Effect of Human Model Height and Sex on Induced Current Dosimetry in Household Induction Heater Users

NASA Astrophysics Data System (ADS)

Tarao, Hiroo; Hayashi, Noriyuki; Isaka, Katsuo

Induced currents in the high-resolution, anatomical human models are numerically calculated by the impedance method. The human models are supposed to be exposed to highly inhomogeneous 20.9 kHz magnetic fields from a household induction heater (IH). In the case of the adult models, the currents ranging from 5 to 19 mA/m2 are induced for between the shoulder and lower abdomen. Meanwhile, in the case of the child models, the currents ranging from 5 to 21 mA/m2 are induced for between the head and abdomen. In particular, the induced currents near the brain tissue are almost the same as those near the abdomen. When the induced currents in the central nervous system tissues are considered, the induced currents in the child model are 2.1 to 6.9 times as large as those in the adult model under the same B-field exposure environment. These results suggest the importance of further investigation intended for a pregnant female who uses the IH as well as for a child (or the IH users of small standing height).

Evaluating the Performance of the ff99SB Force Field Based on NMR Scalar Coupling Data

PubMed Central

Wickstrom, Lauren; Okur, Asim; Simmerling, Carlos

2009-01-01

Abstract Force-field validation is essential for the identification of weaknesses in current models and the development of more accurate models of biomolecules. NMR coupling and relaxation methods have been used to effectively diagnose the strengths and weaknesses of many existing force fields. Studies using the ff99SB force field have shown excellent agreement between experimental and calculated order parameters and residual dipolar calculations. However, recent studies have suggested that ff99SB demonstrates poor agreement with J-coupling constants for short polyalanines. We performed extensive replica-exchange molecular-dynamics simulations on Ala3 and Ala5 in TIP3P and TIP4P-Ew solvent models. Our results suggest that the performance of ff99SB is among the best of currently available models. In addition, scalar coupling constants derived from simulations in the TIP4P-Ew model show a slight improvement over those obtained using the TIP3P model. Despite the overall excellent agreement, the data suggest areas for possible improvement. PMID:19651043

Simulation analysis of receptive-field size of retinal horizontal cells by ionic current model.

PubMed

Aoyama, Toshihiro; Kamiyama, Yoshimi; Usui, Shiro

2005-01-01

The size of the receptive field of retinal horizontal cells changes with the state of dark/light adaptation. We have used a mathematical model to determine how changes in the membrane conductance affect the receptive-field properties of horizontal cells. We first modeled the nonlinear membrane properties of horizontal cells based on ionic current mechanisms. The dissociated horizontal cell model reproduced the voltage-current (V-I) relationships for various extracellular glutamate concentrations measured in electrophysiological studies. Second, a network horizontal cell model was also described, and it reproduced the V-I relationship observed in vivo. The network model showed a bell-shaped relationship between the receptive-field size and constant glutamate concentration. The simulated results suggest that the calcium current is a candidate for the bell-shaped length constant relationship.

A coronal magnetic field model with horizontal volume and sheet currents

NASA Technical Reports Server (NTRS)

Zhao, Xuepu; Hoeksema, J. Todd

1994-01-01

When globally mapping the observed photospheric magnetic field into the corona, the interaction of the solar wind and magnetic field has been treated either by imposing source surface boundary conditions that tacitly require volume currents outside the source surface or by limiting the interaction to thin current sheets between oppositely directed field regions. Yet observations and numerical Magnetohydrodynamic (MHD) calculations suggest the presence of non-force-free volume currents throughout the corona as well as thin current sheets in the neighborhoods of the interfaces between closed and open field lines or between oppositely directed open field lines surrounding coronal helmet-streamer structures. This work presents a model including both horizontal volume currents and streamer sheet currents. The present model builds on the magnetostatic equilibria developed by Bogdan and Low and the current-sheet modeling technique developed by Schatten. The calculation uses synoptic charts of the line-of-sight component of the photospheric magnetic field measured at the Wilcox Solar Observatory. Comparison of an MHD model with the calculated model results for the case of a dipole field and comparison of eclipse observations with calculations for CR 1647 (near solar minimum) show that this horizontal current-current-sheet model reproduces polar plumes and axes of corona streamers better than the source-surface model and reproduces polar plumes and axes of corona streamers better than the source-surface model and reproduces coro nal helmet structures better than the current-sheet model.

River Inflows into Lakes: Basin Temperature Profiles Driven By Peeling Detrainment from Dense Underflows

NASA Astrophysics Data System (ADS)

Hogg, C. A. R.; Huppert, H. E.; Imberger, J.; Dalziel, S. B.

2014-12-01

Dense gravity currents from river inflows feed fluid into confined basins in lakes. Large inflows can influence temperature profiles in the basins. Existing parameterisations of the circulation and mixing of such inflows are often based on the entrainment of ambient fluid into the underflowing gravity currents. However, recent observations have suggested that uni-directional entrainment into a gravity current does not fully describe the transfer between such gravity currents and the ambient water. Laboratory experiments visualised peeling detrainment from the gravity current occurring when the ambient fluid was stratified. A theoretical model of the observed peeling detrainment was developed to predict the temperature profile in the basin. This new model gives a better approximation of the temperature profile observed in the experiments than the pre-existing entraining model. The model can now be developed such that it integrates into operational models of lake basins.

Criticality and turbulence in a resistive magnetohydrodynamic current sheet

NASA Astrophysics Data System (ADS)

Klimas, Alexander J.; Uritsky, Vadim M.

2017-02-01

Scaling properties of a two-dimensional (2d) plasma physical current-sheet simulation model involving a full set of magnetohydrodynamic (MHD) equations with current-dependent resistivity are investigated. The current sheet supports a spatial magnetic field reversal that is forced through loading of magnetic flux containing plasma at boundaries of the simulation domain. A balance is reached between loading and annihilation of the magnetic flux through reconnection at the current sheet; the transport of magnetic flux from boundaries to current sheet is realized in the form of spatiotemporal avalanches exhibiting power-law statistics of lifetimes and sizes. We identify this dynamics as self-organized criticality (SOC) by verifying an extended set of scaling laws related to both global and local properties of the current sheet (critical susceptibility, finite-size scaling of probability distributions, geometric exponents). The critical exponents obtained from this analysis suggest that the model operates in a slowly driven SOC state similar to the mean-field state of the directed stochastic sandpile model. We also investigate multiscale correlations in the velocity field and find them numerically indistinguishable from certain intermittent turbulence (IT) theories. The results provide clues on physical conditions for SOC behavior in a broad class of plasma systems with propagating instabilities, and suggest that SOC and IT may coexist in driven current sheets which occur ubiquitously in astrophysical and space plasmas.

Criticality and turbulence in a resistive magnetohydrodynamic current sheet.

PubMed

Klimas, Alexander J; Uritsky, Vadim M

2017-02-01

Scaling properties of a two-dimensional (2d) plasma physical current-sheet simulation model involving a full set of magnetohydrodynamic (MHD) equations with current-dependent resistivity are investigated. The current sheet supports a spatial magnetic field reversal that is forced through loading of magnetic flux containing plasma at boundaries of the simulation domain. A balance is reached between loading and annihilation of the magnetic flux through reconnection at the current sheet; the transport of magnetic flux from boundaries to current sheet is realized in the form of spatiotemporal avalanches exhibiting power-law statistics of lifetimes and sizes. We identify this dynamics as self-organized criticality (SOC) by verifying an extended set of scaling laws related to both global and local properties of the current sheet (critical susceptibility, finite-size scaling of probability distributions, geometric exponents). The critical exponents obtained from this analysis suggest that the model operates in a slowly driven SOC state similar to the mean-field state of the directed stochastic sandpile model. We also investigate multiscale correlations in the velocity field and find them numerically indistinguishable from certain intermittent turbulence (IT) theories. The results provide clues on physical conditions for SOC behavior in a broad class of plasma systems with propagating instabilities, and suggest that SOC and IT may coexist in driven current sheets which occur ubiquitously in astrophysical and space plasmas.

Glass Property Models and Constraints for Estimating the Glass to be Produced at Hanford by Implementing Current Advanced Glass Formulation Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vienna, John D.; Kim, Dong-Sang; Skorski, Daniel C.

2013-07-01

Recent glass formulation and melter testing data have suggested that significant increases in waste loading in HLW and LAW glasses are possible over current system planning estimates. The data (although limited in some cases) were evaluated to determine a set of constraints and models that could be used to estimate the maximum loading of specific waste compositions in glass. It is recommended that these models and constraints be used to estimate the likely HLW and LAW glass volumes that would result if the current glass formulation studies are successfully completed. It is recognized that some of the models are preliminarymore » in nature and will change in the coming years. Plus the models do not currently address the prediction uncertainties that would be needed before they could be used in plant operations. The models and constraints are only meant to give an indication of rough glass volumes and are not intended to be used in plant operation or waste form qualification activities. A current research program is in place to develop the data, models, and uncertainty descriptions for that purpose. A fundamental tenet underlying the research reported in this document is to try to be less conservative than previous studies when developing constraints for estimating the glass to be produced by implementing current advanced glass formulation efforts. The less conservative approach documented herein should allow for the estimate of glass masses that may be realized if the current efforts in advanced glass formulations are completed over the coming years and are as successful as early indications suggest they may be. Because of this approach there is an unquantifiable uncertainty in the ultimate glass volume projections due to model prediction uncertainties that has to be considered along with other system uncertainties such as waste compositions and amounts to be immobilized, split factors between LAW and HLW, etc.« less

Comparing the costs of three prostate cancer follow-up strategies: a cost minimisation analysis.

PubMed

Pearce, Alison M; Ryan, Fay; Drummond, Frances J; Thomas, Audrey Alforque; Timmons, Aileen; Sharp, Linda

2016-02-01

Prostate cancer follow-up is traditionally provided by clinicians in a hospital setting. Growing numbers of prostate cancer survivors mean that this model of care may not be economically sustainable, and a number of alternative approaches have been suggested. The aim of this study was to develop an economic model to compare the costs of three alternative strategies for prostate cancer follow-up in Ireland-the European Association of Urology (EAU) guidelines, the National Institute of Health Care Excellence (NICE) guidelines and current practice. A cost minimisation analysis was performed using a Markov model with three arms (EAU guidelines, NICE guidelines and current practice) comparing follow-up for men with prostate cancer treated with curative intent. The model took a health care payer's perspective over a 10-year time horizon. Current practice was the least cost efficient arm of the model, the NICE guidelines were most cost efficient (74 % of current practice costs) and the EAU guidelines intermediate (92 % of current practice costs). For the 2562 new cases of prostate cancer diagnosed in 2009, the Irish health care system could have saved €760,000 over a 10-year period if the NICE guidelines were adopted. This is the first study investigating costs of prostate cancer follow-up in the Irish setting. While economic models are designed as a simplification of complex real-world situations, these results suggest potential for significant savings within the Irish health care system associated with implementation of alternative models of prostate cancer follow-up care.

MRMAide: a mixed resolution modeling aide

NASA Astrophysics Data System (ADS)

Treshansky, Allyn; McGraw, Robert M.

2002-07-01

The Mixed Resolution Modeling Aide (MRMAide) technology is an effort to semi-automate the implementation of Mixed Resolution Modeling (MRM). MRMAide suggests ways of resolving differences in fidelity and resolution across diverse modeling paradigms. The goal of MRMAide is to provide a technology that will allow developers to incorporate model components into scenarios other than those for which they were designed. Currently, MRM is implemented by hand. This is a tedious, error-prone, and non-portable process. MRMAide, in contrast, will automatically suggest to a developer where and how to connect different components and/or simulations. MRMAide has three phases of operation: pre-processing, data abstraction, and validation. During pre-processing the components to be linked together are evaluated in order to identify appropriate mapping points. During data abstraction those mapping points are linked via data abstraction algorithms. During validation developers receive feedback regarding their newly created models relative to existing baselined models. The current work presents an overview of the various problems encountered during MRM and the various technologies utilized by MRMAide to overcome those problems.

On the dynamics of the Mouth of the Columbia River: Results from a three-dimensional fully coupled wave-current interaction model

NASA Astrophysics Data System (ADS)

Akan, Çiǧdem; Moghimi, Saeed; Özkan-Haller, H. Tuba; Osborne, John; Kurapov, Alexander

2017-07-01

Numerical simulations were performed using a 3-D ocean circulation model (ROMS) two-way coupled to a phase-averaged wave propagation model (SWAN), to expand our understanding of the dynamics of wave-current interactions at the Mouth of the Columbia River (MCR). First, model results are compared with water elevations, currents, temperature, salinity, and wave measurements obtained by the U.S. Army Corp of Engineers during the Mega-Transect Experiment in 2005. We then discuss the effects of the currents on the waves and vice versa. Results show that wave heights are intensified notably at the entrance of the mouth in the presence of the tidal currents, especially in ebb flows. We also find nonlocal modifications to the wave field because of wave focusing processes that redirect wave energy toward the inlet mouth from adjacent areas, resulting in the presence of a tidal signatures in areas where local currents are weak. The model also suggests significant wave amplification at the edge of the expanding plume in the later stages of ebb, some tens of kilometers offshore of the inlet mouth, with potential implications for navigation safety. The effect of waves on the location of the plume is also analyzed, and results suggest that the plume is shifted in the down-wave direction when wave effects are considered, and that this shift is more pronounced for larger waves, and consistent with the presence of alongshore advection terms in the salt advection equation, which are related to the Stokes velocities associated with waves.

Climate change risks, extinction debt, and conservation implications for a threatened freshwater fish: Carmine shiner (Notropis percobromus).

PubMed

Pandit, Shubha N; Maitland, Bryan M; Pandit, Laxmi K; Poesch, Mark S; Enders, Eva C

2017-11-15

Climate change is affecting many freshwater species, particularly fishes. Predictions of future climate change suggest large and deleterious effects on species with narrow dispersal abilities due to limited hydrological connectivity. In turn, this creates the potential for population isolation in thermally unsuitable habitats, leading to physiological stress, species declines or possible extirpation. The current extent of many freshwater fish species' spatio-temporal distribution patterns and their sensitivity to thermal impacts from climate change - critical information for conservation planning - are often unknown. Carmine shiner (Notropis percobromus) is an ecologically important species listed as threatened or imperilled nationally (Canada) and regionally (South Dakota, United States) due to its restricted range and sensitivity to water quality and temperature. This research aimed to determine the current distribution and spatio-temporal variability in projected suitable habitat for Carmine shiner using niche-based modeling approaches (MaxEnt, BIOCLIM, and DOMAIN models). Statistically downscaled, bias-corrected Global Circulation Models (GCMs) data was used to model the distribution of Carmine shiner in central North America for the period of 2041-2060 (2050s). Maximum mean July temperature and temperature variability were the main factors in determining Carmine shiner distribution. Patterns of projected habitat change by the 2050s suggest the spatial extent of the current distribution of Carmine shiner would shift north, with >50% of the current distribution changing with future projections based on two Representative Concentrations Pathways for CO 2 emissions. Whereas the southern extent of the distribution would become unsuitable for Carmine shiner, suitable habitats are predicted to become available further north, if accessible. Importantly, the majority of habitat gains for Carmine shiner would be in areas currently inaccessible due to dispersal limitations, suggesting current populations may face an extinction debt within the next half century. These results provide evidence that Carmine shiner may be highly vulnerable to a warming climate and suggest that management actions - such as assisted migration - may be needed to mitigate impacts from climate change and ensure the long-term persistence of the species. Copyright © 2017 Elsevier B.V. All rights reserved.

Assessing forest vulnerability and the potential distribution of pine beetles under current and future climate scenarios in the Interior West of the US

USGS Publications Warehouse

Evangelista, P.H.; Kumar, S.; Stohlgren, T.J.; Young, N.E.

2011-01-01

The aim of our study was to estimate forest vulnerability and potential distribution of three bark beetles (Curculionidae: Scolytinae) under current and projected climate conditions for 2020 and 2050. Our study focused on the mountain pine beetle (Dendroctonus ponderosae), western pine beetle (Dendroctonus brevicomis), and pine engraver (Ips pini). This study was conducted across eight states in the Interior West of the US covering approximately 2.2millionkm2 and encompassing about 95% of the Rocky Mountains in the contiguous US. Our analyses relied on aerial surveys of bark beetle outbreaks that occurred between 1991 and 2008. Occurrence points for each species were generated within polygons created from the aerial surveys. Current and projected climate scenarios were acquired from the WorldClim database and represented by 19 bioclimatic variables. We used Maxent modeling technique fit with occurrence points and current climate data to model potential beetle distributions and forest vulnerability. Three available climate models, each having two emission scenarios, were modeled independently and results averaged to produce two predictions for 2020 and two predictions for 2050 for each analysis. Environmental parameters defined by current climate models were then used to predict conditions under future climate scenarios, and changes in different species' ranges were calculated. Our results suggested that the potential distribution for bark beetles under current climate conditions is extensive, which coincides with infestation trends observed in the last decade. Our results predicted that suitable habitats for the mountain pine beetle and pine engraver beetle will stabilize or decrease under future climate conditions, while habitat for the western pine beetle will continue to increase over time. The greatest increase in habitat area was for the western pine beetle, where one climate model predicted a 27% increase by 2050. In contrast, the predicted habitat of the mountain pine beetle from another climate model suggested a decrease in habitat areas as great as 46% by 2050. Generally, 2020 and 2050 models that tested the three climate scenarios independently had similar trends, though one climate scenario for the western pine beetle produced contrasting results. Ranges for all three species of bark beetles shifted considerably geographically suggesting that some host species may become more vulnerable to beetle attack in the future, while others may have a reduced risk over time. ?? 2011 Elsevier B.V.

FlexPepDock lessons from CAPRI peptide-protein rounds and suggested new criteria for assessment of model quality and utility.

PubMed

Marcu, Orly; Dodson, Emma-Joy; Alam, Nawsad; Sperber, Michal; Kozakov, Dima; Lensink, Marc F; Schueler-Furman, Ora

2017-03-01

CAPRI rounds 28 and 29 included, for the first time, peptide-receptor targets of three different systems, reflecting increased appreciation of the importance of peptide-protein interactions. The CAPRI rounds allowed us to objectively assess the performance of Rosetta FlexPepDock, one of the first protocols to explicitly include peptide flexibility in docking, accounting for peptide conformational changes upon binding. We discuss here successes and challenges in modeling these targets: we obtain top-performing, high-resolution models of the peptide motif for cases with known binding sites but there is a need for better modeling of flanking regions, as well as better selection criteria, in particular for unknown binding sites. These rounds have also provided us the opportunity to reassess the success criteria, to better reflect the quality of a peptide-protein complex model. Using all models submitted to CAPRI, we analyze the correlation between current classification criteria and the ability to retrieve critical interface features, such as hydrogen bonds and hotspots. We find that loosening the backbone (and ligand) RMSD threshold, together with a restriction on the side chain RMSD measure, allows us to improve the selection of high-accuracy models. We also suggest a new measure to assess interface hydrogen bond recovery, which is not assessed by the current CAPRI criteria. Finally, we find that surprisingly much can be learned from rather inaccurate models about binding hotspots, suggesting that the current status of peptide-protein docking methods, as reflected by the submitted CAPRI models, can already have a significant impact on our understanding of protein interactions. Proteins 2017; 85:445-462. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Plasmaspheric Erosion via Plasmasphere Coupling to Ring Current Plasmas: EUV Observations and Modeling

NASA Technical Reports Server (NTRS)

Adrian, M. L.; Gallagher, D. L.; Khazanov, G. V.; Chsang, S. W.; Liemohn, M. W.; Perez, J. D.; Green, J. L.; Sandel, B. R.; Mitchell, D. G.; Mende, S. B.;

Model Scaling of Hydrokinetic Ocean Renewable Energy Systems

NASA Astrophysics Data System (ADS)

von Ellenrieder, Karl; Valentine, William

2013-11-01

Numerical simulations are performed to validate a non-dimensional dynamic scaling procedure that can be applied to subsurface and deeply moored systems, such as hydrokinetic ocean renewable energy devices. The prototype systems are moored in water 400 m deep and include: subsurface spherical buoys moored in a shear current and excited by waves; an ocean current turbine excited by waves; and a deeply submerged spherical buoy in a shear current excited by strong current fluctuations. The corresponding model systems, which are scaled based on relative water depths of 10 m and 40 m, are also studied. For each case examined, the response of the model system closely matches the scaled response of the corresponding full-sized prototype system. The results suggest that laboratory-scale testing of complete ocean current renewable energy systems moored in a current is possible. This work was supported by the U.S. Southeast National Marine Renewable Energy Center (SNMREC).

Theories of Giant Planet Formation

NASA Technical Reports Server (NTRS)

Lissauer, Jack J.; Young, Richard E. (Technical Monitor)

1998-01-01

An overview of current theories of planetary formation, with emphasis on giant planets, is presented. The most detailed models are based upon observations of our own Solar System and of young stars and their environments. While these models predict that rocky planets should form around most single stars, the frequency of formation of gas giant planets is more difficult to predict theoretically. Terrestrial planets are believed to grow via pairwise accretion until the spacing of planetary orbits becomes large enough that the configuration is stable for the age of the system. Giant planets begin their growth as do terrestrial planets, but they become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates. Most models for extrasolar giant planets suggest that they formed as did Jupiter and Saturn (in nearly circular orbits, far enough from the star that ice could), and subsequently migrated to their current positions, although some models suggest in situ formation.

Redefining success as significance through leadership in the new economy.

PubMed

De Jong, Steven A

2006-03-01

This review re-examines our current definition of success in the current economic system and challenges the surgeon to play a significant part in role modeling and mentoring surgical residents and other healthcare professionals. Leadership skills are presented and implementation strategies are suggested.

Mental Models: Understanding the Impact of Fantasy Violence on Children's Moral Reasoning.

ERIC Educational Resources Information Center

Krcmar, Marina; Curtis, Stephen

2003-01-01

Tests the efficacy of mental models in understanding the effect of exposure to fantasy violence on children's responses to and reasoning about moral dilemmas involving aggression. Offers a possible extension to mental models that is consistent with current theory in cognitive science. Suggests that the activation of mental models regarding…

Current suicidal ideation in treatment-seeking individuals in the United Kingdom with gambling problems.

PubMed

Ronzitti, Silvia; Soldini, Emiliano; Smith, Neil; Potenza, Marc N; Clerici, Massimo; Bowden-Jones, Henrietta

2017-11-01

Studies show higher lifetime prevalence of suicidality in individuals with pathological gambling. However, less is known about the relationship between pathological gambling and current suicidal ideation. We investigated socio-demographic, clinical and gambling-related variables associated with suicidality in treatment-seeking individuals. Bivariate analyses and logistic regression models were generated on data from 903 individuals to identify measures associated with aspects of suicidality. Forty-six percent of patients reported current suicidal ideation. People with current suicidal thoughts were more likely to report greater problem-gambling severity (p<0.001), depression (p<0.001) and anxiety (p<0.001) compared to those without suicidality. Logistic regression models suggested that past suicidal ideation (p<0.001) and higher anxiety (p<0.05) may be predictive factors of current suicidality. Our findings suggest that the severity of anxiety disorder, along with a lifetime history of suicidal ideation, may help to identify treatment-seeking individuals with pathological gambling with a higher risk of suicidality, highlighting the importance of assessing suicidal ideation in clinical settings. Copyright © 2017 Elsevier Ltd. All rights reserved.

Perspectives for computational modeling of cell replacement for neurological disorders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aimone, James B.; Weick, Jason P.

In mathematical modeling of anatomically-constrained neural networks we provide significant insights regarding the response of networks to neurological disorders or injury. Furthermore, a logical extension of these models is to incorporate treatment regimens to investigate network responses to intervention. The addition of nascent neurons from stem cell precursors into damaged or diseased tissue has been used as a successful therapeutic tool in recent decades. Interestingly, models have been developed to examine the incorporation of new neurons into intact adult structures, particularly the dentate granule neurons of the hippocampus. These studies suggest that the unique properties of maturing neurons, can impactmore » circuit behavior in unanticipated ways. In this perspective, we review the current status of models used to examine damaged CNS structures with particular focus on cortical damage due to stroke. Secondly, we suggest that computational modeling of cell replacement therapies can be made feasible by implementing approaches taken by current models of adult neurogenesis. The development of these models is critical for generating hypotheses regarding transplant therapies and improving outcomes by tailoring transplants to desired effects.« less

Perspectives for computational modeling of cell replacement for neurological disorders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aimone, James B.; Weick, Jason P.

Mathematical modeling of anatomically-constrained neural networks has provided significant insights regarding the response of networks to neurological disorders or injury. A logical extension of these models is to incorporate treatment regimens to investigate network responses to intervention. The addition of nascent neurons from stem cell precursors into damaged or diseased tissue has been used as a successful therapeutic tool in recent decades. Interestingly, models have been developed to examine the incorporation of new neurons into intact adult structures, particularly the dentate granule neurons of the hippocampus. These studies suggest that the unique properties of maturing neurons, can impact circuit behaviormore » in unanticipated ways. In this perspective, we review the current status of models used to examine damaged CNS structures with particular focus on cortical damage due to stroke. Secondly, we suggest that computational modeling of cell replacement therapies can be made feasible by implementing approaches taken by current models of adult neurogenesis. The development of these models is critical for generating hypotheses regarding transplant therapies and improving outcomes by tailoring transplants to desired effects.« less

The agroecological matrix as alternative to the land-sparing/agriculture intensification model.

PubMed

Perfecto, Ivette; Vandermeer, John

2010-03-30

Among the myriad complications involved in the current food crisis, the relationship between agriculture and the rest of nature is one of the most important yet remains only incompletely analyzed. Particularly in tropical areas, agriculture is frequently seen as the antithesis of the natural world, where the problem is framed as one of minimizing land devoted to agriculture so as to devote more to conservation of biodiversity and other ecosystem services. In particular, the "forest transition model" projects an overly optimistic vision of a future where increased agricultural intensification (to produce more per hectare) and/or increased rural-to-urban migration (to reduce the rural population that cuts forest for agriculture) suggests a near future of much tropical aforestation and higher agricultural production. Reviewing recent developments in ecological theory (showing the importance of migration between fragments and local extinction rates) coupled with empirical evidence, we argue that there is little to suggest that the forest transition model is useful for tropical areas, at least under current sociopolitical structures. A model that incorporates the agricultural matrix as an integral component of conservation programs is proposed. Furthermore, we suggest that this model will be most successful within a framework of small-scale agroecological production.

Exciting (the) Vacuum: Possible Manifestations of the Higgs particle at the LHC

ScienceCinema

David Kaplan

2017-12-09

The Higgs boson is the particle most anticipated at the LHC. However, there is currently no leading theory of electroweak symmetry breaking (and the 'Higgs mechanism'). The many possibilities suggest many ways the Higgs could appear in the detectors, some of which require non-standard search methods. I will review the current state of beyond the standard model physics and the implication for Higgs physics. I then discuss some non-standard Higgs decays and suggest (perhaps naive) new experimental strategies for detecting the Higgs in such cases. In some models, while part of the new physics at the weak scale would be visible, the Higgs would be nearly impossible to detect.

Two ways to model voltage current curves of adiabatic MgB2 wires

NASA Astrophysics Data System (ADS)

Stenvall, A.; Korpela, A.; Lehtonen, J.; Mikkonen, R.

2007-08-01

Usually overheating of the sample destroys attempts to measure voltage-current curves of conduction cooled high critical current MgB2 wires at low temperatures. Typically, when a quench occurs a wire burns out due to massive heat generation and negligible cooling. It has also been suggested that high n values measured with MgB2 wires and coils are not an intrinsic property of the material but arise due to heating during the voltage-current measurement. In addition, quite recently low n values for MgB2 wires have been reported. In order to find out the real properties of MgB2 an efficient computational model is required to simulate the voltage-current measurement. In this paper we go back to basics and consider two models to couple electromagnetic and thermal phenomena. In the first model the magnetization losses are computed according to the critical state model and the flux creep losses are considered separately. In the second model the superconductor resistivity is described by the widely used power law. Then the coupled current diffusion and heat conduction equations are solved with the finite element method. In order to compare the models, example runs are carried out with an adiabatic slab. Both models produce a similar significant temperature rise near the critical current which leads to fictitiously high n values.

Simulated wind-generated inertial oscillations compared to current measurements in the northern North Sea

NASA Astrophysics Data System (ADS)

Bruserud, Kjersti; Haver, Sverre; Myrhaug, Dag

2018-06-01

Measured current speed data show that episodes of wind-generated inertial oscillations dominate the current conditions in parts of the northern North Sea. In order to acquire current data of sufficient duration for robust estimation of joint metocean design conditions, such as wind, waves, and currents, a simple model for episodes of wind-generated inertial oscillations is adapted for the northern North Sea. The model is validated with and compared against measured current data at one location in the northern North Sea and found to reproduce the measured maximum current speed in each episode with considerable accuracy. The comparison is further improved when a small general background current is added to the simulated maximum current speeds. Extreme values of measured and simulated current speed are estimated and found to compare well. To assess the robustness of the model and the sensitivity of current conditions from location to location, the validated model is applied at three other locations in the northern North Sea. In general, the simulated maximum current speeds are smaller than the measured, suggesting that wind-generated inertial oscillations are not as prominent at these locations and that other current conditions may be governing. Further analysis of the simulated current speed and joint distribution of wind, waves, and currents for design of offshore structures will be presented in a separate paper.

Simulated wind-generated inertial oscillations compared to current measurements in the northern North Sea

NASA Astrophysics Data System (ADS)

Bruserud, Kjersti; Haver, Sverre; Myrhaug, Dag

2018-04-01

Measured current speed data show that episodes of wind-generated inertial oscillations dominate the current conditions in parts of the northern North Sea. In order to acquire current data of sufficient duration for robust estimation of joint metocean design conditions, such as wind, waves, and currents, a simple model for episodes of wind-generated inertial oscillations is adapted for the northern North Sea. The model is validated with and compared against measured current data at one location in the northern North Sea and found to reproduce the measured maximum current speed in each episode with considerable accuracy. The comparison is further improved when a small general background current is added to the simulated maximum current speeds. Extreme values of measured and simulated current speed are estimated and found to compare well. To assess the robustness of the model and the sensitivity of current conditions from location to location, the validated model is applied at three other locations in the northern North Sea. In general, the simulated maximum current speeds are smaller than the measured, suggesting that wind-generated inertial oscillations are not as prominent at these locations and that other current conditions may be governing. Further analysis of the simulated current speed and joint distribution of wind, waves, and currents for design of offshore structures will be presented in a separate paper.

Fractal model of polarization switching kinetics in ferroelectrics under nonequilibrium conditions of electron irradiation

NASA Astrophysics Data System (ADS)

Maslovskaya, A. G.; Barabash, T. K.

2018-03-01

The paper presents the results of the fractal and multifractal analysis of polarization switching current in ferroelectrics under electron irradiation, which allows statistical memory effects to be estimated at dynamics of domain structure. The mathematical model of formation of electron beam-induced polarization current in ferroelectrics was suggested taking into account the fractal nature of domain structure dynamics. In order to realize the model the computational scheme was constructed using the numerical solution approximation of fractional differential equation. Evidences of electron beam-induced polarization switching process in ferroelectrics were specified at a variation of control model parameters.

The influence of media role models on gay, lesbian, and bisexual identity.

PubMed

Gomillion, Sarah C; Giuliano, Traci A

2011-01-01

The current investigation examined the influence of the media on gay, lesbian, and bisexual (GLB) identity using both survey and in-depth interview approaches. In Study 1, 126 GLB survey respondents (11 unreported) in Texas indicated that the media influenced their self-realization, coming out, and current identities by providing role models and inspiration. In Study 2, 15 interviewees (6 women and 9 men) revealed that media role models serve as sources of pride, inspiration, and comfort. Our findings suggest that increasing the availability of GLB role models in the media may positively influence GLB identity.

Social Integration in a Community College Environment

ERIC Educational Resources Information Center

Mertes, Scott J.

2015-01-01

Among current retention models, Tinto's Interactionalist Model has reached near paradigmatic status. When his model has been applied to two-year college settings, the social integration results have been inconsistent. This has led Maxwell (2000) and Deil-Amen (2011) to suggest that a different construct of social integration exists in community…

A Noncentral "t" Regression Model for Meta-Analysis

ERIC Educational Resources Information Center

Camilli, Gregory; de la Torre, Jimmy; Chiu, Chia-Yi

2010-01-01

In this article, three multilevel models for meta-analysis are examined. Hedges and Olkin suggested that effect sizes follow a noncentral "t" distribution and proposed several approximate methods. Raudenbush and Bryk further refined this model; however, this procedure is based on a normal approximation. In the current research literature, this…

Josephson A/D Converter Development.

DTIC Science & Technology

1981-10-01

by Zappe and A Landman [20]. They conclude that the simple model of the Josephson effect is applicable up to frequencies at least as high (a) as 300...GHz. B. Time-Domain Experiments 4ooF so The early high - frequency experiments with Josephson devices I .O suggested their use as very fast logic switches...exactly as for the phenomenological model . The tunneling pacitive current paths dominate the circuit at high frequencies . current is the sum of two

Biophysically realistic minimal model of dopamine neuron

NASA Astrophysics Data System (ADS)

Oprisan, Sorinel

2008-03-01

We proposed and studied a new biophysically relevant computational model of dopaminergic neurons. Midbrain dopamine neurons are involved in motivation and the control of movement, and have been implicated in various pathologies such as Parkinson's disease, schizophrenia, and drug abuse. The model we developed is a single-compartment Hodgkin-Huxley (HH)-type parallel conductance membrane model. The model captures the essential mechanisms underlying the slow oscillatory potentials and plateau potential oscillations. The main currents involved are: 1) a voltage-dependent fast calcium current, 2) a small conductance potassium current that is modulated by the cytosolic concentration of calcium, and 3) a slow voltage-activated potassium current. We developed multidimensional bifurcation diagrams and extracted the effective domains of sustained oscillations. The model includes a calcium balance due to the fundamental importance of calcium influx as proved by simultaneous electrophysiological and calcium imaging procedure. Although there are significant evidences to suggest a partially electrogenic calcium pump, all previous models considered only elecrtogenic pumps. We investigated the effect of the electrogenic calcium pump on the bifurcation diagram of the model and compared our findings against the experimental results.

Computational Modeling Reveals Key Contributions of KCNQ and hERG Currents to the Malleability of Uterine Action Potentials Underpinning Labor

PubMed Central

Tong, Wing-Chiu; Tribe, Rachel M.; Smith, Roger; Taggart, Michael J.

2014-01-01

The electrical excitability of uterine smooth muscle cells is a key determinant of the contraction of the organ during labor and is manifested by spontaneous, periodic action potentials (APs). Near the end of term, APs vary in shape and size reflecting an ability to change the frequency, duration and amplitude of uterine contractions. A recent mathematical model quantified several ionic features of the electrical excitability in uterine smooth muscle cells. It replicated many of the experimentally recorded uterine AP configurations but its limitations were evident when trying to simulate the long-duration bursting APs characteristic of labor. A computational parameter search suggested that delayed rectifying K+ currents could be a key model component requiring improvement to produce the longer-lasting bursting APs. Of the delayed rectifying K+ currents family it is of interest that KCNQ and hERG channels have been reported to be gestationally regulated in the uterus. These currents exhibit features similar to the broadly defined uterine I K1 of the original mathematical model. We thus formulated new quantitative descriptions for several I KCNQ and I hERG. Incorporation of these currents into the uterine cell model enabled simulations of the long-lasting bursting APs. Moreover, we used this modified model to simulate the effects of different contributions of I KCNQ and I hERG on AP form. Our findings suggest that the alterations in expression of hERG and KCNQ channels can potentially provide a mechanism for fine tuning of AP forms that lends a malleability for changing between plateau-like and long-lasting bursting-type APs as uterine cells prepare for parturition. PMID:25474527

Does the Current Minimum Validate (or Invalidate) Cycle Prediction Methods?

NASA Technical Reports Server (NTRS)

Hathaway, David H.

2010-01-01

This deep, extended solar minimum and the slow start to Cycle 24 strongly suggest that Cycle 24 will be a small cycle. A wide array of solar cycle prediction techniques have been applied to predicting the amplitude of Cycle 24 with widely different results. Current conditions and new observations indicate that some highly regarded techniques now appear to have doubtful utility. Geomagnetic precursors have been reliable in the past and can be tested with 12 cycles of data. Of the three primary geomagnetic precursors only one (the minimum level of geomagnetic activity) suggests a small cycle. The Sun's polar field strength has also been used to successfully predict the last three cycles. The current weak polar fields are indicative of a small cycle. For the first time, dynamo models have been used to predict the size of a solar cycle but with opposite predictions depending on the model and the data assimilation. However, new measurements of the surface meridional flow indicate that the flow was substantially faster on the approach to Cycle 24 minimum than at Cycle 23 minimum. In both dynamo predictions a faster meridional flow should have given a shorter cycle 23 with stronger polar fields. This suggests that these dynamo models are not yet ready for solar cycle prediction.

Modeling learning in brain stem and cerebellar sites responsible for VOR plasticity

NASA Technical Reports Server (NTRS)

Quinn, K. J.; Didier, A. J.; Baker, J. F.; Peterson, B. W.

1998-01-01

A simple model of vestibuloocular reflex (VOR) function was used to analyze several hypotheses currently held concerning the characteristics of VOR plasticity. The network included a direct vestibular pathway and an indirect path via the cerebellum. An optimization analysis of this model suggests that regulation of brain stem sites is critical for the proper modification of VOR gain. A more physiologically plausible learning rule was also applied to this network. Analysis of these simulation results suggests that the preferred error correction signal controlling gain modification of the VOR is the direct output of the accessory optic system (AOS) to the vestibular nuclei vs. a signal relayed through the cerebellum via floccular Purkinje cells. The potential anatomical and physiological basis for this conclusion is discussed, in relation to our current understanding of the latency of the adapted VOR response.

Convection, buoyancy or endolymph expansion: what is the actual mechanism responsible for the caloric response of semicircular canals?

PubMed

Valli, Paulo; Buizza, Angelo; Botta, Laura; Zucca, Giampiero; Ghezzi, Luciano; Valli, Stefano

The mechanisms underlying caloric nystagmus are still matter of debate. The original theory proposed by Barany and more recently by Pau and Limberg suggested that convective endolymphatic currents were involved. In contrast Gentine et al. suggested that the main mechanism responsible for caloric nystagmus is buoyancy due to calorization of the endolymph, without the need of continuous convective currents. Finally, other authors (Scherer and Clarke, Arai et al.) proposed that thermal expansion or contraction of the endolymph were involved. In the present study experimental conditions have been considered able to discriminate between these different models. The experiments, were carried out on isolated labyrinth preparations of the frog. Only the predictions of the model based on buoyancy were fully consistent with the experimental results whereas those provided by the other models were not.

Measles elimination in Italy: projected impact of the National Elimination Plan.

PubMed Central

Manfredi, P.; Williams, J. R.; Ciofi Degli Atti, M. L.; Salmaso, S.

2005-01-01

A mathematical model was used to evaluate the impact of the Italian Measles National Elimination Plan (NEP), and possible sources of failure in achieving its targets. The model considered two different estimates of force of infection, and the possible effect on measles transmission of the current Italian demographic situation, characterized by a below-replacement fertility. Results suggest that reaching all NEP targets will allow measles elimination to be achieved. In addition, the model suggests that achieving elimination by reaching a 95 % first-dose coverage appears unlikely; and that conducting catch-up activities, reaching high vaccination coverage, could interrupt virus circulation, but could not prevent the infection re-emerging before 2020. Also, the introduction of the second dose of measles vaccine seems necessary for achieving and maintaining elimination. Furthermore, current Italian demography appears to be favourable for reaching elimination. PMID:15724715

Genetic and ecological insights into glacial refugia of walnut (Juglans regia L.)

PubMed Central

Aradhya, Mallikarjuna; Ibrahimov, Zakir; Toktoraliev, Biimyrza; Maghradze, David; Musayev, Mirza; Bobokashvili, Zviadi; Preece, John E.

2017-01-01

The distribution and survival of trees during the last glacial maximum (LGM) has been of interest to paleoecologists, biogeographers, and geneticists. Ecological niche models that associate species occurrence and abundance with climatic variables are widely used to gain ecological and evolutionary insights and to predict species distributions over space and time. The present study deals with the glacial history of walnut to address questions related to past distributions through genetic analysis and ecological modeling of the present, LGM and Last Interglacial (LIG) periods. A maximum entropy method was used to project the current walnut distribution model on to the LGM (21–18 kyr BP) and LIG (130–116 kyr BP) climatic conditions. Model tuning identified the walnut data set filtered at 10 km spatial resolution as the best for modeling the current distribution and to hindcast past (LGM and LIG) distributions of walnut. The current distribution model predicted southern Caucasus, parts of West and Central Asia extending into South Asia encompassing northern Afghanistan, Pakistan, northwestern Himalayan region, and southwestern Tibet, as the favorable climatic niche matching the modern distribution of walnut. The hindcast of distributions suggested the occurrence of walnut during LGM was somewhat limited to southern latitudes from southern Caucasus, Central and South Asian regions extending into southwestern Tibet, northeastern India, Himalayan region of Sikkim and Bhutan, and southeastern China. Both CCSM and MIROC projections overlapped, except that MIROC projected a significant presence of walnut in the Balkan Peninsula during the LGM. In contrast, genetic analysis of the current walnut distribution suggested a much narrower area in northern Pakistan and the surrounding areas of Afghanistan, northwestern India, and southern Tajikistan as a plausible hotspot of diversity where walnut may have survived glaciations. Overall, the findings suggest that walnut perhaps survived the last glaciations in several refugia across a wide geographic area between 30° and 45° North latitude. However, humans probably played a significant role in the recent history and modern distribution of walnut. PMID:29023476

Genetic and ecological insights into glacial refugia of walnut (Juglans regia L.).

PubMed

Aradhya, Mallikarjuna; Velasco, Dianne; Ibrahimov, Zakir; Toktoraliev, Biimyrza; Maghradze, David; Musayev, Mirza; Bobokashvili, Zviadi; Preece, John E

2017-01-01

The distribution and survival of trees during the last glacial maximum (LGM) has been of interest to paleoecologists, biogeographers, and geneticists. Ecological niche models that associate species occurrence and abundance with climatic variables are widely used to gain ecological and evolutionary insights and to predict species distributions over space and time. The present study deals with the glacial history of walnut to address questions related to past distributions through genetic analysis and ecological modeling of the present, LGM and Last Interglacial (LIG) periods. A maximum entropy method was used to project the current walnut distribution model on to the LGM (21-18 kyr BP) and LIG (130-116 kyr BP) climatic conditions. Model tuning identified the walnut data set filtered at 10 km spatial resolution as the best for modeling the current distribution and to hindcast past (LGM and LIG) distributions of walnut. The current distribution model predicted southern Caucasus, parts of West and Central Asia extending into South Asia encompassing northern Afghanistan, Pakistan, northwestern Himalayan region, and southwestern Tibet, as the favorable climatic niche matching the modern distribution of walnut. The hindcast of distributions suggested the occurrence of walnut during LGM was somewhat limited to southern latitudes from southern Caucasus, Central and South Asian regions extending into southwestern Tibet, northeastern India, Himalayan region of Sikkim and Bhutan, and southeastern China. Both CCSM and MIROC projections overlapped, except that MIROC projected a significant presence of walnut in the Balkan Peninsula during the LGM. In contrast, genetic analysis of the current walnut distribution suggested a much narrower area in northern Pakistan and the surrounding areas of Afghanistan, northwestern India, and southern Tajikistan as a plausible hotspot of diversity where walnut may have survived glaciations. Overall, the findings suggest that walnut perhaps survived the last glaciations in several refugia across a wide geographic area between 30° and 45° North latitude. However, humans probably played a significant role in the recent history and modern distribution of walnut.

Equatorial ionospheric currents derived from MAGSAT data

NASA Technical Reports Server (NTRS)

Roy, M. (Principal Investigator)

1983-01-01

The MAGSAT data on the three component's of the geomagnetic field are subjected to ring current correction and crustal anomaly elimination near the dip equator. The evidence of a strong west east electrojet current below the satellite height (approximately 350 km) is confirmed. Strong evidence of east-west component of the field suggests the existence of a vertical current originating at the jet level and extending upwards. A model calculation shows that such a current system can explain the satellite data as well as the ground data.

Guidance: Strategies to Achieve Timely Settlement and Implementation of RD/RA at Superfund Sites

EPA Pesticide Factsheets

Memorandum recommends strategies to encourage PRPs to enter into a settlement using the model RD/RA Consent Decree; discusses the current model UAO; and suggests practical alternatives to expedite Superfund settlements and the cleanup process.

DIFMOD2: A NEXT GENERATION DIFFUSE LAYER MODEL

EPA Science Inventory

Jenne (1998) suggested that the majority of uncertainty in our current ability to model the environmental partitioning behavior of ionic species on natural surfaces resulted from uncertainties in our understanding of surface acidity behavior. Traditional 2-pK Grahame-Gouy-Chapma...

Theory and observations of upward field-aligned currents at the magnetopause boundary layer.

PubMed

Wing, Simon; Johnson, Jay R

2015-11-16

The dependence of the upward field-aligned current density ( J ‖ ) at the dayside magnetopause boundary layer is well described by a simple analytic model based on a velocity shear generator. A previous observational survey confirmed that the scaling properties predicted by the analytical model are applicable between 11 and 17 MLT. We utilize the analytic model to predict field-aligned currents using solar wind and ionospheric parameters and compare with direct observations. The calculated and observed parallel currents are in excellent agreement, suggesting that the model may be useful to infer boundary layer structures. However, near noon, where velocity shear is small, the kinetic pressure gradients and thermal currents, which are not included in the model, could make a small but significant contribution to J ‖ . Excluding data from noon, our least squares fit returns log( J ‖,max_cal ) = (0.96 ± 0.04) log( J ‖_obs ) + (0.03 ± 0.01) where J ‖,max_cal = calculated J ‖,max and J ‖_obs = observed J ‖ .

Integrative Analysis of Desert Dust Size and Abundance Suggests Less Dust Climate Cooling

NASA Technical Reports Server (NTRS)

Kok, Jasper F.; Ridley, David A.; Zhou, Qing; Miller, Ron L.; Zhao, Chun; Heald, Colette L.; Ward, Daniel S.; Albani, Samuel; Haustein, Karsten

2017-01-01

Desert dust aerosols affect Earths global energy balance through interactions with radiation, clouds, and ecosystems. But the magnitudes of these effects are so uncertain that it remains unclear whether atmospheric dust has a net warming or cooling effect on global climate. Consequently, it is still uncertain whether large changes in atmospheric dust loading over the past century have slowed or accelerated anthropogenic climate change, and the climate impact of possible future alterations in dust loading is similarly disputed. Here we use an integrative analysis of dust aerosol sizes and abundance to constrain the climatic impact of dust through direct interactions with radiation. Using a combination of observational, experimental, and model data, we find that atmospheric dust is substantially coarser than represented in current climate models. Since coarse dust warms global climate, the dust direct radiative effect (DRE) is likely less cooling than the 0.4 W m superscript 2 estimated by models in a current ensemble. We constrain the dust DRE to -0.20 (-0.48 to +0.20) W m superscript 2, which suggests that the dust DRE produces only about half the cooling that current models estimate, and raises the possibility that dust DRE is actually net warming the planet.

Introducing embedded indigenous psychological support teams: a suggested addition to psychological first aid in an international context.

PubMed

Edwards-Stewart, Amanda; Ahmad, Zeba S; Thoburn, John W; Furman, Rich; Lambert, Ashly J; Shelly, Lauren; Gunn, Ginger

2012-01-01

The current article introduces Embedded Indigenous Psychological Support Teams (IPST) as a possible addition to current disaster relief efforts. This article highlights psychological first aid in an international context by drawing on mainstream disaster relief models such as The American Red Cross, Critical Incident Stress Management, and Flexible Psychological First Aid. IPST are explained as teams utilizing techniques from both CISM and FPFA with a focus on resiliency. It is currently theorized that in utilizing IPST existing disaster relief models may be more effective in mitigating negative physical or mental health consequences post-disaster.

Photospheric Current Spikes as Possible Predictors of Flares

NASA Technical Reports Server (NTRS)

Goodman, Michael L.; Kwan, Chiman; Ayhan, Bulent; Shang, Eric L.

2016-01-01

Flares involve generation of the largest current densities in the solar atmosphere. This suggests the hypothesis that prior to a large (M,X) flare there are related time dependent changes in the photospheric current distribution, and hence in the resistive heating rate in neutral line regions (NLRs). If this is true, these changes might be useful predictors of flares. Evidence supporting this hypothesis is presented. Results from a data driven, near photospheric, 3D magnetohydrodynamic type model suggest the model might be useful for predicting M and X flares several hours to several days in advance. The model takes as input the photospheric magnetic field observed by the Helioseismic & Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO) satellite. The model computes quantities in every active region (AR) pixel for 14 ARs, with spurious Doppler periods due to SDO orbital motion filtered out of the time series of the magnetic field for each pixel. Spikes in the NLR resistive heating rate Q, appearing as increases by orders of magnitude above background values in the time series of Q are found to occur, and appear to be correlated with the occurrence of M or X flares a few hours to a few days later. The subset of spikes analyzed at the pixel level are found to occur on HMI and granulation scales of 1 arcsec and 12 minutes. Spikes are found in NLRs with and without M or X flares, and outside as well as inside NLRs, but the largest spikes are localized in the NLRs of ARs with M or X flares, and associated with horizontal magnetic field strengths several hG, and vertical magnetic field strengths several orders of magnitude smaller, suggesting that the spikes are associated with current sheets.

The Mechanisms of Manual Therapy in the Treatment of Musculoskeletal Pain: A Comprehensive Model

PubMed Central

Bialosky, Joel E; Bishop, Mark D; Price, Don D; Robinson, Michael E; George, Steven Z

2009-01-01

Prior studies suggest manual therapy (MT) as effective in the treatment of musculoskeletal pain; however, the mechanisms through which MT exerts its effects are not established. In this paper we present a comprehensive model to direct future studies in MT. This model provides visualization of potential individual mechanisms of MT that the current literature suggests as pertinent and provides a framework for the consideration of the potential interaction between these individual mechanisms. Specifically, this model suggests that a mechanical force from MT initiates a cascade of neurophysiological responses from the peripheral and central nervous system which are then responsible for the clinical outcomes. This model provides clear direction so that future studies may provide appropriate methodology to account for multiple potential pertinent mechanisms. PMID:19027342

Medium-Term Prospects for the Mexican Economy: Some Modeling Results

DTIC Science & Technology

1990-07-01

Mexican prospects. A base case scenario illustrates that without a net inflow of foreign capital, the peso cannot be sustained at current real levels... peso and no decline in real income. The model can also produce a pessimistic scenario that suggests the worst that might happen to the Mexican economy...net inflow of foreign capital (in the form of either lending or direct investment) the peso cannot be sustained at current real levels (assuming that

Integrated modeling of plasma ramp-up in DIII-D ITER-like and high bootstrap current scenario discharges

NASA Astrophysics Data System (ADS)

Wu, M. Q.; Pan, C. K.; Chan, V. S.; Li, G. Q.; Garofalo, A. M.; Jian, X.; Liu, L.; Ren, Q. L.; Chen, J. L.; Gao, X.; Gong, X. Z.; Ding, S. Y.; Qian, J. P.; Cfetr Physics Team

2018-04-01

Time-dependent integrated modeling of DIII-D ITER-like and high bootstrap current plasma ramp-up discharges has been performed with the equilibrium code EFIT, and the transport codes TGYRO and ONETWO. Electron and ion temperature profiles are simulated by TGYRO with the TGLF (SAT0 or VX model) turbulent and NEO neoclassical transport models. The VX model is a new empirical extension of the TGLF turbulent model [Jian et al., Nucl. Fusion 58, 016011 (2018)], which captures the physics of multi-scale interaction between low-k and high-k turbulence from nonlinear gyro-kinetic simulation. This model is demonstrated to accurately model low Ip discharges from the EAST tokamak. Time evolution of the plasma current density profile is simulated by ONETWO with the experimental current ramp-up rate. The general trend of the predicted evolution of the current density profile is consistent with that obtained from the equilibrium reconstruction with Motional Stark effect constraints. The predicted evolution of βN , li , and βP also agrees well with the experiments. For the ITER-like cases, the predicted electron and ion temperature profiles using TGLF_Sat0 agree closely with the experimental measured profiles, and are demonstrably better than other proposed transport models. For the high bootstrap current case, the predicted electron and ion temperature profiles perform better in the VX model. It is found that the SAT0 model works well at high IP (>0.76 MA) while the VX model covers a wider range of plasma current ( IP > 0.6 MA). The results reported in this paper suggest that the developed integrated modeling could be a candidate for ITER and CFETR ramp-up engineering design modeling.

The Substitution Augmentation Modification Redefinition (SAMR) Model: A Critical Review and Suggestions for Its Use

ERIC Educational Resources Information Center

Hamilton, Erica R.; Rosenberg, Joshua M.; Akcaoglu, Mete

2016-01-01

The Substitution, Augmentation, Modification, and Redefinition (SAMR) model is a four-level, taxonomy-based approach for selecting, using, and evaluating technology in K-12 settings (Puentedura 2006). Despite its increasing popularity among practitioners, the SAMR model is not currently represented in the extant literature. To focus the ongoing…

The Role of Creativity in Models of Resilience: Theoretical Exploration and Practical Applications

ERIC Educational Resources Information Center

Metzl, Einat S.; Morrell, Malissa A.

2008-01-01

This exploration reviews current conceptualizations of resilience and creativity, suggesting important links between these two concepts, and offers a modified model for future research and applied clinical interventions. First, the authors examine four main models of resilience. Then, an overview of definitions and characteristics of creativity is…

Exploring the Construct of Social Integration in a Community College Environment

ERIC Educational Resources Information Center

Mertes, Scott J.

2013-01-01

Among current retention models, Tinto's Interactionalist Model has reached near paradigmatic status. When his model has been applied to two-year college settings, the social integration results have been inconsistent. This has led Maxwell (2000) and Deil-Amen (2011) to suggest that a different construct of social integration exists in…

Proportional Reasoning of Preservice Elementary Education Majors: An Epistemic Model of the Proportional Reasoning Construct.

ERIC Educational Resources Information Center

Fleener, M. Jayne

Current research and learning theory suggest that a hierarchy of proportional reasoning exists that can be tested. Using G. Vergnaud's four complexity variables (structure, content, numerical characteristics, and presentation) and T. E. Kieren's model of rational number knowledge building, an epistemic model of proportional reasoning was…

Can Steady Magnetospheric Convection Events Inject Plasma into the Ring Current?

NASA Astrophysics Data System (ADS)

Lemon, C.; Chen, M. W.; Guild, T. B.

2009-12-01

Steady Magnetospheric Convection (SMC) events are characterized by several-hour periods of enhanced convection that are devoid of substorm signatures. There has long been a debate about whether substorms are necessary to inject plasma into the ring current, or whether enhanced convection is sufficient. If ring current injections occur during SMC intervals, this would suggest that substorms are unnecessary. We use a combination of simulations and data observations to examine this topic. Our simulation model computes the energy-dependent plasma drift in a self-consistent electric and magnetic field, which allows us to accurately model the transport of plasma from the plasma sheet (where the plasma pressure is much larger than the magnetic pressure) into the inner magnetosphere (where plasma pressure is much less than the magnetic pressure). In regions where the two pressures are comparable (i.e. the inner plasma sheet), feedback between the plasma and magnetic field is critical for accurately modeling the physical evolution of the system. Our previous work has suggested that entropy losses in the plasma sheet (such as caused by substorms) may be necessary to inject a ring current. However, it is not yet clear whether other small-scale processes (e.g. bursty bulk flows) can provide sufficient entropy loss in the plasma sheet to allow for the penetration of plasma into the ring current. We combine our simulation results with data observations in order to better understand the physical processes required to inject a ring current.

Rectification of nanopores in aprotic solvents - transport properties of nanopores with surface dipoles

NASA Astrophysics Data System (ADS)

Plett, Timothy; Shi, Wenqing; Zeng, Yuhan; Mann, William; Vlassiouk, Ivan; Baker, Lane A.; Siwy, Zuzanna S.

2015-11-01

Nanopores have become a model system to understand transport properties at the nanoscale. We report experiments and modeling of ionic current in aprotic solvents with different dipole moments through conically shaped nanopores in a polycarbonate film and through glass nanopipettes. We focus on solutions of the salt LiClO4, which is of great importance in modeling lithium based batteries. Results presented suggest ion current rectification observed results from two effects: (i) adsorption of Li+ ions to the pore walls, and (ii) a finite dipole moment rendered by adsorbed solvent molecules. Properties of surfaces in various solvents were probed by means of scanning ion conductance microscopy, which confirmed existence of an effectively positive surface potential in aprotic solvents with high dipole moments.Nanopores have become a model system to understand transport properties at the nanoscale. We report experiments and modeling of ionic current in aprotic solvents with different dipole moments through conically shaped nanopores in a polycarbonate film and through glass nanopipettes. We focus on solutions of the salt LiClO4, which is of great importance in modeling lithium based batteries. Results presented suggest ion current rectification observed results from two effects: (i) adsorption of Li+ ions to the pore walls, and (ii) a finite dipole moment rendered by adsorbed solvent molecules. Properties of surfaces in various solvents were probed by means of scanning ion conductance microscopy, which confirmed existence of an effectively positive surface potential in aprotic solvents with high dipole moments. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06340j

Fractional Zinc Absorption for Men, Women, and Adolescents Is Overestimated in the Current Dietary Reference Intakes.

PubMed

Armah, Seth M

2016-06-01

The fractional zinc absorption values used in the current Dietary Reference Intakes (DRIs) for zinc were based on data from published studies. However, the inhibitory effect of phytate was underestimated because of the low phytate content of the diets in the studies used. The objective of this study was to estimate the fractional absorption of dietary zinc from the US diet by using 2 published algorithms. Nutrient intake data were obtained from the NHANES 2009-2010 and the corresponding Food Patterns Equivalents Database. Data were analyzed with the use of R software by taking into account the complex survey design. The International Zinc Nutrition Consultative Group (IZiNCG; Brown et al. Food Nutr Bull 2004;25:S99-203) and Miller et al. (Br J Nutr 2013;109:695-700) models were used to estimate zinc absorption. Geometric means (95% CIs) of zinc absorption for all subjects were 30.1% (29.9%, 30.2%) or 31.3% (30.9%, 31.6%) with the use of the IZiNCG model and Miller et al. model, respectively. For men, women, and adolescents, absorption values obtained in this study with the use of the 2 models were 27.2%, 31.4%, and 30.1%, respectively, for the IZiNCG model and 28.0%, 33.0%, and 31.6%, respectively, for the Miller et al. model, compared with the 41%, 48%, and 40%, respectively, used in the current DRIs. For preadolescents, estimated absorption values (31.1% and 32.8% for the IZiNCG model and Miller et al. model, respectively) compare well with the conservative estimate of 30% used in the DRIs. When the new estimates of zinc absorption were applied to the current DRI values for men and women, the results suggest that the Estimated Average Requirement (EAR) and RDA for these groups need to be increased by nearly one-half of the current values in order to meet their requirements for absorbed zinc. These data suggest that zinc absorption is overestimated for men, women, and adolescents in the current DRI. Upward adjustments of the DRI for these groups are recommended. © 2016 American Society for Nutrition.

Evaluation of wind induced currents modeling along the Southern Caspian Sea

NASA Astrophysics Data System (ADS)

Bohluly, Asghar; Esfahani, Fariba Sadat; Montazeri Namin, Masoud; Chegini, Fatemeh

2018-02-01

To improve our understanding of the Caspian Sea hydrodynamics, its circulation is simulated with special focus on wind-driven currents of its southern basin. The hydrodynamic models are forced with a newly developed fine resolution wind field to increase the accuracy of current modeling. A 2D shallow water equation model and a 3D baroclinic model are applied separately to examine the performance of each model for specific applications in the Caspian Sea. The model results are validated against recent field measurements including AWAC and temperature observations in the southern continental shelf region. Results show that the 2D model is able to well predict the depth-averaged current speed in storm conditions in narrow area of southern coasts. This finding suggests physical oceanographers apply 2D modeling as a more affordable method for extreme current speed analysis at the continental shelf region. On the other hand the 3D model demonstrates a better performance in reproducing monthly mean circulation and hence is preferable for surface circulation of Caspian Sea. Monthly sea surface circulation fields of the southern basin reveal a dipole cyclonic-anticyclonic pattern, a dominant eastward current along the southern coasts which intensifies from May to November and a dominant southward current along the eastern coasts in all months except February when the flow is northward. Monthly mean wind fields exhibit two main patterns including a north-south pattern occurring at warm months and collision of two wind fronts especially in the cold months. This collision occurs on a narrow region at the southern continental shelf regions. Due to wind field complexities, it leads to a major source of uncertainty in predicting the wind-driven currents. However, this source of uncertainty is significantly alleviated by applying a fine resolution wind field.

From points to forecasts: Predicting invasive species habitat suitability in the near term

USGS Publications Warehouse

Holcombe, Tracy R.; Stohlgren, Thomas J.; Jarnevich, Catherine S.

2010-01-01

We used near-term climate scenarios for the continental United States, to model 12 invasive plants species. We created three potential habitat suitability models for each species using maximum entropy modeling: (1) current; (2) 2020; and (3) 2035. Area under the curve values for the models ranged from 0.92 to 0.70, with 10 of the 12 being above 0.83 suggesting strong and predictable species-environment matching. Change in area between the current potential habitat and 2035 ranged from a potential habitat loss of about 217,000 km2, to a potential habitat gain of about 133,000 km2.

Institutional Staff Training and Management: A Review of the Literature and a Model for Geriatric, Long-Term-Care Facilities.

ERIC Educational Resources Information Center

Burgio, Louis D.; Burgio, Kathryn L.

1990-01-01

Asserts that, if long-term care is to progress from custodial model to therapeutic model of rehabilitation, role of nursing assistants must be redesigned. Reviews current methods of institutional staff training and management and proposes model for geriatric, long-term care facilities. Discusses organizational resistance and offers suggestions for…

Emotional Modulation of Interval Timing and Time Perception

PubMed Central

Lake, Jessica I.; LaBar, Kevin S.; Meck, Warren H.

2017-01-01

Like other senses, our perception of time is not veridical, but rather, is modulated by changes in environmental context. Anecdotal experiences suggest that emotions can be powerful modulators of time perception; nevertheless, the functional and neural mechanisms underlying emotion-induced temporal distortions remain unclear. Widely accepted pacemaker-accumulator models of time perception suggest that changes in arousal and attention have unique influences on temporal judgments and contribute to emotional distortions of time perception. However, such models conflict with current views of arousal and attention suggesting that current models of time perception do not adequately explain the variability in emotion-induced temporal distortions. Instead, findings provide support for a new perspective of emotion-induced temporal distortions that emphasizes both the unique and interactive influences of arousal and attention on time perception over time. Using this framework, we discuss plausible functional and neural mechanisms of emotion-induced temporal distortions and how these temporal distortions may have important implications for our understanding of how emotions modulate our perceptual experiences in service of adaptive responding to biologically relevant stimuli. PMID:26972824

Estimation of steady-state leakage current in polycrystalline PZT thin films

NASA Astrophysics Data System (ADS)

Podgorny, Yury; Vorotilov, Konstantin; Sigov, Alexander

2016-09-01

Estimation of the steady state (or "true") leakage current Js in polycrystalline ferroelectric PZT films with the use of the voltage-step technique is discussed. Curie-von Schweidler (CvS) and sum of exponents (Σ exp ) models are studied for current-time J (t) data fitting. Σ exp model (sum of three or two exponents) gives better fitting characteristics and provides good accuracy of Js estimation at reduced measurement time thus making possible to avoid film degradation, whereas CvS model is very sensitive to both start and finish time points and give in many cases incorrect results. The results give rise to suggest an existence of low-frequency relaxation processes in PZT films with characteristic duration of tens and hundreds of seconds.

I Want You to Hold My Hand--Right Now!

ERIC Educational Resources Information Center

Weldy Boyd, Amanda C.

2012-01-01

The author argues that the excessive desire for a teacher's or mentor's feedback is not exclusive to the current "iGeneration." She suggests that one of the responsibilities of educators is teaching students to be less hesitant to make their own judgments. She then calls upon current teachers and administrators to model reasonable…

Integrating Practice-to-Theory and Theory-to-Practice

ERIC Educational Resources Information Center

Johnson, R. Burke; Stefurak, Tres

2012-01-01

In "Towards a systemic theory of gifted education", Ziegler and Phillipson offer a useful critique of current research and the current paradigm in gifted education. They provide an interesting and useful merging of systems theory with their actiotope model, and using this paradigm they suggest many fruitful areas for future research. However, the…

Improving the representation of Arctic photosynthesis in Earth System Models

NASA Astrophysics Data System (ADS)

Rogers, A.; Serbin, S.; Sloan, V. L.; Norby, R. J.; Wullschleger, S. D.

2014-12-01

The primary goal of Earth System Models (ESMs) is to improve understanding and projection of future global change. In order to do this models must accurately represent the terrestrial carbon cycle. Although Arctic carbon fluxes are small relative to global carbon fluxes, uncertainty is large. Photosynthetic CO2 uptake is well described by the Farquhar, von Caemmerer and Berry (FvCB) model of photosynthesis and most ESMs use a derivation of the FvCB model to calculate gross primary productivity. Two key parameters required by the FvCB model are an estimate of the maximum rate of carboxylation by the enzyme Rubisco (Vc,max) and the maximum rate of electron transport (Jmax). In ESMs the parameter Vc,max is typically fixed for a given plant functional type (PFT). Only four ESMs currently have an explicit Arctic PFT and the data used to derive Vc,max in these models relies on small data sets and unjustified assumptions. We examined the derivation of Vc,max and Jmax in current Arctic PFTs and estimated Vc,max and Jmax for a range of Arctic PFTs growing on the Barrow Environmental Observatory, Barrow, AK. We found that the values of Vc,max currently used to represent Arctic plants in ESMs are 70% lower than the values we measured, and contemporary temperature response functions for Vc,max also appear to underestimate Vc,max at low temperature. ESMs typically use a single multiplier (JVratio) to convert Vc,max to Jmax, however we found that the JVratio of Arctic plants is higher than current estimates suggesting that Arctic PFTs will be more responsive to rising carbon dioxide than currently projected. In addition we are exploring remotely sensed methods to scale up key biochemical (e.g. leaf N, leaf mass area) and physiological (e.g. Vc,max and Jmax) properties that drive model representation of photosynthesis in the Arctic. Our data suggest that the Arctic tundra has a much greater capacity for CO2 uptake, particularly at low temperature, and will be more CO2 responsive than is currently represented in ESMs. As we build robust relationships between physiology and spectral signatures we hope to provide spatially and temporally resolved trait maps of key model parameters that can be ingested by new model frameworks, or used to validate emergent model properties.

Observed and Modeled HOCl Profiles in the Midlatitude Stratosphere: Implication for Ozone Loss

NASA Technical Reports Server (NTRS)

Kovalenko, L. J.; Jucks, K. W.; Salawitch, R. J.; Toon, G. C.; Blavier, J. F.; Johnson, D. G.; Kleinbohl, A.; Livesey, N. J .; Margitan, J. J.; Pickett, H. M.;

[The nature, diagnosis and treatment of post-concussion syndrome].

PubMed

Muñoz-Céspedes, J M; Pelegrín-Valero, C; Tirapu-Ustarroz, J; Fernández-Guinea, S

1998-11-01

The relationship between brief loss of consciousness, subsequent cognitive and emotional complaints, and impact on daily functioning continues to be hotly debated. In this paper the strong variability about prevalence of the postconcussional syndrome found in several studies is outstanding and the main issues of this disagreement are suggested. Recent neuroimaging techniques are discussed and some neuropsychological measures are suggested. Currents models (organic/psychogenic) of postconcussional symptoms are reviewed, and a multifactorial model which integrates biological factors with the relevance of neuropsychological deficits--attention, memory, speed of information processing--and coping process is proposed. Finally, according with this model, we conclude with some suggestions to improve neuropsychological intervention and medical treatment of these patients.

Test of electical resistivity and current diffusion modelling on MAST and JET

NASA Astrophysics Data System (ADS)

Keeling, D. L.; Challis, C. D.; Jenkins, I.; Hawkes, N. C.; Lupelli, I.; Michael, C.; de Bock, M. F. M.; the MAST Team; contributors, JET

2018-01-01

Experiments have been carried out on the MAST and JET tokamaks intended to compare the electrical resistivity of the plasma with theoretical formulations. The tests consist of obtaining motional stark effect (MSE) measurements in MHD-free plasmas during plasma current ramp-up (JET and MAST), ramp-down (MAST) and in stationary state (JET and MAST). Simulations of these plasmas are then performed in which the current profile evolution is calculated according to the poloidal field diffusion equation (PFDE) with classical or neoclassical resistivity. Synthetic MSE data are produced in the simulations for direct comparison with the experimental data. It is found that the toroidal current profile evolution modelled using neoclassical resistivity did not match the experimental observations on either device during current ramp-up or ramp-down as concluded from comparison of experimental and synthetic MSE profiles. In these phases, use of neoclassical resistivity in the modelling systematically overestimates the rate of current profile evolution. During the stationary state however, the modelled toroidal current profile matched experimental observations to a high degree of accuracy on both devices using neoclassical resistivity. Whilst no solution to the mismatch in the dynamic phases of the plasma is proposed, it is suggested that some physical process other than MHD which is not captured by the simple diffusive model of current profile evolution is responsible.

Dosage Considerations for Transcranial Direct Current Stimulation in Children: A Computational Modeling Study

PubMed Central

Kessler, Sudha Kilaru; Minhas, Preet; Woods, Adam J.; Rosen, Alyssa; Gorman, Casey; Bikson, Marom

2013-01-01

Transcranial direct current stimulation (tDCS) is being widely investigated in adults as a therapeutic modality for brain disorders involving abnormal cortical excitability or disordered network activity. Interest is also growing in studying tDCS in children. Limited empirical studies in children suggest that tDCS is well tolerated and may have a similar safety profile as in adults. However, in electrotherapy as in pharmacotherapy, dose selection in children requires special attention, and simple extrapolation from adult studies may be inadequate. Critical aspects of dose adjustment include 1) differences in neurophysiology and disease, and 2) variation in brain electric fields for a specified dose due to gross anatomical differences between children and adults. In this study, we used high-resolution MRI derived finite element modeling simulations of two healthy children, ages 8 years and 12 years, and three healthy adults with varying head size to compare differences in electric field intensity and distribution. Multiple conventional and high-definition tDCS montages were tested. Our results suggest that on average, children will be exposed to higher peak electrical fields for a given applied current intensity than adults, but there is likely to be overlap between adults with smaller head size and children. In addition, exposure is montage specific. Variations in peak electrical fields were seen between the two pediatric models, despite comparable head size, suggesting that the relationship between neuroanatomic factors and bioavailable current dose is not trivial. In conclusion, caution is advised in using higher tDCS doses in children until 1) further modeling studies in a larger group shed light on the range of exposure possible by applied dose and age and 2) further studies correlate bioavailable dose estimates from modeling studies with empirically tested physiologic effects, such as modulation of motor evoked potentials after stimulation. PMID:24086698

Developing guidance for budget impact analysis.

PubMed

Trueman, P; Drummond, M; Hutton, J

2001-01-01

The role of economic evaluation in the efficient allocation of healthcare resources has been widely debated. Whilst economic evidence is undoubtedly useful to purchasers, it does not address the issue of affordability which is an increasing concern. Healthcare purchasers are concerned not just with maximising efficiency but also with the more simplistic goal of remaining within their annual budgets. These two objectives are not necessarily consistent. This paper examines the issue of affordability, the relationship between affordability and efficiency and builds the case for why there is a growing need for budget impact models to complement economic evaluation. Guidance currently available for such models is also examined and it is concluded that this guidance is currently insufficient. Some of these insufficiencies are addressed and some thoughts on what constitutes best practice in budget impact modelling are suggested. These suggestions include consideration of transparency, clarity of perspective, reliability of data sources, the relationship between intermediate and final end-points and rates of adoption of new therapies. They also include the impact of intervention by population subgroups or indications, reporting of results, probability of re-deploying resources, the time horizon, exploring uncertainty and sensitivity analysis, and decision-maker access to the model. Due to the nature of budget impact models, the paper does not deliver stringent methodological guidance on modelling. The intention was to provide some suggestions of best practice in addition to some foundations upon which future research can build.

Trends in Mediation Analysis in Nursing Research: Improving Current Practice.

PubMed

Hertzog, Melody

2018-06-01

The purpose of this study was to describe common approaches used by nursing researchers to test mediation models and evaluate them within the context of current methodological advances. MEDLINE was used to locate studies testing a mediation model and published from 2004 to 2015 in nursing journals. Design (experimental/correlation, cross-sectional/longitudinal, model complexity) and analysis (method, inclusion of test of mediated effect, violations/discussion of assumptions, sample size/power) characteristics were coded for 456 studies. General trends were identified using descriptive statistics. Consistent with findings of reviews in other disciplines, evidence was found that nursing researchers may not be aware of the strong assumptions and serious limitations of their analyses. Suggestions for strengthening the rigor of such studies and an overview of current methods for testing more complex models, including longitudinal mediation processes, are presented.

Probing Lexical Representations: Simultaneous Modeling of Word and Reader Contributions to Multidimensional Lexical Representations

ERIC Educational Resources Information Center

Goodwin, Amanda P.; Gilbert, Jennifer K.; Cho, Sun-Joo; Kearns, Devin M.

2014-01-01

The current study models reader, item, and word contributions to the lexical representations of 39 morphologically complex words for 172 middle school students using a crossed random-effects item response model with multiple outcomes. We report 3 findings. First, results suggest that lexical representations can be characterized by separate but…

The Trouble with Applicant Impression Management.

ERIC Educational Resources Information Center

Ralston, Steven M.; Kirkwood, William G.

1999-01-01

Suggests that applicant impression management (AIM) is more harmful to employment interviewing than is currently suspected. Offers a conceptual model of AIM that is consistent with employment interviewing practice. Presents and critiques three arguments used to defend AIM. Examines a model for helping employers conduct interviews that minimize the…

Field investigation into unsaturated flow and transport in a fault: Model analyses

USGS Publications Warehouse

Liu, H.-H.; Salve, R.; Wang, J.-S.; Bodvarsson, G.S.; Hudson, D.

2004-01-01

Results of a fault test performed in the unsaturated zone of Yucca Mountain, Nevada, were analyzed using a three-dimensional numerical model. The fault was explicitly represented as a discrete feature and the surrounding rock was treated as a dual-continuum (fracture-matrix) system. Model calibration against seepage and water-travel-velocity data suggests that lithophysal cavities connected to fractures can considerably enhance the effective fracture porosity and therefore retard water flow in fractures. Comparisons between simulation results and tracer concentration data also indicate that matrix diffusion is an important mechanism for solute transport in unsaturated fractured rock. We found that an increased fault-matrix and fracture-matrix interface areas were needed to match the observed tracer data, which is consistent with previous studies. The study results suggest that the current site-scale model for the unsaturated zone of Yucca Mountain may underestimate radionuclide transport time within the unsaturated zone, because an increased fracture-matrix interface area and the increased effective fracture porosity arising from lithophysal cavities are not considered in the current site-scale model. ?? 2004 Published by Elsevier B.V.

Persistent superconductor currents in holographic lattices.

PubMed

Iizuka, Norihiro; Ishibashi, Akihiro; Maeda, Kengo

2014-07-04

We consider a persistent superconductor current along the direction with no translational symmetry in a holographic gravity model. Incorporating a lattice structure into the model, we numerically construct novel solutions of hairy charged stationary black branes with momentum or rotation along the latticed direction. The lattice structure prevents the horizon from rotating, and the total momentum is only carried by matter fields outside the black brane horizon. This is consistent with the black hole rigidity theorem, and it suggests that in dual field theory with lattices, superconductor currents are made up of "composite" fields, rather than "fractionalized" degrees of freedom. We also show that our solutions are consistent with the superfluid hydrodynamics.

Configuration and Generation of Substorm Current Wedge

NASA Astrophysics Data System (ADS)

Chu, Xiangning

The substorm current wedge (SCW), a core element of substorm dynamics coupling the magnetotail to the ionosphere, is crucial in understanding substorms. It has been suggested that the field-aligned currents (FACs) in the SCW are caused by either pressure gradients or flow vortices, or both. Our understanding of FAC generations is based predominately on numerical simulations, because it has not been possible to organize spacecraft observations in a coordinate system determined by the SCW. This dissertation develops an empirical inversion model of the current wedge and inverts midlatitude magnetometer data to obtain the parameters of the current wedge for three solar cycles. This database enables statistical data analysis of spacecraft plasma and magnetic field observations relative to the SCW coordinate. In chapter 2, a new midlatitude positive bay (MPB) index is developed and calculated for three solar cycles of data. The MPB index is processed to determine the substorm onset time, which is shown to correspond to the auroral breakup onset with at most 1-2 minutes difference. Substorm occurrence rate is found to depend on solar wind speed while substorm duration is rather constant, suggesting that substorm process has an intrinsic pattern independent of external driving. In chapter 3, an SCW inversion technique is developed to determine the strength and locations of the FACs in an SCW. The inversion parameters for FAC strength and location, and ring current strength are validated by comparison with other measurements. In chapter 4, the connection between earthward flows and auroral poleward expansion is examined using improved mapping, obtained from a newly-developed dynamic magnetospheric model by superimposing a standard magnetospheric field model with substorm current wedge obtained from the inversion technique. It is shown that the ionospheric projection of flows observed at a fixed point in the equatorial plane map to the bright aurora as it expands poleward, suggesting that auroral poleward expansion is mainly a consequence of magnetic dipolarization caused by the SCW. Chapter 5 shows that increased plasma pressure caused by flow braking has a temporal pattern similar to that of the currents in the SCW. In contrast, flow vortices vanish quickly, suggesting that pressure gradient is an important factor in generating the SCW. The measured pressure gradients are found to be organized relative to SCW central meridian. Nonalignment between pressure gradient and flux tube volume gradient lead to the generation of an SCW with quadrupole FACs (inner and outer loop of FACs). Because the inner current loop is weaker than the outer loop, the combined magnetic effect of the two current loops is similar to a classic SCW. The final chapter studies the magnetic flux transport by earthward flows, and accumulated inside the SCW and enclosed within auroral poleward boundary. Their good agreement suggests that flux accumulation causes magnetic dipolarization and auroral poleward expansion. The strength of the SCW is positively correlated with the amount of magnetic flux accumulated.

A Modelling Study of the Coastal Current in the Northwestern South China Sea: Response to Strong and Weak Southwest Monsoon

NASA Astrophysics Data System (ADS)

Ding, Y.; Yu, J.; Bao, X.; Yao, Z.

2016-02-01

The characteristics and dynamical mechanism of summer-time coastal current over the northwestern South China Sea (NSCS) shelf have been investigated based on a high resolution unstructured-grid finite volume community ocean model (FVCOM). Model-data comparison demonstrates that model well resolves the coastal dynamics over the NSCS shelf. The coastal current on the NSCS shelf is intensively influenced by monsoon and freshwater discharge of the Pearl River. Strong southwesterly wind drive the coastal current northeastward. However, under weak southwest monsoon, the coastal current west of Pearl River estuary (PRE) advects toward southwest, and splits into two parts when reaching east of the Qiongzhou Strait, with one branch entering the Gulf of Tonkin through the Qiongzhou Strait, transporting low salinity water into the Gulf of Tonkin, and the other part flows cyclonic and interacts with the northeastward current around southeast of Hainan Island, forming a cyclonic eddy east of the Qiongzhou Strait. A variety of model experiments focused on freshwater discharge, wind forcing, tidal rectification, and stratification are performed to study the physical mechanism of the southwestward coastal current which is usually against the summer wind. Process-oriented experiment results indicate that the southwest monsoon and freshwater discharge are important factors influencing the formation of southwestward coastal current during summer. Momentum balance analysis suggests that the along shelf barotropic pressure gradient due to the Pearl River discharge and wind forcing provides the main driving force for the southwestward coastal current.

Measurement and Modeling of Blocking Contacts for Cadmium Telluride Gamma Ray Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beck, Patrick R.

2010-01-07

Gamma ray detectors are important in national security applications, medicine, and astronomy. Semiconductor materials with high density and atomic number, such as Cadmium Telluride (CdTe), offer a small device footprint, but their performance is limited by noise at room temperature; however, improved device design can decrease detector noise by reducing leakage current. This thesis characterizes and models two unique Schottky devices: one with an argon ion sputter etch before Schottky contact deposition and one without. Analysis of current versus voltage characteristics shows that thermionic emission alone does not describe these devices. This analysis points to reverse bias generation current ormore » leakage through an inhomogeneous barrier. Modeling the devices in reverse bias with thermionic field emission and a leaky Schottky barrier yields good agreement with measurements. Also numerical modeling with a finite-element physics-based simulator suggests that reverse bias current is a combination of thermionic emission and generation. This thesis proposes further experiments to determine the correct model for reverse bias conduction. Understanding conduction mechanisms in these devices will help develop more reproducible contacts, reduce leakage current, and ultimately improve detector performance.« less

FHF2 isoforms differentially regulate Nav1.6 mediated resurgent sodium currents in dorsal root ganglion neurons

PubMed Central

Barbosa, Cindy; Xiao, Yucheng; Johnson, Andrew J.; Xie, Wenrui; Strong, Judith A.; Zhang, Jun-Ming; Cummins, Theodore R.

2017-01-01

Nav1.6 and Nav1.6 mediated resurgent currents have been implicated in several pain pathologies. However, our knowledge of how fast resurgent currents are modulated in neurons is limited. Our study explored the potential regulation of Nav1.6 mediated resurgent currents by isoforms of Fibroblast growth Factor Homologous factor 2 (FHF2) in an effort to address the gap in our knowledge. FHF2 isoforms colocalize with Nav1.6 in peripheral sensory neurons. Cell line studies suggest that these proteins differentially regulate inactivation. In particular, FHF2A mediates long-term inactivation, a mechanism proposed to compete with the open-channel blocker mechanism that mediates resurgent currents. On the other hand, FHF2B lacks the ability to mediate long-term inactivation and may delay inactivation favoring open-channel block. Based on these observations, we hypothesized that FHF2A limits resurgent currents, whereas, FHF2B enhances resurgent currents. Overall our results suggest that FHF2A negatively regulates fast resurgent current by enhancing long-term inactivation and delaying recovery. In contrast FHF2B positively regulated resurgent current and did not alter long-term inactivation. Chimeric constructs of FHF2A and Navβ4 (likely the endogenous open channel blocker in sensory neurons) exhibited differential effects on resurgent currents suggesting that specific regions within FHF2A and Navβ4 have important regulatory functions. Our data also indicate FHFAs and FHF2B isoform expression are differentially regulated in a radicular pain model and that associated neuronal hyperexcitability is substantially attenuated by a FHFA peptide. As such, these findings suggest that FHF2A and FHF2B regulate resurgent current in sensory neurons and may contribute to hyperexcitability associated with some pain pathologies. PMID:27999940

Seasonal cycle of circulation in the Antarctic Peninsula and the off-shelf transport of shelf waters into southern Drake Passage and Scotia Sea

NASA Astrophysics Data System (ADS)

Jiang, Mingshun; Charette, Matthew A.; Measures, Christopher I.; Zhu, Yiwu; Zhou, Meng

2013-06-01

The seasonal cycle of circulation and transport in the Antarctic Peninsula shelf region is investigated using a high-resolution (˜2 km) regional model based on the Regional Oceanic Modeling System (ROMS). The model also includes a naturally occurring tracer with a strong source over the shelf (radium isotope 228Ra, t1/2=5.8 years) to investigate the sediment Fe input and its transport. The model is spun-up for three years using climatological boundary and surface forcing and then run for the 2004-2006 period using realistic forcing. Model results suggest a persistent and coherent circulation system throughout the year consisting of several major components that converge water masses from various sources toward Elephant Island. These currents are largely in geostrophic balance, driven by surface winds, topographic steering, and large-scale forcing. Strong off-shelf transport of the Fe-rich shelf waters takes place over the northeastern shelf/slope of Elephant Island, driven by a combination of topographic steering, extension of shelf currents, and strong horizontal mixing between the ACC and shelf waters. These results are generally consistent with recent and historical observational studies. Both the shelf circulation and off-shelf transport show a significant seasonality, mainly due to the seasonal changes of surface winds and large-scale circulation. Modeled and observed distributions of 228Ra suggest that a majority of Fe-rich upper layer waters exported off-shelf around Elephant Island are carried by the shelfbreak current and the Bransfield Strait Current from the shallow sills between Gerlache Strait and Livingston Island, and northern shelf of the South Shetland Islands, where strong winter mixing supplies much of the sediment derived nutrients (including Fe) input to the surface layer.

Spectral characteristics of background error covariance and multiscale data assimilation

DOE PAGES

Li, Zhijin; Cheng, Xiaoping; Gustafson, Jr., William I.; ...

2016-05-17

The steady increase of the spatial resolutions of numerical atmospheric and oceanic circulation models has occurred over the past decades. Horizontal grid spacing down to the order of 1 km is now often used to resolve cloud systems in the atmosphere and sub-mesoscale circulation systems in the ocean. These fine resolution models encompass a wide range of temporal and spatial scales, across which dynamical and statistical properties vary. In particular, dynamic flow systems at small scales can be spatially localized and temporarily intermittent. Difficulties of current data assimilation algorithms for such fine resolution models are numerically and theoretically examined. Ourmore » analysis shows that the background error correlation length scale is larger than 75 km for streamfunctions and is larger than 25 km for water vapor mixing ratios, even for a 2-km resolution model. A theoretical analysis suggests that such correlation length scales prevent the currently used data assimilation schemes from constraining spatial scales smaller than 150 km for streamfunctions and 50 km for water vapor mixing ratios. Moreover, our results highlight the need to fundamentally modify currently used data assimilation algorithms for assimilating high-resolution observations into the aforementioned fine resolution models. Lastly, within the framework of four-dimensional variational data assimilation, a multiscale methodology based on scale decomposition is suggested and challenges are discussed.« less

Simulating potato gas exchange as influenced by CO2 and irrigation

USDA-ARS?s Scientific Manuscript database

Recent research suggests that an energy balance approach is required for crop models to adequately respond to current and future climatic conditions associated with elevated CO2, higher temperatures, and water scarcity. More realistic models are needed in order to understand the impact of, and deve...

Precision Optics Curriculum.

ERIC Educational Resources Information Center

Reid, Robert L.; And Others

This guide outlines the competency-based, two-year precision optics curriculum that the American Precision Optics Manufacturers Association has proposed to fill the void that it suggests will soon exist as many of the master opticians currently employed retire. The model, which closely resembles the old European apprenticeship model, calls for 300…

The morphology of flare phenomena, magnetic fields, and electric currents in active regions. III - NOAA active region 6233 (1990 August)

NASA Technical Reports Server (NTRS)

De La Beaujardiere, J.-F.; Canfield, Richard C.; Leka, K. D.

1993-01-01

We investigate the spatial relationship between vertical electric currents and flare phenomena in NOAA Active Region 6233, which was observed 1990, August 28-31 at Mees Solar Observatory. The two flares studied are the 1N/M1.8 flare on August 28, 22:30 UT and the 1N/M1.6 flare on August 29, 20:35 UT. Using Stokes polarimetry we make magnetograms of the region and compute the vertical current density. Using H-alpha imaging spectroscopy we identify sites of intense nonthermal electron precipitation or of high coronal pressure. The precipitation in these flares is barely strong enough to be detectable. We find that both precipitation and high pressure tend to occur near vertical currents, but that neither phenomenon is cospatial with current maxima. In contrast with the conclusion of other authors, we argue that these observations do not support a current-interruption model for flares, unless the relevant currents are primarily horizontal. The magnetic morphology and temporal evolution of these flares suggest that an erupting filament model may be relevant, but this model does not explicitly predict the relationship between precipitation, high pressure, and vertical currents.

Changing head model extent affects finite element predictions of transcranial direct current stimulation distributions

NASA Astrophysics Data System (ADS)

Indahlastari, Aprinda; Chauhan, Munish; Schwartz, Benjamin; Sadleir, Rosalind J.

2016-12-01

Objective. In this study, we determined efficient head model sizes relative to predicted current densities in transcranial direct current stimulation (tDCS). Approach. Efficiency measures were defined based on a finite element (FE) simulations performed using nine human head models derived from a single MRI data set, having extents varying from 60%-100% of the original axial range. Eleven tissue types, including anisotropic white matter, and three electrode montages (T7-T8, F3-right supraorbital, Cz-Oz) were used in the models. Main results. Reducing head volume extent from 100% to 60%, that is, varying the model’s axial range from between the apex and C3 vertebra to one encompassing only apex to the superior cerebellum, was found to decrease the total modeling time by up to half. Differences between current density predictions in each model were quantified by using a relative difference measure (RDM). Our simulation results showed that {RDM} was the least affected (a maximum of 10% error) for head volumes modeled from the apex to the base of the skull (60%-75% volume). Significance. This finding suggested that the bone could act as a bioelectricity boundary and thus performing FE simulations of tDCS on the human head with models extending beyond the inferior skull may not be necessary in most cases to obtain reasonable precision in current density results.

Implementing the correlated fermi gas nuclear model for quasielastic neutrino-nucleus scattering

NASA Astrophysics Data System (ADS)

Tockstein, Jameson

2017-09-01

When studying neutrino oscillations an understanding of charged current quasielastic (CCQE) neutrino-nucleus scattering is imperative. This interaction depends on a nuclear model as well as knowledge of form factors. Neutrino experiments, such as MiniBooNE, often use the Relativistic Fermi Gas (RFG) nuclear model. Recently, the Correlated Fermi Gas (CFG) nuclear model was suggested in, based on inclusive and exclusive scattering experiments at JLab. We implement the CFG model for CCQE scattering. In particular, we provide analytic expressions for this implementation that can be used to analyze current and future neutrino CCQE data. This project was supported through the Wayne State University REU program under NSF Grant PHY-1460853 and by the DOE Grant DE-SC0007983.

Extending the surrogacy analogy: applying the advance directive model to biobanks.

PubMed

Solomon, Stephanie; Mongoven, Ann

2015-01-01

Biobank donors and biobank governance face a conceptual challenge akin to clinical patients and their designated surrogate decision-makers, the necessity of making decisions and policies now that must be implemented under future unknown circumstances. We propose that biobanks take advantage of this parallel to learn lessons from the historical trajectory of advance directives and develop models analogous to current 'best practice' advance directives such as Values Histories and TheFive Wishes. We suggest how such models could improve biobanks' engagement both with communities and with individual donors by being more honest about the limits of current disclosure and eliciting information to ensure the protection of donor interests more robustly through time than current 'informed consent' processes in biobanking. © 2014 S. Karger AG, Basel.

Some Observations on the Current Status of Performing Finite Element Analyses

NASA Technical Reports Server (NTRS)

Raju, Ivatury S.; Knight, Norman F., Jr; Shivakumar, Kunigal N.

2015-01-01

Aerospace structures are complex high-performance structures. Advances in reliable and efficient computing and modeling tools are enabling analysts to consider complex configurations, build complex finite element models, and perform analysis rapidly. Many of the early career engineers of today are very proficient in the usage of modern computers, computing engines, complex software systems, and visualization tools. These young engineers are becoming increasingly efficient in building complex 3D models of complicated aerospace components. However, the current trends demonstrate blind acceptance of the results of the finite element analysis results. This paper is aimed at raising an awareness of this situation. Examples of the common encounters are presented. To overcome the current trends, some guidelines and suggestions for analysts, senior engineers, and educators are offered.

Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient.

PubMed

Datta, Abhishek; Baker, Julie M; Bikson, Marom; Fridriksson, Julius

2011-07-01

Although numerous published reports have demonstrated the beneficial effects of transcranial direct-current stimulation (tDCS) on task performance, fundamental questions remain regarding the optimal electrode configuration on the scalp. Moreover, it is expected that lesioned brain tissue will influence current flow and should therefore be considered (and perhaps leveraged) in the design of individualized tDCS therapies for stroke. The current report demonstrates how different electrode configurations influence the flow of electrical current through brain tissue in a patient who responded positively to a tDCS treatment targeting aphasia. The patient, a 60-year-old man, sustained a left hemisphere ischemic stroke (lesion size = 87.42 mL) 64 months before his participation. In this study, we present results from the first high-resolution (1 mm(3)) model of tDCS in a brain with considerable stroke-related damage; the model was individualized for the patient who received anodal tDCS to his left frontal cortex with the reference cathode electrode placed on his right shoulder. We modeled the resulting brain current flow and also considered three additional reference electrode positions: right mastoid, right orbitofrontal cortex, and a "mirror" configuration with the anode over the undamaged right cortex. Our results demonstrate the profound effect of lesioned tissue on resulting current flow and the ability to modulate current pattern through the brain, including perilesional regions, through electrode montage design. The complexity of brain current flow modulation by detailed normal and pathologic anatomy suggest: (1) That computational models are critical for the rational interpretation and design of individualized tDCS stroke-therapy; and (2) These models must accurately reproduce head anatomy as shown here. Copyright © 2011 Elsevier Inc. All rights reserved.

Career Path Suggestion using String Matching and Decision Trees

NASA Astrophysics Data System (ADS)

Nagpal, Akshay; P. Panda, Supriya

2015-05-01

High school and college graduates seemingly are often battling for the courses they should major in order to achieve their target career. In this paper, we worked on suggesting a career path to a graduate to reach his/her dream career given the current educational status. Firstly, we collected the career data of professionals and academicians from various career fields and compiled the data set by using the necessary information from the data. Further, this was used as the basis to suggest the most appropriate career path for the person given his/her current educational status. Decision trees and string matching algorithms were employed to suggest the appropriate career path for a person. Finally, an analysis of the result has been done directing to further improvements in the model.

A Probabilistic Model for Hydrokinetic Turbine Collision Risks: Exploring Impacts on Fish

PubMed Central

Hammar, Linus; Eggertsen, Linda; Andersson, Sandra; Ehnberg, Jimmy; Arvidsson, Rickard; Gullström, Martin; Molander, Sverker

2015-01-01

A variety of hydrokinetic turbines are currently under development for power generation in rivers, tidal straits and ocean currents. Because some of these turbines are large, with rapidly moving rotor blades, the risk of collision with aquatic animals has been brought to attention. The behavior and fate of animals that approach such large hydrokinetic turbines have not yet been monitored at any detail. In this paper, we conduct a synthesis of the current knowledge and understanding of hydrokinetic turbine collision risks. The outcome is a generic fault tree based probabilistic model suitable for estimating population-level ecological risks. New video-based data on fish behavior in strong currents are provided and models describing fish avoidance behaviors are presented. The findings indicate low risk for small-sized fish. However, at large turbines (≥5 m), bigger fish seem to have high probability of collision, mostly because rotor detection and avoidance is difficult in low visibility. Risks can therefore be substantial for vulnerable populations of large-sized fish, which thrive in strong currents. The suggested collision risk model can be applied to different turbine designs and at a variety of locations as basis for case-specific risk assessments. The structure of the model facilitates successive model validation, refinement and application to other organism groups such as marine mammals. PMID:25730314

A probabilistic model for hydrokinetic turbine collision risks: exploring impacts on fish.

PubMed

Hammar, Linus; Eggertsen, Linda; Andersson, Sandra; Ehnberg, Jimmy; Arvidsson, Rickard; Gullström, Martin; Molander, Sverker

2015-01-01

A variety of hydrokinetic turbines are currently under development for power generation in rivers, tidal straits and ocean currents. Because some of these turbines are large, with rapidly moving rotor blades, the risk of collision with aquatic animals has been brought to attention. The behavior and fate of animals that approach such large hydrokinetic turbines have not yet been monitored at any detail. In this paper, we conduct a synthesis of the current knowledge and understanding of hydrokinetic turbine collision risks. The outcome is a generic fault tree based probabilistic model suitable for estimating population-level ecological risks. New video-based data on fish behavior in strong currents are provided and models describing fish avoidance behaviors are presented. The findings indicate low risk for small-sized fish. However, at large turbines (≥5 m), bigger fish seem to have high probability of collision, mostly because rotor detection and avoidance is difficult in low visibility. Risks can therefore be substantial for vulnerable populations of large-sized fish, which thrive in strong currents. The suggested collision risk model can be applied to different turbine designs and at a variety of locations as basis for case-specific risk assessments. The structure of the model facilitates successive model validation, refinement and application to other organism groups such as marine mammals.

Diagnosis and Treatment of Reading Disabilities Based on the Component Model of Reading: An Alternative to the Discrepancy Model of LD

ERIC Educational Resources Information Center

Aaron, P. G.; Joshi, R. Malatesha; Gooden, Regina; Bentum, Kwesi E.

2008-01-01

Currently, learning disabilities (LD) are diagnosed on the basis of the discrepancy between students' IQ and reading achievement scores. Students diagnosed with LD often receive remedial instruction in resource rooms. The available evidence suggests that the educational policy based on this discrepancy model has not yielded satisfactory results.…

Diverse Multilingual Researchers Contribute Language Acquisition Components to an Integrated Model of Education

ERIC Educational Resources Information Center

Hobbs, Robert Dean

2012-01-01

Evidence-based outcomes in the literature have caused adjustments in neuro-psycholinguistic and sociolinguistic perspectives that indicate a need for a current model of education. Implications from research suggest the new model of education should use a multilingual framework: L3 enhances and reinforces L2 and L1, if L2 and L1 are supported. The…

Examining fluvial fish range loss with SDMs

USGS Publications Warehouse

Taylor, Andrew T.; Papeş, Monica; Long, James M.

2018-01-01

Fluvial fishes face increased imperilment from anthropogenic activities, but the specific factors contributing most to range declines are often poorly understood. For example, the range of the fluvial‐specialist shoal bass (Micropterus cataractae) continues to decrease, yet how perceived threats have contributed to range loss is largely unknown. We used species distribution models to determine which factors contributed most to shoal bass range loss. We estimated a potential distribution based on natural abiotic factors and a series of currently occupied distributions that incorporated variables characterizing land cover, non‐native species, and river fragmentation intensity (no fragmentation, dams only, and dams and large impoundments). We allowed interspecific relationships between non‐native congeners and shoal bass to vary across fragmentation intensities. Results from the potential distribution model estimated shoal bass presence throughout much of their native basin, whereas models of currently occupied distribution showed that range loss increased as fragmentation intensified. Response curves from models of currently occupied distribution indicated a potential interaction between fragmentation intensity and the relationship between shoal bass and non‐native congeners, wherein non‐natives may be favored at the highest fragmentation intensity. Response curves also suggested that >100 km of interconnected, free‐flowing stream fragments were necessary to support shoal bass presence. Model evaluation, including an independent validation, suggested that models had favorable predictive and discriminative abilities. Similar approaches that use readily available, diverse, geospatial data sets may deliver insights into the biology and conservation needs of other fluvial species facing similar threats.

Childhood emotional maltreatment as a robust predictor of suicidal ideation: A multi-wave, prospective investigation

PubMed Central

Miller, Adam Bryant; Jenness, Jessica L.; Oppenheimer, Caroline W.; Barrocas Gottleib, Andrea L.; Young, Jami F.; Hankin, Benjamin L.

2016-01-01

Despite literature suggesting a relationship between child maltreatment and suicidal ideation, few studies have examined the prospective course of this relationship. The current study examined this relationship in a sample of 682 community youth who were followed over the course of 3 years. Repeated measures of suicidal ideation, emotional maltreatment, and depressive symptom severity were examined in multi-wave path analysis models. Overall, results suggest that emotional maltreatment over time contributes uniquely to the prospective prediction of suicidal ideation, even when controlling for age, previous suicidal ideation, biological sex, and depression symptom severity. Unlike previous studies that have only measured emotional maltreatment at one-time point, the current study demonstrates that emotional maltreatment contributes unique risk to suicidal ideation prospectively among youth. Results speak to the importance of examining emotional maltreatment and suicidal ideation within prospective models of risk and suggest that emotional maltreatment is a robust predictor of suicidal ideation, over and above history of suicidal ideation and depression. PMID:27032784

Large dunes on the outer shelf off the Zambezi Delta, Mozambique: evidence for the existence of a Mozambique Current

NASA Astrophysics Data System (ADS)

Flemming, Burghard W.; Kudrass, Hermann-Rudolf

2018-02-01

The existence of a continuously flowing Mozambique Current, i.e. a western geostrophic boundary current flowing southwards along the shelf break of Mozambique, was until recently accepted by oceanographers studying ocean circulation in the south-western Indian Ocean. This concept was then cast into doubt based on long-term current measurements obtained from current-meter moorings deployed across the northern Mozambique Channel, which suggested that southward flow through the Mozambique Channel took place in the form of successive, southward migrating and counter-clockwise rotating eddies. Indeed, numerical modelling found that, if at all, strong currents on the outer shelf occurred for not more than 9 days per year. In the present study, the negation of the existence of a Mozambique Current is challenged by the discovery of a large (50 km long, 12 km wide) subaqueous dune field (with up to 10 m high dunes) on the outer shelf east of the modern Zambezi River delta at water depths between 50 and 100 m. Being interpreted as representing the current-modified, early Holocene Zambezi palaeo-delta, the dune field would have migrated southwards by at least 50 km from its former location since sea level recovered to its present-day position some 7 ka ago and after the former delta had been remoulded into a migrating dune field. Because a large dune field composed of actively migrating bedforms cannot be generated and maintained by currents restricted to a period of only 9 days per year, the validity of those earlier modelling results is questioned for the western margin of the flow field. Indeed, satellite images extracted from the Perpetual Ocean display of NASA, which show monthly time-integrated surface currents in the Mozambique Channel for the 5 month period from June-October 2006, support the proposition that strong flow on the outer Mozambican shelf occurs much more frequently than postulated by those modelling results. This is consistent with more recent modelling studies comparing the application of slippage and non-slippage approaches—they suggest that, when applying partial slippage, a western boundary current can exist simultaneously with the southward migrating eddies. Considering the evidence presented in this paper, it is concluded that a quasi-persistent, though seasonally variable Mozambique Current does exist.

Modeling the transition region

NASA Technical Reports Server (NTRS)

Singer, Bart A.

1993-01-01

The current status of transition-region models is reviewed in this report. To understand modeling problems, various flow features that influence the transition process are discussed first. Then an overview of the different approaches to transition-region modeling is given. This is followed by a detailed discussion of turbulence models and the specific modifications that are needed to predict flows undergoing laminar-turbulent transition. Methods for determining the usefulness of the models are presented, and an outlook for the future of transition-region modeling is suggested.

Physiological basis of a steady endogenous current in rat lumbrical muscle

PubMed Central

1984-01-01

In an attempt to determine the mechanism by which rat skeletal muscle endplates generate a steady outward current, we measured the effects of several drugs (furosemide, bumetanide, 9-anthracene carboxylic acid [9- AC]) and changes in external ion concentration (Na+, K+, Cl-, Ba++) on resting membrane potential (Vm) and on the steady outward current. Each of the following treatments caused a 10-15-mV hyperpolarization of the membrane: replacement of extracellular Cl- with isethionate, addition of furosemide or bumetanide, and addition of 9-AC. These results suggest that Cl- is actively accumulated by the muscle fibers and that the equilibrium potential of Cl- is more positive than the membrane potential. Removal of external Na+ also caused a large hyperpolarization and is consistent with evidence in other tissues that active Cl- accumulation requires external Na+. The same treatments greatly reduced or abolished the steady outward current, with a time course that paralleled the changes in Vm. These results cannot be explained by a model in which the steady outward current is assumed to arise as a result of a nonuniform distribution of Na+ conductance, but they are consistent with models in which the steady current is produced by a nonuniform distribution of GCl or GK. Other treatments (Na+-free and K+-free solutions, and 50 microM BaCl2) caused a temporary reversal of the steady current. Parallel measurements of Vm suggested that in none of these cases did the electrochemical driving force for K+ change sign, which makes it unlikely that the steady current arises as a result of a nonuniform distribution of GK. All of the results, however, are consistent with a model in which the steady outward current arises as a result of a nonuniform distribution of Cl- conductance, with GCl lower near the endplate than in extrajunctional regions. PMID:6325581

Maximum current density and beam brightness achievable by laser-driven electron sources

NASA Astrophysics Data System (ADS)

Filippetto, D.; Musumeci, P.; Zolotorev, M.; Stupakov, G.

2014-02-01

This paper discusses the extension to different electron beam aspect ratio of the Child-Langmuir law for the maximum achievable current density in electron guns. Using a simple model, we derive quantitative formulas in good agreement with simulation codes. The new scaling laws for the peak current density of temporally long and transversely narrow initial beam distributions can be used to estimate the maximum beam brightness and suggest new paths for injector optimization.

The Role of Academic Motivation in High School Students’ Current and Lifetime Alcohol Consumption: Adopting a Self-Determination Theory Perspective*

PubMed Central

Wormington, Stephanie V.; Anderson, Kristen G.; Corpus, Jennifer Henderlong

2011-01-01

Objective: The current study investigated the relationship between different types of academic motives—specifically, intrinsic motivation, introjected regulation, and external regulation—and high school students' current and lifetime alcohol consumption. Method: One thousand sixty-seven high school students completed measures of academic motivation, other school-related factors, and lifetime and current alcohol consumption. Results: Using structural equation modeling, different types of motivation and school-related factors were differentially related to student drinking. Specifically, intrinsic motivation was negatively related to lifetime and current alcohol consumption. External regulation, on the other hand, was positively associated with current drinking. Grade point average was the only school-related factor related to student alcohol use. Conclusions: These findings suggest that motivation is an important construct to consider in predicting students’ alcohol use, even when other more commonly studied educational variables are considered. In addition, it supports the adoption of a motivation framework that considers different types of motivation in understanding the relationship between academic motivation and alcohol use. Suggestions for incorporating the self-determination model of motivation into studies of alcohol and substance use, as well as potential impacts on intervention efforts, are discussed. In particular, it may be important to foster only certain types of motivation, rather than all types of academically-focused motives, in efforts to deter alcohol use. PMID:22051210

The role of academic motivation in high school students' current and lifetime alcohol consumption: adopting a self-determination theory perspective.

PubMed

Wormington, Stephanie V; Anderson, Kristen G; Corpus, Jennifer Henderlong

2011-11-01

The current study investigated the relationship between different types of academic motives-specifically, intrinsic motivation, introjected regulation, and external regulation-and high school students' current and lifetime alcohol consumption. One thousand sixty-seven high school students completed measures of academic motivation, other school-related factors, and lifetime and current alcohol consumption. Using structural equation modeling, different types of motivation and school-related factors were differentially related to student drinking. Specifically, intrinsic motivation was negatively related to lifetime and current alcohol consumption. External regulation, on the other hand, was positively associated with current drinking. Grade point average was the only school-related factor related to student alcohol use. These findings suggest that motivation is an important construct to consider in predicting students' alcohol use, even when other more commonly studied educational variables are considered. In addition, it supports the adoption of a motivation framework that considers different types of motivation in understanding the relationship between academic motivation and alcohol use. Suggestions for incorporating the self-determination model of motivation into studies of alcohol and substance use, as well as potential impacts on intervention efforts, are discussed. In particular, it may be important to foster only certain types of motivation, rather than all types of academically-focused motives, in efforts to deter alcohol use.

Extreme energetic particle decreases near geostationary orbit - A manifestation of current diversion within the inner plasma sheet

NASA Technical Reports Server (NTRS)

Baker, D. N.; Mcpherron, R. L.

1990-01-01

A qualitative model of cross-tail current flow is considered. It is suggested that when magnetic reconnection begins, the current effectively flows across the plasma sheet both earthward and tailward of the disruption region near the neutral line. It is shown that an enhanced cross-tail current earthward of this region would thin the plasma sheet substantially due to the magnetic pinch effect. The results explain the very taillike field and extreme particle dropouts often seen late in substorm growth phases.

Counter-current convection in a volcanic conduit

NASA Astrophysics Data System (ADS)

Fowler, A. C.; Robinson, Marguerite

2018-05-01

Volcanoes of Strombolian type are able to maintain their semi-permanent eruptive states through the constant convective recycling of magma within the conduit leading from the magma chamber. In this paper we study the form of this convection using an analytic model of degassing two-phase flow in a vertical channel. We provide solutions for the flow at small Grashof and large Prandtl numbers, and we suggest that permanent steady-state counter-current convection is only possible if an initial bubbly counter-current flow undergoes a régime transition to a churn-turbulent flow. We also suggest that the magma in the chamber must be under-pressured in order for the flow to be maintained, and that this compromises the assumed form of the flow.

Bounding species distribution models

USGS Publications Warehouse

Stohlgren, T.J.; Jarnevich, C.S.; Esaias, W.E.; Morisette, J.T.

2011-01-01

Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used. ?? 2011 Current Zoology.

Bounding Species Distribution Models

NASA Technical Reports Server (NTRS)

Stohlgren, Thomas J.; Jarnevich, Cahterine S.; Morisette, Jeffrey T.; Esaias, Wayne E.

2011-01-01

Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5): 642-647, 2011].

Culturally Responsive Pyramid Model Practices: Program-Wide Positive Behavior Support for Young Children

ERIC Educational Resources Information Center

Allen, Rosemarie; Steed, Elizabeth A.

2016-01-01

This conceptual article reviews current research on racial disparities in disciplinary practices in early childhood education and work to address these issues within a positive behavior support (PBS) framework. Building largely on the Pyramid Model, recommendations and a culturally responsive approach are suggested for use within a program-wide…

Automatic Generation of Customized, Model Based Information Systems for Operations Management.

DTIC Science & Technology

The paper discusses the need for developing a customized, model based system to support management decision making in the field of operations ... management . It provides a critique of the current approaches available, formulates a framework to classify logistics decisions, and suggests an approach for the automatic development of logistics systems. (Author)

Post-Employment Education and Training Models in the Welfare-to-Work Grant Program.

ERIC Educational Resources Information Center

Trutko, John; Nightingale, Deborah Smith; Barnow, Burt S.

This paper synthesizes what is currently known about providing education and training after an individual is employed and provides suggestions on models and strategies that can be effective in promoting occupational mobility and career advancement for welfare recipients. Among the rationales for considering education and training after an…

Classroom Tips.

ERIC Educational Resources Information Center

Crain, Cheryl

1994-01-01

Presents six teaching ideas from teachers in Foothills Schools, Alberta, Canada. Includes suggested activities on local government, computer uses in social studies, Canadian history, current events, and world studies. Provides models of a passport application, passports, and visas. (CFR)

Coulomb Blockade in a Two-Dimensional Conductive Polymer Monolayer.

PubMed

Akai-Kasaya, M; Okuaki, Y; Nagano, S; Mitani, T; Kuwahara, Y

2015-11-06

Electronic transport was investigated in poly(3-hexylthiophene-2,5-diyl) monolayers. At low temperatures, nonlinear behavior was observed in the current-voltage characteristics, and a nonzero threshold voltage appeared that increased with decreasing temperature. The current-voltage characteristics could be best fitted using a power law. These results suggest that the nonlinear conductivity can be explained using a Coulomb blockade (CB) mechanism. A model is proposed in which an isotropic extended charge state exists, as predicted by quantum calculations, and percolative charge transport occurs within an array of small conductive islands. Using quantitatively evaluated capacitance values for the islands, this model was found to be capable of explaining the observed experimental data. It is, therefore, suggested that percolative charge transport based on the CB effect is a significant factor giving rise to nonlinear conductivity in organic materials.

Combining Population Structure with Historic Abitoic Processes to Better Understand Species and Community Range Shifts in Response to Climate Change

NASA Astrophysics Data System (ADS)

Graham, N. M.

2015-12-01

The evolution and speciation of plants is directly tied to the environment as the constrained stages of dispersal creates strong genetic differentiation among populations. This can result in differing genetic patterns between nuclear and chloroplast loci, where genes are inherited differently and dispersed via separate vectors. By developing distribution models based on genetic patterns found within a species, it is possible to begin understanding the influence of historic geomorphic and/or climatic processes on population evolution. If genetic patterns of the current range correlate with specific patterns of climate variability within the Pleistocene, it is possible that future shifts in species distribution in response to climate change can be more accurately modelled due to the historic signature that is found within inherited genes. Preliminary genetic analyses of Linanthus dichotomus, an annual herb distributed across California, suggests that the current taxonomic treatment does not accurately depict how this species is evolving. Genetic patterns of chloroplast genes suggest that populations are more correlated with biogeography than what the current nomenclature states. Additionally, chloroplast and nuclear genes show discrepancies in the dispersal across the landscape, suggesting pollinator driven gene flow overcoming seed dispersal boundaries. By comparing discrepancies between pollinator and seed induced gene flow we may be able to gain insight into historical pollinator communities within the Pleistocene. This information can then be applied to projected climate models to more accurately understand how species and/or communities will respond to a changing environment.

Preliminary results from the hydrodynamic element of the 1994 entrapment zone study

USGS Publications Warehouse

Burau, J.R.; Stacey, M.; Gartner, J.W.

1995-01-01

This article discusses preliminary results from analyses of USGS hydrodynamic data collected as part of the 1994 Interagency Ecological Program entrapment zone study. The USGS took part in three 30-hour cruises and deployed instruments for measuring currents and salinity from April to June. This article primarily focuses on the analysis of data from five Acoustic Doppler Current ProUers (ADCPs) deployed in Carquinez Strait, Suisun Bay, and the Western Delta. From these analyses a revised conceptual model of the hydrodynamics of the entrapment/null zone has evolved. The ideas discussed in this newsletter article are essentially working hypotheses, which are presented here to stimulate discussion and further analyses. In this article we discuss the currently-held conceptual model of entrapment and present data that are inconsistent with this conceptual model. Finally, we suggest a revised conceptual model that is consistent with all of the hydrodynamic data collected to date and describe how the 1995 study incorporates our revised conceptual model into its design.

Setting up recovery clinics and promoting service user involvement.

PubMed

John, Thomas

2017-06-22

Service user involvement in mental health has gained considerable momentum. Evidence from the literature suggests that it remains largely theoretical rather than being put into practice. The current nature of acute inpatient mental health units creates various challenges for nurses to put this concept into practice. Recovery clinics were introduced to bridge this gap and to promote service user involvement practice within the current care delivery model at Kent and Medway NHS and Social Care Partnership Trust. It has shaped new ways of working for nurses with a person-centred approach as its philosophy. Service users and nurses were involved in implementing a needs-led and bottom-up initiative using Kotter's change model. Initial results suggest that it has been successful in meeting its objectives evidenced through increased meaningful interactions and involvement in care by service users and carers. The clinics have gained wide recognition and have highlighted a need for further research into care delivery models to promote service user involvement in these units.

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

PubMed Central

Bennett, Eric J.; Rush, John; Gygi, Steven P.; Harper, J. Wade

2010-01-01

Dynamic reorganization of signaling systems frequently accompany pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking. Here, we report the development of a quantitative proteomics platform centered on multiplex Absolute Quantification (AQUA) technology to elucidate the architecture of the cullin-RING ubiquitin ligase (CRL) network and to evaluate current models of dynamic CRL remodeling. Current models suggest that CRL complexes are controlled by cycles of CRL deneddylation and CAND1 binding. Contrary to expectations, acute CRL inhibition with MLN4924, an inhibitor of the NEDD8-activating enzyme, does not result in a global reorganization of the CRL network. Examination of CRL complex stoichiometry reveals that, independent of cullin neddylation, a large fraction of cullins are assembled with adaptor modules while only a small fraction are associated with CAND1. These studies suggest an alternative model of CRL dynamicity where the abundance of adaptor modules, rather than cycles of neddylation and CAND1 binding, drives CRL network organization. PMID:21145461

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

PubMed

Bennett, Eric J; Rush, John; Gygi, Steven P; Harper, J Wade

2010-12-10

Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking. Here, we report the development of a quantitative proteomics platform centered on multiplex absolute quantification (AQUA) technology to elucidate the architecture of the cullin-RING ubiquitin ligase (CRL) network and to evaluate current models of dynamic CRL remodeling. Current models suggest that CRL complexes are controlled by cycles of CRL deneddylation and CAND1 binding. Contrary to expectations, acute CRL inhibition with MLN4924, an inhibitor of the NEDD8-activating enzyme, does not result in a global reorganization of the CRL network. Examination of CRL complex stoichiometry reveals that, independent of cullin neddylation, a large fraction of cullins are assembled with adaptor modules, whereas only a small fraction are associated with CAND1. These studies suggest an alternative model of CRL dynamicity where the abundance of adaptor modules, rather than cycles of neddylation and CAND1 binding, drives CRL network organization. Copyright © 2010 Elsevier Inc. All rights reserved.

Air Defense Initiative (ADI) Clutter Model

DTIC Science & Technology

1998-04-01

Pusey, P. N., 1976 , "A Model for Non-Rayleigh Sea Echo," IEEE AP- 24 , No.6, November 197 6 James, W. J., 1961, The Effect of the Weather in Eastern...system procurement. RADC has been involved in the development of clutter models for system procurements for many years. Between 1976 and 1979, RADC...performed measurements and suggested clutter models for the SEEK IGLOO ( 1976 ) and the SEEK FROST (1978-9) programs. Since 1980, current clutter models

The role of internal variability in prolonging the California drought

NASA Astrophysics Data System (ADS)

Buenning, N. H.; Stott, L. D.

2015-12-01

The current drought in California has been one of the driest on record. Using atmospheric general circulation models (AGCMs), recent studies have demonstrated that the low precipitation anomalies observed during the first three winters of the current drought are mostly attributable to changes in sea surface temperature (SST) and sea ice forcing. Here we show through AGCM simulations that the fourth and latest winter of the current drought is not attributable to SST and sea ice forcing, but instead a consequence of higher internal variability. Using the Global Spectral Model (GSM) we demonstrate how the surface forcing reproduces dry conditions over California for the first three winters of the current drought, similar to what other models produced. However, when forced with the SST and sea ice conditions for the winter of 2014-2015, GSM robustly simulates high precipitation conditions over California. This significantly differs with observed precipitation anomalies, which suggests a model deficiency or large influence of internal variability within the climate system during the winter of 2014-2015. Ensemble simulations with 234 realizations reveal that the surface forcing created a broader range of precipitation possibilities over California. Thus, the surface forcing caused a greater degree of internal variations, which was driven by a reduced latitudinal temperature gradient and amplified planetary waves over the Pacific. Similar amplified waves are also seen in 21st century climate projections of upper-level geopotential heights, suggesting that 21st century precipitation over California will become more variable and increasingly difficult to predict on seasonal timescales. When an El Nino pattern is applied to the surface forcing the precipitation further increases and the variance amongst model realizations is reduced, which indicates a strong likelihood of an anomalously wet 2015-2016 winter season.

Heuristics for the Hodgkin-Huxley system.

PubMed

Hoppensteadt, Frank

2013-09-01

Hodgkin and Huxley (HH) discovered that voltages control ionic currents in nerve membranes. This led them to describe electrical activity in a neuronal membrane patch in terms of an electronic circuit whose characteristics were determined using empirical data. Due to the complexity of this model, a variety of heuristics, including relaxation oscillator circuits and integrate-and-fire models, have been used to investigate activity in neurons, and these simpler models have been successful in suggesting experiments and explaining observations. Connections between most of the simpler models had not been made clear until recently. Shown here are connections between these heuristics and the full HH model. In particular, we study a new model (Type III circuit): It includes the van der Pol-based models; it can be approximated by a simple integrate-and-fire model; and it creates voltages and currents that correspond, respectively, to the h and V components of the HH system. Copyright © 2012 Elsevier Inc. All rights reserved.

Coaching: a different approach to the nursing dilemma.

PubMed

Stedman, Martha E; Nolan, Thomas L

2007-01-01

While the current nursing shortage continues, many new approaches from sign-on bonuses to "fast track training" are being suggested and implemented to ameliorate the situation. Yet, even with these expanded opportunities turnover is still too high. Recent studies suggest embedded factors called fit, links, and sacrifice exist between the employer and employees including nurses that account for current employees staying on their job. Creating a better understanding of embedded issues and creating an open but confidential environment to deal with conflict issues and job problems is suggested as a way to reduce turnover. A specific issue such as an unfavorable job assignment or more complex issues such as unmet expectations can cause conflict and job dissatisfaction. It is suggested that a coaching model can be used to understand the issues that create conflict and provide a method for resolution of job dissatisfaction.

Modelling stream aquifer seepage in an alluvial aquifer: an improved loosing-stream package for MODFLOW

NASA Astrophysics Data System (ADS)

Osman, Yassin Z.; Bruen, Michael P.

2002-07-01

Seepage from a stream, which partially penetrates an unconfined alluvial aquifer, is studied for the case when the water table falls below the streambed level. Inadequacies are identified in current modelling approaches to this situation. A simple and improved method of incorporating such seepage into groundwater models is presented. This considers the effect on seepage flow of suction in the unsaturated part of the aquifer below a disconnected stream and allows for the variation of seepage with water table fluctuations. The suggested technique is incorporated into the saturated code MODFLOW and is tested by comparing its predictions with those of a widely used variably saturated model, SWMS_2D simulating water flow and solute transport in two-dimensional variably saturated media. Comparisons are made of both seepage flows and local mounding of the water table. The suggested technique compares very well with the results of variably saturated model simulations. Most currently used approaches are shown to underestimate the seepage and associated local water table mounding, sometimes substantially. The proposed method is simple, easy to implement and requires only a small amount of additional data about the aquifer hydraulic properties.

The Periodic Flapping and Breathing of Saturn's Magnetodisk During Equinox

NASA Astrophysics Data System (ADS)

Sorba, A. M.; Achilleos, N.; Guio, P.; Arridge, C. S.; Dougherty, M. K.; Sergis, N.

2017-12-01

Periodic variations have been observed in many field and particle properties in Saturn's magnetosphere, modulated at a period close to the planetary rotation rate. Magnetic field observations by Cassini's magnetometer instrument suggest that in the outer magnetosphere (beyond 12 Saturn radii) Saturn's current sheet is periodically displaced with respect to the rotational equator, to a first approximation acting as a rotating, tilted disk. This manifests as a `flapping' mode when observed by the spacecraft. Recent studies suggest the magnetosphere also has a `breathing' mode, expanding and contracting with a period close to the planetary rotation rate. We model these two modes in tandem by combining a global, geometrical model of a tilted and rippled current sheet with a local, force-balance model of Saturn's magnetodisk, accounting for the magnetospheric size and hot plasma content. We simulate the breathing behavior by introducing an azimuthal dependence of the system size. We fit Cassini magnetometer data acquired on equatorial orbits from 23 Oct - 17 Dec 2009 (Revs 120-122), close to Saturn equinox, in order that seasonal effects on the current sheet are minimised. We find that our model characterises well the amplitude and phase of the oscillations in the data, for those passes that show clear periodic signatures in the field. In particular, the Bθ (meridional) component can only be characterised when the breathing mode is included. This study introduces calculations for an oscillating boundary under conditions of constant solar wind dynamic pressure, which provide a good basis for understanding the complex relationship between current sheet dynamics and the periodic field perturbations.

Numerical simulations and observations of surface wave fields under an extreme tropical cyclone

USGS Publications Warehouse

Fan, Y.; Ginis, I.; Hara, T.; Wright, C.W.; Walsh, E.J.

2009-01-01

The performance of the wave model WAVEWATCH III under a very strong, category 5, tropical cyclone wind forcing is investigated with different drag coefficient parameterizations and ocean current inputs. The model results are compared with field observations of the surface wave spectra from an airborne scanning radar altimeter, National Data Buoy Center (NDBC) time series, and satellite altimeter measurements in Hurricane Ivan (2004). The results suggest that the model with the original drag coefficient parameterization tends to overestimate the significant wave height and the dominant wavelength and produces a wave spectrum with narrower directional spreading. When an improved drag parameterization is introduced and the wave-current interaction is included, the model yields an improved forecast of significant wave height, but underestimates the dominant wavelength. When the hurricane moves over a preexisting mesoscale ocean feature, such as the Loop Current in the Gulf of Mexico or a warm-and cold-core ring, the current associated with the feature can accelerate or decelerate the wave propagation and significantly modulate the wave spectrum. ?? 2009 American Meteorological Society.

Assessing the performance of formulations for nonlinear feedback of surface gravity waves on ocean currents over coastal waters

NASA Astrophysics Data System (ADS)

Wang, Pengcheng; Sheng, Jinyu; Hannah, Charles

2017-08-01

This study presents applications of a two-way coupled wave-circulation modelling system over coastal waters, with a special emphasis of performance assessments of two different methods for nonlinear feedback of ocean surface gravity waves on three-dimensional (3D) ocean currents. These two methods are the vortex force (VF) formulation suggested by Bennis et al. (2011) and the latest version of radiation stress (RS) formulation suggested by Mellor (2015). The coupled modelling system is first applied to two idealized test cases of surf-zone scales to validate implementations of these two methods in the coupled wave-circulation system. Model results show that the latest version of RS has difficulties in producing the undertow over the surf zone. The coupled system is then applied to Lunenburg Bay (LB) of Nova Scotia during Hurricane Juan in 2003. The coupled system using both the VF and RS formulations generates much stronger and more realistic 3D circulation in the Bay during Hurricane Juan than the circulation-only model, demonstrating the importance of surface wave forces to the 3D ocean circulation over coastal waters. However, the RS formulation generates some weak unphysical currents outside the wave breaking zone due to a less reasonable representation for the vertical distribution of the RS gradients over a slopping bottom. These weak unphysical currents are significantly magnified in a two-way coupled system when interacting with large surface waves, degrading the model performance in simulating currents at one observation site. Our results demonstrate that the VF formulation with an appropriate parameterization of wave breaking effects is able to produce reasonable results for applications over coastal waters during extreme weather events. The RS formulation requires a complex wave theory rather than the linear wave theory for the approximation of a vertical RS term to improve its performance under both breaking and non-breaking wave conditions.

Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study.

PubMed

Datta, Abhishek; Dmochowski, Jacek P; Guleyupoglu, Berkan; Bikson, Marom; Fregni, Felipe

2013-01-15

The field of non-invasive brain stimulation has developed significantly over the last two decades. Though two techniques of noninvasive brain stimulation--transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)--are becoming established tools for research in neuroscience and for some clinical applications, related techniques that also show some promising clinical results have not been developed at the same pace. One of these related techniques is cranial electrotherapy stimulation (CES), a class of transcranial pulsed current stimulation (tPCS). In order to understand further the mechanisms of CES, we aimed to model CES using a magnetic resonance imaging (MRI)-derived finite element head model including cortical and also subcortical structures. Cortical electric field (current density) peak intensities and distributions were analyzed. We evaluated different electrode configurations of CES including in-ear and over-ear montages. Our results confirm that significant amounts of current pass the skull and reach cortical and subcortical structures. In addition, depending on the montage, induced currents at subcortical areas, such as midbrain, pons, thalamus and hypothalamus are of similar magnitude than that of cortical areas. Incremental variations of electrode position on the head surface also influence which cortical regions are modulated. The high-resolution modeling predictions suggest that details of electrode montage influence current flow through superficial and deep structures. Finally we present laptop based methods for tPCS dose design using dominant frequency and spherical models. These modeling predictions and tools are the first step to advance rational and optimized use of tPCS and CES. Copyright © 2012 Elsevier Inc. All rights reserved.

Local Homing Navigation Based on the Moment Model for Landmark Distribution and Features

PubMed Central

Lee, Changmin; Kim, DaeEun

2017-01-01

For local homing navigation, an agent is supposed to return home based on the surrounding environmental information. According to the snapshot model, the home snapshot and the current view are compared to determine the homing direction. In this paper, we propose a novel homing navigation method using the moment model. The suggested moment model also follows the snapshot theory to compare the home snapshot and the current view, but the moment model defines a moment of landmark inertia as the sum of the product of the feature of the landmark particle with the square of its distance. The method thus uses range values of landmarks in the surrounding view and the visual features. The center of the moment can be estimated as the reference point, which is the unique convergence point in the moment potential from any view. The homing vector can easily be extracted from the centers of the moment measured at the current position and the home location. The method effectively guides homing direction in real environments, as well as in the simulation environment. In this paper, we take a holistic approach to use all pixels in the panoramic image as landmarks and use the RGB color intensity for the visual features in the moment model in which a set of three moment functions is encoded to determine the homing vector. We also tested visual homing or the moment model with only visual features, but the suggested moment model with both the visual feature and the landmark distance shows superior performance. We demonstrate homing performance with various methods classified by the status of the feature, the distance and the coordinate alignment. PMID:29149043

Modeling the Cost-Effectiveness of Alternative Upper Age Limits for Breast Cancer Screening in England and Wales.

PubMed

Rafia, Rachid; Brennan, Alan; Madan, Jason; Collins, Karen; Reed, Malcolm W R; Lawrence, Gill; Robinson, Thompson; Greenberg, David; Wyld, Lynda

2016-06-01

Currently in the United Kingdom, the National Health Service (NHS) Breast Screening Programme invites all women for triennial mammography between the ages of 47 and 73 years (the extension to 47-50 and 70-73 years is currently examined as part of a randomized controlled trial). The benefits and harms of screening in women 70 years and older, however, are less well documented. The aim of this study was to examine whether extending screening to women older than 70 years would represent a cost-effective use of NHS resources and to identify the upper age limit at which screening mammography should be extended in England and Wales. A mathematical model that allows the impact of screening policies on cancer diagnosis and subsequent management to be assessed was built. The model has two parts: a natural history model of the progression of breast cancer up to discovery and a postdiagnosis model of treatment, recurrence, and survival. The natural history model was calibrated to available data and compared against published literature. The management of breast cancer at diagnosis was taken from registry data and valued using official UK tariffs. The model estimated that screening would lead to overdiagnosis in 6.2% of screen-detected women at the age of 72 years, increasing up to 37.9% at the age of 90 years. Under commonly quoted willingness-to-pay thresholds in the United Kingdom, our study suggests that an extension to screening up to the age of 78 years represents a cost-effective strategy. This study provides encouraging findings to support the extension of the screening program to older ages and suggests that further extension of the UK NHS Breast Screening Programme up to age 78 years beyond the current upper age limit of 73 years could be potentially cost-effective according to current NHS willingness-to-pay thresholds. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Risk Profiling May Improve Lung Cancer Screening

Cancer.gov

A new modeling study suggests that individualized, risk-based selection of ever-smokers for lung cancer screening may prevent more lung cancer deaths and improve the effectiveness and efficiency of screening compared with current screening recommendations

A mathematical model for DNA

NASA Astrophysics Data System (ADS)

Sepehri, Alireza

Recently, some authors have shown that a DNA molecule produces electromagnetic signals and communicates with other DNA molecules or other molecules. In fact, a DNA acts like a receiver or transmitter of radio waves. In this paper, we suggest a mathematical model for the DNA molecule and use of its communication to cure some diseases like cancer. In this model, first, by using concepts from string theory and M-theory, we calculate the energy of a DNA in terms of interactions between free electrons and bound electrons. We show that when a DNA is damaged, its energy changes and an extra current is produced. This extra current causes the electromagnetic signals of a damaged DNA molecule to be different when compared to the electromagnetic signals of a normal DNA molecule. The electromagnetic signals of a damaged DNA molecule induce an extra current in a normal DNA molecule and lead to its destruction. By sending crafted electromagnetic signals to normal DNA molecules and inducing an opposite current with respect to this extra current, we can prevent the destruction of normal DNA. Finally, we argue that the type of packing of DNA in chromosomes of men and women is different. This causes radiated waves from DNAs of men and women to have opposite signs and cancel the effect of each other in a pair. Using this property, we suggest another mechanism to cancel the effect of extra waves, which are produced by DNAs in cancer cells of a male or a female, by extra waves which are produced by DNAs in similar cells of a female or a male and prevent the progression of the disease.

Hyperpolarization-Activated Current Induces Period-Doubling Cascades and Chaos in a Cold Thermoreceptor Model

PubMed Central

Xu, Kesheng; Maidana, Jean P.; Caviedes, Mauricio; Quero, Daniel; Aguirre, Pablo; Orio, Patricio

2017-01-01

In this article, we describe and analyze the chaotic behavior of a conductance-based neuronal bursting model. This is a model with a reduced number of variables, yet it retains biophysical plausibility. Inspired by the activity of cold thermoreceptors, the model contains a persistent Sodium current, a Calcium-activated Potassium current and a hyperpolarization-activated current (Ih) that drive a slow subthreshold oscillation. Driven by this oscillation, a fast subsystem (fast Sodium and Potassium currents) fires action potentials in a periodic fashion. Depending on the parameters, this model can generate a variety of firing patterns that includes bursting, regular tonic and polymodal firing. Here we show that the transitions between different firing patterns are often accompanied by a range of chaotic firing, as suggested by an irregular, non-periodic firing pattern. To confirm this, we measure the maximum Lyapunov exponent of the voltage trajectories, and the Lyapunov exponent and Lempel-Ziv's complexity of the ISI time series. The four-variable slow system (without spiking) also generates chaotic behavior, and bifurcation analysis shows that this is often originated by period doubling cascades. Either with or without spikes, chaos is no longer generated when the Ih is removed from the system. As the model is biologically plausible with biophysically meaningful parameters, we propose it as a useful tool to understand chaotic dynamics in neurons. PMID:28344550

The factors influencing nonlinear characteristics of the short-circuit current in dye-sensitized solar cells investigated by a numerical model.

PubMed

Shi, Yushuai; Dong, Xiandui

2013-06-24

A numerical model for interpretation of the light-intensity-dependent nonlinear characteristics of the short-circuit current in dye-sensitized solar cells is suggested. The model is based on the continuity equation and includes the influences of the nongeminate recombination between electrons and electron acceptors in the electrolyte and the geminate recombination between electrons and oxidized dye molecules. The influences of the order and rate constant of the nongeminate recombination reaction, the light-absorption coefficient of the dye, the film thickness, the rate constant of geminate recombination, and the regeneration rate constant on the nonlinear characteristics of the short-circuit current are simulated and analyzed. It is proposed that superlinear and sublinear characteristics of the short-circuit current should be attributed to low electron-collection efficiency and low dye-regeneration efficiency, respectively. These results allow a deep understanding of the origin of the nonlinear characteristics of the short-circuit current in solar cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modeling of phonon scattering in n-type nanowire transistors using one-shot analytic continuation technique

NASA Astrophysics Data System (ADS)

Bescond, Marc; Li, Changsheng; Mera, Hector; Cavassilas, Nicolas; Lannoo, Michel

2013-10-01

We present a one-shot current-conserving approach to model the influence of electron-phonon scattering in nano-transistors using the non-equilibrium Green's function formalism. The approach is based on the lowest order approximation (LOA) to the current and its simplest analytic continuation (LOA+AC). By means of a scaling argument, we show how both LOA and LOA+AC can be easily obtained from the first iteration of the usual self-consistent Born approximation (SCBA) algorithm. Both LOA and LOA+AC are then applied to model n-type silicon nanowire field-effect-transistors and are compared to SCBA current characteristics. In this system, the LOA fails to describe electron-phonon scattering, mainly because of the interactions with acoustic phonons at the band edges. In contrast, the LOA+AC still well approximates the SCBA current characteristics, thus demonstrating the power of analytic continuation techniques. The limits of validity of LOA+AC are also discussed, and more sophisticated and general analytic continuation techniques are suggested for more demanding cases.

Opting out and Opting in: Understanding the Complexities of Women's Career Transitions

ERIC Educational Resources Information Center

Cabrera, Elizabeth F.

2007-01-01

Purpose: This study aims to explore the reasons why women are leaving the workplace. Are they opting out of the workforce to stay at home with their children as current media reports suggest, or are the reasons more complex as the Kaleidoscope Career Model (KCM) suggests? A second objective is to examine whether or not women's primary career…

Mathematical modeling of HIV prevention measures including pre-exposure prophylaxis on HIV incidence in South Korea.

PubMed

Kim, Sun Bean; Yoon, Myoungho; Ku, Nam Su; Kim, Min Hyung; Song, Je Eun; Ahn, Jin Young; Jeong, Su Jin; Kim, Changsoo; Kwon, Hee-Dae; Lee, Jeehyun; Smith, Davey M; Choi, Jun Yong

2014-01-01

Multiple prevention measures have the possibility of impacting HIV incidence in South Korea, including early diagnosis, early treatment, and pre-exposure prophylaxis (PrEP). We investigated how each of these interventions could impact the local HIV epidemic, especially among men who have sex with men (MSM), who have become the major risk group in South Korea. A mathematical model was used to estimate the effects of each these interventions on the HIV epidemic in South Korea over the next 40 years, as compared to the current situation. We constructed a mathematical model of HIV infection among MSM in South Korea, dividing the MSM population into seven groups, and simulated the effects of early antiretroviral therapy (ART), early diagnosis, PrEP, and combination interventions on the incidence and prevalence of HIV infection, as compared to the current situation that would be expected without any new prevention measures. Overall, the model suggested that the most effective prevention measure would be PrEP. Even though PrEP effectiveness could be lessened by increased unsafe sex behavior, PrEP use was still more beneficial than the current situation. In the model, early diagnosis of HIV infection was also effectively decreased HIV incidence. However, early ART did not show considerable effectiveness. As expected, it would be most effective if all interventions (PrEP, early diagnosis and early treatment) were implemented together. This model suggests that PrEP and early diagnosis could be a very effective way to reduce HIV incidence in South Korea among MSM.

Mathematical Modeling of HIV Prevention Measures Including Pre-Exposure Prophylaxis on HIV Incidence in South Korea

PubMed Central

Kim, Sun Bean; Yoon, Myoungho; Ku, Nam Su; Kim, Min Hyung; Song, Je Eun; Ahn, Jin Young; Jeong, Su Jin; Kim, Changsoo; Kwon, Hee-Dae; Lee, Jeehyun; Smith, Davey M.; Choi, Jun Yong

2014-01-01

Background Multiple prevention measures have the possibility of impacting HIV incidence in South Korea, including early diagnosis, early treatment, and pre-exposure prophylaxis (PrEP). We investigated how each of these interventions could impact the local HIV epidemic, especially among men who have sex with men (MSM), who have become the major risk group in South Korea. A mathematical model was used to estimate the effects of each these interventions on the HIV epidemic in South Korea over the next 40 years, as compared to the current situation. Methods We constructed a mathematical model of HIV infection among MSM in South Korea, dividing the MSM population into seven groups, and simulated the effects of early antiretroviral therapy (ART), early diagnosis, PrEP, and combination interventions on the incidence and prevalence of HIV infection, as compared to the current situation that would be expected without any new prevention measures. Results Overall, the model suggested that the most effective prevention measure would be PrEP. Even though PrEP effectiveness could be lessened by increased unsafe sex behavior, PrEP use was still more beneficial than the current situation. In the model, early diagnosis of HIV infection was also effectively decreased HIV incidence. However, early ART did not show considerable effectiveness. As expected, it would be most effective if all interventions (PrEP, early diagnosis and early treatment) were implemented together. Conclusions This model suggests that PrEP and early diagnosis could be a very effective way to reduce HIV incidence in South Korea among MSM. PMID:24662776

Reduced Current Spread by Concentric Electrodes in Transcranial Electrical Stimulation (tES).

PubMed

Bortoletto, M; Rodella, C; Salvador, R; Miranda, P C; Miniussi, C

2016-01-01

We propose the use of a new montage for transcranial direct current stimulation (tDCS), called concentric electrodes tDCS (CE-tDCS), involving two concentric round electrodes that may improve stimulation focality. To test efficacy and focality of CE-tDCS, we modelled the current distribution and tested physiological effects on cortical excitability. Motor evoked potentials (MEPs) from first dorsal interosseous (FDI) and abductor digiti minimi (ADM) were recorded before and after the delivery of anodal, cathodal and sham stimulation on the FDI hotspot for 10 minutes. MEP amplitude of FDI increased after anodal-tDCS and decreased after cathodal-tDCS, supporting the efficacy of CE-tDCS in modulating cortical excitability. Moreover, modelled current distribution and no significant effects of stimulation on MEP amplitude of ADM suggest high focality of CE-tDCS. CE-tDCS may allow a better control of current distribution and may represent a novel tool for applying tDCS and other transcranial current stimulation approaches. Copyright © 2016 Elsevier Inc. All rights reserved.

A Season of Change: How Science Librarians Can Remain Relevant with Open Access and Scholarly Communications Initiatives

ERIC Educational Resources Information Center

Brown, Elizabeth

2009-01-01

The current rate of change suggests scholarly communications issues such as new publication models and technology to connect library and research tools is expected to continue into the foreseeable future. As models evolve, standards develop, and scientists evolve in their communication patterns, librarians will need to embrace transitional…

Computation of turbulent flows-state-of-the-art, 1970

NASA Technical Reports Server (NTRS)

Reynolds, W. C.

1972-01-01

The state-of-the-art of turbulent flow computation is surveyed. The formulations were generalized to increase the range of their applicability, and the excitement of current debate on equation models was brought into the review. Some new ideas on the modeling of the pressure-strain term in the Reynolds stress equations are also suggested.

The Kalamazoo Promise: A Study of Philanthropy's Increasing Role in the American Economy and Education

ERIC Educational Resources Information Center

Strickland, Shelley

2009-01-01

This paper explores the Kalamazoo Promise through the lens of the existing literature on other privately funded scholarships programs and the broader advancement knowledge base. The author concludes that current research does not adequately explain the Promise, and suggests a conceptual model--a logic model--to be used in philanthropy evaluation.

Unvorgreifliche Gedanken, betreffend die Ausuebung und Verbesserung des Uebersetzungsunterrichts Englisch-Deutsch. (Modest Thoughts on the Use and Improvement of Training in Translation -- English to German).

ERIC Educational Resources Information Center

Haber, Bernd K.

1978-01-01

Surveys current practice in teaching translation and finds it faulty. An almost mathematical model of translation strategy is suggested for upper-level students of English who can use a monolingual dictionary. Two sample texts for testing the model are appended. (IFS/WGA)

Parameter extraction and transistor models

NASA Technical Reports Server (NTRS)

Rykken, Charles; Meiser, Verena; Turner, Greg; Wang, QI

1985-01-01

Using specified mathematical models of the MOSFET device, the optimal values of the model-dependent parameters were extracted from data provided by the Jet Propulsion Laboratory (JPL). Three MOSFET models, all one-dimensional were used. One of the models took into account diffusion (as well as convection) currents. The sensitivity of the models was assessed for variations of the parameters from their optimal values. Lines of future inquiry are suggested on the basis of the behavior of the devices, of the limitations of the proposed models, and of the complexity of the required numerical investigations.

Analyzing the Implications of Climate Data on Plant Hardiness Zones for Green Infrastructure Planning: Case Study of Knoxville, Tennessee and Surrounding Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sylvester, Linda M.; Omitaomu, Olufemi A.; Parish, Esther S.

Downscaled climate data for Knoxville, Tennessee and the surrounding region were used to investigate future changing Plant Hardiness Zones due to climate change. The methodology used is the same as the US Department of Agriculture (USDA), well-known for their creation of the standard Plant Hardiness Zone map used by gardeners and planners. USDA data were calculated from observed daily data for 1976–2005. The modeled climate data for the past is daily data from 1980-2005 and the future data is projected for 2025–2050. The average of all the modeled annual extreme minimums for each time period of interest was calculated. Eachmore » 1 km raster cell was placed into zone categories based on temperature, using the same criteria and categories of the USDA. The individual models vary between suggesting little change to the Plant Hardiness Zones to suggesting Knoxville moves into the next two Hardiness Zones. But overall, the models suggest moving into the next warmer Zone. USDA currently has the Knoxville area categorized as Zone 7a. None of the Zones calculated from the climate data models placed Knoxville in Zone 7a for the similar time period. The models placed Knoxville in a cooler Hardiness Zone and projected the area to increase to Zone 7. The modeled temperature data appears to be slightly cooler than the actual temperature data and this may explain the zone discrepancy. However, overall Knoxville is projected to increase to the next warmer Zone. As the modeled data has Knoxville, overall, moving from Zone 6 to Zone 7, it can be inferred that Knoxville, Tennessee may increase from their current Zone 7 to Zone 8.« less

Mediterranea Forecasting System: a focus on wave-current coupling

NASA Astrophysics Data System (ADS)

Clementi, Emanuela; Delrosso, Damiano; Pistoia, Jenny; Drudi, Massimiliano; Fratianni, Claudia; Grandi, Alessandro; Pinardi, Nadia; Oddo, Paolo; Tonani, Marina

2016-04-01

The Mediterranean Forecasting System (MFS) is a numerical ocean prediction system that produces analyses, reanalyses and short term forecasts for the entire Mediterranean Sea and its Atlantic Ocean adjacent areas. MFS became operational in the late 90's and has been developed and continuously improved in the framework of a series of EU and National funded programs and is now part of the Copernicus Marine Service. The MFS is composed by the hydrodynamic model NEMO (Nucleus for European Modelling of the Ocean) 2-way coupled with the third generation wave model WW3 (WaveWatchIII) implemented in the Mediterranean Sea with 1/16 horizontal resolution and forced by ECMWF atmospheric fields. The model solutions are corrected by the data assimilation system (3D variational scheme adapted to the oceanic assimilation problem) with a daily assimilation cycle, using a background error correlation matrix varying seasonally and in different sub-regions of the Mediterranean Sea. The focus of this work is to present the latest modelling system upgrades and the related achieved improvements. In order to evaluate the performance of the coupled system a set of experiments has been built by coupling the wave and circulation models that hourly exchange the following fields: the sea surface currents and air-sea temperature difference are transferred from NEMO model to WW3 model modifying respectively the mean momentum transfer of waves and the wind speed stability parameter; while the neutral drag coefficient computed by WW3 model is passed to NEMO that computes the turbulent component. In order to validate the modelling system, numerical results have been compared with in-situ and remote sensing data. This work suggests that a coupled model might be capable of a better description of wave-current interactions, in particular feedback from the ocean to the waves might assess an improvement on the prediction capability of wave characteristics, while suggests to proceed toward a fully coupled modelling system in order to achieve stronger enhancements of the hydrodynamic fields.

Electric currents induced by twisted light in Quantum Rings.

PubMed

Quinteiro, G F; Berakdar, J

2009-10-26

We theoretically investigate the generation of electric currents in quantum rings resulting from the optical excitation with twisted light. Our model describes the kinetics of electrons in a two-band model of a semiconductor-based mesoscopic quantum ring coupled to light having orbital angular momentum (twisted light). We find the analytical solution, which exhibits a "circular" photon-drag effect and an induced magnetization, suggesting that this system is the circular analog of that of a bulk semiconductor excited by plane waves. For realistic values of the electric field and material parameters, the computed electric current can be as large as microA; from an applied perspective, this opens new possibilities to the optical control of the magnetization in semiconductors.

Source analysis of MEG activities during sleep (abstract)

NASA Astrophysics Data System (ADS)

Ueno, S.; Iramina, K.

1991-04-01

The present study focuses on magnetic fields of the brain activities during sleep, in particular on K-complexes, vertex waves, and sleep spindles in human subjects. We analyzed these waveforms based on both topographic EEG (electroencephalographic) maps and magnetic fields measurements, called MEGs (magnetoencephalograms). The components of magnetic fields perpendicular to the surface of the head were measured using a dc SQUID magnetometer with a second derivative gradiometer. In our computer simulation, the head is assumed to be a homogeneous spherical volume conductor, with electric sources of brain activity modeled as current dipoles. Comparison of computer simulations with the measured data, particularly the MEG, suggests that the source of K-complexes can be modeled by two current dipoles. A source for the vertex wave is modeled by a single current dipole which orients along the body axis out of the head. By again measuring the simultaneous MEG and EEG signals, it is possible to uniquely determine the orientation of this dipole, particularly when it is tilted slightly off-axis. In sleep stage 2, fast waves of magnetic fields consistently appeared, but EEG spindles appeared intermittently. The results suggest that there exist sources which are undetectable by electrical measurement but are detectable by magnetic-field measurement. Such source can be described by a pair of opposing dipoles of which directions are oppositely oriented.

PARAMETER MONITORING FOR REAL-TIME ELECTROSTATIC PRECIPITATOR TROUBLESHOOTING

EPA Science Inventory

The paper discusses detailed numerical calculations of particle charge and extinction coefficient performed using current models. The results suggest that information about rapping reentrainment, back corona, and, possibly, sulfuric acid condensation can be gained from simultaneo...

A Particle and Energy Balance Model of the Orificed Hollow Cathode

NASA Technical Reports Server (NTRS)

Domonkos, Matthew T.

2002-01-01

A particle and energy balance model of orificed hollow cathodes was developed to assist in cathode design. The model presented here is an ensemble of original work by the author and previous work by others. The processes in the orifice region are considered to be one of the primary drivers in determining cathode performance, since the current density was greatest in this volume (up to 1.6 x 10(exp 8) A/m2). The orifice model contains comparatively few free parameters, and its results are used to bound the free parameters for the insert model. Next, the insert region model is presented. The sensitivity of the results to the free parameters is assessed, and variation of the free parameters in the orifice dominates the calculated power consumption and plasma properties. The model predictions are compared to data from a low-current orificed hollow cathode. The predicted power consumption exceeds the experimental results. Estimates of the plasma properties in the insert region overlap Langmuir probe data, and the predicted orifice plasma suggests the presence of one or more double layers. Finally, the model is used to examine the operation of higher current cathodes.

Refining Trait Resilience: Identifying Engineering, Ecological, and Adaptive Facets from Extant Measures of Resilience

PubMed Central

Maltby, John; Day, Liz; Hall, Sophie

2015-01-01

The current paper presents a new measure of trait resilience derived from three common mechanisms identified in ecological theory: Engineering, Ecological and Adaptive (EEA) resilience. Exploratory and confirmatory factor analyses of five existing resilience scales suggest that the three trait resilience facets emerge, and can be reduced to a 12-item scale. The conceptualization and value of EEA resilience within the wider trait and well-being psychology is illustrated in terms of differing relationships with adaptive expressions of the traits of the five-factor personality model and the contribution to well-being after controlling for personality and coping, or over time. The current findings suggest that EEA resilience is a useful and parsimonious model and measure of trait resilience that can readily be placed within wider trait psychology and that is found to contribute to individual well-being. PMID:26132197

A nurse staffing analysis at the largest hospital in the Gulf region

NASA Astrophysics Data System (ADS)

Louly, M.; Gharbi, A.; Azaiez, M. N.; Bouras, A.

2014-12-01

The paper considers a staffing problem at a local hospital. The managers consider they are understaffed and try to overwhelm the staffing deficit problem through overtime, rather than hiring additional nurses. However, the huge amount of allocated budget for overtime becomes a concern and needs some assessment, analysis and justification. The current hospital estimates suggests that the shortage at the hospital level corresponds to 300 full time equivalent (FTE) nurses, but the deficit is not basedon deep scientific approach. This paper deals with staffing model that provides the required scientific evidence on the deficit level. It also gives the accurate information on the overtime components. As a results, the suggested staffing model shows that some nursing units are unnecessarily overstaffed. Moreover, the current study reveals that the real deficit is of only 215 FTE resulting in a potential saving of 28%.

Fractal electrodynamics via non-integer dimensional space approach

NASA Astrophysics Data System (ADS)

Tarasov, Vasily E.

2015-09-01

Using the recently suggested vector calculus for non-integer dimensional space, we consider electrodynamics problems in isotropic case. This calculus allows us to describe fractal media in the framework of continuum models with non-integer dimensional space. We consider electric and magnetic fields of fractal media with charges and currents in the framework of continuum models with non-integer dimensional spaces. An application of the fractal Gauss's law, the fractal Ampere's circuital law, the fractal Poisson equation for electric potential, and equation for fractal stream of charges are suggested. Lorentz invariance and speed of light in fractal electrodynamics are discussed. An expression for effective refractive index of non-integer dimensional space is suggested.

A finite element model for tides and resonance along the north coast of British Columbia

NASA Astrophysics Data System (ADS)

Foreman, M. G. G.; Henry, R. F.; Walters, R. A.; Ballantyne, V. A.

1993-02-01

A finite element, barotropic, tidal model is developed for the north coast of British Columbia. The model is run with eight tidal constituents and the results are compared with the Flather (1987) finite difference model, and with extensive tide gauge and current meter observations. Although the tidal potential, Earth tide, and loading tide are included in the forcing, their inclusion is shown to change the largest M2 amplitudes by only 2.5% and the largest K1 amplitudes by less than 1%. Root mean square differences between observed and calculated sea level amplitudes and phases are within 1.9 cm and 2.9° for all but one constituent, but the model currents do not in general, compare as favourably. The barotropic currents observed in Hecate Strait are reproduced well, but elsewhere evidence is shown that model inaccuracies are due to baroclinic effects. Tidal residual currents calculated by the model suggest the existence of eddies off the tip of Cape St. James, Cape Chacon, and around Goose Island and Learmonth Banks. The shallow water constituents in Hecate Strait are shown to have significant contributions from the constructive interference of signals propagating into Dixon Entrance and Queen Charlotte Sound. Using the model, the longest resonant period of the system is estimated to be 7.6 hours with an energy dissipation parameter, Q, of 9.5.

Evaluating Opportunities for Achieving Cost Efficiencies Through the Introduction of PrePex Device Male Circumcision in Adult VMMC Programs in Zambia and Zimbabwe.

PubMed

Vandament, Lyndsey; Chintu, Naminga; Yano, Nanako; Mugurungi, Owen; Tambatamba, Bushimbwa; Ncube, Gertrude; Xaba, Sinokuthemba; Mpasela, Felton; Muguza, Edward; Mangono, Tichakunda; Madidi, Ngonidzashe; Samona, Alick; Tagar, Elva; Hatzold, Karin

2016-06-01

Results from recent costing studies have put into question potential Voluntary Medical Male Circumcision (VMMC) cost savings with the introduction of the PrePex device. We evaluated the cost drivers and the overall unit cost of VMMC for a variety of service delivery models providing either surgical VMMC or both PrePex and surgery using current program data in Zimbabwe and Zambia. In Zimbabwe, 3 hypothetical PrePex only models were also included. For all models, clients aged 18 years and older were assumed to be medically eligible for PrePex and uptake was based on current program data from sites providing both methods. Direct costs included costs for consumables, including surgical VMMC kits for the forceps-guided method, device (US $12), human resources, demand creation, supply chain, waste management, training, and transport. Results for both countries suggest limited potential for PrePex to generate cost savings when adding the device to current surgical service delivery models. However, results for the hypothetical rural Integrated PrePex model in Zimbabwe suggest the potential for material unit cost savings (US $35 per VMMC vs. US $65-69 for existing surgical models). This analysis illustrates that models designed to leverage PrePex's advantages, namely the potential for integrating services in rural clinics and less stringent infrastructure requirements, may present opportunities for improved cost efficiency and service integration. Countries seeking to scale up VMMC in rural settings might consider integrating PrePex only MC services at the primary health care level to reduce costs while also increasing VMMC access and coverage.

Exploring the effects of overburden on the sublimation and transport of H2O on Iapetus

NASA Astrophysics Data System (ADS)

Rivera-Valentin, Edgard G.; Blackburn, David G.; Ulrich, Richard K.

2012-08-01

It has been shown through both measurements and simulations that there exists a measurable ice-free, porous, overburden overlaying water ice on Cassini Regio. Mass transfer through this porous media in a vacuum would occur in the Knudsen regime, which provides sublimation rates orders of magnitude smaller than Hertz-Langmuir sublimation. The availability of water ice for transport from this region is thus currently controlled by mass transfer through the dark material overburden. Thermal segregation suggests that Iapetus' polar regions have been brightened via ballistic transport of water and its subsequent cold trapping since exogenic deposition models predict dark high latitudes on the leading hemisphere. The limiting effect of the dark material on transport of water ice may thus greatly impact the current mass balance at the poles. The effects of the overburden on the global stability and transport of H2O is addressed in order to gain insight into its influence on the polar albedo distribution and current state of thermal segregation within the dark terrain. Results indicate that thermal segregation is currently an inactive or weak process within Cassini Regio, though it is an ongoing process at the inter-terrain regions. Modeling of polar accumulation suggests that even accounting for the current dark material cover within Cassini Regio there exists sufficient ballistically inbound water to overcome exogenic darkening mechanisms. Topographic effects on local albedo differences are also simulated to provide a more complete water stability study of Iapetus. Results suggest that topographically induced changes in heat flux may be sufficient to create the observed local albedo contrasts and also support ongoing dark exogenic deposition within Cassini Regio to explain the lack of bright slopes deep within the dark terrain.

Examining lag effects between industrial land development and regional economic changes: The Netherlands experience.

PubMed

Ustaoglu, Eda; Lavalle, Carlo

2017-01-01

In most empirical applications, forecasting models for the analysis of industrial land focus on the relationship between current values of economic parameters and industrial land use. This paper aims to test this assumption by focusing on the dynamic relationship between current and lagged values of the 'economic fundamentals' and industrial land development. Not much effort has yet been attributed to develop land forecasting models to predict the demand for industrial land except those applying static regressions or other statistical measures. In this research, we estimated a dynamic panel data model across 40 regions from 2000 to 2008 for the Netherlands to uncover the relationship between current and lagged values of economic parameters and industrial land development. Land-use regulations such as land zoning policies, and other land-use restrictions like natural protection areas, geographical limitations in the form of water bodies or sludge areas are expected to affect supply of land, which will in turn be reflected in industrial land market outcomes. Our results suggest that gross domestic product (GDP), industrial employment, gross value added (GVA), property price, and other parameters representing demand and supply conditions in the industrial market explain industrial land developments with high significance levels. It is also shown that contrary to the current values, lagged values of the economic parameters have more sound relationships with the industrial developments in the Netherlands. The findings suggest use of lags between selected economic parameters and industrial land use in land forecasting applications.

Examining lag effects between industrial land development and regional economic changes: The Netherlands experience

PubMed Central

Ustaoglu, Eda; Lavalle, Carlo

2017-01-01

In most empirical applications, forecasting models for the analysis of industrial land focus on the relationship between current values of economic parameters and industrial land use. This paper aims to test this assumption by focusing on the dynamic relationship between current and lagged values of the ‘economic fundamentals’ and industrial land development. Not much effort has yet been attributed to develop land forecasting models to predict the demand for industrial land except those applying static regressions or other statistical measures. In this research, we estimated a dynamic panel data model across 40 regions from 2000 to 2008 for the Netherlands to uncover the relationship between current and lagged values of economic parameters and industrial land development. Land-use regulations such as land zoning policies, and other land-use restrictions like natural protection areas, geographical limitations in the form of water bodies or sludge areas are expected to affect supply of land, which will in turn be reflected in industrial land market outcomes. Our results suggest that gross domestic product (GDP), industrial employment, gross value added (GVA), property price, and other parameters representing demand and supply conditions in the industrial market explain industrial land developments with high significance levels. It is also shown that contrary to the current values, lagged values of the economic parameters have more sound relationships with the industrial developments in the Netherlands. The findings suggest use of lags between selected economic parameters and industrial land use in land forecasting applications. PMID:28877204

A review of the ionospheric model for the long wave prediction capability

NASA Astrophysics Data System (ADS)

Ferguson, J. A.

1992-11-01

The Naval Command, Control, and Ocean Surveillance Center's Long Wave Prediction Capability (LWPC) has a built-in ionospheric model. The latter was defined after a review of the literature comparing measurements with calculations. Subsequent to this original specification of the ionospheric model in the LWPC, a new collection of data were obtained and analyzed. The new data were collected aboard a merchant ship named the Callaghan during a series of trans-Atlantic trips over a period of a year. This report presents a detailed analysis of the ionospheric model currently in use by the LWPC and the new model suggested by the shipboard measurements. We conclude that, although the fits to measurements are almost the same between the two models examined, the current LWPC model should be used because it is better than the new model for nighttime conditions at long ranges. This conclusion supports the primary use of the LWPC model for coverage assessment that requires a valid model at the limits of a transmitter's reception.

A nonlinear viscoelastic approach to durability predictions for polymer based composite structures

NASA Technical Reports Server (NTRS)

Brinson, Hal F.

1991-01-01

Current industry approaches for the durability assessment of metallic structures are briefly reviewed. For polymer based composite structures, it is suggested that new approaches must be adopted to include memory or viscoelastic effects which could lead to delayed failures that might not be predicted using current techniques. A durability or accelerated life assessment plan for fiber reinforced plastics (FRP) developed and documented over the last decade or so is reviewed and discussed. Limitations to the plan are outlined and suggestions to remove the limitations are given. These include the development of a finite element code to replace the previously used lamination theory code and the development of new specimen geometries to evaluate delamination failures. The new DCB model is reviewed and results are presented. Finally, it is pointed out that new procedures are needed to determine interfacial properties and current efforts underway to determine such properties are reviewed. Suggestions for additional efforts to develop a consistent and accurate durability predictive approach for FRP structures are outlined.

A nonlinear viscoelastic approach to durability predictions for polymer based composite structures

NASA Technical Reports Server (NTRS)

Brinson, Hal F.; Hiel, C. C.

1990-01-01

Current industry approaches for the durability assessment of metallic structures are briefly reviewed. For polymer based composite structures, it is suggested that new approaches must be adopted to include memory or viscoelastic effects which could lead to delayed failures that might not be predicted using current techniques. A durability or accelerated life assessment plan for fiber reinforced plastics (FRP) developed and documented over the last decade or so is reviewed and discussed. Limitations to the plan are outlined and suggestions to remove the limitations are given. These include the development of a finite element code to replace the previously used lamination theory code and the development of new specimen geometries to evaluate delamination failures. The new DCB model is reviewed and results are presented. Finally, it is pointed out that new procedures are needed to determine interfacial properties and current efforts underway to determine such properties are reviewed. Suggestions for additional efforts to develop a consistent and accurate durability predictive approach for FRP structures is outlined.

Wind and Wave Driven Nearshore Circulation at Cape Hatteras Point

NASA Astrophysics Data System (ADS)

Kumar, N.; Voulgaris, G.; Warner, J. C.; List, J. H.

2012-12-01

We have used a measurement and modeling approach to identify hydrodynamic processes responsible for alongshore transport of sediment that can support the maintenance of Diamond Shoals, NC, a large inner-shelf sedimentary convergent feature. As a part of Carolina Coastal Change Processes project, a one month field experiment was conducted around Cape Hatteras point during February, 2010. The instrumentation consisted of 15 acoustic current meters (measuring pressure and velocity profile) deployed in water depths varying from 3-10m and a very high frequency (VHF) beam forming radar system providing surface waves and currents with a resolution of 150 m and a spatial coverage of 10-15 km2. Analysis of field observation suggests that wind-driven circulation and littoral current dominate surf zone and inner shelf processes at least at an order higher than tidally rectified flows. However, the data analysis identified that relevant processes like non-linear advective acceleration, pressure gradient and vortex-force (due to interaction between wave-induced drift and mean flow vorticity), may be significant, but were not assessed accurately due to instrument location and accuracy. To obtain a deeper physical understanding of the hydrodynamics in this study-site, we applied a three-dimensional Coupled-Ocean-Atmosphere-Wave_Sediment-Transport (COAWST) numerical model. The COAWST modeling system is comprised of nested, coupled, three-dimensional ocean-circulation model (ROMS) and wave propagation model (SWAN), configured for the study site to simulate wave height, direction, period and mean current velocities (both Eulerian and Lagrangian). The nesting follows a two-way grid refinement process for the circulation module, and one-way for the wave model. The coarsest parent grid resolved processes on the spatial and temporal scales of mid-shelf to inner-shelf, and subsequent child grids evolved at inner-shelf and surf zone scales. Preliminary results show that the model successfully reproduces wind-driven circulation and littoral currents. Furthermore, model simulation provides evidence for (a) circulation pattern suggesting a mechanism for sediment movement from littoral zone to the Diamond Shoals complex; (b) Diamond shoals complex acting as independent coastline, which restricts the littoral currents to follow the coastline orientation around Cape Hatteras point. As a part of this study, simulated hydrodynamic parameters will be validated against field observations of wave height and direction and Eulerian velocities from acoustic current meters, and sea surface maps of wave height and Lagrangian flows provided by the VHF radar. Moreover, the model results will be analyzed to (a) identify the significance of the terms in momentum balance which are not estimated accurately through field observations; (b) provide a quasi-quantitative estimate of sediment transport contributing to shoal building process.

Current rectification for transport of room-temperature ionic liquids through conical nanopores

DOE PAGES

Jiang, Xikai; Liu, Ying; Qiao, Rui

2016-02-09

Here, we studied the transport of room-temperature ionic liquids (RTILs) through charged conical nanopores using a Landau-Ginzburg-type continuum model that takes steric effect and strong ion-ion correlations into account. When the surface charge is uniform on the pore wall, weak current rectification is observed. When the charge density near the pore base is removed, the ionic current is greatly suppressed under negative bias voltage while nearly unchanged under positive bias voltage, thereby leading to enhanced current rectification. These predictions agree qualitatively with prior experimental observations, and we elucidated them by analyzing the different components of the ionic current and themore » structural changes of electrical double layers (EDLs) at the pore tip under different bias voltages and surface charge patterns. These analyses reveal that the different modifications of the EDL structure near the pore tip by the positive and negative bias voltages cause the current rectification and the observed dependence on the distribution of surface charge on the pore wall. The fact that the current rectification phenomena are captured qualitatively by the simple model originally developed for describing EDLs at equilibrium conditions suggests that this model may be promising for understanding the ionic transport under nonequilibrium conditions when the EDL structure is strongly perturbed by external fields.« less

Computational modeling of transcranial direct current stimulation (tDCS) in obesity: Impact of head fat and dose guidelines☆

PubMed Central

Truong, Dennis Q.; Magerowski, Greta; Blackburn, George L.; Bikson, Marom; Alonso-Alonso, Miguel

2013-01-01

Recent studies show that acute neuromodulation of the prefrontal cortex with transcranial direct current stimulation (tDCS) can decrease food craving, attentional bias to food, and actual food intake. These data suggest potential clinical applications for tDCS in the field of obesity. However, optimal stimulation parameters in obese individuals are uncertain. One fundamental concern is whether a thick, low-conductivity layer of subcutaneous fat around the head can affect current density distribution and require dose adjustments during tDCS administration. The aim of this study was to investigate the role of head fat on the distribution of current during tDCS and evaluate whether dosing standards for tDCS developed for adult individuals in general are adequate for the obese population. We used MRI-derived high-resolution computational models that delineated fat layers in five human heads from subjects with body mass index (BMI) ranging from “normal-lean” to “super-obese” (20.9 to 53.5 kg/m2). Data derived from these simulations suggest that head fat influences tDCS current density across the brain, but its relative contribution is small when other components of head anatomy are added. Current density variability between subjects does not appear to have a direct and/or simple link to BMI. These results indicate that guidelines for the use of tDCS can be extrapolated to obese subjects without sacrificing efficacy and/or treatment safety; the recommended standard parameters can lead to the delivery of adequate current flow to induce neuromodulation of brain activity in the obese population. PMID:24159560

A quasi-static model of global atmospheric electricity. I - The lower atmosphere

NASA Technical Reports Server (NTRS)

Hays, P. B.; Roble, R. G.

1979-01-01

A quasi-steady model of global lower atmospheric electricity is presented. The model considers thunderstorms as dipole electric generators that can be randomly distributed in various regions and that are the only source of atmospheric electricity and includes the effects of orography and electrical coupling along geomagnetic field lines in the ionosphere and magnetosphere. The model is used to calculate the global distribution of electric potential and current for model conductivities and assumed spatial distributions of thunderstorms. Results indicate that large positive electric potentials are generated over thunderstorms and penetrate to ionospheric heights and into the conjugate hemisphere along magnetic field lines. The perturbation of the calculated electric potential and current distributions during solar flares and subsequent Forbush decreases is discussed, and future measurements of atmospheric electrical parameters and modifications of the model which would improve the agreement between calculations and measurements are suggested.

Examining the Relationships Between Education, Social Networks and Democratic Support With ABM

NASA Technical Reports Server (NTRS)

Drucker, Nick; Campbell, Kenyth

2011-01-01

This paper introduces an agent-based model that explores the relationships between education, social networks, and support for democratic ideals. This study examines two factors thai affect democratic support, education, and social networks. Current theory concerning these two variables suggests that positive relationships exist between education and democratic support and between social networks and the spread of ideas. The model contains multiple variables of democratic support, two of which are evaluated through experimentation. The model allows individual entities within the system to make "decisions" about their democratic support independent of one another. The agent based approach also allows entities to utilize their social networks to spread ideas. Current theory supports experimentation results. In addion , these results show the model is capable of reproducing real world outcomes. This paper addresses the model creation process and the experimentation procedure, as well as future research avenues and potential shortcomings of the model

Basic priority rating model 2.0: current applications for priority setting in health promotion practice.

PubMed

Neiger, Brad L; Thackeray, Rosemary; Fagen, Michael C

2011-03-01

Priority setting is an important component of systematic planning in health promotion and also factors into the development of a comprehensive evaluation plan. The basic priority rating (BPR) model was introduced more than 50 years ago and includes criteria that should be considered in any priority setting approach (i.e., use of predetermined criteria, standardized comparisons, and a rubric that controls bias). Although the BPR model has provided basic direction in priority setting, it does not represent the broad array of data currently available to decision makers. Elements in the model also give more weight to the impact of communicable diseases compared with chronic diseases. For these reasons, several modifications are recommended to improve the BPR model and to better assist health promotion practitioners in the priority setting process. The authors also suggest a new name, BPR 2.0, to represent this revised model.

Uncertainty squared: Choosing among multiple input probability distributions and interpreting multiple output probability distributions in Monte Carlo climate risk models

NASA Astrophysics Data System (ADS)

Baer, P.; Mastrandrea, M.

2006-12-01

Simple probabilistic models which attempt to estimate likely transient temperature change from specified CO2 emissions scenarios must make assumptions about at least six uncertain aspects of the causal chain between emissions and temperature: current radiative forcing (including but not limited to aerosols), current land use emissions, carbon sinks, future non-CO2 forcing, ocean heat uptake, and climate sensitivity. Of these, multiple PDFs (probability density functions) have been published for the climate sensitivity, a couple for current forcing and ocean heat uptake, one for future non-CO2 forcing, and none for current land use emissions or carbon cycle uncertainty (which are interdependent). Different assumptions about these parameters, as well as different model structures, will lead to different estimates of likely temperature increase from the same emissions pathway. Thus policymakers will be faced with a range of temperature probability distributions for the same emissions scenarios, each described by a central tendency and spread. Because our conventional understanding of uncertainty and probability requires that a probabilistically defined variable of interest have only a single mean (or median, or modal) value and a well-defined spread, this "multidimensional" uncertainty defies straightforward utilization in policymaking. We suggest that there are no simple solutions to the questions raised. Crucially, we must dispel the notion that there is a "true" probability probabilities of this type are necessarily subjective, and reasonable people may disagree. Indeed, we suggest that what is at stake is precisely the question, what is it reasonable to believe, and to act as if we believe? As a preliminary suggestion, we demonstrate how the output of a simple probabilistic climate model might be evaluated regarding the reasonableness of the outputs it calculates with different input PDFs. We suggest further that where there is insufficient evidence to clearly favor one range of probabilistic projections over another, that the choice of results on which to base policy must necessarily involve ethical considerations, as they have inevitable consequences for the distribution of risk In particular, the choice to use a more "optimistic" PDF for climate sensitivity (or other components of the causal chain) leads to the allowance of higher emissions consistent with any specified goal for risk reduction, and thus leads to higher climate impacts, in exchange for lower mitigation costs.

Modelling potential changes in marine biogeochemistry due to large-scale offshore tidal energy extraction

NASA Astrophysics Data System (ADS)

van der Molen, Johan

2015-04-01

Tidal power generation through submerged turbine-type devices is in an advanced stage of testing, and large-scale applications are being planned in areas with high tidal current speeds. The potential impact of such large-scale applications on the hydrography can be investigated using hydrodynamical models. In addition, aspects of the potential impact on the marine ecosystem can be studied using biogeochemical models. In this study, the coupled hydrodynamics-biogeochemistry model GETM-ERSEM is used in a shelf-wide application to investigate the potential impact of large-scale tidal power generation in the Pentland Firth. A scenario representing the currently licensed power extraction suggested i) an average reduction in M2 tidal current velocities of several cm/s within the Pentland Firth, ii) changes in the residual circulation of several mm/s in the vicinity of the Pentland Firth, iii) an increase in M2 tidal amplitude of up to 1 cm to the west of the Pentland Firth, and iv) a reduction of several mm in M2 tidal amplitude along the east coast of the UK. A second scenario representing 10 times the currently licensed power extraction resulted in changes that were approximately 10 times as large. Simulations including the biogeochemistry model for these scenarios are currently in preparation, and first results will be presented at the the conference, aiming at impacts on primary production and benthic production.

Controls on the global distribution of contourite drifts: Insights from an eddy-resolving ocean model

NASA Astrophysics Data System (ADS)

Thran, Amanda C.; Dutkiewicz, Adriana; Spence, Paul; Müller, R. Dietmar

2018-05-01

Contourite drifts are anomalously high sediment accumulations that form due to reworking by bottom currents. Due to the lack of a comprehensive contourite database, the link between vigorous bottom water activity and drift occurrence has yet to be demonstrated on a global scale. Using an eddy-resolving ocean model and a new georeferenced database of 267 contourites, we show that the global distribution of modern contourite drifts strongly depends on the configuration of the world's most powerful bottom currents, many of which are associated with global meridional overturning circulation. Bathymetric obstacles frequently modify flow direction and intensity, imposing additional finer-scale control on drift occurrence. Mean bottom current speed over contourite-covered areas is only slightly higher (2.2 cm/s) than the rest of the global ocean (1.1 cm/s), falling below proposed thresholds deemed necessary to re-suspend and redistribute sediments (10-15 cm/s). However, currents fluctuate more frequently and intensely over areas with drifts, highlighting the role of intermittent, high-energy bottom current events in sediment erosion, transport, and subsequent drift accumulation. We identify eddies as a major driver of these bottom current fluctuations, and we find that simulated bottom eddy kinetic energy is over three times higher in contourite-covered areas in comparison to the rest of the ocean. Our work supports previous hypotheses which suggest that contourite deposition predominantly occurs due to repeated acute events as opposed to continuous reworking under average-intensity background flow conditions. This suggests that the contourite record should be interpreted in terms of a bottom current's susceptibility to experiencing periodic, high-speed current events. Our results also highlight the potential role of upper ocean dynamics in contourite sedimentation through its direct influence on deep eddy circulation.

The ionic bases of the action potential in isolated mouse cardiac Purkinje cell.

PubMed

Vaidyanathan, Ravi; O'Connell, Ryan P; Deo, Makarand; Milstein, Michelle L; Furspan, Philip; Herron, Todd J; Pandit, Sandeep V; Musa, Hassan; Berenfeld, Omer; Jalife, José; Anumonwo, Justus M B

2013-01-01

Collecting electrophysiological and molecular data from the murine conduction system presents technical challenges. Thus, only little advantage has been taken of numerous genetically engineered murine models to study excitation through the cardiac conduction system of the mouse. To develop an approach for isolating murine cardiac Purkinje cells (PCs), to characterize major ionic currents and to use the data to simulate action potentials (APs) recorded from PCs. Light microscopy was used to isolate and identify PCs from apical and septal cells. Current and voltage clamp techniques were used to record APs and whole cell currents. We then simulated a PC AP on the basis of our experimental data. APs recorded from PCs were significantly longer than those recorded from ventricular cells. The prominent plateau phase of the PC AP was very negative (≈-40 mV). Spontaneous activity was observed only in PCs. The inward rectifier current demonstrated no significant differences compared to ventricular myocytes (VMs). However, sodium current density was larger, and the voltage-gated potassium current density was significantly less in PCs compared with myocytes. T-type Ca(2+) currents (I(Ca,T)) were present in PCs but not VMs. Computer simulations suggest that I(Ca,T) and cytosolic calcium diffusion significantly modulate AP profile recorded in PCs, as compared to VMs. Our study provides the first comprehensive ionic profile of murine PCs. The data show unique features of PC ionic mechanisms that govern its excitation process. Experimental data and numerical modeling results suggest that a smaller voltage-gated potassium current and the presence of I(Ca,T) are important determinants of the longer and relatively negative plateau phase of the APs. Copyright © 2013 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

General Education Courses at the University of Botswana: Application of the Theory of Reasoned Action in Measuring Course Outcomes

ERIC Educational Resources Information Center

Garg, Deepti; Garg, Ajay K.

2007-01-01

This study applied the Theory of Reasoned Action and the Technology Acceptance Model to measure outcomes of general education courses (GECs) under the University of Botswana Computer and Information Skills (CIS) program. An exploratory model was validated for responses from 298 students. The results suggest that resources currently committed to…

Using Incremental Rehearsal to Increase Fluency of Single-Digit Multiplication Facts with Children Identified as Learning Disabled in Mathematics Computation

ERIC Educational Resources Information Center

Burns, Matthew K.

2005-01-01

Previous research suggested that Incremental Rehearsal (IR; Tucker, 1989) led to better retention than other drill practices models. However, little research exists in the literature regarding drill models for mathematics and no studies were found that used IR to practice multiplication facts. Therefore, the current study used IR as an…

Reductions in Experienced Control and Depression in Psychiatric Inpatients: A Test of the Learned Helplessness Model

ERIC Educational Resources Information Center

Dinning, W. David; Evans, Ronald G.

1978-01-01

In critically reviewing learned helplessness literature, P. H. Blaney (1977) has noted that most of the current support for this model rests on studies that induce or reduce helplessness in college student Ss. This research, employing a psychiatric population, addressed two issues Blaney suggested as in need of clarification: (1) the role of…

Cultivating Innovative and Entrepreneurial Talent in the Higher Vocational Automotive Major with the "On-Board Educational Factory" Model

ERIC Educational Resources Information Center

Wu, Zhuang-Wen; Zhu, Liang-Rong

2017-01-01

In this paper, we investigate the steps necessary to initiate reform in professional education. First, we analyze the advantages and disadvantages of the unified theory and practice model of education currently adopted in mainland China. Next, we suggest a talent cultivation strategy that prioritizes students and views industrial (factory)…

The Fowler-Nordheim behavior and mechanism of photo-sensitive field from SnS{sub 2} nanosheets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suryawanshi, Sachin R.; Chaudhari, Nilima S.; Warule, Sambhaji S.

2015-06-24

Here in, we report photo-sensitive field emission measurements of SnS{sub 2} nanosheets at base pressure of ∼1×10{sup −8} mbar are reported. The nonlinear Fowler-Nordheim (F-N) plot is elucidate according to a (F-N) model of calculation based on shift in a saturation of conduction band current density after light illumination and prevalence of valence band current density at high electric field values. The model of calculation suggests that the slope variation before and after visible light illumination of the F-N plot, in the high-field and low-field regions, does not depend on the magnitude of saturation but also depend on charge carriermore » (electron) concentration get increased in conduction band. The F-N model of calculation is important for the fundamental understanding of the photo-sensitive field emission mechanism of semiconducting SnS{sub 2}. The replicate F-N plots exhibit similar features to those observed experimentally. The model calculation suggests that the nonlinearity of the F-N plot is a characteristic of the photo-enhanced energy band structure of the photo-sensitive semiconductor material.« less

Improving the representation of Arctic photosynthesis in Earth system models

NASA Astrophysics Data System (ADS)

Rogers, A.; Serbin, S.; Ely, K.; Sloan, V. L.; Wyatt, R. A.; Kubien, D. S.; Ali, A. A.; Xu, C.; Wullschleger, S. D.

2015-12-01

The primary goal of Earth System Models (ESMs) is to improve understanding and projection of future global change. In order to do this they must accurately represent the carbon fluxes associated with the terrestrial carbon cycle. Although Arctic carbon fluxes are small - relative to global carbon fluxes - uncertainty is large. As part of a multidisciplinary project to improve the representation of the Arctic in ESMs (Next Generation Ecosystem Experiments - Arctic) we are examining the photosynthetic parameterization of the Arctic plant functional type (PFT) in ESMs. Photosynthetic CO2 uptake is well described by the Farquhar, von Caemmerer and Berry (FvCB) model of photosynthesis. Most ESMs use a derivation of the FvCB model to calculate gross primary productivity. Two key parameters required by the FvCB model are an estimate of the maximum rate of carboxylation by the enzyme Rubisco (Vc,max) and the maximum rate of electron transport (Jmax). In ESMs the parameter Vc,max is usually fixed for a given PFT. Only four ESMs currently have an explicit Arctic PFT and the data used to derive Vc,max for the Arctic PFT in these models relies on small data sets and unjustified assumptions. We examined the derivation of Vc,max and Jmax in current Arctic PFTs and estimated Vc,max and Jmax for 7 species representing both dominant vegetation and key Arctic PFTs growing on the Barrow Environmental Observatory, Barrow, AK. The values of Vc,max currently used to represent Arctic PFTs in ESMs are 70% lower than the values we measured in these species. Examination of the derivation of Vc,max in ESMs identified that the cause of the relatively low Vc,max value was the result of underestimating both the leaf N content and the investment of that N in Rubisco. Contemporary temperature response functions for Vc,max also appear to underestimate Vc,max at low temperature. ESMs typically use a single multiplier (JVratio) to convert Vc,max to Jmax for all PFTs. We found that the JVratio of Arctic plants is higher than current estimates suggesting that the Arctic PFT will be more responsive to rising carbon dioxide than currently projected. Our data suggest that the Arctic tundra has a much greater capacity for CO2 uptake, particularly at low temperature, and will be more CO2 responsive than is currently represented in ESMs.

Photospheric Current Spikes as Possible Predictors of Flares

NASA Technical Reports Server (NTRS)

Goodman, Michael L.; Kwan, Chiman; Ayhan, Bulent; Shang, Eric L.

2016-01-01

Flares involve generation of the largest current densities in the solar atmosphere. This suggests the hypothesis that prior to a large (M,X) flare there are related time dependent changes in the photospheric current distribution, and hence in the resistive heating rate in neutral line regions (NLRs). If this is true, these changes might be useful predictors of flares. Preliminary evidence supporting this hypothesis is presented. Results from a data driven, near photospheric, 3D magnetohydrodynamic type model suggest the model might be useful for predicting M and X flares several hours to several days in advance. The model takes as input the photospheric magnetic field observed by the Helioseismic and Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO) satellite. The model computes quantities in every active region (AR) pixel for 14 ARs, with spurious Doppler periods due to SDO orbital motion filtered out of the time series of the magnetic field for each pixel. Spikes in the NLR resistive heating rate Q, appearing as increases by orders of magnitude above background values in the time series of Q are found to occur, and appear to be correlated with the occurrence of M or X flares a few hours to a few days later. The subset of spikes analyzed at the pixel level are found to occur on HMI and granulation scales of 1 arcsec and 12 minutes. Spikes are found in NLRs with and without M or X flares, and outside as well as inside NLRs, but the largest spikes are localized in the NLRs of ARs with M or X flares, and associated with horizontal magnetic field strengths approximately several hG, and vertical magnetic field strengths several orders of magnitude smaller. The spikes may be signatures of horizontal current sheets associated with emerging magnetic flux.

Generation and preservation of the slow underlying membrane potential oscillation in model bursting neurons.

PubMed

Franklin, Clarence C; Ball, John M; Schulz, David J; Nair, Satish S

2010-09-01

The underlying membrane potential oscillation of both forced and endogenous slow-wave bursting cells affects the number of spikes per burst, which in turn affects outputs downstream. We use a biophysical model of a class of slow-wave bursting cells with six active currents to investigate and generalize correlations among maximal current conductances that might generate and preserve its underlying oscillation. We propose three phases for the underlying oscillation for this class of cells: generation, maintenance, and termination and suggest that different current modules coregulate to preserve the characteristics of each phase. Coregulation of I(Burst) and I(A) currents within distinct boundaries maintains the dynamics during the generation phase. Similarly, coregulation of I(CaT) and I(Kd) maintains the peak and duration of the underlying oscillation, whereas the calcium-activated I(KCa) ensures appropriate termination of the oscillation and adjusts the duration independent of peak.

Co-occurring Substance Abuse and Mental Health Problems among Homeless Persons: Suggestions for Research and Practice.

PubMed

Polcin, Douglas L

Communities throughout the U.S. are struggling to find solutions for serious and persistent homelessness. Alcohol and drug problems can be causes and consequences of homelessness, as well as co-occurring problems that complicate efforts to succeed in finding stable housing. Two prominent service models exist, one known as "Housing First" takes a harm reduction approach and the other known as the "linear" model typically supports a goal of abstinence from alcohol and drugs. Despite their popularity, the research supporting these models suffers from methodological problems and inconsistent findings. One purpose of this paper is to describe systematic reviews of the homelessness services literature, which illustrate weaknesses in research designs and inconsistent conclusions about the effectiveness of current models. Problems among some of the seminal studies on homelessness include poorly defined inclusion and exclusion criteria, inadequate measures of alcohol and drug use, unspecified or poorly implemented comparison conditions, and lack of procedures documenting adherence to service models. Several recent papers have suggested broader based approaches for homeless services that integrate alternatives and respond better to consumer needs. Practical considerations for implementing a broader system of services are described and peer managed recovery homes are presented as examples of services that address some of the gaps in current approaches. Three issues are identified that need more attention from researchers: 1) improving upon the methodological limitations in current studies, 2) assessing the impact of broader based, integrated services on outcome, and 3) assessing approaches to the service needs of homeless persons involved in the criminal justice system.

Co-occurring substance abuse and mental health problems among homeless persons: Suggestions for research and practice

PubMed Central

Polcin, Douglas L.

2016-01-01

Abstract Communities throughout the U.S. are struggling to find solutions for serious and persistent homelessness. Alcohol and drug problems can be causes and consequences of homelessness, as well as co-occurring problems that complicate efforts to succeed in finding stable housing. Two prominent service models exist, one known as “Housing First” takes a harm reduction approach and the other known as the “linear” model typically supports a goal of abstinence from alcohol and drugs. Despite their popularity, the research supporting these models suffers from methodological problems and inconsistent findings. One purpose of this paper is to describe systematic reviews of the homelessness services literature, which illustrate weaknesses in research designs and inconsistent conclusions about the effectiveness of current models. Problems among some of the seminal studies on homelessness include poorly defined inclusion and exclusion criteria, inadequate measures of alcohol and drug use, unspecified or poorly implemented comparison conditions, and lack of procedures documenting adherence to service models. Several recent papers have suggested broader based approaches for homeless services that integrate alternatives and respond better to consumer needs. Practical considerations for implementing a broader system of services are described and peer-managed recovery homes are presented as examples of services that address some of the gaps in current approaches. Three issues are identified that need more attention from researchers: (1) improving upon the methodological limitations in current studies, (2) assessing the impact of broader based, integrated services on outcome, and (3) assessing approaches to the service needs of homeless persons involved in the criminal justice system. PMID:27092027

Two-Dimensional Analysis of Conical Pulsed Inductive Plasma Thruster Performance

NASA Technical Reports Server (NTRS)

Hallock, A. K.; Polzin, K. A.; Emsellem, G. D.

2011-01-01

A model of the maximum achievable exhaust velocity of a conical theta pinch pulsed inductive thruster is presented. A semi-empirical formula relating coil inductance to both axial and radial current sheet location is developed and incorporated into a circuit model coupled to a momentum equation to evaluate the effect of coil geometry on the axial directed kinetic energy of the exhaust. Inductance measurements as a function of the axial and radial displacement of simulated current sheets from four coils of different geometries are t to a two-dimensional expression to allow the calculation of the Lorentz force at any relevant averaged current sheet location. This relation for two-dimensional inductance, along with an estimate of the maximum possible change in gas-dynamic pressure as the current sheet accelerates into downstream propellant, enables the expansion of a one-dimensional circuit model to two dimensions. The results of this two-dimensional model indicate that radial current sheet motion acts to rapidly decouple the current sheet from the driving coil, leading to losses in axial kinetic energy 10-50 times larger than estimations of the maximum available energy in the compressed propellant. The decreased available energy in the compressed propellant as compared to that of other inductive plasma propulsion concepts suggests that a recovery in the directed axial kinetic energy of the exhaust is unlikely, and that radial compression of the current sheet leads to a loss in exhaust velocity for the operating conditions considered here.

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model.

PubMed

Limpitikul, Worawan B; Viswanathan, Meera C; O'Rourke, Brian; Yue, David T; Cammarato, Anthony

2018-04-21

Dysregulation of L-type Ca 2+ channels (LTCCs) underlies numerous cardiac pathologies. Understanding their modulation with high fidelity relies on investigating LTCCs in their native environment with intact interacting proteins. Such studies benefit from genetic manipulation of endogenous channels in cardiomyocytes, which often proves cumbersome in mammalian models. Drosophila melanogaster, however, offers a potentially efficient alternative as it possesses a relatively simple heart, is genetically pliable, and expresses well-conserved genes. Fluorescence in situ hybridization confirmed an abundance of Ca-α1D and Ca-α1T mRNA in fly myocardium, which encode subunits that specify hetero-oligomeric channels homologous to mammalian LTCCs and T-type Ca 2+ channels, respectively. Cardiac-specific knockdown of Ca-α1D via interfering RNA abolished cardiac contraction, suggesting Ca-α1D (i.e. A1D) represents the primary functioning Ca 2+ channel in Drosophila hearts. Moreover, we successfully isolated viable single cardiomyocytes and recorded Ca 2+ currents via patch clamping, a feat never before accomplished with the fly model. The profile of Ca 2+ currents recorded in individual cells when Ca 2+ channels were hypomorphic, absent, or under selective LTCC blockage by nifedipine, additionally confirmed the predominance of A1D current across all activation voltages. T-type current, activated at more negative voltages, was also detected. Lastly, A1D channels displayed Ca 2+ -dependent inactivation, a critical negative feedback mechanism of LTCCs, and the current through them was augmented by forskolin, an activator of the protein kinase A pathway. In sum, the Drosophila heart possesses a conserved compendium of Ca 2+ channels, suggesting that the fly may serve as a robust and effective platform for studying cardiac channelopathies. Copyright © 2018 Elsevier Ltd. All rights reserved.

Bottom-boundary-layer measurements on the continental shelf off the Ebro River, Spain

USGS Publications Warehouse

Cacchione, D.A.; Drake, D.E.; Losada, M.A.; Medina, R.

1990-01-01

Measurements of currents, waves and light transmission obtained with an instrumented bottom tripod (GEOPROBE) were used in conjunction with a theoretical bottom-boundary-layer model for waves and currents to investigate sediment transport on the continental shelf south of the Ebro River Delta, Spain. The current data show that over a 48-day period during the fall of 1984, the average transport at 1 m above the seabed was alongshelf and slightly offshore toward the south-southwest at about 2 cm/s. A weak storm passed through the region during this period and caused elevated wave and current speeds near the bed. The bottom-boundary-layer model predicted correspondingly higher combined wave and current bottom shear velocities at this time, but the GEOPROBE optical data indicate that little to no resuspension occurred. This result suggests that the fine-grained bottom sediment, which has a clay component of 80%, behaves cohesively and is more difficult to resuspend than noncohesive materials of similar size. Model computations also indicate that noncohesive very fine sand in shallow water (20 m deep) was resuspended and transported mainly as bedload during this storm. Fine-grained materials in shallow water that are resuspended and transported as suspended load into deeper water probably account for the slight increase in sediment concentration at the GEOPROBE sensors during the waning stages of the storm. The bottom-boundary-layer data suggest that the belt of fine-grained bottom sediment that extends along the shelf toward the southwest is deposited during prolonged periods of low energy and southwestward bottom flow. This pattern is augmented by enhanced resuspension and transport toward the southwest during storms. ?? 1990.

Bimodal Action of Protons on ATP Currents of Rat PC12 Cells

PubMed Central

Skorinkin, Andrei; Nistri, Andrea; Giniatullin, Rashid

2003-01-01

The mode of action of extracellular protons on ATP-gated P2X2 receptors remains controversial as either enhancement or depression of ATP-mediated currents has been reported. By investigating, at different pH, the electrophysiological effect of ATP on P2X2 receptors and complementing it with receptor modelling, the present study suggests a unified mechanism for both potentiation and inactivation of ATP receptors by protons. Our experiments on patch-clamped PC12 cells showed that, on the same cell, mild acidification potentiated currents induced by low ATP concentrations (<0.1 mM) and attenuated responses to high ATP concentrations (>1 mM) with emergence of current fading and rebound. To clarify the nature of the ATP/H+ interaction, we used the Ding and Sachs's “loop” receptor model which best describes the behavior of such receptors with two open states linked via one inactivated state. No effects by protons could be ascribed to H+-mediated open channel block. However, by assuming that protons facilitated binding of ATP to resting as well as open receptors, the model could closely replicate H+-induced potentiation of currents evoked by low ATP doses plus fading and rebound induced by high ATP doses. The latter phenomenon was due to receptor transition to the inactive state. The present data suggest that the high concentration of protons released with ATP (and catecholamines) from secretory vesicles may allow a dual action of H+ on P2X2 receptors. This condition might also occur on P2X2 receptors of central neurons exposed to low pH during ischemia. PMID:12810852

Enhanced hexadecane degradation and low biomass production by Aspergillus niger exposed to an electric current in a model system.

PubMed

Velasco-Alvarez, Nancy; González, Ignacio; Damian-Matsumura, Pablo; Gutiérrez-Rojas, Mariano

2011-01-01

The effects of an electric current on growth and hexadecane (HXD) degradation by Aspergillus niger growth were determined. A 450-mL electrochemical cell with titanium ruthenium-oxide coated electrodes and packed with 15 g of perlite (inert biomass support) was inoculated with A. niger (2.0×10(7) spores (g of dry inert support)(-1)) and incubated for 12 days (30 °C; constant ventilation). 4.5 days after starting culture a current of 0.42 mA cm(-2) was applied for 24h. The current reduced (52±11%) growth of the culture as compared to that of a culture not exposed to current. However, HXD degradation was 96±1.4% after 8 days whereas it was 81±1.2% after 12 days in control cultures. Carbon balances of cultures not exposed to current suggested an assimilative metabolism, but a non-assimilative metabolism when the current was applied. This change can be related to an increase in total ATP content. The study contributes to the knowledge on the effects of current on the mycelial growth phase of A. niger, and suggests the possibility of manipulating the metabolism of this organism with electric current. Copyright © 2010 Elsevier Ltd. All rights reserved.

Variability in modeled cloud feedback tied to differences in the climatological spatial pattern of clouds

NASA Astrophysics Data System (ADS)

Siler, Nicholas; Po-Chedley, Stephen; Bretherton, Christopher S.

2018-02-01

Despite the increasing sophistication of climate models, the amount of surface warming expected from a doubling of atmospheric CO_2 (equilibrium climate sensitivity) remains stubbornly uncertain, in part because of differences in how models simulate the change in global albedo due to clouds (the shortwave cloud feedback). Here, model differences in the shortwave cloud feedback are found to be closely related to the spatial pattern of the cloud contribution to albedo (α) in simulations of the current climate: high-feedback models exhibit lower (higher) α in regions of warm (cool) sea-surface temperatures, and therefore predict a larger reduction in global-mean α as temperatures rise and warm regions expand. The spatial pattern of α is found to be strongly predictive (r=0.84) of a model's global cloud feedback, with satellite observations indicating a most-likely value of 0.58± 0.31 Wm^{-2} K^{-1} (90% confidence). This estimate is higher than the model-average cloud feedback of 0.43 Wm^{-2} K^{-1}, with half the range of uncertainty. The observational constraint on climate sensitivity is weaker but still significant, suggesting a likely value of 3.68 ± 1.30 K (90% confidence), which also favors the upper range of model estimates. These results suggest that uncertainty in model estimates of the global cloud feedback may be substantially reduced by ensuring a realistic distribution of clouds between regions of warm and cool SSTs in simulations of the current climate.

Factor Structure of the Psychopathic Personality Inventory (PPI): Findings from a Large Incarcerated Sample

PubMed Central

Neumann, Craig S.; Malterer, Melanie B.; Newman, Joseph P.

2010-01-01

Recent exploratory factor analysis (EFA) of the Psychopathic Personality Inventory (PPI; Lilienfeld, 1990) with a community sample suggested that the PPI subscales may be comprised of two higher-order factors (Benning et al., 2003). However, little research has examined the PPI structure in offenders. The current study attempted to replicate the Benning et al. two-factor solution using a large (N=1224) incarcerated male sample. Confirmatory factor analysis (CFA) of this model with the full sample resulted in poor model fit. Next, to identify a factor solution that would summarize the offender data, EFA was conducted using a split-half of the total sample, followed by an attempt to replicate the EFA solution via CFA with the other split-half sample. Using the recommendations of Prooijen and van der Kloot (2001) for recovering EFA solutions, model fit results provided some evidence that the EFA solution could be recovered via CFA. However, this model involved extensive cross-loadings of the subscales across three factors, suggesting item overlap across PPI subscales. In sum, the two-factor solution reported by Benning et al. (2003) was not a viable model for the current sample of offenders, and additional research is needed to elucidate the latent structure of the PPI. PMID:18557694

Risk Management and Physical Modelling for Mountainous Natural Hazards

NASA Astrophysics Data System (ADS)

Lehning, Michael; Wilhelm, Christian

Population growth and climate change cause rapid changes in mountainous regions resulting in increased risks of floods, avalanches, debris flows and other natural hazards. Xevents are of particular concern, since attempts to protect against them result in exponentially growing costs. In this contribution, we suggest an integral risk management approach to dealing with natural hazards that occur in mountainous areas. Using the example of a mountain pass road, which can be protected from the danger of an avalanche by engineering (galleries) and/or organisational (road closure) measures, we show the advantage of an optimal combination of both versus the traditional approach, which is to rely solely on engineering structures. Organisational measures become especially important for Xevents because engineering structures cannot be designed for those events. However, organisational measures need a reliable and objective forecast of the hazard. Therefore, we further suggest that such forecasts should be developed using physical numerical modelling. We present the status of current approaches to using physical modelling to predict snow cover stability for avalanche warnings and peak runoff from mountain catchments for flood warnings. While detailed physical models can already predict peak runoff reliably, they are only used to support avalanche warnings. With increased process knowledge and computer power, current developments should lead to a enhanced role for detailed physical models in natural mountain hazard prediction.

Comparing mechanistic and empirical approaches to modeling the thermal niche of almond

NASA Astrophysics Data System (ADS)

Parker, Lauren E.; Abatzoglou, John T.

2017-09-01

Delineating locations that are thermally viable for cultivating high-value crops can help to guide land use planning, agronomics, and water management. Three modeling approaches were used to identify the potential distribution and key thermal constraints on on almond cultivation across the southwestern United States (US), including two empirical species distribution models (SDMs)—one using commonly used bioclimatic variables (traditional SDM) and the other using more physiologically relevant climate variables (nontraditional SDM)—and a mechanistic model (MM) developed using published thermal limitations from field studies. While models showed comparable results over the majority of the domain, including over existing croplands with high almond density, the MM suggested the greatest potential for the geographic expansion of almond cultivation, with frost susceptibility and insufficient heat accumulation being the primary thermal constraints in the southwestern US. The traditional SDM over-predicted almond suitability in locations shown by the MM to be limited by frost, whereas the nontraditional SDM showed greater agreement with the MM in these locations, indicating that incorporating physiologically relevant variables in SDMs can improve predictions. Finally, opportunities for geographic expansion of almond cultivation under current climatic conditions in the region may be limited, suggesting that increasing production may rely on agronomical advances and densifying current almond plantations in existing locations.

A framework for the management of intellectual capital in the health care industry.

PubMed

Grantham, C E; Nichols, L D; Schonberner, M

1997-01-01

This article proposes a new theoretical model for the effective management of intellectual capital in the health care industry. The evolution of knowledge-based resources as a value-adding characteristic of service industries coupled with mounting environmental pressures on health care necessitates the extension of current models of intellectual capital. Our theoretical model contains an expanded context linking its development to organizational learning theory and extends current theory by proposing a six-term archetype of organizational functioning built on flows of information. Further, our proposal offers a hierarchical dimension to intellectual capital and a method of scientific visualization for the measurement of intellectual capital. In conclusion, we offer some practical suggestions for future development, both for researchers and managers.

Electromagnetic Model Of A Lightning Dart Leader In The Earth Atmosphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordeev, A. V.; Losseva, T. V.

2006-01-15

The fundamentally new approach to the lightning step and dart leaders structure model is suggested, which shows a possibility of the drift propagation for the electrons in a plasma channel. Appearance of the strong Hall electric field in the current channel by the account of the magnetic field can result in the generation of the relativistic drifting electrons to be held in the channel due to the magnetic self-insulation effect. The range of the measured x-ray emission from the lightning channel 30-250 keV, which corresponds to the measured current value 4-11 kA, is in a reasonably good agreement with themore » estimates made in the framework of presented model.« less

In silico simulations of experimental protocols for cardiac modeling.

PubMed

Carro, Jesus; Rodriguez, Jose Felix; Pueyo, Esther

2014-01-01

A mathematical model of the AP involves the sum of different transmembrane ionic currents and the balance of intracellular ionic concentrations. To each ionic current corresponds an equation involving several effects. There are a number of model parameters that must be identified using specific experimental protocols in which the effects are considered as independent. However, when the model complexity grows, the interaction between effects becomes increasingly important. Therefore, model parameters identified considering the different effects as independent might be misleading. In this work, a novel methodology consisting in performing in silico simulations of the experimental protocol and then comparing experimental and simulated outcomes is proposed for parameter model identification and validation. The potential of the methodology is demonstrated by validating voltage-dependent L-type calcium current (ICaL) inactivation in recently proposed human ventricular AP models with different formulations. Our results show large differences between ICaL inactivation as calculated from the model equation and ICaL inactivation from the in silico simulations due to the interaction between effects and/or to the experimental protocol. Our results suggest that, when proposing any new model formulation, consistency between such formulation and the corresponding experimental data that is aimed at being reproduced needs to be first verified considering all involved factors.

In defense of genuine ignorance: supporting vitality and relevance in graduate curricula.

PubMed

Goren, S; Peter, L; Fischer, S

1992-01-01

Genuine ignorance, defined by John Dewey as curiosity and openmindedness in opposition to repetition of catch phrases and familiar propositions, is nurtured in graduate nursing curricula in which the educational process is congruent with course content. Preparation for advanced practice in the mental health environment of the foreseeable future required abandonment of the familiar medical model in favor of conceptual models consistent with current thinking in psychiatric nursing and exposure to current problems (homelessness, family violence, AIDS) and current problem solving strategies (brief treatment, family preservation). Involvement in practice-based research and operationalizing new perspectives on familiar clinical problems, are suggested as strategies for developing the advanced practitioner. Two of the authors, former graduate students, describe the impact of changed perspectives and research activity on their own practice.

Influence of San Gabriel submarine canyon on narrow-shelf sediment dynamics, southern California

USGS Publications Warehouse

Karl, Herman A.

1980-01-01

A conceptual model attributes the PTC to modification of shelf circulation patterns by San Gabriel Canyon. Surface waves diverge over the canyon head resulting in differential wave set up at the shore face. This forces back turbid nearshore water for a distance of a few kilometers toward the canyon. At some point on the shelf, seaward nearshore flow overlaps offshore currents generated or modified by internal waves focused onto the shelf by the canyon and/or turbulent eddies produced by flow separation in currents moving across the canyon axis. At times, these subtle processes overprint tidal and wind-driven currents and thereby create the PTC. The model suggests that canyons heading several kilometers from shore can have a regulatory effect on narrow-shelf sediment dynamics.

High sensitivity of spontaneous spike frequency to sodium leak current in a Lymnaea pacemaker neuron.

PubMed

Lu, T Z; Kostelecki, W; Sun, C L F; Dong, N; Pérez Velázquez, J L; Feng, Z-P

2016-12-01

The spontaneous rhythmic firing of action potentials in pacemaker neurons depends on the biophysical properties of voltage-gated ion channels and background leak currents. The background leak current includes a large K + and a small Na + component. We previously reported that a Na + -leak current via U-type channels is required to generate spontaneous action potential firing in the identified respiratory pacemaker neuron, RPeD1, in the freshwater pond snail Lymnaea stagnalis. We further investigated the functional significance of the background Na + current in rhythmic spiking of RPeD1 neurons. Whole-cell patch-clamp recording and computational modeling approaches were carried out in isolated RPeD1 neurons. The whole-cell current of the major ion channel components in RPeD1 neurons were characterized, and a conductance-based computational model of the rhythmic pacemaker activity was simulated with the experimental measurements. We found that the spiking rate is more sensitive to changes in the Na + leak current as compared to the K + leak current, suggesting a robust function of Na + leak current in regulating spontaneous neuronal firing activity. Our study provides new insight into our current understanding of the role of Na + leak current in intrinsic properties of pacemaker neurons. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Shipborne LF-VLF oceanic lightning observations and modeling

NASA Astrophysics Data System (ADS)

Zoghzoghy, F. G.; Cohen, M. B.; Said, R. K.; Lehtinen, N. G.; Inan, U. S.

2015-10-01

Approximately 90% of natural lightning occurs over land, but recent observations, using Global Lightning Detection (GLD360) geolocation peak current estimates and satellite optical data, suggested that cloud-to-ground flashes are on average stronger over the ocean. We present initial statistics from a novel experiment using a Low Frequency (LF) magnetic field receiver system installed aboard the National Oceanic Atmospheric Agency (NOAA) Ronald W. Brown research vessel that allowed the detection of impulsive radio emissions from deep-oceanic discharges at short distances. Thousands of LF waveforms were recorded, facilitating the comparison of oceanic waveforms to their land counterparts. A computationally efficient electromagnetic radiation model that accounts for propagation over lossy and curved ground is constructed and compared with previously published models. We include the effects of Earth curvature on LF ground wave propagation and quantify the effects of channel-base current risetime, channel-base current falltime, and return stroke speed on the radiated LF waveforms observed at a given distance. We compare simulation results to data and conclude that previously reported larger GLD360 peak current estimates over the ocean are unlikely to fully result from differences in channel-base current risetime, falltime, or return stroke speed between ocean and land flashes.

From neuro-functional to neuro-computational models. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

NASA Astrophysics Data System (ADS)

Briesemeister, Benny B.

2015-06-01

Historically, there has been a strong opposition between psychological theories of human emotion that suggest a limited number of distinct functional categories, such as anger, fear, happiness and so forth (e.g. [1]), and theories that suggest processing along affective dimensions, such as valence and arousal (e.g. [2]). Only few current models acknowledge that both of these perspectives seem to be legitimate [3], and at their core, even fewer models connect these insights with knowledge about neurophysiology [4]. In this regard, the Quartet Theory of Human Emotions (QTHE) [5] makes a very important and useful contribution to the field of emotion research - but in my opinion, there is still at least one more step to go.

Assessing allometric models to predict vegetative growth of mango (Mangifera indica; Anacardiaceae) at the current-year branch scale.

PubMed

Normand, Frédéric; Lauri, Pierre-Éric

2012-03-01

Accurate and reliable predictive models are necessary to estimate nondestructively key variables for plant growth studies such as leaf area and leaf, stem, and total biomass. Predictive models are lacking at the current-year branch scale despite the importance of this scale in plant science. We calibrated allometric models to estimate leaf area and stem and branch (leaves + stem) mass of current-year branches, i.e., branches several months old studied at the end of the vegetative growth season, of four mango cultivars on the basis of their basal cross-sectional area. The effects of year, site, and cultivar were tested. Models were validated with independent data and prediction accuracy was evaluated with the appropriate statistics. Models revealed a positive allometry between dependent and independent variables, whose y-intercept but not the slope, was affected by the cultivar. The effects of year and site were negligible. For each branch characteristic, cultivar-specific models were more accurate than common models built with pooled data from the four cultivars. Prediction quality was satisfactory but with data dispersion around the models, particularly for large values. Leaf area and stem and branch mass of mango current-year branches could be satisfactorily estimated on the basis of branch basal cross-sectional area with cultivar-specific allometric models. The results suggested that, in addition to the heteroscedastic behavior of the variables studied, model accuracy was probably related to the functional plasticity of branches in relation to the light environment and/or to the number of growth units composing the branches.

Electrical stimulation of gut motility guided by an in silico model

NASA Astrophysics Data System (ADS)

Barth, Bradley B.; Henriquez, Craig S.; Grill, Warren M.; Shen, Xiling

2017-12-01

Objective. Neuromodulation of the central and peripheral nervous systems is becoming increasingly important for treating a diverse set of diseases—ranging from Parkinson’s Disease and epilepsy to chronic pain. However, neuromodulation of the gastrointestinal (GI) tract has achieved relatively limited success in treating functional GI disorders, which affect a significant population, because the effects of stimulation on the enteric nervous system (ENS) and gut motility are not well understood. Here we develop an integrated neuromechanical model of the ENS and assess neurostimulation strategies for enhancing gut motility, validated by in vivo experiments. Approach. The computational model included a network of enteric neurons, smooth muscle fibers, and interstitial cells of Cajal, which regulated propulsion of a virtual pellet in a model of gut motility. Main results. Simulated extracellular stimulation of ENS-mediated motility revealed that sinusoidal current at 0.5 Hz was more effective at increasing intrinsic peristalsis and reducing colon transit time than conventional higher frequency rectangular current pulses, as commonly used for neuromodulation therapy. Further analysis of the model revealed that the 0.5 Hz sinusoidal currents were more effective at modulating the pacemaker frequency of interstitial cells of Cajal. To test the predictions of the model, we conducted in vivo electrical stimulation of the distal colon while measuring bead propulsion in awake rats. Experimental results confirmed that 0.5 Hz sinusoidal currents were more effective than higher frequency pulses at enhancing gut motility. Significance. This work demonstrates an in silico GI neuromuscular model to enable GI neuromodulation parameter optimization and suggests that low frequency sinusoidal currents may improve the efficacy of GI pacing.

Rectifying the Optical-Field-Induced Current in Dielectrics: Petahertz Diode.

PubMed

Lee, J D; Yun, Won Seok; Park, Noejung

2016-02-05

Investigating a theoretical model of the optical-field-induced current in dielectrics driven by strong few-cycle laser pulses, we propose an asymmetric conducting of the current by forming a heterojunction made of two distinct dielectrics with a low hole mass (m_{h}^{*}≪m_{e}^{*}) and low electron mass (m_{e}^{*}≪m_{h}^{*}), respectively. This proposition introduces the novel concept of a petahertz (10^{15}  Hz) diode to rectify the current in the petahertz domain, which should be a key ingredient for the electric signal manipulation of future light-wave electronics. Further, we suggest the candidate dielectrics for the heterojunction.

Space Plasma Studies by In-Situ and Remote Measurements

DTIC Science & Technology

1998-06-09

Martian topography and "geology". We also report on their role in the deflection of the solar wind and the development of the detached Martian bow...regions onboard POLAR spacecraft (Chen et al., 1997) supports the model inferences. INNER MAGNETOSPHERE CURRENTS AND ITS ROLE IN MAGNETOSPHERE DYNAMICS...taspd.npi.msu.su . The role of inner magnetosphere currents in the magnetosphere dynamics is analyzed. It is suggested that when plasma bulk velocity is

A new, but old business model for family physicians: cash.

PubMed

Weber, J Michael

2013-01-01

The following study is an exploratory investigation into the opportunity identification, opportunity analysis, and strategic implications of implementing a cash-only family physician practice. The current market dynamics (i.e., increasing insurance premiums, decreasing benefits, more regulations and paperwork, and cuts in federal and state programs) suggest that there is sufficient motivation for these practitioners to change their current business model. In-depth interviews were conducted with office managers and physicians of family physician practices. The results highlighted a variety of issues, including barriers to change, strategy issues, and opportunities/benefits. The implications include theory applications, strategic marketing applications, and managerial decision-making.

Effect of surface bilayer charges on the magnetic field around ionic channels

NASA Astrophysics Data System (ADS)

Gomes Soares, Marília Amável; Cortez, Celia Martins; Oliveira Cruz, Frederico Alan de; Silva, Dilson

2017-01-01

In this work, we present a physic-mathematical model for representing the ion transport through membrane channels, in special Na+ and K+-channels, and discuss the influence of surface bilayer charges on the magnetic field behavior around the ionic current. The model was composed of a set of equations, including: a nonlinear differential Poisson-Boltzmann equation which usually allows to estimate the surface potentials and electric potential profile across membrane; equations for the ionic flux through channel and the ionic current density based on Armstrong's model for Na+ and K+ permeability and other Physics concepts; and a magnetic field expression derived from the classical Ampère equation. Results from computational simulations using the finite element method suggest that the ionic permeability is strongly dependent of surface bilayer charges, the current density through a K+-channel is very less sensible to temperature changes than the current density through a Na+- channel, active Na+-channels do not directly interfere with the K+-channels around, and vice-versa, since the magnetic perturbation generated by an active channel is of short-range.

A dynamic model for organic waste management in Quebec (D-MOWIQ) as a tool to review environmental, societal and economic perspectives of a waste management policy.

PubMed

Hénault-Ethier, Louise; Martin, Jean-Philippe; Housset, Johann

2017-08-01

A dynamic systems model of organic waste management for the province of Quebec, Canada, was built. Six distinct modules taking into account social, economical and environmental issues and perspectives were included. Five scenarios were designed and tested to identify the potential consequences of different governmental and demographic combinations of decisions over time. Among these scenarios, one examines Quebec's organic waste management policy (2011-2015), while the other scenarios represent business as usual or emphasize ecology, economy or social benefits in the decision-making process. Model outputs suggest that the current governmental policy should yield favorable environmental benefits, energy production and waste valorization. The projections stemming from the current policy action plan approach the benefits gained by another scenario emphasizing the environmental aspects in the decision-making process. As expected, without the current policy and action plan in place, or business as usual, little improvements are expected in waste management compared to current trends, and strictly emphasizing economic imperatives does not favor sustainable organic waste management. Copyright © 2017. Published by Elsevier Ltd.

Biophysical and structural considerations for protein sequence evolution

PubMed Central

2011-01-01

Background Protein sequence evolution is constrained by the biophysics of folding and function, causing interdependence between interacting sites in the sequence. However, current site-independent models of sequence evolutions do not take this into account. Recent attempts to integrate the influence of structure and biophysics into phylogenetic models via statistical/informational approaches have not resulted in expected improvements in model performance. This suggests that further innovations are needed for progress in this field. Results Here we develop a coarse-grained physics-based model of protein folding and binding function, and compare it to a popular informational model. We find that both models violate the assumption of the native sequence being close to a thermodynamic optimum, causing directional selection away from the native state. Sampling and simulation show that the physics-based model is more specific for fold-defining interactions that vary less among residue type. The informational model diffuses further in sequence space with fewer barriers and tends to provide less support for an invariant sites model, although amino acid substitutions are generally conservative. Both approaches produce sequences with natural features like dN/dS < 1 and gamma-distributed rates across sites. Conclusions Simple coarse-grained models of protein folding can describe some natural features of evolving proteins but are currently not accurate enough to use in evolutionary inference. This is partly due to improper packing of the hydrophobic core. We suggest possible improvements on the representation of structure, folding energy, and binding function, as regards both native and non-native conformations, and describe a large number of possible applications for such a model. PMID:22171550

Antecedents of eating disorders and muscle dysmorphia in a non-clinical sample.

PubMed

Lamanna, J; Grieve, F G; Derryberry, W Pitt; Hakman, M; McClure, A

2010-01-01

Muscle Dysmorphia (MD) has recently been conceptualized as the male form of Eating Disorders (ED); although, it is not currently classified as an ED. The current study compares etiological models of MD symptomatology and ED symptomatology. It was hypothesized that sociocultural influences on appearance (SIA) would predict body dissatisfaction (BD), and that this relationship would be mediated by self-esteem (SE) and perfectionism (P); that BD would predict negative affect (NA); and that NA would predict MD and ED symptomatology. Two-hundred-forty-seven female and 101 male college students at a midsouth university completed the study. All participants completed measures assessing each of the constructs, and multiple regression analyses were conducted to test each model's fit. In both models, most predictor paths were significant. These results suggest similarity in symptomatology and etiological models between ED and MD.

Strange metal from local quantum chaos

NASA Astrophysics Data System (ADS)

Ben-Zion, Daniel; McGreevy, John

2018-04-01

How to make a model of a non-Fermi-liquid metal with efficient current dissipation is a long-standing problem. Results from holographic duality suggest a framework where local critical fermionic degrees of freedom provide both a source of decoherence for the Landau quasiparticle, and a sink for its momentum. This leads us to study a Kondo lattice type model with SYK models in place of the spin impurities. We find evidence for a stable phase at intermediate couplings.

Antarctic glacial history from numerical models and continental margin sediments

USGS Publications Warehouse

Barker, P.F.; Barrett, P.J.; Cooper, A. K.; Huybrechts, P.

1999-01-01

The climate record of glacially transported sediments in prograded wedges around the Antarctic outer continental shelf, and their derivatives in continental rise drifts, may be combined to produce an Antarctic ice sheet history, using numerical models of ice sheet response to temperature and sea-level change. Examination of published models suggests several preliminary conclusions about ice sheet history. The ice sheet's present high sensitivity to sea-level change at short (orbital) periods was developed gradually as its size increased, replacing a declining sensitivity to temperature. Models suggest that the ice sheet grew abruptly to 40% (or possibly more) of its present size at the Eocene-Oligocene boundary, mainly as a result of its own temperature sensitivity. A large but more gradual middle Miocene change was externally driven, probably by development of the Antarctic Circumpolar Current (ACC) and Polar Front, provided that a few million years' delay can be explained. The Oligocene ice sheet varied considerably in size and areal extent, but the late Miocene ice sheet was more stable, though significantly warmer than today's. This difference probably relates to the confining effect of the Antarctic continental margin. Present-day numerical models of ice sheet development are sufficient to guide current sampling plans, but sea-ice formation, polar wander, basal topography and ice streaming can be identified as factors meriting additional modelling effort in the future.

Treating Duchenne Cardiomyopathy in the Mouse Model by Gene Repair

DTIC Science & Technology

2017-08-01

associated virus (AAV) CRISPR (clustered regularly interspaced palindromic repeat) gene editing therapy for Duchenne cardiomyopathy in the mdx model. In...this funding period, we performed AAV CRISPR therapy in young adult mdx mice. We observed widespread dystrophin restoration in the heart on...than dystrophin-null mice. In summary, our results suggest that the low-level dystrophin restoration obtained from the current AAV CRISPR

Flow Reactor Studies with Nanosecond Pulsed Discharges at Atmospheric Pressure and Higher

DTIC Science & Technology

2013-10-01

Experiment and model analysis of low temperature C2H4/N2/O2/Ar mixtures suggest intermediate formation of nitromethane . Formation of such nitro and...Large amount of nitromethane (CH3NO2) forms within the plasma region, by CH3+NO2(+M)=CH3NO2(+M). Downstream, CH3NO2 then decomposes. • Current model

Hemispheric symmetry of the Earth's Energy Balance as a fundamental constraint on the Earth's climate

NASA Astrophysics Data System (ADS)

Stephens, G. L.; Webster, P. J.; OBrien, D. M.

2013-12-01

We currently lack a quantitative understanding of how the Earth's energy balance and the poleward energy transport adjust to different forcings that determine climate change. Currently, there are no constraints that guide this understanding. We will demonstrate that the Earth's energy balance exhibits a remarkable symmetry about the equator, and that this symmetry is a necessary condition of a steady state climate. Our analysis points to clouds as the principal agent that highly regulates this symmetry and sets the steady state. The existence of this thermodynamic steady-state constraint on climate and the symmetry required to sustain it leads to important inferences about the synchronous nature of climate changes between hemispheres, offering for example insights on mechanisms that can sustain global ice ages forced by asymmetric hemispheric solar radiation variations or how climate may respond to increases in greenhouse gas concentration. Further inferences regarding cloud effects on climate can also be deduced without resorting to the complex and intricate processes of cloud formation, whose representation continues to challenge the climate modeling community. The constraint suggests cloud feedbacks must be negative buffering the system against change. We will show that this constraint doesn't exist in the current CMIP5 model experiments and the lack of such a constraint suggests there is insufficient buffering in models in response to external forcings

Are fashion models a group at risk for eating disorders and substance abuse?

PubMed

Santonastaso, Paolo; Mondini, Silvia; Favaro, Angela

2002-01-01

Few studies to date have investigated whether in fact the prevalence of eating disorders (ED) and/or use of illicit drugs is higher among models than among other groups of females. A group of 63 professional fashion models of various nationalities were studied by means of self-reported questionnaires. They were compared with a control group of 126 female subjects recruited from the general population. Fashion models weigh significantly less than controls, but only a small percentage of them uses unhealthy methods to control their weight. The current frequency of full-syndrome ED did not differ between the groups, but partial-syndrome ED were significantly more common among fashion models than among controls. Current substance use or alcohol abuse was reported by 35% of fashion models and 12% of controls. Our findings suggest that fashion models are more at risk for partial ED and use of illicit drugs than females in the general population. Copyright 2002 S. Karger AG, Basel

The latest animal models of ovarian cancer for novel drug discovery.

PubMed

Magnotti, Elizabeth; Marasco, Wayne A

2018-03-01

Epithelial ovarian cancer is a heterogeneous disease classified into five subtypes, each with a different molecular profile. Most cases of ovarian cancer are diagnosed after metastasis of the primary tumor and are resistant to traditional platinum-based chemotherapeutics. Mouse models of ovarian cancer have been utilized to discern ovarian cancer tumorigenesis and the tumor's response to therapeutics. Areas covered: The authors provide a review of mouse models currently employed to understand ovarian cancer. This article focuses on advances in the development of orthotopic and patient-derived tumor xenograft (PDX) mouse models of ovarian cancer and discusses current humanized mouse models of ovarian cancer. Expert opinion: The authors suggest that humanized mouse models of ovarian cancer will provide new insight into the role of the human immune system in combating and augmenting ovarian cancer and aid in the development of novel therapeutics. Development of humanized mouse models will take advantage of the NSG and NSG-SGM3 strains of mice as well as new strains that are actively being derived.

An undercurrent off the east coast of Sri Lanka

NASA Astrophysics Data System (ADS)

Anutaliya, Arachaporn; Send, Uwe; McClean, Julie L.; Sprintall, Janet; Rainville, Luc; Lee, Craig M.; Priyantha Jinadasa, S. U.; Wallcraft, Alan J.; Metzger, E. Joseph

2017-12-01

The existence of a seasonally varying undercurrent along 8° N off the east coast of Sri Lanka is inferred from shipboard hydrography, Argo floats, glider measurements, and two ocean general circulation model simulations. Together, they reveal an undercurrent below 100-200 m flowing in the opposite direction to the surface current, which is most pronounced during boreal spring and summer and switches direction between these two seasons. The volume transport of the undercurrent (200-1000 m layer) can be more than 10 Sv in either direction, exceeding the transport of 1-6 Sv carried by the surface current (0-200 m layer). The undercurrent transports relatively fresher water southward during spring, while it advects more saline water northward along the east coast of Sri Lanka during summer. Although the undercurrent is potentially a pathway of salt exchange between the Arabian Sea and the Bay of Bengal, the observations and the ocean general circulation models suggest that the salinity contrast between seasons and between the boundary current and interior is less than 0.09 in the subsurface layer, suggesting a small salt transport by the undercurrent of less than 4 % of the salinity deficit in the Bay of Bengal.

Effects of tides on the cross-isobath movement of the low-salinity plume in the western Yellow and East China Seas in winter

NASA Astrophysics Data System (ADS)

Wang, Bin; Hirose, Naoki; Yuan, Dongliang; Moon, Jae-Hong; Pan, Xishan

2017-07-01

Offshore extension of the fresh Subei coast water is identified in winter based on in site salinity observation data in this and previous studies. A high-resolution regional ocean circulation model is used to investigate the cross-isobath movement of low salinity-water over the Yellow and East China Seas, and it has reproduced the salinity distribution observed in the winter of 2014-2015 successfully. The model suggests that the low-salinity water is basically degenerated back to the eastern coast of China in winter because of strong northeasterly wind. However, a part of the low-salinity water extends offshore in the southeast direction across the 20-50 m isobaths over the Yangtze Bank, which cannot be explained by either the northerly winter monsoon or the Changjiang discharge. Numerical experiments suggest that the cross-isobath transport of the soluble substances is highly attributed to the tidal residual current, flowing southeastward across 20-50 m isobaths over the whole Yangtze Bank. The results of controlled experiments also indicate that the bottom shear of the tidal current, rather than the tidal mixing, plays a significant role in the cross-isobath current during winter.

Adequacy of Current State Setbacks for Directional High-Volume Hydraulic Fracturing in the Marcellus, Barnett, and Niobrara Shale Plays.

PubMed

Haley, Marsha; McCawley, Michael; Epstein, Anne C; Arrington, Bob; Bjerke, Elizabeth Ferrell

2016-09-01

There is an increasing awareness of the multiple potential pathways leading to human health risks from hydraulic fracturing. Setback distances are a legislative method to mitigate potential risks. We attempted to determine whether legal setback distances between well-pad sites and the public are adequate in three shale plays. We reviewed geography, current statutes and regulations, evacuations, thermal modeling, air pollution studies, and vapor cloud modeling within the Marcellus, Barnett, and Niobrara Shale Plays. The evidence suggests that presently utilized setbacks may leave the public vulnerable to explosions, radiant heat, toxic gas clouds, and air pollution from hydraulic fracturing activities. Our results suggest that setbacks may not be sufficient to reduce potential threats to human health in areas where hydraulic fracturing occurs. It is more likely that a combination of reasonable setbacks with controls for other sources of pollution associated with the process will be required. Haley M, McCawley M, Epstein AC, Arrington B, Bjerke EF. 2016. Adequacy of current state setbacks for directional high-volume hydraulic fracturing in the Marcellus, Barnett, and Niobrara Shale Plays. Environ Health Perspect 124:1323-1333; http://dx.doi.org/10.1289/ehp.1510547.

Temporal Changes in the Correlates of U.S. Adolescent Electronic Cigarette Use and Utilization in Tobacco Cessation, 2011 to 2013.

PubMed

Lippert, Adam M

2017-04-01

To examine temporal changes in the correlates of experimental and current e-cigarette use and associations with tobacco quit attempts. Repeated cross-sectional analyses of data from the 2011 ( n = 17,741), 2012 ( n = 23,194), and 2013 ( n = 16,858) National Youth Tobacco Surveys-a nationally representative sample of U.S. middle and high school students. Respondents were asked about lifetime and past-month e-cigarette use, conventional cigarette use, and number of quit attempts made in the prior year among current smokers. Multinomial logistic regression models indicate higher odds of experimental or current e-cigarette use versus abstinence in the 2012 and 2013 survey years (vs. 2011). Respondents in the 2013 survey were more likely to use e-cigarettes in 2012, and they were significantly more likely to be current versus experimental users. Temporal increases in past-month e-cigarette use were uneven across demographic subgroups. Among current smokers of conventional cigarettes, fully adjusted models show that across all survey years the probability of past-month e-cigarette use was not significantly different for those who attempted to quit using tobacco in the past year from those who did not. Adolescent e-cigarette use has become more common between 2011 and 2013 and shows signs of becoming increasingly characterized by current rather than experimental use. Temporal patterns suggest that recent population increases were initially driven by select subgroups (e.g., Whites), with other subgroups contributing to the increase more recently (e.g., Black). Tobacco cessation has remained unrelated to current e-cigarette use over time, suggesting that e-cigarette use may be contributing to increased nicotine use.

Multi-tiered Approach to Development of Increased Throughput Assay Models to Assess Endocrine-Disrupting Activity of Chemicals

EPA Science Inventory

Screening for endocrine-disrupting chemicals (EDCs) requires sensitive, scalable assays. Current high-throughput screening (HTPS) approaches for estrogenic and androgenic activity yield rapid results, but many are not sensitive to physiological hormone concentrations, suggesting ...

Caught on the Web

ERIC Educational Resources Information Center

Isakson, Carol

2005-01-01

In this article, the author presents several Web sites supporting electronic presentation skills. The sites featured here will help fine-tune one's skills in modeling effective presentations and provide suggestions for managing student presentations meeting National Educational Technology Standards (NETS). Most use PowerPoint, the current industry…

Analysis of human tissue management models for medical research: preparation for implementation of the 2012 revision of the Bioethics and Safety Act of Korea.

PubMed

Ryu, Young-Joon; Kim, Hankyeom; Jang, Sejin; Koo, Young-Mo

2013-06-01

Efficient management of human tissue samples is a critical issue; the supply of samples is unable to satisfy the current demands for research. Lack of informed consent is also an ethical problem. One of the goals of the 2012 revision of Korea's Bioethics and Safety Act was to implement regulations that govern the management of human tissue samples. To remain competitive, medical institutions must prepare for these future changes. In this report, we review two tissue management models that are currently in use; model 1 is the most common system utilized by hospitals in Korea and model 2 is implemented by some of the larger institutions. We also propose three alternative models that offer advantages over the systems currently in use. Model 3 is a multi-bank model that protects the independence of physicians and pathologists. Model 4 utilizes a comprehensive single bioresource bank; although in this case, the pathologists gain control of the samples, which may make it difficult to implement. Model 5, which employs a bioresource utilization steering committee (BUSC), is viable to implement and still maintains the advantages of Model 4. To comply with the upcoming law, we suggest that physicians and pathologists in an institution should collaborate to choose one of the improved models of tissue management system that best fits for their situation.

Magnetic islands produced by reconnection in large current layers: A statistical approach to modeling at global scales

NASA Astrophysics Data System (ADS)

Fermo, Raymond Luis Lachica

2011-12-01

Magnetic reconnection is a process responsible for the conversion of magnetic energy into plasma flows in laboratory, space, and astrophysical plasmas. A product of reconnection, magnetic islands have been observed in long current layers for various space plasmas, including the magnetopause, the magnetotail, and the solar corona. In this thesis, a statistical model is developed for the dynamics of magnetic islands in very large current layers, for which conventional plasma simulations prove inadequate. An island distribution function f characterizes islands by the flux they contain psi and the area they enclose A. An integro-differential evolution equation for f describes their creation at small scales, growth due to quasi-steady reconnection, convection along the current sheet, and their coalescence with one another. The steady-state solution of the evolution equation predicts a distribution of islands in which the signature of island merging is an asymmetry in psi-- r phase space. A Hall MHD (magnetohydrodynamic) simulation of a very long current sheet with large numbers of magnetic islands is used to explore their dynamics, specifically their growth via two distinct mechanisms: quasi-steady reconnection and merging. The results of the simulation enable validation of the statistical model and benchmarking of its parameters. A PIC (particle-in-cell) simulation investigates how secondary islands form in guide field reconnection, revealing that they are born at electron skin depth scales not as islands from the tearing instability but as vortices from a flow instability. A database of 1,098 flux transfer events (FTEs) observed by Cluster between 2001 and 2003 compares favorably with the model's predictions, and also suggests island merging plays a significant role in the magnetopause. Consequently, the magnetopause is likely populated by many FTEs too small to be recognized by spacecraft instrumentation. The results of this research suggest that a complete theory of reconnection in large current sheets should account for the disparate separation of scales---from the kinetic scales at which islands are produced to the macroscale objects observed in the systems in question.

Animal models of transcranial direct current stimulation: Methods and mechanisms.

PubMed

Jackson, Mark P; Rahman, Asif; Lafon, Belen; Kronberg, Gregory; Ling, Doris; Parra, Lucas C; Bikson, Marom

2016-11-01

The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: (1) transcranial stimulation; (2) direct cortical stimulation in vivo and (3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching "quasi-uniform" assumption, which underpins translational relevance in all animal models of tDCS. Terminology such as anode, cathode, inward current, outward current, current density, electric field, and uniform are defined. Though we put key animal experiments spanning decades in perspective, our goal is not simply an exhaustive cataloging of relevant animal studies, but rather to put them in context of ongoing efforts to improve tDCS. Cellular targets, including excitatory neuronal somas, dendrites, axons, interneurons, glial cells, and endothelial cells are considered. We emphasize neurons are always depolarized and hyperpolarized such that effects of DCS on neuronal excitability can only be evaluated within subcellular regions of the neuron. Findings from animal studies on the effects of DCS on plasticity (LTP/LTD) and network oscillations are reviewed extensively. Any endogenous phenomena dependent on membrane potential changes are, in theory, susceptible to modulation by DCS. The relevance of morphological changes (galvanotropy) to tDCS is also considered, as we suggest microscopic migration of axon terminals or dendritic spines may be relevant during tDCS. A majority of clinical studies using tDCS employ a simplistic dose strategy where excitability is singularly increased or decreased under the anode and cathode, respectively. We discuss how this strategy, itself based on classic animal studies, cannot account for the complexity of normal and pathological brain function, and how recent studies have already indicated more sophisticated approaches are necessary. One tDCS theory regarding "functional targeting" suggests the specificity of tDCS effects are possible by modulating ongoing function (plasticity). Use of animal models of disease are summarized including pain, movement disorders, stroke, and epilepsy. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Animal Models of transcranial Direct Current Stimulation: Methods and Mechanisms

PubMed Central

Jackson, Mark P.; Rahman, Asif; Lafon, Belen; Kronberg, Gregory; Ling, Doris; Parra, Lucas C.; Bikson, Marom

2016-01-01

The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: 1) transcranial stimulation; 2) direct cortical stimulation in vivo and 3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching “quasi-uniform” assumption, which underpins translational relevance in all animal models of tDCS. Terminology such as anode, cathode, inward current, outward current, current density, electric field, and uniform are defined. Though we put key animal experiments spanning decades in perspective, our goal is not simply an exhaustive cataloging of relevant animal studies, but rather to put them in context of ongoing efforts to improve tDCS. Cellular targets, including excitatory neuronal somas, dendrites, axons, interneurons, glial cells, and endothelial cells are considered. We emphasize neurons are always depolarized and hyperpolarized such that effects of DCS on neuronal excitability can only be evaluated within subcellular regions of the neuron. Findings from animal studies on the effects of DCS on plasticity (LTP/LTD) and network oscillations are reviewed extensively. Any endogenous phenomena dependent on membrane potential changes are, in theory, susceptible to modulation by DCS. The relevance of morphological changes (galvanotropy) to tDCS is also considered, as we suggest microscopic migration of axon terminals or dendritic spines may be relevant during tDCS. A majority of clinical studies using tDCS employ a simplistic dose strategy where excitability is singularly increased or decreased under the anode and cathode, respectively. We discuss how this strategy, itself based on classic animal studies, cannot account for the complexity of normal and pathological brain function, and how recent studies have already indicated more sophisticated approaches are necessary. One tDCS theory regarding “functional targeting” suggests the specificity of tDCS effects are possible by modulating ongoing function (plasticity). Use of animal models of disease are summarized including pain, movement disorders, stroke, and epilepsy. PMID:27693941

Contribution of energetic and heavy ions to the plasma pressure: The 27 September to 3 October 2002 storm

NASA Astrophysics Data System (ADS)

Kronberg, E. A.; Welling, D.; Kistler, L. M.; Mouikis, C.; Daly, P. W.; Grigorenko, E. E.; Klecker, B.; Dandouras, I.

2017-09-01

Magnetospheric plasma sheet ions drift toward the Earth and populate the ring current. The ring current plasma pressure distorts the terrestrial internal magnetic field at the surface, and this disturbance strongly affects the strength of a magnetic storm. The contribution of energetic ions (>40 keV) and of heavy ions to the total plasma pressure in the near-Earth plasma sheet is not always considered. In this study, we evaluate the contribution of low-energy and energetic ions of different species to the total plasma pressure for the storm observed by the Cluster mission from 27 September until 3 October 2002. We show that the contribution of energetic ions (>40 keV) and of heavy ions to the total plasma pressure is ≃76-98.6% in the ring current and ≃14-59% in the magnetotail. The main source of oxygen ions, responsible for ≃56% of the plasma pressure of the ring current, is located at distances earthward of XGSE ≃ -13.5 RE during the main phase of the storm. The contribution of the ring current particles agrees with the observed Dst index. We model the magnetic storm using the Space Weather Modeling Framework (SWMF). We assess the plasma pressure output in the ring current for two different ion outflow models in the SWMF through comparison with observations. Both models yield reasonable results. The model which produces the most heavy ions agrees best with the observations. However, the data suggest that there is still potential for refinement in the simulations.

Reynolds Stress Distributions and the Measurement and Calculation of Eddy Viscosity in Gravity Currents

NASA Astrophysics Data System (ADS)

Kelly, R. W.; Chalk, C.; Dorrell, R. M.; Peakall, J.; Burns, A. D.; Keevil, G. M.; Thomas, R. E.; Williams, G.

2016-12-01

In the natural environment, gravity currents transport large volumes of sediment great distances and are often considered one of the most important mechanisms for sediment transport in ocean basins. Deposits from many individual submarine gravity currents, turbidites, ultimately form submarine fan systems. These are the largest sedimentary systems on the planet and contain valuable hydrocarbon reserves. Moreover, the impact of these currents on submarine technologies and seafloor infrastructure can be devastating and therefore they are of significant interest to a wide range of industries. Here we present experimental, numerical and theoretical models of time-averaged turbulent shear stresses, i.e. Reynolds stresses. Reynolds stresses can be conceptually parameterised by an eddy viscosity parameter that relates chaotic fluid motion to diffusive type processes. As such, it is a useful parameter for indicating the extent of internal mixing and is used extensively in both numerical and analytical modelling of both open-channel and gravity driven flows. However, a lack of knowledge of the turbulent structure of gravity currents limits many hydro- and morphodynamic models. High resolution 3-dimensional experimental velocity data, gathered using acoustic Doppler profiling velocimetry, enabled direct calculation of stresses and eddy viscosity. Comparison of experimental data to CFD and analytical models allowed the testing of eddy viscosity-based turbulent mixing models. The calculated eddy viscosity profile is parabolic in nature in both the upper and lower shear layers. However, an apparent breakdown in the Boussinesq hypothesis (used to calculate the eddy viscosity and upon which many numerical models are based) is observed in the region of the current around the velocity maximum. With the use of accompanying density data it is suggested that the effect of stratification on eddy viscosity is significant and alternative formulations may be required.

Rheology of Lava Flows on Europa and the Emergence of Cryovolcanic Domes

NASA Technical Reports Server (NTRS)

Quick, Lynnae C.; Glaze, Lori S.; Baloga, Steve M.

2015-01-01

There is ample evidence that Europa is currently geologically active. Crater counts suggest that the surface is no more than 90 Myr old, and cryovolcanism may have played a role in resurfacing the satellite in recent geological times. Europa's surface exhibits many putative cryovolcanic features, and previous investigations have suggested that a number of domes imaged by the Galileo spacecraft may be volcanic in origin. Consequently, several Europa domes have been modeled as viscous effusions of cryolava. However, previous models for the formation of silicic domes on the terrestrial planets contain fundamental shortcomings. Many of these shortcomings have been alleviated in our new modeling approach, which warrants a re-assessment of the possibility of cryovolcanic domes on Europa.

Charge Exchange Contribution to the Decay of the Ring Current, Measured by Energetic Neutral Atoms (ENAs)

NASA Technical Reports Server (NTRS)

Jorgensen, A. M.; Henderson, M. G.; Roelof, E. C.; Reeves, G. D.; Spence, H. E.

2001-01-01

In this paper we calculate the contribution of charge exchange to the decay of the ring current. Past works have suggested that charge exchange of ring current protons is primarily responsible for the decay of the ring current during the late recovery phase, but there is still much debate about the fast decay of the early recovery phase. We use energetic neutral atom (ENA) measurements from Polar to calculate the total ENA energy escape. To get the total ENA escape we apply a forward modeling technique, and to estimate the total ring current energy escape we use the Dessler-Parker-Sckopke relationship. We find that during the late recovery phase of the March 10, 1998 storm ENAs with energies greater than 17.5 keV can account for 75% of the estimated energy loss from the ring current. During the fast recovery the measured ENAs can only account for a small portion of the total energy loss. We also find that the lifetime of the trapped ions is significantly shorter during the fast recovery phase than during the late recovery phase, suggesting that different processes are operating during the two phases.

Plastic and evolutionary responses of plankton to environmental change are influenced by drift in ocean currents

NASA Astrophysics Data System (ADS)

Doblin, M.; van Sebille, E.

2016-02-01

The analytical framework for understanding fluctuations in ocean habitats has typically involved a Eulerian view. However, for marine microbes, this framework does not take into account their transport in dynamic seascapes, implying that our current view of change for these critical organisms may be inaccurate. Using a modelling approach, we show that generations of upper ocean microbes experience along-trajectory temperature variability up to 10°C greater than seasonal fluctuations estimated in a static frame, and that this variability depends strongly on location. These findings demonstrate that drift in ocean currents contributes to environmental fluctuation experienced by microbes and suggests that microbial populations may be adapted to upstream rather than local conditions. In an empirical test, we demonstrate that microbes in a warm, poleward flowing western boundary current (East Australian Current) have a different thermal response curve to microbes in coastal water at the same latitude (p < 0.05). Our findings suggest that advection has the capacity to influence microbial community assemblies such that water masses with relatively small thermal fluctuations select for thermal specialists, and communities with broad temperature performance curves are found in locations where ocean currents are strong or along-trajectory temperature variation is high.

Geoengineering by stratospheric SO2 injection: results from the Met Office HadGEM2 climate model and comparison with the Goddard Institute for Space Studies ModelE

NASA Astrophysics Data System (ADS)

Jones, A.; Haywood, J.; Boucher, O.; Kravitz, B.; Robock, A.

2010-03-01

We examine the response of the Met Office Hadley Centre's HadGEM2-AO climate model to simulated geoengineering by continuous injection of SO2 into the lower stratosphere, and compare the results with those from the Goddard Institute for Space Studies ModelE. The HadGEM2 simulations suggest that the SO2 injection rate considered here (5 Tg[SO2] yr-1) could defer the amount of global warming predicted under the Intergovernmental Panel on Climate Change's A1B scenario by approximately 30-35 years, although both models indicate rapid warming if geoengineering is not sustained. We find a broadly similar geographic distribution of the response to geoengineering in both models in terms of near-surface air temperature and mean June-August precipitation. The simulations also suggest that significant changes in regional climate would be experienced even if geoengineering was successful in maintaining global-mean temperature near current values.

Review of the ionospheric model for the long wave prediction capability. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferguson, J.A.

1992-11-01

The Naval Command, Control and Ocean Surveillance Center's Long Wave Prediction Capability (LWPC) has a built-in ionospheric model. The latter was defined after a review of the literature comparing measurements with calculations. Subsequent to this original specification of the ionospheric model in the LWPC, a new collection of data were obtained and analyzed. The new data were collected aboard a merchant ship named the Callaghan during a series of trans-Atlantic trips over a period of a year. This report presents a detailed analysis of the ionospheric model currently in use by the LWPC and the new model suggested by themore » shipboard measurements. We conclude that, although the fits to measurements are almost the same between the two models examined, the current LWPC model should be used because it is better than the new model for nighttime conditions at long ranges. This conclusion supports the primary use of the LWPC model for coverage assessment that requires a valid model at the limits of a transmitter's reception.... Communications, Very low frequency and low frequency, High voltage, Antennas, Measurement.« less

Group Membership, Group Change, and Intergroup Attitudes: A Recategorization Model Based on Cognitive Consistency Principles.

PubMed

Roth, Jenny; Steffens, Melanie C; Vignoles, Vivian L

2018-01-01

The present article introduces a model based on cognitive consistency principles to predict how new identities become integrated into the self-concept, with consequences for intergroup attitudes. The model specifies four concepts (self-concept, stereotypes, identification, and group compatibility) as associative connections. The model builds on two cognitive principles, balance-congruity and imbalance-dissonance, to predict identification with social groups that people currently belong to, belonged to in the past, or newly belong to. More precisely, the model suggests that the relative strength of self-group associations (i.e., identification) depends in part on the (in)compatibility of the different social groups. Combining insights into cognitive representation of knowledge, intergroup bias, and explicit/implicit attitude change, we further derive predictions for intergroup attitudes. We suggest that intergroup attitudes alter depending on the relative associative strength between the social groups and the self, which in turn is determined by the (in)compatibility between social groups. This model unifies existing models on the integration of social identities into the self-concept by suggesting that basic cognitive mechanisms play an important role in facilitating or hindering identity integration and thus contribute to reducing or increasing intergroup bias.

Group Membership, Group Change, and Intergroup Attitudes: A Recategorization Model Based on Cognitive Consistency Principles

PubMed Central

Roth, Jenny; Steffens, Melanie C.; Vignoles, Vivian L.

2018-01-01

The present article introduces a model based on cognitive consistency principles to predict how new identities become integrated into the self-concept, with consequences for intergroup attitudes. The model specifies four concepts (self-concept, stereotypes, identification, and group compatibility) as associative connections. The model builds on two cognitive principles, balance–congruity and imbalance–dissonance, to predict identification with social groups that people currently belong to, belonged to in the past, or newly belong to. More precisely, the model suggests that the relative strength of self-group associations (i.e., identification) depends in part on the (in)compatibility of the different social groups. Combining insights into cognitive representation of knowledge, intergroup bias, and explicit/implicit attitude change, we further derive predictions for intergroup attitudes. We suggest that intergroup attitudes alter depending on the relative associative strength between the social groups and the self, which in turn is determined by the (in)compatibility between social groups. This model unifies existing models on the integration of social identities into the self-concept by suggesting that basic cognitive mechanisms play an important role in facilitating or hindering identity integration and thus contribute to reducing or increasing intergroup bias. PMID:29681878

Modeling systolic pressure variation due to positive pressure ventilation.

PubMed

Messerges, Joanne

2006-01-01

Although many clinical techniques have been proposed to assess blood volume none have been established as an undisputed standard practice, Volume studies suggest systolic pressure variation (SPV) as a promising volume indicator but underlying influences on SPV are not well understood. Successful modeling of SPV will reveal the major SPV influencers, guide algorithm development to accommodate these influencers, and potentially lead to a more clinically relevant interpretation of SPV values, thus improving upon current clinical methods for assessing blood volume. This study takes a first step towards identifying SPV influencers by investigating three variations of an existing pressure-flow cardiovascular model. Each successive version introduces an additional modification in attempt to model SPV under normovolemic and hypovolemic conditions, where the last model accounts for positive pressure ventilation, venous compression, and a rightward septum shift. Under normovolemic conditions, each model yields SPV values of 5.8, 6.4, and 6.7 mmHg, respectively. Under hypovolemic conditions the results do not agree with clinical findings, suggesting these three mechanisms alone do not dictate the clinical SPV response to a decrease in volume. Model results are used to suggest improvements for future work.

Application of an interactive water simulation model in urban water management: a case study in Amsterdam.

PubMed

Leskens, J G; Brugnach, M; Hoekstra, A Y

2014-01-01

Water simulation models are available to support decision-makers in urban water management. To use current water simulation models, special expertise is required. Therefore, model information is prepared prior to work sessions, in which decision-makers weigh different solutions. However, this model information quickly becomes outdated when new suggestions for solutions arise and are therefore limited in use. We suggest that new model techniques, i.e. fast and flexible computation algorithms and realistic visualizations, allow this problem to be solved by using simulation models during work sessions. A new Interactive Water Simulation Model was applied for two case study areas in Amsterdam and was used in two workshops. In these workshops, the Interactive Water Simulation Model was positively received. It included non-specialist participants in the process of suggesting and selecting possible solutions and made them part of the accompanying discussions and negotiations. It also provided the opportunity to evaluate and enhance possible solutions more often within the time horizon of a decision-making process. Several preconditions proved to be important for successfully applying the Interactive Water Simulation Model, such as the willingness of the stakeholders to participate and the preparation of different general main solutions that can be used for further iterations during a work session.

Modeling dilute pyroclastic density currents on Earth and Mars

NASA Astrophysics Data System (ADS)

Clarke, A. B.; Brand, B. D.; De'Michieli Vitturi, M.

2013-12-01

The surface of Mars has been shaped extensively by volcanic activity, including explosive eruptions that may have been heavily influenced by water- or ice-magma interaction. However, the dynamics of associated pyroclastic density currents (PDCs) under Martian atmospheric conditions and controls on deposition and runout from such currents are poorly understood. This work combines numerical modeling with terrestrial field measurements to explore the dynamics of dilute PDC dynamics on Earth and Mars, especially as they relate to deposit characteristics. We employ two numerical approaches. Model (1) consists of simulation of axi-symmetric flow and sedimentation from a steady-state, depth-averaged density current. Equations for conservation of mass, momentum, and energy are solved simultaneously, and the effects of atmospheric entrainment, particle sedimentation, basal friction, temperature changes, and variations in current thickness and density are explored. The Rouse number and Brunt-Väisälä frequency are used to estimate the wavelength of internal gravity waves in a density-stratified current, which allows us to predict deposit dune wavelengths. The model predicts realistic runout distances and bedform wavelengths for several well-documented field cases on Earth. The model results also suggest that dilute PDCs on Mars would have runout distances up to three times that of equivalent currents on Earth and would produce longer-wavelength bedforms. In both cases results are heavily dependent on source conditions, grain-size characteristics, and entrainment and friction parameters. Model (2) relaxes several key simplifications, resulting in a fully 3D, multiphase, unsteady model that captures more details of propagation, including density stratification, and depositional processes. Using this more complex approach, we focus on the role of unsteady or pulsatory vent conditions typically associated with phreatomagmatic eruptions. Runout distances from Model (2) agree reasonably well with Model (1) results, but details of deposit distribution vary between the two models. Model (2) shows that the Earth case initially outpaces the Mars case due to faster propagation velocities associated with higher gravitational acceleration. However, the Mars currents ultimately out-distance the Earth currents due to slower particle settling rates, which also largely explain the longer wavelength bedforms. Model (2) also predicts a peak in the streamwise distribution of deposits farther from the source compared to equivalent results from Model (1), and produces more complex patterns of vertical distribution of particles in the moving current, which varies significantly in time and space. This combination of modeling and deposit data results in a powerful tool for testing hypotheses related to PDCs on Mars, potentially improving our capacity to interpret Martian features on both the outcrop (e.g., Home Plate) and regional scale (e.g., Apollinaris Mons).

Gusts and shear within hurricane eyewalls can exceed offshore wind turbine design standards

NASA Astrophysics Data System (ADS)

Worsnop, Rochelle P.; Lundquist, Julie K.; Bryan, George H.; Damiani, Rick; Musial, Walt

2017-06-01

Offshore wind energy development is underway in the U.S., with proposed sites located in hurricane-prone regions. Turbine design criteria outlined by the International Electrotechnical Commission do not encompass the extreme wind speeds and directional shifts of hurricanes stronger than category 2. We examine a hurricane's turbulent eyewall using large-eddy simulations with Cloud Model 1. Gusts and mean wind speeds near the eyewall of a category 5 hurricane exceed the current Class I turbine design threshold of 50 m s-1 mean wind and 70 m s-1 gusts. Largest gust factors occur at the eye-eyewall interface. Further, shifts in wind direction suggest that turbines must rotate or yaw faster than current practice. Although current design standards omit mention of wind direction change across the rotor layer, large values (15-50°) suggest that veer should be considered.

Gusts and shear within hurricane eyewalls can exceed offshore wind turbine design standards

DOE PAGES

Worsnop, Rochelle P.; Lundquist, Julie K.; Bryan, George H.; ...

2017-05-30

Here, offshore wind energy development is underway in the U.S., with proposed sites located in hurricane-prone regions. Turbine design criteria outlined by the International Electrotechnical Commission do not encompass the extreme wind speeds and directional shifts of hurricanes stronger than category 2. We examine a hurricane's turbulent eyewall using large-eddy simulations with Cloud Model 1. Gusts and mean wind speeds near the eyewall of a category 5 hurricane exceed the current Class I turbine design threshold of 50 m s –1 mean wind and 70 m s –1 gusts. Largest gust factors occur at the eye-eyewall interface. Further, shifts inmore » wind direction suggest that turbines must rotate or yaw faster than current practice. Although current design standards omit mention of wind direction change across the rotor layer, large values (15–50°) suggest that veer should be considered.« less

Gusts and shear within hurricane eyewalls can exceed offshore wind turbine design standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Worsnop, Rochelle P.; Lundquist, Julie K.; Bryan, George H.

Here, offshore wind energy development is underway in the U.S., with proposed sites located in hurricane-prone regions. Turbine design criteria outlined by the International Electrotechnical Commission do not encompass the extreme wind speeds and directional shifts of hurricanes stronger than category 2. We examine a hurricane's turbulent eyewall using large-eddy simulations with Cloud Model 1. Gusts and mean wind speeds near the eyewall of a category 5 hurricane exceed the current Class I turbine design threshold of 50 m s –1 mean wind and 70 m s –1 gusts. Largest gust factors occur at the eye-eyewall interface. Further, shifts inmore » wind direction suggest that turbines must rotate or yaw faster than current practice. Although current design standards omit mention of wind direction change across the rotor layer, large values (15–50°) suggest that veer should be considered.« less

Monitoring tooth profile faults in epicyclic gearboxes using synchronously averaged motor currents: Mathematical modeling and experimental validation

NASA Astrophysics Data System (ADS)

Ottewill, J. R.; Ruszczyk, A.; Broda, D.

2017-02-01

Time-varying transmission paths and inaccessibility can increase the difficulty in both acquiring and processing vibration signals for the purpose of monitoring epicyclic gearboxes. Recent work has shown that the synchronous signal averaging approach may be applied to measured motor currents in order to diagnose tooth faults in parallel shaft gearboxes. In this paper we further develop the approach, so that it may also be applied to monitor tooth faults in epicyclic gearboxes. A low-degree-of-freedom model of an epicyclic gearbox which incorporates the possibility of simulating tooth faults, as well as any subsequent tooth contact loss due to these faults, is introduced. By combining this model with a simple space-phasor model of an induction motor it is possible to show that, in theory, tooth faults in epicyclic gearboxes may be identified from motor currents. Applying the synchronous averaging approach to experimentally recorded motor currents and angular displacements recorded from a shaft mounted encoder, validate this finding. Comparison between experiments and theory highlight the influence of operating conditions, backlash and shaft couplings on the transient response excited in the currents by the tooth fault. The results obtained suggest that the method may be a viable alternative or complement to more traditional methods for monitoring gearboxes. However, general observations also indicate that further investigations into the sensitivity and robustness of the method would be beneficial.

Mesoscale Eddy Activity and Transport in the Atlantic Water Inflow Region North of Svalbard

NASA Astrophysics Data System (ADS)

Crews, L.; Sundfjord, A.; Albretsen, J.; Hattermann, T.

2018-01-01

Mesoscale eddies are known to transport heat and biogeochemical properties from Arctic Ocean boundary currents to basin interiors. Previous hydrographic surveys and model results suggest that eddy formation may be common in the Atlantic Water (AW) inflow area north of Svalbard, but no quantitative eddy survey has yet been done for the region. Here vorticity and water property signatures are used to identify and track AW eddies in an eddy-resolving sea ice-ocean model. The boundary current sheds AW eddies along most of the length of the continental slope considered, from the western Yermak Plateau to 40°E, though eddies forming east of 20°E are likely more important for slope-to-basin transport. Eddy formation seasonality reflects seasonal stability properties of the boundary current in the eastern portion of the study domain, but on and immediately east of the Yermak Plateau enhanced eddy formation during summer merits further investigation. AW eddies tend to be anticyclonic, have radii close to the local deformation radius, and be centered in the halocline. They transport roughly 0.16 Sv of AW and, due to their warm cores, 1.0 TW away from the boundary current. These findings suggest eddies may be important for halocline ventilation in the Eurasian Basin, as has been shown for Pacific Water eddies in the Canadian Basin.

Pre-anthropocene mercury residues in North American freshwater fish.

PubMed

Hope, Bruce K; Louch, Jeff

2014-04-01

Mercury (Hg) has been entering the environment from both natural and anthropogenic sources for millennia, and humans have been influencing its environmental transport and fate from well before the Industrial Revolution. Exposure to Hg (as neurotoxic monomethylmercury [MeHg]) occurs primarily through consumption of finfish, shellfish, and marine mammals, and regulatory limits for MeHg concentrations in fish tissue have steadily decreased as information on its health impacts has become available. These facts prompted us to consider 2 questions: 1) What might the MeHg levels in fish tissue have been in the pre-Anthropocene, before significant human impacts on the environment? and 2) How would these pre-Anthropocene levels have compared with current regulatory criteria for MeHg residues in fish tissue? We addressed the first question by estimating pre-Anthropocene concentrations of MeHg in the tissues of prey and predatory fish with an integrated Hg speciation, transport, fate, and food web model (SERAFM), using estimated Hg concentrations in soil, sediment, and atmospheric deposition before the onset of significant human activity (i.e., ≤2000 BCE). Model results show MeHg residues in fish varying depending on the characteristics of the modeled water body, which suggests that Hg in fish tissue is best considered at the scale of individual watersheds or water bodies. We addressed the second question by comparing these model estimates with current regulatory criteria and found that MeHg residues in predatory (but not prey) fish could have approached or exceeded these criteria in some water bodies during the pre-Anthropocene. This suggests that the possibility of naturally occurring levels of Hg in fish below which it is not possible to descend, regardless of where those levels stand with respect to current regulatory limits. Risk management decisions made under these circumstances have the potential to be ineffectual, frustrating, and costly for decision makers and stakeholders alike, suggesting the need for regulatory flexibility when addressing the issue of Hg in fish. © 2013 SETAC.

The Therapeutic Process in Clinical Social Work.

ERIC Educational Resources Information Center

Siporin, Max

1983-01-01

Suggests that current outmoded and inadequate conceptions of the therapeutic process are a major obstacle to the advancement of clinical social work practice. Presents an integrative ecosystem model that expresses the distinctive social work concern with person, situation, and helping relationship, in their reciprocal psychodynamic and…

Alternative Statistical Frameworks for Student Growth Percentile Estimation

ERIC Educational Resources Information Center

Lockwood, J. R.; Castellano, Katherine E.

2015-01-01

This article suggests two alternative statistical approaches for estimating student growth percentiles (SGP). The first is to estimate percentile ranks of current test scores conditional on past test scores directly, by modeling the conditional cumulative distribution functions, rather than indirectly through quantile regressions. This would…

Attachment in Middle Childhood: Associations with Information Processing

ERIC Educational Resources Information Center

Zimmermann, Peter; Iwanski, Alexandra

2015-01-01

Attachment theory suggests that internal working models of self and significant others influence adjustment during development by controlling information processing and self-regulation. We provide a conceptual overview on possible mechanisms linking attachment and information processing and review the current literature in middle childhood.…

Rectification of nanopores in aprotic solvents--transport properties of nanopores with surface dipoles.

PubMed

Plett, Timothy; Shi, Wenqing; Zeng, Yuhan; Mann, William; Vlassiouk, Ivan; Baker, Lane A; Siwy, Zuzanna S

2015-12-07

Nanopores have become a model system to understand transport properties at the nanoscale. We report experiments and modeling of ionic current in aprotic solvents with different dipole moments through conically shaped nanopores in a polycarbonate film and through glass nanopipettes. We focus on solutions of the salt LiClO4, which is of great importance in modeling lithium based batteries. Results presented suggest ion current rectification observed results from two effects: (i) adsorption of Li(+) ions to the pore walls, and (ii) a finite dipole moment rendered by adsorbed solvent molecules. Properties of surfaces in various solvents were probed by means of scanning ion conductance microscopy, which confirmed existence of an effectively positive surface potential in aprotic solvents with high dipole moments.

Studying strategic interaction under environmental and economic uncertainties among water users in the Zambezi River Basin - From descriptive analysis to institutional design for better transboundary management

NASA Astrophysics Data System (ADS)

Beck, L.; Siegfried, T. U.; Bernauer, T.

2009-12-01

The Zambezi River Basin (ZRB) is one of the largest freshwater catchments in Africa and worldwide. Consumptive water use in the ZRB is currently estimated at 15 - 20 percent of total runoff. This suggests many development possibilities, particularly for irrigated agriculture and hydropower production. The key drivers in the basin are population development on the demand side as well as uncertain impacts from climate change for supply. Development plans of the riparian countries suggest that consumptive water use might increase up to 40 percent of total runoff by 2025. This suggests that expanding water use in the Zambezi basin could become a source of disputes among the eight riparian countries. We study the surface water allocation in the basin by means of a couple hydrological-economic modeling approach. A conceptual lumped-parameter rainfall-runoff model for the ZRB was constructed and calibrated on the best available runoff data for the basin. Water users are modeled based on an agent-based framework and implemented as distributed sequential decision makers that act in an uncertain environment. Given the current non-cooperative status quo, we use the stochastic optimization technique of reinforcement learning to model the individual agents’ behavior. Their goals include the maximization of a) their long-term reward as conditioned on the state of the multi-agent system and b) the immediate reward obtained from operational decisions of reservoirs and water diversions under their control. We feed a wide range of water demand drivers as well as climate change predictions into the model and assess agents’ responses and the resulting implications for runoff at key points in the water catchment, including Victoria Falls, Kariba reservoir, Kafue Gorge, and Cahora Bassa reservoir in the downstream. It will be shown that considerable benefits exist if the current non-cooperative regime is replaced by a basin-wide, coordinated allocation strategy that regulates water storage and allocation in this complex multi-reservoir river basin. Benefits increase along the river towards the downstream, which suggests the establishment of an upstream-downstream compensation approach. The latter considers tradeoffs from water and hydropower exchanges during respective seasons and locations of peak demand.

Model falsifiability and climate slow modes

NASA Astrophysics Data System (ADS)

Essex, Christopher; Tsonis, Anastasios A.

2018-07-01

The most advanced climate models are actually modified meteorological models attempting to capture climate in meteorological terms. This seems a straightforward matter of raw computing power applied to large enough sources of current data. Some believe that models have succeeded in capturing climate in this manner. But have they? This paper outlines difficulties with this picture that derive from the finite representation of our computers, and the fundamental unavailability of future data instead. It suggests that alternative windows onto the multi-decadal timescales are necessary in order to overcome the issues raised for practical problems of prediction.

The effects of modeling contingencies in the treatment of food selectivity in children with autism.

PubMed

Fu, Sherrene B; Penrod, Becky; Fernand, Jonathan K; Whelan, Colleen M; Griffith, Kristin; Medved, Shannon

2015-11-01

The current study investigated the effectiveness of stating and modeling contingencies in increasing food consumption for two children with food selectivity. Results suggested that stating and modeling a differential reinforcement (DR) contingency for food consumption was effective in increasing consumption of two target foods for one child, and stating and modeling a DR plus nonremoval of the spoon contingency was effective in increasing consumption of the remaining food for the first child and all target foods for the second child. © The Author(s) 2015.

Boundary current-controlled turbidite deposition: A sedimentation model for the Southern Nares Abyssal Plain, Western North Atlantic

NASA Astrophysics Data System (ADS)

Kuijpers, A.; Duin, E. J. Th.

1986-03-01

Examination of 38 sediment cores, bottom photographs, 7,000 km of 3.5 kHz reflection profiles and other seismic data from the southern part of the Nares Abyssal Plain suggests that complex sedimentary patterns and high sedimentation rates can be largely attributed to effects of a deep boundary current flowing eastward along the north flank of the Greater Antilles Outer Ridge. It is concluded that the areal dispersal pattern of turbidites on the plain results mainly from Quaternary climatically-induced fluctuations of the boundary current intensity.

Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

PubMed

Faville, R A; Pullan, A J; Sanders, K M; Koh, S D; Lloyd, C M; Smith, N P

2009-06-17

Spontaneously rhythmic pacemaker activity produced by interstitial cells of Cajal (ICC) is the result of the entrainment of unitary potential depolarizations generated at intracellular sites termed pacemaker units. In this study, we present a mathematical modeling framework that quantitatively represents the transmembrane ion flows and intracellular Ca2+ dynamics from a single ICC operating over the physiological membrane potential range. The mathematical model presented here extends our recently developed biophysically based pacemaker unit modeling framework by including mechanisms necessary for coordinating unitary potential events, such as a T-Type Ca2+ current, Vm-dependent K+ currents, and global Ca2+ diffusion. Model simulations produce spontaneously rhythmic slow wave depolarizations with an amplitude of 65 mV at a frequency of 17.4 cpm. Our model predicts that activity at the spatial scale of the pacemaker unit is fundamental for ICC slow wave generation, and Ca2+ influx from activation of the T-Type Ca2+ current is required for unitary potential entrainment. These results suggest that intracellular Ca2+ levels, particularly in the region local to the mitochondria and endoplasmic reticulum, significantly influence pacing frequency and synchronization of pacemaker unit discharge. Moreover, numerical investigations show that our ICC model is capable of qualitatively replicating a wide range of experimental observations.

The impact of accelerating faster than exponential population growth on genetic variation.

PubMed

Reppell, Mark; Boehnke, Michael; Zöllner, Sebastian

2014-03-01

Current human sequencing projects observe an abundance of extremely rare genetic variation, suggesting recent acceleration of population growth. To better understand the impact of such accelerating growth on the quantity and nature of genetic variation, we present a new class of models capable of incorporating faster than exponential growth in a coalescent framework. Our work shows that such accelerated growth affects only the population size in the recent past and thus large samples are required to detect the models' effects on patterns of variation. When we compare models with fixed initial growth rate, models with accelerating growth achieve very large current population sizes and large samples from these populations contain more variation than samples from populations with constant growth. This increase is driven almost entirely by an increase in singleton variation. Moreover, linkage disequilibrium decays faster in populations with accelerating growth. When we instead condition on current population size, models with accelerating growth result in less overall variation and slower linkage disequilibrium decay compared to models with exponential growth. We also find that pairwise linkage disequilibrium of very rare variants contains information about growth rates in the recent past. Finally, we demonstrate that models of accelerating growth may substantially change estimates of present-day effective population sizes and growth times.

Multiphase modeling of channelized pyroclastic density currents and the effect of confinement on mobility and entrainment

NASA Astrophysics Data System (ADS)

Kubo, A. I.; Dufek, J.

2017-12-01

Around explosive volcanic centers such as Mount Saint Helens, pyroclastic density currents (PDCs) pose a great risk to life and property. Understanding of the mobility and dynamics of PDCs and other gravity currents is vital to mitigating hazards of future eruptions. Evidence from pyroclastic deposits at Mount Saint Helens and one-dimensional modeling suggest that channelization of flows effectively increases run out distances. Dense flows are thought to scour and erode the bed leading to confinement for subsequent flows and could result in significant changes to predicted runout distance and mobility. Here, we present the results of three-dimensional multiphase models comparing confined and unconfined flows using simplified geometries. We focus on bed stress conditions as a proxy for conditions that could influence subsequent erosion and self-channelization. We also explore the controls on gas entrainment in all scenarios to determine how confinement impacts the particle concentration gradient, granular interactions, and mobility.

Surfzone Currents Over Irregular Bathymetry: Drifter Observations and Numerical Model Results

NASA Astrophysics Data System (ADS)

Schmidt, W. E.; Slinn, D. N.; Guza, R. T.

2002-12-01

Surfzone currents on alongshore variable bathymetry were observed with recently developed GPS-tracked drifters and numerically modeled with the time-dependent, nonlinear shallow water equations. These currents, forced by alongshore inhomogeneous pressure and radiation stress gradients, contain flow features difficult to resolve with fixed instrument arrays, such as rips, eddies, and meanders. Drifters were repeatedly released and recovered near Scripps Beach, La Jolla, California, in July 2000, 2001, and 2002. The most recent deployment of 10 drifters yielded about 32 hours of drifter data for each 5 hour deployment day. Offshore wave heights were moderate, between 0.3-1.0 m. The bathymetry, measured over a 600-700 m alongshore span with a GPS- and sonar-equipped jetski (2001 and 2002 deployments), was alongshore inhomogeneous primarily where an irregularly shaped bar-trough feature spanned the surf zone. The model simulations suggest that the alongshore inhomogeneous bathymetry strongly influences the location and strength of the observed flow features. Research supported by the California Sea Grant College Program and the Office of Naval Research.

Protective effects of vaccines against Bordetella parapertussis in a mouse intranasal challenge model.

PubMed

Komatsu, Eiji; Yamaguchi, Fuminori; Eguchi, Masahiro; Watanabe, Mineo

2010-06-17

Bordetella parapertussis causes typical whooping cough, as does Bordetella pertussis. However, current commercial vaccines are ineffective against B. parapertussis. In an effort to develop vaccines that are effective in protecting against both B. pertussis and B. parapertussis, we examined the protective effects of vaccines prepared from whole-cells and from recombinant proteins derived from B. parapertussis in a mouse intranasal challenge model. We confirmed current pertussis vaccines did not induce protective immunity against B. parapertussis in the mouse model. A whole-cell vaccine prepared from B. parapertussis induced protective immunity against B. parapertussis but not against B. pertussis, suggesting a combination of a current pertussis vaccine with a whole-cell parapertussis vaccine might prevent whooping cough caused by both species of Bordetella. We also found that filamentous hemagglutinin was a protective antigen of B. parapertussis. Our observations should lead to the development of new pertussis vaccines that can control the two prevalent forms of whooping cough.

Statistical Forecasting of Current and Future Circum-Arctic Ground Temperatures and Active Layer Thickness

NASA Astrophysics Data System (ADS)

Aalto, J.; Karjalainen, O.; Hjort, J.; Luoto, M.

2018-05-01

Mean annual ground temperature (MAGT) and active layer thickness (ALT) are key to understanding the evolution of the ground thermal state across the Arctic under climate change. Here a statistical modeling approach is presented to forecast current and future circum-Arctic MAGT and ALT in relation to climatic and local environmental factors, at spatial scales unreachable with contemporary transient modeling. After deploying an ensemble of multiple statistical techniques, distance-blocked cross validation between observations and predictions suggested excellent and reasonable transferability of the MAGT and ALT models, respectively. The MAGT forecasts indicated currently suitable conditions for permafrost to prevail over an area of 15.1 ± 2.8 × 106 km2. This extent is likely to dramatically contract in the future, as the results showed consistent, but region-specific, changes in ground thermal regime due to climate change. The forecasts provide new opportunities to assess future Arctic changes in ground thermal state and biogeochemical feedback.

On the Origin of Pulsations of Sub-THz Emission from Solar Flares

NASA Astrophysics Data System (ADS)

Zaitsev, V. V.; Stepanov, A. V.; Kaufmann, P.

2014-08-01

We propose a model to explain fast pulsations in sub-THz emission from solar flares. The model is based on the approach of a flaring loop as an equivalent electric circuit and explains the pulse-repetition rate, the high-quality factor, Q≥103, low modulation depth, pulse synchronism at different frequencies, and the dependence of the pulse-repetition rate on the emission flux, observed by Kaufmann et al. ( Astrophys. J. 697, 420, 2009). We solved the nonlinear equation for electric current oscillations using a Van der Pol method and found the steady-state value for the amplitude of the current oscillations. Using the pulse rate variation during the flare on 4 November 2003, we found a decrease of the electric current from 1.7×1012 A in the flare maximum to 4×1010 A just after the burst. Our model is consistent with the plasma mechanism of sub-THz emission suggested recently by Zaitsev, Stepanov, and Melnikov ( Astron. Lett. 39, 650, 2013).

Observations and Simulations of the Impact of Wave-Current Interaction on Wave Direction in the Surf Zone

NASA Astrophysics Data System (ADS)

Hopkins, Julia; Elgar, Steve; Raubenheimer, Britt

2017-04-01

Accurately characterizing the interaction of waves and currents can improve predictions of wave propagation and subsequent sediment transport in the nearshore. Along the southern shoreline of Martha's Vineyard, MA, waves propagate across strong tidal currents as they shoal, providing an ideal environment for investigating wave-current interaction. Wave directions and mean currents observed for two 1-month-long periods in 7- and 2-m water depths along 11 km of the Martha's Vineyard shoreline have strong tidal modulations. Wave directions shift by as much as 70 degrees over a tidal cycle in 7 m depth, and by as much as 25 degrees in 2 m depth. The magnitude of the tidal modulations in the wave field decreases alongshore to the west, consistent with the observed decrease in tidal currents from 2.1 to 0.2 m/s. The observations are reproduced accurately by a numerical model (SWAN and Deflt3D-FLOW) that simulates waves and currents over the observed bathymetry. Model simulations with and without wave-current interaction and tidal depth changes demonstrate that the observed tidal modulations of the wave field primarily are caused by wave-current interaction and not by tidal changes to water depths over the nearby complex shoals. Sediment transport estimates from simulated wave conditions using a range of tidal currents and offshore wave fields indicate that the modulation of the wave field at Martha's Vineyard can impact the direction of wave-induced alongshore sediment transport, sometimes driving transport opposing the direction of the offshore incident wave field. As such, the observations and model simulations suggest the importance of wave-current interaction to tidally averaged transport in mixed-energy wave-and-current nearshore environments. Supported by ASD(R&E), NSF, NOAA (Sea Grant), and ONR.

Diffuse cloud chemistry. [in interstellar matter

NASA Technical Reports Server (NTRS)

Van Dishoeck, Ewine F.; Black, John H.

1988-01-01

The current status of models of diffuse interstellar clouds is reviewed. A detailed comparison of recent gas-phase steady-state models shows that both the physical conditions and the molecular abundances in diffuse clouds are still not fully understood. Alternative mechanisms are discussed and observational tests which may discriminate between the various models are suggested. Recent developments regarding the velocity structure of diffuse clouds are mentioned. Similarities and differences between the chemistries in diffuse clouds and those in translucent and high latitude clouds are pointed out.

Extreme Conditions Modeling Workshop Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coe, R. G.; Neary, V. S.; Lawson, M. J.

2014-07-01

Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, NM on May 13th-14th, 2014. The objective of the workshop was to review the current state of knowledge on how to model WECs in extreme conditions (e.g. hurricanes and other large storms) and to suggest how U.S. Department of Energy (DOE) and national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry.

Is there something quantum-like about the human mental lexicon?

PubMed Central

Bruza, Peter; Kitto, Kirsty; Nelson, Douglas; McEvoy, Cathy

2010-01-01

Following an early claim by Nelson & McEvoy (35) suggesting that word associations can display ‘spooky action at a distance behaviour’, a serious investigation of the potentially quantum nature of such associations is currently underway. In this paper quantum theory is proposed as a framework suitable for modelling the human mental lexicon, specifically the results obtained from both intralist and extralist word association experiments. Some initial models exploring this hypothesis are discussed, and experiments capable of testing these models proposed. PMID:20224806

Modelling digital thunder

NASA Astrophysics Data System (ADS)

Blanco, Francesco; La Rocca, Paola; Petta, Catia; Riggi, Francesco

2009-01-01

An educational model simulation of the sound produced by lightning in the sky has been employed to demonstrate realistic signatures of thunder and its connection to the particular structure of the lightning channel. Algorithms used in the past have been revisited and implemented, making use of current computer techniques. The basic properties of the mathematical model, together with typical results and suggestions for additional developments are discussed. The paper is intended as a teaching aid for students and teachers in the context of introductory physics courses at university level.

Adapting to change: The role of the right hemisphere in mental model building and updating.

PubMed

Filipowicz, Alex; Anderson, Britt; Danckert, James

2016-09-01

We recently proposed that the right hemisphere plays a crucial role in the processes underlying mental model building and updating. Here, we review the evidence we and others have garnered to support this novel account of right hemisphere function. We begin by presenting evidence from patient work that suggests a critical role for the right hemisphere in the ability to learn from the statistics in the environment (model building) and adapt to environmental change (model updating). We then provide a review of neuroimaging research that highlights a network of brain regions involved in mental model updating. Next, we outline specific roles for particular regions within the network such that the anterior insula is purported to maintain the current model of the environment, the medial prefrontal cortex determines when to explore new or alternative models, and the inferior parietal lobule represents salient and surprising information with respect to the current model. We conclude by proposing some future directions that address some of the outstanding questions in the field of mental model building and updating. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Cerebellum as a forward but not inverse model in visuomotor adaptation task: a tDCS-based and modeling study.

PubMed

Yavari, Fatemeh; Mahdavi, Shirin; Towhidkhah, Farzad; Ahmadi-Pajouh, Mohammad-Ali; Ekhtiari, Hamed; Darainy, Mohammad

2016-04-01

Despite several pieces of evidence, which suggest that the human brain employs internal models for motor control and learning, the location of these models in the brain is not yet clear. In this study, we used transcranial direct current stimulation (tDCS) to manipulate right cerebellar function, while subjects adapt to a visuomotor task. We investigated the effect of this manipulation on the internal forward and inverse models by measuring two kinds of behavior: generalization of training in one direction to neighboring directions (as a proxy for inverse models) and localization of the hand position after movement without visual feedback (as a proxy for forward model). The experimental results showed no effect of cerebellar tDCS on generalization, but significant effect on localization. These observations support the idea that the cerebellum is a possible brain region for internal forward, but not inverse model formation. We also used a realistic human head model to calculate current density distribution in the brain. The result of this model confirmed the passage of current through the cerebellum. Moreover, to further explain some observed experimental results, we modeled the visuomotor adaptation process with the help of a biologically inspired method known as population coding. The effect of tDCS was also incorporated in the model. The results of this modeling study closely match our experimental data and provide further evidence in line with the idea that tDCS manipulates FM's function in the cerebellum.

Modelling fatigue and the use of fatigue models in work settings.

PubMed

Dawson, Drew; Ian Noy, Y; Härmä, Mikko; Akerstedt, Torbjorn; Belenky, Gregory

2011-03-01

In recent years, theoretical models of the sleep and circadian system developed in laboratory settings have been adapted to predict fatigue and, by inference, performance. This is typically done using the timing of prior sleep and waking or working hours as the primary input and the time course of the predicted variables as the primary output. The aim of these models is to provide employers, unions and regulators with quantitative information on the likely average level of fatigue, or risk, associated with a given pattern of work and sleep with the goal of better managing the risk of fatigue-related errors and accidents/incidents. The first part of this review summarises the variables known to influence workplace fatigue and draws attention to the considerable variability attributable to individual and task variables not included in current models. The second part reviews the current fatigue models described in the scientific and technical literature and classifies them according to whether they predict fatigue directly by using the timing of prior sleep and wake (one-step models) or indirectly by using work schedules to infer an average sleep-wake pattern that is then used to predict fatigue (two-step models). The third part of the review looks at the current use of fatigue models in field settings by organizations and regulators. Given their limitations it is suggested that the current generation of models may be appropriate for use as one element in a fatigue risk management system. The final section of the review looks at the future of these models and recommends a standardised approach for their use as an element of the 'defenses-in-depth' approach to fatigue risk management. Copyright © 2010 Elsevier Ltd. All rights reserved.

Uniting paradigms of connectivity in marine ecology.

PubMed

Brown, Christopher J; Harborne, Alastair R; Paris, Claire B; Mumby, Peter J

2016-09-01

The connectivity of marine organisms among habitat patches has been dominated by two independent paradigms with distinct conservation strategies. One paradigm is the dispersal of larvae on ocean currents, which suggests networks of marine reserves. The other is the demersal migration of animals from nursery to adult habitats, requiring the conservation of connected ecosystem corridors. Here, we suggest that a common driver, wave exposure, links larval and demersal connectivity across the seascape. To study the effect of linked connectivities on fish abundance at reefs, we parameterize a demographic model for The Bahamas seascape using maps of habitats, empirically forced models of wave exposure and spatially realistic three-dimensional hydrological models of larval dispersal. The integrated empirical-modeling approach enabled us to study linked connectivity on a scale not currently possible by purely empirical studies. We find sheltered environments not only provide greater nursery habitat for juvenile fish but larvae spawned on adjacent reefs have higher retention, thereby creating a synergistic increase in fish abundance. Uniting connectivity paradigms to consider all life stages simultaneously can help explain the evolution of nursery habitat use and simplifies conservation advice: Reserves in sheltered environments have desirable characteristics for biodiversity conservation and can support local fisheries through adult spillover. © 2016 by the Ecological Society of America.

The spectral basis of optimal error field correction on DIII-D

DOE PAGES

Paz-Soldan, Carlos A.; Buttery, Richard J.; Garofalo, Andrea M.; ...

2014-04-28

Here, experimental optimum error field correction (EFC) currents found in a wide breadth of dedicated experiments on DIII-D are shown to be consistent with the currents required to null the poloidal harmonics of the vacuum field which drive the kink mode near the plasma edge. This allows the identification of empirical metrics which predict optimal EFC currents with accuracy comparable to that of first- principles modeling which includes the ideal plasma response. While further metric refinements are desirable, this work suggests optimal EFC currents can be effectively fed-forward based purely on knowledge of the vacuum error field and basic equilibriummore » properties which are routinely calculated in real-time.« less

GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia.

PubMed

Gonzalez-Burgos, Guillermo; Fish, Kenneth N; Lewis, David A

2011-01-01

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning. Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission. A major role of GABA-mediated transmission may be producing synchronized network oscillations which are currently hypothesized to be essential for normal cognitive function. Therefore, cognitive deficits in schizophrenia may result from a GABA synapse dysfunction that disturbs neural synchrony. Here, we highlight recent studies further suggesting alterations of GABA transmission and network oscillations in schizophrenia. We also review current models for the mechanisms of GABA-mediated synchronization of neural activity, focusing on parvalbumin-positive GABA neurons, which are altered in schizophrenia and whose function has been strongly linked to the production of neural synchrony. Alterations of GABA signaling that impair gamma oscillations and, as a result, cognitive function suggest paths for novel therapeutic interventions.

Postglacial species displacement in Triturus newts deduced from asymmetrically introgressed mitochondrial DNA and ecological niche models

PubMed Central

2012-01-01

Background If the geographical displacement of one species by another is accompanied by hybridization, mitochondrial DNA can introgress asymmetrically, from the outcompeted species into the invading species, over a large area. We explore this phenomenon using the two parapatric crested newt species, Triturus macedonicus and T. karelinii, distributed on the Balkan Peninsula in south-eastern Europe, as a model. Results We first delimit a ca. 54,000 km2 area in which T. macedonicus contains T. karelinii mitochondrial DNA. This introgression zone bisects the range of T. karelinii, cutting off a T. karelinii enclave. The high similarity of introgressed mitochondrial DNA haplotypes with those found in T. karelinii suggests a recent transfer across the species boundary. We then use ecological niche modeling to explore habitat suitability of the location of the present day introgression zone under current, mid-Holocene and Last Glacial Maximum conditions. This area was inhospitable during the Last Glacial Maximum for both species, but would have been habitable at the mid-Holocene. Since the mid-Holocene, habitat suitability generally increased for T. macedonicus, whereas it decreased for T. karelinii. Conclusion The presence of a T. karelinii enclave suggests that T. karelinii was the first to colonize the area where the present day introgression zone is positioned after the Last Glacial Maximum. Subsequently, we propose T. karelinii was outcompeted by T. macedonicus, which captured T. karelinii mitochondrial DNA via introgressive hybridization in the process. Ecological niche modeling suggests that this replacement was likely facilitated by a shift in climate since the mid-Holocene. We suggest that the northwestern part of the current introgression zone was probably never inhabited by T. karelinii itself, and that T. karelinii mitochondrial DNA spread there through T. macedonicus exclusively. Considering the spatial distribution of the introgressed mitochondrial DNA and the signal derived from ecological niche modeling, we do not favor the hypothesis that foreign mitochondrial DNA was pulled into the T. macedonicus range by natural selection. PMID:22935041

Postglacial species displacement in Triturus newts deduced from asymmetrically introgressed mitochondrial DNA and ecological niche models.

PubMed

Wielstra, Ben; Arntzen, Jan W

2012-08-30

If the geographical displacement of one species by another is accompanied by hybridization, mitochondrial DNA can introgress asymmetrically, from the outcompeted species into the invading species, over a large area. We explore this phenomenon using the two parapatric crested newt species, Triturus macedonicus and T. karelinii, distributed on the Balkan Peninsula in south-eastern Europe, as a model. We first delimit a ca. 54,000 km(2) area in which T. macedonicus contains T. karelinii mitochondrial DNA. This introgression zone bisects the range of T. karelinii, cutting off a T. karelinii enclave. The high similarity of introgressed mitochondrial DNA haplotypes with those found in T. karelinii suggests a recent transfer across the species boundary. We then use ecological niche modeling to explore habitat suitability of the location of the present day introgression zone under current, mid-Holocene and Last Glacial Maximum conditions. This area was inhospitable during the Last Glacial Maximum for both species, but would have been habitable at the mid-Holocene. Since the mid-Holocene, habitat suitability generally increased for T. macedonicus, whereas it decreased for T. karelinii. The presence of a T. karelinii enclave suggests that T. karelinii was the first to colonize the area where the present day introgression zone is positioned after the Last Glacial Maximum. Subsequently, we propose T. karelinii was outcompeted by T. macedonicus, which captured T. karelinii mitochondrial DNA via introgressive hybridization in the process. Ecological niche modeling suggests that this replacement was likely facilitated by a shift in climate since the mid-Holocene. We suggest that the northwestern part of the current introgression zone was probably never inhabited by T. karelinii itself, and that T. karelinii mitochondrial DNA spread there through T. macedonicus exclusively. Considering the spatial distribution of the introgressed mitochondrial DNA and the signal derived from ecological niche modeling, we do not favor the hypothesis that foreign mitochondrial DNA was pulled into the T. macedonicus range by natural selection.

An oilspill trajectory analysis model with a variable wind deflection angle

USGS Publications Warehouse

Samuels, W.B.; Huang, N.E.; Amstutz, D.E.

1982-01-01

The oilspill trajectory movement algorithm consists of a vector sum of the surface drift component due to wind and the surface current component. In the U.S. Geological Survey oilspill trajectory analysis model, the surface drift component is assumed to be 3.5% of the wind speed and is rotated 20 degrees clockwise to account for Coriolis effects in the Northern Hemisphere. Field and laboratory data suggest, however, that the deflection angle of the surface drift current can be highly variable. An empirical formula, based on field observations and theoretical arguments relating wind speed to deflection angle, was used to calculate a new deflection angle at each time step in the model. Comparisons of oilspill contact probabilities to coastal areas calculated for constant and variable deflection angles showed that the model is insensitive to this changing angle at low wind speeds. At high wind speeds, some statistically significant differences in contact probabilities did appear. ?? 1982.

A numerical model for charge transport and energy conversion of perovskite solar cells.

PubMed

Zhou, Yecheng; Gray-Weale, Angus

2016-02-14

Based on the continuity equations and Poisson's equation, we developed a numerical model for perovskite solar cells. Due to different working mechanisms, the model for perovskite solar cells differs from that of silicon solar cells and Dye Sensitized Solar Cells. The output voltage and current are calculated differently, and in a manner suited in particular to perovskite organohalides. We report a test of our equations against experiment with good agreement. Using this numerical model, it was found that performances of solar cells increase with charge carrier's lifetimes, mobilities and diffusion lengths. The open circuit voltage (Voc) of a solar cell is dependent on light intensities, and charge carrier lifetimes. Diffusion length and light intensity determine the saturated current (Jsc). Additionally, three possible guidelines for the design and fabrication of perovskite solar cells are suggested by our calculations. Lastly, we argue that concentrator perovskite solar cells are promising.

An assessment of finite-element modeling techniques for thick-solid/thin-shell joints analysis

NASA Technical Reports Server (NTRS)

Min, J. B.; Androlake, S. G.

1993-01-01

The subject of finite-element modeling has long been of critical importance to the practicing designer/analyst who is often faced with obtaining an accurate and cost-effective structural analysis of a particular design. Typically, these two goals are in conflict. The purpose is to discuss the topic of finite-element modeling for solid/shell connections (joints) which are significant for the practicing modeler. Several approaches are currently in use, but frequently various assumptions restrict their use. Such techniques currently used in practical applications were tested, especially to see which technique is the most ideally suited for the computer aided design (CAD) environment. Some basic thoughts regarding each technique are also discussed. As a consequence, some suggestions based on the results are given to lead reliable results in geometrically complex joints where the deformation and stress behavior are complicated.

Clinicians’ Use of Personality Disorder Models within a Particular Treatment Setting: A Longitudinal Comparison of Temporal Consistency and Clinical Utility

PubMed Central

Samuel, Douglas B.; Widiger, Thomas A.

2012-01-01

An active line of current investigation is how the five-factor model (FFM) of personality disorder might be applied by clinicians and particularly, how clinically useful this model is in comparison to the existing nomenclature. The current study is the first to investigate the temporal consistency of clinicians’ application of the FFM and the DSM-IV-TR to their own patients. Results indicated that FFM ratings were relatively stable over six-months of treatment, supporting their use by clinicians, but also indexed potentially important clinical changes. Additionally, ratings of utility provided by the clinicians suggested that the FFM was more useful for clinical decision making than was the DSM-IV-TR model. We understand the clinical utility findings within the context of previous research indicating that the FFM is most useful among patients who are not prototypic for a personality disorder. PMID:24288580

sec-Butylpropylacetamide (SPD) has antimigraine properties

PubMed Central

Kaufmann, Dan; Bates, Emily A; Yagen, Boris; Bialer, Meir; Saunders, Gerald H; Wilcox, Karen; White, H Steve; Brennan, KC

2016-01-01

Background Though migraine is disabling and affects 12%–15% of the population, there are few drugs that have been developed specifically for migraine prevention. Valproic acid (VPA) is a broad-spectrum antiepileptic drug (AED) that is also used for migraine prophylaxis, but its clinical use is limited by its side effect profile. sec-Butylpropylacetamide (SPD) is a novel VPA derivative, designed to be more potent and tolerable than VPA, that has shown efficacy in animal seizure and pain models. Methods We evaluated SPD’s antimigraine potential in the cortical spreading depression (CSD) and nitroglycerin (NTG) models of migraine. To evaluate SPD’s mechanism of action, we performed whole-cell recordings on cultured cortical neurons and neuroblastoma cells. Results In the CSD model, the SPD-treated group showed a significantly lower median number of CSDs compared to controls. In the NTG-induced mechanical allodynia model, SPD dose-dependently reduced mechanical sensitivity compared to controls. SPD showed both a significant potentiation of GABA-mediated currents and a smaller but significant decrease in NMDA currents in cultured cortical neurons. Kainic acid-evoked currents and voltage-dependent sodium channel currents were not changed by SPD. Conclusions These results demonstrate SPD’s potential as a promising novel antimigraine compound, and suggest a GABAergic mechanism of action. PMID:26568161

Resistive switching near electrode interfaces: Estimations by a current model

NASA Astrophysics Data System (ADS)

Schroeder, Herbert; Zurhelle, Alexander; Stemmer, Stefanie; Marchewka, Astrid; Waser, Rainer

2013-02-01

The growing resistive switching database is accompanied by many detailed mechanisms which often are pure hypotheses. Some of these suggested models can be verified by checking their predictions with the benchmarks of future memory cells. The valence change memory model assumes that the different resistances in ON and OFF states are made by changing the defect density profiles in a sheet near one working electrode during switching. The resulting different READ current densities in ON and OFF states were calculated by using an appropriate simulation model with variation of several important defect and material parameters of the metal/insulator (oxide)/metal thin film stack such as defect density and its profile change in density and thickness, height of the interface barrier, dielectric permittivity, applied voltage. The results were compared to the benchmarks and some memory windows of the varied parameters can be defined: The required ON state READ current density of 105 A/cm2 can only be achieved for barriers smaller than 0.7 eV and defect densities larger than 3 × 1020 cm-3. The required current ratio between ON and OFF states of at least 10 requests defect density reduction of approximately an order of magnitude in a sheet of several nanometers near the working electrode.

Research opportunities in muscle atrophy

NASA Technical Reports Server (NTRS)

Herbison, G. J. (Editor); Talbot, J. M. (Editor)

1984-01-01

Muscle atrophy in a weightless environment is studied. Topics of investigation include physiological factors of muscle atrophy in space flight, biochemistry, countermeasures, modelling of atrophied muscle tissue, and various methods of measurement of muscle strength and endurance. A review of the current literature and suggestions for future research are included.

Secret Wisdom: Spiritual Intelligence in Adolescents

ERIC Educational Resources Information Center

Kilcup, Charmayne

2016-01-01

Current models of spiritual development suggest that adolescents have limited capacity for spirituality and spiritual experiences. Adolescents are seen to have immature moral and ethical judgment and be incapable of deep spiritual experience due to lack of cognitive development. This mixed-methods study explored the existence of spiritual…

Male More than Female Infants Imitate Propulsive Motion

ERIC Educational Resources Information Center

Benenson, Joyce F.; Tennyson, Robert; Wrangham, Richard W.

2011-01-01

Few experimental studies investigate the mechanisms by which young children develop sex-typed activity preferences. Gender self-labeling followed by selective imitation of same-sex models currently is considered a primary socialization mechanism. Research with prenatally androgenized girls and non-human primates also suggests an innate male…

An Analysis of Web Image Queries for Search.

ERIC Educational Resources Information Center

Pu, Hsiao-Tieh

2003-01-01

Examines the differences between Web image and textual queries, and attempts to develop an analytic model to investigate their implications for Web image retrieval systems. Provides results that give insight into Web image searching behavior and suggests implications for improvement of current Web image search engines. (AEF)

State Teacher Evaluation and Teacher Education

ERIC Educational Resources Information Center

Marchant, Gregory J.; David, Kristine A.; Rodgers, Deborah; German, Rachel L.

2015-01-01

Current accountability trends suggest an increasing role in state mandates regarding teacher evaluation. With various evaluation models and components serving as the basis for quality teaching, teacher education programs need to recognize the role teacher evaluation plays and incorporate aspects where appropriate. This article makes that case and…

Childhood Personality Types: Vulnerability and Adaptation over Time

ERIC Educational Resources Information Center

De Clercq, Barbara; Rettew, David; Althoff, Robert R.; De Bolle, Marleen

2012-01-01

Background: Substantial evidence suggests that a Five-Factor Model personality assessment generates a valid description of childhood individual differences and relates to a range of psychological outcomes. Less is known, however, about naturally occurring profiles of personality and their links to psychopathology. The current study explores…

Memory, Cognitive Processing, and the Process of "Listening": A Reply to Thomas and Levine.

ERIC Educational Resources Information Center

Bostrom, Robert N.

1996-01-01

Describes several "inaccurate" statements made in L. Thomas' and T. Levine's article in this journal (volume 21, page 103) regarding the current author's research and positions on the listening construct. Suggests that Thomas' and Levine's model has serious methodological flaws. (RS)

Teaching about Religion in Public Schools.

ERIC Educational Resources Information Center

Piediscalzi, Nicholas, Ed.; Collie, William E., Ed.

Sixteen articles written by various authors are contained in this book about teaching religion in public schools. Developed for both elementary and secondary programs, the articles detail current practices. Models and units of study are suggested for teaching religion in different subject areas, including language arts, humanities, and social…

Impact of current speed on mass flux to a model flexible seagrass blade

NASA Astrophysics Data System (ADS)

Lei, Jiarui; Nepf, Heidi

2016-07-01

Seagrass and other freshwater macrophytes can acquire nutrients from surrounding water through their blades. This flux may depend on the current speed (U), which can influence both the posture of flexible blades (reconfiguration) and the thickness of the flux-limiting diffusive layer. The impact of current speed (U) on mass flux to flexible blades of model seagrass was studied through a combination of laboratory flume experiments, numerical modeling and theory. Model seagrass blades were constructed from low-density polyethylene (LDPE), and 1, 2-dichlorobenzene was used as a tracer chemical. The tracer mass accumulation in the blades was measured at different unidirectional current speeds. A numerical model was used to estimate the transfer velocity (K) by fitting the measured mass uptake to a one-dimensional diffusion model. The measured transfer velocity was compared to predictions based on laminar and turbulent boundary layers developing over a flat plate parallel to flow, for which K∝U0.5 and ∝U, respectively. The degree of blade reconfiguration depended on the dimensionless Cauchy number, Ca, which is a function of both the blade stiffness and flow velocity. For large Ca, the majority of the blade was parallel to the flow, and the measured transfer velocity agreed with laminar boundary layer theory, K∝U0.5. For small Ca, the model blades remained upright, and the flux to the blade was diminished relative to the flat-plate model. A meadow-scale analysis suggests that the mass exchange at the blade scale may control the uptake at the meadow scale.

Determination of the thickness of Al2O3 barriers in magnetic tunnel junctions

NASA Astrophysics Data System (ADS)

Buchanan, J. D. R.; Hase, T. P. A.; Tanner, B. K.; Hughes, N. D.; Hicken, R. J.

2002-07-01

The barrier thickness in magnetic spin-dependent tunnel junctions with Al2O3 barriers has been measured using grazing incidence x-ray reflectivity and by fitting the tunneling current to the Simmons model. We have studied the effect of glow discharge oxidation time on the barrier structure, revealing a substantial increase in Al2O3 thickness with oxidation. The greater thickness of barrier measured using grazing incidence x-ray reflectivity compared with that obtained by fitting current density-voltage to the Simmons electron tunneling model suggests that electron tunneling is localized to specific regions across the barrier, where the thickness is reduced by fluctuations due to nonconformal roughness.

Integrating normal and abnormal personality structure: a proposal for DSM-V.

PubMed

Widiger, Thomas A

2011-06-01

The personality disorders section of the American Psychiatric Association's fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) is currently being developed. The purpose of the current paper is to encourage the authors of DSM-V to integrate normal and abnormal personality structure within a common, integrative model, and to suggest that the optimal choice for such an integration would be the five-factor model (FFM) of general personality structure. A proposal for the classification of personality disorder from the perspective of the FFM is provided. Discussed as well are implications and issues associated with an FFM of personality disorder, including validity, coverage, feasibility, clinical utility, and treatment implications.

Modelling of illuminated current-voltage characteristics to evaluate leakage currents in long wavelength infrared mercury cadmium telluride photovoltaic detectors

NASA Astrophysics Data System (ADS)

Gopal, Vishnu; Qiu, WeiCheng; Hu, Weida

2014-11-01

The current-voltage characteristics of long wavelength mercury cadmium telluride infrared detectors have been studied using a recently suggested method for modelling of illuminated photovoltaic detectors. Diodes fabricated on in-house grown arsenic and vacancy doped epitaxial layers were evaluated for their leakage currents. The thermal diffusion, generation-recombination (g-r), and ohmic currents were found as principal components of diode current besides a component of photocurrent due to illumination. In addition, both types of diodes exhibited an excess current component whose growth with the applied bias voltage did not match the expected growth of trap-assisted-tunnelling current. Instead, it was found to be the best described by an exponential function of the type, Iexcess = Ir0 + K1 exp (K2 V), where Ir0, K1, and K2 are fitting parameters and V is the applied bias voltage. A study of the temperature dependence of the diode current components and the excess current provided the useful clues about the source of origin of excess current. It was found that the excess current in diodes fabricated on arsenic doped epitaxial layers has its origin in the source of ohmic shunt currents. Whereas, the source of excess current in diodes fabricated on vacancy doped epitaxial layers appeared to be the avalanche multiplication of photocurrent. The difference in the behaviour of two types of diodes has been attributed to the difference in the quality of epitaxial layers.

The Mechanism of Functional Up-Regulation of P2X3 Receptors of Trigeminal Sensory Neurons in a Genetic Mouse Model of Familial Hemiplegic Migraine Type 1 (FHM-1)

PubMed Central

Hullugundi, Swathi K.; Ferrari, Michel D.; van den Maagdenberg, Arn M. J. M.; Nistri, Andrea

2013-01-01

A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors of sensory neurons that convey nociceptive signals to the brainstem. Why P2X3 receptors are constitutively more responsive, however, remains unclear as their membrane expression and TRPV1 nociceptor activity are the same as in wildtype (WT) neurons. Using primary cultures of WT or KI trigeminal ganglia, we investigated whether soluble compounds that may contribute to initiating (or maintaining) migraine attacks, such as TNFα, CGRP, and BDNF, might be responsible for increasing P2X3 receptor responses. Exogenous application of TNFα potentiated P2X3 receptor-mediated currents of WT but not of KI neurons, most of which expressed both the P2X3 receptor and the TNFα receptor TNFR2. However, sustained TNFα neutralization failed to change WT or KI P2X3 receptor currents. This suggests that endogenous TNFα does not regulate P2X3 receptor responses. Nonetheless, on cultures made from both genotypes, exogenous TNFα enhanced TRPV1 receptor-mediated currents expressed by a few neurons, suggesting transient amplification of TRPV1 nociceptor responses. CGRP increased P2X3 receptor currents only in WT cultures, although prolonged CGRP receptor antagonism or BDNF neutralization reduced KI currents to WT levels. Our data suggest that, in KI trigeminal ganglion cultures, constitutive up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP and BDNF levels, thereby rendering these neurons more responsive to extracellular ATP. PMID:23577145

Australian Aboriginal Geomythology: Eyewitness Accounts of Cosmic Impacts?

NASA Astrophysics Data System (ADS)

Hamacher, Duane W.; Norris, Ray P.

2009-12-01

Descriptions of cosmic impacts and meteorite falls are found throughout Australian Aboriginal oral traditions. In some cases, these texts describe the impact event in detail, sometimes citing the location, suggesting that the events were witnessed. We explore whether cosmic impacts and meteorite falls may have been witnessed by Aboriginal Australians and incorporated into their oral traditions. We discuss the complications and bias in recording and analysing oral texts but suggest that these texts may be used both to locate new impact structures or meteorites and model observed impact events. We find that, while detailed Aboriginal descriptions of cosmic impacts are abundant in the literature, there is currently no physical evidence connecting these accounts to impact events currently known to Western science.

Studies on Methanol Crossover in Liquid-Feed Direct Methanol Pem Fuel Cells

NASA Technical Reports Server (NTRS)

Narayanan, S. R.

1995-01-01

The performance of liquid feed direct methanol fuel cells using various types of Nafion membranes as the solid polymer electrolyte have been studied. The rate of fuel crossover and electrical performance has been measured for cells with Nafion membranes of various thicknesses and equivalent weights. The crossover rate is found to decrease with increasing thickness and applied current. The dependence of crossover rate on current density can be understood in terms of a simple linear diffusion model which suggests that the crossover rate can be influenced by the electrode structure in addition to the membrane. The studies suggest that Nafion EW 1500 is a very promising alternate to Nafion EW 1100 for direct methanol fuel cells.

Soil salinity decreases global soil organic carbon stocks.

PubMed

Setia, Raj; Gottschalk, Pia; Smith, Pete; Marschner, Petra; Baldock, Jeff; Setia, Deepika; Smith, Jo

2013-11-01

Saline soils cover 3.1% (397 million hectare) of the total land area of the world. The stock of soil organic carbon (SOC) reflects the balance between carbon (C) inputs from plants, and losses through decomposition, leaching and erosion. Soil salinity decreases plant productivity and hence C inputs to the soil, but also microbial activity and therefore SOC decomposition rates. Using a modified Rothamsted Carbon model (RothC) with a newly introduced salinity decomposition rate modifier and a plant input modifier we estimate that, historically, world soils that are currently saline have lost an average of 3.47 tSOC ha(-1) since they became saline. With the extent of saline soils predicted to increase in the future, our modelling suggests that world soils may lose 6.8 Pg SOC due to salinity by the year 2100. Our findings suggest that current models overestimate future global SOC stocks and underestimate net CO2 emissions from the soil-plant system by not taking salinity effects into account. From the perspective of enhancing soil C stocks, however, given the lower SOC decomposition rate in saline soils, salt tolerant plants could be used to sequester C in salt-affected areas. Copyright © 2012 Elsevier B.V. All rights reserved.

Double layers and circuits in astrophysics

NASA Technical Reports Server (NTRS)

Alfven, Hannes

1986-01-01

As the rate of energy release in a double layer with voltage delta V is P approx I delta V, a double layer must be treated as a part of a circuit which delivers the current I. As neither double layer nor circuit can be derived from magnetofluid models of a plasma, such models are useless for treating energy transfer by means of double layers. They must be replaced by particle models and circuit theory. A simple circuit is suggested which is applied to the energizing of auroral particles, to solar flares, and to intergalactic double radio sources. Application to the heliospheric current systems leads to the prediction of two double layers on the Sun's axis which may give radiations detectable from Earth. Double layers in space should be classified as a new type of celestial object (one example is the double radio sources). It is tentatively suggested in X-ray and Gamma-ray bursts may be due to exploding double layers (although annihilation is an alternative energy source). A study of how a number of the most used textbooks in astrophysics treat important concepts like double layers, critical velocity, pinch effects and circuits is made.

Ion transport and loss in the earth's quiet ring current. I - Data and standard model

NASA Technical Reports Server (NTRS)

Sheldon, R. B.; Hamilton, D. C.

1993-01-01

A study of the transport and loss of ions in the earth's quiet time ring current, in which the standard radial diffusion model developed for the high-energy radiation belt particles is compared with the measurements of the lower-energy ring current ions, is presented. The data set provides ionic composition information in an energy range that includes the bulk of the ring current energy density, 1-300 keV/e. Protons are found to dominate the quiet time energy density at all altitudes, peaking near L of about 4 at 60 keV/cu cm, with much smaller contributions from O(+) (1-10 percent), He(+) (1-5 percent), and He(2+) (less than 1 percent). A minimization procedure is used to fit the amplitudes of the standard electric radial diffusion coefficient, yielding 5.8 x 10 exp -11 R(E-squared)/s. Fluctuation ionospheric electric fields are suggested as the source of the additional diffusion detected.

PTSD's latent structure in Malaysian tsunami victims: assessing the newly proposed Dysphoric Arousal model.

PubMed

Armour, Cherie; Raudzah Ghazali, Siti; Elklit, Ask

2013-03-30

The underlying latent structure of Posttraumatic Stress Disorder (PTSD) is widely researched. However, despite a plethora of factor analytic studies, no single model has consistently been shown as superior to alternative models. The two most often supported models are the Emotional Numbing and the Dysphoria models. However, a recently proposed five-factor Dysphoric Arousal model has been gathering support over and above existing models. Data for the current study were gathered from Malaysian Tsunami survivors (N=250). Three competing models (Emotional Numbing/Dysphoria/Dysphoric Arousal) were specified and estimated using Confirmatory Factor Analysis (CFA). The Dysphoria model provided superior fit to the data compared to the Emotional Numbing model. However, using chi-square difference tests, the Dysphoric Arousal model showed a superior fit compared to both the Emotional Numbing and Dysphoria models. In conclusion, the current results suggest that the Dysphoric Arousal model better represents PTSD's latent structure and that items measuring sleeping difficulties, irritability/anger and concentration difficulties form a separate, unique PTSD factor. These results are discussed in relation to the role of Hyperarousal in PTSD's on-going symptom maintenance and in relation to the DSM-5. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Trap densities and transport properties of pentacene metal-oxide-semiconductor transistors. I. Analytical modeling of time-dependent characteristics

NASA Astrophysics Data System (ADS)

Basile, A. F.; Cramer, T.; Kyndiah, A.; Biscarini, F.; Fraboni, B.

2014-06-01

Metal-oxide-semiconductor (MOS) transistors fabricated with pentacene thin films were characterized by temperature-dependent current-voltage (I-V) characteristics, time-dependent current measurements, and admittance spectroscopy. The channel mobility shows almost linear variation with temperature, suggesting that only shallow traps are present in the semiconductor and at the oxide/semiconductor interface. The admittance spectra feature a broad peak, which can be modeled as the sum of a continuous distribution of relaxation times. The activation energy of this peak is comparable to the polaron binding energy in pentacene. The absence of trap signals in the admittance spectra confirmed that both the semiconductor and the oxide/semiconductor interface have negligible density of deep traps, likely owing to the passivation of SiO2 before pentacene growth. Nevertheless, current instabilities were observed in time-dependent current measurements following the application of gate-voltage pulses. The corresponding activation energy matches the energy of a hole trap in SiO2. We show that hole trapping in the oxide can explain both the temperature and the time dependences of the current instabilities observed in pentacene MOS transistors. The combination of these experimental techniques allows us to derive a comprehensive model for charge transport in hybrid architectures where trapping processes occur at various time and length scales.

Personalized query suggestion based on user behavior

NASA Astrophysics Data System (ADS)

Chen, Wanyu; Hao, Zepeng; Shao, Taihua; Chen, Honghui

Query suggestions help users refine their queries after they input an initial query. Previous work mainly concentrated on similarity-based and context-based query suggestion approaches. However, models that focus on adapting to a specific user (personalization) can help to improve the probability of the user being satisfied. In this paper, we propose a personalized query suggestion model based on users’ search behavior (UB model), where we inject relevance between queries and users’ search behavior into a basic probabilistic model. For the relevance between queries, we consider their semantical similarity and co-occurrence which indicates the behavior information from other users in web search. Regarding the current user’s preference to a query, we combine the user’s short-term and long-term search behavior in a linear fashion and deal with the data sparse problem with Bayesian probabilistic matrix factorization (BPMF). In particular, we also investigate the impact of different personalization strategies (the combination of the user’s short-term and long-term search behavior) on the performance of query suggestion reranking. We quantify the improvement of our proposed UB model against a state-of-the-art baseline using the public AOL query logs and show that it beats the baseline in terms of metrics used in query suggestion reranking. The experimental results show that: (i) for personalized ranking, users’ behavioral information helps to improve query suggestion effectiveness; and (ii) given a query, merging information inferred from the short-term and long-term search behavior of a particular user can result in a better performance than both plain approaches.

A bottom-up evolution of terrestrial ecosystem modeling theory, and ideas toward global vegetation modeling

NASA Technical Reports Server (NTRS)

Running, Steven W.

1992-01-01

A primary purpose of this review is to convey lessons learned in the development of a forest ecosystem modeling approach, from it origins in 1973 as a single-tree water balance model to the current regional applications. The second intent is to use this accumulated experience to offer ideas of how terrestrial ecosystem modeling can be taken to the global scale: earth systems modeling. A logic is suggested where mechanistic ecosystem models are not themselves operated globally, but rather are used to 'calibrate' much simplified models, primarily driven by remote sensing, that could be implemented in a semiautomated way globally, and in principle could interface with atmospheric general circulation models (GCM's).

Electrochemical current noise on aluminum microelectrodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isaac, J.W.; Hebert, K.R.

1999-02-01

Aluminum disk microelectrodes were used to investigate electrochemical current noise in pH 8.8 borate buffer. The current noise spectra, expressed in terms of the current spectral density, had a characteristic two-plateau structure in the experimental bandwidth of 0.05--50 Hz, were potential-independent, and increased proportionally to electrode area. Injection of NaCl solution near the electrode surface, at potentials below that of the onset of pitting corrosion, caused 0.1--1 Hz current fluctuations to appear. From the frequency and area dependence of the current spectral density in the chloride-free solution, it was concluded that the noise arose from a number of discrete, approximatelymore » evenly distributed voltage noise sources positioned electrically in series with the inner barrier layer of the oxide film. A mathematical model for the current noise was developed which described a physical mechanism for noise production based on fluctuations in the widths of cracks or pores in the outer part of the surface film. The model was consistent with the observed area and frequency dependence of the current spectral density, suggesting that the physical process it described is a possible mechanism of noise generation. It could not be determined whether the noise sources were isolated defects or flaws, or pores in an outer precipitated portion of the oxide film.« less

Survey of air cargo forecasting techniques

NASA Technical Reports Server (NTRS)

Kuhlthan, A. R.; Vermuri, R. S.

1978-01-01

Forecasting techniques currently in use in estimating or predicting the demand for air cargo in various markets are discussed with emphasis on the fundamentals of the different forecasting approaches. References to specific studies are cited when appropriate. The effectiveness of current methods is evaluated and several prospects for future activities or approaches are suggested. Appendices contain summary type analyses of about 50 specific publications on forecasting, and selected bibliographies on air cargo forecasting, air passenger demand forecasting, and general demand and modalsplit modeling.

Engineering photorespiration: current state and future possibilities.

PubMed

Peterhansel, C; Krause, K; Braun, H-P; Espie, G S; Fernie, A R; Hanson, D T; Keech, O; Maurino, V G; Mielewczik, M; Sage, R F

2013-07-01

Reduction of flux through photorespiration has been viewed as a major way to improve crop carbon fixation and yield since the energy-consuming reactions associated with this pathway were discovered. This view has been supported by the biomasses increases observed in model species that expressed artificial bypass reactions to photorespiration. Here, we present an overview about the major current attempts to reduce photorespiratory losses in crop species and provide suggestions for future research priorities. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

The Impact of Accelerating Faster than Exponential Population Growth on Genetic Variation

PubMed Central

Reppell, Mark; Boehnke, Michael; Zöllner, Sebastian

2014-01-01

Current human sequencing projects observe an abundance of extremely rare genetic variation, suggesting recent acceleration of population growth. To better understand the impact of such accelerating growth on the quantity and nature of genetic variation, we present a new class of models capable of incorporating faster than exponential growth in a coalescent framework. Our work shows that such accelerated growth affects only the population size in the recent past and thus large samples are required to detect the models’ effects on patterns of variation. When we compare models with fixed initial growth rate, models with accelerating growth achieve very large current population sizes and large samples from these populations contain more variation than samples from populations with constant growth. This increase is driven almost entirely by an increase in singleton variation. Moreover, linkage disequilibrium decays faster in populations with accelerating growth. When we instead condition on current population size, models with accelerating growth result in less overall variation and slower linkage disequilibrium decay compared to models with exponential growth. We also find that pairwise linkage disequilibrium of very rare variants contains information about growth rates in the recent past. Finally, we demonstrate that models of accelerating growth may substantially change estimates of present-day effective population sizes and growth times. PMID:24381333

The use of music therapy within the SCERTS model for children with Autism Spectrum Disorder.

PubMed

Walworth, Darcy DeLoach

2007-01-01

The SCERTS model is a new, comprehensive curriculum designed to assess and identify treatment goals and objectives within a multidisciplinary team of clinicians and educators for children with Autism Spectrum Disorders (ASD). This model is an ongoing assessment tool with resulting goals and objectives derived there from. Because music therapy offers a unique interaction setting for children with ASD to elicit communication skills, music therapists will need to be an integral part of the multidisciplinary assessment team using the SCERTS model which is projected to become the primary nation wide curriculum for children with ASD. The purpose of this paper is to assist music therapists in transitioning to this model by providing an overview and explanation of the SCERTS model and by identifying how music therapists are currently providing clinical services incorporated in the SCERTS Model for children with ASD. In order to formulate comprehensive transitional suggestions, a national survey of music therapists working with clients at risk or diagnosed with ASD was conducted to: (a) identify the areas of SCERTS assessment model that music therapists are currently addressing within their written goals for clients with ASD, (b) identify current music therapy activities that address various SCERTS goals and objectives, and (c) provide demographic information about settings, length, and tools used in music therapy interventions for clients with ASD.

A critical review of "Internet addiction" criteria with suggestions for the future.

PubMed

Van Rooij, Antonius J; Prause, Nicole

2014-12-01

In the last 5 years a deluge of articles on the topic of Internet addiction (IA) has proposed many candidate symptoms as evidence of this proposed disease. We critically reviewed the current approach to the measurement and identification of this new excessive behavior syndrome. Three popular models of IA were discussed: Griffith’s components model; Young’s Internet Addiction Test (IAT); and the criteria by Tao et al. (2010). We selected these models because they are widely cited and propose specific criteria for IA disorder. Our approach is not meant to provide an exhaustive review, but to discuss and critique the most salient trends in the field. The models of Internet addiction share some criteria, including feeling a loss of control over Internet use; ensuing psychological, social, or professional conflict or problems; and preoccupation when not using the Internet. Other criteria inconsistently mentioned include: mood management, tolerance, withdrawal, and craving/anticipation. The models studied here share the assumption that the Internet can produce a qualitative shift to a diseased state in humans. We critically discussed the above criteria and concluded that the evidence base is currently not strong enough to provide support for an Internet addiction disorder. Future research areas are suggested: (1) Focusing on common impaired dimensions, (2) exploring neuroimaging as a model building tool, and (3) identifying shifts in the rewarding aspects of Internet use. Given the lack of consensus on the subject of Internet addiction, a focus on problem behaviors appears warranted.

Mathematical modeling of bone marrow--peripheral blood dynamics in the disease state based on current emerging paradigms, part I.

PubMed

Afenya, Evans K; Ouifki, Rachid; Camara, Baba I; Mundle, Suneel D

2016-04-01

Stemming from current emerging paradigms related to the cancer stem cell hypothesis, an existing mathematical model is expanded and used to study cell interaction dynamics in the bone marrow and peripheral blood. The proposed mathematical model is described by a system of nonlinear differential equations with delay, to quantify the dynamics in abnormal hematopoiesis. The steady states of the model are analytically and numerically obtained. Some conditions for the local asymptotic stability of such states are investigated. Model analyses suggest that malignancy may be irreversible once it evolves from a nonmalignant state into a malignant one and no intervention takes place. This leads to the proposition that a great deal of emphasis be placed on cancer prevention. Nevertheless, should malignancy arise, treatment programs for its containment or curtailment may have to include a maximum and extensive level of effort to protect normal cells from eventual destruction. Further model analyses and simulations predict that in the untreated disease state, there is an evolution towards a situation in which malignant cells dominate the entire bone marrow - peripheral blood system. Arguments are then advanced regarding requirements for quantitatively understanding cancer stem cell behavior. Among the suggested requirements are, mathematical frameworks for describing the dynamics of cancer initiation and progression, the response to treatment, the evolution of resistance, and malignancy prevention dynamics within the bone marrow - peripheral blood architecture. Copyright © 2016 Elsevier Inc. All rights reserved.

Analysis of multigrid methods on massively parallel computers: Architectural implications

NASA Technical Reports Server (NTRS)

Matheson, Lesley R.; Tarjan, Robert E.

1993-01-01

We study the potential performance of multigrid algorithms running on massively parallel computers with the intent of discovering whether presently envisioned machines will provide an efficient platform for such algorithms. We consider the domain parallel version of the standard V cycle algorithm on model problems, discretized using finite difference techniques in two and three dimensions on block structured grids of size 10(exp 6) and 10(exp 9), respectively. Our models of parallel computation were developed to reflect the computing characteristics of the current generation of massively parallel multicomputers. These models are based on an interconnection network of 256 to 16,384 message passing, 'workstation size' processors executing in an SPMD mode. The first model accomplishes interprocessor communications through a multistage permutation network. The communication cost is a logarithmic function which is similar to the costs in a variety of different topologies. The second model allows single stage communication costs only. Both models were designed with information provided by machine developers and utilize implementation derived parameters. With the medium grain parallelism of the current generation and the high fixed cost of an interprocessor communication, our analysis suggests an efficient implementation requires the machine to support the efficient transmission of long messages, (up to 1000 words) or the high initiation cost of a communication must be significantly reduced through an alternative optimization technique. Furthermore, with variable length message capability, our analysis suggests the low diameter multistage networks provide little or no advantage over a simple single stage communications network.

eSciMart: Web Platform for Scientific Software Marketplace

NASA Astrophysics Data System (ADS)

Kryukov, A. P.; Demichev, A. P.

2016-10-01

In this paper we suggest a design of a web marketplace where users of scientific application software and databases, presented in the form of web services, as well as their providers will have presence simultaneously. The model, which will be the basis for the web marketplace is close to the customer-to-customer (C2C) model, which has been successfully used, for example, on the auction sites such as eBay (ebay.com). Unlike the classical model of C2C the suggested marketplace focuses on application software in the form of web services, and standardization of API through which application software will be integrated into the web marketplace. A prototype of such a platform, entitled eSciMart, is currently being developed at SINP MSU.

Virtual expansion of the technical vision system for smart vehicles based on multi-agent cooperation model

NASA Astrophysics Data System (ADS)

Krapukhina, Nina; Senchenko, Roman; Kamenov, Nikolay

2017-12-01

Road safety and driving in dense traffic flows poses some challenges in receiving information about surrounding moving object, some of which can be in the vehicle's blind spot. This work suggests an approach to virtual monitoring of the objects in a current road scene via a system with a multitude of cooperating smart vehicles exchanging information. It also describes the intellectual agent model, and provides methods and algorithms of identifying and evaluating various characteristics of moving objects in video flow. Authors also suggest ways for integrating the information from the technical vision system into the model with further expansion of virtual monitoring for the system's objects. Implementation of this approach can help to expand the virtual field of view for a technical vision system.

Ocean salinities reveal strong global water cycle intensification during 1950 to 2000.

PubMed

Durack, Paul J; Wijffels, Susan E; Matear, Richard J

2012-04-27

Fundamental thermodynamics and climate models suggest that dry regions will become drier and wet regions will become wetter in response to warming. Efforts to detect this long-term response in sparse surface observations of rainfall and evaporation remain ambiguous. We show that ocean salinity patterns express an identifiable fingerprint of an intensifying water cycle. Our 50-year observed global surface salinity changes, combined with changes from global climate models, present robust evidence of an intensified global water cycle at a rate of 8 ± 5% per degree of surface warming. This rate is double the response projected by current-generation climate models and suggests that a substantial (16 to 24%) intensification of the global water cycle will occur in a future 2° to 3° warmer world.

Dietary patterns and asthma prevalence, incidence and control.

PubMed

Barros, R; Moreira, A; Padrão, P; Teixeira, V H; Carvalho, P; Delgado, L; Lopes, C; Severo, M; Moreira, P

2015-11-01

The increased asthma prevalence in westernized societies has been suggested to be related to environment exposures and lifestyle changes, particularly diet. We aimed to explore the association between dietary patterns and asthma prevalence, incidence and control in a nationally representative population. Data from 32,644 adults, 53% female, from the 4th Portuguese National Health Survey were analysed. Prevalence of asthma was 5.3%; 'current asthma', defined by asthma symptoms within previous year, 3.5%; 'current medicated asthma' defined by use of asthma medication within previous year, 3.0%; 'current severe asthma' defined by emergency visit because of asthma within previous year, 1.4%; and 'incident asthma', 0.2%. Dietary patterns (DP) were identified by latent trait models based on dietary intake. Unconditional logistic regression models were performed to analyse association between DP and asthma. Age, gender, education, family income, proxy reporting information, smoking, body mass index and physical activity level were analysed as confounders. Two of the five identified DP were associated with asthma: 'high fat, sugar and salt' DP (positively correlated with pastry, chocolate and sweet desserts, candies, salty snacks, chips, fruit juices, soft drinks and alcoholic beverages consumption at snacks) was associated with asthma prevalence (OR = 1.13, 95% CI = 1.03, 1.24) and current severe asthma (OR = 1.23, 95% CI = 1.03, 1.48), while 'fish, fruit and vegetables' DP (positively correlated with fish, vegetables and fruit intake at meals) was negatively associated with current (OR = 0.84, 95% CI = 0.73, 0.98), and current medicated asthma (OR = 0.84, 95% CI = 0.72, 0.98), after adjustment for confounders. Our results suggest a protective association between 'fish, vegetables and fruit' DP and current asthma and current medicated asthma, and a detrimental association between 'high fat, sugar and salt' DP and severe asthma prevalence, further supporting the rational for diet and lifestyle intervention studies in asthma based on whole dietary patterns and physical activity. © 2015 John Wiley & Sons Ltd.

The Yermak Pass Branch: A Major Pathway for the Atlantic Water North of Svalbard?

NASA Astrophysics Data System (ADS)

Koenig, Zoé; Provost, Christine; Sennéchael, Nathalie; Garric, Gilles; Gascard, Jean-Claude

2017-12-01

An upward-looking Acoustic Doppler Current Profiler deployed from July 2007 to September 2008 in the Yermak Pass, north of Svalbard, gathered velocity data from 570 m up to 90 m at a location covered by sea ice 10 months out of 12. Barotropic diurnal and semidiurnal tides are the dominant signals in the velocity (more than 70% of the velocity variance). In winter, baroclinic eddies at periods between 5 and 15 days and pulses of 1-2 month periodicity are observed in the Atlantic Water layer and are associated with a shoaling of the pycnocline. Mercator-Ocean global operational model with daily and 1/12° spatial resolution is shown to have skills in representing low-frequency velocity variations (>1 month) in the West Spitsbergen Current and in the Yermak Pass. Model outputs suggest that the Yermak Pass Branch has had a robust winter pattern over the last 10 years, carrying on average 31% of the Atlantic Water volume transport of the West Spitsbergen Current (36% in autumn/winter). However, those figures have to be considered with caution as the model neither simulates tides nor fully resolves eddies and ignores residual mean currents that could be significant.

Advanced space propulsion thruster research

NASA Technical Reports Server (NTRS)

Wilbur, P. J.

1981-01-01

Experiments showed that stray magnetic fields can adversely affect the capacity of a hollow cathode neutralizer to couple to an ion beam. Magnetic field strength at the neutralizer cathode orifice is a crucial factor influencing the coupling voltage. The effects of electrostatic accelerator grid aperture diameters on the ion current extraction capabilities were examined experimentally to describe the divergence, deflection, and current extraction capabilities of grids with the screen and accelerator apertures displaced relative to one another. Experiments performed in orificed, mercury hollow cathodes support the model of field enhanced thermionic electron mission from cathode inserts. Tests supported the validity of a thermal model of the cathode insert. A theoretical justification of a Saha equation model relating cathode plasma properties is presented. Experiments suggest that ion loss rates to discharge chamber walls can be controlled. A series of new discharge chamber magnetic field configurations were generated in the flexible magnetic field thruster and their effect on performance was examined. A technique used in the thruster to measure ion currents to discharge chamber walls is described. Using these ion currents the fraction of ions produced that are extracted from the discharge chamber and the energy cost of plasma ions are computed.

Past and future evolution of Abies alba forests in Europe - comparison of a dynamic vegetation model with palaeo data and observations.

PubMed

Ruosch, Melanie; Spahni, Renato; Joos, Fortunat; Henne, Paul D; van der Knaap, Willem O; Tinner, Willy

2016-02-01

Information on how species distributions and ecosystem services are impacted by anthropogenic climate change is important for adaptation planning. Palaeo data suggest that Abies alba formed forests under significantly warmer-than-present conditions in Europe and might be a native substitute for widespread drought-sensitive temperate and boreal tree species such as beech (Fagus sylvatica) and spruce (Picea abies) under future global warming conditions. Here, we combine pollen and macrofossil data, modern observations, and results from transient simulations with the LPX-Bern dynamic global vegetation model to assess past and future distributions of A. alba in Europe. LPX-Bern is forced with climate anomalies from a run over the past 21 000 years with the Community Earth System Model, modern climatology, and with 21st-century multimodel ensemble results for the high-emission RCP8.5 and the stringent mitigation RCP2.6 pathway. The simulated distribution for present climate encompasses the modern range of A. alba, with the model exceeding the present distribution in north-western and southern Europe. Mid-Holocene pollen data and model results agree for southern Europe, suggesting that at present, human impacts suppress the distribution in southern Europe. Pollen and model results both show range expansion starting during the Bølling-Allerød warm period, interrupted by the Younger Dryas cold, and resuming during the Holocene. The distribution of A. alba expands to the north-east in all future scenarios, whereas the potential (currently unrealized) range would be substantially reduced in southern Europe under RCP8.5. A. alba maintains its current range in central Europe despite competition by other thermophilous tree species. Our combined palaeoecological and model evidence suggest that A. alba may ensure important ecosystem services including stand and slope stability, infrastructure protection, and carbon sequestration under significantly warmer-than-present conditions in central Europe. © 2015 John Wiley & Sons Ltd.

Utilizing Peer Observation as a Professional Development Tool to Learn in Context

ERIC Educational Resources Information Center

Hirsch, Linda J.

2011-01-01

De-contextualized professional development is the common route taken by school districts to addresses pedagogical skills and address change within an educational organization. Research suggests that the current process of professional development activities is limited if not ineffective. Research shows that another model of professional…

School Reports: Creating Common Understandings.

ERIC Educational Resources Information Center

Lewis, Sharon

1998-01-01

Suggesting that creating a report for each school involved in the Reading Recovery program can have a powerful impact, this paper shows the current model of campus reports for the Spring Branch Independent School District, Houston, Texas. The report form described in the paper is continually growing and changing through need and collaboration with…

The Function of Educational Administration in the Processes of Cultural Transmission.

ERIC Educational Resources Information Center

Bates, Richard J.

A study of the implementation of a rational/bureaucratic model of knowledge in classrooms suggests that current modes of educational administration are based on control, via rational planning, of social relations, individual consciousness, and epistemology. Bureaucratic organization and professionalism enjoy a symbiotic relationship, combined with…

The Search for a More Adequate Definition of Citizenship Education.

ERIC Educational Resources Information Center

Engle, Shirley H.

The paper analyzes the multifaceted nature of current citizenship education programs and suggests a model which would reconcile the differences between conflicting program approaches. One problem of citizenship education is lack of consensus on its goals and content. Some programs emphasize socialization to established rules of social and…

An examination of fuel particle heating during fire spread

Treesearch

Jack D. Cohen; Mark A. Finney

2010-01-01

Recent high intensity wildfires and our demonstrated inability to control extreme fire behavior suggest a need for alternative approaches for preventing wildfire disasters. Current fire spread models are not sufficiently based on a basic understanding of fire spread processes to provide more effective management alternatives. An experimental and theoretical approach...

AUTOMATED GEOSPATIAL WATERSHED ASSESSMENT (AGWA): A GIS-BASED HYDROLOGIC MODELING TOOL FOR LANDSCAPE ASSESSMENT AND WATERSHED MANAGEMENT

EPA Science Inventory

The assessment of land use and land cover is an extremely important activity for contemporary land management. A large body of current literature suggests that human land-use practice is the most important factor influencing natural resource management and environmental condition...

Beyond Computer Planning: Managing Educational Computer Innovations.

ERIC Educational Resources Information Center

Washington, Wenifort

The vast underutilization of technology in educational environments suggests the need for more research to develop models to successfully adopt and diffuse computer systems in schools. Of 980 surveys mailed to various Ohio public schools, 529 were completed and returned to help determine current attitudes and perceptions of teachers and…

The Influence of Argumentativeness and Verbal Aggressiveness in Intrafamily Violence.

ERIC Educational Resources Information Center

Rancer, Andrew S.; Niemasz, JoAnn

In order to identify causes of spousal abuse, current research efforts have attempted to reconstruct the communicative components of physically aggressive encounters within the family. An interactionist model of intrafamily violence, proposed by D. A. Infante, suggests that the interaction of personal, situational, and societal conditions may lead…

Defining a Tri-Dimensional Role for Leadership in Further Education Colleges

ERIC Educational Resources Information Center

Lambert, Steve

2013-01-01

This article presents a review of current leadership practices of principals in further education colleges and suggests that principalship is more than a two-dimensional functional model comprising internal or externally focused activities. During the past 20 years further education leadership has become more demanding, with greater accountability…

Chronic Pain and Depression: Does the Evidence Support a Relationship?

ERIC Educational Resources Information Center

Romano, Joan M.; Turner, Judith A.

1985-01-01

A critical evaluation of the relevant literature provides some support for an association between depression and chronic pain. Common conceptual and methodological problems are discussed. Current biological and psychological models of the mechanisms by which the two syndromes may interact are summarized, and suggestions are made for future…

A Plea for Virtue in Ethics

ERIC Educational Resources Information Center

Sisti, Dominic A.; Baum-Baicker, Cynthia

2012-01-01

This article represents comments on the original article, "Nonrational processes in ethical decision making" by M. D. Rogerson et al (EJ945176). The current authors suggest that Rogerson, Gottlieb, Handelsman, Knapp, and Younggren (October 2011) presumed that the only ethical theories available for grounding decision-making models are of the…

A Proposed Conceptual Model to Measure Unwarranted Practice Variation

DTIC Science & Technology

2007-05-03

its design. The AMEDD should be proud of its long history of clinical, educational, and technological innovation in the field of medicine. Its current...estimate or any other aspect of this collection ofinformation , including suggestions for reducing the burden, to Department of Defense. Washington...Strategy.................................................................. 11 Role of the Researcher

Introductory Programming Subject in European Higher Education

ERIC Educational Resources Information Center

Aleksic, Veljko; Ivanovic, Mirjana

2016-01-01

Programming is one of the basic subjects in most informatics, computer science mathematics and technical faculties' curricula. Integrated overview of the models for teaching programming, problems in teaching and suggested solutions were presented in this paper. Research covered current state of 1019 programming subjects in 715 study programmes at…

Organizational Multiculturalism: Towards a Model of Diversity Sensitivity in the Teaching of Organizational Communication.

ERIC Educational Resources Information Center

Foeman, Anita

Too often African American students in communication courses are confronted with communication principles which to them seem inappropriate, unrealistic, and simply false. Current conceptualizations of organizational communication suggest that the organization consists of one culture (often depicted as predominantly white and predominantly male).…

Relationships Between Marijuana Dependence and Condom Use Intentions and Behavior Among Justice-Involved Adolescents

PubMed Central

Caldwell Hooper, Ann E.; Thayer, Rachel E.; Magnan, Renee E.; Bryan, Angela D.

2013-01-01

The current study examined the relationships among marijuana dependence, a theoretical model of condom use intentions, and subsequent condom use behavior in justice-involved adolescents. Participants completed baseline measures of prior sexual and substance use behavior. Of the original 720 participants, 649 (90.13 %) completed follow-up measures 6 months later. There were high levels of marijuana use (58.7 % met criteria for dependence) and risky sexual behavior among participants. Baseline model constructs were associated with condom use intentions, and intentions were a significant predictor of condom use at follow-up. Marijuana dependence did not significantly influence the relationships between model constructs, nor did it moderate the relationship of model constructs with subsequent condom use. Findings suggest that the theoretical model of condom use intentions is equally valid regardless of marijuana dependence status, suggesting that interventions to reduce sexual risk behavior among both marijuana dependent and non-dependent justice-involved adolescents can be appropriately based on the model. PMID:23370834

Working memory, situation models, and synesthesia

DOE PAGES

Radvansky, Gabriel A.; Gibson, Bradley S.; McNerney, M. Windy

2013-03-04

Research on language comprehension suggests a strong relationship between working memory span measures and language comprehension. However, there is also evidence that this relationship weakens at higher levels of comprehension, such as the situation model level. The current study explored this relationship by comparing 10 grapheme–color synesthetes who have additional color experiences when they read words that begin with different letters and 48 normal controls on a number of tests of complex working memory capacity and processing at the situation model level. On all tests of working memory capacity, the synesthetes outperformed the controls. Importantly, there was no carryover benefitmore » for the synesthetes for processing at the situation model level. This reinforces the idea that although some aspects of language comprehension are related to working memory span scores, this applies less directly to situation model levels. As a result, this suggests that theories of working memory must take into account this limitation, and the working memory processes that are involved in situation model construction and processing must be derived.« less

Working memory, situation models, and synesthesia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radvansky, Gabriel A.; Gibson, Bradley S.; McNerney, M. Windy

Research on language comprehension suggests a strong relationship between working memory span measures and language comprehension. However, there is also evidence that this relationship weakens at higher levels of comprehension, such as the situation model level. The current study explored this relationship by comparing 10 grapheme–color synesthetes who have additional color experiences when they read words that begin with different letters and 48 normal controls on a number of tests of complex working memory capacity and processing at the situation model level. On all tests of working memory capacity, the synesthetes outperformed the controls. Importantly, there was no carryover benefitmore » for the synesthetes for processing at the situation model level. This reinforces the idea that although some aspects of language comprehension are related to working memory span scores, this applies less directly to situation model levels. As a result, this suggests that theories of working memory must take into account this limitation, and the working memory processes that are involved in situation model construction and processing must be derived.« less

Light Absorption Enhancement of Black Carbon Aerosol Constrained by Particle Morphology.

PubMed

Wu, Yu; Cheng, Tianhai; Liu, Dantong; Allan, James D; Zheng, Lijuan; Chen, Hao

2018-06-19

The radiative forcing of black carbon aerosol (BC) is one of the largest sources of uncertainty in climate change assessments. Contrasting results of BC absorption enhancement ( E abs ) after aging are estimated by field measurements and modeling studies, causing ambiguous parametrizations of BC solar absorption in climate models. Here we quantify E abs using a theoretical model parametrized by the complex particle morphology of BC in different aging scales. We show that E abs continuously increases with aging and stabilizes with a maximum of ∼3.5, suggesting that previous seemingly contrast results of E abs can be explicitly described by BC aging with corresponding particle morphology. We also report that current climate models using Mie Core-Shell model may overestimate E abs at a certain aging stage with a rapid rise of E abs , which is commonly observed in the ambient. A correction coefficient for this overestimation is suggested to improve model predictions of BC climate impact.

Automated verbal credibility assessment of intentions: The model statement technique and predictive modeling

PubMed Central

van der Toolen, Yaloe; Vrij, Aldert; Arntz, Arnoud; Verschuere, Bruno

2018-01-01

Summary Recently, verbal credibility assessment has been extended to the detection of deceptive intentions, the use of a model statement, and predictive modeling. The current investigation combines these 3 elements to detect deceptive intentions on a large scale. Participants read a model statement and wrote a truthful or deceptive statement about their planned weekend activities (Experiment 1). With the use of linguistic features for machine learning, more than 80% of the participants were classified correctly. Exploratory analyses suggested that liars included more person and location references than truth‐tellers. Experiment 2 examined whether these findings replicated on independent‐sample data. The classification accuracies remained well above chance level but dropped to 63%. Experiment 2 corroborated the finding that liars' statements are richer in location and person references than truth‐tellers' statements. Together, these findings suggest that liars may over‐prepare their statements. Predictive modeling shows promise as an automated veracity assessment approach but needs validation on independent data. PMID:29861544

Opportunities for the replacement of animals in the study of nausea and vomiting

PubMed Central

Holmes, AM; Rudd, JA; Tattersall, FD; Aziz, Q; Andrews, PLR

2009-01-01

Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments. Developing novel anti-emetics and identifying emetic liability in novel chemical entities rely on models that can recreate the complexity of these multi-system reflexes. Animal models (especially the ferret and dog) are the current gold standard; however, the selection of appropriate models is still a matter of debate, especially when studying the subjective human sensation of nausea. Furthermore, these studies are associated with animal suffering. Here, following a recent workshop held to review the utility of animal models in nausea and vomiting research, we discuss the limitations of some of the current models in the context of basic research, anti-emetic development and emetic liability detection. We provide suggestions for how these limitations may be overcome using non-animal alternatives, including greater use of human volunteers, in silico and in vitro techniques and lower organisms. PMID:19371333

Exploring reconnection, current sheets, and dissipation in a laboratory MHD turbulence experiment

NASA Astrophysics Data System (ADS)

Schaffner, D. A.

2015-12-01

The Swarthmore Spheromak Experiment (SSX) can serve as a testbed for studying MHD turbulence in a controllable laboratory setting, and in particular, explore the phenomena of reconnection, current sheets and dissipation in MHD turbulence. Plasma with turbulently fluctuating magnetic and velocity fields can be generated using a plasma gun source and launched into a flux-conserving cylindrical tunnel. No background magnetic field is applied so internal fields are allowed to evolve dynamically. Point measurements of magnetic and velocity fluctuations yield broadband power-law spectra with a steepening breakpoint indicative of the onset of a dissipation scale. The frequency range at which this steepening occurs can be correlated to the ion inertial scale of the plasma, a length which is characteristic of the size of current sheets in MHD plasmas and suggests a connection to dissipation. Observation of non-Gaussian intermittent jumps in magnetic field magnitude and angle along with measurements of ion temperature bursts suggests the presence of current sheets embedded within the turbulent plasma, and possibly even active reconnection sites. Additionally, structure function analysis coupled with appeals to fractal scaling models support the hypothesis that current sheets are associated with dissipation in this system.

A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors.

PubMed

Singh, Sardar Shamshair; Sarma, Jagarlapudi A R P; Narasu, Lakshmi; Dayam, Raveendra; Xu, Shili; Neamati, Nouri

2014-01-01

A tremendous research on Poly (ADP-ribose) polymerase (PARP) pertaining to cancer and ischemia is in very rapid progress. PARP's are a specific class of enzymes that repairs the damaged DNA. Recent findings suggest also that PARP-1 is the most abundantly expressed nuclear enzyme which involves in various therapeutic areas like inflammation, stroke, cardiac ischemia, cancer and diabetes. The current review describes the overview on clinical candidates of PARP1 and its current status in clinical trials. This paper also covers identification of potent PARP1 inhibitors using structure and ligand based pharmacophore models. Finally 36 potential hits were identified from the virtual screening of pharmacophore models and screened for PARP1 activity. 15 actives were identified as potent PARP1 inhibitors and further optimization of these analogues are in progress.

Past, present and future distributions of an Iberian Endemic, Lepus granatensis: ecological and evolutionary clues from species distribution models.

PubMed

Acevedo, Pelayo; Melo-Ferreira, José; Real, Raimundo; Alves, Paulo Célio

2012-01-01

The application of species distribution models (SDMs) in ecology and conservation biology is increasing and assuming an important role, mainly because they can be used to hindcast past and predict current and future species distributions. However, the accuracy of SDMs depends on the quality of the data and on appropriate theoretical frameworks. In this study, comprehensive data on the current distribution of the Iberian hare (Lepus granatensis) were used to i) determine the species' ecogeographical constraints, ii) hindcast a climatic model for the last glacial maximum (LGM), relating it to inferences derived from molecular studies, and iii) calibrate a model to assess the species future distribution trends (up to 2080). Our results showed that the climatic factor (in its pure effect and when it is combined with the land-cover factor) is the most important descriptor of the current distribution of the Iberian hare. In addition, the model's output was a reliable index of the local probability of species occurrence, which is a valuable tool to guide species management decisions and conservation planning. Climatic potential obtained for the LGM was combined with molecular data and the results suggest that several glacial refugia may have existed for the species within the major Iberian refugium. Finally, a high probability of occurrence of the Iberian hare in the current species range and a northward expansion were predicted for future. Given its current environmental envelope and evolutionary history, we discuss the macroecology of the Iberian hare and its sensitivity to climate change.

Ultrafast probing of magnetic field growth inside a laser-driven solenoid

NASA Astrophysics Data System (ADS)

Goyon, C.; Pollock, B. B.; Turnbull, D. P.; Hazi, A.; Divol, L.; Farmer, W. A.; Haberberger, D.; Javedani, J.; Johnson, A. J.; Kemp, A.; Levy, M. C.; Grant Logan, B.; Mariscal, D. A.; Landen, O. L.; Patankar, S.; Ross, J. S.; Rubenchik, A. M.; Swadling, G. F.; Williams, G. J.; Fujioka, S.; Law, K. F. F.; Moody, J. D.

2017-03-01

We report on the detection of the time-dependent B-field amplitude and topology in a laser-driven solenoid. The B-field inferred from both proton deflectometry and Faraday rotation ramps up linearly in time reaching 210 ± 35 T at the end of a 0.75-ns laser drive with 1 TW at 351 nm. A lumped-element circuit model agrees well with the linear rise and suggests that the blow-off plasma screens the field between the plates leading to an increased plate capacitance that converts the laser-generated hot-electron current into a voltage source that drives current through the solenoid. ALE3D modeling shows that target disassembly and current diffusion may limit the B-field increase for longer laser drive. Scaling of these experimental results to a National Ignition Facility (NIF) hohlraum target size (˜0.2 cm3 ) indicates that it is possible to achieve several tens of Tesla.

Ultrafast probing of magnetic field growth inside a laser-driven solenoid.

PubMed

Goyon, C; Pollock, B B; Turnbull, D P; Hazi, A; Divol, L; Farmer, W A; Haberberger, D; Javedani, J; Johnson, A J; Kemp, A; Levy, M C; Grant Logan, B; Mariscal, D A; Landen, O L; Patankar, S; Ross, J S; Rubenchik, A M; Swadling, G F; Williams, G J; Fujioka, S; Law, K F F; Moody, J D

2017-03-01

We report on the detection of the time-dependent B-field amplitude and topology in a laser-driven solenoid. The B-field inferred from both proton deflectometry and Faraday rotation ramps up linearly in time reaching 210 ± 35 T at the end of a 0.75-ns laser drive with 1 TW at 351 nm. A lumped-element circuit model agrees well with the linear rise and suggests that the blow-off plasma screens the field between the plates leading to an increased plate capacitance that converts the laser-generated hot-electron current into a voltage source that drives current through the solenoid. ALE3D modeling shows that target disassembly and current diffusion may limit the B-field increase for longer laser drive. Scaling of these experimental results to a National Ignition Facility (NIF) hohlraum target size (∼0.2cm^{3}) indicates that it is possible to achieve several tens of Tesla.

Oceanic circulation models help to predict global biogeography of pelagic yellow-bellied sea snake

PubMed Central

Cotté, Cédric; Bailleul, Frédéric; Lalire, Maxime; Gaspar, Philippe

2016-01-01

It is well recognized that most marine vertebrates, and especially tetrapods, precisely orient and actively move in apparently homogeneous oceanic environments. Here, we investigate the presumptive role of oceanic currents in biogeographic patterns observed in a secondarily marine tetrapod, the yellow-bellied sea snake (Hydrophis [Pelamis] platurus). State-of-the-art world ocean circulation models show how H. platurus, the only pelagic species of sea snake, can potentially exploit oceanic currents to disperse and maintain population mixing between localities that spread over two-thirds of the Earth's circumference. The very close association of these snakes with surface currents seems to provide a highly efficient dispersal mechanism that allowed this species to range extensively and relatively quickly well beyond the central Indo-Pacific area, the centre of origin, abundance and diversity of sea snakes. Our results further suggest that the pan-oceanic population of this species must be extraordinarily large. PMID:27555651

A double layer model for solar X-ray and microwave pulsations

NASA Technical Reports Server (NTRS)

Tapping, K. F.

1986-01-01

The wide range of wavelengths over which quasi-periodic pulsations have been observed suggests that the mechanism causing them acts upon the supply of high energy electrons driving the emission processes. A model is described which is based upon the radial shrinkage of a magnetic flux tube. The concentration of the current, along with the reduction in the number of available charge carriers, can rise to a condition where the current demand exceeds the capacity of the thermal electrons. Driven by the large inductance of the external current circuit, an instability takes place in the tube throat, resulting in the formation of a potential double layer, which then accelerates electrons and ions to MeV energies. The double layer can be unstable, collapsing and reforming repeatedly. The resulting pulsed particle beams give rise to pulsating emission which are observed at radio and X-ray wavelengths.

Finite-size effects on current correlation functions

NASA Astrophysics Data System (ADS)

Chen, Shunda; Zhang, Yong; Wang, Jiao; Zhao, Hong

2014-02-01

We study why the calculation of current correlation functions (CCFs) still suffers from finite-size effects even when the periodic boundary condition is taken. Two important one-dimensional, momentum-conserving systems are investigated as examples. Intriguingly, it is found that the state of a system recurs in the sense of microcanonical ensemble average, and such recurrence may result in oscillations in CCFs. Meanwhile, we find that the sound mode collisions induce an extra time decay in a current so that its correlation function decays faster (slower) in a smaller (larger) system. Based on these two unveiled mechanisms, a procedure for correctly evaluating the decay rate of a CCF is proposed, with which our analysis suggests that the global energy CCF decays as ˜t-2/3 in the diatomic hard-core gas model and in a manner close to ˜t-1/2 in the Fermi-Pasta-Ulam-β model.

Water in exoplanets.

PubMed

Tinetti, Giovanna; Tennyson, Jonathan; Griffith, Caitlin A; Waldmann, Ingo

2012-06-13

Exoplanets--planets orbiting around stars other than our own Sun--appear to be common. Significant research effort is now focused on the observation and characterization of exoplanet atmospheres. Species such as water vapour, methane, carbon monoxide and carbon dioxide have been observed in a handful of hot, giant, gaseous planets, but cooler, smaller planets such as Gliese 1214b are now analysable with current telescopes. Water is the key chemical dictating habitability. The current observations of water in exoplanets from both space and the ground are reviewed. Controversies surrounding the interpretation of these observations are discussed. Detailed consideration of available radiative transfer models and linelists are used to analyse these differences in interpretation. Models suggest that there is a clear need for data on the pressure broadening of water transitions by H(2) at high temperatures. The reported detections of water appear to be robust, although final confirmation will have to await the better quality observational data provided by currently planned dedicated space missions.

Modeling the Impact on HIV Incidence of Combination Prevention Strategies among Men Who Have Sex with Men in Beijing, China

PubMed Central

Lou, Jie; Blevins, Meridith; Ruan, Yuhua; Vermund, Sten H.; Tang, Sanyi; Webb, Glenn F.; Shepherd, Bryan E.; He, Xiong; Lu, Hongyan; Shao, Yiming; Qian, Han-Zhu

2014-01-01

Objective To project the HIV/AIDS epidemics among men who have sex with men (MSM) under different combinations of HIV testing and linkage to care (TLC) interventions including antiretroviral therapy (ART) in Beijing, China. Design Mathematical modeling. Methods Using a mathematical model to fit prevalence estimates from 2000–2010, we projected trends in HIV prevalence and incidence during 2011–2020 under five scenarios: (S1) current intervention levels by averaging 2000–2010 coverage; (S2) increased ART coverage with current TLC; (S3) increased TLC/ART coverage; (S4) increased condom use; and (S5) increased TLC/ART plus increased condom use. Results The basic reproduction number based upon the current level of interventions is significantly higher than 1 ( confidence interval (CI), 1.83–2.35), suggesting that the HIV epidemic will continue to increase to 2020. Compared to the 2010 prevalence of 7.8%, the projected HIV prevalence in 2020 for the five prevention scenarios will be: (S1) Current coverage: 21.4% (95% CI, 9.9–31.7%); (S2) Increased ART: 19.9% (95% CI, 9.9–28.4%); (S3) Increased TLC/ART: 14.5% (95% CI, 7.0–23.8%); (S4) Increased condom use: 13.0% (95% CI, 9.8–28.4%); and (S5) Increased TLC/ART and condom use: 8.7% (95% CI, 5.4–11.5%). HIV epidemic will continue to rise () for S1–S4 even with hyperbolic coverage in the sensitivity analysis, and is expected to decline () for S5. Conclusion Our transmission model suggests that Beijing MSM will have a rapidly rising HIV epidemic. Even enhanced levels of TLC/ART will not interrupt epidemic expansion, despite optimistic assumptions for coverage. Promoting condom use is a crucial component of combination interventions. PMID:24626165

Healing and/or breaking? The mental health implications of repeated economic insecurity.

PubMed

Watson, Barry; Osberg, Lars

2017-09-01

Current literature confirms the negative consequences of contemporaneous economic insecurity for mental health, but ignores possible implications of repeated insecurity. This paper asks how much a person's history of economic insecurity matters for psychological distress by contrasting the implications of two models. Consistent with the health capital literature, the Healing model suggests psychological distress is a stock variable affected by shocks from life events, with past events having less impact than more recent shocks. Alternatively, the Breaking Point model considers that high levels of distress represent a distinct shift in life state, which occurs if the accumulation of past life stresses exceeds some critical value. Using five cycles of Canadian National Population Health Survey data (2000-2009), we model the impact of past economic insecurity shocks on current psychological distress in a way that can distinguish between these hypotheses. In our sample of 1775 males and 1883 females aged 25 to 64, we find a robust healing effect for one-time economic insecurity shocks. For males, only a recent one-time occurrence of economic insecurity is predictive of higher current psychological distress (0.19 standard deviations). Moreover, working age adults tend to recover from past accumulated experiences of economic insecurity if they were recently economically secure. However, consistent with the Breaking Point hypothesis, males experiencing three or four cycles of recent insecurity are estimated to have a level of current psychological distress that is 0.26-0.29 standard deviations higher than those who were employed and job secure throughout the same time period. We also find, consistent with other literature, distinct gender differences - for working age females, all economic insecurity variables are statistically insignificant at conventional levels. Our results suggest that although Canadians are resilient to one-time insecurity shocks, males most vulnerable to repeated bouts suffer from elevated levels of psychological distress. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Pliocene to recent history of the Kuroshio and Tsushima Currents: a multi-proxy approach

NASA Astrophysics Data System (ADS)

Gallagher, Stephen J.; Kitamura, Akihisa; Iryu, Yasufumi; Itaki, Takuya; Koizumi, Itaru; Hoiles, Peter W.

2015-12-01

The Kuroshio Current is a major western boundary current controlled by the North Pacific Gyre. It brings warm subtropical waters from the Indo-Pacific Warm Pool to Japan exerting a major control on Asian climate. The Tsushima Current is a Kuroshio offshoot transporting warm water into the Japan Sea. Various proxies are used to determine the paleohistory of these currents. Sedimentological proxies such as reefs, bedforms, sediment source and sorting reveal paleocurrent strength and latitude. Proxies such as coral and mollusc assemblages reveal past shelfal current activity. Microfossil assemblages and organic/inorganic geochemical analyses determine paleo- sea surface temperature and salinity histories. Transportation of tropical palynomorphs and migrations of Indo-Pacific species to Japanese waters also reveal paleocurrent activity. The stratigraphic distribution of these proxies suggests the Kuroshio Current reached its present latitude (35 °N) by ~3 Ma when temperatures were 1 to 2 °C lower than present. At this time a weak Tsushima Current broke through Tsushima Strait entering the Japan Sea. Similar oceanic conditions persisted until ~2 Ma when crustal stretching deepened the Tsushima Strait allowing inflow during every interglacial. The onset of stronger interglacial/glacial cycles ~1 Ma was associated with increased North Pacific Gyre and Kuroshio Current intensity. This triggered Ryukyu Reef expansion when reefs reached their present latitude (~31 °N), thereafter the reef front advanced (~31 °N) and retreated (~25 °N) with each cycle. Foraminiferal proxy data suggests eastward deflection of the Kuroshio Current from its present path at 24 °N into the Pacific Ocean due to East Taiwan Channel restriction during the Last Glacial Maximum. Subsequently Kuroshio flow resumed its present trajectory during the Holocene. Ocean modeling and geochemical proxies show that the Kuroshio Current path may have been similar during glacials and interglacials, however the glacial mode of this current remains controversial. Paleohistorical studies form important analogues for current behavior with future climate change, however, there are insufficient studies at present in the region that may be used for this purpose. Modeling of the response of the Kuroshio Current to future global warming reveals that current velocity may increase by up to 0.3 m/sec associated with a northward migration of the Kuroshio Extension.

Adequacy of Current State Setbacks for Directional High-Volume Hydraulic Fracturing in the Marcellus, Barnett, and Niobrara Shale Plays

PubMed Central

Haley, Marsha; McCawley, Michael; Epstein, Anne C.; Arrington, Bob; Bjerke, Elizabeth Ferrell

2016-01-01

Background: There is an increasing awareness of the multiple potential pathways leading to human health risks from hydraulic fracturing. Setback distances are a legislative method to mitigate potential risks. Objectives: We attempted to determine whether legal setback distances between well-pad sites and the public are adequate in three shale plays. Methods: We reviewed geography, current statutes and regulations, evacuations, thermal modeling, air pollution studies, and vapor cloud modeling within the Marcellus, Barnett, and Niobrara Shale Plays. Discussion: The evidence suggests that presently utilized setbacks may leave the public vulnerable to explosions, radiant heat, toxic gas clouds, and air pollution from hydraulic fracturing activities. Conclusions: Our results suggest that setbacks may not be sufficient to reduce potential threats to human health in areas where hydraulic fracturing occurs. It is more likely that a combination of reasonable setbacks with controls for other sources of pollution associated with the process will be required. Citation: Haley M, McCawley M, Epstein AC, Arrington B, Bjerke EF. 2016. Adequacy of current state setbacks for directional high-volume hydraulic fracturing in the Marcellus, Barnett, and Niobrara Shale Plays. Environ Health Perspect 124:1323–1333; http://dx.doi.org/10.1289/ehp.1510547 PMID:26895553

Logit-normal mixed model for Indian Monsoon rainfall extremes

NASA Astrophysics Data System (ADS)

Dietz, L. R.; Chatterjee, S.

2014-03-01

Describing the nature and variability of Indian monsoon rainfall extremes is a topic of much debate in the current literature. We suggest the use of a generalized linear mixed model (GLMM), specifically, the logit-normal mixed model, to describe the underlying structure of this complex climatic event. Several GLMM algorithms are described and simulations are performed to vet these algorithms before applying them to the Indian precipitation data procured from the National Climatic Data Center. The logit-normal model was applied with fixed covariates of latitude, longitude, elevation, daily minimum and maximum temperatures with a random intercept by weather station. In general, the estimation methods concurred in their suggestion of a relationship between the El Niño Southern Oscillation (ENSO) and extreme rainfall variability estimates. This work provides a valuable starting point for extending GLMM to incorporate the intricate dependencies in extreme climate events.

Research Workforce Diversity: The Case of Balancing National versus International Postdocs in US Biomedical Research.

PubMed

Ghaffarzadegan, Navid; Hawley, Joshua; Desai, Anand

2014-03-01

The US government has been increasingly supporting postdoctoral training in biomedical sciences to develop the domestic research workforce. However, current trends suggest that mostly international researchers benefit from the funding, many of whom might leave the USA after training. In this paper, we describe a model used to analyse the flow of national versus international researchers into and out of postdoctoral training. We calibrate our model in the case of the USA and successfully replicate the data. We use the model to conduct simulation-based analyses of effects of different policies on the diversity of postdoctoral researchers. Our model shows that capping the duration of postdoctoral careers, a policy proposed previously, favours international postdoctoral researchers. The analysis suggests that the leverage point to help the growth of domestic research workforce is in the pregraduate education area, and many policies implemented at the postgraduate level have minimal or unintended effects on diversity.

Application of Gauss's law space-charge limited emission model in iterative particle tracking method

NASA Astrophysics Data System (ADS)

Altsybeyev, V. V.; Ponomarev, V. A.

2016-11-01

The particle tracking method with a so-called gun iteration for modeling the space charge is discussed in the following paper. We suggest to apply the emission model based on the Gauss's law for the calculation of the space charge limited current density distribution using considered method. Based on the presented emission model we have developed a numerical algorithm for this calculations. This approach allows us to perform accurate and low time consumpting numerical simulations for different vacuum sources with the curved emitting surfaces and also in the presence of additional physical effects such as bipolar flows and backscattered electrons. The results of the simulations of the cylindrical diode and diode with elliptical emitter with the use of axysimmetric coordinates are presented. The high efficiency and accuracy of the suggested approach are confirmed by the obtained results and comparisons with the analytical solutions.

Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model

NASA Astrophysics Data System (ADS)

Šarolić, A.; Živković, Z.; Reilly, J. P.

2016-06-01

The electrostimulation excitation threshold of a nerve depends on temporal and frequency parameters of the stimulus. These dependences were investigated in terms of: (1) strength-duration (SD) curve for a single monophasic rectangular pulse, and (2) frequency dependence of the excitation threshold for a continuous sinusoidal current. Experiments were performed on the single-axon measurement setup based on Lumbricus terrestris having unmyelinated nerve fibers. The simulations were performed using the well-established SENN model for a myelinated nerve. Although the unmyelinated experimental model differs from the myelinated simulation model, both refer to a single axon. Thus we hypothesized that the dependence on temporal and frequency parameters should be very similar. The comparison was made possible by normalizing each set of results to the SD time constant and the rheobase current of each model, yielding the curves that show the temporal and frequency dependencies regardless of the model differences. The results reasonably agree, suggesting that this experimental setup and method of comparison with SENN model can be used for further studies of waveform effect on nerve excitability, including unmyelinated neurons.

Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model.

PubMed

Šarolić, A; Živković, Z; Reilly, J P

2016-06-21

The electrostimulation excitation threshold of a nerve depends on temporal and frequency parameters of the stimulus. These dependences were investigated in terms of: (1) strength-duration (SD) curve for a single monophasic rectangular pulse, and (2) frequency dependence of the excitation threshold for a continuous sinusoidal current. Experiments were performed on the single-axon measurement setup based on Lumbricus terrestris having unmyelinated nerve fibers. The simulations were performed using the well-established SENN model for a myelinated nerve. Although the unmyelinated experimental model differs from the myelinated simulation model, both refer to a single axon. Thus we hypothesized that the dependence on temporal and frequency parameters should be very similar. The comparison was made possible by normalizing each set of results to the SD time constant and the rheobase current of each model, yielding the curves that show the temporal and frequency dependencies regardless of the model differences. The results reasonably agree, suggesting that this experimental setup and method of comparison with SENN model can be used for further studies of waveform effect on nerve excitability, including unmyelinated neurons.

The wind-forced response on a buoyant coastal current: Observations of the western Gulf of Maine plume

USGS Publications Warehouse

Fong, D.A.; Geyer, W.R.; Signell, R.P.

1997-01-01

The Freshwater plume in the western Gulf of Maine is being studied as part of an interdisciplinary investigation of the physical transport of a toxic alga. A field program was conducted in the springs of 1993 and 1994 to map the spatial and temporal patterns of salinity, currents and algal toxicity. The observations suggest that the plume's cross-shore structure varies markedly as a function of fluctuations in alongshore wind forcing. Consistent with Ekman drift dynamics, upwelling favorable winds spread the plume offshore, at times widening it to over 50 km in offshore extent, while downwelling favorable winds narrow the plume width to as little as 10 km. Using a simple slab model, we find qualitative agreement between the observed variations of plume width and those predicted by Ekman theory for short time scales of integration. Near surface current meters show significant correlations between cross-shore currents and alongshore wind stress, consistent with Ekman theory. Estimates of the terms in the alongshore momentum equation calculated from moored current meter arrays also indicate a dominant Ekman balance within the plume. A significant correlation between alongshore currents and winds suggests that interfacial drag may be important, although inclusion of a Raleigh drag term does not significantly improve the alongshore momentum balance.

A systematic review of transmission dynamic studies of methicillin-resistant Staphylococcus aureus in non-hospital residential facilities.

PubMed

Kwok, Kin On; Read, Jonathan M; Tang, Arthur; Chen, Hong; Riley, Steven; Kam, Kai Man

2018-04-18

Non-hospital residential facilities are important reservoirs for MRSA transmission. However, conclusions and public health implications drawn from the many mathematical models depicting nosocomial MRSA transmission may not be applicable to these settings. Therefore, we reviewed the MRSA transmission dynamics studies in defined non-hospital residential facilities to: (1) provide an overview of basic epidemiology which has been addressed; (2) identify future research direction; and (3) improve future model implementation. A review was conducted by searching related keywords in PUBMED without time restriction as well as internet searches via Google search engine. We included only articles describing the epidemiological transmission pathways of MRSA/community-associated MRSA within and between defined non-hospital residential settings. Among the 10 included articles, nursing homes (NHs) and correctional facilities (CFs) were two settings considered most frequently. Importation of colonized residents was a plausible reason for MRSA outbreaks in NHs, where MRSA was endemic without strict infection control interventions. The importance of NHs over hospitals in increasing nosocomial MRSA prevalence was highlighted. Suggested interventions in NHs included: appropriate staffing level, screening and decolonizing, and hand hygiene. On the other hand, the small population amongst inmates in CFs has no effect on MRSA community transmission. Included models ranged from system-level compartmental models to agent-based models. There was no consensus over the course of disease progression in these models, which were mainly featured with NH residents /CF inmates/ hospital patients as transmission pathways. Some parameters used by these models were outdated or unfit. Importance of NHs has been highlighted from these current studies addressing scattered aspects of MRSA epidemiology. However, the wide variety of non-hospital residential settings suggest that more work is needed before robust conclusions can be drawn. Learning from existing work for hospitals, we identified critical future research direction in this area from infection control, ecological and economic perspectives. From current model deficiencies, we suggest more transmission pathways be specified to depict MRSA transmission, and further empirical studies be stressed to support evidence-based mathematical models of MRSA in non-hospital facilities. Future models should be ready to cope with the aging population structure.

The Proposal of the Model for Developing Dispatch System for Nationwide One-Day Integrative Planning

NASA Astrophysics Data System (ADS)

Kim, Hyun Soo; Choi, Hyung Rim; Park, Byung Kwon; Jung, Jae Un; Lee, Jin Wook

The problems of dispatch planning for container truck are classified as the pickup and delivery problems, which are highly complex issues that consider various constraints in the real world. However, in case of the current situation, it is developed by the control system so that it requires the automated planning system under the view of nationwide integrative planning. Therefore, the purpose of this study is to suggest model to develop the automated dispatch system through the constraint satisfaction problem and meta-heuristic technique-based algorithm. In the further study, the practical system is developed and evaluation is performed in aspect of various results. This study suggests model to undergo the study which promoted the complexity of the problems by considering the various constraints which were not considered in the early study. However, it is suggested that it is necessary to add the study which includes the real-time monitoring function for vehicles and cargos based on the information technology.

Improved Mental Acuity Forecasting with an Individualized Quantitative Sleep Model.

PubMed

Winslow, Brent D; Nguyen, Nam; Venta, Kimberly E

2017-01-01

Sleep impairment significantly alters human brain structure and cognitive function, but available evidence suggests that adults in developed nations are sleeping less. A growing body of research has sought to use sleep to forecast cognitive performance by modeling the relationship between the two, but has generally focused on vigilance rather than other cognitive constructs affected by sleep, such as reaction time, executive function, and working memory. Previous modeling efforts have also utilized subjective, self-reported sleep durations and were restricted to laboratory environments. In the current effort, we addressed these limitations by employing wearable systems and mobile applications to gather objective sleep information, assess multi-construct cognitive performance, and model/predict changes to mental acuity. Thirty participants were recruited for participation in the study, which lasted 1 week. Using the Fitbit Charge HR and a mobile version of the automated neuropsychological assessment metric called CogGauge, we gathered a series of features and utilized the unified model of performance to predict mental acuity based on sleep records. Our results suggest that individuals poorly rate their sleep duration, supporting the need for objective sleep metrics to model circadian changes to mental acuity. Participant compliance in using the wearable throughout the week and responding to the CogGauge assessments was 80%. Specific biases were identified in temporal metrics across mobile devices and operating systems and were excluded from the mental acuity metric development. Individualized prediction of mental acuity consistently outperformed group modeling. This effort indicates the feasibility of creating an individualized, mobile assessment and prediction of mental acuity, compatible with the majority of current mobile devices.

Expertly validated models and phylogenetically-controlled analysis suggests responses to climate change are related to species traits in the order lagomorpha.

PubMed

Leach, Katie; Kelly, Ruth; Cameron, Alison; Montgomery, W Ian; Reid, Neil

2015-01-01

Climate change during the past five decades has impacted significantly on natural ecosystems, and the rate of current climate change is of great concern among conservation biologists. Species Distribution Models (SDMs) have been used widely to project changes in species' bioclimatic envelopes under future climate scenarios. Here, we aimed to advance this technique by assessing future changes in the bioclimatic envelopes of an entire mammalian order, the Lagomorpha, using a novel framework for model validation based jointly on subjective expert evaluation and objective model evaluation statistics. SDMs were built using climatic, topographical, and habitat variables for all 87 lagomorph species under past and current climate scenarios. Expert evaluation and Kappa values were used to validate past and current models and only those deemed 'modellable' within our framework were projected under future climate scenarios (58 species). Phylogenetically-controlled regressions were used to test whether species traits correlated with predicted responses to climate change. Climate change is likely to impact more than two-thirds of lagomorph species, with leporids (rabbits, hares, and jackrabbits) likely to undertake poleward shifts with little overall change in range extent, whilst pikas are likely to show extreme shifts to higher altitudes associated with marked range declines, including the likely extinction of Kozlov's Pika (Ochotona koslowi). Smaller-bodied species were more likely to exhibit range contractions and elevational increases, but showing little poleward movement, and fecund species were more likely to shift latitudinally and elevationally. Our results suggest that species traits may be important indicators of future climate change and we believe multi-species approaches, as demonstrated here, are likely to lead to more effective mitigation measures and conservation management. We strongly advocate studies minimising data gaps in our knowledge of the Order, specifically collecting more specimens for biodiversity archives and targeting data deficient geographic regions.

Towards an Ethological Animal Model of Depression? A Study on Horses

PubMed Central

Fureix, Carole; Jego, Patrick; Henry, Séverine; Lansade, Léa; Hausberger, Martine

2012-01-01

Background Recent reviews question current animal models of depression and emphasise the need for ethological models of mood disorders based on animals living under natural conditions. Domestic horses encounter chronic stress, including potential stress at work, which can induce behavioural disorders (e.g. “apathy”). Our pioneering study evaluated the potential of domestic horses in their usual environment to become an ethological model of depression by testing this models’ face validity (i.e. behavioural similarity with descriptions of human depressive states). Methodology/Principal Findings We observed the spontaneous behaviour of 59 working horses in their home environment, focusing on immobility bouts of apparent unresponsiveness when horses displayed an atypical posture (termed withdrawn hereafter), evaluated their responsiveness to their environment and their anxiety levels, and analysed cortisol levels. Twenty-four percent of the horses presented the withdrawn posture, also characterized by gaze, head and ears fixity, a profile that suggests a spontaneous expression of “behavioural despair”. When compared with control “non-withdrawn” horses from the same stable, withdrawn horses appeared more indifferent to environmental stimuli in their home environment but reacted more emotionally in more challenging situations. They exhibited lower plasma cortisol levels. Withdrawn horses all belonged to the same breed and females were over-represented. Conclusions/Significance Horse might be a useful potential candidate for an animal model of depression. Face validity of this model appeared good, and potential genetic input and high prevalence of these disorders in females add to the convergence. At a time when current animal models of depression are questioned and the need for novel models is expressed, this study suggests that novel models and biomarkers could emerge from ethological approaches in home environments. PMID:22761752

Mental models accurately predict emotion transitions.

PubMed

Thornton, Mark A; Tamir, Diana I

2017-06-06

Successful social interactions depend on people's ability to predict others' future actions and emotions. People possess many mechanisms for perceiving others' current emotional states, but how might they use this information to predict others' future states? We hypothesized that people might capitalize on an overlooked aspect of affective experience: current emotions predict future emotions. By attending to regularities in emotion transitions, perceivers might develop accurate mental models of others' emotional dynamics. People could then use these mental models of emotion transitions to predict others' future emotions from currently observable emotions. To test this hypothesis, studies 1-3 used data from three extant experience-sampling datasets to establish the actual rates of emotional transitions. We then collected three parallel datasets in which participants rated the transition likelihoods between the same set of emotions. Participants' ratings of emotion transitions predicted others' experienced transitional likelihoods with high accuracy. Study 4 demonstrated that four conceptual dimensions of mental state representation-valence, social impact, rationality, and human mind-inform participants' mental models. Study 5 used 2 million emotion reports on the Experience Project to replicate both of these findings: again people reported accurate models of emotion transitions, and these models were informed by the same four conceptual dimensions. Importantly, neither these conceptual dimensions nor holistic similarity could fully explain participants' accuracy, suggesting that their mental models contain accurate information about emotion dynamics above and beyond what might be predicted by static emotion knowledge alone.

Biophysically Based Mathematical Modeling of Interstitial Cells of Cajal Slow Wave Activity Generated from a Discrete Unitary Potential Basis

PubMed Central

Faville, R.A.; Pullan, A.J.; Sanders, K.M.; Koh, S.D.; Lloyd, C.M.; Smith, N.P.

2009-01-01

Abstract Spontaneously rhythmic pacemaker activity produced by interstitial cells of Cajal (ICC) is the result of the entrainment of unitary potential depolarizations generated at intracellular sites termed pacemaker units. In this study, we present a mathematical modeling framework that quantitatively represents the transmembrane ion flows and intracellular Ca2+ dynamics from a single ICC operating over the physiological membrane potential range. The mathematical model presented here extends our recently developed biophysically based pacemaker unit modeling framework by including mechanisms necessary for coordinating unitary potential events, such as a T-Type Ca2+ current, Vm-dependent K+ currents, and global Ca2+ diffusion. Model simulations produce spontaneously rhythmic slow wave depolarizations with an amplitude of 65 mV at a frequency of 17.4 cpm. Our model predicts that activity at the spatial scale of the pacemaker unit is fundamental for ICC slow wave generation, and Ca2+ influx from activation of the T-Type Ca2+ current is required for unitary potential entrainment. These results suggest that intracellular Ca2+ levels, particularly in the region local to the mitochondria and endoplasmic reticulum, significantly influence pacing frequency and synchronization of pacemaker unit discharge. Moreover, numerical investigations show that our ICC model is capable of qualitatively replicating a wide range of experimental observations. PMID:19527643

Numerically pricing American options under the generalized mixed fractional Brownian motion model

NASA Astrophysics Data System (ADS)

Chen, Wenting; Yan, Bowen; Lian, Guanghua; Zhang, Ying

2016-06-01

In this paper, we introduce a robust numerical method, based on the upwind scheme, for the pricing of American puts under the generalized mixed fractional Brownian motion (GMFBM) model. By using portfolio analysis and applying the Wick-Itô formula, a partial differential equation (PDE) governing the prices of vanilla options under the GMFBM is successfully derived for the first time. Based on this, we formulate the pricing of American puts under the current model as a linear complementarity problem (LCP). Unlike the classical Black-Scholes (B-S) model or the generalized B-S model discussed in Cen and Le (2011), the newly obtained LCP under the GMFBM model is difficult to be solved accurately because of the numerical instability which results from the degeneration of the governing PDE as time approaches zero. To overcome this difficulty, a numerical approach based on the upwind scheme is adopted. It is shown that the coefficient matrix of the current method is an M-matrix, which ensures its stability in the maximum-norm sense. Remarkably, we have managed to provide a sharp theoretic error estimate for the current method, which is further verified numerically. The results of various numerical experiments also suggest that this new approach is quite accurate, and can be easily extended to price other types of financial derivatives with an American-style exercise feature under the GMFBM model.

The influence of decadal scale climactic events on the transport of larvae.

NASA Astrophysics Data System (ADS)

Rasmuson, L. K.; Edwards, C. A.; Shanks, A.

2016-02-01

Understanding the processes that influence larval transport remains an important, yet difficult, task. This is especially true as more studies demonstrate that biological and physical oceanographic processes vary at long (e.g. decadal+) time scales. We used individual based biophysical models to study transport of Dungeness crab larvae (the most economically valuable fishery on the West Coast of the Continental United States) over a 10-year period; during both positive and negative phases of the Pacific decadal oscillation (PDO). A physical oceanographic model of the California current was developed using the Regional Ocean Modeling System with 1/30-degree resolution. Measured and modeled PDO indices were positively correlated. The biological model was implemented using the Lagrangian Transport Model, and modified to incorporate temperature dependent development and stage specific behaviors. Super individuals were used to scale production and incorporate mortality. Models were validated using time series statistics to compare measured and modeled daily recruitment. More larvae recruited, in both our measured and modeled time series, during negative PDOs. Our work suggests larvae exhibit a vertically migratory behavior too or almost too the bottom each day. During positive PDO years larvae were competent to settle earlier than negative PDO years, however, pelagic larval durations did not differ. The southern end of the population appears to be a sink population, which likely explains the decline in commercial catch. Ultimately, the population is much more demographically closed than previously thought. We hypothesize the stronger flow in the California current during negative PDO's enhances membership of larvae in the current. Further, migrating almost too the bottom causes larvae to enter the benthic boundary layer on the continental shelf and the California undercurrent on the continental slope, both, which decrease net alongshore advection. These factors result in a higher number of larvae closing their larval phase within the California current. We hypothesize Dungeness crabs have evolved to complete their larval phase within the oceanographic context of the California current and differences with the oceanography in the Alaska current may explain the difficulties in managing fisheries.

Risks, Risk Factors, and Outcomes Associated with Phone and Internet Sexting Among University Students in the United States.

PubMed

Dir, Allyson L; Cyders, Melissa A

2015-08-01

Sexting, defined as the exchange of sexually suggestive pictures or messages via mobile phone or social networking sites (SNS), has received media attention for its prevalence and associated negative outcomes; however, research has not yet fully established risk factors for and resulting outcomes from sexting behaviors. The current study was the first empirical test of a causal path model in males and females, in which impulsivity-related traits and expectancies influence sexual behaviors through phone and SNS sexting. We also examined prevalence and perceived likelihood of common negative outcomes associated with sexting. Multiple regression and structural equation modeling (SEM) statistics were conducted on two independent undergraduate samples (n = 611 and 255). The best fitting SEM model (RMSEA = 0.04, CFI = 0.96, TLI = 0.94, and χ(2) = 176.06, df = 75, p < .001) demonstrated a significant indirect effect of sensation seeking on phone sexting behaviors through sex-related sexting expectancies and a significant indirect effect of sensation seeking on sexual hookup behaviors through phone sexting behaviors (b = 0.06, p = .03), but only for females. Reverse mediations and mediation with SNS were not significant. Negative outcomes were rare: sexts being spread to others was the most common negative sexting experience (n = 21, 12 %). This study suggests the viability of personality and expectancies affecting sexual hookup behaviors through engagement in sexting behaviors. It also suggests that although direct negative outcomes associated with sexting are thought to be common, they were rare in the current sample.

Non-Destructive Techniques Based on Eddy Current Testing

PubMed Central

García-Martín, Javier; Gómez-Gil, Jaime; Vázquez-Sánchez, Ernesto

2011-01-01

Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future. PMID:22163754

Non-destructive techniques based on eddy current testing.

PubMed

García-Martín, Javier; Gómez-Gil, Jaime; Vázquez-Sánchez, Ernesto

2011-01-01

Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future.

DMSP F7 observations of a substorm field-aligned current

NASA Technical Reports Server (NTRS)

Lopez, R. E.; Spence, H. E.; Meng, C.-I.

1991-01-01

Observations are described of a substorm field-aligned current (FAC) system traversed by the DMSP F7 spacecraft just after 0300 UT on April 25, 1985. It is shown that the substorm FAC portion of the current system was located equatorward of the boundary between open and closed field lines. The equatorward boundary of the substorm FAC into the magnetotail was mapped using the Tsyganenko (1987) model, showing that the boundary corresponds to 6.9 earth radii. The result is consistent with the suggestion of Akasofu (1972) and Lopez and Lui (1990) that the region of substorm initiation lies relatively close to the earth and the concept that an essential feature of substorms is the disruption and diversion of the near-earth current sheet.

Development of self-control in children aged 3 to 9 years: Perspective from a dual-systems model

PubMed Central

Tao, Ting; Wang, Ligang; Fan, Chunlei; Gao, Wenbin

2014-01-01

The current study tested a set of interrelated theoretical propositions based on a dual-systems model of self-control. Data were collected from 2135 children aged 3 to 9 years. The results suggest that (a) there was positive growth in good self-control, whereas poor control remained relatively stable; and (b) girls performed better than boys on tests of good self-control. The results are discussed in terms of their implications for a dual-systems model of self-control theory and future empirical work. PMID:25501669

Source term model evaluations for the low-level waste facility performance assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yim, M.S.; Su, S.I.

1995-12-31

The estimation of release of radionuclides from various waste forms to the bottom boundary of the waste disposal facility (source term) is one of the most important aspects of LLW facility performance assessment. In this work, several currently used source term models are comparatively evaluated for the release of carbon-14 based on a test case problem. The models compared include PRESTO-EPA-CPG, IMPACTS, DUST and NEFTRAN-II. Major differences in assumptions and approaches between the models are described and key parameters are identified through sensitivity analysis. The source term results from different models are compared and other concerns or suggestions are discussed.

Validation and sensitivity of the FINE Bayesian network for forecasting aquatic exposure to nano-silver.

PubMed

Money, Eric S; Barton, Lauren E; Dawson, Joseph; Reckhow, Kenneth H; Wiesner, Mark R

2014-03-01

The adaptive nature of the Forecasting the Impacts of Nanomaterials in the Environment (FINE) Bayesian network is explored. We create an updated FINE model (FINEAgNP-2) for predicting aquatic exposure concentrations of silver nanoparticles (AgNP) by combining the expert-based parameters from the baseline model established in previous work with literature data related to particle behavior, exposure, and nano-ecotoxicology via parameter learning. We validate the AgNP forecast from the updated model using mesocosm-scale field data and determine the sensitivity of several key variables to changes in environmental conditions, particle characteristics, and particle fate. Results show that the prediction accuracy of the FINEAgNP-2 model increased approximately 70% over the baseline model, with an error rate of only 20%, suggesting that FINE is a reliable tool to predict aquatic concentrations of nano-silver. Sensitivity analysis suggests that fractal dimension, particle diameter, conductivity, time, and particle fate have the most influence on aquatic exposure given the current knowledge; however, numerous knowledge gaps can be identified to suggest further research efforts that will reduce the uncertainty in subsequent exposure and risk forecasts. Copyright © 2013 Elsevier B.V. All rights reserved.

Categorical and dimensional approaches in the evaluation of the relationship between attachment and personality disorders: an empirical study.

PubMed

Chiesa, Marco; Cirasola, Antonella; Williams, Riccardo; Nassisi, Valentina; Fonagy, Peter

2017-04-01

Although several studies have highlighted the relationship between attachment states of mind and personality disorders, their findings have not been consistent, possibly due to the application of the traditional taxonomic classification model of attachment. A more recently developed dimensional classification of attachment representations, including more specific aspects of trauma-related representations, may have advantages. In this study, we compare specific associations and predictive power of the categorical attachment and dimensional models applied to 230 Adult Attachment Interview transcripts obtained from personality disordered and nonpsychiatric subjects. We also investigate the role that current levels of psychiatric distress may have in the prediction of PD. The results showed that both models predict the presence of PD, with the dimensional approach doing better in discriminating overall diagnosis of PD. However, both models are less helpful in discriminating specific PD diagnostic subtypes. Current psychiatric distress was found to be the most consistent predictor of PD capturing a large share of the variance and obscuring the role played by attachment variables. The results suggest that attachment parameters correlate with the presence of PD alone and have no specific associations with particular PD subtypes when current psychiatric distress is taken into account.

Altered ion transport by thyroid epithelia from CFTR−/− pigs suggests mechanisms for hypothyroidism in Cystic Fibrosis

PubMed Central

Li, Hui; Ganta, Suhasini; Fong, Peying

2010-01-01

Subclinical hypothyroidism has been linked to Cystic Fibrosis (CF), and the cystic fibrosis transmembrane conductance regulator (CFTR) shown to be expressed in the thyroid. The thyroid epithelium secretes Cl− and absorbs Na+ in response to cAMP. Chloride secretion may provide a counter-ion for the SLC26A4 (Pendrin)-mediated I− secretion which is required for the first step of thyroid hormonogenesis, thyroglobulin iodination. In contrast, few models exist to explain a role for Na+ absorption. Whether CFTR mediates the secretory Cl− current in thyroid epithelium has not been directly addressed. We used thyroids from a novel pig CFTR−/− model, generated primary pig thyroid epithelial cell cultures (pThECs), analyzed these cultures for preservation of thyroid-specific transcripts and proteins, and monitored 1) the Cl− secretory response to the cAMP agonist, isoproterenol and 2) the amiloride-sensitive Na+ current. Baseline short-circuit current (Isc) did not differ between CFTR+/+ and CFTR−/− cultures. Serosal isoproterenol increased Isc in CFTR+/+, but not CFTR−/−, monolayers. Compared to CFTR+/+ thyroid cultures, amiloride-sensitive Na+ absorption measured in CFTR−/− pThECs represented a greater fraction of the resting Isc. However, levels of transcripts encoding ENaC subunits did not differ between CFTR+/+ and CFTR−/− pThECs. Immunoblot analysis verified ENaC subunit protein expression, but quantification indicated no difference in expression levels. Our studies definitively demonstrate that CFTR mediates cAMP-stimulated Cl− secretion in a well-differentiated thyroid culture model, and that knockout of CFTR promotes increased Na+ absorption by a mechanism other than increased ENaC expression. These findings suggest several models for the mechanism of CF-associated hypothyroidism. PMID:20729267

Ceres Evolution: From Thermodynamic Modeling and Now Dawn Observation

NASA Astrophysics Data System (ADS)

McCord, T. B.; Combe, J. P.; Castillo, J. C.; Raymond, C. A.; De Sanctis, M. C.; Jaumann, R.; Ammannito, E.; Russell, C. T.

2015-12-01

Thermodynamic modeling indicated that Ceres has experienced planetary processes, including extensive melting of its ~25% water and differentiation, (McCord and Sotin, JGR, 2005; Castillo and McCord, Icarus, 2009). Early telescopic studies showed Ceres' surface to be spectrally similar to carboneous-chondrite-like material, i.e., aqueously altered silicates darkened by carbon, with a water-OH-related absorption near 3.06 µm. Later observations improved the spectra and suggested more specific interpretations: Structural water in clay minerals, phyllosilicates, perhaps ammoniated, iron-rich clays, carbonates, brucite, all implying extensive aqueous alteration, perhaps in the presence of CO2. Telescopic observations and thermodynamic models predicted Dawn would find a very different body compared to Vesta (e.g. McCord et al., SSR, 2011), as current Dawn observations are confirming. Ceres' original water ice should have melted early in its evolution, with the resulting differentiation and mineralization strongly affecting Ceres' composition, size and shape over time. The ocean should have become very salty and perhaps may still be liquid in places. The surface composition from telescopes seems to reflect this complex history. The mineralization with repeated mixing of the crust with the early liquid interior and with in-fall from space would create a complex surface that will present an interpretation challenge for Dawn. The Dawn spacecraft is currently collecting observations of Ceres' landforms, elemental and mineralogical/molecular composition and gravity field from orbit. Early results suggest a heavily cratered but distorted and lumpy body with features and composition consistent with internal activity, perhaps recent or current, associated with water and perhaps other volatiles. We will present and interpret the latest Dawn Ceres findings and how they affect our earlier understanding of Ceres evolution from modeling and telescope observations.

Earth's magnetic field is probably not reversing.

PubMed

Brown, Maxwell; Korte, Monika; Holme, Richard; Wardinski, Ingo; Gunnarson, Sydney

2018-05-15

The geomagnetic field has been decaying at a rate of ∼5% per century from at least 1840, with indirect observations suggesting a decay since 1600 or even earlier. This has led to the assertion that the geomagnetic field may be undergoing a reversal or an excursion. We have derived a model of the geomagnetic field spanning 30-50 ka, constructed to study the behavior of the two most recent excursions: the Laschamp and Mono Lake, centered at 41 and 34 ka, respectively. Here, we show that neither excursion demonstrates field evolution similar to current changes in the geomagnetic field. At earlier times, centered at 49 and 46 ka, the field is comparable to today's field, with an intensity structure similar to today's South Atlantic Anomaly (SAA); however, neither of these SAA-like fields develop into an excursion or reversal. This suggests that the current weakened field will also recover without an extreme event such as an excursion or reversal. The SAA-like field structure at 46 ka appears to be coeval with published increases in geomagnetically modulated beryllium and chlorine nuclide production, despite the global dipole field not weakening significantly in our model during this time. This agreement suggests a greater complexity in the relationship between cosmogenic nuclide production and the geomagnetic field than is commonly assumed.

Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease.

PubMed

Carman, A J; Dacks, P A; Lane, R F; Shineman, D W; Fillit, H M

2014-04-01

Although nothing has been proven conclusively to protect against cognitive aging, Alzheimer's disease or related dementias, decades of research suggest that specific approaches including the consumption of coffee may be effective. While coffee and caffeine are known to enhance short-term memory and cognition, some limited research also suggests that long-term use may protect against cognitive decline or dementia. In vitro and pre-clinical animal models have identified plausible neuroprotective mechanisms of action of both caffeine and other bioactive components of coffee, though epidemiology has produced mixed results. Some studies suggest a protective association while others report no benefit. To our knowledge, no evidence has been gathered from randomized controlled trials. Although moderate consumption of caffeinated coffee is generally safe for healthy people, it may not be for everyone, since comorbidities and personal genetics influence potential benefits and risks. Future studies could include short-term clinical trials with biomarker outcomes to validate findings from pre-clinical models and improved epidemiological studies that incorporate more standardized methods of data collection and analysis. Given the enormous economic and emotional toll threatened by the current epidemic of Alzheimer's disease and other dementias, it is critically important to validate potential prevention strategies such as coffee and caffeine.

Describing complex cells in primary visual cortex: a comparison of context and multi-filter LN models.

PubMed

Westö, Johan; May, Patrick J C

2018-05-02

Receptive field (RF) models are an important tool for deciphering neural responses to sensory stimuli. The two currently popular RF models are multi-filter linear-nonlinear (LN) models and context models. Models are, however, never correct and they rely on assumptions to keep them simple enough to be interpretable. As a consequence, different models describe different stimulus-response mappings, which may or may not be good approximations of real neural behavior. In the current study, we take up two tasks: First, we introduce new ways to estimate context models with realistic nonlinearities, that is, with logistic and exponential functions. Second, we evaluate context models and multi-filter LN models in terms of how well they describe recorded data from complex cells in cat primary visual cortex. Our results, based on single-spike information and correlation coefficients, indicate that context models outperform corresponding multi-filter LN models of equal complexity (measured in terms of number of parameters), with the best increase in performance being achieved by the novel context models. Consequently, our results suggest that the multi-filter LN-model framework is suboptimal for describing the behavior of complex cells: the context-model framework is clearly superior while still providing interpretable quantizations of neural behavior.

Mutual Inductance Problem for a System Consisting of a Current Sheet and a Thin Metal Plate

NASA Technical Reports Server (NTRS)

Fulton, J. P.; Wincheski, B.; Nath, S.; Namkung, M.

1993-01-01

Rapid inspection of aircraft structures for flaws is of vital importance to the commercial and defense aircraft industry. In particular, inspecting thin aluminum structures for flaws is the focus of a large scale R&D effort in the nondestructive evaluation (NDE) community. Traditional eddy current methods used today are effective, but require long inspection times. New electromagnetic techniques which monitor the normal component of the magnetic field above a sample due to a sheet of current as the excitation, seem to be promising. This paper is an attempt to understand and analyze the magnetic field distribution due to a current sheet above an aluminum test sample. A simple theoretical model, coupled with a two dimensional finite element model (FEM) and experimental data will be presented in the next few sections. A current sheet above a conducting sample generates eddy currents in the material, while a sensor above the current sheet or in between the two plates monitors the normal component of the magnetic field. A rivet or a surface flaw near a rivet in an aircraft aluminum skin will disturb the magnetic field, which is imaged by the sensor. Initial results showed a strong dependence of the flaw induced normal magnetic field strength on the thickness and conductivity of the current-sheet that could not be accounted for by skin depth attenuation alone. It was believed that the eddy current imaging method explained the dependence of the thickness and conductivity of the flaw induced normal magnetic field. Further investigation, suggested the complexity associated with the mutual inductance of the system needed to be studied. The next section gives an analytical model to better understand the phenomenon.

A Sixteen-year Decline in Dissolved Oxygen in the Central California Current.

PubMed

Ren, Alice S; Chai, Fei; Xue, Huijie; Anderson, David M; Chavez, Francisco P

2018-05-08

A potential consequence of climate change is global decrease in dissolved oxygen at depth in the oceans due to changes in the balance of ventilation, mixing, respiration, and photosynthesis. We present hydrographic cruise observations of declining dissolved oxygen collected along CalCOFI Line 66.7 (Line 67) off of Monterey Bay, in the Central California Current region, and investigate likely mechanisms. Between 1998 and 2013, dissolved oxygen decreased at the mean rate of 1.92 µmol kg -1 year -1 on σ θ 26.6-26.8 kg m -3 isopycnals (250-400 m), translating to a 40% decline from initial concentrations. Two cores of elevated dissolved oxygen decline at 130 and 240 km from shore, which we suggest are a California Undercurrent and a California Current signal respectively, occurred on σ θ ranges of 26.0-26.8 kg m -3 (100-400 m). A box model suggests that small annual changes in dissolved oxygen in source regions are sufficient to be the primary driver of the mid-depth declines. Variation in dissolved oxygen at the bottom of the surface mixed layer suggests that there is also a signal of increased local remineralization.

Model-based learning and the contribution of the orbitofrontal cortex to the model-free world

PubMed Central

McDannald, Michael A.; Takahashi, Yuji K.; Lopatina, Nina; Pietras, Brad W.; Jones, Josh L.; Schoenbaum, Geoffrey

2012-01-01

Learning is proposed to occur when there is a discrepancy between reward prediction and reward receipt. At least two separate systems are thought to exist: one in which predictions are proposed to be based on model-free or cached values; and another in which predictions are model-based. A basic neural circuit for model-free reinforcement learning has already been described. In the model-free circuit the ventral striatum (VS) is thought to supply a common-currency reward prediction to midbrain dopamine neurons that compute prediction errors and drive learning. In a model-based system, predictions can include more information about an expected reward, such as its sensory attributes or current, unique value. This detailed prediction allows for both behavioral flexibility and learning driven by changes in sensory features of rewards alone. Recent evidence from animal learning and human imaging suggests that, in addition to model-free information, the VS also signals model-based information. Further, there is evidence that the orbitofrontal cortex (OFC) signals model-based information. Here we review these data and suggest that the OFC provides model-based information to this traditional model-free circuitry and offer possibilities as to how this interaction might occur. PMID:22487030

Computational Fluid Dynamics of Choanoflagellate Filter-Feeding

NASA Astrophysics Data System (ADS)

Asadzadeh, Seyed Saeed; Walther, Jens; Nielsen, Lasse Tore; Kiorboe, Thomas; Dolger, Julia; Andersen, Anders

2017-11-01

Choanoflagellates are unicellular aquatic organisms with a single flagellum that drives a feeding current through a funnel-shaped collar filter on which bacteria-sized prey are caught. Using computational fluid dynamics (CFD) we model the beating flagellum and the complex filter flow of the choanoflagellate Diaphanoeca grandis. Our CFD simulations based on the current understanding of the morphology underestimate the experimentally observed clearance rate by more than an order of magnitude: The beating flagellum is simply unable to draw enough water through the fine filter. Our observations motivate us to suggest a radically different filtration mechanism that requires a flagellar vane (sheet), and addition of a wide vane in our CFD model allows us to correctly predict the observed clearance rate.

Further characterisation of the functional neuroanatomy associated with prosodic emotion decoding.

PubMed

Mitchell, Rachel L C

2013-06-01

Current models of prosodic emotion comprehension propose a three stage cognition mediated by temporal lobe auditory regions through to inferior and orbitofrontal regions. Cumulative evidence suggests that its mediation may be more flexible though, with a facility to respond in a graded manner based on the need for executive control. The location of this fine-tuning system is unclear, as is its similarity to the cognitive control system. In the current study, need for executive control was manipulated in a block-design functional MRI study by systematically altering the proportion of incongruent trials across time, i.e., trials for which participants identified prosodic emotions in the face of conflicting lexico-semantic emotion cues. Resultant Blood Oxygenation Level Dependent contrast data were analysed according to standard procedures using Statistical Parametric Mapping v8 (Ashburner et al., 2009). In the parametric analyses, superior (medial) frontal gyrus activity increased linearly with increased need for executive control. In the separate analyses of each level of incongruity, results suggested that the baseline prosodic emotion comprehension system was sufficient to deal with low proportions of incongruent trials, whereas a more widespread frontal lobe network was required for higher proportions. These results suggest an executive control system for prosodic emotion comprehension exists which has the capability to recruit superior (medial) frontal gyrus in a graded manner and other frontal regions once demand exceeds a certain threshold. The need to revise current models of prosodic emotion comprehension and add a fourth processing stage are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Safety parameter considerations of anodal transcranial Direct Current Stimulation in rats.

PubMed

Jackson, Mark P; Truong, Dennis; Brownlow, Milene L; Wagner, Jessica A; McKinley, R Andy; Bikson, Marom; Jankord, Ryan

2017-08-01

A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g. anodal tDCS), sub-lesion threshold injury (e.g. neuroinflammatory processes), and role of electrode montage across rodent and human studies support further investigation into animal models of tDCS safety. Thirty-two anesthetized rats received anodal tDCS between 0 and 5mA for 60min through one of three epicranial electrode montages. Tissue damage was evaluated using hemotoxylin and eosin (H&E) staining, Iba-1 immunohistochemistry, and computational brain current density modeling. Brain lesion occurred after anodal tDCS at and above 0.5mA using a 25.0mm 2 electrode (electrode current density: 20.0A/m 2 ). Lesion initially occurred using smaller 10.6mm 2 or 5.3mm 2 electrodes at 0.25mA (23.5A/m 2 ) and 0.5mA (94.2A/m 2 ), respectively. Histological damage was correlated with computational brain current density predictions. Changes in microglial phenotype occurred in higher stimulation groups. Lesions were observed using anodal tDCS at an electrode current density of 20.0A/m 2 , which is below the previously reported safety threshold of 142.9A/m 2 using cathodal tDCS. The lesion area is not simply predicted by electrode current density (and so not by charge density as duration was fixed); rather computational modeling suggests average brain current density as a better predictor for anodal tDCS. Nonetheless, under the assumption that rodent epicranial stimulation is a hypersensitive model, an electrode current density of 20.0A/m 2 represents a conservative threshold for clinical tDCS, which typically uses an electrode current density of 2A/m 2 when electrodes are placed on the skin (resulting in a lower brain current density). Copyright © 2017 Elsevier Inc. All rights reserved.

On combination of strict Bayesian principles with model reduction technique or how stochastic model calibration can become feasible for large-scale applications

NASA Astrophysics Data System (ADS)

Oladyshkin, S.; Schroeder, P.; Class, H.; Nowak, W.

2013-12-01

Predicting underground carbon dioxide (CO2) storage represents a challenging problem in a complex dynamic system. Due to lacking information about reservoir parameters, quantification of uncertainties may become the dominant question in risk assessment. Calibration on past observed data from pilot-scale test injection can improve the predictive power of the involved geological, flow, and transport models. The current work performs history matching to pressure time series from a pilot storage site operated in Europe, maintained during an injection period. Simulation of compressible two-phase flow and transport (CO2/brine) in the considered site is computationally very demanding, requiring about 12 days of CPU time for an individual model run. For that reason, brute-force approaches for calibration are not feasible. In the current work, we explore an advanced framework for history matching based on the arbitrary polynomial chaos expansion (aPC) and strict Bayesian principles. The aPC [1] offers a drastic but accurate stochastic model reduction. Unlike many previous chaos expansions, it can handle arbitrary probability distribution shapes of uncertain parameters, and can therefore handle directly the statistical information appearing during the matching procedure. We capture the dependence of model output on these multipliers with the expansion-based reduced model. In our study we keep the spatial heterogeneity suggested by geophysical methods, but consider uncertainty in the magnitude of permeability trough zone-wise permeability multipliers. Next combined the aPC with Bootstrap filtering (a brute-force but fully accurate Bayesian updating mechanism) in order to perform the matching. In comparison to (Ensemble) Kalman Filters, our method accounts for higher-order statistical moments and for the non-linearity of both the forward model and the inversion, and thus allows a rigorous quantification of calibrated model uncertainty. The usually high computational costs of accurate filtering become very feasible for our suggested aPC-based calibration framework. However, the power of aPC-based Bayesian updating strongly depends on the accuracy of prior information. In the current study, the prior assumptions on the model parameters were not satisfactory and strongly underestimate the reservoir pressure. Thus, the aPC-based response surface used in Bootstrap filtering is fitted to a distant and poorly chosen region within the parameter space. Thanks to the iterative procedure suggested in [2] we overcome this drawback with small computational costs. The iteration successively improves the accuracy of the expansion around the current estimation of the posterior distribution. The final result is a calibrated model of the site that can be used for further studies, with an excellent match to the data. References [1] Oladyshkin S. and Nowak W. Data-driven uncertainty quantification using the arbitrary polynomial chaos expansion. Reliability Engineering and System Safety, 106:179-190, 2012. [2] Oladyshkin S., Class H., Nowak W. Bayesian updating via Bootstrap filtering combined with data-driven polynomial chaos expansions: methodology and application to history matching for carbon dioxide storage in geological formations. Computational Geosciences, 17 (4), 671-687, 2013.

Comparative modelling of lower hybrid current drive with two launcher designs in the Tore Supra tokamak

NASA Astrophysics Data System (ADS)

Nilsson, E.; Decker, J.; Peysson, Y.; Artaud, J.-F.; Ekedahl, A.; Hillairet, J.; Aniel, T.; Basiuk, V.; Goniche, M.; Imbeaux, F.; Mazon, D.; Sharma, P.

2013-08-01

Fully non-inductive operation with lower hybrid current drive (LHCD) in the Tore Supra tokamak is achieved using either a fully active multijunction (FAM) launcher or a more recent ITER-relevant passive active multijunction (PAM) launcher, or both launchers simultaneously. While both antennas show comparable experimental efficiencies, the analysis of stability properties in long discharges suggest different current profiles. We present comparative modelling of LHCD with the two different launchers to characterize the effect of the respective antenna spectra on the driven current profile. The interpretative modelling of LHCD is carried out using a chain of codes calculating, respectively, the global discharge evolution (tokamak simulator METIS), the spectrum at the antenna mouth (LH coupling code ALOHA), the LH wave propagation (ray-tracing code C3PO), and the distribution function (3D Fokker-Planck code LUKE). Essential aspects of the fast electron dynamics in time, space and energy are obtained from hard x-ray measurements of fast electron bremsstrahlung emission using a dedicated tomographic system. LHCD simulations are validated by systematic comparisons between these experimental measurements and the reconstructed signal calculated by the code R5X2 from the LUKE electron distribution. An excellent agreement is obtained in the presence of strong Landau damping (found under low density and high-power conditions in Tore Supra) for which the ray-tracing model is valid for modelling the LH wave propagation. Two aspects of the antenna spectra are found to have a significant effect on LHCD. First, the driven current is found to be proportional to the directivity, which depends upon the respective weight of the main positive and main negative lobes and is particularly sensitive to the density in front of the antenna. Second, the position of the main negative lobe in the spectrum is different for the two launchers. As this lobe drives a counter-current, the resulting driven current profile is also different for the FAM and PAM launchers.

Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse.

PubMed

Cazer, Casey L; Ducrot, Lucas; Volkova, Victoriya V; Gröhn, Yrjö T

2017-01-01

Antimicrobial use in beef cattle can increase antimicrobial resistance prevalence in their enteric bacteria, including potential pathogens such as Escherichia coli . These bacteria can contaminate animal products at slaughterhouses and cause food-borne illness, which can be difficult to treat if it is due to antimicrobial resistant bacteria. One potential intervention to reduce the dissemination of resistant bacteria from feedlot to consumer is to impose a withdrawal period after antimicrobial use, similar to the current withdrawal period designed to prevent drug residues in edible animal meat. We investigated tetracycline resistance in generic E. coli in the bovine large intestine during and after antimicrobial treatment by building a mathematical model of oral chlortetracycline pharmacokinetics-pharmacodynamics and E. coli population dynamics. We tracked three E. coli subpopulations (susceptible, intermediate, and resistant) during and after treatment with each of three United States chlortetracycline indications (liver abscess reduction, disease control, disease treatment). We compared the proportion of resistant E. coli before antimicrobial use to that at several time points after treatment and found a greater proportion of resistant enteric E. coli after the current withdrawal periods than prior to treatment. In order for the proportion of resistant E. coli in the median beef steer to return to the pre-treatment level, withdrawal periods of 15 days after liver abscess reduction dosing (70 mg daily), 31 days after disease control dosing (350 mg daily), and 36 days after disease treatment dosing (22 mg/kg bodyweight for 5 days) are required in this model. These antimicrobial resistance withdrawal periods would be substantially longer than the current U.S. withdrawals of 0-2 days or Canadian withdrawals of 5-10 days. One published field study found similar time periods necessary to reduce the proportion of resistant E. coli following chlortetracycline disease treatment to those suggested by this model, but additional carefully designed field studies are necessary to confirm the model results. This model is limited to biological processes within the cattle and does not include resistance selection in the feedlot environment or co-selection of chlortetracycline resistance following other antimicrobial use.

Short-term Influences on Suspended Particulate Matter Distribution in the Northern Gulf of Mexico: Satellite and Model Observations.

PubMed

D'Sa, Eurico J; Ko, Dong S

2008-07-15

Energetic meteorological events such as frontal passages and hurricanes often impact coastal regions in the northern Gulf of Mexico that influence geochemical processes in the region. Satellite remote sensing data such as winds from QuikSCAT, suspended particulate matter (SPM) concentrations derived from SeaWiFS and the outputs (sea level and surface ocean currents) of a nested navy coastal ocean model (NCOM) were combined to assess the effects of frontal passages between 23-28 March 2005 on the physical properties and the SPM characteristics in the northern Gulf of Mexico. Typical changes in wind speed and direction associated with frontal passages were observed in the latest 12.5 km wind product from QuikSCAT with easterly winds before the frontal passage undergoing systematic shifts in direction and speed and turning northerly, northwesterly during a weak and a strong front on 23 and 27 March, respectively. A quantitative comparison of model sea level results with tide gauge observations suggest better correlations near the delta than in the western part of the Gulf with elevated sea levels along the coast before the frontal passage and a large drop in sea level following the frontal passage on 27 March. Model results of surface currents suggested strong response to wind forcing with westward and onshore currents before the frontal passage reversing into eastward, southeastward direction over a six day period from 23 to 28 March 2005. Surface SPM distribution derived from SeaWiFS ocean color data for two clear days on 23 and 28 March 2005 indicated SPM plumes to be oriented with the current field with increasing concentrations in nearshore waters due to resuspension and discharge from the rivers and bays and its seaward transport following the frontal passage. The backscattering spectral slope γ, a parameter sensitive to particle size distribution also indicated lower γ values (larger particles) in nearshore waters that decreased offshore (smaller particles). The use of both satellite and model results revealed the strong interactions between physical processes and the surface particulate field in response to the frontal passage in a large riverdominated coastal margin.

Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse

PubMed Central

Cazer, Casey L.; Ducrot, Lucas; Volkova, Victoriya V.; Gröhn, Yrjö T.

2017-01-01

Antimicrobial use in beef cattle can increase antimicrobial resistance prevalence in their enteric bacteria, including potential pathogens such as Escherichia coli. These bacteria can contaminate animal products at slaughterhouses and cause food-borne illness, which can be difficult to treat if it is due to antimicrobial resistant bacteria. One potential intervention to reduce the dissemination of resistant bacteria from feedlot to consumer is to impose a withdrawal period after antimicrobial use, similar to the current withdrawal period designed to prevent drug residues in edible animal meat. We investigated tetracycline resistance in generic E. coli in the bovine large intestine during and after antimicrobial treatment by building a mathematical model of oral chlortetracycline pharmacokinetics-pharmacodynamics and E. coli population dynamics. We tracked three E. coli subpopulations (susceptible, intermediate, and resistant) during and after treatment with each of three United States chlortetracycline indications (liver abscess reduction, disease control, disease treatment). We compared the proportion of resistant E. coli before antimicrobial use to that at several time points after treatment and found a greater proportion of resistant enteric E. coli after the current withdrawal periods than prior to treatment. In order for the proportion of resistant E. coli in the median beef steer to return to the pre-treatment level, withdrawal periods of 15 days after liver abscess reduction dosing (70 mg daily), 31 days after disease control dosing (350 mg daily), and 36 days after disease treatment dosing (22 mg/kg bodyweight for 5 days) are required in this model. These antimicrobial resistance withdrawal periods would be substantially longer than the current U.S. withdrawals of 0–2 days or Canadian withdrawals of 5–10 days. One published field study found similar time periods necessary to reduce the proportion of resistant E. coli following chlortetracycline disease treatment to those suggested by this model, but additional carefully designed field studies are necessary to confirm the model results. This model is limited to biological processes within the cattle and does not include resistance selection in the feedlot environment or co-selection of chlortetracycline resistance following other antimicrobial use. PMID:29033901

The relationship between climate change and the endangered rainforest shrub Triunia robusta (Proteaceae) endemic to southeast Queensland, Australia

NASA Astrophysics Data System (ADS)

Shimizu-Kimura, Yoko; Accad, Arnon; Shapcott, Alison

2017-04-01

Threatened species in rainforests may be vulnerable to climate change, because of their potentially narrow thermal tolerances, small population sizes and restricted distributions. This study modelled climate induced changes on the habitat distribution of the endangered rainforest plant Triunia robusta, endemic to southeast Queensland, Australia. Species distribution models were developed for eastern Australia at 250 m grids and southeast Queensland at 25 m grids using ground-truthed presence records and environmental predictor data. The species’ habitat distribution under the current climate was modelled, and the future potential habitat distributions were projected for the epochs 2030, 2050 and 2070. The eastern Australia model identified several spatially disjunct, broad habitat areas of coastal eastern Australia consistent with the current distribution of rainforests, and projected a southward and upslope contraction driven mainly by average temperatures exceeding current range limits. The southeast Queensland models suggest a dramatic upslope contraction toward locations where the majority of known populations are found. Populations located in the Sunshine Coast hinterland, consistent with past rainforest refugia, are likely to persist long-term. Upgrading the level of protection for less formal nature reserves containing viable populations is a high priority to better protect refugial T. robusta populations with respect to climate change.

Multi-phase models for water and thermal management of proton exchange membrane fuel cell: A review

NASA Astrophysics Data System (ADS)

Zhang, Guobin; Jiao, Kui

2018-07-01

The 3D (three-dimensional) multi-phase CFD (computational fluid dynamics) model is widely utilized in optimizing water and thermal management of PEM (proton exchange membrane) fuel cell. However, a satisfactory 3D multi-phase CFD model which is able to simulate the detailed gas and liquid two-phase flow in channels and reflect its effect on performance precisely is still not developed due to the coupling difficulties and computation amount. Meanwhile, the agglomerate model of CL (catalyst layer) should also be added in 3D CFD model so as to better reflect the concentration loss and optimize CL structure in macroscopic scale. Besides, the effect of thermal management is perhaps underestimated in current 3D multi-phase CFD simulations due to the lack of coolant channel in computation domain and constant temperature boundary condition. Therefore, the 3D CFD simulations in cell and stack levels with convection boundary condition are suggested to simulate the water and thermal management more accurately. Nevertheless, with the rapid development of PEM fuel cell, current 3D CFD simulations are far from practical demand, especially at high current density and low to zero humidity and for the novel designs developed recently, such as: metal foam flow field, 3D fine mesh flow field, anode circulation etc.

Modeling the effects of phosphor converted LED lighting to the night sky of the Haleakala Observatory, Hawaii

NASA Astrophysics Data System (ADS)

Aubé, M.; Simoneau, A.; Wainscoat, R.; Nelson, L.

2018-05-01

The goal of this study is to evaluate the current level of light pollution in the night sky at the Haleakala Observatory on the island of Maui in Hawaii. This is accomplished with a numerical model that was tested in the first International Dark Sky Reserve located in Mont-Mégantic National Park in Canada. The model uses ground data on the artificial light sources present in the region of study, geographical data, and remotely sensed data for: 1) the nightly upward radiance; 2) the terrain elevation; and, 3) the ground spectral reflectance of the region. The results of the model give a measure of the current state of the sky spectral radiance at the Haleakala Observatory. Then, using the current state as a reference point, multiple light conversion plans are elaborated and evaluated using the model. We can thus estimate the expected impact of each conversion plan on the night sky radiance spectrum. A complete conversion to white (LEDs) with (CCT) of 4000K and 3000K are contrasted with a conversion using (PC) amber (LEDs). We include recommendations concerning the street lamps to be used in sensitive areas like the cities of Kahului and Kihei and suggest best lighting practices related to the color of lamps used at night.

The relationship between climate change and the endangered rainforest shrub Triunia robusta (Proteaceae) endemic to southeast Queensland, Australia

PubMed Central

Shimizu-Kimura, Yoko; Accad, Arnon; Shapcott, Alison

2017-01-01

Threatened species in rainforests may be vulnerable to climate change, because of their potentially narrow thermal tolerances, small population sizes and restricted distributions. This study modelled climate induced changes on the habitat distribution of the endangered rainforest plant Triunia robusta, endemic to southeast Queensland, Australia. Species distribution models were developed for eastern Australia at 250 m grids and southeast Queensland at 25 m grids using ground-truthed presence records and environmental predictor data. The species’ habitat distribution under the current climate was modelled, and the future potential habitat distributions were projected for the epochs 2030, 2050 and 2070. The eastern Australia model identified several spatially disjunct, broad habitat areas of coastal eastern Australia consistent with the current distribution of rainforests, and projected a southward and upslope contraction driven mainly by average temperatures exceeding current range limits. The southeast Queensland models suggest a dramatic upslope contraction toward locations where the majority of known populations are found. Populations located in the Sunshine Coast hinterland, consistent with past rainforest refugia, are likely to persist long-term. Upgrading the level of protection for less formal nature reserves containing viable populations is a high priority to better protect refugial T. robusta populations with respect to climate change. PMID:28422136

Future Warming Patterns Linked to Today's Climate Variability.

PubMed

Dai, Aiguo

2016-01-11

The reliability of model projections of greenhouse gas (GHG)-induced future climate change is often assessed based on models' ability to simulate the current climate, but there has been little evidence that connects the two. In fact, this practice has been questioned because the GHG-induced future climate change may involve additional physical processes that are not important for the current climate. Here I show that the spatial patterns of the GHG-induced future warming in the 21(st) century is highly correlated with the patterns of the year-to-year variations of surface air temperature for today's climate, with areas of larger variations during 1950-1979 having more GHG-induced warming in the 21(st) century in all climate models. Such a relationship also exists in other climate fields such as atmospheric water vapor, and it is evident in observed temperatures from 1950-2010. The results suggest that many physical processes may work similarly in producing the year-to-year climate variations in the current climate and the GHG-induced long-term changes in the 21(st) century in models and in the real world. They support the notion that models that simulate present-day climate variability better are likely to make more reliable predictions of future climate change.

Every Citizen a Soldier: Historic Foundations for Gender Integrated Training (GIT) and Implications for Air Force Readiness

DTIC Science & Technology

1999-04-01

masculine world. Noted military experts suggest pluralism is the desired end state for successful gender integrated service, and this concept is...book in progress, Dr. Dunivin discusses two, current U.S. 5 military culture models. The first is the Traditional Model, termed the Combat Masculine ... Masculine Warrior. Charles Moskos, cited by Dunivin, describes what the 6 Combat Masculine Warrior paradigm actually means to the military: “Thus a

Simulation of action potentials from metabolically impaired cardiac myocytes. Role of ATP-sensitive K+ current.

PubMed

Ferrero, J M; Sáiz, J; Ferrero, J M; Thakor, N V

1996-08-01

The role of the ATP-sensitive K+ current (IK-ATP) and its contribution to electrophysiological changes that occur during metabolic impairment in cardiac ventricular myocytes is still being discussed. The aim of this work was to quantitatively study this issue by using computer modeling. A model of IK-ATP is formulated and incorporated into the Luo-Rudy ionic model of the ventricular action potential. Action potentials under different degrees of activation of IK-ATP are simulated. Our results show that in normal ionic concentrations, only approximately 0.6% of the KATP channels, when open, should account for a 50% reduction in action potential duration. However, increased levels of intracellular Mg2+ counteract this shortening. Under conditions of high [K+]0, such as those found in early ischemia, the activation of only approximately 0.4% of the KATP channels could account for a 50% reduction in action potential duration. Thus, our results suggest that opening of IK-ATP channels should play a significant role in action potential shortening during hypoxic/ischemic episodes, with the fraction of open channels involved being very low ( < 1%). However, the results of the model suggest that activation of IK-ATP alone does not quantitatively account for the observed K+ efflux in metabolically impaired cardiac myocytes. Mechanisms other than KATP channel activation should be responsible for a significant part of the K+ efflux measured in hypoxic/ischemic situations.

Reducing Potentially Avoidable Complications in Patients with Chronic Diseases: The Prometheus Payment Approach

PubMed Central

de Brantes, Francois; Rastogi, Amita; Painter, Michael

2010-01-01

Objective (or Study Question) To determine whether a new payment model can reduce current incidence of potentially avoidable complications (PACs) in patients with a chronic illness. Data Sources/Study Setting A claims database of 3.5 million commercially insured members under age 65. Study Design We analyzed the database using the Prometheus Payment model's analytical software for six chronic conditions to quantify total costs, proportion spent on PACs, and their variability across the United States. We conducted a literature review to determine the feasibility of reducing PACs. We estimated the financial impact on a prototypical practice if that practice received payments based on the Prometheus Payment model. Principal Findings We find that (1) PACs consume an average of 28.6 percent of costs for the six chronic conditions studied and vary significantly; (2) reducing PACs to the second decile level would save U.S.$116.7 million in this population; (3) current literature suggests that practices in certain settings could decrease PACs; and (4) using the Prometheus model could create a large potential incentive for a prototypical practice to reduce PACs. Conclusions By extrapolating these findings we conclude that costs might be reduced through payment reform efforts. A full extrapolation of these results, while speculative, suggests that total costs associated to the six chronic conditions studied could decrease by 3.8 percent. PMID:20662949

Asymmetrical Capacitors for Propulsion

NASA Technical Reports Server (NTRS)

Canning, Francis X.; Melcher, Cory; Winet, Edwin

2004-01-01

Asymmetrical Capacitor Thrusters have been proposed as a source of propulsion. For over eighty years, it has been known that a thrust results when a high voltage is placed across an asymmetrical capacitor, when that voltage causes a leakage current to flow. However, there is surprisingly little experimental or theoretical data explaining this effect. This paper reports on the results of tests of several Asymmetrical Capacitor Thrusters (ACTs). The thrust they produce has been measured for various voltages, polarities, and ground configurations and their radiation in the VHF range has been recorded. These tests were performed at atmospheric pressure and at various reduced pressures. A simple model for the thrust was developed. The model assumed the thrust was due to electrostatic forces on the leakage current flowing across the capacitor. It was further assumed that this current involves charged ions which undergo multiple collisions with air. These collisions transfer momentum. All of the measured data was consistent with this model. Many configurations were tested, and the results suggest general design principles for ACTs to be used for a variety of purposes.

A Review and Analysis of Remote Sensing Capability for Air Quality Measurements as a Potential Decision Support Tool Conducted by the NASA DEVELOP Program

NASA Technical Reports Server (NTRS)

Ross, A.; Richards, A.; Keith, K.; Frew, C.; Boseck, J.; Sutton, S.; Watts, C.; Rickman, D.

2007-01-01

This project focused on a comprehensive utilization of air quality model products as decision support tools (DST) needed for public health applications. A review of past and future air quality measurement methods and their uncertainty, along with the relationship of air quality to national and global public health, is vital. This project described current and future NASA satellite remote sensing and ground sensing capabilities and the potential for using these sensors to enhance the prediction, prevention, and control of public health effects that result from poor air quality. The qualitative uncertainty of current satellite remotely sensed air quality, the ground-based remotely sensed air quality, the air quality/public health model, and the decision making process is evaluated in this study. Current peer-reviewed literature suggests that remotely sensed air quality parameters correlate well with ground-based sensor data. A satellite remote-sensed and ground-sensed data complement is needed to enhance the models/tools used by policy makers for the protection of national and global public health communities

Current Perspectives on the Cerebellum and Reading Development.

PubMed

Alvarez, Travis A; Fiez, Julie A

2018-05-03

The dominant neural models of typical and atypical reading focus on the cerebral cortex. However, Nicolson et al. (2001) proposed a model, the cerebellar deficit hypothesis, in which the cerebellum plays an important role in reading. To evaluate the evidence in support of this model, we qualitatively review the current literature and employ meta-analytic tools examining patterns of functional connectivity between the cerebellum and the cerebral reading network. We find evidence for a phonological circuit with connectivity between the cerebellum and a dorsal fronto-parietal pathway, and a semantic circuit with cerebellar connectivity to a ventral fronto-temporal pathway. Furthermore, both cerebral pathways have functional connections with the mid-fusiform gyrus, a region implicated in orthographic processing. Consideration of these circuits within the context of the current literature suggests the cerebellum is positioned to influence both phonological and word-based decoding procedures for recognizing unfamiliar printed words. Overall, multiple lines of research provide support for the cerebellar deficit hypothesis, while also highlighting the need for further research to test mechanistic hypotheses. Copyright © 2018. Published by Elsevier Ltd.

Modeling the relationship between family home environment factors and parental health.

PubMed

Didericksen, Katharine Wickel; Berge, Jerica M

2015-06-01

Understanding parental health is an important part of understanding family health. Previous research suggests that family meals, familial relationship satisfaction, and family physical activity may separately be related to physical health. The current study aims to combine these variables into a structural equation model to determine the collective relationship they have with adult health within a sample of parents (n = 1,435). Most parents were married, White, and highly educated. The relationship between family meals and parental health was significant (β = -.07, t = -2.29, p < .05), with the full model having adequate fit and accounting for some of the overall variance in parental health. Familial relationship satisfaction and family physical activity were not found to be associated with parental health. Exploratory findings of the sample stratified by biological sex are described. Findings from the current study were consistent with a systemic perspective in that parents may have health benefits when they participate in family-level behavior (e.g., family meals). Additional areas for research and limitations to the current study are also discussed. (c) 2015 APA, all rights reserved).

Fluctuation between grandiose and vulnerable narcissism.

PubMed

Gore, Whitney L; Widiger, Thomas A

2016-10-01

Current literature on narcissistic personality disorder has emphasized a distinction between grandiose and vulnerable narcissism. Some researchers have further suggested that narcissistic persons fluctuate between grandiose and vulnerable narcissism. However, this perception has been confined largely to clinical experience with no systematic research testing the hypothesis. Clinicians and clinical psychology professors in the current study identified 143 persons who fit a description of either a grandiose or a vulnerable narcissist and indicated the extent to which these persons ever demonstrated traits of the complementary variant. The results supported the fluctuation hypothesis, particularly for episodes of vulnerable narcissism in persons identified as a grandiose narcissist. Correlations of the grandiose and vulnerable narcissism traits with a brief five-factor model measure corroborated past trait descriptions of the 2 respective variants of narcissism. The results of the current study are compared with existing cross-sectional and longitudinal research, and suggestions for future research are provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Power Laws from Linear Neuronal Cable Theory: Power Spectral Densities of the Soma Potential, Soma Membrane Current and Single-Neuron Contribution to the EEG

PubMed Central

Pettersen, Klas H.; Lindén, Henrik; Tetzlaff, Tom; Einevoll, Gaute T.

2014-01-01

Power laws, that is, power spectral densities (PSDs) exhibiting behavior for large frequencies f, have been observed both in microscopic (neural membrane potentials and currents) and macroscopic (electroencephalography; EEG) recordings. While complex network behavior has been suggested to be at the root of this phenomenon, we here demonstrate a possible origin of such power laws in the biophysical properties of single neurons described by the standard cable equation. Taking advantage of the analytical tractability of the so called ball and stick neuron model, we derive general expressions for the PSD transfer functions for a set of measures of neuronal activity: the soma membrane current, the current-dipole moment (corresponding to the single-neuron EEG contribution), and the soma membrane potential. These PSD transfer functions relate the PSDs of the respective measurements to the PSDs of the noisy input currents. With homogeneously distributed input currents across the neuronal membrane we find that all PSD transfer functions express asymptotic high-frequency power laws with power-law exponents analytically identified as for the soma membrane current, for the current-dipole moment, and for the soma membrane potential. Comparison with available data suggests that the apparent power laws observed in the high-frequency end of the PSD spectra may stem from uncorrelated current sources which are homogeneously distributed across the neural membranes and themselves exhibit pink () noise distributions. While the PSD noise spectra at low frequencies may be dominated by synaptic noise, our findings suggest that the high-frequency power laws may originate in noise from intrinsic ion channels. The significance of this finding goes beyond neuroscience as it demonstrates how power laws with a wide range of values for the power-law exponent α may arise from a simple, linear partial differential equation. PMID:25393030

Power laws from linear neuronal cable theory: power spectral densities of the soma potential, soma membrane current and single-neuron contribution to the EEG.

PubMed

Pettersen, Klas H; Lindén, Henrik; Tetzlaff, Tom; Einevoll, Gaute T

2014-11-01

Power laws, that is, power spectral densities (PSDs) exhibiting 1/f(α) behavior for large frequencies f, have been observed both in microscopic (neural membrane potentials and currents) and macroscopic (electroencephalography; EEG) recordings. While complex network behavior has been suggested to be at the root of this phenomenon, we here demonstrate a possible origin of such power laws in the biophysical properties of single neurons described by the standard cable equation. Taking advantage of the analytical tractability of the so called ball and stick neuron model, we derive general expressions for the PSD transfer functions for a set of measures of neuronal activity: the soma membrane current, the current-dipole moment (corresponding to the single-neuron EEG contribution), and the soma membrane potential. These PSD transfer functions relate the PSDs of the respective measurements to the PSDs of the noisy input currents. With homogeneously distributed input currents across the neuronal membrane we find that all PSD transfer functions express asymptotic high-frequency 1/f(α) power laws with power-law exponents analytically identified as α∞(I) = 1/2 for the soma membrane current, α∞(p) = 3/2 for the current-dipole moment, and α∞(V) = 2 for the soma membrane potential. Comparison with available data suggests that the apparent power laws observed in the high-frequency end of the PSD spectra may stem from uncorrelated current sources which are homogeneously distributed across the neural membranes and themselves exhibit pink (1/f) noise distributions. While the PSD noise spectra at low frequencies may be dominated by synaptic noise, our findings suggest that the high-frequency power laws may originate in noise from intrinsic ion channels. The significance of this finding goes beyond neuroscience as it demonstrates how 1/f(α) power laws with a wide range of values for the power-law exponent α may arise from a simple, linear partial differential equation.

Maternal hypothyroidism: An overview of current experimental models.

PubMed

Ghanbari, Mahboubeh; Ghasemi, Asghar

2017-10-15

Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. To obtain comparable results with different clinical conditions, which lead to MH in humans, several factors have been suggested for researchers to consider before designing the experimental models. Regarding development of fetal body systems during pregnancy, interference at different times provides different results and the appropriate time for induction of hypothyroidism should be selected based on accurate time of development of the system under assessment. Other factors that should be taken into consideration include, physiological and biochemical differences between humans and other species, thyroid hormone-independent effects of anti-thyroid drugs, circadian rhythms in TSH secretion, sex differences, physical and psychological stress. This review addresses essential guidelines for selecting and managing the optimal animal model for MH as well as discussing the pros and cons of currently used models. Copyright © 2017 Elsevier Inc. All rights reserved.

Lexical is as lexical does: computational approaches to lexical representation

PubMed Central

Woollams, Anna M.

2015-01-01

In much of neuroimaging and neuropsychology, regions of the brain have been associated with ‘lexical representation’, with little consideration as to what this cognitive construct actually denotes. Within current computational models of word recognition, there are a number of different approaches to the representation of lexical knowledge. Structural lexical representations, found in original theories of word recognition, have been instantiated in modern localist models. However, such a representational scheme lacks neural plausibility in terms of economy and flexibility. Connectionist models have therefore adopted distributed representations of form and meaning. Semantic representations in connectionist models necessarily encode lexical knowledge. Yet when equipped with recurrent connections, connectionist models can also develop attractors for familiar forms that function as lexical representations. Current behavioural, neuropsychological and neuroimaging evidence shows a clear role for semantic information, but also suggests some modality- and task-specific lexical representations. A variety of connectionist architectures could implement these distributed functional representations, and further experimental and simulation work is required to discriminate between these alternatives. Future conceptualisations of lexical representations will therefore emerge from a synergy between modelling and neuroscience. PMID:25893204

On the need and use of models to explore the role of economic confidence:a survey.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sprigg, James A.; Paez, Paul J.; Hand, Michael S.

2005-04-01

Empirical studies suggest that consumption is more sensitive to current income than suggested under the permanent income hypothesis, which raises questions regarding expectations for future income, risk aversion, and the role of economic confidence measures. This report surveys a body of fundamental economic literature as well as burgeoning computational modeling methods to support efforts to better anticipate cascading economic responses to terrorist threats and attacks. This is a three part survey to support the incorporation of models of economic confidence into agent-based microeconomic simulations. We first review broad underlying economic principles related to this topic. We then review the economicmore » principle of confidence and related empirical studies. Finally, we provide a brief survey of efforts and publications related to agent-based economic simulation.« less

The Role of Economic Strain on Adolescent Delinquency: A Microsocial Process Model

PubMed Central

Low, Sabina; Sinclair, Ryan; Shortt, Joann Wu

2013-01-01

The current study examines the role of economic strain as a moderator of the microsocial processes influencing younger siblings’ delinquency (externalizing behavior and substance use) in a longitudinal design. The younger siblings (122 younger brothers and 122 younger sisters) were from 244 families with same-sex biological siblings. Structural equation modeling was utilized to examine a process model whereby mothers’ harsh/inconsistent parenting and older sibling delinquency influence younger siblings’ delinquent behavior via sibling aggression and delinquent peer affiliation. Findings suggest that indirect mechanisms vary as a function of economic strain, with sibling aggression having a stronger, more detrimental effect on adolescent delinquency in economically strained families. Data suggest that familial economic conditions contextualize the relative roles of parenting, sibling, and peer processes in the transmission of risk to adolescent delinquency. PMID:22709262

DOE Office of Scientific and Technical Information (OSTI.GOV)

Altsybeyev, V.V., E-mail: v.altsybeev@spbu.ru; Ponomarev, V.A.

The particle tracking method with a so-called gun iteration for modeling the space charge is discussed in the following paper. We suggest to apply the emission model based on the Gauss's law for the calculation of the space charge limited current density distribution using considered method. Based on the presented emission model we have developed a numerical algorithm for this calculations. This approach allows us to perform accurate and low time consumpting numerical simulations for different vacuum sources with the curved emitting surfaces and also in the presence of additional physical effects such as bipolar flows and backscattered electrons. Themore » results of the simulations of the cylindrical diode and diode with elliptical emitter with the use of axysimmetric coordinates are presented. The high efficiency and accuracy of the suggested approach are confirmed by the obtained results and comparisons with the analytical solutions.« less

Friendship, perceived mattering and happiness: a study of American and Turkish college students.

PubMed

Demir, Melikşah; Ozen, Ayça; Doğan, Aysun

2012-01-01

Although it is well established that friendship is a consistent correlate of happiness, less is known about how friendship experiences might promote happiness. The current investigation addressed this gap by testing a mediational model proposing that perceived mattering explains the association of friendship quality with happiness among college students in Turkey and the United States. An alternative model suggesting friendship quality as the mediator was also tested to enhance confidence in the proposed model. SEM analyses revealed that perceived mattering mediated the association of friendship with happiness only in the American sample. In the Turkish sample, friendship quality mediated the association between mattering and happiness. Findings highlight the importance of cross-cultural research and suggest that the underlying processes and psychological mechanisms related to the friendship-happiness link might be different in different cultures.

The Effects of Multiple Intelligence Teaching Strategies on Achievement in Reading and Mathematics

ERIC Educational Resources Information Center

Harriman, Vanessa

2010-01-01

Today's educators must use research-based teaching strategies that increase achievement levels of students. Howard Gardner's Theory of Multiple Intelligences is scientifically-based. The current model suggests eight different areas in which a person can demonstrate intelligence. This study compared reading and math assessments score of elementary…

Identification of defense-related genes newly-associated with tomato flower abscission

USDA-ARS?s Scientific Manuscript database

The current abscission model suggests the formation of a post-abscission trans-differentiation of a protective layer as the last step of the process. The present report expands the repertoire of genes activated in the tomato flower abscission zone (AZ), which are likely to be involved in defense res...

Does Student Quality Matter in the Teaching of Economic Principles?

ERIC Educational Resources Information Center

Andreopoulos, Giuliana Campanelli; Panayides, Alexandros

2010-01-01

Economics is usually perceived as a difficult subject among undergraduate students and the literature suggests that the student's problems with principles of economics are mainly related to the chalk and talk type of teaching, the simplicity of economic models, limited discussions on current economic issues, and on race, gender, and other types of…

Lung Cancer Screening May Benefit Those at Highest Risk

Cancer.gov

People at the highest risk for lung cancer, based on a risk model, may be more likely to benefit from screening with low-dose CT, a new analysis suggests. The study authors believe the findings may better define who should undergo lung cancer screening, as this Cancer Currents blog post explains.

A New Formulation of the Ethical Self through Kierkegaard's Notion of Subjectivity: In Search of a New Moral Education.

ERIC Educational Resources Information Center

Kwak, Duck-Joo

2001-01-01

Essay on Kierkegaard's notion of subjectivity in the formulation of the ethical self. Suggests that Kierkegaard's self-reflecting ethical model offers an alternative approach to the teaching of moral education in South Korean schools, currently dominated by a theory-oriented, problem-solving paradigm. (PKP)

Early Math Interest and the Development of Math Skills

ERIC Educational Resources Information Center

Fisher, Paige H.; Dobbs-Oates, Jennifer; Doctoroff, Greta L.; Arnold, David H.

2012-01-01

Prior models suggest that math attitudes and ability might strengthen each other over time in a reciprocal fashion (Ma, 1997). The current study investigated the relationship between math interest and skill both concurrently and over time in a preschool sample. Analyses of concurrent relationships indicated that high levels of interest were…

Testing the Efficacy of Theoretically Derived Improvements in the Treatment of Social Phobia

ERIC Educational Resources Information Center

Rapee, Ronald M.; Gaston, Jonathan E.; Abbott, Maree J.

2009-01-01

Recent theoretical models of social phobia suggest that targeting several specific cognitive factors in treatment should enhance treatment efficacy over that of more traditional skills-based treatment programs. In the current study, 195 people with social phobia were randomly allocated to 1 of 3 treatments: standard cognitive restructuring plus in…

Behavioral and Neurophysiological Correlates of Striatal Dopamine Depletion: A Rodent Model of Parkinson's Disease

ERIC Educational Resources Information Center

Plowman, Emily K.; Kleim, Jeffrey A.

2011-01-01

Both limb and cranial motor functions are adversely impacted by Parkinson's disease (PD). While current pharmacological and surgical interventions are effective in alleviating general limb motor symptoms of PD, they have failed to provide significant benefit for cranial motor functions. This suggests that the neuropathologies mediating limb and…

Secondary Education Students' Difficulties in Algorithmic Problems with Arrays: An Analysis Using the SOLO Taxonomy

ERIC Educational Resources Information Center

Vrachnos, Euripides; Jimoyiannis, Athanassios

2017-01-01

Developing students' algorithmic and computational thinking is currently a major objective for primary and secondary education in many countries around the globe. Literature suggests that students face at various difficulties in programming processes, because of their mental models about basic programming constructs. Arrays constitute the first…

Is Physiology the Locus of Health/Health Promotion?

ERIC Educational Resources Information Center

Zbilut, Joseph P.

2008-01-01

A current trend in physiology education involves the use of clinical vignettes to demonstrate the importance of knowing normal physiology to appreciate pathophysiology. Although laudable, in effect, such tactics promote the so-called "disease" model of medicine while at the same time suggesting that the only utility for the knowledge of physiology…

Improving Science Assessments by Situating Them in a Virtual Environment

ERIC Educational Resources Information Center

Ketelhut, Diane Jass; Nelson, Brian; Schifter, Catherine; Kim, Younsu

2013-01-01

Current science assessments typically present a series of isolated fact-based questions, poorly representing the complexity of how real-world science is constructed. The National Research Council asserts that this needs to change to reflect a more authentic model of science practice. We strongly concur and suggest that good science assessments…

The Influence of Personality, Parenting Styles, and Perfectionism on Performance Goal Orientation in High Ability Students

ERIC Educational Resources Information Center

Miller, Angie L.; Speirs Neumeister, Kristie L.

2017-01-01

The current study explores relationships among gender, perceived parenting style, the personality traits of conscientiousness and neuroticism, perfectionism, and achievement goal orientation in a high ability and high achieving young adult population. Using data from Honors College students at a Midwestern university, a path model suggests that…

Assessing Competition on the Russian University Market Using a Modified Panzar-Rosse Model

ERIC Educational Resources Information Center

Sergeeva, Vladlena Vladimirovna

2016-01-01

This paper reviews some government policy measures aimed at strengthening competition in the Russian university market and looks at the best international practices in this area. It analyzes the competitive behavior of universities under the current government policy on higher education and research and development and suggests an approach to…

Mindfulness and Behavioral Parent Training: Commentary

ERIC Educational Resources Information Center

Eyberg, Sheila M.; Graham-Pole, John R.

2005-01-01

We review the description of mindfulness-based parent training (MBPT) and the argument that mindfulness practice offers a way to bring behavioral parent training (BPT) in line with current empirical knowledge. The strength of the proposed MBPT model is the attention it draws to process issues in BPT. We suggest, however, that it may not be…

Effects of exposure to HZE particles on the cognitive performance of ovariectomized and intact female rats

USDA-ARS?s Scientific Manuscript database

INTRODUCTION It is likely that both male and female astronauts will comprise the crew on exploratory class missions. Despite this, the majority of the research using animal models has utilized male subjects. However, the limited data currently available suggests that the cognitive effects of exposu...

The role of habitat filtering in the leaf economics spectrum and plant susceptibility to pathogen infection

USGS Publications Warehouse

Welsh, Miranda E; Cronin, James P.; Mitchell, Charles E.

2016-01-01

5.Synthesis. Our results suggest that habitat filtering plays a fundamental role in strengthening the trait correlations of the LES, and that trait-based models may be less accurate when communities have not been filtered by the current environment, for example, following rapid environmental change.

The Use of Gestalt Interventions in the Treatment of the Resistant Alcohol-Dependent Client.

ERIC Educational Resources Information Center

Ramey, Luellen

1998-01-01

Reviews ethical and practical dilemmas associated with clients who have hidden alcohol dependencies, and proposes an approach rooted in Gestalt counseling theory which confronts these issues and is compatible with a current emerging alcohol-treatment model. Suggests specific activities for addressing client resistance to revealing a hidden alcohol…

Children and Psychotropic Medication: What Role Should Advocacy Counseling Play? (

ERIC Educational Resources Information Center

Ingersoll, R. Elliott; Bauer, Ann; Burns, Laura

2004-01-01

There are currently millions of children with mental and emotional symptoms who are being treated with psychotropic medication. The authors critique such treatment and suggest that advocacy counseling is a responsible approach to balance the power of both the pharmaceutical companies and the medical model in the mental health arena.

Reengineering Aircraft Structural Life Prediction Using a Digital Twin

DTIC Science & Technology

2011-01-01

that exaflop-per-second computers will become available: “extrapolation of current hardware trends suggests that exascale systems could be available in...vol. 28, no. 5, pp. 339–350, 2002. [4] H. Simon, T. Zacharia, and R. Stevens, Modeling and Sim- ulation at the Exascale for Energy and the Environment

Articulation and the State Foreign Language Association.

ERIC Educational Resources Information Center

Woloshin, David J.

This paper discusses current problems in the teaching of foreign languages, suggests reasons for its present decline, and proposes a program to be developed at the local level which could serve as a model for a state-wide curriculum. After discussing enrollment trends and causes for the lack of articulation in foreign language instruction at all…

Semantic Memory Recognition Is Supported by Intrinsic Recollection-Like Processes: "The Butcher on the Bus" Revisited

ERIC Educational Resources Information Center

Waidergoren, Shani; Segalowicz, Judith; Gilboa, Asaf

2012-01-01

Dual-process models suggest that recognition memory is independently supported by recollection and familiarity. Current theories attribute recollection solely to hippocampally mediated episodic memory (EM), and familiarity to both episodic and semantic memory (SM) supported by medial temporal lobe cortex (MTLC) and prefrontal cortex. We tested…

The Funding of Vocational Education and Training for Students with Disabilities. Volume 2

ERIC Educational Resources Information Center

Smith, Chris Selby; Ferrier, Fran

2004-01-01

This volume is a companion to "The Funding of Vocational Education and Training for Students with Disabilities: Volume 1" [ED495186], which examines how the vocational education and training system currently allocates funds to support students with a disability, and suggests other funding models to promote their participation. The…

Student Interactions in Online Discussion Forum: Empirical Research from "Media Richness Theory" Perspective

ERIC Educational Resources Information Center

Balaji, M. S.; Chakrabarti, Diganta

2010-01-01

The present study contributes to the understanding of the effectiveness of online discussion forum in student learning. A conceptual model based on "theory of online learning" and "media richness theory" was proposed and empirically tested. We extend the current understanding of media richness theory to suggest that use of…

Applying the Job Characteristics Model to the College Education Experience

ERIC Educational Resources Information Center

Kass, Steven J.; Vodanovich, Stephen J.; Khosravi, Jasmine Y.

2011-01-01

Boredom is one of the most common complaints among university students, with studies suggesting its link to poor grades, drop out, and behavioral problems. Principles borrowed from industrial-organizational psychology may help prevent boredom and enrich the classroom experience. In the current study, we applied the core dimensions of the job…

Multi-Level Alignment Model: Transforming Face-to-Face into E-Instructional Programs

ERIC Educational Resources Information Center

Byers, Celina

2005-01-01

Purpose--To suggest to others in the field an approach equally valid for transforming existing courses into online courses and for creating new online courses. Design/methodology/approach--Using the literature for substantiation, this article discusses the current rapid change within organizations, the role of technology in that change, and the…

Automatic Associations and Panic Disorder: Trajectories of Change over the Course of Treatment

ERIC Educational Resources Information Center

Teachman, Bethany A.; Marker, Craig D.; Smith-Janik, Shannan B.

2008-01-01

Cognitive models of anxiety and panic suggest that symptom reduction during treatment should be preceded by changes in cognitive processing, including modifying the anxious schema. The current study tested these hypotheses by using a repeated measures design to evaluate whether the trajectory of change in automatic panic associations over a…

Procrastination, Self-Esteem, Academic Performance, and Well-Being: A Moderated Mediation Model

ERIC Educational Resources Information Center

Duru, Erdinç; Balkis, Murat

2017-01-01

The current study attempts to examine integrated effects of procrastination, self-esteem, and academic performance on well-being in a sample of Turkish undergraduate students (N = 348). Results confirm prior evidence suggesting that procrastination and self-esteem were important predictors of well-being. Results also indicated that both…

State Alcohol Advertising Laws: Current Status and Model Policies.

ERIC Educational Resources Information Center

2003

The concern about alcohol marketing and underage drinking has been heightened by recent findings in the scientific research community. Studies have established that alcohol advertising exposure influences a young person's beliefs about alcohol and his/her intention to drink. They also suggest that advertising may have a direct impact on youth…

For the Primacy of Speech Communication in Organizational Communication.

ERIC Educational Resources Information Center

Salem, Philip

Based on a review of all organizational communication research published in 33 professional journals between 1966 and 1978, this essay describes the current status of the investigation of organizational communication. The first part of the essay is organized around Elwood Murray's model of a discipline and employs the typologies suggested by G.…

Critical Review on Power in Organization: Empowerment in Human Resource Development

ERIC Educational Resources Information Center

Jo, Sung Jun; Park, Sunyoung

2016-01-01

Purpose: This paper aims to analyze current practices, discuss empowerment from the theoretical perspectives on power in organizations and suggest an empowerment model based on the type of organizational culture and the role of human resource development (HRD). Design/methodology/approach: By reviewing the classic viewpoint of power, Lukes'…

Could natural selection change the geographic range limits of light brown apple moth (Lepidoptera, Tortricidae) in North America?

Treesearch

Amy C. Morey; Robert C. Venette; William D. Hutchison

2013-01-01

We artificially selected for increased freeze tolerance in the invasive light brown apple moth. Our results suggest that, by not accounting for adaptation to cold, current models of potential geographic distributions could underestimate the areas at risk of exposure to this species.

THE MOVEMENT SYSTEM IN EDUCATION.

PubMed

Hoogenboom, Barbara J; Sulavik, Mark

2017-11-01

Although many physical therapists have begun to focus on movement and function in clinical practice, a significant number continue to focus on impairments or pathoanatomic models to direct interventions. This paradigm may be driven by the current models used to direct and guide curricula used for physical therapist education. The methods by which students are educated may contribute to a focus on independent systems, rather than viewing the body as a functional whole. Students who enter practice must be able to integrate information across multiple systems that affect a patient or client's movement and function. Such integration must be taught to students and it is the responsibility of those in physical therapist education to embrace and teach the next generation of students this identifying professional paradigm of the movement system. The purpose of this clinical commentary is to describe the current state of the movement system in physical therapy education, suggest strategies for enhancing movement system focus in entry level education, and envision the future of physical therapy education related to the movement system. Contributions by a student author offer depth and perspective to the ideas and suggestions presented. 5.

Is the Sense of Agency in Schizophrenia Influenced by Resting-State Variation in Self-Referential Regions of the Brain?

PubMed Central

Wagner, Nils-Frederic; Northoff, Georg

2016-01-01

Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further this line of inquiry by suggesting that ongoing neurological activity (the brain’s resting state) in self-referential regions of the brain can provide a deeper level of influence beyond what the current models capture. Based on neuroimaging studies, we suggest that aberrant activity in regions such as the default mode network of individuals with schizophrenia can lead to a misattribution of internally/externally generated stimuli. This can result in symptoms such as thought insertion and delusions of control. Consequently, neuroimaging can contribute to a more comprehensive conceptualization and measurement of agency and potential treatment implications. PMID:26221048

ORCHIDEE-MICT (v8.4.1), a land surface model for the high latitudes: model description and validation

NASA Astrophysics Data System (ADS)

Guimberteau, Matthieu; Zhu, Dan; Maignan, Fabienne; Huang, Ye; Yue, Chao; Dantec-Nédélec, Sarah; Ottlé, Catherine; Jornet-Puig, Albert; Bastos, Ana; Laurent, Pierre; Goll, Daniel; Bowring, Simon; Chang, Jinfeng; Guenet, Bertrand; Tifafi, Marwa; Peng, Shushi; Krinner, Gerhard; Ducharne, Agnès; Wang, Fuxing; Wang, Tao; Wang, Xuhui; Wang, Yilong; Yin, Zun; Lauerwald, Ronny; Joetzjer, Emilie; Qiu, Chunjing; Kim, Hyungjun; Ciais, Philippe

2018-01-01

The high-latitude regions of the Northern Hemisphere are a nexus for the interaction between land surface physical properties and their exchange of carbon and energy with the atmosphere. At these latitudes, two carbon pools of planetary significance - those of the permanently frozen soils (permafrost), and of the great expanse of boreal forest - are vulnerable to destabilization in the face of currently observed climatic warming, the speed and intensity of which are expected to increase with time. Improved projections of future Arctic and boreal ecosystem transformation require improved land surface models that integrate processes specific to these cold biomes. To this end, this study lays out relevant new parameterizations in the ORCHIDEE-MICT land surface model. These describe the interactions between soil carbon, soil temperature and hydrology, and their resulting feedbacks on water and CO2 fluxes, in addition to a recently developed fire module. Outputs from ORCHIDEE-MICT, when forced by two climate input datasets, are extensively evaluated against (i) temperature gradients between the atmosphere and deep soils, (ii) the hydrological components comprising the water balance of the largest high-latitude basins, and (iii) CO2 flux and carbon stock observations. The model performance is good with respect to empirical data, despite a simulated excessive plant water stress and a positive land surface temperature bias. In addition, acute model sensitivity to the choice of input forcing data suggests that the calibration of model parameters is strongly forcing-dependent. Overall, we suggest that this new model design is at the forefront of current efforts to reliably estimate future perturbations to the high-latitude terrestrial environment.

A feedback model of visual attention.

PubMed

Spratling, M W; Johnson, M H

2004-03-01

Feedback connections are a prominent feature of cortical anatomy and are likely to have a significant functional role in neural information processing. We present a neural network model of cortical feedback that successfully simulates neurophysiological data associated with attention. In this domain, our model can be considered a more detailed, and biologically plausible, implementation of the biased competition model of attention. However, our model is more general as it can also explain a variety of other top-down processes in vision, such as figure/ground segmentation and contextual cueing. This model thus suggests that a common mechanism, involving cortical feedback pathways, is responsible for a range of phenomena and provides a unified account of currently disparate areas of research.

Ion transport and loss in the Earth's quiet ring current. 2: Diffusion and magnetosphere-ionosphere coupling

NASA Technical Reports Server (NTRS)

Sheldon, R. B.

1994-01-01

We have studied the transport and loss of H(+), He(+), and He(++) ions in the Earth's quiet time ring current (1 to 300 keV/e, 3 to 7 R(sub E), Kp less than 2+, absolute value of Dst less than 11, 70 to 110 degs pitchangles, all LT) comparing the standard radial diffusion model developed for the higher-energy radiation belt particles with measurements of the lower energy ring current ions in a previous paper. Large deviations of that model, which fit only 50% of the data to within a factor of 10, suggested that another transport mechanism is operating in the ring current. Here we derive a modified diffusion coefficient corrected for electric field effects on ring current energy ions that fit nearly 80% of the data to within a factor of 2. Thus we infer that electric field fluctuations from the low-latitude to midlatitude ionosphere (ionospheric dynamo) dominated the ring current transport, rather than high-latitude or solar wind fluctuations. Much of the remaining deviation may arise from convective electric field transport of the E less than 30 keV particles. Since convection effects cannot be correctly treated with this azimuthally symmetric model, we defer treatment of the lowest-energy ions to a another paper. We give chi(exp 2) contours for the best fit, showing the dependence of the fit upon the internal/external spectral power of the predicted electric and magnetic field fluctuations.

Strategic model of national rabies control in Korea.

PubMed

Cheong, Yeotaek; Kim, Bongjun; Lee, Ki Joong; Park, Donghwa; Kim, Sooyeon; Kim, Hyeoncheol; Park, Eunyeon; Lee, Hyeongchan; Bae, Chaewun; Oh, Changin; Park, Seung-Yong; Song, Chang-Seon; Lee, Sang-Won; Choi, In-Soo; Lee, Joong-Bok

2014-01-01

Rabies is an important zoonosis in the public and veterinary healthy arenas. This article provides information on the situation of current rabies outbreak, analyzes the current national rabies control system, reviews the weaknesses of the national rabies control strategy, and identifies an appropriate solution to manage the current situation. Current rabies outbreak was shown to be present from rural areas to urban regions. Moreover, the situation worldwide demonstrates that each nation struggles to prevent or control rabies. Proper application and execution of the rabies control program require the overcoming of existing weaknesses. Bait vaccines and other complex programs are suggested to prevent rabies transmission or infection. Acceleration of the rabies control strategy also requires supplementation of current policy and of public information. In addition, these prevention strategies should be executed over a mid- to long-term period to control rabies.

Computational Reconstruction of Pacemaking and Intrinsic Electroresponsiveness in Cerebellar Golgi Cells

PubMed Central

Solinas, Sergio; Forti, Lia; Cesana, Elisabetta; Mapelli, Jonathan; De Schutter, Erik; D'Angelo, Egidio

2007-01-01

The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711–729). Four main currents were shown to be involved, namely a persistent sodium current (I Na-p), an h current (I h), an SK-type calcium-dependent potassium current (I K-AHP), and a slow M-like potassium current (I K-slow). These ionic currents could take part, together with others, also to different aspects of neuronal excitability like responses to depolarizing and hyperpolarizing current injection. However, the ionic mechanisms and their interactions remained largely hypothetical. In this work, we have investigated the mechanisms of Golgi cell excitability by developing a computational model. The model predicts that pacemaking is sustained by subthreshold oscillations tightly coupled to spikes. I Na-p and I K-slow emerged as the critical determinants of oscillations. I h also played a role by setting the oscillatory mechanism into the appropriate membrane potential range. I K-AHP, though taking part to the oscillation, appeared primarily involved in regulating the ISI following spikes. The combination with other currents, in particular a resurgent sodium current (I Na-r) and an A-current (I K-A), allowed a precise regulation of response frequency and delay. These results provide a coherent reconstruction of the ionic mechanisms determining Golgi cell intrinsic electroresponsiveness and suggests important implications for cerebellar signal processing, which will be fully developed in a companion paper (Solinas et al., 2008. Front. Neurosci. 2:4). PMID:18946520

Suggestions for Forest Conservation Policy under Climate Change

NASA Astrophysics Data System (ADS)

Choe, H.; Thorne, J. H.; Lee, D. K.; Seo, C.

2015-12-01

Climate change and the destruction of natural habitats by land-use change are two main factors in decreasing terrestrial biodiversity. Studying land-use and climate change and their impact under different scenarios can help suggest policy directions for future events. This study explores the spatial results of different land use and climate models on the extent of species rich areas in South Korea. We built land use models of forest conversion and created four 2050 scenarios: (1) a loss trend following current levels, resulting in 15.5% lost; (2) similar loss, but with forest conservation in areas with suitable future climates; (3) a reduction of forest loss by 50%; and (4) a combination of preservation of forest climate refugia and overall reduction of loss by 50%. Forest climate refugia were identified through the use of species distribution models run on 1,031 forest plant species to project current and 2050 distributions. We calculated change in species richness under four climate projections, permitting an assessment of forest refugia zones. We then crossed the four land use models with the climate-driven change in species richness. Forest areas predominantly convert to agricultural areas, while climate-suitable extents for forest plants decline and move northward, especially to higher elevations. Scenario 2, that has the higher level of deforestation but protects future species rich areas, conserves nearly as much future biodiversity as scenario 3, which reduced deforestation rates by 50%. This points to the importance of including biogeographic climate dynamics in forest policy. Scenario 4 was the most effective at conserving forest biodiversity. We suggest conserving forest areas with suitable climates for biodiversity conservation and the establishment of monoculture plantations targeted to areas where species richness will decline based on our results.

Response of the Milky Way's disc to the Large Magellanic Cloud in a first infall scenario

NASA Astrophysics Data System (ADS)

Laporte, Chervin F. P.; Gómez, Facundo A.; Besla, Gurtina; Johnston, Kathryn V.; Garavito-Camargo, Nicolas

2018-01-01

We present N-body and hydrodynamical simulations of the response of the Milky Way's baryonic disc to the presence of the Large Magellanic Cloud during a first infall scenario. For a fiducial Galactic model reproducing the gross properties of the Galaxy, we explore a set of six initial conditions for the Large Magellanic Cloud (LMC) of varying mass which all evolve to fit the measured constraints on its current position and velocity with respect to the Galactic Centre. We find that the LMC can produce strong disturbances - warping of the stellar and gaseous discs - in the Galaxy, without violating constraints from the phase-space distribution of stars in the Solar Neighbourhood. All models correctly reproduce the phases of the warp and its antisymmetrical shape about the disc's mid-plane. If the warp is due to the LMC alone, then the largest mass model is favoured (2.5 × 1011 M⊙). Still, some quantitative discrepancies remain, including deficits in height of ΔZ = 0.7 kpc at R = 22 kpc and ΔZ = 0.7 kpc at R = 16 kpc. This suggests that even higher infall masses for the LMC's halo are allowed by the data. A comparison with the vertical perturbations induced by a heavy Sagittarius dSph model (1011 M⊙) suggest that positive interference with the LMC warp is expected at R = 16 kpc. We conclude that the vertical structure of the Galactic disc beyond the Solar Neighbourhood may jointly be shaped by its most massive satellites. As such, the current structure of the Milky Way suggests we are seeing the process of disc heating by satellite interactions in action.

An interacting spin-flip model for one-dimensional proton conduction

NASA Astrophysics Data System (ADS)

Chou, Tom

2002-05-01

A discrete asymmetric exclusion process (ASEP) is developed to model proton conduction along one-dimensional water wires. Each lattice site represents a water molecule that can be in only one of three states; protonated, left-pointing and right-pointing. Only a right- (left-) pointing water can accept a proton from its left (). Results of asymptotic mean field analysis and Monte Carlo simulations for the three-species, open boundary exclusion model are presented and compared. The mean field results for the steady-state proton current suggest a number of regimes analogous to the low and maximal current phases found in the single-species ASEP (Derrida B 1998 Phys. Rep. 301 65-83). We find that the mean field results are accurate (compared with lattice Monte Carlo simulations) only in certain regimes. Refinements and extensions including more elaborate forces and pore defects are also discussed.

Permanent human occupation of the central Tibetan Plateau in the early Holocene.

PubMed

Meyer, M C; Aldenderfer, M S; Wang, Z; Hoffmann, D L; Dahl, J A; Degering, D; Haas, W R; Schlütz, F

2017-01-06

Current models of the peopling of the higher-elevation zones of the Tibetan Plateau postulate that permanent occupation could only have been facilitated by an agricultural lifeway at ~3.6 thousand calibrated carbon-14 years before present. Here we report a reanalysis of the chronology of the Chusang site, located on the central Tibetan Plateau at an elevation of ~4270 meters above sea level. The minimum age of the site is fixed at ~7.4 thousand years (thorium-230/uranium dating), with a maximum age between ~8.20 and 12.67 thousand calibrated carbon-14 years before present (carbon-14 assays). Travel cost modeling and archaeological data suggest that the site was part of an annual, permanent, preagricultural occupation of the central plateau. These findings challenge current models of the occupation of the Tibetan Plateau. Copyright © 2017, American Association for the Advancement of Science.

Modeling of Mutiscale Electromagnetic Magnetosphere-Ionosphere Interactions near Discrete Auroral Arcs Observed by the MICA Sounding Rocket

NASA Astrophysics Data System (ADS)

Streltsov, A. V.; Lynch, K. A.; Fernandes, P. A.; Miceli, R.; Hampton, D. L.; Michell, R. G.; Samara, M.

2012-12-01

The MICA (Magnetosphere-Ionosphere Coupling in the Alfvén Resonator) sounding rocket was launched from Poker Flat on February 19, 2012. The rocket was aimed into the system of discrete auroral arcs and during its flight it detected small-scale electromagnetic disturbances with characteristic features of dispersive Alfvén waves. We report results from numerical modeling of these observations. Our simulations are based on a two-fluid MHD model describing multi-scale interactions between magnetic field-aligned currents carried by shear Alfven waves and the ionosphere. The results from our simulations suggest that the small-scale electromagnetic structures measured by MICA indeed can be interpreted as dispersive Alfvén waves generated by the active ionospheric response (ionopspheric feedback instability) inside the large-scale downward magnetic field-aligned current interacting with the ionosphere.

The Food Marketing Defense Model: Integrating Psychological Research to Protect Youth and Inform Public Policy.

PubMed

Harris, Jennifer L; Brownell, Kelly D; Bargh, John A

2009-12-01

Marketing practices that promote calorie-dense, nutrient-poor foods directly to children and adolescents present significant public health risk. Worldwide, calls for government action and industry change to protect young people from the negative effects of food marketing have increased. Current proposals focus on restricting television advertising to children under 12 years old, but current psychological models suggest that much more is required. All forms of marketing pose considerable risk; adolescents are also highly vulnerable; and food marketing may produce far-reaching negative health outcomes. We propose a food marketing defense model that posits four necessary conditions to effectively counter harmful food marketing practices: awareness, understanding, ability and motivation to resist. A new generation of psychological research is needed to examine each of these processes, including the psychological mechanisms through which food marketing affects young people, to identify public policy that will effectively protect them from harmful influence.

Obtaining environmental measures to facilitate vertebrate habitat modeling

USGS Publications Warehouse

Karl, J.W.; Wright, N.M.; Heglund, P.J.; Scott, J.M.

1999-01-01

Published literature generally lacks habitat information needed to adequately model the habitats of most wildlife species at large scales (>1:100,000). We searched in primary and secondary literature for occurrence of several potentially useful habitat measures for 20 species of interest to the Idaho Department of Fish and Game. We found adequate information for modeling only the habitats of certain game species and species of special interest. We suggest that many more researchers could collect simple habitat information regarding vegetation composition and structure, topographic features, soils, temperature, and distance to special landscape features such that current research expenses would not be increased significantly. We recommend that habitat data be consistently reported in peer-reviewed literature or deposited into a central data repository. This will not only help fill the gaps in our current knowledge of wildlife but also place it in a format that is readily accessible by the scientific community.

Examining the Pathologic Adaptation Model of Community Violence Exposure in Male Adolescents of Color

PubMed Central

Gaylord-Harden, Noni K.; So, Suzanna; Bai, Grace J.; Henry, David B.; Tolan, Patrick H.

2017-01-01

The current study examined a model of desensitization to community violence exposure—the pathologic adaptation model—in male adolescents of color. The current study included 285 African American (61%) and Latino (39%) male adolescents (W1 M age = 12.41) from the Chicago Youth Development Study to examine the longitudinal associations between community violence exposure, depressive symptoms, and violent behavior. Consistent with the pathologic adaptation model, results indicated a linear, positive association between community violence exposure in middle adolescence and violent behavior in late adolescence, as well as a curvilinear association between community violence exposure in middle adolescence and depressive symptoms in late adolescence, suggesting emotional desensitization. Further, these effects were specific to cognitive-affective symptoms of depression and not somatic symptoms. Emotional desensitization outcomes, as assessed by depressive symptoms, can occur in male adolescents of color exposed to community violence and these effects extend from middle adolescence to late adolescence. PMID:27653968

The Food Marketing Defense Model: Integrating Psychological Research to Protect Youth and Inform Public Policy

PubMed Central

Harris, Jennifer L.; Brownell, Kelly D.; Bargh, John A.

2009-01-01

Marketing practices that promote calorie-dense, nutrient-poor foods directly to children and adolescents present significant public health risk. Worldwide, calls for government action and industry change to protect young people from the negative effects of food marketing have increased. Current proposals focus on restricting television advertising to children under 12 years old, but current psychological models suggest that much more is required. All forms of marketing pose considerable risk; adolescents are also highly vulnerable; and food marketing may produce far-reaching negative health outcomes. We propose a food marketing defense model that posits four necessary conditions to effectively counter harmful food marketing practices: awareness, understanding, ability and motivation to resist. A new generation of psychological research is needed to examine each of these processes, including the psychological mechanisms through which food marketing affects young people, to identify public policy that will effectively protect them from harmful influence. PMID:20182647

A phenomenological model of solar flares

NASA Technical Reports Server (NTRS)

Colgate, S. A.

1978-01-01

The energy of solar flares is derived from the magnetic energy of fields convected to the sun's surface and subsequently converted to heat and energetic particles within the chromosphere. The circumstances of this conversion in most current models is magnetic flux annihilation at a neutral sheet. An analysis is conducted of the constraints of flux annihilation. It is shown that the present evidence of solar cosmic rays, X-rays, gamma-rays, and total energy suggests a choice of annihilation not at a neutral point, but by an enhanced dissipation of a field-aligned current. The field configuration is related both to its origin and to the extensive theory and laboratory experiments concerned with this configuration in magnetic fusion. The magnetic field model is applied to the August 4 flare. It is shown how the plasma heating in the annihilation region balanced by thermal conduction leads to a plasma temperature of about 20 million deg K.

German EstSmoke: estimating adult smoking-related costs and consequences of smoking cessation for Germany.

PubMed

Sonntag, Diana; Gilbody, Simon; Winkler, Volker; Ali, Shehzad

2018-01-01

We compared predicted life-time health-care costs for current, never and ex-smokers in Germany under the current set of tobacco control polices. We compared these economic consequences of the current situation with an alternative in which Germany were to implement more comprehensive tobacco control policies consistent with the World Health Organization (WHO) Framework Convention for Tobacco Control (FCTC) guidelines. German EstSmoke, an adapted version of the UK EstSmoke simulation model, applies the Markov modelling approach. Transition probabilities for (re-)currence of smoking-related diseases were calculated from large German disease-specific registries and the German Health Update (GEDA 2010). Estimations of both health-care costs and effect sizes of smoking cessation policies were taken from recent German studies and discounted at 3.5%/year. Germany. German population of prevalent current, never and ex-smokers in 2009. Life-time cost and outcomes in current, never and ex-smokers. If tobacco control policies are not strengthened, the German smoking population will incur €41.56 billion life-time excess costs compared with never smokers. Implementing tobacco control policies consistent with WHO FCTC guidelines would reduce the difference of life-time costs between current smokers and ex-smokers by at least €1.7 billion. Modelling suggests that the life-time healthcare costs of people in Germany who smoke are substantially greater than those of people who have never smoked. However, more comprehensive tobacco control policies could reduce health-care expenditures for current smokers by at least 4%. © 2017 Society for the Study of Addiction.

Missing iris effect as a possible cause of muted hydrological change and high climate sensitivity in models

NASA Astrophysics Data System (ADS)

Mauritsen, Thorsten; Stevens, Bjorn

2015-05-01

Equilibrium climate sensitivity to a doubling of CO2 falls between 2.0 and 4.6 K in current climate models, and they suggest a weak increase in global mean precipitation. Inferences from the observational record, however, place climate sensitivity near the lower end of this range and indicate that models underestimate some of the changes in the hydrological cycle. These discrepancies raise the possibility that important feedbacks are missing from the models. A controversial hypothesis suggests that the dry and clear regions of the tropical atmosphere expand in a warming climate and thereby allow more infrared radiation to escape to space. This so-called iris effect could constitute a negative feedback that is not included in climate models. We find that inclusion of such an effect in a climate model moves the simulated responses of both temperature and the hydrological cycle to rising atmospheric greenhouse gas concentrations closer to observations. Alternative suggestions for shortcomings of models -- such as aerosol cooling, volcanic eruptions or insufficient ocean heat uptake -- may explain a slow observed transient warming relative to models, but not the observed enhancement of the hydrological cycle. We propose that, if precipitating convective clouds are more likely to cluster into larger clouds as temperatures rise, this process could constitute a plausible physical mechanism for an iris effect.

Overflows and Upper Ocean Interaction: A Mechanism for the Azores Current

DTIC Science & Technology

2006-09-01

at WHOI. They all saw my ups and downs and I enjoyed their presence in the office during the weekend and late at night. Taka Ito and Masa Sugiyama, my...Countercurrent forms near 380 N with a transport of 2 Sv. This location is 1 degree further north compared to the two-layer model (Figure 3-2) but... 380 N (see Section 1.4.3 for details). Although the origin and the transport of this current is still unclear, the study suggests the formation of

The clouds of Venus. [physical and chemical properties

NASA Technical Reports Server (NTRS)

Young, A. T.

1975-01-01

The physical and chemical properties of the clouds of Venus are reviewed, with special emphasis on data that are related to cloud dynamics. None of the currently-popular interpretations of cloud phenomena on Venus is consistent with all the data. Either a considerable fraction of the observational evidence is faulty or has been misinterpreted, or the clouds of Venus are much more complex than the current simplistic models. Several lines of attack are suggested to resolve some of the contradictions. A sound understanding of the clouds appears to be several years in the future.

Strain-induced shear instability in Liverpool Bay

NASA Astrophysics Data System (ADS)

Wihsgott, Juliane; Palmer, Matthew R.

2013-04-01

Liverpool Bay is a shallow subsection of the eastern Irish Sea with large tides (10 m), which drive strong tidal currents (1 ms-1). The Bay is heavily influenced by large freshwater inputs from several Welsh and English rivers that maintain a strong and persistent horizontal density gradient. This gradient interacts with the sheared tidal currents to strain freshwater over denser pelagic water on a semi-diurnal frequency. This Strain-Induced-Periodic-Stratification (SIPS) has important implications on vertical and horizontal mixing. The subtle interaction between stratification and turbulence in this complex environment is shown to be of critical importance to freshwater transport, and subsequently the fate of associated biogeochemical and pollutant pathways. Recent work identified an asymmetry of current ellipses due to SIPS that increases shear instability in the halocline with the potential to enhance diapycnal mixing. Here, we use data from a short, high intensity process study which reveals this mid-water mechanism maintains prolonged periods of sub-critical gradient Richardson number (Ri ≤ ¼) that suggests shear instability is likely. A time series of measurements from a microstructure profiler identifies the associated increase in turbulence is short lived and 'patchy' but sufficient to promote diapycnal mixing. The significance of this mixing process is further investigated by comparing our findings with long-term observations from the Liverpool Bay Coastal Observatory. We identify that the conditions for shear instability during SIPS are regularly met and suggest that this process contributes to the current underestimates of near coastal mixing observed in regional models. To assist our understanding of the observed processes and to test the current capability of turbulence 'closure schemes' we employ a one-dimensional numerical model to investigate the physical mechanisms driving diapycnal mixing in Liverpool Bay.

A causal framework for integrating contemporary and Vedic holism.

PubMed

Kineman, John J

2017-12-01

Whereas the last Century of science was characterized by epistemological uncertainty; the current Century will likely be characterized by ontological complexity (Gorban and Yablonsky, 2013). Advances in Systems Theory by mathematical biologist Robert Rosen suggest an elegant way forward (Rosen, 2013). "R-theory" (Kineman, 2012) is a synthesis of Rosen's theories explaining complexity and life in terms of a meta-model for 'whole' systems (and their fractions) in terms of "5 th -order holons". Such holons are Rosen "modeling relations" relating system-dependent processes with their formative contexts via closed cycles of four archetypal (Aristotelian) causes. This approach has post-predicted the three most basic taxa of life, plus a quasi-organismic form that may describe proto, component, and ecosystemic life. R-theory thus suggests a fundamentally complex ontology of existence inverting the current view that complexity arises from simple mechanisms. This model of cyclical causality corresponds to the ancient meta-model described in the Vedas and Upanishads of India. Part I of this discussion (Kineman, 2016a) presented a case for associating Vedic philosophy with Harappan civilization, allowing interpretation of ancient concepts of "cosmic order" (Rta) in the Rig Veda, nonduality (advaita), seven-fold beingness (saptanna) and other forms of holism appearing later in the Upanishads. By deciphering the model of wholeness that was applied and tested in ancient times, it is possible to compare, test, and confirm the holon model as a mathematical definition of life, systemic wholeness, and sustainability that may be applied today in modern terms, even as a foundation for holistic science. Copyright © 2017 Elsevier Ltd. All rights reserved.

Iranian kidney market in limbo: a commentary on "The ambiguous lessons of the Iranian model of paid living kidney donation".

PubMed

Soofi, Hojjat

2016-06-01

Sigrid Fry-Revere's The Kidney Sellers: A Journey of Discovery in Iran, an allegedly first-hand examination of the Iranian paid kidney donation model, has been criticized by Koplin in an essay formerly published in the Monash Bioethics Review. Koplin especially challenges Fry-Revere's claim that financially compensating kidney vendors might facilitate altruistic kidney donation. The current situation in Iran, according to Koplin, suggests that the market model has undermined altruistic donation. On this point, this commentary tries to show that healthcare policymakers in Iran no longer see the Iranian paid kidney donation model as a sustainable and ethically justifiable status quo. Briefly touching on the criticisms that have been made even by some positive commentators of the Iranian model, this commentary aims to call attention to the fact that the current dynamic within healthcare policymaking in Iran seeks primarily to decrease its reliance on the organ market instead of revising and modifying it. This complicates the plausibility of any kind of extrapolation, replication or extracting empirical support from the Iranian model to create organ markets in other countries, for example, as Fry-Revere suggests to conduct a trial of a financially incentivized kidney donation scheme in the US. The conclusion is that the Iranian healthcare system should tackle the organ shortage through increasing altruistic living and postmortem kidney donations. This might also provide, finally, a space for conducting extensive and long-term follow-up studies on well-being, satisfaction and social integration of Iranian kidney vendors.

A critical review of “Internet addiction” criteria with suggestions for the future

PubMed Central

VAN ROOIJ, ANTONIUS J.; PRAUSE, NICOLE

2014-01-01

Aims: In the last 5 years a deluge of articles on the topic of Internet addiction (IA) has proposed many candidate symptoms as evidence of this proposed disease. We critically reviewed the current approach to the measurement and identification of this new excessive behavior syndrome. Methods: Three popular models of IA were discussed: Griffith’s components model; Young’s Internet Addiction Test (IAT); and the criteria by Tao et al. (2010). We selected these models because they are widely cited and propose specific criteria for IA disorder. Our approach is not meant to provide an exhaustive review, but to discuss and critique the most salient trends in the field. Results: The models of Internet addiction share some criteria, including feeling a loss of control over Internet use; ensuing psychological, social, or professional conflict or problems; and preoccupation when not using the Internet. Other criteria inconsistently mentioned include: mood management, tolerance, withdrawal, and craving/anticipation. The models studied here share the assumption that the Internet can produce a qualitative shift to a diseased state in humans. Conclusions: We critically discussed the above criteria and concluded that the evidence base is currently not strong enough to provide support for an Internet addiction disorder. Future research areas are suggested: (1) Focusing on common impaired dimensions, (2) exploring neuroimaging as a model building tool, and (3) identifying shifts in the rewarding aspects of Internet use. Given the lack of consensus on the subject of Internet addiction, a focus on problem behaviors appears warranted. PMID:25592305

Dimensional Model for Estimating Factors influencing Childhood Obesity: Path Analysis Based Modeling

PubMed Central

Kheirollahpour, Maryam; Shohaimi, Shamarina

2014-01-01

The main objective of this study is to identify and develop a comprehensive model which estimates and evaluates the overall relations among the factors that lead to weight gain in children by using structural equation modeling. The proposed models in this study explore the connection among the socioeconomic status of the family, parental feeding practice, and physical activity. Six structural models were tested to identify the direct and indirect relationship between the socioeconomic status and parental feeding practice general level of physical activity, and weight status of children. Finally, a comprehensive model was devised to show how these factors relate to each other as well as to the body mass index (BMI) of the children simultaneously. Concerning the methodology of the current study, confirmatory factor analysis (CFA) was applied to reveal the hidden (secondary) effect of socioeconomic factors on feeding practice and ultimately on the weight status of the children and also to determine the degree of model fit. The comprehensive structural model tested in this study suggested that there are significant direct and indirect relationships among variables of interest. Moreover, the results suggest that parental feeding practice and physical activity are mediators in the structural model. PMID:25097878

Composite Stress Rupture: A New Reliability Model Based on Strength Decay

NASA Technical Reports Server (NTRS)

Reeder, James R.

2012-01-01

A model is proposed to estimate reliability for stress rupture of composite overwrap pressure vessels (COPVs) and similar composite structures. This new reliability model is generated by assuming a strength degradation (or decay) over time. The model suggests that most of the strength decay occurs late in life. The strength decay model will be shown to predict a response similar to that predicted by a traditional reliability model for stress rupture based on tests at a single stress level. In addition, the model predicts that even though there is strength decay due to proof loading, a significant overall increase in reliability is gained by eliminating any weak vessels, which would fail early. The model predicts that there should be significant periods of safe life following proof loading, because time is required for the strength to decay from the proof stress level to the subsequent loading level. Suggestions for testing the strength decay reliability model have been made. If the strength decay reliability model predictions are shown through testing to be accurate, COPVs may be designed to carry a higher level of stress than is currently allowed, which will enable the production of lighter structures

Dynamics of the seasonal variation of the North Equatorial Current bifurcation

NASA Astrophysics Data System (ADS)

Chen, Zhaohui; Wu, Lixin

2011-02-01

The dynamics of the seasonal variation of the North Equatorial Current (NEC) bifurcation is studied using a 1.5-layer nonlinear reduced-gravity Pacific basin model and a linear, first-mode baroclinic Rossby wave model. The model-simulated bifurcation latitude exhibits a distinct seasonal cycle with the southernmost latitude in June and the northernmost latitude in November, consistent with observational analysis. It is found that the seasonal migration of the NEC bifurcation latitude (NBL) not only is determined by wind locally in the tropics, as suggested in previous studies, but is also significantly intensified by the extratropical wind through coastal Kelvin waves. The model further demonstrates that the amplitude of the NEC bifurcation is also associated with stratification. A strong (weak) stratification leads to a fast (slow) phase speed of first-mode baroclinic Rossby waves, and thus large (small) annual range of the bifurcation latitude. Therefore, it is expected that in a warm climate the NBL should have a large range of annual migration.

The effects of ion channel blockers validate the conductance-based model of saccadic oscillations

PubMed Central

Shaikh, Aasef G.; Zee, David S.; Optican, Lance M.; Miura, Kenichiro; Ramat, Stefano; Leigh, R. John

2012-01-01

Conductance-based models of reciprocally inhibiting burst neurons suggest that intrinsic membrane properties and postinhibitory rebound (PIR) determine the amplitude and frequency of saccadic oscillations. Reduction of the low-threshold calcium currents (IT) in the model decreased the amplitude but increased the frequency of the simulated oscillations. Combined reduction of hyperpolarization-activated cation current (Ih) and IT in the model abolished the simulated oscillations. We measured the effects of a selective blocker of IT (ethosuximide) in healthy subjects on the amplitude and frequency of saccadic oscillations evoked by eye closure and of a nonselective blocker of Ih and IT (propronolol) in a patient with microsaccadic oscillation and limb tremor syndrome (mSOLT). Ethosuximide significantly reduced the amplitude but increased the frequency of the saccadic oscillations during eye closure in healthy subjects. Propranolol abolished saccadic oscillations in the mSOLT patient. These results support the hypothetical role of postinhibitory rebound, Ih, and IT, in generation of saccadic oscillations and determining their kinematic properties. PMID:21950976

Large eddy simulation of dust-uplift by haboob density currents

NASA Astrophysics Data System (ADS)

Huang, Q.

2017-12-01

Cold pool outflows have been shown from both observations and convection-permitting models to be a dominant source of dust uplift ("haboobs") in the summertime Sahel and Sahara, and to cause dust uplift over deserts across the world. In this paper large eddy model (LEM) simulations, which resolve the turbulence within the cold-pools much better than previous studies of haboobs which have used convection-permitting models, are used to investigate the winds that cause dust uplift in cold pools, and the resultant dust uplift and transport. Dust uplift largely occurs in the head of the density current, consistent with the few existing observations. In the modeled density current dust is largely restricted to the lowest coldest and well mixed layer of the cold pool outflow (below around 400 m), except above the head of the cold pool where some dust reaches 2.5 km. This rapid transport to high altitude will contribute to long atmospheric lifetimes of large dust particles from haboobs. Decreasing the model horizontal grid-spacing from 1.0 km to 100 m resolves more turbulence, locally increasing winds, increasing mixing and reducing the propagation speed of the density current. Total accumulated dust uplift is approximately twice as large in 1.0 km runs compared with 100 m runs, suggesting that for studying haboobs in convection-permitting runs the representation of turbulence and mixing is significant. Simulations with surface sensible heat fluxes representative of those from a desert region in daytime show that increasing surface fluxes slow the density current due to increased mixing, but increase dust uplift rates, due to increased downward transport of momentum to the surface.

Pathways From HIV-Related Stigma to Antiretroviral Therapy Measures in the HIV Care Cascade for Women Living With HIV in Canada.

PubMed

Logie, Carmen H; Lacombe-Duncan, Ashley; Wang, Ying; Kaida, Angela; Conway, Tracey; Webster, Kath; de Pokomandy, Alexandra; Loutfy, Mona R; Anema, Aranka; Becker, Denise; Brotto, Lori; Carter, Allison; Cardinal, Claudette; Colley, Guillaume; Ding, Erin; Duddy, Janice; Gataric, Nada; Hogg, Robert S; Hosward, Terry; Jabbari, Shahab; Jones, Evin; Kestler, Mary; Langlois, Andrea; Lima, Viviane; Lloyd-Smith, Elisa; Medjuck, Melissa; Miller, Cari; Money, Deborah; Nicholson, Valerie; Ogilvie, Gina; Patterson, Sophie; Pick, Neora; Roth, Eric; Salters, Kate; Sanchez, Margarite; Sas, Jacquie; Sereda, Paul; Summers, Marcie; Tom, Christina; Wang, Lu; Webster, Kath; Zhang, Wendy; Abdul-Noor, Rahma; Angel, Jonathan; Barry, Fatimatou; Bauer, Greta; Beaver, Kerrigan; Benoit, Anita; Bertozzi, Breklyn; Borton, Sheila; Bourque, Tammy; Brophy, Jason; Burchell, Ann; Carlson, Allison; Cioppa, Lynne; Cohen, Jeffrey; Conway, Tracey; Cooper, Curtis; Cotnam, Jasmine; Cousineau, Janette; Fraleigh, Annette; Gagnier, Brenda; Gasingirwa, Claudine; Greene, Saara; Hart, Trevor; Islam, Shazia; Kaushic, Charu; Kennedy, Logan; Kerr, Desiree; Kiboyogo, Maxime; Kwaramba, Gladys; Leonard, Lynne; Lewis, Johanna; Logie, Carmen; Margolese, Shari; Muchenje, Marvelous; Ndungʼu, Mary; OʼBrien, Kelly; Ouellette, Charlene; Powis, Jeff; Quan, Corinna; Raboud, Janet; Rachlis, Anita; Ralph, Edward; Rourke, Sean; Rueda, Sergio; Sandre, Roger; Smaill, Fiona; Smith, Stephanie; Tigere, Tsitsi; Tharao, Wangari; Walmsley, Sharon; Wobeser, Wendy; Yee, Jessica; Yudin, Mark; Baril, Jean-Guy; Burke, Nora Butler; Clément, Pierrette; Dayle, Janice; Dubuc, Danièle; Fernet, Mylène; Groleau, Danielle; Hot, Aurélie; Klein, Marina; Martin, Carrie; Massie, Lyne; Ménard, Brigitte; OʼBrien, Nadia; Otis, Joanne; Peltier, Doris; Pierre, Alie; Proulx-Boucher, Karène; Rouleau, Danielle; Savoie, Édénia; Tremblay, Cécile; Trottier, Benoit; Trottier, Sylvie; Tsoukas, Christos; Gahagan, Jacqueline; Hankins, Catherine; Masching, Renee; Ogunnaike-Cooke, Susanna

2018-02-01

Associations between HIV-related stigma and reduced antiretroviral therapy (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada. We used baseline survey data from a national cohort of women living with HIV in Canada (n = 1425). Structural equation modeling using weighted least squares estimation methods was conducted to test the direct effects of HIV-related stigma dimensions (personalized, negative self-image, and public attitudes) on ART initiation, current ART use, and 90% ART adherence, and indirect effects through depression and HIV disclosure concerns, adjusting for sociodemographic factors. In the final model, the direct paths from personalized stigma to ART initiation (β = -0.104, P < 0.05) and current ART use (β = -0.142, P < 0.01), and negative self-image to ART initiation (β = -0.113, P < 0.01) were significant, accounting for the mediation effects of depression and HIV disclosure concerns. Depression mediated the pathways from personalized stigma to ART adherence, and negative self-image to current ART use and ART adherence. Final model fit indices suggest that the model fit the data well [χ(25) = 90.251, P < 0.001; comparative fit index = 0.945; root-mean-square error of approximation = 0.044]. HIV-related stigma is associated with reduced likelihood of ART initiation and current ART use, and suboptimal ART adherence. To optimize the benefit of ART among women living with HIV, interventions should reduce HIV-related stigma and address depression.

GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia

PubMed Central

Gonzalez-Burgos, Guillermo; Fish, Kenneth N.; Lewis, David A.

2011-01-01

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning. Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission. A major role of GABA-mediated transmission may be producing synchronized network oscillations which are currently hypothesized to be essential for normal cognitive function. Therefore, cognitive deficits in schizophrenia may result from a GABA synapse dysfunction that disturbs neural synchrony. Here, we highlight recent studies further suggesting alterations of GABA transmission and network oscillations in schizophrenia. We also review current models for the mechanisms of GABA-mediated synchronization of neural activity, focusing on parvalbumin-positive GABA neurons, which are altered in schizophrenia and whose function has been strongly linked to the production of neural synchrony. Alterations of GABA signaling that impair gamma oscillations and, as a result, cognitive function suggest paths for novel therapeutic interventions. PMID:21904685

Modelling of illuminated current–voltage characteristics to evaluate leakage currents in long wavelength infrared mercury cadmium telluride photovoltaic detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gopal, Vishnu, E-mail: vishnu-46@yahoo.com, E-mail: wdhu@mail.sitp.ac.cn; Qiu, WeiCheng; Hu, Weida, E-mail: vishnu-46@yahoo.com, E-mail: wdhu@mail.sitp.ac.cn

2014-11-14

The current–voltage characteristics of long wavelength mercury cadmium telluride infrared detectors have been studied using a recently suggested method for modelling of illuminated photovoltaic detectors. Diodes fabricated on in-house grown arsenic and vacancy doped epitaxial layers were evaluated for their leakage currents. The thermal diffusion, generation–recombination (g-r), and ohmic currents were found as principal components of diode current besides a component of photocurrent due to illumination. In addition, both types of diodes exhibited an excess current component whose growth with the applied bias voltage did not match the expected growth of trap-assisted-tunnelling current. Instead, it was found to be themore » best described by an exponential function of the type, I{sub excess} = I{sub r0} + K{sub 1} exp (K{sub 2} V), where I{sub r0}, K{sub 1}, and K{sub 2} are fitting parameters and V is the applied bias voltage. A study of the temperature dependence of the diode current components and the excess current provided the useful clues about the source of origin of excess current. It was found that the excess current in diodes fabricated on arsenic doped epitaxial layers has its origin in the source of ohmic shunt currents. Whereas, the source of excess current in diodes fabricated on vacancy doped epitaxial layers appeared to be the avalanche multiplication of photocurrent. The difference in the behaviour of two types of diodes has been attributed to the difference in the quality of epitaxial layers.« less

A generalised model of secondary circulation for a wide range of geophysical flows from direct observations of natural turbidity currents

NASA Astrophysics Data System (ADS)

Azpiroz, M.; Cartigny, M.; Sumner, E. J.; Talling, P.; Parsons, D. R.; Clare, M. A.; Cooper, C.

2017-12-01

Turbidity currents transport sediment through submarine channel systems for hundreds of kilometres to form vast deposits of sediment in the deep sea called submarine fans. The largest submarine fans are fed by meandering channels suggesting that bends may enhance sediment transport distances. The interaction between meander bends and turbidity currents has been a topic of intense debate. Due to the absence of observations of deep-sea turbidity currents flowing through meander bends, our understanding has been based on experimental and numerical models. Measurements of geophysical flows demonstrate a common helical flow structure around meanders. Previous work has demonstrated that helical circulation in rivers is dominated by a single helix that rotates towards the inner bend at near-bed depths. In contrast, initial numerical and experimental models for turbidity currents found both river-like and river-reversed circulations. Saline flows in well-mixed estuaries show a river-like basal helical circulation, while stratified estuaries and saline flows are river-reversed. The existence of lateral stratification in stratified flows is thought to be the key factor in the change of direction of rotation. Stratification causes lateral pressure gradients that can govern the rotation of the flow helix. Turbidity currents are stratified due to their upwards-decreasing sediment load. It has therefore been proposed that stratified turbidity currents behave like stratified saline flow, but this hypothesis remains so far untested. Here we present the first observations of the helical flow in turbidity currents, which occurred within the deep-sea Congo Canyon. The measurements show a consistent river-reversed pattern downstream of the bend apex. Those results lead us to develop a new generalised model for a wide range of flows around meanders. Our conclusions have implications for understanding the flow erosional and depositional patterns, the evolution of channel systems and the architecture of the depositional record.

Attentional load and attentional boost: a review of data and theory.

PubMed

Swallow, Khena M; Jiang, Yuhong V

2013-01-01

Both perceptual and cognitive processes are limited in capacity. As a result, attention is selective, prioritizing items and tasks that are important for adaptive behavior. However, a number of recent behavioral and neuroimaging studies suggest that, at least under some circumstances, increasing attention to one task can enhance performance in a second task (e.g., the attentional boost effect). Here we review these findings and suggest a new theoretical framework, the dual-task interaction model, that integrates these findings with current views of attentional selection. To reconcile the attentional boost effect with the effects of attentional load, we suggest that temporal selection results in a temporally specific enhancement across modalities, tasks, and spatial locations. Moreover, the effects of temporal selection may be best observed when the attentional system is optimally tuned to the temporal dynamics of incoming stimuli. Several avenues of research motivated by the dual-task interaction model are then discussed.

Attentional Load and Attentional Boost: A Review of Data and Theory

PubMed Central

Swallow, Khena M.; Jiang, Yuhong V.

2013-01-01

Both perceptual and cognitive processes are limited in capacity. As a result, attention is selective, prioritizing items and tasks that are important for adaptive behavior. However, a number of recent behavioral and neuroimaging studies suggest that, at least under some circumstances, increasing attention to one task can enhance performance in a second task (e.g., the attentional boost effect). Here we review these findings and suggest a new theoretical framework, the dual-task interaction model, that integrates these findings with current views of attentional selection. To reconcile the attentional boost effect with the effects of attentional load, we suggest that temporal selection results in a temporally specific enhancement across modalities, tasks, and spatial locations. Moreover, the effects of temporal selection may be best observed when the attentional system is optimally tuned to the temporal dynamics of incoming stimuli. Several avenues of research motivated by the dual-task interaction model are then discussed. PMID:23730294

Transient tidal eddy motion in the western Gulf of Maine, part 1: Primary structure

NASA Astrophysics Data System (ADS)

Brown, W. S.; Marques, G. M.

2013-07-01

High frequency radar-derived surface current maps of the Great South Channel (GSC) in the western Gulf of Maine in 2005 revealed clockwise (CW) and anticlockwise (ACW) eddy motion associated with the strong regional tidal currents. To better elucidate the kinematics and dynamics of these transient tidal eddy motions, an observational and modeling study was conducted during the weakly stratified conditions of winter 2008-2009. Our moored bottom pressure and ADCP current measurements in 13m depth were augmented by historical current measurements in about 30m in documenting the dominance of highly polarized M2 semidiurnal currents in our nearshore study region. The high-resolution finite element coastal ocean model (QUODDY) - forced by the five principal tidal constituents - produced maps depicting the formation and evolution of the CW and ACW eddy motions that regularly follow maximum ebb and flood flows, respectively. Observation versus model current comparison required that the model bottom current drag coefficient be set to at an unusually high Cd=0.01 - suggesting the importance of form drag in the study region. The observations and model results were consistent in diagnosing CW or ACW eddy motions that (a) form nearshore in the coastal boundary layer (CBL) for about 3h after the respective tidal current maxima and then (b) translate southeastward across the GSC along curved 50m isobath at speeds of about 25m/s. Observation-based and model-based momentum budget estimates were consistent in showing a first order forced semidiurnal standing tidal wave dynamics (like the adjacent Gulf of Maine) which was modulated by adverse pressure gradient/bottom stress forcing to generate the eddy motions. Observation-based estimates of terms in the transport vorticity budget showed that in the shallower Inner Zone subregion (average depth=23m) that the diffusion of nearshore vorticity was dominant in feeding the growth of eddy motion vorticity; while in the somewhat deeper Outer Zone subregion (33m) bottom current lateral shear and water column stretching/squashing was significant in modulating the eddy motion. We conclude that the transient eddy motions in the GSC region are phase eddies that accompany the change of tide across the GSC and are (1) generated by bottom stress gradients in the shallower nearshore - an issue which needs to be better understood for improved future forecasting.

Self-monitoring in the cerebral cortex: Neural responses to small pitch shifts in auditory feedback during speech production.

PubMed

Franken, Matthias K; Eisner, Frank; Acheson, Daniel J; McQueen, James M; Hagoort, Peter; Schoffelen, Jan-Mathijs

2018-06-21

Speaking is a complex motor skill which requires near instantaneous integration of sensory and motor-related information. Current theory hypothesizes a complex interplay between motor and auditory processes during speech production, involving the online comparison of the speech output with an internally generated forward model. To examine the neural correlates of this intricate interplay between sensory and motor processes, the current study uses altered auditory feedback (AAF) in combination with magnetoencephalography (MEG). Participants vocalized the vowel/e/and heard auditory feedback that was temporarily pitch-shifted by only 25 cents, while neural activity was recorded with MEG. As a control condition, participants also heard the recordings of the same auditory feedback that they heard in the first half of the experiment, now without vocalizing. The participants were not aware of any perturbation of the auditory feedback. We found auditory cortical areas responded more strongly to the pitch shifts during vocalization. In addition, auditory feedback perturbation resulted in spectral power increases in the θ and lower β bands, predominantly in sensorimotor areas. These results are in line with current models of speech production, suggesting auditory cortical areas are involved in an active comparison between a forward model's prediction and the actual sensory input. Subsequently, these areas interact with motor areas to generate a motor response. Furthermore, the results suggest that θ and β power increases support auditory-motor interaction, motor error detection and/or sensory prediction processing. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Energy-Efficient and Environmentally Friendly Solid Oxide Membrane Electrolysis Process for Magnesium Oxide Reduction: Experiment and Modeling

NASA Astrophysics Data System (ADS)

Guan, Xiaofei; Pal, Uday B.; Powell, Adam C.

2014-06-01

This paper reports a solid oxide membrane (SOM) electrolysis experiment using an LSM(La0.8Sr0.2MnO3-δ)-Inconel inert anode current collector for production of magnesium and oxygen directly from magnesium oxide at 1423 K (1150 °C). The electrochemical performance of the SOM cell was evaluated by means of various electrochemical techniques including electrochemical impedance spectroscopy, potentiodynamic scan, and electrolysis. Electronic transference numbers of the flux were measured to assess the magnesium dissolution in the flux during SOM electrolysis. The effects of magnesium solubility in the flux on the current efficiency and the SOM stability during electrolysis are discussed. An inverse correlation between the electronic transference number of the flux and the current efficiency of the SOM electrolysis was observed. Based on the experimental results, a new equivalent circuit of the SOM electrolysis process is presented. A general electrochemical polarization model of SOM process for magnesium and oxygen gas production is developed, and the maximum allowable applied potential to avoid zirconia dissociation is calculated as well. The modeling results suggest that a high electronic resistance of the flux and a relatively low electronic resistance of SOM are required to achieve membrane stability, high current efficiency, and high production rates of magnesium and oxygen.

Modeling hydraulic and sediment transport processes in white sturgeon spawning habitat on the Kootenai River, Idaho

USGS Publications Warehouse

McDonald, Richard R.; Nelson, Jonathan M.; Vaughn Paragamian,; Barton, Gary J.

2017-01-01

The Kootenai River white sturgeon currently spawn (2005) in an 18-kilometer reach of the Kootenai River, Idaho. Since completion of Libby Dam upstream from the spawning reach, there has been only one successful year of recruitment of juvenile fish. Where successful in other rivers, white sturgeon spawn over clean coarse material of gravel size or larger. The channel substrate in the current spawning reach is composed primarily of sand and some buried gravel; within a few kilometers upstream there is clean gravel. We used a 2-dimensional flow and sediment-transport model and the measured locations of sturgeon spawning from 1994-2002 to gain insight into the paradox between the current spawning location and the absence of suitable substrate. Spatial correlations between spawning locations and the model simulations of velocity and depth indicate the white sturgeon tend to select regions of highest velocity and depth within any river cross-section to spawn. These regions of high velocity and depth are independent of pre- or post-dam flow conditions. A simple sediment-transport simulation suggests that high discharge and relatively long duration flow associated with pre-dam flow events might be sufficient to scour the sandy substrate and expose existing lenses of gravel and cobble as lag deposits in the current spawning reach.

Space plasma contactor research, 1987

NASA Technical Reports Server (NTRS)

Wilbur, Paul J.

1988-01-01

A simple model describing the process of electron collection from a low pressure ambient plasma in the absence of magnetic field and contactor velocity effects is presented. Experimental measurments of the plasma surrounding the contactor are used to demonstrate that a double-sheath generally develops and separates the ambient plasma from a higher density, anode plasma located adjacent to the contactor. Agreement between the predictions of the model and experimental measurements obtained at the electron collection current levels ranging to 1 A suggests the surface area at the ambient plasma boundary of the double-sheath is equal to the electron current being collected divided by the ambient plasma random electron current density; the surface area of the higher density anode plasma boundary of the double-sheath is equal to the ion current being emitted across this boundary divided by the ion current density required to sustain a stable sheath; and the voltage drop across the sheath is determined by the requirement that the ion and electron currents counterflowing across the boundaries be at space-charge limited levels. The efficiency of contactor operation is shown to improve when significant ionization and excitation is induced by electrons that stream from the ambient plasma through the double-sheath and collide with neutral atoms being supplied through the hollow cathode.

Quantitative, steady-state properties of Catania's computational model of the operant reserve.

PubMed

Berg, John P; McDowell, J J

2011-05-01

Catania (2005) found that a computational model of the operant reserve (Skinner, 1938) produced realistic behavior in initial, exploratory analyses. Although Catania's operant reserve computational model demonstrated potential to simulate varied behavioral phenomena, the model was not systematically tested. The current project replicated and extended the Catania model, clarified its capabilities through systematic testing, and determined the extent to which it produces behavior corresponding to matching theory. Significant departures from both classic and modern matching theory were found in behavior generated by the model across all conditions. The results suggest that a simple, dynamic operant model of the reflex reserve does not simulate realistic steady state behavior. Copyright © 2011 Elsevier B.V. All rights reserved.

Indirectly pumped 3.7 THz InGaAs/InAlAs quantum-cascade lasers grown by metal-organic vapor-phase epitaxy.

PubMed

Fujita, Kazuue; Yamanishi, Masamichi; Furuta, Shinichi; Tanaka, Kazunori; Edamura, Tadataka; Kubis, Tillmann; Klimeck, Gerhard

2012-08-27

Device-performances of 3.7 THz indirect-pumping quantum-cascade lasers are demonstrated in an InGaAs/InAlAs material system grown by metal-organic vapor-phase epitaxy. The lasers show a low threshold-current-density of ~420 A/cm2 and a peak output power of ~8 mW at 7 K, no sign of parasitic currents with recourse to well-designed coupled-well injectors in the indirect pump scheme, and a maximum operating temperature of Tmax ~100 K. The observed roll-over of output intensities in current ranges below maximum currents and limitation of Tmax are discussed with a model for electron-gas heating in injectors. Possible ways toward elevation of Tmax are suggested.

Investigating melting induced mantle heterogeneities in plate driven mantle convection models

NASA Astrophysics Data System (ADS)

Price, M.; Davies, H.; Panton, J.

2017-12-01

Observations from geochemistry and seismology continue to suggest a range of complex heterogeneity in Earth's mantle. In the deep mantle, two large low velocity provinces (LLVPs) have been regularly observed in seismic studies, with their longevity, composition and density compared to the surrounding mantle debated. The cause of these observed LLVPs is equally uncertain, with previous studies advocating either thermal or thermo-chemical causes. There is also evidence that these structures could provide chemically distinct reservoirs within the mantle, with recent studies also suggesting there may be additional reservoirs in the mantle, such as bridgmanite-enriched ancient mantle structures (BEAMS). One way to test these hypotheses is using computational models of the mantle, with models that capture the full 3D system being both complex and computationally expensive. Here we present results from our global mantle model TERRA. Using our model, we can track compositional variations in the convecting mantle that are generated by self-consistent, evolving melting zones. Alongside the melting, we track trace elements and other volatiles which can be partitioned during melting events, and expelled and recycled at the surface. Utilising plate reconstruction models as a boundary condition, the models generate the tectonic features observed at Earth's surface, while also organising the lower mantle into recognisable degree-two structures. This results in our models generating basaltic `oceanic' crusts which are then brought into the mantle at tectonic boundaries, providing additional chemical heterogeneity in the mantle volume. Finally, by utilising thermodynamic lookup tables to convert the final outputs from the model to seismic structures, together with resolution filters for global tomography models, we are able to make direct comparisons between our results and observations. By varying the parameters of the model, we investigate a range of current hypotheses for heterogeneity in the mantle. Our work attempts to reconcile the many proposed current ideas for the deep mantle, giving additional insight from modelling on the latest observations from other Deep Earth disciplines.

Expertly Validated Models and Phylogenetically-Controlled Analysis Suggests Responses to Climate Change Are Related to Species Traits in the Order Lagomorpha

PubMed Central

Leach, Katie; Kelly, Ruth; Cameron, Alison; Montgomery, W. Ian; Reid, Neil

2015-01-01

Climate change during the past five decades has impacted significantly on natural ecosystems, and the rate of current climate change is of great concern among conservation biologists. Species Distribution Models (SDMs) have been used widely to project changes in species’ bioclimatic envelopes under future climate scenarios. Here, we aimed to advance this technique by assessing future changes in the bioclimatic envelopes of an entire mammalian order, the Lagomorpha, using a novel framework for model validation based jointly on subjective expert evaluation and objective model evaluation statistics. SDMs were built using climatic, topographical, and habitat variables for all 87 lagomorph species under past and current climate scenarios. Expert evaluation and Kappa values were used to validate past and current models and only those deemed ‘modellable’ within our framework were projected under future climate scenarios (58 species). Phylogenetically-controlled regressions were used to test whether species traits correlated with predicted responses to climate change. Climate change is likely to impact more than two-thirds of lagomorph species, with leporids (rabbits, hares, and jackrabbits) likely to undertake poleward shifts with little overall change in range extent, whilst pikas are likely to show extreme shifts to higher altitudes associated with marked range declines, including the likely extinction of Kozlov’s Pika (Ochotona koslowi). Smaller-bodied species were more likely to exhibit range contractions and elevational increases, but showing little poleward movement, and fecund species were more likely to shift latitudinally and elevationally. Our results suggest that species traits may be important indicators of future climate change and we believe multi-species approaches, as demonstrated here, are likely to lead to more effective mitigation measures and conservation management. We strongly advocate studies minimising data gaps in our knowledge of the Order, specifically collecting more specimens for biodiversity archives and targeting data deficient geographic regions. PMID:25874407

The potential value of Clostridium difficile vaccine: an economic computer simulation model.

PubMed

Lee, Bruce Y; Popovich, Michael J; Tian, Ye; Bailey, Rachel R; Ufberg, Paul J; Wiringa, Ann E; Muder, Robert R

2010-07-19

Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease. (c) 2010 Elsevier Ltd. All rights reserved.