Louisiana Department of Transportation and Development in-house versus consultant design cost study : technical assistance report.

DOT National Transportation Integrated Search

1998-05-01

State transportation agencies commonly use consultant firms for some of their highway and bridge design. For example, the Louisiana Department of Transportation and Development (hereafter referred to as the "Department" or "LaDOTD") currently uses bo...

Ares V Overview and Status

NASA Technical Reports Server (NTRS)

Creech, Steve; Sumrall, Phil; Cockrell, Charles E., Jr.; Burris, Mike

2009-01-01

As part of NASA s Constellation Program to resume exploration beyond low Earth orbit (LEO), the Ares V heavy-lift cargo launch vehicle as currently conceived will be able to send more crew and cargo to more places on the Moon than the Apollo Program Saturn V. (Figure 1) It also has unprecedented cargo mass and volume capabilities that will be a national asset for science, commerce, and national defense applications. Compared to current systems, it will offer approximately five times the mass and volume to most orbits and locations. The Columbia space shuttle accident, the resulting investigation, the Vision for Space Exploration, and the Exploration Systems Architecture Study (ESAS) broadly shaped the Constellation architecture. Out of those events and initiatives emerged an architecture intended to replace the space shuttle, complete the International Space Station (ISS), resume a much more ambitious plan to explore the moon as a stepping stone to other destinations in the solar system. The Ares I was NASA s main priority because of the goal to retire the Shuttle. Ares V remains in a concept development phase, evolving through hundreds of configurations. The current reference design was approved during the Lunar Capabilities Concept Review/Ares V Mission Concept Review (LCCR/MCR) in June 2008. This reference concept serves as a starting point for a renewed set of design trades and detailed analysis into its interaction with the other components of the Constellation architecture and existing launch infrastructure. In 2009, the Ares V team was heavily involved in supporting the Review of U.S. Human Space Flight Plans Committee. Several alternative designs for Ares V have been supplied to the committee. This paper will discuss the origins of the Ares V design, the evolution to the current reference configuration, and the options provided to the review committee.

The LIFE Laser Design in Context: A Comparison to the State-of-the-Art

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deri, R J; Bayramian, A J; Erlandson, A C

2011-03-21

The current point design for the LIFE laser leverages decades of solid-state laser development in order to achieve the performance and attributes required for inertial fusion energy. This document provides a brief comparison of the LIFE laser point design to other state-of-the-art solid-state lasers. Table I compares the attributes of the current LIFE laser point design to other systems. the state-of-the-art for single-shot performance at fusion-relevant beamline energies is exemplified by performance observed on the National Ignition Facility. The state-of-the-art for high average power is exemplified by the Northrup Grumman JHPSSL laser. Several items in Table I deal with themore » laser efficiency; a more detailed discussion of efficiency can be found in reference 5. The electrical-to-optical efficiency of the LIFE design exceeds that of reference 4 due to the availability of higher efficiency laser diode pumps (70% vs. {approx}50% used in reference 4). LIFE diode pumps are discussed in greater detail in reference 6. The 'beam steering' state of the art is represented by the deflection device that will be used in the LIFE laser, not a laser system. Inspection of Table I shows that most LIFE laser attributes have already been experimentally demonstrated. The two cases where the LIFE design is somewhat better than prior experimental work do not involve the development of new concepts: beamline power is increased simply by increasing aperture (as demonstrated by the power/aperture comparison in Table I), and efficiency increases are achieved by employing state-of-the-art diode pumps. In conclusion, the attributes anticipated for the LIFE laser are consistent with the demonstrated performance of existing solid-state lasers.« less

Multiparameter optimization of mammography: an update

NASA Astrophysics Data System (ADS)

Jafroudi, Hamid; Muntz, E. P.; Jennings, Robert J.

1994-05-01

Previously in this forum we have reported the application of multiparameter optimization techniques to the design of a minimum dose mammography system. The approach used a reference system to define the physical imaging performance required and the dose to which the dose for the optimized system should be compared. During the course of implementing the resulting design in hardware suitable for laboratory testing, the state of the art in mammographic imaging changed, so that the original reference system, which did not have a grid, was no longer appropriate. A reference system with a grid was selected in response to this change, and at the same time the optimization procedure was modified, to make it more general and to facilitate study of the optimized design under a variety of conditions. We report the changes in the procedure, and the results obtained using the revised procedure and the up- to-date reference system. Our results, which are supported by laboratory measurements, indicate that the optimized design can image small objects as well as the reference system using only about 30% of the dose required by the reference system. Hardware meeting the specification produced by the optimization procedure and suitable for clinical use is currently under evaluation in the Diagnostic Radiology Department at the Clinical Center, NH.

Progress in cybernetics and systems research. Vol. XI. Data base design. International Information Systems. Semiotic Systems. Artificial Intelligence. Cybernetics and Philosophy. Special aspects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trappl, R.; Findler, N.V.; Horn, W.

1982-01-01

This book covers current research topics in six areas. These are data base design, international information systems, semiotic systems, artificial intelligence, cybernetics and philosophy, and special aspects of systems research. 1326 references.

A Calibrated Power Prior Approach to Borrow Information from Historical Data with Application to Biosimilar Clinical Trials.

PubMed

Pan, Haitao; Yuan, Ying; Xia, Jielai

2017-11-01

A biosimilar refers to a follow-on biologic intended to be approved for marketing based on biosimilarity to an existing patented biological product (i.e., the reference product). To develop a biosimilar product, it is essential to demonstrate biosimilarity between the follow-on biologic and the reference product, typically through two-arm randomization trials. We propose a Bayesian adaptive design for trials to evaluate biosimilar products. To take advantage of the abundant historical data on the efficacy of the reference product that is typically available at the time a biosimilar product is developed, we propose the calibrated power prior, which allows our design to adaptively borrow information from the historical data according to the congruence between the historical data and the new data collected from the current trial. We propose a new measure, the Bayesian biosimilarity index, to measure the similarity between the biosimilar and the reference product. During the trial, we evaluate the Bayesian biosimilarity index in a group sequential fashion based on the accumulating interim data, and stop the trial early once there is enough information to conclude or reject the similarity. Extensive simulation studies show that the proposed design has higher power than traditional designs. We applied the proposed design to a biosimilar trial for treating rheumatoid arthritis.

Low-power G m-C filter employing current-reuse differential difference amplifiers

DOE PAGES

Mincey, John S.; Briseno-Vidrios, Carlos; Silva-Martinez, Jose; ...

2016-08-10

This study deals with the design of low-power, high performance, continuous-time filters. The proposed OTA architecture employs current-reuse differential difference amplifiers in order to produce more power efficient Gm-C filter solutions. To demonstrate this, a 6th order low-pass Butterworth filter was designed in 0.18 m CMOS achieving a 65-MHz -3-dB frequency, an in-band input-referred third-order intercept point of 12.0 dBm, and an input referred noise density of 40 nV/Hz1=2, while only consuming 8.07 mW from a 1.8 V supply and occupying a total chip area of 0.21 mm2 with a power consumption of only 1.19 mW per pole.

Low-power G m-C filter employing current-reuse differential difference amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mincey, John S.; Briseno-Vidrios, Carlos; Silva-Martinez, Jose

This study deals with the design of low-power, high performance, continuous-time filters. The proposed OTA architecture employs current-reuse differential difference amplifiers in order to produce more power efficient Gm-C filter solutions. To demonstrate this, a 6th order low-pass Butterworth filter was designed in 0.18 m CMOS achieving a 65-MHz -3-dB frequency, an in-band input-referred third-order intercept point of 12.0 dBm, and an input referred noise density of 40 nV/Hz1=2, while only consuming 8.07 mW from a 1.8 V supply and occupying a total chip area of 0.21 mm2 with a power consumption of only 1.19 mW per pole.

Quantitative imaging biomarkers: a review of statistical methods for computer algorithm comparisons.

PubMed

Obuchowski, Nancy A; Reeves, Anthony P; Huang, Erich P; Wang, Xiao-Feng; Buckler, Andrew J; Kim, Hyun J Grace; Barnhart, Huiman X; Jackson, Edward F; Giger, Maryellen L; Pennello, Gene; Toledano, Alicia Y; Kalpathy-Cramer, Jayashree; Apanasovich, Tatiyana V; Kinahan, Paul E; Myers, Kyle J; Goldgof, Dmitry B; Barboriak, Daniel P; Gillies, Robert J; Schwartz, Lawrence H; Sullivan, Daniel C

2015-02-01

Quantitative biomarkers from medical images are becoming important tools for clinical diagnosis, staging, monitoring, treatment planning, and development of new therapies. While there is a rich history of the development of quantitative imaging biomarker (QIB) techniques, little attention has been paid to the validation and comparison of the computer algorithms that implement the QIB measurements. In this paper we provide a framework for QIB algorithm comparisons. We first review and compare various study designs, including designs with the true value (e.g. phantoms, digital reference images, and zero-change studies), designs with a reference standard (e.g. studies testing equivalence with a reference standard), and designs without a reference standard (e.g. agreement studies and studies of algorithm precision). The statistical methods for comparing QIB algorithms are then presented for various study types using both aggregate and disaggregate approaches. We propose a series of steps for establishing the performance of a QIB algorithm, identify limitations in the current statistical literature, and suggest future directions for research. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

USAF Damage Tolerant Design Handbook: Guidelines for the Analysis and Design of Damage Tolerant Aircraft Structures. Revision B

DTIC Science & Technology

1984-05-01

Effect of Block Programming and Block Size on Crack Growth Life (All Histories Have Same Cycle Content) Alloy : 2024 -T3 Aluminum (Reference 27...1 I 6 o T 1 >0 100 Crack Growth Life for l-in. Crack Growth 1000 Figure 5.1.10, Effect of Humidity on Fatigue Crack Propagation...Growth Life (All Histories Have Same Cycle Content) Alloy : 2024 -T3 Aluminum (Reference 27). 5.2.6 Yield Zone Due to Overload (r T), Current Crack

Habitability in Advanced Space Mission Design. Part 2; Evaluation of Habitation Elements

NASA Technical Reports Server (NTRS)

Adams, Constance M.; McCurdy, Matthew R.

2000-01-01

Habitability is a fundamental component of any long-duration human habitat. Due to the pressures on the crew and the criticality of their performance, this is particularly true of habitats or vehicles proposed for use in any human space mission of duration over 30 days. This paper, the second of three on this subject, will focus on evaluating all the vehicles currently under consideration for the Mars Design Reference Mission through application of metrics for habitability (proposed in a previous paper, see references Adams/McCurdy 1999).

Solar Energy: Solar System Design Fundamentals.

ERIC Educational Resources Information Center

Knapp, Henry H., III

This module on solar system design fundamentals is one of six in a series intended for use as supplements to currently available materials on solar energy and energy conservation. Together with the recommended texts and references (sources are identified), these modules provide an effective introduction to energy conservation and solar energy…

Developing the Next Generation NATO Reference Mobility Model

DTIC Science & Technology

2016-06-27

acquisition • design UNCLASSIFIED: Distribution Statement A. Approved for public release; distribution is unlimited.(#27992) Vehicle Dynamics Model...and numerical resolution – for use in vehicle design , acquisition and operational mobility planning 27 June 2016 An open architecture was established...the current empirical methods for simulating vehicle and suspension designs . – Industry wide shortfall with tire dynamics and soft soil behavior

Monitoring of Waves and Currents Near the Alabama Dredged Materials Mounds

DTIC Science & Technology

1994-09-01

34 Coniclusions. .. .. .. .. .. .... .... .... .... .. .... ........ 35 V References...System Design 17 Alm zSm ! , ,- Mi’ 2< 7 _ _ Ii~ ... . . .. I 18 Chapter 5 System Doaign repeated impacts by trawlers. A brief description of the...less than 4 dcg. Chaptor 6 Fioeuits 35 rii ReferencesII Bradley, K. P., and Hands, E. B. (1989). "Dredged material underwater berms." Proceedings of

REVIEW OF POWER AND HEAT REACTOR DESIGNS. Domestic and Foreign

DOE Office of Scientific and Technical Information (OSTI.GOV)

Appleby, E.R., comp

1963-10-01

Unclassified information from domestic and foreign literature from January 1952 through September 1963 is compiled. Design characteristics and current information on the status of the individual designs are given, along with references for the associated literature. SNAP systems, proposed reactors, and chemonuclear and test reactors with characteristics similar to power reactors are included. The designs are indexed by name, location, type, and some special characteristics. (D.C.W.)

Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient.

PubMed

Datta, Abhishek; Baker, Julie M; Bikson, Marom; Fridriksson, Julius

2011-07-01

Although numerous published reports have demonstrated the beneficial effects of transcranial direct-current stimulation (tDCS) on task performance, fundamental questions remain regarding the optimal electrode configuration on the scalp. Moreover, it is expected that lesioned brain tissue will influence current flow and should therefore be considered (and perhaps leveraged) in the design of individualized tDCS therapies for stroke. The current report demonstrates how different electrode configurations influence the flow of electrical current through brain tissue in a patient who responded positively to a tDCS treatment targeting aphasia. The patient, a 60-year-old man, sustained a left hemisphere ischemic stroke (lesion size = 87.42 mL) 64 months before his participation. In this study, we present results from the first high-resolution (1 mm(3)) model of tDCS in a brain with considerable stroke-related damage; the model was individualized for the patient who received anodal tDCS to his left frontal cortex with the reference cathode electrode placed on his right shoulder. We modeled the resulting brain current flow and also considered three additional reference electrode positions: right mastoid, right orbitofrontal cortex, and a "mirror" configuration with the anode over the undamaged right cortex. Our results demonstrate the profound effect of lesioned tissue on resulting current flow and the ability to modulate current pattern through the brain, including perilesional regions, through electrode montage design. The complexity of brain current flow modulation by detailed normal and pathologic anatomy suggest: (1) That computational models are critical for the rational interpretation and design of individualized tDCS stroke-therapy; and (2) These models must accurately reproduce head anatomy as shown here. Copyright © 2011 Elsevier Inc. All rights reserved.

Function, form, and technology - The evolution of Space Station in NASA

NASA Technical Reports Server (NTRS)

Fries, S. D.

1985-01-01

The history of major Space Station designs over the last twenty-five years is reviewed. The evolution of design concepts is analyzed with respect to the changing functions of Space Stations; and available or anticipated technology capabilities. Emphasis is given to the current NASA Space Station reference configuration, the 'power tower'. Detailed schematic drawings of the different Space Station designs are provided.

An inherent curvature-compensated voltage reference using non-linearity of gate coupling coefficient

NASA Astrophysics Data System (ADS)

Hande, Vinayak; Shojaei Baghini, Maryam

2015-08-01

A novel current-mode voltage reference circuit which is capable of generating sub-1 V output voltage is presented. The proposed architecture exhibits the inherent curvature compensation ability. The curvature compensation is achieved by utilizing the non-linear behavior of gate coupling coefficient to compensate non-linear temperature dependence of base-emitter voltage. We have also utilized the developments in CMOS process to reduce power and area consumption. The proposed voltage reference is analyzed theoretically and compared with other existing methods. The circuit is designed and simulated in 180 nm mixed-mode CMOS UMC technology which gives a reference level of 246 mV. The minimum required supply voltage is 1 V with maximum current drawn of 9.24 μA. A temperature coefficient of 9 ppm/°C is achieved over -25 to 125 °C temperature range. The reference voltage varies by ±11 mV across process corners. The reference circuit shows the line sensitivity of 0.9 mV/V with area consumption of 100 × 110 μm2

Loads and low frequency dynamics - An ENVIRONET data base

NASA Technical Reports Server (NTRS)

Garba, John A.

1988-01-01

The loads and low frequency dynamics data base, part of Environet, is described with particular attention given to its development and contents. The objective of the data base is to provide the payload designer with design approaches and design data to meet STS safety requirements. Currently the data base consists of the following sections: abstract, scope, glossary, requirements, interaction with other environments, summary of the loads analysis process, design considerations, guidelines for payload design loads, information data base, and references.

Recent experience with design and manufacture of cine lenses

NASA Astrophysics Data System (ADS)

Thorpe, Michael D.; Dalzell, Kristen E.

2015-09-01

Modern cine lenses require a high degree of aberration correction over a large and ever expanding image size. At low to medium volume production levels, these highly corrected designs also require a workable tolerance set and compensation scheme for successful manufacture. In this paper we discuss the design and manufacture of cine lenses with reference to current designs both internal and in the patent literature and some experience in design, tolerancing and manufacturing these lenses in medium volume production.

STANDARD REFERENCE MATERIALS FOR THE POLYMERS INDUSTRY.

PubMed

McDonough, Walter G; Orski, Sara V; Guttman, Charles M; Migler, Kalman D; Beers, Kathryn L

2016-01-01

The National Institute of Standards and Technology (NIST) provides science, industry, and government with a central source of well-characterized materials certified for chemical composition or for some chemical or physical property. These materials are designated Standard Reference Materials ® (SRMs) and are used to calibrate measuring instruments, to evaluate methods and systems, or to produce scientific data that can be referred readily to a common base. In this paper, we discuss the history of polymer based SRMs, their current status, and challenges and opportunities to develop new standards to address industrial measurement challenges.

Enhanced thermo-spin effects in iron-oxide/metal multilayers

NASA Astrophysics Data System (ADS)

Ramos, R.; Lucas, I.; Algarabel, P. A.; Morellón, L.; Uchida, K.; Saitoh, E.; Ibarra, M. R.

2018-06-01

Since the discovery of the spin Seebeck effect (SSE), much attention has been devoted to the study of the interaction between heat, spin, and charge in magnetic systems. The SSE refers to the generation of a spin current upon the application of a thermal gradient and detected by means of the inverse spin Hall effect. Conversely, the spin Peltier effect (SPE) refers to the generation of a heat current as a result of a spin current induced by the spin Hall effect. Here we report a strong enhancement of both the SSE and SPE in Fe3O4/Pt multilayered thin films at room temperature as a result of an increased thermo-spin conversion efficiency in the multilayers. These results open the possibility to design thin film heterostructures that may boost the application of thermal spin currents in spintronics.

Operating guidelines for TxDOT ramp control signals.

DOT National Transportation Integrated Search

2009-01-01

The Texas Department of Transportation (TxDOT) currently maintains a Traffic Signals Manual. : Originally published in 1999, this manual provides a guide and reference for handling requests : for traffic signals on the designated State Highway System...

Design of the Core Stage Inter-Tank Umbilical {CSITU) Compliance Mechanism

NASA Technical Reports Server (NTRS)

Smith, Kurt R.

2013-01-01

Project Goals: a) Design the compliance mechanism for the CSITU system to a 30% level -3D models completed in Pro/Engineer -Relevant design analysis b) Must meet all system requirements and establish basis for proceeding with detailed design. Tasks to be completed: A design that meets requirements for the 30% design review, 01/16/2013. Umbilical arms provide commodities to the launch vehicle prior to T-0. Commodities can range anywhere from hydraulics, pneumatics, cryogenic, electrical, ECS, etc ... Umbilicals commonly employ truss structures to deliver commodities to vehicle. Common configurations include: -Tilt-up -Swing Arm -Hose Drape -Drop Arm Umbilical arms will be mounted to Mobile Launch Platform. SLS currently has 9 T-0 umbilical arms. The compliance refers to the ability of the umbilical to adjust to minor changes in vehicle location. The compliance mechanism refers to the mechanism on the ground support equipment {GSE) that compensates for these changes. For the CSITU, these minor changes, or vehicle excursions, can be up to +4 in. Excursions refer to movements of the vehicle caused by wind loads and thermal expansion. It is ideal to have significant vertical compliance so a passive secondary release mechanism may be implemented.

[International bibliographic databases--Current Contents on disk and in FTP format (Internet): presentation and guide].

PubMed

Bloch-Mouillet, E

1999-01-01

This paper aims to provide technical and practical advice about finding references using Current Contents on disk (Macintosh or PC) or via the Internet (FTP). Seven editions are published each week. They are all organized in the same way and have the same search engine. The Life Sciences edition, extensively used in medical research, is presented here in detail, as an example. This methodological note explains, in French, how to use this reference database. It is designed to be a practical guide for browsing and searching the database, and particularly for creating search profiles adapted to the needs of researchers.

Biological basis for space-variant sensor design I: parameters of monkey and human spatial vision

NASA Astrophysics Data System (ADS)

Rojer, Alan S.; Schwartz, Eric L.

1991-02-01

Biological sensor design has long provided inspiration for sensor design in machine vision. However relatively little attention has been paid to the actual design parameters provided by biological systems as opposed to the general nature of biological vision architectures. In the present paper we will provide a review of current knowledge of primate spatial vision design parameters and will present recent experimental and modeling work from our lab which demonstrates that a numerical conformal mapping which is a refinement of our previous complex logarithmic model provides the best current summary of this feature of the primate visual system. In this paper we will review recent work from our laboratory which has characterized some of the spatial architectures of the primate visual system. In particular we will review experimental and modeling studies which indicate that: . The global spatial architecture of primate visual cortex is well summarized by a numerical conformal mapping whose simplest analytic approximation is the complex logarithm function . The columnar sub-structure of primate visual cortex can be well summarized by a model based on a band-pass filtered white noise. We will also refer to ongoing work in our lab which demonstrates that: . The joint columnar/map structure of primate visual cortex can be modeled and summarized in terms of a new algorithm the ''''proto-column'''' algorithm. This work provides a reference-point for current engineering approaches to novel architectures for

Curriculum Style and English Language: An Investigation into Current Practices in the Teaching of English Language in Australian Schools. ACER Research Monograph No. 19.

ERIC Educational Resources Information Center

Piper, Kevin

Intended for English teachers and administrators involved in curriculum design, this monograph describes the Language Learning Project, an investigation into current school practices in the teaching of English language in the Australian junior secondary school, with particular reference to teaching directed toward the attainment of language…

Modeling Lost-Particle Backgrounds in PEP-II Using LPTURTLE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fieguth, T.; /SLAC; Barlow, R.

2005-05-17

Background studies during the design, construction, commissioning, operation and improvement of BaBar and PEP-II have been greatly influenced by results from a program referred to as LPTURTLE (Lost Particle TURTLE) which was originally conceived for the purpose of studying gas background for SLC. This venerable program is still in use today. We describe its use, capabilities and improvements and refer to current results now being applied to BaBar.

Multi-point Adjoint-Based Design of Tilt-Rotors in a Noninertial Reference Frame

NASA Technical Reports Server (NTRS)

Jones, William T.; Nielsen, Eric J.; Lee-Rausch, Elizabeth M.; Acree, Cecil W.

2014-01-01

Optimization of tilt-rotor systems requires the consideration of performance at multiple design points. In the current study, an adjoint-based optimization of a tilt-rotor blade is considered. The optimization seeks to simultaneously maximize the rotorcraft figure of merit in hover and the propulsive efficiency in airplane-mode for a tilt-rotor system. The design is subject to minimum thrust constraints imposed at each design point. The rotor flowfields at each design point are cast as steady-state problems in a noninertial reference frame. Geometric design variables used in the study to control blade shape include: thickness, camber, twist, and taper represented by as many as 123 separate design variables. Performance weighting of each operational mode is considered in the formulation of the composite objective function, and a build up of increasing geometric degrees of freedom is used to isolate the impact of selected design variables. In all cases considered, the resulting designs successfully increase both the hover figure of merit and the airplane-mode propulsive efficiency for a rotor designed with classical techniques.

Content Analysis of Virtual Reference Data: Reshaping Library Website Design.

PubMed

Fan, Suhua Caroline; Welch, Jennifer M

2016-01-01

An academic health sciences library wanted to redesign its website to provide better access to health information in the community. Virtual reference data were used to provide information about user searching behavior. This study analyzed three years (2012-2014) of virtual reference data, including e-mail questions, text messaging, and live chat transcripts, to evaluate the library website for redesigning, especially in areas such as the home page, patrons' terminology, and issues prompting patrons to ask for help. A coding system based on information links in the current library website was created to analyze the data.

Document for 270 Voltage Direct Current (270 V dc) System

NASA Astrophysics Data System (ADS)

1992-09-01

The paper presents the technical design and application information established by the SAE Aerospace Recommended Practice concerning the generation, distribution, control, and utilization of aircraft 270 V dc electrical power systems and support equipment. Also presented are references and definitions making it possible to compare various electrical systems and components. A diagram of the generic 270 V Direct Current High-Voltage Direct System is included.

A Reference Architecture for Space Information Management

NASA Technical Reports Server (NTRS)

Mattmann, Chris A.; Crichton, Daniel J.; Hughes, J. Steven; Ramirez, Paul M.; Berrios, Daniel C.

2006-01-01

We describe a reference architecture for space information management systems that elegantly overcomes the rigid design of common information systems in many domains. The reference architecture consists of a set of flexible, reusable, independent models and software components that function in unison, but remain separately managed entities. The main guiding principle of the reference architecture is to separate the various models of information (e.g., data, metadata, etc.) from implemented system code, allowing each to evolve independently. System modularity, systems interoperability, and dynamic evolution of information system components are the primary benefits of the design of the architecture. The architecture requires the use of information models that are substantially more advanced than those used by the vast majority of information systems. These models are more expressive and can be more easily modularized, distributed and maintained than simpler models e.g., configuration files and data dictionaries. Our current work focuses on formalizing the architecture within a CCSDS Green Book and evaluating the architecture within the context of the C3I initiative.

Design Automation Using Script Languages. High-Level CAD Templates in Non-Parametric Programs

NASA Astrophysics Data System (ADS)

Moreno, R.; Bazán, A. M.

2017-10-01

The main purpose of this work is to study the advantages offered by the application of traditional techniques of technical drawing in processes for automation of the design, with non-parametric CAD programs, provided with scripting languages. Given that an example drawing can be solved with traditional step-by-step detailed procedures, is possible to do the same with CAD applications and to generalize it later, incorporating references. In today’s modern CAD applications, there are striking absences of solutions for building engineering: oblique projections (military and cavalier), 3D modelling of complex stairs, roofs, furniture, and so on. The use of geometric references (using variables in script languages) and their incorporation into high-level CAD templates allows the automation of processes. Instead of repeatedly creating similar designs or modifying their data, users should be able to use these templates to generate future variations of the same design. This paper presents the automation process of several complex drawing examples based on CAD script files aided with parametric geometry calculation tools. The proposed method allows us to solve complex geometry designs not currently incorporated in the current CAD applications and to subsequently create other new derivatives without user intervention. Automation in the generation of complex designs not only saves time but also increases the quality of the presentations and reduces the possibility of human errors.

Parametric Criticality Safety Calculations for Arrays of TRU Waste Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gough, Sean T.

The Nuclear Criticality Safety Division (NCSD) has performed criticality safety calculations for finite and infinite arrays of transuranic (TRU) waste containers. The results of these analyses may be applied in any technical area onsite (e.g., TA-54, TA-55, etc.), as long as the assumptions herein are met. These calculations are designed to update the existing reference calculations for waste arrays documented in Reference 1, in order to meet current guidance on calculational methodology.

Circuit design and simulation of a transmit beamforming ASIC for high-frequency ultrasonic imaging systems.

PubMed

Athanasopoulos, Georgios I; Carey, Stephen J; Hatfield, John V

2011-07-01

This paper describes the design of a programmable transmit beamformer application-specific integrated circuit (ASIC) with 8 channels for ultrasound imaging systems. The system uses a 20-MHz reference clock. A digital delay-locked loop (DLL) was designed with 50 variable delay elements, each of which provides a clock with different phase from a single reference. Two phase detectors compare the phase difference of the reference clock with the feedback clock, adjusting the delay of the delay elements to bring the feedback clock signal in phase with the reference clock signal. Two independent control voltages for the delay elements ensure that the mark space ratio of the pulses remain at 50%. By combining a 10- bit asynchronous counter with the delays from the DLL, each channel can be programmed to give a maximum time delay of 51 μs with 1 ns resolution. It can also give bursts of up to 64 pulses. Finally, for a single pulse, it can adjust the pulse width between 9 ns and 100 ns by controlling the current flowing through a capacitor in a one-shot circuit, for use with 40-MHz and 5-MHz transducers, respectively.

Emotional Skills-Building Curriculum

ERIC Educational Resources Information Center

Pickover, Sheri

2010-01-01

Current anger management programs use a cognitive behavior perspective; however, research also links anger control to developmental deficits such as attachment insecurity and emotional regulation. This article previews the Emotional Skills-Building Curriculum (ESBC), a 13-week treatment program designed to treat individuals who are referred for…

Automotive Stirling Engine Development Program

NASA Technical Reports Server (NTRS)

Nightingale, N.; Ernst, W.; Richey, A.; Simetkosky, M.; Smith, G.; Rohdenburg, C.; Antonelli, M. (Editor)

1983-01-01

Program status and plans are discussed for component and technology development; reference engine system design, the upgraded Mod 1 engine; industry test and evaluation; and product assurance. Four current Mod 1 engines reached a total of 2523 operational hours, while two upgraded engines accumulated 166 hours.

Low-power low-voltage superior-order curvature corrected voltage reference

NASA Astrophysics Data System (ADS)

Popa, Cosmin

2010-06-01

A complementary metal oxide semiconductor (CMOS) voltage reference with a logarithmic curvature-correction will be presented. The first-order compensation is realised using an original offset voltage follower (OVF) block as a proportional to absolute temperature (PTAT) voltage generator, with the advantages of reducing the silicon area and of increasing accuracy by replacing matched resistors with matched transistors. The new logarithmic curvature-correction technique will be implemented using an asymmetric differential amplifier (ADA) block for compensating the logarithmic temperature dependent term from the first-order compensated voltage reference. In order to increase the circuit accuracy, an original temperature-dependent current generator will be designed for computing the exact type of the implemented curvature-correction. The relatively small complexity of the current squarer allows an important increasing of the circuit accuracy that could be achieved by increasing the current generator complexity. As a result of operating most of the MOS transistors in weak inversion, the original proposed voltage reference could be valuable for low-power applications. The circuit is implemented in 0.35 μm CMOS technology and consumes only 60μA for t = 25°C, being supplied at the minimal supply voltage V DD = 1.75V. The temperature coefficient of the reference voltage is 8.7 ppm/°C, while the line sensitivity is 0.75 mV/V for a supply voltage between 1.75 V and 7 V.

An ultra-stable optical frequency reference for space

NASA Astrophysics Data System (ADS)

Schuldt, T.; Döringshoff, K.; Kovalchuk, E.; Pahl, J.; Gohlke, M.; Weise, D.; Johann, U.; Peters, A.; Braxmaier, C.

2017-11-01

We realized ultra-stable optical frequency references on elegant breadboard (EBB) and engineering model (EM) level utilizing Doppler-free spectroscopy of molecular iodine near 532nm. A frequency stability of about 1•10-14 at an integration time of 1 s and below 5•10-15 at integration times between 10 s and 100 s was achieved. These values are comparable to the currently best laboratory setups. Both setups use a baseplate made of glass material where the optical components are joint using a specific assembly-integration technology. Compared to the EBB setup, the EM setup is further developed with respect to compactness and mechanical and thermal stability. The EM setup uses a baseplate made of fused silica with dimensions of 380 x 180 x 40 mm3 and a specifically designed 100 x 100 x 30 mm3 rectangular iodine cell in nine-pass configuration with a specific robust cold finger design. The EM setup was subjected to thermal cycling and vibrational testing. Applications of such an optical frequency reference in space can be found in fundamental physics, geoscience, Earth observation, and navigation & ranging. One example is the proposed mSTAR (mini SpaceTime Asymmetry Research) mission, dedicated to perform a Kennedy-Thorndike experiment on a satellite in a sunsynchronous low-Earth orbit. By comparing an iodine standard to a cavity-based frequency reference and integration over 2 year mission lifetime, the Kennedy-Thorndike coefficient will be determined with up to two orders of magnitude higher accuracy than the current best ground experiment. In a current study, the compatibility of the payload with the SaudiSat-4 host vehicle is investigated.

Conference Proceedings on Validation of Computational Fluid Dynamics. Volume 2. Poster Papers Held in Lisbon, Portugal on 2-5 May 1988

DTIC Science & Technology

1988-05-01

ifforiable manpower investement. On the basis of our current experience it seems that the basic design principles are valid. The system developed will... system is operational on various computer networks, and in both industrial and in research environments. The design pri,lciples for the construction of...to a useful numerical simulation and design system for very complex configurations and flows. 7. REFERENCES 1. Bartlett G. W. , "An experimental

Lightning protection for aircraft

NASA Technical Reports Server (NTRS)

Fisher, F. A.; Plumer, J. A.

1980-01-01

Reference book summarizes current knowledge concerning potential lightning effects on aircraft and means available to designers and operators to protect against effects. Book is available because of increasing use of nonmetallic materials in aircraft structural components and use of electronic equipment for control of critical flight operations and navigation.

Bibliographic Instruction and the Development of Online Catalogs.

ERIC Educational Resources Information Center

McDonald, David R.; Searing, Susan E.

1983-01-01

Discusses the definition of an online library catalog; five factors to be considered by the online catalog designer; user-computer communication (error messages, help screens, prompts, unnatural language); online tutorials and offline instruction offered by bibliographic instruction librarians; and the current situation. Nine references are…

Integrating Sensor Monitoring Technology into the Current Air Pollution Regulatory Support Paradigm: Practical Considerations

EPA Science Inventory

The US Environmental Protection Agency (EPA) along with state, local, and tribal governments operate Federal Reference Method (FRM) and Federal Equivalent Method (FEM) instruments to assess compliance with US air pollution standards designed to protect human and ecosystem health....

D Imaging for Museum Artefacts: a Portable Test Object for Heritage and Museum Documentation of Small Objects

NASA Astrophysics Data System (ADS)

Hess, M.; Robson, S.

2012-07-01

3D colour image data generated for the recording of small museum objects and archaeological finds are highly variable in quality and fitness for purpose. Whilst current technology is capable of extremely high quality outputs, there are currently no common standards or applicable guidelines in either the museum or engineering domain suited to scientific evaluation, understanding and tendering for 3D colour digital data. This paper firstly explains the rationale towards and requirements for 3D digital documentation in museums. Secondly it describes the design process, development and use of a new portable test object suited to sensor evaluation and the provision of user acceptance metrics. The test object is specifically designed for museums and heritage institutions and includes known surface and geometric properties which support quantitative and comparative imaging on different systems. The development for a supporting protocol will allow object reference data to be included in the data processing workflow with specific reference to conservation and curation.

The Jupiter Icy Moons Orbiter reference trajectory

NASA Technical Reports Server (NTRS)

Whiffen, Gregory J.; Lam, Try

2006-01-01

The proposed NASA Jupiter Icy Moons Orbiter (JIMO) mission would have used a single spacecraft to orbit Callisto, Ganymede, and Europa in succession. The enormous Delta-Velocity required for this mission (nearly [25 km/s]) would necessitate the use of very high efficiency electric propulsion. The trajectory created for the proposed baseline JIMO mission may be the most complex trajectory ever designed. This paper describes the current reference trajectory in detail and describes the processes that were used to construct it.

Structural Materials and Fuels for Space Power Plants

NASA Technical Reports Server (NTRS)

Bowman, Cheryl; Busby, Jeremy; Porter, Douglas

2008-01-01

A fission reactor combined with Stirling convertor power generation is one promising candidate in on-going Fission Surface Power (FSP) studies for future lunar and Martian bases. There are many challenges for designing and qualifying space-rated nuclear power plants. In order to have an affordable and sustainable program, NASA and DOE designers want to build upon the extensive foundation in nuclear fuels and structural materials. This talk will outline the current Fission Surface Power program and outline baseline design options for a lunar power plant with an emphasis on materials challenges. NASA first organized an Affordable Fission Surface Power System Study Team to establish a reference design that could be scrutinized for technical and fiscal feasibility. Previous papers and presentations have discussed this study process in detail. Considerations for the reference design included that no significant nuclear technology, fuels, or material development were required for near term use. The desire was to build upon terrestrial-derived reactor technology including conventional fuels and materials. Here we will present an overview of the reference design, Figure 1, and examine the materials choices. The system definition included analysis and recommendations for power level and life, plant configuration, shielding approach, reactor type, and power conversion type. It is important to note that this is just one concept undergoing refinement. The design team, however, understands that materials selection and improvement must be an integral part of the system development.

Alkali Metal Heat Pipe Life Issues

NASA Technical Reports Server (NTRS)

Reid, Robert S.

2004-01-01

One approach to space fission power system design is predicated on the use of alkali metal heat pipes, either as radiator elements, thermal management components, or as part of the core primary heat-transfer system. This synopsis characterizes long-life core heat pipes. References are included where more detailed information can be found. Specifics shown here are for demonstrational purposes and do not necessarily reflect current Project Prometheus point designs.

State reference design and saturated control of doubly-fed induction generators under voltage dips

NASA Astrophysics Data System (ADS)

Tilli, Andrea; Conficoni, Christian; Hashemi, Ahmad

2017-04-01

In this paper, the stator/rotor currents control problem of doubly-fed induction generator under faulty line voltage is carried out. Common grid faults cause a steep decline in the line voltage profile, commonly denoted as voltage dip. This point is critical for such kind of machines, having their stator windings directly connected to the grid. In this respect, solid methodological nonlinear control theory arguments are exploited and applied to design a novel controller, whose main goal is to improve the system behaviour during voltage dips, endowing it with low voltage ride through capability, a fundamental feature required by modern Grid Codes. The proposed solution exploits both feedforward and feedback actions. The feedforward part relies on suitable reference trajectories for the system internal dynamics, which are designed to prevent large oscillations in the rotor currents and command voltages, excited by line perturbations. The feedback part uses state measurements and is designed according to Linear Matrix Inequalities (LMI) based saturated control techniques to further reduce oscillations, while explicitly accounting for the system constraints. Numerical simulations verify the benefits of the internal dynamics trajectory planning, and the saturated state feedback action, in crucially improving the Doubly-Fed Induction Machine response under severe grid faults.

Fracture control procedures for aircraft structural integrity

NASA Technical Reports Server (NTRS)

Wood, H. A.

1972-01-01

The application of applied fracture mechanics in the design, analysis, and qualification of aircraft structural systems are reviewed. Recent service experiences are cited. Current trends in high-strength materials application are reviewed with particular emphasis on the manner in which fracture toughness and structural efficiency may affect the material selection process. General fracture control procedures are reviewed in depth with specific reference to the impact of inspectability, structural arrangement, and material on proposed analysis requirements for safe crack growth. The relative impact on allowable design stress is indicated by example. Design criteria, material, and analysis requirements for implementation of fracture control procedures are reviewed together with limitations in current available data techniques. A summary of items which require further study and attention is presented.

Identification and evaluation of reference genes for qRT-PCR normalization in Ganoderma lucidum.

PubMed

Xu, Jiang; Xu, ZhiChao; Zhu, YingJie; Luo, HongMei; Qian, Jun; Ji, AiJia; Hu, YuanLei; Sun, Wei; Wang, Bo; Song, JingYuan; Sun, Chao; Chen, ShiLin

2014-01-01

Quantitative real-time reverse transcription PCR (qRT-PCR) is a rapid, sensitive, and reliable technique for gene expression studies. The accuracy and reliability of qRT-PCR results depend on the stability of the reference genes used for gene normalization. Therefore, a systematic process of reference gene evaluation is needed. Ganoderma lucidum is a famous medicinal mushroom in East Asia. In the current study, 10 potential reference genes were selected from the G. lucidum genomic data. The sequences of these genes were manually curated, and primers were designed following strict criteria. The experiment was conducted using qRT-PCR, and the stability of each candidate gene was assessed using four commonly used statistical programs-geNorm, NormFinder, BestKeeper, and RefFinder. According to our results, PP2A was expressed at the most stable levels under different fermentation conditions, and RPL4 was the most stably expressed gene in different tissues. RPL4, PP2A, and β-tubulin are the most commonly recommended reference genes for normalizing gene expression in the entire sample set. The current study provides a foundation for the further use of qRT-PCR in G. lucidum gene analysis.

Bibliographic Utilities and the Use of Microcomputers in Libraries: Current and Projected Practices.

ERIC Educational Resources Information Center

McAninch, Glen

1986-01-01

Bibliographic utilities are marketing specially designed hardware and software that permit libraries to patch together automated cataloging, acquisitions, serials control, reference, online public catalogs, circulation, interlibrary loan, and administrative functions. The increasing complexity of the technology is making it more difficult to…

A Selected Bibliography of On-Line Visual Displays and Their Applications.

ERIC Educational Resources Information Center

Braidwood, J.

Contained in this bibliography are 312 references as they related to general principles and problems of information display, man-computer interaction, present and possible future display equipment, ergonomic aspects of display design, and current and potential applications, especially to information processing. (Author/MM)

ASHE Reader on Academic Programs in Colleges and Universities.

ERIC Educational Resources Information Center

Conrad, Clifton F., Ed.

Historical and philosophical perspectives on college academic programs, current curriculum practices and agendas, and academic program development and implementation are considered in 20 articles in a reader designed for graduate classes in higher education administration. Titles and authors are as follows: "Frames of Reference" (Frederick…

Resources for Guidance Program Improvement. Volume 2.

ERIC Educational Resources Information Center

Frenza, Mary C., Comp.; and Others

This guide, for guidance personnel and teachers, is designed to provide ready access to current, practical programs, activities, and references for improving guidance programs. The resources are organized in four sections representing areas of basic concern for guidance personnel. Section 1 presents selected portions of guidance programs from…

An improved synchronous reference frame current control strategy for a photovoltaic grid-connected inverter under unbalanced and nonlinear load conditions.

PubMed

Naderipour, Amirreza; Asuhaimi Mohd Zin, Abdullah; Bin Habibuddin, Mohd Hafiz; Miveh, Mohammad Reza; Guerrero, Josep M

2017-01-01

In recent years, renewable energy sources have been considered the most encouraging resources for grid and off-grid power generation. This paper presents an improved current control strategy for a three-phase photovoltaic grid-connected inverter (GCI) under unbalanced and nonlinear load conditions. It is challenging to suppress the harmonic content in the output current below a pre-set value in the GCI. It is also difficult to compensate for unbalanced loads even when the grid is under disruption due to total harmonic distortion (THD) and unbalanced loads. The primary advantage and objective of this method is to effectively compensate for the harmonic current content of the grid current and microgrid without the use of any compensation devices, such as active and passive filters. This method leads to a very low THD in both the GCI currents and the current exchanged with the grid. The control approach is designed to control the active and reactive power and harmonic current compensation, and it also corrects the system unbalance. The proposed control method features the synchronous reference frame (SRF) method. Simulation results are presented to demonstrate the effective performance of the proposed method.

An improved synchronous reference frame current control strategy for a photovoltaic grid-connected inverter under unbalanced and nonlinear load conditions

PubMed Central

Naderipour, Amirreza; Asuhaimi Mohd Zin, Abdullah; Bin Habibuddin, Mohd Hafiz; Miveh, Mohammad Reza; Guerrero, Josep M.

2017-01-01

In recent years, renewable energy sources have been considered the most encouraging resources for grid and off-grid power generation. This paper presents an improved current control strategy for a three-phase photovoltaic grid-connected inverter (GCI) under unbalanced and nonlinear load conditions. It is challenging to suppress the harmonic content in the output current below a pre-set value in the GCI. It is also difficult to compensate for unbalanced loads even when the grid is under disruption due to total harmonic distortion (THD) and unbalanced loads. The primary advantage and objective of this method is to effectively compensate for the harmonic current content of the grid current and microgrid without the use of any compensation devices, such as active and passive filters. This method leads to a very low THD in both the GCI currents and the current exchanged with the grid. The control approach is designed to control the active and reactive power and harmonic current compensation, and it also corrects the system unbalance. The proposed control method features the synchronous reference frame (SRF) method. Simulation results are presented to demonstrate the effective performance of the proposed method. PMID:28192436

An Earth-Moon System Trajectory Design Reference Catalog

NASA Technical Reports Server (NTRS)

Folta, David; Bosanac, Natasha; Guzzetti, Davide; Howell, Kathleen C.

2014-01-01

As demonstrated by ongoing concept designs and the recent ARTEMIS mission, there is, currently, significant interest in exploiting three-body dynamics in the design of trajectories for both robotic and human missions within the Earth-Moon system. The concept of an interactive and 'dynamic' catalog of potential solutions in the Earth-Moon system is explored within this paper and analyzed as a framework to guide trajectory design. Characterizing and compiling periodic and quasi-periodic solutions that exist in the circular restricted three-body problem may offer faster and more efficient strategies for orbit design, while also delivering innovative mission design parameters for further examination.

Human Health and Performance Aspects of the Mars Design Reference Mission

NASA Technical Reports Server (NTRS)

Charles, John B.

2000-01-01

This paper will describe the current planning for exploration-class missions, emphasizing the medical, and human factors aspects of such expeditions. The details of mission architecture are still under study, but a typical Mars design reference mission comprises a six-month transit from Earth to Mar, eighteen months in residence on Mars, and a six-month transit back to Earth. Physiological stressors will include environmental factors such as prolonged exposure to radiation, weightlessness in transit, and hypogravity and a toxic atmosphere while on Mars. Psychological stressors will include remoteness from Earth, confinement, and potential interpersonal conflicts, all complicated by circadian alterations. Medical risks including trauma must also be considered. Results of planning for assuring human health and performance will be presented.

Air Pollution and Industry.

ERIC Educational Resources Information Center

Ross, R. D., Ed.

This book is an authoritative reference and practical guide designed to help the plant engineer identify and solve industrial air pollution problems in order to be able to meet current air pollution regulations. Prepared under the editorial supervision of an experienced chemical engineer, with each chapter contributed by an expert in his field,…

Drug Dependence and Abuse: A Selected Bibliography.

ERIC Educational Resources Information Center

National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

This selected list of references is designed to provide an introduction to both scientific and popular drug abuse literature. Criteria for selection are presented and include: (1) 1969 or 1970 books by recognized and authoritative writers, (2) current and responsible research, (3) classic books, articles and studies, and (4) factual popular…

Applying Cognitive Psychology Based Instructional Design Principles in Mathematics Teaching and Learning: Introduction

ERIC Educational Resources Information Center

Verschaffel, Lieven; Van Dooren, W.; Star, J.

2017-01-01

This special issue comprises contributions that address the breadth of current lines of recent research from cognitive psychology that appear promising for positively impacting students' learning of mathematics. More specifically, we included contributions (a) that refer to cognitive psychology based principles and techniques, such as explanatory…

Floral Design and Marketing.

ERIC Educational Resources Information Center

Anderson, Gary A.

This profusely illustrated, 32 chapter book surveys retail floriculutre and makes a current statement of the industry. It can be used by students pursuing individualized study, in a classroom with instructor reinforcement and demonstrations, and by a former student or flower shop employee as a refresher tool and reference. Principles of flower…

A User Interface for Multiple Retrieval Systems.

ERIC Educational Resources Information Center

Teskey, Niall; And Others

1987-01-01

Reviews current systems designed to help end-users search online databases without the assistance of an intermediary and describes a prototype system which emulates the Deco (the text storage and retrieval system used by Unilever) interface on Dialog and Data-Star. Initial trials of the prototype system are reported. (15 references) (MES)

Mobile Digest of Education Statistics, 2013. NCES 2014-086

ERIC Educational Resources Information Center

Snyder, Thomas D.

2014-01-01

This is the first edition of the "Mobile Digest of Education Statistics." This compact compilation of statistical information covers prekindergarten through graduate school to describe the current American education scene. The "Mobile Digest" is designed as an easy mobile reference for materials found in detail in the…

A Study of 4-level DC-DC Boost Inverter with Passive Component Reduction Consideration

NASA Astrophysics Data System (ADS)

Kasiran, A. N.; Ponniran, A.; Harimon, M. A.; Hamzah, H. H.

2018-04-01

This study is to analyze design principles of boost inductor and capacitor used in the 4-level DC-DC boost converter to realize size reduction of passive component referring to their attributes. The important feature of this circuit is that most of the boost-up energy is transferred from the capacitor-clamped to the output side which the small inductance can be used at the input side. The inductance of the boost inductor is designed by referring the inductor current ripple. On the other hand, the capacitance of the capacitor-clamped is designed by considering voltage stress on semiconductor devices and also the used switching frequency. Besides that, according to the design specifications, the required inductance in 4-level DC-DC boost converter is decreased compared to a conventional conventional DC-DC boost converter. Meanwhile, voltage stress on semiconductor device is depending on the maximum voltage ripple of the capacitor-clamped. A 50 W 4-level DC-DC boost converter prototype has been constructed. The results show that the inductor current ripple was 1.15 A when the inductors, 1 mH and 0.11 mH were used in the conventional and 4-level DC-DC boost converters, respectively. Thus, based on the experimental results, it shows that the reduction of passive components by referring to their attributes in 4-level DC-DC boost converter is achieved. Moreover, the decreasing of voltage stress on the semiconductor devices is an advantage for the selection of low ON-resistance of the devices which will contribute to the reduction of the semiconductor conduction loss. The integration result of boost converter and H-bridge inverter is also shown.

Facial measurements for frame design.

PubMed

Tang, C Y; Tang, N; Stewart, M C

1998-04-01

Anthropometric data for the purpose of spectacle frame design are scarce in the literature. Definitions of facial features to be measured with existing systems of facial measurement are often not specific enough for frame design and manufacturing. Currently, for individual frame design, experienced personnel collect data with facial rules or instruments. A new measuring system is proposed, making use of a template in the form of a spectacle frame. Upon fitting the template onto a subject, most of the measuring references can be defined. Such a system can be administered by lesser-trained personnel and can be used for researches covering a larger population.

Phase-locked loop design with fast-digital-calibration charge pump

NASA Astrophysics Data System (ADS)

Wang, San-Fu; Hwang, Tsuen-Shiau; Wang, Jhen-Ji

2016-02-01

A fast-digital-calibration technique is proposed for reducing current mismatch in the charge pump (CP) of a phase-locked loop (PLL). The current mismatch in the CP generates fluctuations, which is transferred to the input of voltage-controlled oscillator (VCO). Therefore, the current mismatch increases the reference spur in the PLL. Improving current match of CP will reduce the reference spur and decrease the static phase offset of PLLs. Moreover, the settling time, ripple and power consumption of the PLL are also improved by the proposed technique. This study evaluated a 2.27-2.88 GHz frequency synthesiser fabricated in TSMC 0.18 μm CMOS 1.8 V process. The tuning range of proposed VCO is about 26%. By using the fast-digital-calibration technique, current mismatch is reduced to lower than 0.97%, and the operation range of the proposed CP is between 0.2 and 1.6 V. The proposed PLL has a total power consumption of 22.57 mW and a settling time of 10 μs or less.

Waste Handling and Emplacement Options for Disposal of Radioactive Waste in Deep Boreholes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.; Hardin, Ernest

2015-11-01

Traditional methods cannot be used to handle and emplace radioactive wastes in boreholes up to 16,400 feet (5 km) deep for disposal. This paper describes three systems that can be used for handling and emplacing waste packages in deep borehole: (1) a 2011 reference design that is based on a previous study by Woodward–Clyde in 1983 in which waste packages are assembled into “strings” and lowered using drill pipe; (2) an updated version of the 2011 reference design; and (3) a new concept in which individual waste packages would be lowered to depth using a wireline. Emplacement on coiled tubingmore » was also considered, but not developed in detail. The systems described here are currently designed for U.S. Department of Energy-owned high-level waste (HLW) including the Cesium- 137/Strontium-90 capsules from the Hanford Facility and bulk granular HLW from fuel processing in Idaho.« less

A knowledge-based system for patient image pre-fetching in heterogeneous database environments--modeling, design, and evaluation.

PubMed

Wei, C P; Hu, P J; Sheng, O R

2001-03-01

When performing primary reading on a newly taken radiological examination, a radiologist often needs to reference relevant prior images of the same patient for confirmation or comparison purposes. Support of such image references is of clinical importance and may have significant effects on radiologists' examination reading efficiency, service quality, and work satisfaction. To effectively support such image reference needs, we proposed and developed a knowledge-based patient image pre-fetching system, addressing several challenging requirements of the application that include representation and learning of image reference heuristics and management of data-intensive knowledge inferencing. Moreover, the system demands an extensible and maintainable architecture design capable of effectively adapting to a dynamic environment characterized by heterogeneous and autonomous data source systems. In this paper, we developed a synthesized object-oriented entity- relationship model, a conceptual model appropriate for representing radiologists' prior image reference heuristics that are heuristic oriented and data intensive. We detailed the system architecture and design of the knowledge-based patient image pre-fetching system. Our architecture design is based on a client-mediator-server framework, capable of coping with a dynamic environment characterized by distributed, heterogeneous, and highly autonomous data source systems. To adapt to changes in radiologists' patient prior image reference heuristics, ID3-based multidecision-tree induction and CN2-based multidecision induction learning techniques were developed and evaluated. Experimentally, we examined effects of the pre-fetching system we created on radiologists' examination readings. Preliminary results show that the knowledge-based patient image pre-fetching system more accurately supports radiologists' patient prior image reference needs than the current practice adopted at the study site and that radiologists may become more efficient, consultatively effective, and better satisfied when supported by the pre-fetching system than when relying on the study site's pre-fetching practice.

Design and Implementation of a High-Power Resonant DC-DC Converter Module for a Reduced-Scale Prototype Integrated Power System

DTIC Science & Technology

2001-09-01

damping RC network . The filter was designed to have a pole pair (~450 Hz) above the 360 Hz ripple of the six-pulse rectified DC supply but well below the...Circuit With Input Filtering Included. The damping network was designed using the guidance provided in reference [24] and its function is to lower the...converter as a linear network and estimated the spectrum envelope by multiplying the Fourier transform of the current waveform by the transfer

Digital current regulator for proportional electro-hydraulic valves with unknown disturbance rejection.

PubMed

Canuto, Enrico; Acuña-Bravo, Wilber; Agostani, Marco; Bonadei, Marco

2014-07-01

Solenoid current regulation is well-known and standard in any proportional electro-hydraulic valve. The goal is to provide a wide-band transfer function from the reference to the measured current, thus making the solenoid a fast and ideal force actuator within the limits of the power supplier. The power supplier is usually a Pulse Width Modulation (PWM) amplifier fixing the voltage bound and the Nyquist frequency of the regulator. Typical analog regulators include three main terms: a feedforward channel, a proportional feedback channel and the electromotive force compensation. The latter compensation may be accomplished by integrative feedback. Here the problem is faced through a model-based design (Embedded Model Control), on the basis of a wide-band embedded model of the solenoid which includes the effect of eddy currents. To this end model parameters must be identified. The embedded model includes a stochastic disturbance dynamics capable of estimating and correcting the electromotive contribution together with parametric uncertainty, variability and state dependence. The embedded model which is fed by the measured current and the supplied voltage becomes a state predictor of the controllable and disturbance dynamics. The control law combines reference generator, state feedback and disturbance rejection to dispatch the PWM amplifier with the appropriate duty cycle. Modeling, identification and control design are outlined together with experimental result. Comparison with an existing analog regulator is also provided. © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

Synthesis study of nondestructive testing devices for use in overlay thickness design of flexible pavements

NASA Astrophysics Data System (ADS)

Smith, R. E.; Lytton, R. L.

1984-04-01

A ready reference for highway engineers who are interested in purchasing nondestructive testing (NDT) equipment for use in designing overlays for flexible pavements was prepared. All commercially available equipment is described. Information includes basic descriptions plus current prices quoted by the manufacturers/distributors. To determine user comments, a questionnaire was sent to nine State agencies, and one Federal agency. The responses to these questionnaires are summarized. Overlay thickness design procedures for flexible pavements are reviewed. Important components related to the use of NDT deflection measuremnts in overlay design are identified and addressed. Summary tables of equipment characteristics and overlay design procedures are presented.

The importance of reference materials in doping-control analysis.

PubMed

Mackay, Lindsey G; Kazlauskas, Rymantas

2011-08-01

Currently a large range of pure substance reference materials are available for calibration of doping-control methods. These materials enable traceability to the International System of Units (SI) for the results generated by World Anti-Doping Agency (WADA)-accredited laboratories. Only a small number of prohibited substances have threshold limits for which quantification is highly important. For these analytes only the highest quality reference materials that are available should be used. Many prohibited substances have no threshold limits and reference materials provide essential identity confirmation. For these reference materials the correct identity is critical and the methods used to assess identity in these cases should be critically evaluated. There is still a lack of certified matrix reference materials to support many aspects of doping analysis. However, in key areas a range of urine matrix materials have been produced for substances with threshold limits, for example 19-norandrosterone and testosterone/epitestosterone (T/E) ratio. These matrix-certified reference materials (CRMs) are an excellent independent means of checking method recovery and bias and will typically be used in method validation and then regularly as quality-control checks. They can be particularly important in the analysis of samples close to threshold limits, in which measurement accuracy becomes critical. Some reference materials for isotope ratio mass spectrometry (IRMS) analysis are available and a matrix material certified for steroid delta values is currently under production. In other new areas, for example the Athlete Biological Passport, peptide hormone testing, designer steroids, and gene doping, reference material needs still need to be thoroughly assessed and prioritised.

Large Synoptic Survey Telescope: From Science Drivers to Reference Design

DTIC Science & Technology

2008-01-01

faint time domain. The LSST design is driven by four main science themes: constraining dark energy and dark matter , taking an inventory of the Solar...Energy and Dark Matter (2) Taking an Inventory of the Solar System (3) Exploring the Transient Optical Sky (4) Mapping the Milky Way Each of these four...Constraining Dark Energy and Dark Matter Current models of cosmology require the exis- tence of both dark matter and dark energy to match observational

Status and Plan for The Upgrade of The CMS Pixel Detector

NASA Astrophysics Data System (ADS)

Lu, Rong-Shyang; CMS Collaboration

2016-04-01

The silicon pixel detector is the innermost component of the CMS tracking system and plays a crucial role in the all-silicon CMS tracker. While the current pixel tracker is designed for and performing well at an instantaneous luminosity of up to 1 ×1034cm-2s-1, it can no longer be operated efficiently at significantly higher values. Based on the strong performance of the LHC accelerator, it is anticipated that peak luminosities of two times the design luminosity are likely to be reached before 2018 and perhaps significantly exceeded in the running period until 2022, referred to as LHC Run 3. Therefore, an upgraded pixel detector, referred to as the phase 1 upgrade, is planned for the year-end technical stop in 2016. With a new pixel readout chip (ROC), an additional fourth layer, two additional endcap disks, and a significantly reduced material budget the upgraded pixel detector will be able to sustain the efficiency of the pixel tracker at the increased requirements imposed by high luminosities and pile-up. The main new features of the upgraded pixel detector will be an ultra-light mechanical design, a digital readout chip with higher rate capability and a new cooling system. These and other design improvements, along with results of Monte Carlo simulation studies for the expected performance of the new pixel detector, will be discussed and compared to those of the current CMS detector.

Innovation in Information Technology: Theoretical and Empirical Study in SMQR Section of Export Import in Automotive Industry

NASA Astrophysics Data System (ADS)

Edi Nugroho Soebandrija, Khristian; Pratama, Yogi

2014-03-01

This paper has the objective to provide the innovation in information technology in both theoretical and empirical study. Precisely, both aspects relate to the Shortage Mispacking Quality Report (SMQR) Claims in Export and Import in Automotive Industry. This paper discusses the major aspects of Innovation, Information Technology, Performance and Competitive Advantage. Furthermore, In the empirical study of PT. Astra Honda Motor (AHM) refers to SMQR Claims, Communication Systems, Analysis and Design Systems. Briefly both aspects of the major aspects and its empirical study are discussed in the Introduction Session. Furthermore, the more detail discussion is conducted in the related aspects in other sessions of this paper, in particular in Literature Review in term classical and updated reference of current research. The increases of SMQR claim and communication problem at PT. Astra Daihatsu Motor (PT. ADM) which still using the email cause the time of claim settlement become longer and finally it causes the rejected of SMQR claim by supplier. With presence of this problem then performed to design the integrated communication system to manage the communication process of SMQR claim between PT. ADM with supplier. The systems was analyzed and designed is expected to facilitate the claim communication process so that can be run in accordance with the procedure and fulfill the target of claim settlement time and also eliminate the difficulties and problems on the previous manual communication system with the email. The design process of the system using the approach of system development life cycle method by Kendall & Kendall (2006)which design process covers the SMQR problem communication process, judgment process by the supplier, claim process, claim payment process and claim monitoring process. After getting the appropriate system designs for managing the SMQR claim, furthermore performed the system implementation and can be seen the improvement in claim communication process and settlement time become faster and achieve the target. The conclusion in this paper comprises two major aspects. The first one refers to the conclusion in term of theory and concept. The second one refers to the conclusion in term of the empirical study of one of automotive industries in Indonesia. Both of them are expected to have contribution in current and future research of related aspects that are discussed in this paper.

A System for Multiplexed Direct Electrical Detection of DNA Synthesis.

PubMed

Anderson, Erik P; Daniels, Jonathan S; Yu, Heng; Karhanek, Miloslav; Lee, Thomas H; Davis, Ronald W; Pourmand, Nader

2008-01-29

An electronic system for the multiplexed detection of DNA polymerization is designed and characterized. DNA polymerization is detected by the measurement of small transient currents arising from ion diffusion during polymerization. A transimpedance amplifier is used to detect these small currents; we implemented a twenty-four channel recording system on a single printed circuit board. Various contributions to the input-referred current noise are analyzed and characterized, as it limits the minimum detectable current and thus the biological limit of detection. We obtained 8.5 pA RMS mean noise current (averaged over all 24 channels) over the recording bandwidth (DC to 2 kHz). With digital filtering, the input-referred current noise of the acquisition system is reduced to 2.4 pA, which is much lower than the biological noise. Electrical crosstalk between channels is measured, and a model for the crosstalk is presented. Minimizing the crosstalk is critical because it can lead to erroneous microarray data. With proper precautions, crosstalk is reduced to a negligible value (less than 1.4%). Using a micro-fabricated array of 24 gold electrodes, we demonstrated system functionality by detecting the presence of a target DNA oligonucleotide which hybridized onto its corresponding target.

Selection of the initial design for the two-stage continual reassessment method.

PubMed

Jia, Xiaoyu; Ivanova, Anastasia; Lee, Shing M

2017-01-01

In the two-stage continual reassessment method (CRM), model-based dose escalation is preceded by a pre-specified escalating sequence starting from the lowest dose level. This is appealing to clinicians because it allows a sufficient number of patients to be assigned to each of the lower dose levels before escalating to higher dose levels. While a theoretical framework to build the two-stage CRM has been proposed, the selection of the initial dose-escalating sequence, generally referred to as the initial design, remains arbitrary, either by specifying cohorts of three patients or by trial and error through extensive simulations. Motivated by a currently ongoing oncology dose-finding study for which clinicians explicitly stated their desire to assign at least one patient to each of the lower dose levels, we proposed a systematic approach for selecting the initial design for the two-stage CRM. The initial design obtained using the proposed algorithm yields better operating characteristics compared to using a cohort of three initial design with a calibrated CRM. The proposed algorithm simplifies the selection of initial design for the two-stage CRM. Moreover, initial designs to be used as reference for planning a two-stage CRM are provided.

The Evolution of SCORM to Tin Can API: Implications for Instructional Design

ERIC Educational Resources Information Center

Lindert, Lisa; Su, Bude

2016-01-01

Integrating and documenting formal and informal learning experiences is challenging using the current Shareable Content Object Reference Model (SCORM) eLearning standard, which limits the media and data that are obtained from eLearning. In response to SCORM's limitations, corporate, military, and academic institutions have collaborated to develop…

Evaluating Impact of Small-Group Discussion on Learning Utilizing a Classroom Response System

ERIC Educational Resources Information Center

Flosason, Thorhallur O.; McGee, Heather M.; Diener-Ludwig, Lori

2015-01-01

Classroom response systems (also referred to as clickers) can enhance learning outcomes and are generally viewed favorably by students and instructors alike. The current study used an alternating treatments design to examine whether discussing questions in small groups before responding to clicker questions during lecture improved accurate…

Sourcebook on Food and Nutrition. Third Edition.

ERIC Educational Resources Information Center

Scarpa, Ioannis S., Ed.; And Others

This four-part book is a compendium of current dietary information and is designed primarily as a reference tool for anyone interested in the field of nutrition. The book's first three parts each contain papers generated from nutrition-related research. Part 1, "Dietary Directions in the 1980s," begins by discussing efforts of major governmental…

Audio-Visual Materials in Adult Consumer Education: An Annotated Bibliography.

ERIC Educational Resources Information Center

Forgue, Raymond E.; And Others

Designed to provide a quick but thorough reference for consumer educators of adults to use when choosing audio-visual materials, this annotated bibliography includes eighty-five titles from the currently available 1,500 films, slidesets, cassettes, records, and transparencies. (Materials were rejected because they were out-of-date; not relevant to…

L'education physique en Suisse Histoire et situation actuelle.

ERIC Educational Resources Information Center

Burgener, Louis

The document presents major aspects of the historical development and current situation of physical education in Switzerland. The study is designed as a manual for education students; as a reference book for educators, youth federations, sports associations, and the press; and as a volume to acquaint foreign readers with particular aspects of the…

Science Curriculum Resource Handbook: A Practical Guide for K-12 Science Curriculum.

ERIC Educational Resources Information Center

Cheek, Dennis W., Ed.; And Others

This handbook is one of a series of practical references for curriculum developers, education faculty, veteran teachers, and student teachers. The handbook is designed to provide basic information on the background of the science curriculum, and current information on publications, standards, and special materials for K-12 science. Part 1 contains…

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 11: PEP, cost, schedules, and work breakdown structure dictionary

NASA Technical Reports Server (NTRS)

1979-01-01

Cost scheduling and funding data are presented for the reference design of the power extension package. Major schedule milestones are correlated with current Spacelab flight dates. Funding distributions provide for minimum expenditure during the first year of the project.

Chocolate Chip Cookies and Rubrics: Helping Students Understand Rubrics in Inclusive Settings.

ERIC Educational Resources Information Center

Hall, Elizabeth Wikfors; Salmon, Susan J.

2003-01-01

This article discusses how teachers can familiarize their students, with and without disabilities, with rubric terminology and the use of rubrics. It addresses why rubrics should be used, designing a rubric, and current uses of rubrics. A chocolate chip cookie rubric is provided as an example. (Contains 7 references.) (CR)

Adjustable electronic load-alarm relay

DOEpatents

Mason, Charles H.; Sitton, Roy S.

1976-01-01

This invention is an improved electronic alarm relay for monitoring the current drawn by an AC motor or other electrical load. The circuit is designed to measure the load with high accuracy and to have excellent alarm repeatability. Chattering and arcing of the relay contacts are minimal. The operator can adjust the set point easily and can re-set both the high and the low alarm points by means of one simple adjustment. The relay includes means for generating a signal voltage proportional to the motor current. In a preferred form of the invention a first operational amplifier is provided to generate a first constant reference voltage which is higher than a preselected value of the signal voltage. A second operational amplifier is provided to generate a second constant reference voltage which is lower than the aforementioned preselected value of the signal voltage. A circuit comprising a first resistor serially connected to a second resistor is connected across the outputs of the first and second amplifiers, and the junction of the two resistors is connected to the inverting terminal of the second amplifier. Means are provided to compare the aforementioned signal voltage with both the first and second reference voltages and to actuate an alarm if the signal voltage is higher than the first reference voltage or lower than the second reference voltage.

Goals, History and Current Programs of Workshop

NASA Technical Reports Server (NTRS)

2001-01-01

Mr. Robert Fusaro, coordinator for the Glenn Research Center Space Mechanisms program, presented the goals of the workshop, history of previous workshops and gave an overview of current space mechanisms work performed by Glenn Research Center. Highlights of his presentation are shown. Following the presentation, Mr. Fusaro demonstrated the new NASA Space Mechanisms Handbook and Reference Guide CD ROM, which was featured as a highlight of the workshop. The handbook is an authoritative guide for design and testing of space mechanisms and related components. Over 600 pages of guidelines written by 25 experts in the field provide in-depth information on how to design space mechanisms and components, including: deployables, release devices, latches, rotating and pointing mechanisms, dampers, motors, gears, fasteners, valves, etc. The handbook provides details on appropriate environmental and tribological testing methods and practices required to evaluate new mechanisms and components. Distribution of the Handbook and Reference Guide is limited by ITAR (International Traffic in Arms Regulations). It is available only to US companies and citizens. A request form for the CD ROM can be found on the Space Mechanisms Project website at http://www.grc.nasa.gov/WWW/spacemech/.

CD-SEM real time bias correction using reference metrology based modeling

NASA Astrophysics Data System (ADS)

Ukraintsev, V.; Banke, W.; Zagorodnev, G.; Archie, C.; Rana, N.; Pavlovsky, V.; Smirnov, V.; Briginas, I.; Katnani, A.; Vaid, A.

2018-03-01

Accuracy of patterning impacts yield, IC performance and technology time to market. Accuracy of patterning relies on optical proximity correction (OPC) models built using CD-SEM inputs and intra die critical dimension (CD) control based on CD-SEM. Sub-nanometer measurement uncertainty (MU) of CD-SEM is required for current technologies. Reported design and process related bias variation of CD-SEM is in the range of several nanometers. Reference metrology and numerical modeling are used to correct SEM. Both methods are slow to be used for real time bias correction. We report on real time CD-SEM bias correction using empirical models based on reference metrology (RM) data. Significant amount of currently untapped information (sidewall angle, corner rounding, etc.) is obtainable from SEM waveforms. Using additional RM information provided for specific technology (design rules, materials, processes) CD extraction algorithms can be pre-built and then used in real time for accurate CD extraction from regular CD-SEM images. The art and challenge of SEM modeling is in finding robust correlation between SEM waveform features and bias of CD-SEM as well as in minimizing RM inputs needed to create accurate (within the design and process space) model. The new approach was applied to improve CD-SEM accuracy of 45 nm GATE and 32 nm MET1 OPC 1D models. In both cases MU of the state of the art CD-SEM has been improved by 3x and reduced to a nanometer level. Similar approach can be applied to 2D (end of line, contours, etc.) and 3D (sidewall angle, corner rounding, etc.) cases.

Design of a three-phase, 15-kilovolt-ampere static inverter for motor-starting a Brayton space power system

NASA Technical Reports Server (NTRS)

Frye, R. J.; Birchenough, A. G.

1971-01-01

The design of a three-phase, 400-Hz, 15-kVA static inverter for motor-starting the 2- to 15-kWe Brayton electrical space power system is described. The inverter operates from a nominal 56-V dc source to provide a 28-V, rms, quasi-square-wave output. The inverter is capable of supplying a 200-A peak current. Integrated circuitry is used to generate the three-phase, 400-Hz reference signals. Performance data for a drive stage that improves switching speed and provides efficient operation over a range of output current and drive supply voltage are presented. A transformerless, transistor output stage is used.

Measurement of LHCD antenna position in Aditya tokamak

NASA Astrophysics Data System (ADS)

Ambulkar, K. K.; Sharma, P. K.; Virani, C. G.; Parmar, P. R.; Thakur, A. L.; Kulkarni, S. V.

2010-02-01

To drive plasma current non-inductively in ADITYA tokamak, 120 kW pulsed Lower Hybrid Current Drive (LHCD) system at 3.7 GHz has been designed, fabricated and installed on ADITYA tokamak. In this system, the antenna consists of a grill structure, having two rows, each row comprising of four sub-waveguides. The coupling of LHCD power to the plasma strongly depends on the plasma density near the mouth of grill antenna. Thus the grill antenna has to be precisely positioned for efficient coupling. The movement of mechanical bellow, which contracts or expands up to 50mm, governs the movement of antenna. In order to monitor the position of the antenna precisely, the reference position of the antenna with respect to the machine/plasma position has to be accurately determined. Further a mechanical system or an electronic system to measure the relative movement of the antenna with respect to the reference position is also desired. Also due to poor accessibility inside the ADITYA machine, it is impossible to measure physically the reference position of the grill antenna with respect to machine wall, taken as reference position and hence an alternative method has to be adopted to establish these measurements reliably. In this paper we report the design and development of a mechanism, using which the antenna position measurements are made. It also describes a unique method employing which the measurements of the reference position of the antenna with respect to the inner edge of the tokamak wall is carried out, which otherwise was impossible due to poor accessibility and physical constraints. The position of the antenna is monitored using an electronic scale, which is developed and installed on the bellow. Once the reference position is derived, the linear potentiometer, attached to the bellow, measures the linear distance using position transmitter. The accuracy of measurement obtained in our setup is within +/- 0.5 % and the linearity, along with repeatability is excellent.

RLE Progress Report Number 122.

DTIC Science & Technology

1980-01-01

generator capable of delivering 20 kA of current at 1.5 MV. Both the pipe and the diode region are immersed in the uniform axial magnetic field of a...it decays into a slow space-charge wave and a TM wave of the guide. The dispersion PR No. 122 100 I ____ W/Wp (wi,ki) BEAM FRAME (a) .. ( 3, k3) ka ...to regular operation with well-confined plasmas and plasma currents of approximately as high as 300 kA . We recall that the reference design value of

Mars Simulant Development for In-Situ Resource Utilization (ISRU) Applications

NASA Technical Reports Server (NTRS)

Ming, Doug

2016-01-01

Current design reference missions for the Evolvable Mars Campaign (EMC) call for the use of in-situ resources to enable human missions to the surface of Mars. One potential resource is water extracted from the Martian regolith. Current Mars' soil analogs (JSC Mars-1) have 5-10 times more water than typical regolith on Mars. Therefore, there is a critical need to develop Mars simulants to be used in ISRU applications that mimic the chemical, mineralogical, and physical properties of the Martian regolith.

SU-E-T-284: Revisiting Reference Dosimetry for the Model S700 Axxent 50 KV{sub p} Electronic Brachytherapy Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hiatt, JR; Rivard, MJ

2014-06-01

Purpose: The model S700 Axxent electronic brachytherapy source by Xoft was characterized in 2006 by Rivard et al. The source design was modified in 2006 to include a plastic centering insert at the source tip to more accurately position the anode. The objectives of the current study were to establish an accurate Monte Carlo source model for simulation purposes, to dosimetrically characterize the new source and obtain its TG-43 brachytherapy dosimetry parameters, and to determine dose differences between the source with and without the centering insert. Methods: Design information from dissected sources and vendor-supplied CAD drawings were used to devisemore » the source model for radiation transport simulations of dose distributions in a water phantom. Collision kerma was estimated as a function of radial distance, r, and polar angle, θ, for determination of reference TG-43 dosimetry parameters. Simulations were run for 10{sup 10} histories, resulting in statistical uncertainties on the transverse plane of 0.03% at r=1 cm and 0.08% at r=10 cm. Results: The dose rate distribution the transverse plane did not change beyond 2% between the 2006 model and the current study. While differences exceeding 15% were observed near the source distal tip, these diminished to within 2% for r>1.5 cm. Differences exceeding a factor of two were observed near θ=150° and in contact with the source, but diminished to within 20% at r=10 cm. Conclusions: Changes in source design influenced the overall dose rate and distribution by more than 2% over a third of the available solid angle external from the source. For clinical applications using balloons or applicators with tissue located within 5 cm from the source, dose differences exceeding 2% were observed only for θ>110°. This study carefully examined the current source geometry and presents a modern reference TG-43 dosimetry dataset for the model S700 source.« less

Adaptive trial designs: a review of barriers and opportunities

PubMed Central

2012-01-01

Adaptive designs allow planned modifications based on data accumulating within a study. The promise of greater flexibility and efficiency stimulates increasing interest in adaptive designs from clinical, academic, and regulatory parties. When adaptive designs are used properly, efficiencies can include a smaller sample size, a more efficient treatment development process, and an increased chance of correctly answering the clinical question of interest. However, improper adaptations can lead to biased studies. A broad definition of adaptive designs allows for countless variations, which creates confusion as to the statistical validity and practical feasibility of many designs. Determining properties of a particular adaptive design requires careful consideration of the scientific context and statistical assumptions. We first review several adaptive designs that garner the most current interest. We focus on the design principles and research issues that lead to particular designs being appealing or unappealing in particular applications. We separately discuss exploratory and confirmatory stage designs in order to account for the differences in regulatory concerns. We include adaptive seamless designs, which combine stages in a unified approach. We also highlight a number of applied areas, such as comparative effectiveness research, that would benefit from the use of adaptive designs. Finally, we describe a number of current barriers and provide initial suggestions for overcoming them in order to promote wider use of appropriate adaptive designs. Given the breadth of the coverage all mathematical and most implementation details are omitted for the sake of brevity. However, the interested reader will find that we provide current references to focused reviews and original theoretical sources which lead to details of the current state of the art in theory and practice. PMID:22917111

SRM-Assisted Trajectory for the GTX Reference Vehicle

NASA Technical Reports Server (NTRS)

Riehl, John; Trefny, Charles; Kosareo, Daniel

2002-01-01

A goal of the GTX effort has been to demonstrate the feasibility of a single stage- to- orbit (SSTO) vehicle that delivers a small payload to low earth orbit. The small payload class was chosen in order to minimize the risk and cost of development of this revolutionary system. A preliminary design study by the GTX team has resulted in the current configuration that offers considerable promise for meeting the stated goal. The size and gross lift-off weight resulting from scaling the current design to closure however may be considered impractical for the small payload. In lieu of evolving the project's reference vehicle to a large-payload class, this paper offers the alternative of using solid-rocket motors in order to close the vehicle at a practical scale. This approach offers a near-term, quasi-reusable system that easily evolves to reusable SSTO following subsequent development and optimization. This paper presents an overview of the impact of the addition of SRM's to the GTX reference vehicle's performance and trajectory. The overall methods of vehicle modeling and trajectory optimization will also be presented. A key element in the trajectory optimization is the use of the program OTIS 3.10 that provides rapid convergence and a great deal of flexibility to the user. This paper will also present the methods used to implement GTX requirements into OTIS modeling.

SRM-Assisted Trajectory for the GTX Reference Vehicle

NASA Technical Reports Server (NTRS)

Riehl, John; Trefny, Charles; Kosareo, Daniel (Technical Monitor)

2002-01-01

A goal of the GTX effort has been to demonstrate the feasibility of a single stage-to-orbit (SSTO) vehicle that delivers a small payload to low earth orbit. The small payload class was chosen in order to minimize the risk and cost of development of this revolutionary system. A preliminary design study by the GTX team has resulted in the current configuration that offers considerable promise for meeting the stated goal. The size and gross lift-off weight resulting from scaling the current design to closure however may be considered impractical for the small payload. In lieu of evolving the project' reference vehicle to a large-payload class, this paper offers the alternative of using solid-rocket motors in order to close the vehicle at a practical scale. This approach offers a near-term, quasi-reusable system that easily evolves to reusable SSTO following subsequent development and optimization. This paper presents an overview of the impact of the addition of SRM's to the GTX reference vehicle#s performance and trajectory. The overall methods of vehicle modeling and trajectory optimization will also be presented. A key element in the trajectory optimization is the use of the program OTIS 3.10 that provides rapid convergence and a great deal of flexibility to the user. This paper will also present the methods used to implement GTX requirements into OTIS modeling.

Antares Reference Telescopes System

NASA Astrophysics Data System (ADS)

Viswanathan, V. K.; Kaprelian, E.; Swann, T.; Parker, J.; Wolfe, P.; Woodfin, G.; Knight, D.

1983-11-01

Antares is a 24-beam, 40-TW carbon-dioxide laser fusion system currently nearing completion at the Los Alamos National Laboratory. The 24 beams will be focused onto a tiny target (typically 300-1000 pm in diameter) located approximately at the center of a 7.3-m diameter by 9.3-m long vacuum (10-6 torr) chamber. The design goal is to position the targets to within 10 μm of a selected nominal position, which may be anywhere within a fixed spherical region 1 cm in diameter. The Antares Reference Telescope System is intended to help achieve this goal for alignment and viewing of the various targets used in the laser system. The Antares Reference Telescope System consists of two similar electro-optical systems positioned in a near orthogonal manner in the target chamber area of the laser. Each of these consists of four subsystems: 1) a fixed 9X optical imaging subsystem which produces an image of the target at the vidicon; 2) a reticle projection subsystem which superimposes an image of the reticle pattern at the vidicon; 3) an adjustable front-lighting subsystem which illuminates tne target; and 4) an adjustable back-lighting subsystem which also can be used to illuminate the target. The various optical, mechanical, and vidicon design considerations and trade-offs are discussed. The final system chosen (which is being built) and its current status are described in detail.

Fuel characteristics pertinent to the design of aircraft fuel systems

NASA Technical Reports Server (NTRS)

Barnett, Henry C; Hibbard, R R

1953-01-01

Because of the importance of fuel properties in design of aircraft fuel systems the present report has been prepared to provide information on the characteristics of current jet fuels. In addition to information on fuel properties, discussions are presented on fuel specifications, the variations among fuels supplied under a given specification, fuel composition, and the pertinence of fuel composition and physical properties to fuel system design. In some instances the influence of variables such as pressure and temperature on physical properties is indicated. References are cited to provide fuel system designers with sources of information containing more detail than is practicable in the present report.

An Integrated RFID and Barcode Tagged Item Inventory System for Deployment at New Brunswick Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Younkin, James R; Kuhn, Michael J; Gradle, Colleen

New Brunswick Laboratory (NBL) has a numerous inventory containing thousands of plutonium and uranium certified reference materials. The current manual inventory process is well established but is a lengthy process which requires significant oversight and double checking to ensure correctness. Oak Ridge National Laboratory has worked with NBL to develop and deploy a new inventory system which utilizes handheld computers with barcode scanners and radio frequency identification (RFID) readers termed the Tagged Item Inventory System (TIIS). Certified reference materials are identified by labels which incorporate RFID tags and barcodes. The label printing process and RFID tag association process are integratedmore » into the main desktop software application. Software on the handheld computers syncs with software on designated desktop machines and the NBL inventory database to provide a seamless inventory process. This process includes: 1) identifying items to be inventoried, 2) downloading the current inventory information to the handheld computer, 3) using the handheld to read item and location labels, and 4) syncing the handheld computer with a designated desktop machine to analyze the results, print reports, etc. The security of this inventory software has been a major concern. Designated roles linked to authenticated logins are used to control access to the desktop software while password protection and badge verification are used to control access to the handheld computers. The overall system design and deployment at NBL will be presented. The performance of the system will also be discussed with respect to a small piece of the overall inventory. Future work includes performing a full inventory at NBL with the Tagged Item Inventory System and comparing performance, cost, and radiation exposures to the current manual inventory process.« less

Creating an Electronic Reference and Information Database for Computer-aided ECM Design

NASA Astrophysics Data System (ADS)

Nekhoroshev, M. V.; Pronichev, N. D.; Smirnov, G. V.

2018-01-01

The paper presents a review on electrochemical shaping. An algorithm has been developed to implement a computer shaping model applicable to pulse electrochemical machining. For that purpose, the characteristics of pulse current occurring in electrochemical machining of aviation materials have been studied. Based on integrating the experimental results and comprehensive electrochemical machining process data modeling, a subsystem for computer-aided design of electrochemical machining for gas turbine engine blades has been developed; the subsystem was implemented in the Teamcenter PLM system.

Digital-computer program for design analysis of salient, wound pole alternators

NASA Technical Reports Server (NTRS)

Repas, D. S.

1973-01-01

A digital computer program for analyzing the electromagnetic design of salient, wound pole alternators is presented. The program, which is written in FORTRAN 4, calculates the open-circuit saturation curve, the field-current requirements at rated voltage for various loads and losses, efficiency, reactances, time constants, and weights. The methods used to calculate some of these items are presented or appropriate references are cited. Instructions for using the program and typical program input and output for an alternator design are given, and an alphabetical list of most FORTRAN symbols and the complete program listing with flow charts are included.

Does a Gatekeeper Suicide Prevention Program Work in a School Setting? Evaluating Training Outcome and Moderators of Effectiveness

ERIC Educational Resources Information Center

Tompkins, Tanya L.; Witt, Jody; Abraibesh, Nadia

2009-01-01

The current study sought to evaluate the suicide prevention gatekeeper training program QPR (Question, Persuade, and Refer) among school personnel using a non-equivalent control group design. Substantial gains were demonstrated from pre- to post-test for attitudes, knowledge, and beliefs regarding suicide and suicide prevention. Exploratory…

Enhancing Foreign Language Learning through Listening Strategies Delivered in L1: An Experimental Study

ERIC Educational Resources Information Center

Bozorgian, Hossein; Pillay, Hitendra

2013-01-01

Listening used in language teaching refers to a complex process that allows us to understand spoken language. The current study, conducted in Iran with an experimental design, investigated the effectiveness of teaching listening strategies delivered in L1 (Persian) and its effect on listening comprehension in L2. Five listening strategies:…

A Low-Noise Transimpedance Amplifier for BLM-Based Ion Channel Recording.

PubMed

Crescentini, Marco; Bennati, Marco; Saha, Shimul Chandra; Ivica, Josip; de Planque, Maurits; Morgan, Hywel; Tartagni, Marco

2016-05-19

High-throughput screening (HTS) using ion channel recording is a powerful drug discovery technique in pharmacology. Ion channel recording with planar bilayer lipid membranes (BLM) is scalable and has very high sensitivity. A HTS system based on BLM ion channel recording faces three main challenges: (i) design of scalable microfluidic devices; (ii) design of compact ultra-low-noise transimpedance amplifiers able to detect currents in the pA range with bandwidth >10 kHz; (iii) design of compact, robust and scalable systems that integrate these two elements. This paper presents a low-noise transimpedance amplifier with integrated A/D conversion realized in CMOS 0.35 μm technology. The CMOS amplifier acquires currents in the range ±200 pA and ±20 nA, with 100 kHz bandwidth while dissipating 41 mW. An integrated digital offset compensation loop balances any voltage offsets from Ag/AgCl electrodes. The measured open-input input-referred noise current is as low as 4 fA/√Hz at ±200 pA range. The current amplifier is embedded in an integrated platform, together with a microfluidic device, for current recording from ion channels. Gramicidin-A, α-haemolysin and KcsA potassium channels have been used to prove both the platform and the current-to-digital converter.

A Low-Noise Transimpedance Amplifier for BLM-Based Ion Channel Recording

PubMed Central

Crescentini, Marco; Bennati, Marco; Saha, Shimul Chandra; Ivica, Josip; de Planque, Maurits; Morgan, Hywel; Tartagni, Marco

2016-01-01

High-throughput screening (HTS) using ion channel recording is a powerful drug discovery technique in pharmacology. Ion channel recording with planar bilayer lipid membranes (BLM) is scalable and has very high sensitivity. A HTS system based on BLM ion channel recording faces three main challenges: (i) design of scalable microfluidic devices; (ii) design of compact ultra-low-noise transimpedance amplifiers able to detect currents in the pA range with bandwidth >10 kHz; (iii) design of compact, robust and scalable systems that integrate these two elements. This paper presents a low-noise transimpedance amplifier with integrated A/D conversion realized in CMOS 0.35 μm technology. The CMOS amplifier acquires currents in the range ±200 pA and ±20 nA, with 100 kHz bandwidth while dissipating 41 mW. An integrated digital offset compensation loop balances any voltage offsets from Ag/AgCl electrodes. The measured open-input input-referred noise current is as low as 4 fA/√Hz at ±200 pA range. The current amplifier is embedded in an integrated platform, together with a microfluidic device, for current recording from ion channels. Gramicidin-A, α-haemolysin and KcsA potassium channels have been used to prove both the platform and the current-to-digital converter. PMID:27213382

Development of a self-managed loaded exercise programme for rotator cuff tendinopathy.

PubMed

Littlewood, Chris; Malliaras, Peter; Mawson, Sue; May, Stephen; Walters, Stephen

2013-12-01

This paper describes a self-managed loaded exercise programme which has been designed to address the pain and disability associated with rotator cuff tendinopathy. The intervention has been developed with reference to current self-management theory and with reference to the emerging benefit of loaded exercise for tendinopathy. This self-managed loaded exercise programme is being evaluated within the mixed methods SELF study (ISRCTN 84709751) which includes a pragmatic randomised controlled trial conducted within the UK National Health Service. Copyright © 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

A CMOS power-efficient low-noise current-mode front-end amplifier for neural signal recording.

PubMed

Wu, Chung-Yu; Chen, Wei-Ming; Kuo, Liang-Ting

2013-04-01

In this paper, a new current-mode front-end amplifier (CMFEA) for neural signal recording systems is proposed. In the proposed CMFEA, a current-mode preamplifier with an active feedback loop operated at very low frequency is designed as the first gain stage to bypass any dc offset current generated by the electrode-tissue interface and to achieve a low high-pass cutoff frequency below 0.5 Hz. No reset signal or ultra-large pseudo resistor is required. The current-mode preamplifier has low dc operation current to enhance low-noise performance and decrease power consumption. A programmable current gain stage is adopted to provide adjustable gain for adaptive signal scaling. A following current-mode filter is designed to adjust the low-pass cutoff frequency for different neural signals. The proposed CMFEA is designed and fabricated in 0.18-μm CMOS technology and the area of the core circuit is 0.076 mm(2). The measured high-pass cutoff frequency is as low as 0.3 Hz and the low-pass cutoff frequency is adjustable from 1 kHz to 10 kHz. The measured maximum current gain is 55.9 dB. The measured input-referred current noise density is 153 fA /√Hz , and the power consumption is 13 μW at 1-V power supply. The fabricated CMFEA has been successfully applied to the animal test for recording the seizure ECoG of Long-Evan rats.

The search for a 100MA RancheroS magnetic flux compression generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watt, Robert Gregory

2016-09-01

The Eulerian AMR rad-hydro-MHD code Roxane was used to investigate modifications to existing designs of the new RancheroS class of Magnetic Flux Compression Generators (FCGs) which might allow some members of this FCG family to exceed 100 MA driving a 10 nH static load. This report details the results of that study and proposes a specific generator modification which seems to satisfy both the peak current and desired risetime for the current pulse into the load. The details of the study and necessary modifications are presented. For details of the LA43S RancheroS FCG design and predictions for the first usemore » of the generator refer to the relevant publications.« less

GPS antenna designs

NASA Technical Reports Server (NTRS)

Laube, Samuel J. P.

1987-01-01

Application of the current GPS NAVSTAR system to civilian service requires that a right hand, circularly polarized, -160 dBW spread spectrum signal be received from an orbiting satellite, where the antenna environment is also moving. This presents a design challenge when inexpensive antennas are desired. The intent of this survey is to provide information on the antennas mentioned and to construct and test prototypes to determine whether the choice made by the industry, the quadrifilar helix, is the best. The helix antenna is currently the low cost standard for GPS. Prototype versions were constructed using 12 gauge wire and subminiature coaxial hardline. The constructed antennas were tested using a signal generator and a reference turnstile. A spectrum analyzer was used to measure the level of the received signal.

Improved method for selection of the NOAEL.

PubMed

Calabrese, E J; Baldwin, L A

1994-02-01

The paper proposes that the NOAEL be defined as the highest dosage tested that is statistically significantly different from the control group while also being statistically significantly different from the LOAEL. This new definition requires that the NOAEL be defined from two points of reference rather than the current approach (i.e., single point of reference) in which the NOAEL represents only the highest dosage not statistically significantly different from the control group. This proposal is necessary in order to differentiate NOAELs which are statistically distinguishable from the LOAEL. Under the new regime only those satisfying both criteria would be designated a true NOAEL while those satisfying only one criteria (i.e., not statistically significant different from the control group) would be designated a "quasi" NOAEL and handled differently (i.e., via an uncertainty factor) for risk assessment purposes.

Adjoint-Based Design of Rotors Using the Navier-Stokes Equations in a Noninertial Reference Frame

NASA Technical Reports Server (NTRS)

Nielsen, Eric J.; Lee-Rausch, Elizabeth M.; Jones, William T.

2010-01-01

Optimization of rotorcraft flowfields using an adjoint method generally requires a time-dependent implementation of the equations. The current study examines an intermediate approach in which a subset of rotor flowfields are cast as steady problems in a noninertial reference frame. This technique permits the use of an existing steady-state adjoint formulation with minor modifications to perform sensitivity analyses. The formulation is valid for isolated rigid rotors in hover or where the freestream velocity is aligned with the axis of rotation. Discrete consistency of the implementation is demonstrated by using comparisons with a complex-variable technique, and a number of single- and multipoint optimizations for the rotorcraft figure of merit function are shown for varying blade collective angles. Design trends are shown to remain consistent as the grid is refined.

Adjoint-Based Design of Rotors using the Navier-Stokes Equations in a Noninertial Reference Frame

NASA Technical Reports Server (NTRS)

Nielsen, Eric J.; Lee-Rausch, Elizabeth M.; Jones, William T.

2009-01-01

Optimization of rotorcraft flowfields using an adjoint method generally requires a time-dependent implementation of the equations. The current study examines an intermediate approach in which a subset of rotor flowfields are cast as steady problems in a noninertial reference frame. This technique permits the use of an existing steady-state adjoint formulation with minor modifications to perform sensitivity analyses. The formulation is valid for isolated rigid rotors in hover or where the freestream velocity is aligned with the axis of rotation. Discrete consistency of the implementation is demonstrated using comparisons with a complex-variable technique, and a number of single- and multi-point optimizations for the rotorcraft figure of merit function are shown for varying blade collective angles. Design trends are shown to remain consistent as the grid is refined.

Energy efficient engine: Flight propulsion system preliminary analysis and design

NASA Technical Reports Server (NTRS)

Johnston, R. P.; Beitler, R. S.; Bobinger, R. O.; Broman, C. L.; Gravitt, R. D.; Heineke, H.; Holloway, P. R.; Klem, J. S.; Nash, D. O.; Ortiz, P.

1980-01-01

The characteristics of an advanced flight propulsion system (FPS), suitable for introduction in the late 1980's to early 1990's, was more fully defined. It was determined that all goals for efficiency, environmental considerations, and economics could be met or exceeded with the possible exception of NOx emission. In evaluating the FPS, all aspects were considered including component design, performance, weight, initial cost, maintenance cost, engine system integration (including nacelle), and aircraft integration considerations. The current FPS installed specific fuel consumption was reduced 14.2% from that of the CF6-50C reference engine. When integrated into an advanced, subsonic, study transport, the FPS produced a fuel burn savings of 15 to 23% and a direct operating cost reduction of 5 to 12% depending on the mission and study aircraft characteristics relative to the reference engine.

Stirling engine design manual

NASA Technical Reports Server (NTRS)

Martini, W. R.

1978-01-01

This manual is intended to serve both as an introduction to Stirling engine analysis methods and as a key to the open literature on Stirling engines. Over 800 references are listed and these are cross referenced by date of publication, author and subject. Engine analysis is treated starting from elementary principles and working through cycles analysis. Analysis methodologies are classified as first, second or third order depending upon degree of complexity and probable application; first order for preliminary engine studies, second order for performance prediction and engine optimization, and third order for detailed hardware evaluation and engine research. A few comparisons between theory and experiment are made. A second order design procedure is documented step by step with calculation sheets and a worked out example to follow. Current high power engines are briefly described and a directory of companies and individuals who are active in Stirling engine development is included. Much remains to be done. Some of the more complicated and potentially very useful design procedures are now only referred to. Future support will enable a more thorough job of comparing all available design procedures against experimental data which should soon be available.

Monte Carlo Simulations Comparing the Response of a Novel Hemispherical Tepc to Existing Spherical and Cylindrical Tepcs for Neutron Monitoring and Dosimetry.

PubMed

Broughton, David P; Waker, Anthony J

2017-05-01

Neutron dosimetry in reactor fields is currently mainly conducted with unwieldy flux monitors. Tissue Equivalent Proportional Counters (TEPCs) have been shown to have the potential to improve the accuracy of neutron dosimetry in these fields, and Multi-Element Tissue Equivalent Proportional Counters (METEPCs) could reduce the size of instrumentation required to do so. Complexity of current METEPC designs has inhibited their use beyond research. This work proposes a novel hemispherical counter with a wireless anode ball in place of the traditional anode wire as a possible solution for simplifying manufacturing. The hemispherical METEPC element was analyzed as a single TEPC to first demonstrate the potential of this new design by evaluating its performance relative to the reference spherical TEPC design and a single element from a cylindrical METEPC. Energy deposition simulations were conducted using the Monte Carlo code PHITS for both monoenergetic 2.5 MeV neutrons and the neutron energy spectrum of Cf-D2O moderated. In these neutron fields, the hemispherical counter appears to be a good alternative to the reference spherical geometry, performing slightly better than the cylindrical counter, which tends to underrespond to H*(10) for the lower neutron energies of the Cf-D2O moderated field. These computational results are promising, and if follow-up experimental work demonstrates the hemispherical counter works as anticipated, it will be ready to be incorporated into an METEPC design.

Coordinate interferometric system for measuring the position of a sample with infrared telecom laser diode

NASA Astrophysics Data System (ADS)

Holá, Miroslava; Lazar, Josef; Čížek, Martin; Hucl, Václav; Řeřucha, Šimon; Číp, Ondřej

2016-11-01

We report on a design of an interferometric position measuring system for control of a sample stage in an e-beam writer with reproducibility of the position on nanometer level and resolution below nanometer. We introduced differential configuration of the interferometer where the position is measured with respect to a central reference point to eliminate deformations caused by thermal and pressure effects on the vacuum chamber. The reference is here the electron gun of the writer. The interferometer is designed to operate at infrared, telecommunication wavelength due to the risk of interference of stray light with sensitive photodetectors in the chamber. The laser source is here a narrow-linewidth DFB laser diode with electronics of our own design offering precision and stability of temperature and current, low-noise, protection from rf interference, and high-frequency modulation. Detection of the interferometric signal relies on a novel derivative technique utilizing hf frequency modulation and phase-sensitive detection.

A review of accuracy assessment for object-based image analysis: From per-pixel to per-polygon approaches

NASA Astrophysics Data System (ADS)

Ye, Su; Pontius, Robert Gilmore; Rakshit, Rahul

2018-07-01

Object-based image analysis (OBIA) has gained widespread popularity for creating maps from remotely sensed data. Researchers routinely claim that OBIA procedures outperform pixel-based procedures; however, it is not immediately obvious how to evaluate the degree to which an OBIA map compares to reference information in a manner that accounts for the fact that the OBIA map consists of objects that vary in size and shape. Our study reviews 209 journal articles concerning OBIA published between 2003 and 2017. We focus on the three stages of accuracy assessment: (1) sampling design, (2) response design and (3) accuracy analysis. First, we report the literature's overall characteristics concerning OBIA accuracy assessment. Simple random sampling was the most used method among probability sampling strategies, slightly more than stratified sampling. Office interpreted remotely sensed data was the dominant reference source. The literature reported accuracies ranging from 42% to 96%, with an average of 85%. A third of the articles failed to give sufficient information concerning accuracy methodology such as sampling scheme and sample size. We found few studies that focused specifically on the accuracy of the segmentation. Second, we identify a recent increase of OBIA articles in using per-polygon approaches compared to per-pixel approaches for accuracy assessment. We clarify the impacts of the per-pixel versus the per-polygon approaches respectively on sampling, response design and accuracy analysis. Our review defines the technical and methodological needs in the current per-polygon approaches, such as polygon-based sampling, analysis of mixed polygons, matching of mapped with reference polygons and assessment of segmentation accuracy. Our review summarizes and discusses the current issues in object-based accuracy assessment to provide guidance for improved accuracy assessments for OBIA.

Launch Vehicle Design and Optimization Methods and Priority for the Advanced Engineering Environment

NASA Technical Reports Server (NTRS)

Rowell, Lawrence F.; Korte, John J.

2003-01-01

NASA's Advanced Engineering Environment (AEE) is a research and development program that will improve collaboration among design engineers for launch vehicle conceptual design and provide the infrastructure (methods and framework) necessary to enable that environment. In this paper, three major technical challenges facing the AEE program are identified, and three specific design problems are selected to demonstrate how advanced methods can improve current design activities. References are made to studies that demonstrate these design problems and methods, and these studies will provide the detailed information and check cases to support incorporation of these methods into the AEE. This paper provides background and terminology for discussing the launch vehicle conceptual design problem so that the diverse AEE user community can participate in prioritizing the AEE development effort.

The NISTmAb Reference Material 8671 lifecycle management and quality plan.

PubMed

Schiel, John E; Turner, Abigail

2018-03-01

Comprehensive analysis of monoclonal antibody therapeutics involves an ever expanding cadre of technologies. Lifecycle-appropriate application of current and emerging techniques requires rigorous testing followed by discussion between industry and regulators in a pre-competitive space, an effort that may be facilitated by a widely available test metric. Biopharmaceutical quality materials, however, are often difficult to access and/or are protected by intellectual property rights. The NISTmAb, humanized IgG1κ Reference Material 8671 (RM 8671), has been established with the intent of filling that void. The NISTmAb embodies the quality and characteristics of a typical biopharmaceutical product, is widely available to the biopharmaceutical community, and is an open innovation tool for development and dissemination of results. The NISTmAb lifecyle management plan described herein provides a hierarchical strategy for maintenance of quality over time through rigorous method qualification detailed in additional submissions in the current publication series. The NISTmAb RM 8671 is a representative monoclonal antibody material and provides a means to continually evaluate current best practices, promote innovative approaches, and inform regulatory paradigms as technology advances. Graphical abstract The NISTmAb Reference Material (RM) 8671 is intended to be an industry standard monoclonal antibody for pre-competitive harmonization of best practices and designing next generation characterization technologies for identity, quality, and stability testing.

Determination of Galactic Aberration from VLBI Measurements and Its Effect on VLBI Reference Frames and Earth Orientation Parameters.

NASA Astrophysics Data System (ADS)

MacMillan, D. S.

2014-12-01

Galactic aberration is due to the motion of the solar system barycenter around the galactic center. It results in a systematic pattern of apparent proper motion of radio sources observed by VLBI. This effect is not currently included in VLBI analysis. Estimates of the size of this effect indicate that it is important that this secular aberration drift be accounted for in order to maintain an accurate celestial reference frame and allow astrometry at the several microarcsecond level. Future geodetic observing systems are being designed to be capable of producing a future terrestrial reference frame with an accuracy of 1 mm and stability of 0.1 mm/year. We evaluate the effect galactic aberration on attaining these reference frame goals. This presentation will discuss 1) the estimation of galactic aberration from VLBI data and 2) the effect of aberration on the Terrestrial and Celestial Reference Frames and the Earth Orientation Parameters that connect these frames.

Antares reference telescope system

NASA Astrophysics Data System (ADS)

Viswanathan, V. K.; Kaprelian, E.; Swann, T.; Parker, J.; Wolfe, P.; Woodfin, G.; Knight, D.

Antares is a 24 beam, 40 TW carbon dioxide laser fusion system currently nearing completion. The 24 beams will be focused onto a tiny target. It is to position the targets to within 10 (SIGMA)m of a selected nominal position, which may be anywhere within a fixed spherical region 1 cm in diameter. The Antares reference telescope system is intended to help achieve this goal for alignment and viewing of the various targets used in the laser system. The Antares reference telescope system consists of two similar electrooptical systems positioned in a near orthogonal manner in the target chamber area of the laser. Each of these consists of four subsystems: (1) a fixed 9% optical imaging subsystem which produces an image of the target at the vidicon; (2) a reticle projection subsystem which superimposes an image of the reticle pattern at the vidicon; (3) an adjustable front lighting subsystem which illuminates the target; and (4) an adjustable back lighting subsystem which also can be used to illuminate the target. The various optical, mechanical, and vidicon design considerations and tradeoffs are discussed. The final system chosen and its current status are described.

Conception preliminaire de disques de turbine axiale pour moteurs d'aeronefs

NASA Astrophysics Data System (ADS)

Ouellet, Yannick

The preliminary design phase of a turbine rotor has an important impact on the architecture of a new engine definition, as it sets the technical orientation right from start and provides a good estimate of product performance, weight and cost. In addition, the execution speed at this preliminary phase has become critical into capturing business opportunities. Improving upfront accuracy also alleviates downstream detailed design work and therefore reduces overall product development cycle time. This preliminary phase contains elements slowing down its process, including low interoperability of currently used systems, incompatibility of software and ineffective management of data. In order to overcome these barriers, we have developed the first module of a new Design and Analysis (D&A) platform for the rotor disc. This complete platform ensures integration of different tools processing in batch mode, and is driven from a single graphical user interface. The platform developed has been linked with different optimization methods (algorithms, configuration) in order to automate the disc design and propose best practices for rotor structural optimization. This methodology allowed reduction in design cycle time and improvement of performance. It was applied on two reference P&WC axial discs. The platform's architecture was also used in the development of reference charts to better understand disc performance within given design space. Four high pressure rotor discs of P&WC turbofan and turboprop engines were used to generate the technical charts and understand the effect of various parameters. The new tools supporting disc D&A, combined with the optimization process and reference charts, has proven to be profitable in terms of component performance and engineering effort inputs.

Establishing a Modern Ground Network for Space Geodesy Applications

NASA Technical Reports Server (NTRS)

Pearlman, M.; Pavlis, E.; Altamimi, Z.; Noll, C.

2010-01-01

Ground-based networks of co-located space-geodesy techniques (VLBI, SLR, GLASS, DORIS) are the basis for the development and maintenance of the :International Terrestrial deference Frame (ITRE), which is the basis for our metric measurements of global change. The Global Geodetic Observing System (GGOS) within the International Association of Geodesy has established a task to develop a strategy to design, integrate and maintain the fundamental geodetic network and supporting infrastructure in a sustainable way to satisfy the long-term requirements for the reference frame. The GGOS goal is an origin definition at I mm or better and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale and orientation components. These goals are based on scientific requirements to address sea level rise with confidence. As a first step, simulations focused on establishing the optimal global SLR and VLBI network, since these two techniques alone are sufficient to define the reference frame. The GLASS constellations will then distribute the reference frame to users anywhere on the Earth. Using simulated data to be collected by the future networks, we investigated various designs and the resulting accuracy in the origin, scale and orientation of the resulting ITRF. We present here the results of extensive simulation studies aimed at designing optimal global geodetic networks to support GGOS science products. Current estimates are the network will require 24 - 32 globally distributed co-location sites. Stations in the near global network will require geologically stable sites witla good weather, established infrastructure, and local support and personnel. EGOS will seek groups that are interested in participation. GGOS intends to issues a Call for Participation of groups that would like to take part in the network implementation and operation_ Some examples of integrated stations currently in operation or under development will be presented. We will examine necessary conditions and challenges in designing a co-location station.

Applicability of Aerospace Materials Ground Flammability Test Data to Spacecraft Environments Theory and Applied Technologies

NASA Technical Reports Server (NTRS)

Hirsch, David; Williams, Jim; Beeson, Harold

2009-01-01

This slide presentation reviews the use of ground test data in reference to flammability to spacecraft environments. It reviews the current approach to spacecraft fire safety, the challenges to fire safety that the Constellation program poses, the current trends in the evaluation of the Constellation materials flammability, and the correlation of test data from ground flammability tests with the spacecraft environment. Included is a proposal for testing and the design of experiments to test the flammability of materials under similar spacecraft conditions.

Battery Cell By-Pass Circuit

NASA Technical Reports Server (NTRS)

Mumaw, Susan J. (Inventor); Evers, Jeffrey (Inventor); Craig, Calvin L., Jr. (Inventor); Walker, Stuart D. (Inventor)

2001-01-01

The invention is a circuit and method of limiting the charging current voltage from a power supply net work applied to an individual cell of a plurality of cells making up a battery being charged in series. It is particularly designed for use with batteries that can be damaged by overcharging, such as Lithium-ion type batteries. In detail. the method includes the following steps: 1) sensing the actual voltage level of the individual cell; 2) comparing the actual voltage level of the individual cell with a reference value and providing an error signal representative thereof; and 3) by-passing the charging current around individual cell necessary to keep the individual cell voltage level generally equal a specific voltage level while continuing to charge the remaining cells. Preferably this is accomplished by by-passing the charging current around the individual cell if said actual voltage level is above the specific voltage level and allowing the charging current to the individual cell if the actual voltage level is equal or less than the specific voltage level. In the step of bypassing the charging current, the by-passed current is transferred at a proper voltage level to the power supply. The by-pass circuit a voltage comparison circuit is used to compare the actual voltage level of the individual cell with a reference value and to provide an error signal representative thereof. A third circuit, designed to be responsive to the error signal, is provided for maintaining the individual cell voltage level generally equal to the specific voltage level. Circuitry is provided in the third circuit for bypassing charging current around the individual cell if the actual voltage level is above the specific voltage level and transfers the excess charging current to the power supply net work. The circuitry also allows charging of the individual cell if the actual voltage level is equal or less than the specific voltage level.

Best practices for hybridization design in two-colour microarray analysis.

PubMed

Knapen, Dries; Vergauwen, Lucia; Laukens, Kris; Blust, Ronny

2009-07-01

Two-colour microarrays are a popular platform of choice in gene expression studies. Because two different samples are hybridized on a single microarray, and several microarrays are usually needed in a given experiment, there are many possible ways to combine samples on different microarrays. The actual combination employed is commonly referred to as the 'hybridization design'. Different types of hybridization designs have been developed, all aimed at optimizing the experimental setup for the detection of differentially expressed genes while coping with technical noise. Here, we first provide an overview of the different classes of hybridization designs, discussing their advantages and limitations, and then we illustrate the current trends in the use of different hybridization design types in contemporary research.

[Current situation and issues for analyzing illegal drug products].

PubMed

Hasegawa, Takashi; Takahashi, Kazunaga; Saijo, Masaaki; Fukiwake, Tomohide; Motoki, Yuji

2013-01-01

Thirty-two psychotropic substances (31 compounds and one plant) have been controlled as designated substances (Shitei-yakubutsu) in Japan by the Pharmaceutical Affairs Law since April 2007. Although the trafficking of these drugs has decreased because of this regulation, new designer drugs (synthetic cannabinoids and cathinones) have appeared, one after the other. As of October 2011, 40 compounds had been newly added to this category. Analytical methods have become more complicated due to this increase in the number of designated substances. Moreover, many reference substances for such designated substances and other new designer drugs are not commercially available. For the reasons stated above, a lot of time and effort is required to analyze the illegal drug products available on the market.

Alternative Assessment in Engineering Language Education: The Case of the Technical University of Madrid

ERIC Educational Resources Information Center

Pierce, Joana; Duran, Pilar; Ubeda, Paloma

2011-01-01

Engineering institutions across Europe are currently involved in a major process of reform and restructuring as a part of the Bologna Process, which stresses the role of competencies and outcomes in curriculum design. In the field of languages, the Council of Europe has developed the CEFR (Common European Framework of References) for languages,…

Historical disturbance regimes as a reference for forest policy. in a multiowner province: a simulation experiment

Treesearch

Jonathan R. Thompson; K. Norman Johnson; Marie Lennette; Thomas A. Spies; Pete Bettinger

2006-01-01

Using a landscape simulation model, we examined ecological and economic implications of forest policies designed to emulate the historical fire regime across the 2 x 106 ha Oregon Coast Range. Simulated policies included two variants of the current policy and three policies reflecting aspects of the historical fire regime. Policy development was...

Transformed Telepresence and Its Association with Learning in Computer-Supported Collaborative Learning: A Case Study in English Learning and Its Evaluation

ERIC Educational Resources Information Center

Ting, Yu-Liang; Tai, Yaming; Chen, Jun-Horng

2017-01-01

Telepresence has been playing an important role in a mediated learning environment. However, the current design of telepresence seems to be dominated by the emulation of physical human presence. With reference to social constructivism learning and the recognition of individuals as intelligent entities, this study explored the transformation of…

Onboard guidance system design for reusable launch vehicles in the terminal area energy management phase

NASA Astrophysics Data System (ADS)

Mu, Lingxia; Yu, Xiang; Zhang, Y. M.; Li, Ping; Wang, Xinmin

2018-02-01

A terminal area energy management (TAEM) guidance system for an unpowered reusable launch vehicle (RLV) is proposed in this paper. The mathematical model representing the RLV gliding motion is provided, followed by a transformation of extracting the required dynamics for reference profile generation. Reference longitudinal profiles are conceived based on the capability of maximum dive and maximum glide that a RLV can perform. The trajectory is obtained by iterating the motion equations at each node of altitude, where the angle of attack and the flight-path angle are regarded as regulating variables. An onboard ground-track predictor is constructed to generate the current range-to-go and lateral commands online. Although the longitudinal profile generation requires pre-processing using the RLV aerodynamics, the ground-track prediction can be executed online. This makes the guidance scheme adaptable to abnormal conditions. Finally, the guidance law is designed to track the reference commands. Numerical simulations demonstrate that the proposed guidance scheme is capable of guiding the RLV to the desired touchdown conditions.

Application Research of Horn Array Multi-Beam Antenna in Reference Source System for Satellite Interference Location

NASA Astrophysics Data System (ADS)

Zhou, Ping; Lin, Hui; Zhang, Qi

2018-01-01

The reference source system is a key factor to ensure the successful location of the satellite interference source. Currently, the traditional system used a mechanical rotating antenna which leaded to the disadvantages of slow rotation and high failure-rate, which seriously restricted the system’s positioning-timeliness and became its obvious weaknesses. In this paper, a multi-beam antenna scheme based on the horn array was proposed as a reference source for the satellite interference location, which was used as an alternative to the traditional reference source antenna. The new scheme has designed a small circularly polarized horn antenna as an element and proposed a multi-beamforming algorithm based on planar array. Moreover, the simulation analysis of horn antenna pattern, multi-beam forming algorithm and simulated satellite link cross-ambiguity calculation have been carried out respectively. Finally, cross-ambiguity calculation of the traditional reference source system has also been tested. The comparison between the results of computer simulation and the actual test results shows that the scheme is scientific and feasible, obviously superior to the traditional reference source system.

Human Exploration of Mars Design Reference Architecture 5.0

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2009-01-01

This document reviews the Design Reference Architecture (DRA) for human exploration of Mars. The DRA represents the current best strategy for human missions. The DRA is not a formal plan, but provides a vision and context to tie current systems and technology developments to potential missions to Mars, and it also serves as a benchmark against which alternative architectures can be measured. The document also reviews the objectives and products of the 2007 study that was to update NASA's human Mars mission reference architecture, assess strategic linkages between lunar and Mars strategies, develop an understanding of methods for reducing cost/risk of human missions through investment in research, technology development and synergy with other exploration plans. There is also a review of the process by which the DRA will continue to be refined. The unique capacities of human exploration is reviewed. The possible goals and objectives of the first three human missions are presented, along with the recommendation that the mission involve a long stay visiting multiple sites.The deployment strategy is outlined and diagrammed including the pre-deployment of the many of the material requirements, and a six crew travel to Mars on a six month trajectory. The predeployment and the Orion crew vehicle are shown. The ground operations requirements are also explained. Also the use of resources found on the surface of Mars is postulated. The Mars surface exploration strategy is reviewed, including the planetary protection processes that are planned. Finally a listing of the key decisions and tenets is posed.

UML Profiles for Design Decisions and Non-Functional Requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Liming; Gorton, Ian

2007-06-30

A software architecture is composed of a collection of design decisions. Each design decision helps or hinders certain Non-Functional Requirements (NFR). Current software architecture views focus on expressing components and connectors in the system. Design decisions and their relationships with non-functional requirements are often captured in separate design documentation, not explicitly expressed in any views. This disassociation makes architecture comprehension and architecture evolution harder. In this paper, we propose a UML profile for modeling design decisions and an associated UML profile for modeling non-functional requirements in a generic way. The two UML profiles treat design decisions and nonfunctional requirements asmore » first-class elements. Modeled design decisions always refer to existing architectural elements and thus maintain traceability between the two. We provide a mechanism for checking consistency over this traceability. An exemplar is given as« less

Design verification of large time constant thermal shields for optical reference cavities.

PubMed

Zhang, J; Wu, W; Shi, X H; Zeng, X Y; Deng, K; Lu, Z H

2016-02-01

In order to achieve high frequency stability in ultra-stable lasers, the Fabry-Pérot reference cavities shall be put inside vacuum chambers with large thermal time constants to reduce the sensitivity to external temperature fluctuations. Currently, the determination of thermal time constants of vacuum chambers is based either on theoretical calculation or time-consuming experiments. The first method can only apply to simple system, while the second method will take a lot of time to try out different designs. To overcome these limitations, we present thermal time constant simulation using finite element analysis (FEA) based on complete vacuum chamber models and verify the results with measured time constants. We measure the thermal time constants using ultrastable laser systems and a frequency comb. The thermal expansion coefficients of optical reference cavities are precisely measured to reduce the measurement error of time constants. The simulation results and the experimental results agree very well. With this knowledge, we simulate several simplified design models using FEA to obtain larger vacuum thermal time constants at room temperature, taking into account vacuum pressure, shielding layers, and support structure. We adopt the Taguchi method for shielding layer optimization and demonstrate that layer material and layer number dominate the contributions to the thermal time constant, compared with layer thickness and layer spacing.

Advances in Degradable Embolic Microspheres: A State of the Art Review

PubMed Central

Doucet, Jensen; Kiri, Lauren; O’Connell, Kathleen; Kehoe, Sharon; Lewandowski, Robert J.; Liu, David M.; Abraham, Robert J.; Boyd, Daniel

2018-01-01

Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies. PMID:29373510

Optical Air Flow Measurements in Flight

NASA Technical Reports Server (NTRS)

Bogue, Rodney K.; Jentink, Henk W.

2004-01-01

This document has been written to assist the flight-test engineer and researcher in using optical flow measurements in flight applications. The emphasis is on describing tradeoffs in system design to provide desired measurement performance as currently understood. Optical system components are discussed with examples that illustrate the issues. The document concludes with descriptions of optical measurement systems designed for a variety of applications including aeronautics research, airspeed measurement, and turbulence hazard detection. Theoretical discussion is minimized, but numerous references are provided to supply ample opportunity for the reader to understand the theoretical underpinning of optical concepts.

Fiberoptics technology and its application to propulsion control systems

NASA Technical Reports Server (NTRS)

Baumbick, R. J.

1983-01-01

Current work on optical sensors and optically controlled actuators for use in air-breathing engine control systems is reviewed with particular reference to the design and operation of several new fiber-optic devices. These include a tachometer, a rotary position encoder, a Fabry-Perot interferometer and a rare-earth sensor for measuring engine gas temperatures, a high-temperature photoswitch designed for the range -55 to 260 C, and optical cables and connectors. The advantages of optics over conventional wire systems used for sensing and actuator control are briefly discussed.

Study on Standard Fatigue Vehicle Load Model

NASA Astrophysics Data System (ADS)

Huang, H. Y.; Zhang, J. P.; Li, Y. H.

2018-02-01

Based on the measured data of truck from three artery expressways in Guangdong Province, the statistical analysis of truck weight was conducted according to axle number. The standard fatigue vehicle model applied to industrial areas in the middle and late was obtained, which adopted equivalence damage principle, Miner linear accumulation law, water discharge method and damage ratio theory. Compared with the fatigue vehicle model Specified by the current bridge design code, the proposed model has better applicability. It is of certain reference value for the fatigue design of bridge in China.

The natural space environment: Effects on spacecraft

NASA Technical Reports Server (NTRS)

James, Bonnie F.; Norton, O. W. (Compiler); Alexander, Margaret B. (Editor)

1994-01-01

The effects of the natural space environments on spacecraft design, development, and operation are the topic of a series of NASA Reference Publications currently being developed by the Electromagnetics and Environments Branch, Systems Analysis and Integration Laboratory, Marshall Space Flight Center. This primer provides an overview of the natural space environments and their effect on spacecraft design, development, and operations, and also highlights some of the new developments in science and technology for each space environment. It is hoped that a better understanding of the space environment and its effect on spacecraft will enable program management to more effectively minimize program risks and costs, optimize design quality, and successfully achieve mission objectives.

Effect of EEG Referencing Methods on Auditory Mismatch Negativity

PubMed Central

Mahajan, Yatin; Peter, Varghese; Sharma, Mridula

2017-01-01

Auditory event-related potentials (ERPs) have consistently been used in the investigation of auditory and cognitive processing in the research and clinical laboratories. There is currently no consensus on the choice of appropriate reference for auditory ERPs. The most commonly used references in auditory ERP research are the mathematically linked-mastoids (LM) and average referencing (AVG). Since LM and AVG referencing procedures do not solve the issue of electrically-neutral reference, Reference Electrode Standardization Technique (REST) was developed to create a neutral reference for EEG recordings. The aim of the current research is to compare the influence of the reference on amplitude and latency of auditory mismatch negativity (MMN) as a function of magnitude of frequency deviance across three commonly used electrode montages (16, 32, and 64-channel) using REST, LM, and AVG reference procedures. The current study was designed to determine if the three reference methods capture the variation in amplitude and latency of MMN with the deviance magnitude. We recorded MMN from 12 normal hearing young adults in an auditory oddball paradigm with 1,000 Hz pure tone as standard and 1,030, 1,100, and 1,200 Hz as small, medium and large frequency deviants, respectively. The EEG data recorded to these sounds was re-referenced using REST, LM, and AVG methods across 16-, 32-, and 64-channel EEG electrode montages. Results revealed that while the latency of MMN decreased with increment in frequency of deviant sounds, no effect of frequency deviance was present for amplitude of MMN. There was no effect of referencing procedure on the experimental effect tested. The amplitude of MMN was largest when the ERP was computed using LM referencing and the REST referencing produced the largest amplitude of MMN for 64-channel montage. There was no effect of electrode-montage on AVG referencing induced ERPs. Contrary to our predictions, the results suggest that the auditory MMN elicited as a function of increments in frequency deviance does not depend on the choice of referencing procedure. The results also suggest that auditory ERPs generated using REST referencing is contingent on the electrode arrays more than the AVG referencing. PMID:29066945

Inherent overload protection for the series resonant converter

NASA Technical Reports Server (NTRS)

King, R. J.; Stuart, T. A.

1983-01-01

The overload characteristics of the full bridge series resonant power converter are considered. This includes analyses of the two most common control methods presently in use. The first of these uses a current zero crossing detector to synchronize the control signals and is referred to as the alpha controller. The second is driven by a voltage controlled oscillator and is referred to as the gamma controller. It is shown that the gamma controller has certain reliability advantages in that it can be designed with inherent short circuit protection. Experimental results are included for an 86 kHz converter using power metal-oxide-semiconductor field-effect transistors (MOSFETs).

Basic coaxial mass driver reference design. [electromagnetic lunar launch

NASA Technical Reports Server (NTRS)

Kolm, H. H.

1977-01-01

The reference design for a basic coaxial mass driver is developed to illustrate the principles and optimization procedures on the basis of numerical integration by programmable pocket calculators. The four inch caliber system uses a single-coil bucket and a single-phase propulsion track with discrete coils, separately energized by capacitors. An actual driver would use multiple-coil buckets and an oscillatory multi-phase drive system. Even the basic, table-top demonstration system should in principle be able to achieve accelerations in the 1,000 m/sq sec range. Current densities of the order of 25 ka/sq cm, continuously achievable only in superconductors, are carried by an ordinary aluminum bucket coil for a short period in order to demonstrate the calculated acceleration. Ultimately the system can be lengthened and provided with a magnetically levitated, superconducting bucket to study levitation dynamics under quasi-steady-state conditions, and to approach lunar escape velocity in an evacuated tube.

Mars Surface Habitability Options

NASA Technical Reports Server (NTRS)

Howe, A. Scott; Simon, Matthew; Smitherman, David; Howard, Robert; Toups, Larry; Hoffman, Stephen J.

2015-01-01

This paper reports on current habitability concepts for an Evolvable Mars Campaign (EMC) prepared by the NASA Human Spaceflight Architecture Team (HAT). For many years NASA has investigated alternative human Mars missions, examining different mission objectives, trajectories, vehicles, and technologies; the combinations of which have been referred to as reference missions or architectures. At the highest levels, decisions regarding the timing and objectives for a human mission to Mars continue to evolve while at the lowest levels, applicable technologies continue to advance. This results in an on-going need for assessments of alternative system designs such as the habitat, a significant element in any human Mars mission scenario, to provide meaningful design sensitivity characterizations to assist decision-makers regarding timing, objectives, and technologies. As a subset of the Evolvable Mars Campaign activities, the habitability team builds upon results from past studies and recommends options for Mars surface habitability compatible with updated technologies.

Preliminary design of betavoltaic battery using Co-60 and Pm-147 with GaAs substrate

NASA Astrophysics Data System (ADS)

Waris, A.; Kusumawati, Y.; Alfarobi, A. S.; Aji, I. K.; Basar, K.

2016-03-01

Battery is very important for the present daily life, especially for portable devices. The longer utilization time the better performance of battery. Betavoltaic battery is a device that converts energy from beta decays of radioactive nuclide into electric current. One of merits of the later battery is the life time that can be more than ten years without recharging. To develop the betavoltaic battery for energy source of portable devices we have performed a preliminary simulation design of betavoltaic battery using Pm-147 and Co-60 a beta emitter radionuclides with n-GaAs substrate. From the results we found that the combination of Pm-147 with n-GaAs substrate results in 9.0% of efficiency and higher output current compared to references.

Digitally controlled twelve-pulse firing generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berde, D.; Ferrara, A.A.

1981-01-01

Control System Studies for the Tokamak Fusion Test Reactor (TFTR) indicate that accurate thyristor firing in the AC-to-DC conversion system is required in order to achieve good regulation of the various field currents. Rapid update and exact firing angle control are required to avoid instabilities, large eddy currents, or parasitic oscillations. The Prototype Firing Generator was designed to satisfy these requirements. To achieve the required /plus or minus/0.77/degree/firing accuracy, a three-phase-locked loop reference was designed; otherwise, the Firing Generator employs digital circuitry. The unit, housed in a standard CAMAC crate, operates under microcomputer control. Functions are performed under program control,more » which resides in nonvolatile read-only memory. Communication with CICADA control system is provided via an 11-bit parallel interface.« less

Cross-instrument Analysis Correlation Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

McJunkin, Timothy R.

This program has been designed to assist with the tracking of a sample from one analytical instrument to another such as SEM, microscopes, micro x-ray diffraction and other instruments where particular positions/locations on the sample are examined, photographed, etc. The software is designed to easily enter the position of fiducials and locations of interest such that in a future session in the same of different instrument the positions of interest can be re-found through using the known location fiducials in the current and reference session to transform the point into the current sessions coordinate system. The software is dialog boxmore » driven guiding the user through the necessary data entry and program choices. Information is stored in a series of text based extensible markup language (XML) files.« less

[Thinking on designation of sham acupuncture in clinical research].

PubMed

Pan, Li-Jia; Chen, Bo; Zhao, Xue; Guo, Yi

2014-01-01

Randomized controlled trials (RCT) is the source of the raw data of evidence-based medicine. Blind method is adopted in most of the high-quality RCT. Sham acupuncture is the main form of blinded in acupuncture clinical trial. In order to improve the quality of acupuncture clinical trail, based on the necessity of sham acupuncture in clinical research, the current situation as well as the existing problems of sham acupuncture, suggestions were put forward from the aspects of new way and new designation method which can be adopted as reference, and factors which have to be considered during the process of implementing. Various subjective and objective factors involving in the process of trial should be considered, and used of the current international standards, try to be quantification, and carry out strict quality monitoring.

Turbomachinery design considerations for the nuclear HTGR-GT power plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, C.F.; Smith, M.J.

1979-11-01

For several years, design studies have been under way in the USA on a nuclear closed-cycle gas turbine plant (HTGR-GT). Design aspects of the helium turbomachine portion of these studies are presented. Gas dynamic and mechanical design considerations are presented for helium turbomachines in the 400-MW(e) (non-intercooled) and 600-MW(e) (intercooled) power range. Design of the turbomachine is a key element in the overall power plant program effort, which is currently directed toward the selection of a reference HTGR-GT commercial plant configuration for the US utility market. A conservative design approach has been emphasized to provide maximum safety and durability. Themore » studies presented for the integrated plant concept outline the necessary close working relationship between the reactor primary system and turbomachine designers.« less

Nocturnal oxygen saturation profiles of healthy term infants

PubMed Central

Terrill, Philip Ian; Dakin, Carolyn; Hughes, Ian; Yuill, Maggie; Parsley, Chloe

2015-01-01

Objective Pulse oximetry is used extensively in hospital and home settings to measure arterial oxygen saturation (SpO2). Interpretation of the trend and range of SpO2 values observed in infants is currently limited by a lack of reference ranges using current devices, and may be augmented by development of cumulative frequency (CF) reference-curves. This study aims to provide reference oxygen saturation values from a prospective longitudinal cohort of healthy infants. Design Prospective longitudinal cohort study. Setting Sleep-laboratory. Patients 34 healthy term infants were enrolled, and studied at 2 weeks, 3, 6, 12 and 24 months of age (N=30, 25, 27, 26, 20, respectively). Interventions Full overnight polysomnography, including 2 s averaging pulse oximetry (Masimo Radical). Main outcome measurements Summary SpO2 statistics (mean, median, 5th and 10th percentiles) and SpO2 CF plots were calculated for each recording. CF reference-curves were then generated for each study age. Analyses were repeated with sleep-state stratifications and inclusion of manual artefact removal. Results Median nocturnal SpO2 values ranged between 98% and 99% over the first 2 years of life and the CF reference-curves shift right by 1% between 2 weeks and 3 months. CF reference-curves did not change with manual artefact removal during sleep and did not vary between rapid eye movement (REM) and non-REM sleep. Manual artefact removal did significantly change summary statistics and CF reference-curves during wake. Conclusions SpO2 CF curves provide an intuitive visual tool for evaluating whether an individual's nocturnal SpO2 distribution falls within the range of healthy age-matched infants, thereby complementing summary statistics in the interpretation of extended oximetry recordings in infants. PMID:25063836

A novel EPID design for enhanced contrast and detective quantum efficiency

NASA Astrophysics Data System (ADS)

Rottmann, Joerg; Morf, Daniel; Fueglistaller, Rony; Zentai, George; Star-Lack, Josh; Berbeco, Ross

2016-09-01

Beams-eye-view imaging applications such as real-time soft-tissue motion estimation are hindered by the inherently low image contrast of electronic portal imaging devices (EPID) currently available for clinical use. We introduce and characterize a novel EPID design that provides substantially increased detective quantum efficiency (DQE), contrast-to-noise ratio (CNR) and sensitivity without degradation in spatial resolution. The prototype design features a stack of four conventional EPID layers combined with low noise integrated readout electronics. Each layer consists of a copper plate, a scintillator (\\text{G}{{\\text{d}}2}{{\\text{O}}2}{{\\text{S}}{}}\\text{:Tb} ) and a photodiode/TFT-switch (aSi:H). We characterize the prototype’s signal response to a 6 MV photon beam in terms of modulation transfer function (MTF), DQE and CNR. The presampled MTF is estimated using a slanted slit technique, the DQE is calculated from measured normalized noise power spectra (nNPS) and the MTF and CNR is estimated using a Las Vegas contrast phantom. The prototype has been designed and built to be interchangeable with the current clinical EPID on the Varian TrueBeam platform (AS-1200) in terms of size and data output specifications. Performance evaluation is conducted in absolute values as well as in relative terms using the Varian AS-1200 EPID as a reference detector. A fivefold increase of DQE(0) to about 6.7% was observed by using the four-layered design versus the AS-1200 reference detector. No substantial differences are observed between each layer’s individual MTF and the one for all four layers operating combined indicating that defocusing due to beam divergence is negligible. Also, using four layers instead of one increases the signal to noise ratio by a factor of 1.7.

TLOG: Training and Educating Operational Logistic Planners

DTIC Science & Technology

2008-05-22

monograph recommends specific changes to the current curriculum. Additions in operational knowledge provide the students technical knowledge and a...common frame of reference in campaign planning. The changes result in students not only technically competent to design a concept of support, but...planning process. The implementation of these changes enhance TLog’s curriculum to meet the course’s stated goal; the graduates will be the

STATLIB: NSWC Library of Statistical Programs and Subroutines

DTIC Science & Technology

1989-08-01

Uncorrelated Weighted Polynomial Regression 41 .WEPORC Correlated Weighted Polynomial Regression 45 MROP Multiple Regression Using Orthogonal Polynomials ...could not and should not be con- NSWC TR 89-97 verted to the new general purpose computer (the current CDC 995). Some were designed tu compute...personal computers. They are referred to as SPSSPC+, BMDPC, and SASPC and in general are less comprehensive than their mainframe counterparts. The basic

Constructing Quality Feedback to the Students in Distance Learning: Review of the Current Evidence with Reference to the Online Master Degree in Transplantation

ERIC Educational Resources Information Center

Halawa, Ahmed; Sharma, Ajay; Bridson, Julie M.; Lyon, Sarah; Prescott, Denise; Guha, Arpan; Taylor, David

2017-01-01

Introduction: It was a challenge to design a feedback pathway for distance learning course that deals with complex and ambiguous clinical subject like organ transplantation. This course attracts mature clinicians (n = 117 spread over three modules) from 27 countries where in addition to the time and zone barriers; there are cultural, institutional…

Measurement and Characterization of Space Shuttle Solid Rocket Motor Plume Acoustics

NASA Technical Reports Server (NTRS)

Kenny, Jeremy; Hobbs, Chris; Plotkin, Ken; Pilkey, Debbie

2009-01-01

Lift-off acoustic environments generated by the future Ares I launch vehicle are assessed by the NASA Marshall Space Flight Center (MSFC) acoustics team using several prediction tools. This acoustic environment is directly caused by the Ares I First Stage booster, powered by the five-segment Reusable Solid Rocket Motor (RSRMV). The RSRMV is a larger-thrust derivative design from the currently used Space Shuttle solid rocket motor, the Reusable Solid Rocket Motor (RSRM). Lift-off acoustics is an integral part of the composite launch vibration environment affecting the Ares launch vehicle and must be assessed to help generate hardware qualification levels and ensure structural integrity of the vehicle during launch and lift-off. Available prediction tools that use free field noise source spectrums as a starting point for generation of lift-off acoustic environments are described in the monograph NASA SP-8072: "Acoustic Loads Generated by the Propulsion System." This monograph uses a reference database for free field noise source spectrums which consist of subscale rocket motor firings, oriented in horizontal static configurations. The phrase "subscale" is appropriate, since the thrust levels of rockets in the reference database are orders of magnitude lower than the current design thrust for the Ares launch family. Thus, extrapolation is needed to extend the various reference curves to match Ares-scale acoustic levels. This extrapolation process yields a subsequent amount of uncertainty added upon the acoustic environment predictions. As the Ares launch vehicle design schedule progresses, it is important to take every opportunity to lower prediction uncertainty and subsequently increase prediction accuracy. Never before in NASA s history has plume acoustics been measured for large scale solid rocket motors. Approximately twice a year, the RSRM prime vendor, ATK Launch Systems, static fires an assembled RSRM motor in a horizontal configuration at their test facility in Utah. The remaining RSRM static firings will take place on elevated terrain, with the nozzle exit plume being mostly undeflected and the landscape allowing placement of microphones within direct line of sight to the exhaust plume. These measurements will help assess the current extrapolation process by direct comparison between subscale and full scale solid rocket motor data.

What is the best reference RNA? And other questions regarding the design and analysis of two-color microarray experiments.

PubMed

Kerr, Kathleen F; Serikawa, Kyle A; Wei, Caimiao; Peters, Mette A; Bumgarner, Roger E

2007-01-01

The reference design is a practical and popular choice for microarray studies using two-color platforms. In the reference design, the reference RNA uses half of all array resources, leading investigators to ask: What is the best reference RNA? We propose a novel method for evaluating reference RNAs and present the results of an experiment that was specially designed to evaluate three common choices of reference RNA. We found no compelling evidence in favor of any particular reference. In particular, a commercial reference showed no advantage in our data. Our experimental design also enabled a new way to test the effectiveness of pre-processing methods for two-color arrays. Our results favor using intensity normalization and foregoing background subtraction. Finally, we evaluate the sensitivity and specificity of data quality filters, and we propose a new filter that can be applied to any experimental design and does not rely on replicate hybridizations.

Method and apparatus for measuring low currents in capacitance devices

DOEpatents

Kopp, M.K.; Manning, F.W.; Guerrant, G.C.

1986-06-04

A method and apparatus for measuring subnanoampere currents in capacitance devices is reported. The method is based on a comparison of the voltages developed across the capacitance device with that of a reference capacitor in which the current is adjusted by means of a variable current source to produce a stable voltage difference. The current varying means of the variable current source is calibrated to provide a read out of the measured current. Current gain may be provided by using a reference capacitor which is larger than the device capacitance with a corresponding increase in current supplied through the reference capacitor. The gain is then the ratio of the reference capacitance to the device capacitance. In one illustrated embodiment, the invention makes possible a new type of ionizing radiation dose-rate monitor where dose-rate is measured by discharging a reference capacitor with a variable current source at the same rate that radiation is discharging an ionization chamber. The invention eliminates high-megohm resistors and low current ammeters used in low-current measuring instruments.

Electromotive force analysis of current transformer during lightning surge inflow using Fourier series expansion

NASA Astrophysics Data System (ADS)

Kim, Youngsun

2017-05-01

The most common structure used for current transformers (CTs) consists of secondary windings around a ferromagnetic core past the primary current being measured. A CT used as a surge protection device (SPD) may experience large inrushes of current, like surges. However, when a large current flows into the primary winding, measuring the magnitude of the current is difficult because the ferromagnetic core becomes magnetically saturated. Several approaches to reduce the saturation effect are described in the literature. A Rogowski coil is representative of several devices that measure large currents. It is an electrical device that measures alternating current (AC) or high-frequency current. However, such devices are very expensive in application. In addition, the volume of a CT must be increased to measure sufficiently large currents, but for installation spaces that are too small, other methods must be used. To solve this problem, it is necessary to analyze the magnetic field and electromotive force (EMF) characteristics when designing a CT. Thus, we proposed an analysis method for the CT under an inrush current using the time-domain finite element method (TDFEM). The input source current of a surge waveform is expanded by a Fourier series to obtain an instantaneous value. An FEM model of the device is derived in a two-dimensional system and coupled with EMF circuits. The time-derivative term in the differential equation is solved in each time step by the finite difference method. It is concluded that the proposed algorithm is useful for analyzing CT characteristics, including the field distribution. Consequently, the proposed algorithm yields a reference for obtaining the effects of design parameters and magnetic materials for special shapes and sizes before the CT is designed and manufactured.

Design of H2-O2 space shuttle APU. Volume 1: APU design

NASA Technical Reports Server (NTRS)

Harris, E.

1974-01-01

The H2-O2 space shuttle auxiliary power unit (APU) program is a NASA-Lewis effort aimed at hardware demonstration of the technology required for potential use on the space shuttle. It has been shown that a hydrogen-oxygen power unit (APU) system is an attractive alternate to the space shuttle baseline hydrazine APU system for minimum weight. It has the capability for meeting many of the heat sink requirements for the space shuttle vehicle, thereby reducing the amount of expendable evaporants required for cooling in the baseline APU. Volume 1 of this report covers preliminary design and analysis of the current reference system and detail design of the test version of this reference system. Combustor test results are also included. Volume 2 contains the results of the analysis of an initial version of the reference system and the computer printouts of system performance. The APU consists of subsystems for propellant feed and conditioning, turbopower, and control. Propellant feed and conditioning contains all heat exchangers, valves, and the combustor. The turbopower subsystem contains a two-stage partial-admission pressure-modulated, 400-hp, 63,000-rpm turbine, a 0-to 4-g lubrication system, and a gearbox with output pads for two hydraulic pumps and an alternator (alternator not included on test unit). The electronic control functions include regulation of speed and system temperatures; and start-and-stop sequences, overspeed (rpm) and temperature limits, failsafe provisions, and automatic shutdown provisions.

Single point aerosol sampling: evaluation of mixing and probe performance in a nuclear stack.

PubMed

Rodgers, J C; Fairchild, C I; Wood, G O; Ortiz, C A; Muyshondt, A; McFarland, A R

1996-01-01

Alternative reference methodologies have been developed for sampling of radionuclides from stacks and ducts, which differ from the methods previously required by the United States Environmental Protection Agency. These alternative reference methodologies have recently been approved by the U.S. EPA for use in lieu of the current standard techniques. The standard EPA methods are prescriptive in selection of sampling locations and in design of sampling probes whereas the alternative reference methodologies are performance driven. Tests were conducted in a stack at Los Alamos National Laboratory to demonstrate the efficacy of some aspects of the alternative reference methodologies. Coefficients of variation of velocity, tracer gas, and aerosol particle profiles were determined at three sampling locations. Results showed that numerical criteria placed upon the coefficients of variation by the alternative reference methodologies were met at sampling stations located 9 and 14 stack diameters from the flow entrance, but not at a location that was 1.5 diameters downstream from the inlet. Experiments were conducted to characterize the transmission of 10 microns aerodynamic diameter liquid aerosol particles through three types of sampling probes. The transmission ratio (ratio of aerosol concentration at the probe exit plane to the concentration in the free stream) was 107% for a 113 L min-1 (4-cfm) anisokinetic shrouded probe, but only 20% for an isokinetic probe that follows the existing EPA standard requirements. A specially designed isokinetic probe showed a transmission ratio of 63%. The shrouded probe performance would conform to the alternative reference methodologies criteria; however, the isokinetic probes would not.

Positioning navigation and timing service applications in cyber physical systems

NASA Astrophysics Data System (ADS)

Qu, Yi; Wu, Xiaojing; Zeng, Lingchuan

2017-10-01

The positioning navigation and timing (PNT) architecture was discussed in detail, whose history, evolvement, current status and future plan were presented, main technologies were listed, advantages and limitations of most technologies were compared, novel approaches were introduced, and future capacities were sketched. The concept of cyber-physical system (CPS) was described and their primary features were interpreted. Then the three-layer architecture of CPS was illustrated. Next CPS requirements on PNT services were analyzed, including requirements on position reference and time reference, requirements on temporal-spatial error monitor, requirements on dynamic services, real-time services, autonomous services, security services and standard services. Finally challenges faced by PNT applications in CPS were concluded. The conclusion was expected to facilitate PNT applications in CPS, and furthermore to provide references to the design and implementation of both architectures.

Analysis of a spacecraft life support system for a Mars mission.

PubMed

Czupalla, M; Aponte, V; Chappell, S; Klaus, D

2004-01-01

This report summarizes a trade study conducted as part of the Fall 2002 semester Spacecraft Life Support System Design course (ASEN 5116) in the Aerospace Engineering Sciences Department at the University of Colorado. It presents an analysis of current life support system technologies and a preliminary design of an integrated system for supporting humans during transit to and on the surface of the planet Mars. This effort was based on the NASA Design Reference Mission (DRM) for the human exploration of Mars [NASA Design Reference Mission (DRM) for Mars, Addendum 3.0, from the world wide web: http://exploration.jsc.nasa.gov/marsref/contents.html.]. The integrated design was broken into four subsystems: Water Management, Atmosphere Management, Waste Processing, and Food Supply. The process started with the derivation of top-level requirements from the DRM. Additional system and subsystem level assumptions were added where clarification was needed. Candidate technologies were identified and characterized based on performance factors. Trade studies were then conducted for each subsystem. The resulting technologies were integrated into an overall design solution using mass flow relationships. The system level trade study yielded two different configurations--one for the transit to Mars and another for the surface habitat, which included in situ resource utilization. Equivalent System Mass analyses were used to compare each design against an open-loop (non-regenerable) baseline system. c2003 International Astronautical Federation. Published by Elsevier Ltd. All rights reserved.

Reference field specification and preliminary beam selection strategy for accelerator-based GCR simulation

NASA Astrophysics Data System (ADS)

Slaba, Tony C.; Blattnig, Steve R.; Norbury, John W.; Rusek, Adam; La Tessa, Chiara

2016-02-01

The galactic cosmic ray (GCR) simulator at the NASA Space Radiation Laboratory (NSRL) is intended to deliver the broad spectrum of particles and energies encountered in deep space to biological targets in a controlled laboratory setting. In this work, certain aspects of simulating the GCR environment in the laboratory are discussed. Reference field specification and beam selection strategies at NSRL are the main focus, but the analysis presented herein may be modified for other facilities and possible biological considerations. First, comparisons are made between direct simulation of the external, free space GCR field and simulation of the induced tissue field behind shielding. It is found that upper energy constraints at NSRL limit the ability to simulate the external, free space field directly (i.e. shielding placed in the beam line in front of a biological target and exposed to a free space spectrum). Second, variation in the induced tissue field associated with shielding configuration and solar activity is addressed. It is found that the observed variation is likely within the uncertainty associated with representing any GCR reference field with discrete ion beams in the laboratory, given current facility constraints. A single reference field for deep space missions is subsequently identified. Third, a preliminary approach for selecting beams at NSRL to simulate the designated reference field is presented. This approach is not a final design for the GCR simulator, but rather a single step within a broader design strategy. It is shown that the beam selection methodology is tied directly to the reference environment, allows facility constraints to be incorporated, and may be adjusted to account for additional constraints imposed by biological or animal care considerations. The major biology questions are not addressed herein but are discussed in a companion paper published in the present issue of this journal. Drawbacks of the proposed methodology are discussed and weighed against alternative simulation strategies.

Network-based production quality control

NASA Astrophysics Data System (ADS)

Kwon, Yongjin; Tseng, Bill; Chiou, Richard

2007-09-01

This study investigates the feasibility of remote quality control using a host of advanced automation equipment with Internet accessibility. Recent emphasis on product quality and reduction of waste stems from the dynamic, globalized and customer-driven market, which brings opportunities and threats to companies, depending on the response speed and production strategies. The current trends in industry also include a wide spread of distributed manufacturing systems, where design, production, and management facilities are geographically dispersed. This situation mandates not only the accessibility to remotely located production equipment for monitoring and control, but efficient means of responding to changing environment to counter process variations and diverse customer demands. To compete under such an environment, companies are striving to achieve 100%, sensor-based, automated inspection for zero-defect manufacturing. In this study, the Internet-based quality control scheme is referred to as "E-Quality for Manufacturing" or "EQM" for short. By its definition, EQM refers to a holistic approach to design and to embed efficient quality control functions in the context of network integrated manufacturing systems. Such system let designers located far away from the production facility to monitor, control and adjust the quality inspection processes as production design evolves.

Research the mobile phone operation interfaces for vision-impairment.

PubMed

Yao, Yen-Ting; Leung, Cherng-Yee

2012-01-01

Due to the vision-impaired users commonly having difficulty with mobile-phone function operations and adaption any manufacturer's user interface design, the goals for this research are established for evaluating how to improve for them the function operation convenience and user interfaces of either mobile phones or electronic appliances in the market currently. After applying collecting back 30 effective questionnaires from 30 vision-impairment, the comments have been concluded from this research include: (1) All mobile phone manufactures commonly ignorant of the vision-impairment difficulty with operating mobile phone user interfaces; (2) The vision-impairment preferential with audio alert signals; (3) The vision-impairment incapable of mobile-phone procurement independently unless with assistance from others; (4) Preferential with adding touch-usage interface design by the vision-impairment; in contrast with the least requirement for such functions as braille, enlarging keystroke size and diversifying-function control panel. With exploring the vision-impairment's necessary improvements and obstacles for mobile phone interface operation, this research is established with goals for offering reference possibly applied in electronic appliance design and . Hopefully, the analysis results of this research could be used as data references for designing electronic and high-tech products and promoting more usage convenience for those vision-impaired.

Current control of PMSM based on maximum torque control reference frame

NASA Astrophysics Data System (ADS)

Ohnuma, Takumi

2017-07-01

This study presents a new method of current controls of PMSMs (Permanent Magnet Synchronous Motors) based on a maximum torque control reference frame, which is suitable for high-performance controls of the PMSMs. As the issues of environment and energy increase seriously, PMSMs, one of the AC motors, are becoming popular because of their high-efficiency and high-torque density in various applications, such as electric vehicles, trains, industrial machines, and home appliances. To use the PMSMs efficiently, a proper current control of the PMSMs is necessary. In general, a rotational coordinate system synchronizing with the rotor is used for the current control of PMSMs. In the rotating reference frame, the current control is easier because the currents on the rotating reference frame can be expressed as a direct current in the controller. On the other hand, the torque characteristics of PMSMs are non-linear and complex; the PMSMs are efficient and high-density though. Therefore, a complicated control system is required to involve the relation between the torque and the current, even though the rotating reference frame is adopted. The maximum torque control reference frame provides a simpler way to control efficiently the currents taking the torque characteristics of the PMSMs into consideration.

Status of NGS CORS Network and Its Contribution to the GGOS Infrastructure

NASA Astrophysics Data System (ADS)

Choi, K. K.; Haw, D.; Sun, L.

2017-12-01

Recent advancement of Satellite Geodesy techniques can now contribute to the global frame realization needed to improve worldwide accuracies. These techniques rely on coordinates computed using continuously observed GPS data and corresponding satellite orbits. The GPS-based reference system continues to depend on the physical stability of a ground-based network of points as the primary foundation for these observations. NOAA's National Geodetic Survey (NGS) has been operating Continuously Operating Reference Stations (CORS) to provide direct access to the National Spatial Reference System (NSRS). By virtue of NGS' scientific reputation and leadership in national and international geospatial issues, NGS has determined to increase its participation in the maintenance of the U.S. component of the global GPS tracking network in order to realize a long-term stable national terrestrial reference frame. NGS can do so by leveraging its national leadership role coupled with NGS' scientific expertise, in designating and upgrading a subset of the current tracking network for this purpose. This subset of stations must have the highest operational standards to serve the dual functions: being the U.S. contribution to the international frame, along with providing the link to the national datum. These stations deserve special attention to ensure that the highest possible levels of quality and stability are maintained. To meet this need, NGS is working with the international scientific groups to add and designate these reference stations based on scientific merit such as: colocation with other geodetic techniques, geographic area, and monumentation stability.

Interlaboratory comparison measurements of aspheres

NASA Astrophysics Data System (ADS)

Schachtschneider, R.; Fortmeier, I.; Stavridis, M.; Asfour, J.; Berger, G.; Bergmann, R. B.; Beutler, A.; Blümel, T.; Klawitter, H.; Kubo, K.; Liebl, J.; Löffler, F.; Meeß, R.; Pruss, C.; Ramm, D.; Sandner, M.; Schneider, G.; Wendel, M.; Widdershoven, I.; Schulz, M.; Elster, C.

2018-05-01

The need for high-quality aspheres is rapidly growing, necessitating increased accuracy in their measurement. A reliable uncertainty assessment of asphere form measurement techniques is difficult due to their complexity. In order to explore the accuracy of current asphere form measurement techniques, an interlaboratory comparison was carried out in which four aspheres were measured by eight laboratories using tactile measurements, optical point measurements, and optical areal measurements. Altogether, 12 different devices were employed. The measurement results were analysed after subtracting the design topography and subsequently a best-fit sphere from the measurements. The surface reduced in this way was compared to a reference topography that was obtained by taking the pointwise median across the ensemble of reduced topographies on a 1000 × 1000 Cartesian grid. The deviations of the reduced topographies from the reference topography were analysed in terms of several characteristics including peak-to-valley and root-mean-square deviations. Root-mean-square deviations of the reduced topographies from the reference topographies were found to be on the order of some tens of nanometres up to 89 nm, with most of the deviations being smaller than 20 nm. Our results give an indication of the accuracy that can currently be expected in form measurements of aspheres.

Applying Strategic Visualization(Registered Trademark) to Lunar and Planetary Mission Design

NASA Technical Reports Server (NTRS)

Frassanito, John R.; Cooke, D. R.

2002-01-01

NASA teams, such as the NASA Exploration Team (NEXT), utilize advanced computational visualization processes to develop mission designs and architectures for lunar and planetary missions. One such process, Strategic Visualization (trademark), is a tool used extensively to help mission designers visualize various design alternatives and present them to other participants of their team. The participants, which may include NASA, industry, and the academic community, are distributed within a virtual network. Consequently, computer animation and other digital techniques provide an efficient means to communicate top-level technical information among team members. Today,Strategic Visualization(trademark) is used extensively both in the mission design process within the technical community, and to communicate the value of space exploration to the general public. Movies and digital images have been generated and shown on nationally broadcast television and the Internet, as well as in magazines and digital media. In our presentation will show excerpts of a computer-generated animation depicting the reference Earth/Moon L1 Libration Point Gateway architecture. The Gateway serves as a staging corridor for human expeditions to the lunar poles and other surface locations. Also shown are crew transfer systems and current reference lunar excursion vehicles as well as the Human and robotic construction of an inflatable telescope array for deployment to the Sun/Earth Libration Point.

Low-sensitivity, low-bounce, high-linearity current-controlled oscillator suitable for single-supply mixed-mode instrumentation system.

PubMed

Hwang, Yuh-Shyan; Kung, Che-Min; Lin, Ho-Cheng; Chen, Jiann-Jong

2009-02-01

A low-sensitivity, low-bounce, high-linearity current-controlled oscillator (CCO) suitable for a single-supply mixed-mode instrumentation system is designed and proposed in this paper. The designed CCO can be operated at low voltage (2 V). The power bounce and ground bounce generated by this CCO is less than 7 mVpp when the power-line parasitic inductance is increased to 100 nH to demonstrate the effect of power bounce and ground bounce. The power supply noise caused by the proposed CCO is less than 0.35% in reference to the 2 V supply voltage. The average conversion ratio KCCO is equal to 123.5 GHz/A. The linearity of conversion ratio is high and its tolerance is within +/-1.2%. The sensitivity of the proposed CCO is nearly independent of the power supply voltage, which is less than a conventional current-starved oscillator. The performance of the proposed CCO has been compared with the current-starved oscillator. It is shown that the proposed CCO is suitable for single-supply mixed-mode instrumentation systems.

Current-horn suppression for reduced coherent-synchrotron-radiation-induced emittance growth in strong bunch compression

NASA Astrophysics Data System (ADS)

Charles, T. K.; Paganin, D. M.; Latina, A.; Boland, M. J.; Dowd, R. T.

2017-03-01

Control of coherent synchrotron radiation (CSR)-induced emittance growth is essential in linear accelerators designed to deliver very high brightness electron beams. Extreme current values at the head and tail of the electron bunch, resulting from strong bunch compression, are responsible for large CSR production leading to significant transverse projected emittance growth. The Linac Coherent Light Source (LCLS) truncates the head and tail current spikes which greatly improves free electron laser (FEL) performance. Here we consider the underlying dynamics that lead to formation of current spikes (also referred to as current horns), which has been identified as caustics forming in electron trajectories. We present a method to analytically determine conditions required to avoid the caustic formation and therefore prevent the current spikes from forming. These required conditions can be easily met, without increasing the transverse slice emittance, through inclusion of an octupole magnet in the middle of a bunch compressor.

Use of artificial intelligence in supervisory control

NASA Technical Reports Server (NTRS)

Cohen, Aaron; Erickson, Jon D.

1989-01-01

Viewgraphs describing the design and testing of an intelligent decision support system called OFMspert are presented. In this expert system, knowledge about the human operator is represented through an operator/system model referred to as the OFM (Operator Function Model). OFMspert uses the blackboard model of problem solving to maintain a dynamic representation of operator goals, plans, tasks, and actions given previous operator actions and current system state. Results of an experiment to assess OFMspert's intent inferencing capability are outlined. Finally, the overall design philosophy for an intelligent tutoring system (OFMTutor) for operators of complex dynamic systems is summarized.

A High Resolution Radar Altimeter to Measure the Topography of Ice Sheets

NASA Technical Reports Server (NTRS)

Pawul, Rudolf A.

1997-01-01

This thesis is a reference for the Advanced Application Flight Experiment (AAFE) altimeter. The transmitter and receiver subsections are described and measurements of their current state is provided. During the 1994 NASA Greenland Experiment, the altimeter experienced several hardware malfunctions. The process of returning the radar to its fully operational state is presented in detail and necessary design modifications are explained. An updated radar user's manual is included along with various circuit designs which need to be implemented. The thesis is intended to provide an incoming graduate student with a solid foundation of the fundamentals of AAFE altimeter operation.

Physical Model Study of Cross Vanes and Ice

DTIC Science & Technology

2009-08-01

spacing since, in the pre-scour state, experiments and the HEC - RAS hydraulic model (USACE 2002b) found that water surface ele- vation merged with the...docs/eng-manuals/em1110- 2-1612/toc.htm. USACE (2002b) HEC - RAS , Hydraulic Reference Manual. US Army Corps of Engineers Hydrologic Engineering Center...Currently little design guidance is available for constructing these structures on ice-affected rivers . This study used physical and numerical

Commercial compact cyclotrons in the 90`s

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference tomore » those demands that differ from those in a research oriented cyclotron project. The authors also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA.« less

[Concepts of development of the neurosurgical operative environment in the 21st century].

PubMed

Apuzzo, M; Liu, C

2002-01-01

The operative environment has to a large extent defines the "state of the art and science" of neurosurgery, which is now undergoing rapid reinvention. In order to remain current, each neurosurgeon should periodically reconsider their personal operative environment and its functional design with reference to modernity of practice as currently defined. Historical trends and their analysis offer predictive guides for development of such settings with an eye toward the future. Examination of technical developments in decade timeframes defines the progress in capability and need. Progressive minimalism of manipulation and the presence of operative definition with increasing precision are evident, with concurrent miniaturization of attendant computerized support systems, sensors, robotic interfaces, and imaging devices. These trends and developments offer the opportunity for simplificity of setting design with higher functionality as the desired endpoint.

Preliminary design of betavoltaic battery using Co-60 and Pm-147 with GaAs substrate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waris, A., E-mail: awaris@fi.itb.ac.id; Basar, K.; Kusumawati, Y.

Battery is very important for the present daily life, especially for portable devices. The longer utilization time the better performance of battery. Betavoltaic battery is a device that converts energy from beta decays of radioactive nuclide into electric current. One of merits of the later battery is the life time that can be more than ten years without recharging. To develop the betavoltaic battery for energy source of portable devices we have performed a preliminary simulation design of betavoltaic battery using Pm-147 and Co-60 a beta emitter radionuclides with n-GaAs substrate. From the results we found that the combination ofmore » Pm-147 with n-GaAs substrate results in 9.0% of efficiency and higher output current compared to references.« less

High-Performance Optical Frequency References for Space

NASA Astrophysics Data System (ADS)

Schuldt, Thilo; Döringshoff, Klaus; Milke, Alexander; Sanjuan, Josep; Gohlke, Martin; Kovalchuk, Evgeny V.; Gürlebeck, Norman; Peters, Achim; Braxmaier, Claus

2016-06-01

A variety of future space missions rely on the availability of high-performance optical clocks with applications in fundamental physics, geoscience, Earth observation and navigation and ranging. Examples are the gravitational wave detector eLISA (evolved Laser Interferometer Space Antenna), the Earth gravity mission NGGM (Next Generation Gravity Mission) and missions, dedicated to tests of Special Relativity, e.g. by performing a Kennedy- Thorndike experiment testing the boost dependence of the speed of light. In this context we developed optical frequency references based on Doppler-free spectroscopy of molecular iodine; compactness and mechanical and thermal stability are main design criteria. With a setup on engineering model (EM) level we demonstrated a frequency stability of about 2·10-14 at an integration time of 1 s and below 6·10-15 at integration times between 100s and 1000s, determined from a beat-note measurement with a cavity stabilized laser where a linear drift was removed from the data. A cavity-based frequency reference with focus on improved long-term frequency stability is currently under development. A specific sixfold thermal shield design based on analytical methods and numerical calculations is presented.

GTX Reference Vehicle Structural Verification Methods and Weight Summary

NASA Technical Reports Server (NTRS)

Hunter, J. E.; McCurdy, D. R.; Dunn, P. W.

2002-01-01

The design of a single-stage-to-orbit air breathing propulsion system requires the simultaneous development of a reference launch vehicle in order to achieve the optimal mission performance. Accordingly, for the GTX study a 300-lb payload reference vehicle was preliminary sized to a gross liftoff weight (GLOW) of 238,000 lb. A finite element model of the integrated vehicle/propulsion system was subjected to the trajectory environment and subsequently optimized for structural efficiency. This study involved the development of aerodynamic loads mapped to finite element models of the integrated system in order to assess vehicle margins of safety. Commercially available analysis codes were used in the process along with some internally developed spread-sheets and FORTRAN codes specific to the GTX geometry for mapping of thermal and pressure loads. A mass fraction of 0.20 for the integrated system dry weight has been the driver for a vehicle design consisting of state-of-the-art composite materials in order to meet the rigid weight requirements. This paper summarizes the methodology used for preliminary analyses and presents the current status of the weight optimization for the structural components of the integrated system.

GTX Reference Vehicle Structural Verification Methods and Weight Summary

NASA Technical Reports Server (NTRS)

Hunter, J. E.; McCurdy, D. R.; Dunn, P. W.

2002-01-01

The design of a single-stage-to-orbit air breathing propulsion system requires the simultaneous development of a reference launch vehicle in order to achieve the optimal mission performance. Accordingly, for the GTX study a 300-lb payload reference vehicle was preliminarily sized to a gross liftoff weight (GLOW) of 238,000 lb. A finite element model of the integrated vehicle/propulsion system was subjected to the trajectory environment and subsequently optimized for structural efficiency. This study involved the development of aerodynamic loads mapped to finite element models of the integrated system in order to assess vehicle margins of safety. Commercially available analysis codes were used in the process along with some internally developed spreadsheets and FORTRAN codes specific to the GTX geometry for mapping of thermal and pressure loads. A mass fraction of 0.20 for the integrated system dry weight has been the driver for a vehicle design consisting of state-of-the-art composite materials in order to meet the rigid weight requirements. This paper summarizes the methodology used for preliminary analyses and presents the current status of the weight optimization for the structural components of the integrated system.

Optimization of the ITER electron cyclotron equatorial launcher for improved heating and current drive functional capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farina, D.; Figini, L.; Henderson, M.

2014-06-15

The design of the ITER Electron Cyclotron Heating and Current Drive (EC H and CD) system has evolved in the last years both in goals and functionalities by considering an expanded range of applications. A large effort has been devoted to a better integration of the equatorial and the upper launchers, both from the point of view of the performance and of the design impact on the engineering constraints. However, from the analysis of the ECCD performance in two references H-mode scenarios at burn (the inductive H-mode and the advanced non-inductive scenario), it was clear that the EC power depositionmore » was not optimal for steady-state applications in the plasma region around mid radius. An optimization study of the equatorial launcher is presented here aiming at removing this limitation of the EC system capabilities. Changing the steering of the equatorial launcher from toroidal to poloidal ensures EC power deposition out to the normalized toroidal radius ρ ≈ 0.6, and nearly doubles the EC driven current around mid radius, without significant performance degradation in the core plasma region. In addition to the improved performance, the proposed design change is able to relax some engineering design constraints on both launchers.« less

Eddy-Current Reference Standard

NASA Technical Reports Server (NTRS)

Ambrose, H. H., Jr.

1985-01-01

Magnetic properties of metallic reference standards duplicated and stabilized for eddy-current coil measurements over long times. Concept uses precisely machined notched samples of known annealed materials as reference standards.

A new type of accelerator power supply based on voltage-type space vector PWM rectification technology

NASA Astrophysics Data System (ADS)

Wu, Fengjun; Gao, Daqing; Shi, Chunfeng; Huang, Yuzhen; Cui, Yuan; Yan, Hongbin; Zhang, Huajian; Wang, Bin; Li, Xiaohui

2016-08-01

To solve the problems such as low input power factor, a large number of AC current harmonics and instable DC bus voltage due to the diode or thyristor rectifier used in an accelerator power supply, particularly in the Heavy Ion Research Facility in Lanzhou-Cooler Storage Ring (HIRFL-CSR), we designed and built up a new type of accelerator power supply prototype base on voltage-type space vector PWM (SVPWM) rectification technology. All the control strategies are developed in TMS320C28346, which is a digital signal processor from TI. The experimental results indicate that an accelerator power supply with a SVPWM rectifier can solve the problems above well, and the output performance such as stability, tracking error and ripple current meet the requirements of the design. The achievement of prototype confirms that applying voltage-type SVPWM rectification technology in an accelerator power supply is feasible; and it provides a good reference for design and build of this new type of power supply.

Preliminary Report on Mission Design and Operations for Critical Events

NASA Technical Reports Server (NTRS)

Hayden, Sandra C.; Tumer, Irem

2005-01-01

Mission-critical events are defined in the Jet Propulsion Laboratory s Flight Project Practices as those sequences of events which must succeed in order to attain mission goals. These are dependent on the particular operational concept and design reference mission, and are especially important when committing to irreversible events. Critical events include main engine cutoff (MECO) after launch; engine cutoff or parachute deployment on entry, descent, and landing (EDL); orbital insertion; separation of payload from vehicle or separation of booster segments; maintenance of pointing accuracy for power and communication; and deployment of solar arrays and communication antennas. The purpose of this paper is to report on the current practices in handling mission-critical events in design and operations at major NASA spaceflight centers. The scope of this report includes NASA Johnson Space Center (JSC), NASA Goddard Space Flight Center (GSFC), and NASA Jet Propulsion Laboratory (JPL), with staff at each center consulted on their current practices, processes, and procedures.

Identifying krill eggs in the central California current using novel multiplex PCR primers: Applications and limitations

NASA Astrophysics Data System (ADS)

Carrion, C. N.; Slesinger, E.; Marinovic, B.

2016-02-01

Euphausiids, otherwise known as krill, are an important link between primary producers and higher trophic levels within the central California current upwelling system. Euphausia pacifica and Thysanoessa spinifera, two of the most common euphausiid species along the central California coast, are both broadcast spawners and have some overlap in habitat, e.g. near marine life hotspots like the Monterey Bay and Gulf of Farallones. Species composition of euphausiid egg population within these regions is currently unknown. Distinct morphological differences between their eggs are lost once the egg dies or is preserved via formalin, alcohol, or freezing. In this project we designed genus specific DNA primers (mtCOI) for use in a multiplex PCR to distinguish among spawned euphausiid eggs of Euphausia spp. and Thysanoessa spp. in central California current surface waters. Effective and ineffective application of primers in a multiplex versus single-plex PCR is discussed, with an emphasis on primer design limitations in reference to the available barcoded regions of mitochondrial cytochrome oxidase subunit I (mtCOI) for each species in GenBank. This new protocol expands current monitoring efforts into sampling a non-swimming portion of the population which has the potential to improve euphausiid biomass estimates.

Definition of a 5MW/61.5m wind turbine blade reference model.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Resor, Brian Ray

2013-04-01

A basic structural concept of the blade design that is associated with the frequently utilized %E2%80%9CNREL offshore 5-MW baseline wind turbine%E2%80%9D is needed for studies involving blade structural design and blade structural design tools. The blade structural design documented in this report represents a concept that meets basic design criteria set forth by IEC standards for the onshore turbine. The design documented in this report is not a fully vetted blade design which is ready for manufacture. The intent of the structural concept described by this report is to provide a good starting point for more detailed and targeted investigationsmore » such as blade design optimization, blade design tool verification, blade materials and structures investigations, and blade design standards evaluation. This report documents the information used to create the current model as well as the analyses used to verify that the blade structural performance meets reasonable blade design criteria.« less

Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale.

PubMed

White, Helen E; Hedges, John; Bendit, Israel; Branford, Susan; Colomer, Dolors; Hochhaus, Andreas; Hughes, Timothy; Kamel-Reid, Suzanne; Kim, Dong-Wook; Modur, Vijay; Müller, Martin C; Pagnano, Katia B; Pane, Fabrizio; Radich, Jerry; Cross, Nicholas C P; Labourier, Emmanuel

2013-06-01

Current guidelines for managing Philadelphia-positive chronic myeloid leukemia include monitoring the expression of the BCR-ABL1 (breakpoint cluster region/c-abl oncogene 1, non-receptor tyrosine kinase) fusion gene by quantitative reverse-transcription PCR (RT-qPCR). Our goal was to establish and validate reference panels to mitigate the interlaboratory imprecision of quantitative BCR-ABL1 measurements and to facilitate global standardization on the international scale (IS). Four-level secondary reference panels were manufactured under controlled and validated processes with synthetic Armored RNA Quant molecules (Asuragen) calibrated to reference standards from the WHO and the NIST. Performance was evaluated in IS reference laboratories and with non-IS-standardized RT-qPCR methods. For most methods, percent ratios for BCR-ABL1 e13a2 and e14a2 relative to ABL1 or BCR were robust at 4 different levels and linear over 3 logarithms, from 10% to 0.01% on the IS. The intraassay and interassay imprecision was <2-fold overall. Performance was stable across 3 consecutive lots, in multiple laboratories, and over a period of 18 months to date. International field trials demonstrated the commutability of the reagents and their accurate alignment to the IS within the intra- and interlaboratory imprecision of IS-standardized methods. The synthetic calibrator panels are robust, reproducibly manufactured, analytically calibrated to the WHO primary standards, and compatible with most BCR-ABL1 RT-qPCR assay designs. The broad availability of secondary reference reagents will further facilitate interlaboratory comparative studies and independent quality assessment programs, which are of paramount importance for worldwide standardization of BCR-ABL1 monitoring results and the optimization of current and new therapeutic approaches for chronic myeloid leukemia. © 2013 American Association for Clinical Chemistry.

Construction of a pulse-coupled dipole network capable of fear-like and relief-like responses

NASA Astrophysics Data System (ADS)

Lungsi Sharma, B.

2016-07-01

The challenge for neuroscience as an interdisciplinary programme is the integration of ideas among the disciplines to achieve a common goal. This paper deals with the problem of deriving a pulse-coupled neural network that is capable of demonstrating behavioural responses (fear-like and relief-like). Current pulse-coupled neural networks are designed mostly for engineering applications, particularly image processing. The discovered neural network was constructed using the method of minimal anatomies approach. The behavioural response of a level-coded activity-based model was used as a reference. Although the spiking-based model and the activity-based model are of different scales, the use of model-reference principle means that the characteristics that is referenced is its functional properties. It is demonstrated that this strategy of dissection and systematic construction is effective in the functional design of pulse-coupled neural network system with nonlinear signalling. The differential equations for the elastic weights in the reference model are replicated in the pulse-coupled network geometrically. The network reflects a possible solution to the problem of punishment and avoidance. The network developed in this work is a new network topology for pulse-coupled neural networks. Therefore, the model-reference principle is a powerful tool in connecting neuroscience disciplines. The continuity of concepts and phenomena is further maintained by systematic construction using methods like the method of minimal anatomies.

Design and Performance Improvement of AC Machines Sharing a Common Stator

NASA Astrophysics Data System (ADS)

Guo, Lusu

With the increasing demand on electric motors in various industrial applications, especially electric powered vehicles (electric cars, more electric aircrafts and future electric ships and submarines), both synchronous reluctance machines (SynRMs) and interior permanent magnet (IPM) machines are recognized as good candidates for high performance variable speed applications. Developing a single stator design which can be used for both SynRM and IPM motors is a good way to reduce manufacturing and maintenance cost. SynRM can be used as a low cost solution for many electric driving applications and IPM machines can be used in power density crucial circumstances or work as generators to meet the increasing demand for electrical power on board. In this research, SynRM and IPM machines are designed sharing a common stator structure. The prototype motors are designed with the aid of finite element analysis (FEA). Machine performances with different stator slot and rotor pole numbers are compared by FEA. An 18-slot, 4-pole structure is selected based on the comparison for this prototype design. Sometimes, torque pulsation is the major drawback of permanent magnet synchronous machines. There are several sources of torque pulsations, such as back-EMF distortion, inductance variation and cogging torque due to presence of permanent magnets. To reduce torque pulsations in permanent magnet machines, all the efforts can be classified into two categories: one is from the design stage, the structure of permanent magnet machines can be optimized with the aid of finite element analysis. The other category of reducing torque pulsation is after the permanent magnet machine has been manufactured or the machine structure cannot be changed because of other reasons. The currents fed into the permanent magnet machine can be controlled to follow a certain profile which will make the machine generate a smoother torque waveform. Torque pulsation reduction methods in both categories will be discussed in this dissertation. In the design stage, an optimization method based on orthogonal experimental design will be introduced. Besides, a universal current profiling technique is proposed to minimize the torque pulsation along with the stator copper losses in modular interior permanent magnet motors. Instead of sinusoidal current waveforms, this algorithm will calculate the proper currents which can minimize the torque pulsation. Finite element analysis and Matlab programing will be used to develop this optimal current profiling algorithm. Permanent magnet machines are becoming more attractive in some modern traction applications, such as traction motors and generators for an electrified vehicle. The operating speed or the load condition in these applications may be changing all the time. Compared to electric machines used to operate at a constant speed and constant load, better control performance is required. In this dissertation, a novel model reference adaptive control (MRAC) used on five-phase interior permanent magnet motor drives is presented. The primary controller is designed based on artificial neural network (ANN) to simulate the nonlinear characteristics of the system without knowledge of accurate motor model or parameters. The proposed motor drive decouples the torque and flux components of five-phase IPM motors by applying a multiple reference frame transformation. Therefore, the motor can be easily driven below the rated speed with the maximum torque per ampere (MTPA) operation or above the rated speed with the flux weakening operation. The ANN based primary controller consists of a radial basis function (RBF) network which is trained on-line to adapt system uncertainties. The complete IPM motor drive is simulated in Matlab/Simulink environment and implemented experimentally utilizing dSPACE DS1104 DSP board on a five-phase prototype IPM motor. The proposed model reference adaptive control method has been applied on the commons stator SynRM and IPM machine as well.

Predicting fertility.

PubMed

Maheshwari, Abha; Bhattacharya, Siladitya; Johnson, Neil P

2008-06-01

Various predictors of fertility have been described, suggesting that none are ideal. The literature on tests of ovarian reserve is largely limited to women undergoing in vitro fertilization, and is reliant on the use of surrogate markers, such as cycle cancellation and number of oocytes retrieved, as reference standards. Currently available prediction models are far from ideal; most are applicable only to subfertile women seeking assisted reproduction, and lack external validation. Systematic reviews and meta-analyses of predictors of fertility are limited by their heterogeneity in terms of the population sampled, predictors tested and reference standards used. There is an urgent need for consensus in the design of these studies, definition of abnormal tests, and, above all, a need to use robust outcomes such as live birth as the reference standard. There are no reliable predictors of fertility that can guide women as to how long childbearing can be deferred.

Phase change references for in-flight recalibration of orbital thermometry

NASA Astrophysics Data System (ADS)

Topham, T. S.; Latvakoski, H.; Watson, M.

2013-09-01

Several critical questions need to be answered to determine the potential utility of phase change materials as long-term orbital references: How accurate and repeatable will phase change reference implementations be after incorporating necessary design trade-offs to accommodate launch and the space environment? How can the temperature of phase transitions be transferred to something useful for calibration such as a black body. How, if at all, will the microgravity environment affect the phase transitions? To help answer some of these questions, three experiments will be conducted on the International Space Station (ISS). The experiments will test melts and freezes of three different phase change materials in various containment apparatus. This paper addresses the current status of the ISS experiments, as well as results from ground testing of several concepts for space application of PCM recalibration systems in the CORSAIR (Calibration Observations of Radiance Spectra in the far Infrared) black body.

Decision making about healthcare-related tests and diagnostic test strategies. Paper 2: a review of methodological and practical challenges.

PubMed

Mustafa, Reem A; Wiercioch, Wojtek; Cheung, Adrienne; Prediger, Barbara; Brozek, Jan; Bossuyt, Patrick; Garg, Amit X; Lelgemann, Monika; Büehler, Diedrich; Schünemann, Holger J

2017-12-01

In this first of a series of five articles, we provide an overview of how and why healthcare-related tests and diagnostic strategies are currently applied. We also describe how our findings can be integrated with existing frameworks for making decisions that guide the use of healthcare-related tests and diagnostic strategies. We searched MEDLINE, references of identified articles, chapters in relevant textbooks, and identified articles citing classic literature on this topic. We provide updated frameworks for the potential roles and applications of tests with suggested definitions and practical examples. We also discuss study designs that are commonly used to assess tests' performance and the effects of tests on people's health. These designs include diagnostic randomized controlled trials and retrospective validation. We describe the utility of these and other currently suggested designs, which questions they can answer and which ones they cannot. In addition, we summarize the challenges unique to decision-making resulting from the use of tests. This overview highlights current challenges in the application of tests in decision-making in healthcare, provides clarifications, and informs the proposed solutions. Copyright © 2017 Elsevier Inc. All rights reserved.

Application of Recommended Design Practices for Conceptual Nuclear Fusion Space Propulsion Systems

NASA Technical Reports Server (NTRS)

Williams, Craig H.

2004-01-01

An AIAA Special Project Report was recently produced by AIAA's Nuclear and Future Flight Propulsion Technical Committee and is currently in peer review. The Report provides recommended design practices for conceptual engineering studies of nuclear fusion space propulsion systems. Discussion and recommendations are made on key topics including design reference missions, degree of technological extrapolation and concomitant risk, thoroughness in calculating mass properties (nominal mass properties, weight-growth contingency and propellant margins, and specific impulse), and thoroughness in calculating power generation and usage (power-flow, power contingencies, specific power). The report represents a general consensus of the nuclear fusion space propulsion system conceptual design community and proposes 15 recommendations. This paper expands on the Report by providing specific examples illustrating how to apply each of the recommendations.

76 FR 7245 - Endangered and Threatened Wildlife and Plants; Revised Critical Habitat for the Arroyo Toad

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

...We, the U.S. Fish and Wildlife Service (Service), are designating final revised critical habitat for the arroyo toad (Anaxyrus californicus, Bufo californicus). We are designating approximately 98,366 acres (ac) (39,807 hectares (ha)) of habitat in Santa Barbara, Ventura, Los Angeles, San Bernardino, Riverside, Orange, and San Diego Counties, California, as critical habitat for the arroyo toad. This final revised designation constitutes an increase of approximately 86,671 ac (35,074 ha) from the 2005 designation of critical habitat for the arroyo toad. A taxonomic name change has occurred and been accepted for the arroyo toad. Throughout the remainder of this document we will use the currently recognized name for the listed entity, Anaxyrus californicus, for references to the arroyo toad.

Study directed at development of an implantable biotelemetry ion detector

NASA Technical Reports Server (NTRS)

Hanley, L. D.; Kress, D.

1971-01-01

A literature search was conducted to currently update known information in the field of ion-selective electrodes. The review attempts to identify present trends in cation and anions selective electrodes pertinent to the area of bioimplantable units. An electronic circuit was designed to provide the high impedance interface between the ion-selective sensors and signal-processing equipment. The resulting design emphasized the need for low power and miniaturization. Many of the circuits were constructed and used to evaluate the ion-selective electrodes. A cuvette capable of holding the ion-selective and the reference electrodes was designed and constructed. This equipment was used to evaluate commercially available ion-selective electrodes and the electrodes designed and constructed in the study. The results of the electrode tests are included.

Design concept of K-DEMO for near-term implementation

NASA Astrophysics Data System (ADS)

Kim, K.; Im, K.; Kim, H. C.; Oh, S.; Park, J. S.; Kwon, S.; Lee, Y. S.; Yeom, J. H.; Lee, C.; Lee, G.-S.; Neilson, G.; Kessel, C.; Brown, T.; Titus, P.; Mikkelsen, D.; Zhai, Y.

2015-05-01

A Korean fusion energy development promotion law (FEDPL) was enacted in 2007. As a following step, a conceptual design study for a steady-state Korean fusion demonstration reactor (K-DEMO) was initiated in 2012. After the thorough 0D system analysis, the parameters of the main machine characterized by the major and minor radii of 6.8 and 2.1 m, respectively, were chosen for further study. The analyses of heating and current drives were performed for the development of the plasma operation scenarios. Preliminary results on lower hybrid and neutral beam current drive are included herein. A high performance Nb3Sn-based superconducting conductor is adopted, providing a peak magnetic field approaching 16 T with the magnetic field at the plasma centre above 7 T. Pressurized water is the prominent choice for the main coolant of K-DEMO when the balance of plant development details is considered. The blanket system adopts a ceramic pebble type breeder. Considering plasma performance, a double-null divertor is the reference configuration choice of K-DEMO. For a high availability operation, K-DEMO incorporates a design with vertical maintenance. A design concept for K-DEMO is presented together with the preliminary design parameters.

Single phase inverter for a three phase power generation and distribution system

NASA Technical Reports Server (NTRS)

Lindena, S. J.

1976-01-01

A breadboard design of a single-phase inverter with sinusoidal output voltage for a three-phase power generation and distribution system was developed. The three-phase system consists of three single-phase inverters, whose output voltages are connected in a delta configuration. Upon failure of one inverter the two remaining inverters will continue to deliver three-phase power. Parallel redundancy as offered by two three-phase inverters is substituted by one three-phase inverter assembly with high savings in volume, weight, components count and complexity, and a considerable increase in reliability. The following requirements must be met: (1) Each single-phase, current-fed inverter must be capable of being synchronized to a three-phase reference system such that its output voltage remains phaselocked to its respective reference voltage. (2) Each single-phase, current-fed inverter must be capable of accepting leading and lagging power factors over a range from -0.7 through 1 to +0.7.

Development of dual PZT transducers for reference-free crack detection in thin plate structures.

PubMed

Sohn, Hoon; Kim, Seuno Bum

2010-01-01

A new Lamb-wave-based nondestructive testing (NDT) technique, which does not rely on previously stored baseline data, is developed for crack monitoring in plate structures. Commonly, the presence of damage is identified by comparing "current data" measured from a potentially damaged stage of a structure with "baseline data" previously obtained at the intact condition of the structure. In practice, structural defects typically take place long after collection of the baseline data, and the baseline data can be also affected by external loading, temperature variations, and changing boundary conditions. To eliminate the dependence on the baseline data comparison, the authors previously developed a reference-free NDT technique using 2 pairs of collocated lead zirconate titanate (PZT) transducers placed on both sides of a plate. This reference-free technique is further advanced in the present study by the necessity of attaching transducers only on a single surface of a structure for certain applications such as aircraft. To achieve this goal, a new design of PZT transducers called dual PZT transducers is proposed. Crack formation creates Lamb wave mode conversion due to a sudden thickness change of the structure. This crack appearance is instantly detected from the measured Lamb wave signals using the dual PZT transducers. This study also suggests a reference-free statistical approach that enables damage classification using only the currently measured data set. Numerical simulations and experiments were conducted using an aluminum plate with uniform thickness and fundamental Lamb waves modes to demonstrate the applicability of the proposed technique to reference-free crack detection.

Device for monitoring cell voltage

DOEpatents

Doepke, Matthias [Garbsen, DE; Eisermann, Henning [Edermissen, DE

2012-08-21

A device for monitoring a rechargeable battery having a number of electrically connected cells includes at least one current interruption switch for interrupting current flowing through at least one associated cell and a plurality of monitoring units for detecting cell voltage. Each monitoring unit is associated with a single cell and includes a reference voltage unit for producing a defined reference threshold voltage and a voltage comparison unit for comparing the reference threshold voltage with a partial cell voltage of the associated cell. The reference voltage unit is electrically supplied from the cell voltage of the associated cell. The voltage comparison unit is coupled to the at least one current interruption switch for interrupting the current of at least the current flowing through the associated cell, with a defined minimum difference between the reference threshold voltage and the partial cell voltage.

A low-voltage sense amplifier with two-stage operational amplifier clamping for flash memory

NASA Astrophysics Data System (ADS)

Guo, Jiarong

2017-04-01

A low-voltage sense amplifier with reference current generator utilizing two-stage operational amplifier clamp structure for flash memory is presented in this paper, capable of operating with minimum supply voltage at 1 V. A new reference current generation circuit composed of a reference cell and a two-stage operational amplifier clamping the drain pole of the reference cell is used to generate the reference current, which avoids the threshold limitation caused by current mirror transistor in the traditional sense amplifier. A novel reference voltage generation circuit using dummy bit-line structure without pull-down current is also adopted, which not only improves the sense window enhancing read precision but also saves power consumption. The sense amplifier was implemented in a flash realized in 90 nm flash technology. Experimental results show the access time is 14.7 ns with power supply of 1.2 V and slow corner at 125 °C. Project supported by the National Natural Science Fundation of China (No. 61376028).

ME 5620 Fracture Mechanics in Engineering Design. Case Study Project

DTIC Science & Technology

2011-04-03

14 UNCLASSIFIED References 1 . A First Course in the Finite Element Method, 4th edition, by D.L. Logan, Thomson Engineering, 2006. 2. Altair ...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources...currently valid OMB control number. 1 . REPORT DATE 03 APR 2011 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Case Study

What Should Be the Policy of the United States Government toward the People's Republic of China. National Debate Topic for High Schools, 1995-96. 104th Congress, 1st Session.

ERIC Educational Resources Information Center

Library of Congress, Washington, DC. Congressional Research Service.

Sampling the wide spectrum of opinions reflected in the current literature on the topic, this book presents a compilation of materials and bibliographic references designed to assist high school debaters in researching the topic of whether the United States government should substantially change its policy (foreign and economic) toward the…

Solar satellites

NASA Astrophysics Data System (ADS)

Poher, C.

A reference system design, projected costs, and the functional concepts of a satellite solar power system (SSPS) for converting sunlight falling on solar panels of a satellite in GEO to a multi-GW beam which could be received by a rectenna on earth are outlined. Electricity transmission by microwaves has been demonstrated, and a reference design system for supplying 5 GW dc to earth was devised. The system will use either monocrystalline Si or concentrator GaAs solar cells for energy collection in GEO. Development is still needed to improve the lifespan of the cells. Currently, the cell performance degrades 50 percent in efficiency after 7-8 yr in space. Each SSPS satellite would weigh either 34,000 tons (Si) or 51,000 tons (GaAs), thereby requiring the fabrication of a heavy lift launch vehicle or a single-stage-to-orbit transport in order to minimize launch costs. Costs for the solar panels have been estimated at $500/kW using the GaAs technology, with transport costs for materials to GEO being $40/kg.

A systematic review of current and emergent manipulator control approaches

NASA Astrophysics Data System (ADS)

Ajwad, Syed Ali; Iqbal, Jamshed; Ullah, Muhammad Imran; Mehmood, Adeel

2015-06-01

Pressing demands of productivity and accuracy in today's robotic applications have highlighted an urge to replace classical control strategies with their modern control counterparts. This recent trend is further justified by the fact that the robotic manipulators have complex nonlinear dynamic structure with uncertain parameters. Highlighting the authors' research achievements in the domain of manipulator design and control, this paper presents a systematic and comprehensive review of the state-of-the-art control techniques that find enormous potential in controlling manipulators to execute cuttingedge applications. In particular, three kinds of strategies, i.e., intelligent proportional-integral-derivative (PID) scheme, robust control and adaptation based approaches, are reviewed. Future trend in the subject area is commented. Open-source simulators to facilitate controller design are also tabulated. With a comprehensive list of references, it is anticipated that the review will act as a firsthand reference for researchers, engineers and industrialinterns to realize the control laws for multi-degree of freedom (DOF) manipulators.

State of the NASA Aeropropulsion Discipline Input from the Glenn Research Center

NASA Technical Reports Server (NTRS)

Reddy, D. R.; Schmidt, George

2017-01-01

PROBLEM: Current power turbines are designed for single operating speed, and performance degrades rapidly as power turbine speed decreases. OBJECTIVES: Demonstrate 50 improvement in efficient operational capability using a Variable Speed Power Turbine concept. (Refer to figure lower left, where the goal is to raise efficiency from the current technology line to the green line which represents the AVSPOT VSPT goal.APPROACH: Conduct RD required to advance the technology readiness level of VSPT technology to TRL 4Partner with DoD and leverage DOD AVSPOT contract to share government cost (5050) of contracted efforts to GE and PW for VSPT TRL 45 demonstration.

Electrical safety Q&A. A reference guide for the clinical engineer.

PubMed

2005-02-01

This guide, which ECRI developed to answer the electrical safety questions most frequently asked by member hospitals, features practical advice for addressing electrical safety concerns in the healthcare environment. Questions addressed include: STANDARDS AND APPROVALS: What electrical safety standards apply? How do NFPA 99 and IEC 60601-1 differ? What organizations approve medical devices? LEAKAGE CURRENT LIMITS AND TESTING: How are leakage current limits established? What limits apply to equipment used in the hospital? And how should the limits be applied in special cases, such as the use of PCs in the patient care area or equipment used in the clinical laboratory? ISOLATED POWER: What are its advantages and disadvantages, and is isolated power needed in the operating room? Other topics addressed include double insulation, ground-fault circuit interrupters (GFCIs), and requirements for medical devices used in the home. Supplementary articles discuss acceptable alternatives to UL listing, the use of Hospital Grade plugs, the limitations of leakage current testing of devices connected to isolated power systems, and the debate about whether to designate ORs as wet locations. Experienced clinical engineers should find this guide to be a handy reference, while those new to the field should find it to be a helpful educational resource.

A noninterference blade vibration measurement system for gas turbine engines

NASA Astrophysics Data System (ADS)

Watkins, William B.; Chi, Ray M.

1987-06-01

A noninterfering blade vibration system has been demonstrated in tests of a gas turbine first stage fan. Conceptual design of the system, including its theory, design of case mounted probes, and data acquisition and signal processing hardware was done in a previous effort. The current effort involved instrumentation of an engine fan stage with strain gages; data acquisition using shaft-mounted reference and case-mounted optical probes; recording of data on a wideband tape recorder; and posttest processing using off-line analysis in a facility computer and a minicomputer-based readout system designed for near- real-time readout. Results are presented in terms of true blade vibration frequencies, time and frequency dependent vibration amplitudes and comparison of the optical noninterference results with strain gage readings.

In-Flight Manual Electronics Repair for Deep-Space Missions

NASA Technical Reports Server (NTRS)

Pettegrew, Richard; Easton, John; Struk, Peter; Anderson, Eric

2007-01-01

Severe limitations on mass and volume available for spares on long-duration spaceflight missions will require electronics repair to be conducted at the component level, rather than at the sub-assembly level (referred to as Orbital Replacement Unit, or 'ORU'), as is currently the case aboard the International Space Station. Performing reliable component-level repairs in a reduced gravity environment by crew members will require careful planning, and some specialty tools and systems. Additionally, spacecraft systems must be designed to enable such repairs. This paper is an overview of a NASA project which examines all of these aspects of component level electronic repair. Results of case studies that detail how NASA, the U.S. Navy, and a commercial company currently approach electronics repair are presented, along with results of a trade study examining commercial technologies and solutions which may be used in future applications. Initial design recommendations resulting from these studies are also presented.

A nonlinear control scheme based on dynamic evolution path theory for improved dynamic performance of boost PFC converter working on nonlinear features.

PubMed

Mohanty, Pratap Ranjan; Panda, Anup Kumar

2016-11-01

This paper is concerned to performance improvement of boost PFC converter under large random load fluctuation, ensuring unity power factor (UPF) at source end and regulated voltage at load side. To obtain such performance, a nonlinear controller based on dynamic evolution path theory is designed and its robustness is examined under both heavy and light loading condition. In this paper, %THD and zero-cross-over dead-zone of input current is significantly reduced. Also, very less response time of input current and output voltage to that of load and reference variation is remarked. A simulation model of proposed system is designed and it is realized using dSPACE 1104 signal processor for a 390V DC , 500W prototype. The relevant experimental and simulation waveforms are presented. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

The Global Geodetic Observing System: Space Geodesy Networks for the Future

NASA Technical Reports Server (NTRS)

Pearlman, Michael; Pavlis, Erricos; Ma, Chopo; Altamini, Zuheir; Noll, Carey; Stowers, David

2011-01-01

Ground-based networks of co-located space geodetic techniques (VLBI, SLR, GNSS. and DORIS) are the basis for the development and maintenance of the International Terrestrial Reference frame (ITRF), which is our metric of reference for measurements of global change, The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG) has established a task to develop a strategy to design, integrate and maintain the fundamental geodetic network and supporting infrastructure in a sustainable way to satisfy the long-term requirements for the reference frame. The GGOS goal is an origin definition at 1 mm or better and a temporal stability on the order of 0.1 mm/y, with similar numbers for the scale and orientation components. These goals are based on scientific requirements to address sea level rise with confidence, but other applications are not far behind. Recent studies including one by the US National Research Council has strongly stated the need and the urgency for the fundamental space geodesy network. Simulations are underway to examining accuracies for origin, scale and orientation of the resulting ITRF based on various network designs and system performance to determine the optimal global network to achieve this goal. To date these simulations indicate that 24 - 32 co-located stations are adequate to define the reference frame and a more dense GNSS and DORIS network will be required to distribute the reference frame to users anywhere on Earth. Stations in the new global network will require geologically stable sites with good weather, established infrastructure, and local support and personnel. GGOS wil seek groups that are interested in participation. GGOS intends to issues a Call for Participation of groups that would like to contribute in the network implementation and operation. Some examples of integrated stations currently in operation or under development will be presented. We will examine necessary conditions and challenges in designing a co-location station.

Mars Surface Mission Workshop

NASA Technical Reports Server (NTRS)

Duke, M. B. (Editor)

1997-01-01

A workshop was held at the Lunar and Planetary Institute on September 4-5, 1997, to address the surface elements of the Mars Reference Mission now being reviewed by NASA. The workshop considered the current reference mission and addressed the types of activities that would be expected for science and resource exploration and facilities operations. A set of activities was defined that can be used to construct "vignettes" of the surface mission. These vignettes can form the basis for describing the importance of the surface mission, for illustrating aspects of the surface mission, and for allowing others to extend and revise these initial ideas. The topic is rich with opportunities for additional conceptualization. It is recommended that NASA consider supporting university design teams to conduct further analysis of the possibilities.

Simultaneous tracking and regulation visual servoing of wheeled mobile robots with uncalibrated extrinsic parameters

NASA Astrophysics Data System (ADS)

Lu, Qun; Yu, Li; Zhang, Dan; Zhang, Xuebo

2018-01-01

This paper presentsa global adaptive controller that simultaneously solves tracking and regulation for wheeled mobile robots with unknown depth and uncalibrated camera-to-robot extrinsic parameters. The rotational angle and the scaled translation between the current camera frame and the reference camera frame, as well as the ones between the desired camera frame and the reference camera frame can be calculated in real time by using the pose estimation techniques. A transformed system is first obtained, for which an adaptive controller is then designed to accomplish both tracking and regulation tasks, and the controller synthesis is based on Lyapunov's direct method. Finally, the effectiveness of the proposed method is illustrated by a simulation study.

New insights on SOI Tunnel FETs with low-temperature process flow for CoolCube™ integration

NASA Astrophysics Data System (ADS)

Diaz Llorente, C.; Le Royer, C.; Batude, P.; Fenouillet-Beranger, C.; Martinie, S.; Lu, C.-M. V.; Allain, F.; Colinge, J.-P.; Cristoloveanu, S.; Ghibaudo, G.; Vinet, M.

2018-06-01

This paper reports the fabrication and electrical characterization of planar SOI Tunnel FETs (TFETs) made using a Low-Temperature (LT) process designed for 3D sequential integration. These proof-of-concept TFETs feature junctions obtained by Solid Phase Epitaxy Regrowth (SPER). Their electrical behavior is analyzed and compared to reference samples (regular process using High-Temperature junction formation, HT). Dual ID-VDS measurements verify that the TFET structures present Band-to-Band tunnelling (BTBT) carrier injection and not Schottky Barrier tunnelling. P-mode operating LT TFETs deliver an ON state current similar to that of the HT reference, opening the door towards optimized devices operating with very low threshold voltage VTH and low supply voltage VDD.

Synthetic biology through biomolecular design and engineering.

PubMed

Channon, Kevin; Bromley, Elizabeth H C; Woolfson, Derek N

2008-08-01

Synthetic biology is a rapidly growing field that has emerged in a global, multidisciplinary effort among biologists, chemists, engineers, physicists, and mathematicians. Broadly, the field has two complementary goals: To improve understanding of biological systems through mimicry and to produce bio-orthogonal systems with new functions. Here we review the area specifically with reference to the concept of synthetic biology space, that is, a hierarchy of components for, and approaches to generating new synthetic and functional systems to test, advance, and apply our understanding of biological systems. In keeping with this issue of Current Opinion in Structural Biology, we focus largely on the design and engineering of biomolecule-based components and systems.

Design and realization of the compound text-based test questions library management system

NASA Astrophysics Data System (ADS)

Shi, Lei; Feng, Lin; Zhao, Xin

2011-12-01

The test questions library management system is the essential part of the on-line examination system. The basic demand for which is to deal with compound text including information like images, formulae and create the corresponding Word documents. Having compared with the two current solutions of creating documents, this paper presents a design proposal of Word Automation mechanism based on OLE/COM technology, and discusses the way of Word Automation application in detail and at last provides the operating results of the system which have high reference value in improving the generated efficiency of project documents and report forms.

In-Space Transportation for GEO Space Solar Power Satellites

NASA Technical Reports Server (NTRS)

Martin, James A.; Donnahue, Benjamin B.; Henley, Mark W.

1999-01-01

This report summarizes results of study tasks to evaluate design options for in-space transportation of geostationary Space Solar Power Satellites. Referring to the end-to-end architecture studies performed in 1988, this current activity focuses on transportation of Sun Tower satellite segments from an initial low Earth orbit altitude to a final position in geostationary orbit (GEO; i.e., 35,786 km altitude, circular, equatorial orbit). This report encompasses study activity for In-Space Transportation of GEO Space Solar Power (SSP) Satellites including: 1) assessment of requirements, 2) design of system concepts, 3) comparison of alternative system options, and 4) assessment of potential derivatives.

Design and performance of a large area neutron sensitive anger camera

DOE PAGES

Visscher, Theodore; Montcalm, Christopher A.; Donahue, Jr., Cornelius; ...

2015-05-21

We describe the design and performance of a 157mm x 157mm two dimensional neutron detector. The detector uses the Anger principle to determine the position of neutrons. We have verified FWHM resolution of < 1.2mm with distortion < 0.5mm on over 50 installed Anger Cameras. The performance of the detector is limited by the light yield of the scintillator, and it is estimated that the resolution of the current detector could be doubled with a brighter scintillator. Data collected from small (<1mm 3) single crystal reference samples at the single crystal instrument TOPAZ provide results with low R w(F) values

Collaborative studies on the development of national reference standards for potency determination of H7N9 influenza vaccine

PubMed Central

Li, Changgui; Xu, Kangwei; Hashem, Anwar; Shao, Ming; Liu, Shuzhen; Zou, Yong; Gao, Qiang; Zhang, Yongchao; Yuan, Liyong; Xu, Miao; Li, Xuguang; Wang, Junzhi

2015-01-01

The outbreak of human infections of a novel avian influenza virus A (H7N9) prompted the development of the vaccines against this virus. Like all types of influenza vaccines, H7N9 vaccine must be tested for its potency prior to being used in humans. However, the unavailability of international reference reagents for the potency determination of H7N9 vaccines substantially hinders the progress in vaccine development. To facilitate clinical development, we enlisted 5 participants in a collaborative study to develop critical reagents used in Single Radial Immunodiffusion (SRID), the currently acceptable assay for potency determination of influenza vaccine. Specifically, the hemagglutinin (HA) content of one vaccine bulk for influenza A (H7N9), herein designated as Primary Liquid Standard (PLS), was determined by SDS-PAGE. In addition, the freeze-dried antigen references derived from PLS were prepared to enhance the stability for long term storage. The final HA content of lyophilized antigen references were calibrated against PLS by SRID assay in a collaborative study. Importantly, application of these national reference standards to potency analyses greatly facilitated the development of H7N9 vaccines in China. PMID:25970793

System and method for charging electrochemical cells in series

DOEpatents

DeLuca, William H.; Hornstra, Jr, Fred; Gelb, George H.; Berman, Baruch; Moede, Larry W.

1980-01-01

A battery charging system capable of equalizing the charge of each individual cell at a selected full charge voltage includes means for regulating charger current to first increase current at a constant rate until a bulk charging level is achieved or until any cell reaches a safe reference voltage. A system controller then begins to decrease the charging rate as long as any cell exceeds the reference voltage until an equalization current level is reached. At this point, the system controller activates a plurality of shunt modules to permit shunting of current around any cell having a voltage exceeding the reference voltage. Leads extending between the battery of cells and shunt modules are time shared to permit alternate shunting of current and voltage monitoring without the voltage drop caused by the shunt current. After each cell has at one time exceeded the reference voltage, the charging current is terminated.

Toward the holistic, reference, and extendable atlas of the human brain, head, and neck.

PubMed

Nowinski, Wieslaw L

2015-06-01

Despite numerous efforts, a fairly complete (holistic) anatomical model of the whole, normal, adult human brain, which is required as the reference in brain studies and clinical applications, has not yet been constructed. Our ultimate objective is to build this kind of atlas from advanced in vivo imaging. This work presents the taxonomy of our currently developed brain atlases and addresses the design, content, functionality, and current results in the holistic atlas development as well as atlas usefulness and future directions. We have developed to date 35 commercial brain atlases (along with numerous research prototypes), licensed to 63 companies and institutions, and made available to medical societies, organizations, medical schools, and individuals. These atlases have been applied in education, research, and clinical applications. Hundreds of thousands of patients have been treated by using our atlases. Based on this experience, the first version of the holistic and reference atlas of the brain, head, and neck has been developed and made available. The atlas has been created from multispectral 3 and 7 Tesla and high-resolution CT in vivo scans. It is fully 3D, scalable, interactive, and highly detailed with about 3,000 labeled components. This atlas forms a foundation for the development of a multi-level molecular, cellular, anatomical, physiological, and behavioral brain atlas platform.

Self-Regulatory Capacities Are Depleted in a Domain-Specific Manner

PubMed Central

Zhang, Rui; Stock, Ann-Kathrin; Rzepus, Anneka; Beste, Christian

2017-01-01

Performing an act of self-regulation such as making decisions has been suggested to deplete a common limited resource, which impairs all subsequent self-regulatory actions (ego depletion theory). It has however remained unclear whether self-referred decisions truly impair behavioral control even in seemingly unrelated cognitive domains, and which neurophysiological mechanisms are affected by these potential depletion effects. In the current study, we therefore used an inter-individual design to compare two kinds of depletion, namely a self-referred choice-based depletion and a categorization-based switching depletion, to a non-depleted control group. We used a backward inhibition (BI) paradigm to assess the effects of depletion on task switching and associated inhibition processes. It was combined with EEG and source localization techniques to assess both behavioral and neurophysiological depletion effects. The results challenge the ego depletion theory in its current form: Opposing the theory’s prediction of a general limited resource, which should have yielded comparable effects in both depletion groups, or maybe even a larger depletion in the self-referred choice group, there were stronger performance impairments following a task domain-specific depletion (i.e., the switching-based depletion) than following a depletion based on self-referred choices. This suggests at least partly separate and independent resources for various cognitive control processes rather than just one joint resource for all self-regulation activities. The implications are crucial to consider for people making frequent far-reaching decisions e.g., in law or economy. PMID:29033798

Self-Regulatory Capacities Are Depleted in a Domain-Specific Manner.

PubMed

Zhang, Rui; Stock, Ann-Kathrin; Rzepus, Anneka; Beste, Christian

2017-01-01

Performing an act of self-regulation such as making decisions has been suggested to deplete a common limited resource, which impairs all subsequent self-regulatory actions (ego depletion theory). It has however remained unclear whether self-referred decisions truly impair behavioral control even in seemingly unrelated cognitive domains, and which neurophysiological mechanisms are affected by these potential depletion effects. In the current study, we therefore used an inter-individual design to compare two kinds of depletion, namely a self-referred choice-based depletion and a categorization-based switching depletion, to a non-depleted control group. We used a backward inhibition (BI) paradigm to assess the effects of depletion on task switching and associated inhibition processes. It was combined with EEG and source localization techniques to assess both behavioral and neurophysiological depletion effects. The results challenge the ego depletion theory in its current form: Opposing the theory's prediction of a general limited resource, which should have yielded comparable effects in both depletion groups, or maybe even a larger depletion in the self-referred choice group, there were stronger performance impairments following a task domain-specific depletion (i.e., the switching-based depletion) than following a depletion based on self-referred choices. This suggests at least partly separate and independent resources for various cognitive control processes rather than just one joint resource for all self-regulation activities. The implications are crucial to consider for people making frequent far-reaching decisions e.g., in law or economy.

Comparison of current ATDs with Chinese adults in anthropometry.

PubMed

Cao, Libo; Zhang, Kai; Lv, Xin; Yan, Lingbo

2016-05-18

Crash test dummies are full-scale anthropomorphic test devices (ATDs) that simulate the dimensions, weight proportions, and articulation of the human body and are used to measure human injury potential in vehicle crashes. The Hybrid III dummy family, which is widely used currently, takes selected percentiles of anthropometry dimensions of U.S. adults as design references. The objective of this study was to assess the difference in anthropometry between Chinese adults and the currently used dummy. Based on the Chinese National Physical Fitness Surveillance of the year 2000, 2005, 2010 and National Standard of China GB/T 10000-1988, a series of anthropometric parameters for Chinese adults were obtained, and data analysis was conducted between Chinese adults and ATDs that are currently used. The comparison revealed distinct anthropometric difference between ATDs and Chinese adults. Based on the latest data, median Chinese females were about 2.6% lower in stature and about 8.03% lower in body weight than the ATD design targets. Similarly, median Chinese males were about 3.48% shorter and weighed 11.89% less than the ATD design targets. Although the anthropometric differences between Chinese adults and the Hybrid III ATD specifications were modest and growing smaller, it is advisable to take the differences in anthropometry between ATDs and Chinese adults into consideration when developing new vehicles in China to provide effective protection specifically for Chinese occupants.

Characterization and Uncertainty Analysis of a Reference Pressure Measurement System for Wind Tunnels

NASA Technical Reports Server (NTRS)

Amer, Tahani; Tripp, John; Tcheng, Ping; Burkett, Cecil; Sealey, Bradley

2004-01-01

This paper presents the calibration results and uncertainty analysis of a high-precision reference pressure measurement system currently used in wind tunnels at the NASA Langley Research Center (LaRC). Sensors, calibration standards, and measurement instruments are subject to errors due to aging, drift with time, environment effects, transportation, the mathematical model, the calibration experimental design, and other factors. Errors occur at every link in the chain of measurements and data reduction from the sensor to the final computed results. At each link of the chain, bias and precision uncertainties must be separately estimated for facility use, and are combined to produce overall calibration and prediction confidence intervals for the instrument, typically at a 95% confidence level. The uncertainty analysis and calibration experimental designs used herein, based on techniques developed at LaRC, employ replicated experimental designs for efficiency, separate estimation of bias and precision uncertainties, and detection of significant parameter drift with time. Final results, including calibration confidence intervals and prediction intervals given as functions of the applied inputs, not as a fixed percentage of the full-scale value are presented. System uncertainties are propagated beginning with the initial reference pressure standard, to the calibrated instrument as a working standard in the facility. Among the several parameters that can affect the overall results are operating temperature, atmospheric pressure, humidity, and facility vibration. Effects of factors such as initial zeroing and temperature are investigated. The effects of the identified parameters on system performance and accuracy are discussed.

Flexible Educational Facilities. An Annotated Reference List.

ERIC Educational Resources Information Center

Wakefield, Howard E.

These references on flexible educational facilities are abstracted by the ERIC Clearinghouse on Educational Facilities. College material includes an experimental learning center, a college health center, a fine arts center, and university library design. References on schools include secondary school design, flexible high school design, standard…

It's time to reinvent the general aviation airplane

NASA Technical Reports Server (NTRS)

Stengel, Robert F.

1988-01-01

Current designs for general aviation airplanes have become obsolete, and avenues for major redesign must be considered. New designs should incorporate recent advances in electronics, aerodynamics, structures, materials, and propulsion. Future airplanes should be optimized to operate satisfactorily in a positive air traffic control environment, to afford safety and comfort for point-to-point transportation, and to take advantage of automated manufacturing techniques and high production rates. These requirements have broad implications for airplane design and flying qualities, leading to a concept for the Modern Equipment General Aviation (MEGA) airplane. Synergistic improvements in design, production, and operation can provide a much needed fresh start for the general aviation industry and the traveling public. In this investigation a small four place airplane is taken as the reference, although the proposed philosophy applies across the entire spectrum of general aviation.

Precision Voltage Referencing Techniques in MOS Technology.

NASA Astrophysics Data System (ADS)

Song, Bang-Sup

With the increasing complexity of functions on a single MOS chip, precision analog cicuits implemented in the same technology are in great demand so as to be integrated together with digital circuits. The future development of MOS data acquisition systems will require precision on-chip MOS voltage references. This dissertation will probe two most promising configurations of on-chip voltage references both in NMOS and CMOS technologies. In NMOS, an ion-implantation effect on the temperature behavior of MOS devices is investigated to identify the fundamental limiting factors of a threshold voltage difference as an NMOS voltage source. For this kind of voltage reference, the temperature stability on the order of 20ppm/(DEGREES)C is achievable with a shallow single-threshold implant and a low-current, high-body bias operation. In CMOS, a monolithic prototype bandgap reference is designed, fabricated and tested which embodies a curvature compensation and exhibits a minimized sensitivity to the process parameter variation. Experimental results imply that an average temperature stability on the order of 10ppm/(DEGREES)C with a production spread of less than 10ppm/(DEGREES)C feasible over the commercial temperature range.

Preliminary results from fatigue tests with reference to operational statistics

NASA Technical Reports Server (NTRS)

Gassner, E

1950-01-01

Simple elements were subjected to repeated loads of variable ampliture, chosen in such a way that they may be regarded as approximations to the operational loads (gust and maneuver) experienced by an airplane. The effect of varying some parameters was investigated briefly. Some discussion is given of the question whether a design according to current (1938 German) requirements for static strength is adequate from the fatigue point of view, and existing requirements on fatigue strength are compared,

Using Third Party Data to Update a Reference Dataset in a Quality Evaluation Service

NASA Astrophysics Data System (ADS)

Xavier, E. M. A.; Ariza-López, F. J.; Ureña-Cámara, M. A.

2016-06-01

Nowadays it is easy to find many data sources for various regions around the globe. In this 'data overload' scenario there are few, if any, information available about the quality of these data sources. In order to easily provide these data quality information we presented the architecture of a web service for the automation of quality control of spatial datasets running over a Web Processing Service (WPS). For quality procedures that require an external reference dataset, like positional accuracy or completeness, the architecture permits using a reference dataset. However, this reference dataset is not ageless, since it suffers the natural time degradation inherent to geospatial features. In order to mitigate this problem we propose the Time Degradation & Updating Module which intends to apply assessed data as a tool to maintain the reference database updated. The main idea is to utilize datasets sent to the quality evaluation service as a source of 'candidate data elements' for the updating of the reference database. After the evaluation, if some elements of a candidate dataset reach a determined quality level, they can be used as input data to improve the current reference database. In this work we present the first design of the Time Degradation & Updating Module. We believe that the outcomes can be applied in the search of a full-automatic on-line quality evaluation platform.

Evaluating disease management program effectiveness: an introduction to time-series analysis.

PubMed

Linden, Ariel; Adams, John L; Roberts, Nancy

2003-01-01

Currently, the most widely used method in the disease management (DM) industry for evaluating program effectiveness is referred to as the "total population approach." This model is a pretest-posttest design, with the most basic limitation being that without a control group, there may be sources of bias and/or competing extraneous confounding factors that offer a plausible rationale explaining the change from baseline. Furthermore, with the current inclination of DM programs to use financial indicators rather than program-specific utilization indicators as the principal measure of program success, additional biases are introduced that may cloud evaluation results. This paper presents a non-technical introduction to time-series analysis (using disease-specific utilization measures) as an alternative, and more appropriate, approach to evaluating DM program effectiveness than the current total population approach.

Development of Electronic Load Controllers for Free-Piston Stirling Convertors Aided by Stirling Simulation Model

NASA Technical Reports Server (NTRS)

Regan, Timothy F.

2004-01-01

The free-piston Stirling convertor end-to-end modeling effort at the NASA Glenn Research Center has produced a software-based test bed in which free-piston Stirling convertors can be simulated and evaluated. The simulation model includes all the components of the convertor: the Stirling cycle engine, heat source, linear alternator, controller, and load. So far, it has been used in evaluating the performance of electronic controller designs. Three different controller design concepts were simulated using the model: 1) Controllers with parasitic direct current loading. 2) Controllers with parasitic alternating current loading. 3) Controllers that maintain a reference current. The free-piston Stirling convertor is an electromechanical device that operates at resonance. It is the function of the electronic load controller to ensure that the electrical load seen by the machine is always great enough to keep the amplitude of the piston and alternator oscillation at the rated value. This is done by regulating the load on the output bus. The controller monitors the instantaneous voltage, regulating it by switching loads called parasitic loads onto the bus whenever the bus voltage is too high and removing them whenever the voltage is too low. In the first type of controller, the monitor-ing and switching are done on the direct-current (dc) bus. In the second type, the alternating current bus is used. The model allows designers to test a controller concept before investing time in hardware. The simulation code used to develop the model also offers detailed models of digital and analog electronic components so that the resulting designs are realistic enough to translate directly into hardware circuits.

Analysis and design of gain scheduled control systems. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Shamma, Jeff S.

1988-01-01

Gain scheduling, as an idea, is to construct a global feedback control system for a time varying and/or nonlinear plant from a collection of local time invariant designs. However in the absence of a sound analysis, these designs come with no guarantees on the robustness, performance, or even nominal stability of the overall gain schedule design. Such an analysis is presented for three types of gain scheduling situations: (1) a linear parameter varying plant scheduling on its exogenous parameters, (2) a nonlinear plant scheduling on a prescribed reference trajectory, and (3) a nonlinear plant scheduling on the current plant output. Conditions are given which guarantee that the stability, robustness, and performance properties of the fixed operating point designs carry over to the global gain scheduled designs, such as the scheduling variable should vary slowly and capture the plants nonlinearities. Finally, an alternate design framework is proposed which removes the slowing varying restriction or gain scheduled systems. This framework addresses some fundamental feedback issues previously ignored in standard gain.

Temperature compensated and self-calibrated current sensor using reference current

DOEpatents

Yakymyshyn, Christopher Paul [Seminole, FL; Brubaker, Michael Allen [Loveland, CO; Yakymyshyn, Pamela Jane [Seminole, FL

2008-01-22

A method is described to provide temperature compensation and self-calibration of a current sensor based on a plurality of magnetic field sensors positioned around a current carrying conductor. A reference electrical current carried by a conductor positioned within the sensing window of the current sensor is used to correct variations in the output signal due to temperature variations and aging.

Pseudo-differential CMOS analog front-end circuit for wide-bandwidth optical probe current sensor

NASA Astrophysics Data System (ADS)

Uekura, Takaharu; Oyanagi, Kousuke; Sonehara, Makoto; Sato, Toshiro; Miyaji, Kousuke

2018-04-01

In this paper, we present a pseudo-differential analog front-end (AFE) circuit for a novel optical probe current sensor (OPCS) aimed for high-frequency power electronics. It employs a regulated cascode transimpedance amplifier (RGC-TIA) to achieve a high gain and a large bandwidth without using an extremely high performance operational amplifier. The AFE circuit is designed in a 0.18 µm standard CMOS technology achieving a high transimpedance gain of 120 dB Ω and high cut off frequency of 16 MHz. The measured slew rate is 70 V/µs and the input referred current noise is 1.02 pA/\\sqrt{\\text{Hz}} . The magnetic resolution and bandwidth of OPCS are estimated to be 1.29 mTrms and 16 MHz, respectively; the bandwidth is higher than that of the reported Hall effect current sensor.

A Microwave Driven Ion Source for Continuous-Flow AMS (Abstract)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wills, J.; Schneider, R.J.; Reden, K.F. von

2005-03-15

A microwave-driven, gas-fed ion source originally developed as a high-current positive ion injector for a Tandem accelerator at Chalk River has been the subject of a three-year development program at the Woods Hole Oceanographic Institution NOSAMS facility. Off-line tests have demonstrated positive carbon currents of 1 mA and negative carbon currents of 80 {mu}A from CO2 gas feed. This source and a magnesium charge-exchange canal were coupled to the recombinator of the NOSAMS Tandetron for on-line tests, with the source fed with reference gasses and a combustion device.The promising results obtained have prompted the redesign of the microwave source formore » use as an on-line, continuous-flow injector for a new AMS facility under construction at NOSAMS. The new design is optimized for best transmission of the extracted positive-ion beam through the charge-exchange canal and for reliable operation at 40 kV extraction voltage. Other goals of the re-design include improved lifetime of the microwave window and the elimination of dead volumes in the plasma generator that increase sample hold-up time.This talk will include a summary of results obtained to date at NOSAMS with the Chalk River source and a detailed description of the new design.« less

Requirements and Designs for Mars Rover RTGs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schock, Alfred; Shirbacheh, M; Sankarankandath, V

The current-generation RTGs (both GPHS and MOD) are designed for operation in a vacuum environment. The multifoil thermal insulation used in those RTGs only functions well in a good vacuum. Current RTGs are designed to operate with an inert cover gas before launch, and to be vented to space vacuum after launch. Both RTGs are sealed with a large number of metallic C-rings. Those seals are adequate for retaining the inert-gas overpressure during short-term launch operations, but would not be adequate to prevent intrusion of the Martian atmospheric gases during long-term operations there. Therefore, for the Mars Rover application, thosemore » RTGs just be modified to prevent the buildup of significant pressures of Mars atmosphere or of helium (from alpha decay of the fuel). In addition, a Mars Rover RTG needs to withstand a long-term dynamic environment that is much more severe than that seen by an RTG on an orbiting spacecraft or on a stationary planetary lander. This paper describes a typical Rover mission, its requirements, the environment it imposes on the RTG, and a design approach for making the RTG operable in such an environment. Specific RTG designs for various thermoelectric element alternatives are presented.; Reference CID #9268 and CID #9276.« less

Integrating Design and Manufacturing for a High Speed Civil Transport Wing

NASA Technical Reports Server (NTRS)

Marx, William J.; Mavris, Dimitri N.; Schrage, Daniel P.

1994-01-01

The aerospace industry is currently addressing the problem of integrating design and manufacturing. Because of the difficulties associated with using conventional, procedural techniques and algorithms, it is the authors' belief that the only feasible way to integrate the two concepts is with the development of an appropriate Knowledge-Based System (KBS). The authors propose a methodology for an aircraft producibility assessment, including a KBS, that addresses both procedural and heuristic aspects of integrating design and manufacturing of a High Speed Civil Transport (HSCT) wing. The HSCT was chosen as the focus of this investigation since it is a current NASA/aerospace industry initiative full of technological challenges involving many disciplines. The paper gives a brief background of selected previous supersonic transport studies followed by descriptions of key relevant design and manufacturing methodologies. Georgia Tech's Concurrent Engineering/Integrated Product and Process Development methodology is discussed with reference to this proposed conceptual producibility assessment. Evaluation criteria are presented that relate pertinent product and process parameters to overall product producibility. In addition, the authors' integration methodology and reasons for selecting a KBS to integrate design and manufacturing are presented in this paper. Finally, a proposed KBS is given, as well as statements of future work and overall investigation objectives.

Design and simulation of control algorithms for stored energy and plasma current in non-inductive scenarios on NSTX-U

NASA Astrophysics Data System (ADS)

Boyer, Mark; Andre, Robert; Gates, David; Gerhardt, Stefan; Menard, Jonathan; Poli, Francesca

2015-11-01

One of the major goals of NSTX-U is to demonstrate non-inductive operation. To facilitate this and other program goals, the center stack has been upgraded and a second neutral beam line has been added with three sources aimed more tangentially to provide higher current drive efficiency and the ability to shape the current drive profile. While non-inductive start-up and ramp-up scenarios are being developed, initial non-inductive studies will likely rely on clamping the Ohmic coil current after the plasma current has been established inductively. In this work the ability to maintain control of stored energy and plasma current once the Ohmic coil has been clamped is explored. The six neutral beam sources and the mid-plane outer gap of the plasma are considered as actuators. System identification is done using TRANSP simulations in which the actuators are modulated around a reference shot. The resulting reduced model is used to design an optimal control law with anti-windup and a recently developed framework for closed loop simulations in TRANSP is used to test the control. Limitations due to actuator saturation are assessed and robustness to beam modulation, changes in the plasma density and confinement, and changes in density and temperature profile shapes are studied. Supported by US DOE contract DE-AC02-09CH11466.

Microfluidic large-scale integration: the evolution of design rules for biological automation.

PubMed

Melin, Jessica; Quake, Stephen R

2007-01-01

Microfluidic large-scale integration (mLSI) refers to the development of microfluidic chips with thousands of integrated micromechanical valves and control components. This technology is utilized in many areas of biology and chemistry and is a candidate to replace today's conventional automation paradigm, which consists of fluid-handling robots. We review the basic development of mLSI and then discuss design principles of mLSI to assess the capabilities and limitations of the current state of the art and to facilitate the application of mLSI to areas of biology. Many design and practical issues, including economies of scale, parallelization strategies, multiplexing, and multistep biochemical processing, are discussed. Several microfluidic components used as building blocks to create effective, complex, and highly integrated microfluidic networks are also highlighted.

Ceramic automotive Stirling engine study

NASA Technical Reports Server (NTRS)

Musikant, S.; Chiu, W.; Darooka, D.; Mullings, D. M.; Johnson, C. A.

1985-01-01

A conceptual design study for a Ceramic Automotive Stirling Engine (CASE) is performed. Year 1990 structural ceramic technology is assumed. Structural and performance analyses of the conceptual design are performed as well as a manufacturing and cost analysis. The general conclusions from this study are that such an engine would be 10-26% more efficient over its performance map than the current metal Automotive Stirling Reference Engine (ASRE). Cost of such a ceramic engine is likely to be somewhat higher than that of the ASRE but engine cost is very sensitive to the ultimate cost of the high purity, ceramic powder raw materials required to fabricate high performance parts. When the design study is projected to the year 2000 technology, substantinal net efficiency improvements, on the order of 25 to 46% over the ASRE, are computed.

Tissue resistivities determine the current flow in the cochlea.

PubMed

Micco, Alan Gerard; Richter, Claus-Peter

2006-10-01

In individuals with severe to profound hearing loss, cochlear implants bypass normal inner ear function by applying electrical current directly into the cochlea, thereby stimulating cochlear nerve fibers. Stimulating discrete populations of spiral ganglion cells in cochlear implant users' ears is similar to the encoding of small acoustic frequency bands in a normal-hearing person's ear. Thus, spiral ganglion cells stimulated by an electrode convey the information contained by a small acoustic frequency band. Problems that refer to the current spread and subsequent nonselective stimulation of spiral ganglion cells in the cochlea are reviewed. Cochlear anatomy and tissue properties determine the current path in the cochlea. Current spreads largely via scala tympani and across turns. While most of the current leaves the cochlea via the modiolus, the facial canal and the round window constitute additional natural escape paths for the current from the cochlea. Moreover, degenerative processes change tissue resistivities and thus may affect current spread in the cochlea. Electrode design and coding strategies may result in more spatial stimulation of spiral ganglion cells, resulting in a better performance of the electrode-tissue interface.

Validity of Guatemalan Mother's Self-Reported Breast-Feeding Practices of 3-Month-Old Infants.

PubMed

Mazariegos, Monica; Slater, Christine; Ramirez-Zea, Manuel

2016-12-01

Breast-feeding practices (BFPs) can be assessed by interviewing the mother about current feeding practices and with a 24-hour recall. It is crucial to establish the accuracy of these methods, which are commonly used by public health decision makers to design health policies aimed at increasing exclusive breast-feeding rates. We aimed to validate 2 self-report BFP instruments using the dose-to-mother deuterium oxide turnover technique (DMDOT) as the reference method. Breast-feeding practices were assessed by interviewing the mother about current feeding practices and with a 24-hour recall in 36 Guatemalan mother-infant pairs. The validity of these instruments was assessed using DMDOT as the reference method. Both self-report instruments overestimated exclusively breast-fed (EBF) infants. Infants classified as EBF were 50% by the reported current feeding practice, 61% by the 24-hour recall, and only 36% using DMDOT. Sensitivity to detect EBF infants from the mother's self-report was 92% (95% CI: 62%-99%) while from the 24-hour recall was 100% (95% CI: 72%-100%, P < .01). However, specificity for both instruments was low, at 74% (95% CI: 51%-89%) for reported current feeding practice and at 61% (95% CI: 39%-79%) for the 24-hour recall (P < .01). Both reported current feeding practice and the 24-hour recall instruments overestimated exclusive breast-feeding. Nevertheless, the use of reported current feeding practice provided more accurate data to assess BFPs in a public health setting. Furthermore, population-based surveys should consider the overestimation of exclusive breast-feeding caused when using these BFP instruments. © The Author(s) 2016.

[The current views of the problem of the plastic correction of the laryngo-tracheal defects in the patients presenting with combined laryngeal stenoses].

PubMed

Selezneva, L V

2017-01-01

The present review of the literature is designed to analyze the currently available methods for the plastic correction of the laryngo-tracheal defects in the patients presenting with combined laryngeal stenoses at the concluding stage of their medical rehabilitation. We looked through 56 literature sources including 28 publications of the foreign authors. The different approaches to the plastic correction of the laryngo-tracheal defects have been critically considered with special reference to their advantages and disadvantages. The importance of the problem under consideration arises from the necessity of the search for the new methods of plastic correction of the laryngo-tracheal defects.

Integrated Mecical Model (IMM) 4.0 Verification and Validation (VV) Testing (HRP IWS 2016)

NASA Technical Reports Server (NTRS)

Walton, M; Kerstman, E.; Arellano, J.; Boley, L.; Reyes, D.; Young, M.; Garcia, Y.; Saile, L.; Myers, J.

2016-01-01

Timeline, partial treatment, and alternate medications were added to the IMM to improve the fidelity of this model to enhance decision support capabilities. Using standard design reference missions, IMM VV testing compared outputs from the current operational IMM (v3) with those from the model with added functionalities (v4). These new capabilities were examined in a comparative, stepwise approach as follows: a) comparison of the current operational IMM v3 with the enhanced functionality of timeline alone (IMM 4.T), b) comparison of IMM 4.T with the timeline and partial treatment (IMM 4.TPT), and c) comparison of IMM 4.TPT with timeline, partial treatment and alternative medication (IMM 4.0).

Dustfall design of open coal yard in the power plant-a case study on the closed reconstruction project of coal storage yard in shengli power plant

NASA Astrophysics Data System (ADS)

Wang, Kunpeng; Ji, Weidong; Zhang, Feifei; Yu, Wei; Zheng, Runqing

2018-02-01

This thesis, based on the closed reconstruction project of the coal storage yard of Shengli Power Plant which is affiliated to Sinopec Shengli Petroleum Administration, first makes an analysis on the significance of current dustfall reconstruction of open coal yard, then summarizes the methods widely adopted in the dustfall of large-scale open coal storage yard of current thermal power plant as well as their advantages and disadvantages, and finally focuses on this project, aiming at providing some reference and assistance to the future closed reconstruction project of open coal storage yard in thermal power plant.

Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

NASA Astrophysics Data System (ADS)

Boissonnat, Guillaume; Fontbonne, Jean-Marc; Balanzat, Emmanuel; Boumard, Frederic; Carniol, Benjamin; Cassimi, Amine; Colin, Jean; Cussol, Daniel; Etasse, David; Fontbonne, Cathy; Frelin, Anne-Marie; Hommet, Jean; Salvador, Samuel

2017-06-01

Currently, radiobiology experiments using heavy ions at GANIL (Grand Accélérateur National d‧Ions Lourds) are conducted under the supervision of the CIMAP (Center for research on Ions, MAterials and Photonics). In this context, a new beam monitoring equipment named DOSION has been developed. It allows to perform measurements of accurate fluence and dose maps in near real time for each biological sample irradiated. In this paper, we present the detection system, its design, performances, calibration protocol and measurements performed during radiobiology experiments. This setup is currently available for any radiobiology experiments if one wishes to correlate one's own sample analysis to state-of-the-art dosimetric references.

The effects of user factors and symbol referents on public symbol design using the stereotype production method.

PubMed

Ng, Annie W Y; Siu, Kin Wai Michael; Chan, Chetwyn C H

2012-01-01

This study investigated the influence of user factors and symbol referents on public symbol design among older people, using the stereotype production method for collecting user ideas during the symbol design process. Thirty-one older adults were asked to draw images based on 28 public symbol referents and to indicate their familiarity with and ease with which they visualised each referent. Differences were found between the pictorial solutions generated by males and females. However, symbol design was not influenced by participants' education level, vividness of visual imagery, object imagery preference or spatial imagery preference. Both familiar and unfamiliar referents were illustrated pictorially without much difficulty by users. The more visual the referent, the less difficulty the users had in illustrating it. The findings of this study should aid the optimisation of the stereotype production method for user-involved symbol design. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Coastwide Reference Monitoring System (CRMS)

USGS Publications Warehouse

2010-01-01

In 1990, the U.S. Congress enacted the Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) in response to growing awareness of a land loss crisis in Louisiana. Projects funded by CWPPRA require monitoring and evaluation of project effectiveness, and there is also a need to assess the cumulative effects of all projects to achieve a sustainable coastal environment. In 2003, the Louisiana Office of Coastal Protection and Restoration (OCPR) and the U.S. Geological Survey (USGS) received approval from the CWPPRA Task Force to implement the Coastwide Reference Monitoring System (CRMS) as a mechanism to monitor and evaluate the effectiveness of CWPPRA projects at the project, region, and coastwide levels. The CRMS design implements a multiple reference approach by using aspects of hydrogeomorphic functional assessments and probabilistic sampling. The CRMS program is as dynamic as the coastal habitats it monitors. The program is currently funded through CWPPRA and provides data for a variety of user groups, including resource managers, academics, landowners, and researchers.

Closed-loop analysis and control of a non-inverting buck-boost converter

NASA Astrophysics Data System (ADS)

Chen, Zengshi; Hu, Jiangang; Gao, Wenzhong

2010-11-01

In this article, a cascade controller is designed and analysed for a non-inverting buck-boost converter. The fast inner current loop uses sliding mode control. The slow outer voltage loop uses the proportional-integral (PI) control. Stability analysis and selection of PI gains are based on the nonlinear closed-loop error dynamics incorporating both the inner and outer loop controllers. The closed-loop system is proven to have a nonminimum phase structure. The voltage transient due to step changes of input voltage or resistance is predictable. The operating range of the reference voltage is discussed. The controller is validated by a simulation circuit. The simulation results show that the reference output voltage is well-tracked under system uncertainties or disturbances, confirming the validity of the proposed controller.

Real time simulation of nonlinear generalized predictive control for wind energy conversion system with nonlinear observer.

PubMed

Ouari, Kamel; Rekioua, Toufik; Ouhrouche, Mohand

2014-01-01

In order to make a wind power generation truly cost-effective and reliable, an advanced control techniques must be used. In this paper, we develop a new control strategy, using nonlinear generalized predictive control (NGPC) approach, for DFIG-based wind turbine. The proposed control law is based on two points: NGPC-based torque-current control loop generating the rotor reference voltage and NGPC-based speed control loop that provides the torque reference. In order to enhance the robustness of the controller, a disturbance observer is designed to estimate the aerodynamic torque which is considered as an unknown perturbation. Finally, a real-time simulation is carried out to illustrate the performance of the proposed controller. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

New technology and regional studies in human ecology: A Papua New Guinea example

NASA Technical Reports Server (NTRS)

Morren, George E. B., Jr.

1991-01-01

Two key issues in using technologies such as digital image processing and geographic information systems are a conceptually and methodologically valid research design and the exploitation of varied sources of data. With this realized, the new technologies offer anthropologists the opportunity to test hypotheses about spatial and temporal variations in the features of interest within a regionally coherent mosaic of social groups and landscapes. Current research on the Mountain OK of Papua New Guinea is described with reference to these issues.

Instruct coders' manual

NASA Technical Reports Server (NTRS)

Friend, J.

1971-01-01

A manual designed both as an instructional manual for beginning coders and as a reference manual for the coding language INSTRUCT, is presented. The manual includes the major programs necessary to implement the teaching system and lists the limitation of current implementation. A detailed description is given of how to code a lesson, what buttons to push, and what utility programs to use. Suggestions for debugging coded lessons and the error messages that may be received during assembly or while running the lesson are given.

Power Requirements for Bi-Harmonic Amplitude and Bias Modulation Control of a Flapping Wing Micro Air Vehicle

DTIC Science & Technology

2013-03-01

acquisition DC Direct current DHPC Discrete harmonic plant compensation DLMs Dorsal longitudinal muscles DOE Design of experiments DOF Degrees of...nature, would have the inherent benefit of stealth through mimicry of insects. Such a MAV is referred to as a flapping wing micro air vehicle (FWMAV...and discrete harmonic plant compensation (DHPC) to manipulate the wings of the FWMAV. A clear understanding of what research has been done in all of

The marketing of dissolvable tobacco: social science and public policy research needs.

PubMed

Southwell, Brian G; Kim, Annice E; Tessman, Greta K; MacMonegle, Anna J; Choiniere, Conrad J; Evans, Sarah E; Johnson, Robin D

2012-01-01

The latest generation of smokeless tobacco products encompasses a wide range of offerings, including what is commonly referred to as dissolvable tobacco. Designed to deliver nicotine upon dissolving or disintegrating in a user's mouth, dissolvable tobacco products currently appear in various United States markets as strips, orbs, sticks, and lozenges. The emergence of these new products poses distinct opportunities and challenges for social and behavioral science and public health research and raises important public policy questions.

Effect of density feedback on the two-route traffic scenario with bottleneck

NASA Astrophysics Data System (ADS)

Sun, Xiao-Yan; Ding, Zhong-Jun; Huang, Guo-Hua

2016-12-01

In this paper, we investigate the effect of density feedback on the two-route scenario with a bottleneck. The simulation and theory analysis shows that there exist two critical vehicle entry probabilities αc1 and αc2. When vehicle entry probability α≤αc1, four different states, i.e. free flow state, transition state, maximum current state and congestion state are identified in the system, which correspond to three critical reference densities. However, in the interval αc1<α<αc2, the free flow and transition state disappear, and there is only congestion state when α≥αc2. According to the results, traffic control center can adjust the reference density so that the system is in maximum current state. In this case, the capacity of the traffic system reaches maximum so that drivers can make full use of the roads. We hope that the study results can provide good advice for alleviating traffic jam and be useful to traffic control center for designing advanced traveller information systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stovall, J.P.; RIzy, D.T.; Kisner, R.A.

The 3M Company has developed a high-temperature low-sag conductor referred to as Aluminum- Conductor Composite-Reinforced or ACCR. The conductor uses an aluminum metal matrix material to replace the steel in conventional conductors so the core has a lower density and higher conductivity. The objective of this work is to accelerate the commercial acceptance by electric utilities of these new conductor designs by testing four representative conductor classes in controlled conditions. Overhead transmission lines use bare aluminum conductor strands wrapped around a steel core strands to transmit electricity. The typical cable is referred to as aluminum-conductor steel-reinforced (ACSR). The outer strandsmore » are aluminum, chosen for its conductivity, low weight, and low cost. The center strand is of steel for the strength required to support the weight without stretching the aluminum due to its ductility. The power density of a transmission corridor has been directly increased by increasing the voltage level. Transmission voltages have increased from 115-kV to 765- kV over the past 80 years. In the United States, further increasing the voltage level is not feasible at this point in time, so in order to further increase the power density of a transmission corridor, conductor designs that increase the current carrying capability have been examined. One of the key limiting factors in the design of a transmission line is the conductor sag which determines the clearance of the conductor above ground or underlying structures needed for electrical safety. Increasing the current carrying capability of a conductor increases the joule heating in the conductor which increases the conductor sag. A conductor designed for high-temperature and lowsag operation requires an engineered modification of the conductor materials. To make an advanced cable, the 3M Company solution has been the development of a composite conductor consisting of Nextel ceramic fibers to replace the steel core and an aluminum-zirconium alloy to improve the outer strands. The result is a cable that can carry more current than steelaluminum lines without sagging as much at higher temperatures. A unique facility called the Powerline Conductor Accelerated Testing (PCAT) Facility was built at ORNL for testing overhead conductors. The PCAT has been uniquely designed for testing overhead bare transmission line conductors at high currents and temperatures after they have been installed and tensioned to the manufacturer's specifications. The ability to operate a transmission line conductor in this manner does not exist elsewhere in the United States. Four classes of ACCR cable designed by 3M have been successfully test at ORNL – small, medium, large and small/compact. Based on these and other manufacturer tests, the 3M Company has successfully introduced the ACCR into the commercial market and has completed over twenty installations for utility companies.« less

Civil engineering reference guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merritt, F.S.

1986-01-01

The civil engineering reference guide contains the following: Structural theory. Structural steel design. Concrete design and construction. Wood design and construction. Bridge engineering. Geotechnical engineering. Water engineering. Environmental engineering. Surveying.

Exploring Optimization Opportunities in Four-Point Suspension Wind Turbine Drivetrains Through Integrated Design Approaches: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sethuraman, Latha; Quick, Julian; Guo, Yi

Drivetrain design has significant influence on the costs of wind power generation. Current industry practices usually approach the drivetrain design with loads and system requirements defined by the turbine manufacturer. Several different manufacturers are contracted to supply individual components from the low-speed shaft to the generator - each receiving separate design specifications from the turbine manufacturer. Increasingly, more integrated approaches to turbine design have shown promise for blades and towers. Yet, integrated drivetrain design is a challenging task owing to the complex physical behavior of the important load-bearing components, namely the main bearings, gearbox, and the generator. In this papermore » we combine two of NREL's systems engineering design tools, DriveSE and GeneratorSE, to enable a comprehensive system-level drivetrain optimization for the IEAWind reference turbine for land-based applications. We compare a more traditional design with integrated approaches employing decoupled and coupled design optimization. It is demonstrated that both approaches have the potential to realize notable mass savings with opportunities to lower the costs of energy.« less

Exploring Optimization Opportunities in Four-Point Suspension Wind Turbine Drivetrains through Integrated Design Approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sethuraman, Latha; Quick, Julian; Guo, Yi

Drivetrain design has significant influence on the costs of wind power generation. Current industry practices usually approach the drivetrain design with loads and system requirements defined by the turbine manufacturer. Several different manufacturers are contracted to supply individual components from the low-speed shaft to the generator - each receiving separate design specifications from the turbine manufacturer. Increasingly, more integrated approaches to turbine design have shown promise for blades and towers. Yet, integrated drivetrain design is a challenging task owing to the complex physical behavior of the important load-bearing components, namely the main bearings, gearbox, and the generator. In this papermore » we combine two of NREL's systems engineering design tools, DriveSE and GeneratorSE, to enable a comprehensive system-level drivetrain optimization for the IEAWind reference turbine for land-based applications. We compare a more traditional design with integrated approaches employing decoupled and coupled design optimization. It is demonstrated that both approaches have the potential to realize notable mass savings with opportunities to lower the costs of energy.« less

Evaluating and defining the sharpness of intraocular lenses: microedge structure of commercially available square-edged hydrophobic lenses.

PubMed

Werner, Liliana; Müller, Matthias; Tetz, Manfred

2008-02-01

To evaluate the microstructure of the edges of currently available square-edged hydrophobic intraocular lenses (IOLs) in terms of their deviation from an ideal square. Berlin Eye Research Institute, Berlin, Germany. Sixteen designs of hydrophobic acrylic or silicone IOLs were studied. For each design, a +20.0 diopter (D) IOL and a +0.0 D IOL (or the lowest available plus dioptric power) were evaluated. The IOL edge was imaged under high-magnification scanning electron microscopy using a standardized technique. The area above the lateral-posterior edge, representing the deviation from a perfect square, was measured in square microns using reference circles of 40 microm and 60 microm of radius and the AutoCAD LT 2000 system (Autodesk). The IOLs were compared with an experimental square-edged poly(methyl methacrylate) (PMMA) IOL (reference IOL) with an edge design that effectively stopped lens epithelial cell growth in culture in a preliminary study. Two round-edged silicone IOLs were used as controls. The hydrophobic IOLs used, labeled as square-edged IOLs, had an area of deviation from a perfect square ranging from 4.8 to 338.4 microm(2) (40 microm radius reference circle) and from 0.2 to 524.4 microm(2) (60 microm radius circle). The deviation area for the square-edged PMMA IOL was 34.0 microm(2) with a 40 microm radius circle and 37.5 microm(2) with a 60 microm radius circle. The respective values for the +20.0 D control silicone IOL were 729.3 microm(2) and 1525.3 microm(2) and for the +0.0 D control silicone IOL, 727.3 microm(2) and 1512.7 microm(2). Seven silicone IOLs of 5 designs had area values that were close to those of the reference square-edged PMMA IOL. Several differences in edge finishing between the IOLs analyzed were also observed. There was a large variation in the deviation area from a perfect square as well as in the edge finishing, not only between different IOL designs but also between different powers of the same design. Clinically, factors such as the shrink-wrapping of the IOL by the capsule may even out or modify the influence of these variations in terms of preventing posterior capsule opacification.

Does a gatekeeper suicide prevention program work in a school setting? Evaluating training outcome and moderators of effectiveness.

PubMed

Tompkins, Tanya L; Witt, Jody; Abraibesh, Nadia

2009-12-01

The current study sought to evaluate the suicide prevention gatekeeper training program QPR (Question, Persuade, and Refer) among school personnel using a non-equivalent control group design. Substantial gains were demonstrated from pre- to post-test for attitudes, knowledge, and beliefs regarding suicide and suicide prevention. Exploratory analyses revealed the possible moderating effects of age, professional role, prior training, and recent contact with suicidal youth on QPR participants' general knowledge, questioning, attitudes toward suicide and suicide prevention, QPR quiz scores, and self-efficacy. The need for replication using a more rigorous experimental design in the context of strong community collaboration is discussed.

Energy absorption capability and crashworthiness of composite material structures: A review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carruthers, J.J.; Kettle, A.P.; Robinson, A.M.

1998-10-01

The controlled brittle failure of thermosetting fiber-reinforced polymer composites can provide a very efficient energy absorption mechanism. Consequently, the use of these materials in crashworthy vehicle designs has been the subject of considerable interest. In this respect, their more widespread application has been limited by the complexity of their collapse behavior. This article reviews the current level of understanding i this field, including the correlations between failure mode and energy absorption, the principal material, geometric, and physical parameters relevant to crashworthy design and methods of predicting the energy absorption capability of polymer composites. Areas which require further investigation are identified.more » This review article contains 70 references.« less

Design and implementation of online automatic judging system

NASA Astrophysics Data System (ADS)

Liang, Haohui; Chen, Chaojie; Zhong, Xiuyu; Chen, Yuefeng

2017-06-01

For lower efficiency and poorer reliability in programming training and competition by currently artificial judgment, design an Online Automatic Judging (referred to as OAJ) System. The OAJ system including the sandbox judging side and Web side, realizes functions of automatically compiling and running the tested codes, and generating evaluation scores and corresponding reports. To prevent malicious codes from damaging system, the OAJ system utilizes sandbox, ensuring the safety of the system. The OAJ system uses thread pools to achieve parallel test, and adopt database optimization mechanism, such as horizontal split table, to improve the system performance and resources utilization rate. The test results show that the system has high performance, high reliability, high stability and excellent extensibility.

Calculation and Analysis of Dynamic Characteristics of Multilink Permanent Magnetic Actuator in Vacuum Circuit Breaker

NASA Astrophysics Data System (ADS)

Liu, Yingyi; Yuan, Haiwen; Zhang, Qingjie; Chen, Degui; Yuan, Haibin

The dynamic characteristics are the key issues in the optimum design of a permanent magnetic actuator (PMA). A new approach to forecast the dynamic characteristics of the multilink PMA is proposed. By carrying out further developments of ADAMS and ANSOFT, a mathematic calculation model describing the coupling of mechanical movement, electric circuit and magnetic field considering eddy current effect, is constructed. With this model, the dynamic characteristics of the multilink PMA are calculated and compared with the experimental results. Factors that affect the opening time of the multilink PMA are analyzed with the model as well. The method is capable of providing a reference for the design of the PMA.

Engaging teenagers productively in service design.

PubMed

Bowen, Simon; Sustar, Helena; Wolstenholme, Daniel; Dearden, Andy

2013-09-01

Engaging young people in participatory design can be challenging, particularly in health-related projects. In a study co-designing diabetes support and information services with teenagers, we found framing activities using popular culture was a useful strategy. Various cultural references helped us stage activities that were productive for the design process, and were engaging for our young participants (e.g. exploring practical implications through discussions in a 'Dragons' Den'). Some activities were more effective than others and the idea of language-games , which has been widely explored in participatory design, explains why our strategy was successful when there was a clear 'family resemblance' between the popular cultural references and certain essential stages of designing. However, attention is required in selecting appropriate cultural references if this strategy is adopted elsewhere, and design facilitators should focus first on devising accessible language-games, rather than expecting popular cultural references to provide complete solutions to the challenge of staging participatory design.

Dynamic optimization and adaptive controller design

NASA Astrophysics Data System (ADS)

Inamdar, S. R.

2010-10-01

In this work I present a new type of controller which is an adaptive tracking controller which employs dynamic optimization for optimizing current value of controller action for the temperature control of nonisothermal continuously stirred tank reactor (CSTR). We begin with a two-state model of nonisothermal CSTR which are mass and heat balance equations and then add cooling system dynamics to eliminate input multiplicity. The initial design value is obtained using local stability of steady states where approach temperature for cooling action is specified as a steady state and a design specification. Later we make a correction in the dynamics where material balance is manipulated to use feed concentration as a system parameter as an adaptive control measure in order to avoid actuator saturation for the main control loop. The analysis leading to design of dynamic optimization based parameter adaptive controller is presented. The important component of this mathematical framework is reference trajectory generation to form an adaptive control measure.

Aircraft gas turbine low-power emissions reduction technology program

NASA Technical Reports Server (NTRS)

Dodds, W. J.; Gleason, C. C.; Bahr, D. W.

1978-01-01

Advanced aircraft turbine engine combustor technology was used to reduce low-power emissions of carbon monoxide and unburned hydrocarbons to levels significantly lower than those which were achieved with current technology. Three combustor design concepts, which were designated as the hot-wall liner concept, the recuperative-cooled liner concept, and the catalyst converter concept, were evaluated in a series of CF6-50 engine size 40 degree-sector combustor rig tests. Twenty-one configurations were tested at operating conditions spanning the design condition which was an inlet temperature and pressure of 422 K and 304 kPa, a reference velocity of 23 m/s and a fuel-air-ration of 10.5 g/kg. At the design condition typical of aircraft turbine engine ground idle operation, the best configurations of all three concepts met the stringent emission goals which were 10, 1, and 4 g/kg for CO, HC, and Nox, respectively.

Computer-aided design and manufacturing of surgical templates and their clinical applications: a review.

PubMed

Chen, Xiaojun; Xu, Lu; Wang, Wei; Li, Xing; Sun, Yi; Politis, Constantinus

2016-09-01

The surgical template is a guide aimed at directing the implant placement, tumor resection, osteotomy and bone repositioning. Using it, preoperative planning can be transferred to the actual surgical site, and the precision, safety and reliability of the surgery can be improved. However, the actual workflow of the surgical template design and manufacturing is quite complicated before the final clinical application. The major goal of the paper is to provide a comprehensive reference source of the current and future development of the template design and manufacturing for relevant researchers. Expert commentary: This paper aims to present a review of the necessary procedures in the template-guided surgery including the image processing, 3D visualization, preoperative planning, surgical guide design and manufacturing. In addition, the template-guided clinical applications for various kinds of surgeries are reviewed, and it demonstrated that the precision of the surgery has been improved compared with the non-guided operations.

Localised electrochemical impedance measurements of a polymer electrolyte fuel cell using a reference electrode array to give cathode-specific measurements and examine membrane hydration dynamics

NASA Astrophysics Data System (ADS)

Engebretsen, Erik; Hinds, Gareth; Meyer, Quentin; Mason, Tom; Brightman, Edward; Castanheira, Luis; Shearing, Paul R.; Brett, Daniel J. L.

2018-04-01

Advances in bespoke diagnostic techniques for polymer electrolyte fuel cells continue to provide unique insight into the internal operation of these devices and lead to improved performance and durability. Localised measurements of current density have proven to be extremely useful in designing better fuel cells and identifying optimal operating strategies, with electrochemical impedance spectroscopy (EIS) now routinely used to deconvolute the various losses in fuel cells. Combining the two techniques provides another dimension of understanding, but until now each localised EIS has been based on 2-electrode measurements, composed of both the anode and cathode responses. This work shows that a reference electrode array can be used to give individual electrode-specific EIS responses, in this case the cathode is focused on to demonstrate the approach. In addition, membrane hydration dynamics are studied under current load steps from open circuit voltage. A three-stage process is identified associated with an initial rapid reduction in membrane resistance after 10 s of applying a current step, followed by a slower ramp to approximately steady state, which was achieved after ∼250 s. These results support previously published work that has looked at membrane swelling dynamics and reveal that membrane hydration/membrane resistance is highly heterogeneous.

10 CFR 50.150 - Aircraft impact assessment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

10 CFR 50.150 - Aircraft impact assessment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

10 CFR 50.150 - Aircraft impact assessment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

10 CFR 50.150 - Aircraft impact assessment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13, 2009; (B) Renewal of standard design certifications in effect on July 13, 2009 which have not..., standard design approval, or manufactured reactor; or (B) Reference a standard design certification issued... certification or standard design approval; or (B) Reference a standard design certification issued before July...

HEDS-UP Mars Exploration Forum

NASA Technical Reports Server (NTRS)

Budden, Nancy Ann (Editor); Duke, Micheal B. (Editor)

1998-01-01

In the early 1990s, Duke and Budden convened a series of workshops addressing mission rationale, exploration objectives, and key constraints and issues facing human crews on Mars. The focal point was "why" the U.S. should fly humans to Mars. In the mid-1990s, strategies for a Mars mission matured and evolved, driven formally by NASA Johnson Space Center's Office of Exploration. In 1997, NASA published a report capturing the current thinking: the NASA Mars Reference Mission. In the 1997-1998 school year, HEDS-UP sponsored six universities to conduct design studies on Mars exploration, using the Reference Mission as a basis for their work. The 1998 Mars Exploration Forum presents the results of these university studies, suggesting "how" we might explore Mars, in terms of specific technical components that would enable human missions to Mars. A primary objective of the HEDS-UP Mars Exploration Forum was to provide a forum for active interaction among NASA, industry, and the university community on the subject of human missions to Mars. NASA scientists and engineers were asked to present the state of exploration for Mars mission options currently under study. This status "snapshot" of current Mars strategies set the stage for the six HEDS-UP universities to present their final design study results. Finally, a panel of industry experts discussed readiness for human missions to Mars as it pertains to the aerospace industries and technologies. A robust poster session provided the backdrop for government-industry-university discussions and allowed for feedback to NASA on the Mars Reference Mission. The common thread woven through the two days was discussion of technologies, proven and emerging, that will be required to launch, land, and sustain human crews on the Red Planet. As this decade (and indeed this millenium) draws to a close, Mars will continue to loom in our sights as the next target for human space exploration. It is our hope that the efforts of the Mars Exploration Forum will serve as one small contribution toward the ultimate goal of humans exploring Mars.

Reference Ranges for Serum Uric Acid among Healthy Assamese People

PubMed Central

Das, Madhumita; Borah, N. C.; Ghose, M.; Choudhury, N.

2014-01-01

This study was designed to establish reference ranges for serum uric acid among healthy adult Assamese population. Samples from 1470 aged 35–86 years were used to establish age and sex related reference range by the centile method (central 95 percentile) for serum uric acid level. There were 51% (n = 754) males and 49% (n = 716) females; 75.9% (n = 1115) of them were from urban area and the rest 24.1% (n = 355) were from the rural area. Majority of the population were nonvegetarian (98.6%, n = 1450) and only 1.4% (n = 20) were vegetarian. The mean age, weight, height, and uric acid of the studied group were 53.6 ± 11.3 years, 62.6 ± 10.5 kg, 160 ± 9.4 cm, and 5.5 ± 1.4 mg/dL, respectively. There is a statistically significant difference in the mean value of the abovementioned parameters between male and female. The observed reference range of uric acid in the population is 2.6–8.2 mg/dL which is wider than the current reference range used in the laboratory. Except gender (P < 0.0001), we did not find any significant relation of uric acid with other selected factors. PMID:24672726

Reference values of fractional excretion of exhaled nitric oxide among non-smokers and current smokers.

PubMed

Torén, Kjell; Murgia, Nicola; Schiöler, Linus; Bake, Björn; Olin, Anna-Carin

2017-08-25

Fractional exhaled nitric oxide (FE NO ) is used to assess of airway inflammation; diagnose asthma and monitor adherence to advised therapy. Reliable and accurate reference values for FE NO are needed for both non-smoking and current smoking adults in the clinical setting. The present study was performed to establish reference adult FE NO values among never-smokers, former smokers and current smokers. FE NO was measured in 5265 subjects aged 25-75 years in a general-population study, using a chemiluminescence (Niox ™) analyser according to the guidelines of the American Thoracic Society and the European Respiratory Society. Atopy was based on the presence of immunoglobulin E (IgE) antibodies to common inhalant allergens (measured using Phadiatop® test). Spirometry without bronchodilation was performed and forced vital capacity (FVC), forced expired volume in 1 s (FEV 1 ) and the ratio of FEV 1 to FVC values were obtained. After excluding subjects with asthma, chronic bronchitis, spirometric airway obstruction and current cold, 3378 subjects remained. Equations for predictions of FE NO values were modelled using nonparametric regression models. FE NO levels were similar in never-smokers and former smokers, and these two groups were therefore merged into a group termed "non-smokers". Reference equations, including the 5th and 95th percentiles, were generated for female and male non-smokers, based on age, height and atopy. Regression models for current smokers were unstable. Hence, the proposed reference values for current smokers are based on the univariate distribution of FE NO and fixed cut-off limits. Reference values for FE NO among respiratory healthy non-smokers should be outlined stratified for gender using individual reference values. For current smokers separate cut-off limits are proposed.

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

PubMed Central

Hart, Traver; Tong, Amy Hin Yan; Chan, Katie; Van Leeuwen, Jolanda; Seetharaman, Ashwin; Aregger, Michael; Chandrashekhar, Megha; Hustedt, Nicole; Seth, Sahil; Noonan, Avery; Habsid, Andrea; Sizova, Olga; Nedyalkova, Lyudmila; Climie, Ryan; Tworzyanski, Leanne; Lawson, Keith; Sartori, Maria Augusta; Alibeh, Sabriyeh; Tieu, David; Masud, Sanna; Mero, Patricia; Weiss, Alexander; Brown, Kevin R.; Usaj, Matej; Billmann, Maximilian; Rahman, Mahfuzur; Costanzo, Michael; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Durocher, Daniel; Moffat, Jason

2017-01-01

The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used to systematically create gene knockouts in a variety of human cancer and immortalized cell lines, in an effort to identify whether these knockouts cause cellular fitness defects. Previous work has shown that CRISPR screens are more sensitive and specific than pooled-library shRNA screens in similar assays, but currently there exists significant variability across CRISPR library designs and experimental protocols. In this study, we reanalyze 17 genome-scale knockout screens in human cell lines from three research groups, using three different genome-scale gRNA libraries. Using the Bayesian Analysis of Gene Essentiality algorithm to identify essential genes, we refine and expand our previously defined set of human core essential genes from 360 to 684 genes. We use this expanded set of reference core essential genes, CEG2, plus empirical data from six CRISPR knockout screens to guide the design of a sequence-optimized gRNA library, the Toronto KnockOut version 3.0 (TKOv3) library. We then demonstrate the high effectiveness of the library relative to reference sets of essential and nonessential genes, as well as other screens using similar approaches. The optimized TKOv3 library, combined with the CEG2 reference set, provide an efficient, highly optimized platform for performing and assessing gene knockout screens in human cell lines. PMID:28655737

System and method of detecting cavitation in pumps

DOEpatents

Lu, Bin; Sharma, Santosh Kumar; Yan, Ting; Dimino, Steven A.

2017-10-03

A system and method for detecting cavitation in pumps for fixed and variable supply frequency applications is disclosed. The system includes a controller having a processor programmed to repeatedly receive real-time operating current data from a motor driving a pump, generate a current frequency spectrum from the current data, and analyze current data within a pair of signature frequency bands of the current frequency spectrum. The processor is further programmed to repeatedly determine fault signatures as a function of the current data within the pair of signature frequency bands, repeatedly determine fault indices based on the fault signatures and a dynamic reference signature, compare the fault indices to a reference index, and identify a cavitation condition in a pump based on a comparison between the reference index and a current fault index.

Eddy current correction in volume-localized MR spectroscopy

NASA Technical Reports Server (NTRS)

Lin, C.; Wendt, R. E. 3rd; Evans, H. J.; Rowe, R. M.; Hedrick, T. D.; LeBlanc, A. D.

1994-01-01

The quality of volume-localized magnetic resonance spectroscopy is affected by eddy currents caused by gradient switching. Eddy currents can be reduced with improved gradient systems; however, it has been suggested that the distortion due to eddy currents can be compensated for during postprocessing with a single-frequency reference signal. The authors propose modifying current techniques for acquiring the single-frequency reference signal by using relaxation weighting to reduce interference from components that cannot be eliminated by digital filtering alone. Additional sequences with T1 or T2 weighting for reference signal acquisition are shown to have the same eddy current characteristics as the original signal without relaxation weighting. The authors also studied a new eddy current correction method that does not require a single-frequency reference signal. This method uses two free induction decays (FIDs) collected from the same volume with two sequences with opposite gradients. Phase errors caused by eddy currents are opposite in these two FIDs and can be canceled completely by combining the FIDs. These methods were tested in a phantom. Eddy current distortions were corrected, allowing quantitative measurement of structures such as the -CH = CH- component, which is otherwise undetectable.

Comparative study of reference currents and DC bus voltage control for Three-Phase Four-Wire Four-Leg SAPF to compensate harmonics and reactive power with 3D SVM.

PubMed

Chebabhi, A; Fellah, M K; Kessal, A; Benkhoris, M F

2015-07-01

In this paper the performances of three reference currents and DC bus voltage control techniques for Three-Phase Four-Wire Four-Leg SAPF are compared for balanced and unbalanced load conditions. The main goals are to minimize the harmonics, reduce the magnitude of neutral current, eliminate the zero-sequence current components caused by single-phase nonlinear loads and compensate the reactive power, and on the other hand improve performances such as robustness, stabilization, trajectory pursuit, and reduce time response. The three techniques are analyzed mathematically and simulation results are compared. The techniques considered for comparative study are the PI Control, Sliding Mode Control and the Backstepping Control. Synchronous reference frame theory (SRF) in the dqo-axes is used to generate the reference currents, of the inverter. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

A low temperature drift coefficient crystal-less frequency reference clock compensated by temperature sensor for microsystem

NASA Astrophysics Data System (ADS)

Gao, Zhiqiang; Wu, Ruixuan; Wang, Yuteng; Gao, Yuan; Liu, Xiaowei; Zhu, Jiaqi

2018-05-01

Quartz oscillator has been widely used as reference clock source in the microsystems due to its good performance. But a good crystal oscillator costs too much and its bulky size is not desired. This paper aims at designing an alternative integrated oscillator to replace the external quartz oscillator. The proposed circuit used maneatis delay cell to construct a ring oscillator for its superior linear I-V characteristic. As for a frequency reference clock, its frequency stability over temperature is required at first. After detailed mathematical deducing and careful analysis, a formula is proposed to describe the relationship between desired control voltage and temperature by assuming the frequency as constant. This paper utilized bipolar transistor as the temperature sensor, combining it with CTAT current source and resistor to create a first-order temperature compensation control voltage. The chip with typical frequency of 10 MHz was fabricated in a 0.35 μm CMOS technology and occupied 0.45 mm2. The measured results show that the frequency variation is ±0.2% for supply changes from 4.8 V to 5 V, and frequency variation is 48 ppm when the temperature change is from ‑40∘C to 85∘C, while the average current of the tested chip consumes 50 μA from 5 V.

A shift in referral patterns for HIV/AIDS patients.

PubMed

Fournier, Phillip O; Savageau, Judith A; Baldor, Robert A

2008-02-01

With the rapid development (and complex prescribing patterns) of drugs for HIV/AIDS care, it is challenging for physicians to keep current. We conducted a follow-up study to a 1994 cohort study to see how care and referral patterns have changed over the last decade. In this study, we examined how family physicians in Massachusetts were caring for their HIV-infected patients, and to see whether FPs were referring more patients to specialists for care compared with a decade ago. We designed a cross-sectional survey as an 11-year follow-up to a previous study. It was mailed in 2005 to the active membership of the Massachusetts Academy of Family Physicians. Compared with the cohort of 1994, the number of HIV+ patients in individual practices remained about the same, but the number of practices with no AIDS patients was significantly higher. 85.3% of FPs noted that they were more likely to refer HIV/AIDS patients immediately compared with their own practice patterns a decade ago. In this study, 39.0% of current respondents referred HIV+ patients immediately, 57.0% co-managed patients, and 4.1% managed these patients alone (the data for the 1994 cohort was 7.0%, 45.8%, and 47.2%, respectively; P<.0001). Similar changes were seen in regard to care patterns for AIDS patients. Among the current cohort, 61.7% reported that they referred patients immediately, compared with only 18.3% in 1994; 36.8% noted that they co-managed these patients (vs 74.3% in 1994); and only 1.5% reported that they managed these patients alone (vs 7.4% in 1994; P<.0001). A significant shift amongst FPs with regard to their referral patterns for patients with HIV/AIDS has occurred over the last decade. The community health center has emerged as a resource for patients with HIV/AIDS. Funding for specific training programs on HIV/AIDS care should be targeted to community health centers.

Toward best practice in Human Machine Interface design for older drivers: A review of current design guidelines.

PubMed

Young, K L; Koppel, S; Charlton, J L

2017-09-01

Older adults are the fastest growing segment of the driving population. While there is a strong emphasis for older people to maintain their mobility, the safety of older drivers is a serious community concern. Frailty and declines in a range of age-related sensory, cognitive, and physical impairments can place older drivers at an increased risk of crash-related injuries and death. A number of studies have indicated that in-vehicle technologies such as Advanced Driver Assistance Systems (ADAS) and In-Vehicle Information Systems (IVIS) may provide assistance to older drivers. However, these technologies will only benefit older drivers if their design is congruent with the complex needs and diverse abilities of this driving cohort. The design of ADAS and IVIS is largely informed by automotive Human Machine Interface (HMI) guidelines. However, it is unclear to what extent the declining sensory, cognitive and physical capabilities of older drivers are addressed in the current guidelines. This paper provides a review of key current design guidelines for IVIS and ADAS with respect to the extent they address age-related changes in functional capacities. The review revealed that most of the HMI guidelines do not address design issues related to older driver impairments. In fact, in many guidelines driver age and sensory cognitive and physical impairments are not mentioned at all and where reference is made, it is typically very broad. Prescriptive advice on how to actually design a system so that it addresses the needs and limitations of older drivers is not provided. In order for older drivers to reap the full benefits that in-vehicle technology can afford, it is critical that further work establish how older driver limitations and capabilities can be supported by the system design process, including their inclusion into HMI design guidelines. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins.

PubMed

Ast, Cindy; Foret, Jessica; Oltrogge, Luke M; De Michele, Roberto; Kleist, Thomas J; Ho, Cheng-Hsun; Frommer, Wolf B

2017-09-05

Sensitivity, dynamic and detection range as well as exclusion of expression and instrumental artifacts are critical for the quantitation of data obtained with fluorescent protein (FP)-based biosensors in vivo. Current biosensors designs are, in general, unable to simultaneously meet all these criteria. Here, we describe a generalizable platform to create dual-FP biosensors with large dynamic ranges by employing a single FP-cassette, named GO-(Green-Orange) Matryoshka. The cassette nests a stable reference FP (large Stokes shift LSSmOrange) within a reporter FP (circularly permuted green FP). GO- Matryoshka yields green and orange fluorescence upon blue excitation. As proof of concept, we converted existing, single-emission biosensors into a series of ratiometric calcium sensors (MatryoshCaMP6s) and ammonium transport activity sensors (AmTryoshka1;3). We additionally identified the internal acid-base equilibrium as a key determinant of the GCaMP dynamic range. Matryoshka technology promises flexibility in the design of a wide spectrum of ratiometric biosensors and expanded in vivo applications.Single fluorescent protein biosensors are susceptible to expression and instrumental artifacts. Here Ast et al. describe a dual fluorescent protein design whereby a reference fluorescent protein is nested within a reporter fluorescent protein to control for such artifacts while preserving sensitivity and dynamic range.

Evaluation of the effects of electric fields on implanted cardiac pacemakers. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, A.J.; Carstensen, E.

1985-02-01

The effects of extra high voltage (EHV) transmission line electric fields on pacemaker function were evaluated in 11 patients with seven different implanted pacemaker models from four manufacturers. Alteration in pacemaker function was demonstrated in five unipolar units (three different models) from two manufacturers during exposure to electric fields ranging from 2 to 9 kV/m, with total body currents from 47 to 175 ..mu..A. These electric fields and body currents are representative of values that can be encountered by individuals standing beneath EHV transmission lines. Transient alterations in pacemaker function observed in this study included inappropriate triggered activity, inhibition ofmore » impulse generation, reduction in rate, and reversion from demand to asynchronous mode. Electromagnetic interference from high voltage transmission lines can induce alterations in pacemaker function in certain designs of these devices. However, pacemaker manufacturers can incorporate appropriate circuits in the pacemaker design to eliminate this problem. 8 references.« less

Implantable and ingestible medical devices with wireless telemetry functionalities: a review of current status and challenges.

PubMed

Kiourti, Asimina; Psathas, Konstantinos A; Nikita, Konstantina S

2014-01-01

Wireless medical telemetry permits the measurement of physiological signals at a distance through wireless technologies. One of the latest applications is in the field of implantable and ingestible medical devices (IIMDs) with integrated antennas for wireless radiofrequency (RF) communication (telemetry) with exterior monitoring/control equipment. Implantable medical devices (MDs) perform an expanding variety of diagnostic and therapeutic functions, while ingestible MDs receive significant attention in gastrointestinal endoscopy. Design of such wireless IIMD telemetry systems is highly intriguing and deals with issues related to: operation frequency selection, electronics and powering, antenna design and performance, and modeling of the wireless channel. In this paper, we attempt to comparatively review the current status and challenges of IIMDs with wireless telemetry functionalities. Full solutions of commercial IIMDs are also recorded. The objective is to provide a comprehensive reference for scientists and developers in the field, while indicating directions for future research. © 2013 Wiley Periodicals, Inc.

The GOME-2 instrument on the Metop series of satellites: instrument design, calibration, and level 1 data processing - an overview

NASA Astrophysics Data System (ADS)

Munro, Rosemary; Lang, Rüdiger; Klaes, Dieter; Poli, Gabriele; Retscher, Christian; Lindstrot, Rasmus; Huckle, Roger; Lacan, Antoine; Grzegorski, Michael; Holdak, Andriy; Kokhanovsky, Alexander; Livschitz, Jakob; Eisinger, Michael

2016-03-01

The Global Ozone Monitoring Experiment-2 (GOME-2) flies on the Metop series of satellites, the space component of the EUMETSAT Polar System. In this paper we will provide an overview of the instrument design, the on-ground calibration and characterization activities, in-flight calibration, and level 0 to 1 data processing. The current status of the level 1 data is presented and points of specific relevance to users are highlighted. Long-term level 1 data consistency is also discussed and plans for future work are outlined. The information contained in this paper summarizes a large number of technical reports and related documents containing information that is not currently available in the published literature. These reports and documents are however made available on the EUMETSAT web pages and readers requiring more details than can be provided in this overview paper will find appropriate references at relevant points in the text.

Resource Conservation and Recovery Act, Part B Permit Application [for the Waste Isolation Pilot Plant (WIPP)]. Volume 5, Chapter D, Appendix D1 (conclusion), Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, Neville G.W.; Heuze, Francois E.; Miller, Hamish D.S.

1993-03-01

The reference design for the underground facilities at the Waste Isolation Pilot Plant was developed using the best criteria available at initiation of the detailed design effort. These design criteria are contained in the US Department of Energy document titled Design Criteria, Waste Isolation Pilot Plant (WIPP). Revised Mission Concept-IIA (RMC-IIA), Rev. 4, dated February 1984. The validation process described in the Design Validation Final Report has resulted in validation of the reference design of the underground openings based on these criteria. Future changes may necessitate modification of the Design Criteria document and/or the reference design. Validation of the referencemore » design as presented in this report permits the consideration of future design or design criteria modifications necessitated by these changes or by experience gained at the WIPP. Any future modifications to the design criteria and/or the reference design will be governed by a DOE Standard Operation Procedure (SOP) covering underground design changes. This procedure will explain the process to be followed in describing, evaluating and approving the change.« less

Optical Design Trade Study for the Wide Field Infrared Survey Telescope [WFIRST

NASA Technical Reports Server (NTRS)

Content, David A.; Goullioud, R.; Lehan, John P.; Mentzell, John E.

2011-01-01

The Wide Field Infrared Survey Telescope (WFIRST) mission concept was ranked first in new space astrophysics mission by the Astro2010 Decadal Survey incorporating the Joint Dark Energy Mission (JDEM)-Omega payload concept and multiple science white papers. This mission is based on a space telescope at L2 studying exoplanets [via gravitational microlensing], probing dark energy, and surveying the near infrared sky. Since the release of NWNH, the WFIRST project has been working with the WFIRST science definition team (SDT) to refine mission and payload concepts. We present the driving requirements. The current interim reference mission point design, based on the use of a 1.3m unobscured aperture three mirror anastigmat form, with focal imaging and slitless spectroscopy science channels, is consistent with the requirements, requires no technology development, and out performs the JDEM-Omega design.

Practical experience with graphical user interfaces and object-oriented design in the clinical laboratory.

PubMed

Wells, I G; Cartwright, R Y; Farnan, L P

1993-12-15

The computing strategy in our laboratories evolved from research in Artificial Intelligence, and is based on powerful software tools running on high performance desktop computers with a graphical user interface. This allows most tasks to be regarded as design problems rather than implementation projects, and both rapid prototyping and an object-oriented approach to be employed during the in-house development and enhancement of the laboratory information systems. The practical application of this strategy is discussed, with particular reference to the system designer, the laboratory user and the laboratory customer. Routine operation covers five departments, and the systems are stable, flexible and well accepted by the users. Client-server computing, currently undergoing final trials, is seen as the key to further development, and this approach to Pathology computing has considerable potential for the future.

Design and analysis of an electromagnetic turnout for the superconducting Maglev system

NASA Astrophysics Data System (ADS)

Li, Y. J.; Dai, Q.; Zhang, Y.; Wang, H.; Chen, Z.; Sun, R. X.; Zheng, J.; Deng, C. Y.; Deng, Z. G.

2016-09-01

Turnout is a crucial track junction device of the ground rail transportation system. For high temperature superconducting (HTS) Maglev system, the permanent magnet guideway (PMG) makes the strong magnetic force existing between rail segments, which may cause moving difficulties and increase the operation cost when switching a PMG. In this paper, a non-mechanical 'Y' shaped Halbach-type electromagnetic turnout was proposed. By replacing the PMs with electromagnets, the turnout can guide the maglev vehicle running into another PMG by simply controlling the current direction of electromagnets. The material and structure parameters of the electromagnets were optimized by simulation. The results show that the optimized electromagnet can keep the magnetic field above it as strong as the PMs', meanwhile feasible for design and manufacture. This work provides valuable references for the future design in non-mechanical PMG turnout.

Variations of transcript profiles between sea otters Enhydra lutris from Prince William Sound, Alaska, and clinically normal reference otters

USGS Publications Warehouse

Miles, A. Keith; Bowen, Lizabeth; Ballachey, Brenda E.; Bodkin, James L.; Murray, M.; Estes, J.L.; Keister, Robin A.; Stott, J.L.

2012-01-01

Development of blood leukocyte gene transcript profiles has the potential to expand condition assessments beyond those currently available to evaluate wildlife health, including sea otters Enhydra lutris, both individually and as populations. The 10 genes targeted in our study represent multiple physiological systems that play a role in immuno-modulation, inflammation, cell protection, tumor suppression, cellular stress-response, xenobiotic metabolizing enzymes, and antioxidant enzymes. These genes can be modified by biological, physical, or anthropogenic impacts and consequently provide information on the general type of stressors present in a given environment. We compared gene transcript profiles of sea otters sampled in 2008 among areas within Prince William Sound impacted to varying degrees by the 1989 ‘Exxon Valdez’ oil spill with those of captive and wild reference sea otters. Profiles of sea otters from Prince William Sound showed elevated transcription in genes associated with tumor formation, cell death, organic exposure, inflammation, and viral exposure when compared to the reference sea otter group, indicating possible recent and chronic exposure to organic contaminants. Sea otters from historically designated oiled areas within Prince William Sound 19 yr after the oil spill had higher transcription of genes associated with tumor formation, cell death, heat shock, and inflammation than those from areas designated as less impacted by the spill.

77 FR 36727 - Endangered and Threatened Wildlife and Plants; Revised Designation of Critical Habitat for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

...We, the U.S. Fish and Wildlife Service (Service), designate revised critical habitat for the Pacific Coast distinct population segment (DPS) (Pacific Coast WSP) of the western snowy plover (Charadrius nivosus nivosus, formerly C. alexandrinus nivosus) under the Endangered Species Act of 1973, as amended (Act). In total, approximately 24,527 acres (9,926 hectares) of critical habitat for the Pacific Coast WSP in Washington, Oregon, and California, fall within the boundaries of the critical habitat designation. This revised final designation constitutes an increase of approximately 12,377 ac (5,009 ha) from the 2005 designation of critical habitat for the Pacific Coast WSP. A taxonomic name change has occurred and been accepted for the snowy plover. Throughout the remainder of this document, we will use the currently recognized name for the subspecies, Charadrius nivosus nivosus, to which the listed entity (Pacific Coast WSP) belongs for references to the Pacific Coast WSP.

Engaging teenagers productively in service design

PubMed Central

Bowen, Simon; Sustar, Helena; Wolstenholme, Daniel; Dearden, Andy

2013-01-01

Engaging young people in participatory design can be challenging, particularly in health-related projects. In a study co-designing diabetes support and information services with teenagers, we found framing activities using popular culture was a useful strategy. Various cultural references helped us stage activities that were productive for the design process, and were engaging for our young participants (e.g. exploring practical implications through discussions in a ‘Dragons’ Den’). Some activities were more effective than others and the idea of language-games, which has been widely explored in participatory design, explains why our strategy was successful when there was a clear ‘family resemblance’ between the popular cultural references and certain essential stages of designing. However, attention is required in selecting appropriate cultural references if this strategy is adopted elsewhere, and design facilitators should focus first on devising accessible language-games, rather than expecting popular cultural references to provide complete solutions to the challenge of staging participatory design. PMID:26516621

Forget the Desk Job: Current Roles and Responsibilities in Entry-Level Reference Job Advertisements

ERIC Educational Resources Information Center

Detmering, Robert; Sproles, Claudene

2012-01-01

This study examines the evolving roles and responsibilities of entry-level academic reference positions, as stated in recent job advertisements posted on the American Library Association's JobLIST Web site and other sources. Findings from a content analysis of these advertisements indicate that current entry-level reference positions in academic…

Evaluation of local electric fields generated by transcranial direct current stimulation with an extracephalic reference electrode based on realistic 3D body modeling

NASA Astrophysics Data System (ADS)

Im, Chang-Hwan; Park, Ji-Hye; Shim, Miseon; Chang, Won Hyuk; Kim, Yun-Hee

2012-04-01

In this study, local electric field distributions generated by transcranial direct current stimulation (tDCS) with an extracephalic reference electrode were evaluated to address extracephalic tDCS safety issues. To this aim, we generated a numerical model of an adult male human upper body and applied the 3D finite element method to electric current conduction analysis. In our simulations, the active electrode was placed over the left primary motor cortex (M1) and the reference electrode was placed at six different locations: over the right temporal lobe, on the right supraorbital region, on the right deltoid, on the left deltoid, under the chin, and on the right buccinator muscle. The maximum current density and electric field intensity values in the brainstem generated by the extracephalic reference electrodes were comparable to, or even less than, those generated by the cephalic reference electrodes. These results suggest that extracephalic reference electrodes do not lead to unwanted modulation of the brainstem cardio-respiratory and autonomic centers, as indicated by recent experimental studies. The volume energy density was concentrated at the neck area by the use of deltoid reference electrodes, but was still smaller than that around the active electrode locations. In addition, the distributions of elicited cortical electric fields demonstrated that the use of extracephalic reference electrodes might allow for the robust prediction of cortical modulations with little dependence on the reference electrode locations.

Foundations of teamwork and collaboration.

PubMed

Driskell, James E; Salas, Eduardo; Driskell, Tripp

2018-01-01

The term teamwork has graced countless motivational posters and office walls. However, although teamwork is often easy to observe, it is somewhat more difficult to describe and yet more difficult to produce. At a broad level, teamwork is the process through which team members collaborate to achieve task goals. Teamwork refers to the activities through which team inputs translate into team outputs such as team effectiveness and satisfaction. In this article, we describe foundational research underlying current research on teamwork. We examine the evolution of team process models and outline primary teamwork dimensions. We discuss selection, training, and design approaches to enhancing teamwork, and note current applications of teamwork research in real-world settings. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Effect of Pulse Rate on Loudness Discrimination in Cochlear Implant Users.

PubMed

Azadpour, Mahan; McKay, Colette M; Svirsky, Mario A

2018-03-12

Stimulation pulse rate affects current amplitude discrimination by cochlear implant (CI) users, indicated by the evidence that the JND (just noticeable difference) in current amplitude delivered by a CI electrode becomes larger at higher pulse rates. However, it is not clearly understood whether pulse rate would affect discrimination of speech intensities presented acoustically to CI processors, or what the size of this effect might be. Intensity discrimination depends on two factors: the growth of loudness with increasing sound intensity and the loudness JND (or the just noticeable loudness increment). This study evaluated the hypothesis that stimulation pulse rate affects loudness JND. This was done by measuring current amplitude JNDs in an experiment design based on signal detection theory according to which loudness discrimination is related to internal noise (which is manifested by variability in loudness percept in response to repetitions of the same physical stimulus). Current amplitude JNDs were measured for equally loud pulse trains of 500 and 3000 pps (pulses per second) by increasing the current amplitude of the target pulse train until it was perceived just louder than a same-rate or different-rate reference pulse train. The JND measures were obtained at two presentation levels. At the louder level, the current amplitude JNDs were affected by the rate of the reference pulse train in a way that was consistent with greater noise or variability in loudness perception for the higher pulse rate. The results suggest that increasing pulse rate from 500 to 3000 pps can increase loudness JND by 60 % at the upper portion of the dynamic range. This is equivalent to a 38 % reduction in the number of discriminable steps for acoustic and speech intensities.

Safeguards and Security by Design (SSBD) for Small Modular Reactors (SMRs) through a Common Global Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Badwan, Faris M.; Demuth, Scott Francis; Miller, Michael Conrad

Small Modular Reactors (SMR) with power levels significantly less than the currently standard 1000 to 1600-MWe reactors have been proposed as a potential game changer for future nuclear power. SMRs may offer a simpler, more standardized, and safer modular design by using factory built and easily transportable components. Additionally, SMRs may be more easily built and operated in isolated locations, and may require smaller initial capital investment and shorter construction times. Because many SMRs designs are still conceptual and consequently not yet fixed, designers have a unique opportunity to incorporate updated design basis threats, emergency preparedness requirements, and then fullymore » integrate safety, physical security, and safeguards/material control and accounting (MC&A) designs. Integrating safety, physical security, and safeguards is often referred to as integrating the 3Ss, and early consideration of safeguards and security in the design is often referred to as safeguards and security by design (SSBD). This paper describes U.S./Russian collaborative efforts toward developing an internationally accepted common approach for implementing SSBD/3Ss for SMRs based upon domestic requirements, and international guidance and requirements. These collaborative efforts originated with the Nuclear Energy and Nuclear Security working group established under the U.S.-Russia Bilateral Presidential Commission during the 2009 Presidential Summit. Initial efforts have focused on review of U.S. and Russian domestic requirements for Security and MC&A, IAEA guidance for security and MC&A, and IAEA requirements for international safeguards. Additionally, example SMR design features that can enhance proliferation resistance and physical security have been collected from past work and reported here. The development of a U.S./Russian common approach for SSBD/3Ss should aid the designer of SMRs located anywhere in the world. More specifically, the application of this approach may lead to more proliferation resistant and physically secure design features for SMRs.« less

Sensorless H∞ speed-tracking synthesis for surface-mount permanent magnet synchronous motor.

PubMed

Ramírez-Villalobos, Ramón; Aguilar, Luis T; Coria, Luis N

2017-03-01

In this paper, a sensorless speed tracking control is proposed for a surface-mount permanent magnet synchronous motor by using a nonlinear H ∞ -controller via stator currents measurements for feedback. An output feedback nonlinear H ∞ -controller was designed such that the undisturbed system is uniformly asymptotically stable around the desired speed reference, while also the effects of external vanishing and non-vanishing disturbances, noise, and input backlash were attenuated locally. The rotor position was calculated from the causal dynamic output feedback compensator and from the desired speed reference. The existence of the proper solutions of the perturbed differential Riccati equations ensures stabilizability and detectability of the control system. The efficiency of the proposed sensorless controller was supported by numerical simulations. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Electrophysiological Responses to Expectancy Violations in Semantic and Gambling Tasks: A Comparison of Different EEG Reference Approaches

PubMed Central

Li, Ya; Wang, Yongchun; Zhang, Baoqiang; Wang, Yonghui; Zhou, Xiaolin

2018-01-01

Dynamically evaluating the outcomes of our actions and thoughts is a fundamental cognitive ability. Given its excellent temporal resolution, the event-related potential (ERP) technology has been used to address this issue. The feedback-related negativity (FRN) component of ERPs has been studied intensively with the averaged linked mastoid reference method (LM). However, it is unknown whether FRN can be induced by an expectancy violation in an antonym relations context and whether LM is the most suitable reference approach. To address these issues, the current research directly compared the ERP components induced by expectancy violations in antonym expectation and gambling tasks with a within-subjects design and investigated the effect of the reference approach on the experimental effects. Specifically, we systematically compared the influence of the LM, reference electrode standardization technique (REST) and average reference (AVE) approaches on the amplitude, scalp distribution and magnitude of ERP effects as a function of expectancy violation type. The expectancy deviation in the antonym expectation task elicited an N400 effect that differed from the FRN effect induced in the gambling task; this difference was confirmed by all the three reference methods. Both the amplitudes of the ERP effects (N400 and FRN) and the magnitude as the expectancy violation increased were greater under the LM approach than those under the REST approach, followed by those under the AVE approach. Based on the statistical results, the electrode sites that showed the N400 and FRN effects critically depended on the reference method, and the results of the REST analysis were consistent with previous ERP studies. Combined with evidence from simulation studies, we suggest that REST is an optional reference method to be used in future ERP data analysis. PMID:29615858

A study to evaluate STS heads-up ascent trajectory performance employing a minimum-Hamiltonian optimization strategy

NASA Technical Reports Server (NTRS)

Sinha, Sujit

1988-01-01

A study was conducted to evaluate the performance implications of a heads-up ascent flight design for the Space Transportation System, as compared to the current heads-down flight mode. The procedure involved the use of the Minimum Hamiltonian Ascent Shuttle Trajectory Evaluation Program, which is a three-degree-of-freedom moment balance simulation of shuttle ascent. A minimum-Hamiltonian optimization strategy was employed to maximize injection weight as a function of maximum dynamic pressure constraint and Solid Rocket Motor burnrate. Performance Reference Mission Four trajectory groundrules were used for consistency. The major conclusions are that for heads-up ascent and a mission nominal design maximum dynamic pressure value of 680 psf, the optimum solid motor burnrate is 0.394 ips, which produces a performance enhancement of 4293 lbm relative to the baseline heads-down ascent, with 0.368 ips burnrate solid motors and a 680 psf dynamic pressure constraint. However, no performance advantage exists for heads-up flight if the current Solid Rocket Motor target burnrate of 0.368 ips is used. The advantage of heads-up ascent flight employing the current burnrate is that Space Shuttle Main Engine throttling for dynamic pressure control is not necessary.

40 CFR 53.11 - Cancellation of reference or equivalent method designation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Cancellation of reference or equivalent method designation. 53.11 Section 53.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) AMBIENT AIR MONITORING REFERENCE AND EQUIVALENT METHODS General...

CDRD and PNPR satellite passive microwave precipitation retrieval algorithms: EuroTRMM/EURAINSAT origins and H-SAF operations

NASA Astrophysics Data System (ADS)

Mugnai, A.; Smith, E. A.; Tripoli, G. J.; Bizzarri, B.; Casella, D.; Dietrich, S.; Di Paola, F.; Panegrossi, G.; Sanò, P.

2013-04-01

Satellite Application Facility on Support to Operational Hydrology and Water Management (H-SAF) is a EUMETSAT (European Organisation for the Exploitation of Meteorological Satellites) program, designed to deliver satellite products of hydrological interest (precipitation, soil moisture and snow parameters) over the European and Mediterranean region to research and operations users worldwide. Six satellite precipitation algorithms and concomitant precipitation products are the responsibility of various agencies in Italy. Two of these algorithms have been designed for maximum accuracy by restricting their inputs to measurements from conical and cross-track scanning passive microwave (PMW) radiometers mounted on various low Earth orbiting satellites. They have been developed at the Italian National Research Council/Institute of Atmospheric Sciences and Climate in Rome (CNR/ISAC-Rome), and are providing operational retrievals of surface rain rate and its phase properties. Each of these algorithms is physically based, however, the first of these, referred to as the Cloud Dynamics and Radiation Database (CDRD) algorithm, uses a Bayesian-based solution solver, while the second, referred to as the PMW Neural-net Precipitation Retrieval (PNPR) algorithm, uses a neural network-based solution solver. Herein we first provide an overview of the two initial EU research and applications programs that motivated their initial development, EuroTRMM and EURAINSAT (European Satellite Rainfall Analysis and Monitoring at the Geostationary Scale), and the current H-SAF program that provides the framework for their operational use and continued development. We stress the relevance of the CDRD and PNPR algorithms and their precipitation products in helping secure the goals of H-SAF's scientific and operations agenda, the former helpful as a secondary calibration reference to other algorithms in H-SAF's complete mix of algorithms. Descriptions of the algorithms' designs are provided including a few examples of their performance. This aspect of the development of the two algorithms is placed in the context of what we refer to as the TRMM era, which is the era denoting the active and ongoing period of the Tropical Rainfall Measuring Mission (TRMM) that helped inspire their original development. In 2015, the ISAC-Rome precipitation algorithms will undergo a transformation beginning with the upcoming Global Precipitation Measurement (GPM) mission, particularly the GPM Core Satellite technologies. A few years afterward, the first pair of imaging and sounding Meteosat Third Generation (MTG) satellites will be launched, providing additional technological advances. Various of the opportunities presented by the GPM Core and MTG satellites for improving the current CDRD and PNPR precipitation retrieval algorithms, as well as extending their product capability, are discussed.

Temperature compensated and self-calibrated current sensor using reference magnetic field

DOEpatents

Yakymyshyn, Christopher Paul; Brubaker, Michael Allen; Yakymyshyn, Pamela Jane

2007-10-09

A method is described to provide temperature compensation and self-calibration of a current sensor based on a plurality of magnetic field sensors positioned around a current carrying conductor. A reference magnetic field generated within the current sensor housing is detected by the magnetic field sensors and is used to correct variations in the output signal due to temperature variations and aging.

Temperature compensated current sensor using reference magnetic field

DOEpatents

Yakymyshyn, Christopher Paul; Brubaker, Michael Allen; Yakymyshyn, Pamela Jane

2007-10-09

A method is described to provide temperature compensation and self-calibration of a current sensor based on a plurality of magnetic field sensors positioned around a current carrying conductor. A reference magnetic field generated within the current sensor housing is detected by a separate but identical magnetic field sensor and is used to correct variations in the output signal due to temperature variations and aging.

Hybrid Nanoparticles for Detection and Treatment of Cancer

PubMed Central

Sailor, Michael J.; Park, Ji-Ho

2012-01-01

There is currently considerable effort to incorporate both diagnostic and therapeutic functions into a single nanoscale system for the more effective treatment of cancer. Nanoparticles have great potential to achieve such dual functions, particularly if more than one type of nanostructure can be incorporated in a nanoassembly—referred to in this review as a hybrid nanoparticle. Here we review recent developments in the synthesis and evaluation of such hybrid nanoparticles based on two design strategies (barge vs. tanker), in which liposomal, micellar, porous silica, polymeric, viral, noble metal, and nanotube systems are incorporated either within (barge) or at the surface of (tanker) a nanoparticle. We highlight the design factors that should be considered to obtain effective nanodevices for cancer detection and treatment. PMID:22610698

Development of a microcomputer-based magnetic heading sensor

NASA Technical Reports Server (NTRS)

Garner, H. D.

1987-01-01

This paper explores the development of a flux-gate magnetic heading reference using a single-chip microcomputer to process heading information and to present it to the pilot in appropriate form. This instrument is intended to replace the conventional combination of mechanical compass and directional gyroscope currently in use in general aviation aircraft, at appreciable savings in cost and reduction in maintenance. Design of the sensing element, the signal processing electronics, and the computer algorithms which calculate the magnetic heading of the aircraft from the magnetometer data have been integrated in such a way as to minimize hardware requirements and simplify calibration procedures. Damping and deviation errors are avoided by the inherent design of the device, and a technique for compensating for northerly-turning-error is described.

Morphometric Analysis of the Clavicles in Chinese Population

PubMed Central

Yang, Jesse Chieh-Szu; Lin, Kang-Ping

2017-01-01

The clavicle has a complex geometry that makes plate fixation technically difficult. The current study aims to measure the anatomical parameters of Chinese clavicles as reference for plate design. One hundred clavicles were analyzed. The clavicle bone model was reconstructed by using computed tomography images. The length, diameters, and curvatures of the clavicle were then measured. The female clavicle was shorter, more slender, and less curved in lateral part than the male clavicle. There was a positive relationship between height and clavicle parameters except lateral curve and depth. The measurements of Chinese clavicles were generally smaller than Caucasians. The clavicle curves were correlated with the bone length; thus consideration of the curve variations may be necessary as designing size distribution of clavicle plate. PMID:28497066

The new Langley Research Center advanced real-time simulation (ARTS) system

NASA Technical Reports Server (NTRS)

Crawford, D. J.; Cleveland, J. I., II

1986-01-01

Based on a survey of current local area network technology with special attention paid to high bandwidth and very low transport delay requirements, NASA's Langley Research Center designed a new simulation subsystem using the computer automated measurement and control (CAMAC) network. This required significant modifications to the standard CAMAC system and development of a network switch, a clocking system, new conversion equipment, new consoles, supporting software, etc. This system is referred to as the advanced real-time simulation (ARTS) system. It is presently being built at LaRC. This paper provides a functional and physical description of the hardware and a functional description of the software. The requirements which drove the design are presented as well as present performance figures and status.

Selection of reference genes for quantitative gene expression normalization in flax (Linum usitatissimum L.).

PubMed

Huis, Rudy; Hawkins, Simon; Neutelings, Godfrey

2010-04-19

Quantitative real-time PCR (qRT-PCR) is currently the most accurate method for detecting differential gene expression. Such an approach depends on the identification of uniformly expressed 'housekeeping genes' (HKGs). Extensive transcriptomic data mining and experimental validation in different model plants have shown that the reliability of these endogenous controls can be influenced by the plant species, growth conditions and organs/tissues examined. It is therefore important to identify the best reference genes to use in each biological system before using qRT-PCR to investigate differential gene expression. In this paper we evaluate different candidate HKGs for developmental transcriptomic studies in the economically-important flax fiber- and oil-crop (Linum usitatissimum L). Specific primers were designed in order to quantify the expression levels of 20 different potential housekeeping genes in flax roots, internal- and external-stem tissues, leaves and flowers at different developmental stages. After calculations of PCR efficiencies, 13 HKGs were retained and their expression stabilities evaluated by the computer algorithms geNorm and NormFinder. According to geNorm, 2 Transcriptional Elongation Factors (TEFs) and 1 Ubiquitin gene are necessary for normalizing gene expression when all studied samples are considered. However, only 2 TEFs are required for normalizing expression in stem tissues. In contrast, NormFinder identified glyceraldehyde-3-phosphate dehydrogenase (GADPH) as the most stably expressed gene when all samples were grouped together, as well as when samples were classed into different sub-groups.qRT-PCR was then used to investigate the relative expression levels of two splice variants of the flax LuMYB1 gene (homologue of AtMYB59). LuMYB1-1 and LuMYB1-2 were highly expressed in the internal stem tissues as compared to outer stem tissues and other samples. This result was confirmed with both geNorm-designated- and NormFinder-designated-reference genes. The use of 2 different statistical algorithms results in the identification of different combinations of flax HKGs for expression data normalization. Despite such differences, the use of geNorm-designated- and NormFinder-designated-reference genes enabled us to accurately compare the expression levels of a flax MYB gene in different organs and tissues. Our identification and validation of suitable flax HKGs will facilitate future developmental transcriptomic studies in this economically-important plant.

Serum TSH reference interval in healthy Finnish adults using the Abbott Architect 2000i Analyzer.

PubMed

Schalin-Jäntti, Camilla; Tanner, Pirjo; Välimäki, Matti J; Hämäläinen, Esa

2011-07-01

Current serum TSH reference intervals have been criticized as they were established from unselected background populations. A special concern is that the upper limit, which defines subclinical hypothyroidism, is too high. The objective was to redefine the TSH reference interval in the adult Finnish population. The current reference interval for the widely used Abbott Architect method in Finland is 0.4-4.0 mU/L. Serum TSH and free T4 concentrations were derived from 606 healthy, non-pregnant, 18-91-year-old Finns from the Nordic Reference Interval Project (NORIP) and the possible effects of age, sex and thyroid peroxidase antibody (TPOAb) status were evaluated. After excluding TPOAb-positive subjects and outliers, a reference population of 511 subjects was obtained. In the reference population, no statistically significant gender- or age-specific differences in mean TSH (1.55 ± 3.30 mU/L) or TSH reference intervals were observed. The new reference interval was 0.5-3.6 mU/L (2.5th-97.5th percentiles). The current upper TSH reference limit is 10% too high. A TSH > 3.6 mU/L, confirmed with a repeat TSH sampling, may indicate subclinical hypothyroidism. Differences in ethnicity, regional iodine-intake and analytical methods underline the need for redefining the TSH reference interval in central laboratories in different countries.

Current level detector

DOEpatents

Kerns, Cordon R.

1977-01-01

A device is provided for detecting the current level of a DC signal. It includes an even harmonic modulator to which a reference AC signal is applied. The unknown DC signal acts on the reference AC signal so that the output of the modulator includes an even harmonic whose amplitude is proportional to the unknown DC current.

40 CFR 53.8 - Designation of reference and equivalent methods.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Designation of reference and equivalent methods. 53.8 Section 53.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) AMBIENT AIR MONITORING REFERENCE AND EQUIVALENT METHODS General Provisions § 53.8...

Control Activity in Support of NASA Turbine Based Combined Cycle (TBCC) Research

NASA Technical Reports Server (NTRS)

Stueber, Thomas J.; Vrnak, Daniel R.; Le, Dzu K.; Ouzts, Peter J.

2010-01-01

Control research for a Turbine Based Combined Cycle (TBCC) propulsion system is the current focus of the Hypersonic Guidance, Navigation, and Control (GN&C) discipline team. The ongoing work at the NASA Glenn Research Center (GRC) supports the Hypersonic GN&C effort in developing tools to aid the design of control algorithms to manage a TBCC airbreathing propulsion system during a critical operating period. The critical operating period being addressed in this paper is the span when the propulsion system transitions from one cycle to another, referred to as mode transition. One such tool, that is a basic need for control system design activities, is computational models (hereto forth referred to as models) of the propulsion system. The models of interest for designing and testing controllers are Control Development Models (CDMs) and Control Validation Models (CVMs). CDMs and CVMs are needed for each of the following propulsion system elements: inlet, turbine engine, ram/scram dual-mode combustor, and nozzle. This paper presents an overall architecture for a TBCC propulsion system model that includes all of the propulsion system elements. Efforts are under way, focusing on one of the propulsion system elements, to develop CDMs and CVMs for a TBCC propulsion system inlet. The TBCC inlet aerodynamic design being modeled is that of the Combined-Cycle Engine (CCE) Testbed. The CCE Testbed is a large-scale model of an aerodynamic design that was verified in a small-scale screening experiment. The modeling approach includes employing existing state-of-the-art simulation codes, developing new dynamic simulations, and performing system identification experiments on the hardware in the NASA GRC 10 by10-Foot Supersonic Wind Tunnel. The developed CDMs and CVMs will be available for control studies prior to hardware buildup. The system identification experiments on the CCE Testbed will characterize the necessary dynamics to be represented in CDMs for control design. These system identification models will also be the reference models to validate the CDM and CVM models. Validated models will give value to the tools used to develop the models.

Improved power control using optimal adjustable coefficients for three-phase photovoltaic inverter under unbalanced grid voltage.

PubMed

Wang, Qianggang; Zhou, Niancheng; Lou, Xiaoxuan; Chen, Xu

2014-01-01

Unbalanced grid faults will lead to several drawbacks in the output power quality of photovoltaic generation (PV) converters, such as power fluctuation, current amplitude swell, and a large quantity of harmonics. The aim of this paper is to propose a flexible AC current generation method by selecting coefficients to overcome these problems in an optimal way. Three coefficients are brought in to tune the output current reference within the required limits of the power quality (the current harmonic distortion, the AC current peak, the power fluctuation, and the DC voltage fluctuation). Through the optimization algorithm, the coefficients can be determined aiming to generate the minimum integrated amplitudes of the active and reactive power references with the constraints of the inverter current and DC voltage fluctuation. Dead-beat controller is utilized to track the optimal current reference in a short period. The method has been verified in PSCAD/EMTDC software.

Improved Power Control Using Optimal Adjustable Coefficients for Three-Phase Photovoltaic Inverter under Unbalanced Grid Voltage

PubMed Central

Wang, Qianggang; Zhou, Niancheng; Lou, Xiaoxuan; Chen, Xu

2014-01-01

Unbalanced grid faults will lead to several drawbacks in the output power quality of photovoltaic generation (PV) converters, such as power fluctuation, current amplitude swell, and a large quantity of harmonics. The aim of this paper is to propose a flexible AC current generation method by selecting coefficients to overcome these problems in an optimal way. Three coefficients are brought in to tune the output current reference within the required limits of the power quality (the current harmonic distortion, the AC current peak, the power fluctuation, and the DC voltage fluctuation). Through the optimization algorithm, the coefficients can be determined aiming to generate the minimum integrated amplitudes of the active and reactive power references with the constraints of the inverter current and DC voltage fluctuation. Dead-beat controller is utilized to track the optimal current reference in a short period. The method has been verified in PSCAD/EMTDC software. PMID:25243215

Disseminating research findings: what should researchers do? A systematic scoping review of conceptual frameworks

PubMed Central

2010-01-01

Background Addressing deficiencies in the dissemination and transfer of research-based knowledge into routine clinical practice is high on the policy agenda both in the UK and internationally. However, there is lack of clarity between funding agencies as to what represents dissemination. Moreover, the expectations and guidance provided to researchers vary from one agency to another. Against this background, we performed a systematic scoping to identify and describe any conceptual/organising frameworks that could be used by researchers to guide their dissemination activity. Methods We searched twelve electronic databases (including MEDLINE, EMBASE, CINAHL, and PsycINFO), the reference lists of included studies and of individual funding agency websites to identify potential studies for inclusion. To be included, papers had to present an explicit framework or plan either designed for use by researchers or that could be used to guide dissemination activity. Papers which mentioned dissemination (but did not provide any detail) in the context of a wider knowledge translation framework, were excluded. References were screened independently by at least two reviewers; disagreements were resolved by discussion. For each included paper, the source, the date of publication, a description of the main elements of the framework, and whether there was any implicit/explicit reference to theory were extracted. A narrative synthesis was undertaken. Results Thirty-three frameworks met our inclusion criteria, 20 of which were designed to be used by researchers to guide their dissemination activities. Twenty-eight included frameworks were underpinned at least in part by one or more of three different theoretical approaches, namely persuasive communication, diffusion of innovations theory, and social marketing. Conclusions There are currently a number of theoretically-informed frameworks available to researchers that can be used to help guide their dissemination planning and activity. Given the current emphasis on enhancing the uptake of knowledge about the effects of interventions into routine practice, funders could consider encouraging researchers to adopt a theoretically-informed approach to their research dissemination. PMID:21092164

The ``Leakage Current Sentinel'': A novel plug-in socket device for online biomedical equipment electrical safety surveillance

NASA Astrophysics Data System (ADS)

Cappa, Paolo; Marinozzi, Franco; Sciuto, Salvatore Andrea

2000-07-01

The Leakage Current Sentinel (LCS) has been designed and implemented for the detection of hazardous situations caused by dangerous earth leakage current values in intensive care units and operating theaters. The device, designed and manufactured with full compliance of the high risk environment requirements, is able to monitor online the earth leakage current and detect ground wire faults. Operation utilizes a microammeter with an overall sensitivity of 2.5×104 V/A. In order to assure the reliability of the device in providing alarm signals, the simultaneous presence of absorbed power current is monitored by means of another ammeter with decreased sensitivity (3.0 V/A). The measured root mean square current values are compared with reference values in order to send signals to NAND and OR complementary metal-oxide-semiconductor gates to enable audible and visible alarms according to the possible hazardous cases examined in the article. The final LCS packaging was shaped as a wall socket adapter for common electromedical device power cord plugs, with particular attention to minimizing its dimensions and to provide analog voltage outputs for both measured leakage and power currents, in order to allow automatic data acquisition and computerized hazardous situation management. Finally, a personal computer based automatic measuring system has been configured to simultaneously monitor several LCSs installed in the same intensive care unit room and, as a consequence, to distinguish different hazardous scenarios and provide an adequate alert to the clinical personnel whose final decision is still required. The test results confirm the effectiveness and reliability of the LCS in giving an alert in case of leakage current anomalous values, either in case of a ground fault or in case of a dangerous leakage current.

Preliminary Evaluation of Alternate Designs for HFIR Low-Enriched Uranium Fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renfro, David G; Chandler, David; Cook, David Howard

2014-11-01

Engineering design studies of the feasibility of conversion of the High Flux Isotope Reactor (HFIR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel are ongoing at Oak Ridge National Laboratory (ORNL) as part of an effort sponsored by the U.S. Department of Energy s Global Threat Reduction Initiative (GTRI)/Reduced Enrichment for Research and Test Reactors (RERTR) program. The fuel type selected by the program for the conversion of the five high-power research reactors in the U.S. that still use HEU fuel is a new U-Mo monolithic fuel. Studies by ORNL have previously indicated that HFIR can be successfully convertedmore » using the new fuel provided (1) the reactor power can be increased from 85 MW to 100 MW and (2) the fuel can be fabricated to a specific reference design. Fabrication techniques for the new fuel are under development by the program but are still immature, especially for the complex aspects of the HFIR fuel design. In FY 2012, the program underwent a major shift in focus to emphasize developing and qualifying processes for the fabrication of reliable and affordable LEU fuel. In support of this new focus and in an effort to ensure that the HFIR fuel design is as suitable for reliable fabrication as possible, ORNL undertook the present study to propose and evaluate several alternative design features. These features include (1) eliminating the fuel zone axial contouring in the previous reference design by substituting a permanent neutron absorber in the lower unfueled region of all of the fuel plates, (2) relocating the burnable neutron absorber from the fuel plates of the inner fuel element to the side plates of the inner fuel element (the fuel plates of the outer fuel element do not contain a burnable absorber), (3) relocating the fuel zone inside the fuel plate to be centered on the centerline of the depth of the plate, and (4) reshaping the radial contour of the relocated fuel zone to be symmetric about this centerline. The present studies used current analytical tools to evaluate the various alternate designs for cycle length, scientific performance (e.g., neutron scattering), and steady-state and transient thermal performance using both safety limit and nominal parameter assumptions. The studies concluded that a new reference design combining a permanent absorber in the lower unfueled region of all of the fuel plates, a burnable absorber in the inner element side plates, and a relocated and reshaped (but still radially contoured) fuel zone will allow successful conversion of HFIR. Future collaboration with the program will reveal whether the new reference design can be fabricated reliably and affordably. Following this feedback, additional studies using state-of-the-art developmental analytical tools are proposed to optimize the design of the fuel zone radial contour and the amount and location of both types of neutron absorbers to further flatten thermal peaks while maximizing the performance of the reactor.« less

GEOdetic Data assimilation and EStimation of references for climate change InvEstigation. An overall presentation of the French GEODESIE project

NASA Astrophysics Data System (ADS)

Coulot, David; Richard, Jean-Yves

2017-04-01

Many major indicators of climate change are monitored with space observations (sea level rise from satellite altimetry, ice melting from dedicated satellites, etc.). This monitoring is highly dependent on references (positions and velocities of ground observing instruments, orbits of satellites, etc.) that only geodesy can provide. The current accuracy of these references does not permit to fully support the challenges that the constantly evolving Earth system gives rise to, and can consequently limit the accuracy of these indicators. For this reason, in the framework of the Global Geodetic Observing System (GGOS), stringent requirements are fixed to the International Terrestrial Reference Frame (ITRF) for the next decade: an accuracy at the level of 1 mm and a stability at the level of 0.1 mm/yr. This means an improvement of the current quality of ITRF by a factor of 5-10. Improving the quality of the geodetic references is an issue which requires a thorough reassessment of the methodologies involved. The most relevant and promising method to improve this quality is the direct combination (Combination at Observation Level - COL) of the space-geodetic measurements used to compute the official references of the International Earth Rotation and Reference Systems Service (IERS). The GEODESIE project aims at (i) determining highly-accurate global and consistent references (time series of Terrestrial Reference Frames and Celestial Reference Frames, of Earth's Orientation Parameters, and orbits of Earth's observation satellites) and (ii) providing the geophysical and climate research communities with these references, for a better estimation of geocentric sea level rise, ice mass balance and on-going climate changes. Time series of sea levels computed from altimetric data and tide gauge records with these references (orbits of satellite altimeters, Terrestrial Reference Frames and related vertical velocities of stations) will also be provided. The geodetic references will be essential bases for Earth's observation and monitoring to support the challenges of the century. The geocentric time series of sea levels will permit to better apprehend (i) the drivers of the global mean sea level rise and of regional variations of sea level and (ii) the contribution of the global climate change induced by anthropogenic greenhouse gases emissions to these drivers. All the results and computation and quality assessment reports will be available on a Website designed and opened in the Summer of 2017. This project, supported by the French Agence Nationale de la Recherche (ANR) for the period 2017-2020, will be an unprecedented opportunity to provide the French Groupe de Recherche de Géodésie Spatiale (GRGS) with complete simulation and data processing capabilities to prepare the future arrival of space missions such as the European Geodetic Reference Antenna in SPace (E-GRASP) and to significantly contribute to the GGOS with accurate references.

Automotive Stirling engine development program - Overview and status report

NASA Technical Reports Server (NTRS)

Nightingale, N. P.

1983-01-01

The current status of the automotive-Stirling-engine development program being undertaken by DOE and NASA Lewis is reviewed. The program goals and the reference-engine design are explained, and the modifications introduced to improve performance and lower manufacturing costs are discussed and illustrated, including part-power optimization; increased operating temperature (from 720 to 820 C); 45.4-kg weight reduction; elimination of Co and reduction of Cr used; and improved seals, ceramic components, and high-temperature alloys. The test program, some difficulties encountered, and results after 2042 h are summarized.

Crew appliance study

NASA Technical Reports Server (NTRS)

Proctor, B. W.; Reysa, R. P.; Russell, D. J.

1975-01-01

Viable crew appliance concepts were identified by means of a thorough literature search. Studies were made of the food management, personal hygiene, housekeeping, and off-duty habitability functions to determine which concepts best satisfy the Space Shuttle Orbiter and Modular Space Station mission requirements. Models of selected appliance concepts not currently included in the generalized environmental-thermal control and life support systems computer program were developed and validated. Development plans of selected concepts were generated for future reference. A shuttle freezer conceptual design was developed and a test support activity was provided for regenerative environmental control life support subsystems.

USGS tethered ACP platforms: New design means more safety and accuracy

USGS Publications Warehouse

Morlock, S.E.; Stewart, J.A.; Rehmel, M.S.

2004-01-01

The US Geological Survey has developed an innovative tethered platform that supports an Acoustic Current Profiler (ACP) in making stream-flow measurements (use of the term ACP in this article refers to a class of instruments and not a specific brand name or model). The tethered platform reduces the hazards involved in conventional methods of stream-flow measurement. The use of the platform reduces or eliminates time spent by personnel in streams and boats or on bridges and cableway and stream-flow measurement accuracy is increased.

Sonic Boom Minimization Efforts on Boeing HSCT Baseline

NASA Technical Reports Server (NTRS)

Cheung, Samson H.; Fouladi, Kamran; Haglund, George; Tu, Eugene

1999-01-01

A team was formed to tackle the sonic boom softening issues of the current Boeing HSCT design. The team consisted of personnel from NASA Ames, NASA Langley, and Boeing company. The work described in this paper was done when the first author was at NASA Ames Research Center. This paper presents the sonic boom softening work on two Boeing High Speed Civil Transport (HSCT) baseline configurations, Reference-H and Boeing-1122. This presentation can be divided into two parts: parametric studies and sonic boom minimization by CFD optimization routines.

Initial characterization of an Experimental Referee Broadened-Specification (ERBS) aviation turbine fuel

NASA Technical Reports Server (NTRS)

Prok, G. M.; Seng, G. T.

1980-01-01

Characterization data and a hydrocarbon compositional analysis are presented for a research test fuel designated as an experimental referee broadened-specification aviation turbine fuel. This research fuel, which is a special blend of kerosene and hydrotreated catalytic gas oil, is a hypothetical representation of a future fuel should it become necessary to broaden current kerojet specifications. It is used as a reference fuel in research investigations into the effects of fuel property variations on the performance and durability of jet aircraft components, including combustors and fuel systems.

The organization of successful participative management in a health sciences library.

PubMed Central

Wood, M B

1977-01-01

The University of Washington Health Sciences Library, Seattle, and its participative management process are described in detail. The evolution of the management system is reviewed by interrelating the various phases of the library's growth, its service complexities, and its communication needs. Staff development results of this participative management mode are discussed. Reference is made to the use of group dynamics concepts. The current organizational design, which integrates the participative subunit with the simple line management structure, is considered effective by both the library staff and its director. PMID:843648

Criticality safety evaluation for the Advanced Test Reactor enhanced low enriched uranium fuel elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montierth, Leland M.

2016-07-19

The Global Threat Reduction Initiative (GTRI) convert program is developing a high uranium density fuel based on a low enriched uranium (LEU) uranium-molybdenum alloy. Testing of prototypic GTRI fuel elements is necessary to demonstrate integrated fuel performance behavior and scale-up of fabrication techniques. GTRI Enhanced LEU Fuel (ELF) elements based on the ATR-Standard Size elements (all plates fueled) are to be fabricated for testing in the Advanced Test Reactor (ATR). While a specific ELF element design will eventually be provided for detailed analyses and in-core testing, this criticality safety evaluation (CSE) is intended to evaluate a hypothetical ELF element designmore » for criticality safety purposes. Existing criticality analyses have analyzed Standard (HEU) ATR elements from which controls have been derived. This CSE documents analysis that determines the reactivity of the hypothetical ELF fuel elements relative to HEU ATR elements and whether the existing HEU ATR element controls bound the ELF element. The initial calculations presented in this CSE analyzed the original ELF design, now referred to as Mod 0.1. In addition, as part of a fuel meat thickness optimization effort for reactor performance, other designs have been evaluated. As of early 2014 the most current conceptual designs are Mk1A and Mk1B, that were previously referred to as conceptual designs Mod 0.10 and Mod 0.11, respectively. Revision 1 evaluates the reactivity of the ATR HEU Mark IV elements for a comparison with the Mark VII elements.« less

M3BA: A Mobile, Modular, Multimodal Biosignal Acquisition Architecture for Miniaturized EEG-NIRS-Based Hybrid BCI and Monitoring.

PubMed

von Luhmann, Alexander; Wabnitz, Heidrun; Sander, Tilmann; Muller, Klaus-Robert

2017-06-01

For the further development of the fields of telemedicine, neurotechnology, and brain-computer interfaces, advances in hybrid multimodal signal acquisition and processing technology are invaluable. Currently, there are no commonly available hybrid devices combining bioelectrical and biooptical neurophysiological measurements [here electroencephalography (EEG) and functional near-infrared spectroscopy (NIRS)]. Our objective was to design such an instrument in a miniaturized, customizable, and wireless form. We present here the design and evaluation of a mobile, modular, multimodal biosignal acquisition architecture (M3BA) based on a high-performance analog front-end optimized for biopotential acquisition, a microcontroller, and our openNIRS technology. The designed M3BA modules are very small configurable high-precision and low-noise modules (EEG input referred noise @ 500 SPS 1.39 μV pp , NIRS noise equivalent power NEP 750 nm = 5.92 pW pp , and NEP 850 nm = 4.77 pW pp ) with full input linearity, Bluetooth, 3-D accelerometer, and low power consumption. They support flexible user-specified biopotential reference setups and wireless body area/sensor network scenarios. Performance characterization and in-vivo experiments confirmed functionality and quality of the designed architecture. Telemedicine and assistive neurotechnology scenarios will increasingly include wearable multimodal sensors in the future. The M3BA architecture can significantly facilitate future designs for research in these and other fields that rely on customized mobile hybrid biosignal modal biosignal acquisition architecture (M3BA), multimodal, near-infrared spectroscopy (NIRS), wireless body area network (WBAN), wireless body sensor network (WBSN).

Design and operation of a Loran-C time reference station

NASA Technical Reports Server (NTRS)

Putkovich, K.

1974-01-01

Some of the practical questions that arise when one decides to use Loran-C in a time reference system are explored. An extensive effort is made to provide basic, practical information on establishing and operating a reference station. Four areas were covered: (1) the design, configuration and operational concepts which should be considered prior to establishing and operating a reference station using Loran-C, (2) the options and tradeoffs available regarding capabilities, cost, size, versatility, ease of operation, etc., that are available to the designer, (3) what measurements are made, how they are made and what they mean, and (4) the experience the U.S. Naval Observatory Time Service Division has had in the design and operation of such stations.

An extended protocol for usability validation of medical devices: Research design and reference model.

PubMed

Schmettow, Martin; Schnittker, Raphaela; Schraagen, Jan Maarten

2017-05-01

This paper proposes and demonstrates an extended protocol for usability validation testing of medical devices. A review of currently used methods for the usability evaluation of medical devices revealed two main shortcomings. Firstly, the lack of methods to closely trace the interaction sequences and derive performance measures. Secondly, a prevailing focus on cross-sectional validation studies, ignoring the issues of learnability and training. The U.S. Federal Drug and Food Administration's recent proposal for a validation testing protocol for medical devices is then extended to address these shortcomings: (1) a novel process measure 'normative path deviations' is introduced that is useful for both quantitative and qualitative usability studies and (2) a longitudinal, completely within-subject study design is presented that assesses learnability, training effects and allows analysis of diversity of users. A reference regression model is introduced to analyze data from this and similar studies, drawing upon generalized linear mixed-effects models and a Bayesian estimation approach. The extended protocol is implemented and demonstrated in a study comparing a novel syringe infusion pump prototype to an existing design with a sample of 25 healthcare professionals. Strong performance differences between designs were observed with a variety of usability measures, as well as varying training-on-the-job effects. We discuss our findings with regard to validation testing guidelines, reflect on the extensions and discuss the perspectives they add to the validation process. Copyright © 2017 Elsevier Inc. All rights reserved.

The Then and Now of Reference Conditions in Streams of the Central Plains

NASA Astrophysics Data System (ADS)

Huggins, D.; Angelo, R.; Baker, D. S.; Welker, G.

2005-05-01

Models of contemporary and pre-settlement reference conditions were constructed for streams that once drained the tallgrass prairies of Iowa, Nebraska, Kansas and Missouri (e.g. Western Corn Belt Plains ecoregion), and for streams within the heart of the mixed grass prairie (e.g. Southwestern Tablelands ecoregion). Data on watershed, habitat, chemistry and biology compiled for existing reference streams (least or minimally impacted systems) were used to characterize contemporary reference conditions. Contemporary reference conditions within these two prairie regions are contrasted against hypothetical pre-settlement conditions using information from the best streams (upper 25%) of the current reference population, historical accounts, museum records, natural heritage programs, Public Land Survey and current remote sensing data. Similar comparisons were made between historical and current reference conditions for the Southwestern Tablelands located in central Kansas and Oklahoma. Much of this region remains in mixed grass prairie; has limited hydrological alterations (e.g. impoundments, dewatering) and low human and livestock densities. Within the tablelands these factors have preserved reference conditions that resemble historic conditions. Qualitative and quantitative comparisons indicate that many regions within the Central Plains require caution when using "least disturbed" reference streams and conditions to identify regional biological integrity goals relative to the Clean Water Act.

[Theoretical and methodological uses of research in Social and Human Sciences in Health].

PubMed

Deslandes, Suely Ferreira; Iriart, Jorge Alberto Bernstein

2012-12-01

The current article aims to map and critically reflect on the current theoretical and methodological uses of research in the subfield of social and human sciences in health. A convenience sample was used to select three Brazilian public health journals. Based on a reading of 1,128 abstracts published from 2009 to 2010, 266 articles were selected that presented the empirical base of research stemming from social and human sciences in health. The sample was classified thematically as "theoretical/ methodological reference", "study type/ methodological design", "analytical categories", "data production techniques", and "analytical procedures". We analyze the sample's emic categories, drawing on the authors' literal statements. All the classifications and respective variables were tabulated in Excel. Most of the articles were self-described as qualitative and used more than one data production technique. There was a wide variety of theoretical references, in contrast with the almost total predominance of a single type of data analysis (content analysis). In several cases, important gaps were identified in expounding the study methodology and instrumental use of the qualitative research techniques and methods. However, the review did highlight some new objects of study and innovations in theoretical and methodological approaches.

Ultrastable low-noise current amplifier: a novel device for measuring small electric currents with high accuracy.

PubMed

Drung, D; Krause, C; Becker, U; Scherer, H; Ahlers, F J

2015-02-01

An ultrastable low-noise current amplifier (ULCA) is presented. The ULCA is a non-cryogenic instrument based on specially designed operational amplifiers and resistor networks. It involves two stages, the first providing a 1000-fold current gain and the second performing a current-to-voltage conversion via an internal 1 MΩ reference resistor or, optionally, an external standard resistor. The ULCA's transfer coefficient is highly stable versus time, temperature, and current amplitude within the full dynamic range of ±5 nA. The low noise level of 2.4 fA/√Hz helps to keep averaging times short at small input currents. A cryogenic current comparator is used to calibrate both input current gain and output transresistance, providing traceability to the quantum Hall effect. Within one week after calibration, the uncertainty contribution from short-term fluctuations and drift of the transresistance is about 0.1 parts per million (ppm). The long-term drift is typically 5 ppm/yr. A high-accuracy variant is available that shows improved stability of the input gain at the expense of a higher noise level of 7.5 fA/√Hz. The ULCA also allows the traceable generation of small electric currents or the calibration of high-ohmic resistors.

Ultrastable low-noise current amplifier: A novel device for measuring small electric currents with high accuracy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drung, D.; Krause, C.; Becker, U.

2015-02-15

An ultrastable low-noise current amplifier (ULCA) is presented. The ULCA is a non-cryogenic instrument based on specially designed operational amplifiers and resistor networks. It involves two stages, the first providing a 1000-fold current gain and the second performing a current-to-voltage conversion via an internal 1 MΩ reference resistor or, optionally, an external standard resistor. The ULCA’s transfer coefficient is highly stable versus time, temperature, and current amplitude within the full dynamic range of ±5 nA. The low noise level of 2.4 fA/√Hz helps to keep averaging times short at small input currents. A cryogenic current comparator is used to calibratemore » both input current gain and output transresistance, providing traceability to the quantum Hall effect. Within one week after calibration, the uncertainty contribution from short-term fluctuations and drift of the transresistance is about 0.1 parts per million (ppm). The long-term drift is typically 5 ppm/yr. A high-accuracy variant is available that shows improved stability of the input gain at the expense of a higher noise level of 7.5 fA/√Hz. The ULCA also allows the traceable generation of small electric currents or the calibration of high-ohmic resistors.« less

Ultrastable low-noise current amplifier: A novel device for measuring small electric currents with high accuracy

NASA Astrophysics Data System (ADS)

Drung, D.; Krause, C.; Becker, U.; Scherer, H.; Ahlers, F. J.

2015-02-01

An ultrastable low-noise current amplifier (ULCA) is presented. The ULCA is a non-cryogenic instrument based on specially designed operational amplifiers and resistor networks. It involves two stages, the first providing a 1000-fold current gain and the second performing a current-to-voltage conversion via an internal 1 MΩ reference resistor or, optionally, an external standard resistor. The ULCA's transfer coefficient is highly stable versus time, temperature, and current amplitude within the full dynamic range of ±5 nA. The low noise level of 2.4 fA/√Hz helps to keep averaging times short at small input currents. A cryogenic current comparator is used to calibrate both input current gain and output transresistance, providing traceability to the quantum Hall effect. Within one week after calibration, the uncertainty contribution from short-term fluctuations and drift of the transresistance is about 0.1 parts per million (ppm). The long-term drift is typically 5 ppm/yr. A high-accuracy variant is available that shows improved stability of the input gain at the expense of a higher noise level of 7.5 fA/√Hz. The ULCA also allows the traceable generation of small electric currents or the calibration of high-ohmic resistors.

On the safety of ITER accelerators.

PubMed

Li, Ge

2013-01-01

Three 1 MV/40A accelerators in heating neutral beams (HNB) are on track to be implemented in the International Thermonuclear Experimental Reactor (ITER). ITER may produce 500 MWt of power by 2026 and may serve as a green energy roadmap for the world. They will generate -1 MV 1 h long-pulse ion beams to be neutralised for plasma heating. Due to frequently occurring vacuum sparking in the accelerators, the snubbers are used to limit the fault arc current to improve ITER safety. However, recent analyses of its reference design have raised concerns. General nonlinear transformer theory is developed for the snubber to unify the former snubbers' different design models with a clear mechanism. Satisfactory agreement between theory and tests indicates that scaling up to a 1 MV voltage may be possible. These results confirm the nonlinear process behind transformer theory and map out a reliable snubber design for a safer ITER.

Light Water Reactor Sustainability Program: Risk-Informed Safety Margins Characterization (RISMC) Pathway Technical Program Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis; Rabiti, Cristian; Martineau, Richard

Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). As the current Light Water Reactor (LWR) NPPs age beyond 60 years, there are possibilities for increased frequency of Systems, Structures, and Components (SSCs) degradations or failures that initiate safety-significant events, reduce existing accident mitigation capabilities, or create new failure modes. Plant designers commonly “over-design” portions of NPPs and provide robustness in the form of redundant and diverse engineered safety features to ensure that, even in the case of well-beyond design basis scenarios, public health and safety will be protected with a very high degreemore » of assurance. This form of defense-in-depth is a reasoned response to uncertainties and is often referred to generically as “safety margin.” Historically, specific safety margin provisions have been formulated, primarily based on “engineering judgment.”« less

On the safety of ITER accelerators

PubMed Central

Li, Ge

2013-01-01

Three 1 MV/40A accelerators in heating neutral beams (HNB) are on track to be implemented in the International Thermonuclear Experimental Reactor (ITER). ITER may produce 500 MWt of power by 2026 and may serve as a green energy roadmap for the world. They will generate −1 MV 1 h long-pulse ion beams to be neutralised for plasma heating. Due to frequently occurring vacuum sparking in the accelerators, the snubbers are used to limit the fault arc current to improve ITER safety. However, recent analyses of its reference design have raised concerns. General nonlinear transformer theory is developed for the snubber to unify the former snubbers' different design models with a clear mechanism. Satisfactory agreement between theory and tests indicates that scaling up to a 1 MV voltage may be possible. These results confirm the nonlinear process behind transformer theory and map out a reliable snubber design for a safer ITER. PMID:24008267

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Chouhan, J. DeKamp, A. Zeller, P. Brindza, S. Lassiter, M. Fowler, E. Sun

A collaboration between NSCL and Jlab has developed the reference design and coil winding for Jlab's Super High Momentum Spectrometer (SHMS) horizontal bend magnet. A warm iron ??C?? type superferric dipole magnet will bend the 12 GeV/c particles horizontally by 3?? to allow the SHMS to reach angles as low as 5.5??. This requires an integral field strength of up to 2.1 T.m. The major challenges are the tight geometry, high and unbalanced forces and a required low fringe field in primary beam path. A coil design based on flattened SSC Rutherford cable that provides a large current margin andmore » commercially available fiberglass prepreg epoxy tape has been developed. A complete test coil has been wound and will be cold tested. This paper present the modified magnet design includes coil forces, coil restraint system and fringe field. In addition, coil properties, quench calculations and the full mechanical details are also presented.« less

Improvement of the System of Training of Specialists by University for Coal Mining Enterprises

NASA Astrophysics Data System (ADS)

Mikhalchenko, Vadim; Seredkina, Irina

2017-11-01

In the article the ingenious technique of the Quality Function Deployment with reference to the process of training of specialists with higher education by university is considered. The method is based on the step-by-step conversion of customer requirements into specific organizational, meaningful and functional transformations of the technological process of the university. A fully deployed quality function includes four stages of tracking customer requirements while creating a product: product planning and design, process design, production design. The Quality Function Deployment can be considered as one of the methods for optimizing the technological processes of training of specialists with higher education in the current economic conditions. Implemented at the initial stages of the life cycle of the technological process, it ensures not only the high quality of the "product" of graduate school, but also the fullest possible satisfaction of consumer's requests and expectations.

CodeSlinger: a case study in domain-driven interactive tool design for biomedical coding scheme exploration and use.

PubMed

Flowers, Natalie L

2010-01-01

CodeSlinger is a desktop application that was developed to aid medical professionals in the intertranslation, exploration, and use of biomedical coding schemes. The application was designed to provide a highly intuitive, easy-to-use interface that simplifies a complex business problem: a set of time-consuming, laborious tasks that were regularly performed by a group of medical professionals involving manually searching coding books, searching the Internet, and checking documentation references. A workplace observation session with a target user revealed the details of the current process and a clear understanding of the business goals of the target user group. These goals drove the design of the application's interface, which centers on searches for medical conditions and displays the codes found in the application's database that represent those conditions. The interface also allows the exploration of complex conceptual relationships across multiple coding schemes.

Fiber-Optic Sensor for Aircraft Lightning Current Measurement

NASA Technical Reports Server (NTRS)

Nguyen, Truong X.; Ely, Jay J.; Szatkowski, George G.; Mata, Carlos T.; Mata,Angel G.; Snyder, Gary P.

2012-01-01

An electric current sensor based on Faraday rotation effect in optical fiber was developed for measuring aircraft lightning current. Compared to traditional sensors, the design has many advantages including the ability to measure total current and to conform to structure geometries. The sensor is also small, light weight, non-conducting, safe from interference, and free of hysteresis and saturation. Potential applications include characterization of lightning current waveforms, parameters and paths, and providing environmental data for aircraft certifications. In an optical fiber as the sensing medium, light polarization rotates when exposed to a magnetic field in the direction of light propagation. By forming closed fiber loops around a conductor and applying Ampere s law, measuring the total light rotation yields the enclosed current. A reflective polarimetric scheme is used, where polarization change is measured after the polarized light travels round-trip through the sensing fiber. The sensor system was evaluated measuring rocket-triggered lightning over the 2011 summer. Early results compared very well against a reference current shunt resistor, demonstrating the sensor's accuracy and feasibility in a lightning environment. While later comparisons show gradually increasing amplitude deviations for an undetermined cause, the overall waveforms still compared very well.

Fiber-Optic Sensor for Aircraft Lightning Current Measurement

NASA Technical Reports Server (NTRS)

Nguyen, Truong X.; Ely, Jay J.; Szatkowski, George G.; Mata, Carlos T.; Mata, Angel G.; Snyder, Gary P.

2012-01-01

An electric current sensor based on Faraday rotation effect in optical fiber was developed for measuring aircraft lightning current. Compared to traditional sensors, the design has many advantages including the ability to measure total current and to conform to structure geometries. The sensor is also small, light weight, non-conducting, safe from interference, and free of hysteresis and saturation. Potential applications include characterization of lightning current waveforms, parameters and paths, and providing environmental data for aircraft certifications. In an optical fiber as the sensing medium, light polarization rotates when exposed to a magnetic field in the direction of light propagation. By forming closed fiber loops around a conductor and applying Ampere s law, measuring the total light rotation yields the enclosed current. A reflective polarimetric scheme is used, where polarization change is measured after the polarized light travels round-trip through the sensing fiber. The sensor system was evaluated measuring rocket-triggered lightning over the 2011 summer. Early results compared very well against a reference current shunt resistor, demonstrating the sensor s accuracy and feasibility in a lightning environment. While later comparisons show gradually increasing amplitude deviations for an undetermined cause, the overall waveforms still compared very well.

Use and Perceived Benefits of Handheld Computer-based Clinical References

PubMed Central

Rothschild, Jeffrey M.; Fang, Edward; Liu, Vincent; Litvak, Irina; Yoon, Cathy; Bates, David W.

2006-01-01

Objective Clinicians are increasingly using handheld computers (HC) during patient care. We sought to assess the role of HC-based clinical reference software in medical practice by conducting a survey and assessing actual usage behavior. Design During a 2-week period in February 2005, 3600 users of a HC-based clinical reference application were asked by e-mail to complete a survey and permit analysis of their usage patterns. The software includes a pharmacopeia, an infectious disease reference, a medical diagnostic and therapeutic reference and transmits medical alerts and other notifications during HC synchronizations. Software usage data were captured during HC synchronization for the 4 weeks prior to survey completion. Measurements Survey responses and software usage data. Results The survey response rate was 42% (n = 1501). Physicians reported using the clinical reference software for a mean of 4 years and 39% reported using the software during more than half of patient encounters. Physicians who synchronized their HC during the data collection period (n = 1249; 83%) used the pharmacopeia for unique drug lookups a mean of 6.3 times per day (SD 12.4). The majority of users (61%) believed that in the prior 4 weeks, use of the clinical reference prevented adverse drug events or medication errors 3 or more times. Physicians also believed that alerts and other notifications improved patient care if they were public health warnings (e.g. about influenza), new immunization guidelines or drug alert warnings (e.g. rofecoxib withdrawal). Conclusion Current adopters of HC-based medical references use these tools frequently, and found them to improve patient care and be valuable in learning of recent alerts and warnings. PMID:16929041

Psychological distress among Plains Indian mothers with children referred to screening for Fetal Alcohol Spectrum Disorders

PubMed Central

2010-01-01

Background Psychological distress (PD) includes symptoms of depression and anxiety and is associated with considerable emotional suffering, social dysfunction and, often, with problematic alcohol use. The rate of current PD among American Indian women is approximately 2.5 times higher than that of U.S. women in general. Our study aims to fill the current knowledge gap about the prevalence and characteristics of PD and its association with self-reported current drinking problems among American Indian mothers whose children were referred to screening for fetal alcohol spectrum disorders (FASD). Methods Secondary analysis of cross-sectional data was conducted from maternal interviews of referred American Indian mothers (n = 152) and a comparison group of mothers (n = 33) from the same Plains culture tribes who participated in an NIAAA-funded epidemiology study of FASD. Referred women were from one of six Plains Indian reservation communities and one urban area who bore children suspected of having an FASD. A 6-item PD scale (PD-6, Cronbach's alpha = .86) was constructed with a summed score range of 0-12 and a cut-point of 7 indicating serious PD. Multiple statistical tests were used to examine the characteristics of PD and its association with self-reported current drinking problems. Results Referred and comparison mothers had an average age of 31.3 years but differed (respectively) on: education (

Design and validation of an open-source library of dynamic reference frames for research and education in optical tracking.

PubMed

Brown, Alisa; Uneri, Ali; Silva, Tharindu De; Manbachi, Amir; Siewerdsen, Jeffrey H

2018-04-01

Dynamic reference frames (DRFs) are a common component of modern surgical tracking systems; however, the limited number of commercially available DRFs poses a constraint in developing systems, especially for research and education. This work presents the design and validation of a large, open-source library of DRFs compatible with passive, single-face tracking systems, such as Polaris stereoscopic infrared trackers (NDI, Waterloo, Ontario). An algorithm was developed to create new DRF designs consistent with intra- and intertool design constraints and convert to computer-aided design (CAD) files suitable for three-dimensional printing. A library of 10 such groups, each with 6 to 10 DRFs, was produced and tracking performance was validated in comparison to a standard commercially available reference, including pivot calibration, fiducial registration error (FRE), and target registration error (TRE). Pivot tests showed calibration error [Formula: see text], indistinguishable from the reference. FRE was [Formula: see text], and TRE in a CT head phantom was [Formula: see text], both equivalent to the reference. The library of DRFs offers a useful resource for surgical navigation research and could be extended to other tracking systems and alternative design constraints.

Two-electrode non-differential biopotential amplifier.

PubMed

Dobrev, D

2002-09-01

A circuit is proposed for a non-differential two-electrode biopotential amplifier, with a current source and a transimpedance amplifier as a potential equaliser for its inputs, fully emulating a differential amplifier. The principle of operation is that the current in the input of the transimpedance amplifier is sensed and made to flow with the same value in the other input. The circuit has a simple structure and uses a small number of components. The current source maintains balanced common-mode interference currents, thus ensuring high signal input impedance. In addition, these currents can be tolerated up to more than 10 microA per input, at a supply voltage of +/- 5 V. A two-electrode differential amplifier with 2 x 10 Mohm input resistances to the reference point allows less than 0.5 microA per input. The circuit can be useful in cases of biosignal acquisition by portable instruments, using low supply voltages, from subjects in areas of high electromagnetic fields. Examples include biosignal recordings in electric power stations and electrically powered locomotives, where traditionally designed input amplifier stages can be saturated.

Nondestructive examination of the Tropical Rainfall Measuring Mission (TRMM) reaction control subsystem (RCS) propellant tanks

NASA Technical Reports Server (NTRS)

Free, James M.

1993-01-01

This paper assesses the feasibility of using eddy current nondestructive examination to determine flaw sizes in completely assembled hydrazine propellant tanks. The study was performed by the NASA Goddard Space Flight Center for the Tropical Rainfall Measuring Mission (TRMM) project to help determine whether existing propellant tanks could meet the fracture analysis requirements of the current pressure vessel specification, MIL-STD-1522A and, therefore be used on the TRMM spacecraft. After evaluating several nondestructive test methods, eddy current testing was selected as the most promising method for determining flaw sizes on external and internal surfaces of completely assembled tanks. Tests were conducted to confirm the detection capability of the eddy current NDE, procedures were developed to inspect two candidate tanks, and the test support equipment was designed. The non-spherical tank eddy current NDE test program was terminated when the decision was made to procure new tanks for the TRMM propulsion subsystem. The information on the development phase of this test program is presented in this paper as a reference for future investigation on the subject.

Design of a hydrophone for an Ocean World lander

NASA Astrophysics Data System (ADS)

Smith, Heather D.; Duncan, Andrew G.

2017-10-01

For this presentation we describe the science return, and design of a microphone on- board a Europa lander mission. In addition to the E/PO benefit of a hydrophone to listen to the Europa Ocean, a microphone also provides scientific data on the properties of the subsurface ocean.A hydrophone is a small light-weight instrument that could be used to achieve two of the three Europa Lander mission anticipated science goals of: 1) Asses the habitability (particularly through quantitative compositional measurements of Europa via in situ techniques uniquely available to a landed mission. And 2) Characterize surface properties at the scale of the lander to support future exploration, including the local geologic context.Acoustic properties of the ocean would lead to a better understanding of the water density, currents, seafloor topography and other physical properties of the ocean as well as lead to an understanding of the salinity of the ocean. Sound from water movement (tidal movement, currents, subsurface out-gassing, ocean homogeneity (clines), sub-surface morphology, and biological sounds.The engineering design of the hydrophone instrument will be designed to fit within a portion of the resource allocation of the current best estimates of the Europa lander payload (26.6 Kg, 24,900 cm3, 2,500 W-hrs and 2700 Mbits). The hydrophone package will be designed to ensure planetary protection is maintained and will function under the cur- rent Europa lander mission operations scenario of a two-year cruise phase, and 30-day surface operational phase on Europa.Although the microphone could be used on the surface, it is designed to be lowered into the subsurface ocean. As such, planetary protection (forward contamination) is a primary challenge for a subsurface microphone/ camera. The preliminary design is based on the Navy COTS optical microphone.Reference: Pappalardo, R. T., et al. "Science potential from a Europa lander." Astrobiology 13.8 (2013): 740-773.

The AOLI Non-Linear Curvature Wavefront Sensor: High sensitivity reconstruction for low-order AO

NASA Astrophysics Data System (ADS)

Crass, Jonathan; King, David; Mackay, Craig

2013-12-01

Many adaptive optics (AO) systems in use today require bright reference objects to determine the effects of atmospheric distortions on incoming wavefronts. This requirement is because Shack Hartmann wavefront sensors (SHWFS) distribute incoming light from reference objects into a large number of sub-apertures. Bright natural reference objects occur infrequently across the sky leading to the use of laser guide stars which add complexity to wavefront measurement systems. The non-linear curvature wavefront sensor as described by Guyon et al. has been shown to offer a significant increase in sensitivity when compared to a SHWFS. This facilitates much greater sky coverage using natural guide stars alone. This paper describes the current status of the non-linear curvature wavefront sensor being developed as part of an adaptive optics system for the Adaptive Optics Lucky Imager (AOLI) project. The sensor comprises two photon-counting EMCCD detectors from E2V Technologies, recording intensity at four near-pupil planes. These images are used with a reconstruction algorithm to determine the phase correction to be applied by an ALPAO 241-element deformable mirror. The overall system is intended to provide low-order correction for a Lucky Imaging based multi CCD imaging camera. We present the current optical design of the instrument including methods to minimise inherent optical effects, principally chromaticity. Wavefront reconstruction methods are discussed and strategies for their optimisation to run at the required real-time speeds are introduced. Finally, we discuss laboratory work with a demonstrator setup of the system.

Food Web Bioaccumulation Model for Resident Killer Whales from the Northeastern Pacific Ocean as a Tool for the Derivation of PBDE-Sediment Quality Guidelines.

PubMed

Alava, Juan José; Ross, Peter S; Gobas, Frank A P C

2016-01-01

Resident killer whale populations in the NE Pacific Ocean are at risk due to the accumulation of pollutants, including polybrominated diphenyl ethers (PBDEs). To assess the impact of PBDEs in water and sediments in killer whale critical habitat, we developed a food web bioaccumulation model. The model was designed to estimate PBDE concentrations in killer whales based on PBDE concentrations in sediments and the water column throughout a lifetime of exposure. Calculated and observed PBDE concentrations exceeded the only toxicity reference value available for PBDEs in marine mammals (1500 μg/kg lipid) in southern resident killer whales but not in northern resident killer whales. Temporal trends (1993-2006) for PBDEs observed in southern resident killer whales showed a doubling time of ≈5 years. If current sediment quality guidelines available in Canada for polychlorinated biphenyls are applied to PBDEs, it can be expected that PBDE concentrations in killer whales will exceed available toxicity reference values by a large margin. Model calculations suggest that a PBDE concentration in sediments of approximately 1.0 μg/kg dw produces PBDE concentrations in resident killer whales that are below the current toxicity reference value for 95 % of the population, with this value serving as a precautionary benchmark for a management-based approach to reducing PBDE health risks to killer whales. The food web bioaccumulation model may be a useful risk management tool in support of regulatory protection for killer whales.

LIFE: a sustainable solution for developing safe, clean fusion power.

PubMed

Reyes, Susana; Dunne, Mike; Kramer, Kevin; Anklam, Tom; Havstad, Mark; Mazuecos, Antonio Lafuente; Miles, Robin; Martinez-Frias, Joel; Deri, Bob

2013-06-01

The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) in California is currently in operation with the goal to demonstrate fusion energy gain for the first time in the laboratory-also referred to as "ignition." Based on these demonstration experiments, the Laser Inertial Fusion Energy (LIFE) power plant is being designed at LLNL in partnership with other institutions with the goal to deliver baseload electricity from safe, secure, sustainable fusion power in a time scale that is consistent with the energy market needs. For this purpose, the LIFE design takes advantage of recent advances in diode-pumped, solid-state laser technology and adopts the paradigm of Line Replaceable Units used on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. The LIFE market entry plant will demonstrate the feasibility of a closed fusion fuel cycle, including tritium breeding, extraction, processing, refueling, accountability, and safety, in a steady-state power-producing device. While many fusion plant designs require large quantities of tritium for startup and operations, a range of design choices made for the LIFE fuel cycle act to reduce the in-process tritium inventory. This paper presents an overview of the delivery plan and the preconceptual design of the LIFE facility with emphasis on the key safety design principles being adopted. In order to illustrate the favorable safety characteristics of the LIFE design, some initial accident analysis results are presented that indicate potential for a more attractive licensing regime than that of current fission reactors.

MSDS sky reference and preamplifier study

NASA Technical Reports Server (NTRS)

Larsen, L.; Stewart, S.; Lambeck, P.

1974-01-01

The major goals in re-designing the Multispectral Scanner and Data System (MSDS) sky reference are: (1) to remove the sun-elevation angle and aircraft-attitude angle dependence from the solar-sky illumination measurement, and (2) to obtain data on the optical state of the atmosphere. The present sky reference is dependent on solar elevation and provides essentially no information on important atmospheric parameters. Two sky reference designs were tested. One system is built around a hyperbolic mirror and the reflection approach. A second approach to a sky reference utilizes a fish-eye lens to obtain a 180 deg field of view. A detailed re-design of the present sky reference around the fish-eye approach, even with its limitations, is recommended for the MSDS system. A preamplifier study was undertaken to find ways of improving the noise-equivalent reflectance by reducing the noise level for silicon detector channels on the MSDS.

Seven Pervasive Statistical Flaws in Cognitive Training Interventions

PubMed Central

Moreau, David; Kirk, Ian J.; Waldie, Karen E.

2016-01-01

The prospect of enhancing cognition is undoubtedly among the most exciting research questions currently bridging psychology, neuroscience, and evidence-based medicine. Yet, convincing claims in this line of work stem from designs that are prone to several shortcomings, thus threatening the credibility of training-induced cognitive enhancement. Here, we present seven pervasive statistical flaws in intervention designs: (i) lack of power; (ii) sampling error; (iii) continuous variable splits; (iv) erroneous interpretations of correlated gain scores; (v) single transfer assessments; (vi) multiple comparisons; and (vii) publication bias. Each flaw is illustrated with a Monte Carlo simulation to present its underlying mechanisms, gauge its magnitude, and discuss potential remedies. Although not restricted to training studies, these flaws are typically exacerbated in such designs, due to ubiquitous practices in data collection or data analysis. The article reviews these practices, so as to avoid common pitfalls when designing or analyzing an intervention. More generally, it is also intended as a reference for anyone interested in evaluating claims of cognitive enhancement. PMID:27148010

Computer system design description for SY-101 hydrogen mitigation test project data acquisition and control system (DACS-1)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ermi, A.M.

1997-05-01

Description of the Proposed Activity/REPORTABLE OCCURRENCE or PIAB: This ECN changes the computer systems design description support document describing the computers system used to control, monitor and archive the processes and outputs associated with the Hydrogen Mitigation Test Pump installed in SY-101. There is no new activity or procedure associated with the updating of this reference document. The updating of this computer system design description maintains an agreed upon documentation program initiated within the test program and carried into operations at time of turnover to maintain configuration control as outlined by design authority practicing guidelines. There are no new crediblemore » failure modes associated with the updating of information in a support description document. The failure analysis of each change was reviewed at the time of implementation of the Systems Change Request for all the processes changed. This document simply provides a history of implementation and current system status.« less

Superconducting Magnets for Accelerators

NASA Astrophysics Data System (ADS)

Brianti, G.; Tortschanoff, T.

1993-03-01

This chapter describes the main features of superconducting magnets for high energy synchrotrons and colliders. It refers to magnets presently used and under development for the most advanced accelerators projects, both recently constructed or in the preparatory phase. These magnets, using the technology mainly based on the NbTi conductor, are described from the aspect of design, materials, construction and performance. The trend toward higher performance can be gauged from the doubling of design field in less than a decade from about 4 T for the Tevatron to 10 T for the LHC. Special properties of the superconducting accelerator magnets, such as their general layout and the need of extensive computational treatment, the limits of performance inherent to the available conductors, the requirements on the structural design are described. The contribution is completed by elaborating on persistent current effects, quench protection and the cryostat design. As examples the main magnets for HERA and SSC, as well as the twin-aperture magnets for LHC, are presented.

Head-Up; An interdisciplinary, participatory and co-design process informing the development of a novel head and neck support for people living with progressive neck muscle weakness.

PubMed

Reed, Heath; Langley, Joe; Stanton, Andy; Heron, Nicola; Clarke, Zoe; Judge, Simon; McCarthy, Avril; Squire, Gill; Quinn, Ann; Wells, Oliver; Tindale, Wendy; Baxter, Susan; Shaw, Pamela J; McDermott, Christopher J

2014-01-01

This paper presents the Head-Up project, that aims to provide innovative head support to help improve posture, relieve pain and aid communication for people living with progressive neck muscle weakness. The initial focus is motor neurone disease. The case study illustrates collaborative, interdisciplinary research and new product development underpinned by participatory design. The study was initiated by a 2-day stakeholder workshop followed by early proof-of-concept modelling and patient need evidence building. The work subsequently led to a successful NIHR i4i application funding a 24-month iterative design process, patenting, CE marking and clinical evaluation. The evaluation has informed amendments to the proposed design refered to here as the Sheffield Support Snood (SSS). The outcome positively demonstrates use and performance improvements over current neck orthoses and the process of multidisciplinary and user engagement has created a sense of ownership by MND participants, who have since acted as advocates for the product.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchisio, Mario Andrea, E-mail: marchisio@hit.edu.cn

Published in 2008, Parts & Pools represents one of the first attempts to conceptualize the modular design of bacterial synthetic gene circuits with Standard Biological Parts (DNA segments) and Pools of molecules referred to as common signal carriers (e.g., RNA polymerases and ribosomes). The original framework for modeling bacterial components and designing prokaryotic circuits evolved over the last years and brought, first, to the development of an algorithm for the automatic design of Boolean gene circuits. This is a remarkable achievement since gene digital circuits have a broad range of applications that goes from biosensors for health and environment caremore » to computational devices. More recently, Parts & Pools was enabled to give a proper formal description of eukaryotic biological circuit components. This was possible by employing a rule-based modeling approach, a technique that permits a faithful calculation of all the species and reactions involved in complex systems such as eukaryotic cells and compartments. In this way, Parts & Pools is currently suitable for the visual and modular design of synthetic gene circuits in yeast and mammalian cells too.« less

The Langley Research Center CSI phase-0 evolutionary model testbed-design and experimental results

NASA Technical Reports Server (NTRS)

Belvin, W. K.; Horta, Lucas G.; Elliott, K. B.

1991-01-01

A testbed for the development of Controls Structures Interaction (CSI) technology is described. The design philosophy, capabilities, and early experimental results are presented to introduce some of the ongoing CSI research at NASA-Langley. The testbed, referred to as the Phase 0 version of the CSI Evolutionary model (CEM), is the first stage of model complexity designed to show the benefits of CSI technology and to identify weaknesses in current capabilities. Early closed loop test results have shown non-model based controllers can provide an order of magnitude increase in damping in the first few flexible vibration modes. Model based controllers for higher performance will need to be robust to model uncertainty as verified by System ID tests. Data are presented that show finite element model predictions of frequency differ from those obtained from tests. Plans are also presented for evolution of the CEM to study integrated controller and structure design as well as multiple payload dynamics.

Parametric study of potential early commercial MHD power plants

NASA Technical Reports Server (NTRS)

Hals, F. A.

1979-01-01

Three different reference power plant configurations were considered with parametric variations of the various design parameters for each plant. Two of the reference plant designs were based on the use of high temperature regenerative air preheaters separately fired by a low Btu gas produced from a coal gasifier which was integrated with the power plant. The third reference plant design was based on the use of oxygen enriched combustion air preheated to a more moderate temperature in a tubular type metallic recuperative heat exchanger which is part of the bottoming plant heat recovery system. Comparative information was developed on plant performance and economics. The highest net plant efficiency of about 45 percent was attained by the reference plant design with the use of a high temperature air preheater separately fired with the advanced entrained bed gasifier. The use of oxygen enrichment of the combustion air yielded the lowest cost of generating electricity at a slightly lower plant efficiency. Both of these two reference plant designs are identified as potentially attractive for early MHD power plant applications.

Endogenous avian leukosis viral loci in the Red Jungle Fowl genome assembly.

PubMed

Benkel, Bernhard; Rutherford, Katherine

2014-12-01

The current build (galGal4) of the genome of the ancestor of the modern chicken, the Red Jungle Fowl, contains a single endogenous avian leukosis viral element (ALVE) on chromosome 1 (designated RSV-LTR; family ERVK). The assembly shows the ALVE provirus juxtaposed with a member of a second family of avian endogenous retroviruses (designated GGERV20; family ERVL); however, the status of the 3' end of the ALVE element as well as its flanking region remain unclear due to a gap in the reference genome sequence. In this study, we filled the gap in the assembly using a combination of long-range PCR (LR-PCR) and a short contig present in the unassembled portion of the reference genome database. Our results demonstrate that the ALVE element (ALVE-JFevB) is inserted into the putative envelope region of a GGERV20 element, roughly 1 kbp from its 3' end, and that ALVE-JFevB is complete, and depending on its expression status, potentially capable of directing the production of virus. Moreover, the unassembled portion of the genome database contains junction fragments for a second, previously characterized endogenous proviral element, ALVE-6. ©2014 Poultry Science Association Inc.

Intra-coil interactions in split gradient coils in a hybrid MRI-LINAC system

NASA Astrophysics Data System (ADS)

Tang, Fangfang; Freschi, Fabio; Sanchez Lopez, Hector; Repetto, Maurizio; Liu, Feng; Crozier, Stuart

2016-04-01

An MRI-LINAC system combines a magnetic resonance imaging (MRI) system with a medical linear accelerator (LINAC) to provide image-guided radiotherapy for targeting tumors in real-time. In an MRI-LINAC system, a set of split gradient coils is employed to produce orthogonal gradient fields for spatial signal encoding. Owing to this unconventional gradient configuration, eddy currents induced by switching gradient coils on and off may be of particular concern. It is expected that strong intra-coil interactions in the set will be present due to the constrained return paths, leading to potential degradation of the gradient field linearity and image distortion. In this study, a series of gradient coils with different track widths have been designed and analyzed to investigate the electromagnetic interactions between coils in a split gradient set. A driving current, with frequencies from 100 Hz to 10 kHz, was applied to study the inductive coupling effects with respect to conductor geometry and operating frequency. It was found that the eddy currents induced in the un-energized coils (hereby-referred to as passive coils) positively correlated with track width and frequency. The magnetic field induced by the eddy currents in the passive coils with wide tracks was several times larger than that induced by eddy currents in the cold shield of cryostat. The power loss in the passive coils increased with the track width. Therefore, intra-coil interactions should be included in the coil design and analysis process.

An AK-LDMeans algorithm based on image clustering

NASA Astrophysics Data System (ADS)

Chen, Huimin; Li, Xingwei; Zhang, Yongbin; Chen, Nan

2018-03-01

Clustering is an effective analytical technique for handling unmarked data for value mining. Its ultimate goal is to mark unclassified data quickly and correctly. We use the roadmap for the current image processing as the experimental background. In this paper, we propose an AK-LDMeans algorithm to automatically lock the K value by designing the Kcost fold line, and then use the long-distance high-density method to select the clustering centers to further replace the traditional initial clustering center selection method, which further improves the efficiency and accuracy of the traditional K-Means Algorithm. And the experimental results are compared with the current clustering algorithm and the results are obtained. The algorithm can provide effective reference value in the fields of image processing, machine vision and data mining.

The status of membrane bioreactor technology.

PubMed

Judd, Simon

2008-02-01

In this article, the current status of membrane bioreactor (MBR) technology for wastewater treatment is reviewed. Fundamental facets of the MBR process and membrane and process configurations are outlined and the advantages and disadvantages over conventional suspended growth-based biotreatment are briefly identified. Key process design and operating parameters are defined and their significance explained. The inter-relationships between these parameters are identified and their implications discussed, with particular reference to impacts on membrane surface fouling and channel clogging. In addition, current understanding of membrane surface fouling and identification of candidate foulants is appraised. Although much interest in this technology exists and its penetration of the market will probably increase significantly, there remains a lack of understanding of key process constraints such as membrane channel clogging, and of the science of membrane cleaning.

Diagnostic workstation for digital hand atlas in bone age assessment

NASA Astrophysics Data System (ADS)

Cao, Fei; Huang, H. K.; Pietka, Ewa; Gilsanz, Vicente; Ominsky, Steven

1998-06-01

Bone age assessment by a radiological examination of a hand and wrist image is a procedure frequently performed in pediatric patients to evaluate growth disorders, determine growth potential in children and monitor therapy effects. The assessment method currently used in radiological diagnosis is based on atlas matching of the diagnosed hand image with the reference set of atlas patterns, which was developed in 1950s and is not fully applicable for children of today. We intent to implement a diagnostic workstation for creating a new reference set of clinically normal images which will serve as a digital atlas and can be used for a computer-assisted bone age assessment. In this paper, we present the initial data- collection and system setup phase of this five-year research program. We describe the system design, user interface implementation and software tool development for collection, visualization, management and processing of clinically normal hand and wrist images.

Teleology and teleonomy in behavior analysis

PubMed Central

Reese, Hayne W.

1994-01-01

Teleological descriptions and explanations refer to purpose as consequent to a phenomenon. They become nonteleological if purpose is represented as antecedent to the phenomenon. Such nonteleological statements are called teleonomic, especially when they refer to antecedent genetic “programs.” In behavior analysis, purpose is attributed to the organism's history of consequences. Such a history may leave a trace—physiological (mechanism) or mental (cognitivism)—or the issue of traces may be irrelevant (contextualism). The history or trace is antecedent to current responding, and thus is not a teleological concept in the classical sense. It could be called a teleonomic concept, but this designation is undesirable if it implies exclusively genetic programming, because the history or trace is genetically programmed in evolutionary selection but not in ontogenetic selection. Therefore, the concepts of teleology and teleonomy are not useful for behavior analysis, and invoking them can be misleading. The concept of purpose can be useful if it is not reified. PMID:22478174

The Effects of Real-Time Interactive Multimedia Teleradiology System

PubMed Central

Al-Safadi, Lilac

2016-01-01

This study describes the design of a real-time interactive multimedia teleradiology system and assesses how the system is used by referring physicians in point-of-care situations and supports or hinders aspects of physician-radiologist interaction. We developed a real-time multimedia teleradiology management system that automates the transfer of images and radiologists' reports and surveyed physicians to triangulate the findings and to verify the realism and results of the experiment. The web-based survey was delivered to 150 physicians from a range of specialties. The survey was completed by 72% of physicians. Data showed a correlation between rich interactivity, satisfaction, and effectiveness. The results of our experiments suggest that real-time multimedia teleradiology systems are valued by referring physicians and may have the potential for enhancing their practice and improving patient care and highlight the critical role of multimedia technologies to provide real-time multimode interactivity in current medical care. PMID:27294118

Rationale, Scenarios, and Profiles for the Application of the Internet Protocol Suite (IPS) in Space Operations

NASA Technical Reports Server (NTRS)

Benbenek, Daniel B.; Walsh, William

2010-01-01

This greenbook captures some of the current, planned and possible future uses of the Internet Protocol (IP) as part of Space Operations. It attempts to describe how the Internet Protocol is used in specific scenarios. Of primary focus is low-earth-orbit space operations, which is referred to here as the design reference mission (DRM). This is because most of the program experience drawn upon derives from this type of mission. Application profiles are provided. This includes parameter settings programs have proposed for sending IP datagrams over CCSDS links, the minimal subsets and features of the IP protocol suite and applications expected for interoperability between projects, and the configuration, operations and maintenance of these IP functions. Of special interest is capturing the lessons learned from the Constellation Program in this area, since that program included a fairly ambitious use of the Internet Protocol.

Testing new technologies for the LISA Gravitational Reference Senso

NASA Astrophysics Data System (ADS)

Conklin, John; Chilton, Andrew; Olatunde, Taiwo; Apple, Stephen; Ciani, Giacomo; Mueller, Guido

2015-01-01

LISA will directly observe low-frequency gravitational waves emitted by sources ranging from super-massive black hole mergers to compact galactic binaries. A laser interferometer will measure picometer changes in the distances between free falling test masses separated by millions of kilometers. A test mass and its associated sensing, actuation, charge control and caging subsystems are referred to as a gravitational reference sensor (GRS). The demanding acceleration noise requirement of < 3×10-15 m/sec2Hz1/2 for the LISA GRS has motivated a rigorous testing campaign in Europe and a dedicated technology mission, LISA Pathfinder, scheduled for launch in the summer of 2015. At the University of Florida we are developing a nearly thermally noise limited torsion pendulum for testing GRS technology enhancements and for understanding the dozens of acceleration noise sources that affect the performance of the GRS. This experimental facility is based on the design of a similar facility at the University of Trento, and consists of a vacuum enclosed torsion pendulum that suspends mock-ups of the LISA test masses, surrounded by electrode housings. Some of the technologies that will be demonstrated by this facility include a novel TM charge control scheme based on ultraviolet LEDs, an all-optical TM position and attitude sensor, and drift mode operation. This presentation will describe the design of the torsion pendulum facility, its current acceleration noise performance, and the status of the GRS technologies under development.

THE CONCEPT OF REFERENCE CONDITION, REVISITED ...

EPA Pesticide Factsheets

Ecological assessments of aquatic ecosystems depend on the ability to compare current conditions against some expectation of how they could be in the absence of significant human disturbance. The concept of a ‘‘reference condition’’ is often used to describe the standard or benchmark against which current condition is compared. If assessments are to be conducted consistently, then a common understanding of the definitions and complications of reference condition is necessary. A 2006 paper (Stoddard et al., 2006, Ecological Applications 16:1267-1276) made an early attempt at codifying the reference condition concept; in this presentation we will revisit the points raised in that paper (and others) and examine how our thinking has changed in a little over 10 years.Among the issues to be discussed: (1) the “moving target” created when reference site data are used to set thresholds in large scale assessments; (2) natural vs. human disturbance and their effects on reference site distributions; (3) circularity and the use of biological data to assist in reference site identification; (4) using site-scale (in-stream or in-lake) measurements vs. landscape-level human activity to identify reference conditions. Ecological assessments of aquatic ecosystems depend on the ability to compare current conditions against some expectation of how they could be in the absence of significant human disturbance. The concept of a ‘‘reference condition’’ is often use

A Low noise, Non-contact Capacitive Cardiac Sensor*

PubMed Central

Peng, GuoChen; Bocko, Mark F.

2014-01-01

The development of sensitive, non-contact electric field sensors to measure weak bioelectric signals will be useful for the development of a number of unobtrusive health sensors. In this paper we summarize our recent work on a number of specific challenges in the development of non-contact ECG sensors. First, we considered the design of a low noise sensor preamplifier. We have adapted circuit designs that incorporate a double feedback loop to cancel the input transistor leakage current while providing stable operation, fast settling time and good low frequency response without the need for ultrahigh value resistors. The measured input referred noise of the preamplifier in the frequency band 0.05–100 Hz is 0.76 μVrms, which is several times lower than existing ECG preamplifiers. PMID:23367049

Big issues, small systems: managing with information in medical research.

PubMed

Jones, J; Preston, H

2000-08-01

This subject of this article is the design of a database system for handling files related to the work of the Molecular Genetics Department of the International Blood Group Reference Laboratory. It examines specialist information needs identified within this organization and it indicates how the design of the Rhesus Information Tracking System was able to meet current needs. Rapid Applications Development prototyping forms the basis of the investigation, linked to interview, questionnaire, and observation techniques in order to establish requirements for interoperability. In particular, the place of this specialist database within the much broader information strategy of the National Blood Service will be examined. This unique situation is analogous to management activities in broader environments and a number of generic issues are highlighted by the research.

Flight Dynamics Analysis Branch 2005 Technical Highlights

NASA Technical Reports Server (NTRS)

2005-01-01

This report summarizes the major activities and accomplishments carried out by the Flight Dynamics Analysis Branch (FDAB), Code 595, in support of flight projects and technology development initiatives in Fiscal Year (FY) 2005. The report is intended to serve as a summary of the type of support carried out by the FDAB, as well as a concise reference of key accomplishments and mission experience derived from the various mission support roles. The primary focus of the FDAB is to provide expertise in the disciplines of flight dynamics including spacecraft navigation (autonomous and ground based); spacecraft trajectory design and maneuver planning; attitude analysis; attitude determination and sensor calibration; and attitude control subsystem (ACS) analysis and design. The FDAB currently provides support for missions and technology development projects involving NASA, other government agencies, academia, and private industry.

Low-power, high-speed 1-bit inexact Full Adder cell designs applicable to low-energy image processing

NASA Astrophysics Data System (ADS)

Zareei, Zahra; Navi, Keivan; Keshavarziyan, Peiman

2018-03-01

In this paper, three novel low-power and high-speed 1-bit inexact Full Adder cell designs are presented based on current mode logic in 32 nm carbon nanotube field effect transistor technology for the first time. The circuit-level figures of merits, i.e. power, delay and power-delay product as well as application-level metric such as error distance, are considered to assess the efficiency of the proposed cells over their counterparts. The effect of voltage scaling and temperature variation on the proposed cells is studied using HSPICE tool. Moreover, using MATLAB tool, the peak signal to noise ratio of the proposed cells is evaluated in an image-processing application referred to as motion detector. Simulation results confirm the efficiency of the proposed cells.

Preliminary design method for deployable spacecraft beams

NASA Technical Reports Server (NTRS)

Mikulas, Martin M., Jr.; Cassapakis, Costas

1995-01-01

There is currently considerable interest in low-cost, lightweight, compactly packageable deployable elements for various future missions involving small spacecraft. These elements must also have a simple and reliable deployment scheme and possess zero or very small free-play. Although most small spacecraft do not experience large disturbances, very low stiffness appendages or free-play can couple with even small disturbances and lead to unacceptably large attitude errors which may involve the introduction of a flexible-body control system. A class of structures referred to as 'rigidized structures' offers significant promise in providing deployable elements that will meet these needs for small spacecraft. The purpose of this paper is to introduce several rigidizable concepts and to develop a design methodology which permits a rational comparison of these elements to be made with alternate concepts.

Evaluation of the feasibility and viability of modular pumped storage hydro (m-PSH) in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witt, Adam M.; Hadjerioua, Boualem; Martinez, Rocio

The viability of modular pumped storage hydro (m-PSH) is examined in detail through the conceptual design, cost scoping, and economic analysis of three case studies. Modular PSH refers to both the compactness of the project design and the proposed nature of product fabrication and performance. A modular project is assumed to consist of pre-fabricated standardized components and equipment, tested and assembled into modules before arrival on site. This technology strategy could enable m-PSH projects to deploy with less substantial civil construction and equipment component costs. The concept of m-PSH is technically feasible using currently available conventional pumping and turbine equipment,more » and may offer a path to reducing the project development cycle from inception to commissioning.« less

An Overview of a Trajectory-Based Solution for En Route and Terminal Area Self-Spacing: Sixth Revision

NASA Technical Reports Server (NTRS)

Abbott, Terence S.

2015-01-01

This paper presents an overview of the sixth revision to an algorithm specifically designed to support NASA's Airborne Precision Spacing concept. This algorithm is referred to as the Airborne Spacing for Terminal Arrival Routes version 13 (ASTAR13). This airborne self-spacing concept contains both trajectory-based and state-based mechanisms for calculating the speeds required to achieve or maintain a precise spacing interval. The trajectory-based capability allows for spacing operations prior to the aircraft being on a common path. This algorithm was also designed specifically to support a standalone, non-integrated implementation in the spacing aircraft. This current revision to the algorithm adds the state-based capability in support of evolving industry standards relating to airborne self-spacing.

Broader autism phenotype in parents of autistic children: reality or myth?

PubMed

Scheeren, Anke M; Stauder, Johannes E A

2008-02-01

The finding that relatives of individuals with autism show mild autistic traits is referred to as the broader autism phenotype (BAP). In the current study, 25 parents with a child with high-functioning autism and 25 parents with typically developed children were compared on: (1) the Block Design Test, (2) the Autism-Spectrum Quotient (AQ), and (3) a reaction time task to examine reflexive covert visual orienting to social (eyes) and non-social (arrows) cues. The parent groups were scored similar on the Block Design Test and the AQ. However, fathers with an autistic child demonstrated a different reaction time pattern and responded slower on the social cues than control fathers. These results partly support and further elaborate on the BAP in parents with an autistic child.

Adversomics: a new paradigm for vaccine safety and design

PubMed Central

Whitaker, Jennifer A.; Ovsyannikova, Inna G.; Poland, Gregory A.

2015-01-01

Summary Despite the enormous population benefits of routine vaccination, vaccine adverse events and reactions, whether real or perceived, have posed one of the greatest barriers to vaccine acceptance—and thus to infectious disease prevention—worldwide. A truly integrated clinical, translational, and basic science approach is required to understand the mechanisms behind vaccine adverse events, predict them, and then apply this knowledge to new vaccine design approaches that decrease, or avoid, these events. The term “adversomics” was first introduced in 2009 and refers to the study of vaccine adverse reactions using immunogenomics and systems biology approaches. In this review, we present the current state of adversomics research, review known associations and mechanisms of vaccine adverse events/reactions, and outline a plan for the further development of this emerging research field. PMID:25937189

A low noise, non-contact capacitive cardiac sensor.

PubMed

Peng, GuoChen; Bocko, Mark F

2012-01-01

The development of sensitive, non-contact electric field sensors to measure weak bioelectric signals will be useful for the development of a number of unobtrusive health sensors. In this paper we summarize our recent work on a number of specific challenges in the development of non-contact ECG sensors. First, we considered the design of a low noise sensor preamplifier. We have adapted circuit designs that incorporate a double feedback loop to cancel the input transistor leakage current while providing stable operation, fast settling time and good low frequency response without the need for ultrahigh value resistors. The measured input referred noise of the preamplifier in the frequency band 0.05-100 Hz is 0.76 µV(rms), which is several times lower than existing ECG preamplifiers.

Electronic cigarettes: product characterisation and design considerations.

PubMed

Brown, Christopher J; Cheng, James M

2014-05-01

To review the available evidence regarding electronic cigarette (e-cigarette) product characterisation and design features in order to understand their potential impact on individual users and on public health. Systematic literature searches in 10 reference databases were conducted through October 2013. A total of 14 articles and documents and 16 patents were included in this analysis. Numerous disposable and reusable e-cigarette product options exist, representing wide variation in product configuration and component functionality. Common e-cigarette components include an aerosol generator, a flow sensor, a battery and a nicotine-containing solution storage area. e-cigarettes currently include many interchangeable parts, enabling users to modify the character of the delivered aerosol and, therefore, the product's 'effectiveness' as a nicotine delivery product. Materials in e-cigarettes may include metals, rubber and ceramics. Some materials may be aerosolised and have adverse health effects. Several studies have described significant performance variability across and within e-cigarette brands. Patent applications include novel product features designed to influence aerosol properties and e-cigarette efficiency at delivering nicotine. Although e-cigarettes share a basic design, engineering variations and user modifications result in differences in nicotine delivery and potential product risks. e-cigarette aerosols may include harmful and potentially harmful constituents. Battery explosions and the risks of exposure to the e-liquid (especially for children) are also concerns. Additional research will enhance the current understanding of basic e-cigarette design and operation, aerosol production and processing, and functionality. A standardised e-cigarette testing regime should be developed to allow product comparisons.

SIRTF Telescope Instrument Changeout and Cryogen Replenishment (STICCR) Study

NASA Technical Reports Server (NTRS)

Nast, T. C.; Frank, D.; Liu, C. K.; Parmley, R. T.; Jaekle, D.; Builteman, H.; Schmidt, J.; Frederking, T. H. K.

1985-01-01

The Space Infrared Telescope Facility (SIRTF) is a long-life cryogenically cooled space-based telescope for infrared astronomy from 2 to 700 micrometers. SIRTF is currently under study by NASA-ARC (Reference AP) and planned for launch in approximately the mid 1990s. SIRTF will operate as a multiuser facility, initially carrying three instruments at the focal plane. It will be cooled to below 2 K by superfluid liquid helium to achieve radiometric sensitivity limited only by the statistical fluctuations in the natural infrared background radiation over most of its spectral range. The lifetime of the mission will be limited by the lifetime of the liquid helium supply, and baseline is currently to be 2 years. The telescope changes required to allow in-space replenishment of the 4,000-L superfluid helium tank was investigated. A preliminary design for the space services equipment was also developed. The impacts of basing the equipment and servicing on the space station were investigated. Space replenishment and changeout of instruments required changes to the telescope design. Preliminary concepts are presented.

Coordinating IMC-PID and adaptive SMC controllers for a PEMFC.

PubMed

Wang, Guo-Liang; Wang, Yong; Shi, Jun-Hai; Shao, Hui-He

2010-01-01

For a Proton Exchange Membrane Fuel Cell (PEMFC) power plant with a methanol reformer, the process parameters and power output are considered simultaneously to avoid violation of the constraints and to keep the fuel cell power plant safe and effective. In this paper, a novel coordinating scheme is proposed by combining an Internal Model Control (IMC) based PID Control and adaptive Sliding Mode Control (SMC). The IMC-PID controller is designed for the reformer of the fuel flow rate according to the expected first-order dynamic properties. The adaptive SMC controller of the fuel cell current has been designed using the constant plus proportional rate reaching law. The parameters of the SMC controller are adaptively tuned according to the response of the fuel flow rate control system. When the power output controller feeds back the current references to these two controllers, the coordinating controllers system works in a system-wide way. The simulation results of the PEMFC power plant demonstrate the effectiveness of the proposed method. 2009 ISA. Published by Elsevier Ltd. All rights reserved.

Current Technology Development Efforts on the International X-Ray Observatory

NASA Technical Reports Server (NTRS)

Robinson, David

2011-01-01

The International X-ray Observatory (IXO) is a collaboration between NASA, ESA, and JAXA which is under study for launch in 2021. IXO will be a large 6600 kilogram Great Observatory-class mission which will build upon the legacies of the Chandra and XMM-Newton X-ray observatories. There is an extensive ongoing effort to raise the technology readiness level of the X-ray mirror from TRL 3 to TRL 6 in the next decade. Improvements have recently been made in the area of positioning and bonding mirrors on the nanometer scale and developing metals and composites with a matching coefficient of thermal expansion to the glass X-ray mirrors. On the mission systems side, the NASA reference design has been through a preliminary coupled loads analysis and a STOP analysis of the flight mirror assembly has been initiated. An impact study was performed comparing launching IXO on an Ariane 5 or a U.S. EELV. This paper will provide a snapshot of NASA's current observatory configuration and summarize the progress of these various technology and design efforts.

NASA CEV Reference Entry GN&C System and Analysis

NASA Technical Reports Server (NTRS)

Munday, S.; Madsen, C.; Broome, J.; Gay, R.; Tigges, M.; Strahan, A.

2007-01-01

As part of its overall objectives, the Orion spacecraft will be required to perform entry and Earth landing functions for Low Earth Orbit (LEO) and Lunar missions. Both of these entry scenarios will begin with separation of the Service Module (SM), making them unique from other Orion mission phases in that only the Command Module (CM) portion of the Crew Exploration Vehicle (CEV) will be involved, requiring a CM specific Guidance, Navigation and Control (GN&C) system. Also common to these mission scenarios will be the need for GN&C to safely return crew (or cargo) to earth within the dynamic thermal and structural constraints of entry and within acceptable accelerations on the crew, utilizing the limited aerodynamic performance of the CM capsule. The lunar return mission could additionally require an initial atmospheric entry designed to support a precision skip and second entry, all to maximize downrange performance and ensure landing in the United States. This paper describes the Entry GN&C reference design, developed by the NASA-led team, that supports these entry scenarios and that was used to validate the Orion System requirements. Description of the reference design will include an overview of the GN&C functions, avionics, and effectors and will relate these to the specific design drivers of the entry scenarios, as well as the desire for commonality in vehicle systems to support the different missions. The discussion will also include the requirement for an Emergency Entry capability beyond that of the nominal performance of the multi-string GNC system, intended to return the crew to the earth in a survivable but unguided manner. Finally, various analyses will be discussed, including those completed to support validation efforts of the current CEV requirements, along with those on-going and planned with the intention to further refine the requirements and to support design development work in conjunction with the prime contractor. Some of these ongoing analyses will include work to size effectors (jets) and fuel budgets, to refine skip entry concepts, to characterize navigation performance and uncertainties, to provide for SM disposal offshore and to identify requirements to support target site selection.

ATHENA: system design and implementation for a next generation x-ray telescope

NASA Astrophysics Data System (ADS)

Ayre, M.; Bavdaz, M.; Ferreira, I.; Wille, E.; Lumb, D.; Linder, M.

2015-08-01

ATHENA, Europe's next generation x-ray telescope, has recently been selected for the 'L2' slot in ESA's Cosmic Vision Programme, with a mandate to address the 'Hot and Energetic Universe' Cosmic Vision science theme. The mission is currently in the Assessment/Definition Phase (A/B1), with a view to formal adoption after a successful System Requirements Review in 2019. This paper will describe the reference mission architecture and spacecraft design produced during Phase 0 by the ESA Concurrent Design Facility (CDF), in response to the technical requirements and programmatic boundary conditions. The main technical requirements and their mapping to resulting design choices will be presented, at both mission and spacecraft level. An overview of the spacecraft design down to subsystem level will then be presented (including the telescope and instruments), remarking on the critically-enabling technologies where appropriate. Finally, a programmatic overview will be given of the on-going Assessment Phase, and a snapshot of the prospects for securing the `as-proposed' mission within the cost envelope will be given.

Power Lander for Support of Long-Term Lunar Presence

NASA Technical Reports Server (NTRS)

Joyner, Russ; Rodriguez, Gary

2004-01-01

Emerging industrial base and the consequent sustained manned Lunar presence will require consistent high power capacities. This paper proposes a first iteration design of a flyable electric power platform which could serve as an enabler of Lunar Development and Exploration. It is intended to support a small facility solo or an emerging industrial base as part of a grid. Lunar Missions, Habitats and Facilities stand to benefit from an expected decade of non-stop operation, the economics of scale, Commercial Off-The-Shelf (COTS) availability, standardization of design, and logistical support for Lunar encampments provided by this architecture. The unattended and unmanned vehicle design is to be man- and robotics-serviceable after delivery by current and proposed heavy-lift boosters. Design continuity within a family of systems will improve reliability through "lessons learned'' in the field. Further, various configurations of the proposed scalable architecture will provide reference platforms for the indigenous construction of similar power plant facilities from in-situ Lunar resources (ISRU). The baseline design should be directed towards those materials available on the Moon and expected to be manufacturable on-site within the first decade of operation.

[Saarland Growth Study: sampling design].

PubMed

Danker-Hopfe, H; Zabransky, S

2000-01-01

The use of reference data to evaluate the physical development of children and adolescents is part of the daily routine in the paediatric ambulance. The construction of such reference data is based on the collection of extensive reference data. There are different kinds of reference data: cross sectional references, which are based on data collected from a big representative cross-sectional sample of the population, longitudinal references, which are based on follow-up surveys of usually smaller samples of individuals from birth to maturity, and mixed longitudinal references, which are a combination of longitudinal and cross-sectional reference data. The advantages and disadvantages of the different methods of data collection and the resulting reference data are discussed. The Saarland Growth Study was conducted for several reasons: growth processes are subject to secular changes, there are no specific reference data for children and adolescents from this part of the country and the growth charts in use in the paediatric praxis are possibly not appropriate any more. Therefore, the Saarland Growth Study served two purposes a) to create actual regional reference data and b) to create a database for future studies on secular trends in growth processes of children and adolescents from Saarland. The present contribution focusses on general remarks on the sampling design of (cross-sectional) growth surveys and its inferences for the design of the present study.

Multistate approaches in computational protein design

PubMed Central

Davey, James A; Chica, Roberto A

2012-01-01

Computational protein design (CPD) is a useful tool for protein engineers. It has been successfully applied towards the creation of proteins with increased thermostability, improved binding affinity, novel enzymatic activity, and altered ligand specificity. Traditionally, CPD calculations search and rank sequences using a single fixed protein backbone template in an approach referred to as single-state design (SSD). While SSD has enjoyed considerable success, certain design objectives require the explicit consideration of multiple conformational and/or chemical states. Cases where a “multistate” approach may be advantageous over the SSD approach include designing conformational changes into proteins, using native ensembles to mimic backbone flexibility, and designing ligand or oligomeric association specificities. These design objectives can be efficiently tackled using multistate design (MSD), an emerging methodology in CPD that considers any number of protein conformational or chemical states as inputs instead of a single protein backbone template, as in SSD. In this review article, recent examples of the successful design of a desired property into proteins using MSD are described. These studies employing MSD are divided into two categories—those that utilized multiple conformational states, and those that utilized multiple chemical states. In addition, the scoring of competing states during negative design is discussed as a current challenge for MSD. PMID:22811394

A simple novel device for air sampling by electrokinetic capture

DOE PAGES

Gordon, Julian; Gandhi, Prasanthi; Shekhawat, Gajendra; ...

2015-12-27

A variety of different sampling devices are currently available to acquire air samples for the study of the microbiome of the air. All have a degree of technical complexity that limits deployment. Here, we evaluate the use of a novel device, which has no technical complexity and is easily deployable. An air-cleaning device powered by electrokinetic propulsion has been adapted to provide a universal method for collecting samples of the aerobiome. Plasma-induced charge in aerosol particles causes propulsion to and capture on a counter-electrode. The flow of ions creates net bulk airflow, with no moving parts. A device and electrodemore » assembly have been re-designed from air-cleaning technology to provide an average air flow of 120 lpm. This compares favorably with current air sampling devices based on physical air pumping. Capture efficiency was determined by comparison with a 0.4 μm polycarbonate reference filter, using fluorescent latex particles in a controlled environment chamber. Performance was compared with the same reference filter method in field studies in three different environments. For 23 common fungal species by quantitative polymerase chain reaction (qPCR), there was 100 % sensitivity and apparent specificity of 87%, with the reference filter taken as “gold standard.” Further, bacterial analysis of 16S RNA by amplicon sequencing showed equivalent community structure captured by the electrokinetic device and the reference filter. Unlike other current air sampling methods, capture of particles is determined by charge and so is not controlled by particle mass. We analyzed particle sizes captured from air, without regard to specific analyte by atomic force microscopy: particles at least as low as 100 nM could be captured from ambient air. This work introduces a very simple plug-and-play device that can sample air at a high-volume flow rate with no moving parts and collect particles down to the sub-micron range. In conclusion, the performance of the device is substantially equivalent to capture by pumping through a filter for microbiome analysis by quantitative PCR and amplicon sequencing.« less

A simple novel device for air sampling by electrokinetic capture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordon, Julian; Gandhi, Prasanthi; Shekhawat, Gajendra

A variety of different sampling devices are currently available to acquire air samples for the study of the microbiome of the air. All have a degree of technical complexity that limits deployment. Here, we evaluate the use of a novel device, which has no technical complexity and is easily deployable. An air-cleaning device powered by electrokinetic propulsion has been adapted to provide a universal method for collecting samples of the aerobiome. Plasma-induced charge in aerosol particles causes propulsion to and capture on a counter-electrode. The flow of ions creates net bulk airflow, with no moving parts. A device and electrodemore » assembly have been re-designed from air-cleaning technology to provide an average air flow of 120 lpm. This compares favorably with current air sampling devices based on physical air pumping. Capture efficiency was determined by comparison with a 0.4 μm polycarbonate reference filter, using fluorescent latex particles in a controlled environment chamber. Performance was compared with the same reference filter method in field studies in three different environments. For 23 common fungal species by quantitative polymerase chain reaction (qPCR), there was 100 % sensitivity and apparent specificity of 87%, with the reference filter taken as “gold standard.” Further, bacterial analysis of 16S RNA by amplicon sequencing showed equivalent community structure captured by the electrokinetic device and the reference filter. Unlike other current air sampling methods, capture of particles is determined by charge and so is not controlled by particle mass. We analyzed particle sizes captured from air, without regard to specific analyte by atomic force microscopy: particles at least as low as 100 nM could be captured from ambient air. This work introduces a very simple plug-and-play device that can sample air at a high-volume flow rate with no moving parts and collect particles down to the sub-micron range. In conclusion, the performance of the device is substantially equivalent to capture by pumping through a filter for microbiome analysis by quantitative PCR and amplicon sequencing.« less

Current Trends and Challenges in Satellite Laser Ranging

NASA Astrophysics Data System (ADS)

Appleby, Graham M.; Bianco, Giuseppe; Noll, Carey E.; Pavlis, Erricos C.; Pearlman, Michael R.

2016-12-01

Satellite Laser Ranging (SLR) is used to measure accurately the distance from ground stations to retro-reflectors on satellites and on the Moon. SLR is one of the fundamental space-geodetic techniques that define the International Terrestrial Reference Frame (ITRF), which is the basis upon which many aspects of global change over space, time, and evolving technology are measured; with VLBI the two techniques define the scale of the ITRF; alone the SLR technique defines its origin (geocenter). The importance of the reference frame has recently been recognized at the inter-governmental level through the United Nations, which adopted in February 2015 the Resolution "Global Geodetic Reference Frame for Sustainable Development." Laser Ranging provides precision orbit determination and instrument calibration and validation for satellite-borne altimeters for the better understanding of sea level change, ocean dynamics, ice mass-balance, and terrestrial topography. It is also a tool to study the dynamics of the Moon and fundamental constants and theories. With the exception of the currently in-orbit GPS constellation, all GNSS satellites now carry retro-reflectors for improved orbit determination, harmonization of reference frames, and in-orbit co-location and system performance validation; the next generation of GPS satellites due for launch from 2019 onwards will also carry retro-reflectors. The ILRS delivers weekly realizations that are accumulated sequentially to extend the ITRF and the Earth Orientation Parameter series with a daily resolution. SLR technology continues to evolve towards the next-generation laser ranging systems and it is expected to successfully meet the challenges of the GGOS2020 program for a future Global Space Geodetic Network. Ranging precision is improving as higher repetition rate, narrower pulse lasers, and faster detectors are implemented within the network. Automation and pass interleaving at some stations is expanding temporal coverage and greatly enhancing efficiency. Discussions are ongoing with some missions that will allow the SLR network stations to provide crucial, but energy-safe, range measurements to optically vulnerable satellites. New retro-reflector designs are improving the signal link and enable daylight ranging that is now the norm for many stations. We discuss many of these laser ranging activities and some of the tough challenges that the SLR network currently faces.

A simple novel device for air sampling by electrokinetic capture.

PubMed

Gordon, Julian; Gandhi, Prasanthi; Shekhawat, Gajendra; Frazier, Angel; Hampton-Marcell, Jarrad; Gilbert, Jack A

2015-12-27

A variety of different sampling devices are currently available to acquire air samples for the study of the microbiome of the air. All have a degree of technical complexity that limits deployment. Here, we evaluate the use of a novel device, which has no technical complexity and is easily deployable. An air-cleaning device powered by electrokinetic propulsion has been adapted to provide a universal method for collecting samples of the aerobiome. Plasma-induced charge in aerosol particles causes propulsion to and capture on a counter-electrode. The flow of ions creates net bulk airflow, with no moving parts. A device and electrode assembly have been re-designed from air-cleaning technology to provide an average air flow of 120 lpm. This compares favorably with current air sampling devices based on physical air pumping. Capture efficiency was determined by comparison with a 0.4 μm polycarbonate reference filter, using fluorescent latex particles in a controlled environment chamber. Performance was compared with the same reference filter method in field studies in three different environments. For 23 common fungal species by quantitative polymerase chain reaction (qPCR), there was 100 % sensitivity and apparent specificity of 87 %, with the reference filter taken as "gold standard." Further, bacterial analysis of 16S RNA by amplicon sequencing showed equivalent community structure captured by the electrokinetic device and the reference filter. Unlike other current air sampling methods, capture of particles is determined by charge and so is not controlled by particle mass. We analyzed particle sizes captured from air, without regard to specific analyte by atomic force microscopy: particles at least as low as 100 nM could be captured from ambient air. This work introduces a very simple plug-and-play device that can sample air at a high-volume flow rate with no moving parts and collect particles down to the sub-micron range. The performance of the device is substantially equivalent to capture by pumping through a filter for microbiome analysis by quantitative PCR and amplicon sequencing.

Preliminary test results of electrical charged particle generator for application to fog dispersal

NASA Technical Reports Server (NTRS)

Frost, W.

1982-01-01

A charged particle generator for use in fog dispersal applications was built and preliminary tests were carried out. The parameter used as a measure of performance was the current measured with a needle probe positioned in the charged jet connected to ground through an ammeter. The needle was movable and allowed the current profile throughout the jet to be determined. The measured current is referred to as the current output. The major independent parameters were liquid water injection rate, plenum pressure, and corona voltage. Optimum current output was achieved at the approximate pressure of 30 psig, corona voltage of 5600 volts, and liquid water injection rate of 6 cc/min. The results of the test with the prototype charged particle generator clearly demonstrate that a current on the order of 20 microamperes can be routinely achieved with the system. This measurement of current does not necessarily represent the total issuing from the nozzle current which is expected to be larger. From these results, confidence was established that a charged particle generator which will operate continuously and consistently can be designed, constructed, and operated. Further work is required, however, to better understand the physical mechanisms involved and to optimize the system for fog dispersal application.

Comparing The Effects Of Reference Pricing And Centers-Of-Excellence Approaches To Value-Based Benefit Design.

PubMed

Zhang, Hui; Cowling, David W; Facer, Matthew

2017-12-01

Various health insurance benefit designs based on value-based purchasing have been promoted to steer patients to high-value providers, but little is known about the designs' relative effectiveness and underlying mechanisms. We compared the impact of two designs implemented by the California Public Employees' Retirement System on inpatient hospital total hip or knee replacement: a reference-based pricing design for preferred provider organizations (PPOs) and a centers-of-excellence design for health maintenance organizations (HMOs). Payment and utilization data for the procedures in the period 2008-13 were evaluated using pre-post and quasi-experimental designs at the system and health plan levels, adjusting for demographic characteristics, case-mix, and other confounders. We found that both designs prompted higher use of designated low-price high-quality facilities and reduced average replacement expenses per member at the plan and system levels. However, the designs used different routes: The reference-based pricing design reduced average replacement payments per case in PPOs by 26.7 percent in the first year, compared to HMOs, but did not lower PPO members' utilization rates. In contrast, the centers-of-excellence design lowered HMO members' utilization rates by 29.2 percent in the first year, compared to PPOs, but did not reduce HMO average replacement payments per case. The reference-based pricing design appears more suitable for reducing price variation, and the centers-of-excellence design for addressing variation in use.

International Space Station Evolution Data Book. Volume 2; Evolution Concepts; Revised

NASA Technical Reports Server (NTRS)

Jorgensen, Catherine A. (Editor); Antol, Jeffrey (Technical Monitor)

2000-01-01

This report provides a focused and in-depth look at the opportunities and drivers for the enhancement and evolution of the International Space Station (ISS) during assembly and beyond the assembly complete stage. These enhancements would expand and improve the current baseline capabilities of the ISS and help to facilitate the commercialization of the ISS by the private sector. Volume 1 provides the consolidated overview of the ISS baseline systems; information on the current facilities available for pressurized and unpressurized payloads; and information on current plans for crew availability and utilization, resource timelines and margin summaries including power, thermal, and storage volumes; and an overview of the vehicle traffic model. Volume 2 includes discussions of advanced technologies being investigated for use on the ISS and potential commercial utilization activities being examined including proposed design reference missions (DRM's) and the technologies being assessed by the Pre-planned Program Improvement (P(sup 3) I) Working Group. This information is very high level and does not provide the relevant information necessary for detailed design efforts. This document is meant to educate readers on the ISS and to stimulate the generation of ideas for enhancement and utilization of the ISS, either by or for the government, academia, and commercial industry.

Putting "Reference" in the Publications Reference File.

ERIC Educational Resources Information Center

Zink, Steven D.

1980-01-01

Argues for more widespread utilization of the U.S. Government Printing Office's Publications Reference File, a reference tool in microfiche format used to answer questions about current U.S. government documents and their availability. Ways to accomplish this task are suggested. (Author/JD)

4D Dynamic RNP Annual Interim Report-Year 1

NASA Technical Reports Server (NTRS)

Finkelsztein, Daniel M.; Sturdy, James L.; Alaverdi, Omeed; Chung, William W.; Salvano, Daniel; Klooster, Joel; Hochwarth, Joachim K.

2010-01-01

This Annual Interim Report summarizes the activities led by Raytheon, in collaboration with GE Aviation and SAIC, and presents the results obtained during the first year of this research effort to expand the RNP concept to 4 dimensions relative to a dynamic frame of reference. Joint Program Development Office (JPDO)Concepts of Operations for the Next Generation Air Transportation System (NextGen) considers 4 Dimension Trajectory (4DT) procedures a key enabler to Trajectory Based Operations (TBO). The JPDO defines 4DT as a precise description of an aircraft path in space and time . While NextGen assumes that this path is defined within an Earth-reference frame, many 4DT procedure implementations will require an aircraft to precisely navigate relative to a moving reference such as another aircraft to form aggregate flows or a weather cell to allow for flows to shift. Current methods of implementing routes and flight paths rely on aircraft meeting a Required Navigation Performance (RNP) specification and being equipped with a monitoring and alerting capability to annunciate when the aircraft system is unable to meet the performance specification required for the operation. Since all aircraft today operate within the NAS relative to fixed reference points, the current RNP definition is deemed satisfactory. However, it is not well understood how the current RNP construct will support NextGen 4DT procedures where aircraft operate relative to each other or to other dynamic frames of reference. The objective of this research effort is to analyze candidate 4DT procedures from both an Air Navigation Service Provider (ANSP) and aircraft perspective, to identify their specific navigational requirements, assess the shortcomings of the current RNP construct to meet these requirements, to propose an extended 4 Dimensional Dynamic RNP (4D Dynamic RNP) construct that accounts for the dynamic spatial and temporal nature of the selected 4DT procedures, and finally, to design an experiment using the Airspace and Traffic Operations Simulation (ATOS) system to validate the 4D Dynamic RNP construct. This Annual Interim Report summarizes the activities led by Raytheon, in collaboration with GE Aviation and SAIC, and presents the results obtained during the first year of this research effort to expand the RNP concept to 4 dimensions relative to a dynamic frame of reference. A comprehensive assessment of the state-of-the-art international implementation of current RNP was completed and presented in the Contractor Report RNP State-of-the-Art Assessment, Version 4, 17 December 2008 . The team defined in detail two 4DT operations, Airborne Precision Spacing and Self-Separation, that are ideally suited to be supported by 4D Dynamic RNP and developed their respective conceptual frameworks, Required Interval Management Performance (RIMP) Version 1.1, 13 April 2009 and Required Self Separation Performance (RSSP) Version 1.1, 13 April 2009 . Finally, the team started the development of a mathematical model and simulation tool for RIMP and RSSP scheduled to be delivered during the second year of this research effort.

Estimating pixel variances in the scenes of staring sensors

DOEpatents

Simonson, Katherine M [Cedar Crest, NM; Ma, Tian J [Albuquerque, NM

2012-01-24

A technique for detecting changes in a scene perceived by a staring sensor is disclosed. The technique includes acquiring a reference image frame and a current image frame of a scene with the staring sensor. A raw difference frame is generated based upon differences between the reference image frame and the current image frame. Pixel error estimates are generated for each pixel in the raw difference frame based at least in part upon spatial error estimates related to spatial intensity gradients in the scene. The pixel error estimates are used to mitigate effects of camera jitter in the scene between the current image frame and the reference image frame.

Preliminary Evaluation of Alternate Designs for HFIR Low-Enriched Uranium Fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renfro, David; Chandler, David; Cook, David

2014-10-30

Engineering design studies of the feasibility of conversion of the High Flux Isotope Reactor (HFIR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel are ongoing at Oak Ridge National Laboratory (ORNL) as part of an effort sponsored by the U.S. Department of Energy’s Global Threat Reduction Initiative (GTRI)/Reduced Enrichment for Research and Test Reactors (RERTR) program. The fuel type selected by the program for the conversion of the five high-power research reactors in the U.S. that still use HEU fuel is a new U-Mo monolithic fuel. Studies by ORNL have previously indicated that HFIR can be successfully converted usingmore » the new fuel provided (1) the reactor power can be increased from 85 MW to 100 MW and (2) the fuel can be fabricated to a specific reference design. Fabrication techniques for the new fuel are under development by the program but are still immature, especially for the “complex” aspects of the HFIR fuel design. In FY 2012, the program underwent a major shift in focus to emphasize developing and qualifying processes for the fabrication of reliable and affordable LEU fuel. In support of this new focus and in an effort to ensure that the HFIR fuel design is as suitable for reliable fabrication as possible, ORNL undertook the present study to propose and evaluate several alternative design features. These features include (1) eliminating the fuel zone axial contouring in the previous reference design by substituting a permanent neutron absorber in the lower unfueled region of all of the fuel plates, (2) relocating the burnable neutron absorber from the fuel plates of the inner fuel element to the side plates of the inner fuel element (the fuel plates of the outer fuel element do not contain a burnable absorber), (3) relocating the fuel zone inside the fuel plate to be centered on the centerline of the depth of the plate, and (4) reshaping the radial contour of the relocated fuel zone to be symmetric about this centerline. The present studies used current analytical tools to evaluate the various alternate designs for cycle length, scientific performance (e.g., neutron scattering), and steady-state and transient thermal performance using both safety limit and nominal parameter assumptions. The studies concluded that a new reference design combining a permanent absorber in the lower unfueled region of all of the fuel plates, a burnable absorber in the inner element side plates, and a relocated and reshaped (but still radially contoured) fuel zone will allow successful conversion of HFIR. Future collaboration with the program will reveal whether the new reference design can be fabricated reliably and affordably. Following this feedback, additional studies using state-of-the-art developmental analytical tools are proposed to optimize the design of the fuel zone radial contour and the amount and location of both types of neutron absorbers to further flatten thermal peaks while maximizing the performance of the reactor.« less

Frequent attenders in general practice care: a literature review with special reference to methodological considerations.

PubMed

Vedsted, P; Christensen, M B

2005-02-01

To describe the basis on which our knowledge of frequent attendance in general practice rests and to propose recommendations for further research on frequent attenders (FAs). The literature review (finished February 2004) encompassed peer-reviewed articles in English describing contacts with general practice in terms of frequency. Searches were performed in the Medline, CINAHL, EMBASE, PsycINFO, Social Sciences Expanded Index and ISI Citation databases with additional searches in reference lists and the 'related articles' function in the ISI Citation database and Medline. General practice. Sixty-one articles (54 studies). The articles were assessed according to the following design variables: setting; definition of FAs; sampling; sample size; control groups; study aim; study design; data sources; effect measure; and main results. There was no generally accepted definition of frequent attendance. Research designs differed substantially. Eight articles gave sufficient information on all design variables. The top 10% of attenders accounted for 30-50% of all contacts, and up to 40% of FAs were still FAs the following year. More than 50% of FAs had a physical disease, more than 50% of FAs suffered from psychological distress, social factors (low social support, unemployment, divorce) were associated with frequent attendance in more than 50% of FAs, multiproblems (physical, psychological and social) were found in one-third of FAs, and frequent attendance was associated with increasing age and female gender. The diversity of designs, definitions and methods in the current literature on FAs in general practice hampers comparison of their precision, validity and generalizability, and calls for cautious interpretation and adoption of a common, generally acceptable definition in future studies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gaballa, H; O’Brien, M; Riegel, A

Purpose: To develop a daily quality assurance (QA) device that can test the 6DoF (degrees of freedom) couch repositioning accuracy, prior to SBRT treatment deliveries, with an accuracy of ±0.3 degrees and ±0.3 mm. Methods: A daily QA phantom is designed with a focus on the derived center of projections of its markers, rather than tracking its individual markers one at a time. This approach can be the most favorable to address the intended machining accuracy of the QA phantom and the CBCT spatial resolution limitations, primarily 1 mm min slice thickness, simultaneously. With the current design, ±0.1 mm congruencemore » of the resultant center of gravity of the markers with reference CT (0.6 mm minimum slice thickness) vs CBCT (1.0 mm minimum slice thickness) can be achieved. If successful, the QA device should be qualified to test 6DoF couch performance with a gauged accuracy of ±0.3 degrees/±0.3 mm. Testing is performed for the Varian True Beam 2.0 6DoF system. Results: Once the QA phantom is constructed and tested, agreement of the center of gravity of the reference CT scan and the CBCT scan of ±0.1 mm is achieved. This has translated into a consistent 3D-3D match on the treatment machine, CT vs CBCT, with a repetitive ±0.1 mm variation, thus exceeding our expectations. We have deployed the phantom for daily QA on one of our accelerators, and found that the QA time has increased by only 10 minutes. Conclusion: A 6DoF phantom has been designed (patent pending) and built with a realistic work flow in mind where the daily couch accuracy QA checks taking less than 10 minutes. Current developments include integration with the Varian’s Machine Performance Check consistency module.« less

The influence of ergonomic factors and perceptual-motor abilities on handwriting performance.

PubMed

Tseng, M H; Cermak, S A

1993-10-01

Difficulty with handwriting is one of the most frequent reasons that children in the public schools are referred to occupational therapy. Current research on the influence of ergonomic factors, such as pencil grip and pressure, and perceptual-motor factors traditionally believed to affect handwriting, is reviewed. Factors such as visual perception show little relationship to handwriting, whereas tactile-kinesthetic, visual-motor, and motor planning appear to be more closely related to handwriting. By better understanding the ergonomic and perceptual-motor factors that contribute to and influence handwriting, therapists will be better able to design rationally based intervention programs.

Manned Mars mission health maintenance facility

NASA Technical Reports Server (NTRS)

Degioanni, Joseph C.

1986-01-01

The Health Maintenance Facility (HMF) requirements which enable/enhance manned Mars missions (MMMs) are addressed. It does not attempt to resolve any issues that may affect the feasibility of any given element in the HMF. Reference is made to current work being conducted in the design of the space station HMF. The HMF requirements are discussed within the context of two distinctly different scenarios: HMF as part of the Mars surface infrastructure, and HMF as part of the nine months translation from low Earth orbit to Mars orbit. Requirements for an HMF are provided, and a concept of HMF is shown.

Design and Implementation of a Numerical Technique to Inform Anisotropic Hyperelastic Finite Element Models using Diffusion-Weighted Imaging

DTIC Science & Technology

2011-10-01

the deviatoric part of a tensor in the reference configuration and p = −∂Ψ ∂J is the hydrostatic pressure. Using the chain 4 rule, equation 13 can be...Kirchoff stress tensor S to the current configuration, and a scaling with the inverse of the volume ratio, transforms equation 16 to the Cauchy stress ...a characteristic of most soft tissues. Then, similar to equation 13, the second Piola-Kirchoff stress is given by: S = 2J−2/3DEV [ ∂Ψisoc ( C ) ∂C

Publication search and retrieval system

USGS Publications Warehouse

Winget, Elizabeth A.

1981-01-01

The publication search and retrieval system of the Branch of Atlantic-Gulf of Mexico Geology, U.S. Geological Survey, Woods Hole, Mass., is a procedure for listing and describing branch-sponsored publications. It is designed for maintenance and retrieval by those having limited knowledge of computer languages and programs. Because this branch currently utilizes the Hewlett-Packard HP-1000 computer with RTE-IVB operating system, database entry and maintenance is performed in accordance with the TE-IVB Terminal User’s Reference Manual (Hewlett-Packard Company, 1980) and within the constraints of GRASP (Bowen and Botbol, 1975) and WOLF (Evenden, 1978).

Thermal properties of alkali-activated aluminosilicates

NASA Astrophysics Data System (ADS)

Florian, Pavel; Valentova, Katerina; Fiala, Lukas; Zmeskal, Oldrich

2017-07-01

The paper is focused on measurements and evaluation of thermal properties of alkali-activated aluminosilicates (AAA) with various carbon admixtures. Such composites consisting of blast-furnace slag, quartz sand, water glass as alkali activator and small amount of electrically conductive carbon admixture exhibit better electric and thermal properties than the reference material. Such enhancement opens up new practical applications, such as designing of snow-melting, de-icing or self-sensing systems that do not need any external sensors to detect current condition of building material. Thermal properties of the studied materials were measured by the step-wise transient method and mutually compared.

The Athena X-ray Integral Field Unit (X-IFU)

NASA Astrophysics Data System (ADS)

Pajot, F.; Barret, D.; Lam-Trong, T.; den Herder, J.-W.; Piro, L.; Cappi, M.; Huovelin, J.; Kelley, R.; Mas-Hesse, J. M.; Mitsuda, K.; Paltani, S.; Rauw, G.; Rozanska, A.; Wilms, J.; Barbera, M.; Douchin, F.; Geoffray, H.; den Hartog, R.; Kilbourne, C.; Le Du, M.; Macculi, C.; Mesnager, J.-M.; Peille, P.

2018-04-01

The X-ray Integral Field Unit (X-IFU) of the Advanced Telescope for High-ENergy Astrophysics (Athena) large-scale mission of ESA will provide spatially resolved high-resolution X-ray spectroscopy from 0.2 to 12 keV, with 5^' ' } pixels over a field of view of 5 arc minute equivalent diameter and a spectral resolution of 2.5 eV (FWHM) up to 7 keV. The core scientific objectives of Athena drive the main performance parameters of the X-IFU. We present the current reference configuration of the X-IFU, and the key issues driving the design of the instrument.

REFERENCE MANUAL FOR RASSMIT VERSION 2.1: SUB-SLAB DEPRESSURIZATION SYSTEM DESIGN PERFORMANCE SIMULATION PROGRAM

EPA Science Inventory

The report is a reference manual for RASSMlT Version 2.1, a computer program that was developed to simulate and aid in the design of sub-slab depressurization systems used for indoor radon mitigation. The program was designed to run on DOS-compatible personal computers to ensure ...

75 FR 29823 - Energy Conservation Program for Consumer Products: Test Procedures for Refrigerators...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-27

...'') sets forth a variety of provisions designed to improve energy efficiency. (All references to EPCA refer... amended under this section shall be reasonably designed to produce test results which measure energy... a cabinet designed for the refrigerated storage of food at temperatures above 32 [deg]F and below 39...

Studies of the System-Environment Interaction by Electron Beam Emission from a Sounding Rocket Payload in the Ionosphere

NASA Astrophysics Data System (ADS)

Myers, Neil Brubaker

The CHARGE-2 sounding rocket payload was designed to measure the transient and steady-state electrical charging of a space vehicle at low-Earth-orbit altitudes during the emission of a low-power electron beam from the vehicle. In addition to the electron gun, the payload contained several diagnostics to monitor plasma and waves resulting from the beam/space/vehicle interaction. The payload was separated into two sections, the larger section carried a 1-keV electron gun and was referred to as the mother vehicle. The smaller section, referred to as the daughter, was connected to the mother by an insulated, conducting tether and was deployed to a distance of up to 426 m across the geomagnetic field. Payload stabilization was obtained using thrusters that released cold nitrogen gas. In addition to performing electron beam experiments, the mother vehicle contained a high-voltage power supply capable of applying up to +450 V and 28 mA to the daughter through the tether. The 1-keV electron beam was generated at beam currents of 1 mA to 48 mA, measured at the exit aperture of the electron gun. Steady-state potentials of up to 560 V were measured for the mother vehicle. The daughter attained potentials of up to 1000 V relative to the background ionosphere and collected currents up to 6.5 mA. Thruster firings increased the current collection to the vehicle firing the thrusters and resulted in neutralization of the payload. The CHARGE-2 experiment was unique in that for the first time a comparison was made of the current collection between an electron beam-emitting vehicle and a non-emitting vehicle at high potential (400 V to 1000 V). The daughter current collection agreed well with the Parker-Murphy model, while the mother current collection always exceeded the Parker-Murphy limit and even exceeded the Langmuir-Blodgett predicted current below 240 km. The additional current collection of the mother is attributed to beam-plasma interaction. This additional source of collected current may be very important for successful electron beam emission at altitudes below 240 km.

GCR Simulator Reference Field and a Spectral Approach for Laboratory Simulation

NASA Technical Reports Server (NTRS)

Slaba, Tony C.; Blattnig, Steve R.; Norbury, John W.; Rusek, Adam; La Tessa, Chiara; Walker, Steven A.

2015-01-01

The galactic cosmic ray (GCR) simulator at the NASA Space Radiation Laboratory (NSRL) is intended to deliver the broad spectrum of particles and energies encountered in deep space to biological targets in a controlled laboratory setting. In this work, certain aspects of simulating the GCR environment in the laboratory are discussed. Reference field specification and beam selection strategies at NSRL are the main focus, but the analysis presented herein may be modified for other facilities. First, comparisons are made between direct simulation of the external, free space GCR field and simulation of the induced tissue field behind shielding. It is found that upper energy constraints at NSRL limit the ability to simulate the external, free space field directly (i.e. shielding placed in the beam line in front of a biological target and exposed to a free space spectrum). Second, variation in the induced tissue field associated with shielding configuration and solar activity is addressed. It is found that the observed variation is likely within the uncertainty associated with representing any GCR reference field with discrete ion beams in the laboratory, given current facility constraints. A single reference field for deep space missions is subsequently identified. Third, an approach for selecting beams at NSRL to simulate the designated reference field is presented. Drawbacks of the proposed methodology are discussed and weighed against alternative simulation strategies. The neutron component and track structure characteristics of the simulated field are discussed in this context.

5 CFR 1631.4 - Public reference facilities and current index.

Code of Federal Regulations, 2010 CFR

2010-01-01

... index. 1631.4 Section 1631.4 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD AVAILABILITY OF RECORDS Production or Disclosure of Records Under the Freedom of Information Act, 5 U.S.C. 552 § 1631.4 Public reference facilities and current index. (a) The Board maintains a public reading area...

Development of integrated programs for Aerospace-vehicle Design (IPAD): Product program management systems

NASA Technical Reports Server (NTRS)

Isenberg, J. M.; Southall, J. W.

1979-01-01

The Integrated Programs for Aerospace Vehicle Design (IPAD) is a computing system to support company-wide design information processing. This document presents a brief description of the management system used to direct and control a product-oriented program. This document, together with the reference design process (CR 2981) and the manufacture interactions with the design process (CR 2982), comprises the reference information that forms the basis for specifying IPAD system requirements.

Design Reference Missions for Deep-Space Optical Communication

NASA Astrophysics Data System (ADS)

Breidenthal, J.; Abraham, D.

2016-05-01

We examined the potential, but uncertain, NASA mission portfolio out to a time horizon of 20 years, to identify mission concepts that potentially could benefit from optical communication, considering their communications needs, the environments in which they would operate, and their notional size, weight, and power constraints. A set of 12 design reference missions was selected to represent the full range of potential missions. These design reference missions span the space of potential customer requirements, and encompass the wide range of applications that an optical ground segment might eventually be called upon to serve. The design reference missions encompass a range of orbit types, terminal sizes, and positions in the solar system that reveal the chief system performance variables of an optical ground segment, and may be used to enable assessments of the ability of alternative systems to meet various types of customer needs.

A Cognitive Game Theoretic Analysis of Conflict Alerts in Air Traffic Control

NASA Technical Reports Server (NTRS)

Erev, Ido; Gopher, Daniel; Remington, Roger

1999-01-01

The current research was motivated by the recommendation made by a joint Government/Industry committee to introduce a new traffic control system, referred to as the Free Flight. This system is designed to use recent new technology to facilitate efficient and safe air transportation. We addressed one of the major difficulties that arise in the design of this and similar multi-agent systems: the adaptive (and slippery) nature of human agents. To facilitate a safe and efficient design of this multi-agent system, designers have to rely on assessments of the expected behavior of the different agents under various scenarios. Whereas the behavior of the computerized agents is predictable, the behavior of the human agents (including air traffic controllers and pilots) is not. Experimental and empirical observations suggest that human agents are likely to adjust their behavior to the design of the system. To see the difficulty that the adaptive nature of human agents creates assume that a good approximation of the way operators currently behave is available. Given this information an optimal design can be performed. The problem arises as the human operator will learn to adjust their behavior to the new system. Following this adjustment process the assumptions made by the designer concerning the operators behavior will no longer be accurate and the system might reach a suboptimal state. In extreme situations these potential suboptimal states might involve unnecessary risk. That is, the fact that operators learn in an adaptive fashion does not imply that the system will become safer as they gain experience. At least in the context of Safety dilemmas, experience can lead to a pareto deficient risk taking behavior.

Analysis and Down Select of Flow Passages for Thermal Hydraulic Testing of a SNAP Derived Reactor

NASA Technical Reports Server (NTRS)

Godfroy, T. J.; Sadasivan, P.; Masterson, S.

2007-01-01

As past of the Vision for Space Exploration, man will return to the moon. To enable safe and productive time on the lunar surface will require adequate power resources. To provide the needed power and to give mission planners all landing site possibilities, including a permanently dark crater, a nuclear reactor provides the most options. Designed to be l00kWt providing approx. 25kWe this power plants would be very effective in delivering dependable, site non-specific power to crews or robotic missions on the lunar surface. An affordable reference reactor based upon the successful SNAP program of the 1960's and early 1970's has been designed by Los Alamos National Laboratory that will meet such a requirement. Considering current funding, environmental, and schedule limitations this lunar surface power reactor will be tested using non-nuclear simulators to simulate the heat from fission reactions. Currently a 25kWe surface power SNAP derivative reactor is in the early process of design and testing with collaboration between Los Alamos National Laboratory, Idaho National Laboratory, Glenn Research Center, Marshall Space Flight Center, and Sandia National Laboratory to ensure that this new design is affordable and can be tested using non-nuclear methods as have proven so effective in the past. This paper will discuss the study and down selection of a flow passage concept for a approx. 25kWe lunar surface power reactor. Several different flow passages designs were evaluated using computational fluid dynamics to determine pressure drop and a structural assessment to consider thermal and stress of the passage walls. The reactor design basis conditions are discussed followed by passage problem setup and results for each concept. A recommendation for passage design is made with rationale for selection.

Preliminary Axial Flow Turbine Design and Off-Design Performance Analysis Methods for Rotary Wing Aircraft Engines. Part 1; Validation

NASA Technical Reports Server (NTRS)

Chen, Shu-cheng, S.

2009-01-01

For the preliminary design and the off-design performance analysis of axial flow turbines, a pair of intermediate level-of-fidelity computer codes, TD2-2 (design; reference 1) and AXOD (off-design; reference 2), are being evaluated for use in turbine design and performance prediction of the modern high performance aircraft engines. TD2-2 employs a streamline curvature method for design, while AXOD approaches the flow analysis with an equal radius-height domain decomposition strategy. Both methods resolve only the flows in the annulus region while modeling the impact introduced by the blade rows. The mathematical formulations and derivations involved in both methods are documented in references 3, 4 for TD2-2) and in reference 5 (for AXOD). The focus of this paper is to discuss the fundamental issues of applicability and compatibility of the two codes as a pair of companion pieces, to perform preliminary design and off-design analysis for modern aircraft engine turbines. Two validation cases for the design and the off-design prediction using TD2-2 and AXOD conducted on two existing high efficiency turbines, developed and tested in the NASA/GE Energy Efficient Engine (GE-E3) Program, the High Pressure Turbine (HPT; two stages, air cooled) and the Low Pressure Turbine (LPT; five stages, un-cooled), are provided in support of the analysis and discussion presented in this paper.

Putting the Horse Back in Front of the Cart: Using Visions and Decisions about High-Quality Learning Experiences to Drive Course Design

ERIC Educational Resources Information Center

Allen, Deborah; Tanner, Kimberly

2007-01-01

This article discusses a systematic approach to designing significant learning experiences, often referred to as the "backward design process," which has been popularized by Wiggins and McTighe (1998) and is included as a central feature of L. Dee Fink's model for integrated course design (Fink, 2003). The process is referred to as backward…

Accelerating Cogent Confabulation: An Exploration in the Architecture Design Space

DTIC Science & Technology

2008-06-01

DATES COVERED (From - To) 1-8 June 2008 4. TITLE AND SUBTITLE ACCELERATING COGENT CONFABULATION: AN EXPLORATION IN THE ARCHITECTURE DESIGN SPACE 5a...spiking neural networks is proposed in reference [8]. Reference [9] investigates the architecture design of a Brain-state-in-a-box model. The...Richard Linderman2, Thomas Renz2, Qing Wu1 Accelerating Cogent Confabulation: an Exploration in the Architecture Design Space POSTPRINT complexity

Meteoroids and Orbital Debris: Effects on Spacecraft

NASA Technical Reports Server (NTRS)

Belk, Cynthia A.; Robinson, Jennifer H.; Alexander, Margaret B.; Cooke, William J.; Pavelitz, Steven D.

1997-01-01

The natural space environment is characterized by many complex and subtle phenomena hostile to spacecraft. The effects of these phenomena impact spacecraft design, development, and operations. Space systems become increasingly susceptible to the space environment as use of composite materials and smaller, faster electronics increases. This trend makes an understanding of the natural space environment essential to accomplish overall mission objectives, especially in the current climate of better/cheaper/faster. Meteoroids are naturally occurring phenomena in the natural space environment. Orbital debris is manmade space litter accumulated in Earth orbit from the exploration of space. Descriptions are presented of orbital debris source, distribution, size, lifetime, and mitigation measures. This primer is one in a series of NASA Reference Publications currently being developed by the Electromagnetics and Aerospace Environments Branch, Systems Analysis and Integration Laboratory, Marshall Space Flight Center, National Aeronautics and Space Administration.

Five-year examination of utilization and drug cost outcomes associated with benefit design changes including reference pricing for proton pump inhibitors in a state employee health plan.

PubMed

Johnson, Jill T; Neill, Kathryn K; Davis, Dwight A

2011-04-01

The Arkansas State Employee Benefits Division (EBD) is a self-insured program comprising public school and other state employees, their spouses, and dependents. Previous research published in JMCP (2006) showed drug cost savings of $2.20 per member per month (PMPM; 37.6%) or annualized savings of $3.4 million associated with a benefit design change and coverage of the proton pump inhibitor (PPI) omeprazole over-the-counter (OTC) beginning in March 2004. On May 1, 2005, brand esomeprazole was excluded from coverage, with current users grandfathered for 4 months until September 2005. Reference pricing for PPIs, including esomeprazole but excluding generic omeprazole, was implemented on September 1, 2005, and the beneficiary cost share for all PPIs except generic omeprazole was determined from comparison of the PPI actual price to the $0.90 omeprazole OTC reference price per unit. To examine PPI utilization and drug costs before and after (a) excluding esomeprazole from coverage (with grandfathering current users) and (b) implementing a therapeutic maximum allowable cost (TMAC), or reference-pricing benefit design, for the PPI class in a large state employee health plan with fairly stable enrollment of approximately 127,500 members in 2005 through 2008 and approximately 128,000 members in 2009 Q1. The pharmacy claims database for the EBD was used to examine utilization and cost data for PPIs in a longitudinal analysis for the 61-month period from March 1, 2004, through March 31, 2009. Pharmacy claims data were compared for the period 14 months prior to esomeprazole exclusion (preperiod), 4 months during the esomeprazole exclusion (postperiod 1), and the ensuing 43 months of PPI reference pricing (postperiod 2). PPI cost and utilization data for the intervention group of approximately 127,500 beneficiaries were compared with a group of 122 self-insured employers with a total of nearly 1 million beneficiaries whose pharmacy benefits did not include reference pricing for PPIs. Despite 79% of existing esomeprazole users being grandfathered during the 4-month esomeprazole-exclusion period (postperiod 1), the share of omeprazole OTC claims increased from 35.2% to 42.5% (+ 7.3 percentage points) of all PPI claims, and esomeprazole claims decreased from 16.7% to 12.0% (-4.7 percentage points), with little change in the use of other PPIs. The average allowed charge (price) per day of PPI drug therapy decreased in postperiod 1 by 8.9% from $2.81 to $2.56, while utilization increased by 2.2% from 1.83 days PMPM to 1.87 days PMPM; the net plan cost PMPM decreased by $0.40 PMPM from $3.78 to $3.38 (-10.6%), representing a reduction in spending of $35,664 per month while the average member copayment per claim was essentially unchanged. In the 43 months of reference pricing in postperiod 2, PPI utilization was essentially unchanged at 1.82 days PMPM compared with the preperiod (1.83 days PMPM) and 2.7% lower than the esomeprazole-exclusion period (1.87 days PMPM); however, price (charge per day) decreased by 38.4% during refer- RESEARCH ence pricing to $1.73 from $2.81 in the preperiod and by 32.4% compared with $2.56 in the esomeprazole-exclusion period, despite an increase in the average pharmacy dispensing fee to $5.21 per PPI claim. Net plan cost decreased by $1.87 PMPM (49.5%) to $1.91 PMPM during reference pricing compared with the preperiod ($3.78 PMPM) and by $1.47 PMPM (43.5%) compared with the esomeprazole-exclusion period 1 ($3.38 PMPM). Beneficiary costs (copayment per claim) for PPIs decreased to $1.24 PMPM ($23.27 per claim) compared with the preperiod ($1.37 PMPM, $24.95 per claim) and compared with the esomeprazole-exclusion period ($1.40 PMPM, $25.06 per claim). The reductions in net plan costs represented lower plan spending for the 43 months of reference pricing (postperiod 2) of approximately $9.4 million or an average of approximately $219,500 per month compared with the preperiod or $7.9 million (approximately $183,900 per month) compared with the esomeprazole-exclusion period. Compared with a group of self-insured health plans without pharmacy benefit reference pricing of PPIs, the cost savings over the 43-month period from September 1, 2005, through March 31, 2009, were approximately $7.2 million or $1.31 PMPM. For this state employee health plan, the policy change that excluded esomeprazole from coverage but grandfathered current users was associated with a relatively small reduction in PMPM spending on PPIs compared with the subsequent policy change that applied reference pricing to the PPI class based on the price (drug cost plus dispensing fee) for omeprazole OTC. Over 43 months of reference pricing, net plan costs fell dramatically by 49.5% PMPM compared with the preperiod or decreased by 43.5% compared with the esomeprazole-exclusion period. While utilization was essentially unchanged compared with the 18 months before reference pricing, the average pharmacy dispensing fee per PPI claim increased, and beneficiary costs PMPM decreased.

Review of current sonic boom studies.

NASA Technical Reports Server (NTRS)

Kane, E. J.

1973-01-01

Several aspects of the sonic boom phenomena are currently under investigation at The Boeing Co. This work, supported by the NASA and the FAA, includes an in-depth analysis of sonic boom measurements recorded at the BREN tower, a summary and evaluation of sonic boom investigations done in the last decade and a half, and configuration studies to determine practical lower bound sonic boom limits. The BREN tower test program yielded unique and valuable data because it was the first time that vertical profile measurements were made through caustics produced by maneuvers and atmospheric refraction. The objective of the second effort is to compile in a single reference an annotated abstract, including significant results, for each published sonic boom study and to provide a comprehensive review of the current state of the art to aid future researchers. The configuration work is devoted toward determining the feasibility of supersonic transport type airplanes with a primary design goal of acceptable sonic boom characteristics. Each of these investigations is briefly reviewed and significant results are discussed.

Micro acoustic spectrum analyzer

DOEpatents

Schubert, W. Kent; Butler, Michael A.; Adkins, Douglas R.; Anderson, Larry F.

2004-11-23

A micro acoustic spectrum analyzer for determining the frequency components of a fluctuating sound signal comprises a microphone to pick up the fluctuating sound signal and produce an alternating current electrical signal; at least one microfabricated resonator, each resonator having a different resonant frequency, that vibrate in response to the alternating current electrical signal; and at least one detector to detect the vibration of the microfabricated resonators. The micro acoustic spectrum analyzer can further comprise a mixer to mix a reference signal with the alternating current electrical signal from the microphone to shift the frequency spectrum to a frequency range that is a better matched to the resonant frequencies of the microfabricated resonators. The micro acoustic spectrum analyzer can be designed specifically for portability, size, cost, accuracy, speed, power requirements, and use in a harsh environment. The micro acoustic spectrum analyzer is particularly suited for applications where size, accessibility, and power requirements are limited, such as the monitoring of industrial equipment and processes, detection of security intrusions, or evaluation of military threats.

Magnetic bearings for free-piston Stirling engines

NASA Technical Reports Server (NTRS)

Curwen, P. W.; Flemig, D. P.; Rao, D. K.; Wilson, D. S.

1992-01-01

The feasibility and efficiency of applying magnetic bearings to free-piston Stirling-cycle power conversion machinery currently being developed for long-term space missions are assessed. The study was performed for a 50-kWe Reference Stirling Space Power Converter (RSSPC) which currently uses hydrostatic gas bearings to support the reciprocating displacer and power piston assemblies. Active magnetic bearings of the attractive electromagnetic type are feasible for the RSSPC power piston. Magnetic support of the displacer assembly would require unacceptable changes to the design of the current RSSPC. However, magnetic suspension of both displacer and power piston is feasible for a relative-displacer version of the RSSPC. Magnetic suspension of the RSSPC power piston can potentially increase overall efficiency by 0.5 to 1 percent (0.1 to 0.3 efficieny points). Magnetic bearings will also overcome several operational concerns associated with hydrostatic gas bearing systems. These advantages, however, are accompanied by a 5 percent increase in specific mass of the RSSPC.

Magnetic bearings for free-piston Stirling engines

NASA Technical Reports Server (NTRS)

Curwen, P. W.; Fleming, D. P.; Rao, D. K.; Wilson, D. S.

1992-01-01

The feasibility and efficacy of applying magnetic bearings to free-piston Stirling-cycle power conversion machinery currently being developed for long-term space missions are assessed. The study was performed for a 50-kWe Reference Stirling Space Power Converter (RSSPC) which currently uses hydrostatic gas bearings to support the reciprocating displacer and power piston assemblies. Active magnetic bearings of the attractive electromagnetic type are feasible for the RSSPC power piston. Magnetic support of the displacer assembly would require unacceptable changes to the design of the current RSSPC. However, magnetic suspension of both displacer and power piston is feasible for a relative-displacer version of the RSSPC. Magnetic suspension of the RSSPC power piston can potentially increase overall efficiency by 0.5 to 1 percent (0.1 to 0.3 efficiency points). Magnetic bearings will also overcome several operational concerns associated with hydrostatic gas bearing systems. These advantages, however, are accompanied by a 5 percent increase in specific mass of the RSSPC.

High-Sensitivity Fast Neutron Detector KNK-2-8M

NASA Astrophysics Data System (ADS)

Koshelev, A. S.; Dovbysh, L. Ye.; Ovchinnikov, M. A.; Pikulina, G. N.; Drozdov, Yu. M.; Chuklyaev, S. V.; Pepyolyshev, Yu. N.

2017-12-01

The design of the fast neutron detector KNK-2-8M is outlined. The results of he detector study in the pulse counting mode with pulses from 238U nuclei fission in the radiator of the neutron-sensitive section and in the current mode with separation of functional section currents are presented. The possibilities of determination of the effective number of 238U nuclei in the radiator of the neutron-sensitive section are considered. The diagnostic capabilities of the detector in the counting mode are demonstrated, as exemplified by the analysis of reference data on characteristics of neutron fields in the BR-1 reactor hall. The diagnostic capabilities of the detector in the current mode are demonstrated, as exemplified by the results of measurements of 238U fission intensity in the power startup of the BR-K1 reactor in the fission pulse generation mode with delayed neutrons and the detector placed in the reactor cavity in conditions of large-scale variation of the reactor radiation fields.

Modeling Canadian Quality Control Test Program for Steroid Hormone Receptors in Breast Cancer: Diagnostic Accuracy Study.

PubMed

Pérez, Teresa; Makrestsov, Nikita; Garatt, John; Torlakovic, Emina; Gilks, C Blake; Mallett, Susan

The Canadian Immunohistochemistry Quality Control program monitors clinical laboratory performance for estrogen receptor and progesterone receptor tests used in breast cancer treatment management in Canada. Current methods assess sensitivity and specificity at each time point, compared with a reference standard. We investigate alternative performance analysis methods to enhance the quality assessment. We used 3 methods of analysis: meta-analysis of sensitivity and specificity of each laboratory across all time points; sensitivity and specificity at each time point for each laboratory; and fitting models for repeated measurements to examine differences between laboratories adjusted by test and time point. Results show 88 laboratories participated in quality control at up to 13 time points using typically 37 to 54 histology samples. In meta-analysis across all time points no laboratories have sensitivity or specificity below 80%. Current methods, presenting sensitivity and specificity separately for each run, result in wide 95% confidence intervals, typically spanning 15% to 30%. Models of a single diagnostic outcome demonstrated that 82% to 100% of laboratories had no difference to reference standard for estrogen receptor and 75% to 100% for progesterone receptor, with the exception of 1 progesterone receptor run. Laboratories with significant differences to reference standard identified with Generalized Estimating Equation modeling also have reduced performance by meta-analysis across all time points. The Canadian Immunohistochemistry Quality Control program has a good design, and with this modeling approach has sufficient precision to measure performance at each time point and allow laboratories with a significantly lower performance to be targeted for advice.

Share2Quit: Web-Based Peer-Driven Referrals for Smoking Cessation

PubMed Central

2013-01-01

Background Smoking is the number one preventable cause of death in the United States. Effective Web-assisted tobacco interventions are often underutilized and require new and innovative engagement approaches. Web-based peer-driven chain referrals successfully used outside health care have the potential for increasing the reach of Internet interventions. Objective The objective of our study was to describe the protocol for the development and testing of proactive Web-based chain-referral tools for increasing the access to Decide2Quit.org, a Web-assisted tobacco intervention system. Methods We will build and refine proactive chain-referral tools, including email and Facebook referrals. In addition, we will implement respondent-driven sampling (RDS), a controlled chain-referral sampling technique designed to remove inherent biases in chain referrals and obtain a representative sample. We will begin our chain referrals with an initial recruitment of former and current smokers as seeds (initial participants) who will be trained to refer current smokers from their social network using the developed tools. In turn, these newly referred smokers will also be provided the tools to refer other smokers from their social networks. We will model predictors of referral success using sample weights from the RDS to estimate the success of the system in the targeted population. Results This protocol describes the evaluation of proactive Web-based chain-referral tools, which can be used in tobacco interventions to increase the access to hard-to-reach populations, for promoting smoking cessation. Conclusions Share2Quit represents an innovative advancement by capitalizing on naturally occurring technology trends to recruit smokers to Web-assisted tobacco interventions. PMID:24067329

Scaffolding Students' Development of Creative Design Skills: A Curriculum Reference Model

ERIC Educational Resources Information Center

Lee, Chien-Sing; Kolodner, Janet L.

2011-01-01

This paper provides a framework for promoting creative design capabilities in the context of achieving community goals pertaining to sustainable development among high school students. The framework can be used as a reference model to design formal or out-of-school curriculum units in any geographical region. This theme is chosen due to its…

Floristry. Instructor Guide [and] Student Reference. Volume 28, Number 1 [and] Volume 28, Number 2.

ERIC Educational Resources Information Center

Rothenberger, Barbara; And Others

This instructor guide and the corresponding student reference contain 7 units that include 30 lessons for a course in floristry. The lessons topics are as follows: the floristry industry, plant identification, post-harvest handling, the mechanics of floral design, basic principles of floral design, construction of various types of designs, and…

Reference Structures: Stagnation, Progress, and Future Challenges.

ERIC Educational Resources Information Center

Greenberg, Jane

1997-01-01

Assesses the current state of reference structures in online public access catalogs (OPACs) in a framework defined by stagnation, progress, and future challenges. Outlines six areas for reference structure development. Twenty figures provide illustrations. (AEF)

The Librarian as Information Consultant: Transforming Reference for the Information Age

ERIC Educational Resources Information Center

Murphy, Sarah Anne

2011-01-01

Library users' evolving information needs and their choice of search methods have changed reference work profoundly. Today's reference librarian must work in a whole new way--not only service-focused and businesslike, but even entrepreneurial. Murphy innovatively rethinks the philosophy behind current library reference services in this…

Intra-coil interactions in split gradient coils in a hybrid MRI-LINAC system.

PubMed

Tang, Fangfang; Freschi, Fabio; Sanchez Lopez, Hector; Repetto, Maurizio; Liu, Feng; Crozier, Stuart

2016-04-01

An MRI-LINAC system combines a magnetic resonance imaging (MRI) system with a medical linear accelerator (LINAC) to provide image-guided radiotherapy for targeting tumors in real-time. In an MRI-LINAC system, a set of split gradient coils is employed to produce orthogonal gradient fields for spatial signal encoding. Owing to this unconventional gradient configuration, eddy currents induced by switching gradient coils on and off may be of particular concern. It is expected that strong intra-coil interactions in the set will be present due to the constrained return paths, leading to potential degradation of the gradient field linearity and image distortion. In this study, a series of gradient coils with different track widths have been designed and analyzed to investigate the electromagnetic interactions between coils in a split gradient set. A driving current, with frequencies from 100 Hz to 10 kHz, was applied to study the inductive coupling effects with respect to conductor geometry and operating frequency. It was found that the eddy currents induced in the un-energized coils (hereby-referred to as passive coils) positively correlated with track width and frequency. The magnetic field induced by the eddy currents in the passive coils with wide tracks was several times larger than that induced by eddy currents in the cold shield of cryostat. The power loss in the passive coils increased with the track width. Therefore, intra-coil interactions should be included in the coil design and analysis process. Copyright © 2016 Elsevier Inc. All rights reserved.

A high sensitivity heterodyne interferometer as a possible optical readout for the LISA gravitational reference sensor and its application to technology verification

NASA Astrophysics Data System (ADS)

Gohlke, Martin; Schuldt, Thilo; Weise, Dennis; Cordero, Jorge; Peters, Achim; Johann, Ulrich; Braxmaier, Claus

2017-11-01

The gravitational wave detector LISA utilizes as current baseline a high sensitivity Optical Readout (ORO) for measuring the relative position and tilt of a free flying proof mass with respect to the satellite housing. The required sensitivities in the frequency band from 30 μHz to 1Hz are ˜ pm/ √ Hz for the translation√ and nrad/√ Hz for the tilt measurement. EADS Astrium, in collaboration with the Humboldt University Berlin and the University of Applied Sciences Konstanz, has realized a prototype ORO over the past years. The interferometer is based on a highly symmetric design where both, measurement and reference beam have a similar optical pathlength, and the same frequency and polarization. The technique of differential wavefront sensing (DWS) for tilt measurement is implemented. With our setup noise levels below 5pm/ √Hz for translation and below 10nrad/ √Hz for tilt measurements - both for frequencies above 10mHz - were demonstrated. We give an overview over the experimental setup, its current performance and the planned improvements. We also discuss the application to first verification of critical LISA aspects. As example we present measurements of the coefficient of thermal expansion (CTE) of various carbon fiber reinforced plastic (CFRP) including a "near-zero-CTE" tube.

Emerging policy issues in PURPA implementation: an examination of policy issues related to federal and state efforts to encourage development of cogeneration and small power production under Title II of PURPA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Purpose of this study is to examine the results of FERG and state efforts to encourage the development of cogeneration and small power production under Title II of the Public Utility Regualtory Policies Act of 1978 (PURPA) in the years since the statute was enacted. The frame of reference specified by DOE for use in this study includes both the original purposes of the legislation as set forth in PURPA and the current overall energy policy goal which is to ''foster an adequate supply of energy at reasonable costs.'' This review of PURPA implementation efforts is designed to assess themore » results to date in terms of achieving the stated goals of the statute (including ''to encourage cogeneration and small power production''), identify perceived areas of conflict between federal and state efforts to maximize development of qualifying facilities (QFs) and current Administration concerns for achieving greater levels of economic efficiency in electric power supply, briefly examine the nature of such conflicts, with reference to specific cases wherever possible, and suggest possible means of conforming government efforts to encourage QF development with the economic efficiency objectives underlying national energy policy.« less

Coval: Improving Alignment Quality and Variant Calling Accuracy for Next-Generation Sequencing Data

PubMed Central

Kosugi, Shunichi; Natsume, Satoshi; Yoshida, Kentaro; MacLean, Daniel; Cano, Liliana; Kamoun, Sophien; Terauchi, Ryohei

2013-01-01

Accurate identification of DNA polymorphisms using next-generation sequencing technology is challenging because of a high rate of sequencing error and incorrect mapping of reads to reference genomes. Currently available short read aligners and DNA variant callers suffer from these problems. We developed the Coval software to improve the quality of short read alignments. Coval is designed to minimize the incidence of spurious alignment of short reads, by filtering mismatched reads that remained in alignments after local realignment and error correction of mismatched reads. The error correction is executed based on the base quality and allele frequency at the non-reference positions for an individual or pooled sample. We demonstrated the utility of Coval by applying it to simulated genomes and experimentally obtained short-read data of rice, nematode, and mouse. Moreover, we found an unexpectedly large number of incorrectly mapped reads in ‘targeted’ alignments, where the whole genome sequencing reads had been aligned to a local genomic segment, and showed that Coval effectively eliminated such spurious alignments. We conclude that Coval significantly improves the quality of short-read sequence alignments, thereby increasing the calling accuracy of currently available tools for SNP and indel identification. Coval is available at http://sourceforge.net/projects/coval105/. PMID:24116042

Space Nuclear Power and Propulsion: Materials Challenges for the 21st Century

NASA Technical Reports Server (NTRS)

Houts, Mike

2008-01-01

The current focus of NASA s space fission effort is Fission Surface Power (FSP). FSP systems could be used to provide power anytime, anywhere on the surface of the Moon or Mars. FSP systems could be used at locations away from the lunar poles or in permanently shaded regions, with no performance penalty. A potential reference 40 kWe option has been devised that is cost-competitive with alternatives while providing more power for less mass. The potential reference system is readily extensible for use on Mars. At Mars the system could be capable of operating through global dust storms and providing year-round power at any Martian latitude. To ensure affordability, the potential near-term, 40 kWe reference concept is designed to use only well established materials and fuels. However, if various materials challenges could be overcome, extremely high performance fission systems could be devised. These include high power, low mass fission surface power systems; in-space systems with high specific power; and high performance nuclear thermal propulsion systems. This tutorial will provide a brief overview of space fission systems and will focus on materials challenges that, if overcome, could help enable advanced exploration and utilization of the solar system.

Effect of Study Design on Sample Size in Studies Intended to Evaluate Bioequivalence of Inhaled Short‐Acting β‐Agonist Formulations

PubMed Central

Zeng, Yaohui; Singh, Sachinkumar; Wang, Kai

2017-01-01

Abstract Pharmacodynamic studies that use methacholine challenge to assess bioequivalence of generic and innovator albuterol formulations are generally designed per published Food and Drug Administration guidance, with 3 reference doses and 1 test dose (3‐by‐1 design). These studies are challenging and expensive to conduct, typically requiring large sample sizes. We proposed 14 modified study designs as alternatives to the Food and Drug Administration–recommended 3‐by‐1 design, hypothesizing that adding reference and/or test doses would reduce sample size and cost. We used Monte Carlo simulation to estimate sample size. Simulation inputs were selected based on published studies and our own experience with this type of trial. We also estimated effects of these modified study designs on study cost. Most of these altered designs reduced sample size and cost relative to the 3‐by‐1 design, some decreasing cost by more than 40%. The most effective single study dose to add was 180 μg of test formulation, which resulted in an estimated 30% relative cost reduction. Adding a single test dose of 90 μg was less effective, producing only a 13% cost reduction. Adding a lone reference dose of either 180, 270, or 360 μg yielded little benefit (less than 10% cost reduction), whereas adding 720 μg resulted in a 19% cost reduction. Of the 14 study design modifications we evaluated, the most effective was addition of both a 90‐μg test dose and a 720‐μg reference dose (42% cost reduction). Combining a 180‐μg test dose and a 720‐μg reference dose produced an estimated 36% cost reduction. PMID:29281130

Health facilities humanisation: design guidelines supported by statistical evidence.

PubMed

Bosia, Daniela; Marino, Donatella; Peretti, Gabriella

2016-01-01

Healthcare building humanisation is currently a widely debated issue and the development of patient centered and evidence based design is growing worldwide. Many international health organizations and researchers understand the importance of Patient Centred Design and leading architects incorporate it into the design process. In Italy this design approach is still at an early stage. The article refers to research commissioned by the Italian Health Ministry and carried out by R. Del Nord (Università degli Studi di Firenze) and G. Peretti (Politecnico di Torino) with their collaborators. The scope of the research was the definition of design guidelines for healthcare facilities humanisation. The methodology framework adopted is the well established need and performance approach in architectural design. The article deals with the results of statistical investigations for the definition and ranking of users' needs and the consistent expression of their requirements. The investigations were carried out with the cooperation of psychologists of the Università degli Studi di Torino and researchers of the Università degli Studi di Cagliari. The proposed evaluation system allows ranking of health facilities according to the level of humanisation achieved. The statistical investigation evidence collected allowed the definition of humanisation design guidelines for health-care facilities and for the assessment of their specific level of humanisation.

A universal reference sample derived from clone vector for improved detection of differential gene expression

PubMed Central

Khan, Rishi L; Gonye, Gregory E; Gao, Guang; Schwaber, James S

2006-01-01

Background Using microarrays by co-hybridizing two samples labeled with different dyes enables differential gene expression measurements and comparisons across slides while controlling for within-slide variability. Typically one dye produces weaker signal intensities than the other often causing signals to be undetectable. In addition, undetectable spots represent a large problem for two-color microarray designs and most arrays contain at least 40% undetectable spots even when labeled with reference samples such as Stratagene's Universal Reference RNAs™. Results We introduce a novel universal reference sample that produces strong signal for all spots on the array, increasing the average fraction of detectable spots to 97%. Maximizing detectable spots on the reference image channel also decreases the variability of microarray data allowing for reliable detection of smaller differential gene expression changes. The reference sample is derived from sequence contained in the parental EST clone vector pT7T3D-Pac and is called vector RNA (vRNA). We show that vRNA can also be used for quality control of microarray printing and PCR product quality, detection of hybridization anomalies, and simplification of spot finding and segmentation tasks. This reference sample can be made inexpensively in large quantities as a renewable resource that is consistent across experiments. Conclusion Results of this study show that vRNA provides a useful universal reference that yields high signal for almost all spots on a microarray, reduces variation and allows for comparisons between experiments and laboratories. Further, it can be used for quality control of microarray printing and PCR product quality, detection of hybridization anomalies, and simplification of spot finding and segmentation tasks. This type of reference allows for detection of small changes in differential expression while reference designs in general allow for large-scale multivariate experimental designs. vRNA in combination with reference designs enable systems biology microarray experiments of small physiologically relevant changes. PMID:16677381

WFC3/UVIS Dark Calibration: Monitoring Results and Improvements to Dark Reference Files

NASA Astrophysics Data System (ADS)

Bourque, M.; Baggett, S.

2016-04-01

The Wide Field Camera 3 (WFC3) UVIS detector possesses an intrinsic signal during exposures, even in the absence of light, known as dark current. A daily monitor program is employed every HST cycle to characterize and measure this current as well as to create calibration files which serve to subtract the dark current from science data. We summarize the results of the daily monitor program for all on-orbit data. We also introduce a new algorithm for generating the dark reference files that provides several improvements to their overall quality. Key features to the new algorithm include correcting the dark frames for Charge Transfer Efficiency (CTE) losses, using an anneal-cycle average value to measure the dark current, and generating reference files on a daily basis. This new algorithm is part of the release of the CALWF3 v3.3 calibration pipeline on February 23, 2016 (also known as "UVIS 2.0"). Improved dark reference files have been regenerated and re-delivered to the Calibration Reference Data System (CRDS) for all on-orbit data. Observers with science data taken prior to the release of CALWF3 v3.3 may request their data through the Mikulski Archive for Space Telescopes (MAST) to obtain the improved products.

Height of South Asian children in the Netherlands aged 0-20 years: secular trends and comparisons with current Asian Indian, Dutch and WHO references.

PubMed

de Wilde, Jeroen A; van Dommelen, Paula; van Buuren, Stef; Middelkoop, Barend J C

2015-01-01

People from Asian populations are generally shorter than other ethnic groups. It is unknown if current universal height references are suitable for affluent South Asian children in the Netherlands. To develop height-for-age charts for contemporary South Asian children aged 0-20 years living in the Netherlands, to evaluate secular trends, and to compare the charts with current Asian Indian, Dutch and WHO references. A population-based study measured 3315 South Asian children aged 0-20 years between 2007-2010. Among this cohort, 6876 measurements were taken. Another 7388 measurements were taken of a historical cohort of 1078 children born between 1974-1976 (aged 0-18 years). An upward trend in height was observed for South Asian children living in the Netherlands between 1992-2010. The height-for-age charts of the South Asian historical cohort were similar to current Asian Indian charts. South Asian children in the Netherlands were shorter than their Dutch contemporaries at every age; and these differences increased further during adolescence. Compared to the WHO height-for-age references, there were considerable discrepancies in height, with curves intersecting twice. The discrepancies between the South Asian and Dutch and WHO height-for-age references indicate differences in growth patterns between the source populations.

Fiber-Optic Current Sensor Validation with Triggered Lightning Measurements

NASA Technical Reports Server (NTRS)

Nguyen, Truong X.; Ely, Jay J.; Szatkowski, George N.; Mata, Carlos T.; Mata, Angel G.; Snyder, Gary P.

2013-01-01

A fiber optic current sensor based on the Faraday Effect is developed that is highly suitable for aircraft installation and can measure total current enclosed in a fiber loop down to DC. Other attributes include being small, light-weight, non-conducting, safe from electromagnetic interference, and free of hysteresis and saturation. The Faraday Effect causes light polarization to rotate when exposed to a magnetic field in the direction of light propagation. Measuring the induced light polarization rotation in fiber loops yields the total current enclosed. Two sensor systems were constructed and installed at Camp Blanding, Florida, measuring rocket-triggered lightning. The systems were similar in design but with different laser wavelengths, sensitivities and ranges. Results are compared to a shunt resistor as reference. The 850nm wavelength system tested in summer 2011 showed good result comparison early. However, later results showed gradual amplitude increase with time, attributed to corroded connections affecting the 50-ohm output termination. The 1550nm system also yielded good results in the summer 2012. The successful measurements demonstrate the fiber optic sensor's accuracies in capturing real lightning currents, and represent an important step toward future aircraft installation.

Flight Dynamics Analysis Branch End of Fiscal Year 2004 Report

NASA Technical Reports Server (NTRS)

DeLion, Anne (Editor); Stengle, Thomas

2005-01-01

This report summarizes the major activities and accomplishments carried out by the Flight Dynamics Analysis Branch (FDAB), Code 595, in support of flight projects and technology development initiatives in Fiscal Year (FY) 2004. The report is intended to serve as a summary of the type of support carried out by the FDAB, as well as a concise reference of key accomplishments and mission experience derived from the various mission support roles. The primary focus of the FDAB is to provide expertise in the disciplines of flight dynamics including spacecraft navigation (autonomous and ground based); spacecraft trajectory design and maneuver planning; attitude analysis; attitude determination and sensor calibration; and attitude control subsystem (ACS) analysis and design. The FDAB currently provides support for missions and technology development projects involving NASA, other government agencies, academia, and private industry.

Buckling Test Results and Preliminary Test and Analysis Correlation from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA02

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.; Thornburgh, Robert P

2017-01-01

Results from the testing of cylinder test article SBKF-P2-CYL-TA02 (referred to herein as TA02) are presented. TA02 is an 8-foot-diameter (96-inches), 78.0-inch-long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch-vehicle structures and was designed to exhibit global buckling when subjected to combined compression and bending loads. The testing was conducted at the Marshall Space Flight Center (MSFC), February 3-6, 2009, in support of the Shell Buckling Knockdown Factor Project (SBKF). The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF researchers.

Flight Dynamics Analysis Branch End of Fiscal Year 2005 Report

NASA Technical Reports Server (NTRS)

2006-01-01

This report summarizes the major activities and accomplishments carried out by the Flight Dynamics Analysis Branch (FDAB), Code 595, in support of flight projects and technology development initiatives in Fiscal Year (FY) 2005. The report is intended to serve as a summary of the type of support carried out by the FDAB, as well as a concise reference of key accomplishments and mission experience derived from the various mission support roles. The primary focus of the FDAB is to provide expertise in the disciplines of flight dynamics including spacecraft navigation (autonomous and ground based), spacecraft trajectory design and maneuver planning, attitude analysis, attitude determination and sensor calibration, and attitude control subsystem (ACS) analysis and design. The FDAB currently provides support for missions and technology development projects involving NASA, other government agencies, academia, and private industry.

Development of a Reference Information Model and Knowledgebase for Electronic Bloodstream Infection Detection

PubMed Central

Borlawsky, Tara; Hota, Bala; Lin, Michael Y.; Khan, Yosef; Young, Jeremy; Santangelo, Jennifer; Stevenson, Kurt B.

2008-01-01

The most prevalent hospital-acquired infections in the United States are bloodstream infections (BSIs) associated with the presence of a central venous catheter. There is currently a movement, including national organizations such as the Centers for Medicare and Medicaid Services as well as consumer, quality improvement and patient safety groups, encouraging the standardization of reporting and aggregation of such nosocomial infection data to increase and improve reporting, and enable rate comparisons among healthcare institutions. Domain modeling is a well-known method for designing interoperable processes that take advantage of existing data and legacy systems. We have combined such a model-driven design approach with the use of partitioned clinical and business logic knowledgebases in order to employ a previously validated electronic BSI surveillance algorithm in the context of a multi-center study. PMID:18999213

An Overview of a Trajectory-Based Solution for En Route and Terminal Area Self-Spacing: Seventh Revision

NASA Technical Reports Server (NTRS)

Abbott, Terence S.

2015-01-01

This paper presents an overview of the seventh revision to an algorithm specifically designed to support NASA's Airborne Precision Spacing concept. This paper supersedes the previous documentation and presents a modification to the algorithm referred to as the Airborne Spacing for Terminal Arrival Routes version 13 (ASTAR13). This airborne self-spacing concept contains both trajectory-based and state-based mechanisms for calculating the speeds required to achieve or maintain a precise spacing interval. The trajectory-based capability allows for spacing operations prior to the aircraft being on a common path. This algorithm was also designed specifically to support a standalone, non-integrated implementation in the spacing aircraft. This current revision to the algorithm adds the state-based capability in support of evolving industry standards relating to airborne self-spacing.

An Overview of a Trajectory-Based Solution for En Route and Terminal Area Self-Spacing: Eighth Revision

NASA Technical Reports Server (NTRS)

Abbott, Terence S.; Swieringa, Kurt S.

2017-01-01

This paper presents an overview of the eighth revision to an algorithm specifically designed to support NASA's Airborne Precision Spacing concept. This paper supersedes the previous documentation and presents a modification to the algorithm referred to as the Airborne Spacing for Terminal Arrival Routes version 13 (ASTAR13). This airborne self-spacing concept contains both trajectory-based and state-based mechanisms for calculating the speeds required to achieve or maintain a precise spacing interval with another aircraft. The trajectory-based capability allows for spacing operations prior to the aircraft being on a common path. This algorithm was also designed specifically to support a standalone, non-integrated implementation in the spacing aircraft. This current revision to the algorithm supports the evolving industry standards relating to airborne self-spacing.

Inductance analyzer based on auto-balanced circuit for precision measurement of fluxgate impedance

NASA Astrophysics Data System (ADS)

Setiadi, Rahmondia N.; Schilling, Meinhard

2018-05-01

An instrument for fluxgate sensor impedance measurement based on an auto-balanced circuit has been designed and characterized. The circuit design is adjusted to comply with the fluxgate sensor characteristics which are low impedance and highly saturable core with very high permeability. The system utilizes a NI-DAQ card and LabVIEW to process the signal acquisition and evaluation. Some fixed reference resistances are employed for system calibration using linear regression. A multimeter HP 34401A and impedance analyzer Agilent 4294A are used as calibrator and validator for the resistance and inductance measurements. Here, we realized a fluxgate analyzer instrument based on auto-balanced circuit, which measures the resistance and inductance of the device under test with a small error and much lower excitation current to avoid core saturation compared to the used calibrator.

Tube-like natural halloysite/poly(tetrafluoroethylene) nanocomposites: simultaneous enhancement in thermal and mechanical properties

NASA Astrophysics Data System (ADS)

Gamini, Suresh; Vasu, V.; Bose, Suryasarathi

2017-04-01

In the current study, PTFE (polytetrafluroethylene) matrix is reinforced with different wt% (2%-10%) of Halloysite nanotubes (HNTs). PTFE samples are fabricated with 2 wt% increment and are designated from ‘B’to ‘F’ and designation ‘A’ refers to neat PTFE. Thermal and mechanical characterization of the fabricated composites is studied. The calorimetric measurements showed enhanced degree of crystallinity of the nanocomposites, which is from 57.83% to 74.7%. The dynamic mechanical analysis results have shown enhanced storage modulus and loss modulus and reduced damping behaviour, without affecting glass transition temperature. Moreover, significant improvements in mechanical properties are observed from the experimental results. The results are discussed and validated with the existing literature. The phase and the fracture morphology of the nanocomposites is studied using scanning electron microscope and discussed herein.

Compensated count-rate circuit for radiation survey meter

DOEpatents

Todd, Richard A.

1981-01-01

A count-rate compensating circuit is provided which may be used in a portable Geiger-Mueller (G-M) survey meter to ideally compensate for counting loss errors in the G-M tube detector. In a G-M survey meter, wherein the pulse rate from the G-M tube is converted into a pulse rate current applied to a current meter calibrated to indicate dose rate, the compensated circuit generates and controls a reference voltage in response to the rate of pulses from the detector. This reference voltage is gated to the current-generating circuit at a rate identical to the rate of pulses coming from the detector so that the current flowing through the meter is varied in accordance with both the frequency and amplitude of the reference voltage pulses applied thereto so that the count rate is compensated ideally to indicate a true count rate within 1% up to a 50% duty cycle for the detector. A positive feedback circuit is used to control the reference voltage so that the meter output tracks true count rate indicative of the radiation dose rate.

Compensated count-rate circuit for radiation survey meter

DOEpatents

Todd, R.A.

1980-05-12

A count-rate compensating circuit is provided which may be used in a portable Geiger-Mueller (G-M) survey meter to ideally compensate for couting loss errors in the G-M tube detector. In a G-M survey meter, wherein the pulse rate from the G-M tube is converted into a pulse rate current applied to a current meter calibrated to indicate dose rate, the compensation circuit generates and controls a reference voltage in response to the rate of pulses from the detector. This reference voltage is gated to the current-generating circuit at a rate identical to the rate of pulses coming from the detector so that the current flowing through the meter is varied in accordance with both the frequency and amplitude of the reference voltage pulses applied thereto so that the count rate is compensated ideally to indicate a true count rate within 1% up to a 50% duty cycle for the detector. A positive feedback circuit is used to control the reference voltage so that the meter output tracks true count rate indicative of the radiation dose rate.

Updated Mars Mission Architectures Featuring Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Rodriguez, Mitchell A.; Percy, Thomas K.

2017-01-01

Nuclear thermal propulsion (NTP) can potentially enable routine human exploration of Mars and the solar system. By using nuclear fission instead of a chemical combustion process, and using hydrogen as the propellant, NTP systems promise rocket efficiencies roughly twice that of the best chemical rocket engines currently available. The most recent major Mars architecture study featuring NTP was the Design Reference Architecture 5.0 (DRA 5.0), performed in 2009. Currently, the predominant transportation options being considered are solar electric propulsion (SEP) and chemical propulsion; however, given NTP's capabilities, an updated architectural analysis is needed. This paper provides a top-level overview of several different architectures featuring updated NTP performance data. New architectures presented include a proposed update to the DRA 5.0 as well as an investigation of architectures based on the current Evolvable Mars Campaign, which is the focus of NASA's current analyses for the Journey to Mars. Architectures investigated leverage the latest information relating to NTP performance and design considerations and address new support elements not available at the time of DRA 5.0, most notably the Orion crew module and the Space Launch System (SLS). The paper provides a top level quantitative comparison of key performance metrics as well as a qualitative discussion of improvements and key challenges still to be addressed. Preliminary results indicate that the updated NTP architectures can significantly reduce the campaign mass and subsequently the costs for assembly and number of launches.

Dynamic Range and Sensitivity Requirements of Satellite Ocean Color Sensors: Learning from the Past

NASA Technical Reports Server (NTRS)

Hu, Chuanmin; Feng, Lian; Lee, Zhongping; Davis, Curtiss O.; Mannino, Antonio; McClain, Charles R.; Franz, Bryan A.

2012-01-01

Sensor design and mission planning for satellite ocean color measurements requires careful consideration of the signal dynamic range and sensitivity (specifically here signal-to-noise ratio or SNR) so that small changes of ocean properties (e.g., surface chlorophyll-a concentrations or Chl) can be quantified while most measurements are not saturated. Past and current sensors used different signal levels, formats, and conventions to specify these critical parameters, making it difficult to make cross-sensor comparisons or to establish standards for future sensor design. The goal of this study is to quantify these parameters under uniform conditions for widely used past and current sensors in order to provide a reference for the design of future ocean color radiometers. Using measurements from the Moderate Resolution Imaging Spectroradiometer onboard the Aqua satellite (MODISA) under various solar zenith angles (SZAs), typical (L(sub typical)) and maximum (L(sub max)) at-sensor radiances from the visible to the shortwave IR were determined. The Ltypical values at an SZA of 45 deg were used as constraints to calculate SNRs of 10 multiband sensors at the same L(sub typical) radiance input and 2 hyperspectral sensors at a similar radiance input. The calculations were based on clear-water scenes with an objective method of selecting pixels with minimal cross-pixel variations to assure target homogeneity. Among the widely used ocean color sensors that have routine global coverage, MODISA ocean bands (1 km) showed 2-4 times higher SNRs than the Sea-viewing Wide Field-of-view Sensor (Sea-WiFS) (1 km) and comparable SNRs to the Medium Resolution Imaging Spectrometer (MERIS)-RR (reduced resolution, 1.2 km), leading to different levels of precision in the retrieved Chl data product. MERIS-FR (full resolution, 300 m) showed SNRs lower than MODISA and MERIS-RR with the gain in spatial resolution. SNRs of all MODISA ocean bands and SeaWiFS bands (except the SeaWiFS near-IR bands) exceeded those from prelaunch sensor specifications after adjusting the input radiance to L(sub typical). The tabulated L(sub typical), L(sub max), and SNRs of the various multiband and hyperspectral sensors under the same or similar radiance input provide references to compare sensor performance in product precision and to help design future missions such as the Geostationary Coastal and Air Pollution Events (GEO-CAPE) mission and the Pre-Aerosol-Clouds-Ecosystems (PACE) mission currently being planned by the U.S. National Aeronautics and Space Administration (NASA).

Interface of Linguistic and Visual Information During Audience Design.

PubMed

Fukumura, Kumiko

2015-08-01

Evidence suggests that speakers can take account of the addressee's needs when referring. However, what representations drive the speaker's audience design has been less clear. This study aims to go beyond previous studies by investigating the interplay between the visual and linguistic context during audience design. Speakers repeated subordinate descriptions (e.g., firefighter) given in the prior linguistic context less and used basic-level descriptions (e.g., man) more when the addressee did not hear the linguistic context than when s/he did. But crucially, this effect happened only when the referent lacked the visual attributes associated with the expressions (e.g., the referent was in plain clothes rather than in a firefighter uniform), so there was no other contextual cue available for the identification of the referent. This suggests that speakers flexibly use different contextual cues to help their addressee map the referring expression onto the intended referent. In addition, speakers used fewer pronouns when the addressee did not hear the linguistic antecedent than when s/he did. This suggests that although speakers may be egocentric during anaphoric reference (Fukumura & Van Gompel, 2012), they can cooperatively avoid pronouns when the linguistic antecedents were not shared with their addressee during initial reference. © 2014 Cognitive Science Society, Inc.

Intra prediction using face continuity in 360-degree video coding

NASA Astrophysics Data System (ADS)

Hanhart, Philippe; He, Yuwen; Ye, Yan

2017-09-01

This paper presents a new reference sample derivation method for intra prediction in 360-degree video coding. Unlike the conventional reference sample derivation method for 2D video coding, which uses the samples located directly above and on the left of the current block, the proposed method considers the spherical nature of 360-degree video when deriving reference samples located outside the current face to which the block belongs, and derives reference samples that are geometric neighbors on the sphere. The proposed reference sample derivation method was implemented in the Joint Exploration Model 3.0 (JEM-3.0) for the cubemap projection format. Simulation results for the all intra configuration show that, when compared with the conventional reference sample derivation method, the proposed method gives, on average, luma BD-rate reduction of 0.3% in terms of the weighted spherical PSNR (WS-PSNR) and spherical PSNR (SPSNR) metrics.

Predictor-Based Model Reference Adaptive Control

NASA Technical Reports Server (NTRS)

Lavretsky, Eugene; Gadient, Ross; Gregory, Irene M.

2009-01-01

This paper is devoted to robust, Predictor-based Model Reference Adaptive Control (PMRAC) design. The proposed adaptive system is compared with the now-classical Model Reference Adaptive Control (MRAC) architecture. Simulation examples are presented. Numerical evidence indicates that the proposed PMRAC tracking architecture has better than MRAC transient characteristics. In this paper, we presented a state-predictor based direct adaptive tracking design methodology for multi-input dynamical systems, with partially known dynamics. Efficiency of the design was demonstrated using short period dynamics of an aircraft. Formal proof of the reported PMRAC benefits constitute future research and will be reported elsewhere.

Space Shuttle Orbiter Drag Chute Summary

NASA Technical Reports Server (NTRS)

Lowry, Charles H.

2013-01-01

This paper summarizes the development history and technical highlights of the Space Shuttle Orbiter Drag Chute Program. Data and references are given on the design, development, and testing of the system, plus several interesting operational issues and solutions. The last Shuttle flight was completed in 2011 and all the Orbiters have now become museum pieces. Before all the data from system development and the 86 Orbiter Drag Chute (ODC) operational landings is lost or forgotten, it may be useful to summarize it here and to identify data sources for future reference. Much has been written about various aspects of the program, and this summary has attempted to cite many such references to make available more detailed information. The ODC program was a high-visibility NASA program that afforded the opportunity to thoroughly engineer and test the chute system, far beyond so many of today s tight-budget programs. So the ODC program was extremely informative--it provided a wide scope of information including protective door jettison issues and solutions, wind tunnel data and analyses on chute stability and drag behind a huge and rather blunt forebody, component and system reuse, and chute cleaning methods. Technology and data created have aided several current and past parachute programs, and will continue to do so in the future. The original Orbiter preliminary design included a drag parachute-- it was deleted early to save weight. But after the 1987 Challenger accident and during the program redefinition phase that followed, Astronaut John Young presented a strong case for enhancing landing safety by adding nosegear steering, brake improvements, and reviving the drag chute.

Mission Report on the Orbiter Camera Payload System (OCPS) Large Format Camera (LFC) and Attitude Reference System (ARS)

NASA Technical Reports Server (NTRS)

Mollberg, Bernard H.; Schardt, Bruton B.

1988-01-01

The Orbiter Camera Payload System (OCPS) is an integrated photographic system which is carried into earth orbit as a payload in the Space Transportation System (STS) Orbiter vehicle's cargo bay. The major component of the OCPS is a Large Format Camera (LFC), a precision wide-angle cartographic instrument that is capable of producing high resolution stereo photography of great geometric fidelity in multiple base-to-height (B/H) ratios. A secondary, supporting system to the LFC is the Attitude Reference System (ARS), which is a dual lens Stellar Camera Array (SCA) and camera support structure. The SCA is a 70-mm film system which is rigidly mounted to the LFC lens support structure and which, through the simultaneous acquisition of two star fields with each earth-viewing LFC frame, makes it possible to determine precisely the pointing of the LFC optical axis with reference to the earth nadir point. Other components complete the current OCPS configuration as a high precision cartographic data acquisition system. The primary design objective for the OCPS was to maximize system performance characteristics while maintaining a high level of reliability compatible with Shuttle launch conditions and the on-orbit environment. The full-up OCPS configuration was launched on a highly successful maiden voyage aboard the STS Orbiter vehicle Challenger on October 5, 1984, as a major payload aboard mission STS 41-G. This report documents the system design, the ground testing, the flight configuration, and an analysis of the results obtained during the Challenger mission STS 41-G.

The Absolute Stability Analysis in Fuzzy Control Systems with Parametric Uncertainties and Reference Inputs

NASA Astrophysics Data System (ADS)

Wu, Bing-Fei; Ma, Li-Shan; Perng, Jau-Woei

This study analyzes the absolute stability in P and PD type fuzzy logic control systems with both certain and uncertain linear plants. Stability analysis includes the reference input, actuator gain and interval plant parameters. For certain linear plants, the stability (i.e. the stable equilibriums of error) in P and PD types is analyzed with the Popov or linearization methods under various reference inputs and actuator gains. The steady state errors of fuzzy control systems are also addressed in the parameter plane. The parametric robust Popov criterion for parametric absolute stability based on Lur'e systems is also applied to the stability analysis of P type fuzzy control systems with uncertain plants. The PD type fuzzy logic controller in our approach is a single-input fuzzy logic controller and is transformed into the P type for analysis. In our work, the absolute stability analysis of fuzzy control systems is given with respect to a non-zero reference input and an uncertain linear plant with the parametric robust Popov criterion unlike previous works. Moreover, a fuzzy current controlled RC circuit is designed with PSPICE models. Both numerical and PSPICE simulations are provided to verify the analytical results. Furthermore, the oscillation mechanism in fuzzy control systems is specified with various equilibrium points of view in the simulation example. Finally, the comparisons are also given to show the effectiveness of the analysis method.

Single-Case Designs and Qualitative Methods: Applying a Mixed Methods Research Perspective

ERIC Educational Resources Information Center

Hitchcock, John H.; Nastasi, Bonnie K.; Summerville, Meredith

2010-01-01

The purpose of this conceptual paper is to describe a design that mixes single-case (sometimes referred to as single-subject) and qualitative methods, hereafter referred to as a single-case mixed methods design (SCD-MM). Minimal attention has been given to the topic of applying qualitative methods to SCD work in the literature. These two…

The dynamics and control of solar-sail spacecraft in displaced lunar orbits

NASA Astrophysics Data System (ADS)

Wawrzyniak, Geoffrey George

Trajectory generation for any spacecraft mission application typically involves either well-developed analytical approximations or a linearization with respect to a known solution. Such approximations are based on the well-understood dynamics of behavior in the system. However, when two or more large bodies (e.g., the Earth and the Moon or the Sun, the Earth and the Moon) are present, trajectories in the multi-body gravitational field can evolve chaotically. The problem is further complicated when an additional force from a solar sail is included. Solar sail trajectories are often developed in a Sun-centered reference frame in which the sunlight direction is fixed. New challenges arise when modeling a solar-sail trajectory in a reference frame attached to the Earth and the Moon (a frame that rotates in inertial space). Advantages accrue from geometry and symmetry properties that are available in this Earth--Moon reference frame, but the Sun location and the sunlight direction change with time. Current trajectory design tools can reveal many solutions within these regimes. Recent work using numerical boundary value problem (BVP) solvers has demonstrated great promise for uncovering additional and, sometimes, "better" solutions to problems in spacecraft trajectory design involving solar sails. One such approach to solving BVPs is the finite-difference method. Derivatives that appear in the differential equations are replaced with their respective finite differences and evaluated at node points along the trajectory. The solution process is iterative. A candidate solution, such as an offset circle or a point, is discretized into nodes, and the equations that represent the relationships at the nodes are solved simultaneously. Finite-difference methods (FDMs) exploit coarse initial approximations and, with the system constraints (such as the continuous visibility of the spacecraft from a point on the lunar surface), to develop orbital solutions in regions where the structure of the solution space is not well known. Because of their simplicity and speed, the FDM is used to populate a survey to assist in the understanding of the available design space. Trajectories generated by FDMs can also be used to initialize other nonlinear BVP solvers. Any solution is only as accurate as the model used to generate it, especially when the trajectory is dynamically unstable, certainly the case when an orbit is purposefully offset from the Moon. Perturbations, such as unmodeled gravitational forces, variations in the solar flux, as well as mis-modeling of the sail and bus properties, all shift the spacecraft off the reference trajectory and, potentially, into a regime from which the vehicle is unrecoverable. Therefore, some type of flight-path control is required to maintain the vehicle near the reference path. Reference trajectories, supplied by FDMs, are used to develop guidance algorithms based on other, more accurate, numerical procedures, such as multiple shooting. The primary motivation of this investigation is to determine what level of technology is required to displace a solar sail spacecraft sufficiently such that a vehicle equipped with a sail supplies a continuous relay between the Earth and an outpost at the lunar south pole. To accomplish this objective, numerical methods to generate reference orbits that meet mission constraints are examined, as well as flight-path control strategies to ensure that a sailcraft follows those reference trajectories. A survey of the design space is also performed to highlight vehicle-performance and ground-based metrics critical to a mission that monitors the lunar south pole at all times. Finally, observations about the underlying dynamical structure of solar sail motion in a multi-body system are summarized.

The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models

PubMed Central

Vernetti, Lawrence; Bergenthal, Luke; Shun, Tong Ying; Taylor, D. Lansing

2016-01-01

Abstract Microfluidic human organ models, microphysiology systems (MPS), are currently being developed as predictive models of drug safety and efficacy in humans. To design and validate MPS as predictive of human safety liabilities requires safety data for a reference set of compounds, combined with in vitro data from the human organ models. To address this need, we have developed an internet database, the MPS database (MPS-Db), as a powerful platform for experimental design, data management, and analysis, and to combine experimental data with reference data, to enable computational modeling. The present study demonstrates the capability of the MPS-Db in early safety testing using a human liver MPS to relate the effects of tolcapone and entacapone in the in vitro model to human in vivo effects. These two compounds were chosen to be evaluated as a representative pair of marketed drugs because they are structurally similar, have the same target, and were found safe or had an acceptable risk in preclinical and clinical trials, yet tolcapone induced unacceptable levels of hepatotoxicity while entacapone was found to be safe. Results demonstrate the utility of the MPS-Db as an essential resource for relating in vitro organ model data to the multiple biochemical, preclinical, and clinical data sources on in vivo drug effects. PMID:28781990

Value-Based Assessment of Radiology Reporting Using Radiologist-Referring Physician Two-Way Feedback System-a Design Thinking-Based Approach.

PubMed

Shaikh, Faiq; Hendrata, Kenneth; Kolowitz, Brian; Awan, Omer; Shrestha, Rasu; Deible, Christopher

2017-06-01

In the era of value-based healthcare, many aspects of medical care are being measured and assessed to improve quality and reduce costs. Radiology adds enormously to health care costs and is under pressure to adopt a more efficient system that incorporates essential metrics to assess its value and impact on outcomes. Most current systems tie radiologists' incentives and evaluations to RVU-based productivity metrics and peer-review-based quality metrics. In a new potential model, a radiologist's performance will have to increasingly depend on a number of parameters that define "value," beginning with peer review metrics that include referrer satisfaction and feedback from radiologists to the referring physician that evaluates the potency and validity of clinical information provided for a given study. These new dimensions of value measurement will directly impact the cascade of further medical management. We share our continued experience with this project that had two components: RESP (Referrer Evaluation System Pilot) and FRACI (Feedback from Radiologist Addressing Confounding Issues), which were introduced to the clinical radiology workflow in order to capture referrer-based and radiologist-based feedback on radiology reporting. We also share our insight into the principles of design thinking as applied in its planning and execution.

Design of an ontology for medical image manipulation: an example applied for DICOM extensions

NASA Astrophysics Data System (ADS)

Aubry, Florent; Chameroy, Virginie; Todd-Pokropek, Andrew; Di Paola, Robert

1999-07-01

Currently, various data formats are widely used for medical imags, e.g. DICOM for exchange through network and storage media, and INTERFILE for image exchange in nuclear medicine. These formats are only able partly to solve problems arising in accessing and handling imags. To solve such problems, an ontology dedicated to the description of data and knowledge involved in the handling and the management of medical images has been designed. The ontology offers a semantic frame of reference to which manipulation tools can refer. It considers various point of view on the data, related to the context of production, the content,and the data quality. It supports several levels of abstraction, going from a declarative level related to the examination type to the implementation level. Moreover, the ontology provides mechanisms allowing the creation and the description of new entities. It can, thus, act as an intermediate language ensuring accurate reuse of the entities. This paper, which presents work in progress, is focused on the description of the ontology and points out how to use it for the description of and the access to DICOM or INTERFILE entities, and for the extension of the DICOM or INTERFILE dictionaries, by adding new entities, in order to describe complex relationships between images.

Compression and fast retrieval of SNP data.

PubMed

Sambo, Francesco; Di Camillo, Barbara; Toffolo, Gianna; Cobelli, Claudio

2014-11-01

The increasing interest in rare genetic variants and epistatic genetic effects on complex phenotypic traits is currently pushing genome-wide association study design towards datasets of increasing size, both in the number of studied subjects and in the number of genotyped single nucleotide polymorphisms (SNPs). This, in turn, is leading to a compelling need for new methods for compression and fast retrieval of SNP data. We present a novel algorithm and file format for compressing and retrieving SNP data, specifically designed for large-scale association studies. Our algorithm is based on two main ideas: (i) compress linkage disequilibrium blocks in terms of differences with a reference SNP and (ii) compress reference SNPs exploiting information on their call rate and minor allele frequency. Tested on two SNP datasets and compared with several state-of-the-art software tools, our compression algorithm is shown to be competitive in terms of compression rate and to outperform all tools in terms of time to load compressed data. Our compression and decompression algorithms are implemented in a C++ library, are released under the GNU General Public License and are freely downloadable from http://www.dei.unipd.it/~sambofra/snpack.html. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Compression and fast retrieval of SNP data

PubMed Central

Sambo, Francesco; Di Camillo, Barbara; Toffolo, Gianna; Cobelli, Claudio

2014-01-01

Motivation: The increasing interest in rare genetic variants and epistatic genetic effects on complex phenotypic traits is currently pushing genome-wide association study design towards datasets of increasing size, both in the number of studied subjects and in the number of genotyped single nucleotide polymorphisms (SNPs). This, in turn, is leading to a compelling need for new methods for compression and fast retrieval of SNP data. Results: We present a novel algorithm and file format for compressing and retrieving SNP data, specifically designed for large-scale association studies. Our algorithm is based on two main ideas: (i) compress linkage disequilibrium blocks in terms of differences with a reference SNP and (ii) compress reference SNPs exploiting information on their call rate and minor allele frequency. Tested on two SNP datasets and compared with several state-of-the-art software tools, our compression algorithm is shown to be competitive in terms of compression rate and to outperform all tools in terms of time to load compressed data. Availability and implementation: Our compression and decompression algorithms are implemented in a C++ library, are released under the GNU General Public License and are freely downloadable from http://www.dei.unipd.it/~sambofra/snpack.html. Contact: sambofra@dei.unipd.it or cobelli@dei.unipd.it. PMID:25064564

Resource management plan for the Oak Ridge Reservation. Volume 30, Oak Ridge National Environmental Research Park natural areas and reference areas--Oak Ridge Reservation environmentally sensitive sites containing special plants, animals, and communities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pounds, L.R.; Parr, P.D.; Ryon, M.G.

1993-08-01

Areas on the Oak Ridge Reservation (ORR) that contain rare plant or animal species or are special habitats are protected through National Environmental Research Park Natural Area (NA) or Reference Area (RA) designations. The US Department of Energy`s Oak Ridge National Environmental Research Park program is responsible for identifying species of vascular plants that are endangered, threatened, or rare and, as much as possible, for conserving those areas in which such species grow. This report includes a listing of Research Park NAs and RAs with general habitat descriptions and a computer-generated map with the areas identified. These are the locationsmore » of rare plant or animal species or special habitats that are known at this time. As the Reservation continues to be surveyed, it is expected that additional sites will be designated as Research Park NAs or RAs. This document is a component of a larger effort to identify environmentally sensitive areas on ORR. This report identifies the currently known locations of rare plant species, rare animal species, and special biological communities. Floodplains, wetlands (except those in RAs or NAs), and cultural resources are not included in this report.« less

Development of Advanced 9Cr Ferritic-Martensitic Steels and Austenitic Stainless Steels for Sodium-Cooled Fast Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sham, Sam; Tan, Lizhen; Yamamoto, Yukinori

2013-01-01

Ferritic-martensitic (FM) steel Grade 92, with or without thermomechanical treatment (TMT), and austenitic stainless steels HT-UPS (high-temperature ultrafine precipitate strengthening) and NF709 were selected as potential candidate structural materials in the U.S. Sodium-cooled Fast Reactor (SFR) program. The objective is to develop advanced steels with improved properties as compared with reference materials such as Grade 91 and Type 316H steels that are currently in nuclear design codes. Composition modification and/or processing optimization (e.g., TMT and cold-work) were performed to improve properties such as resistance to thermal aging, creep, creep-fatigue, fracture, and sodium corrosion. Testings to characterize these properties for themore » advanced steels were conducted by the Idaho National Laboratory, the Argonne National Laboratory and the Oak Ridge National Laboratory under the U.S. SFR program. This paper focuses on the resistance to thermal aging and creep of the advanced steels. The advanced steels exhibited up to two orders of magnitude increase in creep life compared to the reference materials. Preliminary results on the weldment performance of the advanced steels are also presented. The superior performance of the advanced steels would improve reactor design flexibility, safety margins and economics.« less

The development of AR book for computer learning

NASA Astrophysics Data System (ADS)

Phadung, Muneeroh; Wani, Najela; Tongmnee, Nur-aiynee

2017-08-01

Educators need to provide the alternative educational tools to foster learning outcomes of students. By using AR technology to create exciting edutainment experiences, this paper presents how augmented reality (AR) can be applied in the education. This study aims to develop the AR book for tenth grade students (age 15-16) and evaluate its quality. The AR book was developed based on ADDIE framework processes to provide computer learning on software computer knowledge. The content was accorded with the current Thai education curriculum. The AR book had 10 pages in three topics (the first was "Introduction," the second was "System Software" and the third was "Application Software"). Each page contained markers that placed virtual objects (2D animation and video clip). The obtained data were analyzed in terms of average and standard deviation. The validity of multimedia design of the AR book was assessed by three experts in multimedia design. A five-point Likert scale was used and the values were X¯ =4 .84 , S.D. = 1.27 which referred to very high. Moreover, three content experts, who specialize in computer teaching, evaluated the AR book's validity. The values determined by the experts were X¯ =4 .69 , S.D. = 0.29 which referred to very high. Implications for future study and education are discussed.

Possible Overlaps Between Blobs, Grism Apertures, and Dithers

NASA Astrophysics Data System (ADS)

Ryan, R. E.; McCullough, P. R.

2017-06-01

We present a investigation into possible overlaps between the known IR blobs with the grism aperture reference positions and the IR dither patterns. Each aperture was designed to place the science target (e.g. a specific star) on a cosmetically clean area of the IR detector. Similarly, the dither patterns were designed to mitigate cosmetic defects by rarely (or ideally never) placing such targets on known defects. Because blobs accumulate with time, the originally defined apertures and dither patterns may no longer accomplish their goals, it is important to reverify these combinations. We find two potential overlaps between the blob, aperture, and dither combinations, but do not recommend any changes to the current suite of aperture references positions and/or dither patterns for two reasons. First, one of the overlaps occurs with a dither/aperture combination that is seldom used for high-value science operations, but rather more common for wide-field surveys/mosaics. Second, the other overlap is 8.7 pix from a blob that has a fiducial radius of 10 pix, which already represents a very conservative distance. We conclude that a similar analysis should be repeated as new blobs occur, to continue to ensure ideal operations for high-value science targets. The purpose of this report is to document the analysis in order to facilitate its repetition in the future.

Method and apparatus for correcting eddy current signal voltage for temperature effects

DOEpatents

Kustra, Thomas A.; Caffarel, Alfred J.

1990-01-01

An apparatus and method for measuring physical characteristics of an electrically conductive material by the use of eddy-current techniques and compensating measurement errors caused by changes in temperature includes a switching arrangement connected between primary and reference coils of an eddy-current probe which allows the probe to be selectively connected between an eddy current output oscilloscope and a digital ohm-meter for measuring the resistances of the primary and reference coils substantially at the time of eddy current measurement. In this way, changes in resistance due to temperature effects can be completely taken into account in determining the true error in the eddy current measurement. The true error can consequently be converted into an equivalent eddy current measurement correction.

Large space telescope, phase A. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1972-01-01

The Phase A study of the Large Space Telescope (LST) is reported. The study defines an LST concept based on the broad mission guidelines provided by the Office of Space Science (OSS), the scientific requirements developed by OSS with the scientific community, and an understanding of long range NASA planning current at the time the study was performed. The LST is an unmanned astronomical observatory facility, consisting of an optical telescope assembly (OTA), scientific instrument package (SIP), and a support systems module (SSM). The report consists of five volumes. The report describes the constraints and trade off analyses that were performed to arrive at a reference design for each system and for the overall LST configuration. A low cost design approach was followed in the Phase A study. This resulted in the use of standard spacecraft hardware, the provision for maintenance at the black box level, growth potential in systems designs, and the sharing of shuttle maintenance flights with other payloads.

Design and Characterization of a Photometer-Colorimeter Standard

NASA Astrophysics Data System (ADS)

Eppeldauer, George P.; Rácz, Miklós

2004-05-01

A photometer and tristimulus colorimeter has been developed at the National Institute of Standards and Technology (NIST) to realize a color scale. A novel construction was developed to implement the spectral-responsivity-based scale with small uncertainty. The new device can be used as a reference illuminance and luminance meter as well. Temperature-controlled filter combinations, with 5-8 layers in one package, are used to match the responsivity of a silicon tunnel-trap detector to the CIE color-matching functions with small spectral mismatch values (f1'). Design considerations to extend the tunnel-trap detector with replaceable single and double apertures and changeable filter combinations are described. The design and fabrication of the filter packages and the dependence of the f1' values on the thickness of the filter layers are discussed. The colorimeter was characterized for angular, spatial, and spectral responsivity. An improved preamplifier can convert current to voltage in an 11-decade dynamic range with 0.01% uncertainty.

Design and characterization of a photometer-colorimeter standard.

PubMed

Eppeldauer, George P; Rácz, Miklós

2004-05-01

A photometer and tristimulus colorimeter has been developed at the National Institute of Standards and Technology (NIST) to realize a color scale. A novel construction was developed to implement the spectral-responsivity-based scale with small uncertainty. The new device can be used as a reference illuminance and luminance meter as well. Temperature-controlled filter combinations, with 5-8 layers in one package, are used to match the responsivity of a silicon tunnel-trap detector to the CIE color-matching functions with small spectral mismatch values (f1'). Design considerations to extend the tunnel-trap detector with replaceable single and double apertures and changeable filter combinations are described. The design and fabrication of the filter packages and the dependence of the f1' values on the thickness of the filter layers are discussed. The colorimeter was characterized for angular, spatial, and spectral responsivity. An improved preamplifier can convert current to voltage in an 11-decade dynamic range with 0.01% uncertainty.

Design and performance of a vacuum-bottle solid-state calorimeter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bracken, D.S.; Biddle, R.; Cech, R.

1997-11-01

EG and G Mound Applied Technologies calorimetry personnel have developed a small, thermos-bottle solid-state calorimeter, which is now undergoing performance testing at Los Alamos National Laboratory. The thermos-bottle solid-state calorimeter is an evaluation prototype for characterizing the heat output of small heat standards and other homogeneous heat sources. The current maximum sample size is 3.5 in. long with a diameter of 0.8 in. The overall size of the thermos bottle and thermoelectric cooling device is 9.25 in. high by 3.75 in. diameter and less than 3 lb. Coupling this unit with compact electronics and a laptop computer makes this calorimetermore » easily hand carried by a single individual. This compactness was achieved by servo controlling the reference temperature below room temperature and replacing the water bath used in conventional calorimeter design with the thermos-bottle insulator. Other design features will also be discussed. The performance of the calorimeter will be presented.« less