assay Plates (MAPs) are used to monitor the diversity of host substrate utilization and subsequent biomass formation, while metabolomics provides bi-product analysismore » by monitoring metabolite abundance and diversity. Both tools are used simultaneously to provide a phenotypic profile associated with expression of a single putative phage open reading frame (ORF). Thus, representative results for both methods are compared, highlighting the phenotypic profile differences of a host carrying either putative structural or metabolic phage genes. In addition, the visualization techniques and high throughput computational pipelines that facilitated experimental analysis are presented.« less

Trying to detect gas-phase ions? Understanding Ion Mobility Spectrometry

PubMed Central

Cumeras, R.; Figueras, E.; Davis, C.E.; Baumbach, J.I.; Gràcia, I.

2014-01-01

Ion Mobility Spectrometry (IMS) is a widely used and ‘well-known’ technique of ion separation in gaseous phase based on the differences of ion mobilities under an electric field. This technique has received increased interest over the last several decades as evidenced by the pace and advances of new IMS devices available. In this review we explore the hyphenated techniques that are used with IMS, especially mass spectrometry as identification approach and multi-capillary column as pre-separation approach. Also, we will pay special attention to the key figures of merit of the ion mobility spectrum and how data is treated, and the influences of the experimental parameters in both a conventional drift time IMS (DTIMS) and a miniaturized IMS also known as high Field Asymmetric IMS (FAIMS) in the planar configuration. The current review article is preceded by a companion review article which details the current instrumentation and to the sections that configures both a conventional DTIMS and FAIMS devices. Those reviews will give the reader an insightful view of the main characteristics and aspects of the IMS technique. PMID:25465248

Simulation of the AC corona phenomenon with experimental validation

NASA Astrophysics Data System (ADS)

Villa, Andrea; Barbieri, Luca; Marco, Gondola; Malgesini, Roberto; Leon-Garzon, Andres R.

2017-11-01

The corona effect, and in particular the Trichel phenomenon, is an important aspect of plasma physics with many technical applications, such as pollution reduction, surface and medical treatments. This phenomenon is also associated with components used in the power industry where it is, in many cases, the source of electro-magnetic disturbance, noise and production of undesired chemically active species. Despite the power industry to date using mainly alternating current (AC) transmission, most of the studies related to the corona effect have been carried out with direct current (DC) sources. Therefore, there is technical interest in validating numerical codes capable of simulating the AC phenomenon. In this work we describe a set of partial differential equations that are comprehensive enough to reproduce the distinctive features of the corona in an AC regime. The model embeds some selectable chemical databases, comprising tens of chemical species and hundreds of reactions, the thermal dynamics of neutral species and photoionization. A large set of parameters—deduced from experiments and numerical estimations—are compared, to assess the effectiveness of the proposed approach.

Alcohol, red wine and cardiovascular disease.

PubMed

Wollin, S D; Jones, P J

2001-05-01

The objective of this article is to review the existing literature concerning the effects and mechanisms of action of red wine consumption vs. other alcoholic beverages on the risk of cardiovascular disease (CVD). Of particular interest is the form and quantity of alcohol consumed. This relationship between alcohol consumption and mortality is well supported by epidemiologic studies, which have suggested that different forms of alcohol alter the relative risk values for mortality from CVD. Although not without exception, current evidence from epidemiologic and experimental studies suggests a protective effect against the development of CVD with moderate consumption of red wine. The exact nature of the protective effect remains to be established. However, mechanisms including LDL oxidation and alterations in hemostatic variables are being increasingly recognized as contributory. Key components of red wine thought to be responsible for the protective effects include phenolic compounds and alcohol content. Despite the research presented, some questions relating to the current recommendations regarding moderate alcohol consumption and cardiovascular health remain. However, collectively, the literature aids in understanding some of the ways in which alcoholic beverages and their components affect the health of our population.

Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

PubMed Central

Kwon, Jee Young; Koedrith, Preeyaporn; Seo, Young Rok

2014-01-01

Engineered nanoparticles (NPs) are widely used in many sectors, such as food, medicine, military, and sport, but their unique characteristics may cause deleterious health effects. Close attention is being paid to metal NP genotoxicity; however, NP genotoxic/carcinogenic effects and the underlying mechanisms remain to be elucidated. In this review, we address some metal and metal oxide NPs of interest and current genotoxicity tests in vitro and in vivo. Metal NPs can cause DNA damage such as chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. We also discuss several parameters that may affect genotoxic response, including physicochemical properties, widely used assays/end point tests, and experimental conditions. Although potential biomarkers of nanogenotoxicity or carcinogenicity are suggested, inconsistent findings in the literature render results inconclusive due to a variety of factors. Advantages and limitations related to different methods for investigating genotoxicity are described, and future directions and recommendations for better understanding genotoxic potential are addressed. PMID:25565845

Performance analysis and simulation of vertical gallium nitride nanowire transistors

NASA Astrophysics Data System (ADS)

Witzigmann, Bernd; Yu, Feng; Frank, Kristian; Strempel, Klaas; Fatahilah, Muhammad Fahlesa; Schumacher, Hans Werner; Wasisto, Hutomo Suryo; Römer, Friedhard; Waag, Andreas

2018-06-01

Gallium nitride (GaN) nanowire transistors are analyzed using hydrodynamic simulation. Both p-body and n-body devices are compared in terms of threshold voltage, saturation behavior and transconductance. The calculations are calibrated using experimental data. The threshold voltage can be tuned from enhancement to depletion mode with wire doping. Surface states cause a shift of threshold voltage and saturation current. The saturation current depends on the gate design, with a composite gate acting as field plate in the p-body device. He joined Bell Laboratories, Murray Hill, NJ, as a Technical Staff Member. In October 2001, he joined the Optical Access and Transport Division, Agere Systems, Alhambra, CA. In 2004, he was appointed an Assistant Professor at ETH Zurich,. Since 2008, at the University of Kassel, Kassel, Germany, and he has been a Professor the Head of the Computational Electronics and Photonics Group, and co-director of CINSaT since 2010. His research interests include computational optoelectronics, process and device design of semiconductor photonic devices, microwave components, and electromagnetics modeling for nanophotonics. Dr. Witzigmann is a senior member of the SPIE and IEEE.

A nonlinear model for ionic polymer metal composites as actuators

NASA Astrophysics Data System (ADS)

Bonomo, C.; Fortuna, L.; Giannone, P.; Graziani, S.; Strazzeri, S.

2007-02-01

This paper introduces a comprehensive nonlinear dynamic model of motion actuators based on ionic polymer metal composites (IPMCs) working in air. Significant quantities ruling the acting properties of IPMC-based actuators are taken into account. The model is organized as follows. As a first step, the dependence of the IPMC absorbed current on the voltage applied across its thickness is taken into account; a nonlinear circuit model is proposed to describe this relationship. In a second step the transduction of the absorbed current into the IPMC mechanical reaction is modelled. The model resulting from the cascade of both the electrical and the electromechanical stages represents a novel contribution in the field of IPMCs, capable of describing the electromechanical behaviour of these materials and predicting relevant quantities in a large range of applied signals. The effect of actuator scaling is also investigated, giving interesting support to the activities involved in the design of actuating devices based on these novel materials. Evidence of the excellent agreement between the estimations obtained by using the proposed model and experimental signals is given.

Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease.

PubMed

Xicota, Laura; Rodriguez-Morato, Jose; Dierssen, Mara; de la Torre, Rafael

2017-01-01

Medical advances in the last decades have increased the average life expectancy, but also the incidence and prevalence of age-associated neurodegenerative diseases. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and the most prevalent type of dementia. A plethora of different mechanisms contribute to AD, among which oxidative stress plays a key role in its development and progression. So far, there are no pharmacological treatments available and the current medications are mainly symptomatic. In the last years, dietary polyphenols have gained research attention due to their interesting biological activities, and more specifically their antioxidant properties. (-)- Epigallocatechin-3-gallate (EGCG) is a natural flavanol that has been extensively studied regarding its potential effects in AD. In this review we present the current in vitro and in vivo experimentation regarding the use of EGCG in AD. We also review the complex mechanisms of action of EGCG, not only limited to its antioxidant activity, which may explain its beneficial health effects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Perceived Effects of Pornography on the Couple Relationship: Initial Findings of Open-Ended, Participant-Informed, "Bottom-Up" Research.

PubMed

Kohut, Taylor; Fisher, William A; Campbell, Lorne

2017-02-01

The current study adopted a participant-informed, "bottom-up," qualitative approach to identifying perceived effects of pornography on the couple relationship. A large sample (N = 430) of men and women in heterosexual relationships in which pornography was used by at least one partner was recruited through online (e.g., Facebook, Twitter, etc.) and offline (e.g., newspapers, radio, etc.) sources. Participants responded to open-ended questions regarding perceived consequences of pornography use for each couple member and for their relationship in the context of an online survey. In the current sample of respondents, "no negative effects" was the most commonly reported impact of pornography use. Among remaining responses, positive perceived effects of pornography use on couple members and their relationship (e.g., improved sexual communication, more sexual experimentation, enhanced sexual comfort) were reported frequently; negative perceived effects of pornography (e.g., unrealistic expectations, decreased sexual interest in partner, increased insecurity) were also reported, albeit with considerably less frequency. The results of this work suggest new research directions that require more systematic attention.

Partial spin absorption induced magnetization switching and its voltage-assisted improvement in an asymmetrical all spin logic device at the mesoscopic scale

NASA Astrophysics Data System (ADS)

Zhang, Yue; Zhang, Zhizhong; Wang, Lezhi; Nan, Jiang; Zheng, Zhenyi; Li, Xiang; Wong, Kin; Wang, Yu; Klein, Jacques-Olivier; Khalili Amiri, Pedram; Zhang, Youguang; Wang, Kang L.; Zhao, Weisheng

2017-07-01

Beyond memory and storage, future logic applications put forward higher requirements for electronic devices. All spin logic devices (ASLDs) have drawn exceptional interest as they utilize pure spin current instead of charge current, which could promise ultra-low power consumption. However, relatively low efficiencies of spin injection, transport, and detection actually impede high-speed magnetization switching and challenge perspectives of ASLD. In this work, we study partial spin absorption induced magnetization switching in asymmetrical ASLD at the mesoscopic scale, in which the injector and detector have the nano-fabrication compatible device size (>100 nm) and their contact areas are different. The enlarged contact area of the detector is conducive to the spin current absorption, and the contact resistance difference between the injector and the detector can decrease the spin current backflow. Rigorous spin circuit modeling and micromagnetic simulations have been carried out to analyze the electrical and magnetic features. The results show that, at the fabrication-oriented technology scale, the ferromagnetic layer can hardly be switched by geometrically partial spin current absorption. The voltage-controlled magnetic anisotropy (VCMA) effect has been applied on the detector to accelerate the magnetization switching by modulating magnetic anisotropy of the ferromagnetic layer. With a relatively high VCMA coefficient measured experimentally, a voltage of 1.68 V can assist the whole magnetization switching within 2.8 ns. This analysis and improving approach will be of significance for future low-power, high-speed logic applications.

Selfish mothers indeed! Resource-dependent conflict over extended parental care in free-ranging dogs

PubMed Central

2015-01-01

Parent–offspring conflict (POC) theory provides an interesting premise for understanding social dynamics in facultatively social species. In free-ranging dogs, mothers increase conflict over extended parental care with their pups beyond the weaning stage. In this study, we investigated whether resource quality affects POC in the dogs that typically live in a highly competitive environment as scavengers. We built a theoretical model to predict the alternative options available to the mother in the context of food sharing with her pups when protein-rich food (meat) is provided, as compared to carbohydrate-rich food (biscuits). We fit the mothers’ response from experimental data to the model and show that the mothers choose a selfish strategy, which can in turn ensure higher lifetime reproductive success, while depriving the current litter access to better resources. These results have interesting implications for understanding the social dynamics of the dogs, and the emergence of facultative sociality in a species that evolved from strongly social ancestors. We speculate that the tendency of increased conflict in resource-rich conditions might have driven the process of domestication in the ancestors of dogs which defected from their groups in favour of richer resources around human settlements. PMID:27019741

Working group report on beam plasmas, electronic propulsion, and active experiments using beams

NASA Technical Reports Server (NTRS)

Dawson, J. M.; Eastman, T.; Gabriel, S.; Hawkins, J.; Matossian, J.; Raitt, J.; Reeves, G.; Sasaki, S.; Szuszczewicz, E.; Winkler, J. R.

1986-01-01

The JPL Workshop addressed a number of plasma issues that bear on advanced spaceborne technology for the years 2000 and beyond. Primary interest was on the permanently manned space station with a focus on identifying environmentally related issues requiring early clarification by spaceborne plasma experimentation. The Beams Working Group focused on environmentally related threats that platform operations could have on the conduct and integrity of spaceborne beam experiments and vice versa. Considerations were to include particle beams and plumes. For purposes of definition it was agreed that the term particle beams described a directed flow of charged or neutral particles allowing single-particle trajectories to represent the characteristics of the beam and its propagation. On the other hand, the word plume was adopted to describe a multidimensional flow (or expansion) of a plasma or neutral gas cloud. Within the framework of these definitions, experiment categories included: (1) Neutral- and charged-particle beam propagation, with considerations extending to high powers and currents. (2) Evolution and dynamics of naturally occurring and man-made plasma and neutral gas clouds. In both categories, scientific interest focused on interactions with the ambient geoplasma and the evolution of particle densities, energy distribution functions, waves, and fields.

The application of molecular topology for ulcerative colitis drug discovery.

PubMed

Bellera, Carolina L; Di Ianni, Mauricio E; Talevi, Alan

2018-01-01

Although the therapeutic arsenal against ulcerative colitis has greatly expanded (including the revolutionary advent of biologics), there remain patients who are refractory to current medications while the safety of the available therapeutics could also be improved. Molecular topology provides a theoretic framework for the discovery of new therapeutic agents in a very efficient manner, and its applications in the field of ulcerative colitis have slowly begun to flourish. Areas covered: After discussing the basics of molecular topology, the authors review QSAR models focusing on validated targets for the treatment of ulcerative colitis, entirely or partially based on topological descriptors. Expert opinion: The application of molecular topology to ulcerative colitis drug discovery is still very limited, and many of the existing reports seem to be strictly theoretic, with no experimental validation or practical applications. Interestingly, mechanism-independent models based on phenotypic responses have recently been reported. Such models are in agreement with the recent interest raised by network pharmacology as a potential solution for complex disorders. These and other similar studies applying molecular topology suggest that some therapeutic categories may present a 'topological pattern' that goes beyond a specific mechanism of action.

Nondestructive inspection of aerospace composites by a fiber-coupled laser ultrasonics system

NASA Astrophysics Data System (ADS)

Vandenrijt, J.-F.; Languy, F.; Thizy, C.; Georges, M. P.

2017-06-01

Laser ultrasonics is a technique currently studied for nondestructive inspection of aerospace composite structures based on carbon fibers. It combines a pulsed laser impacting the surface generates an ultrasound inside the material, through the nondestructive thermoelastic effect. Second a detection interferometer probes the impacted point in order to measure the displacement of the surface resulting from the emitted ultrasound wave and the echo coming back from the different interfaces of the structure. Laser ultrasonics is of interest for inspecting complex shaped composites. We have studied the possibility of using frequency doubled YAG laser for the generation and which is fiber-coupled, together with a fibercoupled interferometric probe using a YAG laser in the NIR. Our final system is a lightweight probe attached to a robot arm and which is able to scan complex shapes. The performances of the system are compared for different wavelengths of generations. Also we have studied some experimental parameters of interest such as tolerance to angle and focus distance, and different geometries of generation beams. We show some examples of inspection of reference parts with known defects. In particular C-scans of curved composites structures are presented.

Homogeneous Molecular Catalysis of Electrochemical Reactions: Catalyst Benchmarking and Optimization Strategies.

PubMed

Costentin, Cyrille; Savéant, Jean-Michel

2017-06-21

Modern energy challenges currently trigger an intense interest in catalysis of redox reactions-electrochemical and photochemical-particularly those involving small molecules such as water, hydrogen, oxygen, proton, carbon dioxide. A continuously increasing number of molecular catalysts of these reactions, mostly transition metal complexes, have been proposed, rendering necessary procedures for their rational benchmarking and fueling the quest for leading principles that could inspire the design of improved catalysts. The search of "volcano plots" correlating catalysis kinetics to the stability of the key intermediate is a popular approach to the question in catalysis by surface-active sites, with as foremost example the electrochemical reduction of aqueous proton on metal surfaces. We discussed here for the first time, on theoretical and experimental grounds, the pertinence of such an approach in the field of molecular catalysis. This is the occasion to insist on the virtue of careful mechanism assignments. Particular emphasis is put on the interest of expressing the catalysts' intrinsic kinetic properties by means of catalytic Tafel plots, which relate kinetics and overpotential. We also underscore that the principle and strategies put forward for the catalytic activation of the above-mentioned small molecules are general as illustrated by catalytic applications out of this particular field.

[Melatonin and epilepsy].

PubMed

Rufo-Campos, M

2002-09-01

This review has been prepared in response to the increasing interest shown in understanding the part played by melatonin in the body, which has led to the search for new uses of it in cerebral disorders, such as sleep disorders including insomnia, irritability, depression, behaviour disorders and even the treatment of autism, since sleep disorders also occur in this condition. We pay particular attention to studies involving epilepsy. We show that interest in melatonin is rapidly increasing and new discoveries are being made of the part it plays in the biological regulation of circadian rhythm, sleep, mood, ageing, tumour growth and reproduction. Perhaps these processes between them have led to its use in the treatment of many current problems such as neuroprotection, migraine and the control of epileptic seizures. It has been shown that in both children and adults melatonin is of low toxicity and may be used in high risk persons. In this paper we make a careful analysis of recent publications in the medical literature dealing with the use of melatonin in the control of epileptic seizures and discuss its advantages and disadvantages. However, as with other types of treatment, further study, both experimental and otherwise, is necessary for confirmation.

Investigational drugs for the treatment of cervical cancer.

PubMed

Barra, Fabio; Lorusso, Domenica; Leone Roberti Maggiore, Umberto; Ditto, Antonino; Bogani, Giorgio; Raspagliesi, Francesco; Ferrero, Simone

2017-04-01

Cervical cancer (CC) is currently the fourth most common malignant disease of women worldwide. Although the incidence and the mortality rates have been decreasing with screening detection and new treatment strategies, a significant number of metastatic or recurrent disease is still diagnosed. For those patients not amenable to curative treatments, such as surgery and radiation, palliative chemotherapy remains the standard of care. As chemotherapy regimens have limited activity, research is focalized on investigating novel pharmacologic strategies. Areas covered: This paper aims to give a complete and updated overview on investigated therapies for the treatment of CC. The authors review the results of clinical studies and highlight the ongoing trials. Expert opinion: Agents targeting various molecular pathways including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR), poly ADP-ribose polymerase (PARP), epigenetics and other biological mechanisms represent interesting investigational opportunities. Amongst such drugs, bevacizumab, an anti-VEGF monoclonal antibody, was the first targeted drug recently approved by the FDA for the treatment of patients with metastatic, recurrent, or persistent CC. Another interesting experimental approach is represented by immunotherapy, which is leading to promising results with to the development of therapeutic vaccines and immune checkpoints inhibitors.

Gait biometrics under spoofing attacks: an experimental investigation

NASA Astrophysics Data System (ADS)

Hadid, Abdenour; Ghahramani, Mohammad; Kellokumpu, Vili; Feng, Xiaoyi; Bustard, John; Nixon, Mark

2015-11-01

Gait is a relatively biometric modality which has a precious advantage over other modalities, such as iris and voice, in that it can be easily captured from a distance. Although it has recently become a topic of great interest in biometric research, there has been little investigation into gait spoofing attacks where a person tries to imitate the clothing or walking style of someone else. We recently analyzed for the first time the effects of spoofing attacks on silhouette-based gait biometric systems and showed that it was indeed possible to spoof gait biometric systems by clothing impersonation and the deliberate selection of a target that has a similar build to the attacker. To gain deeper insight into the performance of current gait biometric systems under spoofing attacks, we provide a thorough investigation on how clothing can be used to spoof a target and evaluate the performance of two state-of-the-art recognition methods on a gait spoofing database recorded at the University of Southampton. Furthermore, we describe and evaluate an initial solution coping with gait spoofing attacks. The obtained results are very promising and point out interesting findings which can be used for future investigations.

Principles over principals? How innovation affects the agency relationship in medical and legal practice.

PubMed

Polaris, Julian J Z

2014-01-01

This Note outlines a conceptual framework for defining and analyzing innovation in the professional practice of medicine and law. The two professions have structural and historical similarities, and both are organized around the principal-agent relationship. Some types of professional activity adhere to the traditional agency model of principal-centered practice, but innovative professionals who develop novel tools and techniques often deviate from the agency model in interesting ways. This Note explores how that distinction plays out by identifying examples from academic medicine, public interest "cause lawyering", and corporate law. The field of medicine is governed by a regulatory regime that strictly differentiates routine practice from the experimental activities of clinical research, but the legal profession is governed by a monolithic code of conduct that does not explicitly acknowledge the types of innovation described here. Certain key events in the twentieth century help to explain why the government has chosen to tightly regulate innovation in medicine but not in law, and it turns out that innovators in both fields have found ways to stretch or bend the rules. These observations shed light on each profession's unique culture and can inform current debates over regulatory reform.

Experimental evolution and the dynamics of genomic mutation rate modifiers.

PubMed

Raynes, Y; Sniegowski, P D

2014-11-01

Because genes that affect mutation rates are themselves subject to mutation, mutation rates can be influenced by natural selection and other evolutionary forces. The population genetics of mutation rate modifier alleles has been a subject of theoretical interest for many decades. Here, we review experimental contributions to our understanding of mutation rate modifier dynamics. Numerous evolution experiments have shown that mutator alleles (modifiers that elevate the genomic mutation rate) can readily rise to high frequencies via genetic hitchhiking in non-recombining microbial populations. Whereas these results certainly provide an explanatory framework for observations of sporadically high mutation rates in pathogenic microbes and in cancer lineages, it is nonetheless true that most natural populations have very low mutation rates. This raises the interesting question of how mutator hitchhiking is suppressed or its phenotypic effect reversed in natural populations. Very little experimental work has addressed this question; with this in mind, we identify some promising areas for future experimental investigation.

Development of a Self-Balancing Human Transportation Vehicle for the Teaching of Feedback Control

ERIC Educational Resources Information Center

Lin, Shui-Chun; Tsai, Ching-Chih

2009-01-01

Control systems education often needs to design interesting hands-on exercises that keep students interested in the control theory presented in lectures. These exercises include system modeling, system analyses, controller syntheses, implementation, experimentation, and performance evaluation of a control system. This paper presents an interesting…

77 FR 2267 - Notice of Intent To Extend a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

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12 CFR 792.20 - What are the charges for each fee category?

Code of Federal Regulations, 2010 CFR

2010-01-01

... a use or purpose that furthers the commercial, trade, or profit interests of the requester or the... higher education, an institution of professional education, and an institution of vocational education... news means information that is about current events or that would be of current interest to the public...

Computational and Experimental Approaches to Visual Aesthetics

PubMed Central

Brachmann, Anselm; Redies, Christoph

2017-01-01

Aesthetics has been the subject of long-standing debates by philosophers and psychologists alike. In psychology, it is generally agreed that aesthetic experience results from an interaction between perception, cognition, and emotion. By experimental means, this triad has been studied in the field of experimental aesthetics, which aims to gain a better understanding of how aesthetic experience relates to fundamental principles of human visual perception and brain processes. Recently, researchers in computer vision have also gained interest in the topic, giving rise to the field of computational aesthetics. With computing hardware and methodology developing at a high pace, the modeling of perceptually relevant aspect of aesthetic stimuli has a huge potential. In this review, we present an overview of recent developments in computational aesthetics and how they relate to experimental studies. In the first part, we cover topics such as the prediction of ratings, style and artist identification as well as computational methods in art history, such as the detection of influences among artists or forgeries. We also describe currently used computational algorithms, such as classifiers and deep neural networks. In the second part, we summarize results from the field of experimental aesthetics and cover several isolated image properties that are believed to have a effect on the aesthetic appeal of visual stimuli. Their relation to each other and to findings from computational aesthetics are discussed. Moreover, we compare the strategies in the two fields of research and suggest that both fields would greatly profit from a joined research effort. We hope to encourage researchers from both disciplines to work more closely together in order to understand visual aesthetics from an integrated point of view. PMID:29184491

Medical experiments on persons with special needs, a comparative study of Islamic jurisprudence vs. Arab laws: UAE law as case study.

PubMed

Hammad, Hamza Abed Al-Karim

2014-01-01

This article is a comparative study of medical experiments on persons with special needs in Islamic jurisprudence and Arab laws; United Arab Emirates (UAE) law as case study. The current study adopts a comparative analytical and descriptive approach. The conclusion of this study points out that the Convention on the Rights of Persons with Special Needs, ratified by a number of Arab States, including the United Arab Emirates, approves conducting medical experiments on persons with special needs, subject to their free consent. As a result of ratifying this Convention, a number of special laws were enacted to be enforced in the United Arab Emirates. On the other hand, this issue is controversial from an Islamic jurisprudence point of view. One group of jurisprudents permits conducting these experimentations if they are designed to treat the person involved, and prohibits such experimentations for scientific advancement. Other jurisprudents permit conducting medical experimentations on persons with special needs, whether the purpose of such experimentations is treatment of the disabled or achieving scientific advancement. The opinion of this group is consistent with the International Convention and the Arab laws in this respect. However, neither the Convention nor the Arab laws regulate this matter by specific and comprehensive conditions, as addressed by some contemporary scholars. It is recommended that the Convention and the Arab laws adopt these conditions. Additionally, the Convention does not state whether the experimentations may be conducted for the interest of the person with disability or for the purpose of scientific advancement. The text of the Convention is unclear and therefore requires further illumination.

Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision.

PubMed

Gil-Pagés, Macarena; Stiles, Robert J; Parks, Christopher A; Neier, Steven C; Radulovic, Maja; Oliveros, Alfredo; Ferrer, Alejandro; Reed, Brendan K; Wilton, Katelynn M; Schrum, Adam G

2013-08-23

There is significant interest in the generation of improved assays to clearly identify experimental mice possessing functional vision, a property that could qualify mice for inclusion in behavioral and neuroscience studies. Widely employed current methods rely on mouse responses to visual cues in assays of reflexes, depth perception, or cognitive memory. However, commonly assessed mouse reflexes can sometimes be ambiguous in their expression, while depth perception assays are sometimes confounded by variation in anxiety responses and exploratory conduct. Furthermore, in situations where experimental groups vary in their cognitive memory capacity, memory assays may not be ideal for assessing differences in vision. We have optimized a non-invasive behavioral assay that relies on an untrained, innate response to identify individual experimental mice possessing functional vision: slow angled-descent forepaw grasping (SLAG). First, we verified that SLAG performance depends on vision and not olfaction. Next, all members of an age-ranged cohort of 158 C57BL/6 mice (57 wild-type, 101 knockout, age range 44-241 days) were assessed for functional vision using the SLAG test without training or conditioning. Subjecting the population to a second innate behavioral test, Dark Chamber preference, corroborated that the functional vision assessment of SLAG was valid. We propose that the SLAG assay is immediately useful to quickly and clearly identify experimental mice possessing functional vision. SLAG is based on a behavioral readout with a significant innate component with no requirement for training. This will facilitate the selection of mice of known sighted status in vision-dependent experiments that focus on other types of behavior, neuroscience, and/or cognitive memory.

The impact of feedback valence and communication style on intrinsic motivation in middle childhood: Experimental evidence and generalization across individual differences.

PubMed

Mabbe, Elien; Soenens, Bart; De Muynck, Gert-Jan; Vansteenkiste, Maarten

2018-06-01

Prior research among adolescents and emerging adults has provided evidence for the beneficial effects of positive (relative to negative) feedback and an autonomy-supportive (relative to a controlling) communication style on students' intrinsic motivation. Unfortunately, similar experimental research in middle childhood is lacking. Moreover, little attention has been paid to the question of whether individual differences in personality and perceived parenting play a role in these effects. In the current experimental study (N = 110; M age  = 10.71 years), children completed puzzles at school under one of four experimental conditions, thereby crossing normative feedback valence (i.e., positive vs. negative) with communication style (i.e., autonomy supportive vs. controlling). Prior to the experiment, children filled out questionnaires tapping into the Big Five personality traits and into perceived maternal autonomy support and psychological control. After the experimental induction, children rated several motivational constructs (i.e., intrinsic motivation and need-based experiences). In addition, their voluntary behavioral persistence in a subsequent challenging puzzle task was recorded objectively. Providing positive normative feedback in an autonomy-supportive way yielded the most favorable motivational outcomes. Both feedback valence and communication style yielded an independent impact on children's experiences of competence and autonomy during task engagement, which in turn helped to explain children's elevated intrinsic motivation, as reflected by their perceived interest and behavioral persistence. A few effects were moderated by children's perceived parenting and personality traits, but the number of interactions was limited. The discussion focuses on the motivating role of positive normative feedback and an autonomy-supportive communication style for children. Copyright © 2018 Elsevier Inc. All rights reserved.

Slow angled-descent forepaw grasping (SLAG): an innate behavioral task for identification of individual experimental mice possessing functional vision

PubMed Central

2013-01-01

Background There is significant interest in the generation of improved assays to clearly identify experimental mice possessing functional vision, a property that could qualify mice for inclusion in behavioral and neuroscience studies. Widely employed current methods rely on mouse responses to visual cues in assays of reflexes, depth perception, or cognitive memory. However, commonly assessed mouse reflexes can sometimes be ambiguous in their expression, while depth perception assays are sometimes confounded by variation in anxiety responses and exploratory conduct. Furthermore, in situations where experimental groups vary in their cognitive memory capacity, memory assays may not be ideal for assessing differences in vision. Results We have optimized a non-invasive behavioral assay that relies on an untrained, innate response to identify individual experimental mice possessing functional vision: slow angled-descent forepaw grasping (SLAG). First, we verified that SLAG performance depends on vision and not olfaction. Next, all members of an age-ranged cohort of 158 C57BL/6 mice (57 wild-type, 101 knockout, age range 44–241 days) were assessed for functional vision using the SLAG test without training or conditioning. Subjecting the population to a second innate behavioral test, Dark Chamber preference, corroborated that the functional vision assessment of SLAG was valid. Conclusions We propose that the SLAG assay is immediately useful to quickly and clearly identify experimental mice possessing functional vision. SLAG is based on a behavioral readout with a significant innate component with no requirement for training. This will facilitate the selection of mice of known sighted status in vision-dependent experiments that focus on other types of behavior, neuroscience, and/or cognitive memory. PMID:23971729

Computational and Experimental Approaches to Visual Aesthetics.

PubMed

Brachmann, Anselm; Redies, Christoph

2017-01-01

Aesthetics has been the subject of long-standing debates by philosophers and psychologists alike. In psychology, it is generally agreed that aesthetic experience results from an interaction between perception, cognition, and emotion. By experimental means, this triad has been studied in the field of experimental aesthetics , which aims to gain a better understanding of how aesthetic experience relates to fundamental principles of human visual perception and brain processes. Recently, researchers in computer vision have also gained interest in the topic, giving rise to the field of computational aesthetics . With computing hardware and methodology developing at a high pace, the modeling of perceptually relevant aspect of aesthetic stimuli has a huge potential. In this review, we present an overview of recent developments in computational aesthetics and how they relate to experimental studies. In the first part, we cover topics such as the prediction of ratings, style and artist identification as well as computational methods in art history, such as the detection of influences among artists or forgeries. We also describe currently used computational algorithms, such as classifiers and deep neural networks. In the second part, we summarize results from the field of experimental aesthetics and cover several isolated image properties that are believed to have a effect on the aesthetic appeal of visual stimuli. Their relation to each other and to findings from computational aesthetics are discussed. Moreover, we compare the strategies in the two fields of research and suggest that both fields would greatly profit from a joined research effort. We hope to encourage researchers from both disciplines to work more closely together in order to understand visual aesthetics from an integrated point of view.

A Novel Experimental Apparatus (PDL) and Its Application in Higher Education in Japan and Cambodia

NASA Astrophysics Data System (ADS)

Sou, K.; Kato, T.; Oto, K.; Sakurai, T.; Yamamoto, K.; Omosa, E.; Tozaki, K.

2010-07-01

Low cost and attractive equipment for use in experimental higher physics education has been desired by teachers, especially those in developing world. A system of novel experimental apparatus named Personal Desk Lab (PDL) was developed [1]. Each apparatus is miniaturized to one-fifth of the conventional one or less, and built on a steel plate; therefore, it is portable and can be used on a classroom desk. Each set is constructed by some parts divided according to their functions, and some of the parts are used in a number of experiments; which saves material, cost, and storage space. All parts are designed to be easy to make, maintain and repair. Almost all apparatus are battery driven [2]. After ICPE 2006, we have improved the system continuously; consequently, the experimental themes cover the field of mechanics, electromagnetism and optics. The number of these themes in use exceeds ten. The performance of PDL has been tested at Chiba University, Japan and Royal University of Phnom Penh (RUPP), Cambodia. In Chiba University, physics education with PDL is currently conducted individually to 80(max.) students in a classroom at the same time, and to more than 900 students per year. Experiment class using PDL in Cambodia started on October 2008 with 120 students of physics department, RUPP. They were divided into three classes, and conducted four experimental themes in pairs. The advantages confirmed from the practices at two universities are as follows: (1) the use of PDL arouses learner's interest, promotes their deep understanding extensively, and inspires to learn further; and (2) costs for introduction and running of PDL system are fairly small compared to the traditional one. Furthermore, the instruction for distant learners having PDL on each hand was conducted successfully through internet.

Atmosphere-Ionosphere Electrodynamic Coupling

NASA Astrophysics Data System (ADS)

Sorokin, V. M.; Chmyrev, V. M.

Numerous phenomena that occur in the mesosphere, ionosphere, and the magnetosphere of the Earth are caused by the sources located in the lower atmosphere and on the ground. We describe the effects produced by lightning activity and by ground-based transmitters operated in high frequency (HF) and very low frequency (VLF) ranges. Among these phenomena are the ionosphere heating and the formation of plasma density inhomogeneities, the excitation of gamma ray bursts and atmospheric emissions in different spectral bands, the generation of ULF/ELF/VLF electromagnetic waves and plasma turbulence in the ionosphere, the stimulation of radiation belt electron precipitations and the acceleration of ions in the upper ionosphere. The most interesting results of experimental and theoretical studies of these phenomena are discussed below. The ionosphere is subject to the action of the conductive electric current flowing in the atmosphere-ionosphere circuit. We present a physical model of DC electric field and current formation in this circuit. The key element of this model is an external current, which is formed with the occurrence of convective upward transport of charged aerosols and their gravitational sedimentation in the atmosphere. An increase in the level of atmospheric radioactivity results in the appearance of additional ionization and change of electrical conductivity. Variation of conductivity and external current in the lower atmosphere leads to perturbation of the electric current flowing in the global atmosphere-ionosphere circuit and to the associated DC electric field perturbation both on the Earth's surface and in the ionosphere. Description of these processes and some results of the electric field and current calculations are presented below. The seismic-induced electric field perturbations produce noticeable effects in the ionosphere by generating the electromagnetic field and plasma disturbances. We describe the generation mechanisms of such experimentally observed effects as excitation of plasma density inhomogeneities, field-aligned currents, and ULF/ELF emissions and the modification of electron and ion altitude profiles in the upper ionosphere. The electrodynamic model of the ionosphere modification under the influence of some natural and man-made processes in the atmosphere is also discussed. The model is based on the satellite and ground measurements of electromagnetic field and plasma perturbations and on the data on atmospheric radioactivity and soil gas injection into the atmosphere.

Graduate Students' Interest in Immunology as a Discipline

ERIC Educational Resources Information Center

Kwarteng, Alexander; Frimpong, Michael; Sylverken, Augustina Angelina; Arthur, Yarhands D.; Ahuno, Samuel T.; Owusu-Dabo, Ellis

2017-01-01

Interest and motivation significantly influence achievement; however, interest in immunology remains to be determined. Using a structured questionnaire, the current study assessed for the first time interest in immunology among biomedical graduate students in Ghana after a one-week introduction to immunology course. Our results revealed that…

Vocational Interests and Prospective College Majors among Youth of Color in Poverty

ERIC Educational Resources Information Center

Diemer, Matthew A.; Wang, Qiu; Smith, Aaron V.

2010-01-01

A clear sense of vocational interests may facilitate high school students' capacity to connect current interests to congruent educational and occupational environments. This is particularly important for youth who experience external constraints on career development and college attendance. This study examined how well vocational interests,…

17 CFR 256.237 - Interest accrued.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Interest accrued. 256.237... COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.237 Interest accrued. This account shall include the amount of interest accrued on all liabilities of the service company. Supporting records shall...

17 CFR 256.237 - Interest accrued.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Interest accrued. 256.237... COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.237 Interest accrued. This account shall include the amount of interest accrued on all liabilities of the service company. Supporting records shall...

Empirical Modeling of Physiochemical Immune Response of Multilayer Zinc Oxide Nanomaterials under UV Exposure to Melanoma and Foreskin Fibroblasts

NASA Astrophysics Data System (ADS)

Fakhar-E-Alam, Muhammad; Akram, M. Waseem; Iqbal, Seemab; Alimgeer, K. S.; Atif, M.; Sultana, K.; Willander, M.; Wang, Zhiming M.

2017-04-01

Carcinogenesis is a complex molecular process starting with genetic and epigenetic alterations, mutation stimulation, and DNA modification, which leads to proteomic adaptation ending with an uncontrolled proliferation mechanism. The current research focused on the empirical modelling of the physiological response of human melanoma cells (FM55P) and human foreskin fibroblasts cells (AG01518) to the multilayer zinc oxide (ZnO) nanomaterials under UV-A exposure. To validate this experimental scheme, multilayer ZnO nanomaterials were grown on a femtotip silver capillary and conjugated with protoporphyrin IX (PpIX). Furthermore, PpIX-conjugated ZnO nanomaterials grown on the probe were inserted into human melanoma (FM55P) and foreskin fibroblasts cells (AG01518) under UV-A light exposure. Interestingly, significant cell necrosis was observed because of a loss in mitochondrial membrane potential just after insertion of the femtotip tool. Intense reactive oxygen species (ROS) fluorescence was observed after exposure to the ZnO NWs conjugated with PpIX femtotip model under UV exposure. Results were verified by applying several experimental techniques, e.g., ROS detection, MTT assay, and fluorescence spectroscopy. The present work reports experimental modelling of cell necrosis in normal human skin as well as a cancerous tissue. These obtained results pave the way for a more rational strategy for biomedical and clinical applications.

Lorentz violation and gravity

NASA Astrophysics Data System (ADS)

Bailey, Quentin G.

2007-08-01

This work explores the theoretical and experimental aspects of Lorentz violation in gravity. A set of modified Einstein field equations is derived from the general Lorentz-violating Standard-Model Extension (SME). Some general theoretical implications of these results are discussed. The experimental consequences for weak-field gravitating systems are explored in the Earth- laboratory setting, the solar system, and beyond. The role of spontaneous Lorentz-symmetry breaking is discussed in the context of the pure-gravity sector of the SME. To establish the low-energy effective Einstein field equations, it is necessary to take into account the dynamics of 20 coefficients for Lorentz violation. As an example, the results are compared with bumblebee models, which are general theories of vector fields with spontaneous Lorentz violation. The field equations are evaluated in the post- newtonian limit using a perfect fluid description of matter. The post-newtonian metric of the SME is derived and compared with some standard test models of gravity. The possible signals for Lorentz violation due to gravity-sector coefficients are studied. Several new effects are identified that have experimental implications for current and future tests. Among the unconventional effects are a new type of spin precession for a gyroscope in orbit and a modification to the local gravitational acceleration on the Earth's surface. These and other tests are expected to yield interesting sensitivities to dimensionless gravity- sector coefficients.

Prediction and Computation of Corrosion Rates of A36 Mild Steel in Oilfield Seawater

NASA Astrophysics Data System (ADS)

Paul, Subir; Mondal, Rajdeep

2018-04-01

The parameters which primarily control the corrosion rate and life of steel structures are several and they vary across the different ocean and seawater as well as along the depth. While the effect of single parameter on corrosion behavior is known, the conjoint effects of multiple parameters and the interrelationship among the variables are complex. Millions sets of experiments are required to understand the mechanism of corrosion failure. Statistical modeling such as ANN is one solution that can reduce the number of experimentation. ANN model was developed using 170 sets of experimental data of A35 mild steel in simulated seawater, varying the corrosion influencing parameters SO4 2-, Cl-, HCO3 -,CO3 2-, CO2, O2, pH and temperature as input and the corrosion current as output. About 60% of experimental data were used to train the model, 20% for testing and 20% for validation. The model was developed by programming in Matlab. 80% of the validated data could predict the corrosion rate correctly. Corrosion rates predicted by the ANN model are displayed in 3D graphics which show many interesting phenomenon of the conjoint effects of multiple variables that might throw new ideas of mitigation of corrosion by simply modifying the chemistry of the constituents. The model could predict the corrosion rates of some real systems.

Methods for processing high-throughput RNA sequencing data.

PubMed

Ares, Manuel

2014-11-03

High-throughput sequencing (HTS) methods for analyzing RNA populations (RNA-Seq) are gaining rapid application to many experimental situations. The steps in an RNA-Seq experiment require thought and planning, especially because the expense in time and materials is currently higher and the protocols are far less routine than those used for other high-throughput methods, such as microarrays. As always, good experimental design will make analysis and interpretation easier. Having a clear biological question, an idea about the best way to do the experiment, and an understanding of the number of replicates needed will make the entire process more satisfying. Whether the goal is capturing transcriptome complexity from a tissue or identifying small fragments of RNA cross-linked to a protein of interest, conversion of the RNA to cDNA followed by direct sequencing using the latest methods is a developing practice, with new technical modifications and applications appearing every day. Even more rapid are the development and improvement of methods for analysis of the very large amounts of data that arrive at the end of an RNA-Seq experiment, making considerations regarding reproducibility, validation, visualization, and interpretation increasingly important. This introduction is designed to review and emphasize a pathway of analysis from experimental design through data presentation that is likely to be successful, with the recognition that better methods are right around the corner. © 2014 Cold Spring Harbor Laboratory Press.