Ideas and Problems Contained in the Astronomical Manuscripts Kept in Bosnia and Herzegovina

NASA Astrophysics Data System (ADS)

Hadzibegovic, Zalkida

2007-04-01

This paper is a summary of dissertation research regarding the ideas and problems contained in the astronomical manuscripts written in the Arabic alphabet and in Oriental languages, which are kept in Bosnia and Herzegovina. The main aim of this paper is to show the role and development of the astronomical ideas contained in the manuscripts and the methods explaining the highlighted problems. According to the analyzed manuscripts, ideas in Bosnian science were mainly influenced by Arabic-Islamic countries, while European influence was less important. Even in the time of Copernican heliocentric ideas, the old Arabic astronomy was still current in Bosnia and Herzegovina, primarily for satisfying religious needs of Muslims, such as prayer timekeeping and sacred direction location, by scientific methods.

Battery condenser system total particulate emission factors and rates for cotton gins

USDA-ARS?s Scientific Manuscript database

This manuscript is part of a series of manuscripts that characterize cotton gin emissions from the standpoint of stack sampling. The impetus behind this project was the urgent need to collect additional cotton gin emissions data to address current regulatory issues. A key component of this study was...

Battery condenser system PM10 emission factors and rates for cotton gins

USDA-ARS?s Scientific Manuscript database

This manuscript is part of a series of manuscripts that to characterize cotton gin emissions from the standpoint of stack sampling. The impetus behind this project was the urgent need to collect additional cotton gin emissions data to address current regulatory issues. A key component of this study ...

Battery condenser system total particulate emission factors and rates for cotton gins: Method 17

USDA-ARS?s Scientific Manuscript database

This manuscript is part of a series of manuscripts that characterize cotton gin emissions from the standpoint of stack sampling. The impetus behind this project was the urgent need to collect additional cotton gin emissions data to address current regulatory issues. A key component of this study was...

Technical Standards and Medieval Manuscripts.

ERIC Educational Resources Information Center

Hollas, Eric

Even though medieval manuscripts represent the most voluminous surviving artifact from the Middle Ages, the very nature of this resource presents challenges for usage. In an effort to preserve medieval manuscripts and to create broader and more economical access to their contents, many libraries have in recent decades sought to provide filmed…

Publication Rate and Impact Factor for Society of Military Orthopedic Surgeons. Annual Meeting Presentations, 2009-2013.

PubMed

Orr, Justin; Dunn, John C; Kusnezov, Nicholas; Fares, Austin B; Waterman, Brian R; Garcia, E'stephan; Pallis, Mark

2017-11-01

The Society of Military Orthopaedic Surgeons (SOMOS) is a robust academic organization with more than 1,000 members and has held annual academic scientific meetings since 1958. Currently, there is a paucity of data regarding the volume and quality of orthopaedic surgery presentations accepted for peer-reviewed publication. The purpose of this study was to answer the following questions: (1) What is the publication acceptance rate for abstract presented at SOMOS meetings? (2) What is the distribution by orthopaedic subspecialty for SOMOS presentations accepted for publication? (3) What is the overall quality of these publications? Abstracts of podium presentations at SOMOS were reviewed from 2009 to 2013. Author institutional information was obtained. Abstracts were then queried in PubMed to obtain publication status, time to publication, and impact factor of the journal in which the manuscript was successfully published. From 2009 to 2013, 592 abstracts were presented at the SOMOS conference. Overall, 59% of abstracts went on to publication at a mean of 18.1 months. Published manuscripts appeared in 59 journals with a mean impact factor of 2.6. The subspecialties of spine (67%) and basic science (66%) achieved the highest abstract publication rate while sports had the highest mean impact factor (3.3). The annual SOMOS meeting is a productive academic event, producing quality presentations resulting in a high manuscript publication rate in every orthopaedic surgery subspecialty. This is the first series to demonstrate overall productivity of a general orthopaedic surgery scientific meeting as well as the subspecialty-specific impact factors of published investigations. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.

Exploring Reviewer Reactions to Manuscripts Submitted to Academic Journals

ERIC Educational Resources Information Center

Coniam, David

2012-01-01

This paper extends a previous study (Coniam, 2011) into a corpus of manuscript (MS) reviews conducted for the journal System by one reviewer in the eight-year period 2003-2011. The current paper highlights additional facets of the review process that focus on issues involving authors themselves. The study examines two related sets of research…

Battery condenser system PM10 emission factors and rates for cotton gins: Method 201A PM10 sizing cyclones

USDA-ARS?s Scientific Manuscript database

This manuscript is part of a series of manuscripts that to characterize cotton gin emissions from the standpoint of stack sampling. The impetus behind this project was the urgent need to collect additional cotton gin emissions data to address current regulatory issues. A key component of this study ...

Examples of challenges and opportunities in visual analysis in the digital humanities

NASA Astrophysics Data System (ADS)

Rushmeier, Holly; Pintus, Ruggero; Yang, Ying; Wong, Christiana; Li, David

2015-03-01

The massive digitization of books and manuscripts has converted millions of works that were once only physical into electronic documents. This conversion has made it possible for scholars to study large bodies of work, rather than just individual texts. This has offered new opportunities for scholarship in the humanities. Much previous work on digital collections has relied on optical character recognition and focused on the textual content of books. New work is emerging that is analyzing the visual layout and content of books and manuscripts. We present two different digital humanities projects in progress that present new opportunities for extracting data about the past, with new challenges for designing systems for scholars to interact with this data. The first project we consider is the layout and spectral content of thousands of pages from medieval manuscripts. We present the techniques used to study content variations in sets of similar manuscripts, and to study material variations that may indicate the location of manuscript production. The second project is the analysis of representations in the complete archive of Vogue magazine over 120 years. We present samples of applying computer vision techniques to understanding the changes in representation of women over time.

Greek Manuscripts at the Wellcome Library in London: A Descriptive Catalogue

PubMed Central

Bouras-Vallianatos, Petros

2015-01-01

This article presents a new, detailed catalogue of the Greek manuscripts at the Wellcome Library in London. It consists of an introduction to the history of the collection and its scholarly importance, followed by separate entries for each manuscript. Each entry identifies the text(s) found in the respective manuscript – including reference to existing printed edition(s) of such texts – and gives a physical description of the codex, details on its provenance and bibliographical references. PMID:25766544

Is knowledge translation without patient or community engagement flawed?

PubMed

Ramsden, Vivian R; Rabbitskin, Norma; Westfall, John M; Felzien, Maret; Braden, Janice; Sand, Jessica

2017-06-01

The engagement of patients/individuals and/or communities has become increasingly important in all aspects of the research process. The aim of this manuscript is to begin the discussion about the use and implementation of authentic engagement in the development of presentations and manuscripts which evolve from research that has engaged patients/individuals and/or communities. Community-Based Participatory Research; Transformative Action Research. In Canada, the framework for engaging patients/individuals and/or communities is clearly outlined in Chapter 9 of the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans which indicates that when research projects involving First Nations, Inuit and Métis peoples, the peoples in these communities are to have a role in shaping/co-creating the research that affects them. It is increasingly important that presentations and manuscripts that evolve from results/findings which have engaged patients/individuals and/or communities be co-presented/co-published. Presentations are often done without patients/individuals and/or communities and manuscripts published with only academic authors. Frequently, grants submitted and subsequently funded do not consider this aspect of the process in the budget which makes integrated and outcome knowledge translation, dissemination and distribution by and with patients/individuals and/or communities difficult to facilitate. This manuscript was designed to begin the discussion at various levels related to authentic engagement in the development of presentations and manuscripts which evolve from research that has engaged patients/individuals and/or communities. How will you include patients/individuals and/or communities in your presentations and publications? © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Inaugural editorial.

PubMed

Maisto, Stephen A

2009-03-01

Gives a brief history of the Psychology of Addictive Behaviors, noting its current premier status among addictions journals. The editor discusses the types of manuscripts that the journal publishes, covering a wide range of topics and substantive areas. The plan is to keep the journal as an outlet for publication of manuscripts concerning all of the addictive behaviors. (PsycINFO Database Record (c) 2009 APA, all rights reserved).

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.

PubMed

Lal, Devyani; Jategaonkar, Ameya A; Borish, Larry; Chambliss, Linda R; Gnagi, Sharon H; Hwang, Peter H; Rank, Matthew A; Stankiewicz, James A; Lund, Valerie J

2016-06-01

Management of rhinosinusitis during pregnancy requires special considerations. 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations. The systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea. Eighty-eight manuscripts underwent full review after screening 3052 abstracts. No relevant level 1, 2, or 3 studies were found. Expert panel recommendations for rhinosinusitis management during pregnancy included continuing nasal corticosteroid sprays for CRS maintenance, using pregnancy-safe antibiotics for acute rhinosinusitis and CRS exacerbations, and discontinuing aspirin desensitization for aspirin exacerbated respiratory disease. The manuscript presents detailed recommendations. The lack of evidence pertinent to managing rhinosinusitis during pregnancy warrants future trials. Expert recommendations constitute the current best available evidence.

How should bladder sensation be measured? ICI-RS 2011.

PubMed

De Wachter, S; Smith, Philip P; Smith, P; Tannenbaum, C; Van Koeveringe, G; Drake, M; Wyndaele, J J; Chapple, C

2012-03-01

Disturbed bladder sensations, or in broader terms, sensory dysfunctions are increasingly recognized as key elements in the origin and manifestation of symptom syndromes of urinary dysfunction. Adequate assessment of bladder sensation is crucial to improve our understanding of the pathophysiology and treatment of urinary dysfunction. This manuscript summarizes the discussions of a think tank on "How to measure bladder sensation" held at the ICI-RS meeting in 2011. Based upon literature reviews on bladder sensation presented at the think tank in the ICI-RS meeting, discussions evolved which were summarized in the ICI-RS report. Different physicians/researchers further elaborated on this report, which is presented in this manuscript. Bladder sensations are not merely the result of bladder distension. Other factors inside the bladder or bladder wall: central processing and/or cognitive manipulation may play an important role. Current methods to measure sensations such as urodynamics, voiding diaries, forced diuresis, electrical stimulation and brain imaging are likely sub-optimal as they only consider part of these factors in isolation. Different methods to measure bladder sensations have been described and are used in clinical practice. Current methods only address part of the parameters responsible for the generation and perception of urinary sensations. Further focused research is required, and several recommendations are provided. Copyright © 2012 Wiley Periodicals, Inc.

Novel features of the nonlinear model arising in nano-ionic currents throughout microtubules

NASA Astrophysics Data System (ADS)

Celik, E.; Bulut, H.; Baskonus, H. M.

2018-05-01

In this manuscript, the modified exp (- Ω (ξ )) -expansion function method is implemented to find the new solutions to the nonlinear differential equation being the transmission line model. We obtain some new solutions to this model such as complex, exponential, trigonometric and hyperbolic functions. We plot the two- and three-dimensional surfaces of each solutions obtained in this manuscript.

Rare Book and Manuscript Libraries in the Twenty-First Century.

ERIC Educational Resources Information Center

Wendorf, Richard, Ed.

Revised versions of the talks presented at the symposium are presented here. A preliminary discussion paper opens the manuscript, exploring the implications of changing patterns in teaching, research, and scholarship, the new demands of the marketplace and libraries' resultant collection development, the changing technologies, future staffing,…

Keywords and Co-Occurrence Patterns in the Voynich Manuscript: An Information-Theoretic Analysis

PubMed Central

Montemurro, Marcelo A.; Zanette, Damián H.

2013-01-01

The Voynich manuscript has remained so far as a mystery for linguists and cryptologists. While the text written on medieval parchment -using an unknown script system- shows basic statistical patterns that bear resemblance to those from real languages, there are features that suggested to some researches that the manuscript was a forgery intended as a hoax. Here we analyse the long-range structure of the manuscript using methods from information theory. We show that the Voynich manuscript presents a complex organization in the distribution of words that is compatible with those found in real language sequences. We are also able to extract some of the most significant semantic word-networks in the text. These results together with some previously known statistical features of the Voynich manuscript, give support to the presence of a genuine message inside the book. PMID:23805215

Authorship Concerns and Who Truly Owns a Research Idea?

PubMed Central

Tran, Duc Q.; Kemper, Alex R.; Geme, Joseph W. St.; Lantos, John D.

2015-01-01

Researchers often face dilemmas about authorship. When the researchers are graduate students, fellows, or junior faculty, the dilemmas might involve discussions about fair criteria for more senior faculty to be acknowledged as key contributors or authors on manuscripts. This “Ethics Rounds” presents a case in which a fellow faced such a dilemma. We review current journal guidelines for authorship and some ethical considerations that should help make this process more streamlined. PMID:26459651

Special Issue of Solid-State Electronics, dedicated to EUROSOI-ULIS 2016

NASA Astrophysics Data System (ADS)

Sverdlov, Viktor; Selberherr, Siegfried

2017-02-01

The current special issue of Solid-State Electronics includes 29 extended papers presented at the 2016 Second Joint International EUROSOI Workshop and International Conference on Ultimate Integration on Silicon (EUROSOI-ULIS 2016) held in Wien, Austria, on January 25-27, 2016. The papers entering to the special issue have been selected by the EUROSOI-ULIS 2016 Technical Program Committee based on the excellence of abstracts submitted and presentations delivered at the conference. In order to comply with the high standards of Solid-State Electronics the manuscripts went through the standard reviewing procedure.

Waste not, want not

PubMed Central

Rockman, Howard A.

2014-01-01

As of the writing of this Editorial, the current JCI Editorial Board has evaluated approximately 7,000 manuscripts over the past 22 months for their suitability for publication in our journal. While many of you have received a negative decision on your manuscript, I suspect few are aware of the changes we have made to our review process to limit reviewers’ requests for what is in our view unnecessary and excessive experimentation. PMID:24487638

Measures of the home environment related to childhood obesity: a systematic review.

PubMed

Pinard, Courtney A; Yaroch, Amy L; Hart, Michael H; Serrano, Elena L; McFerren, Mary M; Estabrooks, Paul A

2012-01-01

Due to a proliferation of measures for different components of the home environment related to childhood obesity, the purpose of the present systematic review was to examine these tools and the degree to which they can validly and reliably assess the home environment. Relevant manuscripts published between 1998 and 2010 were obtained through electronic database searches and manual searches of reference lists. Manuscripts were included if the researchers reported on a measure of the home environment related to child eating and physical activity (PA) and childhood obesity and reported on at least one psychometric property. Of the forty papers reviewed, 48 % discussed some aspect of parenting specific to food. Fifty-per cent of the manuscripts measured food availability/accessibility, 18 % measured PA availability/accessibility, 20 % measured media availability/accessibility, 30 % focused on feeding style, 23 % focused on parenting related to PA and 20 % focused on parenting related to screen time. Many researchers chose to design new measures for their studies but often the items employed were brief and there was a lack of transparency in the psychometric properties. Many of the current measures of the home food and PA environment focus on one or two constructs; more comprehensive measures as well as short screeners guided by theoretical models are necessary to capture influences in the home on food and PA behaviours of children. Finally, the current measures of the home environment do not necessarily translate to specific sub-populations. Recommendations were made for future validation of measures in terms of appropriate psychometric testing.

Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids.

PubMed

Deckelbaum, Richard J; Leaf, Alexander; Mozaffarian, Dariush; Jacobson, Terry A; Harris, William S; Akabas, Sharon R

2008-06-01

After the symposium "Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids," faculty who presented at the conference submitted manuscripts relating to their conference topics, and these are presented in this supplement. The content of these manuscripts was reviewed, and 2 conference calls were convened. The objective was to summarize existing evidence, gaps in evidence, and future research needed to strengthen recommendations for specific intakes of n-3 fatty acids for different conditions relating to cardiovascular disease. The following 2 questions were the main items discussed. What are the roles of n-3 fatty acids in primary versus secondary prevention of coronary heart disease? What are the roles of n-3 fatty acids in hypertriglyceridemia, in the metabolic syndrome and type 2 diabetes, and in sudden cardiac death, cardiac arrhythmias, and vulnerable plaque? Each area was summarized by using 2 general categories: 1) current knowledge for which general consensus exists, and 2) recommendations for research and policy. Additional references for these conclusions can be found in the articles included in the supplement.

From Hahnemann's hand to your computer screen: building a digital homeopathy collection

PubMed Central

Mix, Lisa A; Cameron, Kathleen

2011-01-01

The University of California, San Francisco (UCSF), Library holds the unique manuscript of the sixth edition of Samuel Hahnemann's Organon der Heilkunst, the primary text of homeopathy. The manuscript volume is Hahnemann's own copy of the fifth edition of the Organon with his notes for the sixth edition, handwritten throughout the volume. There is a high level of interest in the Organon manuscript, particularly among homeopaths. This led to the decision to present a digital surrogate on the web to make it accessible to a wider audience. Digitizing Hahnemann's manuscript and determining the best method of presentation on the web posed several challenges. Lessons learned in the course of this project will inform future digital projects. This article discusses the historical significance of the sixth edition of Hahnemann's Organon, its context in UCSF's homeopathy collections, and the specifics of developing the online homeopathy collection. PMID:21243055

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations

PubMed Central

Lal, Devyani; Jategaonkar, Ameya A.; Borish, Larry; Chambliss, Linda R.; Gnagi, Sharon H.; Hwang, Peter H.; Rank, Matthew A.; Stankiewicz, James A.; Lund, Valerie J.

2018-01-01

Background Management of rhinosinusitis during pregnancy requires special considerations. Objectives 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations. Methods The systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea. Results Eighty-eight manuscripts underwent full review after screening 3052 abstracts. No relevant level 1, 2, or 3 studies were found. Expert panel recommendations for rhinosinusitis management during pregnancy included continuing nasal corticosteroid sprays for CRS maintenance, using pregnancy-safe antibiotics for acute rhinosinusitis and CRS exacerbations, and discontinuing aspirin desensitization for aspirin exacerbated respiratory disease. The manuscript presents detailed recommendations. Conclusions The lack of evidence pertinent to managing rhinosinusitis during pregnancy warrants future trials. Expert recommendations constitute the current best available evidence. PMID:26800862

Genetic Variation Underlying Traumatic Brain injury (TBI) and Late Onset Alzheimer’s Disease (LOAD)

DTIC Science & Technology

2017-10-01

Episodic memory trajectories (EMTs), longitudinal evaluations , Alzheimer’s Disease, Traumatic Brain Injury (TBI), dementia 3. ACCOMPLISHMENTS  What were... evaluate potential manuscripts/conference presentations etc SA3. To investigate whether rare coding variants in the loci...available WES datasets for replication Task 5. Report results and evaluate potential manuscripts/conference presentations

Urological research in sub-Saharan Africa: a retrospective cohort study of abstracts presented at the Nigerian Association of Urological Surgeons conferences.

PubMed

Bello, Jibril Oyekunle

2013-11-14

Nigeria is one of the top three countries in Africa in terms of science research output and Nigerian urologists' biomedical research output contributes to this. Each year, urologists in Nigeria gather to present their recent research at the conference of the Nigerian Association of Urological Surgeons (NAUS). These abstracts are not thoroughly vetted as are full length manuscripts published in peer reviewed journals but the information they disseminate may affect clinical practice of attendees. This study aims to describe the characteristics of abstracts presented at the annual conferences of NAUS, the quality of the abstracts as determined by the subsequent publication of full length manuscripts in peer-review indexed journals and the factors that influence such successful publication. Abstracts presented at the 2007 to 2010 NAUS conferences were identified through conference abstracts books. Using a strict search protocol, publication in peer-reviewed journals was determined. The abstracts characteristics were analyzed and their quality judged by subsequent successful publishing of full length manuscripts. Statistical analysis was performed using SPSS 16.0 software to determine factors predictive of successful publication. Only 75 abstracts were presented at the NAUS 2007 to 2010 conferences; a quarter (24%) of the presented abstracts was subsequently published as full length manuscripts. Median time to publication was 15 months (range 2-40 months). Manuscripts whose result data were analyzed with 'beyond basic' statistics of frequencies and averages were more likely to be published than those with basic or no statistics. Quality of the abstracts and thus subsequent publication success is influenced by the use of 'beyond basic' statistics in analysis of the result data presented. There is a need for improvement in the quality of urological research from Nigeria.

Canadian pharmacy practice residents' projects: publication rates and study characteristics.

PubMed

Hung, Michelle; Duffett, Mark

2013-03-01

Research projects are a key component of pharmacy residents' education. Projects represent both a large investment of effort for each resident (up to 10 weeks over the residency year) and a large body of research (given that there are currently over 150 residency positions in Canada annually). Publication of results is a vital part of the dissemination of information gleaned from these projects. To determine the publication rate for research projects performed under the auspices of accredited English-language hospital pharmacy residency programs in Canada and to describe the study characteristics of residency projects performed in Ontario from 1999/2000 to 2008/2009. Lists of residents and project titles for the period of interest were obtained from residency coordinators. PubMed, CINAHL, the Canadian Journal of Hospital Pharmacy, and Google were searched for evidence of publication of each project identified, as an abstract or presentation at a meeting, a letter to the editor, or a full-text manuscript. The library holdings of the University of Toronto were reviewed to determine study characteristics of the Ontario residency projects. For the objective of this study relating to publication rate, 518 projects were included. The overall publication rate was 32.2% (60 [35.9%] as abstracts and 107 [64.1%] as full-text manuscripts). Publication in pharmacy-specific journals (66 [61.7%] of 107 full-text manuscripts) was more frequent than publication in non-pharmacy-specific journals. The publication rate of projects as full-text manuscripts remained stable over time. Of the 202 Ontario residency projects archived in the University of Toronto's library, most were cohort studies (83 [41.1%]), and the most common topic was efficacy and/or safety of a medication (46 [22.8%]). Most hospital pharmacy residents' projects were unpublished, and the publication rate of projects as full-text manuscripts has not increased over time. Most projects were observational studies. Increasing publication rates and creating a central database or repository of residency projects would increase the dissemination and accessibility of residents' research.

How to write a discussion section?

PubMed Central

Şanlı, Öner; Erdem, Selçuk; Tefik, Tzevat

2013-01-01

Writing manuscripts to describe study outcomes, although not easy, is the main task of an academician. The aim of the present review is to outline the main aspects of writing the discussion section of a manuscript. Additionally, we address various issues regarding manuscripts in general. It is advisable to work on a manuscript regularly to avoid losing familiarity with the article. On principle, simple, clear and effective language should be used throughout the text. In addition, a pre-peer review process is recommended to obtain feedback on the manuscript. The discussion section can be written in 3 parts: an introductory paragraph, intermediate paragraphs and a conclusion paragraph. For intermediate paragraphs, a “divide and conquer” approach, meaning a full paragraph describing each of the study endpoints, can be used. In conclusion, academic writing is similar to other skills, and practice makes perfect. PMID:26328131

Multiscale Pigment Analysis of Medieval Illuminated Manuscripts

NASA Astrophysics Data System (ADS)

Sestak, Erica; Manukyan, Khachatur; Wiescher, Michael; Gura, David

2017-09-01

Three medieval illuminated manuscripts (codd. Lat. b. 1; Lat. b. 2; Lat. e. 4), housed at the University of Notre Dame's Hesburgh Library, vary in style, pigments, scribes, and regions, despite all three being Psalters used in the Late Middle Ages. XRF and Raman spectroscopy, which provided the elemental and molecular composition of the pigments, respectively, were used to analyze the pigments' compositions in an attempt to narrow further the manuscripts' possible origins. This experimental investigation emphasizes the importance of understanding the history of the manuscript through their pigments. Codd. Lat. b. 1 and Lat. b. 2 are Latinate German Psalters from the fifteenth century likely used in Katharinenkloster in Nuremberg. While there are visible differences in style within each Psalter, the variations in some of the pigment compositions, such as the inconstant presence of zinc, suggest different admixtures. Cod. Lat. e. 4 is a Latinate English Psalter from the fourteenth century, and it was written by two scribes and illuminated by two distinct painters. It is currently being tested to determine whether there are any correlations between the scribes and painters. These physical analyses will clarify the origins and provenances of the manuscripts.

Featured Article: Genotation: Actionable knowledge for the scientific reader

PubMed Central

Willis, Ethan; Sakauye, Mark; Jose, Rony; Chen, Hao; Davis, Robert L

2016-01-01

We present an article viewer application that allows a scientific reader to easily discover and share knowledge by linking genomics-related concepts to knowledge of disparate biomedical databases. High-throughput data streams generated by technical advancements have contributed to scientific knowledge discovery at an unprecedented rate. Biomedical Informaticists have created a diverse set of databases to store and retrieve the discovered knowledge. The diversity and abundance of such resources present biomedical researchers a challenge with knowledge discovery. These challenges highlight a need for a better informatics solution. We use a text mining algorithm, Genomine, to identify gene symbols from the text of a journal article. The identified symbols are supplemented with information from the GenoDB knowledgebase. Self-updating GenoDB contains information from NCBI Gene, Clinvar, Medgen, dbSNP, KEGG, PharmGKB, Uniprot, and Hugo Gene databases. The journal viewer is a web application accessible via a web browser. The features described herein are accessible on www.genotation.org. The Genomine algorithm identifies gene symbols with an accuracy shown by .65 F-Score. GenoDB currently contains information regarding 59,905 gene symbols, 5633 drug–gene relationships, 5981 gene–disease relationships, and 713 pathways. This application provides scientific readers with actionable knowledge related to concepts of a manuscript. The reader will be able to save and share supplements to be visualized in a graphical manner. This provides convenient access to details of complex biological phenomena, enabling biomedical researchers to generate novel hypothesis to further our knowledge in human health. This manuscript presents a novel application that integrates genomic, proteomic, and pharmacogenomic information to supplement content of a biomedical manuscript and enable readers to automatically discover actionable knowledge. PMID:26900164

Featured Article: Genotation: Actionable knowledge for the scientific reader.

PubMed

Nagahawatte, Panduka; Willis, Ethan; Sakauye, Mark; Jose, Rony; Chen, Hao; Davis, Robert L

2016-06-01

We present an article viewer application that allows a scientific reader to easily discover and share knowledge by linking genomics-related concepts to knowledge of disparate biomedical databases. High-throughput data streams generated by technical advancements have contributed to scientific knowledge discovery at an unprecedented rate. Biomedical Informaticists have created a diverse set of databases to store and retrieve the discovered knowledge. The diversity and abundance of such resources present biomedical researchers a challenge with knowledge discovery. These challenges highlight a need for a better informatics solution. We use a text mining algorithm, Genomine, to identify gene symbols from the text of a journal article. The identified symbols are supplemented with information from the GenoDB knowledgebase. Self-updating GenoDB contains information from NCBI Gene, Clinvar, Medgen, dbSNP, KEGG, PharmGKB, Uniprot, and Hugo Gene databases. The journal viewer is a web application accessible via a web browser. The features described herein are accessible on www.genotation.org The Genomine algorithm identifies gene symbols with an accuracy shown by .65 F-Score. GenoDB currently contains information regarding 59,905 gene symbols, 5633 drug-gene relationships, 5981 gene-disease relationships, and 713 pathways. This application provides scientific readers with actionable knowledge related to concepts of a manuscript. The reader will be able to save and share supplements to be visualized in a graphical manner. This provides convenient access to details of complex biological phenomena, enabling biomedical researchers to generate novel hypothesis to further our knowledge in human health. This manuscript presents a novel application that integrates genomic, proteomic, and pharmacogenomic information to supplement content of a biomedical manuscript and enable readers to automatically discover actionable knowledge. © 2016 by the Society for Experimental Biology and Medicine.

Malaysian Journal of Medical Sciences’ Performance Status in 2016

PubMed Central

Zulkapli, Nour Azimah; Abdullah, Jafri Malin

2017-01-01

This editorial aims to report on the performance of the Malaysian Journal of Medical Sciences (MJMS) in the year 2016. The performance report is based on an analysis of the auto-generated data compiled from the ScholarOne Manuscripts™. It will specifically focus on the pattern of manuscript submission, geographical distribution of contributors, manuscript submission by month and the acceptance-rejection rate of post-review manuscripts. It will also discuss the effects of the decision to raise the article acceptance standards. The MJMS would also like to share the news of its receipt of the 2016 Current Research in Malaysia (CREAM) award. This honour was bestowed upon us by the Ministry of Higher Education (MOHE) of Malaysia, on November 1, 2016. PMID:29379381

Proceedings of the Workshop on Microtechnologies and Applications to Space Systems

NASA Technical Reports Server (NTRS)

Wilson, B. A. (Editor)

1993-01-01

This volume serves as the Proceedings of this workshop. It contains the manuscripts provided by plenary and parallel session presenters, and summary reports generated from this material and from information presented during the panel discussions. Where manuscripts were not provided, extended abstracts, if available, have been included. The order of the papers follows the original workshop agenda.

How to Write Your First Research Paper

PubMed Central

Kallestinova, Elena D.

2011-01-01

Writing a research manuscript is an intimidating process for many novice writers in the sciences. One of the stumbling blocks is the beginning of the process and creating the first draft. This paper presents guidelines on how to initiate the writing process and draft each section of a research manuscript. The paper discusses seven rules that allow the writer to prepare a well-structured and comprehensive manuscript for a publication submission. In addition, the author lists different strategies for successful revision. Each of those strategies represents a step in the revision process and should help the writer improve the quality of the manuscript. The paper could be considered a brief manual for publication. PMID:21966034

How to write your first research paper.

PubMed

Kallestinova, Elena D

2011-09-01

Writing a research manuscript is an intimidating process for many novice writers in the sciences. One of the stumbling blocks is the beginning of the process and creating the first draft. This paper presents guidelines on how to initiate the writing process and draft each section of a research manuscript. The paper discusses seven rules that allow the writer to prepare a well-structured and comprehensive manuscript for a publication submission. In addition, the author lists different strategies for successful revision. Each of those strategies represents a step in the revision process and should help the writer improve the quality of the manuscript. The paper could be considered a brief manual for publication. Copyright © 2011.

Pigment identification on medieval manuscripts, paintings and other artefacts by Raman microscopy: applications to the study of three German manuscripts

NASA Astrophysics Data System (ADS)

Burgio, Lucia; Ciomartan, Dan A.; Clark, Robin J. H.

1997-03-01

The identification of the pigments used to illuminate medieval manuscripts, paintings and other artefacts has received a major boost recently through perceptive studies carried out by Raman microscopy. A brief summary of the background of the technique is given. The results of studies on three illuminated German manuscripts are presented. The pigments vermilion HgS, iron oxide Fe 2O 3, azurite 2CuCO 3.Cu(OH) 2, malachite CuCo 3.Cu(OH) 2, lampblack (essentially carbon), white lead 2PbCO 3.Pb(OH) 2, lead tin yellow type I Pb 2SnO 4, and lazurite Na 8[Al 6Si 6O 24]S n (but only in admixture with Pb 2SnO 4, whereby it forms a green pigment), have been identified on these manuscripts on the basis of Raman microscopy and the results discussed.

ISDRS 2016 special issue foreword

NASA Astrophysics Data System (ADS)

Iliadis, Agis A.; Akturk, Akin; Tompkins, Randy P.

2017-10-01

This 8th ISDRS Special Issue of Solid-State Electronics contains manuscripts presented at the 2016 International Semiconductor Device Research Symposium (ISDRS 2016) that was held at the Hyatt Regency Hotel, in Bethesda, Maryland, on December 7-9, 2016. A total of 32 manuscripts were submitted, which were sent out for review by both the ISDRS Guest Editors, Agis Iliadis, Akin Akturk, Randy Tompkins, and the Solid-State Electronics Editor, Alex Zaslavsky. This ISDRS Special Issue of Solid-State Electronics contains the manuscripts selected through this rigorous review process.

What happens to medical articles submitted in Spanish that are not accepted for publication?

PubMed

Matías-Guiu, J A; García-Ramos, R; Castellanos, M; Martínez-Vila, E; Matías-Guiu, J

2013-05-01

The fate of manuscripts submitted and subsequently rejected by Spanish-language journals is unknown. The present study was designed to determine whether or not articles submitted to Neurología are published following rejection, and if so, where. We searched Medline in late April 2012 and also analysed all manuscripts rejected by Neurología between October 2004 and April 2012 according to that journal's two databases. In that period, 1277 articles were submitted to the journal. Of the 271 manuscripts rejected by Neurología, 54 articles (19.9%) were published in other journals. Neurology journals published 31 of the manuscripts (57.4%); 43 manuscripts (79.6%) appeared in Spanish-language journals. Of the rejected manuscripts, 24.1% of the originals, 8.3% of the letters to the editor, 28.9% of the case reports, 22.6% of the reviews and 6.3% of the images were published. Authors with three previously published articles on the same topic managed to publish their manuscripts in 34% of the cases, compared to only 11.8% of authors with fewer published articles (P < .0001). Of the total manuscripts rejected between 2004 and 2010, 24.8% were eventually published. The median time lapse between article submission and publication was 13 months (range, 2-59 months). Manuscripts rejected by Neurología are often published in other journals, but this scenario is not as common as in English-language journals. In the case of Neurología, the editor's decision to reject an article is more significant than it would be in an English-language journal because the author will have fewer additional possibilities of having the manuscript published. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Transoral robotic thyroid surgery

PubMed Central

Clark, James H.; Kim, Hoon Yub

2015-01-01

There is currently significant demand for minimally invasive thyroid surgery; however the majority of proposed surgical approaches necessitate a compromise between minimal tissue dissection with a visible cervical scar or extensive tissue dissection with a remote, hidden scar. The development of transoral endoscopic thyroid surgery however provides an approach which is truly minimally invasive, as it conceals the incision within the oral cavity without significantly increasing the amount of required dissection. The transoral endoscopic approach however presents multiple technical challenges, which could be overcome with the incorporation of a robotic operating system. This manuscript summarizes the literature on the feasibility and current clinical experience with transoral robotic thyroid surgery. PMID:26425456

The postgenomic era: implications for the clinical laboratory.

PubMed

Kiechle, Frederick L; Zhang, Xinbo

2002-03-01

To review the advances in clinically useful molecular biological techniques and to identify their applications in clinical practice, as presented at the Tenth Annual William Beaumont Hospital DNA Symposium. The 11 manuscripts submitted were reviewed and their major findings were compared with literature on the same topic. Manuscripts address creative thinking techniques applied to DNA discovery, extraction of DNA from clotted blood, the relationship of mitochondrial dysfunction in neurodegenerative disorders, and molecular methods to identify human lymphocyte antigen class I and class II loci. Two other manuscripts review current issues in molecular microbiology, including detection of hepatitis C virus and biological warfare. The last 5 manuscripts describe current issues in molecular cardiovascular disease, including assessing thrombotic risk, genomic analysis, gene therapy, and a device for aiding in cardiac angiogenesis. Novel problem-solving techniques have been used in the past and will be required in the future in DNA discovery. The extraction of DNA from clotted blood demonstrates a potential cost-effective strategy. Cybrids created from mitochondrial DNA-depleted cells and mitochondrial DNA from a platelet donor have been useful in defining the role mitochondria play in neurodegeneration. Mitochondrial depletion has been reported as a genetically inherited disorder or after human immunodeficiency virus therapy. Hepatitis C viral detection by qualitative, quantitative, or genotyping techniques is useful clinically. Preparedness for potential biological warfare is a responsibility of all clinical laboratorians. Thrombotic risk in cardiovascular disorders may be assessed by coagulation screening assays and further defined by mutation analysis for specific genes for prothrombin and factor V Leiden. Gene therapy for reducing arteriosclerotic risk has been hindered primarily by complications introduced by the vectors used to introduce the therapeutic genes. Neovascularization in cardiac muscle with occluded vessels represents a promising method for recovery of viable tissue following ischemia. The sequence of the human genome was reported by 2 groups in February 2001. The postgenomic era will emphasize the use of microarrays and database software for genomic and proteomic screening in the search for useful clinical assays. The number of molecular pathologic techniques and assays will expand as additional disease-associated mutations are defined. Gene therapy and tissue engineering will represent successful therapeutic adjuncts.

Energy anisotropy as a function of the direction of spin magnetization for a doublet system

NASA Astrophysics Data System (ADS)

Cherry, Peter J.; Malkin, Vladimir G.; Malkina, Olga L.; Asher, James R.

2016-11-01

This manuscript describes new phenomena that currently are not taken into account in both experimental EPR spectra interpretations and quantum chemical calculations of EPR parameters. This article presents an argument, with evidence, against the common belief that in the absence of an external magnetic field the total energy of a doublet system is independent of the spin orientation. Consequences of this phenomenon for interpretation of EPR experimental studies as well as for quantum chemical calculations of EPR parameters are discussed.

Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science.

PubMed

Huang, Kun; Liu, Yunlong; Huang, Yufei; Li, Lang; Cooper, Lee; Ruan, Jianhua; Zhao, Zhongming

2016-08-22

We summarize the 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) and the editorial report of the supplement to BMC Genomics. The supplement includes 20 research articles selected from the manuscripts submitted to ICIBM 2015. The conference was held on November 13-15, 2015 at Indianapolis, Indiana, USA. It included eight scientific sessions, three tutorials, four keynote presentations, three highlight talks, and a poster session that covered current research in bioinformatics, systems biology, computational biology, biotechnologies, and computational medicine.

Authorship Concerns and Who Truly Owns a Research Idea?

PubMed

Syed, Sana; Tran, Duc Q; Kemper, Alex R; Geme, Joseph W St; Lantos, John D

2015-11-01

Researchers often face dilemmas about authorship. When the researchers are graduate students, fellows, or junior faculty, the dilemmas might involve discussions about fair criteria for more senior faculty to be acknowledged as key contributors or authors on manuscripts. This "Ethics Rounds" presents a case in which a fellow faced such a dilemma. We review current journal guidelines for authorship and some ethical considerations that should help make this process more streamlined. Copyright © 2015 by the American Academy of Pediatrics.

Imaging in diabetic retinopathy.

PubMed

Salz, David A; Witkin, Andre J

2015-01-01

While the primary method for evaluating diabetic retinopathy involves direct and indirect ophthalmoscopy, various imaging modalities are of significant utility in the screening, evaluation, diagnosis, and treatment of different presentations and manifestations of this disease. This manuscript is a review of the important imaging modalities that are used in diabetic retinopathy, including color fundus photography, fluorescein angiography, B-scan ultrasonography, and optical coherence tomography. The article will provide an overview of these different imaging techniques and how they can be most effectively used in current practice.

Image Segmentation of Historical Handwriting from Palm Leaf Manuscripts

NASA Astrophysics Data System (ADS)

Surinta, Olarik; Chamchong, Rapeeporn

Palm leaf manuscripts were one of the earliest forms of written media and were used in Southeast Asia to store early written knowledge about subjects such as medicine, Buddhist doctrine and astrology. Therefore, historical handwritten palm leaf manuscripts are important for people who like to learn about historical documents, because we can learn more experience from them. This paper presents an image segmentation of historical handwriting from palm leaf manuscripts. The process is composed of three steps: 1) background elimination to separate text and background by Otsu's algorithm 2) line segmentation and 3) character segmentation by histogram of image. The end result is the character's image. The results from this research may be applied to optical character recognition (OCR) in the future.

Scientific writing seminar for early-stage investigators in substance abuse research.

PubMed

Guydish, Joseph; Masson, Carmen; Flentje, Annesa; Shopshire, Michael; Sorensen, James L

2016-01-01

There is little information on how to increase the scientific writing productivity of early-stage investigators in the addictions field. A scientific writing seminar is presented in this article, aiming to encourage manuscript writing and dissemination of addiction research, and outcomes are reported for 14 years of the seminar. In 14 years, there were 113 postdoctoral fellow enrollments in a 6-month writing seminar. Records of submission and publication rates of manuscripts were collected for 14 cohorts. Of the 113 participant enrollments, 97 (86%) submitted a manuscript for publication, and 87 participants (77%) published their manuscript. A scientific writing seminar may benefit writing productivity, but more research is needed to compare this training model with other existing models.

Scientific Writing Seminar for Early-stage Investigators in Substance Abuse Research

PubMed Central

Guydish, Joseph; Masson, Carmen; Flentje, Annesa; Shopshire, Michael; Sorensen, James L.

2015-01-01

Background There is little information on how to increase the scientific writing productivity of early-stage investigators in the addictions field. A scientific writing seminar is presented in this article, aiming to encourage manuscript writing and dissemination of addiction research, and outcomes are reported for 14 years of the seminar. Methods In 14 years there were 113 postdoctoral fellow enrollments in a 6-month writing seminar. Records of submission and publication rates of manuscripts were collected for 14 cohorts. Results Of the 113 participant enrollments, 97 (86%) submitted a manuscript for publication, and 87 participants (77%) published their manuscript. Conclusions A scientific writing seminar may benefit writing productivity, but more research is needed to compare this training model to other existing models. PMID:25893689

More than a Footnote to History in Cultural-Historical Theory: The Zalkind Summary, Experimental Study of Higher Behavioural Processes, and "Vygotsky's Blocks"

ERIC Educational Resources Information Center

Towsey, Paula M.

2009-01-01

This article presents what is possibly the first English translation of a 1930 manuscript related to Vygotsky's work (probably written by Vygotsky himself). This manuscript, the Zalkind Summary, is a five-point summary of his presentation to the First All-Union Congress on the Study of Human Behaviour in Leningrad in January 1930. This article…

Qualitative Research and Community-Based Participatory Research: Considerations for Effective Dissemination in the Peer-Reviewed Literature.

PubMed

Grieb, Suzanne Dolwick; Eder, Milton Mickey; Smith, Katherine C; Calhoun, Karen; Tandon, Darius

2015-01-01

Qualitative research is appearing with increasing frequency in the public health and medical literature. Qualitative research in combination with a community-based participatory research (CBPR) approach can be powerful. However little guidance is available on how to present qualitative research within a CBPR framework for peer-review publications. This article provides a brief overview of how qualitative research can advance CBPR partnerships and outlines practical guidelines for writing for publication about qualitative research within a CBPR framework to (1) guide partners with little experience publishing in peer-reviewed journals and/or (2) facilitate effective preparation of manuscripts grounded in qualitative research for peer-reviewed journals. We provide information regarding the specific benefits of qualitative inquiry in CBPR, tips for organizing the manuscript, questions to consider in preparing the manuscript, common mistakes in the presentation of qualitative research, and examples of peer-reviewed manuscripts presenting qualitative research conducted within a CBPR framework. Qualitative research approaches have tremendous potential to integrate community and researcher perspectives to inform community health research findings. Effective dissemination of CBPR informed qualitative research findings is crucial to advancing health disparities research.

[Astrologic and medical manuscript of the 18th Century].

PubMed

Kugener, Henri

2010-01-01

We present a manuscript from the 18th century, an extract taken from the "Great and the Little Albert" attributed to Albertus Magnus. The linguistic variety in the paper is typical for a text composed in Luxembourg. Added to this text are two incantations and a short cartomancy paper.

VOLATILE ORGANIC COMPOUNDS INHIBIT HUMAN AND RAT NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS EXPRESSED IN XENOPUS OOCYTES.

EPA Science Inventory

This manuscript provides evidence to indicate that rats and humans are equally sensitive at the pharmacodynamic level to effects of volatile organic compounds.

? This manuscript also presents novel data that provides a plausible mechanism, disruption of ion channel functi...

Current Status of Infrared Technology

NASA Astrophysics Data System (ADS)

Tsunawaki, Yoshiaki; Hangyo, Masanori; Hiromoto, Norihisa; Horinaka, Hiromichi

Infrared sience and technology has been contributing to the four important national priority researches which are nano-, bio-, information- and environmental technologies. In this manuscript we discuss the current status of the infrared science and technology as well as its crucial role in the four technologies.

Psychological Risk Factors in Headache

PubMed Central

Nicholson, Robert A.; Houle, Timothy T.; Rhudy, Jamie L.; Norton, Peter J.

2008-01-01

Headache is a chronic disease that occurs with varying frequency and results in varying levels of disability. To date, the majority of research and clinical focus has been on the role of biological factors in headache and headache-related disability. However, reliance on a purely biomedical model of headache does not account for all aspects of headache and associated disability. Using a biopsychosocial framework, the current manuscript expands the view of what factors influence headache by considering the role psychological (i.e., cognitive and affective) factors have in the development, course, and consequences of headache. The manuscript initially reviews evidence showing that neural circuits responsible for cognitive–affective phenomena are highly interconnected with the circuitry responsible for headache pain. The manuscript then reviews the influence cognitions (locus of control and self-efficacy) and negative affect (depression, anxiety, and anger) have on the development of headache attacks, perception of headache pain, adherence to prescribed treatment, headache treatment outcome, and headache-related disability. The manuscript concludes with a discussion of the clinical implications of considering psychological factors when treating headache. PMID:17371358

Can editors save peer review from peer reviewers?

PubMed

D'Andrea, Rafael; O'Dwyer, James P

2017-01-01

Peer review is the gold standard for scientific communication, but its ability to guarantee the quality of published research remains difficult to verify. Recent modeling studies suggest that peer review is sensitive to reviewer misbehavior, and it has been claimed that referees who sabotage work they perceive as competition may severely undermine the quality of publications. Here we examine which aspects of suboptimal reviewing practices most strongly impact quality, and test different mitigating strategies that editors may employ to counter them. We find that the biggest hazard to the quality of published literature is not selfish rejection of high-quality manuscripts but indifferent acceptance of low-quality ones. Bypassing or blacklisting bad reviewers and consulting additional reviewers to settle disagreements can reduce but not eliminate the impact. The other editorial strategies we tested do not significantly improve quality, but pairing manuscripts to reviewers unlikely to selfishly reject them and allowing revision of rejected manuscripts minimize rejection of above-average manuscripts. In its current form, peer review offers few incentives for impartial reviewing efforts. Editors can help, but structural changes are more likely to have a stronger impact.

Trace elements in natural azurite pigments found in illuminated manuscript leaves investigated by synchrotron x-ray fluorescence and diffraction mapping

NASA Astrophysics Data System (ADS)

Smieska, Louisa M.; Mullett, Ruth; Ferri, Laurent; Woll, Arthur R.

2017-07-01

We present trace-element and composition analysis of azurite pigments in six illuminated manuscript leaves, dating from the thirteenth to sixteenth century, using synchrotron-based, large-area x-ray fluorescence (SR-XRF) and diffraction (SR-XRD) mapping. SR-XRF mapping reveals several trace elements correlated with azurite, including arsenic, zirconium, antimony, barium, and bismuth, that appear in multiple manuscripts but were not always detected by point XRF. Within some manuscript leaves, variations in the concentration of trace elements associated with azurite coincide with distinct regions of the illuminations, suggesting systematic differences in azurite preparation or purification. Variations of the trace element concentrations in azurite are greater among different manuscript leaves than the variations within each individual leaf, suggesting the possibility that such impurities reflect distinct mineralogical/geologic sources. SR-XRD maps collected simultaneously with the SR-XRF maps confirm the identification of azurite regions and are consistent with impurities found in natural mineral sources of azurite. In general, our results suggest the feasibility of using azurite trace element analysis for provenance studies of illuminated manuscript fragments, and demonstrate the value of XRF mapping in non-destructive determination of trace element concentrations within a single pigment.

Annotated bibliography of selected publications, through 1996, Cheyenne municipal well field areas, Cheyenne, Wyoming

USGS Publications Warehouse

Ogle, K.M.; Jordan, B.J.

1997-01-01

Annotated bibliographies for 55 hydrology and geology manuscripts pertaining to the Cheyenne municipal wells fields are listed in this report. For each manuscript, a citation is provided, a summaryparagraph is presented, key words are listed, and a location of the report is given. The report lists manuscripts, conference proceedings, and guidebooks published by the U. S. Geological Survey, State of Wyoming, Geological Society of America, Wyoming State Geological Survey,private consultants, and University of Wyoming.Information on geological formations, structural geology, aquifer characteristics, water levels, well- field production, water-demand projections, and water quality is included in the manuscripts. The Cheyenne Board of Public Utilities, the University of Wyoming, and the U. S. Geological Surveycooperatively produced this annotated bibliography to allow easy access and efficient utilization of existing data. The manuscripts were authored between 1910 and 1996, reflecting work completed over a long period of development in the Cheyenne, Wyoming area. Some manuscripts did not receive broad distribution and indexing, thus they have been difficult to locate in the past. By having the references and summaries within one report, time and effort to gather previous study results will be minimized.

Regulation of Glucose Transport in Quiescent, Lactating, and Neoplastic Mammary Epithelia

DTIC Science & Technology

2000-10-01

Manuscripts, Abstracts, Presentations Manuscripts 1. Nemeth, BN, Tsang, ST, Geske , RS, Haney, PM. Golgi targeting of the GLUT 1 glucose transporter in...targeting in lactating mouse mammary gland. Mol. Biol. Cell 1997; 8, 307a (ASCB poster presentation). 6. Geske , S, Haney, PM. Developmental regulation...1995. Characterization of a cis-Golgi matrix protein, GM130. JCellBiol 131:1715-1726. NEMETH BA, TSANG SWY, GESKE RS, HANEY PM, 2000. Golgi targeting

Plagiarism in submitted manuscripts: incidence, characteristics and optimization of screening-case study in a major specialty medical journal.

PubMed

Higgins, Janet R; Lin, Feng-Chang; Evans, James P

2016-01-01

Plagiarism is common and threatens the integrity of the scientific literature. However, its detection is time consuming and difficult, presenting challenges to editors and publishers who are entrusted with ensuring the integrity of published literature. In this study, the extent of plagiarism in manuscripts submitted to a major specialty medical journal was documented. We manually curated submitted manuscripts and deemed an article contained plagiarism if one sentence had 80 % of the words copied from another published paper. Commercial plagiarism detection software was utilized and its use was optimized. In 400 consecutively submitted manuscripts, 17 % of submissions contained unacceptable levels of plagiarized material with 82 % of plagiarized manuscripts submitted from countries where English was not an official language. Using the most commonly employed commercial plagiarism detection software, sensitivity and specificity were studied with regard to the generated plagiarism score. The cutoff score maximizing both sensitivity and specificity was 15 % (sensitivity 84.8 % and specificity 80.5 %). Plagiarism was a common occurrence among manuscripts submitted for publication to a major American specialty medical journal and most manuscripts with plagiarized material were submitted from countries in which English was not an official language. The use of commercial plagiarism detection software can be optimized by selecting a cutoff score that reflects desired sensitivity and specificity.

Canadian Pharmacy Practice Residents’ Projects: Publication Rates and Study Characteristics

PubMed Central

Hung, Michelle; Duffett, Mark

2013-01-01

Background: Research projects are a key component of pharmacy residents’ education. Projects represent both a large investment of effort for each resident (up to 10 weeks over the residency year) and a large body of research (given that there are currently over 150 residency positions in Canada annually). Publication of results is a vital part of the dissemination of information gleaned from these projects. Objectives: To determine the publication rate for research projects performed under the auspices of accredited English-language hospital pharmacy residency programs in Canada and to describe the study characteristics of residency projects performed in Ontario from 1999/2000 to 2008/2009. Methods: Lists of residents and project titles for the period of interest were obtained from residency coordinators. PubMed, CINAHL, the Canadian Journal of Hospital Pharmacy, and Google were searched for evidence of publication of each project identified, as an abstract or presentation at a meeting, a letter to the editor, or a full-text manuscript. The library holdings of the University of Toronto were reviewed to determine study characteristics of the Ontario residency projects. Results: For the objective of this study relating to publication rate, 518 projects were included. The overall publication rate was 32.2% (60 [35.9%] as abstracts and 107 [64.1%] as full-text manuscripts). Publication in pharmacy-specific journals (66 [61.7%] of 107 full-text manuscripts) was more frequent than publication in non-pharmacy-specific journals. The publication rate of projects as full-text manuscripts remained stable over time. Of the 202 Ontario residency projects archived in the University of Toronto’s library, most were cohort studies (83 [41.1%]), and the most common topic was efficacy and/or safety of a medication (46 [22.8%]). Conclusions: Most hospital pharmacy residents’ projects were unpublished, and the publication rate of projects as full-text manuscripts has not increased over time. Most projects were observational studies. Increasing publication rates and creating a central database or repository of residency projects would increase the dissemination and accessibility of residents’ research. PMID:23616672

Environmental impact of PV cell waste scenario.

PubMed

Bogacka, M; Pikoń, K; Landrat, M

2017-12-01

Rapid growth of the volume of waste from PV cells is expected in the following years. The problem of its utilization seems to be the most important issue for future waste management systems. The environmental impacts of the PV recycling scenario are presented in the manuscript. The analysis is based on the LCA approach and the average data available in specialized databases for silicon standard PV cell is used. The functional unit includes parameters like: efficiency, composition, surface area. The discussion on the environmental impact change due to the location of the PV production and waste processing plants is presented in the manuscript. Additionally, the discussion on the environmental effect of substituting different energy resources with PV cells is presented in the manuscript. The analysis of the PV cell life cycle scenario presented in the article was performed using the SIMA PRO software and data from Ecoinvent 3.0 database together with additional data obtained from other sources. Copyright © 2017 Elsevier Ltd. All rights reserved.

Checklist of Standards Applicable to the Preservation of Archives and Manuscripts.

ERIC Educational Resources Information Center

Walch, Victoria Irons, Comp.

1990-01-01

Presents a checklist of more than 150 standards that have been identified by the Society of American Archivists (SAA) Task Force on Archival Standards as applicable to the preservation of archives and manuscripts. The organizations that developed the standards are described, and increased archival participation in the standards development process…

Conversion of Society for Maternal Fetal Medicine Abstract Presentations to Manuscript Publications

PubMed Central

Manuck, Tracy A.; Barbour, Kelli; Janicki, Lindsay; Blackwell, Sean C.; Berghella, Vincenzo

2015-01-01

Objective To evaluate the rate of conversion of Society for Maternal Fetal Medicine (SMFM) Annual Meeting abstract presentations to full manuscript publications over time. Methods Full manuscript publications corresponding to all SMFM oral abstracts 2003–2010 inclusive, and SMFM poster abstracts in 2003, 2005, 2007, and 2009 were manually searched in PubMed. An abstract was considered to ‘match’ a full publication if the abstract and publication titles as well as main methods and results were similar and the abstract first author was a publication author. In cases of uncertainty, the abstract-publication match was reviewed by a second physician researcher. Time to publication, publication rates over time, and publication rates among US vs. non-US authors were examined. PMID numbers were also collected to determine if >1 abstract contributed to a manuscript. Data were analyzed using Wilcoxon rank-sum, ANOVA, t-test, and logistic regression. Results 3,281 abstracts presented at SMFM over the study period, including 629 orals (63 main plenary, 64 fellows plenary, 502 concurrent), were reviewed. 1,780/3,281 (54.3%) were published, generating 1,582 unique publications. Oral abstracts had a consistently higher rate of conversion to publications vs. posters (77.1% vs. 48.8%, p<0.001). The median time to publication was 19 (IQR 9–36) months, and was significantly shorter for orals vs. posters (11 vs. 21 months, p<0.001). Over the study period, rates of publication of orals remained constant, but rates of publication of posters were lower in 2007 and 2009 compared to 2003 and 2005. Publications related to SMFM abstracts were published in 194 different journals, most commonly AJOG (39.8%), Obstet Gynecol (9.7%), and J Matern Fetal Neonatal Med (6.5%). Publication rates were higher if the abstract’s first author was affiliated with a non-US institution (64.8% vs. 51.1%, p<0.001) and if the abstract received an award (82.7% vs. 53.3%, p<0.001). In regression models, oral presentation at SMFM, first author affiliation with a non-US institution, submission for AJOG SMFM special issue, and year of abstract presentation at SMFM were associated with full manuscript publication. Conclusions Between 2003 and 2010, full manuscript publication rates of SMFM abstracts were high and consistent, and time to publication decreased/improved across the study period for oral presentations. PMID:25981850

Research summary

NASA Technical Reports Server (NTRS)

Siegmann, W. L.; Robertson, J. S.; Jacobson, M. J.

1993-01-01

The final report for progress during the period from 15 Nov. 1988 to 14 Nov. 1991 is presented. Research on methods for analysis of sound propagation through the atmosphere and on results obtained from application of our methods are summarized. Ten written documents of NASA research are listed, and these include publications, manuscripts accepted, submitted, or in preparation for publication, and reports. Twelve presentations of results, either at scientific conferences or at research or technical organizations, since the start of the grant period are indicated. Names of organizations to which software produced under the grant was distributed are provided, and the current arrangement whereby the software is being distributed to the scientific community is also described. Finally, the names of seven graduate students who worked on NASA research and received Rensselaer degrees during the grant period, along with their current employers are given.

Transitioning to an Intramedullary Lengthening and Compression Nail

PubMed Central

2017-01-01

Summary: The magnetic intramedullary lengthening nail is an innovative technology that allows for creative ways to treat difficult problems. The lengthening option has revolutionized femur fracture management with bone loss and malunion therapy. The compression version of this nail has provided a gradual method to compress nonunions and difficult fractures that may obviate the need for many current uses of external fixation. Three cases are presented in this manuscript demonstrating a new paradigm in the management of bone loss/shortening of the tibia and femur, and recalcitrant nonunions. PMID:28486284

Paracelsian Medicine and Theory of Generation in ‘Exterior homo’, a Manuscript Probably Authored by Jan Baptist Van Helmont (1579–1644)

PubMed Central

Hedesan, Georgiana D.

2014-01-01

This article discusses a Latin manuscript that can be found in the Jan Baptist Van Helmont (1579–1644) archives in Mechelen (Malines), Belgium. The manuscript bears no author and no title, and begins with the words ‘Exterior homo’, hence being referred by this provisional title in the analysis. Ecclesiastical prosecutors investigating Van Helmont for heresy in 1634 considered that it was written by him, but this was vehemently denied by the Flemish physician. The present article takes a first detailed look at the content of the treatise and ideas contained therein. It hence identifies the manuscript as belonging to a seventeenth-century physician influenced by the ideas of Theophrastus Paracelsus (1493–1541) and his interpreter Petrus Severinus (1542–1602), and containing a complex medical philosophy drawn on alchemical thought. Thus, the anonymous author presents a comprehensive view on the nature and structure of man, as well as an idiosyncratic theory of human generation. Following the analysis of the treatise, the article further compares it with the known works of J.B. Van Helmont, and finds that it is very similar to his ideas. Hence, the article concludes that it is ‘likely’ that the manuscript is indeed written by Van Helmont, although lack of direct evidence prevents certain attribution. PMID:25045180

Effect of traps on the charge transport in semiconducting polymer PCDTBT

NASA Astrophysics Data System (ADS)

Khan, Mohd Taukeer; Agrawal, Vikash; Almohammedi, Abdullah; Gupta, Vinay

2018-07-01

Organic semiconductors (OSCs) are nowadays called upon as promising candidates for next generation electronics devices. Due to disorder structure of these materials, a high density of traps are present in their energy band gap which affect the performance of these devices. In the present manuscript, we have investigated the role of traps on charge transport in PCDTBT thin film by measuring the temperature dependent J(V) characteristics in hole only device configuration. The obtained results were analyzed by space charge limited (SCL) conduction model. It has been found that the room temperature J(V) characteristics follow Mott-Gurney square law for trap-free SCL conduction. But below 278 K, the current increases according to trap-filling SCL law with traps distributed exponentially in the band gap of semiconductor. Furthermore, after reaching a crossover voltage of VC ∽ 12 V, all the traps filled by injected carriers and the trap-filling SCL current switch to trap-free SCL current. The hole mobility of trap-free SCL current is about one order higher as compared trap-filling SCL current and remains constant with temperature.

A Reply to the Commentaries on "School-wide PBIS: An Example of Applied Behavior Analysis Implemented at a Scale of Social Importance" by Horner and Sugai (2015): PBIS is Function over Form: The Clear Behavioral Roots and Opportunities the PBIS Framework presents to the Field of Behavior Analysis Moving Forward.

PubMed

Putnam, Robert F; Knoster, Tim

2016-03-01

In the previous issue of Behavior Analysis in Practice (May 2015), a special section of the journal was devoted to positive behavior intervention and support (PBIS). Horner and Sugai (2015) published a manuscript providing an overview of school-wide PBIS describing how PBIS is an example of applied behavior analysis at a scale of social importance. A number of manuscripts providing commentary on the Horner and Sugai manuscript were also published in this special section of the journal. This paper will review this PBIS manuscript along with the associated commentaries published in the May 2015 special section.

Discrepancies Between Plastic Surgery Meeting Abstracts and Subsequent Full-Length Manuscript Publications.

PubMed

Denadai, Rafael; Araujo, Gustavo Henrique; Pinho, Andre Silveira; Denadai, Rodrigo; Samartine, Hugo; Raposo-Amaral, Cassio Eduardo

2016-10-01

The purpose of this bibliometric study was to assess the discrepancies between plastic surgery meeting abstracts and subsequent full-length manuscript publications. Abstracts presented at the Brazilian Congress of Plastic Surgery from 2010 to 2011 were compared with matching manuscript publications. Discrepancies between the abstract and the subsequent manuscript were categorized as major (changes in the purpose, methods, study design, sample size, statistical analysis, results, and conclusions) and minor (changes in the title and authorship) variations. The overall discrepancy rate was 96 %, with at least one major (76 %) and/or minor (96 %) variation. There were inconsistencies between the study title (56 %), authorship (92 %), purpose (6 %), methods (20 %), study design (36 %), sample size (51.2 %), statistical analysis (14 %), results (20 %), and conclusions (8 %) of manuscripts compared with their corresponding meeting abstracts. As changes occur before manuscript publication of plastic surgery meeting abstracts, caution should be exercised in referencing abstracts or altering surgical practices based on abstracts' content. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Missing data in trauma registries: A systematic review.

PubMed

Shivasabesan, Gowri; Mitra, Biswadev; O'Reilly, Gerard M

2018-03-30

Trauma registries play an integral role in trauma systems but their valid use hinges on data quality. The aim of this study was to determine, among contemporary publications using trauma registry data, the level of reporting of data completeness and the methods used to deal with missing data. A systematic review was conducted of all trauma registry-based manuscripts published from 01 January 2015 to current date (17 March 2017). Studies were identified by searching MEDLINE, EMBASE, and CINAHL using relevant subject headings and keywords. Included manuscripts were evaluated based on previously published recommendations regarding the reporting and discussion of missing data. Manuscripts were graded on their degree of characterization of such observations. In addition, the methods used to manage missing data were examined. There were 539 manuscripts that met inclusion criteria. Among these, 208 (38.6%) manuscripts did not mention data completeness and 88 (16.3%) mentioned missing data but did not quantify the extent. Only a handful (n = 26; 4.8%) quantified the 'missingness' of all variables. Most articles (n = 477; 88.5%) contained no details such as a comparison between patient characteristics in cohorts with and without missing data. Of the 331 articles which made at least some mention of data completeness, the method of managing missing data was unknown in 34 (10.3%). When method(s) to handle missing data were identified, 234 (78.8%) manuscripts used complete case analysis only, 18 (6.1%) used multiple imputation only and 34 (11.4%) used a combination of these. Most manuscripts using trauma registry data did not quantify the extent of missing data for any variables and contained minimal discussion regarding missingness. Out of the studies which identified a method of managing missing data, most used complete case analysis, a method that may bias results. The lack of standardization in the reporting and management of missing data questions the validity of conclusions from research based on trauma registry data. Copyright © 2018 Elsevier Ltd. All rights reserved.

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

PubMed Central

Lizcano, Fernando; Garcia, Jeison

2012-01-01

The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript. PMID:24280700

Advice on Writing a Scientific Paper

NASA Astrophysics Data System (ADS)

Sterken, C.

2006-04-01

What makes one author a good communicator and another a poor one? What turns out one manuscript a swift editorial task, and another an editorial nightmare? Based on direct experience from the manuscripts of the lectures and papers presented during this school, advice is given on what to do and on what to avoid when writing a scientific paper. Some feedback recommendation is also provided on how to prepare manuscripts, handle copyright and permissions to reproduce, how to anticipate plagiarism, how to deal with editors and referees, and how to avoid common errors. A few illustrations of English grammar and style for the foreign author are given.

Improving publication rates in a collaborative clinical trials research network.

PubMed

Archer, Stephanie Wilson; Carlo, Waldemar A; Truog, William E; Stevenson, David K; Van Meurs, Krisa P; Sánchez, Pablo J; Das, Abhik; Devaskar, Uday; Nelin, Leif D; Petrie Huitema, Carolyn M; Crawford, Margaret M; Higgins, Rosemary D

2016-10-01

Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network's (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. Data from 1991 to 2015 were analyzed to determine effectiveness of these policy changes. The NRN has achieved an overall publication rate of 78% for abstracts. For 1990-2002, of 137 abstracts presented, 43 (31%) were published within 2 years; for 2003-2009, after the manuscript completion policy was instituted, of 140 abstracts presented, 68 (49%) were published within 2 years. Following the effort in 2010, the rate increased to 64%. The NRN surpassed reported rates by developing a comprehensive process, holding investigators accountable and tracking abstracts from presentation to publication. Copyright © 2016. Published by Elsevier Inc.

Improving publication rates in a collaborative clinical trials research network

PubMed Central

Archer, Stephanie Wilson; Carlo, Waldemar A.; Truog, William E.; Stevenson, David K.; Van Meurs, Krisa P.; Sánchez, Pablo J.; Das, Abhik; Devaskar, Uday; Nelin, Leif D.; Petrie Huitema, Carolyn M.; Crawford, Margaret M.; Higgins, Rosemary D.

2016-01-01

Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network’s (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. Data from 1991 to 2015 were analyzed to determine effectiveness of these policy changes. The NRN has achieved an overall publication rate of 78% for abstracts. For 1990–2002, of 137 abstracts presented, 43 (31%) were published within 2 years; for 2003–2009, after the manuscript completion policy was instituted, of 140 abstracts presented, 68 (49%) were published within 2 years. Following the effort in 2010, the rate increased to 64%. The NRN surpassed reported rates by developing a comprehensive process, holding investigators accountable and tracking abstracts from presentation to publication. PMID:27423510

Association of a Biweekly Research Workgroup With Enhanced Resident Research Productivity.

PubMed

Brackmann, Melissa; Reynolds, R Kevin; Uppal, Shitanshu; McLean, Karen

2016-09-01

Almost all residency programs require a resident research project, yet teaching and mentoring of the required skills are often lacking. We established an every-other-week gynecologic oncology research workgroup at our institution for obstetrics and gynecology faculty, fellows, and residents with the goal of increasing resident research education, involvement, and productivity. An informal, discussion-style format was adopted as a forum for brainstorming research ideas, formulating study protocols, and collaborating on institutional review board submissions. Additional aims included editorial feedback on abstracts and manuscripts as well as oral presentation preparation. The academic productivity of trainees mentored by the gynecologic oncology division was queried for 27 months before and 27 months after workgroup initiation, specifically assessing resident involvement in institutional review board submission, abstract presentation, and manuscript preparation. Institution of our workgroup was associated with a dramatic increase in resident research output, including manuscript preparation and presentations at national meetings. We describe our experience because it may benefit other residency programs wishing to improve both resident research education and productivity.

MJMS at the Dawn of Its Electronic Era

PubMed Central

Dewiputri, Wan Ilma; Mohamad, Irfan

2011-01-01

This special editorial assessed the recent developments in Malaysian Journal of Medical Sciences (MJMS) and examined the characteristics of the submission, peer review, and publication processes for MJMS. This retrospective analysis used information about the manuscripts submitted to MJMS during the one-year period (from 1 June 2010 to 31 May 2010) since the start of current online submission and review system (ScholarOne™ Manuscripts, Thomson Reuters). In addition, we also discussed the future directions of MJMS. Finally, we would like to recommend an annual internal audit for MJMS, which is very useful to monitor the growth of this journal progressively. PMID:22135566

Current Concepts in Orthopedic Management of Multiple Trauma

PubMed Central

Kucukdurmaz, Fatih; Alijanipour, Pouya

2015-01-01

Multiple trauma patients frequently present challenging clinical scenarios with musculoskeletal injuries being the most common indications for surgical procedures in these patients. Despite our substantial knowledge, a universally approved objective definition for “multiple trauma” is yet to be delineated. Several controversial aspects of economics, pathophysiology, animal models, diagnosis, management and outcome of patients with multiple trauma have recently been explored and although some progress has been made, it seems that the available evidence is still inconclusive in some occasions. This manuscript revisits several current concepts of multiple trauma that have been the focus of recent investigation. We aim to provide the reader with an updated perspective based on the most recently published literature in the field of multiple trauma. PMID:26312111

Optimal management of genital herpes: current perspectives

PubMed Central

Sauerbrei, Andreas

2016-01-01

As one of the most common sexually transmitted diseases, genital herpes is a global medical problem with significant physical and psychological morbidity. Genital herpes is caused by herpes simplex virus type 1 or type 2 and can manifest as primary and/or recurrent infection. This manuscript provides an overview about the fundamental knowledge on the virus, its epidemiology, and infection. Furthermore, the current possibilities of antiviral therapeutic interventions and laboratory diagnosis of genital herpes as well as the present situation and perspectives for the treatment by novel antivirals and prevention of disease by vaccination are presented. Since the medical management of patients with genital herpes simplex virus infection is often unsatisfactory, this review aims at all physicians and health professionals who are involved in the care of patients with genital herpes. The information provided would help to improve the counseling of affected patients and to optimize the diagnosis, treatment, and prevention of this particular disease. PMID:27358569

Optimal management of genital herpes: current perspectives.

PubMed

Sauerbrei, Andreas

2016-01-01

As one of the most common sexually transmitted diseases, genital herpes is a global medical problem with significant physical and psychological morbidity. Genital herpes is caused by herpes simplex virus type 1 or type 2 and can manifest as primary and/or recurrent infection. This manuscript provides an overview about the fundamental knowledge on the virus, its epidemiology, and infection. Furthermore, the current possibilities of antiviral therapeutic interventions and laboratory diagnosis of genital herpes as well as the present situation and perspectives for the treatment by novel antivirals and prevention of disease by vaccination are presented. Since the medical management of patients with genital herpes simplex virus infection is often unsatisfactory, this review aims at all physicians and health professionals who are involved in the care of patients with genital herpes. The information provided would help to improve the counseling of affected patients and to optimize the diagnosis, treatment, and prevention of this particular disease.

Conversion of Society for Maternal-Fetal Medicine abstract presentations to manuscript publications.

PubMed

Manuck, Tracy A; Barbour, Kelli; Janicki, Lindsay; Blackwell, Sean C; Berghella, Vincenzo

2015-09-01

We sought to evaluate the rate of conversion of Society for Maternal-Fetal Medicine (SMFM) annual meeting abstract presentations to full manuscript publications over time. Full manuscript publications corresponding to all SMFM oral abstracts 2003 through 2010 inclusive, and SMFM poster abstracts in 2003, 2005, 2007, and 2009 were manually searched in PubMed. An abstract was considered to "match" a full publication if the abstract and publication titles as well as main methods and results were similar and the abstract first author was a publication author. In cases of uncertainty, the abstract-publication match was reviewed by a second physician researcher. Time to publication, publication rates over time, and publication rates among US vs non-US authors were examined. PubMed identification numbers were also collected to determine if >1 abstract contributed to a manuscript. Data were analyzed using Wilcoxon rank sum, analysis of variance, t test, and logistic regression. In all, 3281 abstracts presented at SMFM over the study period, including 629 orals (63 main plenary, 64 fellows plenary, 502 concurrent), were reviewed. Of 3281, 1780 (54.3%) were published, generating 1582 unique publications. Oral abstracts had a consistently higher rate of conversion to publications vs posters (77.1% vs 48.8%, P < .001). The median time to publication was 19 (interquartile range, 9-36) months, and was significantly shorter for orals vs posters (11 vs 21 months, P < .001). Over the study period, rates of publication of orals remained constant, but rates of publication of posters were lower in 2007 and 2009 compared to 2003 and 2005. Publications related to SMFM abstracts were published in 194 different journals, most commonly American Journal of Obstetrics and Gynecology (39.8%), Obstetrics and Gynecology (9.7%), and Journal of Maternal-Fetal and Neonatal Medicine (6.5%). Publication rates were higher if the abstract's first author was affiliated with a non-US institution (64.8% vs 51.1%, P < .001) and if the abstract received an award (82.7% vs 53.3%, P < .001). In regression models, oral presentation at SMFM, first author affiliation with a non-US institution, submission for American Journal of Obstetrics and Gynecology SMFM special issue, and year of abstract presentation at SMFM were associated with full manuscript publication. From 2003 through 2010, full manuscript publication rates of SMFM abstracts were high and consistent, and time to publication decreased/improved across the study period for oral presentations. Copyright © 2015 Elsevier Inc. All rights reserved.

Systematic review of interventional sickle cell trials registered in ClinicalTrials.gov.

PubMed

Lebensburger, Jeffrey D; Hilliard, Lee M; Pair, Lauren E; Oster, Robert; Howard, Thomas H; Cutter, Gary R

2015-12-01

The registry ClinicalTrials.gov was created to provide investigators and patients an accessible database of relevant clinical trials. To understand the state of sickle cell disease clinical trials, a comprehensive review of all 174 "closed," "interventional" sickle cell trials registered at ClinicalTrials.gov was completed in January 2015. The majority of registered sickle cell disease clinical trials listed an academic center as the primary sponsor and were an early phase trial. The primary outcome for sickle cell disease trials focused on pain (23%), bone marrow transplant (BMT) (13%), hydroxyurea (8%), iron overload (8%), and pulmonary hypertension (8%). A total of 52 trials were listed as terminated or withdrawn, including 25 (14% of all trials) terminated for failure to enroll participants. At the time of this review, only 19 trials uploaded results and 29 trials uploaded a manuscript in the ClinicalTrials.gov database. A systematic review of pubmed.gov revealed that only 35% of sickle cell studies completed prior to 2014 resulted in an identified manuscript. In comparison, of 80 thalassemia trials registered in ClinicalTrials.gov, four acknowledged failure to enroll participants as a reason for trial termination or withdrawal, and 48 trials (60%) completed prior to 2014 resulted in a currently identified manuscript. ClinicalTrials.gov can be an important database for investigators and patients with sickle cell disease to understand the current available research trials. To enhance the validity of the website, investigators must update their trial results and upload trial manuscripts into the database. This study, for the first time, quantifies outcomes of sickle cell disease trials and provides support to the belief that barriers exist to successful completion, publication, and dissemination of sickle cell trial results. © The Author(s) 2015.

Phytotherapy in medieval Serbian medicine according to the pharmacological manuscripts of the Chilandar Medical Codex (15-16th centuries).

PubMed

Jarić, Snežana; Mitrović, Miroslava; Djurdjević, Lola; Kostić, Olga; Gajić, Gordana; Pavlović, Dragana; Pavlović, Pavle

2011-09-01

The Chilandar Medical Codex is the most significant and best preserved medieval Serbian manuscript and collects together documents on European medical science from the 12th to 15th centuries. It represents the best-known and most complete example of a large collection of medical manuscripts from the Salerno-Montpellier school, written in the vernacular - something which does not exist among the majority of European nations. This paper presents the section of the Codex that deals with phytotherapy, which is contained within the pharmacological manuscripts. An analysis of their contents shows that out of a total of 167 recorded substances, 135 are of plant origin (81%), 13 animal origin (7.7%) and 19 inorganic (11.3%). The recorded plant species are categorised into 63 families, of which the most frequent are: Apiaceae (8.1%), Lamiaceae (8.1%), Asteraceae (5.9%), Rosaceae (5.9%) and Fabaceae (4.4%). All possible plant parts were used in treatments: the whole plant (6%), underground parts (13.7% - root, rhizome, bulb) and aerial parts (80.3% - stem, leaf, flower, buds, fruit, seeds). Of the plants quoted, the following are mentioned most frequently: Vitis sp. (120), Rosa canina (55), Olea europaea (45), Pistacia lentiscus (25), Saccharum officinarum (23), Artemisia absinthium (16) and Foeniculum vulgare (15). The contents of the pharmacological manuscripts of the Chilandar Medical Codex point to the sound contemporary knowledge of the diversity of plant species, their origins, habitat types, the levels of their healing powers, and when and how to gather them and prepare them, as well as the recommended dose for the treatment of specific illnesses. As these manuscripts contain not only common, lay terms for the plants, but also scientific, botanical ones, we can consider them the precursor to Serbian botany. Based on its contents and the way in which they are presented, it can be viewed not only as the first Serbian pharmacopeia, but first Slavic pharmacopeia, too, because similar manuscripts written in the vernacular did not exist during that period among the other Slavic nations, or even most European nations. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Distribution, habitat and adaptability of the genus Tapirus.

PubMed

García, Manolo J; Medici, Emília Patrícia; Naranjo, Eduardo J; Novarino, Wilson; Leonardo, Raquel S

2012-12-01

In this manuscript, as a starting point, the ancient and current distribution of the genus Tapirus are summarized, from its origins, apparently in Europe, to current ranges. Subsequently, original and current tapir habitats are described, as well as changes in ancient habitats. As the manuscript goes on, we examine the ways in which tapir species interact with their habitats and the main aspects of habitat use, spatial ecology and adaptability. Having reviewed the historic and current distribution of tapirs, as well as their use and selection of habitats, we introduce the concept of adaptability, considering that some of the tapir physiological characteristics and behavioral strategies can reduce the negative impact of habitat alteration and climate change. Finally, we provide recommendations for future research priorities. The conservation community is still missing important pieces of information for the effective conservation of tapirs and their remaining habitats in Central and South America and Southeast Asia. Reconstructing how tapir species reached their current distribution ranges, interpreting how they interact with their habitats and gathering information regarding the strategies they use to cope with habitat changes will increase our understanding about these animals and contribute to the development of conservation strategies. © 2012 Wiley Publishing Asia Pty Ltd, ISZS and IOZ/CAS.

Feeding and fueling the cities of the 21st century: Implications of declining energy quality and availability on the future growth and development of urban areas

NASA Astrophysics Data System (ADS)

Balogh, Stephen B.

This dissertation comprises an introduction and four manuscripts and is organized into two main sections: agriculture and energy. Three of the four manuscripts have been published, and the fourth has been accepted for publication pending minor revisions. The agriculture section contains the first two manuscripts: The first manuscript is an analysis of the edible energy efficiency of US and Canadian agriculture. The main conclusion of this study was that the efficiency of US agriculture increased three-fold from its low in 1970 to 2000. Yet agricultural efficiency has returned to the level of only the 1940s and has increased much more slowly over the past two decades. In the second manuscript, I quantify the food demand, production, and footprint for Onondaga County and Syracuse, NY over the past 100 years. I find that the county could meet only 15% of its food demand from current farmland. The energy equivalent to approximately 2.8 million barrels of oil is required each year to grow and ship the food demanded by county residents. The energy section contains manuscripts three and four. The third manuscript contains a quantification of the transitions in the energy metabolism over the growth and maturation of a US city, by comparing the urban respiration of fuels to the annual net primary production of the land in and immediately surrounding the city. The fourth manuscript examines the net energy and greenhouse gas balance for willow energy-crop systems, a potential source of local energy production. We estimate that an EROI of 18:1 to 43:1 is possible at the farm-gate. Finally, I assess the opportunities for improving the energy metabolism of the City of Syracuse, using both supply and demand-based interventions. After considering many of the interventions available to improve the energy metabolism of the city, no one technology or policy or combination thereof appears to have the potential to replace fossil fuel consumption or reduce energy demand to the level needed to supply the city's energy demand solely from renewable (solar-based) energy sources. Absent fossil fuels, the energy consumption in Syracuse would have to contract by at least 64%.

The Seemingly Quixotic Pursuit of a Cumulative Psychological Science: Introduction to the Special Issue

PubMed Central

Curran, Patrick J.

2009-01-01

The following manuscript is the final accepted manuscript. It has not been subjected to the final copyediting, fact-checking, and proofreading required for formal publication. It is not the definitive, publisher-authenticated version. The American Psychological Association and its Council of Editors disclaim any responsibility or liabilities for errors or omissions of this manuscript version, any version derived from this manuscript by NIH, or other third parties. The published version is available at www.apa.org/journals/met. The goal of any empirical science is to pursue the construction of a cumulative base of knowledge upon which the future of the science may be built. However, there is mixed evidence that the science of psychology can accurately be characterized by such a cumulative progression. Indeed, some argue that the development of a truly cumulative psychological science is not possible using the current paradigms of hypothesis testing in single-study designs. The author explores this controversy as a framework to introduce the six papers that make up this special issue that is focused on the integration of data and empirical findings across multiple studies. The author proposes that the methods and techniques described in this set of papers can significantly propel us forward in our ongoing quest to build a cumulative psychological science. PMID:19485622

The effects of embodied rhythm and robotic interventions on the spontaneous and responsive verbal communication skills of children with Autism Spectrum Disorder (ASD): A further outcome of a pilot randomized controlled trial

PubMed Central

Srinivasan, Sudha M.; Eigsti, Inge-Marie; Gifford, Timothy; Bhat, Anjana N.

2016-01-01

The current manuscript is the second in a mini-series of manuscripts reporting the effects of alternative, movement-based, rhythm and robotic interventions on the social communication skills of 36 school-age children with ASD. This pilot randomized controlled trial compared the effects of 8-weeks of rhythm and robotic interventions to those of a standard-of-care, comparison intervention. The first manuscript reported intervention effects on the spontaneous and responsive social attention skills of children. In this manuscript, we report intervention effects on the spontaneous and responsive verbal communication skills of children. Communication skills were assessed within a standardized test of responsive communication during the pretest and posttest as well as using training-specific measures of social verbalization during early, mid, and late training sessions. The rhythm and comparison groups improved on the standardized test in the posttest compared to the pretest. The rhythm and robot groups increased levels of social verbalization across training sessions. Movement-based and stationary contexts afforded different types and amounts of communication in children with ASD. Overall, movement-based interventions are a promising tool to enhance verbal and non-verbal communication skills in children with ASD. PMID:27668011

Weaving the native web: using social network analysis to demonstrate the value of a minority career development program.

PubMed

Buchwald, Dedra; Dick, Rhonda Wiegman

2011-06-01

American Indian and Alaska Native scientists are consistently among the most underrepresented minority groups in health research. The authors used social network analysis (SNA) to evaluate the Native Investigator Development Program (NIDP), a career development program for junior Native researchers established as a collaboration between the University of Washington and the University of Colorado Denver. The study focused on 29 trainees and mentors who participated in the NIDP. Data were collected on manuscripts and grant proposals produced by participants from 1998 to 2007. Information on authorship of manuscripts and collaborations on grant applications was used to conduct social network analyses with three measures of centrality and one measure of network reach. Both visual and quantitative analyses were performed. Participants in the NIDP collaborated on 106 manuscripts and 83 grant applications. Although three highly connected individuals, with critical and central roles in the program, accounted for much of the richness of the network, both current core faculty and "graduates" of the program were heavily involved in collaborations on manuscripts and grants. This study's innovative application of SNA demonstrates that collaborative relationships can be an important outcome of career development programs for minority investigators and that an analysis of these relationships can provide a more complete assessment of the value of such programs.

The effects of embodied rhythm and robotic interventions on the spontaneous and responsive verbal communication skills of children with Autism Spectrum Disorder (ASD): A further outcome of a pilot randomized controlled trial.

PubMed

Srinivasan, Sudha M; Eigsti, Inge-Marie; Gifford, Timothy; Bhat, Anjana N

2016-07-01

The current manuscript is the second in a mini-series of manuscripts reporting the effects of alternative, movement-based, rhythm and robotic interventions on the social communication skills of 36 school-age children with ASD. This pilot randomized controlled trial compared the effects of 8-weeks of rhythm and robotic interventions to those of a standard-of-care, comparison intervention. The first manuscript reported intervention effects on the spontaneous and responsive social attention skills of children. In this manuscript, we report intervention effects on the spontaneous and responsive verbal communication skills of children. Communication skills were assessed within a standardized test of responsive communication during the pretest and posttest as well as using training-specific measures of social verbalization during early, mid, and late training sessions. The rhythm and comparison groups improved on the standardized test in the posttest compared to the pretest. The rhythm and robot groups increased levels of social verbalization across training sessions. Movement-based and stationary contexts afforded different types and amounts of communication in children with ASD. Overall, movement-based interventions are a promising tool to enhance verbal and non-verbal communication skills in children with ASD.

Estimating Pesticide Effects on Fecundity Rates of Wild Birds Using Current Laboratory Reproduction Tests

EPA Science Inventory

The manuscript reviews the issues concerning the use of results on pesticide effects from laboratory avian reproduction tests for estimating potential impacts of pesticides on fecundity rates in avian population models.

[Quality and integrity in the production and publication of scientific results: data trimming, manipulation and (self) plagiarism].

PubMed

Lüscher, T F

2014-08-01

The publication of scientific manuscripts is an essential part in the research process and in the attempt to produce novel knowledge: only what is published exists. It is the aim of research to produce reproducible and sustainable knowledge. Reproducible knowledge is based on precise observation, the use of modern methodologies and an appropriate statistical analysis. As a consequence, it must be the intention of any scientist to report the truth and nothing but the truth. This principle requires precision and honesty. Deviation from such a behavior may lead to scientific misconduct: It encompasses the use of inappropriate methods and/or statistics, double publication of data, sloppy data presentation and processing, up to data massaging, manipulation, data theft or fabrication. Famous examples can be found throughout the history of research but it appears that such behavior has recently become more common possibly due to excessive competition, the crucial role of grants for scientific productivity and funding as well as promotion. Accordingly, in the training of researchers it seems essential to emphasize the importance of precise data acquisition and analysis to ascertain reproducible data. Similarly, it must be assured that data sets are only published once, that authors have contributed technically and/or intellectually in an important manner and that the work of other scientists is cited appropriately. Editors and reviewers should carefully assess the quality of submitted manuscripts. In fact, it is the aim of the peer review process to assure as much as possible that the quality of submitted manuscripts meets current methodological as well as ethical standards.

Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms.

PubMed

Hermans, Andre; Abend, Andreas M; Kesisoglou, Filippos; Flanagan, Talia; Cohen, Michael J; Diaz, Dorys A; Mao, Y; Zhang, Limin; Webster, Gregory K; Lin, Yiqing; Hahn, David A; Coutant, Carrie A; Grady, Haiyan

2017-11-01

This manuscript represents the perspective of the Dissolution Analytical Working Group of the IQ Consortium. The intent of this manuscript is to highlight the challenges of, and to provide a recommendation on, the development of clinically relevant dissolution specifications (CRS) for immediate release (IR) solid oral dosage forms. A roadmap toward the development of CRS for IR products containing active ingredients with a non-narrow therapeutic window is discussed, within the context of mechanistic dissolution understanding, supported by in-human pharmacokinetic (PK) data. Two case studies present potential outcomes of following the CRS roadmap and setting dissolution specifications. These cases reveal some benefits and challenges of pursuing CRS with additional PK data, in light of current regulatory positions, including that of the US Food and Drug Administration (FDA), who generally favor this approach, but with the understanding that both industry and regulatory agency perspectives are still evolving in this relatively new field. The CRS roadmap discussed in this manuscript also describes a way to develop clinically relevant dissolution specifications based primarily on dissolution data for batches used in pivotal clinical studies, acknowledging that not all IR product development efforts need to be supported by additional PK studies, albeit with the associated risk of potentially unnecessarily tight manufacturing controls. Recommendations are provided on what stages during the life cycle investment into in vivo studies may be valuable. Finally, the opportunities for CRS within the context of post-approval changes, Modeling and Simulation (M&S), and the application of biowaivers, are briefly discussed.

Behind the Spam: A ``Spectral Analysis'' of Predatory Publishers

NASA Astrophysics Data System (ADS)

Beall, Jeffrey

2016-10-01

Most researchers today are bombarded with spam email solicitations from questionable scholarly publishers. These emails solicit article manuscripts, editorial board service, and even ad hoc peer reviews. These ``predatory'' publishers exploit the scholarly publishing process, patterning themselves after legitimate scholarly publishers yet performing little or no peer review and quickly accepting submitted manuscripts and collecting fees from submitting authors. These counterfeit publishers and journals have published much junk science? especially in the field of cosmology? threatening the integrity of the academic record. This paper examines the current state of predatory publishing and advises researchers how to navigate scholarly publishing to best avoid predatory publishers and other scholarly publishing-related perils.

Historical Evolution of NASA Standard Materials Testing with Hypergolic Propellants and Ammonia (NASA Standard 6001 Test 15)

NASA Technical Reports Server (NTRS)

Greene, Benjamin; McClure, Mark B.

2012-01-01

The NASA Johnson Space Center White Sands Test Facility (WSTF) has performed testing of hazardous and reactive aerospace fluids, including hypergolic propellants, with materials since the 1960s with the Apollo program. Amongst other test activities, Test 15 is a NASA standard test for evaluating the reactivity of materials with selected aerospace fluids, in particular hydrazine, monomethylhydrazine, uns-dimethylhydrazine, Aerozine 50, dinitrogen tetroxide oxidizers, and ammonia. This manuscript provides an overview of the history of Test 15 over a timeline ranging from prior to its development and first implementation as a NASA standard test in 1974 to its current refinement. Precursor documents to NASA standard tests, as they are currently known, are reviewed. A related supplementary test, international standardization, and enhancements to Test 15 are also discussed. Because WSTF was instrumental in the development and implementation of Test 15, WSTF experience and practices are referred to in this manuscript.

Industrial bioprocesses: beyond routine applications of established methodologies.

PubMed

Junker, Beth

2010-04-15

The subject matter of manuscripts by industrial authors has primarily focused on elements with perceived commercial or regulatory significance. Once published, this information interacted and ultimately influenced manuscripts from authors of other affiliations, creating the rapid advancements that culminated in the current multi-billion dollar worldwide biotechnology industry. This paper discusses trends in "solely industrial" articles published in the specific journal of Biotechnology and Bioengineering over the past five decades of this journal's lifetime. "Solely industrial" articles were defined as papers in which all the authors were affiliated with industry. Data were gathered concerning "solely industrial" article distribution and frequency, authoring companies, subject classification, and category distribution. Selected articles and their impact were related to current and past technology milestones as well as associated challenges. Suggestions for areas of greater emphasis to influence the number and subject matter of "solely industrial" articles for the journal's sixth decade were offered for consideration.

The Electronic Astrophysical Journal Letters Project

NASA Astrophysics Data System (ADS)

Dalterio, H. J.; Boyce, P. B.; Biemesderfer, C.; Warnock, A., III; Owens, E.; Fullton, J.

The American Astronomical Society has developed a comprehensive system for the electronic dissemination of refereed astronomical research results. Our current focus is the production of an electronic version of the Astrophysical Journal Letters. With the help of a recent National Science Foundation grant, we have developed a system that includes: LATEX-based manuscript preparation, electronic submission, peer review, production, development of a database of SGML-tagged manuscripts, collection of page charges and other fees, and electronic manuscript storage and delivery. Delivery options include World-Wide Web access through HTML browsers such as Mosaic and Netscape, an email gateway, and a stand-alone client accessible through astronomical software packages such as IRAF. Our goal is to increase the access and usefulness of the journal by providing enhanced features such as faster publication, advanced search capabilities, forward and backward referencing, links to underlying data and links to adjunct materials in a variety of media. We have based our journal on open standards and freely available network tools wherever possible.

Teachers' sick leave due to mental and behavioral disorders and return to work.

PubMed

Silva, Amanda Aparecida; Fischer, Frida Marina

2012-01-01

This manuscript presents a review of the literature about medical leaves due to mental and behavioral disorders and return to work of teachers. There are scarce published manuscripts. Most articles relate with prevalence of mental disorders and factors associated with the work organization, and did not mention intervention proposals and or changes in the work organization and teaching work. Proposed actions are discussed.

On the identification of folium and orchil on illuminated manuscripts

NASA Astrophysics Data System (ADS)

Aceto, Maurizio; Calà, Elisa; Agostino, Angelo; Fenoglio, Gaia; Idone, Ambra; Porter, Cheryl; Gulmini, Monica

2017-01-01

The identification of the two purple dyes folium and orchil has rarely been reported in the analysis of painted artworks, especially when analysing illuminated manuscripts. This is not consistent with the fact that ancient literary sources suggested their use as substitutes for the more expensive Tyrian purple dye. By employing non-invasive spectroscopic techniques, the present work demonstrates that these dyes were actually widely used in the production of ancient manuscripts. By employing UV-visible diffuse reflectance spectrophotometry with optic fibres (FORS) and spectrofluorimetry, the abundant identification of both dyes on medieval manuscripts was performed by comparing the spectra recorded on ancient codices with those obtained on accurate replicas of dyed or painted parchment. Moreover, examples are also reported whereby the considered purple dyes were used in mixtures with other colourants. The overall information obtained here allowed us to define new boundaries for the time range in which orchil and folium dyes were used which is wider than previously thought, and to focus on their particular uses in the decoration of books.

Demetrius Cantemir: the first account of transabodominal approach to repair groin hernia.

PubMed

Nicolau, A E

2009-01-01

The first description of the transabdominal approach for hernia repair was written by Demetrius Cantemir, Prince of Moldavia and encyclopedic scholar, in his 1716 Latin manuscript "Incrementa et decrementa Aulae Othomaniae" ("The history of the Growth and Decay of the Ottoman Empire"). This manuscript was one of the most important in Eastern Europe at the time. It was first translated in English in 1734 by N. Tyndal, and all subsequent translations into various other languages were based on this english version. The original manuscript now belongs to the Houghton Library of Harvard University, where it was recently discovered in 1984 by V. Candea. Our article presents for the first time the complete account of the surgical procedure performed by Albanian physicians in the prince's palace in Constantinopol. The patient was the Prince's secretary. There is a detailed description of the operation, postoperative therapy and the medical course to recovery. The text presented is translated in English from Annotations of Volume Two, chapter four. We consider it worthwhile to present to the medical community this valuable but less known contribution to the history of medicine.

[Recommendations for the diagnosis, staging and treatment of pre-malignant lesions and pancreatic adenocarcinoma].

PubMed

Martin-Richard, Marta; Ginès, Angels; Ayuso, Juan Ramón; Sabater, Luis; Fabregat, Joan; Mendez, Ramiro; Fernández-Esparrach, Glòria; Molero, Xavier; Vaquero, Eva C; Cuatrecasas, Miriam; Ferrández, Antonio; Maurel, Joan

2016-11-18

Clinical management of adenocarcinoma of the pancreas is complex, and requires a multidisciplinary approach. The same applies for the premalignant lesions that are increasingly being diagnosed. The current document is an update on the diagnosis and management of premalignant lesions and adenocarcinoma of the pancreas. A conference to establish the basis of the literature review and manuscript redaction was organized by the Grupo Español Multidisciplinar en Cáncer Digestivo. Experts in the field from different specialties (Gastroenterology, Surgery, Radiology, Pathology, Medical Oncology and Radiation Oncology) met to prepare the present document. The current literature was reviewed and discussed, with subsequent deliberation on the evidence. Final recommendations were established in view of all the above. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

Toward precision medicine in primary biliary cholangitis.

PubMed

Carbone, Marco; Ronca, Vincenzo; Bruno, Savino; Invernizzi, Pietro; Mells, George F

2016-08-01

Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a 'one size fits all' approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zavarin, Mavrik; Joseph, C.

This progress report (Level 4 Milestone Number M4FT-16LL080303052) summarizes research conducted at Lawrence Livermore National Laboratory (LLNL) within the Crystalline Disposal R&D Activity Number FT-16LL080303051 and Crystalline International Collaborations Activity Number FT-16LL080303061. The focus of this research is the interaction of radionuclides with Engineered Barrier System (EBS) and host rock materials at various physico-chemical conditions relevant to subsurface repository environments. They include both chemical and physical processes such as solubility, sorption, and diffusion. The colloid-facilitated transport effort focused on preparation of a draft manuscript summarizing the state of knowledge and parameterization of colloid-facilitated transport mechanisms in support of reactive transportmore » and performance assessment models for generic crystalline repositories. This draft manuscript is being submitted as a level 3 milestone with LANL as the primary author. LLNL’s contribution to that effort is summarized only briefly in the present report. A manuscript summarizing long-term U(VI) diffusion experiments through bentonite backfill material was recently accepted for publication; the contents of that manuscript are summarized in the present report. The Np(IV) diffusion experiments were started mid-year and are ongoing. The completion of these experiments is planned for early FY17. Our progress in quantifying Np(IV) diffusion in bentonite backfill is summarized in the present report. Our involvement with the NEA TDB project was summarized in a recent Argillite Disposal activity report. It is not included in this report.« less

Beyond Dogma: From Diagnostic Controversies to Data About Pediatric Bipolar Disorder and Children with Chronic Irritability and Mood Dysregulation

PubMed Central

Dickstein, Daniel P.; Leibenluft, Ellen

2015-01-01

From the mid-1990s through the present, studies have demonstrated a significant rise in the numbers of children and adolescents diagnosed with bipolar disorder (BD). Why is this? The present manuscript reviews several possibilities, most notably ambiguity in the diagnostic criteria for mania and how they may apply to children with functionally-impairing irritability. Furthermore, we discuss ongoing phenomenological and affective neuroscience research approaches to address those children most on the fringes of our current psychiatric nosology. In summary, these studies suggest that BD youths may be distinguished on some measures from those with chronic irritability and severe mood dysregulation, although the two groups also have some shared deficits. PMID:22652929

JOURNAL CLUB: Plagiarism in Manuscripts Submitted to the AJR: Development of an Optimal Screening Algorithm and Management Pathways.

PubMed

Taylor, Donna B

2017-04-01

The objective of this study was to investigate the incidence of plagiarism in a sample of manuscripts submitted to the AJR using CrossCheck, develop an algorithm to identify significant plagiarism, and formulate management pathways. A sample of 110 of 1610 (6.8%) manuscripts submitted to AJR in 2014 in the categories of Original Research or Review were analyzed using CrossCheck and manual assessment. The overall similarity index (OSI), highest similarity score from a single source, whether duplication was from single or multiple origins, journal section, and presence or absence of referencing the source were recorded. The criteria outlined by the International Committee of Medical Journal Editors were the reference standard for identifying manuscripts containing plagiarism. Statistical analysis was used to develop a screening algorithm to maximize sensitivity and specificity for the detection of plagiarism. Criteria for defining the severity of plagiarism and management pathways based on the severity of the plagiarism were determined. Twelve manuscripts (10.9%) contained plagiarism. Nine had an OSI excluding quotations and references of less than 20%. In seven, the highest similarity score from a single source was less than 10%. The highest similarity score from a single source was the work of the same author or authors in nine. Common sections for duplication were the Materials and Methods, Discussion, and abstract. Referencing the original source was lacking in 11. Plagiarism was undetected at submission in five of these 12 articles; two had been accepted for publication. The most effective screening algorithm was to average the OSI including quotations and references and the highest similarity score from a single source and to submit manuscripts with an average value of more than 12% for further review. The current methods for detecting plagiarism are suboptimal. A new screening algorithm is proposed.

Reflections on Recruiting, Supporting, Retaining, Graduating, and Obtaining Employment for Doctoral Students from Diverse Backgrounds

ERIC Educational Resources Information Center

Dieker, Lisa; Wienke, Wilfred; Straub, Carrie; Finnegan, Lisa

2014-01-01

In this article, the authors provide a summary of the current techniques being used to recruit, retain, and support a diverse range of scholars, including students with disabilities, in a doctoral program. The manuscript provides a summary of the current need for leadership personnel who are scholars with knowledge in special education, general…

The Duke, the Soldier of Fortune, and a Rosicrucian Legacy: Exploring the Roles of Manuscripts in Early-Modern Alchemy.

PubMed

Zuber, Mike A

2018-05-01

By the time it was published in 1705, the Speculum Sapientiae claimed to have had a long history going back to 1672. However, the fact that exaggerated stories were commonplace in alchemical literature leads us to question its credibility. This paper explores the secret lives of this alchemical text prior to its print publication to clarify the roles of manuscripts in early-modern alchemy. Specifically, I argue that there were three aspects that could distinguish manuscript from print: provenance, materiality, and exclusivity. These can be seen at work in the fate of Johann Heinrich Vierordt, an itinerant alchemist and cavalry captain whose career is inextricably linked to the scribal dissemination of the Speculum Sapientiae. In addition to manuscript copies of that text at libraries across Europe, a significant cache of correspondence preserved in Gotha documents Vierordt's dealings with Duke Friedrich I of Saxe-Gotha. The verisimilitudinous provenance of Vierordt's alchemical secrets and tincture played a crucial role in allowing him to gain Friedrich's trust. Yet it was only after Vierordt presented him with a precious parchment manuscript of the Speculum Sapientiae that he truly succeeded in gaining the duke's patronage. Subsequently, reports of multiple conflicting copies surfacing in Amsterdam sealed Vierordt's fall from favour.

Disruption of Fibroblast Growth Factor Receptor (FGFR) Signaling as an Approach to Prostate Cancer Therapy

DTIC Science & Technology

2005-04-01

presented in tenth Annual Meeting of Association of Molecular Pathology and the abstract was published in the Journal of Molecular Diagnostics . The full...CDC25C Phosphatase Activity in Prostate Cancer: Correlation to Biochemical Recurrence. Journal of Molecular Diagnostics 2004, (6)4: 431. A manuscript in...receptor signaling. Clinical Cancer Research (in press). Acceptance letter for the above manuscript An abstract published in the Journal of Molecular

The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation (HCT): Defining the Unique Late Effects of Children undergoing HCT for Immune Deficiencies, Inherited Marrow Failure Disorders, and Hemoglobinopathies

PubMed Central

Dietz, Andrew C.; Duncan, Christine N.; Alter, Blanche P.; Bresters, Dorine; Cowan, Morton J.; Notarangelo, Luigi; Rosenberg, Philip S.; Shenoy, Shalini; Skinner, Roderick; Walters, Mark C.; Wagner, John; Baker, K. Scott; Pulsipher, Michael A.

2016-01-01

An international consensus conference sponsored by the Pediatric Blood and Marrow Transplant consortium entitled, “Late Effects Screening and Recommendations Following Allogeneic Hematopoietic Cell Transplant for Immune Deficiency and Non-malignant Hematologic Disease was held in Minneapolis, Minnesota on May 10–11, 2016. The purpose of the conference was to address the unmet need for a greater understanding of and the screening for long-term complications in the growing population of survivors of transplantation for nonmalignant disorders. The conference focused on transplantation for hemoglobinopathy, immune deficiency, and inherited bone marrow syndromes. A multidisciplinary group of experts in the disease areas and transplant late effects presented the current state of understanding of how the underlying disease, pretransplant therapies, and transplant related factors uniquely interact to influence the development of late toxicities. Recommendations were put forth by the group for the late effects screening of survivors of transplantation for these non-malignant disorders. The findings and recommendations that came from this conference will be presented in a series of six additional manuscripts in the upcoming months. In this manuscript we explore the need for screening practices specific to the survivors of transplantation for non-malignant diseases and the metholodologic challenges associated with the study of these patients. PMID:27737772

How to write an introduction section of a scientific article?

PubMed

Armağan, Abdullah

2013-09-01

An article primarily includes the following sections: introduction, materials and methods, results, discussion, and conclusion. Before writing the introduction, the main steps, the heading and the familiarity level of the readers should be considered. Writing should begin when the experimental system and the equipment are available. The introduction section comprises the first portion of the manuscript, and it should be written using the simple present tense. Additionally, abbreviations and explanations are included in this section. The main goal of the introduction is to convey basic information to the readers without obligating them to investigate previous publications and to provide clues as to the results of the present study. To do this, the subject of the article should be thoroughly reviewed, and the aim of the study should be clearly stated immediately after discussing the basic references. In this review, we aim to convey the principles of writing the introduction section of a manuscript to residents and young investigators who have just begun to write a manuscript.

Anxiety Among Adolescent Survivors of Pediatric Cancer.

PubMed

McDonnell, Glynnis A; Salley, Christina G; Barnett, Marie; DeRosa, Antonio P; Werk, Rachel S; Hourani, Allison; Hoekstra, Alyssa B; Ford, Jennifer S

2017-10-01

The purpose of this review was to synthesize current knowledge about anxiety among adolescent survivors of pediatric cancer and highlights areas for future research. Systematic literature searches were conducted in five databases for articles published anytime before December 28, 2015. Manuscripts were reviewed by a team of six coders. Included manuscripts reported outcomes relevant to anxiety, worry, and post-traumatic stress in survivors of pediatric cancer (age at the time of study: 10-22 years) who were off treatment. Twenty-four articles met inclusion criteria. Included results were categorized into the following domains: post-traumatic stress, anxiety, cancer-related worry, and interventions. With the exception of post-traumatic stress, there was little research about anxiety in this population; however, studies generally indicated that adolescent survivors of pediatric cancer are at elevated risk for anxiety, post-traumatic stress symptoms, and cancer-related worry. This review provides preliminary evidence that anxiety is a relevant, but understudied, psychosocial outcome for adolescent survivors of pediatric cancer. More research is needed to better understand the presentation of anxiety in this population, its effect on survivors' quality of life, and possible areas for intervention. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Imaging of neuro-cognitive performance in extreme Environments—A (p)review

NASA Astrophysics Data System (ADS)

Schneider, Stefan; Bubeev, Juri A.; Choukèr, Alexander; Morukov, Boris; Johannes, Bernd; Strüder, Heiko K.

2012-12-01

Living in extreme environments is accompanied by a number of stressors, which can be classified either as physiological stressors (e.g. microgravity, missing sunlight) or psychological stressors (e.g. confinement). From earth bound studies a negative impact of stress on mental health and cognitive performance is well known and both factors might impair mission success and mission safety during longer inhabitation of space. Accordingly there is the need to identify adequate countermeasures. Nevertheless causal research of neuro-cognitive impairments in space remains speculative due to missing possibilities of brain imaging. Furthermore the reliability of current psychological tests used to assess and monitor cognitive performance in extreme environments seems to be vulnerable due to a lack of compliance. With on-going plans of international space agencies to send people to moon and/or mars, this manuscript aims to summarize and review research attempts of the past two decades and to identify methodological shortcomings. Finally, following the guideline that research has no legacy for its own but must serve the self-concept and well-being of man, this manuscript presents a number of recommendations to enhance future neuro-cognitive research in extreme environments. A deeper insight into neuro-cognitive coherence is not only desirable to understand the effects of stress on mental health, which seems to be a major issue for our current society, and to develop adequate countermeasures but will also help to maintain and improve mission success and mission safety in manned space flight.

CONSUMPTION OF ANIMAL FOODS AND ENDOMETRIAL CANCER RISK: A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS

PubMed Central

Bandera, Elisa V.; Kushi, Lawrence H.; Moore, Dirk F.; Gifkins, Dina M.; McCullough, Marjorie L.

2008-01-01

This paper summarizes and quantifies the current evidence relating dietary intake of animal products and endometrial cancer. Literature searches were conducted to identify peer-reviewed manuscripts published up to December 2006. Twenty-two manuscripts from three cohort studies and 16 case-control studies were identified. One of these cohort studies evaluated only fried meat and another only milk consumption; they were not included in our meta-analyses. The third cohort study identified did not present exposure levels and could not be included in dose-response meta-analysis. This cohort study did not show an association with meat or red meat consumption. Random-effects dose-response summary estimates for case-control studies evaluating these foods were 1.26 (95% CI: 1.03–1.54) per 100 g/day of total meat, 1.51 (95% CI: 1.19–1.93) per 100 g/day of red meat, 1.03 (95% CI: 0.32–3.28) per 100 g/day of poultry, 1.04 (95% CI: 0.55–1.98) per 100 g/day of fish, and 0.97 (95% CI: 0.93–1.01) per serving of dairy. Our meta-analysis, based on case-control data, suggests that meat consumption, particularly red meat, increases endometrial cancer risk. The current literature does not support an association with dairy products, while the evidence is inconsistent for poultry, fish, and eggs. More studies, particularly prospective studies, are needed. PMID:17638104

28 CFR 551.81 - Manuscript preparation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Manuscript preparation. 551.81 Section 551.81 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MISCELLANEOUS Inmate Manuscripts § 551.81 Manuscript preparation. An inmate may prepare a manuscript for private...

28 CFR 551.81 - Manuscript preparation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Manuscript preparation. 551.81 Section 551.81 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MISCELLANEOUS Inmate Manuscripts § 551.81 Manuscript preparation. An inmate may prepare a manuscript for private...

28 CFR 551.81 - Manuscript preparation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Manuscript preparation. 551.81 Section 551.81 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MISCELLANEOUS Inmate Manuscripts § 551.81 Manuscript preparation. An inmate may prepare a manuscript for private...

28 CFR 551.81 - Manuscript preparation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Manuscript preparation. 551.81 Section 551.81 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MISCELLANEOUS Inmate Manuscripts § 551.81 Manuscript preparation. An inmate may prepare a manuscript for private...

28 CFR 551.81 - Manuscript preparation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Manuscript preparation. 551.81 Section 551.81 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MISCELLANEOUS Inmate Manuscripts § 551.81 Manuscript preparation. An inmate may prepare a manuscript for private...

Publication Rates for Oral Manuscript and Poster Presentations From the American College of Foot and Ankle Surgeons: 2010 to 2014.

PubMed

Rushing, Calvin J; Galan, Gabriel P; Ivankiv, Roman; Oxios, Adam J; Rathnayake, Viraj R; Ramil, Madelin C; Chussid, Fredric; Spinner, Steven M

2018-04-26

The American College of Foot and Ankle Surgeons (ACFAS) annual conference has served as a premiere platform to disseminate the latest innovations and research in the field of foot and ankle surgery. The quality of national society conferences is often assessed indirectly by analyzing the the journal publication rate of the abstracts presented. The purpose of this retrospective study was to assess the journal publication rate for abstracts (oral manuscripts and posters) accepted for presentation at the ACFAS conference from 2010 to 2014. All accepted abstracts from this period were compiled by the ACFAS office. PubMed, Google Scholar, and Scopus searches were performed using abstract titles and author names. Overall, the journal publication rate was 76.9% (83 of 108) for oral manuscripts and 23.2% (258 of 1113) for poster abstracts. The mean time to publication was 9.6 (range 0 to 44) months and 19.8 (range 0 to 66) months for oral and poster abstracts, respectively. The most common journal for abstract publication was The Journal of Foot and Ankle Surgery. Notably, the ACFAS oral manuscript publication rate from 2010 to 2014 (76.9%) exceeded its previously reported rate from 1999 to 2008 (67.5%) and the American Orthopaedic Foot and Ankle Society podium publication rate from 2008 to 2012 (73.7%). To the best of our knowledge, the publication incidence for oral abstracts presented at the ACFAS conference is now the highest reported of any national foot and ankle society conference to date. Copyright © 2017 The American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Asay-Davis, Xylar Storm

The project performed under this award, referred to from here on as CLARION (CoupLed simulations of Antarctic Ice-sheet/Ocean iNteractions), included important advances in two models of ice sheet and ocean interactions. Despite its short duration (one year), the project made significant progress on its three major foci. First, together with collaborator Daniel Martin at Lawrence Berkeley National Laboratory (LBNL), I developed the POPSICLES coupled ice sheet-ocean model to the point where it could perform a number of pan-Antarctic simulations under various forcing conditions. The results were presented at a number of major conferences and workshops worldwide, and are currently beingmore » incorporated into two manuscripts in preparation.« less

The value of β-blockers administration during recovery phase of dobutamine stress echocardiography: a review.

PubMed

Nguyen, James; Juneman, Elizabeth; Movahed, Mohammad Reza

2013-07-01

Dobutamine stress echocardiography (DSE) is a successful technique for detection of ischemia in patients with suspected coronary artery disease (CAD). There are some data that administration of β-blocker after peak infusion of dobutamine can improve sensitivity. The goal of this manuscript is to review the current literature in regard to the mechanism and accuracy of post-dobutamine β-blocker administration for ischemia detection. In this review, we present 2 case reports followed by detailed review of the literature. © 2013. This article is a U.S. Government work and is in the public domain in the USA.

Management of impulse control disorders in Parkinson's disease: Controversies and future approaches.

PubMed

Samuel, Michael; Rodriguez-Oroz, Maria; Antonini, Angelo; Brotchie, Jonathan M; Ray Chaudhuri, Kallol; Brown, Richard G; Galpern, Wendy R; Nirenberg, Melissa J; Okun, Michael S; Lang, Anthony E

2015-02-01

Impulse control disorders in Parkinson's disease are a group of impulsive behaviors most often associated with dopaminergic treatment. Presently, there is a lack of high quality evidence available to guide their management. This manuscript reviews current management strategies, before concentrating on the concept of dopamine agonist withdrawal syndrome and its implications for the management of impulse control disorders. Further, we focus on controversies, including the role of more recently available anti-parkinsonian drugs, and potential future approaches involving routes of drug delivery, nonpharmacological treatments (such as cognitive behavioral therapy and deep brain stimulation), and other as yet experimental strategies. © 2015 International Parkinson and Movement Disorder Society.

Impulse Control Disorders in Parkinson’s Disease:Management, Controversies, and Potential Approaches

PubMed Central

Samuel, M; Rodriguez-Oroz, M; Antonini, A; Brotchie, JM; Ray Chaudhuri, K; Brown, RG; Galpern, WR; Nirenberg, MJ; Okun, MS; Lang, AE

2016-01-01

Impulse control disorders in Parkinson’s disease are a group of impulsive behaviors most often associated with dopaminergic treatment. Presently, there is a lack of high quality evidence available to guide their management. This manuscript reviews current management strategies, before concentrating on the concept of dopamine agonist withdrawal syndrome and its implications for the management of impulse control disorders. Further, we focus on controversies including the role of more recently available anti-parkinsonian drugs, and potential future approaches involving routes of drug delivery, non-pharmacological treatments (such as cognitive behaviour therapy and deep brain stimulation), and other as yet experimental strategies. PMID:25607799

Weaving the Native Web: Using Social Network Analysis to Demonstrate the Value of a Minority Career Development Program

PubMed Central

Buchwald, Dedra; Dick, Rhonda Wiegman

2011-01-01

Purpose American Indian and Alaska Native scientists are consistently among the most underrepresented minority groups in health research. The authors used social network analysis (SNA) to evaluate the Native Investigator Development Program (NIDP), a career development program for junior Native researchers established as a collaboration between the University of Washington and the University of Colorado Denver. Method The study focused on 29 trainees and mentors who participated in the NIDP. Data were collected on manuscripts and grant proposals produced by participants from 1998 to 2007. Information on authorship of manuscripts and collaborations on grant applications was used to conduct social network analyses with 3 measures of centrality and 1 measure of network reach. Both visual and quantitative analyses were performed. Results Participants in the NIDP collaborated on 106 manuscripts and 83 grant applications. Although 3 highly connected individuals, with critical and central roles in the program, accounted for much of the richness of the network, both current core faculty and “graduates” of the program were heavily involved in collaborations on manuscripts and grants. Conclusions This study’s innovative application of SNA demonstrates that collaborative relationships can be an important outcome of career development programs for minority investigators, and that an analysis of these relationships can provide a more complete assessment of the value of such programs. PMID:21512364

Unveiling the Third Secret of Fátima: μ-XRF quantitative characterization and 2D elemental mapping

NASA Astrophysics Data System (ADS)

Manso, M.; Pessanha, S.; Guerra, M.; Figueirinhas, J. L.; Santos, J. P.; Carvalho, M. L.

2017-04-01

A set of five manuscripts written by Sister Lúcia between 1941 and 1944 were under study. Among them is the one that contains the description of the third part of the Secret of Fátima also known as the Third Secret of Fátima. In this work, a characterization of the paper and the ink used in these documents was achieved using micro-X-ray fluorescence spectrometry. Quantitative results were obtained for P, K, Ca, Fe, Cu and Zn, revealing different paper composition and Zn in the inks. 2D elemental maps confirmed that Zn was present in the five documents ink and that the manuscript revealing the Third Secret of Fátima contained no erasures or alteration attempts to the original manuscript.

Relationship Between Conflicts of Interest and Research Results

PubMed Central

Friedman, Lee S; Richter, Elihu D

2004-01-01

CONTEXT To date, research regarding the influence of conflicts of interest on the presentation of findings by researchers has been limited. OBJECTIVE To evaluate the sources of funding for published manuscripts, and association between reported findings and conflicts of interest. METHODS Data from both print and electronic issues of The New England Journal of Medicine (NEJM) and The Journal of the American Medical Association (JAMA) were analyzed for sources of funding, areas of investigation, conflict of interest (COI), and presentation of results. We reviewed all original manuscripts published during the year 2001 within NEJM (N = 193) and JAMA (N = 205). We use 3 definitions for COI in this paper: a broadly defined criterion, the criterion used by The International Council of Medical Journal Editors (ICMJE), and a criterion defined by the authors. RESULTS Depending on the COI criteria used, 16.6% to 32.6% of manuscripts had 1 or more author with COI. Based on ICMJE criterion, 38.7% of studies investigating drug treatments had authors with COI. We observed a strong association between those studies whose authors had COI and reported positive findings (P < .001). When controlling for sample size, study design, and country of primary authors, we observed a strong association between positive results and COI (ICMJE definition) among all treatment studies (adjusted odds ratio [OR], 2.35; 95% confidence interval [CI], 1.08 to 5.09) and drug studies alone (OR, 2.64; 95% CI, 1.09 to 6.39). CONCLUSION COI is widespread among the authors of published manuscripts and these authors are more likely to present positive findings. PMID:14748860

Analytical investigations on the Coronation Gospels manuscript

NASA Astrophysics Data System (ADS)

Aceto, Maurizio; Agostino, Angelo; Fenoglio, Gaia; Idone, Ambra; Crivello, Fabrizio; Griesser, Martina; Kirchweger, Franz; Uhlir, Katharina; Puyo, Patricia Roger

2017-01-01

The Coronation Gospels or Krönungsevangeliar is a manuscript kept in Vienna at the Kunsthistorisches Museum Wien, datable to the end of VIII century A.D. and produced at Charlemagne court. It is an example of a purple codex, i.e. its parchment is coloured in purple. It has to be considered as one of the most important medieval codices, according to its use to take oath in the coronation ceremony of kings and emperors of the Holy Roman Empire up to 1792. In order to gather information of the manufacture of the manuscript and its present conservation state, a diagnostic investigation campaign has been carried out in situ with totally non-invasive techniques. X-ray Fluorescence Spectrometry (XRF), UV-visible diffuse reflectance spectrophotometry with optical fibres (FORS), spectrofluorimetry, optical microscopy and multispectral analysis have been applied in order to identify the colourants used in the decoration of the manuscript, with the main concern to the dye used to impart the purple hue to the parchment. The information collected was useful in order to address some of the questions raised by art historians concerning its history.

[Illustrations of of alchemy vessels in a manuscript of Pseudo-Geber].

PubMed

Kurzmann, Peter

2011-01-01

Manuscript ric. 933 "Geber de investigatione perfectionis magisterii", kept in the Libreria Riccardiana in Florence, is a 13th century Latin version of the "Book of the Secret of the Secrets" ("kitab sirr al-asrar") by the Arabian alchemist al-Razi (865-925). The manuscript shows on page 25r a series of drawings of alchemistic vessels and apparatus which do not figure in the Arabian original but which are of particular interest as they date from as early as the 13th century and are numbered amongst the earliest drawings of this kind which we possess. The publication of the manuscript by Julius Ruska in 1935 shows only copied drawings with his interpretations of the legends. There was considerable interest in the publication of the original page 25r and in the course of further study it became clear that these interpretations had to be revised. These new interpretations presented in detail in this paper are justified and put into an alchemistic context. In some cases they give a new understanding and differ considerably from Ruska's versions.

On the identification of folium and orchil on illuminated manuscripts.

PubMed

Aceto, Maurizio; Calà, Elisa; Agostino, Angelo; Fenoglio, Gaia; Idone, Ambra; Porter, Cheryl; Gulmini, Monica

2017-01-15

The identification of the two purple dyes folium and orchil has rarely been reported in the analysis of painted artworks, especially when analysing illuminated manuscripts. This is not consistent with the fact that ancient literary sources suggested their use as substitutes for the more expensive Tyrian purple dye. By employing non-invasive spectroscopic techniques, the present work demonstrates that these dyes were actually widely used in the production of ancient manuscripts. By employing UV-visible diffuse reflectance spectrophotometry with optic fibres (FORS) and spectrofluorimetry, the abundant identification of both dyes on medieval manuscripts was performed by comparing the spectra recorded on ancient codices with those obtained on accurate replicas of dyed or painted parchment. Moreover, examples are also reported whereby the considered purple dyes were used in mixtures with other colourants. The overall information obtained here allowed us to define new boundaries for the time range in which orchil and folium dyes were used which is wider than previously thought, and to focus on their particular uses in the decoration of books. Copyright © 2016 Elsevier B.V. All rights reserved.

Material Processing and Design of Biodegradable Metal Matrix Composites for Biomedical Applications.

PubMed

Yang, Jingxin; Guo, Jason L; Mikos, Antonios G; He, Chunyan; Cheng, Guang

2018-06-04

In recent years, biodegradable metallic materials have played an important role in biomedical applications. However, as typical for the metal materials, their structure, general properties, preparation technology and biocompatibility are hard to change. Furthermore, biodegradable metals are susceptible to excessive degradation and subsequent disruption of their mechanical integrity; this phenomenon limits the utility of these biomaterials. Therefore, the use of degradable metals, as the base material to prepare metal matrix composite materials, it is an excellent alternative to solve the problems above described. Biodegradable metals can thus be successfully combined with other materials to form biodegradable metallic matrix composites for biomedical applications and functions. The present article describes the processing methods currently available to design biodegradable metal matrix composites for biomedical applications and provides an overview of the current existing biodegradable metal systems. At the end, the manuscript presents and discusses the challenges and future research directions for development of biodegradable metallic matrix composites for biomedical purposes.

Predictors of Manuscript Publication: A Review of Obstetrics and Gynecology Society Meeting Abstracts.

PubMed

Muffly, Tyler M; Webster, Kelsey; Conageski, Christine; Guiahi, Maryam

2016-01-01

The authors attempted to understand the manuscript publication rate and predictors of publication of abstracts presented at obstetrical and gynecologic society meetings. In 2013, the authors obtained the text of all 2005 abstracts presented at a major generalist- and fellowship-associated society meetings. In this cross-sectional study, a search was completed for publication and identified possible predictors. The authors examined 1405 abstracts; the overall full-text publication rate was 54% (755/1405 publications) and the mean (SD) time to publication was 25.6 (20.8) months. Variables associated with publication in multivariable analysis included number of abstract authors (odds ratio [OR], 1.7; confidence interval [CI], 1.0-1.2), first authorship in American Congress of Obstetricians and Gynecologists district IV (OR, 1.7; CI, 0.9-3.1), prospective design (OR, 1.7; CI, 0.9-3.1), multicenter design (OR, 2.5; CI, 1.3-4.9), and oral presentation (OR, 3.2; CI, 1.4-7.3). Abstracts from specialty meetings were more likely to have these characteristics and, thus, higher publication rates. This study can guide project development for young researchers by informing them of key study design features associated with manuscript publication.

Integration of PanDA workload management system with Titan supercomputer at OLCF

NASA Astrophysics Data System (ADS)

De, K.; Klimentov, A.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.

2015-12-01

The PanDA (Production and Distributed Analysis) workload management system (WMS) was developed to meet the scale and complexity of LHC distributed computing for the ATLAS experiment. While PanDA currently distributes jobs to more than 100,000 cores at well over 100 Grid sites, the future LHC data taking runs will require more resources than Grid computing can possibly provide. To alleviate these challenges, ATLAS is engaged in an ambitious program to expand the current computing model to include additional resources such as the opportunistic use of supercomputers. We will describe a project aimed at integration of PanDA WMS with Titan supercomputer at Oak Ridge Leadership Computing Facility (OLCF). The current approach utilizes a modified PanDA pilot framework for job submission to Titan's batch queues and local data management, with light-weight MPI wrappers to run single threaded workloads in parallel on Titan's multicore worker nodes. It also gives PanDA new capability to collect, in real time, information about unused worker nodes on Titan, which allows precise definition of the size and duration of jobs submitted to Titan according to available free resources. This capability significantly reduces PanDA job wait time while improving Titan's utilization efficiency. This implementation was tested with a variety of Monte-Carlo workloads on Titan and is being tested on several other supercomputing platforms. Notice: This manuscript has been authored, by employees of Brookhaven Science Associates, LLC under Contract No. DE-AC02-98CH10886 with the U.S. Department of Energy. The publisher by accepting the manuscript for publication acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes.

Thomas Starzl, Video Interview for His Living Legend Award at the ISBTS 2015.

PubMed

Gondolesi, G E; Mazariegos, G; Starzl, T E

2016-03-01

At the 14th International Small Bowel Transplant Symposium, (ISBTS2015) held in Buenos Aires, a session to recognize the pioneers that have dedicated their lives to make our current field possible was organized. Dr Thomas Starzl received the first Living Legend Award. A video interview was obtained at his office, edited, and later presented during the scientific meeting. More than 600 people saw Dr Starzl's interview, which captivated the audience for 40 minutes, before smiles, tears and the final applause erupted at the conclusion. We would like to share this video with all of you to inspire the current generations and the generations to come. The manuscript has the main parts of the interview, which can also be accessed at http://isbts2015.tts.org/starzl.mp4. Copyright © 2016 Elsevier Inc. All rights reserved.

Presenting Papers at ABCA Conferences: Opinions and Recommendations.

ERIC Educational Resources Information Center

Mier, Denise; Myers, Robert

1981-01-01

Offers guidelines for preparing and presenting papers at American Business Communication Association (ABCA) conferences. Topics covered include: (1) types of delivery, (2) extemporaneous speaking, and (3) manuscript speaking. (FL)

Case studies: the impact of nonanalyte components on LC-MS/MS-based bioanalysis: strategies for identifying and overcoming matrix effects.

PubMed

Li, Fumin; Ewles, Matthew; Pelzer, Mary; Brus, Theodore; Ledvina, Aaron; Gray, Nicholas; Koupaei-Abyazani, Mohammad; Blackburn, Michael

2013-10-01

Achieving sufficient selectivity in bioanalysis is critical to ensure accurate quantitation of drugs and metabolites in biological matrices. Matrix effects most classically refer to modification of ionization efficiency of an analyte in the presence of matrix components. However, nonanalyte or matrix components present in samples can adversely impact the performance of a bioanalytical method and are broadly considered as matrix effects. For the current manuscript, we expand the scope to include matrix elements that contribute to isobaric interference and measurement bias. These three categories of matrix effects are illustrated with real examples encountered. The causes, symptoms, and suggested strategies and resolutions for each form of matrix effects are discussed. Each case is presented in the format of situation/action/result to facilitate reading.

Acceptance rate and reasons for rejection of manuscripts submitted to Veterinary Radiology & Ultrasound during 2012.

PubMed

Lamb, Christopher R; Mai, Wilfried

2015-01-01

Better understanding of the reasons why manuscripts are rejected, and recognition of the most frequent manuscript flaws identified by reviewers, should help submitting authors to avoid these pitfalls. Of 219 manuscripts submitted to Veterinary Radiology & Ultrasound in 2012, none (0%) was accepted without revision, four (2%) were withdrawn by the authors, 99 (45%) were accepted after revision, and 116 (53%) were rejected. All manuscripts for which minor revision was requested, and 73/86 (85%) manuscripts for which major revision was requested, were ultimately accepted. Acceptance rate was greater for retrospective studies and for manuscripts submitted from countries in which English was the primary language. The prevalences of flaws in manuscripts were poor writing (62%), deficiencies in data (60%), logical or methodological errors (28%), content not suitable for Veterinary Radiology & Ultrasound (26%), and lack of new or useful knowledge (25%). Likelihood of manuscript rejection was greater for lack of new or useful knowledge and content not suitable than for other manuscript flaws. The lower acceptance rate for manuscripts from countries in which English was not the primary language was associated with content not suitable and not poor writing. Submitting authors are encouraged to do more to recognize and address manuscript flaws before submission, for example by internal review. Specifically, submitting authors should express clearly the potential added value of their study in the introduction section of their manuscript, describe completely their methods and results, and consult the Editor-in-Chief if they are uncertain whether their subject matter would be suitable for the journal. © 2014 American College of Veterinary Radiology.

Unravelling the ambiguous reproductive biology of Paspalum malacophyllum: a decades old story clarified

USDA-ARS?s Scientific Manuscript database

A recent a manuscript was published by our group that analyzed the reproductive biology of the grass species Paspalum malacophyllum using traditional embryological techniques combined with current cytological and molecular methods. Our findings confirmed apparent contradictions regarding the reprod...

Integration of Titan supercomputer at OLCF with ATLAS Production System

NASA Astrophysics Data System (ADS)

Barreiro Megino, F.; De, K.; Jha, S.; Klimentov, A.; Maeno, T.; Nilsson, P.; Oleynik, D.; Padolski, S.; Panitkin, S.; Wells, J.; Wenaus, T.; ATLAS Collaboration

2017-10-01

The PanDA (Production and Distributed Analysis) workload management system was developed to meet the scale and complexity of distributed computing for the ATLAS experiment. PanDA managed resources are distributed worldwide, on hundreds of computing sites, with thousands of physicists accessing hundreds of Petabytes of data and the rate of data processing already exceeds Exabyte per year. While PanDA currently uses more than 200,000 cores at well over 100 Grid sites, future LHC data taking runs will require more resources than Grid computing can possibly provide. Additional computing and storage resources are required. Therefore ATLAS is engaged in an ambitious program to expand the current computing model to include additional resources such as the opportunistic use of supercomputers. In this paper we will describe a project aimed at integration of ATLAS Production System with Titan supercomputer at Oak Ridge Leadership Computing Facility (OLCF). Current approach utilizes modified PanDA Pilot framework for job submission to Titan’s batch queues and local data management, with lightweight MPI wrappers to run single node workloads in parallel on Titan’s multi-core worker nodes. It provides for running of standard ATLAS production jobs on unused resources (backfill) on Titan. The system already allowed ATLAS to collect on Titan millions of core-hours per month, execute hundreds of thousands jobs, while simultaneously improving Titans utilization efficiency. We will discuss the details of the implementation, current experience with running the system, as well as future plans aimed at improvements in scalability and efficiency. Notice: This manuscript has been authored, by employees of Brookhaven Science Associates, LLC under Contract No. DE-AC02-98CH10886 with the U.S. Department of Energy. The publisher by accepting the manuscript for publication acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes.

Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Callis, Judy

This report summarizes our research activities. In the award period, we have made significant progress on the first aim, with new discoveries reported in one published paper (1) and in one submitted manuscript (2) currently under review. The published manuscript reports on our discovery of plant ribokinase and the metabolic pathway in which it functions; the submitted manuscript is identification and characterization of the plant fructokinase family of enzymes from expression studies, sequence comparisons, subcellular localizations and enzymatic activities of recombinant proteins. Our study of loss-of-function mutants in the fructokinase family members (2) revealed that there were no phenotypic differencesmore » observed for the five genes analyzed, so we have adopted the Crispr/Cas9 system to isolate mutants in the two genes for which there are no currently available insertion mutants, and we are generating higher order mutants (double, triples, etc) to discern the relative roles and significance for each fructokinase. These mutants will be an important resource to understand regulation of carbohydrate movement and catabolism in plants. As studies from others indicate, alteration of fructokinases results in changes in cell walls and vasculatures, which have importance relative to biofuel yield and quality. In the second aim, we have characterized the protein-protein interactions for the pkfB proteins FLN1 and FLN2 that are localized to chloroplast transcriptional complexes and have proposed a new model for how chloroplast transcription is regulated. This work has been submitted for publication, been revised and will be re-submitted in December 2016« less

Medieval Stars in Melk Abbey

NASA Astrophysics Data System (ADS)

Beck, P. G.; Zotti, G.

2012-05-01

Melk Abbey, a marvel of European high baroque architecture, is one of the most frequently visited tourist attractions in Austria, attracting 450 000 visitors each year. The monastery's museum presents selected aspects of Benedictine life in Melk since the monastery's foundation in 1089. After the church, the library is the second-most important room in a Benedictine monastery. Due to the wide scientific interests and contacts of the medieval monks, these libraries also contain manuscripts on mathematics, physics and astronomy. In 2009, the International Year of Astronomy (IYA2009), the annual library exhibition was fully dedicated to astronomical manuscripts and early prints from the past 1000 years. Following earlier research work on astronomical manuscripts in Melk's library, we were invited to organise the exhibition. In addition, we also presented a lecture series and provided more background in an accompanying book. Because of positive feedback from the visitors, the exhibition was extended until March 2011. In the two years of its duration, the exhibition was seen by more than 900 000 visitors. In this article, we describe the background to the scientific project, how the exhibition was organised and lessons learned from this project.

Major Changes in AGU Publication Fees

NASA Astrophysics Data System (ADS)

Cook, Bill

2010-12-01

Effective with any manuscript submitted after 31 December 2010, AGU is eliminating color charges in all formats. At the same time that we eliminate color charges, we are simplifying publication fees. Articles published in Journal of Geophysical Research; Geochemistry, Geophysics, Geosystems; and Radio Science will each have a flat fee of $1000, and Geophysical Research Letters (GRL) articles will each have a flat fee of $500. These prices represent a small drop from the average cost currently paid by authors. We will retain the excess page charges for full articles longer than 13 pages (including Water Resources Research) and 4 pages for letters, comments, and replies. This simplification means we can streamline the “calculator” authors must use when submitting manuscripts to AGU.

Toward a Well-Utilized Partnership

ERIC Educational Resources Information Center

Coleman, Hardin L. K.

2004-01-01

Romano and Kachgal have done an outstanding job of describing the historical, current, and potential relationship between counseling psychology and school counseling. Their summary of these issues should be required reading for all faculty who participate, directly or indirectly, in a school counseling program; all reviewers of manuscripts for…

Molecular and Microscopical Investigation of the Microflora Inhabiting a Deteriorated Italian Manuscript Dated from the Thirteenth Century

PubMed Central

Michaelsen, Astrid; Piñar, Guadalupe

2010-01-01

This case study shows the application of nontraditional diagnostic methods to investigate the microbial consortia inhabiting an ancient manuscript. The manuscript was suspected to be biologically deteriorated and SEM observations showed the presence of fungal spores attached to fibers, but classic culturing methods did not succeed in isolating microbial contaminants. Therefore, molecular methods, including PCR, denaturing gradient gel electrophoresis (DGGE), and clone libraries, were used as a sensitive alternative to conventional cultivation techniques. DGGE fingerprints revealed a high biodiversity of both bacteria and fungi inhabiting the manuscript. DNA sequence analysis confirmed the existence of fungi and bacteria in manuscript samples. A number of fungal clones identified on the manuscript showed similarity to fungal species inhabiting dry or saline environments, suggesting that the manuscript environment selects for osmophilic or xerophilic fungal species. Most of the bacterial sequences retrieved from the manuscript belong to phylotypes with cellulolytic activities. PMID:20449583

2014 Global Conference on Polymer and Composite Materials (PCM 2014)

NASA Astrophysics Data System (ADS)

2014-08-01

The 2014 Global Conference on Polymer and Composite Materials (PCM 2014) sponsored by Ningbo Adhesives and Products Industry Association, Shanghai Bonding Technology Association, Zhejiang Bonding Technology Association, Wuhan Bonding Technology Association, Hebei Bonding and Coatings Association and Polyurethane Industry Association was held from May 27 to May 29 2014 in Ningbo, China. The technical program consisted of 8 international keynote speakers, oral presentations, and a poster session. The conference also included an industrial exhibition where more than 50 companies displayed in their booths their most recent advanced products and services. The present issue of IOP Conference Series: Materials Science and Engineering (MSE) records the proceedings of PCM 2014 and contains 37 specially selected manuscripts submitted to PCM2014 conference. The electronic submission and handling of manuscripts via the conference website, including the selection of reviewers and evaluation of manuscripts, were identical to the procedures applied to manuscripts submitted as regular contributions for publication. The organization of this conference and the preparation of proceedings volumes would have been impossible without the tremendous efforts and dedication of many individuals, especially from Ms. Yin Pan, who oversaw the organization of the conference and the program; and a large team of reviewers with their timely submission of quality reports. We express our sincere thanks to all authors and presenters for their contributions. We also thank very much our sponsors for their generous support. The 2015 Global Conference on Polymer and Composite Materials (PCM2015) will be held in Beijing, China on May 16-18, 2015. Beijing, the capital of the People's Republic of China and one of the most populous cities in the world, will welcome to all participants for a renewed and vibrant conference. Prof. Dr. Esteban Broitman Linköping University, Sweden Editor in Chief — PCM2014

Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI).

PubMed

Bialer, Meir; Johannessen, Svein I; Levy, René H; Perucca, Emilio; Tomson, Torbjörn; White, H Steve

2013-01-01

The Eleventh Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT XI, took place in Eilat, Israel from the 6th to 10th of May 2012. About 100 basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included "Indications overlapping with epilepsy" and "Securing the successful development of an investigational antiepileptic drug in the current environment". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 1994. Like the EILAT X report, the current manuscript focuses only on the preclinical and clinical pharmacology of AEDs that are currently in development. These include brivaracetam, 2-deoxy-glucose, ganaxolone, ICA-105665, imepitoin, NAX 801-2, perampanel and other AMPA receptor antagonists, tonabersat, valnoctamide and its homologue sec-propylbutylacetamide (SPD), VX-765 and YK3089. Since the previous Eilat conference, retigabine (ezogabine) has been marketed and four newer AEDs in development (NAX 810-2, SPD, tonabersat and VX-765) are included in this manuscript. Copyright © 2012 Elsevier B.V. All rights reserved.

[Writing and publication of a medical article].

PubMed

Salmi, L R

1999-11-01

To advance in their strategies to manage patients, clinicians need new research results. To be accessible, medical research must be published. Writing and publishing medical articles should respect principles that are described in this article. Good writing is based on a logical organization and the application of scientific style. Organization according to the IMRD structure (Introduction, Methods, Results, Discussion) allows one to present the reasons for and objectives of the study (Introduction), details on whatever has been done to answer the question (Methods), data on the actual study population and answers to the main question (Results), and a critical appraisal of these results, given the limits of the study and current knowledge (Discussion). The main elements of scientific style are precision, clarity, fluidity and concision. Finally, submitting a paper to a scientific journal implies presenting the work in a covering letter and respecting rules for formatting a manuscript (order of presentation, typography, etc.).

The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting.

PubMed

Arciniegas, David B; Lauterbach, Edward C; Anderson, Karen E; Chow, Tiffany W; Flashman, Laura A; Hurley, Robin A; Kaufer, Daniel I; McAllister, Thomas W; Reeve, Alison; Schiffer, Randolph B; Silver, Jonathan M

2005-05-01

This monograph summarizes the proceedings of a roundtable meeting convened to discuss pseudobulbar affect (PBA). Two didactic lectures were presented followed by a moderated discussion among 11 participants. Post-meeting manuscript development synthesized didactic- and discussion-based content ad incorporated additional material from the neuroscience literature. A conceptual framework with which to distinguish between disorders of mood and affect is presented first, and disorders of affect regulation are then reviewed briefly. A detailed description of the most common of these disorders, PBA, is the focus of the remainder of the monograph. The prevalence, putative neuranatomic and neurochemical bases of PBA are reviewed, and current and emerging methods of evaluation and treatment of persons with PBA are discussed. The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition.

The Discrete Emotions Questionnaire: A New Tool for Measuring State Self-Reported Emotions.

PubMed

Harmon-Jones, Cindy; Bastian, Brock; Harmon-Jones, Eddie

2016-01-01

Several discrete emotions have broad theoretical and empirical importance, as shown by converging evidence from diverse areas of psychology, including facial displays, developmental behaviors, and neuroscience. However, the measurement of these states has not progressed along with theory, such that when researchers measure subjectively experienced emotions, they commonly rely on scales assessing broad dimensions of affect (positivity and negativity), rather than discrete emotions. The current manuscript presents four studies that validate a new instrument, the Discrete Emotions Questionnaire (DEQ), that is sensitive to eight distinct state emotions: anger, disgust, fear, anxiety, sadness, happiness, relaxation, and desire. Emotion theory supporting the importance of distinguishing these specific emotions is reviewed.

[SEMERGEN positioning for the treatment of alcohol disorders in primary care].

PubMed

Arbesú, José Ángel; Gual, Antoni; Casquero, Rafael; Bobes, Julio; Ortega, Patricia

2015-12-01

The present manuscript is based on the recommendations of a panel of health care professionals, including several experts in primary health care, psychiatry and addictions. The participants are recognized specialists in the treatment of alcohol use disorder. The panel met in Barcelona on 2015 April 22 with the aims of evaluating the current management of alcohol use disorder in primary health care and developing a strategy to address this problem, basing on the evidence and the recommendations of the scientific societies and national and international organizations. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Medicina Rural y Generalista (SEMERGEN). All rights reserved.

The Discrete Emotions Questionnaire: A New Tool for Measuring State Self-Reported Emotions

PubMed Central

Harmon-Jones, Cindy; Bastian, Brock

2016-01-01

Several discrete emotions have broad theoretical and empirical importance, as shown by converging evidence from diverse areas of psychology, including facial displays, developmental behaviors, and neuroscience. However, the measurement of these states has not progressed along with theory, such that when researchers measure subjectively experienced emotions, they commonly rely on scales assessing broad dimensions of affect (positivity and negativity), rather than discrete emotions. The current manuscript presents four studies that validate a new instrument, the Discrete Emotions Questionnaire (DEQ), that is sensitive to eight distinct state emotions: anger, disgust, fear, anxiety, sadness, happiness, relaxation, and desire. Emotion theory supporting the importance of distinguishing these specific emotions is reviewed. PMID:27500829

Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting.

PubMed

Street, Maria Elisabeth; Angelini, Sabrina; Bernasconi, Sergio; Burgio, Ernesto; Cassio, Alessandra; Catellani, Cecilia; Cirillo, Francesca; Deodati, Annalisa; Fabbrizi, Enrica; Fanos, Vassilios; Gargano, Giancarlo; Grossi, Enzo; Iughetti, Lorenzo; Lazzeroni, Pietro; Mantovani, Alberto; Migliore, Lucia; Palanza, Paola; Panzica, Giancarlo; Papini, Anna Maria; Parmigiani, Stefano; Predieri, Barbara; Sartori, Chiara; Tridenti, Gabriele; Amarri, Sergio

2018-06-02

Wildlife has often presented and suggested the effects of endocrine disrupting chemicals (EDCs). Animal studies have given us an important opportunity to understand the mechanisms of action of many chemicals on the endocrine system and on neurodevelopment and behaviour, and to evaluate the effects of doses, time and duration of exposure. Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. This manuscript reviews the reports of a multidisciplinary national meeting on this topic.

Standardized definitions and clinical endpoints in carotid artery and supra-aortic trunk revascularization trials.

PubMed

Nedeltchev, Krassen; Pattynama, Peter M; Biaminoo, Giancarlo; Diehm, Nicolas; Jaff, Michael R; Hopkins, L Nelson; Ramee, Stephen; van Sambeek, Marc; Talen, Aly; Vermassen, Frank; Cremonesi, Alberto

2010-09-01

Endovascular therapy has emerged as a promising alternative to open surgery for stroke prevention in patients with obstructive disease of the supra-aortic arteries. Although most previous studies have used similar safety and efficacy endpoints, differences in definitions, timing of assessments, and standards of reporting have hampered direct comparisons across various trials. The DEFINE group, an informal collaboration of multidisciplinary physicians, involved in the therapy of patients with obstructive disease of the supra-aortic arteries in Europe and the United States reviewed the current literature and, after extensive correspondence and meetings, proposed the definitions outlined in the present manuscript. Three meetings including all authors of the manuscript, along with representatives of the United States Food and Drug Administration (FDA) and commercial device manufacturers were held in Barcelona, Spain, in May 2008, in Munich, Germany, in July 2008, and in New York in November 2008. The proposed definitions encompass baseline clinical and anatomic characteristics, clinical and radiologic outcomes, complications, standards of reporting, and timing of assessment. Considering the broad consensus between the multidisciplinary scientific members and the regulatory authorities, the proposed definitions are expected to find adoption in future clinical investigations. These definitions can be applied to both endovascular and open surgery trials and will allow reliable comparisons between these two revascularization methods.

Defining, treating and preventing hospital acquired pneumonia: European perspective.

PubMed

Torres, Antoni; Ewig, Santiago; Lode, Harmut; Carlet, Jean

2009-01-01

Many controversies still remain in the management of hospital acquired pneumonia (HAP), and ventilation-acquired pneumonia (VAP), Three European Societies, European Respiratory Society (ERS), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and European Society of Intensive Care Medicine (ESICM), were interested in producing a document on HAP and VAP with European perspective. The scientific committees from each Society designated one chairman; Antoni Torres (ERS), Harmut Lode (ESCMID) and Jean Carlet (ESICM). The chairmen of this Task Force suggested names from each Society to be a member of the panel. They also choose controversial topics on the field and others that were not covered by the last IDSA/ATS guidelines. Each topic was assigned to a pair of members to be reviewed and written. Finally, the panel defined 20 consensual points that were circulated several times among the members of the panel until total agreement was reached. A combination of evidences and clinical-based medicine was used to reach these consensus. This manuscript reviews in depth several controversial or new topics in HAP and VAP. In addition 20 consensual points are presented. This manuscript may be useful for the development of future guidelines and to stimulate clinical research by lying out what is currently accepted and what is unknown or controversial.

Quantum Control of Spins in Diamond for Nanoscale Magnetic Sensing and Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dutt, Gurudev

Our research activities during the grant period focused on the challenges of highly accurate and precise magnetometry and magnetic imaging using quantum spins inside diamond. Our work has resulted in 6 papers published in peer-reviewed journals, with two more currently under consideration by referees. We showed that through the use of novel phase estimation algorithms inspired by quantum information science we can carry out accurate and high dynamic range DC magnetometry as well as lock-in detection of oscillating (AC) magnetic fields. We investigated the geometric phase as a route to higher precision quantum information and magnetic sensing applications, and probedmore » the experimental limits to the fidelity of such geometric phase gates. We also demonstrated that there is a spin dependent signal in the charge state flipping of the NV defect center in diamond, which could potentialy be useful for higher fidelity spin readout at room temperature. Some of these projects have now led to further investigation in our lab on multi-photon spectroscopy (manuscript in preparation), and plasmonic guiding of light in metal nanowires (manuscript available on arxiv). In addition, several invited talks were given by the PI, and conference presentations were given by the graduate students and postdocs.« less

LAKE HERRING (COREGONUS ARTEDI) AND RAINBOW SMELT (OSMERUS MORDAX) DIETS IN LAKE SUPERIOR

EPA Science Inventory

This manuscript reports on the diets of lake herring and rainbow smelt, currently the two dominant forage fish species (fish that are food for game fishes) in western Lake Superior. Despite the pelagic nature of both these species, they have substantially different diets and henc...

Consultation in Bullying Prevention: An Elementary School Case Study

ERIC Educational Resources Information Center

Morrow, Michael T.; Hooker, Steven D.; Cate, Rebecca Lynne

2015-01-01

This manuscript outlines a consultation with a public elementary school that was aimed at assessing and strengthening the school's antibullying programs. We gathered consultation data through interviews and observations and also reviewed existing program evaluation data. We evaluated these data in light of current research on bullying prevention…

Plagiarism within Extension: Origin and Current Effects

ERIC Educational Resources Information Center

Rollins, Dora

2011-01-01

Extension publication editors from around the United States are finding cases of plagiarism within manuscripts that Extension educators submit as new public education materials. When editors confront such educators with the problem, some don't understand it as such, rationalizing that reproducing published information for a new purpose qualifies…

Researching Western History: Denver Public Library Is the Place to Go.

ERIC Educational Resources Information Center

Bond, Robert

1989-01-01

Reviews the development of the Western History Department of the Denver Public Library and describes the current collection, which includes military records, manuscripts and personal papers, newspapers, photographs, and paintings. The discussion covers library policies that balance public access and preservation, financial support for the…

Sharing Your Practice Expertise: Writing Clinical Manuscripts for Publication.

PubMed

McGrath, Jacqueline M; Brandon, Debra

2015-08-01

Please do not be afraid of the writing process; we are here to help you through this journey. If you need mentorship through the process, consider looking to an expert or mentor on your unit or at a nearby university. If you do not find the mentorship you are seeking nearby, please let us know. We will put you in contact with 1 of our editorial board members to help guide you through the writing process. We want you to be successful so please have an outline of your idea and the type of manuscript you are planning to write developed. When you contact us, please share your questions openly—there are no “dumb” questions. Please refer often to our author guidelines during the writing process. Details for how best to submit a manuscript for the Clinical Issues in Neonatal Care section are outlined within the author guidelines. Finally, it is important to remember that ANC is a 4-color journal, so please submit full-color tables, graphs, and pictures to enhance the readability of your manuscript. During the editorial process we will do everything we can to facilitate and enhance your work. We will make recommendations that we believe will increase its scholarly application to improving neonatal care and outcomes. Revisions are often requested. After peer review, the section editor and coeditors will review the manuscript well in advance of the production deadline and provide additional feedback as needed. The end goal is excellent presentation of materials for our readers. If you are a reviewer for ANC , the next time you are asked to review a Clinical Issues in Neonatal Care manuscript, please consider the quality of the manuscript in relationship to guiding clinical care at the bedside and make recommendations to improve the manuscript so that staff nurses will best relate to the content. Do not be afraid to make recommendations about missing content or suggestions about ways to enhance the content and make it easier for clinicians to understand. Help us and the authors to increase their creativity and enhance their work. We want ANC to be the best clinical and research journal in neonatal care with articles of all styles that help us to enhance our caregiving and patient outcomes!

Making the First Cut: An Analysis of Academic Medicine Editors' Reasons for Not Sending Manuscripts Out for External Peer Review.

PubMed

Meyer, Holly S; Durning, Steven J; Sklar, David P; Maggio, Lauren A

2018-03-01

Manuscripts submitted to Academic Medicine (AM) undergo an internal editor review to determine whether they will be sent for external peer review. Increasingly, manuscripts are rejected at this early stage. This study seeks to inform scholars about common reasons for internal editor review rejections, increase transparency of the process, and provide suggestions for improving submissions. A mixed-methods approach was used to retrospectively analyze editors' free-text comments. Descriptive content analysis was performed of editors' comments for 369 manuscripts submitted between December 2014 and December 2015, and rejected prior to external peer review from AM. Comments were analyzed, categorized, and counted for explicit reasons for rejection. Nine categories of rejection reasons were identified: ineffective study question and/or design (338; 92%); suboptimal data collection process (180; 49%); weak discussion and/or conclusions (139; 37%); unimportant or irrelevant topic to the journal's mission (137; 37%); weak data analysis and/or presentation of results (120; 33%); text difficult to follow, to understand (89; 24%); inadequate or incomplete introduction (67; 18%); other publishing considerations (42; 11%); and issues with scientific conduct (20; 5%). Manuscripts had, on average, three or more reasons for rejection. Findings suggest that clear identification of a research question that is addressed by a well-designed study methodology on a topic aligned with the mission of the journal would address many of the problems that lead to rejection through the internal review process. The findings also align with research on external peer review.

[Health implications of the establishment and spread of Aedes albopictus in Spain].

PubMed

Bueno Marí, Rubén; Jiménez Peydró, Ricardo

2012-01-01

The spread of Aedes albopictus by Eastern Spain has been constant since its first finding in 2004. Currently the species has been collected in the coastal provinces of Girona, Barcelona, Tarragona, Castellón, Alicante and Murcia. The high synanthropism of the species, together with its anthropophilic behaviour and vectorial capacity to transmit several arboviruses, have led to the return of active transmission cycles of common diseases in the past such as Dengue virus and even the appearance of new tropical viruses as Chikungunya in southern Europe. This manuscript discusses the public health implications of the expected expansion of Ae. albopictus for much of the Iberian Peninsula, in the context of current climatic and sociodemographic situation. Moreover, several issues related with the control of the species in urban and suburban environments are exposed. Finally the preliminary data about other invasive aedines recently collected in the European continent are presented.

Ginkgo biloba Extract in Vascular Protection: Molecular Mechanisms and Clinical Applications.

PubMed

Tian, Jinfan; Liu, Yue; Chen, Keji

2017-01-01

Leaves of Ginkgo biloba, a "living fossil," have been used as traditional herbal medicine for hundreds of years in China. Currently, its application in vascular protection is garnering much attention. In this manuscript, preclinical studies were reviewed to discuss various mechanisms underlying the vascular protection by Ginkgo biloba extract (GBE). Additionally, we reviewed clinical studies to present the application of GBE in the ischaemic disease. GBE, a commonly used dietary supplement, has been shown to act as an antioxidant and freeradical scavenger, a membrane stabilizer, an inhibitor of the platelet-activating factor, a vasodilator, and a regulator of metabolism. Currently, there exist a growing number of clinical studies about GBE in the application of cardiovascular disease, peripheral vascular disease (PVD) and diabetic vascular complications. GBE, a promising therapeutic agent for cardiovascular and ischaemic diseases, exerts vascular- protection function by a comprehensive mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

SharedCanvas: A Collaborative Model for Medieval Manuscript Layout Dissemination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanderson, Robert D.; Albritton, Benjamin; Schwemmer, Rafael

2011-01-01

In this paper we present a model based on the principles of Linked Data that can be used to describe the interrelationships of images, texts and other resources to facilitate the interoperability of repositories of medieval manuscripts or other culturally important handwritten documents. The model is designed from a set of requirements derived from the real world use cases of some of the largest digitized medieval content holders, and instantiations of the model are intended as the input to collection-independent page turning and scholarly presentation interfaces. A canvas painting paradigm, such as in PDF and SVG, was selected based onmore » the lack of a one to one correlation between image and page, and to fulfill complex requirements such as when the full text of a page is known, but only fragments of the physical object remain. The model is implemented using technologies such as OAI-ORE Aggregations and OAC Annotations, as the fundamental building blocks of emerging Linked Digital Libraries. The model and implementation are evaluated through prototypes of both content providing and consuming applications. Although the system was designed from requirements drawn from the medieval manuscript domain, it is applicable to any layout-oriented presentation of images of text.« less

Statistical Data Editing in Scientific Articles.

PubMed

Habibzadeh, Farrokh

2017-07-01

Scientific journals are important scholarly forums for sharing research findings. Editors have important roles in safeguarding standards of scientific publication and should be familiar with correct presentation of results, among other core competencies. Editors do not have access to the raw data and should thus rely on clues in the submitted manuscripts. To identify probable errors, they should look for inconsistencies in presented results. Common statistical problems that can be picked up by a knowledgeable manuscript editor are discussed in this article. Manuscripts should contain a detailed section on statistical analyses of the data. Numbers should be reported with appropriate precisions. Standard error of the mean (SEM) should not be reported as an index of data dispersion. Mean (standard deviation [SD]) and median (interquartile range [IQR]) should be used for description of normally and non-normally distributed data, respectively. If possible, it is better to report 95% confidence interval (CI) for statistics, at least for main outcome variables. And, P values should be presented, and interpreted with caution, if there is a hypothesis. To advance knowledge and skills of their members, associations of journal editors are better to develop training courses on basic statistics and research methodology for non-experts. This would in turn improve research reporting and safeguard the body of scientific evidence. © 2017 The Korean Academy of Medical Sciences.

Prevalence of Research Publication Misrepresentation Among Urology Residency Applicants and Its Effect on Match Success.

PubMed

Pak, Jamie S; Pagano, Matthew J; Cooper, Kimberly L; McKiernan, James M; Badalato, Gina M

2017-01-01

To report the prevalence of research misrepresentation among urology residency applicants and assess its effect on match success. All applications to the Columbia University urology residency program for the 2014-2015 match cycle were reviewed. "In-press," "accepted," and "submitted" manuscripts were verified using PubMed, Google Scholar, and journal websites. Misrepresentation for "in-press" and "accepted" manuscripts was defined as: (1) nonexistent manuscript, (2) nonauthorship of existent manuscript, (3) self-promotion to a higher author rank, and/or (4) existent manuscript in a nonpeer-reviewed publication. Logistic regression was performed to identify associated factors of misrepresentation and of match success. Of 257 applicants, 204 (79.4%) reported 1098 total manuscripts and 142 (55.3%) reported 371 unpublished manuscripts. About 5% (13 of 257) of applicants misrepresented 1 or more publications: 10 listed nonexistent manuscripts, 1 listed a publication for which he/she was listed a lower author rank than reported, 1 listed an accepted manuscript in a nonpeer-reviewed publication and for which he/she was not listed as an author, and 1 listed 4 in-press manuscripts in a nonpeer-reviewed publication. Only 55.8% (139 of 249) of "submitted" manuscripts were published within 12 months, with 41% (51 of 139) published in a journal of a lower impact factor than the reported journal of submission. Higher number of unpublished manuscripts was associated with misrepresentation. Higher Step 1 score, number of away sub-internships, and publication ratio were associated with match success. Research misrepresentation is a persistent issue in urology residency applications. However, misrepresentation in this cohort did not confer a significant advantage in match success. Published by Elsevier Inc.

External beam pixe programs at the University of California, Davis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eldred, R.A.

A PIXE system in which large or delicate samples are excited by a low-current external proton beam is described. This system has been used to analyze historical printed books and manuscripts, as well as a large variety of archeological artifacts. The steps used to protect the sample from unnecessary beam current are examined. A recent thorough study of the first volume of the Gutenberg 42-line Bible is described in some detail.

Scanning Angle Raman spectroscopy in polymer thin film characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Vy H.T.

The focus of this thesis is the application of Raman spectroscopy for the characterization of thin polymer films. Chapter 1 provides background information and motivation, including the fundamentals of Raman spectroscopy for chemical analysis, scanning angle Raman scattering and scanning angle Raman scattering for applications in thin polymer film characterization. Chapter 2 represents a published manuscript that focuses on the application of scanning angle Raman spectroscopy for the analysis of submicron thin films with a description of methodology for measuring the film thickness and location of an interface between two polymer layers. Chapter 3 provides an outlook and future directionsmore » for the work outlined in this thesis. Appendix A, contains a published manuscript that outlines the use of Raman spectroscopy to aid in the synthesis of heterogeneous catalytic systems. Appendix B and C contain published manuscripts that set a foundation for the work presented in Chapter 2.« less

Unsupervised categorization method of graphemes on handwritten manuscripts: application to style recognition

NASA Astrophysics Data System (ADS)

Daher, H.; Gaceb, D.; Eglin, V.; Bres, S.; Vincent, N.

2012-01-01

We present in this paper a feature selection and weighting method for medieval handwriting images that relies on codebooks of shapes of small strokes of characters (graphemes that are issued from the decomposition of manuscripts). These codebooks are important to simplify the automation of the analysis, the manuscripts transcription and the recognition of styles or writers. Our approach provides a precise features weighting by genetic algorithms and a highperformance methodology for the categorization of the shapes of graphemes by using graph coloring into codebooks which are applied in turn on CBIR (Content Based Image Retrieval) in a mixed handwriting database containing different pages from different writers, periods of the history and quality. We show how the coupling of these two mechanisms 'features weighting - graphemes classification' can offer a better separation of the forms to be categorized by exploiting their grapho-morphological, their density and their significant orientations particularities.

Fate of Manuscripts Rejected From the Red Journal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holliday, Emma B., E-mail: emmaholliday@gmail.com; Yang, George; Jagsi, Reshma

Purpose: To evaluate characteristics associated with higher rates of acceptance for original manuscripts submitted for publication to the International Journal of Radiation Oncology • Biology • Physics (IJROBP) and describe the fate of rejected manuscripts. Methods and Materials: Manuscripts submitted to the IJROBP from May 1, 2010, to August 31, 2010, and May 1, 2012, to August 31, 2012, were evaluated for author demographics and acceptance status. A PubMed search was performed for each IJROBP-rejected manuscript to ascertain whether the manuscript was ultimately published elsewhere. The Impact Factor of the accepting journal and the number of citations of the publishedmore » manuscript were also collected. Results: Of the 500 included manuscripts, 172 (34.4%) were accepted and 328 (65.6%) were rejected. There was no significant difference in acceptance rates according to gender or degree of the submitting author, but there were significant differences seen based on the submitting author's country, rank, and h-index. On multivariate analysis, earlier year submitted (P<.0001) and higher author h-index (P=.006) remained significantly associated with acceptance into the IJROBP. Two hundred thirty-five IJROBP-rejected manuscripts (71.7%) were ultimately published in a PubMed-listed journal as of July 2014. There were no significant differences in any submitting author characteristics. Journals accepting IJROBP-rejected manuscripts had a lower median [interquartile range] 2013 impact factor compared with the IJROBP (2.45 [1.53-3.71] vs 4.176). The IJROBP-rejected manuscripts ultimately published elsewhere had a lower median [interquartile range] number of citations (1 [0-4] vs 6 [2-11]; P<.001), which persisted on multivariate analysis. Conclusions: The acceptance rate for manuscripts submitted to the IJROBP is approximately one-third, and approximately 70% of rejected manuscripts are ultimately published in other PubMed-listed journals, but these ultimate-destination journals usually have a lower impact factor, leading to fewer citations and overall visibility.« less

Sambot II: A self-assembly modular swarm robot

NASA Astrophysics Data System (ADS)

Zhang, Yuchao; Wei, Hongxing; Yang, Bo; Jiang, Cancan

2018-04-01

The new generation of self-assembly modular swarm robot Sambot II, based on the original generation of self-assembly modular swarm robot Sambot, adopting laser and camera module for information collecting, is introduced in this manuscript. The visual control algorithm of Sambot II is detailed and feasibility of the algorithm is verified by the laser and camera experiments. At the end of this manuscript, autonomous docking experiments of two Sambot II robots are presented. The results of experiments are showed and analyzed to verify the feasibility of whole scheme of Sambot II.

New trends and applications in carboxylation for isotope chemistry.

PubMed

Bragg, Ryan A; Sardana, Malvika; Artelsmair, Markus; Elmore, Charles S

2018-05-08

Carboxylations are an important method for the incorporation of isotopically labeled 14 CO 2 into molecules. This manuscript will review labeled carboxylations since 2010 and will present a perspective on the potential of recent unlabeled methodology for labeled carboxylations. The perspective portion of the manuscript is broken into 3 major sections based on product type, arylcarboxylic acids, benzylcarboxylic acids, and alkyl carboxylic acids, and each of those sections is further subdivided by substrate. © 2018 AstraZeneca. Journal of Labelled Compounds and Radiopharmaceuticals Published by John Wiley & Sons, Ltd.

A Metadata description of the data in "A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human."

PubMed Central

2011-01-01

Background Metabolomics is a rapidly developing functional genomic tool that has a wide range of applications in diverse fields in biology and medicine. However, unlike transcriptomics and proteomics there is currently no central repository for the depositing of data despite efforts by the Metabolomics Standard Initiative (MSI) to develop a standardised description of a metabolomic experiment. Findings In this manuscript we describe how the MSI description has been applied to a published dataset involving the identification of cross-species metabolic biomarkers associated with type II diabetes. The study describes sample collection of urine from mice, rats and human volunteers, and the subsequent acquisition of data by high resolution 1H NMR spectroscopy. The metadata is described to demonstrate how the MSI descriptions could be applied in a manuscript and the spectra have also been made available for the mouse and rat studies to allow others to process the data. Conclusions The intention of this manuscript is to stimulate discussion as to whether the MSI description is sufficient to describe the metadata associated with metabolomic experiments and encourage others to make their data available to other researchers. PMID:21801423

A suggested outline for writing curriculum development journal articles: the IDCRD format.

PubMed

Reznich, C B; Anderson, W A

2001-01-01

During the past decade, medical school and residency faculty have been active in developing and revising curricula for medical education programs. Many of these curriculum development efforts ultimately are published in peer-reviewed professional journals as articles or abstracts. Unlike research publications, no uniform format currently exists for reporting curriculum development efforts in the peer-reviewed literature. A suggested format for organizing curriculum development manuscripts consists of the introduction, development, curriculum, results, and discussion (IDCRD). Detailed descriptions of each section are discussed herein. The IDCRD manuscript outline is intended to provide useful guidance to medical educators in publishing their curriculum development efforts. Journal editors are encouraged to recognize the importance of providing uniform descriptions of curricula so that readers can benefit from the experience of others and replicate successful curriculum efforts.

Do patients with symptoms and signs of lower urinary tract dysfunction need a urodynamic diagnosis? ICI-RS 2013.

PubMed

Rosier, Peter F W M; Giarenis, Ilias; Valentini, Francoise A; Wein, Alan; Cardozo, Linda

2014-06-01

The ICI-RS Think Tank discussed the diagnostic process for patients who present with symptoms and signs of lower urinary tract (LUT) dysfunction. This manuscript reflects the Think Tank's summary and opinion. An overview of the existing evidence and consensus regarding urodynamic testing was presented and discussed in relation to contemporary treatment strategies. Evidence of the validity of the diagnostic process in relation to the contemporary management paradigm is incomplete, scattered, and sometimes conflicting and therefore a process redesign may be necessary. The Think Tanks' suggestion, contained in this manuscript, is that the symptoms and signs that the patients present can be more precisely delineated as syndromes. The overactive bladder syndrome (OAB-S); the stress urinary incontinence syndrome (SUI-S); the urinary incontinence syndrome (UI-S); the voiding dysfunction syndrome (VD-S); and or the neurogenic LUT dysfunction syndrome (NLUTD-S) may become evidence based starting point for initial management. Consistent addition of the word syndrome, if adequately defined, acknowledges the uncertainty, but will improve outcome and will improve selection of patients that need further (invasive) diagnosis before management. The ICS-RS Think Tank has summarized the level of evidence for UDS and discussed the evidence in association with the currently changing management paradigm. The ICI-RS Think Tank recommends that the diagnostic process for patients with LUTD can be redesigned. Carefully delineated and evidence based LUTD syndromes may better indicate, personalize and improve the outcome of initial management, and may also contribute to improved and rational selection of patients for invasive UDS. Neurourol. Urodynam. 33:581-586, 2014. © 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc.

Self-Reporting MBA Key Experience Assessment: Evidence from Lincoln University

ERIC Educational Resources Information Center

Tailab, Mohamed; Guerra, Michael

2017-01-01

This paper empirically provides an innovative way of thinking about the MBA program at Lincoln University (hereafter LU) by giving students an opportunity to rate their work experience based on how they currently see themselves. This manuscript develops the instrument prepared by McMillan & Hearn (2004) by creating a questionnaire including 21…

The Selective Cue Integration Framework: A Theory of Postidentification Witness Confidence Assessment

ERIC Educational Resources Information Center

Charman, Steve D.; Carlucci, Marianna; Vallano, Jon; Gregory, Amy Hyman

2010-01-01

The current manuscript proposes a theory of how witnesses assess their confidence following a lineup identification, called the selective cue integration framework (SCIF). Drawing from past research on the postidentification feedback effect, the SCIF details a three-stage process of confidence assessment that is based largely on a…

Obstacles to the Access, Use and Transfer of Information from Archives: A RAMP Study.

ERIC Educational Resources Information Center

Duchein, Michel

This publication reviews means of access to information contained in the public archives (current administrative documents and archival records) and private archives (manuscripts of personal or family origin) of many countries and makes recommendations for improving access to archival information. Sections describe: (1) the origin and development…

So you want to get your manuscript published. Five points to remember!

USDA-ARS?s Scientific Manuscript database

The number of submissions to peer-reviewed journals is increasing, and so are rejection rates. Currently, more than 65 percent of the research reports submitted to AOCS journals are rejected for various reasons. Your next submission will have a better chance of being accepted if you understand the ...

The HGF/c-MET Axis as a Critical Driver of Resistance to Androgen Suppression in Metastatic Castrate-Resistant Prostate Cancer

DTIC Science & Technology

2016-10-01

c-MET axis in metastatic castration-resistant prostate cancer. During the current funding period, we have confirmed an inverse relationship between...resistant prostate cancer. Neoplasia 18:1-9, 2016. PMCID: 26806347. In this manuscript, we provided mechanistic evidence establishing the inverse

Prevalence of plagiarism in recent submissions to the Croatian Medical Journal.

PubMed

Baždarić, Ksenija; Bilić-Zulle, Lidija; Brumini, Gordana; Petrovečki, Mladen

2012-06-01

To assess the prevalence of plagiarism in manuscripts submitted for publication in the Croatian Medical Journal (CMJ). All manuscripts submitted in 2009-2010 were analyzed using plagiarism detection software: eTBLAST, CrossCheck, and WCopyfind. Plagiarism was suspected in manuscripts with more than 10% of the text derived from other sources. These manuscripts were checked against the Déjà vu database and manually verified by investigators. Of 754 submitted manuscripts, 105 (14%) were identified by the software as suspicious of plagiarism. Manual verification confirmed that 85 (11%) manuscripts were plagiarized: 63 (8%) were true plagiarism and 22 (3%) were self-plagiarism. Plagiarized manuscripts were mostly submitted from China (21%), Croatia (14%), and Turkey (19%). There was no significant difference in the text similarity rate between plagiarized and self-plagiarized manuscripts (25% [95% CI 22-27%] vs. 28% [95% CI 20-33%]; U = 645.50; P = 0.634). Differences in text similarity rate were found between various sections of self-plagiarized manuscripts (H = 12.65, P = 0.013). The plagiarism rate in the Materials and Methods (61% (95% CI 41-68%) was higher than in the Results (23% [95% CI 17-36%], U = 33.50; P = 0.009) or Discussion (25.5 [95% CI 15-35%]; U = 57.50; P < 0.001) sections. Three authors were identified in the Déjà vu database. Plagiarism detection software combined with manual verification may be used to detect plagiarized manuscripts and prevent their publication. The prevalence of plagiarized manuscripts submitted to the CMJ, a journal dedicated to promoting research integrity, was 11% in the 2-year period 2009-2010.

Laparoendoscopic single site in pelvic surgery

PubMed Central

Sanchez-Salas, Rafael; Clavijo, Rafael; Barret, Eric; Sotelo, Rene

2012-01-01

Laparoendoscopic single site (LESS) has recently gained momentum as feasible techniques for minimal access surgery. Our aim is to describe the current status of laparoendoscopic single site (LESS) in pelvic surgery. A comprehensive revision of the literature in LESS pelvic surgery was performed. References for this manuscript were obtained by performing a review of the available literature in PubMed from 01-01-01 to 30-11-11. References outside the search period were obtained selected manuscript΄s bibliography. Search terms included: pelvic anatomy, less in gynecology, single port colectomy, urological less, single port, single site, NOTES, LESS and single incision. 314 manuscripts were initially identified. Out of these, 46 manuscripts were selected based in their pelvic anatomy or surgical content; including experimental experience, clinical series and literature reviews. LESS drastically limit the surgeon's ability to perform in the operative field and the latter becomes hardened by the lack of space in anatomical location like the pelvis. Potential advantages of LESS are gained with the understanding that the surgical procedure is more technically challenging. Pelvic surgical procedures related to colorectal surgery, gynecology and urology have been performed with LESS technique and information available is mostly represented by case reports and short case series. Comparative series remain few. LESS pelvic surgery remain in its very beginning and due to the very specific anatomical conditions further development of LESS surgery in the mentioned area can be clearly be facilitated by using robotic technology. Standardization ad reproducibility of techniques are mandatory to further develop LESS in the surgical arena.. PMID:22557719

How Static is the Statics Classroom? An investigation into how innovations, specifically Research-Based Instructional Strategies, are adopted into the Statics Classroom

NASA Astrophysics Data System (ADS)

Cutler, Stephanie Leigh

The purpose of this dissertation is to investigate how educational research, specifically Research-Based Instructional Strategies (RBIS), is adopted by education practice, specifically within the engineering Statics classroom. Using a systematic approach, changes in classroom teaching practices were investigated from the instructors' perspective. Both researchers and practitioners are included in the process, combining efforts to improve student learning, which is a critical goal for engineering education. The study is divided into 3 stages and each is discussed in an individual manuscript. Manuscript 1 provides an assessment of current teaching practices; Manuscript 2 explores RBIS use by Statics instructors and perceived barriers of adoption; and Manuscript 3 evaluates adoption using Fidelity of Implementation. A common set of concurrent mixed methods was used for each stage of this study. A quantitative national survey of Statics instructors (n =166) and 18 qualitative interviews were conducted to examine activities used in the Statics classroom and familiarity with nine RBIS. The results of this study show that lecturing is the most common activity throughout Statics classrooms, but is not the only activity. Other common activities included working examples and students working on problems individually and in groups. As discussed by the interview participants, each of Rogers' characteristics influenced adoption for different reasons. For example, Complexity (level of difficulty with implementation of an RBIS) was most commonly identified as a barrier. His study also evaluated the Fidelity of Implementation for each RBIS and found it to be higher for RBIS that were less complex (in terms of the number of critical components). Many of the critical components (i.e. activities required for implementation, as described in the literature) were found to statistically distinguish RBIS users and non-users. This dissertation offers four contributions: (1) an understanding of current practices in Statics; (2) the instructor perspective of the barriers to using RBIS in the classroom; (3) the use of Fidelity of Implementation as a unique evaluation of RBIS adoption, which can be used by future engineering education researchers; and (4) a systematic approach of exploring change in the classroom, which offers new perspectives and approaches to accelerate the adoption process.

Comprehensive Approaches to Multiphase Flows in Geophysics - Application to nonisothermal, nonhomogenous, unsteady, large-scale, turbulent dusty clouds I. Hydrodynamic and Thermodynamic RANS and LES Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Dartevelle

2005-09-05

The objective of this manuscript is to fully derive a geophysical multiphase model able to ''accommodate'' different multiphase turbulence approaches; viz., the Reynolds Averaged Navier-Stokes (RANS), the Large Eddy Simulation (LES), or hybrid RANSLES. This manuscript is the first part of a larger geophysical multiphase project--lead by LANL--that aims to develop comprehensive modeling tools for large-scale, atmospheric, transient-buoyancy dusty jets and plume (e.g., plinian clouds, nuclear ''mushrooms'', ''supercell'' forest fire plumes) and for boundary-dominated geophysical multiphase gravity currents (e.g., dusty surges, diluted pyroclastic flows, dusty gravity currents in street canyons). LES is a partially deterministic approach constructed on either amore » spatial- or a temporal-separation between the large and small scales of the flow, whereas RANS is an entirely probabilistic approach constructed on a statistical separation between an ensemble-averaged mean and higher-order statistical moments (the so-called ''fluctuating parts''). Within this specific multiphase context, both turbulence approaches are built up upon the same phasic binary-valued ''function of presence''. This function of presence formally describes the occurrence--or not--of any phase at a given position and time and, therefore, allows to derive the same basic multiphase Navier-Stokes model for either the RANS or the LES frameworks. The only differences between these turbulence frameworks are the closures for the various ''turbulence'' terms involving the unknown variables from the fluctuating (RANS) or from the subgrid (LES) parts. Even though the hydrodynamic and thermodynamic models for RANS and LES have the same set of Partial Differential Equations, the physical interpretations of these PDEs cannot be the same, i.e., RANS models an averaged field, while LES simulates a filtered field. In this manuscript, we also demonstrate that this multiphase model fully fulfills the second law of thermodynamics and fulfills the necessary requirements for a well-posed initial-value problem. In the next manuscripts, we will further develop specific closures for multiphase RANS, LES, and hybrid-LES.« less

Improved Time to Publication in Journal of Geophysical Research-Atmospheres

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Gouw, Joost A.; Ghan, Steven J.; Pryor, Sara

Timely publication of manuscripts is important to authors and readers. AGU has significantly accelerated both the review and production processes for the Journal of Geophysical Research-Atmospheres (JGR-Atmospheres). Via a number of mechanisms (e.g., shortening the time allotted for reviewer selection, manuscript reviews, and revisions), the mean time to first decision has been decreased from 98 days in 2007 to 50 days in 2011, and the mean time to final decision has been decreased from 132 days in 2007 to 71 days in 2011. By implementing a new content management system, adjusting the workflow for improved efficiency, requesting authors to proofreadmore » their manuscripts quicker, and improving monitoring and follow-up to author and vendor queries, the mean production time from manuscript acceptance to publication has been decreased from 128 days in 2010 to only 56 days in 2012. Thus, in the past few years the mean time to publication of JGRAtmospheres has been cut in half. These milestones have been achieved with no loss of quality of presentation or content. In addition, online posting of "papers in press" on JGR-Atmosphere’s home page typically occurs within a few days after acceptance. JGR-Atmospheres editors thank manuscript reviewers, authors, and AGU staff who have greatly contributed to the more timely review and publication processes. This information will be updated periodically on the JGR-Atmospheres home page. A chart showing the average time from acceptance to publication for all of AGU’s journals is available at http://www.agu.org/pubs/pdf/31May2012_Timeliness_Chart.pdf.« less

Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention.

PubMed

Fox, Caroline S; Gurary, Ellen B; Ryan, John; Bonaca, Marc; Barry, Karen; Loscalzo, Joseph; Massaro, Joseph

2016-04-27

A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. Original article manuscripts were randomized to social media exposure compared with no social media exposure (control) at Circulation beginning in January 2015. Social media exposure consisted of Facebook and Twitter posts on the journal's accounts. To increase social media intensity, a larger base of followers was built using advertising and organic growth, and posts were presented in triplicate and boosted on Facebook and retweeted on Twitter. The primary outcome was 30-day page views. Stopping rules were established at the point that 50% of the manuscripts were randomized and had 30-day follow-up to compare groups on 30-day page views. The trial was stopped for futility on September 26, 2015. Overall, 74 manuscripts were randomized to receive social media exposure, and 78 manuscripts were randomized to the control arm. The intervention and control arms were similar based on article type (P=0.85), geographic location of the corresponding author (P=0.33), and whether the manuscript had an editorial (P=0.80). Median number of 30-day page views was 499.5 in the social media arm and 450.5 in the control arm; there was no evidence of a treatment effect (P=0.38). There were no statistically significant interactions of treatment by manuscript type (P=0.86), by corresponding author (P=0.35), by trimester of publication date (P=0.34), or by editorial status (P=0.79). A more intensive social media strategy did not result in increased 30-day page views of original research. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

D'Nealian Manuscript--An Aid to Reading Development.

ERIC Educational Resources Information Center

Thurber, Donald N.

A new method of continuous stroke manuscript print called D'Nealian Manuscript is challenging the traditional circle-stick method of teaching children how to write. The circle-stick uses component or splinter parts to form whole letters. Children are forced to form all writing with verticle lines and to learn a manuscript print that goes nowhere.…

Management of Hypoparathyroidism: Summary Statement and Guidelines.

PubMed

Brandi, Maria Luisa; Bilezikian, John P; Shoback, Dolores; Bouillon, Roger; Clarke, Bart L; Thakker, Rajesh V; Khan, Aliya A; Potts, John T

2016-06-01

Hypoparathyroidism is a rare disorder characterized by hypocalcemia and absent or deficient PTH. This report presents a summary of current information about epidemiology, presentation, diagnosis, clinical features, and management and proposes guidelines to help clinicians diagnose, evaluate, and manage this disorder. Participants in the First International Conference on the Management of Hypoparathyroidism represented a worldwide constituency with acknowledged interest and expertise in key basic, translational, and clinical aspects of hypoparathyroidism. Three Workshop Panels were constituted to address questions for presentation and discussion at the Conference held in Florence, Italy, May 7-9, 2015. At that time, a series of presentations were made, followed by in-depth discussions in an open forum. Each Workshop Panel also met in closed sessions to formulate the three evidence-based reports that accompany this summary statement. An Expert Panel then considered this information, developed summaries, guidelines, and a research agenda that constitutes this summary statement. Preceding the conference, each Workshop Panel conducted an extensive literature search as noted in the individual manuscripts accompanying this report. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. This report represents the Expert Panel's synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of hypoparathyroidism. This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of hypoparathyroidism.

TH-C-204-01: Vision for Medical Physics and Status of Current Initiatives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williamson, J.

In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is “to continue the Journal’s tradition of publishing the very best science that propels ourmore » discipline forward and improves our contribution to patient care.” More concretely, the Journal should be the preeminent forum for exchange of cutting edge medical physics science. We seek to identify the best contributions in (a) high impact clinical physics innovations; (b) clinical translation and validation of basic science innovations; and (c) cutting edge basic science developments with potential for patient care improvements. Among the challenges and opportunities, we face are: electronic-only and open access publishing; competition from new radiological science journals; trends towards more interactive, social-media based scientific communities; and diversification of the medical physics research, authorship, and readership domains, including clinical applications quite foreign to core ABR clinical competencies. Recently implemented and ongoing initiatives include: Revised Table of Contents (TOC) and more contemporary topical submission categories Structured review template in HTML format Comprehensive hierarchical taxonomy for identifying reviewer expertise Formal process for soliciting high quality and impact Review and Vision 20/20 Articles We have recruited four Review Article Co-editors: John Rowlands and Ingrid Reiser (imaging physics) and Joao Seco and Tim Zhu (therapy physics). The Co-Editors will identify timely topics and solicit high profile authors to submit review manuscripts. To submit an article, authors will need to work with an assigned Co-Editor to develop a mutually acceptable outline and abstract. 5) A new and exciting class of articles: Medical Physics Dataset Articles (MPDAs) MPDAs describe scientifically or clinically valuable open-access datasets with high potential for contributing to the research of medical physicists working on related problems. In contrast to Research Articles, MPDAs should not include hypothesis testing; or data analyses supporting generalizable conclusions. The publically accessible dataset must be permanently archived before the MPDA can be published. This initiative is being led by Joe Deasy. Update on new publisher transition: The transition of AAPM scientific publishing operations to a major publishing house is a major opportunity to expand Medical Physics readership and its scholarly impact. The advantages include: (a) common manuscript management and web hosting platforms for Medical Physics and its sister journal, JACMP; (b) greater than 4-fold expansion of subscribing institutions; and (c) resources to mount data-driven, highly targeted marketing campaigns to enhance citation and download rates. A transition update of this epochal development, which has only begun as of this writing (3/31/16), will be given. Improving manuscript quality via structured reviews, enhanced scientific category taxonomy, and outreach: Shiva Das, Therapy Physics Editor Medical Physics is committed to continuous improvement with the ultimate goal of improving the potential impact of accepted manuscripts. In order to do so, Medical Physics must be able to tap into important/emerging areas and be able to select high quality contributions consistently via discerning reviews. Improving the quality of reviews is crucial to selecting high quality manuscripts and also to improving manuscript impact via feedback in the review process. With this in mind, Medical Physics is in the process of: (a) fostering outreach to important areas that are currently underrepresented in Medical Physics; (b) implementing a structured template review form; and (c) implementing a comprehensive scientific category taxonomy to identify reviewers who are best suited to an article. Outreach efforts have begun to various scientific areas. Strategies to increase submissions from these areas will be discussed. As a consequence of this effort, a special issue on particle therapy is under development. A review template was implemented in late 2014 on a limited test basis. Based on reviewer feedback, the template was restructured and shortened to capture essential review elements. The restructured template is due to be released shortly. The new scientific category taxonomy is in the process of being deployed to reviewers and associate editors. Salient aspects of the structured review template and scientific category taxonomy will be discussed in this talk. Writing good scientific papers and responding to critiques: Mitch Goodsitt, Imaging Physics Editor The essential components of the abstract, introduction, methods, discussion and conclusion sections of manuscripts, as well as the desired writing style and style of the figures and tables will be reviewed. Publishable Medical Physics manuscripts must include clear and concise statements of the novelty and clinical and/or scientific importance of the authors’ work. Examples of novelty include: new technical solution to an important clinical problem; new generalizable knowledge; and first demonstration that an existing engineering solution solves a clinical problem. Please note that we encourage authors of recently published conference proceedings (e.g., SPIE, IEEE) papers on novel medical physics related work to submit more substantial versions of that work to our journal. All submissions must include: sufficient background information and rationale; enough detail for others to reproduce the authors’ work; sufficient statistical analysis to refute or validate the authors’ hypotheses; a description of how the present work compares to, is distinct from, and improves upon others’ work; and sections devoted to the limitations of the study and future directions. Writing should be polished. Poor wording, grammar and composition frustrate the review process. Our journal does not have copyeditors for revising manuscripts. When authors receive critiques from the referees and associate editor, the authors should provide a detailed point-by-point response to each comment. The authors’ rebuttal should include the text of the original criticism, the authors’ response, and a pasted copy of the modified text along with the line numbers in the revised article. The new text should be highlighted in a different font color in the revised submission. Following these recommendations will improve submissions and facilitate the review process.« less

Rotor instrumentation circuits for the Sandia 34-meter vertical axis wind turbine

NASA Astrophysics Data System (ADS)

Sutherland, Herbert J.; Stephenson, William A.

1988-07-01

Sandia National Laboratories has erected a research oriented, 34-meter diameter, Darrieus vertical axis wind turbine near Bushland, Texas, which has been designated the Sandia 34-m VAWT Test Bed. To meet present and future research needs, the machine was equipped with a large array of sensors. This manuscript details the sensors initially placed on the rotor, their respective instrumentation circuits, and the provisions incorporated into the design of the rotor instrumentation circuits for future research. This manuscript was written as a reference manual for the rotor instrumentation of the Test Bed.

Receiver design, performance analysis, and evaluation for space-borne laser altimeters and space-to-space laser ranging systems

NASA Technical Reports Server (NTRS)

Davidson, Frederic M.; Sun, Xiaoli; Field, Christopher T.

1995-01-01

This Interim report consists of a manuscript, 'Receiver Design for Satellite to Satellite Laser Ranging Instrument,' and copies of two papers we co-authored, 'Demonstration of High Sensitivity Laser Ranging System' and 'Semiconductor Laser-Based Ranging Instrument for Earth Gravity Measurements. ' These two papers were presented at the conference Semiconductor Lasers, Advanced Devices and Applications, August 21 -23, 1995, Keystone Colorado. The manuscript is a draft in the preparation for publication, which summarizes the theory we developed on space-borne laser ranging instrument for gravity measurements.

[Drugs of a Baroque monastery pharmacy].

PubMed

Drábek, Pavel

2013-08-01

This paper deal with a manuscript from the years 1714-1720, originating most probably from the hospital of the Brothers of Mercy in Nové Mesto nad Metují. it contains the records of the hospital pharmacy about the drugs prepared for both patients and monks who operated this hospital. The included drugs were mainly intended for elderly males. The manuscript lists about fifteen hundred drugs and more than three hundred active ingredients, of which about two thirds were of plant origin. The paper presents the compositions of more important drugs and partly deals also with their preparation.

Sensor Systems Based on FPGAs and Their Applications: A Survey

PubMed Central

de la Piedra, Antonio; Braeken, An; Touhafi, Abdellah

2012-01-01

In this manuscript, we present a survey of designs and implementations of research sensor nodes that rely on FPGAs, either based upon standalone platforms or as a combination of microcontroller and FPGA. Several current challenges in sensor networks are distinguished and linked to the features of modern FPGAs. As it turns out, low-power optimized FPGAs are able to enhance the computation of several types of algorithms in terms of speed and power consumption in comparison to microcontrollers of commercial sensor nodes. We show that architectures based on the combination of microcontrollers and FPGA can play a key role in the future of sensor networks, in fields where processing capabilities such as strong cryptography, self-testing and data compression, among others, are paramount.

An Evidence-Based Review on Medicinal Value of Clays in Traditional Persian Medicine.

PubMed

Hosseinkhani, Ayda; Montaseri, Hashem; Hosamo, Ammar; Zarshenas, Mohammad Mehdi

2017-01-01

The use of earths and clays for medical purposes dates back to antiquity. In recent years, there has been an increasing interest in researches on traditional remedies in the hope of discovering new drug. Iran is an ancient country with a medical backbone acquired from the experiences of ancient Persian scholars, who had made a great contribution to the development of the medical sciences. Many medical and pharmaceutical books by early Persian scientists still exist and may have the potential of leading researchers to new drug discoveries. Owing to the emergence of new and antimicrobial-resistant infections, present-day medicine has recently begun focusing on medicinal earths and clays especially as mineral antimicrobials. The current study is, therefore, aimed at gathering information regarding medicinal clays in traditional Persian medicine (TPM). Five main Persian materia medica with the key word 'tin' (clay) and current databases such as PubMed, Scopus, ScienceDirect, and Google Scholar were searched by key words 'white, green, red, maroon, violet, black, grey and pink clays' and 'pharmacological effects'. Twenty three clays were found in Persian manuscripts. Although their mineralogical compositions are unknown, different pharmacological properties have been attributed to these mineral medicaments. Clay's properties were widely used in medieval times for the treatment of infections to poisoning. They were also used in compound formulations, possibly for their pharmaceutical formulation modifying effects. Modern scientific proofs have also been found in many of the medicinal clays reported in Persian manuscripts. Although many of the reported clays are still unknown, their characterization may lead to new medicinal developments. Novel analytical methods available today make it possible to elucidate the chemical compositions of these minerals as parameters responsible for their medicinal effects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Routine screening of harmful microorganisms in beach sands: implications to public health

USGS Publications Warehouse

Sabino, Raquel; Rodrigues, R.; Costa, I.; Carneiro, Carlos; Cunha, M.; Duarte, A.; Faria, N.; Ferriera, F.C.; Gargate, M.J.; Julio, C.; Martins, M.L.; Nevers, Meredith; Oleastro, M.; Solo-Gabriele, H.; Verissimo, C.; Viegas, C.; Whitman, Richard L.; Brandao, J.

2014-01-01

Beaches worldwide provide recreational opportunities to hundreds of millions of people and serve as important components of coastal economies. Beach water is often monitored for microbiological quality to detect the presence of indicators of human sewage contamination so as to prevent public health outbreaks associated with water contact. However, growing evidence suggests that beach sand can harbor microbes harmful to human health, often in concentrations greater than the beach water. Currently, there are no standards for monitoring, sampling, analyzing, or managing beach sand quality. In addition to indicator microbes, growing evidence has identified pathogenic bacteria, viruses, and fungi in a variety of beach sands worldwide. The public health threat associated with these populations through direct and indirect contact is unknown because so little research has been conducted relating to health outcomes associated with sand quality. In this manuscript, we present the consensus findings of a workshop of experts convened in Lisbon, Portugal to discuss the current state of knowledge on beach sand microbiological quality and to develop suggestions for standardizing the evaluation of sand at coastal beaches. The expert group at the “Microareias 2012” workshop recommends that 1) beach sand should be screened for a variety of pathogens harmful to human health, and sand monitoring should then be initiated alongside regular water monitoring; 2) sampling and analysis protocols should be standardized to allow proper comparisons among beach locations; and 3) further studies are needed to estimate human health risk with exposure to contaminated beach sand. Much of the manuscript is focused on research specific to Portugal, but similar results have been found elsewhere, and the findings have worldwide implications.

From Rejected to Accepted: Part 2--Preparing a Rejected Manuscript for a New Journal

ERIC Educational Resources Information Center

Stivers, Jan; Cramer, Sharon F.

2017-01-01

Manuscript rejection is a fact of life for academics, and should be seen as just one step in a process of revision and resubmission that typically results in publication. This manuscript is the second in a two-part series offering suggestions to help authors take action on their rejected manuscripts, including analyzing reviewer feedback, revising…

A Literature Investigation about Electrospinning and Nanofibers: Historical Trends, Current Status and Future Challenges.

PubMed

Nascimento, Marcio L F; Araújo, Evando S; Cordeiro, Erlon R; de Oliveira, Ariadne H P; de Oliveira, Helinando P

2015-01-01

The development of new fibrilar materials based on electrospinning (ES) technique has a notable history of nearly four centuries of discoveries and results. The eletrospinning manufacturing is one of the most widely reported methods for nanofiber (NF) manufacturing, providing security, high quality and productivity. In spite of the first patent about electrospinning has been applied in April 5(th), 1900 by John Francis Cooley, a historical perspective (since 1600s) about this amazing discovery represents an important step for future applications. Nanofibers have been considered one of the top interesting fundamental study objects for academicians, and greatest intriguing business materials for modern industry. As a consequence, lucrative organizations and companies have explored the relevance of nanofibers. In this paper, the quantity of published manuscripts and patent inventions is presented and the correlation of research activities to the production of new electrospinning materials is shown. China and the United States have been leading in electrospinning and nanofibers development. The company triumph is mostly dependent on applications improvement relevant for broader business society. A dramatic rise of interest in nanofibers produced by electrospinning technique has been confirmed due to the publication data, author's affiliation, keywords, and essential characterization procedures. Is has been shown that the number of publications on electrospinning and nanofibers researches from academic institutions is higher than industrial laboratories. More than 1,891 patents using the term "electrospinning" and 2,960 with the term "nanofibers" according to the European Patent Office at title or abstract have been filed around the world up to 2013. These numbers just continue to increase along with worldwide ES-related sales. Curiously, for the same period 11,973 electrospinning documents and 18,679 nanofibers-related (mainly manuscripts) were published considering the Scopus database with the same terms in the title, abstract or using keywords. Thus, statistically, there are more published manuscripts worldwide than patents for both keywords.

Survey on Inadequate and Omitted Citations in Manuscripts: A Precursory Study in Identification of Tasks for a Literature Review and Manuscript Writing Assistive System

ERIC Educational Resources Information Center

Raamkumar, Aravind Sesagiri; Foo, Schubert; Pang, Natalie

2016-01-01

Introduction: This paper looks at the issue of inadequate and omitted citations in manuscripts by collecting the experiential opinions of researchers from the dual perspectives of manuscript reviewers and authors. Method: An online survey was conducted with participation from 207 respondents who had experience of reviewing and authoring research…

Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

ERIC Educational Resources Information Center

Amare, Nicole; Manning, Alan

2009-01-01

Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

Experiencing Emotion across a Semester-Long Family Role-Play and Reflecting Team: Implications for Counselor Development

ERIC Educational Resources Information Center

Harrawood, Laura K.; Parmanand, Shawn; Wilde, Brandon J.

2011-01-01

The use of role-play and reflecting teams have been established as acceptable practices in the education of counselors-in-training. However, the current counseling literature does not identify the range of emotion experienced by students, as they participate in experiential activities. This manuscript identifies the emotions experienced by…

Fragment-Based Approaches to Enhance GTP Competitive KRAS G12C Inhibitors

DTIC Science & Technology

During the current period we completed work on a series of guanine nucleotide mimetics and published results. As part of this we developed and...reported a novel method of measuring small molecule binding to KRAS G12C active site. We also published 2 additional manuscripts about KRAS G12C directed

Putting Meaning Back Into the Mean: A Comment on the Misuse of Elementary Statistics in a Sample of Manuscripts Submitted to Clinical Therapeutics.

PubMed

Forrester, Janet E

2015-12-01

Errors in the statistical presentation and analyses of data in the medical literature remain common despite efforts to improve the review process, including the creation of guidelines for authors and the use of statistical reviewers. This article discusses common elementary statistical errors seen in manuscripts recently submitted to Clinical Therapeutics and describes some ways in which authors and reviewers can identify errors and thus correct them before publication. A nonsystematic sample of manuscripts submitted to Clinical Therapeutics over the past year was examined for elementary statistical errors. Clinical Therapeutics has many of the same errors that reportedly exist in other journals. Authors require additional guidance to avoid elementary statistical errors and incentives to use the guidance. Implementation of reporting guidelines for authors and reviewers by journals such as Clinical Therapeutics may be a good approach to reduce the rate of statistical errors. Copyright © 2015 Elsevier HS Journals, Inc. All rights reserved.

[The processes of manuscript evaluation and publication in Medicina Clínica. The editorial committee of Medicina Clínica].

PubMed

Ribera, Josep M; Cardellach, Francesc; Selva, Albert

2005-12-01

The decision-making process includes a series of activities undertaken in biomedical journals from the moment a manuscript is received until it is accepted or rejected. Firstly, the manuscript is evaluated by the members of the Editorial Board, who analyze both its suitability for the journal and its scientific quality. After this initial evaluation, the article is evaluated by peer reviewers, an essential process to guarantee its scientific validity. Both the Editorial Board and the peer reviewers usually use checklists which are of enormous help in this task. Once the biomedical article has been accepted, the publication process is started, which in turn includes a series of steps, beginning with technical and medical review of the article's contents and ending with the article's publication in the journal. The present article provides a detailed description of the main technical and ethical issues involved in the processes of decision-making and publication of biomedical articles.

Einstein's steady-state theory: an abandoned model of the cosmos

NASA Astrophysics Data System (ADS)

O'Raifeartaigh, Cormac; McCann, Brendan; Nahm, Werner; Mitton, Simon

2014-09-01

We present a translation and analysis of an unpublished manuscript by Albert Einstein in which he attempted to construct a `steady-state' model of the universe. The manuscript, which appears to have been written in early 1931, demonstrates that Einstein once explored a cosmic model in which the mean density of matter in an expanding universe is maintained constant by the continuous formation of matter from empty space. This model is very different to previously known Einsteinian models of the cosmos (both static and dynamic) but anticipates the later steady-state cosmology of Hoyle, Bondi and Gold in some ways. We find that Einstein's steady-state model contains a fundamental flaw and suggest that it was abandoned for this reason. We also suggest that he declined to explore a more sophisticated version because he found such theories rather contrived. The manuscript is of historical interest because it reveals that Einstein debated between steady-state and evolving models of the cosmos decades before a similar debate took place in the cosmological community.

Management of intestinal failure in middle-income countries, for children and adults.

PubMed

Gondolesi, Gabriel E; Pattín, Francisco; Nikkoupur, Hamed

2018-04-01

Intestinal failure is a life-threatening medical condition that remains as a rare or orphan disease in most countries. The prevalence of intestinal failure and the therapeutic options available in middle-income countries (MIC) remain unclear. We aim to provide an overview on the current differences in management of intestinal failure patients in MIC from Latin America and Asia. In order to fulfil the challenge, and after facing the difficulties of going over a topic with scarce available data, from countries with an extreme variety of social and economic problems, which are closely related to the treatment of intestinal failure patients, we have used both the existing publications and personal surveys to draft this document. Our results have shown that there is still significant disparity among MIC over the last years, concepts such as the need for establishing multidisciplinary dedicated teams as well as the need to evolve first home parenteral nutrition (HPN), then rehabilitation, and finally transplantation, have become important signals of an adequate understanding of this evolving field. The manuscript presents, for the first time, an overview of the different developments and needs to manage intestinal failure patients in MIC from Latin America and Asia. Future discussions will emerge from this manuscript, aiming to pursue the development of registries, guidelines and health policies to continue improving the long-term care of intestinal failure patients in all MIC.

Fertility and pregnancy issues in BRCA-mutated breast cancer patients.

PubMed

Lambertini, Matteo; Goldrat, Oranite; Toss, Angela; Azim, Hatem A; Peccatori, Fedro A; Ignatiadis, Michail; Del Mastro, Lucia; Demeestere, Isabelle

2017-09-01

Fertility and pregnancy-related issues represent one of the main areas of concerns for young women with breast cancer. Carrying a germline deleterious BRCA mutation adds additional burden on this regard due to the specific issues that should be considered during the oncofertility counseling of this special patient group. Despite the availability of a growing amount of data in the general breast cancer population on the feasibility and safety of fertility preservation and pregnancy after diagnosis, numerous challenges remain for BRCA-mutated breast cancer patients in whom very limited studies have been performed so far. Therefore, studies aiming to address the specific issues of these patients, including the impact of the mutation on their fertility potential, the safety and efficacy of the different strategies for fertility preservation, and the feasibility of having a pregnancy after diagnosis, should be considered a research priority. The aim of the present manuscript is to perform an in depth overview on the role of BRCA mutations in breast cancer with a specific focus on their impact on reproductive potential, and to discuss the fertility and pregnancy issues faced by BRCA-mutated breast cancer patients. The final goal of this manuscript is to highlight current and upcoming knowledge in this field for trying to help physicians dealing with these patients during oncofertility counseling. Copyright © 2017 Elsevier Ltd. All rights reserved.

Writing Research Reports.

PubMed

Sessler, Daniel I; Shafer, Steven

2018-01-01

Clear writing makes manuscripts easier to understand. Clear writing enhances research reports, increasing clinical adoption and scientific impact. We discuss styles and organization to help junior investigators present their findings and avoid common errors.

Nasal Drug Delivery in Traditional Persian Medicine

PubMed Central

Zarshenas, Mohammad Mehdi; Zargaran, Arman; Müller, Johannes; Mohagheghzadeh, Abdolali

2013-01-01

Background Over one hundred different pharmaceutical dosage forms have been recorded in literatures of Traditional Persian Medicine among which nasal forms are considerable. Objectives This study designed to derive the most often applied nasal dosage forms together with those brief clinical administrations. Materials and Methods In the current study remaining pharmaceutical manuscripts of Persia during 9th to 18th century AD have been studied and different dosage forms related to nasal application of herbal medicines and their therapeutic effects were derived. Results By searching through pharmaceutical manuscripts of medieval Persia, different nasal dosage forms involving eleven types related to three main groups are found. These types could be derived from powder, solution or liquid and gaseous forms. Gaseous form were classified into fumigation (Bakhoor), vapor bath (Enkebab), inhalation (Lakhlakheh), aroma agents (Ghalieh) and olfaction or smell (Shomoom). Nasal solutions were as drops (Ghatoor), nasal snuffing drops (Saoot) and liquid snuff formulations (Noshoogh). Powders were as nasal insufflation or snorting agents (Nofookh) and errhine or sternutator medicine (Otoos). Nasal forms were not applied only for local purposes. Rather systemic disorders and specially CNS complications were said to be a target for these dosage forms. Discussion While this novel type of drug delivery is known as a suitable substitute for oral and parenteral administration, it was well accepted and extensively mentioned in Persian medical and pharmaceutical manuscripts and other traditional systems of medicine as well. Accordingly, medieval pharmaceutical standpoints on nasal dosage forms could still be an interesting subject of study. Therefore, the current work can briefly show the pharmaceutical knowledge on nasal formulations in medieval Persia and clarify a part of history of traditional Persian pharmacy. PMID:24624204

Hindrance of conservation biology by delays in the submission of manuscripts.

PubMed

O'Donnell, Ryan P; Supp, Sarah R; Cobbold, Stephanie M

2010-04-01

Timely dissemination of scientific findings depends not only on rapid publication of submitted manuscripts, a topic which has received much discussion, but also on rapid submission of research after the research is completed. We measured submission delay (time from the last date of data collection to the submission of a manuscript) for every paper from 14 journals in 2007 and compared these submission delays among four fields of biology (conservation, taxonomy, behavior, and evolution). Manuscripts published in leading journals in the field of conservation biology have the longest delays in publication of accepted manuscripts and the longest intervals between completion of research and submission of the manuscript. Delay in manuscript submission accounts for more than half of the total time from last date of data collection to publication. Across fields, the number of authors was significantly negatively correlated with submission delay, but conservation journals had the second highest number of authors and the greatest submission delay, so submission of conservation manuscripts was not hindered by a shortage of collaboration relative to other fields. Rejection rates were greater in conservation journals than in behavior and evolution, but rejection times were faster; thus, there were no obvious net differences among fields in the time papers spent waiting to be rejected. Publication delay has been reduced significantly in the last 7 years, but was still greater in conservation journals than in any of the other three fields we studied. Thus, the urgent field of conservation biology is hindered in both preparation and publication of manuscripts.

Quantifying the effect of editor-author relations on manuscript handling times.

PubMed

Sarigöl, Emre; Garcia, David; Scholtes, Ingo; Schweitzer, Frank

2017-01-01

In this article we study to what extent the academic peer review process is influenced by social relations between the authors of a manuscript and the editor handling the manuscript. Taking the open access journal PlosOne as a case study, our analysis is based on a data set of more than 100,000 articles published between 2007 and 2015. Using available data on handling editor, submission and acceptance time of manuscripts, we study the question whether co-authorship relations between authors and the handling editor affect the manuscript handling time , i.e. the time taken between the submission and acceptance of a manuscript. Our analysis reveals (1) that editors handle papers co-authored by previous collaborators significantly more often than expected at random, and (2) that such prior co-author relations are significantly related to faster manuscript handling. Addressing the question whether these shorter manuscript handling times can be explained by the quality of publications, we study the number of citations and downloads which accepted papers eventually accumulate. Moreover, we consider the influence of additional (social) factors, such as the editor's experience, the topical similarity between authors and editors, as well as reciprocal citation relations between authors and editors. Our findings show that, even when correcting for other factors like time, experience, and performance, prior co-authorship relations have a large and significant influence on manuscript handling times, speeding up the editorial decision on average by 19 days.

State-of-the-art: dental photocuring--a review.

PubMed

Rueggeberg, Frederick A

2011-01-01

Light curing in dentistry has truly revolutionized the practice of this art and science. With the exception bonding to tooth structure, there is perhaps no single advancement that has promoted the ease, efficiency, productivity, and success of performing dentistry. Like most every major advancements in this profession, the technology underlying the successful application of light curing in dentistry did not arise from within the profession, but instead was the result of innovative adaptations in applying new advances to clinical treatment. One cannot appreciate the current status of dental photocuring without first appreciating the history and innovations of the science and industry underlying the advances from which it developed. This review will place the current status of the art within the context of its historical progression, enabling a better appreciation for the benefits and remaining issues that photocuring has brought us. Lastly, the manuscript will present thoughts for future considerations in the field, offering suggestions as to how current advances in light-generating science might yet be adapted for dental use. Copyright © 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Hiring a professional medical writer: is it equivalent to ghostwriting?

PubMed Central

Das, Natasha; Das, Saurendra

2014-01-01

Authors of articles published in medical journals are often busy researchers who cannot afford time devoted to writing. Though they are experts in their own therapeutic area, more often than not, researchers find it difficult to actually write and publish their research. Professional medical writers with their expertise in writing clear, concise, comprehensible, and coherent content are often a great support to researchers. Their contribution to the manuscript is usually focused on getting a manuscript ready for publication. They are not authors unless they make substantial contribution to the study according to the guidelines of the International Committee of Medical Journal Editors (ICMJE). However, medical writing is not the same as ghostwriting. Ghostwriting is unethical. Medical writers can be legitimate contributors to the medical manuscript. Several international guidelines including the ICMJE guidelines require authors to acknowledge the contribution of medical writers in the published article. Medical writers whose name is publicly associated with the article in turn make an extra effort to ensure that all applicable publication ethics and style guidelines are adhered to. This article discusses the current international guidelines about the acknowledgement of writing assistance. It also emphasizes on how acknowledging medical writing support can go a long way in curbing the menace of scientific misconduct including ghostwriting. PMID:24627711

Hiring a professional medical writer: is it equivalent to ghostwriting?

PubMed

Das, Natasha; Das, Saurendra

2014-01-01

Authors of articles published in medical journals are often busy researchers who cannot afford time devoted to writing. Though they are experts in their own therapeutic area, more often than not, researchers find it difficult to actually write and publish their research. Professional medical writers with their expertise in writing clear, concise, comprehensible, and coherent content are often a great support to researchers. Their contribution to the manuscript is usually focused on getting a manuscript ready for publication. They are not authors unless they make substantial contribution to the study according to the guidelines of the International Committee of Medical Journal Editors (ICMJE). However, medical writing is not the same as ghostwriting. Ghostwriting is unethical. Medical writers can be legitimate contributors to the medical manuscript. Several international guidelines including the ICMJE guidelines require authors to acknowledge the contribution of medical writers in the published article. Medical writers whose name is publicly associated with the article in turn make an extra effort to ensure that all applicable publication ethics and style guidelines are adhered to. This article discusses the current international guidelines about the acknowledgement of writing assistance. It also emphasizes on how acknowledging medical writing support can go a long way in curbing the menace of scientific misconduct including ghostwriting.

Implementation and Outcomes of a Faculty-Based, Peer Review Manuscript Writing Workshop.

PubMed

Kulage, Kristine M; Larson, Elaine L

2016-01-01

The publication of scholarly work and research findings is an important expectation for nursing faculty; however, academic writing is often neglected, leaving dissemination through manuscript writing an area of concern for the nursing profession. Writing initiatives have been utilized to promote scholarly dissemination in schools of nursing, but those described in the literature have been primarily non-United States based and student focused. This article describes a faculty-based manuscript writing workshop, assesses participants' impressions, and describes its impact on scholarly output. The workshop is a collaborative learning process utilizing peer review to improve manuscript quality and model behaviors for improving writing and peer-reviewing skills. Seventeen workshop participants including three predoctoral students, 6 postdoctoral fellows, and 8 faculty members completed an anonymous workshop survey (81% response rate). All but 1 of 17 manuscripts reviewed in the workshop are published, accepted, or in the review process. All participants indicated that the workshop was a valuable use of time and would recommend it to colleagues. The greatest reported workshop benefit was its function as an impetus to complete and submit manuscripts. We recommend the manuscript writing workshop model for other schools of nursing seeking ways to expand their scholarly output and create accountability for dissemination through manuscript writing. Copyright © 2016 Elsevier Inc. All rights reserved.

Muller's Nobel Prize Lecture: when ideology prevailed over science.

PubMed

Calabrese, Edward J

2012-03-01

This paper extends and confirms the report of Calabrese (Calabrese, E. J. (2011b). Muller's Nobel Lecture on dose-response for ionizing radiation: Ideology or science? Arch. Toxicol. 85, 1495-1498) that Hermann J. Muller knowingly made deceptive comments in his 1946 Nobel Prize Lecture (Muller, H. J. (1946). Nobel Prize Lecture. Stockholm, Sweden. Available at http://www.nobelprize.org/. Accessed December 12) concerning the dose-response. Supporting a linearity perspective, Muller stated there is "no escape from the conclusion that there is no threshold" while knowing the results of a recent study by Ernst Caspari and Curt Stern contradicted these comments. Recently uncovered private correspondence between Muller and Stern reveals Muller's scientific assessment of the Caspari and Stern manuscript in a letter from Muller to Stern 5 weeks (14 January 1947) after his Nobel Prize Lecture of 12 December 1946. Muller indicated that the manuscript was of acceptable scientific quality; he indicated the manuscript should be published, but the findings needed replication because it significantly challenged the linearity hypothesis. These findings complement the previous letter (12 November 1946 letter from Muller to Stern), which revealed that Muller received the Caspari and Stern manuscript, recognized it as significant, and recommended its replication 5 weeks before his Nobel Prize Lecture. Muller therefore supported this position immediately before and after his Nobel Prize Lecture. Muller's opinions on the Caspari and Stern manuscript therefore had not changed during the time leading up to his Lecture, supporting the premise that his Lecture comments were deceptive. These findings are of historical and practical significance because Muller's comments were a notable contributory factor, changing how risks would be assessed for carcinogens (i.e., changing from a threshold to a linear model) throughout the 20th century to the present.

A prospective study on an innovative online forum for peer reviewing of surgical science

PubMed Central

von Allmen, Regula S.; Carradice, Dan; Oosterling, Steven J.; McFarlane, Kirsty; Wijnhoven, Bas

2017-01-01

Background Peer review is important to the scientific process. However, the present system has been criticised and accused of bias, lack of transparency, failure to detect significant breakthrough and error. At the British Journal of Surgery (BJS), after surveying authors’ and reviewers’ opinions on peer review, we piloted an open online forum with the aim of improving the peer review process. Methods In December 2014, a web-based survey assessing attitudes towards open online review was sent to reviewers with a BJS account in Scholar One. From April to June 2015, authors were invited to allow their manuscripts to undergo online peer review in addition to the standard peer review process. The quality of each review was evaluated by editors and editorial assistants using a validated instrument based on a Likert scale. Results The survey was sent to 6635 reviewers. In all, 1454 (21.9%) responded. Support for online peer review was strong, with only 10% stating that they would not subject their manuscripts to online peer review. The most prevalent concern was about intellectual property, being highlighted in 118 of 284 comments (41.5%). Out of 265 eligible manuscripts, 110 were included in the online peer review trial. Around 7000 potential reviewers were invited to review each manuscript. In all, 44 of 110 manuscripts (40%) received 100 reviews from 59 reviewers, alongside 115 conventional reviews. The quality of the open forum reviews was lower than for conventional reviews (2.13 (± 0.75) versus 2.84 (± 0.71), P<0.001). Conclusion Open online peer review is feasible in this setting, but it attracts few reviews, of lower quality than conventional peer reviews. PMID:28662046

A prospective study on an innovative online forum for peer reviewing of surgical science.

PubMed

Almquist, Martin; von Allmen, Regula S; Carradice, Dan; Oosterling, Steven J; McFarlane, Kirsty; Wijnhoven, Bas

2017-01-01

Peer review is important to the scientific process. However, the present system has been criticised and accused of bias, lack of transparency, failure to detect significant breakthrough and error. At the British Journal of Surgery (BJS), after surveying authors' and reviewers' opinions on peer review, we piloted an open online forum with the aim of improving the peer review process. In December 2014, a web-based survey assessing attitudes towards open online review was sent to reviewers with a BJS account in Scholar One. From April to June 2015, authors were invited to allow their manuscripts to undergo online peer review in addition to the standard peer review process. The quality of each review was evaluated by editors and editorial assistants using a validated instrument based on a Likert scale. The survey was sent to 6635 reviewers. In all, 1454 (21.9%) responded. Support for online peer review was strong, with only 10% stating that they would not subject their manuscripts to online peer review. The most prevalent concern was about intellectual property, being highlighted in 118 of 284 comments (41.5%). Out of 265 eligible manuscripts, 110 were included in the online peer review trial. Around 7000 potential reviewers were invited to review each manuscript. In all, 44 of 110 manuscripts (40%) received 100 reviews from 59 reviewers, alongside 115 conventional reviews. The quality of the open forum reviews was lower than for conventional reviews (2.13 (± 0.75) versus 2.84 (± 0.71), P<0.001). Open online peer review is feasible in this setting, but it attracts few reviews, of lower quality than conventional peer reviews.

Working Papers in Art Education, 1989-1990.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1990-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this double volume the works are organized by sponsoring university. Student papers presented are: (1) "Looking, Talking, and Experiencing Art with Preschoolers" (Shari…

Working Papers in Art Education, 1991.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1991-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by sponsoring university. Student papers presented are: (1) "Interpreting Museums as Cultural Metaphors" (Michael Sikes); (2) "Key…

Publish or perish: writing clinical manuscripts suitable for publication.

PubMed

Batcheller, Joyce; Kirksey, Kenn M; VanDyke, Yvonne; Armstrong, Myrna L

2012-01-01

A successful hospital network and university faculty collaboration offered 21 staff nurses and nurse leaders opportunities to develop clinical manuscripts that would be suitable for publishing their innovative ideas. This process prepared them to synthesize relevant literature and develop their ideas into manuscripts. Ten nurses submitted their final manuscripts to refereed journals, and nine individuals or team members had their articles accepted. These accepted publications provided a boost to individual career development and stimulated further valuable professional dissemination goals. One major challenge was to seek further ways to find time to write while working in today's health care arena. Suggestions for future manuscript development are provided. Copyright 2012, SLACK Incorporated.

Preparing a scientific manuscript in Linux: Today's possibilities and limitations.

PubMed

Tchantchaleishvili, Vakhtang; Schmitto, Jan D

2011-10-22

Increasing number of scientists are enthusiastic about using free, open source software for their research purposes. Authors' specific goal was to examine whether a Linux-based operating system with open source software packages would allow to prepare a submission-ready scientific manuscript without the need to use the proprietary software. Preparation and editing of scientific manuscripts is possible using Linux and open source software. This letter to the editor describes key steps for preparation of a publication-ready scientific manuscript in a Linux-based operating system, as well as discusses the necessary software components. This manuscript was created using Linux and open source programs for Linux.

Publication patterns and citation analysis of APJTM during 2008 and June 2014.

PubMed

Lei, Yan; Tan, Bei-Jia; Zou, Zhou; Zhang, Ming-Ming; Song, Rui-Pu; Qu, Shun-Hai; Li, Jing

2014-08-01

To draw on data about publication patterns and citation indicators of Asian Pacific Journal of Tropical Medicine (APJTM) during 2008 and June 2014 in order to know about the current state of the journal. Data used in this study were collected based on publications in APJTM from 2008 to June, 2014. Information including publication issue, type of manuscript, country/region of Corresponding author, funded research paper, and international collaboration were aggregated and analyzed with Excel software. Citation indicators including total cites, average cites of each manuscript, h-index, and impact factors were primarily drawn from Web of Science™ database on June 15, 2014 and changes over the past six and half years were interpreted. The top 10 most cited papers in Web of Science™ database were also analyzed. Number of all submissions has arisen from less than 200 in 2008 to over 1 500 in 2013, manuscript acceptance rate has decreased to be less than 14.00% indicating its improvement in quality over this period of time. Out of the 1 115 publiations, 23.77% were fruits of funded projects or produced by funded co-authors, 87.08% of all publications in APJTM were submited by authors from 10 most contributed countries. During the studied period, each published manuscript in the journal has received an average of 1.05 cites, and at least 10 publications has been cited for more 10 times. Detailed analysis shows APJTM has made great progress over the past six and half years, but authors' originating countries are still disproportionate. Efforts should be made to improve its citation indicators. Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

The fate of triaged and rejected manuscripts.

PubMed

Zoccali, Carmine; Amodeo, Daniela; Argiles, Angel; Arici, Mustafa; D'arrigo, Graziella; Evenepoel, Pieter; Fliser, Danilo; Fox, Jonathan; Gesualdo, Loreto; Jadoul, Michel; Ketteler, Markus; Malyszko, Jolanta; Massy, Ziad; Mayer, Gert; Ortiz, Alberto; Sever, Mehmet; Vanholder, Raymond; Vinck, Caroline; Wanner, Christopher; Więcek, Andrzej

2015-12-01

In 2011, Nephrology Dialysis and Transplantation (NDT) established a more restrictive selection process for manuscripts submitted to the journal, reducing the acceptance rate from 25% (2008-2009) to currently about 12-15%. To achieve this goal, we decided to score the priority of manuscripts submitted to NDT and to reject more papers at triage than in the past. This new scoring system allows a rapid decision for the authors without external review. However, the risk of such a restrictive policy may be that the journal might fail to capture important studies that are eventually published in higher-ranked journals. To look into this problem, we analysed random samples of papers (∼10%) rejected by NDT in 2012. Of the papers rejected at triage and those rejected after regular peer review, 59 and 61%, respectively, were accepted in other journals. A detailed analysis of these papers showed that only 4 out of 104 and 7 out of 93 of the triaged and rejected papers, respectively, were published in journals with an impact factor higher than that of NDT. Furthermore, for all these papers, independent assessors confirmed the evaluation made by the original reviewers. The number of citations of these papers was similar to that typically obtained by publications in the corresponding journals. Even though the analyses seem reassuring, previous observations made by leading journals warn that the risk of 'big misses', resulting from selective editorial policies, remains a real possibility. We will therefore continue to maintain a high degree of alertness and will periodically track the history of manuscripts rejected by NDT, particularly papers that are rejected at triage by our journal. © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

TH-C-204-02: Improving Manuscript Quality Via Structured Reviews, Enhanced Scientific Category Taxonomy, and Outreach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, S.

In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is “to continue the Journal’s tradition of publishing the very best science that propels ourmore » discipline forward and improves our contribution to patient care.” More concretely, the Journal should be the preeminent forum for exchange of cutting edge medical physics science. We seek to identify the best contributions in (a) high impact clinical physics innovations; (b) clinical translation and validation of basic science innovations; and (c) cutting edge basic science developments with potential for patient care improvements. Among the challenges and opportunities, we face are: electronic-only and open access publishing; competition from new radiological science journals; trends towards more interactive, social-media based scientific communities; and diversification of the medical physics research, authorship, and readership domains, including clinical applications quite foreign to core ABR clinical competencies. Recently implemented and ongoing initiatives include: Revised Table of Contents (TOC) and more contemporary topical submission categories Structured review template in HTML format Comprehensive hierarchical taxonomy for identifying reviewer expertise Formal process for soliciting high quality and impact Review and Vision 20/20 Articles We have recruited four Review Article Co-editors: John Rowlands and Ingrid Reiser (imaging physics) and Joao Seco and Tim Zhu (therapy physics). The Co-Editors will identify timely topics and solicit high profile authors to submit review manuscripts. To submit an article, authors will need to work with an assigned Co-Editor to develop a mutually acceptable outline and abstract. 5) A new and exciting class of articles: Medical Physics Dataset Articles (MPDAs) MPDAs describe scientifically or clinically valuable open-access datasets with high potential for contributing to the research of medical physicists working on related problems. In contrast to Research Articles, MPDAs should not include hypothesis testing; or data analyses supporting generalizable conclusions. The publically accessible dataset must be permanently archived before the MPDA can be published. This initiative is being led by Joe Deasy. Update on new publisher transition: The transition of AAPM scientific publishing operations to a major publishing house is a major opportunity to expand Medical Physics readership and its scholarly impact. The advantages include: (a) common manuscript management and web hosting platforms for Medical Physics and its sister journal, JACMP; (b) greater than 4-fold expansion of subscribing institutions; and (c) resources to mount data-driven, highly targeted marketing campaigns to enhance citation and download rates. A transition update of this epochal development, which has only begun as of this writing (3/31/16), will be given. Improving manuscript quality via structured reviews, enhanced scientific category taxonomy, and outreach: Shiva Das, Therapy Physics Editor Medical Physics is committed to continuous improvement with the ultimate goal of improving the potential impact of accepted manuscripts. In order to do so, Medical Physics must be able to tap into important/emerging areas and be able to select high quality contributions consistently via discerning reviews. Improving the quality of reviews is crucial to selecting high quality manuscripts and also to improving manuscript impact via feedback in the review process. With this in mind, Medical Physics is in the process of: (a) fostering outreach to important areas that are currently underrepresented in Medical Physics; (b) implementing a structured template review form; and (c) implementing a comprehensive scientific category taxonomy to identify reviewers who are best suited to an article. Outreach efforts have begun to various scientific areas. Strategies to increase submissions from these areas will be discussed. As a consequence of this effort, a special issue on particle therapy is under development. A review template was implemented in late 2014 on a limited test basis. Based on reviewer feedback, the template was restructured and shortened to capture essential review elements. The restructured template is due to be released shortly. The new scientific category taxonomy is in the process of being deployed to reviewers and associate editors. Salient aspects of the structured review template and scientific category taxonomy will be discussed in this talk. Writing good scientific papers and responding to critiques: Mitch Goodsitt, Imaging Physics Editor The essential components of the abstract, introduction, methods, discussion and conclusion sections of manuscripts, as well as the desired writing style and style of the figures and tables will be reviewed. Publishable Medical Physics manuscripts must include clear and concise statements of the novelty and clinical and/or scientific importance of the authors’ work. Examples of novelty include: new technical solution to an important clinical problem; new generalizable knowledge; and first demonstration that an existing engineering solution solves a clinical problem. Please note that we encourage authors of recently published conference proceedings (e.g., SPIE, IEEE) papers on novel medical physics related work to submit more substantial versions of that work to our journal. All submissions must include: sufficient background information and rationale; enough detail for others to reproduce the authors’ work; sufficient statistical analysis to refute or validate the authors’ hypotheses; a description of how the present work compares to, is distinct from, and improves upon others’ work; and sections devoted to the limitations of the study and future directions. Writing should be polished. Poor wording, grammar and composition frustrate the review process. Our journal does not have copyeditors for revising manuscripts. When authors receive critiques from the referees and associate editor, the authors should provide a detailed point-by-point response to each comment. The authors’ rebuttal should include the text of the original criticism, the authors’ response, and a pasted copy of the modified text along with the line numbers in the revised article. The new text should be highlighted in a different font color in the revised submission. Following these recommendations will improve submissions and facilitate the review process.« less

Dilated cerebral venous system observed in growth-restricted fetuses.

PubMed

Baron, Joel; Mastrolia, Salvatore Andrea; Shelef, Ilan; Tirosh, Dan; Daniel-Spiegel, Etty; Hershkovitz, Reli

2018-05-01

The dilation of the fetal cerebral veins is a rare phenomenon that may be associated to a bad obstetric outcome, and is usually connected to antenatal thrombosis of the posterior dural venous sinuses. There are several descriptions of cerebral vein distension on magnetic resonance imaging (MRI), but all of them are detected postnatally. We present herein two cases of fetal antenatal cerebral dilation of the venous system, without any association to any sign of vein thrombosis, and a systematic review of literature regarding pathogenesis, diagnosis and outcomes associated to the antenatal detection of this condition with the use of MRI. To identify potentially eligible studies, we searched PubMed, Scopus, Cochrane Library (all from inception to October 20th, 2016) and applied no language restrictions. The electronic database search provided a total of 22,843 results. After the exclusion of duplicates, manuscripts that resulted not relevant to the review based on title and abstract screening, and analysis of manuscripts eligible for full-text assessment, no papers were found related to the subject reported in the present manuscript. Our report adds importance to MRI as a tool in cases of complex ultrasound finding with the presence of fetal heart failure and deterioration of fetal growth, in order to improve the prognostic evaluation and patient?s counseling.

Estimation of Bottom Trawl Catch Efficiency for Two Demersal Fishes, Atlantic Croaker and White Perch in Chesapeake Bay

EPA Science Inventory

We present an efficiency analysis of a fisheries-independent demersal trawl survey in Chesapeake Bay, the largest estuary in the United States, that is presently being used for multi-species fisheries assessment and management. The manuscript presents an in situ analysis of demer...

Proceedings of papers presented at the 2nd international symposium on applications of biotechnology to tree culture, protection, and utilization.

Treesearch

Charles H. Michler; Michael R. Becwar; Daniel Cullen; Warren L. Nance; Ronald R. Sederoff; James M. Silvicek

1994-01-01

Contains 38 oral presentation abstracts, 34 poster abstracts, and 18 manuscripts on applications of biotechnology to tree research in the areas of stress resistance, protection, and wood utilization presented at an international conference in Bloomington, Minnesota, October 2-6, 1994.

Note: Expanding the bandwidth of the ultra-low current amplifier using an artificial negative capacitor.

PubMed

Xie, Kai; Liu, Yan; Li, XiaoPing; Guo, Lixin; Zhang, Hanlu

2016-04-01

The bandwidth and low noise characteristics are often contradictory in ultra-low current amplifier, because an inevitable parasitic capacitance is paralleled with the high value feedback resistor. In order to expand the amplifier's bandwidth, a novel approach was proposed by introducing an artificial negative capacitor to cancel the parasitic capacitance. The theory of the negative capacitance and the performance of the improved amplifier circuit with the negative capacitor are presented in this manuscript. The test was conducted by modifying an ultra-low current amplifier with a trans-impedance gain of 50 GΩ. The results show that the maximum bandwidth was expanded from 18.7 Hz to 3.3 kHz with more than 150 times of increase when the parasitic capacitance (∼0.17 pF) was cancelled. Meanwhile, the rise time decreased from 18.7 ms to 0.26 ms with no overshot. Any desired bandwidth or rise time within these ranges can be obtained by adjusting the ratio of cancellation of the parasitic and negative capacitance. This approach is especially suitable for the demand of rapid response to weak current, such as transient ion-beam detector, mass spectrometry analysis, and fast scanning microscope.

Use of Non-invasive Uterine Electromyography in the Diagnosis of Preterm Labour

PubMed Central

Lucovnik, M.; Novak-Antolic, Z.; Garfield, R.E.

2012-01-01

Predictive values of methods currently used in the clinics to diagnose preterm labour are low. This leads to missed opportunities to improve neonatal outcomes and, on the other hand, to unnecessary hospitalizations and treatments. In addition, research of new and potentially more effective preterm labour treatments is hindered by the inability to include only patients in true preterm labour into studies. Uterine electromyography (EMG) detects changes in cell excitability and coupling required for labour and has higher predictive values for preterm delivery than currently available methods. This methodology could also provide a better means to evaluate various therapeutic interventions for preterm labour. Our manuscript presents a review of uterine EMG studies examining the potential clinical value that this technology possesses over what is available to physicians currently. We also evaluated the impact that uterine EMG could have on investigation of preterm labour treatments by calculating sample sizes for studies using EMG vs. current methods to enrol women. Besides helping clinicians to make safer and more cost-effective decisions when managing patients with preterm contractions, implementation of uterine EMG for diagnosis of preterm labour would also greatly reduce sample sizes required for studies of treatments. PMID:24753891

["A" or ... "The" precious manuscript of the "Long life Elixir" just discovered].

PubMed

Grelaud, Jean-Pierre

2012-05-01

This study relates, describes, analyzes & comments the content of a recently discovered old manuscript, written probably at the beginning of the 18th century, and compares it with the well known "Long life Elixir, or Swedish Elixir", manuscript found on a Swedish doctor who died at 104 years old as a result of a fall from his horse... The origin of this new manuscript can be established from 1700 to 1710, and seems to be probably anterior to the well known Swedish manuscript, meanwhile the text is almost similar,... and also is more complete than this one! We learn that the "Manna" is synonymic here of "fine Rhubarb". Another recipe, unknown on the other manuscript and titled "Dalibour Water" is also published: By similar way, this formula brings some new details, in particular in the exact composition, the preparation and the use of the "Long Life Elixir".

Reporting Guidelines: Optimal Use in Preventive Medicine and Public Health

PubMed Central

Popham, Karyn; Calo, William A.; Carpentier, Melissa Y.; Chen, Naomi E.; Kamrudin, Samira A.; Le, Yen-Chi L.; Skala, Katherine A.; Thornton, Logan R.; Mullen, Patricia Dolan

2012-01-01

Numerous reporting guidelines are available to help authors write higher quality manuscripts more efficiently. Almost 200 are listed on the EQUATOR (Enhancing the Quality and Transparency of Health Research) Network’s website and they vary in authority, usability, and breadth, making it difficult to decide which one(s) to use. This paper provides consistent information about guidelines for preventive medicine and public health and a framework and sequential approach for selecting them. EQUATOR guidelines were reviewed for relevance to target audiences; selected guidelines were classified as “core” (frequently recommended) or specialized, and the latter were grouped by their focus. Core and specialized guidelines were coded for indicators of authority (simultaneous publication in multiple journals, rationale, scientific background supporting each element, expertise of designers, permanent website/named group), usability (presence of checklists and examples of good reporting), and breadth (manuscript sections covered). Discrepancies were resolved by consensus. Selected guidelines are presented in four tables arranged to facilitate selection: core guidelines, all of which pertain to major research designs; guidelines for additional study designs, topical guidelines, and guidelines for particular manuscript sections. A flow diagram provides an overview. The framework and sequential approach will enable authors as well as editors, peer reviewers, researchers, and systematic reviewers to make optimal use of available guidelines to improve the transparency, clarity, and rigor of manuscripts and research protocols and the efficiency of conducing systematic reviews and meta-analyses. PMID:22992369

ICMJE authorship criteria are not met in a substantial proportion of manuscripts submitted to Biochemia Medica.

PubMed

Šupak-Smolčić, Vesna; Mlinarić, Ana; Antončić, Dragana; Horvat, Martina; Omazić, Jelena; Šimundić, Ana-Maria

2015-01-01

Our aim was to investigate if: (a) authors of Biochemia Medica meet authorship criteria given by International Committee of Medical Journal Editors (ICMJE), (b) authorship violations are more frequent in submissions containing some type of scientific misconduct. Self-reported authorship contributions regarding the three ICMJE criteria were analysed for all submissions to Biochemia Medica (February 2013-April 2015) which were forwarded to peer-review. To test the differences in frequencies we used Chi-squared test. P<0.05 was considered statistically significant. 186 manuscripts were authored by 804 authors. All ICMJE criteria were met by 487/804 (61%) authors. The first and the last author met all the criteria more frequently than those authors in between (P<0.001). The degree to which ICMJE criteria was met for the first author did not differ between manuscripts authored by only one author and those authored by >1 author (P=0.859). In 9% of the manuscripts ICMJE criteria were not met by a single author. Authors of the 171/186 manuscripts declared that all persons qualify for authorship but only 49% of them satisfied all ICMJE criteria. Authors have failed to acknowledge contributors in 88/186 (47%) manuscripts; instead these contributors have been listed as authors without fulfilling ICMJE criteria. Authorship violation was not more common in 42 manuscripts with some type of scientific misconduct (P=0.135). Large proportion of authors of the manuscripts submitted to Biochemia Medica do not fulfil ICMJE criteria. Violation of authorship criteria is not more common for manuscripts with some type of scientific misconduct.

Material of Geographic Import in the National Anthropological Archives.

ERIC Educational Resources Information Center

Glenn, James R.

Presenting specific examples of the manuscripts, cartographic materials, and pictorial materials found in the National Anthropological Archives, this paper describes Archive holdings (in such areas as archeology, linguistics, physical anthropology, and various branches of ethnology) which are dated from 1850 to the present and are representative…

Comparative study of active plasma lenses in high-quality electron accelerator transport lines

NASA Astrophysics Data System (ADS)

van Tilborg, J.; Barber, S. K.; Benedetti, C.; Schroeder, C. B.; Isono, F.; Tsai, H.-E.; Geddes, C. G. R.; Leemans, W. P.

2018-05-01

Electrically discharged active plasma lenses (APLs) are actively pursued in compact high-brightness plasma-based accelerators due to their high-gradient, tunable, and radially symmetric focusing properties. In this manuscript, the APL is experimentally compared with a conventional quadrupole triplet, highlighting the favorable reduction in the energy dependence (chromaticity) in the transport line. Through transport simulations, it is explored how the non-uniform radial discharge current distribution leads to beam-integrated emittance degradation and a charge density reduction at focus. However, positioning an aperture at the APL entrance will significantly reduce emittance degradation without additional loss of charge in the high-quality core of the beam. An analytical model is presented that estimates the emittance degradation from a short beam driving a longitudinally varying wakefield in the APL. Optimizing laser plasma accelerator operation is discussed where emittance degradation from the non-uniform discharge current (favoring small beams inside the APL) and wakefield effects (favoring larger beam sizes) is minimized.

A unified framework for mesh refinement in random and physical space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jing; Stinis, Panos

In recent work we have shown how an accurate reduced model can be utilized to perform mesh renement in random space. That work relied on the explicit knowledge of an accurate reduced model which is used to monitor the transfer of activity from the large to the small scales of the solution. Since this is not always available, we present in the current work a framework which shares the merits and basic idea of the previous approach but does not require an explicit knowledge of a reduced model. Moreover, the current framework can be applied for renement in both randommore » and physical space. In this manuscript we focus on the application to random space mesh renement. We study examples of increasing difficulty (from ordinary to partial differential equations) which demonstrate the effciency and versatility of our approach. We also provide some results from the application of the new framework to physical space mesh refinement.« less

Informatics and Nursing in a Post-Nursing Informatics World: Future Directions for Nurses in an Automated, Artificially Intelligent, Social-Networked Healthcare Environment.

PubMed

Booth, Richard G

2016-01-01

The increased adoption and use of technology within healthcare and society has influenced the nursing informatics specialty in a multitude of fashions. Namely, the nursing informatics specialty currently faces a range of important decisions related to its knowledge base, established values and future directions - all of which are in need of development and future-proofing. In light of the increased use of automation, artificial intelligence and big data in healthcare, the specialty must also reconceptualize the roles of both nurses and informaticians to ensure that the nursing profession is ready to operate within future digitalized healthcare ecosystems. To explore these goals, the author of this manuscript outlines an examination of technological advancements currently taking place within healthcare, and also proposes implications for the nursing role and the nursing informatics specialty. Finally, recommendations and insights towards how the roles of nurses and informaticians might evolve or be shaped in the growing post-nursing informatics era are presented. Copyright © 2016 Longwoods Publishing.

Preparing a scientific manuscript in Linux: Today's possibilities and limitations

PubMed Central

2011-01-01

Background Increasing number of scientists are enthusiastic about using free, open source software for their research purposes. Authors' specific goal was to examine whether a Linux-based operating system with open source software packages would allow to prepare a submission-ready scientific manuscript without the need to use the proprietary software. Findings Preparation and editing of scientific manuscripts is possible using Linux and open source software. This letter to the editor describes key steps for preparation of a publication-ready scientific manuscript in a Linux-based operating system, as well as discusses the necessary software components. This manuscript was created using Linux and open source programs for Linux. PMID:22018246

Introduction to the Special Series: Current Directions for Measuring Parenting Constructs to Inform Prevention Science.

PubMed

Lindhiem, Oliver; Shaffer, Anne

2017-04-01

Parenting behaviors are multifaceted and dynamic and therefore challenging to quantify. Measurement methods have critical implications for study results, particularly for prevention trials designed to modify parenting behaviors. Although multiple approaches can complement one another and contribute to a more complete understanding of prevention trials, the assumptions and implications of each approach are not always clearly addressed. Greater attention to the measurement of complex constructs such as parenting is needed to advance the field of prevention science. This series examines the challenges of measuring changes in parenting behaviors in the context of prevention trials. All manuscripts in the special series address measurement issues and make practical recommendations for prevention researchers. Manuscripts in this special series include (1) empirical studies that demonstrate novel measurement approaches, (2) re-analyses of prevention trial outcome data directly comparing and contrasting two or more methods, and (3) a statistical primer and practical guide to analyzing proportion data.

Iterative Development of an Application to Support Nuclear Magnetic Resonance Data Analysis of Proteins.

PubMed

Ellis, Heidi J C; Nowling, Ronald J; Vyas, Jay; Martyn, Timothy O; Gryk, Michael R

2011-04-11

The CONNecticut Joint University Research (CONNJUR) team is a group of biochemical and software engineering researchers at multiple institutions. The vision of the team is to develop a comprehensive application that integrates a variety of existing analysis tools with workflow and data management to support the process of protein structure determination using Nuclear Magnetic Resonance (NMR). The use of multiple disparate tools and lack of data management, currently the norm in NMR data processing, provides strong motivation for such an integrated environment. This manuscript briefly describes the domain of NMR as used for protein structure determination and explains the formation of the CONNJUR team and its operation in developing the CONNJUR application. The manuscript also describes the evolution of the CONNJUR application through four prototypes and describes the challenges faced while developing the CONNJUR application and how those challenges were met.

Review of Potential Wind Tunnel Balance Technologies

NASA Technical Reports Server (NTRS)

Burns, Devin E.; Williams, Quincy L.; Phillips, Ben D.; Commo, Sean A.; Ponder, Jonathon D.

2016-01-01

This manuscript reviews design, manufacture, materials, sensors, and data acquisition technologies that may benefit wind tunnel balances for the aerospace research community. Current state-of-the-art practices are used as the benchmark to consider advancements driven by researcher and facility needs. Additive manufacturing is highlighted as a promising alternative technology to conventional fabrication and has the potential to reduce both the cost and time required to manufacture force balances. Material alternatives to maraging steels are reviewed. Sensor technologies including piezoresistive, piezoelectric, surface acoustic wave, and fiber optic are compared to traditional foil based gages to highlight unique opportunities and shared challenges for implementation in wind tunnel environments. Finally, data acquisition systems that could be integrated into force balances are highlighted as a way to simplify the user experience and improve data quality. In summary, a rank ordering is provided to support strategic investment in exploring the technologies reviewed in this manuscript.

A report on case reports

PubMed Central

Gopikrishna, Velayutham

2010-01-01

Case reports are defined as the scientific documentation of a single clinical observation and have a time-honored and rich tradition in medicine and scientific publication. This article discusses the role and relevance of case reports in the current evidence-based medical literature. It also seeks to help and guide authors to understand how to prepare a reasonable and well-written case report and how they may anticipate concerns that peer reviewers may express when scrutinizing their manuscript. An overview of the Journal of Conservative Dentistry’s review process of a manuscript submission is provided for the benefit of future authors. It is important to be able to read a case report critically and to use the information they contain appropriately. This article also discusses the factors to consider in evaluating individual case reports, and discusses a practical conceptual scheme for evaluating the potential value and educational content of a case report. PMID:21217956

Does a Graphical Abstract Bring More Visibility to Your Paper?

PubMed Central

Pferschy-Wenzig, Eva-Maria; Pferschy, Ulrich; Wang, Dongdong; Mocan, Andrei; Atanasov, Atanas G.

2017-01-01

A graphical abstract (GA) represents a piece of artwork that is intended to summarize the main findings of an article for readers at a single glance. Many publishers currently encourage authors to supplement their articles with GAs, in the hope that such a convenient visual summary will facilitate readers with a clearer outline of papers that are of interest and will result in improved overall visibility of the respective publication. To test this assumption, we statistically compared publications with or without GA published in Molecules between March 2014 and March 2015 with regard to several output parameters reflecting visibility. Contrary to our expectations, manuscripts published without GA performed significantly better in terms of PDF downloads, abstract views, and total citations than manuscripts with GA. To the best of our knowledge, this is the first empirical study on the effectiveness of GA for attracting attention to scientific publications. PMID:27649137

Does a Graphical Abstract Bring More Visibility to Your Paper?

PubMed

Pferschy-Wenzig, Eva-Maria; Pferschy, Ulrich; Wang, Dongdong; Mocan, Andrei; Atanasov, Atanas G

2016-09-18

A graphical abstract (GA) represents a piece of artwork that is intended to summarize the main findings of an article for readers at a single glance. Many publishers currently encourage authors to supplement their articles with GAs, in the hope that such a convenient visual summary will facilitate readers with a clearer outline of papers that are of interest and will result in improved overall visibility of the respective publication. To test this assumption, we statistically compared publications with or without GA published in Molecules between March 2014 and March 2015 with regard to several output parameters reflecting visibility. Contrary to our expectations, manuscripts published without GA performed significantly better in terms of PDF downloads, abstract views, and total citations than manuscripts with GA. To the best of our knowledge, this is the first empirical study on the effectiveness of GA for attracting attention to scientific publications.

The Library as Publisher.

ERIC Educational Resources Information Center

Field, Roy

1979-01-01

Presents a guide to for-profit library publishing of reprints, original manuscripts, and smaller items. Discussed are creation of a publications panel to manage finances and preparation, determining prices of items, and drawing up author contracts. (SW)

The Scholarship of Teaching and Learning in Teaching Sociology: 1973-2009

ERIC Educational Resources Information Center

Paino, Maria; Blankenship, Chastity; Grauerholz, Liz; Chin, Jeffrey

2012-01-01

This article updates and extends research by Baker and Chin, who tracked changes in studies published in Teaching Sociology from 1973 to 1983 (Baker) and 1984 to 1999 (Chin). The current study traces manuscripts published in "Teaching Sociology" from 2000 to 2009. We examine both who publishes in the journal and what gets published. In particular,…

Pearls and pitfalls of deformity correction and limb lengthening via monolateral external fixation.

PubMed Central

Noonan, K. J.; Price, C. T.

1996-01-01

In conclusion, monolateral external fixation can be effectively utilized in the management of limb length discrepancy and angular deformity. This manuscript outlines the pertinent theory, application and problems important in these cases. When faced with specific congenital conditions the surgeon is encouraged to reference relevant literature that is more focused than the current paper. PMID:9129275

Measuring Academic Productivity and Changing Definitions of Scientific Impact

PubMed Central

Sarli, Cathy C.; Carpenter, Christopher R.

2016-01-01

This manuscript provides a brief overview of the history of communication of scientific research and reporting of scientific research impact outcomes. Current day practices are outlined along with examples of how organizations and libraries are providing tools to evaluate and document the impact of scientific research to provide a meaningful narrative suitable for a variety of purposes and audiences. PMID:25438359

Invited Reaction: Protecting the Birds' Feathers--Keeping Ideology out of MBA and HRD Programs

ERIC Educational Resources Information Center

Bowman, Jeffry S.

2007-01-01

In reference to Peter Kuchinke's manuscript, the author points out that current MBA programs suffer from a myriad of ills that are somehow detrimental to organizations and that there is a similar problem with human resource development (HRD) programs (hence the reference in the title to "birds of a feather"). In this article, he shares his…

Nonergodic property of the space-time coupled CTRW: Dependence on the long-tailed property and correlation

NASA Astrophysics Data System (ADS)

Liu, Jian; Li, Baohe; Chen, Xiaosong

2018-02-01

The space-time coupled continuous time random walk model is a stochastic framework of anomalous diffusion with many applications in physics, geology and biology. In this manuscript the time averaged mean squared displacement and nonergodic property of a space-time coupled continuous time random walk model is studied, which is a prototype of the coupled continuous time random walk presented and researched intensively with various methods. The results in the present manuscript show that the time averaged mean squared displacements increase linearly with lag time which means ergodicity breaking occurs, besides, we find that the diffusion coefficient is intrinsically random which shows both aging and enhancement, the analysis indicates that the either aging or enhancement phenomena are determined by the competition between the correlation exponent γ and the waiting time's long-tailed index α.

Tips to Understanding and Writing Manuscript Abstracts

ERIC Educational Resources Information Center

Plakhotnik, Maria S.

2017-01-01

An abstract represents a short summary of key elements of the manuscript. The purpose of this essay is to discuss the function, contents, and types of manuscript abstracts. The essay concludes with a few tips for authors to writing effective abstracts.

Development of multifunctional materials exhibiting distributed sensing and actuation inspired by fish

NASA Astrophysics Data System (ADS)

Philen, Michael

2011-04-01

This manuscript is an overview of the research that is currently being performed as part of a 2009 NSF Office of Emerging Frontiers in Research and Innnovation (EFRI) grant on BioSensing and BioActuation (BSBA). The objectives of this multi-university collaborative research are to achieve a greater understanding of the hierarchical organization and structure of the sensory, muscular, and control systems of fish, and to develop advanced biologically-inspired material systems having distributed sensing, actuation, and intelligent control. New experimental apparatus have been developed for performing experiments involving live fish and robotic devices, and new bio-inspired haircell sensors and artificial muscles are being developed using carbonaceous nanomaterials, bio-derived molecules, and composite technology. Results demonstrating flow sensing and actuation are presented.

Caffeine-based food supplements and beverages: Trends of consumption for performance purposes and safety concerns.

PubMed

Bessada, Sílvia M F; Alves, Rita C; Oliveira, M Beatriz P P

2018-07-01

Nowadays, daily food supplementation regarding the improvement of physical and mental performance is a growing trend in sport practitioners, young students and active people. Food supplements are foodstuffs, labeled under food law and not obliged to safety assessments before their commercialization. Several products are commercialized claiming ergogenic effects as marketing strategies. Caffeine is often one of their main ingredients, as it increases both physical performance and concentration. This manuscript presents a general overview of the current caffeine-based food supplements and energy drinks available in the Portuguese market, as well as the consuming trends regarding their ergogenic effects, performance purposes, and active ingredients. Product claims, recommended daily intakes, caffeine pharmacology, and safety concerns aspects are also discussed aspects. Copyright © 2018 Elsevier Ltd. All rights reserved.

Editors' report, 2012.

PubMed

García-Puig, J; Alonso-Vega, G Gaspar; Ríos-Blanco, J J

2013-01-01

The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months: a) objectives and attainments; b) editorial activity; and c) objectives for 2013. In 2012 the most relevant modifications concerning the editorial activity have been: a) revision by the responsible editor of all manuscripts sent to peer review, and b) translation into English of five manuscripts with abstract of each issue. From the first January to the 30th September 2012 we handled 457 manuscripts (50 manuscripts per month) a figure 22.5% higher than in 2011 (40.8 manuscripts per month). We have accepted 27.2% of all manuscripts (originals, 13.0%). We asked for 295 revisions to 241 reviewers and we have received 66.1% of the revisions asked for in less than two weeks (mean time to receive a revision, 11.3 days). The mean time to adopt an editorial decision for all manuscripts («accept»/«reject») has been 23.9 days (31.3 days in 2011; 35.4 in 2010). This figure has been 29.4 days for the original manuscripts (9.5 and 12.3 days less than in 2011 and 2010, respectively). The mean time taken since a manuscript is received to publication has dropped from 203 days in 2010, 168 in 2011 and 115 in 2012 (less than 3 months). The collaboration with the working groups has reported 19 published manuscripts in 2012. We hope that in 2013 both the English version and the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000) will become a reality. The renewal of the actual sections (i.e., clinical conference, an image for a diagnosis) pretends, with the collaboration of all, to make our journal, each day, better. Copyright © 2012 Elsevier España, S.L. All rights reserved.

Determinants of physical activity and exercise in healthy older adults: A systematic review

PubMed Central

2011-01-01

Background The health benefits of regular physical activity and exercise have been widely acknowledged. Unfortunately, a decline in physical activity is observed in older adults. Knowledge of the determinants of physical activity (unstructured activity incorporated in daily life) and exercise (structured, planned and repetitive activities) is needed to effectively promote an active lifestyle. Our aim was to systematically review determinants of physical activity and exercise participation among healthy older adults, considering the methodological quality of the included studies. Methods Literature searches were conducted in PubMed/Medline and PsycINFO/OVID for peer reviewed manuscripts published in English from 1990 onwards. We included manuscripts that met the following criteria: 1) population: community dwelling healthy older adults, aged 55 and over; 2) reporting determinants of physical activity or exercise. The outcome measure was qualified as physical activity, exercise, or combination of the two, measured objectively or using self-report. The methodological quality of the selected studies was examined and a best evidence synthesis was applied to assess the association of the determinants with physical activity or exercise. Results Thirty-four manuscripts reporting on 30 studies met the inclusion criteria, of which two were of high methodological quality. Physical activity was reported in four manuscripts, exercise was reported in sixteen and a combination of the two was reported in fourteen manuscripts. Three manuscripts used objective measures, twenty-two manuscripts used self-report measures and nine manuscripts combined a self-report measure with an objective measure. Due to lack of high quality studies and often only one manuscript reporting on a particular determinant, we concluded "insufficient evidence" for most associations between determinants and physical activity or exercise. Conclusions Because physical activity was reported in four manuscripts only, the determinants of physical activity particularly need further study. Recommendations for future research include the use of objective measures of physical activity or exercise as well as valid and reliable measures of determinants. PMID:22204444

[Tracing back for the basis. Research of Medieval medical manuscripts in Leipzig by Karl Sudhoff and Henry Ernest Sigerist].

PubMed

Löffler, Anette

2009-01-01

At the beginning of the 20th century, two known medical historians, Karl Sudhoff and Henry Ernst Sigerist, were among the first persons, who took up thorough investigations of medical manuscripts in Leipzig. Above all, it was Mr. Sudhoff, who developed his own procedure, in order to exploit the unknown stocks. Apart from the only means available to him, the so-called Leyser-papers, written by the Leipzig librarian Hermann Leyser, at least once Sudhoff made a complete check-up of all manuscripts over the period of 22 years. On 315 sheets he took down various more or less extensive notes regarding these Codices, which are kept today as manuscript collection (Ms 01269) in the library of the university of Leipzig. Many publications were written on the basis of these readings. Sigerist was only looking through a small number of Leipzig manuscripts, as could be seen from his remarks written onto the users' cards. However, he could rely on Sudhoff's notes and look for specific manuscripts that he was interested in and review them. This was a first and very important step for the investigation of Leipzig medical manuscripts.

Ethical issues in studying submissions to a medical journal.

PubMed

Olson, C M; Glass, R M; Thacker, S B; Stroup, D F

1998-07-15

A protocol to prospectively study characteristics of meta-analyses submitted to a weekly medical journal raised several ethical issues. In submitting a manuscript for publication, authors do not implicitly consent to have their work used for research. Authors must be free to refuse to consent, without it affecting their chances for publication. Systematically analyzing data on manuscript characteristics might influence the decision to publish. Having investigators who are not on the editorial staff or peer reviewers extract the manuscripts' characteristics breaks the confidentiality of the author-editor-reviewer relationship. In response to these issues, we added a statement to our journal's instructions for authors that submitted manuscripts may be systematically analyzed to improve the quality of the editorial or peer review process. Authors had to actively consent to participate, but editors and external reviewers were unaware of which authors were participating. The manuscript characteristics were not shared with authors, editors, or external reviewers. The investigators were blinded to each manuscript's author and institution. After we addressed ethical issues encountered in studying manuscripts submitted to a medical journal, 99 of 105 authors submitting a meta-analysis during the study's first 24 months agreed to participate.

Quantitative Articles: Developing Studies for Publication in Counseling Journals

ERIC Educational Resources Information Center

Trusty, Jerry

2011-01-01

This article is presented as a guide for developing quantitative studies and preparing quantitative manuscripts for publication in counseling journals. It is intended as an aid for aspiring authors in conceptualizing studies and formulating valid research designs. Material is presented on choosing variables and measures and on selecting…

Working Papers in Art Education, 1988.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1988-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by sponsoring university. Student papers presented are: (1) "A Naturalistic Study of Art Choices in a Preschool Setting" (Karen Thomas);…

Working Papers in Art Education, 1992.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1992-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by the sponsoring university. Student papers presented are: (1) "How Will Moy, Chantale, Susan and Lola Make It through Art School?" (Miriam…

Working Papers in Art Education, 1994-1995.

ERIC Educational Resources Information Center

Thunder-McGuire, Steve, Ed.

1996-01-01

This publication presents manuscripts and research reports by graduate students. Accompanying papers from their mentors establish a context for the student papers. In this volume the works are organized by the sponsoring university. Student papers presented are: (1) "Looking at Feminist Pedagogies: What is Seen in the Literature and What is…

I Like, I Cite? Do Facebook Likes Predict the Impact of Scientific Work?

PubMed

Ringelhan, Stefanie; Wollersheim, Jutta; Welpe, Isabell M

2015-01-01

Due to the increasing amount of scientific work and the typical delays in publication, promptly assessing the impact of scholarly work is a huge challenge. To meet this challenge, one solution may be to create and discover innovative indicators. The goal of this paper is to investigate whether Facebook likes for unpublished manuscripts that are uploaded to the Internet could be used as an early indicator of the future impact of the scientific work. To address our research question, we compared Facebook likes for manuscripts uploaded to the Harvard Business School website (Study 1) and the bioRxiv website (Study 2) with traditional impact indicators (journal article citations, Impact Factor, Immediacy Index) for those manuscripts that have been published as a journal article. Although based on our full sample of Study 1 (N = 170), Facebook likes do not predict traditional impact indicators, for manuscripts with one or more Facebook likes (n = 95), our results indicate that the more Facebook likes a manuscript receives, the more journal article citations the manuscript receives. In additional analyses (for which we categorized the manuscripts as psychological and non-psychological manuscripts), we found that the significant prediction of citations stems from the psychological and not the non-psychological manuscripts. In Study 2, we observed that Facebook likes (N = 270) and non-zero Facebook likes (n = 84) do not predict traditional impact indicators. Taken together, our findings indicate an interdisciplinary difference in the predictive value of Facebook likes, according to which Facebook likes only predict citations in the psychological area but not in the non-psychological area of business or in the field of life sciences. Our paper contributes to understanding the possibilities and limits of the use of social media indicators as potential early indicators of the impact of scientific work.

I Like, I Cite? Do Facebook Likes Predict the Impact of Scientific Work?

PubMed Central

Ringelhan, Stefanie; Wollersheim, Jutta; Welpe, Isabell M.

2015-01-01

Due to the increasing amount of scientific work and the typical delays in publication, promptly assessing the impact of scholarly work is a huge challenge. To meet this challenge, one solution may be to create and discover innovative indicators. The goal of this paper is to investigate whether Facebook likes for unpublished manuscripts that are uploaded to the Internet could be used as an early indicator of the future impact of the scientific work. To address our research question, we compared Facebook likes for manuscripts uploaded to the Harvard Business School website (Study 1) and the bioRxiv website (Study 2) with traditional impact indicators (journal article citations, Impact Factor, Immediacy Index) for those manuscripts that have been published as a journal article. Although based on our full sample of Study 1 (N = 170), Facebook likes do not predict traditional impact indicators, for manuscripts with one or more Facebook likes (n = 95), our results indicate that the more Facebook likes a manuscript receives, the more journal article citations the manuscript receives. In additional analyses (for which we categorized the manuscripts as psychological and non-psychological manuscripts), we found that the significant prediction of citations stems from the psychological and not the non-psychological manuscripts. In Study 2, we observed that Facebook likes (N = 270) and non-zero Facebook likes (n = 84) do not predict traditional impact indicators. Taken together, our findings indicate an interdisciplinary difference in the predictive value of Facebook likes, according to which Facebook likes only predict citations in the psychological area but not in the non-psychological area of business or in the field of life sciences. Our paper contributes to understanding the possibilities and limits of the use of social media indicators as potential early indicators of the impact of scientific work. PMID:26244779

External funding of obstetrical publications: citation significance and trends over 2 decades.

PubMed

Vintzileos, William S; Ananth, Cande V; Vintzileos, Anthony M

2013-08-01

The objective of the study was to identify the external funding status of the most frequently cited obstetrical publications (citation classics) and to assess trends in funded vs nonfunded manuscripts as well as each publication's type of external funding. For the first objective, the citation classics, which were reported in a previous publication, were reviewed to identify their funding status. For the second objective, all pregnancy-related and obstetrical publications from the 2 US-based leading journals, the American Journal of Obstetrics and Gynecology and Obstetrics and Gynecology, were reviewed to identify the funding status and trends between 1989 and 2012. Twenty-seven of 44 of the citation classics (61%) had external funding, whereas only 43% of the reviewed regular (non-citation classic) obstetrical publications had external funding. There was a decreasing trend in the number of obstetrical manuscripts associated with a decreasing trend in the number and proportion of nonfunded manuscripts and an increasing trend in the number and proportion of National Institutes of Health (NIH)-funded manuscripts. Relative to 1989, in 2012 there was a 34.8% decrease in the number of published obstetrical manuscripts, a 59.6% decrease in the number of nonfunded manuscripts, and a 6.8% increase in the number of funded manuscripts accompanied by an 8.2% increase in the number of NIH-funded publications. In the last 9 years (2004-2012), there was a 35.1% increase in the proportion of NIH-funded manuscripts accompanied by an 18.8% decrease in the proportion of non-NIH-funded manuscripts. Our findings provide useful data regarding the importance of securing NIH-based funding for physicians contemplating academic careers in obstetrics. Copyright © 2013 Mosby, Inc. All rights reserved.

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.

PubMed

Bourdon-Lacombe, Julie A; Moffat, Ivy D; Deveau, Michelle; Husain, Mainul; Auerbach, Scott; Krewski, Daniel; Thomas, Russell S; Bushel, Pierre R; Williams, Andrew; Yauk, Carole L

2015-07-01

Toxicogenomics promises to be an important part of future human health risk assessment of environmental chemicals. The application of gene expression profiles (e.g., for hazard identification, chemical prioritization, chemical grouping, mode of action discovery, and quantitative analysis of response) is growing in the literature, but their use in formal risk assessment by regulatory agencies is relatively infrequent. Although additional validations for specific applications are required, gene expression data can be of immediate use for increasing confidence in chemical evaluations. We believe that a primary reason for the current lack of integration is the limited practical guidance available for risk assessment specialists with limited experience in genomics. The present manuscript provides basic information on gene expression profiling, along with guidance on evaluating the quality of genomic experiments and data, and interpretation of results presented in the form of heat maps, pathway analyses and other common approaches. Moreover, potential ways to integrate information from gene expression experiments into current risk assessment are presented using published studies as examples. The primary objective of this work is to facilitate integration of gene expression data into human health risk assessments of environmental chemicals. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

Ketamine - A Multifaceted Drug.

PubMed

Meng, Lingzhong; Li, Jian; Lu, Yi; Sun, Dajin; Tao, Yuan-Xiang; Liu, Renyu; Luo, Jin Jun

There is a petition for tight control of ketamine from the Chinese government to classify ketamine as a Schedule I drug, which is defined as a drug with no currently accepted medical use but a high potential for abuse. However, ketamine has unique properties that can benefit different patient populations. Scholars from the Translational Perioperative and Pain Medicine and the International Chinese Academy of Anesthesiology WeChat groups had an interactive discussion on ketamine, including its current medical applications, future research priorities, and benefits versus risks. The discussion is summarized in this manuscript with some minor edits.

Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biftu, Tesfaye; Sinha-Roy, Ranabir; Chen, Ping

In our effort to discover DPP-4 inhibitors with added benefits over currently commercially available DPP-4 inhibitors, MK-3102 (omarigliptin), was identified as a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor with an excellent pharmacokinetic profile amenable for once-weekly human dosing and selected as a clinical development candidate. This manuscript summarizes the mechanism of action, scientific rationale, medicinal chemistry, pharmacokinetic properties, and human efficacy data for omarigliptin, which is currently in phase 3 clinical development.

[Manuscript "Many different remedies for headache treatment" from the archives of Sinj Friary].

PubMed

Kujundzic, Nikola; Glibota, Milan; Inic, Suzana

2011-01-01

Manuscripts containing collections of folk recipes for treatment of deseases were written mostly by Catholic priests especially Franciscians in Croatia in the past centuries. They were used as manuals for preparation of remedies and gave directions for their use. These writtings provide valuble data for etnographers and historians of ethnomedicine. The paper describes the manuscript "Many different remedies for headache treatment" written by unknown author probably in 18. century in Sinj, Dalmatia. The manuscript was found in the archives of Sinj Friary. The collection contains 16 recipes for headache treatment. Materia medica of the manuscript is composed of drugs of plant origin. Valuable information is given about the folk names for medicinal plants as well as descriptions of the ways of preparing remedies. Latin as well as contemporaly croatian names are attributed to the plants species mentioned in the manuscript. Use of the plants for treatment of the specific deseases were compared with their use in modern fitotherapy.

The use of a multi-method approach to identify the pigments in the 12th century manuscript Liber Floridus

NASA Astrophysics Data System (ADS)

Deneckere, A.; De Reu, M.; Martens, M. P. J.; De Coene, K.; Vekemans, B.; Vincze, L.; De Maeyer, Ph.; Vandenabeele, P.; Moens, L.

2011-10-01

A selection of illuminations of the 12th century manuscript Liber Floridus was analysed with Raman spectroscopy (in situ and laboratory measurements), X-ray fluorescence spectroscopy, UV-fluorescence photography and infrared reflectography (IRR). The aim of this study is to determine the pigments used, in order to search for anachronisms. Using a combination of Raman spectroscopy (molecular information) and X-ray fluorescence spectroscopy (elemental information) following pigments could be identified: ultramarine (Na 8-10Al 6Si 6O 24S 2-4), azurite (2CuCO 3·Cu(OH) 2), caput mortuum (Fe 2O 3), vermilion (HgS), orpiment (As 2S 3) and lead white (2PbCO 3·Pb(OH) 2). Moreover, two synthetic red pigments, PR4 and PR176, and a degradation product, gypsum (CaSO 4·2H 2O), were present in the manuscript. To establish the origin of the modern materials UV-fluorescence photography was used. Infrared reflectography (IRR) was applied to visualise the underdrawing of the investigated folios.

Navigating manuscript assessment: The new practitioner's guide to primary literature peer review.

PubMed

Smith, Devlin V; Stokes, Laura B; Marx, Kayleigh; Aitken, Samuel L

2018-01-01

For pharmacists, the first years after graduation are spent developing their knowledge base, advancing as a practitioner, and honing their abilities as healthcare providers and drug information experts. New practitioners encounter many challenges during this time, which for many include publishing original research or reviewing manuscripts for colleagues and medical journals. Inexperience navigating the publication process, from submission to receipt of (and response to) peer review commentary, is often cited as a major barrier to timely publication of resident and new practitioner research. Serving as a peer reviewer in turn provides the new practitioner with insight on this process and can be an enlightening experience used to garner confidence in subsequently submitting their own formal manuscripts. A number of publications describing steps for peer review are available, however, many of these articles address more experienced reviewers or critique the peer review process itself. No definitive resource exists for new pharmacy practitioners interested in developing their peer review skills. The information presented in this summative guide should be used in conjunction with practice opportunities to help new practitioners develop proficiency at peer review.

A light on medical practice in 19th-century Canada: the medical manuscripts of Dr. John Mackieson of Charlottetown

PubMed Central

Shephard, D A

1998-01-01

During his long career as a physician in Charlottetown, Dr. John Mackieson (1795-1885) compiled 4 medical manuscripts: 2 sets of case records, a synopsis of the medical conditions that were common in his day and a formulary. As primary sources, these documents provide information about medicine in 19th-century Canada and augment our knowledge of the problems of medical practice in that era. They illustrate aspects of the work of Dr. Mackieson, a generalist with interests in surgery and obstetrics, and they facilitate an understanding of the rationale underlying the treatments that he and his contemporaries used. Although 150 years old, the case records can be appreciated for their relevance to the art of medicine. Two excerpts from the case records, presented in this article, provide a sense of Dr. Mackieson's writings and introduce a discussion on the significance of these manuscripts in relation to the ideas on disease and treatment that governed medical practice, both in Prince Edward Island and elsewhere in Canada, in the 19th century. PMID:9724982

Frank Parsons on Interests

ERIC Educational Resources Information Center

Briddick, William C.

2009-01-01

In addition to Frank Parsons' posthumous publications a third manuscript remained unpublished. The manuscript can be classified as part of the success literature so prominent in Parsons' era. Within the manuscript is a chapter dealing with interests. Progress in recent years has further defined and provided a comprehensive theoretical overview of…

Registration status and methodological reporting of randomized controlled trials in obesity research: A review.

PubMed

Byrne, Jillian L S; Yee, Tamara; O'Connor, Kathleen; Dyson, Michele P; Ball, Geoff D C

2017-04-01

To assess registration and reporting details of randomized controlled trials (RCTs) published from 2011 to 2016 across four obesity journals. All issues from four leading obesity journals were searched systematically for RCTs from January 2011 to June 2016. Data on registration status were extracted from manuscripts, online trial registries, and a trial database; corresponding authors were contacted for registration details, when necessary. The methodological reporting of RCTs was assessed on specific criteria from the Consolidated Standards of Reporting Trials. A total of 223 RCTs were reviewed. Three-quarters (n = 170) were registered publicly; 94 (55.3%) reported registration details in the manuscript, and 82 (48.2%) were registered prospectively. Newer RCTs were more likely to be registered prospectively than older RCTs (2014-2016: 57.3% vs. 2011-2013: 39.2%; c 2  = 5.5, P = 0.02). Assessment on the Consolidated Standards of Reporting Trials demonstrated that less than half of all studies reported data collection dates (n = 108; 48.4%) or included "randomized trial" in the title (n = 89; 39.9%). The methodological reporting of RCTs published in obesity journals is suboptimal, despite current guidelines and policies. To complement existing standards, editorial boards should incorporate mandatory fields within the online manuscript submission process to enhance the quality, transparency, and comprehensiveness of reporting RCTs in obesity journals. © 2017 The Obesity Society.

Electronic Preprints

NASA Astrophysics Data System (ADS)

Hanisch, R.

1999-12-01

Despite the tremendous advances in electronic publications and the increasing rapidity with which papers are now moving from acceptance into ``print,'' preprints continue to be an important mode of communication within the astronomy community. The Los Alamos e-preprint service, astro-ph, provides for rapid and cost-free (to authors and readers) dissemination of manuscripts. As the use of astro-ph has increased the number of paper preprints in circulation to libraries has decreased, and institutional preprint series appear to be waning. It is unfortunate, however, that astro-ph does not function in collaboration with the refereed publications. For example, there is no systematic tracking of manuscripts from preprint to their final, published form, and as a centralized archive it is difficult to distribute the tracking and maintenance functions. It retains documents that have been superseded or have become obsolete. We are currently developing a distributed preprint and document management system which can support both distributed collections of preprints (e.g., traditional institutional preprint series), can link to the LANL collections, can index other documents in the ``grey'' literature (observatory reports, telescope and instrument user's manuals, calls for proposals, etc.), and can function as a manuscript submission tool for the refereed journals. This system is being developed to work cooperatively with the refereed literature so that, for example, links to preprints are updated to links to the final published papers.

Disposable, Autonomic, Energy-Converting Ion Channel Sensor Materials

DTIC Science & Technology

2018-07-02

variant forms well-defined pores _____________________________ 26 4.2. Another pore-forming peptide, Ceratotoxin A, displays alamethicin-like activity ...bilayer recordings to examine the activity of these compounds on the single-pore level. We plan to use modified CtxA for targeted cell killing...strongly dependent on entropy of activation . Tethering is one strategy towards achieving this goal. A manuscript regarding this work is currently in

Bulgaria in the Current Geopolitical Situation

DTIC Science & Technology

2013-03-01

United States Army War College Class of 2013 DISTRIBUTION STATEMENT: A Approved for Public Release Distribution is Unlimited...manuscript is submitted in partial fulfillment of the requirements of the United States Army War College Diploma. The views expressed in this student...Defense, or the U.S. Government. The U.S. Army War College is accredited by the Commission on Higher Education of the Middle States Association of

["Is it an animal inside? "Melanie Klein's unpublished Don Juan Paper (1939)].

PubMed

Frank, Claudia

2008-01-01

Klein had been asked to contribute an article to the birthday number of the International Journal for Jones. The author outlines how she hurriedly wrote a text about Don Juan which, however, was rejected by the editor. Essential parts of it are presented in German translation. The manuscript is discussed in the context of Klein's published work as well as of the relevant contemporary literature. In Klein's view, Don Juan's genitality is determined by oral impulses and fears. By his manic acting out he attempts to ward off a depressive break-down. The paper ends with some reflections about why Klein--ontrary to her intention--failed to revise her manuscript for later publication.

[Modern view on etiology, pathogenesis and treatment of chronic pelvic pain syndrome].

PubMed

Vinarov, A Z

2017-04-01

The manuscript presents the analysis of scientific manuscripts written by Russian and foreign researchers devoted to chronic pelvic pain syndrome (CPPS) studies. In spite of widespread disease, there is no clear understanding on etiopathogenetic mechanisms of CPPS development and it is shown that besides infectious process cardiovascular, neuronal, locomotor, endocrine and immune systems are involved into pathological process of CPPS. Mentioned factors complicate the doctors task on effective therapy choice and stress the reasonability of complex approach to CPPS treatment. Combination drug containing affinity purified antibodies to endothelial NO-synthase and prostate-specific antigen in released-active form influences different pathogenetic mechanisms of CPPS and thereby reveals pronounced clinical efficacy.

[Medicine in the discovery of America].

PubMed

Gómez-Gallo, Alvaro

2003-01-01

The present manuscript aims to record some general aspects of science, and in particular from the beginning of anatomic studies, during the discovery of America. We mention by Vesalio, who was the best known anatomist of his time in the Western world. In addition this establishes the legal origins of the medical profession in Spain and America, with emphasis on distinct treatments, for example, those in Peru and Chile. This manuscript contains anecdotes and accounts of the time, the use of medicines of the day, and the relationship these had with the native medicine. Finally, medical department of Chile is described, together with a mention of the first hospitals of the Republic of Chile.

Journal of Wildlife Management guidelines

Treesearch

William M. Block; Frank R. Thompson; Dawn Hanseder; Allison Cox; Anna Knipps

2011-01-01

These Guidelines apply to all Journal of Wildlife Management (JWM, The Journal) submissions. Publishing a professional manuscript proceeds most smoothly if authors understand the policy, procedures, format, and style of the outlet to which they are submitting a manuscript. These instructions supersede all previous guidelines. Manuscripts that clearly deviate from this...

Preparing and Publishing a Scientific Manuscript

PubMed Central

Jirge, Padma R.

2017-01-01

Publishing original research in a peer-reviewed and indexed journal is an important milestone for a scientist or a clinician. It is an important parameter to assess academic achievements. However, technical and language barriers may prevent many enthusiasts from ever publishing. This review highlights the important preparatory steps for creating a good manuscript and the most widely used IMRaD (Introduction, Materials and Methods, Results, and Discussion) method for writing a good manuscript. It also provides a brief overview of the submission and review process of a manuscript for publishing in a biomedical journal. PMID:28479749

From course assignment paper to publishable manuscript.

PubMed

Rew, Lynn

2012-12-01

Both undergraduate and graduate nursing students are expected to write numerous papers in their educational programs; however, most of these papers are never published. Many students and faculty lack the skills needed to convert a course assignment paper to a publishable manuscript. The purpose of this article is to describe 10 steps that can transform a course assignment paper into a publishable manuscript. These steps include outlining, clarifying the topic, clearly stating the purpose, identifying an appropriate audience, revising with faculty's feedback, querying journal editors, revising to conform to journal's author guidelines, requesting and responding to peer feedback, and finally editing and proofreading prior to submitting the manuscript. Faculty members are encouraged to make writing assignments that students can then convert to publishable manuscripts. Such publications form an essential cornerstone of professional holistic nursing.

Appraisal of the papers of biomedical scientists and physicians for a medical archives.

PubMed Central

Anderson, P G

1985-01-01

Numerous medical libraries house archival collections. This article discusses criteria for selecting personal papers of biomedical scientists and physicians for a medical archives and defines key terms, such as appraisal, manuscripts, papers, records, and series. Appraisal focuses on both collection and series levels. Collection-level criteria include the significance of a scientist's career and the uniqueness, coverage, and accessibility of the manuscripts. Series frequently found among medically related manuscripts are enumerated and discussed. Types of organizational records and the desirability of accessioning them along with manuscripts are considered. Advantages of direct communication with creators of manuscripts are described. The initial appraisal process is not the last word: reevaluation of materials must take place during processing and can be resumed long afterwards. PMID:4052673

Submission of scientifically sound and ethical manuscripts to peer-reviewed journals - a reviewer's personal perspective on bioanalytical publications.

PubMed

Weng, Naidong

2012-11-01

In the pharmaceutical industry, bioanalysis is very dynamic and is probably one of the few fields of research covering the entire drug discovery, development and post-marketing process. Important decisions on drug safety can partially rely on bioanalytical data, which therefore can be subject to regulatory scrutiny. Bioanalytical scientists have historically contributed significant numbers of scientific manuscripts in many peer-reviewed analytical journals. All of these journals provide some high-level instructions, but they also leave sufficient flexibility for reviewers to perform independent critique and offer recommendations for each submitted manuscript. Reviewers play a pivotal role in the process of bioanalytical publication to ensure the publication of high-quality manuscripts in a timely fashion. Their efforts usually lead to improved manuscripts. However, it has to be a joint effort among authors, reviewers and editors to promote scientifically sound and ethically fair bioanalytical publications. Most of the submitted manuscripts were well written with only minor or moderate revisions required for further improvement. Nevertheless, there were small numbers of submitted manuscripts that did not meet the requirements for publications because of scientific or ethical deficiencies, which are discussed in this Letter to the Editor. Copyright © 2012 John Wiley & Sons, Ltd.

Drosophila learn efficient paths to a food source.

PubMed

Navawongse, Rapeechai; Choudhury, Deepak; Raczkowska, Marlena; Stewart, James Charles; Lim, Terrence; Rahman, Mashiur; Toh, Alicia Guek Geok; Wang, Zhiping; Claridge-Chang, Adam

2016-05-01

Elucidating the genetic, and neuronal bases for learned behavior is a central problem in neuroscience. A leading system for neurogenetic discovery is the vinegar fly Drosophila melanogaster; fly memory research has identified genes and circuits that mediate aversive and appetitive learning. However, methods to study adaptive food-seeking behavior in this animal have lagged decades behind rodent feeding analysis, largely due to the challenges presented by their small scale. There is currently no method to dynamically control flies' access to food. In rodents, protocols that use dynamic food delivery are a central element of experimental paradigms that date back to the influential work of Skinner. This method is still commonly used in the analysis of learning, memory, addiction, feeding, and many other subjects in experimental psychology. The difficulty of microscale food delivery means this is not a technique used in fly behavior. In the present manuscript we describe a microfluidic chip integrated with machine vision and automation to dynamically control defined liquid food presentations and sensory stimuli. Strikingly, repeated presentations of food at a fixed location produced improvements in path efficiency during food approach. This shows that improved path choice is a learned behavior. Active control of food availability using this microfluidic system is a valuable addition to the methods currently available for the analysis of learned feeding behavior in flies. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Twenty-First Annual Conference on Manual Control

NASA Technical Reports Server (NTRS)

Miller, R. A. (Compiler); Jagacinski, R. J. (Compiler)

1986-01-01

The proceedings of the entitled conference are presented. Twenty-nine manuscripts and eight abstracts pertaining to workload, attention and errors, controller evaluation, movement skills, coordination and decision making, display evaluation and human operator modeling and manual control.

Crude glycerol combustion: Particulate, acrolein, other volatile organic emissions

EPA Science Inventory

This STICS entry is for the presentation materials for a peer-reviewed journal manuscript entry by the same title (ORD-000108) previously entered an approved. A Product Description / Abstract for ORD-000108 was previously entered.

Hermann Hankel's "On the general theory of motion of fluids". An essay including an English translation of the complete Preisschrift from 1861

NASA Astrophysics Data System (ADS)

Villone, Barbara; Rampf, Cornelius

2017-12-01

The present is a companion paper to "A contemporary look at Hermann Hankel's 1861 pioneering work on Lagrangian fluid dynamics" by Frisch, Grimberg and Villone [Eur. Phys. J. H 42, 537-556 (2017)]. Here we present the English translation of the 1861 prize manuscript from Göttingen University "Zur allgemeinen Theorie der Bewegung der Flüssigkeiten" (On the general theory of the motion of the fluids) of Hermann Hankel (1839-1873), which was originally submitted in Latin and then translated into German by the Author for publication. We also provide the English translation of two important reports on the manuscript, one written by Bernhard Riemann and the other by Wilhelm Eduard Weber during the assessment process for the prize. Finally, we give a short biography of Hermann Hankel with his complete bibliography.

Writing Together to Get AHEAD: an interprofessional boot camp to support scholarly writing in the health professions

PubMed Central

von Isenburg, Megan; Lee, Linda S.; Oermann, Marilyn H.

2017-01-01

Background Writing for publication is an integral skill for both sharing research findings and career advancement, yet many faculty lack expertise, support, and time to author scholarly publications. Health professions educators identified writing as an area in which a new educators’ academy could offer support. Case Presentation To address this need, a writing task force was formed consisting of a librarian, a School of Medicine faculty member, and a School of Nursing faculty member. The task force launched two initiatives to motivate and support faculty writing and publication over two academic years. In the first year, a structured interprofessional “boot camp” consisting of a sequenced, modularized approach to manuscript completion was offered. In the second year, community building, in-person writing sessions, and incentives were added to the structured tasks. In year one, twenty participants enlisted in the boot camp, nine of whom completed a manuscript for submission by the end of the program. Qualitative feedback indicated potential improvements, which were put in place in the second program. In year two, twenty-eight participants enrolled, and eleven submitted thirteen manuscripts for publication by the end of the program. Conclusions Structured tasks, frequent deadlines, and professional editorial assistance were highly valued by participants. Time remains a barrier for faculty seeking to complete manuscripts. As experts in many facets of the publication process, librarians are well positioned to partner with others to facilitate faculty and staff development in writing. PMID:28377681

Expanding Group Peer Review: A Proposal for Medical Education Scholarship.

PubMed

Dumenco, Luba; Engle, Deborah L; Goodell, Kristen; Nagler, Alisa; Ovitsh, Robin K; Whicker, Shari A

2017-02-01

After participating in a group peer-review exercise at a workshop presented by Academic Medicine and MedEdPORTAL editors at the 2015 Association of American Medical Colleges Medical Education Meeting, the authors realized that the way their work group reviewed a manuscript was very different from the way by which they each would have reviewed the paper as an individual. Further, the group peer-review process yielded more robust feedback for the manuscript's authors than did the traditional individual peer-review process. This realization motivated the authors to reconvene and collaborate to write this Commentary to share their experience and propose the expanded use of group peer review in medical education scholarship.The authors consider the benefits of a peer-review process for reviewers, including learning how to improve their own manuscripts. They suggest that the benefits of a team review model may be similar to those of teamwork and team-based learning in medicine and medical education. They call for research to investigate this, to provide evidence to support group review, and to determine whether specific paper types would benefit most from team review (e.g., particularly complex manuscripts, those receiving widely disparate initial individual reviews). In addition, the authors propose ways in which a team-based approach to peer review could be expanded by journals and institutions. They believe that exploring the use of group peer review potentially could create a new methodology for skill development in research and scholarly writing and could enhance the quality of medical education scholarship.

Taxonomy for Education and Training in Clinical Neuropsychology: past, present, and future.

PubMed

Sperling, Scott A; Cimino, Cynthia R; Stricker, Nikki H; Heffelfinger, Amy K; Gess, Jennifer L; Osborn, Katie E; Roper, Brad L

2017-07-01

Historically, the clinical neuropsychology training community has not clearly or consistently defined education or training opportunities. The lack of consistency has limited students' and trainees' ability to accurately assess and compare the intensity of neuropsychology-specific training provided by programs. To address these issues and produce greater 'truth in advertising' across programs, CNS, with SCN's Education Advisory Committee (EAC), ADECN, AITCN, and APPCN constructed a specialty-specific taxonomy, namely, the Taxonomy for Education and Training in Clinical Neuropsychology. The taxonomy provides consensus in the description of training offered by doctoral, internship, and postdoctoral programs, as well as at the post-licensure stage. Although the CNS approved the taxonomy in February 2015, many programs have not adopted its language. Increased awareness of the taxonomy and the reasons behind its development and structure, as well as its potential benefits, are warranted. In 2016, a working group of clinical neuropsychologists from the EAC and APPCN, all authors of this manuscript, was created and tasked with disseminating information about the taxonomy. Group members held regular conference calls, leading to the generation of this manuscript. This manuscript is the primary byproduct of the working group. Its purpose is to (1) outline the history behind the development of the taxonomy, (2) detail its structure and utility, (3) address the expected impact of its adoption, and (4) call for its adoption across training programs. This manuscript outlines the development and structure of the clinical neuropsychology taxonomy and addresses the need for its adoption across training programs.

Newer regional analgesia interventions (fascial plane blocks) for breast surgeries: Review of literature.

PubMed

Garg, Rakesh; Bhan, Swati; Vig, Saurabh

2018-04-01

Surgical resection of the primary tumour with axillary dissection is one of the main modalities of breast cancer treatment. Regional blocks have been considered as one of the modalities for effective perioperative pain control. With the advent of ultrasound, newer interventions such as fascial plane blocks have been reported for perioperative analgesia in breast surgeries. Our aim is to review the literature for fascial plane blocks for analgesia in breast surgeries. The research question for initiating the review was 'What are the reported newer regional anaesthesia techniques (fascial plane blocks) for female patients undergoing breast surgery and their analgesic efficacy?.' The participants, intervention, comparisons, outcomes and study design were followed. Due to the paucity of similar studies and heterogeneity, the assessment of bias, systematic review or pooled analysis/meta-analysis was not feasible. Of the 989 manuscripts, the present review included 28 manuscripts inclusive of all types of published manuscripts. 15 manuscripts directly related to the administration of fascial plane blocks for breast surgery across all type of study designs and cases were reviewed for the utility of fascial plane blocks in breast surgeries. Interfascial blocks score over regional anaesthetic techniques such as paravertebral block as they have no risk of sympathetic blockade, intrathecal or epidural spread which may lead to haemodynamic instability and prolonged hospital stay. This review observed that no block effectively covers the whole of breast and axilla, thus a combination of blocks should be used depending on the site of incision and extent of surgical resection.

[The popular interpretation of strokes in ancient Galicia: the dragon myth].

PubMed

Pías-Peleteiro, Juan M; Blanco, Miguel; Arias, Manuel; Castillo, José

2011-05-01

The high prevalence and mortality of stroke has consequently brought about a wide presence of this pathology in the Galician pre-scientific folk medicine. A new interpretation of stroke, linked to the local tradition around the figure of Saint James the Apostle, is presented in this paper: stroke is considered to be the result of the evil influence of a dragon. In the Codex Calixtinus, a xii century manuscript containing various materials around the figure of Saint James, a dragon is also mentioned as an obstacle for the translation of the apostolic body. The third book of Codex Calixtinus containing the narration of the translation of the dead body of James the Greater from Palestine to its likely current location in Santiago de Compostela (Galicia, Spain), also holds the major written record of the dragon of the Pico Sacro mountain. The pagan symbol of the dragon has remained in the orally-transmitted Galician folk medicine as a direct cause for neurological diseases such as stroke. For the first time, in our knowledge, the symbol of a dragon as the magical explanation for cerebral vascular disease has been described. Moreover, this mythical explanation, found only in the Galician folk medicine, is strongly linked to the legend of the translation of James the Apostle to Galicia. Such a link supports the originality of the narration in the Codex Calixtinus as opposed to other versions of the apostolic translation which can be found in other manuscripts.

Standards for reporting qualitative research: a synthesis of recommendations.

PubMed

O'Brien, Bridget C; Harris, Ilene B; Beckman, Thomas J; Reed, Darcy A; Cook, David A

2014-09-01

Standards for reporting exist for many types of quantitative research, but currently none exist for the broad spectrum of qualitative research. The purpose of the present study was to formulate and define standards for reporting qualitative research while preserving the requisite flexibility to accommodate various paradigms, approaches, and methods. The authors identified guidelines, reporting standards, and critical appraisal criteria for qualitative research by searching PubMed, Web of Science, and Google through July 2013; reviewing the reference lists of retrieved sources; and contacting experts. Specifically, two authors reviewed a sample of sources to generate an initial set of items that were potentially important in reporting qualitative research. Through an iterative process of reviewing sources, modifying the set of items, and coding all sources for items, the authors prepared a near-final list of items and descriptions and sent this list to five external reviewers for feedback. The final items and descriptions included in the reporting standards reflect this feedback. The Standards for Reporting Qualitative Research (SRQR) consists of 21 items. The authors define and explain key elements of each item and provide examples from recently published articles to illustrate ways in which the standards can be met. The SRQR aims to improve the transparency of all aspects of qualitative research by providing clear standards for reporting qualitative research. These standards will assist authors during manuscript preparation, editors and reviewers in evaluating a manuscript for potential publication, and readers when critically appraising, applying, and synthesizing study findings.

Prevalence and types of misrepresentation of publication record by pathology residency applicants.

PubMed

Kaley, Jennifer Raible; Bornhorst, Joshua; Wiggins, Michael; Yared, Marwan

2013-07-01

Publication misrepresentation among residency applicants has been demonstrated in various specialties. This study examines the prevalence of publication misrepresentation among US-trained and non-US-trained pathology residency applicants. To determine the prevalence of publication misrepresentation in the pathology applicant pool at our institution, to compare the rates of misrepresentation among US-trained and non-US-trained applicants, and to compare results to published results from other medical specialties. All peer-reviewed journal articles reported on applications to our program in 2010 and 2011 were examined for veracity. Applications from current or past trainees and applications with unverifiable manuscripts were excluded. The type of misrepresentation and the country in which the applicant trained were recorded. Seven hundred applications were reviewed. Of 319 (46%) reported publications, 25 were from US graduates (8%) and 294 (92%) were from non-US graduates. Eighty-six applications were excluded owing to unverifiable manuscripts. Publication misrepresentations were found in 42 (18%) of the remaining 233 applications. The most common misrepresentations were omission of authors (69%), nonauthorship (14%), and self-promotion on the author list (12%). A significantly higher percentage of foreign medical graduates listed publications (P < .001). The misrepresentation rate by foreign graduates (19%) did not differ significantly from that of US-trained graduates (13%) (P = .45). Publication misrepresentation was present among pathology residency applicants. Similar rates were seen among US and non-US applicants. Percentages of misrepresentation among applicants to our pathology program and applicants to other medical specialties (18% and 17%, respectively) were comparable.

Top Ten Musings about Publishing Qualitative Manuscripts: Managing the Devil in the Details

ERIC Educational Resources Information Center

Palladino, John M.

2011-01-01

The purpose of this presentation was to engage in dialogue with editors of other qualitative journals and conference participants about the common roadblocks that hinder the publication possibilities for qualitative research studies. All audience participants were conference presenters and/or qualitative researchers, novice level and above. The…

Writing for the Ear: Strengthening Oral Style in Manuscript Speeches

ERIC Educational Resources Information Center

Bruss, Kristine

2012-01-01

Public speaking texts typically advise speakers to avoid using a manuscript. Speaking from a manuscript can limit eye contact, reduce expressiveness, and bore listeners. The ideal, rather, is to sound conversational. Conversational style is inclusive, suggesting that a speaker is ""of the people," united in understanding, values and purpose." If a…

Journal Reviewer Ratings: Issues of Particularistic Bias, Agreement, and Predictive Validity within the Manuscript Review Process

ERIC Educational Resources Information Center

Vecchio, Robert P.

2006-01-01

Reviewer evaluations and recommendations for 853 manuscript submissions, over a span of 4 years, are analyzed for evidence of particularistic bias, reviewer agreement, and predictive validity for forecasting a published manuscript's citation impact. Attributes of the submitters, their affiliated institutions, and the reviewers have little…

Analysis of Publication Decisions for "Journal of Research in Music Education" Manuscripts (2009-2014)

ERIC Educational Resources Information Center

Sims, Wendy L.; Lordo, Jackie; Phelps, Cynthia Williams

2016-01-01

The primary purpose of this study was to investigate characteristics of manuscripts submitted to the "Journal of Research in Music Education" (JRME) representing various research methodologies. A database was compiled comprising all manuscripts that received a publication decision from February 2009 through March 2014 (N = 506). Only…

Roving the Pacific: Pacific Manuscripts Bureau Microfilming in the Pacific Islands.

ERIC Educational Resources Information Center

Maidment, Ewan

1998-01-01

Provides an overview of microfilming by the Pacific Manuscripts Bureau (PMB), a non-profit organization established in 1968 to identify and preserve archives, manuscripts, and rare printed documents relating to the South Pacific Islands. Describes a 1997 PMB microfilming expedition to Papua New Guinea and the Solomon Islands. (PEN)

Biochemia Medica has started using the CrossCheck plagiarism detection software powered by iThenticate

PubMed Central

Šupak-Smolčić, Vesna; Šimundić, Ana-Maria

2013-01-01

In February 2013, Biochemia Medica has joined CrossRef, which enabled us to implement CrossCheck plagiarism detection service. Therefore, all manuscript submitted to Biochemia Medica are now first assigned to Research integrity editor (RIE), before sending the manuscript for peer-review. RIE submits the text to CrossCheck analysis and is responsible for reviewing the results of the text similarity analysis. Based on the CrossCheck analysis results, RIE subsequently provides a recommendation to the Editor-in-chief (EIC) on whether the manuscript should be forwarded to peer-review, corrected for suspected parts prior to peer-review or immediately rejected. Final decision on the manuscript is, however, with the EIC. We hope that our new policy and manuscript processing algorithm will help us to further increase the overall quality of our Journal. PMID:23894858

P-Hacking: A Wake-Up Call for the Scientific Community.

PubMed

Raj, A Thirumal; Patil, Shankargouda; Sarode, Sachin; Salameh, Ziad

2017-10-25

P-hacking or data dredging involves manipulation of the research data in order to obtain a statistically significant result. The reasons behind P-hacking and the consequences of the same are discussed in the present manuscript.

Metrics for Original Research Articles in the AJR: From First Submission to Final Publication.

PubMed

Rosenkrantz, Andrew B; Harisinghani, Mukesh

2015-06-01

The objective of our study was to evaluate manuscript metrics pertaining to AJR submissions, assessing the pathway from manuscript submission to publication, including the reviewer allocation time, decisions rendered, timing of decisions rendered, and time to publication. Six hundred ninety-six unsolicited Original Research manuscripts submitted to the AJR between July 1, 2012, and December 21, 2012, were included in this retrospective analysis. Metrics pertaining to manuscripts' decision status and associated timelines were extracted by journal editorial staff and assessed using standard summary statistics. For new submissions, decisions rendered were as follows: Accept, 0.3%; Minor Revision, 8.5%; Major Revision, 19.7%; Reject, 65.1%; and Reject Without Review, 6.5%. For first and second resubmissions, 40.0-55.2% of manuscripts representing a Major Revision and 91.5-94.7% of manuscripts representing a Minor Revision were accepted; 100% of manuscripts undergoing a third resubmission were accepted; 98.3% and 84.7% of manuscripts receiving at first submission a decision of Minor Revision and Major Revision, respectively, ultimately achieved acceptance. The time (mean ± SD) to review a new submission was 30.5 ± 43.1 days (Accept), 42.7 ± 27.4 days (Minor Revision), 39.4 ± 17.6 days (Major Revision), and 40.2 ± 20.3 days (Reject) and decreased with each subsequent resubmission to 6.3 ± 6.3 days (Accept) for third resubmissions. The mean days for authors to submit a first resubmission was 21.1 ± 15.3 days (Minor Revision) and 73.7 ± 65.1 days (Major Revision) and decreased with each subsequent resubmission to 9.8 ± 11.3 days (Minor Revision) and 27.0 ± 0.0 days (Major Revision) for third resubmissions. The mean time from acceptance to publication was 242.5 ± 47.5 days. The observed metrics may provide valuable insights for authors and for AJR editorial staff in ongoing efforts to shorten turnaround times from manuscript submission to publication.

The current situation and challenges of screening for and treating hepatitis B in sub-Saharan Africa.

PubMed

Béguelin, Charles; Fall, Fatou; Seydi, Moussa; Wandeler, Gilles

2018-05-16

Hepatitis B virus (HBV) infection is the most important cause of hepatocellular carcinoma in sub-Saharan Africa (SSA). Although the tools to curb the epidemic are known, only a minority of HBV-infected persons are currently diagnosed and treated. Areas covered: We discuss HBV epidemiological trends in SSA, describe important determinants of its natural history, and summarize current knowledge on the continuum of HBV care. Using the results of a systematic review of the literature, we describe the proportion of patients with liver fibrosis at presentation for care. Throughout the manuscript, we highlight major research gaps and explore potential ways to improve uptake of HBV testing, evaluation of liver disease, access to antiviral therapy and monitoring of complications. Expert commentary: Less than 1% of HBV-infected individuals are diagnosed in SSA, despite the availability of rapid tests with good diagnostic accuracy. Up to 15% of individuals enter care with liver cirrhosis, a clear indication for antiviral therapy. Although the proportion of patients eligible for immediate antiviral treatment is generally below 20%, there are few published data from prospective cohort studies. The incidence of hepatocellular carcinoma could be reduced with improved access to antiviral therapy.

Vulnerability to cavitation of central California Arctostaphylos (Ericaceae): a new analysis.

PubMed

Jacobsen, Anna L; Brandon Pratt, R

2013-02-01

A recent study, 'Influence of summer marine fog and low cloud stratus on water relations of evergreen woody shrubs (Arctostaphylos: Ericaceae) in the chaparral of central California' by M. Vasey, M.E. Loik, and V.T. Parker (2012, Oecologia, in press), presented data on the vulnerability to cavitation of eight Arctostaphylos species. We reanalyzed the vulnerability data presented in this manuscript using a different statistical model and have arrived at different conclusions than those reported previously. We suggest that regional differences have not lead to differentiation in cavitation resistance among populations of an Arctostaphylos species and, contrary to the conclusions of Vasey et al., the xylem of maritime species appears to be "overbuilt" for their current environment and do not appear to be especially vulnerable to water stress. Importantly, data on vulnerability to cavitation are limited for Arctostaphylos species from these sites. More specifically, treatment factors of site and region were not replicated and therefore conclusions drawn from these data are necessarily limited.

Air core notch-coil magnet with variable geometry for fast-field-cycling NMR.

PubMed

Kruber, S; Farrher, G D; Anoardo, E

2015-10-01

In this manuscript we present details on the optimization, construction and performance of a wide-bore (71 mm) α-helical-cut notch-coil magnet with variable geometry for fast-field-cycling NMR. In addition to the usual requirements for this kind of magnets (high field-to-power ratio, good magnetic field homogeneity, low inductance and resistance values) a tunable homogeneity and a more uniform heat dissipation along the magnet body are considered. The presented magnet consists of only one machined metallic cylinder combined with two external movable pieces. The optimal configuration is calculated through an evaluation of the magnetic flux density within the entire volume of interest. The magnet has a field-to-current constant of 0.728 mT/A, allowing to switch from zero to 0.125 T in less than 3 ms without energy storage assistance. For a cylindrical sample volume of 35 cm(3) the effective magnet homogeneity is lower than 130 ppm. Copyright © 2015 Elsevier Inc. All rights reserved.

Note: Expanding the bandwidth of the ultra-low current amplifier using an artificial negative capacitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Kai, E-mail: kaixie@mail.xidian.edu.cn; Liu, Yan; Li, XiaoPing

2016-04-15

The bandwidth and low noise characteristics are often contradictory in ultra-low current amplifier, because an inevitable parasitic capacitance is paralleled with the high value feedback resistor. In order to expand the amplifier’s bandwidth, a novel approach was proposed by introducing an artificial negative capacitor to cancel the parasitic capacitance. The theory of the negative capacitance and the performance of the improved amplifier circuit with the negative capacitor are presented in this manuscript. The test was conducted by modifying an ultra-low current amplifier with a trans-impedance gain of 50 GΩ. The results show that the maximum bandwidth was expanded from 18.7more » Hz to 3.3 kHz with more than 150 times of increase when the parasitic capacitance (∼0.17 pF) was cancelled. Meanwhile, the rise time decreased from 18.7 ms to 0.26 ms with no overshot. Any desired bandwidth or rise time within these ranges can be obtained by adjusting the ratio of cancellation of the parasitic and negative capacitance. This approach is especially suitable for the demand of rapid response to weak current, such as transient ion-beam detector, mass spectrometry analysis, and fast scanning microscope.« less

Pseudomonas aeruginosa ventilator-associated pneumonia management

PubMed Central

Ramírez-Estrada, Sergio; Borgatta, Bárbara; Rello, Jordi

2016-01-01

Ventilator-associated pneumonia is the most common infection in intensive care unit patients associated with high morbidity rates and elevated economic costs; Pseudomonas aeruginosa is one of the most frequent bacteria linked with this entity, with a high attributable mortality despite adequate treatment that is increased in the presence of multiresistant strains, a situation that is becoming more common in intensive care units. In this manuscript, we review the current management of ventilator-associated pneumonia due to P. aeruginosa, the most recent antipseudomonal agents, and new adjunctive therapies that are shifting the way we treat these infections. We support early initiation of broad-spectrum antipseudomonal antibiotics in present, followed by culture-guided monotherapy de-escalation when susceptibilities are available. Future management should be directed at blocking virulence; the role of alternative strategies such as new antibiotics, nebulized treatments, and vaccines is promising. PMID:26855594

The Fabrication Technique and Property Analysis of Racetrack-Type High Temperature Superconducting Magnet for High Power Motor

NASA Astrophysics Data System (ADS)

Xie, S. F.; Wang, Y.; Wang, D. Y.; Zhang, X. J.; Zhao, B.; Zhang, Y. Y.; Li, L.; Li, Y. N.; Chen, P. M.

2013-03-01

The superconducting motor is now the focus of the research on the application of high temperature superconducting (HTS) materials. In this manuscript, we mainly introduce the recent progress on the fabrication technique and property research of the superconducting motor magnet in Luoyang Ship Material Research Institute (LSMRI) in China, including the materials, the winding and impregnation technique, and property measurement of magnet. Several techniques and devices were developed to manufacture the magnet, including the technique of insulation and thermal conduction, the device for winding the racetrack-type magnet, etc. At last, the superconducting magnet used for the MW class motor were successfully developed, which is the largest superconducting motor magnet in china at present. The critical current of the superconducting magnet exceeds the design value (90 A at 30 K).

Reanalysis of Mariner 9 UV spectrometer data for ozone, cloud, and dust abundances, and their interaction over climate timescales

NASA Technical Reports Server (NTRS)

Lindner, Bernhard Lee

1992-01-01

Research activities to date are discussed. Selected Mariner 9 UV spectra were obtained. Radiative transfer models were updated and then exercised to simulate spectra. Simulated and observed spectra compare favorably. It is noted that large amounts of ozone are currently not retrieved with reflectance spectroscopy, raising large doubts about earlier published ozone abundances. As these published abundances have been used as a benchmark for all theoretical photochemical models of Mars, this deserves further exploration. Three manuscripts were published, and one is in review. Papers were presented and published at three conferences, and are planned for five more conferences in the next six months. The research plan for the next reporting period is discussed and involves continuing studies of reflectance spectroscopy, further examination of Mariner 9 data, and climate change studies of ozone.

Low Temperature Characterization of Ceramic and Film Power Capacitors

NASA Technical Reports Server (NTRS)

Hammoud, Ahmad; Overton, Eric

1996-01-01

Among the key requirements for advanced electronic systems is the ability to withstand harsh environments while maintaining reliable and efficient operation. Exposures to low temperature as well as high temperature constitute such stresses. Applications where low temperatures are encountered include deep space missions, medical imaging equipment, and cryogenic instrumentation. Efforts were taken to design and develop power capacitors capable of wide temperature operation. In this work, ceramic and film power capacitors were developed and characterized as a function of temperature from 20 C to -185 C in terms of their dielectric properties. These properties included capacitance stability and dielectric loss in the frequency range of 50 Hz to 100 kHz. DC leakage current measurements were also performed on the capacitors. The manuscript presents the results that indicate good operational characteristic behavior and stability of the components tested at low temperatures.

Pseudomonas aeruginosa ventilator-associated pneumonia management.

PubMed

Ramírez-Estrada, Sergio; Borgatta, Bárbara; Rello, Jordi

2016-01-01

Ventilator-associated pneumonia is the most common infection in intensive care unit patients associated with high morbidity rates and elevated economic costs; Pseudomonas aeruginosa is one of the most frequent bacteria linked with this entity, with a high attributable mortality despite adequate treatment that is increased in the presence of multiresistant strains, a situation that is becoming more common in intensive care units. In this manuscript, we review the current management of ventilator-associated pneumonia due to P. aeruginosa, the most recent antipseudomonal agents, and new adjunctive therapies that are shifting the way we treat these infections. We support early initiation of broad-spectrum antipseudomonal antibiotics in present, followed by culture-guided monotherapy de-escalation when susceptibilities are available. Future management should be directed at blocking virulence; the role of alternative strategies such as new antibiotics, nebulized treatments, and vaccines is promising.

TH-C-204-03: Writing Good Scientific Papers and Responding to Critiques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goodsitt, M.

In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is “to continue the Journal’s tradition of publishing the very best science that propels ourmore » discipline forward and improves our contribution to patient care.” More concretely, the Journal should be the preeminent forum for exchange of cutting edge medical physics science. We seek to identify the best contributions in (a) high impact clinical physics innovations; (b) clinical translation and validation of basic science innovations; and (c) cutting edge basic science developments with potential for patient care improvements. Among the challenges and opportunities, we face are: electronic-only and open access publishing; competition from new radiological science journals; trends towards more interactive, social-media based scientific communities; and diversification of the medical physics research, authorship, and readership domains, including clinical applications quite foreign to core ABR clinical competencies. Recently implemented and ongoing initiatives include: Revised Table of Contents (TOC) and more contemporary topical submission categories Structured review template in HTML format Comprehensive hierarchical taxonomy for identifying reviewer expertise Formal process for soliciting high quality and impact Review and Vision 20/20 Articles We have recruited four Review Article Co-editors: John Rowlands and Ingrid Reiser (imaging physics) and Joao Seco and Tim Zhu (therapy physics). The Co-Editors will identify timely topics and solicit high profile authors to submit review manuscripts. To submit an article, authors will need to work with an assigned Co-Editor to develop a mutually acceptable outline and abstract. 5) A new and exciting class of articles: Medical Physics Dataset Articles (MPDAs) MPDAs describe scientifically or clinically valuable open-access datasets with high potential for contributing to the research of medical physicists working on related problems. In contrast to Research Articles, MPDAs should not include hypothesis testing; or data analyses supporting generalizable conclusions. The publically accessible dataset must be permanently archived before the MPDA can be published. This initiative is being led by Joe Deasy. Update on new publisher transition: The transition of AAPM scientific publishing operations to a major publishing house is a major opportunity to expand Medical Physics readership and its scholarly impact. The advantages include: (a) common manuscript management and web hosting platforms for Medical Physics and its sister journal, JACMP; (b) greater than 4-fold expansion of subscribing institutions; and (c) resources to mount data-driven, highly targeted marketing campaigns to enhance citation and download rates. A transition update of this epochal development, which has only begun as of this writing (3/31/16), will be given. Improving manuscript quality via structured reviews, enhanced scientific category taxonomy, and outreach: Shiva Das, Therapy Physics Editor Medical Physics is committed to continuous improvement with the ultimate goal of improving the potential impact of accepted manuscripts. In order to do so, Medical Physics must be able to tap into important/emerging areas and be able to select high quality contributions consistently via discerning reviews. Improving the quality of reviews is crucial to selecting high quality manuscripts and also to improving manuscript impact via feedback in the review process. With this in mind, Medical Physics is in the process of: (a) fostering outreach to important areas that are currently underrepresented in Medical Physics; (b) implementing a structured template review form; and (c) implementing a comprehensive scientific category taxonomy to identify reviewers who are best suited to an article. Outreach efforts have begun to various scientific areas. Strategies to increase submissions from these areas will be discussed. As a consequence of this effort, a special issue on particle therapy is under development. A review template was implemented in late 2014 on a limited test basis. Based on reviewer feedback, the template was restructured and shortened to capture essential review elements. The restructured template is due to be released shortly. The new scientific category taxonomy is in the process of being deployed to reviewers and associate editors. Salient aspects of the structured review template and scientific category taxonomy will be discussed in this talk. Writing good scientific papers and responding to critiques: Mitch Goodsitt, Imaging Physics Editor The essential components of the abstract, introduction, methods, discussion and conclusion sections of manuscripts, as well as the desired writing style and style of the figures and tables will be reviewed. Publishable Medical Physics manuscripts must include clear and concise statements of the novelty and clinical and/or scientific importance of the authors’ work. Examples of novelty include: new technical solution to an important clinical problem; new generalizable knowledge; and first demonstration that an existing engineering solution solves a clinical problem. Please note that we encourage authors of recently published conference proceedings (e.g., SPIE, IEEE) papers on novel medical physics related work to submit more substantial versions of that work to our journal. All submissions must include: sufficient background information and rationale; enough detail for others to reproduce the authors’ work; sufficient statistical analysis to refute or validate the authors’ hypotheses; a description of how the present work compares to, is distinct from, and improves upon others’ work; and sections devoted to the limitations of the study and future directions. Writing should be polished. Poor wording, grammar and composition frustrate the review process. Our journal does not have copyeditors for revising manuscripts. When authors receive critiques from the referees and associate editor, the authors should provide a detailed point-by-point response to each comment. The authors’ rebuttal should include the text of the original criticism, the authors’ response, and a pasted copy of the modified text along with the line numbers in the revised article. The new text should be highlighted in a different font color in the revised submission. Following these recommendations will improve submissions and facilitate the review process.« less

Reviewing for "Beyond Behavior": An Editor's Guide for Submitting a Comprehensive and Meaningful Review

ERIC Educational Resources Information Center

Mooney, Paul; Ryan, Joseph B.

2018-01-01

Reviewing manuscripts is an integral part of the publication process. Unfortunately, few scholars receive training in this skill. This article provides an overview of what it takes to conduct a quality review of a manuscript submission for a practitioner journal. The editors describe the manuscript types published by "Beyond Behavior"…

From Rejected to Accepted: Part 1--Strategies for Revising and Resubmitting a Manuscript

ERIC Educational Resources Information Center

Stivers, Jan; Cramer, Sharon

2017-01-01

Manuscript rejection is a fact of life for academics, and should be seen as just one step in a process of revision and resubmission that typically results in publication. This two-part article offers suggestions to help authors take action on their rejected manuscripts, including analyzing reviewer feedback, revising judiciously, and making…

Development of a Novel Segmental Bone Defect Construct

DTIC Science & Technology

2017-10-01

differentiation, and biological activity of both primary synoviocytes and bone marrow derived connective tissue progenitor cells. During the majority of...halted activity on the project from the dates of 31 May 2016 to 13 July 2017. However, the project is on schedule with the current, revised project...supervised all project activities and participated in the preparation of the manuscript that was produced during this reporting period. Name: Dr

Magnetic Resonance Spectroscopy: An Objective Modality to Identify the Pathology of Breast Neoplasms

DTIC Science & Technology

1999-05-01

Zealand Journal or Surgery Appendix IV: Attached Manuscript published in Life Sciences Appendix V: Attached Figures 1-13 Appendix VI: Attached Tables 1... early diagnosis and effective management. The triage of mammography, clinical examination and fine needle aspiration biopsy is currently used to...identify early breast cancers. Magnetic resonance imaging (MRI) has now been added to select women with breast abnormalities requiring biopsy. However

A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

DTIC Science & Technology

2013-09-01

implemented to significantly decrease the IIR system response time, especially when artifacts were highly reproducible in consecutive stimulation...cycles. The proposed system architecture was hardware- implemented on a field- programmable gate array (FPGA) and tested using two sets of prerecorded...its FPGA implementation and testing with prerecorded neural datasets are reported in a manuscript currently in press with the IEEE Transactions on

A Methodology for Implementing the Department of Defense’s Current In-Sourcing Policy

DTIC Science & Technology

2011-01-01

Riposo, Irv Blickstein, Stephanie Young , Geoffrey McGovern, Brian McInnis Prepared for the United States Navy Approved for public release; distribution... Keating for their thoughtful reviews of the draft manuscript. xv Abbreviations 2009 NDAA Duncan Hunter National Defense Authorization Act for Fiscal...some action by contract, policy, regulation, authorization, order, or otherwise; • determine, protect, and advance United States economic , political

A compendium of forest growth and yield simulators for the Pacific coast states

Treesearch

Martin W. Ritchie

1999-01-01

This manuscript provides information needed for the user to access current information about forest growth and yield simulators. Ultimately, the best source of information for any simulator is the user’s guide and the sage advice of those who built the simulator. In some instances, these people are easy to find and are willing to provide all the support for the program...

The diagnosis, evaluation and treatment of acute and recurrent pediatric urinary tract infections.

PubMed

Becknell, Brian; Schober, Megan; Korbel, Lindsey; Spencer, John David

2015-01-01

Urinary tract infection (UTI) is one of the most common bacterial infections encountered by pediatricians. Currently, the diagnosis and management of acute UTI and recurrent UTI in children remain controversial. Recently published guidelines and large clinical trials have attempted to clarify UTI diagnostic and management strategies. In this manuscript, we review the diagnosis and management of acute and recurrent UTI in the pediatric population.

Electronics: Mott Transistor: Fundamental Studies and Device Operation Mechanisms

DTIC Science & Technology

2016-03-21

display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. Harvard University Office for Sponsored Programs...including journal references , in the following categories: (b) Papers published in non-peer-reviewed journals (N/A for none) 03/21/2016 03/21/2016 03...limited kinetics of electron doping in correlated oxides, Applied Physics Letters (07 2015) TOTAL: 1 Books Number of Manuscripts: Patents Submitted

The Infectious Pathogenesis of Prostate Cancer

DTIC Science & Technology

2009-03-01

prostate cancer. A manuscript of these data is currently under peer-review. Propionibacterium acnes is a bacterium which has previously been...completed an evaluation of the tissue specimens for evidence of P acnes with collaborators at the University of Orebro, Sweden using a FISH assay...Almost 20 percent of men had evidence of P acnes infection in the tissue. We are now undertaking statistical analyses to evaluate the association of P

Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing

PubMed Central

Gross, Neil D.; Holsinger, F. Christopher; Magnuson, J. Scott; Duvvuri, Umamaheswar; Genden, Eric M.; Ghanem, Tamer AH.; Yaremchuk, Kathleen L.; Goldenberg, David; Miller, Matthew C.; Moore, Eric J.; Morris, Luc GT.; Netterville, James; Weinstein, Gregory S.; Richmon, Jeremy

2016-01-01

Training and credentialing for robotic surgery in otolaryngology - head and neck surgery is currently not standardized, but rather relies heavily on industry guidance. This manuscript represents a comprehensive review of this increasingly important topic and outlines clear recommendations to better standardize the practice. The recommendations provided can be used as a reference by individuals and institutions alike, and are expected to evolve over time. PMID:26950771

Pediatric post-marketing safety systems in North America: assessment of the current status.

PubMed

McMahon, Ann W; Wharton, Gerold T; Bonnel, Renan; DeCelle, Mary; Swank, Kimberley; Testoni, Daniela; Cope, Judith U; Smith, Phillip Brian; Wu, Eileen; Murphy, Mary Dianne

2015-08-01

It is critical to have pediatric post-marketing safety systems that contain enough clinical and epidemiological detail to draw regulatory, public health, and clinical conclusions. The pediatric safety surveillance workshop (PSSW), coordinated by the Food and Drug Administration (FDA), identified these pediatric systems as of 2010. This manuscript aims to update the information from the PSSW and look critically at the systems currently in use. We reviewed North American pediatric post-marketing safety systems such as databases, networks, and research consortiums found in peer-reviewed journals and other online sources. We detail clinical examples from three systems that FDA used to assess pediatric medical product safety. Of the 59 systems reviewed for pediatric content, only nine were pediatric-focused and met the inclusion criteria. Brief descriptions are provided for these nine. The strengths and weaknesses of three systems (two of the nine pediatric-focused and one including both children and adults) are illustrated with clinical examples. Systems reviewed in this manuscript have strengths such as clinical detail, a large enough sample size to capture rare adverse events, and/or a patient denominator internal to the database. Few systems include all of these attributes. Pediatric drug safety would be better informed by utilizing multiple systems to take advantage of their individual characteristics. Copyright © 2015 John Wiley & Sons, Ltd.

Publication Bias in Kienbock's Disease: A Systematic Review

PubMed Central

Squitieri, Lee; Petruska, Elizabeth; Chung, Kevin C

2015-01-01

Purpose Kienbock's disease is considered a “rare disease” and currently affects less than 200,000 people in the U.S. Given the inherent challenges associated with researching rare diseases, the intense effort in hand surgery to treat this uncommon disorder may be susceptible to publication bias in which positive outcomes are preferentially published. The specific aim of this project is to conduct a systematic review of the literature with the hypothesis that publication bias is present for the treatment of Kienbock's disease. Methods We conducted a systematic review of all available abstracts associated with published manuscripts (English and non-English) and abstracts accepted to the 1992-2004 American Society for Surgery of the Hand (ASSH) annual meetings. Data collection included various study characteristics, direction of outcome (positive, neutral/negative), complication rates, mean follow-up time, time to publication, and length of patient enrollment. Results Our study included 175 (124 English, 51 non-English) published Kienbock's manuscripts and 14 Kienbock's abstracts from the 1992-2004 annual ASSH meetings. Abstracts from published manuscripts were associated with a 53% positive outcome rate, which is lower than the 74% positive outcome rate found among other surgical disorders. Over the past 40 years, studies have become more positive (36% to 68%, p = 0.007) and are more likely to incorporate statistical analysis testing (0% to 55%, p <0.001). Of the 14 abstracts accepted to ASSH, 11 (79%) were published in peer-reviewed journals. Ten of the 14 accepted abstracts (71%) were considered positive, and there was no significant difference in publication rate between studies with positive (n = 10) and non-positive (n = 4) outcomes (p = 1.000). Conclusions The acceptance rate for negative outcomes studies regarding Kienbock's disease is higher than for other surgical disorders. This may indicate a relative decrease in positive outcome bias among published Kienbock's studies compared to other surgical disorders. However, the increasing positive outcome rate for published Kienbock's studies over time may suggest a trend of increasing publication bias among journals toward Kienbock's studies. PMID:20193856

[Pharmaceutical advice concerning different pharmaceutical dosage forms].

PubMed

Szakonyi, Gergely; Zelkó, Romána

2010-01-01

The present paper summarizes the commonly applied types of drug uptake and the pharmacists' advice concerning a certain dosage form. The manuscript also deals with the modified release dosage forms and their abbreviations in the name of the marketing authorized products.

New Frontiers in Psychiatric Technology.

ERIC Educational Resources Information Center

Fuzessery, Zoltan, Ed.

The second annual educational workshop concerned utilization of psychiatric technicians for technical service to allied professions. Manuscripts are included for the following presentations: (1) "Brief History of Colorado Psychiatric Technicians Association" by Francis L. Hedges, (2) "Hominology--The Approach to the Whole Man"…

Peroxiredoxin 1 Stimulates Secretion of Pro-Inflammatory Cytokines by Binding to Toll-like Receptor 4

PubMed Central

Riddell, Jonah R.; Wang, Xiang-Yang; Minderman, Hans; Gollnick, Sandra O.

2010-01-01

Peroxiredoxin 1 (Prx1) is an antioxidant and molecular chaperone that can be secreted from tumor cells. Prx1 is over-expressed in many cancers and elevation of Prx1 is associated with poor clinical outcome. In the current study we demonstrate that incubation of Prx1 with thioglycollate (TG)-elicited murine macrophages or immature bone marrow derived dendritic cells resulted in Toll-like receptor 4 (TLR4) dependent secretion of TNF-α and IL-6 and dendritic cell maturation. Optimal secretion of cytokines in response to Prx1 was dependent upon serum and required CD14 and MD2. Binding of Prx1 to TG-macrophages occurred within minutes and resulted in TLR4 endocytosis. Prx1 interaction with TLR4 was independent of its peroxidase activity and appeared to be dependent upon its chaperone activity and ability to form decamers. Cytokine expression occurred via the TLR-MyD88 signaling pathway, which resulted in nuclear translocation and activation of NFκB. These findings suggest that Prx1 may act as danger signal similar to other TLR4 binding chaperone molecules such as HSP72. This is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (AAI), publisher of The JI, holds the copyright to this manuscript. This version of the manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the U.S. National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org. PMID:20018613

Shaping the Marketers of Tomorrow: An Analysis of 25 Years of Marketing Education Review

ERIC Educational Resources Information Center

Morrison, Stacey A.; Blair, Amanda J.; McMullan, Kylie L.; Flostrand, Andrew

2017-01-01

This article presents a bibliometric analysis of "Marketing Education Review" from its inception in 1990 until 2014. A brief history of the journal is presented and its content is analyzed. In total, 706 articles were studied in terms of their authorship, manuscript, and content characteristics. Descriptive statistics provide an overview…

Material for "Substrate temperature controls molecular orientation in two-component vapor- deposited glasses." Soft Matter, 2016, 12, 3265.

DOE Data Explorer

Jiang, Jing [Nanjing University; Walters, Diane M [University of Wisconsin-Madison; Zhou, Dongshan [Nanjing University; Ediger, Mark D [University of Wisconsin-Madison

2016-08-18

Data set for work presented in Jiang, J.; Walters, D. M.; Zhou, D.; Ediger, M. D. “Substrate Temperature Controls Molecular Orientation in Two -Component Vapor-deposited Glasses.” Soft Matt. 2016, 12, 3265. Includes all data presented in the manuscript as well as example raw data and analysis.

Literacy Research, Theory, and Practice: Views from Many Perspectives. Forty-First Yearbook of the National Reading Conference.

ERIC Educational Resources Information Center

Kinzer, Charles K., Ed.; Leu, Donald J., Ed.

The 43 manuscripts presented in this collection represent qualitative and quantitative studies, as well as papers that present literacy research, theory, and pedagogy. Papers in the collection include: "Family Uses of Literacy: A Critical Voice" (D. Madigan); "Intergenerational Literacy: Impact on the Development of the Storybook Reading Behaviors…

Analyzing the Relationships between Culture and Mentoring

ERIC Educational Resources Information Center

Kochan, Frances

2013-01-01

The purpose of this manuscript is to present a theoretical model of culture from which a conceptual framework has been built that can be used to conduct a cultural analysis. The paper presents definitions and components of culture and its role in our expanding global society. It then relates these to research findings related to the relationship…

Author-based journal selection system that helps authors save time in article submission.

PubMed

Ozturk, Onur; Ileri, Fatih

2018-01-01

Submission to journals takes a lot of time and format related submission requirements vary greatly from one journal to another. Lack of time and motivation in academia reduces scientific outputs and demotivates researchers. Author-based journal selection system (ABJSS) is a platform for pooling manuscripts conceived to minimize the time spent for manuscript submission and to increase scientific output. The system will provide two types of account: "Author" and "Journal Administrator". Each account type will have its own abilities and permissions. The ABJJS system is an ongoing project that will be designed in cooperation with IT experts and academicians and it will be presented to the scientific world as soon as it secures sufficient support.

How do I write a scientific article?-A personal perspective.

PubMed

Lippi, Giuseppe

2017-10-01

Scientific writing is not an easy task. Although there is no single and universally agreed strategy for assembling a successful scientific article, it is undeniable that some basic notions, gathered after decades of experience, may help increasing the chance of acceptance of a scientific manuscript. Therefore, the purpose of this article is to present a personal and arbitrary perspective on how to write a scientific article, entailing a tentative flowchart and a checklist describing the most important aspects characterizing each section of the manuscript. The final suggestion, which can be summarized in one simple and straightforward concept, is that you should always remember that a scientific article is meant to be read by others (i.e., referees and readers) and not by yourself.

Multilevel Modeling in Psychosomatic Medicine Research

PubMed Central

Myers, Nicholas D.; Brincks, Ahnalee M.; Ames, Allison J.; Prado, Guillermo J.; Penedo, Frank J.; Benedict, Catherine

2012-01-01

The primary purpose of this manuscript is to provide an overview of multilevel modeling for Psychosomatic Medicine readers and contributors. The manuscript begins with a general introduction to multilevel modeling. Multilevel regression modeling at two-levels is emphasized because of its prevalence in psychosomatic medicine research. Simulated datasets based on some core ideas from the Familias Unidas effectiveness study are used to illustrate key concepts including: communication of model specification, parameter interpretation, sample size and power, and missing data. Input and key output files from Mplus and SAS are provided. A cluster randomized trial with repeated measures (i.e., three-level regression model) is then briefly presented with simulated data based on some core ideas from a cognitive behavioral stress management intervention in prostate cancer. PMID:23107843

Towards the estimation of effect measures in studies using respondent-driven sampling.

PubMed

Rotondi, Michael A

2014-06-01

Respondent-driven sampling (RDS) is an increasingly common sampling technique to recruit hidden populations. Statistical methods for RDS are not straightforward due to the correlation between individual outcomes and subject weighting; thus, analyses are typically limited to estimation of population proportions. This manuscript applies the method of variance estimates recovery (MOVER) to construct confidence intervals for effect measures such as risk difference (difference of proportions) or relative risk in studies using RDS. To illustrate the approach, MOVER is used to construct confidence intervals for differences in the prevalence of demographic characteristics between an RDS study and convenience study of injection drug users. MOVER is then applied to obtain a confidence interval for the relative risk between education levels and HIV seropositivity and current infection with syphilis, respectively. This approach provides a simple method to construct confidence intervals for effect measures in RDS studies. Since it only relies on a proportion and appropriate confidence limits, it can also be applied to previously published manuscripts.

Updates in medical malpractice: an otology perspective.

PubMed

Ruhl, Douglas S; Littlefield, Philip D

2015-10-01

Most surgeons at some point are involved in a medical malpractice case. There has been an increase in the number of manuscripts that analyse malpractice databases and insurance claims, as well as commentaries on the current medicolegal climate recently. This manuscript broadly reviews articles of interest to all providers and then focuses on malpractice in otology. Medical malpractice articles (particularly topics related to otologic surgery published within the last 1-2 years) were searched. The growing body of literature can be divided into the themes of general negligence, mitigating injuries and the use of clinical practice guidelines in the courtroom as guidance for expert witnesses. Recent findings suggest that the frequency of malpractice claims may be decreasing. Hearing loss and facial nerve injury are the most common injuries associated with otologic surgery. These injuries can be costly when negligence is found. Clinic practice guidelines are slowly being used as evidence in the courtroom and there are established guidelines that an expert witness must follow should a surgeon be called to give testimony.

Bridging the Otolaryngology Peer Review Knowledge Gap: A Call for a Residency Development Program.

PubMed

Schmalbach, Cecelia E

2016-07-01

Current otolaryngology literature and future scientific direction rely heavily on a rigorous peer review process. Just as manuscripts warrant thoughtful review with constructive feedback to the authors, the same can be said for critiques written by novice peer reviewers. Formal scientific peer review training programs are lacking. Recognizing this knowledge gap, Otolaryngology-Head and Neck Surgery is excited to offer its new Resident Reviewer Development Program. All otolaryngology residents who are postgraduate year 2 and above and in excellent academic standing are eligible to participate in this mentored program, during which they will conduct 6 manuscript reviews under the direction of a seasoned reviewer in his or her subspecialty area of interest. By completing reviews alongside a mentor, participants gain the required skills to master the peer review process-a first step that often leads to journal editorial board and associate editor invitations. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.

SpectraPlot.com: Integrated spectroscopic modeling of atomic and molecular gases

NASA Astrophysics Data System (ADS)

Goldenstein, Christopher S.; Miller, Victor A.; Mitchell Spearrin, R.; Strand, Christopher L.

2017-10-01

SpectraPlot is a web-based application for simulating spectra of atomic and molecular gases. At the time this manuscript was written, SpectraPlot consisted of four primary tools for calculating: (1) atomic and molecular absorption spectra, (2) atomic and molecular emission spectra, (3) transition linestrengths, and (4) blackbody emission spectra. These tools currently employ the NIST ASD, HITRAN2012, and HITEMP2010 databases to perform line-by-line simulations of spectra. SpectraPlot employs a modular, integrated architecture, enabling multiple simulations across multiple databases and/or thermodynamic conditions to be visualized in an interactive plot window. The primary objective of this paper is to describe the architecture and spectroscopic models employed by SpectraPlot in order to provide its users with the knowledge required to understand the capabilities and limitations of simulations performed using SpectraPlot. Further, this manuscript discusses the accuracy of several underlying approximations used to decrease computational time, in particular, the use of far-wing cutoff criteria.

Summary of SPT based field case history data of CETIN (2016) database

USGS Publications Warehouse

Onder Cetin, K.; Seed, Raymond B.; Kayen, Robert E.; Moss, Robb E. S.; Bilge, H. Tolga; Ilgac, Makbule; Chowdhury, Khaled

2016-01-01

This report provides documentation of the Cetin et al. (2016) field performance case histories, probabilistic maximum likelihood assessment and the sources of differences between the liquefaction triggering resistance estimations (CRR values) of the widely used liquefaction triggering relationships of Seed et al. (1985), Cetin et al. (2004, 2016) and Boulanger and Idriss (2012). Cetin et al. (2016-a) presented a concise summary of the improved database and the updated triggering relationships. For the sake of completeness, as part of Chapter 2 of this report, Cetin et al. (2016-a) manuscript is re-presented, as edited to include the electronic supplements, and a broader and more detailed documentation of all of case histories. This broader and more detailed documentation along with the interpretations of other researchers is presented in Appendix A. Similarly, site response analyses details and results from Cetin (2000) is re-presented in Appendix B. To enable the readers to quickly refer to Cetin and Seed (2004), it is also included in Appendix C. The sources of differences between the liquefaction triggering resistance estimations (CRR values) of the widely used liquefaction triggering relationships of Seed et al. (1985), Cetin et al. (2004) and Boulanger and Idriss (2012) were discussed in Cetin et al. (2016-b). Again, for the sake of completeness, as part of Chapter 3 of this report, Cetin et al. (2016-b) manuscript is re-presented, as edited to the include of electronic supplements, and a detailed response to issues addressed by Idriss and Boulanger (2012). Also, the technical response letter (Cetin, 2014) prepared at the request of the members of the NRC Committee on the State of the Art and Practice in Earthquake Induced Soil Liquefaction Assessment, is given in Appendix D, which is helpful to follow the technical discussions. This report is intended only as a concise summary of a vast amount of data. The interpretations presented are those of the research team. A more detailed description of some of the details of the methods and procedures used to evaluate and analyze these field performance case histories is also presented in Cetin (2000) and Cetin et al. (2000) though the final evaluations presented in this report are the most recent interpretations undertaken under these current studies.

EAD in the Department of Special Collections and Western Manuscripts at the Bodleian Library, United Kingdom

ERIC Educational Resources Information Center

Webb, Mike

2005-01-01

The strategy for conversion to electronic cataloguing of western manuscripts in the Bodleian Library has been to a large extent determined by circumstances--the size and variety of the manuscript collections, the existence of detailed published catalogues for the earlier collections, the availability of funds for specific purposes, and, above all,…

Analysis of the Revision Process by American Journal of Roentgenology Reviewers and Section Editors: Metrics of Rejected Manuscripts and Their Final Disposition.

PubMed

Cejas, Claudia

2017-06-01

The objective of this study was to evaluate metrics related to manuscripts rejected by AJR with and without review during 2014 and to determine their final disposition: no record of eventual publication, eventually published, published with modified authors and title, published with the same title but modified authors, and published with modified title but the same authors. A total of 1245 unsolicited manuscripts submitted from January to December 2014 were included in this retrospective analysis. Data were extracted from the AJR's manuscript submission system. Standard statistical analysis was used to assess the fate of a sample of 200 rejected manuscripts. Of the 200 manuscripts studied, 117 (59%) were published in other scientific journals (61 with revision, 56 without revision; Χ 2 = 0.329, p = 0.566). Thirty-two of the 61 manuscripts (52%) rejected after peer review were later published in other journals without changes in their titles or authors, 16 (26%) with changes only in authors, 10 (16%) with changes only in their titles, and three (5%) with changes in authors and titles. Twenty-six of the 56 manuscripts (46%) rejected without peer review were published without changes in their titles or authors, 17 (30%) with changes in authors, 11 (20%) with changes only in their titles, and two (4%) with changes in both authors and titles (p = 0.686). Ten articles were published in open access journals. Of the remaining articles, those that had been reviewed were published in journals with a mean impact factor ± SD of 2.37 ± 1.30, and those that had not been reviewed were published in journals with a mean impact factor of 2.04 ± 1.06. Analysis of the 25th and 75th percentiles revealed that values were also higher for the group rejected with review (Wilcoxon rank sum test: W = 1679, p = 0.1127). Out of 61 articles rejected for publication with review, 52.5% were published with changes to their abstracts, whereas the remaining 47.5% were unchanged. This analysis found that manuscripts submitted to AJR that were rejected after review were published in journals with higher impact factors than those rejected without review. The commentaries provided by AJR reviewers and section editors appear to improve the quality of rejected manuscripts and thus contribute to the scientific community.

SciRide Finder: a citation-based paradigm in biomedical literature search.

PubMed

Volanakis, Adam; Krawczyk, Konrad

2018-04-18

There are more than 26 million peer-reviewed biomedical research items according to Medline/PubMed. This breadth of information is indicative of the progress in biomedical sciences on one hand, but an overload for scientists performing literature searches on the other. A major portion of scientific literature search is to find statements, numbers and protocols that can be cited to build an evidence-based narrative for a new manuscript. Because science builds on prior knowledge, such information has likely been written out and cited in an older manuscript. Thus, Cited Statements, pieces of text from scientific literature supported by citing other peer-reviewed publications, carry significant amount of condensed information on prior art. Based on this principle, we propose a literature search service, SciRide Finder (finder.sciride.org), which constrains the search corpus to such Cited Statements only. We demonstrate that Cited Statements can carry different information to this found in titles/abstracts and full text, giving access to alternative literature search results than traditional search engines. We further show how presenting search results as a list of Cited Statements allows researchers to easily find information to build an evidence-based narrative for their own manuscripts.

Scholarship, publication, and career advancement in health professions education: AMEE Guide No. 43.

PubMed

McGaghie, William C

2009-07-01

Scholarship and publication are key contributors to career advancement in health professions education worldwide. Scholarship is expressed in many ways including original research; integration and synthesis of ideas and data, often across disciplines; application of skill and knowledge to problems that have consequences for health professionals, students, and patients; and teaching in many forms. Professional publication also has diverse outlets ranging from empirical articles in peer reviewed journals, textbook chapters, videos, simulation technologies, and many other means of expression. Scholarship and publication are evaluated and judged using criteria that are consensual, public, and transparent. This three-part AMEE Guide presents advice about how to prepare and publish health professions education research reports and other forms of scholarship in professional journals and other outlets. Part One addresses scholarship-its varieties, assessment, and attributes of productive scholars and scholarly teams. Part Two maps the road to publication, beginning with what's important and reportable and moving to manuscript planning and writing, gauging manuscript quality, manuscript submission and review, and writing in English. Part Three offers 21 practical suggestions about how to advance a successful and satisfying career in the academic health professions. Concluding remarks encourage health professions educators to pursue scholarship with vision and reflection.

Methodology: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

PubMed

Ornelas, Joe; Dichter, Jeffrey R; Devereaux, Asha V; Kissoon, Niranjan; Livinski, Alicia; Christian, Michael D

2014-10-01

Natural disasters, industrial accidents, terrorism attacks, and pandemics all have the capacity to result in large numbers of critically ill or injured patients. This supplement provides suggestions for all those involved in a disaster or pandemic with multiple critically ill patients, including front-line clinicians, hospital administrators, professional societies, and public health or government officials. The field of disaster medicine does not have the required body of evidence needed to undergo a traditional guideline development process. In result, consensus statement-development methodology was used to capture the highest-caliber expert opinion in a structured, scientific approach. Task Force Executive Committee members identified core topic areas regarding the provision of care to critically ill or injured patients from pandemics or disasters and subsequently assembled an international panel for each identified area. International disaster medicine experts were brought together to identify key questions (in a population, intervention, comparator, outcome [PICO]-based format) within each of the core topic areas. Comprehensive literature searches were then conducted to identify studies upon which evidence-based recommendations could be made. No studies of sufficient quality were identified. Therefore, the panel developed expert opinion-based suggestions that are presented in this supplement using a modified Delphi process. A total of 315 suggestions were drafted across all topic groups. After two rounds of a Delphi consensus-development process, 267 suggestions were chosen by the panel to include in the document and published in a total of 12 manuscripts composing the core chapters of this supplement. Draft manuscripts were prepared by the topic editor and members of the working groups for each of the topics, producing a total of 11 papers. Once the preliminary drafts were received, the Executive Committee (Writing Committee) then met to review, edit, and promote alignment of all of the primary drafts of the manuscripts prepared by the topic editors and their groups. The topic editors then revised their manuscripts based on the Executive Committee's edits and comments. The Writing Committee subsequently reviewed the updated drafts and prepared the final manuscripts for submission to the Guidelines Oversight Committee (GOC). The manuscripts subsequently underwent review by the GOC, including external review as well as peer review for the journal publication. The Writing Committee received the feedback from the reviewers and modified the manuscripts as required. Based on a robust and transparent process, this project used rigorous methodology to produce clinically relevant, trustworthy consensus statements, with the aim to provide needed guidance on treatment and procedures for practitioners, hospital administrators, and public health and government officials when addressing the care of critically ill or injured patients in disasters or pandemics.

[Medical manuscript of Mihail Plamenac, a priest].

PubMed

Milović, I

1998-01-01

It is known that collections of popular medical prescriptions and instructions appeared in areas without educated physicians, and all previously published manuscripts of this kind are inevitably anonymous. The reported manuscript comprises 23 pages written in sepia ink, appendixed to a prayer book published in 1747, containing popular medical instructions and prescriptions collected and practiced by orthodox priest Mihailo Plamenac in Montenegro at the turn of the 18th century. Mihailo Plamenac took an important part in historical events, as documented by numerous domestic historical data and several letters discovered in The Archives of Vienna. Being the only literate persons at the time, priests were both politicians and military officers, but they also offered medical services to the population. The manuscript comprises advices for various common emergencies (snake bites, urinary retention, contusions, fever, burns, eye injuries, rabies, otitis, traumatic wryneck) and diseases(impetigo, scabies, infertility, gastric ulcer, low back pain) as well as for certain poorly defined conditions (chest pain, abdominal discomfort). Besides medically fully adequate treatment, for example, the remedy against scabies containing sulfur, there are numerous examples of magic and ritual pagan elements, including famous medieval SATOR formula against rabies. Most of the herbs used in prescriptions have been identified: fig, dog rose, hyssop, leek, laurel, absinthe, rosemary, mallow, cypress, elder, endive, mangel, orache, ivy. The manuscript is the first manuscript undoubtedly attributed to a well known historical personality, as indicated in the first page of the manuscript: "This is a medical prayer book by Mihailo Plamenac, left to him by his ancestors."

Estimating Tissue Iron Burden: Current Status and Future Prospects

PubMed Central

Wood, John C.

2015-01-01

SUMMARY Iron overload is becoming an increasing problem as haemoglobinopathy patients gain greater access to good medical care and as therapies for myelodysplastic syndromes improve. Therapeutic options for iron chelation therapy have increased and many patients now receive combination therapies. However, optimal utilization of iron chelation therapy requires knowledge not only of the total body iron burden but the relative iron distribution among the different organs. The physiological basis for extrahepatic iron deposition is presented in order to help identify patients at highest risk for cardiac and endocrine complications. This manuscript reviews the current state of the art for monitoring global iron overload status as well as its compartmentalization. Plasma markers, computerized tomography, liver biopsy, magnetic susceptibility devices and magnetic resonance imaging (MRI) techniques are all discussed but MRI has come to dominate clinical practice. The potential impact of recent pancreatic and pituitary MRI studies on clinical practice are discussed as well as other works-in-progress. Clinical protocols are derived from experience in haemoglobinopathies but may provide useful guiding principles for other iron overload disorders, such as myelodysplastic syndromes. PMID:25765344

Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity

PubMed Central

Andrade, Joana M; Faustino, Célia; Garcia, Catarina; Ladeiras, Diogo; Reis, Catarina P; Rijo, Patrícia

2018-01-01

The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research in drug discovery, natural products can provide new and important leads against various pharmacological targets. This work pioneers an extensive and an updated literature review on the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. Therefore, a search was made in the databases PubMed, ScienceDirect and Web of Science with the terms ‘rosemary’, ‘Rosmarinus officinalis’, ‘rosmarinic acid’ ‘carnosol’ and ‘carnosic acid’, which included 286 articles published since 1990 about rosemary's pharmacological activities and their isolated compounds. According to these references, there has been an increasing interest in the therapeutic properties of this plant, regarding carnosic acid, carnosol, rosmarinic acid and the essential oil. The present manuscript provides an updated review upon the most reported activities on R. officinalis and its active constituents. PMID:29682318

ICY 2012 Highlights

USDA-ARS?s Scientific Manuscript database

This publication is the foreword to a special edition of the journal Yeast that includes selected review manuscripts resulting from presentations at the 13th International Congress on Yeasts that was held in Madison, Wisconsin, USA, Aug. 26-30, 2012. The papers, by various international authors, foc...

Retraction: Association between the use of biomass fuels on respiratory health of workers in food catering enterprises in Nairobi Kenya. Pan Afr Med J. 2013 May 6;15:12. doi: 10.11604/pamj.2013.15.12.1831.

PubMed

2014-01-01

The editors of the Pan African Medical Journal retract the manuscript above. The manuscript has been the subject of a protracted and unresolved authors dispute. Not all the authors listed in this manuscript consented to the retraction.

Metaphor and Pedagogy in Early Buddhist Literature: An Edition and Study of Two Sutras from the Senior Collection of Gandhari Manuscripts

ERIC Educational Resources Information Center

Marino, Joseph

2017-01-01

This dissertation examines the role of metaphorical language in early Buddhist literature through the lens of two previously unpublished Gandhari sutras on a manuscript from the Robert Senior Collection. At the microscopic level, I offer an edition, translation, and textual analysis of a Buddhist manuscript containing two Sa?yuktagama-type sutras…

[Kabikaj-(see symbol test) and the buttercup: Ranunculus asiaticus L].

PubMed

Yavuz, Mustafa

In Islamic tradition, the talismanic inscription "Yâ Kebîkeç- O Kabikaj" was believed to protect manuscripts against insects. Also in medicinal manuscripts there are several passages referring to Kabikaj used as a drug. In this study, the use of Kabikaj in medicinal manuscripts is investigated. As a result, Kabikaj is stated to be a species of Ranunculaceae family: Ranunculus asiaticus L.

[Report of the editors, 2013].

PubMed

García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

2014-01-01

The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day, better. Copyright © 2013 Elsevier España, S.L. All rights reserved.

Invited review: Incidence, risk factors, and effects of clinical mastitis recurrence in dairy cows.

PubMed

Jamali, Hossein; Barkema, Herman W; Jacques, Mario; Lavallée-Bourget, Eve-Marie; Malouin, François; Saini, Vineet; Stryhn, Henrik; Dufour, Simon

2018-06-01

Clinical mastitis (CM) is one of the most frequent and costly diseases in dairy cows. A frustrating aspect of CM is its recurrent nature. This review was conducted to synthesize knowledge on risk of repeated cases of CM, effects of recurrent CM cases, and risk factors for CM recurrence. A systematic review methodology was used to identify articles for this narrative review. Searches were performed to identify relevant scientific literature published after 1989 in English or French from 2 databases (PubMed and CAB Abstracts) and 1 search platform (Web of Science). Fifty-seven manuscripts were selected for qualitative synthesis according to the inclusion criteria. Among the 57 manuscripts selected in this review, a description of CM recurrence, its risk factors, and effects were investigated and reported in 33, 37, and 19 selected manuscripts, respectively. Meta-analysis and meta-regression analyses were used to compute risk ratio comparing risk of CM in cows that already had 1 CM event in the current lactation with risk of CM in healthy cows. For these analyses, 9 manuscripts that reported the total number of lactations followed and the number of lactations with ≤1 and ≤2 CM cases were used. When summarizing results from studies requiring ≥5 d between CM events to consider a CM event as a new case, we observed no significant change in CM susceptibility following a first CM case (risk ratio: 0.99; 95% confidence interval: 0.86-1.14). However, for studies using a more liberal CM recurrence definition (i.e., only 24 h between CM events to consider new CM cases), we observed a 1.54 times greater CM risk (95% confidence interval: 1.20-1.97) for cows that already had 1 CM event in the current lactation compared with healthy cows. The most important risk factors for CM recurrence were parity (i.e., higher risk in older cows), a higher milk production, pathogen species involved in the preceding case, and whether a bacteriological cure was observed following the preceding case. The most important effects of recurrent CM were the milk yield reduction following a recurrent CM case, which was reported to be similar to that of the first CM case, and the increased risk of culling and mortality, which were reported to surpass those of first CM cases. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Signal- and Listener-Based Factors in Complex Auditory Pattern Perception

DTIC Science & Technology

1993-11-09

manuscripts to leading journals . Two of these were based on research that was summarized in last year’s Annual Technical Report . The current report ...PERFORMING ORGANI1ZATION REPORT NUMIERIIS) S. MONITORING ORGANIZATION REPORT NuMBERISk ______________________AM USR- Th-, Ga NAME Of PERFORMING ORGANIZATION...Ob. OFFICE SYMBOL 7&. NAME OF MONITORING ORGANIZAFON Department of Psychol1ogy 4f apgdscabde,t Air Force O)ff ice of S cientific Researcl SUNY Stony

Investigation of source location determination from Magsat magnetic anomalies: The Euler method approach

NASA Technical Reports Server (NTRS)

Ravat, Dhananjay

1996-01-01

The applicability of the Euler method of source location determination was investigated on several model situations pertinent to satellite-data scale situations as well as Magsat data of Europe. Our investigations enabled us to understand the end-member cases for which the Euler method will work with the present satellite magnetic data and also the cases for which the assumptions implicit in the Euler method will not be met by the present satellite magnetic data. These results have been presented in one invited lecture at the Indo-US workshop on Geomagnetism in Studies of the Earth's Interior in August 1994 in Pune, India, and at one presentation at the 21st General Assembly of the IUGG in July 1995 in Boulder, CO. A new method, called Anomaly Attenuation Rate (AAR) Method (based on the Euler method), was developed during this study. This method is scale-independent and is appropriate to locate centroids of semi-compact three dimensional sources of gravity and magnetic anomalies. The method was presented during 1996 Spring AGU meeting and a manuscript describing this method is being prepared for its submission to a high-ranking journal. The grant has resulted in 3 papers and presentations at national and international meetings and one manuscript of a paper (to be submitted shortly to a reputable journal).

An Introduction to Boiler Water Chemistry for the Marine Engineer: A Text of Audio-Tutorial Instruction.

ERIC Educational Resources Information Center

Schlenker, Richard M.; And Others

Presented is a manuscript for an introductory boiler water chemistry course for marine engineer education. The course is modular, self-paced, audio-tutorial, contract graded and combined lecture-laboratory instructed. Lectures are presented to students individually via audio-tapes and 35 mm slides. The course consists of a total of 17 modules -…

First Symposium on Aviation Psychology. Proceedings of the Symposium on Aviation Psychology (Columbus, Ohio, April 21 and 22, 1981).

ERIC Educational Resources Information Center

Jensen, R. S.

This volume contains five complete manuscripts and two abstracts presented, and three papers submitted but not presented, at this symposium on aviation psychology. The objective of the symposium was to critically examine the impact of high technology on the role, responsibility, authority, and performance of human operators in modern aircraft and…

ADCIS Conference Proceedings. Computer-Based Instruction (28th, Washington, D.C., November 10-13, 1986).

ERIC Educational Resources Information Center

Association for the Development of Computer-based Instructional Systems.

This volume is divided into full formal paper manuscripts and 200-word abstracts of presentations that were made without submitting formal papers. The 73 papers presented in full represent recent research and applications in the field of computer-based instruction. They are organized into 13 sections by special interest group: (1) Computer-Based…

Promoting quality and safety in women's health through the use of transdisciplinary clinical simulation educational modules: methodology and a pilot trial.

PubMed

Montgomery, Kymberlee; Morse, Catherine; Smith-Glasgow, Mary Ellen; Posmontier, Bobbie; Follen, Michele

2012-02-01

This manuscript presents the methodology used to assess the impact of a clinical simulation module used for training providers specializing in women's health. The methodology presented here will be used for a quantitative study in the future. Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved.

Hepatic sarcoidosis: pathogenesis, clinical context, and treatment options.

PubMed

Syed, Umer; Alkhawam, Hassan; Bakhit, Mena; Companioni, Rafael A Ching; Walfish, Aron

2016-09-01

Sarcoidosis is typically characterized as a non-caseating granulomatous disease that has the ability to affect multiple different organ systems. Although extra-thoracic sarcoidosis can occur in the presence and also without lung involvement, isolated extra-pulmonary disease is rare. The liver is the third most commonly affected organ system after the lungs and lymph nodes. When discussing hepatic sarcoidosis it is important to keep in mind that many patients in this population may not present as one would typically expect since most of the patients are asymptomatic or have mild presentations. Therefore, the diagnosis can be difficult at times since no single laboratory or imaging study can definitively diagnose this systemic disease. In the rare case of some patients where there is difficulty in discerning between different pathologies, the use of image-guided tissue biopsy may be necessary to establish a diagnosis. At the current time, there are no clear guidelines for the management of hepatic sarcoidosis and are mostly dependent on a patient's clinical status at time of presentation. The current body of research in regard to treatment suggests steroids to be the mainstay of therapy. However, there is a role for additional immunosuppressive therapy in cases where the initial treatment is refractory to steroids. In this manuscript, we discussed the pathogenesis of liver sarcoidosis and context of its presentation. In addition, the differential diagnosis and imaging evaluation in this population is discussed. Finally, treatment options are reviewed in setting of previous studies for liver sarcoidosis.

DEVELOPMENTAL DISRUPTION OF THYROID HORMONE: CORRELATIONS WITH HEARING DYSFUNCTION IN RATS.

EPA Science Inventory

A manuscript presents evidence that thyroxine (T4) is a good biomarker-of-effect for developmental neurotoxicity associated with exposure to environmental thyrotoxicants. A major uncertainty in assessing the risks of developmental exposure to thyrotoxicants is the lack of a clear...

Researching the Vietnam Conflict through U.S. Archival Sources.

ERIC Educational Resources Information Center

Marlatt, Greta E.

1995-01-01

Presents a pathfinder for the researcher interested in locating materials pertaining to the U.S. involvement in the Vietnam conflict. Highlight include historical background; information sources, including the National Archives, oral histories, manuscripts, federal reports, National Technical Information Service, and special collections. Seven…

Team-Based Classroom Pedagogy Reframed: The Student Perspective

ERIC Educational Resources Information Center

Schultz, Jennifer L.; Wilson, Joel R.; Hess, Kenneth C.

2010-01-01

Postsecondary learning environments often utilize team-based pedagogical practices to challenge and support student learning outcomes. This manuscript presents the findings of a qualitative research study that analyzed the viewpoints and perceptions of group or team-based projects among undergraduate business students. Results identified five…

Greenhouse gas emissions from soil under changing environmental conditions

USDA-ARS?s Scientific Manuscript database

This manuscript is the Guest Editors’ Introduction to a special issue on greenhouse gas emissions from agriculture. The papers were assembled following presentation at EuroSoil 2012. Exchange of greenhouse gases between soils and the atmosphere is a natural consequence of several ecosystem process...

Imaging of Adult Ocular and Orbital Pathology - a Pictorial Review

PubMed Central

Grech, Reuben; Cornish, Kurt Spiteri; Galvin, Patrick Leo; Grech, Stephan; Looby, Seamus; O’Hare, Alan; Mizzi, Adrian; Thornton, John; Brennan, Paul

2014-01-01

Orbital pathology often presents a diagnostic challenge to the reporting radiologist. The aetiology is protean, and clinical input is therefore often necessary to narrow the differential diagnosis. With this manuscript, we provide a pictorial review of adult ocular and orbital pathology. PMID:24967016

Plagiarism: A silent epidemic in scientific writing - Reasons, recognition and remedies.

PubMed

Debnath, Jyotindu

2016-04-01

Plagiarism is one of the most serious forms of scientific misconduct prevalent today and is an important reason for significant proportion of rejection of manuscripts and retraction of published articles. It is time for the medical fraternity to unanimously adopt a 'zero tolerance' policy towards this menace. While responsibility for ensuring a plagiarism-free manuscript primarily lies with the authors, editors cannot absolve themselves of their accountability. The only way to write a plagiarism-free manuscript for an author is to write an article in his/her own words, literally and figuratively. This article discusses various types of plagiarism, reasons for increasingly reported instances of plagiarism, pros and cons of use of plagiarism detection tools for detecting plagiarism and role of authors and editors in preventing/avoiding plagiarism in a submitted manuscript. Regular usage of professional plagiarism detection tools for similarity checks with critical interpretation by the editorial team at the pre-review stage will certainly help in reducing the menace of plagiarism in submitted manuscripts.

The dome-shaped Fresnel-Köhler concentrator

NASA Astrophysics Data System (ADS)

Zamora, P.; Benitez, P.; Li, Y.; Miñano, J. C.; Mendes-Lopes, J.; Araki, K.

2012-10-01

Manufacturing tolerances, along with a high concentration ratio, are key issues in order to obtain cheap CPV systems for mass production. Consequently, this manuscript presents a novel tolerant and cost effective concentrator optic: the domed-shaped Fresnel-Köhler, presenting a curved Fresnel lens as Primary Optical Element (POE). This concentrator is based on two previous successful CPV designs: the FK concentrator, based on a flat Fresnel lens, and the dome-shaped Fresnel lens system developed by Daido Steel, resulting on a superior concentrator. The manuscript shows outstanding simulation results for geometrical concentration factor of Cg = 1,230x: high tolerance and high optical efficiency, achieving acceptance angles of 1.18° (dealing to a CAP*=0.72) and efficiencies over 85% (without any anti-reflective coating). Moreover, Köhler integration provides good irradiance uniformity on the cell surface without increasing system complexity by means of any extra element. Daido Steel advanced technique for demolding injected plastic pieces will allow for easy manufacture of the dome-shaped POE of DFK concentrator.

Statistical and data reporting guidelines for the European Journal of Cardio-Thoracic Surgery and the Interactive CardioVascular and Thoracic Surgery.

PubMed

Hickey, Graeme L; Dunning, Joel; Seifert, Burkhardt; Sodeck, Gottfried; Carr, Matthew J; Burger, Hans Ulrich; Beyersdorf, Friedhelm

2015-08-01

As part of the peer review process for the European Journal of Cardio-Thoracic Surgery (EJCTS) and the Interactive CardioVascular and Thoracic Surgery (ICVTS), a statistician reviews any manuscript that includes a statistical analysis. To facilitate authors considering submitting a manuscript and to make it clearer about the expectations of the statistical reviewers, we present up-to-date guidelines for authors on statistical and data reporting specifically in these journals. The number of statistical methods used in the cardiothoracic literature is vast, as are the ways in which data are presented. Therefore, we narrow the scope of these guidelines to cover the most common applications submitted to the EJCTS and ICVTS, focusing in particular on those that the statistical reviewers most frequently comment on. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Quantified Energy Dissipation Rates in the Terrestrial Bow Shock. 1.; Analysis Techniques and Methodology

NASA Technical Reports Server (NTRS)

Wilson, L. B., III; Sibeck, D. G.; Breneman, A.W.; Le Contel, O.; Cully, C.; Turner, D. L.; Angelopoulos, V.; Malaspina, D. M.

2014-01-01

We present a detailed outline and discussion of the analysis techniques used to compare the relevance of different energy dissipation mechanisms at collisionless shock waves. We show that the low-frequency, quasi-static fields contribute less to ohmic energy dissipation, (-j · E ) (minus current density times measured electric field), than their high-frequency counterparts. In fact, we found that high-frequency, large-amplitude (greater than 100 millivolts per meter and/or greater than 1 nanotesla) waves are ubiquitous in the transition region of collisionless shocks. We quantitatively show that their fields, through wave-particle interactions, cause enough energy dissipation to regulate the global structure of collisionless shocks. The purpose of this paper, part one of two, is to outline and describe in detail the background, analysis techniques, and theoretical motivation for our new results presented in the companion paper. The companion paper presents the results of our quantitative energy dissipation rate estimates and discusses the implications. Together, the two manuscripts present the first study quantifying the contribution that high-frequency waves provide, through wave-particle interactions, to the total energy dissipation budget of collisionless shock waves.

[Methamphetamine - just another stimulant or a more complex problem?].

PubMed

Lecomte, Tania; Massé, Marjolaine

2014-01-01

Methamphetamine (MA) has recently become very popular in the media, due in part to its increasing popularity as well as its psychotropic effects and the negative consequences of its use. Is it a stimulant like any other, or does methamphetamine use lead to specific difficulties in its users? The aim of this article is to provide a brief review of the literature by explaining some of the reasons for its popularity in Canada as well as the physical, dental, psychiatric, cognitive and legal problems associated with its use. MA's popularity: Regarding its popularity, MA has benefitted from multiple factors, namely its low cost for users and manufacturers, its quick and intense psychotropic effects (increased energy, sexual arousal, rapid thinking, sleeplessness, lack of appetite), its easy access, as well as its various methods of ingestion (nasal, oral, injection). MA abuse also results in a multitude of negative effects, both physical and mental. MA's physical effects: In terms of negative physical effects, cardiac problems, skin infections, sexually transmitted (and injection-related) diseases as well as meth mouth are described. MA's mental effects: In terms of mental consequences, two recently published Canadian studies revealing high rates of depression symptoms and of sustained psychotic symptoms in a subgroup of MA users are presented. Studies reporting various cognitive deficits in MA user are also reviewed, including reports of high prevalence of childhood attention deficit and hyperactivity disorder diagnoses among adult MA users. Furthermore, MA abusers are documented as having been highly exposed to trauma in their lives, with many presenting with post-traumatic stress disorder criteria. This manuscript also explores the reasons behind the forensic profiles of individuals using MA, particularly the increased tendency toward violent acts, the high incarceration rates of the homeless users and the high percentage of individuals diagnosed with antisocial personality disorder reported in studies. In terms of user profiles, various methods of ingestion, frequency of use as well as combination with other drugs are described, with a special focus on the frequent polysubstance abuse found in MA users and the reality of bingers. This manuscript describes specific treatments designed for stimulant users such as MA abusers, namely the MATRIX program, as well as modifications piloted for those with comorbid depression. Pharmacological treatments, as well as antioxidant supplements, are also discussed although they have not yielded positive results with humans to date. Overall, our goal in this manuscript is to highlight the complexity of the difficulties faced by MA users as well as the limited ability of currently available treatments to address the multiple needs associated with this complexity.

Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells

DTIC Science & Technology

2014-10-01

15 Preprint of Bansal et al., Nature Comm., in revision. (Manuscript, supplemental material and...established, treatment with C-209 resulted in a significant antitumor activity (See Figs. 7 of Bansal et al., Nature Comm. manuscript in revision that is...combination therapy. (See Fig. 7e-g of Bansal et al., Nature Comm. manuscript in revision that is attached in the Appendix). Task #5. We selected

Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

PubMed Central

1994-01-01

In the 13 years since it was first published the "Uniform requirements for manuscripts submitted to biomedical journals" (the Vancouver style), developed by the International Committee of Medical Journal Editors, has been widely accepted by both authors and editors; over 400 journals have stated that they will consider manuscripts that conform to its requirements. This is the fourth edition of the "Uniform requirements." PMID:8287338

Towards structured sharing of raw and derived neuroimaging data across existing resources

PubMed Central

Keator, D.B.; Helmer, K.; Steffener, J.; Turner, J.A.; Van Erp, T.G.M.; Gadde, S.; Ashish, N.; Burns, G.A.; Nichols, B.N.

2013-01-01

Data sharing efforts increasingly contribute to the acceleration of scientific discovery. Neuroimaging data is accumulating in distributed domain-specific databases and there is currently no integrated access mechanism nor an accepted format for the critically important meta-data that is necessary for making use of the combined, available neuroimaging data. In this manuscript, we present work from the Derived Data Working Group, an open-access group sponsored by the Biomedical Informatics Research Network (BIRN) and the International Neuroimaging Coordinating Facility (INCF) focused on practical tools for distributed access to neuroimaging data. The working group develops models and tools facilitating the structured interchange of neuroimaging meta-data and is making progress towards a unified set of tools for such data and meta-data exchange. We report on the key components required for integrated access to raw and derived neuroimaging data as well as associated meta-data and provenance across neuroimaging resources. The components include (1) a structured terminology that provides semantic context to data, (2) a formal data model for neuroimaging with robust tracking of data provenance, (3) a web service-based application programming interface (API) that provides a consistent mechanism to access and query the data model, and (4) a provenance library that can be used for the extraction of provenance data by image analysts and imaging software developers. We believe that the framework and set of tools outlined in this manuscript have great potential for solving many of the issues the neuroimaging community faces when sharing raw and derived neuroimaging data across the various existing database systems for the purpose of accelerating scientific discovery. PMID:23727024

Current State of Commercial Wearable Technology in Physical Activity Monitoring 2015–2017

PubMed Central

BUNN, JENNIFER A.; NAVALTA, JAMES W.; FOUNTAINE, CHARLES J.; REECE, JOEL D.

2018-01-01

Wearable physical activity trackers are a popular and useful method to collect biometric information at rest and during exercise. The purpose of this systematic review was to summarize recent findings of wearable devices for biometric information related to steps, heart rate, and caloric expenditure for several devices that hold a large portion of the market share. Searches were conducted in both PubMed and SPORTdiscus. Filters included: humans, within the last 5 years, English, full-text, and adult 19+ years. Manuscripts were retained if they included an exercise component of 5-min or greater and had 20 or more participants. A total of 10 articles were retained for this review. Overall, wearable devices tend to underestimate energy expenditure compared to criterion laboratory measures, however at higher intensities of activity energy expenditure is underestimated. All wrist and forearm devices had a tendency to underestimate heart rate, and this error was generally greater at higher exercise intensities and those that included greater arm movement. Heart rate measurement was also typically better at rest and while exercising on a cycle ergometer compared to exercise on a treadmill or elliptical machine. Step count was underestimated at slower walking speeds and in free-living conditions, but improved accuracy at faster speeds. The majority of the studies reviewed in the present manuscript employed different methods to assess validity and reliability of wearable technology, making it difficult to compare devices. Standardized protocols would provide guidance for researchers to evaluate research-grade devices as well as commercial devices used by the lay public. PMID:29541338

“Do You Expect Me to Receive PTSD Care in a Setting Where Most of the Other Patients Remind Me of the Perpetrator?”: Home-Based Telemedicine to Address Barriers to Care Unique to Military Sexual Trauma and Veterans Affairs Hospitals

PubMed Central

Gilmore, Amanda K.; Davis, Margaret T.; Grubaugh, Anouk; Resnick, Heidi; Birks, Anna; Denier, Carol; Muzzy, Wendy; Tuerk, Peter; Acierno, Ron

2016-01-01

Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barriers to care that are inherent to the treatment environment, such as with female veterans who have experienced military sexual trauma (MST) and who must present to VA Medical Centers where the majority of patients share features with perpetrator (e.g. gender, clothing) and may function as reminders of the trauma. Delivering evidence-based therapies to female veterans with MST-related PTSD via HBT can provide needed treatment to this population. This manuscript describes an ongoing federally funded randomized controlled trial comparing Prolonged Exposure (PE) delivered in-person to PE delivered via HBT. Outcomes include session attendance, satisfaction with services, and clinical and quality of life indices. It is hypothesized that based on intent-to-treat analyses, HBT delivery of PE will be more effective than SD at improving both clinical and quality of life outcomes at post, 3-, and 6-month follow-up. This is because ‘dose received’, that is fewer sessions missed, and lower attrition, will be observed in the HBT group. Although the current manuscript focuses on female veterans with MST-related PTSD, implications for other populations facing systemic barriers are discussed. PMID:26992740

"Do you expect me to receive PTSD care in a setting where most of the other patients remind me of the perpetrator?": Home-based telemedicine to address barriers to care unique to military sexual trauma and veterans affairs hospitals.

PubMed

Gilmore, Amanda K; Davis, Margaret T; Grubaugh, Anouk; Resnick, Heidi; Birks, Anna; Denier, Carol; Muzzy, Wendy; Tuerk, Peter; Acierno, Ron

2016-05-01

Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barriers to care that are inherent to the treatment environment, such as with female veterans who have experienced military sexual trauma (MST) and who must present to VA Medical Centers where the majority of patients share features with perpetrator (e.g. gender, clothing) and may function as reminders of the trauma. Delivering evidence-based therapies to female veterans with MST-related PTSD via HBT can provide needed treatment to this population. This manuscript describes an ongoing federally funded randomized controlled trial comparing Prolonged Exposure (PE) delivered in-person to PE delivered via HBT. Outcomes include session attendance, satisfaction with services, and clinical and quality of life indices. It is hypothesized that based on intent-to-treat analyses, HBT delivery of PE will be more effective than SD at improving both clinical and quality of life outcomes at post, 3-, and 6-month follow-up. This is because 'dose received', that is fewer sessions missed, and lower attrition, will be observed in the HBT group. Although the current manuscript focuses on female veterans with MST-related PTSD, implications for other populations facing systemic barriers are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Current State of Commercial Wearable Technology in Physical Activity Monitoring 2015-2017.

PubMed

Bunn, Jennifer A; Navalta, James W; Fountaine, Charles J; Reece, Joel D

2018-01-01

Wearable physical activity trackers are a popular and useful method to collect biometric information at rest and during exercise. The purpose of this systematic review was to summarize recent findings of wearable devices for biometric information related to steps, heart rate, and caloric expenditure for several devices that hold a large portion of the market share. Searches were conducted in both PubMed and SPORTdiscus. Filters included: humans, within the last 5 years, English, full-text, and adult 19+ years. Manuscripts were retained if they included an exercise component of 5-min or greater and had 20 or more participants. A total of 10 articles were retained for this review. Overall, wearable devices tend to underestimate energy expenditure compared to criterion laboratory measures, however at higher intensities of activity energy expenditure is underestimated. All wrist and forearm devices had a tendency to underestimate heart rate, and this error was generally greater at higher exercise intensities and those that included greater arm movement. Heart rate measurement was also typically better at rest and while exercising on a cycle ergometer compared to exercise on a treadmill or elliptical machine. Step count was underestimated at slower walking speeds and in free-living conditions, but improved accuracy at faster speeds. The majority of the studies reviewed in the present manuscript employed different methods to assess validity and reliability of wearable technology, making it difficult to compare devices. Standardized protocols would provide guidance for researchers to evaluate research-grade devices as well as commercial devices used by the lay public.

The relationship between manuscript title structure and success: editorial decisions and citation performance for an ecological journal

PubMed Central

Fox, Charles W; Burns, C Sean

2015-01-01

A poorly chosen article title may make a paper difficult to discover or discourage readership when discovered, reducing an article's impact. Yet, it is unclear how the structure of a manuscript's title influences readership and impact. We used manuscript tracking data for all manuscripts submitted to the journal Functional Ecology from 2004 to 2013 and citation data for papers published in this journal from 1987 to 2011 to examine how title features changed and whether a manuscript's title structure was predictive of success during the manuscript review process and/or impact (citation) after publication. Titles of manuscripts submitted to Functional Ecology became marginally longer (after controlling for other variables), broader in focus (less frequent inclusion of genus and species names), and included more humor and subtitles over the period of the study. Papers with subtitles were less likely to be rejected by editors both pre- and post-peer review, although both effects were small and the presence of subtitles in published papers was not predictive of citations. Papers with specific names of study organisms in their titles fared poorly during editorial (but not peer) review and, if published, were less well cited than papers whose titles did not include specific names. Papers with intermediate length titles were more successful during editorial review, although the effect was small and title word count was not predictive of citations. No features of titles were predictive of reviewer willingness to review papers or the length of time a paper was in peer review. We conclude that titles have changed in structure over time, but features of title structure have only small or no relationship with success during editorial review and post-publication impact. The title feature that was most predictive of manuscript success: papers whose titles emphasize broader conceptual or comparative issues fare better both pre- and post-publication than do papers with organism-specific titles. PMID:26045949

Bibliometric analysis of authorship trends and collaboration dynamics over the past three decades of BONE's publication history.

PubMed

Khan, Faisal; Sandelski, Morgan M; Rytlewski, Jeffrey D; Lamb, Jennifer; Pedro, Christina; Adjei, Michael B N; Lunsford, Shatoria; Fischer, James P; Wininger, Austin E; Whipple, Elizabeth C; Loder, Randall T; Kacena, Melissa A

2018-02-01

The existence of a gender gap in academia has been a hotly debated topic over the past several decades. It has been argued that due to the gender gap, it is more difficult for women to obtain higher positions. Manuscripts serve as an important measurement of one's accomplishments within a particular field of academia. Here, we analyzed, over the past 3 decades, authorship and other trends in manuscripts published in BONE, one of the premier journals in the field of bone and mineral metabolism. For this study, one complete year of manuscripts was evaluated (e.g. 1985, 1995, 2005, 2015) for each decade. A bibliometric analysis was then performed of authorship trends for those manuscripts. Analyzed fields included: average number of authors per manuscript, numerical position of the corresponding author, number of institutions collaborating on each manuscript, number of countries involved with each manuscript, number of references, and number of citations per manuscript. Each of these fields increased significantly over the 30-year time frame (p<10 -6 ). The gender of both the first and corresponding authors was identified and analyzed over time and by region. There was a significant increase in the percentage of female first authors from 23.4% in 1985 to 47.8% in 2015 (p=0.001). The percentage of female corresponding authors also increased from 21.2% in 1985 to 35.4% in 2015 although it was not significant (p=0.07). With such a substantial emphasis being placed on publishing in academic medicine, it is crucial to comprehend the changes in publishing characteristics over time and geographical region. These findings highlight authorship trends in BONE over time as well as by region. Importantly, these findings also highlight where challenges still exist. Copyright © 2017 Elsevier Inc. All rights reserved.

The relationship between manuscript title structure and success: editorial decisions and citation performance for an ecological journal.

PubMed

Fox, Charles W; Burns, C Sean

2015-05-01

A poorly chosen article title may make a paper difficult to discover or discourage readership when discovered, reducing an article's impact. Yet, it is unclear how the structure of a manuscript's title influences readership and impact. We used manuscript tracking data for all manuscripts submitted to the journal Functional Ecology from 2004 to 2013 and citation data for papers published in this journal from 1987 to 2011 to examine how title features changed and whether a manuscript's title structure was predictive of success during the manuscript review process and/or impact (citation) after publication. Titles of manuscripts submitted to Functional Ecology became marginally longer (after controlling for other variables), broader in focus (less frequent inclusion of genus and species names), and included more humor and subtitles over the period of the study. Papers with subtitles were less likely to be rejected by editors both pre- and post-peer review, although both effects were small and the presence of subtitles in published papers was not predictive of citations. Papers with specific names of study organisms in their titles fared poorly during editorial (but not peer) review and, if published, were less well cited than papers whose titles did not include specific names. Papers with intermediate length titles were more successful during editorial review, although the effect was small and title word count was not predictive of citations. No features of titles were predictive of reviewer willingness to review papers or the length of time a paper was in peer review. We conclude that titles have changed in structure over time, but features of title structure have only small or no relationship with success during editorial review and post-publication impact. The title feature that was most predictive of manuscript success: papers whose titles emphasize broader conceptual or comparative issues fare better both pre- and post-publication than do papers with organism-specific titles.

Exploring Specialized STEM High Schools: Three Dissertation Studies Examining Commonalities and Differences Across Six Case Studies

NASA Astrophysics Data System (ADS)

Tofel-Grehl, Colby

This dissertation is comprised of three independently conducted analyses of a larger investigation into the practices and features of specialized STEM high schools. While educators and policy makers advocate the development of many new specialized STEM high schools, little is known about the unique features and practices of these schools. The results of these manuscripts add to the literature exploring the promise of specialized STEM schools. Manuscript 1¹ is a qualitative investigation of the common features of STEM schools across multiple school model types. Schools were found to possess common cultural and academic features regardless of model type. Manuscript 2² builds on the findings of manuscript 1. With no meaningful differences found attributable to model type, the researchers used grounded theory to explore the relationships between observed differences among programs as related to the intensity of the STEM experience offered at schools. Schools were found to fall into two categories, high STEM intensity (HSI) and low STEM intensity (LSI), based on five major traits. Manuscript 3³ examines the commonalities and differences in classroom discourse and teachers' questioning techniques in STEM schools. It explicates these discursive practices in order to explore instructional practices across schools. It also examines factors that may influence classroom discourse such as discipline, level of teacher education, and course status as required or elective. Collectively, this research furthers the agenda of better understanding the potential advantages of specialized STEM high schools for preparing a future scientific workforce. ¹Tofel-Grehl, C., Callahan, C., & Gubbins, E. (2012). STEM high school communities: Common and differing features. Manuscript in preparation. ²Tofel-Grehl, C., Callahan, C., & Gubbins, E. (2012). Variations in the intensity of specialized science, technology, engineering, and mathematics (STEM) high schools. Manuscript in preparation. ³Tofel-Grehl, C., Callahan, C., & Gubbins, E. (2012). Comparative analyses of discourse in specialized STEM school classes. Manuscript in preparation.

A guide for digitising manuscript climate data

NASA Astrophysics Data System (ADS)

Brönnimann, S.; Annis, J.; Dann, W.; Ewen, T.; Grant, A. N.; Griesser, T.; Krähenmann, S.; Mohr, C.; Scherer, M.; Vogler, C.

2006-10-01

Hand-written or printed manuscript data are an important source for paleo-climatological studies, but bringing them into a suitable format can be a time consuming adventure with uncertain success. Before digitising such data (e.g., in the context a specific research project), it is worthwhile spending a few thoughts on the characteristics of the data, the scientific requirements with respect to quality and coverage, the metadata, and technical aspects such as reproduction techniques, digitising techniques, and quality control strategies. Here we briefly discuss the most important considerations according to our own experience and describe different methods for digitising numeric or text data (optical character recognition, speech recognition, and key entry). We present a tentative guide that is intended to help others compiling the necessary information and making the right decisions.

How do I write a scientific article?—A personal perspective

PubMed Central

2017-01-01

Scientific writing is not an easy task. Although there is no single and universally agreed strategy for assembling a successful scientific article, it is undeniable that some basic notions, gathered after decades of experience, may help increasing the chance of acceptance of a scientific manuscript. Therefore, the purpose of this article is to present a personal and arbitrary perspective on how to write a scientific article, entailing a tentative flowchart and a checklist describing the most important aspects characterizing each section of the manuscript. The final suggestion, which can be summarized in one simple and straightforward concept, is that you should always remember that a scientific article is meant to be read by others (i.e., referees and readers) and not by yourself. PMID:29152516

The Scientific Work of John A. McClelland: A Recently Discovered Manuscript

NASA Astrophysics Data System (ADS)

O'Connor, Thomas

2010-09-01

John Alexander McClelland (1870-1920) was educated at Queen’s College Galway and the Cavendish Laboratory in Cambridge. He was Professor of Experimental Physics at University College Dublin from 1900 to 1920. He was best known for his pioneering work on the scattering of β rays and on the conductivity of gases and the mobility of ions. He established a research school on atmospheric aerosols that was continued by his successor, John James Nolan (1887-1952), which strongly influenced physics research in Ireland up to the present. A recently discovered manuscript of a commemorative address by Nolan in 1920, which is reproduced in Appendix I, is a unique contemporary summary of McClelland’s research and character, and is an important contribution to the history of experimental physics in Ireland.

Good enough practices in scientific computing.

PubMed

Wilson, Greg; Bryan, Jennifer; Cranston, Karen; Kitzes, Justin; Nederbragt, Lex; Teal, Tracy K

2017-06-01

Computers are now essential in all branches of science, but most researchers are never taught the equivalent of basic lab skills for research computing. As a result, data can get lost, analyses can take much longer than necessary, and researchers are limited in how effectively they can work with software and data. Computing workflows need to follow the same practices as lab projects and notebooks, with organized data, documented steps, and the project structured for reproducibility, but researchers new to computing often don't know where to start. This paper presents a set of good computing practices that every researcher can adopt, regardless of their current level of computational skill. These practices, which encompass data management, programming, collaborating with colleagues, organizing projects, tracking work, and writing manuscripts, are drawn from a wide variety of published sources from our daily lives and from our work with volunteer organizations that have delivered workshops to over 11,000 people since 2010.

Search for neutrino oscillations in the MINOS experiment by using quasi-elastic interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piteira, Rodolphe

2005-09-29

The enthusiasm of the scientific community for studying oscillations of neutrinos is equaled only by the mass of their detectors. The MINOS experiment determines and compares the near spectrum of muonic neutrinos from the NUMI beam to the far one, in order to measure two oscillation parameters: Δmmore » $$2\\atop{23}$$ and sin 2 (2θ 23). The spectra are obtained by analyzing the charged current interactions which difficulty lies in identifying the interactions products (e.g. muons). An alternative method identifying the traces of muons, bent by the magnetic field of the detectors, and determining their energies is presented in this manuscript. The sensitivity of the detectors is optimal for the quasi-elastic interactions, for which a selection method is proposed, to study their oscillation. Even though it reduces the statistics, such a study introduces fewer systematic errors, constituting the ideal method on the long range.« less

Morbus Behçet - a rare disease in Central Europe.

PubMed

Woźniacka, Anna; Sysa-Jędrzejowska, Anna; Jurowski, Piotr; Jabłkowski, Maciej; Kot, Marek

2015-12-10

Behçet's disease (BD) is a multiorgan inflammatory disease of complex and not entirely elucidated etiology, which was originally diagnosed in patients with aphthous stomatitis, genital ulcerations and ocular manifestations. The entity is endemic in countries of Eastern and Central Asia, especially Turkey and Iran, but rarely seen in Central Europe. As there are no specific diagnostic laboratory tests or histopathologic findings which confirm the preliminary diagnosis, the final diagnosis should be based on clinical criteria. Frequently a definitive diagnosis is established within several years or months after the first manifestations appear. The increased number of cases, recently described worldwide also in the Polish population, indicates that the disease could spread out of endemic areas. The aim of this manuscript is to present the clinical picture, diagnosis criteria and therapeutic approaches of this "international disease" which currently is observed not only in emigrants from Asia but also in native Polish citizens.

THE CRIMINAL PSYCHOPATH: HISTORY, NEUROSCIENCE, TREATMENT, AND ECONOMICS

PubMed Central

Kiehl, Kent A.; Hoffman, Morris B.

2014-01-01

The manuscript surveys the history of psychopathic personality, from its origins in psychiatric folklore to its modern assessment in the forensic arena. Individuals with psychopathic personality, or psychopaths, have a disproportionate impact on the criminal justice system. Psychopaths are twenty to twenty-five times more likely than non-psychopaths to be in prison, four to eight times more likely to violently recidivate compared to non-psychopaths, and are resistant to most forms of treatment. This article presents the most current clinical efforts and neuroscience research in the field of psychopathy. Given psychopathy’s enormous impact on society in general and on the criminal justice system in particular, there are significant benefits to increasing awareness of the condition. This review also highlights a recent, compelling and cost-effective treatment program that has shown a significant reduction in violent recidivism in youth on a putative trajectory to psychopathic personality. PMID:24944437

Competitive counterion complexation allows the true host : guest binding constants from a single titration by ionic receptors.

PubMed

Pessêgo, Márcia; Basílio, Nuno; Muñiz, M Carmen; García-Río, Luis

2016-07-06

Counterion competitive complexation is a background process currently ignored by using ionic hosts. Consequently, guest binding constants are strongly affected by the design of the titration experiments in such a way that the results are dependent on the guest concentration and on the presence of added salts, usually buffers. In the present manuscript we show that these experimental difficulties can be overcome by just considering the counterion competitive complexation. Moreover a single titration allows us to obtain not only the true binding constants but also the stoichiometry of the complex showing the formation of 1 : 1 : 1 (host : guest : counterion) complexes. The detection of high stoichiometry complexes is not restricted to a single titration experiment but also to a displacement assay where both competitive and competitive-cooperative complexation models are taken into consideration.

QSAR modeling: where have you been? Where are you going to?

PubMed

Cherkasov, Artem; Muratov, Eugene N; Fourches, Denis; Varnek, Alexandre; Baskin, Igor I; Cronin, Mark; Dearden, John; Gramatica, Paola; Martin, Yvonne C; Todeschini, Roberto; Consonni, Viviana; Kuz'min, Victor E; Cramer, Richard; Benigni, Romualdo; Yang, Chihae; Rathman, James; Terfloth, Lothar; Gasteiger, Johann; Richard, Ann; Tropsha, Alexander

2014-06-26

Quantitative structure-activity relationship modeling is one of the major computational tools employed in medicinal chemistry. However, throughout its entire history it has drawn both praise and criticism concerning its reliability, limitations, successes, and failures. In this paper, we discuss (i) the development and evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) several novel and emerging applications of QSAR modeling. Throughout this discussion, we provide guidelines for QSAR development, validation, and application, which are summarized in best practices for building rigorously validated and externally predictive QSAR models. We hope that this Perspective will help communications between computational and experimental chemists toward collaborative development and use of QSAR models. We also believe that the guidelines presented here will help journal editors and reviewers apply more stringent scientific standards to manuscripts reporting new QSAR studies, as well as encourage the use of high quality, validated QSARs for regulatory decision making.

The role of time and time perspective in age-related processes: Introduction to the special issue.

PubMed

Fung, Helene H; Isaacowitz, Derek M

2016-09-01

There currently appears to be a general consensus on the relationship between time perspective and aging, such that (a) future time is perceived as more limited with age and (b) older people are more present-focused and less future-focused than younger people. At the same time, there are debates about whether these age differences are positively related to well-being and to what extent there are boundary conditions beyond which these age differences would cease to occur. The 8 manuscripts included in this Special Issue attempt to shed light on these debates. In doing so, they refine the dominant theoretical perspective on the topic-socioemotional selectivity theory-and introduce new theoretical perspectives. New measures and methodologies for studying time perspective and aging are also discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

QSAR Modeling: Where have you been? Where are you going to?

PubMed Central

Cherkasov, Artem; Muratov, Eugene N.; Fourches, Denis; Varnek, Alexandre; Baskin, Igor I.; Cronin, Mark; Dearden, John; Gramatica, Paola; Martin, Yvonne C.; Todeschini, Roberto; Consonni, Viviana; Kuz'min, Victor E.; Cramer, Richard; Benigni, Romualdo; Yang, Chihae; Rathman, James; Terfloth, Lothar; Gasteiger, Johann; Richard, Ann; Tropsha, Alexander

2014-01-01

Quantitative Structure-Activity Relationship modeling is one of the major computational tools employed in medicinal chemistry. However, throughout its entire history it has drawn both praise and criticism concerning its reliability, limitations, successes, and failures. In this paper, we discuss: (i) the development and evolution of QSAR; (ii) the current trends, unsolved problems, and pressing challenges; and (iii) several novel and emerging applications of QSAR modeling. Throughout this discussion, we provide guidelines for QSAR development, validation, and application, which are summarized in best practices for building rigorously validated and externally predictive QSAR models. We hope that this Perspective will help communications between computational and experimental chemists towards collaborative development and use of QSAR models. We also believe that the guidelines presented here will help journal editors and reviewers apply more stringent scientific standards to manuscripts reporting new QSAR studies, as well as encourage the use of high quality, validated QSARs for regulatory decision making. PMID:24351051

Conducting Research with Community Groups

PubMed Central

Doornbos, Mary Molewyk; Ayoola, Adejoke; Topp, Robert; Zandee, Gail Landheer

2016-01-01

Nurse scientists are increasingly recognizing the necessity of conducting research with community groups to effectively address complex health problems and successfully translate scientific advancements into the community. While several barriers to conducting research with community groups exist, community based participatory research (CBPR) has the potential to mitigate these barriers. CBPR has been employed in programs of research that respond in culturally sensitive ways to identify community needs and thereby address current health disparities. This manuscript presents case studies that demonstrate how CBPR principles guided the development of: (a) a healthy body weight program for urban, underserved African-American women, (b) a reproductive health educational intervention for urban, low-income, underserved, ethnically diverse women, and (c) a pilot anxiety/depression intervention for urban, low-income, underserved, ethnically diverse women. These case studies illustrate the potential of CBPR as an orientation to research that can be employed effectively in non-research intensive academic environments. PMID:25724557

Pancreatic cystic neoplasms: Review of current knowledge, diagnostic challenges, and management options

PubMed Central

Jana, Tanima; Shroff, Jennifer; Bhutani, Manoop S.

2015-01-01

Pancreatic cystic lesions are being detected with increasing frequency, largely due to advances in cross-sectional imaging. The most common neoplasms include serous cystadenomas, mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, solid pseudopapillary neoplasms, and cystic pancreatic endocrine neoplasms. Computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS) are currently used as imaging modalities. EUS-guided fine needle aspiration has proved to be a useful diagnostic tool, and enables an assessment of tumor markers, cytology, chemistries, and DNA analysis. Here, we review the current literature on pancreatic cystic neoplasms, including classification, diagnosis, treatment, and recommendations for surveillance. Data for this manuscript was acquired via searching the literature from inception to December 2014 on PubMed and Ovid MEDLINE. PMID:25821410

Biomedicine's Electronic Publishing Paradigm Shift

PubMed Central

Markovitz, Barry P.

2000-01-01

Biomedical publishing stands at a crossroads. The traditional print, peer-reviewed, subscription journal has served science well but is now being called into question. Because of spiraling print journal costs and the worldwide acceptance of the Internet as a valid publication medium, there is a compelling opportunity to re-examine our current paradigm and future options. This report illustrates the conflicts and restrictions inherent in the current publishing model and examines how the single act of permitting authors to retain copyright of their scholarly manuscripts may preserve the quality-control function of the current journal system while allowing PubMed Central, the Internet archiving system recently proposed by the director of the National Institutes of Health, to simplify and liberate access to the world's biomedical literature. PMID:10833158

FGK stars and T Tauri stars: Monograph series on nonthermal phenomena in stellar atmospheres

NASA Technical Reports Server (NTRS)

Cram, Lawrence E. (Editor); Kuhi, Leonard V. (Editor)

1989-01-01

The purpose of this book, FGK Stars and T Tauri Stars, like all other volumes of this series, is to exhibit and describe the best space data and ground based data currently available, and also to describe and critically evaluate the status of current theoretical models and physical mechanisms that have been proposed to interpret these data. The method for obtaining this book was to collect manuscripts from competent volunteer authors, and then to collate and edit these contributions to form a well structured book, which will be distributed to an international community of research astronomers by NASA and by the French CNRS.

Compressive Neuropathy of the Ulnar Nerve: A Perspective on History and Current Controversies.

PubMed

Eberlin, Kyle R; Marjoua, Youssra; Jupiter, Jesse B

2017-06-01

The untoward effects resulting from compression of the ulnar nerve have been recognized for almost 2 centuries. Initial treatment of cubital tunnel syndrome focused on complete transection of the nerve at the level of the elbow, resulting in initial alleviation of pain but significant functional morbidity. A number of subsequent techniques have been described including in situ decompression, subcutaneous transposition, submuscular transposition, and most recently, endoscopic release. This manuscript focuses on the historical aspects of each of these treatments and our current understanding of their efficacy. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Author! Author!: James E. Ransome.

ERIC Educational Resources Information Center

School Library Media Activities Monthly, 1996

1996-01-01

Presents a profile of James E. Ransome, a children's book illustrator. Highlights include his background, the influence of filmmaking in his storyboards, illustration as storytelling, manuscript selection, the use of models and realistic themes, awards, future work, and advice for librarians and teachers about how to use his books. (AEF)

HISTORY AND ACCOMPLISHMENTS OF THE US EPA'S SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION (SITE) MONITORING AND MEASUREMENT (MMT) PROGRAM

EPA Science Inventory

This manuscript presents the history and evolution of the U.S. Environmental Protection Agency's (EPA) Superfund Innovative Technology Evaluation (SITE) Monitoring and Measurement Technology (MMT) Program. This includes a discussion of how the fundamental concepts of a performanc...

ARS turns fifteen: la quinceañera bonita.

PubMed

Sen, Chandan K

2013-01-01

ARS was aimed at advancing the erstwhile niche field of redox biology to a more central position in research. Currently, ARS ranks first (impact factor: 8.456) in the field of redox biology. Of 8336 journals listed in Journal Citation Reports, ARS ranks 205th. The next journal in redox biology ranks 449th. ARS ranks 169th of 8336 in immediacy index. The next journal in redox biology ranks 923rd. Thus, ARS is the primary source of hot papers in redox sciences and healthcare. To grow footprint and overall impact, ARS has nearly doubled the annual publication volume from roughly 200 to 400 in one year. Because the manuscript volume represents the denominator of the impact factor calculation, such a sharp increase in volume would be predicted to a proportionally lower impact factor. Because of the robust current upward momentum, ARS will be affected less than that predicted by simple arithmetic and will maintain its top position even after such aggressive volume expansion. As another year passes, the additional manuscripts will get more time to be cited, and therefore the impact factor is expected to bounce back resulting in a much stronger journal with a substantially enhanced overall presence. ARS currently publishes 36 issues annually as two series: ARS-Discoveries, and ARS-Therapeutics. Redox biology does have the potential of major health impact. ARS-Therapeutics is the first and only forum dedicated to highlight that strength. I am grateful to the global redox village for their unreserved support to raise ARS and this fascinating field of redox research and healthcare. Antioxid. Redox Signal. 18, 1-4.

Deployment Family Stress: Child Neglect and Maltreatment in U.S. Army Families

DTIC Science & Technology

2012-10-01

for consideration of an article submission upon the completion of the analyses and written manuscript: (1) Ortho Psychiatry, (2) Child Abuse and...manuscript has been written, the following peer-reviewed journals will be considered for submission of the article: (1) Ortho Psychiatry, (2) Child Abuse and...three journals have been identified for consideration of the final manuscript submission, once it has been completed: (1) Ortho Psychiatry, (2) Child

Spatially tracking 13C labeled substrate (bicarbonate) accumulation in microbial communities using laser ablation isotope ratio mass spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moran, James J.; Doll, Charles G.; Bernstein, Hans C.

2014-08-25

This is a manuscript we would like to submit for publication in Environmental Microbiology Reports. This manuscript contains a description of a laser ablation isotope ratio mass spectrometry methodology developed at PNNL and applied to a microbial system at a PNNL project location – Hot Lake, Washington. I will submit a word document containing the entire manuscript with this Erica input request form.

Exposure pathway evaluations for sites that processed asbestos-contaminated vermiculite.

PubMed

Anderson, Barbara A; Dearwent, Steve M; Durant, James T; Dyken, Jill J; Freed, Jennifer A; Moore, Susan McAfee; Wheeler, John S

2005-01-01

The Agency for Toxic Substances and Disease Registry (ATSDR) is currently evaluating the potential public health impacts associated with the processing of asbestos-contaminated vermiculite at various facilities around the country. Vermiculite ore contaminated with significant levels of asbestos was mined and milled in Libby, Montana, from the early 1920s until 1990. The majority of the Libby ore was then shipped to processing facilities for exfoliation. ATSDR initiated the National Asbestos Exposure Review (NAER) to identify and evaluate exposure pathways associated with these processing facilities. This manuscript details ATSDR's phased approach in addressing exposure potential around these sites. As this is an ongoing project, only the results from a selected set of completed site analyses are presented. Historical occupational exposures are the most significant exposure pathway for the site evaluations completed to date. Former workers also probably brought asbestos fibers home on their clothing, shoes, and hair, and their household contacts may have been exposed. Currently, most site-related worker and community exposure pathways have been eliminated. One community exposure pathway of indeterminate significance is the current exposure of individuals through direct contact with waste rock brought home for personal use as fill material, driveway surfacing, or soil amendment. Trace levels of asbestos are present in soil at many of the sites and buried waste rock has been discovered at a few sites; therefore, future worker and community exposure associated with disturbing on-site soil during construction or redevelopment at these sites is also a potential exposure pathway.

Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017.

PubMed

von Haehling, Stephan; Morley, John E; Coats, Andrew J S; Anker, Stefan D

2017-12-01

This article details an updated version of the principles of ethical authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle (JCSM). At the time of submission to JCSM, the corresponding author, on behalf of all co-authors, needs to certify adherence to these principles. The principles are as follows: All authors listed on a manuscript considered for publication have approved its submission and (if accepted) publication as provided to JCSM. No person who has a right to be recognized as author has been omitted from the list of authors on the submitted manuscript. Each author has made a material and independent contribution to the work submitted for publication. The submitted work is original and is neither under consideration elsewhere nor that it has been published previously in whole or in part other than in abstract form. All authors certify that the work is original and does not contain excessive overlap with prior or contemporaneous publication elsewhere, and where the publication reports on cohorts, trials, or data that have been reported on before these other publications must be referenced. All original research work has been approved by the relevant bodies such as institutional review boards or ethics committees. All conflicts of interest, financial or otherwise, that may affect the authors' ability to present data objectively, and relevant sources of funding have been duly declared in the manuscript. The manuscript in its published form will be maintained on the servers of JCSM as a valid publication only as long as all statements in the guidelines on ethical publishing remain true. If any of the aforementioned statements ceases to be true, the authors have a duty to notify the Editors of JCSM as soon as possible so that the available information regarding the published article can be updated and/or the manuscript can be withdrawn. © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

Quantifying Federal Funding and Scholarly Output Related to the Academic Emergency Medicine Consensus Conferences

PubMed Central

Nishijima, Daniel K.; Dinh, Tu; May, Larissa; Yadav, Kabir; Gaddis, Gary M.; Cone, David C.

2014-01-01

Purpose Since 2000, Academic Emergency Medicine (AEM), the journal of the Society for Academic Emergency Medicine, has presented a one-day consensus conference to generate a research agenda for advancement of a scientific topic. One of the 12 annual issues of AEM is reserved for the proceedings of these conferences. The purpose of this study was to measure academic productivity of these conferences by evaluating subsequent federal research funding received by authors of conference manuscripts and calculating citation counts of conference papers. Method This was a cross-sectional study conducted during August and September 2012. NIH RePORTER was searched to identify subsequent federal funding obtained by authors of the consensus conference issues from 2000 to 2010. Funded projects were coded as related or unrelated to conference topic. Citation counts for all conference manuscripts were quantified using Scopus and Google Scholar. Simple descriptive statistics were reported. Results 852 individual authors contributed to 280 papers published in the 11 consensus conference issues. 137 authors (16%) obtained funding for 318 projects. A median of 22 topic-related projects per conference (range 10–97 projects) accounted for a median of $20,488,331 per conference (range $7,779,512–122,918,205). The average (±SD) number of citations per paper was 15.7 ±20.5 in Scopus and 23.7 ±32.6 in Google Scholar. Conclusions The authors of consensus conference manuscripts obtained significant federal grant support for follow-up research related to conference themes. In addition, the manuscripts generated by these conferences were frequently cited. Conferences devoted to research agenda development appear to be an academically worthwhile endeavor. PMID:24280853

"Why We Say No! A Look Through the Editor's Eye".

PubMed

Garg, Aarti; Das, Sunanda; Jain, Hemant

2015-10-01

The rapidly flourishing health science has provided a ground to perform research work and contribute to the field of science. On the other hand, reporting the research is equally important as carrying out research. Many such researches and their ground breaking work remain unreported or do not reach the guild, because of poor drafting skills. In nine years since Journal of Clinical and Diagnostic Research (JCDR) inception, editorial have come across many manuscripts which are clinically and socially relevant in their message, but lack legible drafting. It was felt that an objective analysis of the reasons for rejection, of manuscripts, is required. The present study was conducted with the aim to determine the reasons for rejection of medical and dental manuscript submitted in JCDR. Retrospective analysis of 1000 consecutive medical and dental articles submitted to JCDR since 1(st) August 2014 was done. Only those articles (902) that reached the end point on decision were considered. The reasons of rejection for medical and dental articles were enlisted and analyzed. When there were multiple reasons of rejection and all of them were critical, then they were counted in all the categories. Out of the 902 consecutive articles 522 articles underwent rejection. Among the rejected ones, dental specialty comprised of 43.5% and medical articles contributed 56.5%. The most frequent reasons for rejection were commonality (44.6%), non compliance by authors (17.8%), methodological issues (17.3%), plagiarism (11.1%), received same topic and published (7.66%), poor draft (6.70%), data inconsistency (5.77%), mismanagement (1.72%), blacklisted author (1.14%), ethical and out of scope were 0.57% each. Based on our findings, it can be concluded that manuscript rejection can be avoided by the authors, if the topic is well choosen and communication is maintained with the journal editorial.

Designing professional development to increase local capacity to sustain reform

NASA Astrophysics Data System (ADS)

Fogleman, Jay A.

There is a rich tradition of using curriculum materials to foster reform and innovation in science education. A key issue in any materials development effort is how to engender high-quality enactments of new materials, and how to sustain and scale up high-quality use so that the materials have a lasting and meaningful impact on the education of students. Many have argued that professional development (PD) is a key to the long-term success of systemic reform initiatives and there is a dire need for resources that help districts sustain PD opportunities that support teachers using innovations beyond their initial implementation. This dissertation consists of three manuscripts that look at the process of understanding teachers' use of reform-rich materials and supporting teacher professional development in the context of efforts by districts and innovators to implement and sustain their use in middle school science classrooms. The first manuscript looks specifically at the practices of teachers using learning-goals driven curriculum materials in an effort to model the effects of these practices on student achievement. Teacher surveys and video recording were used to relate teachers' characteristics and practices to student achievement using a multi-level approach. The second manuscript uses video recordings to critically examine a professional development workshop enacted by curriculum developers to identify knowledge and strategies that might be adapted for use locally to sustain PD offerings. The third manuscript presents two cases that describe how a professional development workcircle consisting of university researchers, district personnel, and lead teachers was able to sustain district-led professional development around reform-rich curriculum materials. Findings from the three studies are considered in light of factors necessary to sustain and scale the use of educational innovations and a model for supporting local PD is suggested.

The Diagnosis, Evaluation and Treatment of Acute and Recurrent Pediatric Urinary Tract Infections

PubMed Central

Becknell, Brian; Schober, Megan; Korbel, Lindsey; Spencer, John David

2015-01-01

Urinary tract infection is one of the most common bacterial infections encountered by pediatricians. Currently, the diagnosis and management of acute urinary tract infection and recurrent urinary tract infection in children remains controversial. Recently published guidelines and large clinical trials have attempted to clarify UTI diagnostic and management strategies. In this manuscript, we review the diagnosis and management of acute and recurrent urinary tract infection in the pediatric population. PMID:25421102

[Spot diagnosis of infectious exanthema].

PubMed

Ishiwada, Naruhiko

2007-03-01

There are lots of infectious diseases accompanied with exanthema. When the physicians see the patients with exanthema, they should carefully examine the form of exanthema and accessory symptoms. The physicians also should inquire of the patients about past history, history of vaccination and situation of current infectious disease epidemic in surrounding area. These clinical approaches lead to specific diagnosis. On this manuscript, I show the photos of several major infectious exanthema caused by viral, bacterial, bacterial toxin and so on.

Cognitive Enhancers for Anxiety Disorders

PubMed Central

Hofmann, Stefan G.; Smits, Jasper A. J.; Asnaani, Anu; Gutner, Cassidy A.; Otto, Michael W.

2010-01-01

Cognitive behavioral therapy is an effective intervention for anxiety disorders. However, a significant number of people do not respond or only show partial response even after an adequate course of the treatment. Recent research has shown that the efficacy of the intervention can be improved by the use of cognitive enhancers that augment the core learning processes of cognitive-behavior therapy. This manuscript provides a review of the current state of cognitive enhancers for the treatment of anxiety disorders. PMID:21134394

[Personalized medicine: equity and access].

PubMed

Joly, Yann; Knoppers, Bartha M

2014-11-01

Personalized medicine has seen a recent increase in popularity amongst medical researchers and policymakers. Nevertheless, there are persistent legal, ethical, and social questions that need to be explored, particularly related to the criticism that personalized medicine constitutes an elitist model of healthcare. Investigating this critique the current manuscript argues that personalized medicine has the potential to become a positive force for equitable access to better healthcare at a national and international level. © 2014 médecine/sciences – Inserm.

Improving Patient Care Through the Prism of Psychology: application of Maslow’s Hierarchy to Sedation, Delirium and Early Mobility in the ICU

PubMed Central

Jackson, James C.; Santoro, Michael J.; Ely, Taylor M.; Boehm, Leanne; Kiehl, Amy L; Anderson, Lindsay S.; Ely, E. Wesley

2016-01-01

The Intensive Care Unit is not only a place where lives are saved; it is also a site of harm and iatrogenic injury for millions of people treated in this setting globally every year. Increasingly, hospitals admit only the sickest patients, and, while the overall number of hospital beds remains stable in the U.S., the percentage of that total devoted to ICU beds is rising. These two realities engender a demographic imperative to address patient safety in the critical care setting. This manuscript addresses the medical community’s resistance to adopting a culture of safety in critical care with regard to issues surrounding sedation, delirium, and early mobility. Although there is currently much research and quality improvement in this area, most of what we know from these data and published guidelines has not become reality in the day-to-day management of ICU patients. This manuscript is not intended to provide a comprehensive review of the literature, but rather a framework to rethink our currently outdated culture of critical care by employing Maslow’s Hierarchy of Needs, along with a few novel analogies. Application of Maslow’s Hierarchy will help propel healthcare professionals toward comprehensive care of the whole person, not merely for survival, but toward restoration of pre-illness function of mind, body, and spirit. PMID:24636724

Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives.

PubMed

Salzano, Andrea; D'Assante, Roberta; Heaney, Liam M; Monaco, Federica; Rengo, Giuseppe; Valente, Pietro; Pasquali, Daniela; Bossone, Eduardo; Gianfrilli, Daniele; Lenzi, Andrea; Cittadini, Antonio; Marra, Alberto M; Napoli, Raffaele

2018-03-23

Klinefelter syndrome (KS), the most frequent chromosomic abnormality in males, is associated with hypergonadotropic hypogonadism and an increased risk of cardiovascular diseases (CVD). The mechanisms involved in increasing risk of cardiovascular morbidity and mortality are not completely understood. This review summarises the current understandings of the complex relationship between KS, metabolic syndrome and cardiovascular risk in order to plan future studies and improve current strategies to reduce mortality in this high-risk population. We searched PubMed, Web of Science, and Scopus for manuscripts published prior to November 2017 using key words "Klinefelter syndrome" AND "insulin resistance" OR "metabolic syndrome" OR "diabetes mellitus" OR "cardiovascular disease" OR "testosterone". Manuscripts were collated, studied and carried forward for discussion where appropriate. Insulin resistance, metabolic syndrome, and type 2 diabetes are more frequently diagnosed in KS than in the general population; however, the contribution of hypogonadism to metabolic derangement is highly controversial. Whether this dangerous combination of risk factors fully explains the CVD burden of KS patients remains unclear. In addition, testosterone replacement therapy only exerts a marginal action on the CVD system. Since fat accumulation and distribution seem to play a relevant role in triggering metabolic abnormalities, an early diagnosis and a tailored intervention strategy with drugs aimed at targeting excessive visceral fat deposition appear necessary in patients with KS.

Industrial Arts and Technology, Past, Present, and Future; Addresses and Proceedings of the American Industrial Arts Association's Annual Convention (29th, Philadelphia, 1967).

ERIC Educational Resources Information Center

American Industrial Arts Association, Washington, DC.

Manuscripts of 158 individual conference presentations are included. Speeches in each general session were centered on one of the following major topics--(1) Philosophical Bases of Industrial Arts--Four Poles, (2) Industrial Arts and the National Image, (3) The Cultural and Educational Heritage of Our Technological Society, (4) How and Where Can…

Editorial: The publication of geoscientific model developments v1.1

NASA Astrophysics Data System (ADS)

Executive Editors, GMD

2015-10-01

Version 1.0 of the editorial of the EGU (European Geosciences Union) journal, Geoscientific Model Development (GMD), was published in 2013. In that editorial an assessment was made of the progress the journal had made since it started, and some revisions to the editorial policy were introduced. After 2 years of experience with this revised editorial policy there are a few required updates, refinements and clarifications, so here we present version 1.1 of the editorial. The most significant amendments relate to the peer-review criteria as presented in the Framework for GMD manuscript types, which is published as an appendix to this paper and also available on the GMD manuscript types webpage. We also slightly refine and update the Publication guide and introduce a self-contained code and data policy. The changes are summarised as follows: - All manuscript types are now required to include code or data availability paragraphs, and model code must always be made available (in the case of copyright or other legal issues, to the editor at a minimum). - The role of evaluation in GMD papers is clarified, and a separate evaluation paper type is introduced. Model descriptions must already be published or in peer review when separate evaluation papers are submitted. - Observationally derived data should normally be published in a data journal rather than in GMD. Syntheses of data which were specifically designed for tasks such as model boundary conditions or direct evaluation of model output may, however, be published in GMD. - GMD publishes a broad range of different kinds of models, and this fact is now more explicitly acknowledged. - The main changes to the Publication guide are the addition of guidelines for editors when assessing papers at the initial review stage. Before sending papers for peer review, editors are required to make sure that papers comply with the Framework for GMD paper types and to carefully consider the topic of plagiarism. - A new appendix, the GMD code and data policy, is included. Version 1.1 of the manuscript types and Publication guide are included in the appendices with changed sentences marked in bold font.

Conversion of Plastic Surgery meeting abstract presentations to full manuscripts: a brazilian perspective.

PubMed

Denadai, Rafael; Pinho, André Silveira; Samartine, Hugo; Denadai, Rodrigo; Raposo-Amaral, Cassio Eduardo

2017-01-01

to assess the conversion rate of Plastic Surgery meeting abstract presentations to full manuscript publications and examine factors associated with this conversion. we assessed the abstracts presented at the 47th and 48th Brazilian Congresses of Plastic Surgery by cross-referencing with multiple databases. We analyzed the Abstracts' characteristics associated with full manuscript publications. of the 200 abstracts presented, 50 abstracts were subsequently published in full, giving the conference a conversion rate of 25%. The mean time to publish was 15.00±13.75 months. In total, there were 4.93±1.63 authors per abstract and 67.8±163 subjects per abstract; 43.5% of the abstracts were of retrospective studies; 69% comprised the plastic surgery topics head and neck, and chest and trunk, and 88.5% had no statistical analysis. Overall, 80% of the manuscripts were published in plastic surgery journals, 76% had no impact factor and 52% had no citations. Bivariate and multivariate analyses revealed the presence of statistical analysis to be the most significant (p<0.05) predictive factor of conversion of abstracts into full manuscripts. the conversion rate found from this bibliometric research appeared a bit lower than the conversion trend of international plastic surgery meetings, and statistical analysis was a determinant of conversion success. avaliar a taxa de conversão de resumos apresentados em congressos de Cirurgia Plástica em publicações de manuscritos completos e examinar fatores associados a essa conversão. resumos apresentados nos XLVII e XLVIII Congressos Brasileiros de Cirurgia Plástica foram avaliados por meio de referências cruzadas em diversos bancos de dados. Averiguaram-se as características dos resumos associadas às publicações de manuscritos completos. dos 200 resumos apresentados, 50 foram posteriormente publicados na íntegra, determinando uma taxa de publicação de 25%. O tempo médio para publicação foi 15,00±13,75 meses. No total, houve 4,93±1,63 autores/resumo e 67,8±163 pacientes/resumo; 43,5% dos resumos foram estudos retrospectivos; 69% pertenciam aos tópicos crânio, cabeça e pescoço, e tórax e tronco e 88,5% não apresentavam análise estatística. No geral, 80% dos manuscritos foram publicados em revistas de Cirurgia Plástica, 76% não exibiam fator de impacto e 52% não possuíam citações. As análises bivariada e multivariada revelaram que a presença de análise estatística foi o fator preditivo significativo (p<0,05) para a conversão de resumos em manuscritos completos. a taxa de conversão deste estudo bibliométrico foi inferior à tendência de conversão descrita em congressos internacionais de Cirurgia Plástica, e a presença de análise estatística foi um determinante para o sucesso de conversão.

TH-C-204-00: Medical Physics Workshop: An Update On the Journal’s Improvement Activities and Guidance On Writing and Reviewing Papers

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is “to continue the Journal’s tradition of publishing the very best science that propels ourmore » discipline forward and improves our contribution to patient care.” More concretely, the Journal should be the preeminent forum for exchange of cutting edge medical physics science. We seek to identify the best contributions in (a) high impact clinical physics innovations; (b) clinical translation and validation of basic science innovations; and (c) cutting edge basic science developments with potential for patient care improvements. Among the challenges and opportunities, we face are: electronic-only and open access publishing; competition from new radiological science journals; trends towards more interactive, social-media based scientific communities; and diversification of the medical physics research, authorship, and readership domains, including clinical applications quite foreign to core ABR clinical competencies. Recently implemented and ongoing initiatives include: Revised Table of Contents (TOC) and more contemporary topical submission categories Structured review template in HTML format Comprehensive hierarchical taxonomy for identifying reviewer expertise Formal process for soliciting high quality and impact Review and Vision 20/20 Articles We have recruited four Review Article Co-editors: John Rowlands and Ingrid Reiser (imaging physics) and Joao Seco and Tim Zhu (therapy physics). The Co-Editors will identify timely topics and solicit high profile authors to submit review manuscripts. To submit an article, authors will need to work with an assigned Co-Editor to develop a mutually acceptable outline and abstract. 5) A new and exciting class of articles: Medical Physics Dataset Articles (MPDAs) MPDAs describe scientifically or clinically valuable open-access datasets with high potential for contributing to the research of medical physicists working on related problems. In contrast to Research Articles, MPDAs should not include hypothesis testing; or data analyses supporting generalizable conclusions. The publically accessible dataset must be permanently archived before the MPDA can be published. This initiative is being led by Joe Deasy. Update on new publisher transition: The transition of AAPM scientific publishing operations to a major publishing house is a major opportunity to expand Medical Physics readership and its scholarly impact. The advantages include: (a) common manuscript management and web hosting platforms for Medical Physics and its sister journal, JACMP; (b) greater than 4-fold expansion of subscribing institutions; and (c) resources to mount data-driven, highly targeted marketing campaigns to enhance citation and download rates. A transition update of this epochal development, which has only begun as of this writing (3/31/16), will be given. Improving manuscript quality via structured reviews, enhanced scientific category taxonomy, and outreach: Shiva Das, Therapy Physics Editor Medical Physics is committed to continuous improvement with the ultimate goal of improving the potential impact of accepted manuscripts. In order to do so, Medical Physics must be able to tap into important/emerging areas and be able to select high quality contributions consistently via discerning reviews. Improving the quality of reviews is crucial to selecting high quality manuscripts and also to improving manuscript impact via feedback in the review process. With this in mind, Medical Physics is in the process of: (a) fostering outreach to important areas that are currently underrepresented in Medical Physics; (b) implementing a structured template review form; and (c) implementing a comprehensive scientific category taxonomy to identify reviewers who are best suited to an article. Outreach efforts have begun to various scientific areas. Strategies to increase submissions from these areas will be discussed. As a consequence of this effort, a special issue on particle therapy is under development. A review template was implemented in late 2014 on a limited test basis. Based on reviewer feedback, the template was restructured and shortened to capture essential review elements. The restructured template is due to be released shortly. The new scientific category taxonomy is in the process of being deployed to reviewers and associate editors. Salient aspects of the structured review template and scientific category taxonomy will be discussed in this talk. Writing good scientific papers and responding to critiques: Mitch Goodsitt, Imaging Physics Editor The essential components of the abstract, introduction, methods, discussion and conclusion sections of manuscripts, as well as the desired writing style and style of the figures and tables will be reviewed. Publishable Medical Physics manuscripts must include clear and concise statements of the novelty and clinical and/or scientific importance of the authors’ work. Examples of novelty include: new technical solution to an important clinical problem; new generalizable knowledge; and first demonstration that an existing engineering solution solves a clinical problem. Please note that we encourage authors of recently published conference proceedings (e.g., SPIE, IEEE) papers on novel medical physics related work to submit more substantial versions of that work to our journal. All submissions must include: sufficient background information and rationale; enough detail for others to reproduce the authors’ work; sufficient statistical analysis to refute or validate the authors’ hypotheses; a description of how the present work compares to, is distinct from, and improves upon others’ work; and sections devoted to the limitations of the study and future directions. Writing should be polished. Poor wording, grammar and composition frustrate the review process. Our journal does not have copyeditors for revising manuscripts. When authors receive critiques from the referees and associate editor, the authors should provide a detailed point-by-point response to each comment. The authors’ rebuttal should include the text of the original criticism, the authors’ response, and a pasted copy of the modified text along with the line numbers in the revised article. The new text should be highlighted in a different font color in the revised submission. Following these recommendations will improve submissions and facilitate the review process.« less

Transmission line component testing for the ITER Ion Cyclotron Heating and Current Drive System

NASA Astrophysics Data System (ADS)

Goulding, Richard; Bell, G. L.; Deibele, C. E.; McCarthy, M. P.; Rasmussen, D. A.; Swain, D. W.; Barber, G. C.; Barbier, C. N.; Cambell, I. H.; Moon, R. L.; Pesavento, P. V.; Fredd, E.; Greenough, N.; Kung, C.

2014-10-01

High power RF testing is underway to evaluate transmission line components for the ITER Ion Cyclotron Heating and Current Drive System. The transmission line has a characteristic impedance Z0 = 50 Ω and a nominal outer diameter of 305 mm. It is specified to carry up to 6 MW at VSWR = 1.5 for 3600 s pulses, with transient voltages up to 40 kV. The transmission line is actively cooled, with turbulent gas flow (N2) used to transfer heat from the inner to outer conductor, which is water cooled. High voltage and high current testing of components has been performed using resonant lines generating steady state voltages of 35 kV and transient voltages up to 60 kV. A resonant ring, which has operated with circulating power of 6 MW for 1 hr pulses, is being used to test high power, low VSWR operation. Components tested to date include gas barriers, straight sections of various lengths, and 90 degree elbows. Designs tested include gas barriers fabricated from quartz and aluminum nitride, and transmission lines with quartz and alumina inner conductor supports. The latest results will be presented. This manuscript has been authored by UT-Battelle, LLC, under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy.

Mechanical and chemical recycling of solid plastic waste.

PubMed

Ragaert, Kim; Delva, Laurens; Van Geem, Kevin

2017-11-01

This review presents a comprehensive description of the current pathways for recycling of polymers, via both mechanical and chemical recycling. The principles of these recycling pathways are framed against current-day industrial reality, by discussing predominant industrial technologies, design strategies and recycling examples of specific waste streams. Starting with an overview on types of solid plastic waste (SPW) and their origins, the manuscript continues with a discussion on the different valorisation options for SPW. The section on mechanical recycling contains an overview of current sorting technologies, specific challenges for mechanical recycling such as thermo-mechanical or lifetime degradation and the immiscibility of polymer blends. It also includes some industrial examples such as polyethylene terephthalate (PET) recycling, and SPW from post-consumer packaging, end-of-life vehicles or electr(on)ic devices. A separate section is dedicated to the relationship between design and recycling, emphasizing the role of concepts such as Design from Recycling. The section on chemical recycling collects a state-of-the-art on techniques such as chemolysis, pyrolysis, fluid catalytic cracking, hydrogen techniques and gasification. Additionally, this review discusses the main challenges (and some potential remedies) to these recycling strategies and ground them in the relevant polymer science, thus providing an academic angle as well as an applied one. Copyright © 2017 Elsevier Ltd. All rights reserved.

Development and Testing of Assessment Instruments for Multidisciplinary Engineering Capstone Design Courses

ERIC Educational Resources Information Center

Gerlick, Robert Edward

2010-01-01

The research presented in this manuscript was focused on the development of assessments for engineering design outcomes. The primary goal was to support efforts by the Transferrable Integrated Design Engineering Education (TIDEE) consortium in developing assessment instruments for multidisciplinary engineering capstone courses. Research conducted…

Bibliography of Journal Articles in Social Psychology: First Half of 1975.

ERIC Educational Resources Information Center

Capasso, Deborah R.; Hendrick, Clyde

The present bibliography updates three previous manuscripts which Hendrick helped develop. Articles from five journals are arranged alphabetically by heading and by author under 31 subject headings. The journals are Journal for the Theory of Social Behavior, Journal of Applied Social Psychology, Journal of Experimental Social Psychology, Journal…

Research Update: The USDA-ARS-Conservation and Production Research Laboratory, Bushland, Texas

USDA-ARS?s Scientific Manuscript database

This presentation/manuscript provide a brief summary of beef cattle feeding-related research conducted at the USDA-ARS-Conservation and Production Research Laboratory, Bushland, Texas, over the past four years. It summarizes data that has been published in scientific journals, in symposia and confer...

Proceedings of the Ninth International Vaccinium Symposium Vol. 1

USDA-ARS?s Scientific Manuscript database

The ISHS 9th International Vaccinium Symposium had 51 oral and 86 poster presentations. Scientists from 35 countries participated in the meeting. From these 120 manuscripts were published in this book. This book contains the state of blueberry research and breeding from a global view. Volume 1 conta...

Proceedings of the Ninth International Vaccinium Symposium Vol.2

USDA-ARS?s Scientific Manuscript database

The ISHS 9th International Vaccinium Symposium had 51 oral and 86 poster presentations. Scientists from 35 countries participated in the meeting. From these 120 manuscripts were published in this book. This book contains the state of blueberry research and breeding from a global view. Volume 2 conta...

Please Don't Aim for a Highly Cited Paper

ERIC Educational Resources Information Center

Calver, Michael C.

2015-01-01

Citation-based metrics are important in determining careers, so it is unsurprising that recent publications advise prospective authors on how to write highly cited papers. While such publications offer excellent advice on structuring and presenting manuscripts, there are significant downsides, including: restrictions in the topics researched,…

Nutritional management of feedlot cattle to optimize performance and minimize environmental impact

USDA-ARS?s Scientific Manuscript database

The cattle feeding industry is a new but rapidly growing industry in Brazil and other parts of South America. This presentation/ manuscript provides a brief overview of potential environmental issues faced by concentrated cattle feeding operations, and methods to minimize adverse effects on the envi...

The right to live or die? A perspective on voluntary euthanasia.

PubMed

Shah, Amber; Mushtaq, Ammara

2014-09-01

"It is choice alone that is being honored, without regards for what is chosen." The debate on euthanasia in medical community stays unresolved. In this manuscript, we present arguments for and against euthanasia, review arguments from both the sides and conclude it with our opinion.

You and Technology, A High School Case Study Text.

ERIC Educational Resources Information Center

Damaskos, Nickander J., Ed.; Smyth, Michael P., Ed.

This second draft of a manuscript for a high school engineering and technology course uses case studies as its format. The principles associated with various engineering problems are presented along with their effects on daily life. Topics include the computer, the automotive power system, satellite communications, the petroleum industry, water…

Molecular Determinants Fundamental to Axon Regeneration after SCI

DTIC Science & Technology

2014-09-01

mammalian spinal cord, axon regeneration is frustrated by inhibitors such as chondroitin sulfate proteoglycans (CSPGs) expressed by reactive astrocytes... chondroitin sulfates . Publications, Abstracts and Presentations: Publications: 1. Katerina Vajn, Jeffery A Plunkett, Alexis Tapanes...Jeffery A. Plunkett. Axonal growth of primary zebrafish brainstem neurons across inhibitory chondroitin sulfate proteoglycans. Manuscript in

Gene Expression Profiling of Androgen Receptor Antagonists Flutamide and Vinclozolin in Zebrafish (Danio rerio) Gonads

EPA Science Inventory

The studies presented in this manuscript focus on characterization of genomic responses to anti-androgens in zebrafish (Danio rerio). Research of the effects of anti-androgens in fish has been characterized by a heavy reliance on apical endpoints, and molecular mechanisms of acti...

Two Undergraduate Process Modeling Courses Taught Using Inductive Learning Methods

ERIC Educational Resources Information Center

Soroush, Masoud; Weinberger, Charles B.

2010-01-01

This manuscript presents a successful application of inductive learning in process modeling. It describes two process modeling courses that use inductive learning methods such as inquiry learning and problem-based learning, among others. The courses include a novel collection of multi-disciplinary complementary process modeling examples. They were…

Working Papers in Art Education, 1996-1997.

ERIC Educational Resources Information Center

Thunder-McGuire, Steve

1997-01-01

This collection of working papers in art education is comprised of manuscripts by graduate students presented at the National Art Education Conference. Papers in this issue reflect several educational settings and geographic areas. The 22 articles include: (1) "Symbolic Meanings in the Ghanaian Arts: A Step Towards Developing Cultural Literacy"…

RESEARCH REPORT ON THE RISK ASSESSMENT OF MIXTURES OF DISINFECTION BY-PRODUCTS (DBPS) IN DRINKING WATER

EPA Science Inventory

This report presents a number of manuscripts and progress reports on statistical and biological research pertaining to the health risk assessment of simple DBP mixtures. Research has been conducted to generate efficient experimental designs to test specific mixtures for departu...

Statistics as Unbiased Estimators: Exploring the Teaching of Standard Deviation

ERIC Educational Resources Information Center

Wasserman, Nicholas H.; Casey, Stephanie; Champion, Joe; Huey, Maryann

2017-01-01

This manuscript presents findings from a study about the knowledge for and planned teaching of standard deviation. We investigate how understanding variance as an unbiased (inferential) estimator--not just a descriptive statistic for the variation (spread) in data--is related to teachers' instruction regarding standard deviation, particularly…

Linear discrete systems with memory: a generalization of the Langmuir model

NASA Astrophysics Data System (ADS)

Băleanu, Dumitru; Nigmatullin, Raoul R.

2013-10-01

In this manuscript we analyzed a general solution of the linear nonlocal Langmuir model within time scale calculus. Several generalizations of the Langmuir model are presented together with their exact corresponding solutions. The physical meaning of the proposed models are investigated and their corresponding geometries are reported.

Religious Leaders' Perspectives on Marriage, Divorce, and Intimate Partner Violence

ERIC Educational Resources Information Center

Levitt, Heidi M.; Ware, Kimberly N.

2006-01-01

Religious leaders from Jewish, Christian, and Islamic faiths were interviewed about their understanding of the intersection of intimate partner violence (IPV) and religion, and a grounded-theory analysis was conducted. The present manuscript explored the leaders' beliefs about the partners' responsibility for IPV and the role of divorce. Although…

Tabletop Support for Collaborative Design: An Initial Evaluation of IdeaSpace

ERIC Educational Resources Information Center

Ioannou, Andri; Loizides, Fernando; Vasiliou, Christina; Zaphiris, Panayiotis; Parmaxi, Antigoni

2015-01-01

With the increasing availability of interactive tabletops, researchers and practitioners have the opportunity to expand the learning environment and provide further support for collaboration and reflective conversations around design problems. In this manuscript, we present IdeaSpace, a tabletop application designed to support collaborative design…

Examination of the Social Emotional Assessment Measure (SEAM) Parent-Toddler Interval

ERIC Educational Resources Information Center

Magee, Aoife Rose

2012-01-01

Parent-child relationships serve as the foundation for social emotional competence in young children. To support the healthy social emotional development of their children, parents may need to acquire information, resources, and skills through interventions that are based upon assessment of parent competence. This manuscript presents results from…

A Bibliography of Project Intrex Publications 1966-1973.

ERIC Educational Resources Information Center

Massachusetts Inst. of Tech., Cambridge. Electronic Systems Lab.

This bibliography lists journal articles, conference papers, book chapters, theses, and instructional aids written by the staff of Project Intrex at Massachusetts Institute of Technology. A listing of presentations given but not available in manuscript is also included. The publications listed report results of research sponsored by the National…

Cultural Institutions and Adult Education

ERIC Educational Resources Information Center

Taylor, Edward W.

2010-01-01

On any given day, hundreds of thousands of individuals, groups, and families visit libraries, parks, zoos, museums, and arboretums. Although quite diverse in their holdings, these places are linked together as institutions that focus on collecting, preserving, and/or presenting a body of knowledge (e.g., manuscripts, artifacts, documents, animals,…

Whiteness and absorbency of hydroentangled cotton-based nonwoven fabrics of different constituent fibers and fiber blends

USDA-ARS?s Scientific Manuscript database

This manuscript reports result of the research efforts devoted to the exploration and development of greige (non-bleached) cotton-containing nonwoven fabrics that likely could be made optimally competitive in cost, quality and performance to existing products that presently and predominantly use man...

Excelsior: Leadership in Teaching and Learning. Volume 1, Number 1, Fall/Winter 2006

ERIC Educational Resources Information Center

Lassonde, Cynthia A., Ed.

2006-01-01

"Excelsior: Leadership in Teaching and Learning" provides a forum to explore issues related to teaching and learning at public and independent colleges and universities with programs in teacher preparation. "Excelsior" solicits original, thought-provoking manuscripts of various formats, including papers presenting research on issues and practices…

STRUCTURE-ACTIVITY COMPARISON OF ORGANOTIN SPECIES: DIBUTYLTIN IS A DEVELOPMENTAL NEUROTOXICANT IN VITRO AND IN VIVO.

EPA Science Inventory

This manuscript compares the toxicity of a number of organotin species present in drinking water using a set of in vitro assays that model neuronal differentiation, and viability and apoptosis. Dibutyltin (DBT), dimethyltin (DMT), monomethyltin (MMT), and the positive control tri...

Measuring and Modeling Security and Privacy Laws

ERIC Educational Resources Information Center

Romanosky, Sasha

2012-01-01

This manuscript presents empirical and analytical analysis and discussion of security and privacy laws. The introduction, together with the three substantive chapters each represent separate research papers written as partial fulfillment of my PhD dissertation in the Heinz College, Carnegie Mellon University. Chapter 2 is an abbreviated version of…

A SCREENING MODEL FOR SIMULATING DNAPL FLOW AND TRANSPORT IN POROUS MEDIA: THEORETICAL DEVELOPMENT

EPA Science Inventory

There exists a need for a simple tool that will allow us to analyze a DNAPL contamination scenario from free-product release to transport of soluble constituents to downgradient receptor wells. The objective of this manuscript is to present the conceptual model and formulate the ...

A review of illicit psychoactive drug use in elective surgery patients: Detection, effects, and policy.

PubMed

Selvaggi, Gennaro; Spagnolo, Antonio G; Elander, Anna

2017-12-01

Limited information is present in literature regarding detection of illicit drug users visiting physicians when planning elective surgery; also, there is no update manuscript that is illustrating the effects of illicit drugs use that require reconstructive surgery interventions. Aims of this manuscript are: 1) to summarize existing knowledge, and give surgeons information how to detect patients who might possible use illicit drugs; 2) to review the effects of illicit drug use that specifically require reconstructive surgery interventions; 3) to assess on existing policies on asymptomatic illicit drug users when planning elective surgery. Studies were identified by searching systematically in the electronic databases PubMed, Medline, The Cochrane Library and SveMed+. Because of the nature of research questions to be investigated (drug policy and surgery), a "systematic review" was not possible. In spite of some existing policies to detect illicit drug use in specific situations such as workplaces or acute trauma patients, there is a lack of data and lack of information, and subsequently no policy has ever been made, for detection and management of illicit drug use asymptomatic patients requesting or referred for plastic surgery interventions. This manuscript poses questions for further ethical evaluations and future policy. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

Characterizing the Intrinsic Fluorescence Properties of Historical Painting Materials: The Case Study of a Sixteenth-Century Mesoamerican Manuscript.

PubMed

Pottier, Fabien; Michelin, Anne; Andraud, Christine; Goubard, Fabrice; Lavédrine, Bertrand

2018-04-01

Ultraviolet visible (UV-Vis) fluorescence spectroscopy is widely used to study polychrome objects and can help to identify the nature of certain materials when they present specific fluorescent properties. However, given the complexity of the stratified and heterogeneous materials under study, the characterization of an intrinsic fluorescence related to a given constituent (a pigment or a binder composing a paint layer for example) is not straightforward, and the recorded raw data need to be corrected for a number of effects that can influence the detected spectral distribution. The application of standard correction procedures to experimental fluorescence data gathered on the polychromatic surface of the Codex Borbonicus, a 16th-century Aztec manuscript, is described. The results are confronted to an alternate new methodology that is based on the hypothesis of transparent non-scattering paint layers. This second approach allows to establish more clearly the material origin of the detected emission and to discriminate apparent fluorescence (emitted by the substrate and transmitted through the paint layers) from actual intrinsic emission generated by the coloring materials under study. The results show that most of the various emission profiles detected in the paint layers of the manuscript actually originate from a unique fluorophore (composing the substrate) and should not be used to characterize the coloring materials.

Employer Policies and Practices to Manage and Prevent Disability: Foreword to the Special Issue.

PubMed

Shaw, William S; Main, Chris J; Pransky, Glenn; Nicholas, Michael K; Anema, Johannes R; Linton, Steven J

2016-12-01

Purpose Employer policies and practices have been shown to impact workplace disability, but research in this area has waned in recent years despite an aging workforce, a growing prevalence of chronic health conditions, and a larger proportion of working-age adults on permanent work disability in many jurisdictions. The purpose of this article is to describe the background rationale and methodology for an invited conference designed to improve research of employer strategies to curtail work disability. Methods A multidisciplinary team of 26 international researchers with published research in employer-based disability management or related fields were invited to attend a 3-day conference in Hopkinton, Massachusetts, USA. The overall goal was to review the status of current research of workplace disability management and prevention, examine its relevance for employer decision-making, compare conceptual frameworks or theoretical perspectives, and recommend future research directions. Working groups were organized and draft manuscripts were prepared in advance. Conference activities included working group presentations and critiques, discussions with a panel of industry consultants and advisors, group interaction and debate, generation of final recommendations, and manuscript revision. Results/Conclusion Six principal domains were established with respect to future research: (a) further elucidation of the key workplace factors that buffer the disabling effects of injury and illness; (b) more innovative and feasible options for workplace intervention; (c) measurement of workplace-relevant disability outcomes; (d) a stronger theoretical framework for understanding the factors behind employer uptake and implementation; (e) a focus on special clinical populations and occupations where disability risk is most troubling; and (f) better representation of workers and employers that reflect the diverse and changing nature of work. Final comments and recommendations of the working groups are presented in the following six articles in this special issue of the Journal of Occupational Rehabilitation. Conference attendees recommended changes in methodology, collaboration strategies, and theoretical perspectives to improve the practical and scientific impact of future research of employer practices.

Medical Mucilage Used in Traditional Persian Medicine Practice

PubMed Central

Heydarirad, Ghazaleh; Choopani, Rasool; Mehdi, Pasalar; Jafari, Jamileh Mahdavi

2016-01-01

Background: Mucilage compounds are pharmaceutically important polysaccharides that have an extensive range of applications, including binding agents, thickeners, water retention agents, emulsion stabilizers, suspending agents, disintegrates, film formers, and gelling agents. A historical approach to medical science written by Iranian scholars could help in identifying excellent ideas and provide valuable information in this field for proper application. The aim of the current study was to introduce some mucilage uses derived from traditional Persian medicine (TPM). Methods: In this literature review, we assessed a few main traditional manuscripts of Iranian medicine, including the books Al Havi, Canon of Medicine, Qarabadine-kabir, Zakhireh-ye Khwarazm shahi, Tuhfat ul-Momineen and Makhzan-ul-Adwiah. The word “loab” in the aforementioned books were searched and all data about mucilage compounds were collected. Results: The use of medicinal plants containing mucilage in Iran dates back to ancient times. In traditional Persian manuscripts, mucilage is one of the most cited applications of medicinal plants for therapeutic objectives. There are various mucilage-producing plants in TPM such as Malva silvestris, Linum usitissimum, Althaea officinalis, Plantago psyllium, Descureania sophia and Ziziphus vulgaris. They have been used traditionally via oral or topical routes for respiratory, gastrointestinal, urinary, musculoskeletal, and genital systems as well as skin disorders. Certain applications are unique and promising for today’s chronic ailments. Conclusion: A scientific assessment of these valuable manuscripts would provide a better insight into the thoughts of the past sages and applicable for clinical use of the mucilage compounds. This may lead to research opportunities in the future. PMID:27516674

Medical Mucilage Used in Traditional Persian Medicine Practice

PubMed Central

Heydarirad, Ghazaleh; Choopani, Rasool; Mehdi, Pasalar; Jafari, Jamileh Mahdavi

2016-01-01

Background: Mucilage compounds are pharmaceutically important polysaccharides that have an extensive range of applications, including binding agents, thickeners, water retention agents, emulsion stabilizers, suspending agents, disintegrates, film formers, and gelling agents. A historical approach to medical science written by Iranian scholars could help in identifying excellent ideas and provide valuable information in this field for proper application. The aim of the current study was to introduce some mucilage uses derived from traditional Persian medicine (TPM). Methods: In this literature review, we assessed a few main traditional manuscripts of Iranian medicine, including the books Al Havi, Canon of Medicine, Qarabadine-kabir, Zakhireh-ye Khwarazm shahi, Tuhfat ul-Momineen and Makhzan-ul-Adwiah. The word “loab” in the aforementioned books were searched and all data about mucilage compounds were collected. Results: The use of medicinal plants containing mucilage in Iran dates back to ancient times. In traditional Persian manuscripts, mucilage is one of the most cited applications of medicinal plants for therapeutic objectives. There are various mucilage-producing plants in TPM such as Malva silvestris, Linum usitissimum, Althaea officinalis, Plantago psyllium, Descureania sophia and Ziziphus vulgaris. They have been used traditionally via oral or topical routes for respiratory, gastrointestinal, urinary, musculoskeletal, and genital systems as well as skin disorders. Certain applications are unique and promising for today’s chronic ailments. Conclusion: A scientific assessment of these valuable manuscripts would provide a better insight into the thoughts of the past sages and applicable for clinical use of the mucilage compounds. This may lead to research opportunities in the future. PMID:27840507

"On-screen" writing and composing: two years experience with Manuscript Manager, Apple II and IBM-PC versions.

PubMed

Offerhaus, L

1989-06-01

The problems of the direct composition of a biomedical manuscript on a personal computer are discussed. Most word processing software is unsuitable because literature references, once stored, cannot be rearranged if major changes are necessary. These obstacles have been overcome in Manuscript Manager, a combination of word processing and database software. As it follows Council of Biology Editors and Vancouver rules, the printouts should be technically acceptable to most leading biomedical journals.

Validation and Interrogation of Differentially Expressed and Alternatively Spliced Genes in African American Prostate Cancer

DTIC Science & Technology

2016-10-01

These analyses have led to two submitted manuscripts. The first manuscript, “Variants of stemness -related genes predicted to regulate RNA splicing...and Table 1-3 at the end of this progress report. The second manuscript, “Single nucleotide polymorphisms of stemness pathway genes predicted to...cancer and support a contribution of the stemness pathway to prostate cancer patient outcome. Please see Figure 5-7 and Table 4-6 at the end of this

A Case of Chagas Cardiomyopathy Following Infection in South Central Texas

DTIC Science & Technology

2017-05-24

author(s), title, etc.) has been entered into our computer file. Please advise us (by phone or mail) that your presentation was given. At that time , we...and time . Your contributions are vital to the medical mission. We look forward to assisting you in your future publication/presentation efforts...letter of approval or disapproval. 9. Once your manuscript, poster or presentation has been approved for a one- time public release, you may proceed with

Obesity and Headache: Part I – A Systematic Review of the Epidemiology of Obesity and Headache

PubMed Central

Chai, Nu Cindy; Scher, Ann I.; Moghekar, Abhay; Bond, Dale S.; Peterlin, B. Lee

2014-01-01

Individually, both obesity and headache are conditions associated with a substantial personal and societal impact. Recent data support that obesity is comorbid with headache in general and migraine specifically, as well as with certain secondary headache conditions such as idiopathic intracranial hypertension. In the current manuscript, we first briefly review the epidemiology of obesity and common primary and secondary headache disorders individually. This is followed by a systematic review of the general population data evaluating the association between obesity and headache in general, and then obesity and migraine and tension-type headache disorders. Finally, we briefly discuss the data on the association between obesity and a common secondary headache disorder that is associated with obesity, idiopathic intracranial hypertension. Taken together, these data suggest that it is important for clinicians and patients to be aware of the headache/migraine-obesity association, given that it is potentially modifiable. Hypotheses for mechanisms of the obesity-migraine association and treatment considerations for overweight and obese headache sufferers are discussed in the companion manuscript, as part II of this topic. PMID:24512574

Biosimilar Products in the Modern U.S. Health Care and Regulatory Landscape.

PubMed

Peterson, Jesse; Budlong, Holly; Affeldt, Tim; Skiermont, Kyle; Kyllo, Gregg; Heaton, Al

2017-12-01

Biosimilars have the potential to greatly reduce medication costs in the United States. As of July 1, 2017, 5 biosimilars have been approved by the FDA, but only 2 are available for purchase. This commentary outlines the efforts of an integrated health system to ensure biosimilar accessibility and discusses the current challenges and future implications. We highlight the implementation of a health plan policy and how a health system's formulary committee can encourage use while considering provider perceptions and operational challenges. In addition, we provide our perspective on potential implications for pricing, site of care, and pharmacy dispensing practices based on our experience with regulatory hurdles and market trends. Overall, we believe biosimilars are a good thing for the health care system, but their expected benefit may not be realized for years to come. No outside funding supported this work. Affeldt reports advisory board membership with Janssen, and Skiermont reports membership with Amgen and McKesson. The other authors have nothing to disclose. Peterson and Budlong contributed the study concept and design and wrote the manuscript. Affeldt, Skiermont, Kyllo, and Heaton reviewed and revised the manuscript.

A combined approach for the attribution of handwriting: the case of Antonio Stradivari's manuscripts

NASA Astrophysics Data System (ADS)

Fichera, Giusj Valentina; Dondi, Piercarlo; Licchelli, Maurizio; Lombardi, Luca; Ridolfi, Stefano; Malagodi, Marco

2016-11-01

Numerous artefacts from Antonio Stradivari's workshop are currently preserved in the "Museo del Violino" (Museum of the Violin) in Cremona, Italy. A large number of them are paper models containing instructions and technical notes by the great violin maker. After his death, this collection has had several owners, while new annotations added to the original ones, sometimes imitating Stradivari's handwriting, caused problems of authenticity. The attribution of these relics is a complex task and, until now, only a small part of them has been examined by palaeographers. This paper introduces a multi-analytical approach able to facilitate the study of handwriting in manuscripts with the combined use of image processing and X-ray fluorescence spectroscopy: the former provides a fast and automatic screening of documents; the latter allows to analyse the chemical composition of inks. For our tests, 17 paper relics, dated between 1684 and 1729, were chosen. Palaeographic analysis was used as reference. The results obtained showed the validity of the combined approach proposed herein: the two techniques proved to be complementary and useful to clarify the attribution of different pieces of handwriting.

Implementation science: a reappraisal of our journal mission and scope.

PubMed

Foy, Robbie; Sales, Anne; Wensing, Michel; Aarons, Gregory A; Flottorp, Signe; Kent, Bridie; Michie, Susan; O'Connor, Denise; Rogers, Anne; Sevdalis, Nick; Straus, Sharon; Wilson, Paul

2015-04-17

The implementation of research findings into healthcare practice has become increasingly recognised as a major priority for researchers, service providers, research funders and policymakers over the past decade. Nine years after its establishment, Implementation Science, an international online open access journal, currently publishes over 150 articles each year. This is fewer than 30% of those submitted for publication. The majority of manuscript rejections occur at the point of initial editorial screening, frequently because we judge them to fall outside of journal scope. There are a number of common reasons as to why manuscripts are rejected on grounds of scope. Furthermore, as the field of implementation research has evolved and our journal submissions have risen, we have, out of necessity, had to become more selective in what we publish. We have also expanded our scope, particularly around patient-mediated and population health interventions, and will monitor the impact of such changes. We hope this editorial on our evolving priorities and common reasons for rejection without peer review will help authors to better judge the relevance of their papers to Implementation Science.

Multifunctional nanoplatforms for targeted multidrug-resistant-bacteria theranostic applications.

PubMed

Dai, Xuemei; Fan, Zhen; Lu, Yuefeng; Ray, Paresh Chandra

2013-11-13

The emergence of multidrug-resistant-bacteria (MDRB) infection poses a major burden to modern healthcare. Early detection in the bloodstream and a new strategy development for MDRB infection treatment without antibiotics are clinically significant to save millions of lives every year. To tackle the MDRB challenge, the current manuscript reports the design of "multifunctional nanoplatforms" consisting of a magnetic core-plasmonic shell nanoparticle, a methylene blue-bound aptamer, and an MDRB Salmonella DT104 specific antibody. The reported "multifunctional nanoplatform" is capable of targeted separation from a blood sample and sensing and multimodal therapeutic killing of MDRB. Experimental data using an MDRB-infected whole-blood sample show that nanoplatforms can be used for selective magnetic separation and fluorescence imaging. In vitro light-triggered photodestruction of MDRB, using combined photodynamic and photothermal treatment, shows that the multimodal treatment regime can enhance MDRB killing significantly. We discussed the possible mechanisms on combined synergistic therapy for killing MDRB. The "multifunctional nanoplatform" reported in this manuscript has great potential for the imaging and combined therapy of MDRB in clinical settings.

Review of key concepts in magnetic resonance physics.

PubMed

Moore, Michael M; Chung, Taylor

2017-05-01

MR physics can be a challenging subject for practicing pediatric radiologists. Although many excellent texts provide very comprehensive reviews of the field of MR physics at various levels of understanding, the authors of this paper explain several key concepts in MR physics that are germane to clinical practice in a non-rigorous but practical fashion. With the basic understanding of these key concepts, practicing pediatric radiologists can build on their knowledge of current clinical MR techniques and future advances in MR applications. Given the challenges of both the increased need for rapid imaging in non-sedated children and the rapid physiological cardiovascular and respiratory motion in pediatric patients, many advances in complex MR techniques are being applied to imaging these children. The key concepts are as follows: (1) structure of a pulse sequence, (2) k-space, (3) "trade-off triangle" and (4) fat suppression. This review is the first of five manuscripts in a minisymposium on pediatric MR. The authors' goal for this review is to aid in understanding the MR techniques described in the subsequent manuscripts on brain imaging and body imaging in this minisymposium.

Recommendations for the evaluation of specimen stability for flow cytometric testing during drug development.

PubMed

Brown, Lynette; Green, Cherie L; Jones, Nicholas; Stewart, Jennifer J; Fraser, Stephanie; Howell, Kathy; Xu, Yuanxin; Hill, Carla G; Wiwi, Christopher A; White, Wendy I; O'Brien, Peter J; Litwin, Virginia

2015-03-01

The objective of this manuscript is to present an approach for evaluating specimen stability for flow cytometric methods used during drug development. While this approach specifically addresses stability assessment for assays to be used in clinical trials with centralized testing facilities, the concepts can be applied to any stability assessment for flow cytometric methods. The proposed approach is implemented during assay development and optimization, and includes suggestions for designing a stability assessment plan, data evaluation and acceptance criteria. Given that no single solution will be applicable in all scenarios, this manuscript offers the reader a roadmap for stability assessment and is intended to guide the investigator during both the method development phase and in the experimental design of the validation plan. Copyright © 2015 Elsevier B.V. All rights reserved.

Retraction notice to "Sapphirine and fluid inclusions in Tel Thanoun mantle xenoliths, Syria" [J. Afr. Earth Sci. 116 (2015) 105-113

NASA Astrophysics Data System (ADS)

Bilal, Ahmad

2018-06-01

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor. Following complaints raised, it appears to be a reworking of a former manuscript submitted by a group of five authors but not published. The present author has published here alone, without acknowledging the work of the four other co-authors of the initial submission. This poses a problem of integrity as this new article contains material which was submitted for publication initially by all five authors. By retracting this article, we encourage all the authors of the initial manuscript to resubmit together a new version which respects authorship and scientific integrity.

Three-dimensional kinematics of the lumbar spine during gait using marker-based systems: a systematic review.

PubMed

Needham, Robert; Stebbins, Julie; Chockalingam, Nachiappan

2016-01-01

To review the current scientific literature on the assessment of three-dimensional movement of the lumbar spine with a focus on the utilisation of a 3D cluster. Electronic databases PubMed, OVID, CINAHL, The Cochrance Library, ScienceDirect, ProQuest and Web of Knowledge were searched between 1966 and March 2015. The reference lists of the articles that met the inclusion criteria were also searched. From the 1530 articles identified through an initial search, 16 articles met the inclusion criteria. All information relating to methodology and kinematic modelling of the lumbar segment along with the outcome measures were extracted from the studies identified for synthesis. Guidelines detailing 3D cluster construction were limited in the identified articles and the lack of information presented makes it difficult to assess the external validity of this technique. Scarce information was presented detailing time-series angle data of the lumbar spine during gait. Further developments of the 3D cluster technique are required and it is essential that the authors provide clear instruction, definitions and standards in their manuscript to improve clarity and reproducibility.

Managing Groundwater Radioactive Contamination at the Daiichi Nuclear Plant

PubMed Central

Marui, Atsunao; Gallardo, Adrian H.

2015-01-01

The Great East Japan Earthquake and tsunami of March 2011 severely damaged three reactors at the Fukushima Daiichi nuclear power station, leading to a major release of radiation into the environment. Groundwater flow through these crippled reactors continues to be one of the main causes of contamination and associated transport of radionuclides into the Pacific Ocean. In this context, a number of strategies are being implemented to manage radioactive pollution of the water resources at the nuclear plant site. Along with water treatment and purification, it is critical to restrict the groundwater flow to and from the reactors. Thus, the devised strategies combine walls containment, bores abstraction, infiltration control, and the use of tanks for the temporary storage of contaminated waters. While some of these techniques have been previously applied in other environments, they have never been tested at such a large scale. Therefore, their effectiveness remains to be seen. The present manuscript presents an overview of the methods being currently implemented to manage groundwater contamination and to mitigate the impact of hydrological pathways in the dispersion of radionuclides at Fukushima. PMID:26197330

Managing Groundwater Radioactive Contamination at the Daiichi Nuclear Plant.

PubMed

Marui, Atsunao; Gallardo, Adrian H

2015-07-21

The Great East Japan Earthquake and tsunami of March 2011 severely damaged three reactors at the Fukushima Daiichi nuclear power station, leading to a major release of radiation into the environment. Groundwater flow through these crippled reactors continues to be one of the main causes of contamination and associated transport of radionuclides into the Pacific Ocean. In this context, a number of strategies are being implemented to manage radioactive pollution of the water resources at the nuclear plant site. Along with water treatment and purification, it is critical to restrict the groundwater flow to and from the reactors. Thus, the devised strategies combine walls containment, bores abstraction, infiltration control, and the use of tanks for the temporary storage of contaminated waters. While some of these techniques have been previously applied in other environments, they have never been tested at such a large scale. Therefore, their effectiveness remains to be seen. The present manuscript presents an overview of the methods being currently implemented to manage groundwater contamination and to mitigate the impact of hydrological pathways in the dispersion of radionuclides at Fukushima.

Elucidating the oxide growth mechanism on platinum at the cathode in PEM fuel cells.

PubMed

Redmond, Erin L; Setzler, Brian P; Alamgir, Faisal M; Fuller, Thomas F

2014-03-21

Simulations of platinum oxidation in literature have yet to fully replicate an experimental cyclic voltammogram. In this manuscript a mechanism for platinum oxidation is proposed based upon the results of in operando X-ray absorption spectroscopy, where it was found that PtO2 is present at longer hold times. A new method to quantify extended X-ray absorption fine structure data is presented, and the extent of oxidation is directly compared to electrochemical data. This comparison indicated that PtO2 was formed at the expense of an initial oxide species. From previous literature studies it can be concluded that the rate of platinum oxidation is not a function of only potential and coverage. To that end, the concept of a heterogeneous oxide layer was introduced into the model, whereby place-exchanged PtO2 structures of varying energy states are formed through a single transition state. This treatment allowed, for the first time, the simulation of the correct current-potential behavior at varying scan rates and upper potential limits.

Warping an atlas derived from serial histology to 5 high-resolution MRIs.

PubMed

Tullo, Stephanie; Devenyi, Gabriel A; Patel, Raihaan; Park, Min Tae M; Collins, D Louis; Chakravarty, M Mallar

2018-06-19

Previous work from our group demonstrated the use of multiple input atlases to a modified multi-atlas framework (MAGeT-Brain) to improve subject-based segmentation accuracy. Currently, segmentation of the striatum, globus pallidus and thalamus are generated from a single high-resolution and -contrast MRI atlas derived from annotated serial histological sections. Here, we warp this atlas to five high-resolution MRI templates to create five de novo atlases. The overall goal of this work is to use these newly warped atlases as input to MAGeT-Brain in an effort to consolidate and improve the workflow presented in previous manuscripts from our group, allowing for simultaneous multi-structure segmentation. The work presented details the methodology used for the creation of the atlases using a technique previously proposed, where atlas labels are modified to mimic the intensity and contrast profile of MRI to facilitate atlas-to-template nonlinear transformation estimation. Dice's Kappa metric was used to demonstrate high quality registration and segmentation accuracy of the atlases. The final atlases are available at https://github.com/CobraLab/atlases/tree/master/5-atlas-subcortical.

[New studies on the history of anesthesiology--a new study on Seishu Hanaoka's "Nyugan Ckiken Roku" (a surgical experience with breast cancer)].

PubMed

Matsuki, A

2000-09-01

Among Japanese physicians before the Edo era, Seishu Hanaoka is the most well known even in foreign countries as well as in Japan. His detailed biography is described in a monograph by Shuzo Kure published in 1923 which has been the most important book for the study of Seishu Hanaoka. Hanaoka had worked very hard in various fields as surgeons, educator, poet and community developer. However, his best noted activity was his devotion to the development of oral general anesthetic "Mafutsu-San" or "Tsusen-San". He was the first to succeed in the excision of breast cancer in a 60 year old woman named Kan Aiya under general anesthesia with this agent on Oct 13th, 1804. The details of the case have been known to us, as the manuscript on the case which is believed to be by the hand of Hanaoka is extant in the Tenri Library, Tenri University and the whole manuscripts have been printed in Kure's monograph. For the past twenty years, I have studied carefully the microfilmed manuscript and the printed sentences appeared in Kure's book to find several serious bibliographical errors and dubious points between them. They are as follows. 1) There is no definite proof that the manuscript was transcribed by Seishu Hanaoka himself. This was originally proposed by Shuzo Kure without any rational reasons. 2) There are seven fundamental and unbelievable errors of incorrect use of Chinese characters in the manuscript. These basic errors can not be committed by Hanaoka considering that he was an excellent poet. For these errors Shuzo Kure falsified them to be printed in his book. He even altered Chinese characters in one of the photographs of the manuscript in his book. 3) Shuzo Kure did not exhibit this manuscript at the exhibition on the occasion of 150 anniversary of Seishu Hanaoka's death in Tokyo, supposedly to avoid careful study by other investigators. All above mentioned findings strongly suggest us that the manuscript "Nyugan Chiken Roku" could be transcribed by one of Hanaoka's disciples and not by Hanaoka himself.

Analysis of Production, Impact, and Scientific Collaboration on Difficult Airway Through the Web of Science and Scopus (1981-2013).

PubMed

García-Aroca, Miguel Ángel; Pandiella-Dominique, Andrés; Navarro-Suay, Ricardo; Alonso-Arroyo, Adolfo; Granda-Orive, José Ignacio; Anguita-Rodríguez, Francisco; López-García, Andrés

2017-06-01

Bibliometrics, the statistical analysis of written publications, is an increasingly popular approach to the assessment of scientific activity. Bibliometrics allows researchers to assess the impact of a field, or research area, and has been used to make decisions regarding research funding. Through bibliometric analysis, we hypothesized that a bibliometric analysis of difficult airway research would demonstrate a growth in authors and articles over time. Using the Web of Science (WoS) and Scopus databases, we conducted a search of published manuscripts on the difficult airway from January 1981 to December 2013. After removal of duplicates, we identified 2412 articles. We then analyzed the articles as a group to assess indicators of productivity, collaboration, and impact over this time period. We found an increase in productivity over the study period, with 37 manuscripts published between 1981 and 1990, and 1268 between 2001 and 2010 (P < .001). The difficult airway papers growth rate was bigger than that of anesthesiology research in general, with CAGR (cumulative average growth rate) since 1999 for difficult airway >9% for both WoS and Scopus, and CAGR for anesthesiology as a whole =0.64% in WoS, and =3.30% in Scopus. Furthermore, we found a positive correlation between the number of papers published per author and the number of coauthored manuscripts (P < .001). We also found an increase in the number of coauthored manuscripts, in international cooperation between institutions, and in the number of citations for each manuscript. For any author, we also identified a positive relationship between the number of citations per manuscript and the number of papers published (P < .001). We found a greater increase over time in the number of difficult airway manuscripts than for anesthesiology research overall. We found that collaboration between authors increases their impact, and that an increase in collaboration increases citation rates. Publishing in English and in certain journals, and collaborating with certain authors and institutions, increases the visibility of manuscripts published on this subject.

Receptive Vocabulary Knowledge in Low Functioning Autism as Assessed by Eye Movements, Pupillary Dilation, and Event Related Potentials

DTIC Science & Technology

2014-06-01

that were expected (based on parental report) to be known by the individuals. The data for this group are currently included in a manuscript that...this group , as these individuals cannot provide very accurate information about what they know about words themselves. Relying on parental/caregiver...not expected to be known by the majority of the adult participants. Pretesting of these materials with a sep- arate group of normal adults from the

Vietnam Head Injury Study - Phase III: A 30-Year Post-Injury Follow-Up Study

DTIC Science & Technology

2007-08-01

Michael Koenigs1, Edward D. Huey1, Vanessa Raymont1,2, Bobby Cheon2, Jeffrey Solomon3, Eric M. Wassermann1, & Jordan Grafman1 1Cognitive Neuroscience...Currently, Dr. Vanessa Raymont and colleagues are about to submit a manuscript to the journal Brain entitled, “Demographic, Structural and Genetic...PENETRATING HEAD INJURY Vanessa Raymont1&2, Amanda Greathouse1&2, Katherine Reding1&2, Robert Lipsky3, Andres Salazar2, and Jordan Grafman2* 1

Animal Models of Human Granulocyte Diseases

PubMed Central

Schäffer, Alejandro A.; Klein, Christoph

2012-01-01

In vivo animal models have proven very useful to understand basic biological pathways of the immune system, a prerequisite for the development of innovate therapies. This manuscript addresses currently available models for defined human monogenetic defects of neutrophil granulocytes, including murine, zebrafish and larger mammalian species. Strengths and weaknesses of each system are summarized, and clinical investigators may thus be inspired to develop further lines of research to improve diagnosis and therapy by use of the appropriate animal model system. PMID:23351993

Thromboelastography as a Better Indicator of Postinjury Hypercoagulable State Than Prothrombin Time or Activated Partial Thromboplastin Time

DTIC Science & Technology

2009-08-01

trauma 53 Yes 9 Acute desaturation and lung consolidation Abbreviation: DVT, deep venous thrombosis. a All patients were men. All had pulmonary embolism. J Trauma. Author manuscript; available in PMC 2012 August 09. ...pulmonary embolism indicated that our current prophylaxis regimen could be improved. Keywords deep vein thrombosis; pulmonary embolism...important to accurately evaluate an injured patient’s hemostatic status to assess the need for and efficacy of deep vein thrombosis (DVT) prophylaxis

NCDC mass storage systems and technologies

NASA Technical Reports Server (NTRS)

Davis, Dick

1993-01-01

National Climatic Data Center (NCDC) data management issues are discussed, such as nature of holdings, history of the site, popularity of data sets, media/technology used for storage, volume distributed per month, mode of distribution, most frequently encountered problems, type of media requested/used, and evolution of media. Current holdings at NCDC are 107.8 terabytes of digital data and about 0.3 terabytes of manuscript data. The nexrad radar system is expected to generate approximately 88 terabytes per year by 1996.

Are we training pit bulls to review our manuscripts?

PubMed

Walbot, Virginia

2009-01-01

Good early training of graduate students and postdocs is needed to prevent them turning into future generations of manuscript-savaging reviewers. How can we intercalate typical papers into our training?

Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies

PubMed Central

Doctor, Allan; Zimmerman, Jerry; Agus, Michael; Rajasekaran, Surender; Wardenburg, Juliane Bubeck; Fortenberry, James; Zajicek, Anne; Typpo, Katri

2016-01-01

Objective To describe the state of the science, identify knowledge gaps, and offer potential future research questions regarding promising therapies for children with multiple organ dysfunction syndrome (MODS) presented during the Eunice Kennedy Shriver National Institute of Child Health and Human Development Workshop on Pediatric Multiple Organ Dysfunction Syndrome (March 26-27, 2015). Data Sources Literature review, research data, and expert opinion. Study Selection Not applicable. Data Extraction Moderated by an expert from the field, issues relevant to the association of MODS with a variety of conditions were presented, discussed and debated with a focus on identifying knowledge gaps and research priorities. Data Synthesis Summary of presentations and discussion supported and supplemented by relevant literature. Conclusions Among critically ill children, MODS is relatively common and associated with significant morbidity and mortality. For outcomes to improve, effective therapies aimed at preventing and treating this condition must be discovered and rigorously evaluated. In this manuscript, a number of potential opportunities to enhance current care are highlighted including the need for a better understanding of the pharmacokinetics and pharmacodynamics of medications, the effect of early and optimized nutrition, and the impact of effective glucose control in the setting of MODS. Additionally, a handful of the promising therapies either currently being implemented or developed are described. These include extracorporeal therapies, anti-cytokine therapies, anti-toxin treatments, anti-oxidant approaches and multiple forms of exogenous steroids. For the field to advance, these and other therapies must be assessed in rigorous manner and implemented accordingly. PMID:28248836

Superposed Epoch Analysis of Ring Current Geoeffectiveness Related to Solar Wind and Plasma Sheet Drivers

NASA Technical Reports Server (NTRS)

Liemohm, M. W.; Kozyra, J. U.; Thomsen, M. F.; Borovsky, J. E.; Gahurthakurta, Madulika (Technical Monitor)

2004-01-01

The goal of that proposal was to examine the relationship between solar wind drivers and ring current dynamics through data analysis and numerical simulations. The data analysis study was a statistical examination (via superposed epoch analyses) of a solar cycle's worth of storm data. Solar wind data, geophysical indices, and geosynchronous plasma data were collected for every time period with Dst< -50 nT from 1989 through 2002, and the storm list now exceeds 400 entries. This work was first conducted by a summer undergraduate student, Mr. John Vann (University of Kansas), with funding from the NSF Research Experience for Undergraduates program. It was then continued by a University of Michigan graduate student, Mr. Jichun Zhang. Mr. Zhang is now in his fourth year at U-M and is progressing very well toward a PhD in space science. His dissertation will be based on his data analysis and modeling efforts using this geomagnetic storm database. The results of the data analysis study have been the focus of several conference presentations, and the first manuscript has just been published. Two additional papers are presently being prepared, one on average (superposed) solar wind features for various storm subsets (e.g., intense storms at solar maximum), and another on geosynchronous plasma features for these same storm subsets. The latter result was highlighted by the TR&T program director in his presentation at the COSPAR meeting this summer.

Writing for publication in medical education: the benefits of a faculty development workshop and peer writing group.

PubMed

Steinert, Yvonne; McLeod, Peter J; Liben, Stephen; Snell, Linda

2008-01-01

Although educational innovations in medical education are increasing in number, many educators do not submit their ideas for publication. The goal of this initiative was to assist faculty members write about their educational innovations. Twenty-four faculty members participated in this intervention, which consisted of a half-day workshop, three peer writing groups, and independent study. We assessed the impact of this intervention through post-workshop evaluations, a one-year follow-up questionnaire, tracking of manuscript submissions, and an analysis of curriculum vitae. The workshop evaluations and one-year follow-up demonstrated that participants valued the workshop small groups, self-instructional workbook, and peer support and feedback provided by the peer writing groups. One year later, nine participants submitted a total of 14 manuscripts, 11 of which were accepted for publication. In addition, 10 participants presented a total of 38 abstracts at educational meetings. Five years later, we reviewed the curriculum vitae of all participants who had published or presented their educational innovation. Although the total number of publications remained the same, the number of educationally-related publications and presentations at scientific meetings increased considerably. A faculty development workshop and peer writing group can facilitate writing productivity and presentations of scholarly work in medical education.

[Medical manuscripts in the library of the Deontology Department of the Ankara University Medical School].

PubMed

Arda, B

1998-01-01

At every academical platform on medical history and its instruction, lack of Turkish medical historiography is mainly emphasized. There are two main factors determining the situation: 1-There isn't any comprehensive Turkish medical history textbook. 2-There are difficulties in reaching the primary sources in this field. Everybody agrees with the importance of reaching medical manuscripts easily and reading and evaluating them in medical history. For this reason, it is important to know where we can find them. In this article, medical manuscripts which are available in the library of the Deontology Department of Ankara University Medical School are introduced. The manuscripts have been listed in alphabetical order of the authors' name. The bibliographic items, such as the size, writing style, and type of paper used, are mentioned.

Malaysian Journal of Medical Sciences’ Publishing Report (2014–2015)

PubMed Central

Zulkapli, Nour Azimah; Sobi, Suhana; Mohd Zubaidi, Nor Azlina; Abdullah, Jafri Malin

2016-01-01

The Malaysian Journal of Medical Sciences (MJMS) has conducted a simple analysis of its scholarly publication, based on the auto-generated data compiled from ScholarOne Manuscripts™, an innovative, web-based, submission and peer-review workflow solution for scholarly publishers. The performance of the MJMS from 2014–2015 is reported on in this editorial, with a focus on the pattern of manuscript submission, geographical contributors and the acceptance-rejection rate. The total number of manuscript submissions has increased from 264 in 2014, to 272 in 2015. Malaysians are the main contributors to the MJMS. The total number of manuscript rejections following the review process was 79 (29.9%) in 2014, increasing to 92 (33.8%) the following year, in accordance with the exacting quality control criteria applied by the journal’s editor to the submitted manuscripts. PMID:27660539

Common statistical and research design problems in manuscripts submitted to high-impact psychiatry journals: what editors and reviewers want authors to know.

PubMed

Harris, Alex H S; Reeder, Rachelle; Hyun, Jenny K

2009-10-01

Journal editors and statistical reviewers are often in the difficult position of catching serious problems in submitted manuscripts after the research is conducted and data have been analyzed. We sought to learn from editors and reviewers of major psychiatry journals what common statistical and design problems they most often find in submitted manuscripts and what they wished to communicate to authors regarding these issues. Our primary goal was to facilitate communication between journal editors/reviewers and researchers/authors and thereby improve the scientific and statistical quality of research and submitted manuscripts. Editors and statistical reviewers of 54 high-impact psychiatry journals were surveyed to learn what statistical or design problems they encounter most often in submitted manuscripts. Respondents completed the survey online. The authors analyzed survey text responses using content analysis procedures to identify major themes related to commonly encountered statistical or research design problems. Editors and reviewers (n=15) who handle manuscripts from 39 different high-impact psychiatry journals responded to the survey. The most commonly cited problems regarded failure to map statistical models onto research questions, improper handling of missing data, not controlling for multiple comparisons, not understanding the difference between equivalence and difference trials, and poor controls in quasi-experimental designs. The scientific quality of psychiatry research and submitted reports could be greatly improved if researchers became sensitive to, or sought consultation on frequently encountered methodological and analytic issues.

Measuring the effectiveness of scientific gatekeeping.

PubMed

Siler, Kyle; Lee, Kirby; Bero, Lisa

2015-01-13

Peer review is the main institution responsible for the evaluation and gestation of scientific research. Although peer review is widely seen as vital to scientific evaluation, anecdotal evidence abounds of gatekeeping mistakes in leading journals, such as rejecting seminal contributions or accepting mediocre submissions. Systematic evidence regarding the effectiveness--or lack thereof--of scientific gatekeeping is scant, largely because access to rejected manuscripts from journals is rarely available. Using a dataset of 1,008 manuscripts submitted to three elite medical journals, we show differences in citation outcomes for articles that received different appraisals from editors and peer reviewers. Among rejected articles, desk-rejected manuscripts, deemed as unworthy of peer review by editors, received fewer citations than those sent for peer review. Among both rejected and accepted articles, manuscripts with lower scores from peer reviewers received relatively fewer citations when they were eventually published. However, hindsight reveals numerous questionable gatekeeping decisions. Of the 808 eventually published articles in our dataset, our three focal journals rejected many highly cited manuscripts, including the 14 most popular; roughly the top 2 percent. Of those 14 articles, 12 were desk-rejected. This finding raises concerns regarding whether peer review is ill--suited to recognize and gestate the most impactful ideas and research. Despite this finding, results show that in our case studies, on the whole, there was value added in peer review. Editors and peer reviewers generally--but not always-made good decisions regarding the identification and promotion of quality in scientific manuscripts.

Mentored peer review of standardized manuscripts as a teaching tool for residents: a pilot randomized controlled multi-center study.

PubMed

Wong, Victoria S S; Strowd, Roy E; Aragón-García, Rebeca; Moon, Yeseon Park; Ford, Blair; Haut, Sheryl R; Kass, Joseph S; London, Zachary N; Mays, MaryAnn; Milligan, Tracey A; Price, Raymond S; Reynolds, Patrick S; Selwa, Linda M; Spencer, David C; Elkind, Mitchell S V

2017-01-01

There is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality. A partially blinded, randomized, controlled multi-center study was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts. Sixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (-8.5%) and non-mentored (-13.9%) residents ( p  = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p  = 0.001), understanding of manuscripts (3.73 vs 2.87; p  = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p  = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p  = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p  = 0.50). We used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice.

Current concepts of ocular adnexal surgery

PubMed Central

Borrelli, Maria; Geerling, Gerd

2013-01-01

Ophthalmic Plastic and Reconstructive Surgery is a specialized area of ophthalmology that deals with the management of deformities and abnormalities of the eyelids, lacrimal system and the orbit. An ophthalmoplastic surgeon is able to identify and correct abnormalities of the ocular adnexae such as ectropion, lid retraction, conjunctival scarring with severe entropion, that can cause secondary ocular surface disorders; manage patients with watering eye, and when needed intervene with a dacryocystorhinostomy by external or endonasal approach and moreover minimize disfigurement following enucleation or evisceration and prevent further corneal damage, alleviate complains of tearing and grittiness, but also cosmetic complaints in patients with Graves’ orbitopathy. Aim of this manuscript was to review current established and recently evolving surgical procedures. PMID:26504698