Handbook of Adolescent Literacy Research

ERIC Educational Resources Information Center

Christenbury, Leila, Ed.; Bomer, Randy, Ed.; Smagorinsky, Peter, Ed.

2009-01-01

The first comprehensive research handbook of its kind, this volume showcases innovative approaches to understanding adolescent literacy learning in a variety of settings. Distinguished contributors examine how well adolescents are served by current instructional practices and highlight ways to translate research findings more effectively into…

Pharmacotherapy and Pregnancy: Highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy

PubMed Central

Haas, David M.; Hebert, Mary F.; Soldin, Offie P.; Flockhart, David A.; Madadi, Parvaz; Nocon, James J.; Chambers, Christina D.; Hankins, Gary D.; Clark, Shannon; Wisner, Katherine L.; Li, Lang; Renbarger, Jamie L.; Learman, Lee A.

2009-01-01

Abstract To address provider struggles to provide evidence‐based, rational drug therapy to pregnant women, a second conference was convened to highlight the current research in the field. Speakers from academic centers and institutions spoke about: the unique physiology and pathology of pregnancy; pharmacokinetic changes in pregnancy; thyroid disorders in pregnancy; pharmacogenetics in pregnancy; the role of CYP2D6 in pregnancy; treating addiction in pregnancy; the power of teratology networks to inform clinical decisions; the use of anti‐depressants in pregnancy; and how to utilize computer‐based modeling to aid with individualized pharmacotherapy in pregnancy. The Conference highlighted several areas of collaboration with the current Obstetrics Pharmacology Research Units Network (OPRU) and hoped to stimulate further collaboration and knowledge in the area with the common goal to improve the ability to safely and effectively use individualized pharmacotherapy in pregnancy. PMID:20443937

Ethical Considerations in Human Movement Research.

ERIC Educational Resources Information Center

Olivier, Steve

1995-01-01

Highlights ethical issues for human subject research, identifying principles that form the construct of a code of research ethics and evaluating against this construct past human experimentation and current research in human movement studies. The efficacy of legislation and self-regulation is examined. Particular attention is given to the context…

Structural dynamics division research and technology accomplishments for FY 1992 and plans for FY 1993

NASA Technical Reports Server (NTRS)

Wynne, Eleanor C.

1993-01-01

The purpose of this paper is to present the Structural Dynamics Division's research accomplishments for F.Y. 1992 and research plans for F.Y. 1993. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5-year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

Loads and aeroelasticity division research and technology accomplishments for FY 1987 and plans for FY 1988

NASA Technical Reports Server (NTRS)

Dixon, S. C.; Gardner, James E.

1988-01-01

The purpose of this paper is to present the Loads and Aeroelasticity Division's research accomplishments for FY87 and research plans for FY88. The work under each Branch (technical area) is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to five year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendell, Mark J.

This report briefly summarizes, based on recent review articles and selected more recent research reports, current scientific knowledge on two topics: assessing unhealthy levels of indoor D/M in homes and remediating home dampness-related problems to protect health. Based on a comparison of current scientific knowledge to that required to support effective, evidence-based, health-protective policies on home D/M, gaps in knowledge are highlighted, prior questions and research questions specified, and necessary research activities and approaches recommended.

Overview of the Applied Aerodynamics Division

NASA Technical Reports Server (NTRS)

1991-01-01

A major reorganization of the Aeronautics Directorate of the Langley Research Center occurred in early 1989. As a result of this reorganization, the scope of research in the Applied Aeronautics Division is now quite different than that in the past. An overview of the current organization, mission, and facilities of this division is presented. A summary of current research programs and sample highlights of recent research are also presented. This is intended to provide a general view of the scope and capabilities of the division.

The Potential of ESO for Asteroseismology

NASA Astrophysics Data System (ADS)

Aerts, Conny

2017-08-01

The research field of asteroseismology is currently undergoing its first revolution. We start with a brief history of how this field of stellar physics evolved from dream to reality, including ESO's role in it. Subsequently, we highlight how asteroseismology can serve various topics in astrophysics and focus on the current status. We discuss recent findings on the rotation and chemical mixing inside stars. Finally, we look at the perspectives of the second and third revolution in this area and highlight how ESO can play an optimal role in it.

Female arsonists: key features, psychopathologies, and treatment needs.

PubMed

Gannon, Theresa A

2010-01-01

Female-perpetrated arson is a topic that has received relatively little research attention from either psychiatrists or psychologists. In this review, available research regarding the characteristics, psychopathologies, and current treatment efforts with female arsonists is reviewed. Evaluation of current research with female arsonists suggests that very few researchers have compared female arsonists either to suitable female offender control groups or male arsons. Consequently, clinical knowledge and practice regarding female-perpetrated arson is underdeveloped relative to both other areas of forensic-clinical psychiatry and to knowledge of male arsonists. Suggestions are made for translating current research into arson interventions with female arsonists. Core arenas for future treatment and research provision are also highlighted.

Survivorship conference highlights research for survivor care

Cancer.gov

More than 400 leading experts in cancer survivorship convened today for a conference, Cancer Survivorship Research: Translating Science to Care, to focus on such current concerns as how obesity might not have the same effects on all cancer survivors, and

Collaboratives for Wildlife-Wind Turbine Interaction Research: Fostering Multistakeholder Involvement (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinclair, K.

This poster highlights the various wildlife-wind collaboratives (specific to wildlife-wind turbine interaction research) that currently exist. Examples of collaboratives are included along with contact information, objectives, benefits, and ways to advance the knowledge base.

Developing the skills required for evidence-based practice.

PubMed

French, B

1998-01-01

The current health care environment requires practitioners with the skills to find and apply the best currently available evidence for effective health care, to contribute to the development of evidence-based practice protocols, and to evaluate the impact of utilizing validated research findings in practice. Current approaches to teaching research are based mainly on gaining skills by participation in the research process. Emphasis on the requirement for rigour in the process of creating new knowledge is assumed to lead to skill in the process of using research information created by others. This article reflects upon the requirements for evidence-based practice, and the degree to which current approaches to teaching research prepare practitioners who are able to find, evaluate and best use currently available research information. The potential for using the principles of systematic review as a teaching and learning strategy for research is explored, and some of the possible strengths and weakness of this approach are highlighted.

The Fraser Experimental Forest, Colorado: Research program and published research 1937-1985

Treesearch

Robert R. Alexander; Charles A. Troendle; Merrill R. Kaufmann; Wayne D. Shepperd; Glenn L. Crouch; Ross K. Watkins

1985-01-01

This report provides an overview of the research done on the Fraser Experimental Forest. It replaces GTR's no. 40 and 40A by Robert R. Alexander and Ross K. Watkins in 1977. Included are descriptions of physical features and resources, highlights of past and current research, and the publications derived from that research.

Etiology and sequelae of root resorption.

PubMed

Vlaskalic, V; Boyd, R L; Baumrind, S

1998-06-01

This article reviews the current status of investigation into apical root resorption within the context of orthodontic treatment. Treatment and patient factors that have traditionally been investigated are discussed, along with the results of current research in this area. The need for rethinking traditional research strategies in the quest for identifying both control and causative mechanisms is explored. Finally, proposals for key areas of future interest are highlighted.

Mixed-methods research in nursing - a critical review.

PubMed

Bressan, Valentina; Bagnasco, Annamaria; Aleo, Giuseppe; Timmins, Fiona; Barisone, Michela; Bianchi, Monica; Pellegrini, Ramona; Sasso, Loredana

2017-10-01

To review the use of mixed-methods research in nursing with a particular focus on the extent to which current practice informs nurse researchers. It also aimed to highlight gaps in current knowledge, understanding and reporting of this type of research. Mixed-methods research is becoming increasingly popular among nurses and healthcare professionals. Emergent findings from this type of research are very useful for nurses in practice. The combination of both quantitative and qualitative methods provides a scientific base for practice but also richness from the qualitative enquiry. However, at the same time mixed-methods research is underdeveloped. This study identified mixed-methods research papers and critically evaluated their usefulness for research practice. To support the analysis, we performed a two-stage search using CINAHL to find papers with titles that included the key term 'mixed method'. An analysis of studies that used mixed-methods research revealed some inconsistencies in application and reporting. Attempts to use two distinct research methods in these studies often meant that one or both aspects had limitations. Overall methods were applied in a less rigorous way. This has implications for providing somewhat limited direction for novice researchers. There is also potential for application of evidence in healthcare practice that limited validity. This study highlights current gaps in knowledge, understanding and reporting of mixed-methods research. While these methods are useful to gain insight into clinical problems nurses lack guidance with this type of research. This study revealed that the guidance provided by current mixed-methods research is inconsistent and incomplete and this compounds the lack of available direction. There is an urgent need to develop robust guidelines for using mixed-methods research so that findings may be critically implemented in practice. © 2016 John Wiley & Sons Ltd.

Recent highlights of experimental research for inhibiting tumor growth by using Chinese medicine.

PubMed

He, Xi-ran; Han, Shu-yan; Li, Ping-ping

2015-10-01

To give an overview of contemporary experimental research using Chinese medicine (CM) for the treatment of cancer. As an integral part of mainstream medicine in the People's Republic of China, CM emphasizes improvements in holistic physical condition instead of merely killing tumor cells, which is consistent with the current medical model that advocates patient-oriented treatment. Great progress has been made in experimental research, and the principle aspects include anti-tumor angiogenesis, inducing apoptosis and differentiation, reversing multidrug resistance, and improving immune function. As a current hot topic in cancer research, tumor microenvironment (TME) highlights the mutual and interdependent interaction between tumor cells and their surrounding tissues, and the CM treatment concept bears a striking resemblance to it. To date, primary points of TME include extracellular matrix remodeling, inflammation, hypoxia, and angiogenesis, but trials using CM with a focus on TME are rare. Despite considerable recent development, experimental research on CM for solving cancer issues appears insufficient. Greater efforts in this field are urgently needed.

Current Cognitive Distortion Theory and Research: An Internalist Approach to Cognition

ERIC Educational Resources Information Center

Gannon, Theresa A.

2009-01-01

This review examines contemporary cognitive distortion theory and research relating to sexual offenders. In particular, this review highlights that researchers--to date--have tended to adopt an internalist approach to sexual offenders' cognition which views offence-supportive cognitive activity as occurring solely within the mind. This review…

Highlights in emergency medicine medical education research: 2008.

PubMed

Farrell, Susan E; Coates, Wendy C; Khun, Gloria J; Fisher, Jonathan; Shayne, Philip; Lin, Michelle

2009-12-01

The purpose of this article is to highlight medical education research studies published in 2008 that were methodologically superior and whose outcomes were pertinent to teaching and education in emergency medicine. Through a PubMed search of the English language literature in 2008, 30 medical education research studies were independently identified as hypothesis-testing investigations and measurements of educational interventions. Six reviewers independently rated and scored all articles based on eight anchors, four of which related to methodologic criteria. Articles were ranked according to their total rating score. A ranking agreement among the reviewers of 83% was established a priori as a minimum for highlighting articles in this review. Five medical education research studies met the a priori criteria for inclusion and are reviewed and summarized here. Four of these employed experimental or quasi-experimental methodology. Although technology was not a component of the structured literature search employed to identify the candidate articles for this review, 14 of the articles identified, including four of the five highlighted articles, employed or studied technology as a focus of the educational research. Overall, 36% of the reviewed studies were supported by funding; three of the highlighted articles were funded studies. This review highlights quality medical education research studies published in 2008, with outcomes of relevance to teaching and education in emergency medicine. It focuses on research methodology, notes current trends in the use of technology for learning in emergency medicine, and suggests future avenues for continued rigorous study in education.

Difference, Diversity, and Distinctiveness in Education and Learning. Review of Research in Education

ERIC Educational Resources Information Center

Parker, Laurence, Ed.

2007-01-01

Turning the question of "what works" in education on its head, this book, which is a volume of "Review of Research in Education," digs into recent salient research that examines learning contexts within critical literacy, scientific literacy, and teacher education. Highlighting the importance of leveraging current research to explore ways in which…

A Research Agenda on Assessing and Remediating Home Dampness and Mold to Reduce Dampness-Related Health Effects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendell, Mark J.

2015-06-01

This report briefly summarizes, based on recent review articles and selected more recent research reports, current scientific knowledge on two topics: assessing unhealthy levels of indoor D/M in homes and remediating home dampness-related problems to protect health. Based on a comparison of current scientific knowledge to that required to support effective, evidence-based, health-protective policies on home D/M, gaps in knowledge are highlighted, prior questions and research questions specified, and necessary research activities and approaches recommended.

UTM Weather Presentation

NASA Technical Reports Server (NTRS)

Chan, William N.; Kopardekar, Parimal H.; Carmichael, Bruce; Cornman, Larry

2017-01-01

Presentation highlighting how weather affected UAS operations during the UTM field tests. Research to develop UAS weather translation models with a description of current and future work for UTM weather.

EPA's Green Roof Research

EPA Science Inventory

This is a presentation on the basics of green roof technology. The presentation highlights some of the recent ORD research projects on green roofs and provices insight for the end user as to the benefits for green roof technology. It provides links to currently available EPA re...

Creativity Research: Implications for Teaching, Learning and Thinking.

ERIC Educational Resources Information Center

Petrowski, Mary Jane

2000-01-01

Explores reasons why creativity has only recently gained credibility as a legitimate research field and provides an overview of various disciplinary approaches and methodologies currently in use that are relevant to teaching and learning. Highlights include psychometrics; contextual approaches; experimental approaches; biographical, or…

Disciplinarity and Methodology in Intersectionality Theory and Research

ERIC Educational Resources Information Center

Syed, Moin

2010-01-01

Comments on the original article, "Intersectionality and research in psychology," by E. R. Cole. Cole's article, says the current author, makes a welcome and valuable contribution to the field of psychology. Particularly useful are the three questions that she posed, highlighting how these questions are relevant and pressing for all researchers,…

Collective Genius: Bridging the Gaps among Research, Innovation and Practice

ERIC Educational Resources Information Center

O'Hair, Mary John

2011-01-01

In this article, the author focuses on bridging the gaps among research, innovation, and practice. First, the author reflects on historical perspectives involving the use of research to improve education and serve the public good. Second, the author explores the current climate as reflected by three national reports highlighting future roles of…

By the Numbers: Current Research in the Literature

ERIC Educational Resources Information Center

Lindsay, Elizabeth Blakesley, Ed.

2008-01-01

This article highlights various literature covering a broad range of topics that are of interest to public services librarians, from collections and user services to one's own research and professional development. Although addressing many topics, these authors have all used or advocate for solid research methods and data analysis in their works,…

A Research Agenda for Online Teacher Professional Development

ERIC Educational Resources Information Center

Dede, Chris; Ketelhut, Diane Jass; Whitehouse, Pamela; Breit, Lisa; McCloskey, Erin M.

2009-01-01

This article highlights key online teacher professional development (oTPD) areas in need of research based on a review of current oTPD research conducted in conjunction with an oTPD conference held at Harvard University in fall 2005. The literature review of this field documents much work that is anecdotal, describing professional development…

Research to Develop Information Service Aids and Programs for Handicapped Individuals.

ERIC Educational Resources Information Center

Cylke, Frank Kurt; And Others

1980-01-01

Highlights current research relating to the provision of information to disabled persons, including electromechanical technology, tactile technology, and transfer devices and tools for the hearing impaired. A directory identifies pertinent organizations, information dissemination points, and publications. Six references are cited. (FM)

Affect: How Important Is It?

ERIC Educational Resources Information Center

Higbee, Jeanne L.; Dwinell, Patricia L.

1995-01-01

Reviews the current literature to determine the extent to which affect influences the achievement levels of students. Highlights research findings in mathematics, reading, writing, and instructional strategies. Suggests that although affect may be a significant factor in determining the academic success of developmental freshmen, more research is…

General Education: Learning from the Past, Preparing for the Future

ERIC Educational Resources Information Center

Gersten, Karen S.

2012-01-01

This article explores the widening gap between business and societal needs and current general education curricula. Research is presented that documents gaps between projected needs of industry and current practices in postsecondary education, especially in the general education areas. Positive efforts to close the gap are highlighted. Changing…

The Current and Future Role of Business Schools

ERIC Educational Resources Information Center

Rayment, John; Smith, Jonathan

2013-01-01

Purpose: Considerable debate since the global financial crisis has been evident concerning the role of business schools. This article aims to outline the authors' research on their role. Design/methodology/approach: The paper begins with an overview of the significant literature highlighting the current debates impacting on business schools and…

Teacher Performance Appraisal in Thailand: Poison or Panacea?

ERIC Educational Resources Information Center

Pimpa, Nattavud

2005-01-01

This research focuses on the examination of problems related to the national teacher performance appraisal system by the Thai Ministry of Education. It highlights major problems of the current performance appraisal system by delineating the weaknesses and pitfalls of the current appraisal system. The findings indicate problems to three major…

Rethinking Giftedness and Talent in Sport

ERIC Educational Resources Information Center

Tranckle, Peter; Cushion, Christopher J.

2006-01-01

The purpose of this paper is to understand how gifts are discovered and talents developed within sport. The current literature is critically discussed, highlighting contributions and gaps in current knowledge. Due to issues concerning terminology and the nature versus nurture debate, research on talent faces challenges relating to continuity and…

Handbook of Early Literacy Research. Volume 2

ERIC Educational Resources Information Center

Dickinson, David K., Ed.; Neuman, Susan B., Ed.

2006-01-01

Current research increasingly highlights the role of early literacy in young children's development--and informs practices and policies that promote success among diverse learners. This handbook presents cutting-edge knowledge on all aspects of literacy learning in the early years. Volume 2 provides additional perspectives on important topics…

EMSL Quarterly Highlights Report Second Quarter, Fiscal Year 2010 (January 1, 2010 through March 31, 2010)

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, Staci A.; Showalter, Mary Ann; Manke, Kristin L.

2010-04-20

The Environmental Molecular Sciences Laboratory (EMSL) is a U.S. Department of Energy (DOE) national scientific user facility located at Pacific Northwest National Laboratory (PNNL) in Richland, Washington. EMSL is operated by PNNL for the DOE-Office of Biological and Environmental Research. At one location, EMSL offers a comprehensive array of leading-edge resources and expertise. Access to the instrumentation and expertise is obtained on a peer-reviewed proposal basis. Staff members work with researchers to expedite access to these capabilities. The "EMSL Quarterly Highlights Report" documents current research and activities of EMSL staff and users.

State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.

PubMed

Xi, Dan; Bao, Ting; Chen, Qi; Chen, Sushing; Cheng, Yung-Chi; Cullen, Joseph; Frank, David A; Friedberg, Jonathan W; Kronish, Ian; Lee, Jeffrey E; Levine, Mark; Li, Pingping; Li, Shao; Lu, Weidong; Mao, Jun J; O'Keefe, Stephen; Rubinstein, Larry; Shah, Manish A; Standish, Leanna; Paller, Channing J; Chu, Edward

2017-11-01

In May 2016, the Office of Cancer Complementary and Alternative Medicine, Division of Cancer Diagnosis and Treatment, of the National Cancer Institute convened a special workshop focused on the State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research. The current state of the science, gaps, and future opportunities were reviewed and discussed by a distinguished panel of experts in this field of research, and the highlights of this meeting are reported herein. Published by Oxford University Press 2017. This work is written by US Government employees and is in the public domain in the US.

The Future of Teaching Research in the Social Sciences

ERIC Educational Resources Information Center

Wagner, C.

2009-01-01

Current literature on teaching research methodology in the social sciences highlights the changing nature of our world in terms of its complexity and diversity, and points to how this affects the way in which we search for answers to related problems (Brew 2003, 3; Tashakkori and Teddlie 2003, 74). New ways of approaching research problems that…

Prevalence, Diagnosis, Treatment and Research on Autism Spectrum Disorders (ASD) in Singapore and Malaysia

ERIC Educational Resources Information Center

Neik, Tina Ting Xiang; Lee, Lay Wah; Low, Hui Min; Chia, Noel Kok Hwee; Chua, Arnold Chee Keong

2014-01-01

The prevalence of autism is increasing globally. While most of the published works are done in the Western and European countries, the trend in autism research is shifting towards the Asian continent recently. In this review, we aimed to highlight the current prevalence, diagnosis, treatment and research on Autism Spectrum Disorders (ASD) in…

The Strength of the Relation between Performance-Approach and Performance-Avoidance Goal Orientations: Theoretical, Methodological, and Instructional Implications

ERIC Educational Resources Information Center

Linnenbrink-Garcia, Lisa; Middleton, Michael J.; Ciani, Keith D.; Easter, Matthew A.; O'Keefe, Paul A.; Zusho, Akane

2012-01-01

In current research on achievement goal theory, most researchers differentiate between performance-approach and performance-avoidance goal orientations. Evidence from prior research and from several previously published data sets is used to highlight that the correlation is often rather large, with a number of studies reporting correlations above…

Research on School Bullying and Victimization: What Have We Learned and Where Do We Go from Here?

ERIC Educational Resources Information Center

Espelage, Dorothy L.; Swearer, Susan M.

2003-01-01

This special issue on bullying and victimization in "School Psychology Review" highlights current research efforts in American schools on bullying and peer victimization, and how this research can inform prevention and intervention planning. This introductory article provides a brief overview of several major insights gained over the last decade…

Viewing the Future of University Research Libraries through the Perspectives of Scenarios

ERIC Educational Resources Information Center

Cawthorne, Jon Edward

2013-01-01

This research highlights the scenarios that might serve as a strategic vision to describe a future beyond the current library, one which both guides provosts and creates a map for the transformation of human resources and technology in the university research libraries. The scenarios offer managerial leaders an opportunity to envision new roles…

This Month in AJP.

PubMed

2018-05-17

The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

This Month in AJP.

PubMed

2018-06-18

The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

This Month in AJP.

PubMed

2018-06-01

The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

This Month in AJP.

PubMed

2018-05-01

The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Portraits of Fathers. Contemporary Family Trends.

ERIC Educational Resources Information Center

Dubeau, Diane

Noting that a substantial research literature on fathers has been built over the last 20 years and that fathers can no longer be considered "the forgotten parent" of the scientific community, this paper summarizes key research on fathers while highlighting concerns regarding the current emphasis on fatherhood expressed by parents and…

Top Ten Trends in Enrollment Management. Synopsis: Higher Education Research Highlights.

ERIC Educational Resources Information Center

Wolff, Tracy L.; Bryant, Peter S.

This national survey of college and university enrollment management practices examines how current technology is being used to make enrollment management more efficient and cost-effective. The report finds that more enrollment managers use advanced tracking, research, and analysis systems to determine the most effective outreach methods; they…

Integrating Data-Based Decision Making, Assessment for Learning and Diagnostic Testing in Formative Assessment

ERIC Educational Resources Information Center

Van der Kleij, Fabienne M.; Vermeulen, Jorine A.; Schildkamp, Kim; Eggen, Theo J. H .M.

2015-01-01

Recent research has highlighted the lack of a uniform definition of formative assessment, although its effectiveness is widely acknowledged. This paper addresses the theoretical differences and similarities amongst three approaches to formative assessment that are currently most frequently discussed in educational research literature: data-based…

Morphological Awareness Intervention in School-Age Children with Language and Literacy Deficits: A Case Study

ERIC Educational Resources Information Center

Wolter, Julie A.; Green, Laura

2013-01-01

This article highlights the clinical application of morphological awareness intervention to facilitate phonological, vocabulary, reading, and spelling success in children with language and literacy deficits. First, the research-based benefits of morphological awareness instruction are reviewed and current theoretical and research-based…

Reflections on the Research to Practice Gap.

ERIC Educational Resources Information Center

Gersten, Russell; Smith-Jones, Joyce

2001-01-01

This article highlights major points of each of the articles in this special issue on the research to practice gap in special education. It then considers some broader implications, especially the need to foster and establish collegial networks to counter the isolation in which many teachers currently work. (Contains references.) (DB)

Research Perspectives and Best Practices in Educational Technology Integration

ERIC Educational Resources Information Center

Keengwe, Jared

2013-01-01

With advancements in technology continuing to influence all areas of society, students in current classrooms have a different understanding and perspective of learning than the educational system has been designed to teach. Research Perspectives and Best Practices in Educational Technology Integration highlights the emerging digital age, its…

Parent-Adolescent Collaboration: An Interpersonal Model for Understanding Optimal Interactions

ERIC Educational Resources Information Center

Beveridge, Ryan M.; Berg, Cynthia A.

2007-01-01

Current parent-adolescent behavioral interaction research highlights the importance of three elements of behavior in defining adaptive interactions: autonomy, control, and warmth vs. hostility. However, this research has largely addressed the developmental needs and psychosocial outcomes of adolescents, as opposed to parents, with a focus on how…

Biogeochemical research priorities for sustainable biofuel and bioenergy feedstock production in the Americas

USDA-ARS?s Scientific Manuscript database

Rapid expansion in biomass production for biofuels and bioenergy in the Americas is increasing demands on the ecosystem resources required to sustain soil and site productivity. We review the current state of knowledge and highlight gaps in research on biogeochemical processes and ecosystem sustaina...

Capacity Building for School Development: Current Problems and Future Challenges

ERIC Educational Resources Information Center

Ho, Dora; Lee, Moosung

2016-01-01

This article offers a theoretical discussion on the current problems and future challenges of school capacity building in early childhood education (ECE), aiming to highlight some key areas for future research. In recent years, there has been a notable policy shift from monitoring quality through inspection to improving quality through school…

Turbomachinery CFD on parallel computers

NASA Technical Reports Server (NTRS)

Blech, Richard A.; Milner, Edward J.; Quealy, Angela; Townsend, Scott E.

1992-01-01

The role of multistage turbomachinery simulation in the development of propulsion system models is discussed. Particularly, the need for simulations with higher fidelity and faster turnaround time is highlighted. It is shown how such fast simulations can be used in engineering-oriented environments. The use of parallel processing to achieve the required turnaround times is discussed. Current work by several researchers in this area is summarized. Parallel turbomachinery CFD research at the NASA Lewis Research Center is then highlighted. These efforts are focused on implementing the average-passage turbomachinery model on MIMD, distributed memory parallel computers. Performance results are given for inviscid, single blade row and viscous, multistage applications on several parallel computers, including networked workstations.

Oral Biofluid Biomarker Research: Current Status and Emerging Frontiers

PubMed Central

Wang, Austin; Wang, Chris P.; Tu, Michael; Wong, David T.W.

2016-01-01

Salivary diagnostics is a rapidly advancing field that offers clinicians and patients the potential of rapid, noninvasive diagnostics with excellent accuracy. In order for the complete realization of the potential of saliva, however, extensive profiling of constituents must be conducted and diagnostic biomarkers must be thoroughly validated. This article briefly overviews the process of conducting a study of salivary biomarkers in a patient cohort and highlights the studies that have been conducted on different classes of molecules in the saliva. Emerging frontiers in salivary diagnostics research that may significantly advance the field will also be highlighted. PMID:27999326

Kidney disease and obesity: epidemiology, mechanisms and treatment.

PubMed

Câmara, Niels Olsen Saraiva; Iseki, Kunitoshi; Kramer, Holly; Liu, Zhi-Hong; Sharma, Kumar

2017-03-01

The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed.

Test Anxiety, Computer-Adaptive Testing and the Common Core

ERIC Educational Resources Information Center

Colwell, Nicole Makas

2013-01-01

This paper highlights the current findings and issues regarding the role of computer-adaptive testing in test anxiety. The computer-adaptive test (CAT) proposed by one of the Common Core consortia brings these issues to the forefront. Research has long indicated that test anxiety impairs student performance. More recent research indicates that…

Digitisation of Local Heritage: Local Studies Collections and Digitisation in Public Libraries

ERIC Educational Resources Information Center

Smith, Lucy; Rowley, Jennifer

2012-01-01

This study explores the application of digitisation in the context of public library local studies services. Since there has been limited previous research on digitisation and local studies collections, this research makes an important contribution in profiling the current situation, and highlighting the extent to which progress is limited in the…

Religiosity, the Headscarf, and Education in Turkey: An Analysis of 1988 Data and Current Implications

ERIC Educational Resources Information Center

Rankin, Bruce H.; Aytac, Isik A.

2008-01-01

Previous research highlights the continuing relevance of family culture in explaining educational inequalities in Turkey, especially patriarchal beliefs and practices that discourage investment in the education of girls. We extend that research by introducing two much-debated, but empirically untested, aspects of family culture--parental…

Reports of planetary astronomy - 1991

NASA Technical Reports Server (NTRS)

Rahe, Jurgen (Editor)

1993-01-01

This publication provides information about currently funded scientific research projects conducted in the Planetary Astronomy Program during 1991, and consists of two main sections. The first section gives a summary of research objectives, past accomplishments, and projected future investigations, as submitted by each principal investigator. In the second section, recent scientifically significant accomplishments within the Program are highlighted.

RNA as an Enzyme.

ERIC Educational Resources Information Center

Cech, Thomas R.

1986-01-01

Reviews current findings that explain RNA's function as an enzyme in addition to being an informational molecule. Highlights recent research efforts and notes changes in the information base on RNA activity. Includes models and diagrams of RNA activity. (ML)

Current Status of Programs and Research within the NASA Orbital Debris Program Office

NASA Technical Reports Server (NTRS)

Bacon, Jack

2016-01-01

The NASA Orbital Debris Program Office (ODPO) is the world's longest-standing orbital debris research organization. It supports all aspects of international and US national policy-making related to the orbital environment and to spacecraft life cycle requirements. Representing more than just NASA projects, it is the United States' center of expertise in the field. The office continues to advance research in all aspects of orbital debris, including its measurement, modeling, and risk assessment for both orbital and ground safety concerns. This presentation will highlight current activities and recent progress in all aspects of the ODPO's mission.

There Is No Simple Model of the Plasma Membrane Organization

PubMed Central

Bernardino de la Serna, Jorge; Schütz, Gerhard J.; Eggeling, Christian; Cebecauer, Marek

2016-01-01

Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure. PMID:27747212

There Is No Simple Model of the Plasma Membrane Organization.

PubMed

Bernardino de la Serna, Jorge; Schütz, Gerhard J; Eggeling, Christian; Cebecauer, Marek

2016-01-01

Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure.

Recreation and leisure research from an active living perspective: taking a second look at urban trail use data

Treesearch

Paul H. Gobster

2005-01-01

This paper examines recreation and leisure research within the context of active living, and highlights an apparent gap between the current involvement of recreation and leisure researchers and the potential they could offer to this important and expanding area of inquiry. To illustrate this potential, I looked at two previous studies that focused on the recreational...

Dust in the wind: Soiling of solar devices : Is there a Holy Grail solution? (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kazmerski, Lawrence; Costa, Suellen C.; Machado, Marcelo; Diniz, Antonia Sonia A. C.

2016-09-01

Soiling, the sedimentation of particulate matter (on the size scale of 1/10 the diameter of a human hair) on the exposed surfaces of solar collectors, is a growing area of concern for solar-system performance, reliability, maintenance, and cost. In the case of photovoltaics (PV), the condition of this first-surface of interaction of the incident photons is critical for ensuring that the maximum-possible light reaches the conversion devices. This paper begins with a more than seven-decade historical look at the research invested into this problem, highlighting the motivation and milestones; the researchers and the progress. The current growing terrestrial markets for solar have brought a new focus on soiling and dust issues. That is because many of these new markets in the solar-rich geographic regions of our world are ironically also in the most dust-rich and soiling-prone ones as well. This paper continues to provide an overview of the status of current research efforts toward understanding the basic soiling mechanisms, the relationships to the PV technology approaches, the geographical differences (highlighting Brasil, India, and the MENA region) in the severity of the problem, the dust physics and chemistry—all relating to the current and future mitigation approaches. Included are some fundamental microscale through nanoscale examinations at how individual dust particles adhere to module glass surfaces—as well as how the particles might stick to each other under certain environmental conditions. These observations are used to show how fundamental science may lead to the macroscale engineering solutions of these soiling problems. This presentation is designed to both overview the soiling area and highlight some of the current and future research directions, speculate on short-term approaches preventing solar showstoppers, and speculate on some "holy-grail" schemes that might lead to the final solutions.

Biomarkers and patient selection for PI3K/Akt/mTOR targeted therapies: current status and future directions.

PubMed

Bartlett, John M S

2010-11-01

The phosphatidylinositol 3-kinase (PI3K)/Akt/ mammalian target of rapamycin (mTOR) pathway regulates a broad spectrum of physiologic and pathologic processes. In breast cancer mutation, amplification, deletion, methylation, and posttranslational modifications lead to significant dysregulation of this pathway leading to more aggressive and potentially drug-resistant disease. Multiple novel agents, targeting different nodes within the pathway are currently under development by both commercial and academic partners. The key to the successful validation of these markers is selection of the appropriate patient groups using biomarkers. This article reviews current progress in this area, highlighting the key molecular alterations described in genes within the PI3K/Akt/mTOR pathway that may have an effect on response to current and future therapeutic interventions. Herein, gaps in current knowledge are highlighted and suggestions for future research directions given that may facilitate biomarker development in partnership with current drug development.

The Race To X-ray Microbeam and Nanobeam Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ice, Gene E; Budai, John D; Pang, Judy

2011-01-01

X-ray microbeams are an emerging characterization tool with transformational implications for broad areas of science ranging from materials structure and dynamics, geophysics and environmental science to biophysics and protein crystallography. In this review, we discuss the race toward sub-10 nm- x-ray beams with the ability to penetrate tens to hundreds of microns into most materials and with the ability to determine local (crystal) structure. Examples of science enabled by current micro/nanobeam technologies are presented and we provide a perspective on future directions. Applications highlighted are chosen to illustrate the important features of various submicron beam strategies and to highlight themore » directions of current and future research. While it is clear that x-ray microprobes will impact science broadly, the practical limit for hard x-ray beam size, the limit to trace element sensitivity, and the ultimate limitations associated with near-atomic structure determinations are the subject of ongoing research.« less

Space flight nutrition research: platforms and analogs

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Uchakin, Peter N.; Tobin, Brian W.

2002-01-01

Conducting research during actual or simulated weightlessness is a challenging endeavor, where even the simplest activities may present significant challenges. This article reviews some of the potential obstacles associated with performing research during space flight and offers brief descriptions of current and previous space research platforms and ground-based analogs, including those for human, animal, and cell-based research. This review is intended to highlight the main issues of space flight research analogs and leave the specifics for each physiologic system for the other papers in this section.

Transportation and Aging: A Research Agenda for Advancing Safe Mobility

ERIC Educational Resources Information Center

Dickerson, Anne E.; Molnar, Lisa J.; Eby, David W.; Adler, Geri; Bedard, Michel; Berg-Weger, Marla; Classen, Sherrilene; Foley, Daniel; Horowitz, Amy; Kerschner, Helen; Page, Oliver; Silverstein, Nina M.; Staplin, Loren; Trujillo, Leonard

2007-01-01

Purpose: We review what we currently know about older driver safety and mobility, and we highlight important research needs in a number of key areas that hold promise for achieving the safety and mobility goals for the aging baby boomers and future generations of older drivers. Design and Methods: Through the use of a framework for transportation…

Current Research into Chemical and Textual Information Retrieval at the Department of Information Studies, University of Sheffield.

ERIC Educational Resources Information Center

Lynch, Michael F.; Willett, Peter

1987-01-01

Discusses research into chemical information and document retrieval systems at the University of Sheffield. Highlights include the use of cluster analysis methods for document retrieval and drug design, representation and searching of files of generic chemical structures, and the application of parallel computer hardware to information retrieval.…

Biogeochemical research priorities for sustainable biofuel and bioenergy feedstock production in the Americas

Treesearch

Hero T. Gollany; Brian D. Titus; D. Andrew Scott; Heidi Asbjornsen; Sigrid C. Resh; Rodney A. Chimner; Donald J. Kaczmarek; Luiz F.C. Leite; Ana C.C. Ferreira; Kenton A. Rod; Jorge Hilbert; Marcelo V. Galdos; Michelle E. Cisz

2015-01-01

Rapid expansion in biomass production for biofuels and bioenergy in the Americas is increasing demand on the ecosystem resources required to sustain soil and site productivity. We review the current state of knowledge and highlight gaps in research on biogeochemical processes and ecosystem sustainability related to biomass production. Biomass production systems...

Researching Refugee and Forced Migration Studies: An Introduction to the Field and the Reference Literature.

ERIC Educational Resources Information Center

Mason, Elisa

1999-01-01

Describes the evolution of refugee and forced migration studies, identifies factors that render it a challenging field to research, and highlights a variety of Internet-based and other electronic resources that can be used to locate monographs, periodicals, grey literature, and current information. Provides a bibliography of reference materials in…

Wireless Instrumentation Systems for Flight Testing at NASA AFRC

NASA Technical Reports Server (NTRS)

Hang, Richard

2017-01-01

NASA Armstrong Flight Research Center is revolutionizing its traditional wired instrumentation systems with wireless technologies. This effort faces many technical challenges, such as spectrum compliance, time synchronization, power distribution and airworthiness. This presentation summarizes NASA AFRC's flight test capabilities with current conventional instrumentation methodology and highlights the technical challenges of wireless systems used for flight test research applications.

NASA Lewis Research Center low-gravity fluid management technology program

NASA Technical Reports Server (NTRS)

Aydelott, J. C.; Carney, M. J.; Hochstein, J. I.

1985-01-01

A history of the Lewis Research Center in space fluid management technology program is presented. Current programs which include numerical modeling of fluid systems, heat exchanger/radiator concept studies, and the design of the Cryogenic Fluid Management Facility are discussed. Recent analytical and experimental activities performed to support the Shuttle/Centaur development activity are highlighted.

iPads: Improving Numeracy Learning in the Early Years

ERIC Educational Resources Information Center

Spencer, Peta

2013-01-01

The concept of mobile technologies is now an emergency theme in educational research, yet the playing of these edutainment applications and their impact on early childhood learning needs to be fully explored. This study highlights current research and explores how iPads improve student learning. It also examines how the introduction of iPads,…

On Open Access to Research: The Green, the Gold, and the Public Good

ERIC Educational Resources Information Center

Roach, Audra K.; Gainer, Jesse

2013-01-01

In this column the authors discuss barriers to worldwide open access to peer-reviewed journal articles online and how they might be addressed by literacy scholars. They highlight economic and ethical problems associated with the current subscription-based system for distributing articles (which sometimes works against the ideals of research and…

A Critical Appraisal of Issues in Differential Response: Moving the Field Forward

ERIC Educational Resources Information Center

Winokur, Marc A.; Gabel, George

2013-01-01

This reaction article highlights areas of agreement and disagreement with the study conducted by Hughes, Rycus, Saunders-Adams, Hughes, and Hughes on the current state of research and practice in differential response (DR). Overall, we agree with several of the arguments put forth by Hughes et al. regarding the limitations of DR research and the…

Review of the Literature Regarding Early Memories and Their Emerging Use in Projective Spiritual Assessment.

ERIC Educational Resources Information Center

Bustrum, Joy M.

This doctoral research seeks to demonstrate the clinical utility of early memories by reviewing the current literature and providing a rationale for extending this research into the spiritual arena by highlighting the lack of available projective spiritual measures. Specific areas covered include an overview of early memory theory, technique and…

[Play therapy in hospital].

PubMed

Gold, Katharina; Grothues, Dirk; Leitzmann, Michael; Gruber, Hans; Melter, Michael

2012-01-01

The following article presents an overview of current research studies on play therapy in the hospital. It highlights individual diagnoses for which play therapy has shown reasonable success. The aim of this review is to describe the current status of the scientific debate on play therapy for sick children in order to allow conclusions regarding the indications for which play therapy is or might be useful.

Current emotion research in cultural neuroscience

PubMed Central

Chiao, Joan Y.

2013-01-01

Classical theories of emotion have long debated the extent to which human emotion is a universal or culturally-constructed experience. Recent advances in emotion research in cultural neuroscience highlight several aspects of emotional generation and experience that are both phylogenetically conserved as well as constructed within human cultural contexts. This review highlights theories and methods from cultural neuroscience that examine how cultural and biological processes shape emotional generation, experience and regulation across multiple time scales. Recent advances in the neurobiological basis of culture-bound syndromes, such as Hwa-Byung (fire illness), provide further novel insights into emotion and mental health across cultures. Implications of emotion research in cultural neuroscience for population health disparities in psychopathology and global mental health will be discussed. PMID:26346827

Entamoeba histolytica: a snapshot of current research and methods for genetic analysis

PubMed Central

Morf, Laura; Singh, Upinder

2012-01-01

Entamoeba histolytica represents one of the leading causes of parasitic death worldwide. Although identified as the causative agent of amebiasis since 1875, the molecular mechanisms by which the parasite causes disease are still not fully understood. Studying Entamoeba reveals insights into a eukaryotic cell that differs in many ways from better-studied model organisms. Thus, much can be learned from this protozoan parasite on evolution, cell biology and RNA biology. In this review we discuss selected research highlights in Entamoeba research and focus on the development of molecular biological techniques to study this pathogen. We end by highlighting some of the many questions that remain to be answered in order to fully understand this important human pathogen. PMID:22664276

Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.

PubMed

Smith, Tracy T; Rupprecht, Laura E; Denlinger-Apte, Rachel L; Weeks, Jillian J; Panas, Rachel S; Donny, Eric C; Sved, Alan F

2017-09-01

A mandated reduction in the nicotine content of cigarettes may improve public health by reducing the prevalence of smoking. Animal self-administration research is an important complement to clinical research on nicotine reduction. It can fill research gaps that may be difficult to address with clinical research, guide clinical researchers about variables that are likely to be important in their own research, and provide policy makers with converging evidence between clinical and preclinical studies about the potential impact of a nicotine reduction policy. Convergence between clinical and preclinical research is important, given the ease with which clinical trial participants can access nonstudy tobacco products in the current marketplace. Herein, we review contributions of preclinical animal research, with a focus on rodent self-administration, to the science of nicotine reduction. Throughout this review, we highlight areas where clinical and preclinical research converge and areas where the two differ. Preclinical research has provided data on many important topics such as the threshold for nicotine reinforcement, the likelihood of compensation, moderators of the impact of nicotine reduction, the impact of environmental stimuli on nicotine reduction, the impact of nonnicotine cigarette smoke constituents on nicotine reduction, and the impact of nicotine reduction on vulnerable populations. Special attention is paid to current research gaps including the dramatic rise in alternative tobacco products, including electronic nicotine delivery systems (ie, e-cigarettes). The evidence reviewed here will be critical for policy makers as well as clinical researchers interested in nicotine reduction. This review will provide policy makers and clinical researchers interested in nicotine reduction with an overview of the preclinical animal research conducted on nicotine reduction and the regulatory implications of that research. The review also highlights the utility of preclinical research for research questions related to nicotine reduction. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Leading-edge vortex research: Some nonplanar concepts and current challenges

NASA Technical Reports Server (NTRS)

Campbell, J. F.; Osborn, R. F.

1986-01-01

Some background information is provided for the Vortex Flow Aerodynamics Conference and that current slender wing airplanes do not use variable leading edge geometry to improve transonic drag polar is shown. Highlights of some of the initial studies combining wing camber, or flaps, with vortex flow are presented. Current vortex flap studies were reviewed to show that there is a large subsonic data base and that transonic and supersonic generic studies have begun. There is a need for validated flow field solvers to calculate vortex/shock interactions at transonic and supersonic speeds. Many important research opportunities exist for fundamental vortex flow investigations and for designing advanced fighter concepts.

The Future of Qualitative Research in Psychology: Accentuating the Positive.

PubMed

Gough, Brendan; Lyons, Antonia

2016-06-01

In this paper we reflect on current trends and anticipate future prospects regarding qualitative research in Psychology. We highlight various institutional and disciplinary obstacles to qualitative research diversity, complexity and quality. At the same time, we note some causes for optimism, including publication breakthroughs and vitality within the field. The paper is structured into three main sections which consider: 1) the positioning of qualitative research within Psychology; 2) celebrating the different kinds of knowledge produced by qualitative research; and 3) implementing high quality qualitative research. In general we accentuate the positive, recognising and illustrating innovative qualitative research practices which generate new insights and propel the field forward. We conclude by emphasising the importance of research training: for qualitative research to flourish within Psychology (and beyond), students and early career researchers require more sophisticated, in-depth instruction than is currently offered.

Virtual Reality: An Overview.

ERIC Educational Resources Information Center

Franchi, Jorge

1994-01-01

Highlights of this overview of virtual reality include optics; interface devices; virtual worlds; potential applications, including medicine and archaeology; problems, including costs; current research and development; future possibilities; and a listing of vendors and suppliers of virtual reality products. (Contains 11 references.) (LRW)

Blog Posts by the NCI Director Dr. Norman Sharpless

Cancer.gov

NCI Director Dr. Norman Sharpless writes posts regularly for NCI's Cancer Currents Blog that highlight his vision for NCI, meetings with and partnerships in the cancer community, and strategic and scientific initiatives to advance cancer research and care.

The configuration of job placement for people with disabilities in the current economic contingencies in Italy: Social and clinical implications for health.

PubMed

Iudici, Antonio; Renzi, Cosimo

2015-10-01

In current socioeconomic conditions, working occupies a key role in people's lives, from both practical and existential perspectives. The absence of work can produce a considerable impact on the identity of individuals and entire communities. This emphasis on work is even more important for some groups in society, particularly for people with disabilities. In the Italian context, despite the existence of legislation on the subject, only 16% of people with disabilities have a job. This study was conducted to understand how people with disabilities become included in companies. This research proposes to highlight the ways in which corporate bodies' roles relate to people with disabilities' work in order to assess related theories, beliefs and critical aspects. Using the M.A.D.I.T. (Methodology of Textual Analysis of Computerized Data), some companies' placement managers for people with disabilities were interviewed. This analysis highlights conditions explaining current difficulties, especially in the absence of agreed upon criteria and a delegation. This research highlights the need to carry out a structural reorganization for the relationship between companies and employment agencies to avoid the risk that the lack of communication between the involved parties and the lack of support in the employment process may force companies to consider people with disabilities as an obstacle rather than a resource. Copyright © 2015 Elsevier Inc. All rights reserved.

Latest discoveries and trends in translational cancer research: highlights of the 2008 Annual Meeting of the American Association for Cancer Research.

PubMed

Cho, William C S

2008-08-01

The Annual Meeting of the American Association for Cancer Research (AACR) is the world's largest and most comprehensive gathering of cancer researchers. At the 2008 AACR Annual Meeting, innovative research approaches, novel technologies, potentially life-saving therapies in the pipeline, late-breaking clinical trial findings, and new approaches to cancer prevention were presented by top scientists. Reflecting the global state of cancer research with an eye toward future trends, several areas of great science and discovery in the cancer field were shared in this report, which include cancer biomarkers, the role of microRNAs in cancer research, cancer stem cells, tumor microenvironment, targeted therapy, and cancer prevention. This article presents an overview of hot topics discussed at the 2008 AACR Annual Meeting and recapitulates some scientific sessions geared toward new technologies, recent progress, and current challenges reported by cancer researchers. For those who did not attend the meeting, this report may serve as a highlight of this important international cancer research meeting.

Using the Internet to Improve HRD Research: The Case of the Web-Based Delphi Research Technique to Achieve Content Validity of an HRD-Oriented Measurement

ERIC Educational Resources Information Center

Hatcher, Tim; Colton, Sharon

2007-01-01

Purpose: The purpose of this article is to highlight the results of the online Delphi research project; in particular the procedures used to establish an online and innovative process of content validation and obtaining "rich" and descriptive information using the internet and current e-learning technologies. The online Delphi was proven to be an…

Transmission research activities at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Lewicki, D. G.

1990-01-01

A joint research program, to advance the technology of rotorcraft transmissions, consists of analytical and experimental efforts to achieve the overall goals of reducing transmission weight and noise, while increasing life and reliability. Recent activities in the areas of transmission and related component research are highlighted. Current areas include specific technologies in support of military rotary wing aviation, gearing technology, transmission noise reduction studies, a recent interest in gearbox diagnostics, and advanced transmission system studies. Results of recent activities are presented along with near term research plans.

Institutional Ethics Committee Regulations and Current Updates in India.

PubMed

Mahuli, Amit V; Mahuli, Simpy A; Patil, Shankargouda; Bhandi, Shilpa

2017-08-01

The aim of the review is to provide current updates on regulations for ethics committees and researchers in India. Ethical dilemmas in research since time immemorial have been a major concern for researchers worldwide. The question "what makes clinical research ethical" is significant and difficult to answer as multiple factors are involved. The research involving human participants in clinical trials should follow the required rules, regulations, and guidelines in one's own country. It is a dynamic process, and updates have to be learned by researcher and committee members. The review highlights the ethical regulation from the Drug Controller General of India, Clinical Trial Registry of India, and Indian Council of Medical Research guidelines. In this article, the updates on Indian scenario of the Ethical Committee and guidelines are compiled. The review comes handy for clinical researchers and ethics committee members in academic institutions to check on the current updates and keep abreast with the knowledge on regulations of ethics in India.

Visual Analytics 101

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholtz, Jean; Burtner, Edwin R.; Cook, Kristin A.

This course will introduce the field of Visual Analytics to HCI researchers and practitioners highlighting the contributions they can make to this field. Topics will include a definition of visual analytics along with examples of current systems, types of tasks and end users, issues in defining user requirements, design of visualizations and interactions, guidelines and heuristics, the current state of user-centered evaluations, and metrics for evaluation. We encourage designers, HCI researchers, and HCI practitioners to attend to learn how their skills can contribute to advancing the state of the art of visual analytics

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

PubMed

Shalev, Idan; Belsky, Jay

2016-05-01

Two seemingly independent bodies of research suggest a two-hit model of accelerated aging, one highlighting early-life stress and the other reproduction. The first, informed by developmental models of early-life stress, highlights reduced longevity effects of early adversity on telomere erosion, whereas the second, informed by evolutionary theories of aging, highlights such effects with regard to reproductive cost (in females). The fact that both early-life adversity and reproductive effort are associated with shorter telomeres and increased oxidative stress raises the prospect, consistent with life-history theory, that these two theoretical frameworks currently informing much research are tapping into the same evolutionary-developmental process of increased senescence and reduced longevity. Here we propose a mechanistic view of a two-hit model of accelerated aging in human females through (a) early-life adversity and (b) early reproduction, via a process of telomere erosion, while highlighting mediating biological embedding mechanisms that might link these two developmental aging processes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Workshop Report UK Food Standards Agency Workshop Report: carbohydrate and cardiovascular risk

PubMed Central

Peacock, Emma; Stanley, John; Calder, Philip C.; Jebb, Susan A.; Thies, Frank; Seal, Chris J.; Woodside, Jayne V.; Sanders, Tom A. B.

2012-01-01

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 14 October 2008 to discuss current FSA-funded research on carbohydrates and cardiovascular health. The objective of this workshop was to discuss the results of recent research and to identify any areas which could inform future FSA research calls. This workshop highlighted that the FSA is currently funding some of the largest, well-powered intervention trials investigating the type of fat and carbohydrate, whole grains and fruit and vegetables, on various CVD risk factors. Results of these trials will make a substantive contribution to the evidence on diet and cardiovascular risk. PMID:20236556

Monofluoroacetate-containing plants that are potentially toxic to livestock

USDA-ARS?s Scientific Manuscript database

Many plants worldwide contain monofluoroacetate and cause sudden death in livestock. These plants are primarily found in the southern continents of Africa, Australia and South America where they negatively impact livestock production. This review highlights past and current research investigating: ...

Highlights of the Transit Bus Technology Workshop - April 29-30, 1982

DOT National Transportation Integrated Search

1982-09-01

The Transit Bus Technology Workshop, held at the Transportation Systems Center on April 29-30, 1982, provided UMTA with current information on research, development, and technical assistance needed to improve the economy and performance of transit bu...

Nanotechnology and nuclear medicine; research and preclinical applications.

PubMed

Assadi, Majid; Afrasiabi, Kolsoom; Nabipour, Iraj; Seyedabadi, Mohammad

2011-01-01

The birth of nanotechnology in human society was around 2000 years ago and soon found applications in various fields. In this article, we highlight the current status of research and preclinical applications and also future prospects of nanotechnology in medicine and in nuclear medicine. The most important field is cancer. A regular nanotechnology training program for nuclear medicine physicians may be welcome.

"Oh, Those Loud Black Girls!": A Phenomenological Study of Black Girls Talking with an Attitude

ERIC Educational Resources Information Center

Koonce, Jacqueline B.

2012-01-01

Current research suggests that it is imperative for researchers and educators to pay more attention to the needs of African American adolescent girls and how their race and gender affect schooling (Fordham, 1993; Morris, 2007). The purpose of this study was to highlight the lived experiences of two African American adolescent girls when they used…

"Making Children Count": An Exploration of the Implementation of the Every Child Matters Agenda

ERIC Educational Resources Information Center

Ainslie, Susan; Foster, Rob; Groves, Jean; Grime, Kate; Straker, Katherine; Woolhouse, Clare

2010-01-01

This paper reports on the findings of a funded research project that explores the implementation of the Every Child Matters (ECM) agenda within the Greater Merseyside area. The research team explore how primary schools and external agencies are currently working together to deliver this agenda in order to highlight areas of good practice as well…

Current status of quantitative rotational spectroscopy for atmospheric research

NASA Technical Reports Server (NTRS)

Drouin, Brian J.; Wlodarczak, Georges; Colmont, Jean-Marcel; Rohart, Francois

2004-01-01

Remote sensing of rotational transitions in the Earth's atmosphere has become an important method for the retrieval of geophysical temperatures, pressures and chemical composition profiles that requires accurate spectral information. This paper highlights the current status of rotational data that are useful for atmospheric measurements, with a discussion of the types the rotational lineshape measurements that are not generally available in either online repository.

Progress in space power technology

NASA Technical Reports Server (NTRS)

Mullin, J. P.; Randolph, L. P.; Hudson, W. R.

1980-01-01

The National Aeronautics and Space Administration's Space Power Research and Technology Program has the objective of providing the technology base for future space power systems. The current technology program which consists of photovoltaic energy conversion, chemical energy conversion and storage, thermal-to-electric conversion, power systems management and distribution, and advanced energetics is discussed. In each area highlights, current programs, and near-term directions will be presented.

Current Research at the University of Chicago Enrico Fermi Institute and James Franck Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swordy, Simon

2009-03-04

These talks will give an overview of physics research at the University of Chicago centered in two research institutes. The Enrico Fermi Institute pursues research in some core areas of the physical sciences. These include cosmology, particle physics, theoretical physics, particle astrophysics, and cosmochemistry. The EFI talk will focus on some examples of these activities which together will provide a broad overview of EFI science. Research at the James Franck Institute centers on the intersection between physics, chemistry and materials science, with the aim to unravel the complex connections between structure and dynamics in condensed matter systems. The JFI ismore » also home to the Chicago Materials Research Science and Engineering Center. The JFI talk will provide highlights of current projects by JFI members.« less

Current Research at the University of Chicago Enrico Fermi Institute and James Franck Institute

ScienceCinema

Swordy, Simon

2017-12-22

These talks will give an overview of physics research at the University of Chicago centered in two research institutes. The Enrico Fermi Institute pursues research in some core areas of the physical sciences. These include cosmology, particle physics, theoretical physics, particle astrophysics, and cosmochemistry. The EFI talk will focus on some examples of these activities which together will provide a broad overview of EFI science. Research at the James Franck Institute centers on the intersection between physics, chemistry and materials science, with the aim to unravel the complex connections between structure and dynamics in condensed matter systems. The JFI is also home to the Chicago Materials Research Science and Engineering Center. The JFI talk will provide highlights of current projects by JFI members.

Susceptibility to chronic inflammation: an update.

PubMed

Nasef, Noha Ahmed; Mehta, Sunali; Ferguson, Lynnette R

2017-03-01

Chronic inflammation is defined by the persistence of inflammatory processes beyond their physiological function, resulting in tissue destruction. Chronic inflammation is implicated in the progression of many chronic diseases and plays a central role in chronic inflammatory and autoimmune disease. As such, this review aims to collate some of the latest research in relation to genetic and environmental susceptibilities to chronic inflammation. In the genetic section, we discuss some of the updates in cytokine research and current treatments that are being developed. We also discuss newly identified canonical and non-canonical genes associated with chronic inflammation. In the environmental section, we highlight some of the latest updates and evidence in relation to the role that infection, diet and stress play in promoting inflammation. The aim of this review is to provide an overview of the latest research to build on our current understanding of chronic inflammation. It highlights the complexity associated with chronic inflammation, as well as provides insights into potential new targets for therapies that could be used to treat chronic inflammation and consequently prevent disease progression.

National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".

PubMed

Zhong, Guangming; Brunham, Robert C; de la Maza, Luis M; Darville, Toni; Deal, Carolyn

2017-10-31

Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection, and this highlights the need for the development of an effective Ct vaccine. To this end, NIAID organized a workshop to consider the current status of Ct vaccine research and address critical questions in Ct vaccine design and clinical testing. Topics included the goal(s) of a vaccine and the feasibility of achieving these goals, animal models of infection including mouse and nonhuman primate (NHP) models, and correlates of protection to guide vaccine design. Decades of research have provided both whole cell-based and subunit vaccine candidates for development. At least one is currently in clinical development and efforts now need to be directed toward further development of the most attractive candidates. Overall, the discussions and presentations from the workshop highlighted optimism about the current status of Ct vaccine research and detailed the remaining gaps and questions needed to move vaccines forward. Copyright © 2017 Elsevier Ltd. All rights reserved.

In vivo confocal microscopy in dermatology: from research to clinical application

NASA Astrophysics Data System (ADS)

Ulrich, Martina; Lange-Asschenfeldt, Susanne

2013-06-01

Confocal laser scanning microscopy (CLSM) represents an emerging technique for the noninvasive histomorphological analysis of skin in vivo and has shown its applicability for dermatological research as well as its value as an adjunct tool in the clinical management of skin cancer patients. Herein, we aim to give an overview on the current clinical indications for CLSM in dermatology and also highlight the diverse applications of CLSM in dermatological research.

United States Department of Agriculture-Agricultural Research Service research on pest biology: weeds.

PubMed

Forcella, Frank

2003-01-01

Over 125 permanent full-time scientists conduct research within the USDA Agricultural Research Service (ARS) on issues related to weeds. The research emphasis of most of these scientists involves ecology and management or biological control of weeds. Many scientists perform research on weed biology as components of their primary projects on weed control and integrated crop and soil management. Describing all ARS projects involved with weed biology is impossible, and consequently only research that falls within the following arbitrarily chosen topics is highlighted in this article: dormancy mechanisms; cell division; diversity of rangeland weeds; soil resources and rangeland weeds; poisonous rangeland plants; horticultural weeds; weed traits limiting chemical control; aquatic and semi-aquatic weeds; weed/transgenic wheat hybrids; seedbanks, seedling emergence and seedling populations; and weed seed production. Within these topics, and others not highlighted, the desire of ARS is that good information on weed biology currently translates or eventually will translate into practical advice for those who must manage weeds.

The effect of childhood sexual abuse on adolescent pregnancy: an integrative research review.

PubMed

Francisco, Melissa A; Hicks, Kasey; Powell, Julianne; Styles, Kristin; Tabor, Jessica L; Hulton, Linda J

2008-10-01

This study aims to describe the current research literature on the relationship of childhood sexual abuse and adolescent pregnancy and highlight the potential cross-cutting risk factors. Thirteen articles were identified as the basis of this review using Cooper's methodology (1998) for synthesizing research. Articles were categorized according to the levels of evidence proposed by Melnyk and Fineout-Overholt (2005). The majority of the studies identified a relationship between childhood sexual abuse and adolescent pregnancy (n=9). Cross-cutting risk factors included female gender, younger age, substance use/abuse, family constellation, parent-child conflict, and mother disengagement. Strategies for nurses to identify pregnant and parenting adolescents who have been sexually victimized are important for early intervention. Resiliency factors of young people who report positive outcomes are highlighted.

Highlights of Recent Research Activities at the NASA Orbital Debris Program Office

NASA Technical Reports Server (NTRS)

Liou, J - C.

2017-01-01

The NASA Orbital Debris Program Office (ODPO) was established at the NASA Johnson Space Center in 1979. The ODPO has initiated and led major orbital debris research activities over the past 38 years, including developing the first set of the NASA orbital debris mitigation requirements in 1995 and supporting the establishment of the U.S. Government Orbital Debris Mitigation Standard Practices in 2001. This paper is an overview of the recent ODPO research activities, ranging from ground-based and in-situ measurements, to laboratory tests, and to engineering and long-term orbital debris environment modeling. These activities highlight the ODPO's commitment to continuously improve the orbital debris environment definition to better protect current and future space missions from the low Earth orbit to the geosynchronous Earth orbit regions.

Study Designs and Statistical Analyses for Biomarker Research

PubMed Central

Gosho, Masahiko; Nagashima, Kengo; Sato, Yasunori

2012-01-01

Biomarkers are becoming increasingly important for streamlining drug discovery and development. In addition, biomarkers are widely expected to be used as a tool for disease diagnosis, personalized medication, and surrogate endpoints in clinical research. In this paper, we highlight several important aspects related to study design and statistical analysis for clinical research incorporating biomarkers. We describe the typical and current study designs for exploring, detecting, and utilizing biomarkers. Furthermore, we introduce statistical issues such as confounding and multiplicity for statistical tests in biomarker research. PMID:23012528

The case for entrepreneurship in R&D in the pharmaceutical industry.

PubMed

Douglas, Frank L; Narayanan, V K; Mitchell, Lesa; Litan, Robert E

2010-09-01

A lack of entrepreneurial behaviour has often been highlighted as a contributor to the decline in the research and development (R&D) productivity of the pharmaceutical industry. Here, we present an assessment of entrepreneurship in the industry, based on interviews with 26 former and current leaders of R&D departments at major pharmaceutical and biotechnology companies. Factors are highlighted that could be important in promoting entrepreneurial behaviour, which might serve as a catalyst for revitalizing R&D productivity.

Structural dynamics division research and technology accomplishments for F.Y. 1991 and plans for F.Y. 1992

NASA Technical Reports Server (NTRS)

Wynne, Eleanor C.

1992-01-01

The work under each technical area is described in terms of highlights of accomplishments during the past year and highlights of plans for the current year as they relate to 5 year plans for each technical area. This information will be useful in program coordination with other government organizations and industry in areas of mutual interest. The structural dynamics division consist of the following branches: configuration aeroelasticity; unsteady aerodynamics; aeroservoelasticity; landing and impact dynamics; and spacecraft dynamics.

Silent Suffering: Children with Selective Mutism

ERIC Educational Resources Information Center

Camposano, Lisa

2011-01-01

Despite increasing awareness, the childhood disorder of selective mutism is under-researched and commonly misdiagnosed. The purpose of this article is to highlight current issues related to this disorder as well as describe various treatment approaches including behavioral, cognitive-behavioral, psychodynamic, family, and pharmacological…

Review of Potential Wind Tunnel Balance Technologies

NASA Technical Reports Server (NTRS)

Burns, Devin E.; Williams, Quincy L.; Phillips, Ben D.; Commo, Sean A.; Ponder, Jonathon D.

2016-01-01

This manuscript reviews design, manufacture, materials, sensors, and data acquisition technologies that may benefit wind tunnel balances for the aerospace research community. Current state-of-the-art practices are used as the benchmark to consider advancements driven by researcher and facility needs. Additive manufacturing is highlighted as a promising alternative technology to conventional fabrication and has the potential to reduce both the cost and time required to manufacture force balances. Material alternatives to maraging steels are reviewed. Sensor technologies including piezoresistive, piezoelectric, surface acoustic wave, and fiber optic are compared to traditional foil based gages to highlight unique opportunities and shared challenges for implementation in wind tunnel environments. Finally, data acquisition systems that could be integrated into force balances are highlighted as a way to simplify the user experience and improve data quality. In summary, a rank ordering is provided to support strategic investment in exploring the technologies reviewed in this manuscript.

Rape: psychopathology, theory and treatment.

PubMed

Gannon, Theresa A; Collie, Rachael M; Ward, Tony; Thakker, Jo

2008-07-01

Whether treatment programs are effective at rehabilitating rapists is yet to be determined empirically. From a scientist-practitioner perspective, treatment should be based on an empirical understanding of rape and rapists, and evidence-based knowledge of treatment outcome with rapists. In this paper we comprehensively review the characteristics of rapists, etiological features implicated in the commission of rape, and relevant treatment outcome research. We pay particular attention to contemporary knowledge about the core vulnerabilities and features required to understand and treat rapists effectively, and, where possible, highlight similarities and differences between rapists, child molesters and non-sexual violent offenders. We use an epistemological framework to (a) critique the various etiological accounts of rape available and (b) help guide professionals' use of such knowledge in both treatment design and evaluation. Gaps in the understanding of rapists' characteristics and etiological features are highlighted, as are discrepancies between current knowledge and treatment approaches. We conclude by highlighting areas for future research and practice innovation.

Social network analysis of a project-based introductory physics course

NASA Astrophysics Data System (ADS)

Oakley, Christopher

2016-03-01

Research suggests that students benefit from peer interaction and active engagement in the classroom. The quality, nature, effect of these interactions is currently being explored by Physics Education Researchers. Spelman College offers an introductory physics sequence that addresses content and research skills by engaging students in open-ended research projects, a form of Project-Based Learning. Students have been surveyed at regular intervals during the second semester of trigonometry-based course to determine the frequency of interactions in and out of class. These interactions can be with current or past students, tutors, and instructors. This line of inquiry focuses on metrics of Social Network analysis, such as centrality of participants as well as segmentation of groups. Further research will refine and highlight deeper questions regarding student performance in this pedagogy and course sequence.

NASA Efforts on Nanotechnology

NASA Technical Reports Server (NTRS)

Miranda, Felix A.

2003-01-01

An overview of the field of nanotechnology within the theme of "New efforts in Nanotechnology Research," will be presented. NASA's interest, requirements and current efforts in this emerging field will be discussed. In particular, NASA efforts to develop nanoelectronic devices, fuel cells, and other applications of interest using this novel technology by collaborating with academia will be addressed. Progress on current collaborations in this area with the University of Puerto Rico will be highlighted.

The VESUVIO Spectrometer Now and When?

NASA Astrophysics Data System (ADS)

Seel, A. G.; Krzystyniak, M.; Fernandez-Alonso, F.

2014-12-01

The current layout and mechanics of the VESUVIO spectrometer are presented in light of spectroscopic measurements using electron-volt neutrons. A brief background to the theoretical framework of deep inelastic neutron scattering is presented, with focus on data collection and instrumental design. The current capabilities and research themes for VESUVIO are discussed, and possible future instrumental developments highlighted which will enhance the instrument's ability to meet scientific inquiry and expectation.

Ascorbic acid, cognitive function, and Alzheimer’s disease: a current review and future direction

PubMed Central

Bowman, Gene L.

2013-01-01

This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer’s disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport into brain tissue. A final synopsis highlights areas for future research regarding AA nourishment and healthy brain aging. PMID:22419527

Special issue: engineering toxins for 21st-century therapies: introduction.

PubMed

Acharya, K Ravi

2011-12-01

This special issue on 'Engineering toxins for 21st century therapies' provides a critical review of the current state of multifaceted aspects of toxin research by some of the leading researchers in the field. It also highlights the clinical potential and challenges for development of novel biologics based on engineered toxin derived products. © 2011 The Author Journal compilation © 2011 FEBS.

An Overview of the NASA Fundamental Aeronautics Program Subsonic Fixed Wing Project and Ultra High Bypass Partnership Research Goals

NASA Technical Reports Server (NTRS)

Hughes, Christopher E.

2009-01-01

An overview of the NASA Fundamental Aeronautics Program (FAP) mission and goals is presented. One of the subprograms under the FAP, the Subsonic Fixed Wing Project (SFW), is the focus of the presentation. The SFW system environmental metrics are discussed, along with highlights of planned, systematic approach to research to reduce the environmental impact of commercial aircraft in the areas of acoustics, fuel burn and emissions. The presentation then focuses on collaborative research being conducted with U.S. Industry on the Ultra High Bypass (UHB) engine cycle, the propulsion cycle selected by the SFW to meet the system goals. The partnerships with General Electric Aviation to investigate Open Rotor propulsion concepts and with Pratt & Whitney to investigate the Geared Turbofan UHB engine are highlighted, including current and planned future collaborative research activities with NASA and each organization.

Culture: The missing link in health research.

PubMed

Kagawa Singer, M; Dressler, W; George, S

2016-12-01

Culture is essential for humans to exist. Yet surprisingly little attention has been paid to identifying how culture works or developing standards to guide the application of this concept in health research. This paper describes a multidisciplinary effort to find consensus on essential elements of a definition of culture to guide researchers in studying how cultural processes influence health and health behaviors. We first highlight the lack of progress made in the health sciences to explain differences between population groups, and then identify 10 key barriers in research impeding progress in more effectively and rapidly realizing equity in health outcomes. Second, we highlight the primarily mono-cultural lens through which health behavior is currently conceptualized, third, we present a consensus definition of culture as an integrating framework, and last, we provide guidelines to more effectively operationalize the concept of culture for health research. We hope this effort will be useful to researchers, reviewers, and funders alike. Copyright © 2016 Elsevier Ltd. All rights reserved.

Highlights of the 2009 SEG summer research workshop on"CO2 Sequestration Geophysics"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lumley, D.; Sherlock, D.; Daley, T.

The 2009 SEG Summer Research Workshop on CO2 Sequestration Geophysics was held August 23-27, 2009 in Banff, Canada. The event was attended by over 100 scientists from around the world, which proved to be a remarkably successful turnout in the midst of the current global financial crisis and severe corporate travel restrictions. Attendees included SEG President Larry Lines (U. Calgary), and CSEG President John Downton (CGG Veritas), who joined SRW Chairman David Lumley (UWA) in giving the opening welcome remarks at the Sunday Icebreaker. The workshop was organized by an expert technical committee (see side bar) representing a good mixmore » of industry, academic, and government research organizations. The format consisted of four days of technical sessions with over 60 talks and posters, plus an optional pre-workshop field trip to the Columbia Ice Fields to view firsthand the effects of global warming on the Athabasca glacier (Figures 1-2). Group technical discussion was encouraged by requiring each presenter to limit themselves to 15 minutes of presentation followed by a 15 minute open discussion period. Technical contributions focused on the current and future role of geophysics in CO2 sequestration, highlighting new research and field-test results with regard to site selection and characterization, monitoring and surveillance, using a wide array of geophysical techniques. While there are too many excellent contributions to mention all individually here, in this paper we summarize some of the key workshop highlights in order to propagate new developments to the SEG community at large.« less

Highlights of the 2009 SEG summer research workshop on ""CO2 sequestration geophysics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Lianjie; Lumley, David; Sherlock, Don

The 2009 SEG Summer Research Workshop on 'CO{sub 2} Sequestration Geophysics' was held August 23-27, 2009 in Banff, Canada. The event was attended by over 100 scientists from around the world, which proved to be a remarkably successful turnout in the midst of the current global financial crisis and severe corporate travel restrictions. Attendees included SEG President Larry Lines (U. Calgary), and CSEG President John Downton (CGG Veritas), who joined SRW Chairman David Lumley (UWA) in giving the opening welcome remarks at the Sunday Icebreaker. The workshop was organized by an expert technical committee representing a good mix of industry,more » academic, and government research organizations. The format consisted of four days of technical sessions with over 60 talks and posters, plus an optional pre-workshop field trip to the Columbia Ice Fields to view firsthand the effects of global warming on the Athabasca glacier. Group technical discussion was encouraged by requiring each presenter to limit themselves to 15 minutes of presentation followed by a 15 minute open discussion period. Technical contributions focused on the current and future role of geophysics in CO{sub 2} sequestration, highlighting new research and field-test results with regard to site selection and characterization, monitoring and surveillance, using a wide array of geophysical techniques. While there are too many excellent contributions to mention all individually here, in this paper we summarize some of the key workshop highlights in order to propagate new developments to the SEG community at large.« less

Ethical issues in neonatal and pediatric clinical trials.

PubMed

Laventhal, Naomi; Tarini, Beth A; Lantos, John

2012-10-01

Children have been identified as uniquely vulnerable clinical research subjects since the early 1970s. This article reviews the historical underpinnings of this designation, the current regulatory framework for pediatric and neonatal research, and common problems in pediatric research oversight. It also presents 3 areas of pediatric and neonatal research (genomic screening, healthy children donating stem cells, and therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy) that highlight contemporary challenges in pediatric research ethics, including balancing risk and benefit, informed consent and assent, and clinical equipoise. Copyright © 2012 Elsevier Inc. All rights reserved.

Arab Parents' Involvement in School Reform in Israel

ERIC Educational Resources Information Center

Arar, Khalid; Abu-Asbah, Khaled; Nasra, Muhammed Abu

2014-01-01

Current research indicates that parental involvement positively influences children's academic success. This study investigates parental involvement in the Arab education system in Israel, highlighting involvement in the New Horizon reform. We interviewed school principals and parent committee chairpersons from 15 Arab schools. The study confirmed…

Economic Trends and Higher Education.

ERIC Educational Resources Information Center

Ottinger, Cecilia A.

1992-01-01

This research brief highlights current and projected economic trends that affect higher education and discusses some of their implications. The brief is organized into three sections: (1) national economic conditions affecting higher education, which presents data on gross national product, inflation, the Higher Education Price Index, the federal…

The Fraser Experimental Forest, Colorado

Treesearch

Robert R. Alexander; Ross K. Watkins

1977-01-01

This report provides a general overview of work done on the Fraser Experimental Forest. It replaces Station Paper No.8, published in 1952 and revised by L. D. Love in 1960. Included are descriptions of physical features and resource values, and highlights of past and current research programs.

Indexing and Retrieval for the Web.

ERIC Educational Resources Information Center

Rasmussen, Edie M.

2003-01-01

Explores current research on indexing and ranking as retrieval functions of search engines on the Web. Highlights include measuring search engine stability; evaluation of Web indexing and retrieval; Web crawlers; hyperlinks for indexing and ranking; ranking for metasearch; document structure; citation indexing; relevance; query evaluation;…

Plunging Plates Cause a Stir.

ERIC Educational Resources Information Center

Weisburd, Stefi

1986-01-01

Reviews current ideas and research findings related to the flow patterns of mantle rocks. Highlights the components of the two-layer convection and whole-mantle models of mantle flow. Proposes that mantle flow is the key to understanding how the earth has cooled and chemically evolved. (ML)

The Principal as Technology Leader.

ERIC Educational Resources Information Center

Creighton, Theodore

This book explores the complexities of change and implementation of technology in schools. It looks at current research while providing guidelines to development and planning, and includes sample technology plans. In addition, the book highlights instructional leadership and curriculum, the digital divide between needs and availability, needs…

Generalized Database Management System Support for Numeric Database Environments.

ERIC Educational Resources Information Center

Dominick, Wayne D.; Weathers, Peggy G.

1982-01-01

This overview of potential for utilizing database management systems (DBMS) within numeric database environments highlights: (1) major features, functions, and characteristics of DBMS; (2) applicability to numeric database environment needs and user needs; (3) current applications of DBMS technology; and (4) research-oriented and…

Surgical Management of Osteoarthritis of the Knee: Evidence-based Guideline.

PubMed

McGrory, Brian J; Weber, Kristy L; Jevsevar, David S; Sevarino, Kaitlyn

2016-08-01

Surgical Management of Osteoarthritis of the Knee: Evidence-based Guideline is based on a systematic review of the current scientific and clinical research. The guideline contains 38 recommendations pertaining to the preoperative, perioperative, and postoperative care of patients with osteoarthritis (OA) of the knee who are considering surgical treatment. The purpose of this clinical practice guideline is to help improve surgical management of patients with OA of the knee based on current best evidence. In addition to guideline recommendations, the work group highlighted the need for better research on the surgical management of OA of the knee.

Ahead of the Curve; Hidden breakthroughs in the biosciences

NASA Astrophysics Data System (ADS)

Levin, Michael; Adams, Dany Spencer

2016-12-01

This unique book is a compendium of carefully curated published papers in the biosciences, which have (or will) precipitate a profound change in prevailing paradigms and research programs. A mix of new and classic papers, it shows the limitations of current thought or identifies novel vistas for investigations that have not yet been explored. The purpose of the book is to highlight scientific gems, most unrecognized, that suggest revisions to key pillars of thought in the biological sciences and further the education of young scientists. This will be achieved by including reprints of papers that demonstrate counter-paradigm, novel directions for future research featuring commentary from current, notable researchers in a variety of areas.

Windows on the human body--in vivo high-field magnetic resonance research and applications in medicine and psychology.

PubMed

Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph S; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

2010-01-01

Analogous to the evolution of biological sensor-systems, the progress in "medical sensor-systems", i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given.

An overview of current activities at the National Solar Thermal Test Facility

NASA Astrophysics Data System (ADS)

Cameron, C. P.; Klimas, P. C.

This paper is a description of the United States Department of Energy's National Solar Thermal Test Facility, highlighting current test programs. In the central receiver area, research underway supports commercialization of molten nitrate salt technology, including receivers, thermal energy transport, and corrosion experiments. Concentrator research includes large-area, glass-metal heliostats and stretched-membrane heliostats and dishes. Test activities in support of dish-Stirling systems with reflux receivers are described. Research on parabolic troughs includes characterization of several receiver configurations. Other test facility activities include solar detoxification experiments, design assistance testing of commercially-available solar hardware, and non-DOE-funded work, including thermal exposure tests and testing of volumetric and PV central receiver concepts.

In-Situ Resource Utilization for the Moon, Mars and Beyond...

NASA Technical Reports Server (NTRS)

Trigwell, Steve

2010-01-01

For any future manned exploration to the moon, Mars, or beyond, there is a significant need to reduce the cost and logistics of transporting the raw materials such as oxygen, water, and fuel required to sustain human activity. Current research at Kennedy Space Center is focused on utilizing the resources at the destination to produce these requirements on-site, i.e. to live off the land. This program, known as In-situ Resource Utilization (ISRU), is the focus of the Applied Science and Technology research group here at KSC. This slide presentation will introduce the laboratories and highlight current research in ISRU to produce oxygen, water, and fuel components from lunar and Martian regolith.

The effects of medication use in transcranial direct current stimulation: A brief review.

PubMed

McLaren, Molly E; Nissim, Nicole R; Woods, Adam J

There has been increased interest in the potential use of transcranial direct current stimulation (tDCS) as treatment for multiple conditions including depression, pain, and cognitive impairment. However, few studies account for the possible influence of comorbid medications when conducting tDCS research. This literature review was conducted to examine what is currently known about the impact of medications on tDCS, provide recommendations for future research practices, and highlight areas where more research is needed. Key terms were searched in PubMed and Web of Science to identify studies that examine the impact of medication on tDCS effects in adults. Relevant papers' reference lists were also reviewed for thoroughness. Studies examined the effects of medication on 1 mA tDCS delivered to M1 (motor) and orbit/supraorbital (SO) area. All studies measured the effects of tDCS via MEP TMS paradigm. Results of the literature review suggest multiple classes of medications, including sodium and calcium channel blockers, and medications that influence various neurotransmitter systems (GABA, dopamine, serotonin, etc.) may all impact tDCS effects on tissue excitability. Research to date suggests multiple classes of medications may impact tDCS effects. These results highlight the importance of documenting medication use in research subjects and carefully considering what types of medications should be allowed into tDCS trials. Many questions still remain regarding the exact mechanisms of action for tDCS and how various parameters (medication dosages, tDCS stimulation intensity, etc.) may further impact the effects of medications on tDCS. Copyright © 2017 Elsevier Inc. All rights reserved.

The Selective Task Trainer: The Expert Solution.

ERIC Educational Resources Information Center

Gerson, Charles W.

1995-01-01

Examines simulator classification and design in light of new technology, current research, and a changing focus for using flight simulators in the military, and proposes a selective task trainer that addresses the expert's performance needs. Highlights include motor skill physiology; retention; automaticity skills; the novice to expert…

MINE WASTE TECHNOLOGY PROGRAM:HISTORICAL PERSPECTIVES. CURRENT HIGHLIGHTS, FUTURE OPPORTUNITIES

EPA Science Inventory

For the past 13 years, the Mine Waste Technology Program has been technically driven by the National Risk Management Research Lab. A portion of the MWTP funding has been used to perform field demonstrations of innovative technologies with the potential to address mine waste issue...

Multicultural Counseling Training: Past, Present, and Future Directions.

ERIC Educational Resources Information Center

Abreu, Jose M.; Chung, Ruth H. Gim; Atkinson, Donald R.

2000-01-01

Provides a selective review of the multicultural counseling training (MCT) literature. A brief historical account of multicultural counseling is followed by three other sections detailing current models of MCT, conceptualization of training objectives, and empirical research. Highlights and discusses critical issues for the present and future…

Fragile X Syndrome

ERIC Educational Resources Information Center

Schwarte, Andrea R.

2008-01-01

This article provides an overview of current research on Fragile X Syndrome, and how that knowledge can be used to guide successful intervention. The genetic etiology of Fragile X is reviewed and the physical, cognitive, adaptive, behavioral, and emotional phenotypes of children with the disorder are described, highlighting the differences in…

Pediatric Neurodevelopmental Treatment

ERIC Educational Resources Information Center

Camacho, Ricardo; McCauley, Brandon; Szczech Moser, Christy

2016-01-01

Over 70 years ago Dr. Karel Bobath and his wife Bertha Bobath began to craft the therapeutic intervention now known as neurodevelopmental treatment (NDT). This edition of Reviews, Tools, and Resources will highlight a historical review of research studies that have been completed, current websites, books, and blogs focusing on NDT.

60 Years of Great Science (Oak Ridge National Laboratory)

DOE R&D Accomplishments Database

2003-01-01

This issue of Oak Ridge National Laboratory Review (vol. 36, issue 1) highlights Oak Ridge National Laboratory's contributions in more than 30 areas of research and related activities during the past 60 years and provides glimpses of current activities that are carrying on this heritage.

Experiences, attitudes and barriers towards research amongst junior faculty of Pakistani medical universities.

PubMed

Sabzwari, Saniya; Kauser, Samreen; Khuwaja, Ali Khan

2009-11-16

The developing world has had limited quality research and in Pakistan, research is still in its infancy. We conducted a study to assess the proportion of junior faculty involved in research to highlight their attitude towards research, and identify the factors associated with their research involvement. A cross-sectional study was conducted in four medical universities/teaching hospitals in Pakistan, representing private and public sectors. A pre-tested, self-administered questionnaire was used to collect information from 176 junior faculty members of studied universities/hospitals. Logistic regression analysis was used to identify factors related to attitudes and barriers in research among those currently involved in research with those who were not. Overall, 41.5% of study subjects were currently involved in research. A highly significant factor associated with current research involvement was research training during the post-graduate period (p < 0.001). Other factors associated with current involvement in research were male gender, working in the public sector and previous involvement in research. Overall, a large majority (85.2%) of doctors considered research helpful in their profession and had a positive attitude towards research; nevertheless this positive attitude was more frequently reported by doctors who were currently involved in research compared to those who were not (OR = 4.69; 95% CI = 1.54-14.26). Similarly, a large proportion (83.5%) of doctors considered research difficult to conduct; higher by doctors who were not presently involved in research (OR = 2.74; 95% CI = 1.20-6.22) Less than half of the study participants were currently involved in research. Research output may improve if identified barriers are rectified. Further studies are recommended in this area.

Chemically modified graphene based supercapacitors for flexible and miniature devices

NASA Astrophysics Data System (ADS)

Ghosh, Debasis; Kim, Sang Ouk

2015-09-01

Rapid progress in the portable and flexible electronic devises has stimulated supercapacitor research towards the design and fabrication of high performance flexible devices. Recent research efforts for flexible supercapacitor electrode materials are highly focusing on graphene and chemically modified graphene owing to the unique properties, including large surface area, high electrical and thermal conductivity, excellent mechanical flexibility, and outstanding chemical stability. This invited review article highlights current status of the flexible electrode material research based on chemically modified graphene for supercapacitor application. A variety of electrode architectures prepared from chemically modified graphene are summarized in terms of their structural dimensions. Novel prototypes for the supercapacitor aiming at flexible miniature devices, i.e. microsupercapacitor with high energy and power density are highlighted. Future challenges relevant to graphene-based flexible supercapacitors are also suggested. [Figure not available: see fulltext.

What is the need for comparative effectiveness studies in IBD?

PubMed

Flasar, Mark H; Cross, Raymond K

2014-11-01

Unlike traditional clinical trial research, Comparative Effectiveness Research seeks to determine what is 'best' for a typical patient when deciding between effective options used in daily practice - a therapy, diagnostic test, or course of action. There is a clear need for Comparative Effectiveness Research in Inflammatory Bowel Disease, a point emphasized by the Institute of Medicine and supported by governmental agencies and escalating funding. This review highlights the rationale and support for Comparative Effectiveness Research, provides examples of Comparative Effectiveness Research in Inflammatory Bowel Disease, and outlines current and future focus for Comparative Effectiveness Research in Inflammatory Bowel Disease.

The orthopaedic research scene and strategies to improve it.

PubMed

Rankin, K S; Sprowson, A P; McNamara, I; Akiyama, T; Buchbinder, R; Costa, M L; Rasmussen, S; Nathan, S S; Kumta, S; Rangan, A

2014-12-01

Trauma and orthopaedics is the largest of the surgical specialties and yet attracts a disproportionately small fraction of available national and international funding for health research. With the burden of musculoskeletal disease increasing, high-quality research is required to improve the evidence base for orthopaedic practice. Using the current research landscape in the United Kingdom as an example, but also addressing the international perspective, we highlight the issues surrounding poor levels of research funding in trauma and orthopaedics and indicate avenues for improving the impact and success of surgical musculoskeletal research. ©2014 The British Editorial Society of Bone & Joint Surgery.

Review of patents and application of spray drying in pharmaceutical, food and flavor industry.

PubMed

Patel, Bhavesh B; Patel, Jayvadan K; Chakraborty, Subhashis

2014-04-01

Spray drying has always remained an energetic field of innovation in pharmaceutical, food and flavor industry since last couple of decades. The current communication embodies an in-depth application of spray drying in pulmonary drug delivery for production of uniform and respirable size particles suitable for nebulizers, dry powder inhalers (DPI) and pressurized metered dose inhalers (pMDI). The review also highlights spray drying application in the manufacturing of mucoadhesive formulation suitable for nasal cavities to improve the drug absorption and bioavailability. Recent research works and patents filed by various researchers on spray drying technology for solubility enhancement have also been accentuated. Benefits of spray drying in production of dry flavorings to meet a product with maximum yield and least flavor loss are also discussed. The use of spray drying in production of various food products like milk or soymilk powder, tomato pulp, dry fruit juice etc, and in encapsulation of vegetable oil or fish oil and dry creamer has been discussed. Current review also highlights the application of spray drying in the biotechnology field like production of dry influenza or measles vaccine as well as application in ceramic industry. Spray drying based patents issued by the U.S. Patent and Trademark Office in the area of drug delivery have also been included in the current review to emphasize importance of spray drying in the recent research scenario.

Conceptualising Animal Abuse with an Antisocial Behaviour Framework

PubMed Central

Gullone, Eleonora

2011-01-01

Simple Summary There is increasing acceptance of the links between animal abuse and aggressive or antisocial behaviours toward humans. Nevertheless, researchers and other professionals continue to call for methodologically sound empirical research amongst claims that current animal abuse research is methodologically limited. Below, I argue that current conceptualizations of antisocial and aggressive human behavior logically incorporate animal abuse. Given that the body of empirical evidence available to support of theories of antisocial and aggressive behaviour is large and sound, conceptualization of animal abuse as an aggressive behaviour rather than a behaviour that is somehow different, enables us to confidently promote putting current understanding into practice. Abstract This paper reviews current findings in the human aggression and antisocial behaviour literature and those in the animal abuse literature with the aim of highlighting the overlap in conceptualisation. The major aim of this review is to highlight that the co-occurrence between animal abuse behaviours and aggression and violence toward humans can be logically understood through examination of the research evidence for antisocial and aggressive behaviour. From examination through this framework, it is not at all surprising that the two co-occur. Indeed, it would be surprising if they did not. Animal abuse is one expression of antisocial behaviour. What is also known from the extensive antisocial behaviour literature is that antisocial behaviours co-occur such that the presence of one form of antisocial behaviour is highly predictive of the presence of other antisocial behaviours. From such a framework, it becomes evident that animal abuse should be considered an important indicator of antisocial behaviour and violence as are other aggressive and antisocial behaviours. The implications of such a stance are that law enforcement, health and other professionals should not minimize the presence of animal abuse in their law enforcement, prevention, and treatment decisions. PMID:26486220

Launch of Zoological Letters.

PubMed

Fukatsu, Takema; Kuratani, Shigeru

2016-02-01

A new open-access journal, Zoological Letters, was launched as a sister journal to Zoological Science, in January 2015. The new journal aims at publishing topical papers of high quality from a wide range of basic zoological research fields. This review highlights the notable reviews and research articles that have been published in the first year of Zoological Letters, providing an overview on the current achievements and future directions of the journal.

Evolution of Clinical Proteomics and its Role in Medicine | Office of Cancer Clinical Proteomics Research

Cancer.gov

NCI's Office of Cancer Clinical Proteomics Research authored a review of the current state of clinical proteomics in the peer-reviewed Journal of Proteome Research. The review highlights outcomes from the CPTC program and also provides a thorough overview of the different technologies that have pushed the field forward. Additionally, the review provides a vision for moving the field forward through linking advances in genomic and proteomic analysis to develop new, molecularly targeted interventions.

Structural dynamics division research and technology accomplishments for fiscal year 1990 and plans for fiscal year 1991

NASA Technical Reports Server (NTRS)

Wynne, Eleanor C.

1991-01-01

The research accomplishments of the Structural Dynamics Division for F.Y. 1991 are presented. The work is discussed in terms of highlights of accomplishments during the past year and plans for the current year as they relate to 5-year plans and the objectives of each technical area. Included is research on unsteady aerodynamics, helicopter rotors, computational fluid dynamics, oscillations of leading edge flaps of a delta wing, and aircraft wing loads.

Decision Support Methods and Tools

NASA Technical Reports Server (NTRS)

Green, Lawrence L.; Alexandrov, Natalia M.; Brown, Sherilyn A.; Cerro, Jeffrey A.; Gumbert, Clyde r.; Sorokach, Michael R.; Burg, Cecile M.

2006-01-01

This paper is one of a set of papers, developed simultaneously and presented within a single conference session, that are intended to highlight systems analysis and design capabilities within the Systems Analysis and Concepts Directorate (SACD) of the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC). This paper focuses on the specific capabilities of uncertainty/risk analysis, quantification, propagation, decomposition, and management, robust/reliability design methods, and extensions of these capabilities into decision analysis methods within SACD. These disciplines are discussed together herein under the name of Decision Support Methods and Tools. Several examples are discussed which highlight the application of these methods within current or recent aerospace research at the NASA LaRC. Where applicable, commercially available, or government developed software tools are also discussed

Advances in Instrumental Analysis of Brominated Flame Retardants: Current Status and Future Perspectives

PubMed Central

2014-01-01

This review aims to highlight the recent advances and methodological improvements in instrumental techniques applied for the analysis of different brominated flame retardants (BFRs). The literature search strategy was based on the recent analytical reviews published on BFRs. The main selection criteria involved the successful development and application of analytical methods for determination of the target compounds in various environmental matrices. Different factors affecting chromatographic separation and mass spectrometric detection of brominated analytes were evaluated and discussed. Techniques using advanced instrumentation to achieve outstanding results in quantification of different BFRs and their metabolites/degradation products were highlighted. Finally, research gaps in the field of BFR analysis were identified and recommendations for future research were proposed. PMID:27433482

Virtual reality: past, present and future.

PubMed

Gobbetti, E; Scateni, R

1998-01-01

This report provides a short survey of the field of virtual reality, highlighting application domains, technological requirements, and currently available solutions. The report is organized as follows: section 1 presents the background and motivation of virtual environment research and identifies typical application domain, section 2 discusses the characteristics a virtual reality system must have in order to exploit the perceptual and spatial skills of users, section 3 surveys current input/output devices for virtual reality, section 4 surveys current software approaches to support the creation of virtual reality systems, and section 5 summarizes the report.

"Being Good" at Maths: Fabricating Gender Subjectivity

ERIC Educational Resources Information Center

Chronaki, Anna; Pechtelidis, Yannis

2012-01-01

Current research in mathematics education places emphasis on the analysis of men and women's accounts about their life trajectories and choices for studying, working and developing a career that involves the learning and teaching of mathematics. Within this realm, the present study aims to highlight how mathematics, gender and subjectivity become…

NASA Satellite Observations: A Unique Asset for the Study of the Environment and Implications for Public Health

NASA Technical Reports Server (NTRS)

Estes Sue M.

2010-01-01

This slide presentation highlights how satellite observation systems are assets for studying the environment in relation to public health. It includes information on current and future satellite observation systems, NASA's public health and safety research, surveillance projects, and NASA's public health partners.

Anxiety Disorders in Childhood: Casting a Nomological Net

ERIC Educational Resources Information Center

Weems, Carl F.; Stickle, Timothy R.

2005-01-01

Empirical research highlights the need for improving the childhood anxiety disorder diagnostic classification system. In particular, inconsistencies in the stability estimates of childhood anxiety disorders and high rates of comorbidity call into the question the utility of the current "DSM" criteria. This paper makes a case for utilizing a…

NREN for All: Insurmountable Opportunity.

ERIC Educational Resources Information Center

Polly, Jean Armour

1993-01-01

Discussion of the NREN (National Research and Education Network) and issues of access focuses on the role of the public library. Highlights include current uses of the Internet; resource sharing; guidelines for public library service; availability of the Internet and NREN through public libraries; and a sidebar that lists sources of further…

A Meta-Analysis of the Social Communication Questionnaire: Screening for Autism Spectrum Disorder

ERIC Educational Resources Information Center

Chesnut, Steven R.; Wei, Tianlan; Barnard-Brak, Lucy; Richman, David M.

2017-01-01

The current meta-analysis examines the previous research on the utility of the Social Communication Questionnaire as a screening instrument for autism spectrum disorder. Previously published reports have highlighted the inconsistencies between Social Communication Questionnaire-screening results and formal autism spectrum disorder diagnoses. The…

Understanding Immigrants, Schooling, and School Psychology: Contemporary Science and Practice

ERIC Educational Resources Information Center

Frisby, Craig L.; Jimerson, Shane R.

2016-01-01

Immigration into the United States is a particularly salient topic of current contemporary educational, social, and political discussions. The school-related needs of immigrant children and youth can be well served by rigorous research and effective school psychology preservice training and preparation. This overview highlights key definitions,…

Effective Strategies for Teaching in K-8 Classrooms

ERIC Educational Resources Information Center

Moore, Kenneth D.; Hansen, Jacqueline

2011-01-01

Featuring a wealth of reflection activities and connections to standards, this concise, easy-to-read teaching methods text equips students with the content knowledge and skills they need to become effective K-8 teachers. The book maximizes instructional flexibility, reflects current educational issues, highlights recent research, and models best…

A Condition Based Maintenance Approach to Forecasting B-1 Aircraft Parts

DTIC Science & Technology

2017-03-23

1 Problem Statement...aimed at making the USAF aware of CBM methods, and recommending which techniques to consider for implementation. Problem Statement The USAF relies on... problem , this research will seek to highlight common CBM forecasting methods that are well established and evaluate its suitability with current USAF

Human Trafficking: A Review for Mental Health Professionals

ERIC Educational Resources Information Center

Yakushko, Oksana

2009-01-01

This article provides a review of current research on human trafficking for mental health practitioners and scholars. In addition to an overview of definitions, causes and processes of trafficking, the article highlights mental health consequences of trafficking along with suggestions for treatment of survivors. Directions for counseling services,…

Green Roofs: A Part of Green Infrastructure Strategy for Urban Areas

EPA Science Inventory

This is a presentation on the basics of green roof technology. The presentation highlights some of the recent ORD research projects on green roofs and provides insight for the end user as to the benefits for green roof technology. It provides links to currently available EPA rep...

Importance, preservation and management of riparian habitat: A symposium; Tucson, Arizona; July 9, 1977

Treesearch

R. Roy Johnson; Dale A. Jones

1977-01-01

Twelve presented and 15 contributed papers highlight what is known about this unique, diminishing vegetative type: characteristics, classification systems, associated fauna, use conflicts, management alternatives, and research needs. Speakers stressed the continuity and interrelationships of riparian ecosystems, their wildlife and vegetation, historic and current uses...

The College Student and Marijuana: Research Findings Concerning Adverse Biological and Psychological Effects.

ERIC Educational Resources Information Center

Nicholi, Armand M., Jr.

1983-01-01

This paper focuses on current knowledge about adverse biological and psychological affects of marijuana use, with special reference to risks for college students. Short-term effects on intellectual functioning and perceptual-motor coordination and long-term effects on reproduction and motivation are highlighted. (PP)

It's Not Your Mother's Home Economics.

ERIC Educational Resources Information Center

Schneider, Alison

2000-01-01

Reports on the great range of scholarship and activities engaged in by modern home economists and contrasts these with persistent stereotypes of the field as lacking intellectual rigor, all female, and socially conservative. Reviews the history of the field and highlights current research and other activities at Cornell University's College of…

Understanding, Evaluating, and Supporting Self-Regulated Learning Using Learning Analytics

ERIC Educational Resources Information Center

Roll, Ido; Winne, Philip H.

2015-01-01

Self-regulated learning is an ongoing process rather than a single snapshot in time. Naturally, the field of learning analytics, focusing on interactions and learning trajectories, offers exciting opportunities for analyzing and supporting self-regulated learning. This special section highlights the current state of research at the intersection of…

African swine fever virus: current state and future perspectives in vaccine and antiviral research.

PubMed

Zakaryan, Hovakim; Revilla, Yolanda

2016-03-15

African swine fever (ASF) is among the most significant of swine diseases for which no effective vaccines and antivirals are available. The disease, which is endemic in Africa, was introduced to Trans-Caucasian countries and the Russian Federation in 2007, where it remains prevalent today among domestic pigs and wild boars. Although some measures were implemented, ASF continues to pose a global risk for all countries, and thereby highlighting the importance of vaccine and antiviral research. In this review, an overview of research efforts toward the development of effective vaccines during the past decades is presented. As an alternative to vaccine development, the current state in antiviral research against ASFV is also presented. Finally, future perspectives in vaccine and antiviral research giving emphasis on some strategies that may allow researchers to develop effective countermeasures against ASF are discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Basic science research in urology training.

PubMed

Eberli, D; Atala, A

2009-04-01

The role of basic science exposure during urology training is a timely topic that is relevant to urologic health and to the training of new physician scientists. Today, researchers are needed for the advancement of this specialty, and involvement in basic research will foster understanding of basic scientific concepts and the development of critical thinking skills, which will, in turn, improve clinical performance. If research education is not included in urology training, future urologists may not be as likely to contribute to scientific discoveries.Currently, only a minority of urologists in training are currently exposed to significant research experience. In addition, the number of physician-scientists in urology has been decreasing over the last two decades, as fewer physicians are willing to undertake a career in academics and perform basic research. However, to ensure that the field of urology is driving forward and bringing novel techniques to patients, it is clear that more research-trained urologists are needed. In this article we will analyse the current status of basic research in urology training and discuss the importance of and obstacles to successful addition of research into the medical training curricula. Further, we will highlight different opportunities for trainees to obtain significant research exposure in urology.

Economic Measures of Pollination Services: Shortcomings and Future Directions.

PubMed

Breeze, Tom D; Gallai, Nicola; Garibaldi, Lucas A; Li, Xui S

2016-12-01

Over the past 20 years, there has been growing interest in the possible economic impacts of pollination service loss and management. Although the literature area has expanded rapidly, there remains ongoing debate about the usefulness of such exercises. Reviewing the methods and findings of the current body of literature, this review highlights three major trends: (i) estimated benefits are heterogeneous, even when using the same method, due to several often-neglected factors. (ii) The current body of literature focuses heavily on the developed world, neglecting the effects on developing countries. (iii) Very few studies are suitable for informing management and policy. The review highlights the need for fully interdisciplinary work that embeds stakeholders and economic impacts into primary ecological research. Copyright © 2016 Elsevier Ltd. All rights reserved.

Family wellbeing of individuals with autism spectrum disorder: A scoping review.

PubMed

Tint, Ami; Weiss, Jonathan A

2016-04-01

Families play an important role in supporting individuals with autism spectrum disorder across the lifespan. Indicators of family wellbeing can help to establish benchmarks for service provision and evaluation; however, a critical first step is a clear understanding of the construct in question. The purpose of the current scoping review was to (a) summarize current conceptualizations and measurements of family wellbeing, (b) synthesize key findings, and (c) highlight gaps and limitations in the extant literature. A final review of 86 articles highlighted the difficulty of synthesizing findings of family wellbeing in the autism spectrum disorder literature due to varied measurement techniques and the limited use of a common theoretical direction. Considerations for future research are presented with an eye toward policy relevance. © The Author(s) 2015.

The current state of the art of quantitative phosphoproteomics and its applications to diabetes research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, Chi Yuet X’avia; Gritsenko, Marina A.; Smith, Richard D.

Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been revealed in various human diseases. Kinases and their cognate inhibitors have been hotspot for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for the disease of interest. In this review, we will highlight recent advances in phosphoproteomics, the current state-of-the-art of the technologies, and the challenges and future perspectives of this research area. Finally, we will underscore some exemplary applications of phosphoproteomicsmore » in diabetes research.« less

Windows on the Human Body – in Vivo High-Field Magnetic Resonance Research and Applications in Medicine and Psychology

PubMed Central

Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph. S.; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

2010-01-01

Analogous to the evolution of biological sensor-systems, the progress in “medical sensor-systems”, i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given. PMID:22219684

Fundamentals and Application of Magnetic Particles in Cell Isolation and Enrichment

PubMed Central

Plouffe, Brian D.; Murthy, Shashi K.; Lewis, Laura H.

2014-01-01

Magnetic sorting using magnetic beads has become a routine methodology for the separation of key cell populations from biological suspensions. Due to the inherent ability of magnets to provide forces at a distance, magnetic cell manipulation is now a standardized process step in numerous processes in tissue engineering, medicine, and in fundamental biological research. Herein we review the current status of magnetic particles to enable isolation and separation of cells, with a strong focus on the fundamental governing physical phenomena, properties and syntheses of magnetic particles and on current applications of magnet-based cell separation in laboratory and clinical settings. We highlight the contribution of cell separation to biomedical research and medicine and detail modern cell separation methods (both magnetic and non-magnetic). In addition to a review of the current state-of-the-art in magnet-based cell sorting, we discuss current challenges and available opportunities for further research, development and commercialization of magnetic particle-based cell separation systems. PMID:25471081

Testing technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-10-01

This bulletin from Sandia National Laboratories presents current research highlights in testing technology. Ion microscopy offers new nondestructive testing technique that detects high resolution invisible defects. An inexpensive thin-film gauge checks detonators on centrifuge. Laser trackers ride the range and track helicopters at low-level flights that could not be detected by radar. Radiation transport software predicts electron/photon effects via cascade simulation. Acoustic research in noise abatement will lead to quieter travelling for Bay Area Rapid Transport (BART) commuters.

Career and Technical Education Reforms and Comprehensive School Reforms in High Schools: Their Impact on Education Outcomes for At-Risk Youth. The Highlight Zone: Research @ Work.

ERIC Educational Resources Information Center

Castellano, Marisa; Stringfield, Samuel; Stone, James R., III

The impact of career and technical education (CTE) reforms and comprehensive school reforms in high schools on education outcomes for at-risk youth was examined in a review of research on current reforms. The review identified a series of individual, family and home, school, and community factors that can place students at risk of failing to…

Forum on Emerging Infectious Diseases Highlights Leading-Edge Research | Poster

Cancer.gov

Scientists and professionals from multiple governmental agencies recently gathered at NCI at Frederick for a forum on newly emerging infectious diseases, threats to public health, and ongoing efforts to study high-risk pathogens. During the one-day event, which was sponsored by the National Interagency Confederation for Biological Research’s Scientific Interaction Subcommittee, nine speakers from four agencies shared their research and their agencies’ endeavors to address current and future biological threats.

Current and future directions in culture and happiness research.

PubMed

Oishi, Shigehiro; Gilbert, Elizabeth A

2016-04-01

Once believed to be universal, a growing body of research shows that both the conception and predictors of happiness vary cross-culturally. First, the meaning and importance of happiness varies both across time and between nations. Americans, for instance, tend to define happiness in terms of pleasure or enjoyment and view happiness as universally positive, whereas East Asian and Middle Eastern cultures may highlight the transient and socially disruptive nature of happiness and be ambivalent about whether it is good. Second, predictors of happiness vary between cultures. Recent work highlights new mediators (e.g., relational mobility), individual predictors (e.g., person-culture fit), societal factors (e.g., good governance and wealth), within-culture variations (e.g., at the state or city level), and interventions (e.g., practicing gratitude) that differ cross-culturally or help explain cultural differences in happiness. Though many questions remain, this review highlights how these recent advances broaden and revise our understanding of culture and happiness. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dating violence among college students: the risk and protective factors.

PubMed

Kaukinen, Catherine

2014-10-01

The research review synthesizes the knowledge base on risk and protective factors for dating violence while highlighting its relevance to violence against college women. In particular, the review highlights the personal, family, relationship, and behavioral factors that heighten the risk of dating violence victimization and perpetration while also noting the methodological limitations of the current body of empirical research and identifying directions for future academic work. Researchers have identified the correlation between risky health and behavioral factors and dating violence, most often modeling these as part of the etiology of dating violence among college students. Less often have scholars explored these as co-occurring risk factors. This approach to dating violence may be used to develop meaningful and impactful interventions to reduce the incidence and prevalence of college dating violence while also addressing the other health risk behaviors that impact academic success and place students' well-being at risk. © The Author(s) 2014.

Emerging issues in public health genomics

PubMed Central

Roberts, J. Scott

2014-01-01

This review highlights emerging areas of interest in public health genomics. First, recent advances in newborn screening (NBS) are described, with a focus on practice and policy implications of current and future efforts to expand NBS programs (e.g., via next-generation sequencing). Next, research findings from the rapidly progressing field of epigenetics and epigenomics are detailed, highlighting ways in which our emerging understanding in these areas could guide future intervention and research efforts in public health. We close by considering various ethical, legal and social issues posed by recent developments in public health genomics; these include policies to regulate access to personal genomic information; the need to enhance genetic literacy in both health professionals and the public; and challenges in ensuring that the benefits (and burdens) from genomic discoveries and applications are equitably distributed. Needs for future genomics research that integrates across basic and social sciences are also noted. PMID:25184533

Language Measurement Equivalence of the Ethnic Identity Scale With Mexican American Early Adolescents

PubMed Central

White, Rebecca M. B.; Umaña-Taylor, Adriana J.; Knight, George P.; Zeiders, Katharine H.

2011-01-01

The current study considers methodological challenges in developmental research with linguistically diverse samples of young adolescents. By empirically examining the cross-language measurement equivalence of a measure assessing three components of ethnic identity development (i.e., exploration, resolution, and affirmation) among Mexican American adolescents, the study both assesses the cross-language measurement equivalence of a common measure of ethnic identity and provides an appropriate conceptual and analytical model for researchers needing to evaluate measurement scales translated into multiple languages. Participants are 678 Mexican-origin early adolescents and their mothers. Measures of exploration and resolution achieve the highest levels of equivalence across language versions. The measure of affirmation achieves high levels of equivalence. Results highlight potential ways to correct for any problems of nonequivalence across language versions of the affirmation measure. Suggestions are made for how researchers working with linguistically diverse samples can use the highlighted techniques to evaluate their own translated measures. PMID:22116736

Emerging issue of e-waste in Pakistan: A review of status, research needs and data gaps.

PubMed

Iqbal, Mehreen; Breivik, Knut; Syed, Jabir Hussain; Malik, Riffat Naseem; Li, Jun; Zhang, Gan; Jones, Kevin C

2015-12-01

This review article focuses on the current situation of e-waste in Pakistan with the emphasis on defining the major e-waste recycling sites, current and future domestic generation of e-waste, hidden flows or import of e-waste and discusses various challenges for e-waste management. Needed policy interventions and possible measures to be taken at governmental level are discussed to avoid the increasing problem of e-waste in the country. Our findings highlight that there is still a general lack of reliable data, inventories and research studies addressing e-waste related issues in the context of environmental and human health in Pakistan. There is therefore a critical need to improve the current knowledge base, which should build upon the research experience from other countries which have experienced similar situations in the past. Further research into these issues in Pakistan is considered vital to help inform future policies/control strategies as already successfully implemented in other countries. Copyright © 2015 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kabisch, Nadja, E-mail: nadja.kabisch@geo.hu-berlin.de; Department of Urban and Environmental Sociology, Helmholtz Centre for Environmental Research — UFZ, 04318 Leipzig; Qureshi, Salman

Scientific papers on landscape planning underline the importance of maintaining and developing green spaces because of their multiple environmental and social benefits for city residents. However, a general understanding of contemporary human–environment interaction issues in urban green space is still incomplete and lacks orientation for urban planners. This review examines 219 publications to (1) provide an overview of the current state of research on the relationship between humans and urban green space, (2) group the different research approaches by identifying the main research areas, methods, and target groups, and (3) highlight important future prospects in urban green space research. -more » Highlights: • Reviewed literature on urban green pins down a dearth of comparative studies. • Case studies in Africa and Russia are marginalized – the Europe and US dominate. • Questionnaires are used as major tool followed by GIS and quantitative approaches. • Developing countries should contribute in building an urban green space agenda. • Interdisciplinary, adaptable and pluralistic approaches can satiate a knowledge gap.« less

What research tells us about knowledge transfer strategies to improve public health in low-income countries: a scoping review.

PubMed

Siron, Stéphanie; Dagenais, Christian; Ridde, Valéry

2015-11-01

This study describes the current state of research on knowledge transfer strategies to improve public health in low-income countries, to identify the knowledge gaps on this topic. In this scoping review, a descriptive and systematic process was used to analyse, for each article retained, descriptions of research context and methods, types of knowledge transfer activities and results reported. 28 articles were analysed. They dealt with the evaluation of transfer strategies that employed multiple activities, mostly targeting health professionals and women with very young children. Most often these studies used quantitative designs and measurements of instrumental use with some methodological shortcomings. Results were positive and suggested recommendations for improving professional practices, knowledge and health-related behaviours. The review highlights the great diversity of transfer strategies used, strategies and many conditions for knowledge use. The review provides specific elements for understanding the transfer processes in low-income countries and highlights the need for systematic evaluation of the conditions for research results utilization.

Navigating translational ecology: Creating opportunities and overcoming obstacles for scientist participation

NASA Astrophysics Data System (ADS)

Morelli, T. L.; Hallett, L. M.; Gerber, L. R.; Moritz, M.; Schwartz, M.; Stephenson, N.; Tank, J. L.; Williamson, M. A.; Woodhouse, C. A.

2016-12-01

As scientists seek to make their research more relevant and impactful, a growing number are interested in translational approaches that yield scientific and applied outcomes through iterative collaboration between scientists and practitioners. This is particularly true in the field of ecology, where many of its experts are interested in the resource management and conservation implications of their research. Unfortunately, the pathways to translational ecology are not always apparent. Here we will outline a set of principles to guide academic scientists in the process of translational ecology and provide concrete examples of novel outcomes. We will highlight structural aspects of collaborations, such as how to initiate and sustain projects in ways that meet the needs of all participants. We will also outline common pitfalls for scientists and practitioners, and ways in which translational research can help overcome them. Throughout we will use pressing environmental challenges to emphasize opportunities that exist within current institutional frameworks, while also highlighting ways in which institutions are changing to facilitate effective translational research.

Educational Research--History of Education a Curious Case?

ERIC Educational Resources Information Center

Goodman, Joyce; Grosvenor, Ian

2009-01-01

The article begins with an exploration of the current state of history of education by drawing on published reviews of history of education, thematic analysis of journal content, and mapping of postgraduate study. It then highlights "moments of insecurity". These are characterised by a particular discourse that frames the future of the discipline…

Exemplary Instruction in the Middle Grades: Teaching That Supports Engagement and Rigorous Learning

ERIC Educational Resources Information Center

Lapp, Diane, Ed.; Moss, Barbara, Ed.

2011-01-01

Offering fresh alternatives to common instructional practices that fail to get results, this accessible, highly practical guide highlights ways to motivate middle school students while enhancing content-area learning. Each chapter features an enlightening case study of a teacher whose current strategies are not supported by research; describes…

Neurobiological Underpinnings of Math and Reading Learning Disabilities

ERIC Educational Resources Information Center

Ashkenazi, Sarit; Black, Jessica M.; Abrams, Daniel A.; Hoeft, Fumiko; Menon, Vinod

2013-01-01

The primary goal of this review is to highlight current research and theories describing the neurobiological basis of math (MD), reading (RD), and comorbid math and reading disability (MD+RD). We first describe the unique brain and cognitive processes involved in acquisition of math and reading skills, emphasizing similarities and differences in…

Long-Range Planning for Texas Higher Education.

ERIC Educational Resources Information Center

Texas Higher Education Coordinating Board, Austin.

The report presents results of the first year's effort in developing a master plan for higher education in Texas. The first section highlights contributions of Texas higher education in the areas of research, public service, and teaching. Examined in the next section is the current higher education setting with data on the present status of Texas…

Mission Information and Test Systems Summary of Accomplishments, 2012-2013

NASA Technical Reports Server (NTRS)

McMorrow, Sean; Sherrard, Roberta; Gibbs, Yvonne

2015-01-01

This annual report covers the activities of the NASA Dryden Flight Research Center's Mission Information and Test Systems directorate, which include the Western Aeronautical Test Range (Range Engineering and Range Operations), the Simulation Engineering Branch, and Information Services. This report contains highlights, current projects, and various awards achieved throughout 2012 and 2013.

Perfectionism in Language Learners: Review, Conceptualization, and Recommendations for Teachers and School Psychologists

ERIC Educational Resources Information Center

Flett, Gordon L.; Hewitt, Paul L.; Su, Chang; Flett, Kathleen D.

2016-01-01

The pressures inherent in trying to be perfect can undermine learning and exacerbate anxiety in certain students. In the current article, we review existing research and theory on the role of perfectionism in language learning anxiety and performance deficits. Our analysis highlights the complexities inherent in the perfectionism construct,…

From Early to Current Developments in Online Learning at Nova Southeastern University: Reflections on Historical Milestones.

ERIC Educational Resources Information Center

Dringus, Laurie P.; Scigliano, John A.

2000-01-01

Traces the major historical milestones achieved by Nova Southeastern University in its pioneering of graduate level online learning programs. Highlights include delivery systems; Web-based electronic classrooms; overview of the technology, including telecommunications through UNIX; evaluation and research; and technology used in the School of…

Social Studies--The Next Generation: Re-Searching in the Postmodern. Counterpoints, Studies in the Postmodern Theory of Education Volume 272

ERIC Educational Resources Information Center

Segall, Avner, Ed.; Heilman, Elizabeth E., Ed.; Cherryholmes, Cleo H., Ed.

2006-01-01

This book broadens the imagination within social studies education by highlighting current, cutting-edge scholarship incorporating critical discourses. Drawing on postmodern, poststructural, postcolonial, and feminist theories often borrowed from cultural studies, curriculum theory, critical geography, women's studies, and queer studies, the…

Enhancing Secondary Science Content Accessibility with Video Games

ERIC Educational Resources Information Center

Marino, Matthew T.; Becht, Kathleen M.; Vasquez, Eleazar, III; Gallup, Jennifer L.; Basham, James D.; Gallegos, Benjamin

2014-01-01

Mobile devices, including iPads, tablets, and so on, are common in high schools across the country. Unfortunately, many secondary teachers see these devices as distractions rather than tools for scaffolding instruction. This article highlights current research related to the use of video games as a means to increase the cognitive and social…

Subterranean ventilation of allochthonous CO2 governs net CO2 exchange in a semiarid Mediterranean grassland

USDA-ARS?s Scientific Manuscript database

Recent research highlights the important role of (semi-) arid ecosystems in the global carbon (C) cycle. However, detailed process based investigations are still necessary in order to fully understand how drylands behave and to determine the main factors currently affecting their C balance with the ...

Computer science, artificial intelligence, and cybernetics: Applied artificial intelligence in Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubinger, B.

1988-01-01

This sourcebook provides information on the developments in artificial intelligence originating in Japan. Spanning such innovations as software productivity, natural language processing, CAD, and parallel inference machines, this volume lists leading organizations conducting research or implementing AI systems, describes AI applications being pursued, illustrates current results achieved, and highlights sources reporting progress.

What We Don't Know.

ERIC Educational Resources Information Center

Hazen, Robert M.

1997-01-01

Highlights the unanswered questions of science. Summarizes current leading research that demonstrates that those questions are inherently limited in scope, and the chain of discovery and human curiosity that drives the quest for knowledge shows not the slightest sign of ending. Argues that we have yet to recognize and ask many of the most profound…

Constructing Media Artifacts in a Social Constructivist Environment to Enhance Students' Environmental Awareness and Activism

ERIC Educational Resources Information Center

Karahan, Engin; Roehrig, Gillian

2015-01-01

Current science education reforms and policy documents highlight the importance of environmental awareness and perceived need for activism. As "environmental problems are socially constructed in terms of their conceptualized effects on individuals, groups, other living things and systems research based on constructivist principles provides…

Motivation Matters in Mobile Language Learning: A Brief Commentary

ERIC Educational Resources Information Center

Ushioda, Ema

2013-01-01

As highlighted in the original call for papers for this special issue, learning with mobile technologies is currently a rapidly developing area of interest for researchers, teachers, materials writers and app developers in the educational field, not least within language education. Yet to what extent is this growing interest realised and shared by…

Peer Victimization and Adolescent Adjustment: Does School Belonging Matter?

ERIC Educational Resources Information Center

Wormington, Stephanie V.; Anderson, Kristen G.; Schneider, Ashley; Tomlinson, Kristin L.; Brown, Sandra A.

2016-01-01

Recent research highlights the role of peer victimization in students' adjustment across a variety of domains (e.g., academic, social), but less often identifies potential mediating variables. In the current study, we tested for direct effects from peer victimization to adolescents' academic behavior and alcohol use, as well as indirect effects…

Goals, History and Current Programs of Workshop

NASA Technical Reports Server (NTRS)

2001-01-01

Mr. Robert Fusaro, coordinator for the Glenn Research Center Space Mechanisms program, presented the goals of the workshop, history of previous workshops and gave an overview of current space mechanisms work performed by Glenn Research Center. Highlights of his presentation are shown. Following the presentation, Mr. Fusaro demonstrated the new NASA Space Mechanisms Handbook and Reference Guide CD ROM, which was featured as a highlight of the workshop. The handbook is an authoritative guide for design and testing of space mechanisms and related components. Over 600 pages of guidelines written by 25 experts in the field provide in-depth information on how to design space mechanisms and components, including: deployables, release devices, latches, rotating and pointing mechanisms, dampers, motors, gears, fasteners, valves, etc. The handbook provides details on appropriate environmental and tribological testing methods and practices required to evaluate new mechanisms and components. Distribution of the Handbook and Reference Guide is limited by ITAR (International Traffic in Arms Regulations). It is available only to US companies and citizens. A request form for the CD ROM can be found on the Space Mechanisms Project website at http://www.grc.nasa.gov/WWW/spacemech/.

Native America: American Indian Geoscientists & Earth System Science Leaders

NASA Astrophysics Data System (ADS)

Bolman, J. R.

2011-12-01

We are living in a definite time of change. Distinct changes are being experienced in our most sacred and natural environments. This is especially true on Native lands across the Americas. Native people have lived for millennia in distinct and unique ways. The knowledge of balancing the needs of people with the needs of our natural environments is paramount in all Tribal societies. These changes have accelerated the momentum to ensure the future of American Indian Geoscientists and Earth Systems Science Leaders. The presentation will bring to prominence the unique recruitment and mentoring necessary to achieve success that emerged through working with Tribal people. The presentation will highlight: 1) past and present philosophies on recruitment and mentoring of Native/Tribal students in geoscience and earth systems science; 2) current Native leadership and research development; 3) unique collaborations "bridging" Native people across geographic areas (International) in developing educational/research experiences which integrate the distinctive geoscience and earth systems science knowledge of Tribal peoples throughout the Americas. The presentation will highlight currently funded projects and initiatives as well as success stories of emerging Native geoscientists and earth systems science leaders.

Review of spectral imaging technology in biomedical engineering: achievements and challenges.

PubMed

Li, Qingli; He, Xiaofu; Wang, Yiting; Liu, Hongying; Xu, Dongrong; Guo, Fangmin

2013-10-01

Spectral imaging is a technology that integrates conventional imaging and spectroscopy to get both spatial and spectral information from an object. Although this technology was originally developed for remote sensing, it has been extended to the biomedical engineering field as a powerful analytical tool for biological and biomedical research. This review introduces the basics of spectral imaging, imaging methods, current equipment, and recent advances in biomedical applications. The performance and analytical capabilities of spectral imaging systems for biological and biomedical imaging are discussed. In particular, the current achievements and limitations of this technology in biomedical engineering are presented. The benefits and development trends of biomedical spectral imaging are highlighted to provide the reader with an insight into the current technological advances and its potential for biomedical research.

Science for a wilder Anthropocene: Synthesis and future directions for trophic rewilding research.

PubMed

Svenning, Jens-Christian; Pedersen, Pil B M; Donlan, C Josh; Ejrnæs, Rasmus; Faurby, Søren; Galetti, Mauro; Hansen, Dennis M; Sandel, Brody; Sandom, Christopher J; Terborgh, John W; Vera, Frans W M

2016-01-26

Trophic rewilding is an ecological restoration strategy that uses species introductions to restore top-down trophic interactions and associated trophic cascades to promote self-regulating biodiverse ecosystems. Given the importance of large animals in trophic cascades and their widespread losses and resulting trophic downgrading, it often focuses on restoring functional megafaunas. Trophic rewilding is increasingly being implemented for conservation, but remains controversial. Here, we provide a synthesis of its current scientific basis, highlighting trophic cascades as the key conceptual framework, discussing the main lessons learned from ongoing rewilding projects, systematically reviewing the current literature, and highlighting unintentional rewilding and spontaneous wildlife comebacks as underused sources of information. Together, these lines of evidence show that trophic cascades may be restored via species reintroductions and ecological replacements. It is clear, however, that megafauna effects may be affected by poorly understood trophic complexity effects and interactions with landscape settings, human activities, and other factors. Unfortunately, empirical research on trophic rewilding is still rare, fragmented, and geographically biased, with the literature dominated by essays and opinion pieces. We highlight the need for applied programs to include hypothesis testing and science-based monitoring, and outline priorities for future research, notably assessing the role of trophic complexity, interplay with landscape settings, land use, and climate change, as well as developing the global scope for rewilding and tools to optimize benefits and reduce human-wildlife conflicts. Finally, we recommend developing a decision framework for species selection, building on functional and phylogenetic information and with attention to the potential contribution from synthetic biology.

Science for a wilder Anthropocene: Synthesis and future directions for trophic rewilding research

PubMed Central

Svenning, Jens-Christian; Pedersen, Pil B. M.; Donlan, C. Josh; Ejrnæs, Rasmus; Faurby, Søren; Galetti, Mauro; Hansen, Dennis M.; Sandel, Brody; Sandom, Christopher J.; Terborgh, John W.; Vera, Frans W. M.

2016-01-01

Trophic rewilding is an ecological restoration strategy that uses species introductions to restore top-down trophic interactions and associated trophic cascades to promote self-regulating biodiverse ecosystems. Given the importance of large animals in trophic cascades and their widespread losses and resulting trophic downgrading, it often focuses on restoring functional megafaunas. Trophic rewilding is increasingly being implemented for conservation, but remains controversial. Here, we provide a synthesis of its current scientific basis, highlighting trophic cascades as the key conceptual framework, discussing the main lessons learned from ongoing rewilding projects, systematically reviewing the current literature, and highlighting unintentional rewilding and spontaneous wildlife comebacks as underused sources of information. Together, these lines of evidence show that trophic cascades may be restored via species reintroductions and ecological replacements. It is clear, however, that megafauna effects may be affected by poorly understood trophic complexity effects and interactions with landscape settings, human activities, and other factors. Unfortunately, empirical research on trophic rewilding is still rare, fragmented, and geographically biased, with the literature dominated by essays and opinion pieces. We highlight the need for applied programs to include hypothesis testing and science-based monitoring, and outline priorities for future research, notably assessing the role of trophic complexity, interplay with landscape settings, land use, and climate change, as well as developing the global scope for rewilding and tools to optimize benefits and reduce human–wildlife conflicts. Finally, we recommend developing a decision framework for species selection, building on functional and phylogenetic information and with attention to the potential contribution from synthetic biology. PMID:26504218

A Health Economics Response to the Review of the Liverpool Care Pathway

PubMed Central

Coast, Joanna

2013-01-01

Abstract Background: In 2011 the Palliative Care Funding Review highlighted concerns about the funding, provision, and quality of care at the end of life. Two years on, an independent review of the Liverpool Care Pathway—prompted by a storm of negative media coverage— has raised concerns around a lack of funding, availability of support for the dying and their relatives, and patient centered care. There are recommendations to increase funding through a national tariff for palliative care services, address inconsistencies, and replace the Liverpool Care Pathway with individual end-of-life care plans. Objective: This paper explores the economic implications of the review's recommendations and links these to inadequacies with the current economic framework currently recommended for use in the United Kingdom by the National Institute for Health and Care Excellence, before highlighting aspects of ongoing research aimed at addressing these inadequacies. Methods: As well as the published report More Care, Less Pathway, we draw upon preliminary qualitative evidence from 19 semistructured interviews conducted with academics specializing in economics and/or end-of-life care. Conclusions: While there is a need for increased funding in the short term (highlighted in recent reviews), increasing funding to services that have little evidence base appears to be an irresponsible long-term strategy. Hence there should also be increased investment in research and increased emphasis in particular on developing economic tools to evaluate services. PMID:24199790

Current Issues in the Diagnosis of Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder, and Conduct Disorder

PubMed Central

Frick, Paul J.; Nigg, Joel T.

2015-01-01

This review evaluates the diagnostic criteria for three of the most common disorders for which children and adolescents are referred for mental health treatment: attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Although research supports the validity and clinical utility of these disorders, several issues are highlighted that could enhance the current diagnostic criteria. For ADHD, defining the core features of the disorder and its fit with other disorders, enhancing the validity of the criteria through the lifespan, considering alternative ways to form subtypes of the disorder, and modifying the age-of-onset criterion are discussed relative to the current diagnostic criteria. For ODD, eliminating the exclusionary criteria of CD, recognizing important symptom domains within the disorder, and using the cross-situational pervasiveness of the disorder as an index of severity are highlighted as important issues for improving classification. Finally, for CD, enhancing the current subtypes related to age of onset and integrating callous-unemotional traits into the diagnostic criteria are identified as key issues for improving classification. PMID:22035245

Genetic toxicology in the 21st century: Reflections and future ...

EPA Pesticide Factsheets

A symposium at the 40th anniversary of the Environmental Mutagen Society, held from October 24–28, 2009 in St. Louis, MO, surveyed the current status and future directions of genetic toxicology. This article summarizes the presentations and provides a perspective on the future. An abbreviated history is presented, highlighting the current standard battery of genotoxicity assays and persistent challenges. Application of computational toxicology to safety testing within a regulatory setting is discussed as a means for reducing the need for animal testing and human clinical trials, and current approaches and applications of in silico genotoxicity screening approaches across the pharmaceutical industry were surveyed and are reported here. The expanded use of toxicogenomics to illuminate mechanisms and bridge genotoxicity and carcinogenicity, and new public efforts to use high-throughput screening technologies to address lack of toxicity evaluation for the backlog of thousands of industrial chemicals in the environment are detailed. The Tox21 project involves coordinated efforts of four U.S. Government regulatory/research entities to use new and innovative assays to characterize key steps in toxicity pathways, including genotoxic and nongenotoxic mechanisms for carcinogenesis. Progress to date, highlighting preliminary test results from the National Toxicology Program is summarized. Finally, an overview is presented of ToxCast™, a related research program of the

Developing the mental health workforce: review and application of training approaches from multiple disciplines.

PubMed

Lyon, Aaron R; Stirman, Shannon Wiltsey; Kerns, Suzanne E U; Bruns, Eric J

2011-07-01

Strategies specifically designed to facilitate the training of mental health practitioners in evidence-based practices (EBPs) have lagged behind the development of the interventions themselves. The current paper draws from an interdisciplinary literature (including medical training, adult education, and teacher training) to identify useful training and support approaches as well as important conceptual frameworks that may be applied to training in mental health. Theory and research findings are reviewed, which highlight the importance of continued consultation/support following training workshops, congruence between the training content and practitioner experience, and focus on motivational issues. In addition, six individual approaches are presented with careful attention to their empirical foundations and potential applications. Common techniques are highlighted and applications and future directions for mental health workforce training and research are discussed.

70 Years of Aeropropulsion Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Reddy, Dhanireddy R.

2013-01-01

This paper presents a brief overview of air-breathing propulsion research conducted at the NASA Glenn Research Center (GRC) over the past 70 years. It includes a historical perspective of the center and its various stages of propulsion research in response to the countrys different periods of crises and growth opportunities. GRCs research and technology development covered a broad spectrum, from a short-term focus on improving the energy efficiency of aircraft engines to advancing the frontier technologies of high-speed aviation in the supersonic and hypersonic speed regimes. This paper highlights major research programs, showing their impact on industry and aircraft propulsion, and briefly discusses current research programs and future aeropropulsion technology trends in related areas

Creating and sustaining disadvantage: the relevance of a social exclusion framework.

PubMed

Grenier, Amanda M; Guberman, Nancy

2009-03-01

Over the last decade, public home-care services for elderly people have been subject to increased rationing and changes in resource allocation. We argue that a social exclusion framework can be used to explain the impacts of current policy priorities and organisational practices. In this paper, we use the framework of social exclusion to highlight the disadvantages experienced by elderly people, particularly those who cannot afford to supplement public care with private services. We illustrate our argument by drawing on examples from previous studies with persons giving and receiving care in the province of Québec. Our focus is on seven forms of exclusion: symbolic, identity, socio-political, institutional, economic, exclusion from meaningful relations, and territorial exclusion. These illustrations suggest that policy-makers, practitioners and researchers must address the various ways in which current policy priorities can create and sustain various types of exclusion of elderly people. They also highlight the need to reconsider the current decisions made regarding the allocation of services for elderly people.

Plant xylem hydraulics: What we understand, current research, and future challenges.

PubMed

Venturas, Martin D; Sperry, John S; Hacke, Uwe G

2017-06-01

Herein we review the current state-of-the-art of plant hydraulics in the context of plant physiology, ecology, and evolution, focusing on current and future research opportunities. We explain the physics of water transport in plants and the limits of this transport system, highlighting the relationships between xylem structure and function. We describe the great variety of techniques existing for evaluating xylem resistance to cavitation. We address several methodological issues and their connection with current debates on conduit refilling and exponentially shaped vulnerability curves. We analyze the trade-offs existing between water transport safety and efficiency. We also stress how little information is available on molecular biology of cavitation and the potential role of aquaporins in conduit refilling. Finally, we draw attention to how plant hydraulic traits can be used for modeling stomatal responses to environmental variables and climate change, including drought mortality. © 2017 Institute of Botany, Chinese Academy of Sciences.

Developing International Collaborations for Early Career Researchers in Psychology

PubMed Central

Flanagan, Julianne C.; Barrett, Emma L.; Crome, Erica; Forbes, Miriam

2015-01-01

International collaboration is becoming increasingly vital as the emphasis on unmet need for mental health across cultures and nations grows. Opportunities exist for early career researchers to engage in international collaboration. However, little information is provided about such opportunities in most current psychology training models. The authors are early career researchers in psychology from U.S. and Australia who have developed a collaborative relationship over the past two years. Our goal is to increase awareness of funding opportunities to support international research and to highlight the benefits and challenges associated with international collaboration based on our experience. PMID:27453624

NASA Applications of Structural Health Monitoring Technology

NASA Technical Reports Server (NTRS)

Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

2013-01-01

This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, International Space Station, Uninhabited Aerial Vehicles, and Expandable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

NASA Applications of Structural Health Monitoring Technology

NASA Technical Reports Server (NTRS)

Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

2013-01-01

This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, the International Space Station, Uninhabited Aerial Vehicles, and Expendable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

Molecular mechanism-based model to enhance outcomes of dietary intervention studies for disease prevention

PubMed Central

Dey, Moul

2014-01-01

Advances in “omics”-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and “omics”-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study systems is one of the many roadblocks faced by translational research today. This commentary will highlight the current status of such research, particularly emphasizing the role of nutrigenomics. PMID:25364700

A Perspective on DNA Microarrays in Pathology Research and Practice

PubMed Central

Pollack, Jonathan R.

2007-01-01

DNA microarray technology matured in the mid-1990s, and the past decade has witnessed a tremendous growth in its application. DNA microarrays have provided powerful tools for pathology researchers seeking to describe, classify, and understand human disease. There has also been great expectation that the technology would advance the practice of pathology. This review highlights some of the key contributions of DNA microarrays to experimental pathology, focusing in the area of cancer research. Also discussed are some of the current challenges in translating utility to clinical practice. PMID:17600117

[Mixed methods research in public health: issues and illustration].

PubMed

Guével, Marie-Renée; Pommier, Jeanine

2012-01-01

For many years, researchers in a range of fields have combined quantitative and qualitative methods. However, the combined use of quantitative and qualitative methods has only recently been conceptualized and defined as mixed methods research. Some authors have described the emerging field as a third methodological tradition (in addition to the qualitative and quantitative traditions). Mixed methods research combines different perspectives and facilitates the study of complex interventions or programs, particularly in public health, an area where interdisciplinarity is critical. However, the existing literature is primarily in English. By contrast, the literature in French remains limited. The purpose of this paper is to present the emergence of mixed methods research for francophone public health specialists. A literature review was conducted to identify the main characteristics of mixed methods research. The results provide an overall picture of the mixed methods approach through its history, definitions, and applications, and highlight the tools developed to clarify the approach (typologies) and to implement it (integration of results and quality standards). The tools highlighted in the literature review are illustrated by a study conducted in France. Mixed methods research opens new possibilities for examining complex research questions and provides relevant and promising opportunities for addressing current public health issues in France.

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?

PubMed

Lussier, Alexandre A; Weinberg, Joanne; Kobor, Michael S

2017-03-01

Adverse in utero events can alter the development and function of numerous physiological systems, giving rise to lasting neurodevelopmental deficits. In particular, data have shown that prenatal alcohol exposure can reprogram neurobiological systems, altering developmental trajectories and resulting in increased vulnerability to adverse neurobiological, behavioral and health outcomes. Increasing evidence suggests that epigenetic mechanisms are potential mediators for the reprogramming of neurobiological systems, as they may provide a link between the genome, environmental conditions and neurodevelopmental outcomes. This review outlines the current state of epigenetic research in fetal alcohol spectrum disorder, highlighting the role of epigenetic mechanisms in the reprogramming of neurobiological systems by alcohol and as potential diagnostic tools for fetal alcohol spectrum disorder. We also present an assessment of the current limitations in studies of prenatal alcohol exposure, and highlight the future steps needed in the field.

USDA Biochar Research: Land Application Advances to Reap Its Multifunctional Abilities

NASA Astrophysics Data System (ADS)

Ippolito, J.; Spokas, K.; Novak, J.; Lentz, R. D.; Stromberger, M.; Ducey, T.; Johnson, M.

2014-12-01

Biochar is the solid byproduct from the pyrolysis of agricultural crop residues, manures, green wastes and wood-based materials. Pyrolyzing biomass causes inorganic and organic compounds to be concentrated within the carbonized remains of the original lignin and cellulose structure. It is through this complex mixture of organic aromatic structures and inorganic elements that potentially imparts biochars with special multi-functional capabilities. Our current research has focused on developing biochar to simultaneously sequester soil carbon and remediate degraded soils. This is accomplished by directly improving soil nutrient and moisture contents, sorbing pollutants, as well as altering microbial signaling. Maintaining these improvements needs to account for biochar physical degradation, which may be overcome by biochar-mineral associations. Additional research is focused on biochar use that minimizes soil microorganism population shifts in order to maintain current ecosystem services. Future USDA research involves more evaluations to understand the multifunctional role of biochar in the agricultural and environmental sectors (e.g., USEPA superfund locations). This presentation will provide highlights of current and future coordinated biochar research efforts from several key laboratory locations across the US.

A National MagLev Transportation System

NASA Technical Reports Server (NTRS)

Wright, Michael R.

2003-01-01

The case for a national high-speed magnetic-levitation (MagLev) transportation system is presented. Focus is on current issues facing the country, such as national security, the economy, transportation, technology, and the environment. NASA s research into MagLev technology for launch assist is also highlighted. Further, current socio-cultural norms regarding motor-vehicle-based transportation systems are questioned in light of the problems currently facing the U.S. The multidisciplinary benefits of a long-distance MagLev system support the idea that such a system would be an important element of a truly multimodal U.S. transportation infrastructure.

Presentation to Ohio State University Dept. of Electrical Engineering ElectroScience Laboratory

NASA Technical Reports Server (NTRS)

Fujikawa, Gene

2002-01-01

Presentation made during visit to The Ohio State University, ElectroScience Laboratory, on November 14, 2002. An overview of NASA and selected technology products from the Digital Communications Technology Branch (5650) for fiscal year 2003 are highlighted. The purpose of the meeting was to exchange technical information on current aeronautics and space communications research and technology being conducted at NASA Glenn Research Center and to promote faculty/student collaborations of mutual interest.

The Amphibian Research and Monitoring Initiative (ARMI): 5-year report

USGS Publications Warehouse

Muths, Erin; Gallant, Alisa L.; Campbell Grant, Evan H.; Battaglin, William A.; Green, David E.; Staiger, Jennifer S.; Walls, Susan C.; Gunzburger, Margaret S.; Kearney, Rick F.

2006-01-01

This report is a 5-year retrospective of the structure, methodology, progress, and contributions to the broader scientific community that have resulted from this national USGS program. We evaluate ARMI’s success to date, with regard to the challenges faced by the program and the strengths that have emerged. We chart objectives for the next 5 years that build on current accomplishments, highlight areas meriting further research, and direct efforts to overcome existing weaknesses.

Ultimate Atomic Bling: Nanotechnology of Diamonds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dahl, Jeremy

2010-05-25

Diamonds exist in all sizes, from the Hope Diamond to minuscule crystals only a few atoms across. The smallest of these diamonds are created naturally by the same processes that make petroleum. Recently, researchers discovered that these 'diamondoids' are formed in many different structural shapes, and that these shapes can be used like LEGO blocks for nanotechnology. This talk will discuss the discovery of these nano-size diamonds and highlight current SLAC/Stanford research into their applications in electronics and medicine.

Wireless connectivity for health and sports monitoring: a review.

PubMed

Armstrong, S

2007-05-01

This is a review of health and sports monitoring research that uses or could benefit from wireless connectivity. New, enabling wireless connectivity standards are evaluated for their suitability, and an assessment of current exploitation of these technologies is summarised. An example of the application is given, highlighting the capabilities of a network of wireless sensors. Issues of timing and power consumption in a battery-powered system are addressed to highlight the benefits networking can provide, and a suggestion of how monitoring different biometric signals might allow one to gain additional information about an athlete or patient is made.

Wireless connectivity for health and sports monitoring: a review

PubMed Central

Armstrong, S

2007-01-01

This is a review of health and sports monitoring research that uses or could benefit from wireless connectivity. New, enabling wireless connectivity standards are evaluated for their suitability, and an assessment of current exploitation of these technologies is summarised. An example of the application is given, highlighting the capabilities of a network of wireless sensors. Issues of timing and power consumption in a battery‐powered system are addressed to highlight the benefits networking can provide, and a suggestion of how monitoring different biometric signals might allow one to gain additional information about an athlete or patient is made. PMID:17224446

The use of electropalatography in the assessment and treatment of acquired motor speech disorders in adults: current knowledge and future directions.

PubMed

McAuliffe, Megan J; Ward, Elizabeth C

2006-01-01

Electropalatography (EPG) has been employed to measure speech articulation since the mid-1970s. This technique has predominately been used in experimental phonetic research and in the diagnosis and treatment of articulation disorders in children. However, there is a growing body of research employing EPG to diagnose and treat articulatory impairment associated with acquired motor speech disorder (MSD) in adults. The purpose of this paper was to (1) review the findings of studies pertaining to the assessment and treatment of MSDs in adults using EPG, (2) highlight current methodologies employed, and (3) discuss the potential limitations of EPG in the assessment and treatment of MSDs and examine directions for future applied research and treatment studies.

An Overview of Low-Emission Combustion Research

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

An overview of research efforts at NASA Glenn Research Center (GRC) in low-emission combustion technology that have made a significant impact on the Nitrogen Oxides (NOx) emission reduction in aircraft propulsion will be presented. The technology advancements and their impact on aircraft emissions will be discussed in the context of NASAs Aeronautics Research Mission Directorate (ARMD) high-level goals in fuel burn, noise and emission reductions. The highlights of the research presented will show how the past and current efforts have laid the foundation for the engines that are flying today as well as how the continued technology advancements will significantly influence the next generation of aviation propulsion system designs.

An Overview of Low-Emission Combustion Research at NASA Glenn

NASA Technical Reports Server (NTRS)

Reddy, Dhanireddy R.; Lee, Chi-Ming

2016-01-01

An overview of research efforts at NASA Glenn Research Center (GRC) in low-emission combustion technology that have made a significant impact on the nitrogen oxides (NOx) emission reduction in aircraft propulsion is presented. The technology advancements and their impact on aircraft emissions are discussed in the context of NASA's Aeronautics Research Mission Directorate (ARMD) high-level goals in fuel burn, noise and emission reductions. The highlights of the research presented here show how the past and current efforts laid the foundation for the engines that are flying today as well as how the continued technology advancements will significantly influence the next generation of aviation propulsion system designs.

Overview of Low Emission Combustion Research At NASA Glenn

NASA Technical Reports Server (NTRS)

Reddy, D. R.

2016-01-01

An overview of research efforts at NASA Glenn Research Center (GRC) in low-emission combustion technology that have made a significant impact on the nitrogen oxides (NOx) emission reduction in aircraft propulsion is presented. The technology advancements and their impact on aircraft emissions are discussed in the context of NASA's Aeronautics Research Mission Directorate (ARMD) high-level goals in fuel burn, noise and emission reductions. The highlights of the research presented here show how the past and current efforts laid the foundation for the engines that are flying today as well as how the continued technology advancements will significantly influence the next generation of aviation propulsion system designs.

School nurses can address existing gaps in school-age sleep research.

PubMed

Willgerodt, Mayumi A; Kieckhefer, Gail M

2013-06-01

Sleep has been linked to a host of physical, behavioral, and emotional outcomes, and research has documented that youth across the globe are experiencing inadequate sleep. Despite this knowledge, however, very little research has been conducted on school-age children; much of the extant research has focused on infants, toddlers, preschoolers, adolescents, and adults. School-age children exhibit increasing independence around health-related behaviors, which provide health professionals the opportunity to educate and promote healthy sleep behaviors. This commentary extends previous research reviews by identifying the current gaps in sleep research, highlighting future directions needed in sleep research, and explaining why school nurses are best suited to address this growing public health issue.

Identifying the immunomodulatory components of helminths.

PubMed

Shepherd, C; Navarro, S; Wangchuk, P; Wilson, D; Daly, N L; Loukas, A

2015-06-01

Immunomodulatory components of helminths offer great promise as an entirely new class of biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes in helminth-driven immunomodulation in the context of therapeutic drug discovery. We broadly define the approaches that are currently applied by researchers to identify these helminth molecules, highlighting key areas of potential exploitation that have been mostly neglected thus far, notably small molecules. Finally, we propose that the investigation of immunomodulatory compounds will enable the translation of current and future research efforts into potential treatments for autoimmune and allergic diseases, while at the same time yielding new insights into the molecular interface of host-parasite biology. © 2015 John Wiley & Sons Ltd.

Highlights from Drugs and the Class of '78: Behaviors, Attitudes, and Recent National Trends.

ERIC Educational Resources Information Center

Johnston, Lloyd D.; And Others

The current prevalence of drug use among American high school seniors (classes of 1975 through 1978) was investigated through a program entitled "Monitoring the Future: A Continuing Study of the Lifestyles and Values of Youth," conducted by the University of Michigan's Institute for Social Research and funded by the National Institute on Drug…

Keeping Current: Doing It with Style for Different Folks: Learning Styles for School Library Media Specialists.

ERIC Educational Resources Information Center

Barron, Daniel D.

1997-01-01

Understanding learning styles can help teachers get beyond lecture, text, and test. This article reviews some of the research and literature on learning styles, highlighting the Myers-Briggs Type Indicator, the Keirsey Temperament Sorter, the 4-MAT System, and Attention Deficit Disorder (ADD). Includes related Web sites and print resources. (PEN)

Engagement as a Core University Leadership Position and Advancement Strategy: Perspectives from an Engaged Institution

ERIC Educational Resources Information Center

Langseth, Mark N.; McVeety, Cassie S.

2007-01-01

Over the past decade, Portland State University (PSU) has received consistent national accolades for its innovative, engaged approaches to student learning. More recently, PSU has expanded its emphasis on engaged research and has more intentionally highlighted its institutional partnerships and impact on the region. A current (2006-07)…

The Role of the Occupational Therapist in the Treatment of Children with Eating Disorders

ERIC Educational Resources Information Center

Bradford, Robert; Holliday, Megan; Schultz, Amy; Moser, Christy

2015-01-01

The prevalence of childhood eating disorders is increasing in pediatric practice across the country. It is therefore important for occupational therapists to be familiar with current research, resources, and intervention strategies related to a variety of eating diagnoses. In this column we highlight basic definitions of a variety of eating…

The Khat and Meow Meow Tale: Teaching the Relevance of Chemistry through Novel Recreational Drugs

ERIC Educational Resources Information Center

Fergus, Suzanne; Kellett, Kathryn; Gerhard, Ute

2015-01-01

Using current research and real-life scenarios to motivate students to understand chemistry principles is a key strategy in learning and teaching. An illustration of psychoactive drugs referred to as "legal highs" used in the U.K. and Europe is presented to highlight key chemistry principles and relate the importance of chemistry…

Effective E-Learning? Multi-Tasking, Distractions and Boundary Management by Graduate Students in an Online Environment

ERIC Educational Resources Information Center

Winter, Jennie; Cotton, Debby; Gavin, Joan; Yorke, Jon D.

2010-01-01

This paper reports the findings of a small-scale study that documented the use of information technology for learning by a small group of postgraduate students. Our findings support current knowledge about characteristics displayed by effective e-learners, but also highlight a less researched but potentially important issue in developing…

A Framework for Quality K-12 Engineering Education: Research and Development

ERIC Educational Resources Information Center

Moore, Tamara J.; Glancy, Aran W.; Tank, Kristina M.; Kersten, Jennifer A.; Smith, Karl A.; Stohlmann, Micah S.

2014-01-01

Recent U.S. national documents have laid the foundation for highlighting the connection between science, technology, engineering and mathematics at the K-12 level. However, there is not a clear definition or a well-established tradition of what constitutes a quality engineering education at the K-12 level. The purpose of the current work has been…

Engaging communities and climate change futures with Multi-Scale, Iterative Scenario Building (MISB) in the western United States

Treesearch

Daniel Murphy; Carina Wyborn; Laurie Yung; Daniel R. Williams; Cory Cleveland; Lisa Eby; Solomon Dobrowski; Erin Towler

2016-01-01

Current projections of future climate change foretell potentially transformative ecological changes that threaten communities globally. Using two case studies from the United States Intermountain West, this article highlights the ways in which a better articulation between theory and methods in research design can generate proactive applied tools that enable...

Identifying the Real Technology Skills Gap: A Qualitative Look across Disciplines

ERIC Educational Resources Information Center

Schirf, Evan; Serapiglia, Anthony

2017-01-01

Every year several survey inventories are performed throughout the IT industry by trade magazines and research groups that attempt to gauge the current state of the industry as it relates to trends. Many of these highlight a technology skills gap between job expectations and potential employees. While many job openings exist and educational…

Aerospace applications of PMR polyimide composites

NASA Technical Reports Server (NTRS)

Serafini, T. T.

1985-01-01

The current status of the novel class of processable, addition-type polyimides known as PMR (for in situ polymerization of monomer reactants) polyimides, developed by NASA at the Lewis Research Center, is reviewed. Highlights of PMR technology studies conducted at NASA Lewis are presented. Several examples of industrial applications of PMR-15 polyimide composites to aerospace structural components are examined.

Treatment Services for Drug Dependent Women. Volume 1. Treatment Research Monograph Series.

ERIC Educational Resources Information Center

Beschner, George M., Ed.; And Others

This book is the first of two volumes designed to highlight and integrate current knowledge about drug dependent women, with a focus on needed services and appropriate delivery systems, as well as to provide useful information for counselors and treatment program developers. The special problems, needs, and characteristics of women drug abusers…

Aeropropulsion 1987. Session 4: Instrumentation and Controls Research

NASA Technical Reports Server (NTRS)

1987-01-01

The Lewis Research Center has had a long history of research directed toward advancing the national capability in the areas of propulsion research instrumentation and propulsion controls. Some of the major advances from this research that are currently in use are highlighted as well as some of the ongoing and planned research that will strongly impact the future capabilities. The presentations will cover the efforts on research instrumentation and controls as well as the research on high temperature electronics. This introductory section will focus on the major drivers or needs of the aeropropulsion industry that have shaped the instrumentation and controls research programs. Also covered will be the technological opportunities that have greatly impacted the program and that permitted break-throughs in several areas.

Intervention among Suicidal Men: Future Directions for Telephone Crisis Support Research.

PubMed

Hunt, Tara; Wilson, Coralie J; Woodward, Alan; Caputi, Peter; Wilson, Ian

2018-01-01

Telephone crisis support is a confidential, accessible, and immediate service that is uniquely set up to reduce male suicide deaths through crisis intervention. However, research focusing on telephone crisis support with suicidal men is currently limited. To highlight the need to address service delivery for men experiencing suicidal crisis, this perspective article identifies key challenges facing current telephone crisis support research and proposes that understanding of the role of telephone crisis helplines in supporting suicidal men may be strengthened by careful examination of the context of telephone crisis support, together with the impact this has on help-provision for male suicidal callers. In particular, the impact of the time- and information-poor context of telephone crisis support on crisis-line staff's identification of, and response to, male callers with thoughts of suicide is examined. Future directions for research in the provision of telephone crisis support for suicidal men are discussed.

Intervention among Suicidal Men: Future Directions for Telephone Crisis Support Research

PubMed Central

Hunt, Tara; Wilson, Coralie J.; Woodward, Alan; Caputi, Peter; Wilson, Ian

2018-01-01

Telephone crisis support is a confidential, accessible, and immediate service that is uniquely set up to reduce male suicide deaths through crisis intervention. However, research focusing on telephone crisis support with suicidal men is currently limited. To highlight the need to address service delivery for men experiencing suicidal crisis, this perspective article identifies key challenges facing current telephone crisis support research and proposes that understanding of the role of telephone crisis helplines in supporting suicidal men may be strengthened by careful examination of the context of telephone crisis support, together with the impact this has on help-provision for male suicidal callers. In particular, the impact of the time- and information-poor context of telephone crisis support on crisis-line staff’s identification of, and response to, male callers with thoughts of suicide is examined. Future directions for research in the provision of telephone crisis support for suicidal men are discussed. PMID:29404319

Journal rankings and directions for future research in health care management: A global perspective.

PubMed

Meese, Katherine A; O'Connor, Stephen J; Borkowski, Nancy; Hernandez, S Robert

2017-05-01

Despite the increasingly global nature of health care, much of the research about journal rankings and directions for future research in health care management is from a United States based viewpoint. There is a lack of information about influential journals and trends for health care management research from a global perspective. This exploratory study gathered the opinions of health care management researchers from 17 countries regarding which journals are considered most influential, popular research topics and areas needing more attention from the research community. An online survey was sent to individuals in high-income Organisation for Economic Co-operation and Development countries who were identified through author relationships, academic institution websites, editorial boards of international journals, and academic and practitioner associations in the countries of interest. Results indicate that journal rankings vary substantially from prior published studies evaluating health care management journals and international ranking lists, and the list of influential journals includes a much more diverse array of publications. Respondents also indicated a diverse number of topics for current and future research, highlighting the global complexity of the field. The implications of this study are valuable to scholars evaluating outlets for disseminating research, and highlighting areas for collaborative research in health care management globally.

Recent advances in transfusions in neonates/infants

PubMed Central

Goel, Ruchika; Josephson, Cassandra D.

2018-01-01

Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age. It is entering an exciting era with recognition as an independent discipline, a new and evolving high-quality evidence base for transfusion practices, novel technologies and therapeutics, and national/international collaborative research, educational, and clinical efforts. Triggers and thresholds for red cell transfusion are accumulating evidence with current phase III clinical trials. Ongoing trials and studies of platelet and plasma transfusions in neonates are anticipated to provide high-quality evidence in years to come. This article aims to summarize the most current evidence-based practices regarding blood component therapy in neonates. Data on the use of specific components (RBCs, plasma, and platelets) are provided. We attempt to define thresholds for anemia, thrombocytopenia, and abnormal coagulation profile in neonates to highlight the difficulties in having a specific cutoff value in neonates and preterm infants. Indications for transfusion of specific products, transfusion thresholds, and current practices and guidelines are provided, and possible adverse outcomes and complications are discussed. Finally, the critical research knowledge gaps in these practices as well as ongoing and future research areas are discussed. In an era of personalized medicine, neonatal transfusion decisions guided by a strong evidence base must be the overarching goal, and this underlies all of the strategic initiatives in pediatric and neonatal transfusion research highlighted in this article. PMID:29904575

Across the Board: Nam-Gyu Park.

PubMed

Park, Nam-Gyu

2016-09-22

In this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. Nam-Gyu Park, who highlights the recent work on mixed-cation mixed-anion perovskite materials toward high efficiency perovskite solar cells. He summarizes the work that has brought us to the current stage of research and suggests possible future paths for further advancement. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

NASA earth science and applications division: The program and plans for FY 1988-1989-1990

NASA Technical Reports Server (NTRS)

1988-01-01

Described here are the Division's research goals, priorities and emphases for the next several years and an outline of longer term plans. Included are highlights of recent accomplishments, current activities in FY 1988, research emphases in FY 1989, and longer term future plans. Data and information systems, the Geodynamics Program, the Land Processes Program, the Oceanic Processes Program, the Atmospheric Dynamics and Radiation Program, the Atmospheric Chemistry Program, and space flight programs are among the topic covered.

Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science.

PubMed

Huang, Kun; Liu, Yunlong; Huang, Yufei; Li, Lang; Cooper, Lee; Ruan, Jianhua; Zhao, Zhongming

2016-08-22

We summarize the 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) and the editorial report of the supplement to BMC Genomics. The supplement includes 20 research articles selected from the manuscripts submitted to ICIBM 2015. The conference was held on November 13-15, 2015 at Indianapolis, Indiana, USA. It included eight scientific sessions, three tutorials, four keynote presentations, three highlight talks, and a poster session that covered current research in bioinformatics, systems biology, computational biology, biotechnologies, and computational medicine.

Bioenvironmental aspects of europium and rhodium: a selected bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fore, C.S.; Carrier, R.F.; Talmage, S.S.

This bibliography of 428 abstracted references represents a summary of the domestic and foreign literature relevant to the biological and environmental aspects of europium and rhodium. The collected data are organized by current NAEG interests - research highlighting inventory and distribution of the radionulcides, ecological studies covering terrestrial and aquatic systems, and biological studies in both man and animals. Studies that focus directly on research conducted at specific sites (e.g., the Nevada Test Site) are emphasized throughout the bibliography. (ACR)

Transmission Pathways and Mediators as the Basis for Clinical Pharmacology of Pain

PubMed Central

Kirkpatrick, Daniel R.; McEntire, Dan M.; Smith, Tyler A.; Dueck, Nicholas P.; Kerfeld, Mitchell J.; Hambsch, Zakary J.; Nelson, Taylor J.; Reisbig, Mark D.; Agrawal, Devendra K.

2016-01-01

Introduction Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas Covered The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert Commentary This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury. PMID:27322358

Developing the Mental Health Workforce: Review and Application of Training Approaches from Multiple Disciplines

PubMed Central

Lyon, Aaron R.; Stirman, Shannon Wiltsey; Kerns, Suzanne E. U.; Bruns, Eric J.

2011-01-01

Strategies specifically designed to facilitate the training of mental health practitioners in evidence-based practices (EBPs) have lagged behind the development of the interventions themselves. The current paper draws from an interdisciplinary literature (including medical training, adult education, and teacher training) to identify useful training and support approaches as well as important conceptual frameworks that may be applied to training in mental health. Theory and research findings are reviewed, which highlight the importance of continued consultation/ support following training workshops, congruence between the training content and practitioner experience, and focus on motivational issues. In addition, six individual approaches are presented with careful attention to their empirical foundations and potential applications. Common techniques are highlighted and applications and future directions for mental health workforce training and research are discussed. PMID:21190075

Diverging Influences of Money Priming on Choice.

PubMed

Kim, Hee Jin

2017-01-01

Prior research on money priming has suggested two seemingly contradicting findings. On the one hand, money has been shown to highlight the importance of cost saving, leading to the choice of a low-quality/low-price option. On the other hand, individuals primed with money as a symbol of social status, and capabilities may focus on social value of money, e.g., higher spending symbolizes higher status and prefer an option with high quality/high price. Current research proposes and demonstrates that whether money priming will lead different choices depends on the nature of the consumption context. Specifically, when the product is to be consumed privately, money priming will highlight the importance of cost, thus increasing the preference for lower price at a lower quality. However, when the product is to be consumed publicly, reversed pattern of consumer preference will be found.

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts.

PubMed

Nwosu, Zeribe C; Alborzinia, Hamed; Wölfl, Stefan; Dooley, Steven; Liu, Yan

2016-01-01

Liver myofibroblasts (MFB) are crucial mediators of extracellular matrix (ECM) deposition in liver fibrosis. They arise mainly from hepatic stellate cells (HSCs) upon a process termed "activation." To a lesser extent, and depending on the cause of liver damage, portal fibroblasts, mesothelial cells, and fibrocytes may also contribute to the MFB population. Targeting MFB to reduce liver fibrosis is currently an area of intense research. Unfortunately, a clog in the wheel of antifibrotic therapies is the fact that although MFB are known to mediate scar formation, and participate in liver inflammatory response, many of their molecular portraits are currently unknown. In this review, we discuss recent understanding of MFB in health and diseases, focusing specifically on three evolving research fields: metabolism, autophagy, and epigenetics. We have emphasized on therapeutic prospects where applicable and mentioned techniques for use in MFB studies. Subsequently, we highlighted uncharted territories in MFB research to help direct future efforts aimed at bridging gaps in current knowledge.

Imaging flow cytometry for phytoplankton analysis.

PubMed

Dashkova, Veronika; Malashenkov, Dmitry; Poulton, Nicole; Vorobjev, Ivan; Barteneva, Natasha S

2017-01-01

This review highlights the concepts and instrumentation of imaging flow cytometry technology and in particular its use for phytoplankton analysis. Imaging flow cytometry, a hybrid technology combining speed and statistical capabilities of flow cytometry with imaging features of microscopy, is rapidly advancing as a cell imaging platform that overcomes many of the limitations of current techniques and contributed significantly to the advancement of phytoplankton analysis in recent years. This review presents the various instrumentation relevant to the field and currently used for assessment of complex phytoplankton communities' composition and abundance, size structure determination, biovolume estimation, detection of harmful algal bloom species, evaluation of viability and metabolic activity and other applications. Also we present our data on viability and metabolic assessment of Aphanizomenon sp. cyanobacteria using Imagestream X Mark II imaging cytometer. Herein, we highlight the immense potential of imaging flow cytometry for microalgal research, but also discuss limitations and future developments. Copyright © 2016 Elsevier Inc. All rights reserved.

European League against rheumatism - selected presentation and poster a highlights June 11th to 13th 2013.

PubMed

Braddock, Martin

2014-02-01

The heterogeneous pathology of many autoimmune diseases warrants the continual discovery and development of new drugs. Drawing on selected oral presentations and selected poster displays, this article highlights some new developments in the pharmacological validation of molecular targets implicated in inflammatory autoimmune disease and may be of direct importance to scientists working in this field. This report describes the current state of the pharmacology of selected drugs and targets which may have utility in modulating immune function and autoimmune inflammatory disease. Many new molecules are progressing through clinical development for the treatment of rheumatological diseases. The value of the basic nonclinical and clinical research presented is to further pharmacological knowledge of the molecule, better understand the benefit-risk associated with clinical development and to assist in supporting the potential position of a new drug in the current treatment paradigm.

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?

PubMed Central

Lussier, Alexandre A; Weinberg, Joanne; Kobor, Michael S

2017-01-01

Adverse in utero events can alter the development and function of numerous physiological systems, giving rise to lasting neurodevelopmental deficits. In particular, data have shown that prenatal alcohol exposure can reprogram neurobiological systems, altering developmental trajectories and resulting in increased vulnerability to adverse neurobiological, behavioral and health outcomes. Increasing evidence suggests that epigenetic mechanisms are potential mediators for the reprogramming of neurobiological systems, as they may provide a link between the genome, environmental conditions and neurodevelopmental outcomes. This review outlines the current state of epigenetic research in fetal alcohol spectrum disorder, highlighting the role of epigenetic mechanisms in the reprogramming of neurobiological systems by alcohol and as potential diagnostic tools for fetal alcohol spectrum disorder. We also present an assessment of the current limitations in studies of prenatal alcohol exposure, and highlight the future steps needed in the field. PMID:28234026

Butterfly genomics eclosing.

PubMed

Beldade, P; McMillan, W O; Papanicolaou, A

2008-02-01

Technological and conceptual advances of the last decade have led to an explosion of genomic data and the emergence of new research avenues. Evolutionary and ecological functional genomics, with its focus on the genes that affect ecological success and adaptation in natural populations, benefits immensely from a phylogenetically widespread sampling of biological patterns and processes. Among those organisms outside established model systems, butterflies offer exceptional opportunities for multidisciplinary research on the processes generating and maintaining variation in ecologically relevant traits. Here we highlight research on wing color pattern variation in two groups of Nymphalid butterflies, the African species Bicyclus anynana (subfamily Satyrinae) and species of the South American genus Heliconius (subfamily Heliconiinae), which are emerging as important systems for studying the nature and origins of functional diversity. Growing genomic resources including genomic and cDNA libraries, dense genetic maps, high-density gene arrays, and genetic transformation techniques are extending current gene mapping and expression profiling analysis and enabling the next generation of research questions linking genes, development, form, and fitness. Efforts to develop such resources in Bicyclus and Heliconius underscore the general challenges facing the larger research community and highlight the need for a community-wide effort to extend ongoing functional genomic research on butterflies.

Latino recruitment to cancer prevention/screening trials in the Southwest: setting a research agenda.

PubMed

Larkey, Linda K; Ogden, Sheryl L; Tenorio, Sally; Ewell, Teresa

2008-02-01

Examples of cancer prevention and screening trials in the Southwest are reviewed as a platform for highlighting gaps in research on Latino recruitment. Three trials are described, using "message/source/channel" categories as a framework. Each trial engaged community members to facilitate recruitment and developed tailored strategies to meet challenges emerging after recruitment began. Although we affirm that culturally relevant messages, community member referral networks, and adjustment to community realities seem important to Latino recruitment, current anecdotal and research findings do not allow evidence-based recommendations to be made. We suggest a research agenda to further illuminate critical factors for successful Latino recruitment.

Review of research and developments in self healing composite materials

NASA Astrophysics Data System (ADS)

Reddy Madara, Sahith; Sarath Raj, N. S.; Pon Selvan, Chithirai, Dr.

2018-04-01

Self-healing materials are artificial or synthetically created substances that have the built-in ability to automatically repair damage to themselves without any external diagnosis of the problem or human intervention. This article presents the current research and developments in self-healing composite materials. A detailed study is conducted on various types of self-healing composites with their self-healing mechanisms. The applications of self-healing materials in various fields including space sector is also discussed. Economics and Future outlooks for self-healing smart materials is highlighted at the end of the article. This research article will be useful to manufacturers, policy makers and researchers widely.

Ionic Liquid-Based Optical and Electrochemical Carbon Dioxide Sensors.

PubMed

Behera, Kamalakanta; Pandey, Shubha; Kadyan, Anu; Pandey, Siddharth

2015-12-04

Due to their unusual physicochemical properties (e.g., high thermal stability, low volatility, high intrinsic conductivity, wide electrochemical windows and good solvating ability), ionic liquids have shown immense application potential in many research areas. Applications of ionic liquid in developing various sensors, especially for the sensing of biomolecules, such as nucleic acids, proteins and enzymes, gas sensing and sensing of various important ions, among other chemosensing platforms, are currently being explored by researchers worldwide. The use of ionic liquids for the detection of carbon dioxide (CO₂) gas is currently a major topic of research due to the associated importance of this gas with daily human life. This review focuses on the application of ionic liquids in optical and electrochemical CO₂ sensors. The design, mechanism, sensitivity and detection limit of each type of sensor are highlighted in this review.

Pharmacological treatment of anxiety disorders: Current treatments and future directions✩

PubMed Central

Farach, Frank J.; Pruitt, Larry D.; Jun, Janie J.; Jerud, Alissa B.; Zoellner, Lori A.; Roy-Byrne, Peter P.

2012-01-01

Modern pharmacological treatments for anxiety disorders are safer and more tolerable than they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in most cases despite a greater understanding of the pathophysiology of anxiety. Moreover, innovative treatments have not reached the market despite billions of research dollars invested in drug development. In reviewing the literature on current treatments, we argue that evidence-based practice would benefit from better research on the causes of incomplete treatment response as well as the comparative efficacy of drug combinations and sequencing. We also survey two broad approaches to the development of innovative anxiety treatments: the continued development of drugs based on specific neuroreceptors and the pharmacological manipulation of fear-related memory. We highlight directions for future research, as neither of these approaches is ready for routine clinical use. PMID:23023162

Ionic Liquid-Based Optical and Electrochemical Carbon Dioxide Sensors

PubMed Central

Behera, Kamalakanta; Pandey, Shubha; Kadyan, Anu; Pandey, Siddharth

2015-01-01

Due to their unusual physicochemical properties (e.g., high thermal stability, low volatility, high intrinsic conductivity, wide electrochemical windows and good solvating ability), ionic liquids have shown immense application potential in many research areas. Applications of ionic liquid in developing various sensors, especially for the sensing of biomolecules, such as nucleic acids, proteins and enzymes, gas sensing and sensing of various important ions, among other chemosensing platforms, are currently being explored by researchers worldwide. The use of ionic liquids for the detection of carbon dioxide (CO2) gas is currently a major topic of research due to the associated importance of this gas with daily human life. This review focuses on the application of ionic liquids in optical and electrochemical CO2 sensors. The design, mechanism, sensitivity and detection limit of each type of sensor are highlighted in this review. PMID:26690155

Intermediate-energy nuclear chemistry workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, G.W.; Giesler, G.C.; Liu, L.C.

1981-05-01

This report contains the proceedings of the LAMPF Intermediate-Energy Nuclear Chemistry Workshop held in Los Alamos, New Mexico, June 23-27, 1980. The first two days of the Workshop were devoted to invited review talks highlighting current experimental and theoretical research activities in intermediate-energy nuclear chemistry and physics. Working panels representing major topic areas carried out indepth appraisals of present research and formulated recommendations for future research directions. The major topic areas were Pion-Nucleus Reactions, Nucleon-Nucleus Reactions and Nuclei Far from Stability, Mesonic Atoms, Exotic Interactions, New Theoretical Approaches, and New Experimental Techniques and New Nuclear Chemistry Facilities.

Finding value from IT investments: exploring the elusive ROI in healthcare.

PubMed

Vogel, Lynn H

2003-01-01

This article explores the historical IT value research, discusses its applicability to IT investments in healthcare, and highlights how it is challenged by several factors unique to the healthcare industry. The integration of historical IT value research with healthcare industry attributes provides an important context for understanding why the IT value proposition in healthcare has been so elusive. The article also poses a set of guidelines, which, based on the IT value research outside of healthcare, may assist in alleviating some of the current frustration with determining the value of healthcare IT investments.

Toward a psychopathology of self-control theory: the importance of narcissistic traits.

PubMed

Vaughn, Michael G; DeLisi, Matt; Beaver, Kevin M; Wright, John Paul; Howard, Matthew O

2007-01-01

Research on self-control and related constructs is central to individual-level explanations of antisocial behavior. However, less research attention has been paid to the psychopathological underpinnings of self-control. The current study explores relationships between self-control and psychiatric symptoms, head injury, trauma history, substance use, guiltlessness and narcissistic traits in a statewide population of juvenile offenders. Results support the importance of these variables, in particular narcissistic traits, in better explicating theories of self-control. Implications for research on the psychopathological underpinnings of self-control are highlighted. Copyright (c) 2007 John Wiley & Sons, Ltd.

X-Ray astronomy the 1980's. [conferences

NASA Technical Reports Server (NTRS)

Holt, S. S. (Editor)

1981-01-01

The status of the current understanding of important problems to which X-ray astronomical techniques can be applied is summarized and the prospects for such research in the future is discussed. Relatively near-term X-ray astronomical research objectives are presented. The importance of a continuing program of balloon-borne research as a cost effective means by which studies at energies in excess of 20 keV may be performed is emphasized. The scientific opportunities presented by the Space Transpotation System to develop low cost experiments which are beyond the scope of balloon-borne capabilities are also highlighted.

Working towards a consensus for antibody validation.

PubMed

Reiss, Peter D; Min, Danxi; Leung, Mei Y

2014-01-01

Commercial research antibodies are the most commonly used product in the life science tools market, and their applications represent a significant investment of time and resources for researchers. Frequently however, the quality of antibodies does not meet the expectations of consumers, causing loss of valuable time and money. This can delay research efforts and scientific discovery, or even lead to false, irreproducible results to be published in the scientific literature. This raises the question of whether there should be universal standards for validating antibodies.   During the 1 (st) International Antibody Validation Forum, hosted by St John's Laboratory Ltd on October 15 (th) 2014 at Queen Mary University of London, scientists from academia and industry presented data highlighting quality issues arising from lack of antibody validation. While the forum identified significant current problems in the antibody market, it also discussed future opportunities for improved quality and transparency by encouraging data disclosure and data sharing. This article highlights the key issues and conclusions reached at the forum.

The Big Breakfast Study: Chrono-nutrition influence on energy expenditure and bodyweight.

PubMed

Ruddick-Collins, L C; Johnston, J D; Morgan, P J; Johnstone, A M

2018-06-01

A growing body of evidence highlights the importance of the biological clock as a modulator of energy balance and metabolism. Recent studies in humans have shown that ingested calories are apparently utilised more efficiently in the morning than in the evening and this is manifest through improved weight loss, even under iso-energetic calorie intake. The mechanisms behind this enhanced morning energy metabolism are not yet clear, although it may result from behavioural adaptations or circadian driven variations in physiology and energy metabolism. A major objective of the newly funded Big Breakfast Study therefore is to investigate the mechanistic basis of this amplified morning thermogenesis leading to enhanced weight loss, by exploring behavioural and physiological adaptations in energy expenditure alongside the underlying circadian biology. This report briefly discusses the current research linking meal timing, circadian rhythms and metabolism; highlights the research gaps; and provides an overview of the studies being undertaken as part of the Medical Research Council-funded Big Breakfast Study .

Mapping human dimensions of climate change research in the Canadian Arctic.

PubMed

Ford, James D; Bolton, Kenyon; Shirley, Jamal; Pearce, Tristan; Tremblay, Martin; Westlake, Michael

2012-12-01

This study maps current understanding and research trends on the human dimensions of climate change (HDCC) in the eastern and central Canadian Arctic. Developing a systematic literature review methodology, 117 peer reviewed articles are identified and examined using quantitative and qualitative methods. The research highlights the rapid expansion of HDCC studies over the last decade. Early scholarship was dominated by work documenting Inuit observations of climate change, with research employing vulnerability concepts and terminology now common. Adaptation studies which seek to identify and evaluate opportunities to reduce vulnerability to climate change and take advantage of new opportunities remain in their infancy. Over the last 5 years there has been an increase social science-led research, with many studies employing key principles of community-based research. We currently have baseline understanding of climate change impacts, adaptation, and vulnerability in the region, but key gaps are evident. Future research needs to target significant geographic disparities in understanding, consider risks and opportunities posed by climate change outside of the subsistence hunting sector, complement case study research with regional analyses, and focus on identifying and characterizing sustainable and feasible adaptation interventions.

Drug targeting of oncogenic pathways in melanoma.

PubMed

Fecher, Leslie A; Amaravadi, Ravi K; Schuchter, Lynn M; Flaherty, Keith T

2009-06-01

Melanoma continues to be one of the most aggressive and morbid malignancies once metastatic. Overall survival for advanced unresectable melanoma has not changed over the past several decades. However, the presence of some long-term survivors of metastatic melanoma highlights the heterogeneity of this disease and the potential for improved outcomes. Current research is uncovering the molecular and genetic scaffolding of normal and aberrant cell function. The known oncogenic pathways in melanoma and the attempts to develop therapy for them are discussed. The targeting of certain cellular processes, downstream of the common genetic alterations, for which the issues of target and drug validation are somewhat distinct, are also highlighted.

The diversity, ecology and evolution of extrafloral nectaries: current perspectives and future challenges

PubMed Central

Marazzi, Brigitte; Bronstein, Judith L.; Koptur, Suzanne

2013-01-01

Background Plants in over one hundred families in habitats worldwide bear extrafloral nectaries (EFNs). EFNs display a remarkable diversity of evolutionary origins, as well as diverse morphology and location on the plant. They secrete extrafloral nectar, a carbohydrate-rich food that attracts ants and other arthropods, many of which protect the plant in return. By fostering ecologically important protective mutualisms, EFNs play a significant role in structuring both plant and animal communities. And yet researchers are only now beginning to appreciate their importance and the range of ecological, evolutionary and morphological diversity that EFNs exhibit. Scope This Highlight features a series of papers that illustrate some of the newest directions in the study of EFNs. Here, we introduce this set of papers by providing an overview of current understanding and new insights on EFN diversity, ecology and evolution. We highlight major gaps in our current knowledge, and outline future research directions. Conclusions Our understanding of the roles EFNs play in plant biology is being revolutionized with the use of new tools from developmental biology and genomics, new modes of analysis allowing hypothesis-testing in large-scale phylogenetic frameworks, and new levels of inquiry extending to community-scale interaction networks. But many central questions remain unanswered; indeed, many have not yet been asked. Thus, the EFN puzzle remains an intriguing challenge for the future. PMID:23704115

NASA GSFC Strategic Nanotechnology Interests: Symposium on High-Rate Nanoscale Printing for Devices and Structures

NASA Technical Reports Server (NTRS)

Ericsson, Aprille J.

2014-01-01

The seminars invitees include representatives from industry, nonprofit research facility and universities. The presentation provides an overview of the NASAGSFC locations, technical capabilities and applied nanotechnology interests. Initially presented are advances by the broader technological communities on current miniaturized multiscale advanced manufacturing and 3D printing products on the micro and macro scale. Briefly assessed is the potential of moving toward the nanoscale for possible space flight applications and challenges. Lastly, highlighted are GSFCs current successes in nano-technology developments and targeted future applications.

Torus Breakdown and Homoclinic Chaos in a Glow Discharge Tube

NASA Astrophysics Data System (ADS)

Ginoux, Jean-Marc; Meucci, Riccardo; Euzzor, Stefano

2017-12-01

Starting from historical researches, we used, like Van der Pol and Le Corbeiller, a cubic function for modeling the current-voltage characteristic of a direct current low-pressure plasma discharge tube, i.e. a neon tube. This led us to propose a new four-dimensional autonomous dynamical system allowing to describe the experimentally observed phenomenon. Then, mathematical analysis and detailed numerical investigations of such a fourth-order torus circuit enabled to highlight bifurcation routes from torus breakdown to homoclinic chaos following the Newhouse-Ruelle-Takens scenario.

Transdisciplinary translational behavioral (TDTB) research: opportunities, barriers, and innovations.

PubMed

Czajkowski, Susan M; Lynch, Minda R; Hall, Kara L; Stipelman, Brooke A; Haverkos, Lynne; Perl, Harold; Scott, Marcia S; Shirley, Mariela C

2016-03-01

The translation of basic behavioral science discoveries into practical strategies represents a promising approach to developing more effective preventive interventions to improve health. Since translational research inevitably involves making use of diverse perspectives from multiple disciplines, it is best conducted as a transdisciplinary enterprise. In this paper, we discuss current strategies used by NIH to support transdisciplinary translational behavioral (TDTB) research, summarize successful efforts, and highlight challenges encountered in conducting such work (ranging from conceptual to organizational to methodological). Using examples from NIH-funded projects we illustrate the potential benefits of, and barriers to, pursuing this type of research and discuss next steps and potential future directions for NIH-supported TDTB research.

National Freshman Attitudes Report, 2012. An Exploration of Attitudes That Influence Student Success. Seventh Annual National Research Study

ERIC Educational Resources Information Center

Noel-Levitz, Inc, 2012

2012-01-01

This annual report describes self-reported attitudes and motivations of today's first-year college students throughout the nation, based on survey responses from a sizable sample of freshmen attending college during the current academic year, 2011-2012. Among the highlights: (1) Compared to their female counterparts, many more incoming first-year…

Discussing Terrorism: A Pupil-Inspired Guide to UK Counter-Terrorism Policy Implementation in Religious Education Classrooms in England

ERIC Educational Resources Information Center

Quartermaine, Angela

2016-01-01

My research into pupils' perceptions of terrorism and current UK counter-terrorism policy highlights the need for more detailed and accurate discussions about the implementation of the educational aims, in particular those laid out by the Prevent Strategy. Religious education (RE) in England is affected by these aims, specifically the challenging…

107 Range Commanders Council Meteorology Group Meeting (RCC-MG): NASA Marshall Space Flight Center Range Report

NASA Technical Reports Server (NTRS)

Roberts, Barry C.

2016-01-01

The following is a summary of the major meteorological/atmospheric projects and research that have been or currently are being accomplished at Marshall Space Flight Center (MSFC). Listed below are highlights of work done during the past 6 months in the Engineering Directorate (ED) and in the Science and Mission Systems Office (ZP).

A need for standardization in visual acuity measurement.

PubMed

Patel, Hina; Congdon, Nathan; Strauss, Glenn; Lansingh, Charles

2017-01-01

Standardization of terminologies and methods is increasingly important in all fields including ophthalmology, especially currently when research and new technology are rapidly driving improvements in medicine. This review highlights the range of notations used by vision care professionals around the world for vision measurement, and the challenges resulting from this practice. The global community is urged to move toward a uniform standard.

Self and Identity in Early Adolescence: Some Reflections and an Introduction to the Special Issue

ERIC Educational Resources Information Center

Schwartz, Seth J.

2008-01-01

This article reviews contemporary issues in the study of self and identity and introduces the special issue. Particularly highlighted are the need to integrate the various currents in self and identity, the need to study the role of context in the development of self and identity, research on self and identity in ethnic minority and international…

The potential to build current natural gas infrastructure to accommodate the future conversion to near-zero transportation technology : a research report from the National Center for Sustainable Transportation.

DOT National Transportation Integrated Search

2017-03-01

The emergence of natural gas as an abundant, inexpensive fuel in the United States has highlighted the possibility that natural gas could play a significant role in the transition to low carbon fuels. Natural gas is often cited as a bridge to l...

Inactivation of the Anterior Cingulate Cortex Impairs Extinction of Rabbit Jaw Movement Conditioning and Prevents Extinction-Related Inhibition of Hippocampal Activity

ERIC Educational Resources Information Center

Griffin, Amy L.; Berry, Stephen D.

2004-01-01

Although past research has highlighted the involvement of limbic structures such as the anterior cingulate cortex (ACC) and hippocampus in learning, few have addressed the nature of their interaction. The current study of rabbit jaw movement conditioning used a combination of reversible lesions and electrophysiology to examine the involvement of…

Effects of Child Psychopathology on Maternal Depression: The Mediating Role of Child-Related Acute and Chronic Stressors

ERIC Educational Resources Information Center

Raposa, Elizabeth B.; Hammen, Constance L.; Brennan, Patricia A.

2011-01-01

In light of recent research highlighting the potential effects of children's behavior on mothers' mental health, the current study examined 679 mothers and their adolescent children from a community-based sample to determine the effects of youth psychopathology on maternal depression and levels of child-related stress in mothers' lives. It was…

Drugs and the Nation's High School Students: Five Year National Trends. 1979 Highlights.

ERIC Educational Resources Information Center

Johnston, Lloyd D.; And Others

The current prevalence of drug use among American high school seniors, and trends in drug use since 1975, were investigated as part of the program entitled "Monitoring the Future: A Continuing Study of the Lifestyles and Values of Youth," funded by the National Institute on Drug Abuse. The basic research design involved data collection from high…

A Cultural Communities Approach to Understanding Head Start Teachers' Beliefs about Language Use with Dual Language Learners: Implications for Practice

ERIC Educational Resources Information Center

Garrity, Sarah; Guerra, Alison Wishard

2015-01-01

The school-readiness gap for Latino dual language learners in the United States has been well documented, despite a strong research base highlighting effective strategies and practices for supporting their academic success. However, current educational practices reflect the hegemonic discourse that, because the United States is an English-speaking…

The Science Classroom as a Site of Epistemic Talk: A Case Study of a Teacher's Attempts to Teach Science Based on Argument

ERIC Educational Resources Information Center

Christodoulou, Andri; Osborne, Jonathan

2014-01-01

Current science education research and policy highlight the need to conceptualize scientific disciplines not only based on a view of "science-as-knowledge" but also on a perspective of "science-as-practice," placing an emphasis on practices such as explanation, argumentation, modeling, and communication. However, classroom…

108 Range Commanders Council Meteorology Group Meeting (RCC-MG) NASA Marshall Space Flight Center Range Report - April 2017

NASA Technical Reports Server (NTRS)

Roberts, Barry C.

2017-01-01

The following is a summary of the major meteorological/atmospheric projects and research that have been or currently are being accomplished at Marshall Space Flight Center (MSFC). Listed below are highlights of work done during the past 6 months in the Engineering Directorate (ED) and in the Science and Technology Office (ST).

The Fourth National Climate Assessment: Progress and Next Steps

NASA Astrophysics Data System (ADS)

Reidmiller, D.; Lewis, K.; Reeves, K.

2017-12-01

The Global Change Research Act of 1990 mandates the production of a quadrennial National Climate Assessment (NCA) that integrates, evaluates, and interprets global change science. The NCA analyzes observed and projected trends in global change and evaluates related impacts across a range of sectors and regions in the United States. The fourth assessment, NCA4, is currently under development by nearly 300 Federal and non-Federal experts and is expected to be available for public comment in Fall 2017 and released in late 2018. NCA4 is a key component of the US Global Change Research Program's Sustained Assessment process, which aims to advance the science of global change and provide authoritative, relevant information for decision makers. This talk will highlight the progress of NCA4, including an overview of the current draft of the assessment and advances since the third NCA, released in 2014. It will highlight the Climate Science Special Report, an essential component of NCA4, as well as provide insight into the public engagement process-including opportunities to participate-and identify scientific inputs and tools critical to its development, such as the 2nd State of the Carbon Cycle Report and USGCRP's new scenario products website.

Current Australian physiotherapy management of hip osteoarthritis.

PubMed

Cowan, Sallie M; Blackburn, Meagan S; McMahon, Kylie; Bennell, Kim L

2010-12-01

Symptomatic osteoarthritis can be a painful, costly and debilitating condition. Whilst there is a substantial body of literature surrounding osteoarthritis of the knee, there is less reported research on the hip joint, especially pertaining to physiotherapy intervention. This descriptive study aimed to describe current physiotherapy management of osteoarthritis of the hip by Australian physiotherapists in private practice and acute hospital settings. Cross-sectional survey. A questionnaire was administered to 364 public and private practitioners in the state of Victoria. A response rate of 66% was achieved. Physiotherapists working in the private and public sectors reported frequent use of manual therapy (78% and 87%, respectively), aquatic therapy (82% and 58%, respectively) and home exercise programmes (88% and 80%, respectively). Class-based physiotherapy is employed less frequently (44% and 28%, respectively). Strengthening exercises are the most common treatment technique. The widespread use of exercise and manual therapy in the management of osteoarthritis of the hip is highlighted. There was little difference in overall physiotherapy management between the public and private settings. The results identify interventions commonly used in clinical practice. The need for further research to evaluate the effectiveness of frequently used interventions is also highlighted. Copyright © 2010 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Internal anal sphincter: Clinical perspective.

PubMed

Kumar, Lalit; Emmanuel, Anton

2017-08-01

To summarise current knowledge of Internal anal sphincter. The internal anal sphincter (IAS) is the involuntary ring of smooth muscle in the anal canal and is the major contributor to the resting pressure in the anus. Structural injury or functional weakness of the muscle results in passive incontinence of faeces and flatus. With advent of new assessment and treatment modalities IAS has become an important topic for surgeons. This review was undertaken to summarise our current knowledge of internal anal sphincter and highlight the areas that need further research. The PubMed database was used to identify relevant studies relating to internal anal sphincter. The available evidence has been summarised and advantages and limitations highlighted for the different diagnostic and therapeutic techniques. Our understanding of the physiology and pharmacology of IAS has increased greatly in the last three decades. Additionally, there has been a rise in diagnostic and therapeutic techniques specifically targeting the IAS. Although these are promising, future research is required before these can be incorporated into the management algorithm. Copyright © 2016 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilinskaya, Anna N.; Dobrovolskaia, Marina A., E-ma

Nanoparticle immunogenicity and antigenicity have been under investigation for many years. During the past decade, significant progress has been made in understanding what makes a nanoparticle immunogenic, how immune cells respond to nanoparticles, what consequences of nanoparticle-specific antibody formation exist and how they challenge the application of nanoparticles for drug delivery. Moreover, it has been recognized that accidental contamination of therapeutic protein formulations with nanosized particulate materials may contribute to the immunogenicity of this type of biotechnology products. While the immunological properties of engineered nanomaterials and their application as vaccine carriers and adjuvants have been given substantial consideration in themore » current literature, little attention has been paid to nanoparticle immuno- and antigenicity. To fill in this gap, we herein provide an overview of this subject to highlight the current state of the field, review past and present research, and discuss future research directions. - Highlights: • Most engineered nanomaterials are not immunogenic per se. • Generation of nanoparticle-specific antibody can be T-cell dependent or independent. • Antibodies can be generated to particle core, terminal groups or surface coatings. • Engineered and accidental nanomaterials have distinct contribution to immunogenicity. • Tunable physicochemical properties make each nanoparticle unique.« less

Condensed Matter Physics at ONR - A Nanoelectronics Perspective

NASA Astrophysics Data System (ADS)

Baatar, Chagaan

As a mission agency within the Department of Defense, the Office of Naval Research (ONR) currently does not have a program exclusively dedicated to condensed matter physics (CMP) research. Yet many CMP related topics are being funded under various programs scattered throughout the agency. In this talk I will provide an example of such a program - the ONR Nanoelectronics program, that I currently manage, and highlight some of the CMP related activities within the program. I may also mention a few topics that are funded by other ONR program officers. Finally, in addressing the theme of the session, I will describe the ONR Young Investigator Program (YIP) - its brief history, solicitation and evaluation processes involved, and provide a few examples from recent YIP projects.

[AIDS and pauperization: principal concepts and empirical evidence].

PubMed

Bastos, F I; Szwarcwald, C L

2000-01-01

This paper discusses methodologies for analyzing relations between social inequalities, marginalization, prejudice, and vulnerability to HIV/AIDS, highlighting current difficulties and alternative research strategies. It also reviews the international and Brazilian literature, emphasizing: economic and macropolitical dimensions in the spread of HIV/AIDS; the role of drug policies and consumption; gender inequalities and prejudice; racial/ethnic inequalities and prejudice; and interaction with other STIs and their relationship to poverty; HIV/AIDS and health care standards, especially access to antiretroviral therapy; and human rights violations. Despite current methodological dilemmas in analyzing relations between psychosocial, cultural, and sociopolitical variables and vulnerability to HIV/AIDS and the limited Brazil literature, such themes merit further investigation, addressing Brazilian social and cultural specificities and profiting from recently developed research strategies.

Biomedical wellness challenges and opportunities

NASA Astrophysics Data System (ADS)

Tangney, John F.

2012-06-01

The mission of ONR's Human and Bioengineered Systems Division is to direct, plan, foster, and encourage Science and Technology in cognitive science, computational neuroscience, bioscience and bio-mimetic technology, social/organizational science, training, human factors, and decision making as related to future Naval needs. This paper highlights current programs that contribute to future biomedical wellness needs in context of humanitarian assistance and disaster relief. ONR supports fundamental research and related technology demonstrations in several related areas, including biometrics and human activity recognition; cognitive sciences; computational neurosciences and bio-robotics; human factors, organizational design and decision research; social, cultural and behavioral modeling; and training, education and human performance. In context of a possible future with automated casualty evacuation, elements of current science and technology programs are illustrated.

The trials and tribulations of a practitioner-researcher: challenges and lessons learned through testing a feminist-cognitive-relational social work model of practice.

PubMed

Dombo, Eileen A; Bass, Ami P

2014-01-01

In practice with adult women who survived childhood sexual abuse, the field of social work currently lacks an evidence-based intervention. The current interventions, from the 1990s, come primarily from psychologists. The hypothesis that the Feminist-Cognitive-Relational Social Work Model and Intervention will be more effective in decreasing cognitive distortions, and increasing intimacy and relational health when compared to the standard agency intervention was tested in a quasi-experimental study. The challenges in carrying out the study in small, non-profit organizations are explored to highlight the difficulties in developing evidence-based interventions. Changes to implementation that resulted from the research findings are discussed.

An Overview of the Current Understanding of Gamma-Ray Bursts in the Fermi Era

NASA Technical Reports Server (NTRS)

Bhat, P. N.; Guiriec, Sylvain

2011-01-01

Gamma-ray bursts are the most luminous explosions in the Universe, and their origin as well as mechanism are the focus of intense research and debate. More than three decades since their serendipitous discovery, followed by several breakthroughs from space-borne and ground-based observations, they remain one of the most interesting astrophysical phenomena yet to be completely understood. Since the launch of Fermi with its unprecedented energy band width spanning seven decades, the study of gamma-ray burst research has entered a new phase. Here we review the current theoretical understanding and observational highlights of gamma-ray burst astronomy and point out some of the potential promises of multi-wavelength observations in view of the upcoming ground based observational facilities .

The impact of perception and presence on emotional reactions: a review of research in virtual reality

PubMed Central

Diemer, Julia; Alpers, Georg W.; Peperkorn, Henrik M.; Shiban, Youssef; Mühlberger, Andreas

2015-01-01

Virtual reality (VR) has made its way into mainstream psychological research in the last two decades. This technology, with its unique ability to simulate complex, real situations and contexts, offers researchers unprecedented opportunities to investigate human behavior in well controlled designs in the laboratory. One important application of VR is the investigation of pathological processes in mental disorders, especially anxiety disorders. Research on the processes underlying threat perception, fear, and exposure therapy has shed light on more general aspects of the relation between perception and emotion. Being by its nature virtual, i.e., simulation of reality, VR strongly relies on the adequate selection of specific perceptual cues to activate emotions. Emotional experiences in turn are related to presence, another important concept in VR, which describes the user’s sense of being in a VR environment. This paper summarizes current research into perception of fear cues, emotion, and presence, aiming at the identification of the most relevant aspects of emotional experience in VR and their mutual relations. A special focus lies on a series of recent experiments designed to test the relative contribution of perception and conceptual information on fear in VR. This strand of research capitalizes on the dissociation between perception (bottom–up input) and conceptual information (top-down input) that is possible in VR. Further, we review the factors that have so far been recognized to influence presence, with emotions (e.g., fear) being the most relevant in the context of clinical psychology. Recent research has highlighted the mutual influence of presence and fear in VR, but has also traced the limits of our current understanding of this relationship. In this paper, the crucial role of perception on eliciting emotional reactions is highlighted, and the role of arousal as a basic dimension of emotional experience is discussed. An interoceptive attribution model of presence is suggested as a first step toward an integrative framework for emotion research in VR. Gaps in the current literature and future directions are outlined. PMID:25688218

The impact of perception and presence on emotional reactions: a review of research in virtual reality.

PubMed

Diemer, Julia; Alpers, Georg W; Peperkorn, Henrik M; Shiban, Youssef; Mühlberger, Andreas

2015-01-01

Virtual reality (VR) has made its way into mainstream psychological research in the last two decades. This technology, with its unique ability to simulate complex, real situations and contexts, offers researchers unprecedented opportunities to investigate human behavior in well controlled designs in the laboratory. One important application of VR is the investigation of pathological processes in mental disorders, especially anxiety disorders. Research on the processes underlying threat perception, fear, and exposure therapy has shed light on more general aspects of the relation between perception and emotion. Being by its nature virtual, i.e., simulation of reality, VR strongly relies on the adequate selection of specific perceptual cues to activate emotions. Emotional experiences in turn are related to presence, another important concept in VR, which describes the user's sense of being in a VR environment. This paper summarizes current research into perception of fear cues, emotion, and presence, aiming at the identification of the most relevant aspects of emotional experience in VR and their mutual relations. A special focus lies on a series of recent experiments designed to test the relative contribution of perception and conceptual information on fear in VR. This strand of research capitalizes on the dissociation between perception (bottom-up input) and conceptual information (top-down input) that is possible in VR. Further, we review the factors that have so far been recognized to influence presence, with emotions (e.g., fear) being the most relevant in the context of clinical psychology. Recent research has highlighted the mutual influence of presence and fear in VR, but has also traced the limits of our current understanding of this relationship. In this paper, the crucial role of perception on eliciting emotional reactions is highlighted, and the role of arousal as a basic dimension of emotional experience is discussed. An interoceptive attribution model of presence is suggested as a first step toward an integrative framework for emotion research in VR. Gaps in the current literature and future directions are outlined.

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice

PubMed Central

Al-Himdani, Sarah; Jessop, Zita M.; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H.; Hart, Andrew M.; Archer, Charles W.; Thornton, Catherine A.; Whitaker, Iain S.

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering “holds the promise of revolutionizing patient care in the twenty-first century.” The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20–30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions. PMID:28280722

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice.

PubMed

Al-Himdani, Sarah; Jessop, Zita M; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H; Hart, Andrew M; Archer, Charles W; Thornton, Catherine A; Whitaker, Iain S

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering "holds the promise of revolutionizing patient care in the twenty-first century." The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20-30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions.

Violence Against Women in Cambodia: Towards a Culturally Responsive Theory of Change.

PubMed

Eisenbruch, Maurice

2018-06-01

Almost one in four women in Cambodia is a victim of physical, emotional or sexual violence. This article brings together two seldom connected fields: Theory of Change (ToC) and cultural responsiveness in international development. It applies these approaches to a priority in global health, which is to prevent violence against women (VAW) and, drawing on my research on the epigenesis of VAW in Cambodia, develops an argument on the need for interventions to work with tradition and culture rather than only highlight it in problematic terms. The research draws on an ethnographic study carried out in Cambodia with 102 perpetrators and survivors of emotional, physical and sexual VAW and 228 key informants from the Buddhist and healing sectors. The eight 'cultural attractors' identified in the author's prior research highlight the cultural barriers to acceptance of the current Theory of Change. ToC for VAW prevention in Cambodia seems to assume that local culture promotes VAW and that men and women must be educated to eradicate the traditional gender norms. There is a need for interventions to work with tradition and culture rather than only highlight it in problematic terms. The cultural epigenesis of VAW in Cambodia is an insight which can be used to build culturally responsive interventions and strengthen the primary prevention of VAW.

Recognizing the value of assistance dogs in society.

PubMed

Audrestch, Hilary M; Whelan, Chantelle T; Grice, David; Asher, Lucy; England, Gary C W; Freeman, Sarah L

2015-10-01

Assistance dogs are specially trained to undertake a variety of tasks to help individuals with disabilities. This review gives an overview of the different types of assistance dogs in the UK, including guide dogs, hearing dogs, mobility assistance dogs, service dogs and dual-purpose dogs. The literature describes many benefits of assistance dogs, including their impact on physical wellbeing and safety of their 'owners,' as well as on psychological wellbeing and social inclusion. The role of assistance dogs in society is widely recognized by the public, but is not currently acknowledged in government social policy. The current evidence on the benefits of assistance dogs is limited by the type and scale of current research. This article highlights the need for independent funding for high quality research to enable social care and policy makers to make evidence-based decisions on the value of assistance dogs to people with disabilities. Copyright © 2015 Elsevier Inc. All rights reserved.

Examining the Relationship Between Intimate Partner Violence and Concern for Animal Care and Safekeeping.

PubMed

Wuerch, Melissa A; Giesbrecht, Crystal J; Price, Jill A B; Knutson, Tracy; Wach, Frances

2017-03-01

The current study examined the knowledge and experience of animal welfare and human service providers in urban and rural communities of Saskatchewan, Canada. Nine exploratory qualitative interviews were conducted to gather a more in-depth understanding of whether the concern for animal care and safekeeping impacts the decision to leave situations of intimate partner violence. The interviews were semistructured and guided by four questions, which were designed, reviewed, and revised based on feedback from a community-based research team. Thematic analysis highlighted important findings, allowing for the generation of suggestions for improvement of current supports and services offered. The current study findings suggest that concern for animal care and safekeeping creates significant barriers regarding the decision to leave situations of intimate partner violence and abuse, warranting further research to inform support services and resources within a Canadian context.

Transcranial Direct Current Stimulation (tDCS): A Beginner's Guide for Design and Implementation

PubMed Central

Thair, Hayley; Holloway, Amy L.; Newport, Roger; Smith, Alastair D.

2017-01-01

Transcranial direct current stimulation (tDCS) is a popular brain stimulation method that is used to modulate cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviors. There is, however, a current lack of consensus between studies, with many results suggesting that polarity-specific effects are difficult to obtain. This article explores some of these differences and highlights the experimental parameters that may underlie their occurrence. We provide a general, practical snapshot of tDCS methodology, including what it is used for, how to use it, and considerations for designing an effective and safe experiment. Our aim is to equip researchers who are new to tDCS with the essential knowledge so that they can make informed and well-rounded decisions when designing and running successful experiments. By summarizing the varied approaches, stimulation parameters, and outcomes, this article should help inform future tDCS research in a variety of fields. PMID:29213226

State of the Science of Spirituality and Palliative Care Research Part I: Definitions, Measurement, and Outcomes.

PubMed

Steinhauser, Karen E; Fitchett, George; Handzo, George F; Johnson, Kimberly S; Koenig, Harold G; Pargament, Kenneth I; Puchalski, Christina M; Sinclair, Shane; Taylor, Elizabeth J; Balboni, Tracy A

2017-09-01

The State of the Science in Spirituality and Palliative Care was convened to address the current landscape of research at the intersection of spirituality and palliative care and to identify critical next steps to advance this field of inquiry. Part I of the SOS-SPC two-part series focuses on questions of 1) What is spirituality? 2) What methodological and measurement issues are most salient for research in palliative care? And 3) What is the evidence relating spirituality and health outcomes? After describing current evidence we make recommendations for future research in each of the three areas of focus. Results show wide variance in the ways spirituality is operationalized and the need for definition and conceptual clarity in research in spirituality. Furthermore, the field would benefit from hypothesis-driven outcomes research based on a priori specification of the spiritual dimensions under investigation and their longitudinal relationship with key palliative outcomes, the use of validated measures of predictors and outcomes, and rigorous assessment of potential confounding variables. Finally, results highlight the need for research in more diverse populations. Published by Elsevier Inc.

Toward an occupational rehabilitation policy community for cancer survivors in Singapore: a stakeholder perspective from the SME employers.

PubMed

Mak, Angela Ka Ying

2011-03-01

Cancer and return to work has been extensively studied in the Western context and yet it has not received much academic attention in Asia. This paper aims to review the current Singapore government rehabilitation initiatives in collaboration with the policy community, identify the socio-environmental barriers to implementing the existing programs for cancer survivors, highlights the demand-side of research development and illustrates the viewpoints of small and medium enterprise employers in Singapore from a recent study. Implications and future directions in developing evidence-based rehabilitation policies and initiatives for cancer survivors in Singapore and the Southeast Asian region are also discussed. A review of occupational rehabilitation literature relevant to Singapore looking at legislation, policies, initiatives and services was performed. Current state-of-art research in occupational rehabilitation from an employer perspective was also synthesized. Challenges and barriers of adopting the current rehabilitation initiatives and programs for cancer survivors exist largely due to the lack of centralized effort, clear definitions and understanding between people with disabilities, chronic illness and cancer as well as an evidence-based policy community. In addition, too much emphasis on new hiring than retaining in current services and there are no specific guidelines to help employers deal with issues when retaining employees with health history, such as workplace accommodation, appraisal, discrimination and grievance handling. Palpable blind spots in the current occupational rehabilitation system and policy were highlighted in this paper. Coupled with systemic improvements, continuous government resource support and developing an evidence-based policy community between the government, employers, healthcare professionals, industry and community partners and non-profit organizations, a positive change of the rehabilitation initiatives and services is promising.

Trespassing on the tracks: a review of railway pedestrian safety research.

PubMed

Lobb, Brenda

2006-01-01

Train-pedestrian collisions have been shown to be the leading cause of fatality in train-related accidents worldwide, yet there is remarkably little research in this area. In this paper, the major types of railway transportation accident research are briefly highlighted to indicate the general context of research concerning train-pedestrian collisions, which are then reviewed. Themes emerging from the diverse research are identified, the various strategies that have been proposed for prevention of railway pedestrian accidents are discussed, and the empirical evidence for their efficacy examined in the light of the much more extensive literature on road pedestrian accidents. Finally, it is proposed that application of current theory in behavioral and cognitive psychology may usefully inform future research in transportation safety.

Biomass burning in Indo-China peninsula and its impacts on regional air quality and global climate change-a review.

PubMed

Yadav, Ishwar Chandra; Linthoingambi Devi, Ningombam; Li, Jun; Syed, Jabir Hussain; Zhang, Gan; Watanabe, Hirozumi

2017-08-01

Although, many biomass burning (BB) emissions products (particulate matter and trace gases) are believed to be trans-boundary pollutants that originates from India and China (the two most populous countries in Asia), the information about BB emission and related contents is limited for Indo-China Peninsula (ICP) region. This motivated us to review this region pertaining to BB emission. The main objective of the review is to document the current status of BB emission in ICP region. In order to highlight the impact of BB on regional air quality and global climate change, the role of BB emission in ICP region is also discussed. Based on the available literature and modeling simulations studies, it is evidenced that ICP is one of the hotspot regional source for aerosols in terms of BB emissions. In addition, regional emissions through BB have significant implications for regional air quality especially in the neighboring countries such as China, Taiwan and India. Our assessment highlight that there is still a general lack of reliable data and research studies addressing BB related issues in context of environmental and human health. There is therefore a critical need to improve the current knowledge base, which should build upon the research experience and further research into these issues is considered vital to help inform future policies/control strategies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Research highlights: increasing paper possibilities.

PubMed

Wu, Chueh-Yu; Adeyiga, Oladunni; Lin, Jonathan; Di Carlo, Dino

2014-09-07

In this issue we highlight three recent papers that demonstrate new strategies to extend the capabilities of paper microfluidics. Paper (a mesh of porous fibers) has a long history as a substrate to perform biomolecular assays. Traditional lateral flow immunoassays (LFAs) are widely used for rapid diagnostic tests, and perform well when a yes or no answer is required and the analyte of interest is at relatively high concentrations. High concentrations are required because usually only a small volume of analyte-containing fluid flows past the detection region, leading to a limited signal. Further, the small pores within paper matrices prevent the use of paper to control the flow of larger particles and cells, limiting the use of paper microfluidics for cell-based diagnostics. The work we highlight addresses these important unmet challenges in paper microfluidics: enriching low concentration analytes to a higher concentration in a smaller volume that can be processed effectively, and using paper to pump flows in larger channels amenable to cells. Applying these new approaches may allow diagnosis of disease states currently technically unachievable using current LFA systems, while maintaining many of the "un-instrumented" advantages of an assay on self-wicking paper.

Criminalising consensual sexual behaviour in the context of HIV: consequences, evidence, and leadership.

PubMed

Ahmed, Aziza; Kaplan, Margo; Symington, Alison; Kismodi, Eszter

2011-01-01

This paper provides an overview of the use of the criminal law to regulate sexual behaviour in three areas of critical importance: (1) HIV exposure in otherwise consensual sex, (2) sex work and (3) sexual activity largely affecting sexual minorities. It analyses criminal law pertaining to these three distinct areas together, allowing for a more comprehensive and cohesive understanding of criminalisation and its effects. The paper highlights current evidence of how criminalisation undermines HIV prevention and treatment. It focuses on three specific negative effects of criminalisation: (1) enhancing stigma and discrimination, (2) undermining public health intervention through legal marginalisation and (3) placing people in state custody. The paper also highlights gaps in evidence and the need for strong institutional leadership from UN agencies in ending the criminalisation of consensual sexual activity. This paper serves two goals: (1) highlighting the current state of research and emphasising where key institutions have or have not provided appropriate leadership on these issues and (2) establishing a forward-looking agenda that includes a concerted response to the inappropriate use of the criminal law with respect to sexuality as part of the global response to HIV.

Using Behavior Sequence Analysis to Map Serial Killers' Life Histories.

PubMed

Keatley, David A; Golightly, Hayley; Shephard, Rebecca; Yaksic, Enzo; Reid, Sasha

2018-03-01

The aim of the current research was to provide a novel method for mapping the developmental sequences of serial killers' life histories. An in-depth biographical account of serial killers' lives, from birth through to conviction, was gained and analyzed using Behavior Sequence Analysis. The analyses highlight similarities in behavioral events across the serial killers' lives, indicating not only which risk factors occur, but the temporal order of these factors. Results focused on early childhood environment, indicating the role of parental abuse; behaviors and events surrounding criminal histories of serial killers, showing that many had previous convictions and were known to police for other crimes; behaviors surrounding their murders, highlighting differences in victim choice and modus operandi; and, finally, trial pleas and convictions. The present research, therefore, provides a novel approach to synthesizing large volumes of data on criminals and presenting results in accessible, understandable outcomes.

A human rights approach to advocacy for people with dementia: A review of current provision in England and Wales.

PubMed

Dixon, Jeremy; Laing, Judy; Valentine, Christine

2018-01-01

In this article, we review current advocacy services for people with dementia in England and Wales (provided, respectively, under the Mental Capacity Act 2005 , the Mental Health Act 1983 /2007 and the Care Act 2014) through the lens of the United Nations Convention on the Rights of Persons with Disabilities (CRPD). We examine what a human rights' approach to advocacy support would entail, and whether current frameworks in England and Wales are adequate for this approach and provide a sufficient safeguard. First, we consider how the human rights of persons with dementia have become increasingly important and the extent to which the CRPD provides an opportunity to bolster safeguards and protection. Second, we discuss cause and case advocacy, and how these advocacy models could be shaped by the CRPD to promote the rights of persons with dementia at each stage of the disease. Third, we highlight current dilemmas and challenges in the provision of advocacy support in England and Wales by focusing on case law, commissioning of services and current practice. In particular, we analyse how the different legislative schemes have given rise to some confusion about the various advocacy provisions, as well as potential for overlap and discrepancies between different regimes. We also highlight the need for further research to address important gaps in knowledge, including the scale of need, patterns of referral and attitudes to advocacy services. The article concludes by highlighting how advocacy support could be recalibrated as a universal right to promote the aims and aspirations of the CRPD, and how education is needed to address the stigma of dementia and promote the benefits of advocacy in protecting the rights of those with dementia.

Information Needs Assessment for Coastal and Marine Management and Policy: Ecosystem Services Under Changing Climatic, Land Use, and Demographic Conditions.

PubMed

Goldsmith, Kaitlin A; Granek, Elise F; Lubitow, Amy

2015-12-01

Changing climatic, demographic, and land use conditions are projected to alter the provisioning of ecosystem services in estuarine, coastal, and nearshore marine ecosystems, necessitating mitigation and adaptation policies and management. The current paradigm of research efforts occurring in parallel to, rather than in collaboration with, decision makers will be insufficient for the rapid responses required to adapt to and mitigate for projected changing conditions. Here, we suggest a different paradigm: one where research begins by engaging decision makers in the identification of priority data needs (biophysical, economic, and social). This paper uses synthesized interview data to provide insight into the varied demands for scientific research as described by decision makers working on coastal issues in Oregon, USA. The findings highlight the need to recognize (1) the differing framing of ecosystem services by decision makers versus scientists; and (2) the differing data priorities relevant to inland versus coastal decision makers. The findings further serve to highlight the need for decision makers, scientists, and funders to engage in increased communication. This research is an important first step in advancing efforts toward evidence-based decision making in Oregon and provides a template for further research across the US.

Environmental application of biochar: Current status and perspectives.

PubMed

Oliveira, Fernanda R; Patel, Anil K; Jaisi, Deb P; Adhikari, Sushil; Lu, Hui; Khanal, Samir Kumar

2017-12-01

In recent years, there has been a significant interest on biochar for various environmental applications, e.g., pollutants removal, carbon sequestration, and soil amelioration. Biochar has several unique properties, which makes it an efficient, cost-effective and environmentally-friendly material for diverse contaminants removal. The variability in physicochemical properties (e.g., surface area, microporosity, and pH) provides an avenue for biochar to maximize its efficacy to targeted applications. This review aims to highlight the vital role of surface architecture of biochar in different environmental applications. Particularly, it provides a critical review of current research updates related to the pollutants interaction with surface functional groups of biochars and the effect of the parameters variability on biochar attributes pertinent to specific pollutants removal, involved mechanisms, and competence for these removals. Moreover, future research directions of biochar research are also discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

Institute of Geophysics and Planetary Physics (IGPP), Lawrence Livermore National Laboratory (LLNL): Quinquennial report, November 14-15, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tweed, J.

1996-10-01

This Quinquennial Review Report of the Lawrence Livermore National Laboratory (LLNL) branch of the Institute for Geophysics and Planetary Physics (IGPP) provides an overview of IGPP-LLNL, its mission, and research highlights of current scientific activities. This report also presents an overview of the University Collaborative Research Program (UCRP), a summary of the UCRP Fiscal Year 1997 proposal process and the project selection list, a funding summary for 1993-1996, seminars presented, and scientific publications. 2 figs., 3 tabs.

Do Increasingly Globalized Land Systems Promote or Undermine Sustainability?

NASA Astrophysics Data System (ADS)

Munroe, D. K.

2015-12-01

Scholars are now studying land systems in a global context using such concepts as "telecoupling." Research to date has recognized that local land systems may be undermined by globalization, and local people displaced. The land change community emphasizes the ways in which local people make decisions about natural resources given the opportunities and constraints that globalization presents. This talk will present a summary of current land systems science research in agribusiness, global trade and financial institutions, highlighting key ways in which sustainability measures can capture the effects of these actors and activities.

Current research on pharmacologic and regenerative therapies for osteoarthritis

PubMed Central

Zhang, Wei; Ouyang, Hongwei; Dass, Crispin R; Xu, Jiake

2016-01-01

Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical practice, and is the leading cause of disability in elderly people. Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers, OA is a challenging disease with limited treatment options. Traditional pharmacologic therapies such as acetaminophen, non-steroidal anti-inflammatory drugs, and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events. Current research focuses on the development of new OA drugs (such as sprifermin/recombinant human fibroblast growth factor-18, tanezumab/monoclonal antibody against β-nerve growth factor), which aims for more effectiveness and less incidence of adverse effects than the traditional ones. Furthermore, regenerative therapies (such as autologous chondrocyte implantation (ACI), new generation of matrix-induced ACI, cell-free scaffolds, induced pluripotent stem cells (iPS cells or iPSCs), and endogenous cell homing) are also emerging as promising alternatives as they have potential to enhance cartilage repair, and ultimately restore healthy tissue. However, despite currently available therapies and research advances, there remain unmet medical needs in the treatment of OA. This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. PMID:26962464

Highlights of Conference on Using Student Test Scores to Measure Teacher Performance: The State of the Art in Research and Practice

ERIC Educational Resources Information Center

Guarino, Cassandra; Reckase, Mark D.; Wooldridge, Jeffrey M.

2013-01-01

The push for accountability in public schooling has extended to the measurement of teacher performance, accelerated by federal efforts through Race to the Top. Currently, a large number of states and districts across the country are computing measures of teacher performance based on the standardized test scores of their students and using them to…

Developmental Characteristics of Young Dual Language Learners: Implications for Policy and Practice in Infant and Toddler Care

ERIC Educational Resources Information Center

Castro, Dina C.; Espinosa, Linda M.

2014-01-01

This article discusses the current knowledge on the developmental characteristics and contexts of care for infants and toddlers who are growing up in bilingual environments at home and in their early care settings in the united States. The authors highlight relevant findings from the work of the Center of Early Care and Education Research-Dual…

Outreach and educational activities in Russia

NASA Astrophysics Data System (ADS)

Gritsevich, M.; Kartashova, A.

2012-09-01

We present an overview of the major internal as well as international meetings and events held in Russia and dedicated to the integration, development and expanding of knowledge in Planetary Research. The report is complemented by the Europlanet activities in Russia over the last year, achieved goals and lessons learned. Additionally, we highlight current problems and possible future improvements to the present educational and outreach techniques.

The hidden cost of wildfires: Economic valuation of health effects of wildfire smoke exposure in southern California

Treesearch

Leslie A. Richardson; Patricia A. Champ; John B. Loomis

2012-01-01

There is a growing concern that human health impacts from exposure to wildfire smoke are ignored in estimates of monetized damages from wildfires. Current research highlights the need for better data collection and analysis of these impacts. Using unique primary data, this paper quantifies the economic cost of health effects from the largest wildfire in Los Angeles...

Turkish EFL Academicians' Problems Concerning Translation Activities and Practices, Attitudes towards the Use of Online and Printed Translation Tools, and Suggestions for Quality Translation Practice

ERIC Educational Resources Information Center

Zengin, Bugra; Kacar, Isil Gunseli

2011-01-01

This mixed method research study aimed to highlight the problems of EFL academicians concerning their current translation practices, their attitudes towards the use of various translation tools, and offer suggestions for more quality translation practices. Seventy-three EFL academicians from three Turkish universities participated in the study.…

A Future with Hybrid Electric Propulsion Systems: A NASA Perspective

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

The presentation highlights a NASA perspective on Hybrid Electric Propulsion Systems for aeronautical applications. Discussed are results from NASA Advance Concepts Study for Aircraft Entering service in 2030 and beyond and the potential use of hybrid electric propulsion systems as a potential solution to the requirements for energy efficiency and environmental compatibility. Current progress and notional potential NASA research plans are presented.

Learning for Economic Self-Sufficiency: Constructing Pedagogies of Hope among Low-Income, Low-Literate Adults. Adult Education Special Topics: Theory, Research and Practice in LifeLong Learning

ERIC Educational Resources Information Center

Alfred, Mary V., Ed.

2010-01-01

In a most timely volume addressing many of the connections among current fiscal and employment crises to adult education, Learning for Economic Self-Sufficiency highlights the problems and challenges that low-literate adults encounter in various environments. Moreover, this book presents strategies for addressing the chronic illiteracy among…

Shame among people living with HIV: a literature review

PubMed Central

Bennett, David S.; Traub, Kerry; Mace, Lauren; Juarascio, Adrienne; O’Hayer, C. Virginia

2016-01-01

Shame is consistently associated with poor adjustment (e.g., depressive symptoms) among community samples but, surprisingly, has rarely been directly examined among people living with HIV/AIDS (PLWH). This limited research on shame is likely due, in part, to shame’s having been subsumed within measures of internalized stigma, an imprecise construct with varied definitions in the HIV literature. The current review summarizes research directly examining the correlates of shame among PLWH. Findings indicate that shame is associated with greater depressive symptoms, less healthcare utilization, and poorer physical health among PLWH. Directions for future research examining shame among PLWH are highlighted, including the need for more prospective research examining shame as a predictor of future adjustment. PMID:26296135

Overview of NASA Glenn Research Center Programs in Aero-Heat Transfer and Future Needs

NASA Technical Reports Server (NTRS)

Gaugler, Raymond E.

2002-01-01

This presentation concentrates on an overview of the NASA Glenn Research Center and the projects that are supporting Turbine Aero-Heat Transfer Research. The principal areas include the Ultra Efficient Engine Technology (UEET) Project, the Advanced Space Transportation Program (ASTP) Revolutionary Turbine Accelerator (RTA) Turbine Based Combined Cycle (TBCC) project, and the Propulsion & Power Base R&T - Smart Efficient Components (SEC), and Revolutionary Aeropropulsion Concepts (RAC) Projects. In addition, highlights are presented of the turbine aero-heat transfer work currently underway at NASA Glenn, focusing on the use of the Glenn-HT Navier- Stokes code as the vehicle for research in turbulence & transition modeling, grid topology generation, unsteady effects, and conjugate heat transfer.

An eye for discovery

PubMed Central

Stahl, Andreas; Smith, Lois E.H.

2010-01-01

Vision research has often led to significant advances in our understanding of biology. There has also been particular success in translating basic research in the eye into breakthrough clinical therapies that mark important milestones for ophthalmology and also for medical research. Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year 2006. Only two years later, successful transfer of the RPE65 gene into retinal pigment epithelium of patients with Leber congenital amaurosis was noted as one of the most important clinical applications of gene therapy. The articles in this Review series outline current developments in vision research and highlight its continued importance in ophthalmology and medicine. PMID:20811156

NASA LaRC Workshop on Guidance, Navigation, Controls, and Dynamics for Atmospheric Flight, 1993

NASA Technical Reports Server (NTRS)

Buttrill, Carey S. (Editor)

1993-01-01

This publication is a collection of materials presented at a NASA workshop on guidance, navigation, controls, and dynamics (GNC&D) for atmospheric flight. The workshop was held at the NASA Langley Research Center on March 18-19, 1993. The workshop presentations describe the status of current research in the GNC&D area at Langley over a broad spectrum of research branches. The workshop was organized in eight sessions: overviews, general, controls, military aircraft, dynamics, guidance, systems, and a panel discussion. A highlight of the workshop was the panel discussion which addressed the following issue: 'Direction of guidance, navigation, and controls research to ensure U.S. competitiveness and leadership in aerospace technologies.'

Toward a cognitive-affective model of goal-setting in rehabilitation: is self-regulation theory a key step?

PubMed

Siegert, Richard J; McPherson, Kathryn M; Taylor, William J

2004-10-21

The aim of this article is to argue that self-regulation theory might offer a useful model for clinical practice, theory-building and empirical research on goal-setting in rehabilitation. Relevant literature on goal-setting and motivation in rehabilitation is considered and some problematic issues for current practice and future research are highlighted. Carver and Scheier's self-regulation theory and its application to rehabilitation research is examined. It is argued that self-regulation theory offers a robust theoretical framework for goal-setting and one in which the salient concepts of motivation and emotion are prominent. Self-regulation theory offers a potentially useful heuristic framework for rehabilitation research.

Recent Investments by NASA's National Force Measurement Technology Capability

NASA Technical Reports Server (NTRS)

Commo, Sean A.; Ponder, Jonathan D.

2016-01-01

The National Force Measurement Technology Capability (NFMTC) is a nationwide partnership established in 2008 and sponsored by NASA's Aeronautics Evaluation and Test Capabilities (AETC) project to maintain and further develop force measurement capabilities. The NFMTC focuses on force measurement in wind tunnels and provides operational support in addition to conducting balance research. Based on force measurement capability challenges, strategic investments into research tasks are designed to meet the experimental requirements of current and future aerospace research programs and projects. This paper highlights recent and force measurement investments into several areas including recapitalizing the strain-gage balance inventory, developing balance best practices, improving calibration and facility capabilities, and researching potential technologies to advance balance capabilities.

Policies and practices of beach monitoring in the Great Lakes, USA: a critical review

USGS Publications Warehouse

Nevers, Meredith B.; Whitman, Richard L.

2010-01-01

Beaches throughout the Great Lakes are monitored for fecal indicator bacteria (typically Escherichia coli) in order to protect the public from potential sewage contamination. Currently, there is no universal standard for sample collection and analysis or results interpretation. Monitoring policies are developed by individual beach management jurisdictions, and applications are highly variable across and within lakes, states, and provinces. Extensive research has demonstrated that sampling decisions for time, depth, number of replicates, frequency of sampling, and laboratory analysis all influence the results outcome, as well as calculations of the mean and interpretation of the results in policy decisions. Additional shortcomings to current monitoring approaches include appropriateness and reliability of currently used indicator bacteria and the overall goal of these monitoring programs. Current research is attempting to circumvent these complex issues by developing new tools and methods for beach monitoring. In this review, we highlight the variety of sampling routines used across the Great Lakes and the extensive body of research that challenges comparisons among beaches. We also assess the future of Great Lakes monitoring and the advantages and disadvantages of establishing standards that are evenly applied across all beaches.

Toward a New Generation of Photonic Humidity Sensors

PubMed Central

Kolpakov, Stanislav A.; Gordon, Neil T.; Mou, Chengbo; Zhou, Kaiming

2014-01-01

This review offers new perspectives on the subject and highlights an area in need of further research. It includes an analysis of current scientific literature mainly covering the last decade and examines the trends in the development of electronic, acoustic and optical-fiber humidity sensors over this period. The major findings indicate that a new generation of sensor technology based on optical fibers is emerging. The current trends suggest that electronic humidity sensors could soon be replaced by sensors that are based on photonic structures. Recent scientific advances are expected to allow dedicated systems to avoid the relatively high price of interrogation modules that is currently a major disadvantage of fiber-based sensors. PMID:24577524

Theories of cognitive distortions in sexual offending: what the current research tells us.

PubMed

O Ciardha, Caoilte; Ward, Tony

2013-01-01

Cognitive distortions in sex offenders are specific or general beliefs/attitudes that violate commonly accepted norms of rationality that have been shown to be associated with the onset and maintenance of sexual offending. In this article, we describe the major theories that have been formulated to explain the role of distorted cognition in initiating and maintaining sexual offending. We evaluate each theory in light of a set of theory appraisal criteria and the available empirical research. Finally, we conclude by drawing together the results of this theory evaluation process and highlight the major implications for treatment and future research.

Women with disabilities' experience with physical and sexual abuse: review of the literature and implications for the field.

PubMed

Plummer, Sara-Beth; Findley, Patricia A

2012-01-01

While studies suggest that the rate of abuse of women with disabilities is similar or higher compared to the general population, there continues to be a lack of attention to this issue. Women with disabilities are at particularly high risk of abuse, both through typical forms of violence (physical, sexual, and emotional) and those that target one's disability. In an effort to highlight the need for increased attention to this issue, this article reviews the current peer-reviewed research in this field. The authors outline recommendations for future research goals and provide implications for research, practice, and policy.

In-flight simulation of high agility through active control: Taming complexity by design

NASA Technical Reports Server (NTRS)

Padfield, Gareth D.; Bradley, Roy

1993-01-01

The motivation for research into helicopter agility stems from the realization that marked improvements relative to current operational types are possible, yet there is a dearth of useful criteria for flying qualities at high performance levels. Several research laboratories are currently investing resources in developing second generation airborne rotorcraft simulators. The UK's focus has been the exploitation of agility through active control technology (ACT); this paper reviews the results of studies conducted to date. The conflict between safety and performance in flight research is highlighted and the various forms of safety net to protect against system failures are described. The role of the safety pilot, and the use of actuator and flight envelope limiting are discussed. It is argued that the deep complexity of a research ACT system can only be tamed through a requirement specification assembled using design principles and cast in an operational simulation form. Work along these lines conducted at DRA is described, including the use of the Jackson System Development method and associated Ada simulation.

Moral Emotions and Moral Behavior

PubMed Central

Stuewig, Jeff; Mashek, Debra J.

2011-01-01

Moral emotions represent a key element of our human moral apparatus, influencing the link between moral standards and moral behavior. This chapter reviews current theory and research on moral emotions. We first focus on a triad of negatively valenced “self-conscious” emotions—shame, guilt, and embarrassment. As in previous decades, much research remains focused on shame and guilt. We review current thinking on the distinction between shame and guilt, and the relative advantages and disadvantages of these two moral emotions. Several new areas of research are highlighted: research on the domain-specific phenomenon of body shame, styles of coping with shame, psychobiological aspects of shame, the link between childhood abuse and later proneness to shame, and the phenomena of vicarious or “collective” experiences of shame and guilt. In recent years, the concept of moral emotions has been expanded to include several positive emotions—elevation, gratitude, and the sometimes morally relevant experience of pride. Finally, we discuss briefly a morally relevant emotional process—other-oriented empathy. PMID:16953797

Moral emotions and moral behavior.

PubMed

Tangney, June Price; Stuewig, Jeff; Mashek, Debra J

2007-01-01

Moral emotions represent a key element of our human moral apparatus, influencing the link between moral standards and moral behavior. This chapter reviews current theory and research on moral emotions. We first focus on a triad of negatively valenced "self-conscious" emotions-shame, guilt, and embarrassment. As in previous decades, much research remains focused on shame and guilt. We review current thinking on the distinction between shame and guilt, and the relative advantages and disadvantages of these two moral emotions. Several new areas of research are highlighted: research on the domain-specific phenomenon of body shame, styles of coping with shame, psychobiological aspects of shame, the link between childhood abuse and later proneness to shame, and the phenomena of vicarious or "collective" experiences of shame and guilt. In recent years, the concept of moral emotions has been expanded to include several positive emotions-elevation, gratitude, and the sometimes morally relevant experience of pride. Finally, we discuss briefly a morally relevant emotional process-other-oriented empathy.

A Review of Norms and Normative Multiagent Systems

PubMed Central

Mahmoud, Moamin A.; Ahmad, Mohd Sharifuddin; Mustapha, Aida

2014-01-01

Norms and normative multiagent systems have become the subjects of interest for many researchers. Such interest is caused by the need for agents to exploit the norms in enhancing their performance in a community. The term norm is used to characterize the behaviours of community members. The concept of normative multiagent systems is used to facilitate collaboration and coordination among social groups of agents. Many researches have been conducted on norms that investigate the fundamental concepts, definitions, classification, and types of norms and normative multiagent systems including normative architectures and normative processes. However, very few researches have been found to comprehensively study and analyze the literature in advancing the current state of norms and normative multiagent systems. Consequently, this paper attempts to present the current state of research on norms and normative multiagent systems and propose a norm's life cycle model based on the review of the literature. Subsequently, this paper highlights the significant areas for future work. PMID:25110739

Exploring in teaching mode of Optical Fiber Sensing Technology outcomes-based education (OBE)

NASA Astrophysics Data System (ADS)

Fu, Guangwei; Fu, Xinghu; Zhang, Baojun; Bi, Weihong

2017-08-01

Combining with the characteristics of disciplines and OBE mode, also aiming at the phenomena of low learning enthusiasm for the major required courses for senior students, the course of optical fiber sensing was chosen as the demonstration for the teaching mode reform. In the light of "theory as the base, focus on the application, highlighting the practice" principle, we emphasis on the introduction of the latest scientific research achievements and current development trends, highlight the practicability and practicality. By observation learning and course project, enables students to carry out innovative project design and implementation means related to the practical problems in science and engineering of this course.

EUReKA! A Conceptual Model of Emotion Understanding

PubMed Central

Castro, Vanessa L.; Cheng, Yanhua; Halberstadt, Amy G.; Grühn, Daniel

2015-01-01

The field of emotion understanding is replete with measures, yet lacks an integrated conceptual organizing structure. To identify and organize skills associated with the recognition and knowledge of emotions, and to highlight the focus of emotion understanding as localized in the self, in specific others, and in generalized others, we introduce the conceptual framework of Emotion Understanding in Recognition and Knowledge Abilities (EUReKA). We then categorize fifty-six existing methods of emotion understanding within this framework to highlight current gaps and future opportunities in assessing emotion understanding across the lifespan. We hope the EUReKA model provides a systematic and integrated framework for conceptualizing and measuring emotion understanding for future research. PMID:27594904

A Primer on Observational Measurement.

PubMed

Girard, Jeffrey M; Cohn, Jeffrey F

2016-08-01

Observational measurement plays an integral role in a variety of scientific endeavors within biology, psychology, sociology, education, medicine, and marketing. The current article provides an interdisciplinary primer on observational measurement; in particular, it highlights recent advances in observational methodology and the challenges that accompany such growth. First, we detail the various types of instrument that can be used to standardize measurements across observers. Second, we argue for the importance of validity in observational measurement and provide several approaches to validation based on contemporary validity theory. Third, we outline the challenges currently faced by observational researchers pertaining to measurement drift, observer reactivity, reliability analysis, and time/expense. Fourth, we describe recent advances in computer-assisted measurement, fully automated measurement, and statistical data analysis. Finally, we identify several key directions for future observational research to explore.

Dengue: Knowledge gaps, unmet needs and research priorities

PubMed Central

Katzelnick, Leah C.; Coloma, Josefina; Harris, Eva

2018-01-01

Summary Dengue virus (DENV) is a mosquito-borne pathogen that causes up to ~100 million dengue cases each year, placing a major public health, social and economic burden on numerous low- and middle-income countries (LMICs). Major advances by scientists, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools. We discuss existing approaches to dengue diagnostics, disease prognosis, surveillance, and vector control in LMICs as well as potential consequences of vaccine introduction. We also summarize current knowledge and recent insights into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding natural infection and current and future vaccines. PMID:28185868

The role of simulation in teaching pediatric resuscitation: current perspectives

PubMed Central

Lin, Yiqun; Cheng, Adam

2015-01-01

The use of simulation for teaching the knowledge, skills, and behaviors necessary for effective pediatric resuscitation has seen widespread growth and adoption across pediatric institutions. In this paper, we describe the application of simulation in pediatric resuscitation training and review the evidence for the use of simulation in neonatal resuscitation, pediatric advanced life support, procedural skills training, and crisis resource management training. We also highlight studies supporting several key instructional design elements that enhance learning, including the use of high-fidelity simulation, distributed practice, deliberate practice, feedback, and debriefing. Simulation-based training is an effective modality for teaching pediatric resuscitation concepts. Current literature has revealed some research gaps in simulation-based education, which could indicate the direction for the future of pediatric resuscitation research. PMID:25878517

Impact of the Diamond Light Source on research in Earth and environmental sciences: current work and future perspectives

PubMed Central

Burke, Ian T.; Mosselmans, J. Frederick W.; Shaw, Samuel; Peacock, Caroline L.; Benning, Liane G.; Coker, Victoria S.

2015-01-01

Diamond Light Source Ltd celebrated its 10th anniversary as a company in December 2012 and has now accepted user experiments for over 5 years. This paper describes the current facilities available at Diamond and future developments that enhance its capacities with respect to the Earth and environmental sciences. A review of relevant research conducted at Diamond thus far is provided. This highlights how synchrotron-based studies have brought about important advances in our understanding of the fundamental parameters controlling highly complex mineral–fluid–microbe interface reactions in the natural environment. This new knowledge not only enhances our understanding of global biogeochemical processes, but also provides the opportunity for interventions to be designed for environmental remediation and beneficial use. PMID:25624516

Animal Study Registries: Results from a Stakeholder Analysis on Potential Strengths, Weaknesses, Facilitators, and Barriers.

PubMed

Wieschowski, Susanne; Silva, Diego S; Strech, Daniel

2016-11-01

Publication bias in animal research, its extent, its predictors, and its potential countermeasures are increasingly discussed. Recent reports and conferences highlight the potential strengths of animal study registries (ASRs) in this regard. Others have warned that prospective registration of animal studies could diminish creativity, add administrative burdens, and complicate intellectual property issues in translational research. A literature review and 21 international key-informant interviews were conducted and thematically analyzed to develop a comprehensive matrix of main- and subcategories for potential ASR-related strengths, weaknesses, facilitators, and barriers (SWFBs). We identified 130 potential SWFBs. All stakeholder groups agreed that ASRs could in various ways improve the quality and refinement of animal studies while allowing their number to be reduced, as well as supporting meta-research on animal studies. However, all stakeholder groups also highlighted the potential for theft of ideas, higher administrative burdens, and reduced creativity and serendipity in animal studies. Much more detailed reasoning was captured in the interviews than is currently found in the literature, providing a comprehensive account of the issues and arguments around ASRs. All stakeholder groups highlighted compelling potential strengths of ASRs. Although substantial weaknesses and implementation barriers were highlighted as well, different governance measures might help to minimize or even eliminate their impact. Such measures might include confidentiality time frames for accessing prospectively registered protocols, harmonized reporting requirements across ASRs, ethics reviews, lab notebooks, and journal submissions. The comprehensive information gathered in this study could help to guide a more evidence-based debate and to design pilot tests for ASRs.

Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology.

PubMed

Speck, Nicole E; Schuurmans, Macé M; Murer, Christian; Benden, Christian; Huber, Lars C

2016-06-21

Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of the cell profiles of bronchoalveolar lavage and plasma samples during acute lung allograft rejection. The value of these cells and changes within the pattern of differential cytology to support the diagnosis of acute lung allograft rejection is discussed. Current findings on the topic are highlighted and trends for future research are identified.

Understanding and treatment of chronic pancreatitis.

PubMed

Drewes, Asbjørn Mohr

2013-11-14

Chronic pancreatitis is characterized by an inflammatory process of the pancreas, which is replaced by fibrosis and progressive destruction. The three major clinical features of chronic pancreatitis are pain, maldigestion, and diabetes. Chronic pancreatitis has a profound impact on social life and employment patterns. In the current issue, different topics highlight experimental models of chronic pancreatitis and bridge findings from recent research to bedside. Although the disease is still difficult to treat the current papers represent useful guidelines on how to approach chronic pancreatitis in the clinical settings with the major aim to improve the patient's suffering and quality of life.

Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions

PubMed Central

P, Saha; J, Humphries; B, Modarai; K, Mattock; M, Waltham; C, Evans; A, Ahmad; A, Patel; S, Premaratne; OTA, Lyons; A, Smith

2011-01-01

Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution. PMID:21325673

Current Barriers to Large-scale Interoperability of Traceability Technology in the Seafood Sector.

PubMed

Hardt, Marah J; Flett, Keith; Howell, Colleen J

2017-08-01

Interoperability is a critical component of full-chain digital traceability, but is almost nonexistent in the seafood industry. Using both quantitative and qualitative methodology, this study explores the barriers impeding progress toward large-scale interoperability among digital traceability systems in the seafood sector from the perspectives of seafood companies, technology vendors, and supply chains as a whole. We highlight lessons from recent research and field work focused on implementing traceability across full supply chains and make some recommendations for next steps in terms of overcoming challenges and scaling current efforts. © 2017 Institute of Food Technologists®.

Semantic e-Science in Space Physics - A Case Study

NASA Astrophysics Data System (ADS)

Narock, T.; Yoon, V.; Merka, J.; Szabo, A.

2009-05-01

Several search and retrieval systems for space physics data are currently under development in NASA's heliophysics data environment. We present a case study of two such systems, and describe our efforts in implementing an ontology to aid in data discovery. In doing so we highlight the various aspects of knowledge representation and show how they led to our ontology design, creation, and implementation. We discuss advantages that scientific reasoning allows, as well as difficulties encountered in current tools and standards. Finally, we present a space physics research project conducted with and without e-Science and contrast the two approaches.

New targets in the search for preventive and therapeutic agents for botulism.

PubMed

Anniballi, Fabrizio; Lonati, Davide; Fiore, Alfonsina; Auricchio, Bruna; De Medici, Dario; Locatelli, Carlo Alessandro

2014-09-01

Botulism is a severe neuroparalytic disease resulting from exposure to one of the most poisonous toxins to humans. Because of this high potency and the use of toxins as biological weapons, botulism is a public health concern and each case represents an emergency. Current therapy involves respiratory supportive care and anti-toxins administration. As a preventive measure, vaccination against toxins represents an effective strategy but is undesirable due the rarity of botulism and the effectiveness of toxins in treating several neuromuscular disorders. This paper summarizes the current issues in botulism treatment and prevention, highlighting the challenge for future researches.

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress.

PubMed

Zhang, Xiao-Liang; Pang, Wei; Hu, Xin-Tian; Li, Jia-Li; Yao, Yong-Gang; Zheng, Yong-Tang

2014-11-18

Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China.

2016 NIH Research Highlights | NIH MedlinePlus the Magazine

MedlinePlus

... Research Highlights Follow us Breaking New Ground: NIH Research Highlights With NIH support, scientists across the U.S. ... confirming the long-term benefits of the therapy. Research to treat obesity in new ways Adults have ...

Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition.

PubMed

Osland, Emma J; Ali, Azmat; Isenring, Elizabeth; Ball, Patrick; Davis, Melvyn; Gillanders, Lyn

2014-01-01

This work represents the first part of a progressive review of AuSPEN's 1999 Guidelines for Provision of Micronutrient Supplementation in Adult Patients receiving Parenteral Nutrition, in recognition of the developments in the literature on this topic since that time. A systematic literature review was undertaken and recommendations were made based on the available evidence and with consideration to specific elements of the Australian and New Zealand practice environment. The strength of evidence underpinning each recommendation was assessed. External reviewers provided feedback on the guidelines using the AGREE II tool. Reduced doses of manganese, copper, chromium and molybdenum, and an increased dose of selenium are recommended when compared with the 1999 guidelines. Currently the composition of available multi-trace element formulations is recognised as an obstacle to aligning these guidelines with practice. A paucity of available literature and limitations with currently available methods of monitoring trace element status are acknowledged. The currently unknown clinical impact of changes to trace element contamination of parenteral solutions with contemporary practices highlights need for research and clinical vigilance in this area of nutrition support practice. Trace elements are essential and should be provided daily to patients receiving parenteral nutrition. Monitoring is generally only required in longer term parenteral nutrition, however should be determined on an individual basis. Industry is encouraged to modify existing multi-trace element solutions available in Australia and New Zealand to reflect changes in the literature outlined in these guidelines. Areas requiring research are highlighted.

Flaws in current human training protocols for spontaneous Brain-Computer Interfaces: lessons learned from instructional design

PubMed Central

Lotte, Fabien; Larrue, Florian; Mühl, Christian

2013-01-01

While recent research on Brain-Computer Interfaces (BCI) has highlighted their potential for many applications, they remain barely used outside laboratories. The main reason is their lack of robustness. Indeed, with current BCI, mental state recognition is usually slow and often incorrect. Spontaneous BCI (i.e., mental imagery-based BCI) often rely on mutual learning efforts by the user and the machine, with BCI users learning to produce stable ElectroEncephaloGraphy (EEG) patterns (spontaneous BCI control being widely acknowledged as a skill) while the computer learns to automatically recognize these EEG patterns, using signal processing. Most research so far was focused on signal processing, mostly neglecting the human in the loop. However, how well the user masters the BCI skill is also a key element explaining BCI robustness. Indeed, if the user is not able to produce stable and distinct EEG patterns, then no signal processing algorithm would be able to recognize them. Unfortunately, despite the importance of BCI training protocols, they have been scarcely studied so far, and used mostly unchanged for years. In this paper, we advocate that current human training approaches for spontaneous BCI are most likely inappropriate. We notably study instructional design literature in order to identify the key requirements and guidelines for a successful training procedure that promotes a good and efficient skill learning. This literature study highlights that current spontaneous BCI user training procedures satisfy very few of these requirements and hence are likely to be suboptimal. We therefore identify the flaws in BCI training protocols according to instructional design principles, at several levels: in the instructions provided to the user, in the tasks he/she has to perform, and in the feedback provided. For each level, we propose new research directions that are theoretically expected to address some of these flaws and to help users learn the BCI skill more efficiently. PMID:24062669

Investigating Misophonia: A Review of the Empirical Literature, Clinical Implications, and a Research Agenda

PubMed Central

Brout, Jennifer J.; Edelstein, Miren; Erfanian, Mercede; Mannino, Michael; Miller, Lucy J.; Rouw, Romke; Kumar, Sukhbinder; Rosenthal, M. Zachary

2018-01-01

Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic. We extend previous reviews on this topic by critically reviewing the research investigating mechanisms of misophonia and differences between misophonia and other conditions. In addition, we integrate this small but growing literature with basic and applied research from other literatures in a cross-disciplinary manner. PMID:29467604

Investigating Misophonia: A Review of the Empirical Literature, Clinical Implications, and a Research Agenda.

PubMed

Brout, Jennifer J; Edelstein, Miren; Erfanian, Mercede; Mannino, Michael; Miller, Lucy J; Rouw, Romke; Kumar, Sukhbinder; Rosenthal, M Zachary

2018-01-01

Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic. We extend previous reviews on this topic by critically reviewing the research investigating mechanisms of misophonia and differences between misophonia and other conditions. In addition, we integrate this small but growing literature with basic and applied research from other literatures in a cross-disciplinary manner.

Future fundamental combustion research for aeropropulsion systems

NASA Technical Reports Server (NTRS)

Mularz, E. J.

1985-01-01

Physical fluid mechanics, heat transfer, and chemical kinetic processes which occur in the combustion chamber of aeropropulsion systems were investigated. With the component requirements becoming more severe for future engines, the current design methodology needs the new tools to obtain the optimum configuration in a reasonable design and development cycle. Research efforts in the last few years were encouraging but to achieve these benefits research is required into the fundamental aerothermodynamic processes of combustion. It is recommended that research continues in the areas of flame stabilization, combustor aerodynamics, heat transfer, multiphase flow and atomization, turbulent reacting flows, and chemical kinetics. Associated with each of these engineering sciences is the need for research into computational methods to accurately describe and predict these complex physical processes. Research needs in each of these areas are highlighted.

Children's comprehension of an unfamiliar speaker accent: a review.

PubMed

Harte, Jennifer; Oliveira, Ana; Frizelle, Pauline; Gibbon, Fiona

2016-05-01

The effect of speaker accent on listeners' comprehension has become a key focus of research given the increasing cultural diversity of society and the increased likelihood of an individual encountering a clinician with an unfamiliar accent. To review the studies exploring the effect of an unfamiliar accent on language comprehension in typically developing (TD) children and in children with speech and language difficulties. This review provides a methodological analysis of the relevant studies by exploring the challenges facing this field of research and highlighting the current gaps in the literature. A total of nine studies were identified using a systematic search and organized under studies investigating the effect of speaker accent on language comprehension in (1) TD children and (2) children with speech and/or language difficulties. This review synthesizes the evidence that an unfamiliar speaker accent may lead to a breakdown in language comprehension in TD children and in children with speech difficulties. Moreover, it exposes the inconsistencies found in this field of research and highlights the lack of studies investigating the effect of speaker accent in children with language deficits. Overall, research points towards a developmental trend in children's ability to comprehend accent-related variations in speech. Vocabulary size, language exposure, exposure to different accents and adequate processing resources (e.g. attention) seem to play a key role in children's ability to understand unfamiliar accents. This review uncovered some inconsistencies in the literature that highlight the methodological issues that must be considered when conducting research in this field. It explores how such issues may be controlled in order to increase the validity and reliability of future research. Key clinical implications are also discussed. © 2016 Royal College of Speech and Language Therapists.

In Their Own Words: Research Misconduct from the Perspective of Researchers in Malaysian Universities.

PubMed

Olesen, Angelina P; Amin, Latifah; Mahadi, Zurina

2017-12-16

Published data and studies on research misconduct, which focuses on researchers in Malaysia, is still lacking, therefore, we decided that this was an area for investigation. This study provides qualitative results for the examined issues through series of in-depth interviews with 21 researchers and lecturers in various universities in Malaysia. The aims of this study were to investigate the researchers' opinions and perceptions regarding what they considered to be research misconduct, their experience with such misconduct, and the factors that contribute to research misconduct. Our findings suggest that the most common research misconducts that are currently being witnessed in Malaysian universities are plagiarism and authorship disputes, however, researchers seldom report incidents of research misconduct because it takes too much time, effort and work to report them, and some are just afraid of repercussions when they do report it. This suggests possible loopholes in the monitoring system, which may allow some researchers to bypass it and engage in misconduct. This study also highlights the structural and individual factors as the most influential factors when it comes to research misconduct besides organizational, situational and cultural factors. Finally, this study highlights the concerns of all participants regarding the 'publish or perish' pressure that they believe would lead to a hostile working environment, thus enhancing research misconduct, as researchers tend to think about their own performance rather than that of whole team or faculty. Consequently this weakens the interpersonal relationships among researchers, which may compromise the teaching and supervision of junior researchers and research students.

Ceria-thoria pellet manufacturing in preparation for plutonia-thoria LWR fuel production

NASA Astrophysics Data System (ADS)

Drera, Saleem S.; Björk, Klara Insulander; Sobieska, Matylda

2016-10-01

Thorium dioxide (thoria) has potential to assist in niche roles as fuel for light water reactors (LWRs). One such application for thoria is its use as the fertile component to burn plutonium in a mixed oxide fuel (MOX). Thor Energy and an international consortium are currently irradiating plutonia-thoria (Th-MOX) fuel in an effort to produce data for its licensing basis. During fuel-manufacturing research and development (R&D), surrogate materials were utilized to highlight procedures and build experience. Cerium dioxide (ceria) provides a good surrogate platform to replicate the chemical nature of plutonium dioxide. The project's fuel manufacturing R&D focused on powder metallurgical techniques to ensure manufacturability with the current commercial MOX fuel production infrastructure. The following paper highlights basics of the ceria-thoria fuel production including powder milling, pellet pressing and pellet sintering. Green pellets and sintered pellets were manufactured with average densities of 67.0% and 95.5% that of theoretical density respectively.

Research Ethics 2.0: New Perspectives on Norms, Values, and Integrity in Genomic Research in Times of Even Scarcer Resources

PubMed Central

Brall, Caroline; Maeckelberghe, Els; Porz, Rouven; Makhoul, Jihad; Schröder-Bäck, Peter

2017-01-01

Research ethics anew gained importance due to the changing scientific landscape and increasing demands and competition in the academic field. These changes are further exaggerated because of scarce(r) resources in some countries on the one hand and advances in genomics on the other. In this paper, we will highlight the current challenges thereof to scientific integrity. To mark key developments in research ethics, we will distinguish between what we call research ethics 1.0 and research ethics 2.0. Whereas research ethics 1.0 focuses on individual integrity and informed consent, research ethics 2.0 entails social scientific integrity within a broader perspective of a research network. This research network can be regarded as a network of responsibilities in which every stakeholder involved has to jointly meet the ethical challenges posed to research. PMID:28288472

Research Ethics 2.0: New Perspectives on Norms, Values, and Integrity in Genomic Research in Times of Even Scarcer Resources.

PubMed

Brall, Caroline; Maeckelberghe, Els; Porz, Rouven; Makhoul, Jihad; Schröder-Bäck, Peter

2017-01-01

Research ethics anew gained importance due to the changing scientific landscape and increasing demands and competition in the academic field. These changes are further exaggerated because of scarce(r) resources in some countries on the one hand and advances in genomics on the other. In this paper, we will highlight the current challenges thereof to scientific integrity. To mark key developments in research ethics, we will distinguish between what we call research ethics 1.0 and research ethics 2.0. Whereas research ethics 1.0 focuses on individual integrity and informed consent, research ethics 2.0 entails social scientific integrity within a broader perspective of a research network. This research network can be regarded as a network of responsibilities in which every stakeholder involved has to jointly meet the ethical challenges posed to research. © 2017 S. Karger AG, Basel.

INSPACE CHEMICAL PROPULSION SYSTEMS AT NASA's MARSHALL SPACE FLIGHT CENTER: HERITAGE AND CAPABILITIES

NASA Technical Reports Server (NTRS)

McRight, P. S.; Sheehy, J. A.; Blevins, J. A.

2005-01-01

NASA s Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V rocket and the Space Shuttle external tank, solid rocket boosters, and main engines. This paper highlights a lesser known but very rich side of MSFC-its heritage in the development of in-space chemical propulsion systems and its current capabilities for spacecraft propulsion system development and chemical propulsion research. The historical narrative describes the flight development activities associated with upper stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology (DART), X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and multiple technology development activities. This paper also highlights MSFC s advanced chemical propulsion research capabilities, including an overview of the center s Propulsion Systems Department and ongoing activities. The authors highlight near-term and long-term technology challenges to which MSFC research and system development competencies are relevant. This paper concludes by assessing the value of the full range of aforementioned activities, strengths, and capabilities in light of NASA s exploration missions.

The engagement of children with disabilities in health-related technology design processes: identifying methodology.

PubMed

Allsop, Matthew J; Holt, Raymond J; Levesley, Martin C; Bhakta, Bipinchandra

2010-01-01

This review aims to identify research methodology that is suitable for involving children with disabilities in the design of healthcare technology, such as assistive technology and rehabilitation equipment. A review of the literature included the identification of methodology that is available from domains outside of healthcare and suggested a selection of available methods. The need to involve end users within the design of healthcare technology was highlighted, with particular attention to the need for greater levels of participation from children with disabilities within all healthcare research. Issues that may arise when trying to increase such involvement included the need to consider communication via feedback and tailored information, the need to measure levels of participation occurring in current research, and caution regarding the use of proxy information. Additionally, five suitable methods were highlighted that are available for use with children with disabilities in the design of healthcare technology. The methods identified in the review need to be put into practice to establish effective and, if necessary, novel ways of designing healthcare technology when end users are children with disabilities.

JSC Advanced Curation: Research and Development for Current Collections and Future Sample Return Mission Demands

NASA Technical Reports Server (NTRS)

Fries, M. D.; Allen, C. C.; Calaway, M. J.; Evans, C. A.; Stansbery, E. K.

2015-01-01

Curation of NASA's astromaterials sample collections is a demanding and evolving activity that supports valuable science from NASA missions for generations, long after the samples are returned to Earth. For example, NASA continues to loan hundreds of Apollo program samples to investigators every year and those samples are often analyzed using instruments that did not exist at the time of the Apollo missions themselves. The samples are curated in a manner that minimizes overall contamination, enabling clean, new high-sensitivity measurements and new science results over 40 years after their return to Earth. As our exploration of the Solar System progresses, upcoming and future NASA sample return missions will return new samples with stringent contamination control, sample environmental control, and Planetary Protection requirements. Therefore, an essential element of a healthy astromaterials curation program is a research and development (R&D) effort that characterizes and employs new technologies to maintain current collections and enable new missions - an Advanced Curation effort. JSC's Astromaterials Acquisition & Curation Office is continually performing Advanced Curation research, identifying and defining knowledge gaps about research, development, and validation/verification topics that are critical to support current and future NASA astromaterials sample collections. The following are highlighted knowledge gaps and research opportunities.

A Longitudinal Study of Illinois High School Graduates with Disabilities: A Six-Year Analysis of Postsecondary Enrollment and Completion. Policy Research: IERC 2010-4

ERIC Educational Resources Information Center

Lichtenberger, Eric J.

2010-01-01

This study highlights the postsecondary pathways of students with disabilities from the Illinois high school class of 2002 (N=7,598) and provides comparisons to the students from the same cohort without a disability (N=105,537). The current study has two parts: 1) an analysis of the differences between students with disabilities and students…

Hubble trial: time to stick to basics for treatment of haemorrhoids?

PubMed

Brown, S R

2017-01-01

The results of the Hubble trial, a randomised controlled trial comparing haemorrhoidal artery ligation with rubber band ligation for early-grade prolapsing haemorrhoids, are discussed. The difficulties in defining treatment success are debated along with the trial design highlighting the pitfalls of previous research. A finding that haemorrhoidal artery ligation is not necessarily superior to cheap alternatives has implications for current practice and future commissioning of surgeons.

Families of Children with Down Syndrome: What We Know and What We Need to Know

ERIC Educational Resources Information Center

Cuskelly, Monica; Hauser-Cram, Penny; Van Riper, Marcia

2009-01-01

This paper provides a brief overview of what is currently known about families of children with Down syndrome. In addition, it highlights a number of issues that require further research if we are to have a thorough understanding of the impact of a child with Down syndrome on families as a system and on the individuals who make up that system.…

Overview of NASA MSFC and UAH Space Weather Modeling and Data Efforts

NASA Technical Reports Server (NTRS)

Parker, Linda Neergaard

2016-01-01

Marshall Space Flight Center, along with its industry and academia neighbors, has a long history of space environment model development and testing. Space weather efforts include research, testing, model development, environment definition, anomaly investigation, and operational support. This presentation will highlight a few of the current space weather activities being performed at Marshall and through collaborative efforts with University of Alabama in Huntsville scientists.

Lack of symmetry in employees' perceptions of the psychological contract.

PubMed

Jepsen, Denise M; Rodwell, John J

2012-06-01

Despite debate on the nature of employees' perceptions of their psychological contract, little research has compared employees' and employers' sides of the psychological contract. All 80 items from both scales in the Psychological Contract Inventory were used in a survey of 436 currently working, non-student respondents. Structural equation modeling yielded nonsymmetrical perspectives on promises and obligations, highlighting the validity of approaching the issues via individual perceptions.

Relating therapy for people who hear voices: perspectives from clients, family members, referrers and therapists.

PubMed

Hayward, Mark; Fuller, Ella

2010-01-01

Current psychological models of voice hearing emphasise the personal meaning that individuals attribute to the voice hearing experience. Recent developments in theory and research have highlighted the importance of the relationship between the hearer and the voice. This study aims to contribute to this area of research, by exploring the experience and usefulness of a new form of 'Relating Therapy' that aims to modify distressing relationships with voices. Semi-structured interviews were conducted with ten participants and explored the experience and usefulness of a pilot of Relating Therapy: three therapists, three voice hearers, two relatives and two referrers. Interviews were transcribed and analysed using Interpretative Phenomenological Analysis. Three themes that emerged from the analysis are presented for discussion: engaging with the therapeutic model; developing a new relating style; and how change is described and defined by participants. This study is consistent with the growing body of theory and research that highlights the interpersonal nature of the voice hearing experience. It also offers tentative support for a therapeutic framework that aims to modify distressing relationships with voices as a means of bringing about positive change. Clinical implications and areas for future research are outlined.  © 2009 John Wiley & Sons, Ltd.

Self-esteem and evaluative beliefs in paranoia.

PubMed

Valiente, Carmen; Cantero, Dolores; Sánchez, Alvaro; Provencio, María; Wickham, Sophie

2014-06-01

Psychological models have implicated negative self-esteem as an important factor underlying paranoia. However, research investigating the role of self-esteem in paranoia suffers from poor conceptual and methodological understanding, resulting in conflicting findings. Central to this problem is the use of measures investigating global self-esteem and self-evaluative beliefs interchangeably. In the present study we aimed to analyze differences in self-esteem domains and self-evaluation. The present study used interviews and questionnaires to compare a clinical sample of participants who were currently paranoid (n = 55) with healthy controls (n = 57) on global self-esteem domains and negative evaluative beliefs, in order to investigate the multi-faceted role of "the self". There was no significant difference in self-esteem domains between groups, highlighting that self-esteem is preserved in currently paranoid individuals. However, the paranoid group had significantly more negative evaluative beliefs. Interestingly, our global measures of self-esteem and measures of negative evaluative beliefs were uncorrelated, highlighting the importance of understanding the differences underlying these concepts. This study does not address dynamic aspects of self-esteem and self-evaluation. The present study provides undeniable evidence to investigate self-concept dimensions separately. These findings must be considered by researchers interested in the role of the self in the onset and maintenance of paranoia. Copyright © 2014 Elsevier Ltd. All rights reserved.

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications.

PubMed

Nikitakis, Nikolaos G; Pentenero, Monica; Georgaki, Maria; Poh, Catherine F; Peterson, Douglas E; Edwards, Paul; Lingen, Mark; Sauk, John J

2018-06-01

Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered. Copyright © 2018 Elsevier Inc. All rights reserved.

An evaluation of the role and effectiveness of institutional biosafety committees in providing oversight and security at biocontainment laboratories.

PubMed

Race, Margaret S; Hammond, Edward

2008-03-01

Institutional biosafety committees (IBCs) have been charged with the oversight and review of biosafety at thousands of biocontainment labs nationwide, hundreds of which are high-level BSL-3 and BSL-4 labs. In light of the recent rapid proliferation of BSL-3 and BSL-4 facilities and the increases in research in the areas of biodefense, select agents, recombinant DNA, and synthetic biology and dual-use research, questions have been raised about whether IBCs are fulfilling their oversight responsibilities. This article reviews information on the responsibilities and expectations of IBCs as currently constituted and provides an analysis of IBC performance from survey data of hundreds of research institutions over the past several years. The findings highlight serious ongoing problems with IBCs' adherence to NIH Guidelines. This raises questions about the current voluntary governance framework as an effective system to monitor and oversee U.S. research facilities, including high-containment facilities, and their research activities. The findings strongly suggest the need for immediate improvement or replacement of the IBC system.

Burning Down the Silos: Integrating new perspectives from the social sciences into human behavior in fire research.

PubMed

Kuligowski, Erica

2017-01-01

The traditional social science disciplines can provide many benefits to the field of human behavior in fire (HBiF). First, the social sciences delve further into insights only marginally examined by HBiF researchers, in turn, expanding the depth of HBiF research. In this paper, I present examples of studies from the fields of social psychology and sociology that would expand HBiF research into non-engineering or "unobservable" aspects of behavior during a fire event. Second, the social sciences can provide insight into new areas of research; in turn, expanding the scope of HBiF research. In this section, I introduce pre- and post-fire studies and explore potential research questions that fall outside of the response period of a fire, the phase upon which most focus is currently placed. Third, the social sciences elucidate the value of research methods available to study human behavior. Qualitative research methods are specifically highlighted. These three benefits will allow HBiF researchers to collect a wider range of data, further develop and expand current behavioral knowledge, and increase the impact of this research for both social and engineering applications. Finally, I end with a discussion on possible ways to better integrate the social sciences within human behavior in fire.

Implementing enhanced recovery pathways: a literature review with realist synthesis.

PubMed

Coxon, Astrid; Nielsen, Karina; Cross, Jane; Fox, Chris

2017-10-01

Enhanced Recovery Pathways (ERPs) are an increasingly popular, evidenced-based approach to surgery, designed to improve patient outcomes and reduce costs. Despite evidence demonstrating the benefits of these pathways, implementation and adherence have been inconsistent. Using realist synthesis, this review explored the current literature surrounding the implementation of ERPs in the UK. Knowledge consolidation between authors and consulting with field experts helped to guide the search strategy. Relevant medical and social science databases were searched from 2000 to 2016, as well as a general web search. A total of 17 papers were identified, including original research, reviews, case studies and guideline documents. Full texts were analysed, cross-examined, and data extracted and synthesised. Several implementation strategies were identified, including the contexts in which these operated, the subsequent mechanisms of action that were triggered, and the outcome patterns they produced. Context-Mechanism-Outcome (CMO) configurations were generated, tested, and refined. These were grouped to develop two programme theories concerning ERP implementation, one related to the strategy of consulting with staff, the other with appointing a change agent to coordinate and drive the implementation process. These theories highlight instances in which implementation could be improved. Current literature in ERP research is primarily focussed on measuring patient outcomes and cost effectiveness, and as a result, important detail regarding the implementation process is often not reported or described robustly. This review not only provides recommendations for future improvements in ERP implementation, but also highlights specific areas of focus for furthering ERP implementation research.

Mental health and disorders. Editorial.

PubMed

Wittchen, Hans-Ulrich

2014-01-01

Mental health and mental disorders pose a tremendous challenge to the societal, health, and research policies in Europe, and sound advice is needed on a potential strategy for mental health research investment. Toward this goal, the ROAMER initiative ("Roadmap for Mental Health Research in Europe") was launched to map the current state of the art, to identify gaps and to delineate advances needed in various areas and domains of mental health research in Europe. To further stimulate discussions among the scientific community and stakeholders on how to improve mental health research and to promote an improved research agenda for the next decade, this IJMPR topic issue presents the overall ROAMER methodology as well as a series of selected papers highlighting critical issues of psychological approaches and interventions as outcomes of the ROAMER work package 5 "Psychological research and treatments". Copyright © 2013 John Wiley & Sons, Ltd.

Interactions of dendrimers with biological drug targets: reality or mystery - a gap in drug delivery and development research.

PubMed

Ahmed, Shaimaa; Vepuri, Suresh B; Kalhapure, Rahul S; Govender, Thirumala

2016-07-21

Dendrimers have emerged as novel and efficient materials that can be used as therapeutic agents/drugs or as drug delivery carriers to enhance therapeutic outcomes. Molecular dendrimer interactions are central to their applications and realising their potential. The molecular interactions of dendrimers with drugs or other materials in drug delivery systems or drug conjugates have been extensively reported in the literature. However, despite the growing application of dendrimers as biologically active materials, research focusing on the mechanistic analysis of dendrimer interactions with therapeutic biological targets is currently lacking in the literature. This comprehensive review on dendrimers over the last 15 years therefore attempts to identify the reasons behind the apparent lack of dendrimer-receptor research and proposes approaches to address this issue. The structure, hierarchy and applications of dendrimers are briefly highlighted, followed by a review of their various applications, specifically as biologically active materials, with a focus on their interactions at the target site. It concludes with a technical guide to assist researchers on how to employ various molecular modelling and computational approaches for research on dendrimer interactions with biological targets at a molecular level. This review highlights the impact of a mechanistic analysis of dendrimer interactions on a molecular level, serves to guide and optimise their discovery as medicinal agents, and hopes to stimulate multidisciplinary research between scientific, experimental and molecular modelling research teams.

Reframing convenience food.

PubMed

Jackson, Peter; Viehoff, Valerie

2016-03-01

This paper provides a critical review of recent research on the consumption of 'convenience' food, highlighting the contested nature of the term and exploring its implications for public health and environmental sustainability. It distinguishes between convenience food in general and particular types of convenience food, such as ready-meals, tracing the structure and growth of the market for such foods with a particular emphasis on the UK which currently has the highest rate of ready-meal consumption in Europe. Having established the definitional complexities of the term, the paper presents the evidence from a systematic review of the literature, highlighting the significance of convenience food in time-saving and time-shifting, the importance of recent changes in domestic labour and family life, and the way the consumption of convenience food is frequently moralized. The paper shows how current debates about convenience food are part of a longer discursive history about food, health and nutrition. It discusses current levels of public understanding about the links between convenience food, environmental sustainability and food waste. The paper concludes by making a case for understanding the consumption of convenience food in terms of everyday social practices, emphasising its habitual and routine character. Copyright © 2015 Elsevier Ltd. All rights reserved.

Explanations of firesetting in mentally disordered offenders: a review of the literature.

PubMed

Tyler, Nichola; Gannon, Theresa A

2012-01-01

This paper reviews current explanations of firesetting in adult mentally disordered offenders. In particular, attention is given to contemporary research that has examined developmental and background characteristics, personality and associated traits, motivation for firesetting, neurobiological explanations, psychiatric diagnoses, and frequency of self-injurious behavior, including suicide. The likelihood of recidivism and associated risk factors is also considered. Evaluation of the existing research has highlighted that even though a significant proportion has been conducted with psychiatric populations, little is understood about firesetting by mentally disordered offenders. In addition, little research has been conducted that compares mentally disordered firesetters to both other mentally disordered offenders and non-mentally disordered offenders. Recommendations are made for future research to further develop knowledge of this behavior.

Designing and measuring the progress and impact of health research capacity strengthening initiatives

PubMed Central

2015-01-01

Strengthening capacity in poorer countries to generate multi-disciplinary health research and to utilise research findings, is one of the most effective ways of advancing the countries' health and development. This paper explores current knowledge about how to design health research capacity strengthening (RCS) programmes and how to measure their progress and impact. It describes a systematic, evidence-based approach for designing such programmes and highlights some of the key challenges that will be faced in the next 10 years. These include designing and implementing common frameworks to facilitate comparisons among capacity strengthening projects, and developing monitoring indicators that can capture their interactions with knowledge users and their impact on changes in health systems. PMID:28281707

Significance of Pharmacogenetics and Pharmacogenomics Research in Current Medical Practice.

PubMed

Prakash, Swayam; Agrawal, Suraksha

2016-01-01

Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have shown that how variation in the genome at single nucleotide level can be used in pharmacological research. The two broad aspects that deal with pharmacological research are pharmacogenetics and pharmacogenomics. This review encompasses how these variations have created the basis of pharmacogenetics and pharmacogenomics research and important milestones accomplished in these two fields in different diseases. It further discusses at length their importance in disease diagnosis, response of drugs, and various treatment modalities on the basis of genetic determinants.

Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010.

PubMed

Steckelings, U Muscha; De Mey, Jo G R; Pinto-Sietsma, Sara-Joan; Henrion, Daniel; Unger, Thomas

2011-01-01

The 15th Annual Meeting of the European Council of Cardiovascular Research brought together basic and clinical scientists working in the cardiovascular field in La Colle sur Loup, France. Upfront basic and clinical research addressing the mechanisms of disease, identification of biomarkers or development of new treatments was communicated in 101 presentations, 35 of them as a part of five on-topic oral sessions and three workshops. Three keynote lectures reviewed current knowledge and the latest data about mechanosensitive channels in pressure regulation, cell therapy in cardiovascular disease and mechanisms of cardiovascular risk associated with diabetic nephropathy. This article summarizes highlights of the oral sessions, workshops and keynote lectures.

Priorities for Cardiovascular Outcomes Research: A Report of the National Heart, Lung, and Blood Institute's Centers for Cardiovascular Outcomes Research Working Group.

PubMed

Khazanie, Prateeti; Krumholz, Harlan M; Kiefe, Catarina I; Kressin, Nancy R; Wells, Barbara; Wang, Tracy Y; Peterson, Eric D

2017-07-01

The Centers for Cardiovascular Outcomes Research (CCORs) held a meeting to review how cardiovascular outcomes research had evolved in the decade since the National Heart, Lung, and Blood Institute 2004 working group report and to consider future directions. The conference involved representatives from governmental agencies, outcomes research thought leaders, and public and private healthcare partners. The main purposes of this meeting were to (1) advance collaborative high-yield, high-impact outcomes research; (2) identify priorities and barriers to important cardiovascular outcomes research; and (3) define future needs for the field. This report highlights the key topics covered during the meeting, including an examination of the recent history of outcomes research, an evaluation of the current academic climate, and a vision for the future of cardiovascular outcomes research. © 2017 American Heart Association, Inc.

Recent progress in biomass burning research: a perspective from analyses of satellite data and model studies. (Invited)

NASA Astrophysics Data System (ADS)

Logan, J. A.

2010-12-01

Significant progress has been made in using satellite data to provide bottom-up constraints on biomass burning (BB) emissions. However, inverse studies with CO satellite data imply that tropical emissions are underestimated by current inventories, while model simulations of the ARCTAS period imply that the FLAMBE estimates of extratropical emissions are significantly overestimated. Injection heights of emissions from BB have been quantified recently using MISR data, and these data provide some constraints on 1-d plume models. I will discuss recent results in these areas, highlighting future research needs.

Gambling disorder in adolescents: prevalence, new developments, and treatment challenges

PubMed Central

Floros, Georgios D

2018-01-01

Research on adolescence gambling over the past twenty years has revealed significant incidence and prevalence rates and highlighted the possible negative effects on an adolescent’s well-being. Several risk and protective factors have also been identified. Over the course of the past few years, technological advances have heralded the advent of new avenues for gambling as well as new opportunities to gamble without any direct monetary exchange. This review article examines those established trends as well as the new issues that we are faced with, in order to accurately portray the current challenges in research, prevention, and treatment. PMID:29535564

SAGA: A project to automate the management of software production systems

NASA Technical Reports Server (NTRS)

Campbell, R. H.

1983-01-01

The current work in progress for the SAGA project are described. The highlights of this research are: a parser independent SAGA editor, design for the screen editing facilities of the editor, delivery to NASA of release 1 of Olorin, the SAGA parser generator, personal workstation environment research, release 1 of the SAGA symbol table manager, delta generation in SAGA, requirements for a proof management system, documentation for and testing of the cyber pascal make prototype, a prototype cyber-based slicing facility, a June 1984 demonstration plan, SAGA utility programs, summary of UNIX software engineering support, and theorem prover review.

Respiratory Allergies: A General Overview of Remedies, Delivery Systems, and the Need to Progress

PubMed Central

Colombo, Giselda; Celenza, Cinzia

2014-01-01

The spread of respiratory allergies is increasing in parallel with the alarm of the scientific community. Evidently, our knowledge of the onset mechanisms of these diseases and, as a consequence, of the available remedies is inadequate. This review provides a brief, general description of current therapeutic resources and the state of research with regard to both drugs and medical devices in order to highlight their limits and the urgent need for progress. Increasing the amount of basic biochemical research will improve our knowledge of such onset mechanisms and the potential efficacy of therapeutic preparations. PMID:25006500

Gambling disorder in adolescents: prevalence, new developments, and treatment challenges.

PubMed

Floros, Georgios D

2018-01-01

Research on adolescence gambling over the past twenty years has revealed significant incidence and prevalence rates and highlighted the possible negative effects on an adolescent's well-being. Several risk and protective factors have also been identified. Over the course of the past few years, technological advances have heralded the advent of new avenues for gambling as well as new opportunities to gamble without any direct monetary exchange. This review article examines those established trends as well as the new issues that we are faced with, in order to accurately portray the current challenges in research, prevention, and treatment.

Evidence base and future research directions in the management of low back pain.

PubMed

Abbott, Allan

2016-03-18

Low back pain (LBP) is a prevalent and costly condition. Awareness of valid and reliable patient history taking, physical examination and clinical testing is important for diagnostic accuracy. Stratified care which targets treatment to patient subgroups based on key characteristics is reliant upon accurate diagnostics. Models of stratified care that can potentially improve treatment effects include prognostic risk profiling for persistent LBP, likely response to specific treatment based on clinical prediction models or suspected underlying causal mechanisms. The focus of this editorial is to highlight current research status and future directions for LBP diagnostics and stratified care.

Applying the design-build-test paradigm in microbiome engineering.

PubMed

Pham, Hoang Long; Ho, Chun Loong; Wong, Adison; Lee, Yung Seng; Chang, Matthew Wook

2017-12-01

The recently discovered roles of human microbiome in health and diseases have inspired research efforts across many disciplines to engineer microbiome for health benefits. In this review, we highlight recent progress in human microbiome research and how modifications to the microbiome could result in implications to human health. Furthermore, we discuss the application of a 'design-build-test' framework to expedite microbiome engineering efforts by reviewing current literature on three key aspects: design principles to engineer the human microbiome, methods to engineer microbiome with desired functions, and analytical techniques to examine complex microbiome samples. Copyright © 2017 Elsevier Ltd. All rights reserved.

Priorities and needs for research on urban interventions targeting vector-borne diseases: rapid review of scoping and systematic reviews.

PubMed

Bermudez-Tamayo, Clara; Mukamana, Olive; Carabali, Mabel; Osorio, Lyda; Fournet, Florence; Dabiré, Kounbobr Roch; Turchi Marteli, Celina; Contreras, Adolfo; Ridde, Valéry

2016-12-01

This paper highlights the critical importance of evidence on vector-borne diseases (VBD) prevention and control interventions in urban settings when assessing current and future needs, with a view to setting policy priorities that promote inclusive and equitable urban health services. Research should produce knowledge about policies and interventions that are intended to control and prevent VBDs at the population level and to reduce inequities. Such interventions include policy, program, and resource distribution approaches that address the social determinants of health and exert influence at organizational and system levels.

DNA origami nanopores: developments, challenges and perspectives

NASA Astrophysics Data System (ADS)

Hernández-Ainsa, Silvia; Keyser, Ulrich F.

2014-11-01

DNA nanotechnology has enabled the construction of DNA origami nanopores; synthetic nanopores that present improved capabilities for the area of single molecule detection. Their extraordinary versatility makes them a new and powerful tool in nanobiotechnology for a wide range of important applications beyond molecular sensing. In this review, we briefly present the recent developments in this emerging field of research. We discuss the current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores. Finally, we anticipate novel avenues for future research and highlight a range of exciting ideas and applications that could be explored in the near future.

Navigating translational ecology: Creating opportunities for scientist participation

USGS Publications Warehouse

Hallett, Lauren M.; Morelli, Toni; Gerber, Leah R.; Moritz, Max A.; Schwartz, Mark W.; Stephenson, Nathan L.; Tank, Jennifer L.; Williamson, Matthew A.; Woodhouse, Connie A.

2017-01-01

Interest in translational ecology (TE) – a research approach that yields useful scientific outcomes through ongoing collaboration between scientists and stakeholders – is growing among both of these groups. Translational ecology brings together participants from different cultures and with different professional incentives. We address ways to cultivate a culture of TE, such as investing time in understanding one another's decision context and incentives, and outline common entry points to translational research, such as working through boundary organizations, building place-based research programs, and being open to opportunities as they arise. We also highlight common institutional constraints on scientists and practitioners, and ways in which collaborative research can overcome these limitations, emphasizing considerations for navigating TE within current institutional frameworks, but also pointing out ways in which institutions are evolving to facilitate translational research approaches.

Chromatin: Its history, current research, and the seminal researchers and their philosophy.

PubMed

Deichmann, Ute

2015-01-01

The concept of chromatin as a complex of nucleic acid and proteins in the cell nucleus was developed by cytologists and biochemists in the late 19th century. It was the starting point for biochemical research on DNA and nuclear proteins. Although interest in chromatin declined rapidly at the beginning of the 20th century, a few decades later a new focus on chromatin emerged, which was not only related to its structure, but also to its function in gene regulatory processes in the development of higher organisms. Since the late 20th century, research on chromatin modifications has also been conducted under the label of epigenetics. This article highlights the major phases of chromatin research until the present time and introduces major investigators and their scientific and philosophical outlooks.

Insights from a Recent Meeting: Current Status and Future Directions in Magnesium Corrosion Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, Michael P.; Joost, William J.; David Warren, C.

The United States Department of Energy Vehicle Technologies Office held a Technical Review Meeting entitled “Current Status and Future Directions in Magnesium Corrosion Research” at Oak Ridge National Laboratory in April 2016. Here current funded Mg corrosion projects presented their latest results, along with invited presentations from academic and industrial researchers in the area of Mg corrosion. This paper overviews select topics from the meeting, with an emphasis on relaying meeting discussion points regarding future needs in understanding and mitigating Mg corrosion, particularly for automotive applications. Topics highlighted include the need for pretreatments and coatings suitable for mass vehicle productionmore » of Mg components, particularly for dissimilar metal joints involving Mg, Al, or steel, and corrosion evaluation methods more relevant to automotive components and operating conditions. Finally, from a scientific perspective, the need for better fundamental understanding of Mg dissolution, hydrogen evolution, and film formation behavior was a recurring theme, as was phenomena related to microgalvanic coupling involving second phases and impurities in Mg.« less

Insights from a Recent Meeting: Current Status and Future Directions in Magnesium Corrosion Research

DOE PAGES

Brady, Michael P.; Joost, William J.; David Warren, C.

2016-11-17

The United States Department of Energy Vehicle Technologies Office held a Technical Review Meeting entitled “Current Status and Future Directions in Magnesium Corrosion Research” at Oak Ridge National Laboratory in April 2016. Here current funded Mg corrosion projects presented their latest results, along with invited presentations from academic and industrial researchers in the area of Mg corrosion. This paper overviews select topics from the meeting, with an emphasis on relaying meeting discussion points regarding future needs in understanding and mitigating Mg corrosion, particularly for automotive applications. Topics highlighted include the need for pretreatments and coatings suitable for mass vehicle productionmore » of Mg components, particularly for dissimilar metal joints involving Mg, Al, or steel, and corrosion evaluation methods more relevant to automotive components and operating conditions. Finally, from a scientific perspective, the need for better fundamental understanding of Mg dissolution, hydrogen evolution, and film formation behavior was a recurring theme, as was phenomena related to microgalvanic coupling involving second phases and impurities in Mg.« less

The visibility of scientific misconduct: A review of the literature on retracted journal articles.

PubMed

Hesselmann, Felicitas; Graf, Verena; Schmidt, Marion; Reinhart, Martin

2017-10-01

Retractions of scientific articles are becoming the most relevant institution for making sense of scientific misconduct. An increasing number of retracted articles, mainly attributed to misconduct, is currently providing a new empirical basis for research about scientific misconduct. This article reviews the relevant research literature from an interdisciplinary context. Furthermore, the results from these studies are contextualized sociologically by asking how scientific misconduct is made visible through retractions. This study treats retractions as an emerging institution that renders scientific misconduct visible, thus, following up on the sociology of deviance and its focus on visibility. The article shows that retractions, by highlighting individual cases of misconduct and general policies for preventing misconduct while obscuring the actors and processes through which retractions are effected, produce highly fragmented patterns of visibility. These patterns resemble the bifurcation in current justice systems.

Prospects and challenges for fungal metatranscriptomes of complex communities

DOE PAGES

Kuske, Cheryl Rae; Hesse, Cedar Nelson; Challacombe, Jean Faust; ...

2015-01-22

We report that the ability to extract and purify messenger RNA directly from plants, decomposing organic matter and soil, followed by high-throughput sequencing of the pool of expressed genes, has spawned the emerging research area of metatranscriptomics. Each metatranscriptome provides a snapshot of the composition and relative abundance of actively transcribed genes, and thus provides an assessment of the interactions between soil microorganisms and plants, and collective microbial metabolic processes in many environments. We highlight current approaches for analysis of fungal transcriptome and metatranscriptome datasets across a gradient of community complexity, and note benefits and pitfalls associated with those approaches.more » Finally, we discuss knowledge gaps that limit our current ability to interpret metatranscriptome datasets and suggest future research directions that will require concerted efforts within the scientific community.« less

Toxins produced in cyanobacterial water blooms – toxicity and risks

PubMed Central

Bláha, Luděk; Babica, Pavel; Maršálek, Blahoslav

2009-01-01

Cyanobacterial blooms in freshwaters represent a major ecological and human health problem worldwide. This paper briefly summarizes information on major cyanobacterial toxins (hepatotoxins, neurotoxins etc.) with special attention to microcystins-cyclic heptapeptides with high acute and chronic toxicities. Besides discussion of human health risks, microcystin ecotoxicology and consequent ecological risks are also highlighted. Although significant research attention has been paid to microcystins, cyanobacteria produce a wide range of currently unknown toxins, which will require research attention. Further research should also address possible additive, synergistic or antagonistic effects among different classes of cyanobacterial metabolites, as well as interactions with other toxic stressors such as metals or persistent organic pollutants. PMID:21217843

New working paradigms in research laboratories.

PubMed

Keighley, Wilma; Sewing, Andreas

2009-07-01

Work in research laboratories, especially within centralised functions in larger organisations, is changing fast. With easier access to external providers and Contract Research Organisations, and a focus on budgets and benchmarking, scientific expertise has to be complemented with operational excellence. New concepts, globally shared projects and restricted resources highlight the constraints of traditional operating models working from Monday to Friday and nine to five. Whilst many of our scientists welcome this new challenge, organisations have to enable and foster a more business-like mindset. Organisational structures, remuneration, as well as systems in finance need to be adapted to build operations that are best-in-class rather than merely minimising negative impacts of current organisational structures.

Bronchopulmonary Dysplasia: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

PubMed Central

McEvoy, Cindy T.; Jain, Lucky; Schmidt, Barbara; Abman, Steven; Bancalari, Eduardo

2014-01-01

Bronchopulmonary dysplasia (BPD) is the most common complication of extreme preterm birth. Infants who develop BPD manifest aberrant or arrested pulmonary development and can experience lifelong alterations in cardiopulmonary function. Despite decades of promising research, primary prevention of BPD has proven elusive. This workshop report identifies current barriers to the conduct of primary prevention studies for BPD and causal pathways implicated in BPD pathogenesis. Throughout, we highlight promising areas for research to improve understanding of normal and aberrant lung development, distinguish BPD endotypes, and ascertain biomarkers for more targeted therapeutic approaches to prevention. We conclude with research recommendations and priorities to accelerate discovery and promote lung health in infants born preterm. PMID:24754823

Metals and Ceramics Division annual progress report, October 1, 1978-June 30, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, S.

Research is reported concerning: (1) engineering materials including materials compatibility, mechanical properties, nondestructive testing, pressure vessel technology, and welding and brazing; (2) fuels and processes consisting of ceramic technology, fuel cycle technology, fuels evaluation, fuels fabrication and metals processing; and (3) materials science which includes, ceramic studies, physical metallurgy and properties, radiation effects and microstructural analysis, metastable and superconducting materials, structure and properties of surfaces, theoretical research, and x-ray research and applications. Highlights of the work of the metallographic group and the current status of the High-Temperature Materials Laboratory (HTML) and the Materials and Structures Technology Management Center (MSTMC) aremore » presented. (FS)« less

Current research on public perceptions of nanotechnology

PubMed Central

Besley, J

2010-01-01

This review explores research on public perceptions of nanotechnology. It highlights a recurring emphasis on some researchers’ expectations that there will be a meaningful relationship between awareness of nanotechnology and positive views about nanotechnology. The review, however, also notes that this emphasis is tacitly and explicitly rejected by a range of multivariate studies that emphasize the key roles of non-awareness variables, such as, trust, general views about science, and overall worldview. The review concludes with a discussion of likely future research directions, including the expectation that social scientists will continue to focus on nanotechnology as a unique opportunity to study how individuals assess risk in the context of relatively low levels of knowledge. PMID:22460398

A framework to evaluate research capacity building in health care

PubMed Central

Cooke, Jo

2005-01-01

Background Building research capacity in health services has been recognised internationally as important in order to produce a sound evidence base for decision-making in policy and practice. Activities to increase research capacity for, within, and by practice include initiatives to support individuals and teams, organisations and networks. Little has been discussed or concluded about how to measure the effectiveness of research capacity building (RCB) Discussion This article attempts to develop the debate on measuring RCB. It highlights that traditional outcomes of publications in peer reviewed journals and successful grant applications may be important outcomes to measure, but they may not address all the relevant issues to highlight progress, especially amongst novice researchers. They do not capture factors that contribute to developing an environment to support capacity development, or on measuring the usefulness or the 'social impact' of research, or on professional outcomes. The paper suggests a framework for planning change and measuring progress, based on six principles of RCB, which have been generated through the analysis of the literature, policy documents, empirical studies, and the experience of one Research and Development Support Unit in the UK. These principles are that RCB should: develop skills and confidence, support linkages and partnerships, ensure the research is 'close to practice', develop appropriate dissemination, invest in infrastructure, and build elements of sustainability and continuity. It is suggested that each principle operates at individual, team, organisation and supra-organisational levels. Some criteria for measuring progress are also given. Summary This paper highlights the need to identify ways of measuring RCB. It points out the limitations of current measurements that exist in the literature, and proposes a framework for measuring progress, which may form the basis of comparison of RCB activities. In this way it could contribute to establishing the effectiveness of these interventions, and establishing a knowledge base to inform the science of RCB. PMID:16253133

How Safe and Persistent is your Research? It's all about relationships

NASA Astrophysics Data System (ADS)

Lin, J.

2017-12-01

The relationships between the scholarly resources over the course of the research lifecycle and with the people and places involved are at the core of not only scholarly communications, but the research enterprise. This session will consider the current state of persistent identifiers and their associated metadata in scholarly communications as a critical part of making sure research can be validated. Metadata ensure that the scholarly assets are knitted into the webbing of the research information network. I will discuss this in the context of the growing set of formats and types of research related materials accessible, discoverable, trackable, and reusable. I will highlight the developments in and the importance of expanded standardization and interoperability of scholarly information pertaining to authors, researchers, funders, and others involved in the creation and dissemination of content especially in light of the growing attention towards research integrity and reproducibility.

Health research involving First Nations, Inuit and Métis children and their communities

PubMed Central

Starkes, Jill M; Baydala, Lola T

2014-01-01

Canadian and international guidelines address the ethical conduct of health research in general and the issues affecting Indigenous populations in particular. This statement summarizes, for clinicians and researchers, relevant ethical and practical considerations for health research involving Aboriginal children and youth. While not intended to duplicate findings arising from lengthy collaborative processes, it does highlight ‘wise practices’ that have successfully generated knowledge relevant to, respectful of and useful for Aboriginal children, youth and their communities. Further research on current health issues and inequities should lead to practical, effective and culturally relevant applications. Expanding our knowledge of ways to address the health disparities facing Canada’s Aboriginal children and youth can inform health policy and the provision of services. Community-based participatory research is proposed as a means to achieve this goal. PMID:24596485

The DOE Bioenergy Research Centers: History, Operations, and Scientific Output

DOE PAGES

Slater, Steven C.; Simmons, Blake A.; Rogers, Tamara S.; ...

2015-08-20

Over the past 7 years, the US Department of Energy's Office of Biological and Environmental Research has funded three Bioenergy Research Centers (BRCs). These centers have developed complementary and collaborative research portfolios that address the key technical and economic challenges in biofuel production from lignocellulosic biomass. All three centers have established a close, productive relationship with DOE's Joint Genome Institute (JGI). This special issue of Bioenergy Research samples the breadth of basic science and engineering work required to underpin a diverse, sustainable, and robust biofuel industry. In this report, which was collaboratively produced by all three BRCs, we discuss themore » BRC contributions over their first 7 years to the development of renewable transportation fuels. In additon, we also highlight the BRC research published in the current issue and discuss technical challenges in light of recent progress.« less

An Astrophysical Laboratory: Understanding and Exploiting the Young Massive Cluster Westerlund 1

NASA Astrophysics Data System (ADS)

Clark, S.; Negueruela, I.; Ritchie, B.; Najarro, P.; Langer, N.; Crowther, P.; Bartlett, L.; Fenech, D.; González-Fernández, C.; Goodwin, S.; Lohr, M.; Prinja, R.

2015-03-01

Westerlund 1 provides a unique opportunity to probe the physics of massive stars, from birth to death and beyond, as well as the formation and evolution of a super star cluster that appears destined to evolve into a globular cluster. We highlight the result of current studies of this cluster, its diverse stellar constituents and immediate environment, concluding with a summary of future research avenues enabled by ESO facilities.

An Evidence Based Approach to Designing Medical Support for Long Duration, Interplanetary Missions

NASA Technical Reports Server (NTRS)

Watkins, S. D.; McGrath, T. L.; Bauman, D. K.; Wu, J. H.; Barsten, K. N.; Barr, Y. R.; Kerstman, E. L.

2011-01-01

The Exploration Medical Capability (ExMC) element is one of six elements under NASA's Human Research Program (HRP). The goal of the ExMC element is to address the risk of the "inability to adequately recognize or treat an ill or injured crewmember." This poster highlights the evidence-based approach that the ExMC element has taken to address this goal, and the ExMC element's current areas of interest.

Re-Presenting the Social Construction of Science in Light of the Propositions of Bruno Latour: For a Renewal of the School Conception of Science in Secondary Schools

ERIC Educational Resources Information Center

Richard, Vincent; Bader, Barbara

2010-01-01

Current opinion holds that school science has not been producing the expected outcomes. Highlighted by a considerable body of research, one of the concerns is that young people still mobilize a naive conception of science. Consequently, we must pursue the reflection process concerning ways of renewing the school conception of science so as to…

The Federal Aviation Administration Plan for Research, Engineering and Development. Volume 2. Project Descriptions

DTIC Science & Technology

1989-01-01

managerial areas , including: management and control of the operational requirements of the NAS F& E Plan; preparation, management, and control of the annual... areas (capacity, safety, security, and efficiency), highlights of key programs, and a discussion of the relationships of the RE&D Plan to the NAS F& E ...release of SUA , such as restricted airspace and military operations areas , are currently limited by several factors, including manual interagency

Conformal Electromagnetic Particle in Cell: A Review

DOE PAGES

Meierbachtol, Collin S.; Greenwood, Andrew D.; Verboncoeur, John P.; ...

2015-10-26

We review conformal (or body-fitted) electromagnetic particle-in-cell (EM-PIC) numerical solution schemes. Included is a chronological history of relevant particle physics algorithms often employed in these conformal simulations. We also provide brief mathematical descriptions of particle-tracking algorithms and current weighting schemes, along with a brief summary of major time-dependent electromagnetic solution methods. Several research areas are also highlighted for recommended future development of new conformal EM-PIC methods.

Osteoporotic fractures in older adults

PubMed Central

Colón-Emeric, Cathleen S.; Saag, Kenneth G.

2007-01-01

Osteoporotic fractures are emerging as a major public health problem in the aging population. Fractures result in increased morbidity, mortality and health expenditures. This article reviews current evidence for the management of common issues following osteoporotic fractures in older adults including: (1) thromboembolism prevention; (2) delirium prevention; (3) pain management; (4) rehabilitation; (5) assessing the cause of fracture; and (6) prevention of subsequent fractures. Areas for practice improvement and further research are highlighted. PMID:16979533

A systematic review of current and emergent manipulator control approaches

NASA Astrophysics Data System (ADS)

Ajwad, Syed Ali; Iqbal, Jamshed; Ullah, Muhammad Imran; Mehmood, Adeel

2015-06-01

Pressing demands of productivity and accuracy in today's robotic applications have highlighted an urge to replace classical control strategies with their modern control counterparts. This recent trend is further justified by the fact that the robotic manipulators have complex nonlinear dynamic structure with uncertain parameters. Highlighting the authors' research achievements in the domain of manipulator design and control, this paper presents a systematic and comprehensive review of the state-of-the-art control techniques that find enormous potential in controlling manipulators to execute cuttingedge applications. In particular, three kinds of strategies, i.e., intelligent proportional-integral-derivative (PID) scheme, robust control and adaptation based approaches, are reviewed. Future trend in the subject area is commented. Open-source simulators to facilitate controller design are also tabulated. With a comprehensive list of references, it is anticipated that the review will act as a firsthand reference for researchers, engineers and industrialinterns to realize the control laws for multi-degree of freedom (DOF) manipulators.

Applications of Remote Sensing to Alien Invasive Plant Studies

PubMed Central

Huang, Cho-ying; Asner, Gregory P.

2009-01-01

Biological invasions can affect ecosystems across a wide spectrum of bioclimatic conditions. Therefore, it is often important to systematically monitor the spread of species over a broad region. Remote sensing has been an important tool for large-scale ecological studies in the past three decades, but it was not commonly used to study alien invasive plants until the mid 1990s. We synthesize previous research efforts on remote sensing of invasive plants from spatial, temporal and spectral perspectives. We also highlight a recently developed state-of-the-art image fusion technique that integrates passive and active energies concurrently collected by an imaging spectrometer and a scanning-waveform light detection and ranging (LiDAR) system, respectively. This approach provides a means to detect the structure and functional properties of invasive plants of different canopy levels. Finally, we summarize regional studies of biological invasions using remote sensing, discuss the limitations of remote sensing approaches, and highlight current research needs and future directions. PMID:22408558

Investigating the Aftermath of Terror: Fundamental Outcomes, Methodological Choices, and Future Directions.

PubMed

Gradus, Jaimie L; Marx, Brian P; Sloan, Denise M

2016-06-01

Acts of terrorism are becoming increasingly common throughout the world. These events represent a significant public health concern given the associated health consequences. Although it is clear that terrorist attacks have mental and physical health sequelae, the exact nature and prevalence of these consequences are unclear. Epidemiological research can play an important role in better understanding the mental and physical impact of terrorist attacks. In this editorial, we highlight recent epidemiological research on these terrorism-related health outcomes. We also provide suggestions for how future studies can build on the existing literature and describe ways in which epidemiological methods can be harnessed to extend the current literature. Lastly, we offer recommendations on how to best prepare communities for the aftermath of terrorist attacks, highlighting secondary intervention and prevention strategies. Overall, multilevel strategies are needed to adequately cope with the growing rise of terrorist acts, and these strategies will have to be reassessed as the nature of terrorist attacks changes.

Neurobiological Underpinnings of Math and Reading Learning Disabilities

PubMed Central

Ashkenazi, Sarit; Black, Jessica M.; Abrams, Daniel A.; Hoeft, Fumiko; Menon, Vinod

2013-01-01

The primary goal of this review is to highlight current research and theories describing the neurobiological basis of math (MD), reading (RD), and comorbid math and reading disability (MD+RD). We first describe the unique brain and cognitive processes involved in acquisition of math and reading skills, emphasizing similarities and differences in each domain. Next we review functional imaging studies of MD and RD in children, integrating relevant theories from experimental psychology and cognitive neuroscience to characterize the functional neuroanatomy of cognitive dysfunction in MD and RD. We then review recent research on the anatomical correlates of MD and RD. Converging evidence from morphometry and tractography studies are presented to highlight distinct patterns of white matter pathways which are disrupted in MD and RD. Finally, we examine how the intersection of MD and RD provides a unique opportunity to clarify the unique and shared brain systems which adversely impact learning and skill acquisition in MD and RD, and point out important areas for future work on comorbid learning disabilities. PMID:23572008

Next-generation sequencing in the clinic: promises and challenges.

PubMed

Xuan, Jiekun; Yu, Ying; Qing, Tao; Guo, Lei; Shi, Leming

2013-11-01

The advent of next generation sequencing (NGS) technologies has revolutionized the field of genomics, enabling fast and cost-effective generation of genome-scale sequence data with exquisite resolution and accuracy. Over the past years, rapid technological advances led by academic institutions and companies have continued to broaden NGS applications from research to the clinic. A recent crop of discoveries have highlighted the medical impact of NGS technologies on Mendelian and complex diseases, particularly cancer. However, the ever-increasing pace of NGS adoption presents enormous challenges in terms of data processing, storage, management and interpretation as well as sequencing quality control, which hinder the translation from sequence data into clinical practice. In this review, we first summarize the technical characteristics and performance of current NGS platforms. We further highlight advances in the applications of NGS technologies towards the development of clinical diagnostics and therapeutics. Common issues in NGS workflows are also discussed to guide the selection of NGS platforms and pipelines for specific research purposes. Published by Elsevier Ireland Ltd.

Evidence based practice: laboratory feedback informs forensic specimen collection in NSW.

PubMed

Nittis, Maria; Stark, Margaret

2014-07-01

The importance of having clear, evidence-based guidelines for the taking of forensic samples from suspects detained in police custody (persons of interest) and complainants of crime is essential for forensic practitioners. The need for such guidelines was seen as desirable in New South Wales (NSW) and a working group was set up comprising scientists, practitioners and police. Feedback from the laboratory regarding the results of the specimens taken by forensic practitioners throughout the State was received and analysed. This has resulted in changes to current practice and highlighted the need for further research in this area. It has also highlighted areas that have not changed in response to evidence A quality service demands transparency, process review, relevant research and feedback in order to progress. Examiners need to obtain the results for their cases in order to reinforce the value of the service they provide as well as to monitor and, where necessary, improve their forensic collection skills. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Atmospheric Research 2011 Technical Highlights

NASA Technical Reports Server (NTRS)

2012-01-01

The 2011 Technical Highlights describes the efforts of all members of Atmospheric Research. Their dedication to advancing Earth Science through conducting research, developing and running models, designing instruments, managing projects, running field campaigns, and numerous other activities, is highlighted in this report.

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula.

PubMed

Lau, Dennis H; Volders, Paul G A; Kohl, Peter; Prinzen, Frits W; Zaza, Antonio; Kääb, Stefan; Oto, Ali; Schotten, Ulrich

2015-05-01

Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular medicine. This is in part due to the significant advances made in our understanding and treatment of heart rhythm disorders following more than a century of scientific discoveries and research. More recently, the rapid development of technology in cellular electrophysiology, molecular biology, genetics, computer modelling, and imaging have led to the exponential growth of knowledge in basic cardiac electrophysiology. The paradigm of evidence-based medicine has led to a more comprehensive decision-making process and most likely to improved outcomes in many patients. However, implementing relevant basic research knowledge in a system of evidence-based medicine appears to be challenging. Furthermore, the current economic climate and the restricted nature of research funding call for improved efficiency of translation from basic discoveries to healthcare delivery. Here, we aim to (i) appraise the broad challenges of translational research in cardiac electrophysiology, (ii) highlight the need for improved strategies in the training of translational electrophysiologists, and (iii) discuss steps towards building a favourable translational research environment and culture. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Appraising forensic anthropology in the Philippines: Current status and future directions.

PubMed

Go, Matthew C

2018-07-01

The increasing significance of forensic anthropology in the 21st century, yet unequitable worldwide distribution of expertise, necessitates a stocktaking of the discipline on a local scale. The purpose of this work is to appraise the current state of forensic anthropology in the Philippines and provide the rationale for its further development within the country. Recent efforts in research, education, and legislation that seek to boost Philippine forensic anthropology specifically and forensic sciences generally are highlighted. Furthermore, this work hopes to serve as a springboard for future students, scholars, and practitioners seeking to advance the field in the Philippines. Copyright © 2018 Elsevier B.V. All rights reserved.

Regulation of cytoplasmic mRNA decay

PubMed Central

Schoenberg, Daniel R.; Maquat, Lynne E.

2012-01-01

Discoveries made over the past 20 years highlight the importance of mRNA decay as a means to modulate gene expression and thereby protein production. Up until recently, studies focused largely on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation influences mRNA decay, and the ribonucleases that catalyze decay. Now, current studies have begun to elucidate how the decay process is regulated. This review examines our current understanding of how mammalian-cell mRNA decay is controlled by different signaling pathways and lays out a framework for future research. PMID:22392217

Genome Writing: Current Progress and Related Applications.

PubMed

Wang, Yueqiang; Shen, Yue; Gu, Ying; Zhu, Shida; Yin, Ye

2018-02-01

The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects. Copyright © 2018. Production and hosting by Elsevier B.V.

Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care

PubMed Central

Peto, R

2011-01-01

Misconceptions and ill-founded theories can arise in all areas of science. However, the apparent accessibility of many epidemiology findings and popular interest in the subject can lead to additional misunderstandings. The article below is the third in an occasional series of short editorials highlighting some current misinterpretations of epidemiological findings. Invited authors will be given wide scope in judging the prevalence of the misconception under discussion. We hope that this series will prove instructive to cancer researchers in other disciplines as well as to students of epidemiology. Adrian L Harris and Leo Kinlen PMID:21448174

[Personalised treatment of disorders in the use of alcohol and nicotine].

PubMed

Dom, G; van den Brink, W; Schellekens, A

There is an increasing interest in personalised treatment based on the individual characteristics of the patient in the field of addiction care. To summarise the present state of staging and profiling possibilities within addiction care. A literature review highlighting the current scientific findings and proposing a theoretical model. There are currently an insufficient number of studies to allow for a fully data driven model. However, research identifying biomarkers is growing and some clinically implementable findings can be put forward. a personalised approach in addiction care holds promise. There is an urgent need for better and larger datasets to empirically support models aimed for clinical use.

How can the study of physiological reactivity contribute to our understanding of adversity and resilience processes in development?

PubMed

Obradović, Jelena

2012-05-01

The focus of this article is to present current progress in understanding the interplay among adversity, physiological sensitivity to context, and adaptive functioning, with an emphasis on implications and future directions for resilience researchers. It includes a review of current literature that demonstrates (a) links between various levels of adversity exposure and variability in physiological reactivity, (b) how the interplay between children's physiological reactivity and different sources of risk and adversity relates to variability in adaptive functioning, and (c) various approaches for capturing a more dynamic nature of physiological reactivity and related processes. Throughout, important conceptual and empirical issues are highlighted.

Mastocytosis: current treatment concepts.

PubMed

Worobec, Alexandra S; Metcalfe, Dean D

2002-02-01

An explosion of research on mastocytosis in the last decade has witnessed a greater understanding of the molecular basis of this heterogeneous group of disorders and the conclusion that similar disease phenotypes may indeed be the result of different underlying genotypes. Along with our growing knowledge base of mastocytosis, newer approaches of treating these disorders are becoming available, all under investigational use at this time. This short review highlights the state of the art of current treatment strategies for the different categories of mastocytosis. The future will undoubtedly witness an even greater array of therapeutic options, as we continue to learn more about this enigmatic disease. Copyright 2002 S. Karger AG, Basel

Current Progress in Therapeutic Gene Editing for Monogenic Diseases

PubMed Central

Prakash, Versha; Moore, Marc; Yáñez-Muñoz, Rafael J

2016-01-01

Programmable nucleases allow defined alterations in the genome with ease-of-use, efficiency, and specificity. Their availability has led to accurate and widespread genome engineering, with multiple applications in basic research, biotechnology, and therapy. With regard to human gene therapy, nuclease-based gene editing has facilitated development of a broad range of therapeutic strategies based on both nonhomologous end joining and homology-dependent repair. This review discusses current progress in nuclease-based therapeutic applications for a subset of inherited monogenic diseases including cystic fibrosis, Duchenne muscular dystrophy, diseases of the bone marrow, and hemophilia and highlights associated challenges and future prospects. PMID:26765770

An Overview of Power, Energy Storage, and Conversion Efforts for 2014 SBIR Phases I and II

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for agency projects. NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in development of innovative concepts and technologies to help NASA mission directorates address critical research needs for Agency programs. This report highlights 15 of the innovative SBIR 2014 Phase I and II projects that focus on one of NASA Glenn Research Center's six core competencies-Power, Energy Storage and Conversion. The technologies cover a wide spectrum of applications such as high-radiation-tolerant ceramic voltage isolators, development of hermetic sealing glasses for solid oxide fuel cells, rechargeable lithium metal cells, high-efficiency direct methane solid oxide fuel cell systems, Li metal protection for high-energy space batteries, isolated bidirectional direct current converters for distributed battery energy applications, and high-efficiency rad-hard ultrathin Si photovoltaic cell technology for space. Each article describes an innovation and technical objective and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

Researcher and Author Impact Metrics: Variety, Value, and Context.

PubMed

Gasparyan, Armen Yuri; Yessirkepov, Marlen; Duisenova, Akmaral; Trukhachev, Vladimir I; Kostyukova, Elena I; Kitas, George D

2018-04-30

Numerous quantitative indicators are currently available for evaluating research productivity. No single metric is suitable for comprehensive evaluation of the author-level impact. The choice of particular metrics depends on the purpose and context of the evaluation. The aim of this article is to overview some of the widely employed author impact metrics and highlight perspectives of their optimal use. The h -index is one of the most popular metrics for research evaluation, which is easy to calculate and understandable for non-experts. It is automatically displayed on researcher and author profiles on citation databases such as Scopus and Web of Science. Its main advantage relates to the combined approach to the quantification of publication and citation counts. This index is increasingly cited globally. Being an appropriate indicator of publication and citation activity of highly productive and successfully promoted authors, the h -index has been criticized primarily for disadvantaging early career researchers and authors with a few indexed publications. Numerous variants of the index have been proposed to overcome its limitations. Alternative metrics have also emerged to highlight 'societal impact.' However, each of these traditional and alternative metrics has its own drawbacks, necessitating careful analyses of the context of social attention and value of publication and citation sets. Perspectives of the optimal use of researcher and author metrics is dependent on evaluation purposes and compounded by information sourced from various global, national, and specialist bibliographic databases.

Stem-Cell Therapy Advances in China.

PubMed

Hu, Lei; Zhao, Bin; Wang, Songlin

2018-02-01

Stem-cell therapy is a promising method for treating patients with a wide range of diseases and injuries. Increasing government funding of scientific research has promoted rapid developments in stem-cell research in China, as evidenced by the substantial increase in the number and quality of publications in the past 5 years. Multiple high-quality studies have been performed in China that concern cell reprogramming, stem-cell homeostasis, gene modifications, and immunomodulation. The number of translation studies, including basic and preclinical investigations, has also increased. Around 100 stem-cell banks have been established in China, 10 stem-cell drugs are currently in the approval process, and >400 stem cell-based clinical trials are currently registered in China. With continued state funding, advanced biotechnical support, and the development of regulatory standards for the clinical application of stem cells, further innovations are expected that will lead to a boom in stem-cell therapies. This review highlights recent achievements in stem-cell research in China and discusses future prospects.

Current practice of liquid chromatography-mass spectrometry in metabolomics and metabonomics.

PubMed

Gika, Helen G; Theodoridis, Georgios A; Plumb, Robert S; Wilson, Ian D

2014-01-01

Based on publication and citation numbers liquid chromatography (LC-MS) has become the major analytical technology in the field of global metabolite profiling. This dominance reflects significant investments from both the research community and instrument manufacturers. Here an overview of the approaches taken for LC-MS-based metabolomics research is given, describing critical steps in the realisation of such studies: study design and its needs, specific technological problems to be addressed and major obstacles in data treatment and biomarker identification. The current state of the art for LC-MS-based analysis in metabonomics/metabolomics is described including recent developments in liquid chromatography, mass spectrometry and data treatment as these are applied in metabolomics underlining the challenges, limitations and prospects for metabolomics research. Examples of the application of metabolite profiling in the life sciences focusing on disease biomarker discovery are highlighted. In addition, new developments and future prospects are described. Copyright © 2013 Elsevier B.V. All rights reserved.

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

PubMed Central

Creton, Stuart; Aardema, Marilyn J.; Carmichael, Paul L.; Harvey, James S.; Martin, Francis L.; Newbold, Robert F.; O’Donovan, Michael R.; Pant, Kamala; Poth, Albrecht; Sakai, Ayako; Sasaki, Kiyoshi; Scott, Andrew D.; Schechtman, Leonard M.; Shen, Rhine R.; Tanaka, Noriho; Yasaei, Hemad

2012-01-01

Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of understanding of the mechanistic basis of the assays has limited their acceptance for regulatory purposes. However, recent drivers to find alternative carcinogenicity assessment methodologies, such as the Seventh Amendment to the EU Cosmetics Directive, have fuelled renewed interest in CTAs. Research is currently ongoing to improve the objectivity of the assays, reveal the underlying molecular changes leading to transformation and explore the use of novel cell types. The UK NC3Rs held an international workshop in November 2010 to review the current state of the art in this field and provide directions for future research. This paper outlines the key points highlighted at this meeting. PMID:21852270

Wildfire smoke exposure and human health: Significant gaps in research for a growing public health issue.

PubMed

Black, Carolyn; Tesfaigzi, Yohannes; Bassein, Jed A; Miller, Lisa A

2017-10-01

Understanding the effect of wildfire smoke exposure on human health represents a unique interdisciplinary challenge to the scientific community. Population health studies indicate that wildfire smoke is a risk to human health and increases the healthcare burden of smoke-impacted areas. However, wildfire smoke composition is complex and dynamic, making characterization and modeling difficult. Furthermore, current efforts to study the effect of wildfire smoke are limited by availability of air quality measures and inconsistent air quality reporting among researchers. To help address these issues, we conducted a substantive review of wildfire smoke effects on population health, wildfire smoke exposure in occupational health, and experimental wood smoke exposure. Our goal was to evaluate the current literature on wildfire smoke and highlight important gaps in research. In particular we emphasize long-term health effects of wildfire smoke, recovery following wildfire smoke exposure, and health consequences of exposure in children. Copyright © 2017 Elsevier B.V. All rights reserved.

NASA Self-Assessment of Space Radiation Research

NASA Technical Reports Server (NTRS)

Cucinotta, Francis A.

2010-01-01

Space exploration involves unavoidable exposures to high-energy galactic cosmic rays whose penetration power and associated secondary radiation makes radiation shielding ineffective and cost prohibitive. NASA recognizing the possible health dangers from cosmic rays notified the U.S. Congress as early as 1959 of the need for a dedicated heavy ion accelerator to study the largely unknown biological effects of galactic cosmic rays on astronauts. Information and scientific tools to study radiation health effects expanded over the new decades as NASA exploration programs to the moon and preparations for Mars exploration were carried out. In the 1970 s through the early 1990 s a more than 3-fold increase over earlier estimates of fatal cancer risks from gamma-rays, and new knowledge of the biological dangers of high LET radiation were obtained. Other research has increased concern for degenerative risks to the central nervous system and other tissues at lower doses compared to earlier estimates. In 1996 a review by the National Academy of Sciences Space Science Board re-iterated the need for a dedicated ground-based accelerator facility capable of providing up to 2000 research hours per year to reduce uncertainties in risks projections and develop effective mitigation measures. In 1998 NASA appropriated funds for construction of a dedicated research facility and the NASA Space Radiation Laboratory (NSRL) opened for research in October of 2003. This year marks the 8th year of NSRL research were about 1000 research hours per year have been utilized. In anticipation of the approaching ten year milestone, funded investigators and selected others are invited to participate in a critical self-assessment of NSRL research progress towards NASA s goals in space radiation research. A Blue and Red Team Assessment format has been integrated into meeting posters and special plenary sessions to allow for a critical debate on the progress of the research and major gaps areas. Blue teams will highlight progress and important new knowledge gained. Red teams will challenge the Blue teams on proposed highlights and point to Gaps not considered. We will review the current space radiation Risks and Gaps under investigation at NASA, critical data sets and research highlights anticipated, and possible goals for future research at NSRL.

Narrative Methods and Sociocultural Linguistic Approaches in Facilitating In-depth Understanding of HIV Disclosure in a Cohort of Women and Men in Cape Town, South Africa

PubMed Central

Cooper, Diane; Mantell, Joanne E.; Nywagi, Ntobeko; Cishe, Nomazizi; Austin-Evelyn, Katherine

2016-01-01

The South African National Department of Health has rapidly extended free public-sector antiretroviral treatment for people living with HIV from 2007. Approximately 6 million people are living with HIV in South Africa, with 3.1 million currently on treatment. HIV disclosure stigma has been reduced in high prevalence, generalized epidemic settings, but some remains, including in research interviews. This paper documents the unexpected reactions of people living with HIV to interviewers. It highlights shifts over time from discussing daily events with researchers to later expressing distress and then relief at having an uninvolved, sympathetic person with whom to discuss HIV disclosure. While there are commonalities, women and men had gendered responses to interviewers. These are apparent in men’s uncharacteristic emotional responses and women’s shyness in revealing gendered aspects of HIV acquisition. Both women and men expressed stress at not being allowed or able to fulfill dominant expected masculine or feminine roles. The findings underline the role of research interviewers in study participants confiding and fully expressing their feelings. This greater confidence occurred in follow-up interviews with researchers in busy health facilities, where time of health-care providers is limited. It underlines the methodological value of narrative inquiries with research cohorts. These allowed richer data than cross-sectional interviews. They shaped the questions asked and the process of interview. They revealed participants’ increasing level of agency in expressing feelings that they find important. This research contributes to highlighting pivotal, relational aspects in research between empathetic, experienced researchers and study participants and how participant–researcher relationships progress over time. It highlights ethical dilemmas in roles of researchers as opposed to counselors, raising questions of possible blurring of lines between research and service roles. This requires further research exploration. It additionally underscores the importance of “care for the carer.” Furthermore, it emphasizes that cultural sensitivity to language involves more than merely speaking the words in a language. Culture, humor, dialects, conceptual issues, wordplay, common sense, and respectful attitudes to other languages, resonates. PMID:27242987

Recognition of and intervention in forced marriage as a form of violence and abuse.

PubMed

Chantler, Khatidja

2012-07-01

This paper highlights the importance of recognising forced marriage as a form of violence and draws attention to the interventions that are developing in Europe as a response to forced marriage. The paper highlights the difficulties of conflating all child marriages as forced marriage and discusses the different contexts of childhood in different parts of the globe. The UK is reputed to have the widest range of policy interventions and practice guidance to tackle forced marriage and is therefore used as a case study in this paper, but reference is also made to other countries thus ensuring a wider relevance. The paper's analysis of UK based research studies on forced marriage identifies three key themes: i) lack of adequate reporting of incidents of forced marriage; ii) lack of professional knowledge of forced marriage and their fear of intervention; iii) the tension between conceptualizing forced marriage as purely cultural or as a form of gender based violence. It also highlights the largely legislative responses to forced marriage in Europe; Civil Protection for victims of forced marriage in the UK is discussed and a critical analysis is offered of the increase in marriage and sponsorship age in the UK and in many European countries. Health and clinical issues related to forced marriage are highlighted and the paper calls for further research globally to i) better understand the extent and nature of forced marriage; ii) to evaluate current interventions; iii) to investigate the clinical and potential mental health implications of forced marriage.

Preparing for an epidemic: cancer care in an aging population.

PubMed

Shih, Ya-Chen Tina; Hurria, Arti

2014-01-01

The Institute of Medicine's (IOM) Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population was charged with evaluating and proposing recommendations on how to improve the quality of cancer care, with a specific focus on the aging population. Based on their findings, the IOM committee recently released a report highlighting their 10 recommendations for improving the quality of cancer care. Based on those recommendations, this article highlights ways to improve evidence-based care and addresses rising costs in health care for older adults with cancer. The IOM highlighted three recommendations to address the current research gaps in providing evidence-based care in older adults with cancer, which included (1) studying populations which match the age and health-risk profile of the population with the disease, (2) legislative incentives for companies to include patients that are older or with multiple morbidities in new cancer drug trials, and (3) expansion of research that contributes to the depth and breadth of data available for assessing interventions. The recommendations also highlighted the need to maintain affordable and accessible care for older adults with cancer, with an emphasis on finding creative solutions within both the care delivery system and payment models in order to balance costs while preserving quality of care. The implementation of the IOM's recommendations will be a key step in moving closer to the goal of providing accessible, affordable, evidence-based, high-quality care to all patients with cancer.

Anthropogenic Trace Compounds (ATCs) in aquatic habitats - research needs on sources, fate, detection and toxicity to ensure timely elimination strategies and risk management.

PubMed

Gerbersdorf, Sabine U; Cimatoribus, Carla; Class, Holger; Engesser, Karl-H; Helbich, Steffen; Hollert, Henner; Lange, Claudia; Kranert, Martin; Metzger, Jörg; Nowak, Wolfgang; Seiler, Thomas-Benjamin; Steger, Kristin; Steinmetz, Heidrun; Wieprecht, Silke

2015-06-01

Anthropogenic Trace Compounds (ATCs) that continuously grow in numbers and concentrations are an emerging issue for water quality in both natural and technical environments. The complex web of exposure pathways as well as the variety in the chemical structure and potency of ATCs represents immense challenges for future research and policy initiatives. This review summarizes current trends and identifies knowledge gaps in innovative, effective monitoring and management strategies while addressing the research questions concerning ATC occurrence, fate, detection and toxicity. We highlight the progressing sensitivity of chemical analytics and the challenges in harmonization of sampling protocols and methods, as well as the need for ATC indicator substances to enable cross-national valid monitoring routine. Secondly, the status quo in ecotoxicology is described to advocate for a better implementation of long-term tests, to address toxicity on community and environmental as well as on human-health levels, and to adapt various test levels and endpoints. Moreover, we discuss potential sources of ATCs and the current removal efficiency of wastewater treatment plants (WWTPs) to indicate the most effective places and elimination strategies. Knowledge gaps in transport and/or detainment of ATCs through their passage in surface waters and groundwaters are further emphasized in relation to their physico-chemical properties, abiotic conditions and biological interactions in order to highlight fundamental research needs. Finally, we demonstrate the importance and remaining challenges of an appropriate ATC risk assessment since this will greatly assist in identifying the most urgent calls for action, in selecting the most promising measures, and in evaluating the success of implemented management strategies. Copyright © 2015. Published by Elsevier Ltd.

Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies.

PubMed

Lopez Sanchez, M I G; Crowston, J G; Mackey, D A; Trounce, I A

2016-09-01

Optic neuropathies are an important cause of blindness worldwide. The study of the most common inherited mitochondrial optic neuropathies, Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) has highlighted a fundamental role for mitochondrial function in the survival of the affected neuron-the retinal ganglion cell. A picture is now emerging that links mitochondrial dysfunction to optic nerve disease and other neurodegenerative processes. Insights gained from the peculiar susceptibility of retinal ganglion cells to mitochondrial dysfunction are likely to inform therapeutic development for glaucoma and other common neurodegenerative diseases of aging. Despite it being a fast-evolving field of research, a lack of access to human ocular tissues and limited animal models of mitochondrial disease have prevented direct retinal ganglion cell experimentation and delayed the development of efficient therapeutic strategies to prevent vision loss. Currently, there are no approved treatments for mitochondrial disease, including optic neuropathies caused by primary or secondary mitochondrial dysfunction. Recent advances in eye research have provided important insights into the molecular mechanisms that mediate pathogenesis, and new therapeutic strategies including gene correction approaches are currently being investigated. Here, we review the general principles of mitochondrial biology relevant to retinal ganglion cell function and provide an overview of the major optic neuropathies with mitochondrial involvement, LHON and ADOA, whilst highlighting the emerging link between mitochondrial dysfunction and glaucoma. The pharmacological strategies currently being trialed to improve mitochondrial dysfunction in these optic neuropathies are discussed in addition to emerging therapeutic approaches to preserve retinal ganglion cell function. Copyright © 2016 Elsevier Inc. All rights reserved.

Genetic Toxicology in the 21st Century: Reflections and Future Directions

PubMed Central

Mahadevan, Brinda; Snyder, Ronald D.; Waters, Michael D.; Benz, R. Daniel; Kemper, Raymond A.; Tice, Raymond R.; Richard, Ann M.

2011-01-01

A symposium at the 40th anniversary of the Environmental Mutagen Society, held from October 24–28, 2009 in St. Louis, MO, surveyed the current status and future directions of genetic toxicology. This article summarizes the presentations and provides a perspective on the future. An abbreviated history is presented, highlighting the current standard battery of genotoxicity assays and persistent challenges. Application of computational toxicology to safety testing within a regulatory setting is discussed as a means for reducing the need for animal testing and human clinical trials, and current approaches and applications of in silico genotoxicity screening approaches across the pharmaceutical industry were surveyed and are reported here. The expanded use of toxicogenomics to illuminate mechanisms and bridge genotoxicity and carcinogenicity, and new public efforts to use high-throughput screening technologies to address lack of toxicity evaluation for the backlog of thousands of industrial chemicals in the environment are detailed. The Tox21 project involves coordinated efforts of four U.S. Government regulatory/research entities to use new and innovative assays to characterize key steps in toxicity pathways, including genotoxic and nongenotoxic mechanisms for carcinogenesis. Progress to date, highlighting preliminary test results from the National Toxicology Program is summarized. Finally, an overview is presented of ToxCast™, a related research program of the U.S. Environmental Protection Agency, using a broad array of high throughput and high content technologies for toxicity profiling of environmental chemicals, and computational toxicology modeling. Progress and challenges, including the pressing need to incorporate metabolic activation capability, are summarized. PMID:21538556

2D model of plasma current sheath propagation in a Mather type plasma focus device

NASA Astrophysics Data System (ADS)

Mohamad, Saiful Najmee; Rashid, Natashah Abdul; Halim, Mohd Mahadi; Ali, Jalil

2018-06-01

Plasma focus device is initially developed by two known researchers back in the 1960s, Mather and Filippov. The interest on the research built due to its capability to produce high energetic neutron from a fusion reaction. The relevance of the research in Plasma Focus device remain after decade is because of its competence to produce multi radiation yield and its known physics during nanosecond of plasma compression remain open for discussed. In the recent years, the direction of the plasma research is in device optimisation, where many possible configurations have been present, discuss and highlighting its performance for differences conditions. The significant difference between the electrode configuration is the profile of the dynamics inductance. In this context, this paper comparatively discusses the 1D dynamics model of the plasma current sheath (PSC) propagation axially and radially with the 2D model. The 2D model algorithm for the PSC propagation is developed using macro (Excel) by incorporating a drag force to solve the momentum exchange of the PCS with neutral gas. The discharge current profile of both model successfully calibrated to agree with each other with 2% difference at 1.83 µs after discharge but with an expense of different assumption.

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

PubMed Central

ZHANG, Xiao-Liang; PANG, Wei; HU, Xin-Tian; LI, Jia-Li; YAO, Yong-Gang; ZHENG, Yong-Tang

2014-01-01

Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China’s growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China’s life sciences and pharmaceutical industry, and enhance China’s position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China. PMID:25465081

High temperature, harsh environment sensors for advanced power generation systems

NASA Astrophysics Data System (ADS)

Ohodnicki, P. R.; Credle, S.; Buric, M.; Lewis, R.; Seachman, S.

2015-05-01

One mission of the Crosscutting Technology Research program at the National Energy Technology Laboratory is to develop a suite of sensors and controls technologies that will ultimately increase efficiencies of existing fossil-fuel fired power plants and enable a new generation of more efficient and lower emission power generation technologies. The program seeks to accomplish this mission through soliciting, managing, and monitoring a broad range of projects both internal and external to the laboratory which span sensor material and device development, energy harvesting and wireless telemetry methodologies, and advanced controls algorithms and approaches. A particular emphasis is placed upon harsh environment sensing for compatibility with high temperature, erosive, corrosive, and highly reducing or oxidizing environments associated with large-scale centralized power generation. An overview of the full sensors and controls portfolio is presented and a selected set of current and recent research successes and on-going projects are highlighted. A more detailed emphasis will be placed on an overview of the current research thrusts and successes of the in-house sensor material and device research efforts that have been established to support the program.

Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression

PubMed Central

Hornung, Orla P.; Heim, Christine M.

2013-01-01

This review focuses on current research developments in the study of gene by early life stress (ELS) interactions and depression. ELS refers to aversive experiences during childhood and adolescence such as sexual, physical or emotional abuse, emotional or physical neglect as well as parental loss. Previous research has focused on investigating and characterizing the specific role of ELS within the pathogenesis of depression and linking these findings to neurobiological changes of the brain, especially the stress response system. The latest findings highlight the role of genetic factors that increase vulnerability or, likewise, promote resilience to depression after childhood trauma. Considering intermediate phenotypes has further increased our understanding of the complex relationship between early trauma and depression. Recent findings with regard to epigenetic changes resulting from adverse environmental events during childhood promote current endeavors to identify specific target areas for prevention and treatment schemes regarding the long-term impact of ELS. Taken together, the latest research findings have underscored the essential role of genotypes and epigenetic processes within the development of depression after childhood trauma, thereby building the basis for future research and clinical interventions. PMID:24596569

The rehabilitation engineering research center for the advancement of cognitive technologies.

PubMed

Heyn, Patricia Cristine; Cassidy, Joy Lucille; Bodine, Cathy

2015-02-01

Barring few exceptions, allied health professionals, engineers, manufacturers of assistive technologies (ATs), and consumer product manufacturers have developed few technologies for individuals with cognitive impairments (CIs). In 2004, the National Institute on Disability Rehabilitation Research (NIDRR) recognized the need to support research in this emergent field. They funded the first Rehabilitation Engineering Research Center for the Advancement of Cognitive Technologies (RERC-ACT). The RERC-ACT has since designed and evaluated existing and emerging technologies through rigorous research, improving upon existing AT devices, and creating new technologies for individuals with CIs. The RERC-ACT has contributed to the development and testing of AT products that assist persons with CIs to actively engage in tasks of daily living at home, school, work, and in the community. This article highlights the RERC-ACT's engineering development and research projects and discusses how current research may impact the quality of life for an aging population. © The Author(s) 2014.

2002 Microgravity Materials Science Conference

NASA Technical Reports Server (NTRS)

Gillies, Donald (Editor); Ramachandran, Narayanan (Editor); Murphy, Karen (Editor); McCauley, Dannah (Editor); Bennett, Nancy (Editor)

2003-01-01

The 2002 Microgravity Materials Science Conference was held June 25-26, 2002, at the Von Braun Center, Huntsville, Alabama. Organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Physical Sciences Research Division, NASA Headquarters, and hosted by NASA Marshall Space Flight Center and member institutions under the Cooperative Research in Biology and Materials Science (CORBAMS) agreement, the conference provided a forum to review the current research and activities in materials science, discuss the envisioned long-term goals, highlight new crosscutting research areas of particular interest to the Physical Sciences Research Division, and inform the materials science community of research opportunities in reduced gravity. An abstracts book was published and distributed at the conference to the approximately 240 people attending, who represented industry, academia, and other NASA Centers. This CD-ROM proceedings is comprised of the research reports submitted by the Principal Investigators in the Microgravity Materials Science program.

Federal Child Care Policy. Current and Proposed. Family Impact Seminar (Washington, D.C., April 28, 1989). Meeting Highlights and Background Briefing Report.

ERIC Educational Resources Information Center

Ooms, Theodora; Herendeen, Lisa

The purpose of this policy seminar, one of a series of family impact seminars, was to consider current and proposed policies of the federal government that concern child care. This document provides highlights of presentations by the seminar panelists and a background briefing report prepared before the meeting. The highlights section summarizes:…

Berkeley Lab - Materials Sciences Division

Science.gov Websites

Postdoc Forum Research Highlights Awards Publications Database Events Calendar Newsletter Archive People Database Events Calendar Newsletter Archive Send us your research highlights. Reserch Highlight Template

Cognitive Neuroscience Approaches to Understanding Behavior Change in Alcohol Use Disorder Treatments.

PubMed

Naqvi, Nasir H; Morgenstern, Jon

2015-01-01

Researchers have begun to apply cognitive neuroscience concepts and methods to study behavior change mechanisms in alcohol use disorder (AUD) treatments. This review begins with an examination of the current state of treatment mechanisms research using clinical and social psychological approaches. It then summarizes what is currently understood about the pathophysiology of addiction from a cognitive neuroscience perspective. Finally, it reviews recent efforts to use cognitive neuroscience approaches to understand the neural mechanisms of behavior change in AUD, including studies that use neural functioning to predict relapse and abstinence; studies examining neural mechanisms that operate in current evidence-based behavioral interventions for AUD; as well as research on novel behavioral interventions that are being derived from our emerging understanding of the neural and cognitive mechanisms of behavior change in AUD. The article highlights how the regulation of subcortical regions involved in alcohol incentive motivation by prefrontal cortical regions involved in cognitive control may be a core mechanism that plays a role in these varied forms of behavior change in AUD. We also lay out a multilevel framework for integrating cognitive neuroscience approaches with more traditional methods for examining AUD treatment mechanisms.

Biotransformation and bioactivation reactions - 2015 literature highlights.

PubMed

Baillie, Thomas A; Dalvie, Deepak; Rietjens, Ivonne M C M; Cyrus Khojasteh, S

2016-05-01

Since 1972, Drug Metabolism Reviews has been recognized as one of the principal resources for researchers in pharmacological, pharmaceutical and toxicological fields to keep abreast of advances in drug metabolism science in academia and the pharmaceutical industry. With a distinguished list of authors and editors, the journal covers topics ranging from relatively mature fields, such as cytochrome P450 enzymes, to a variety of emerging fields. We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. Each review begins with a summary of the article followed by our comments on novel aspects of the research and their biological implications. This collection of highlights is not intended to be exhaustive, but rather to be illustrative of recent research that provides new insights or approaches that advance the field of drug metabolism. Abbreviations NAPQI N-acetyl-p-benzoquinoneimine ALDH aldehyde dehydrogenase AO aldehyde oxidase AKR aldo-keto reductase CES carboxylesterase CSB cystathionine β-synthase CSE cystathionine γ-lyase P450 cytochrome P450 DHPO 2,3-dihydropyridin-4-one ESI electrospray FMO flavin monooxygenase GSH glutathione GSSG glutathione disulfide ICPMS inductively coupled plasma mass spectrometry i.p. intraperitoneal MDR multidrug-resistant NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone oaTOF orthogonal acceleration time-of-flight PBK physiologically based kinetic PCP pentachlorophenol SDR short-chain dehydrogenase/reductase SULT sulfotransferase TB tuberculosis.

Research and technology highlights, 1993

NASA Technical Reports Server (NTRS)

1994-01-01

This report contains highlights of the major accomplishments and applications that have been made by Langley researchers and by our university and industry colleagues during the past year. The highlights illustrate both the broad range of the research and technology activities supported by NASA Langley Research Center and the contributions of this work toward maintaining United States leadership in aeronautics and space research. This report also describes some of the Center's most important research and testing facilities.

Microgravity Materials Science Conference 2000. Volume 1

NASA Technical Reports Server (NTRS)

Ramachandran, Narayanan (Editor); Bennett, Nancy (Editor); McCauley, Dannah (Editor); Murphy, Karen (Editor); Poindexter, Samantha (Editor)

2001-01-01

This is Volume 1 of 3 of the 2000 Microgravity Material Science Conference that was held June 6-8 at the Von Braun Center, Huntsville, Alabama. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division (MRD) at NASA Headquarters, and hosted by NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications (AMMSA). It was the fourth NASA conference of this type in the microgravity materials science discipline. The microgravity science program sponsored approx. 200 investigators, all of whom made oral or poster presentations at this conference. In addition, posters and exhibits covering NASA microgravity facilities, advanced technology development projects sponsored by the NASA Microgravity Research Division at NASA Headquarters, and commercial interests were exhibited. The purpose of the conference was to inform the materials science community of research opportunities in reduced gravity and to highlight the Spring 2001 release of the NASA Research Announcement (NRA) to solicit proposals for future investigations. It also served to review the current research and activities in materials science, to discuss the envisioned long-term goals. and to highlight new crosscutting research areas of particular interest to MRD. The conference was aimed at materials science researchers from academia, industry, and government. A workshop on in situ resource utilization (ISRU) was held in conjunction with the conference with the goal of evaluating and prioritizing processing issues in Lunar and Martian type environments. The workshop participation included invited speakers and investigators currently funded in the material science program under the Human Exploration and Development of Space (HEDS) initiative. The conference featured a plenary session every day with an invited speaker that was followed by three parallel breakout sessions in subdisciplines. Attendance was close to 350 people. Posters were available for viewing during the conference and a dedicated poster session was held on the second day. Nanotechnology radiation shielding materials, Space Station science opportunities, biomaterials research, and outreach and educational aspects of the program were featured in the plenary talks. This volume, the first to be released on CD-ROM for materials science, is comprised of the research reports submitted by the Principal Investigators at the conference.

Microgravity Materials Science Conference 2000. Volume 3

NASA Technical Reports Server (NTRS)

Ramachandran, Narayanan; Bennett, Nancy; McCauley, Dannah; Murphy, Karen; Poindexter, Samantha

2001-01-01

This is Volume 3 of 3 of the 2000 Microgravity Materials Science Conference that was held June 6-8 at the Von Braun Center, Huntsville, Alabama. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division (MRD) at NASA Headquarters, and hosted by NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications (AMMSA). It was the fourth NASA conference of this type in the Microgravity materials science discipline. The microgravity science program sponsored 200 investigators, all of whom made oral or poster presentations at this conference- In addition, posters and exhibits covering NASA microgravity facilities, advanced technology development projects sponsored by the NASA Microgravity Research Division at NASA Headquarters, and commercial interests were exhibited. The purpose of the conference was to inform the materials science community of research opportunities in reduced gravity and to highlight the Spring 2001 release of the NASA Research Announcement (NRA) to solicit proposals for future investigations. It also served to review the current research and activities in material,, science, to discuss the envisioned long-term goals. and to highlight new crosscutting research areas of particular interest to MRD. The conference was aimed at materials science researchers from academia, industry, and government. A workshop on in situ resource utilization (ISRU) was held in conjunction with the conference with the goal of evaluating and prioritizing processing issues in Lunar and Martian type environments. The workshop participation included invited speakers and investigators currently funded in the material science program under the Human Exploration and Development of Space (HEDS) initiative. The conference featured a plenary session every day with an invited speaker that was followed by three parallel breakout sessions in subdisciplines. Attendance was close to 350 people, Posters were available for viewing during the conference and a dedicated poster session was held on the second day. Nanotechnology, radiation shielding materials, Space Station science opportunities, biomaterials research, and outreach and educational aspects of the program were featured in the plenary talks. This volume, the first to be released on CD-ROM for materials science, is comprised of the research reports submitted by the Principal Investigators at the conference.

Microgravity Materials Science Conference 2000. Volume 2

NASA Technical Reports Server (NTRS)

Ramachandran, Narayanan (Editor); Bennett, Nancy (Editor); McCauley, Dannah (Editor); Murphy, Karen (Editor); Poindexter, Samantha (Editor)

2001-01-01

This is Volume 2 of 3 of the 2000 Microgravity Materials Science Conference that was held June 6-8 at the Von Braun Center, Huntsville, Alabama. It was organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Microgravity Research Division (MRD) at NASA Headquarters, and hosted by NASA Marshall Space Flight Center and the Alliance for Microgravity Materials Science and Applications (AMMSA). It was the fourth NASA conference of this type in the Microgravity materials science discipline. The microgravity science program sponsored approx. 200 investigators, all of whom made oral or poster presentations at this conference- In addition, posters and exhibits covering NASA microgravity facilities, advanced technology development projects sponsored by the NASA Microgravity Research Division at NASA Headquarters, and commercial interests were exhibited. The purpose of the conference %%,its to inform the materials science community of research opportunities in reduced gravity and to highlight the Spring 2001 release of the NASA Research Announcement (NRA) to solicit proposals for future investigations. It also served to review the current research and activities in material,, science, to discuss the envisioned long-term goals. and to highlight new crosscutting research areas of particular interest to MRD. The conference was aimed at materials science researchers from academia, industry, and government. A workshop on in situ resource utilization (ISRU) was held in conjunction with the conference with the goal of evaluating and prioritizing processing issues in Lunar and Martian type environments. The workshop participation included invited speakers and investigators currently funded in the material science program under the Human Exploration and Development of Space (HEDS) initiative. The conference featured a plenary session every day with an invited speaker that was followed by three parallel breakout sessions in subdisciplines. Attendance was close to 350 people, Posters were available for viewing during the conference and a dedicated poster session was held on the second day. Nanotechnology, radiation shielding materials, Space Station science opportunities, biomaterials research, and outreach and educational aspects of the program were featured in the plenary talks. This volume, the first to be released on CD-ROM for materials science, is comprised of the research reports submitted by the Principal Investigators at the conference.

Protective orders: questions and conundrums.

PubMed

Logan, T K; Shannon, Lisa; Walker, Robert; Faragher, Teri Marie

2006-07-01

Current media portrayal of protective orders is often negative, focusing on weaknesses in how protective orders are obtained and enforced. This review of research findings on protective orders examines issues and suggests areas in need of future research to clarify and improve public policy. More specifically, this review has five main objectives: (a) to provide background information about partner violence and the need for protective orders; (b) to describe what protective orders are, how many women obtain them, and the advantages and disadvantages of obtaining protective orders; (c) to examine characteristics of women who seek protective orders; (d) to explore research on whether protective orders actually increase women's safety; and (e) to highlight opportunities and gaps in the practice and research literature regarding the use of protective orders for women with violent partners or ex-partners.

Economic downturns and population mental health: research findings, gaps, challenges and priorities

PubMed Central

Zivin, K.; Paczkowski, M.; Galea, S.

2013-01-01

Prior research suggests that the current global economic crisis may be negatively affecting population mental health. In that context, this paper has several goals: (1) to discuss theoretical and conceptual explanations for how and why economic downturns might negatively affect population mental health; (2) present an overview of the literature on the relationship between economic recessions and population mental health; (3) discuss the limitations of existing empirical work; and (4) highlight opportunities for improvements in both research and practice designed to mitigate any negative impact of economic declines on the mental health of populations. Research has consistently demonstrated that economic crises are negatively associated with population mental health. How economic downturns influence mental health should be considered in policies such as social protection programs that aim to promote recovery. PMID:20836907

The European Hematology Association Roadmap for European Hematology Research: a consensus document.

PubMed

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-02-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

The European Hematology Association Roadmap for European Hematology Research: a consensus document

PubMed Central

Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

2016-01-01

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

A Modified Goodness-of-Fit Test for the Lognormal Distribution with Unknown Scale and Location Parameters.

DTIC Science & Technology

1986-12-01

Force and other branches of the military are placing an increased emphasis on system reliablity and maintainability. In studying current systems ...used in the research of proposed systems , by predicting MTTF and MTTR of the new parts and thus, predict the reliability of those parts. The statistics...effectiveness of new systems . Aitchison’s book on the lognormal distribution, printed and used by Cambridge University, highlighted the distributions

Evolution of monitoring for Giardia and Cryptosporidium in water.

PubMed

Efstratiou, Artemis; Ongerth, Jerry; Karanis, Panagiotis

2017-10-15

This review describes the evolution of monitoring methodology for Cryptosporidium and Giardia in water since the 1970's. Methods in current use for Giardia and Cryptosporidium in water are highlighted, though attention is given to all available published methods by country and continent. The review is intended to stimulate research leading to future improvements and further developments in monitoring methodology for Giardia, Cryptosporidium and other waterborne protozoan parasites in water. Copyright © 2017. Published by Elsevier Ltd.

Worldwide R&D of Virtual Observatory

NASA Astrophysics Data System (ADS)

Cui, C. Z.; Zhao, Y. H.

2008-07-01

Virtual Observatory (VO) is a data intensive online astronomical research and education environment, taking advantages of advanced information technologies to achieve seamless and uniform access to astronomical information. The concept of VO was introduced in the late 1990s to meet the challenges brought up with data avalanche in astronomy. In the paper, current status of International Virtual Observatory Alliance, technical highlights from world wide VO projects are reviewed, a brief introduction of Chinese Virtual Observatory is given.

Devices used for stabilisation of newborn infants at birth.

PubMed

Roehr, Charles C; O'Shea, Joyce E; Dawson, Jennifer A; Wyllie, Jonathan P

2018-01-01

This review examines devices used during newborn stabilisation. Evidence for their use to optimise the thermal, respiratory and cardiovascular management in the delivery room is presented. Mechanisms of action and rationale of use are described, current developments are presented and areas of future research are highlighted. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Improving the Laboratory Experience for America's High School Students. Hearing before the Subcommittee on Research and Science Education of the Committee on Science and Technology, House of Representatives, One Hundred Tenth Congress, First Session (March 8, 2007). Serial Number 110-9

ERIC Educational Resources Information Center

US House of Representatives, 2007

2007-01-01

This hearing discussed how lack of coordination between laboratory exercises and classroom lectures, inadequately trained teachers, languishing facilities, and current high school organization diminish the value these exercises can have or prohibit them all together, and highlighted how a strong hands-on experience can create scientifically…

2017 Science and Technology Jamboree

NASA Image and Video Library

2017-12-08

NASA Marshall Space Flight Center’s Science and Technology Office held its 11th annual Science and Technology Jamboree Dec. 8 at Marshall Activities Building 4316. A poster session with around 60 poster presentations highlighted current science and technology topics and the innovative projects underway across the center. Here, Debra Needham, right, talks with coworker Sabrina Savage about one of the presentations. Both Needham and Savage are scientists in the Heliophysics & Planetary Science Branch of the Science Research and Projects Division.

Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder

PubMed Central

Gilpin, N. W.; Weiner, J. L.

2016-01-01

Post-traumatic stress disorder (PTSD) and alcohol-use disorder (AUD) are highly comorbid in humans. Although we have some understanding of the structural and functional brain changes that define each of these disorders, and how those changes contribute to the behavioral symptoms that define them, little is known about the neurobiology of comorbid PTSD and AUD, which may be due in part to a scarcity of adequate animal models for examining this research question. The goal of this review is to summarize the current state-of-the-science on comorbid PTSD and AUD. We summarize epidemiological data documenting the prevalence of this comorbidity, review what is known about the potential neurobiological basis for the frequent co-occurrence of PTSD and AUD and discuss successes and failures of past and current treatment strategies. We also review animal models that aim to examine comorbid PTSD and AUD, highlighting where the models parallel the human condition, and we discuss the strengths and weaknesses of each model. We conclude by discussing key gaps in our knowledge and strategies for addressing them: in particular, we (1) highlight the need for better animal models of the comorbid condition and better clinical trial design, (2) emphasize the need for examination of subpopulation effects and individual differences and (3) urge cross-talk between basic and clinical researchers that is reflected in collaborative work with forward and reverse translational impact. PMID:27749004

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications.

PubMed

Han, Ya-Hui; Kankala, Ranjith Kumar; Wang, Shi-Bin; Chen, Ai-Zheng

2018-05-24

In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field. However, ICG still suffers from certain limitations for its utilization as a molecular imaging probe in vivo, such as concentration-dependent aggregation, poor in vitro aqueous stability and photodegradation due to various physicochemical attributes. To overcome these limitations, much research has been dedicated to engineering numerous multifunctional polymeric composites for potential biomedical applications. In this review, we aim to discuss ICG-encapsulated polymeric nanoconstructs, which are of particular interest in various biomedical applications. First, we emphasize some attractive properties of ICG (including physicochemical characteristics, optical properties, metabolic features, and other aspects) and some of its current limitations. Next, we aim to provide a comprehensive overview highlighting recent reports on various polymeric nanoparticles that carry ICG for light-induced therapeutics with a set of examples. Finally, we summarize with perspectives highlighting the significant outcome, and current challenges of these nanocomposites.

Display format, highlight validity, and highlight method: Their effects on search performance

NASA Technical Reports Server (NTRS)

Donner, Kimberly A.; Mckay, Tim D.; Obrien, Kevin M.; Rudisill, Marianne

1991-01-01

Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. Responses to valid applications of highlight were significantly faster than responses to non or invalidly highlighted applications. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. A separate within-subject analysis of variance of display format, highlight validity, and several highlight methods did not reveal a main effect of highlight method. In addition, observed display search times were compared to search time predicted by Tullis' Display Analysis Program. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.

Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives.

PubMed

Lazarević, Tatjana; Rilak, Ana; Bugarčić, Živadin D

2017-12-15

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy. Examples of metal compounds and chelating agents currently in clinical use, clinical trials or preclinical development are highlighted. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Critical appraisal of emergency medicine education research: the best publications of 2013.

PubMed

Farrell, Susan E; Kuhn, Gloria J; Coates, Wendy C; Shayne, Phillip H; Fisher, Jonathan; Maggio, Lauren A; Lin, Michelle

2014-11-01

The objective was to critically appraise and highlight methodologically superior medical education research articles published in 2013 whose outcomes are pertinent to teaching and education in emergency medicine (EM). A search of the English-language literature in 2013 querying Education Resources Information Center (ERIC), PsychINFO, PubMed, and Scopus identified 251 EM-related studies using hypothesis-testing or observational investigations of educational interventions. Two reviewers independently screened all of the publications and removed articles using established exclusion criteria. Six reviewers then independently scored the remaining 43 publications using either a qualitative a or quantitative scoring system, based on the research methodology of each article. Each scoring system consisted of nine criteria. Selected criteria were based on accepted educational review literature and chosen a priori. Both scoring systems used parallel scoring metrics and have been used previously within this annual review. Forty-three medical education research papers (37 quantitative and six qualitative studies) met the a priori criteria for inclusion and were reviewed. Six quantitative and one qualitative study were scored and ranked most highly by the reviewers as exemplary and are summarized in this article. This annual critical appraisal article aims to promote superior research in EM-related education, by reviewing and highlighting seven of 43 major education research studies, meeting a priori criteria, and published in 2013. Common methodologic pitfalls in the 2013 papers are noted, and current trends in medical education research in EM are discussed. © 2014 by the Society for Academic Emergency Medicine.