Presenters at NASP 2013-2016: Where Are the Practitioners?

ERIC Educational Resources Information Center

Aspiranti, Kathleen B.; Jackson, Carrie

2018-01-01

Although one of the main functions of school psychology research is to inform practice, there remains a large research-to-practice gap. Both practitioners and scholars are crucial in ensuring that research within the field is comprehensive and well represented. In the current study, presenter, contributor, and presenter affiliation demographics…

CACAO (THEOBROMA CACAO L.) GENETIC RESOURCES RESEARCH AT THE USDA-ARS TROPICAL AGRICULTURE RESEARCH STATION

USDA-ARS?s Scientific Manuscript database

The current USDA ARS Tropical Agriculture Research Station’s cacao (Theobroma cacao) collection consists of 154 clonally propagated accessions. Each accession is represented by six individual trees grafted on Amelonado rootstocks and planted in a completely randomized block design with three blocks...

Social Representations of Inclusion and Stratification: Ethnographic Research within Two Israeli Elementary Schools

ERIC Educational Resources Information Center

Tuval, Smadar; Orr, Emda

2009-01-01

Based on "Social representations theory", this ethnographic research examines the processes by which two Israeli elementary schools represented some children, but not others, as "weak" students and in need of remedial teaching. This approach differs from most current research regarding children with disabilities, which mainly…

Publishing and Perishing: An Academic Literacies Framework for Investigating Research Productivity

ERIC Educational Resources Information Center

Nygaard, Lynn P.

2017-01-01

The current discourse on research productivity (how much peer-reviewed academic output is published by faculty) is dominated by quantitative research on individual and institutional traits; implicit assumptions are that academic writing is a predominately cognitive activity, and that lack of productivity represents some kind of deficiency.…

Perspectives on hypersonic viscous flow research

NASA Technical Reports Server (NTRS)

Cheng, H. K.

1993-01-01

Issues and advances in current hypersonic flow research perceived to be of interest in theoretical fluid/gas dynamics are reviewed. Particular attention is given to the hypersonic aircraft as waverider, computational methods and theoretical development in the study of viscous interaction, and boundary-layer instability and transition studies. In the present framework the study of viscous hypersonic flow faces transition problems of two kinds which represent the two major areas of current research: the turbulence transition in the high Re range and the transition to the free-molecule limit.

ARRIVE. Annual Review of Research in Vocational Education. Volume One.

ERIC Educational Resources Information Center

Wentling, Tim L., Ed.

This book represents a sampling of current research priorities in vocational education along with suggested directions for further education. In the first of the book's five sections, research efforts related to sex equity in vocational education are summarized by M. Eloise Murray. Both sex equity studies and sex affirmation studies are included…

Current Research on Sleep and Dreams.

ERIC Educational Resources Information Center

National Inst. of Mental Health (DHEW), Bethesda, MD.

This monograph summarizes an extensive body of sleep and dream research in order to indicate the major trends of work in this area. Although a mosaic of disciplines are represented, a spirit of cooperation has made it possible to knit together data which might have remained unrelated. The research reported here provides knowledge about: (1) the…

Current Topics in Early Childhood Education. Volume II.

ERIC Educational Resources Information Center

Katz, Lilian G., Ed.; And Others

The ten papers in this volume present integrative reviews, analyses and syntheses of research and development of current concern to early childhood educators. Four papers represent investigations and reports of programmatic or educational activities. House and Hutchins critically analyze Abt Associates' national evaluation of Project Follow…

Secondary School Students: Prevention Resource Guide.

ERIC Educational Resources Information Center

Alcohol, Drug Abuse, and Mental Health Administration (DHHS/PHS), Rockville, MD. Office for Substance Abuse Prevention.

This prevention resource guide (compiled from a variety of publications and data bases and representing the most currently available information) focuses on secondary school students, and is divided into four sections. The first section contains facts from current research about substance abuse prevention for secondary school students. For…

Who Are We Studying? Sample Diversity in Teaching of Psychology Research

ERIC Educational Resources Information Center

Richmond, Aaron S.; Broussard, Kristin A.; Sterns, Jillian L.; Sanders, Kristina K.; Shardy, Justin C.

2015-01-01

The purpose of the current study was to examine the sample diversity of empirical articles published in four premier teaching of psychology journals from 2008 to 2013. We investigated which demographic information was commonly reported and if samples were ethnically representative and whether gender was representative compared to National…

Stakeholders’ perspectives on access-to-medicines policy and research priorities in Latin America and the Caribbean: face-to-face and web-based interviews

PubMed Central

2014-01-01

Background This study aims to rank policy concerns and policy-related research issues in order to identify policy and research gaps on access to medicines (ATM) in low- and middle-income countries in Latin America and the Caribbean (LAC), as perceived by policy makers, researchers, NGO and international organization representatives, as part of a global prioritization exercise. Methods Data collection, conducted between January and May 2011, involved face-to-face interviews in El Salvador, Colombia, Dominican Republic, and Suriname, and an e-mail survey with key-stakeholders. Respondents were asked to choose the five most relevant criteria for research prioritization and to score policy/research items according to the degree to which they represented current policies, desired policies, current research topics, and/or desired research topics. Mean scores and summary rankings were obtained. Linear regressions were performed to contrast rankings concerning current and desired policies (policy gaps), and current and desired research (research gaps). Results Relevance, feasibility, and research utilization were the top ranked criteria for prioritizing research. Technical capacity, research and development for new drugs, and responsiveness, were the main policy gaps. Quality assurance, staff technical capacity, price regulation, out-of-pocket payments, and cost containment policies, were the main research gaps. There was high level of coherence between current and desired policies: coefficients of determination (R2) varied from 0.46 (Health system structure; r = 0.68, P <0.01) to 0.86 (Sustainable financing; r = 0.93, P <0.01). There was also high coherence between current and desired research on Rational selection and use of medicines (r = 0.71, P <0.05, R2 = 0.51), Pricing/affordability (r = 0.82, P <0.01, R2 = 0.67), and Sustainable financing (r = 0.76, P <0.01, R2 = 0.58). Coherence was less for Health system structure (r = 0.61, P <0.01, R2 = 0.38). Conclusions This study combines metrics approaches, contributing to priority setting methodology development, with country and regional level stakeholder participation. Stakeholders received feedback with the results, and we hope to have contributed to the discussion and implementation of ATM research and policy priorities in LAC. PMID:24965383

Prevalence, correlates, and comorbidity of DSM-IV obsessive-compulsive personality disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

PubMed

Grant, Jon E; Mooney, Marc E; Kushner, Matt G

2012-04-01

Although recognized for over 100 years, there is a relative dearth of empirical research on obsessive compulsive personality disorder (OCPD). The goal of the current study is to present nationally representative findings on prevalence, sociodemographic correlates, and comorbidity of OCPD among men and women. The current study uses nationally representative data to examine sociodemographic correlates and comorbidity of OCPD. Face-to-face interviews were conducted with 43,093 adults in the United States. The prevalence of lifetime OCPD was 7.8%, with rates the same for men and women. OCPD was significantly less common in younger adults and in Asians and Hispanics but was significantly more common in individuals with a high school education or less. When sociodemographic variables and other comorbidities were controlled for, current associations remained significant for all mood and anxiety disorders as well as lifetime personality disorders among both men and women. OCPD is a prevalent personality disorder in the US population and is equally represented in men and women. The results highlight the need for further research to identify common pathophysiological elements common to OCPD and associated disorders. Copyright © 2012 Elsevier Ltd. All rights reserved.

Research on Infancy of Special Relevance for Mental Health. Matrix No. 11A.

ERIC Educational Resources Information Center

Provence, Sally

Research relevant to planning and practice in the area of infant mental health is discussed in this paper. First, three examples of research approaches that reflect current attitudes are given. The first example represents those studies in which there is an effort to closely coordinate physiological and behavioral studies. The second example…

Key Components of Successful Sexuality Education for High Functioning Students with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Greiert, Brittany Sovran

2016-01-01

To date, there is very little existing research on the sexuality education of high functioning adolescents with Autism Spectrum Disorder (ASD) even though current research suggests that 1 in 68 children are diagnosed with ASD (CDC, 2014). Through group consensus of experts in ASD representing families, school-based professionals, and researchers,…

Fundamental constructs in food parenting practices: A content map to guide future research

USDA-ARS?s Scientific Manuscript database

Although research shows that "food-parenting practices" can impact children’s diet and eating habits, current understanding of the impact of specific practices has been limited by inconsistencies in terminology and definitions. This article represents a critical appraisal of food-parenting practices...

Art Education Today: Neither Millennium nor Mirage.

ERIC Educational Resources Information Center

Eisner, Elliot W.

1997-01-01

Reprints the 1966 article as a representative example of thinking about art education during the 1960s. Primarily answers criticisms raised by Victor D'Amico in his attack on the current state of art education, and art education research in particular. Defends this research against charges of irrelevancy and academic indulgence. (MJP)

Annual Review of Psychology, Volume 32, 1981.

ERIC Educational Resources Information Center

Rosenzweig, Mark R., Ed.; Porter, Lyman W., Ed.

This volume contains 19 essays on current research in representative areas of psychology. All of the authors are professors and researchers at universities in the United States. A wide range of topics is discussed. Included among these are human learning and memory; behavioral decision theory; categorization of natural objects; developmental…

Development of insect resistant sunflowers: Updates and challenges

USDA-ARS?s Scientific Manuscript database

Entomology research of the sunflower research unit, USDA-ARS, in Fargo, ND, was discussed in a presentation to a group of producers, industry representatives, and scientists. There are 4 major insect pests for which we have no genetic resistance currently, and the goal of our work is to find genetic...

Defining and Measuring Entrepreneurship for Regional Research: A New Approach

ERIC Educational Resources Information Center

Low, Sarah A.

2009-01-01

In this dissertation, I develop a definition and regional measure of entrepreneurship that will aid entrepreneurship research and economic development policy. My new indicators represent an improvement over current measures of entrepreneurship. The chief contribution of these new indicators is that they incorporate innovation, which others ignore.…

Annual Review of Psychology, Volume 33, 1982.

ERIC Educational Resources Information Center

Rosenzweig, Mark R., Ed.; Porter, Lyman W., Ed.

This volume contains 20 essays on current research in representative areas of psychology. The authors are professors and researchers at universities in the United States, England, Colombia, Poland, Australia, the Netherlands, France, and Canada. A wide range of topics is discussed. Included among these are social psychology of intergroup…

Research on English Teaching and Learning: Taiwan (2004-2009)

ERIC Educational Resources Information Center

Chen, Suchiao; Tsai, Yachin

2012-01-01

This article analyzes research in second/foreign language teaching and learning conducted in Taiwan over the period 2004-2009. Representative articles published in local refereed journals and conference proceedings--not readily accessible outside Taiwan--are reviewed to reflect current trends in English teaching and learning. The main themes…

Graphing Misconceptions and Possible Remedies Using Microcomputer-Based Labs.

ERIC Educational Resources Information Center

Barclay, William L.

Graphing is a common and powerful symbol system for representing concrete data. Yet research has shown that students often have graphical misconceptions about how graphs are related to the concrete event. Currently, the Technical Education Research Center (TERC) is developing microcomputer-based laboratories (MBL) science units that use probes to…

The Current Status and Future of Academic Obstetrics.

ERIC Educational Resources Information Center

Bowers, John Z., Ed.; Purcell, Elizabeth F., Ed.

The state of research in academic obstetrics and its relationship to research in other academic disciplines was addressed in a 1979 conference. Participants included representatives of academic obstetrics, academic pediatrics, and public health. After an introductory discussion by Howard C. Taylor, Jr. on changes in obstetrics in the last 25…

Women in Leader Roles within Higher Education in Bangladesh

ERIC Educational Resources Information Center

Ahad, Lamia Rahman; Gunter, Helen

2017-01-01

Women have long been under-represented in organization leader roles within higher education. Research has identified, mapped and examined the data, with recommendations for change. The research reported in this article adds to current knowledge, and raises methodological questions by focusing on senior female leaders in higher education in…

Tapping Recent Alumni for the Development of Cutting-Edge, Investigative Teaching Laboratory Experiments

ERIC Educational Resources Information Center

Brodl, Mark R.

2005-01-01

This project presents a model for the development of an innovative, highly-experimental teaching laboratory course that centers upon collaborative efforts between recent alumni currently enrolled in Ph. D. programs (consultants) and current faculty. Because these consultants are involved in cutting-edge research, their combined talents represent a…

Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes.

PubMed

Palleria, Caterina; Leporini, Christian; Maida, Francesca; Succurro, Elena; De Sarro, Giovambattista; Arturi, Franco; Russo, Emilio

2016-07-01

Type 2 diabetes mellitus is a complex metabolic disease that can cause serious damage to various organs. Among the best-known complications, an important role is played by cognitive impairment. Impairment of cognitive functioning has been reported both in type 1 and 2 diabetes mellitus. While this comorbidity has long been known, no major advances have been achieved in clinical research; it is clear that appropriate control of blood glucose levels represents the best current (although unsatisfactory) approach in the prevention of cognitive impairment. We have focused our attention on the possible effect on the brain of antidiabetic drugs, despite their effects on blood glucose levels, giving a brief rationale on the mechanisms (e.g. GLP-1, BDNF, ghrelin) that might be involved. Indeed, GLP-1 agonists are currently clinically studied in other neurodegenerative diseases (i.e. Parkinson's and Alzheimer's disease); furthermore, also other antidiabetic drugs have proven efficacy in preclinical studies. Overall, promising results are already available and finding new intervention strategies represents a current need in this field of research. Copyright © 2016 Elsevier Inc. All rights reserved.

Establishing national priorities for Australian occupational health and safety research.

PubMed

Smith, Derek R

2010-01-01

This study aimed to identify current and emerging issues relevant to Occupational Health & Safety (OHS) research in Australia, and to formulate strategic research directions and strategies for the future. A national research forum was held which included leading OHS academics, employer and employee representative groups, as well as executives from state (New South Wales) and national (Safe Work Australia) representative bodies. A modified Delphi technique was used for collecting data in three phases. When ranked according to group consensus, the top three priorities for future OHS research in Australia were identified as being psychosocial and soft tissue injury hazards, work/life issues, and the impact of multiple, long-term exposures. Strategies to enhance collaboration despite limited research funding included the need to focus on complementary skills, to make the best use of Safe Work Australia's role (particularly to link with strategic and operational plans), and to foster closer engagement with research communities. While certain research priorities appear to be similar to those of other countries, the current study did identify some unique characteristics within an Australian context. High quality investigations of these issues should now be considered, in conjunction with greater cooperation between governments, regulators, employers and employee groups for the more effective facilitation of applied OHS research in the coming years.

Wound research funding from alternative sources of federal funds in 2012.

PubMed

Baquerizo Nole, Katherine L; Yim, Elizabeth; Van Driessche, Freya; Davidson, Jeffrey M; Martins-Green, Manuela; Sen, Chandan K; Tomic-Canic, Marjana; Kirsner, Robert S

2014-01-01

Chronic wounds represent a major healthcare burden, costing $25 billion annually, and are associated with high mortality. We previously reported that cutaneous wound healing represented only 0.1% ($29.8 million) of the National Institutes of Health budget. This current study focuses on quantifying the contribution by federal agencies other than the National Institutes of Health for fiscal year 2012. Federal databases including USA Spending, Veterans Affairs, Tracking Accountability in Government Grants Systems, Health Services Research Projects in Progress, and Patient-Centered Outcomes Research Institute, were searched for individual projects addressing wound healing. Twenty-seven projects were identified, totaling funding of $16,588,623 (median: $349,856). Four sponsor institutions accounted for 74% of awarded funds: Department of the Army, National Science Foundation, Department of Veterans Affairs, and Agency for Healthcare Research & Quality. Research projects and cooperative agreements comprised 44% and 37% of awarded grants. New applications and continuing projects represented 52% and 37%. Wound healing represented 0.15% of total medical research funded by the non-National Institutes of Health federal sector. Compared with potential impact on US public health, federal investment in wound research is exiguous. This analysis will draw attention to a disproportionately low investment in wound research and its perils to American public health. © 2014 by the Wound Healing Society.

Responding to violence against women: social science contributions to legal solutions.

PubMed

Portwood, Sharon G; Heany, Julia Finkel

2007-01-01

Violence against women represents a serious problem in America. Not only does intimate partner violence represent a significant threat to women, but it also counts among its victims, children living in the violent household. By its very nature, intimate partner or domestic violence may be approached as either a legal or a social problem. However, there is a shortage of legal approaches that have been informed by sound social science research. One promising framework for developing such integrated responses to intimate partner violence is therapeutic jurisprudence, which encourages legal professionals to work closely with social scientists to develop system responses based on empirical data. Such an approach contrasts sharply with the current practice of developing law based on assumptions, which frequently reflect traditional paternalistic and sexist attitudes toward women. This paper begins by examining the current theories and scientific knowledge on domestic violence with particular emphasis on the supporting data. A theoretical framework for conceptualizing domestic violence characterized as patriarchal terrorism as distinct from common couple violence is examined and offered as a means of explaining inconsistencies in research findings. Following a review of current legal responses to domestic violence, the paper concludes by outlining alternative strategies and recommendations for future efforts that are supported by current theory and research.

The SWAN Scientific Discourse Ontology

PubMed Central

Ciccarese, Paolo; Wu, Elizabeth; Kinoshita, June; Wong, Gwendolyn T.; Ocana, Marco; Ruttenberg, Alan

2015-01-01

SWAN (Semantic Web Application in Neuromedicine) is a project to construct a semantically-organized, community-curated, distributed knowledge base of Theory, Evidence, and Discussion in biomedicine. Unlike Wikipedia and similar approaches, SWAN’s ontology is designed to represent and foreground both harmonizing and contradictory assertions within the total community discourse. Releases of the software, content and ontology will be initially by and for the Alzheimer Disease (AD) research community, with the obvious potential for extension into other disease research areas. The Alzheimer Research Forum, a 4,000-member web community for AD researchers, will host SWAN’s initial public release, currently scheduled for late 2007. This paper presents the current version of SWAN’s ontology of scientific discourse and presents our current thinking about its evolution including extensions and alignment with related communities, projects and ontologies. PMID:18583197

A Review of 25 Years of Research in Bidirectionality in Parent-Child Relationships: An Examination of Methodological Approaches

ERIC Educational Resources Information Center

Paschall, Katherine W.; Mastergeorge, Ann M.

2016-01-01

The concept of bidirectionality represents a process of mutual influence between parent and child, whereby each influences the other as well as the dyadic relationship. Despite the widespread acceptance of bidirectional models of influence, there is still a lack of integration of such models in current research designs. Research on…

Online Recruitment: Feasibility, Cost, and Representativeness in a Study of Postpartum Women.

PubMed

Leach, Liana S; Butterworth, Peter; Poyser, Carmel; Batterham, Philip J; Farrer, Louise M

2017-03-08

Online recruitment is feasible, low-cost, and can provide high-quality epidemiological data. However, little is known about the feasibility of recruiting postpartum women online, or sample representativeness. The current study investigates the feasibility of recruiting a population of postpartum women online for health research and examines sample representativeness. Two samples of postpartum women were compared: those recruited online as participants in a brief survey of new mothers (n=1083) and those recruited face-to-face as part of a nationally representative study (n=579). Sociodemographic, general health, and mental health characteristics were compared between the two samples. Obtaining a sample of postpartum women online for health research was highly efficient and low-cost. The online sample over-represented those who were younger (aged 25-29 years), were in a de facto relationship, had higher levels of education, spoke only English at home, and were first-time mothers. Members of the online sample were significantly more likely to have poor self-rated health and poor mental health than the nationally representative sample. Health differences remained after adjusting for sociodemographic differences. Potential exists for feasible and low-cost e-epidemiological research with postpartum populations; however, researchers should consider the potential influence of sample nonrepresentativeness. ©Liana S Leach, Peter Butterworth, Carmel Poyser, Philip J Batterham, Louise M Farrer. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.03.2017.

Current Status of Programs and Research within the NASA Orbital Debris Program Office

NASA Technical Reports Server (NTRS)

Bacon, Jack

2016-01-01

The NASA Orbital Debris Program Office (ODPO) is the world's longest-standing orbital debris research organization. It supports all aspects of international and US national policy-making related to the orbital environment and to spacecraft life cycle requirements. Representing more than just NASA projects, it is the United States' center of expertise in the field. The office continues to advance research in all aspects of orbital debris, including its measurement, modeling, and risk assessment for both orbital and ground safety concerns. This presentation will highlight current activities and recent progress in all aspects of the ODPO's mission.

Current progress in patient-specific modeling

PubMed Central

2010-01-01

We present a survey of recent advancements in the emerging field of patient-specific modeling (PSM). Researchers in this field are currently simulating a wide variety of tissue and organ dynamics to address challenges in various clinical domains. The majority of this research employs three-dimensional, image-based modeling techniques. Recent PSM publications mostly represent feasibility or preliminary validation studies on modeling technologies, and these systems will require further clinical validation and usability testing before they can become a standard of care. We anticipate that with further testing and research, PSM-derived technologies will eventually become valuable, versatile clinical tools. PMID:19955236

Vision Research Literature May Not Represent the Full Intellectual Range of Autism Spectrum Disorder

PubMed Central

Brown, Alyse C.; Chouinard, Philippe A.; Crewther, Sheila G.

2017-01-01

Sensory, in particular visual processing is recognized as often perturbed in individuals with Autism Spectrum Disorder (ASD). However, in terms of the literature pertaining to visual processing, individuals in the normal intelligence range (IQ = 90–110) and above, are more frequently represented in study samples than individuals who score below normal in the borderline intellectual disability (ID) (IQ = 71–85) to ID (IQ < 70) ranges. This raises concerns as to whether or not current research is generalizable to a disorder that is often co-morbid with ID. Thus, the aim of this review is to better understand to what extent the current ASD visual processing literature is representative of the entire ASD population as either diagnosed or recognized under DSM-5. Our recalculation of ASD prevalence figures, using the criteria of DSM-5, indicates approximately 40% of the ASD population are likely to be ID although searching of the visual processing literature in ASD up to July 2016 showed that only 20% of papers included the ASD with-ID population. In the published literature, the mean IQ sampled was found to be 104, with about 80% of studies sampling from the 96–115 of the IQ range, highlighting the marked under-representation of the ID and borderline ID sections of the ASD population. We conclude that current understanding of visual processing and perception in ASD is not based on the mean IQ profile of the DSM-5 defined ASD population that now appears to lie within the borderline ID to ID range. Give the importance of the role of vision for the social and cognitive processing in ASD, we recommend accurately representing ASD via greater inclusion of individuals with IQ below 80, in future ASD research. PMID:28261072

New targets in the search for preventive and therapeutic agents for botulism.

PubMed

Anniballi, Fabrizio; Lonati, Davide; Fiore, Alfonsina; Auricchio, Bruna; De Medici, Dario; Locatelli, Carlo Alessandro

2014-09-01

Botulism is a severe neuroparalytic disease resulting from exposure to one of the most poisonous toxins to humans. Because of this high potency and the use of toxins as biological weapons, botulism is a public health concern and each case represents an emergency. Current therapy involves respiratory supportive care and anti-toxins administration. As a preventive measure, vaccination against toxins represents an effective strategy but is undesirable due the rarity of botulism and the effectiveness of toxins in treating several neuromuscular disorders. This paper summarizes the current issues in botulism treatment and prevention, highlighting the challenge for future researches.

Current Methods in Health Behavior Research Among U.S. Community College Students: A Review of the Literature

PubMed Central

Pokhrel, Pallav; Little, Melissa A.; Herzog, Thaddeus A.

2016-01-01

The majority of health behavior research involving college students in the United States has focused on 4-year college students. Two-year or community college students have been less studied, although a significant proportion of U.S. undergraduates, primarily those from disadvantaged socioeconomic and/or racial/ethnic background, are enrolled in community colleges. Thus, there is a need to enhance health behavior and health promotion research among community college students. This study systematically reviewed 42 published, peer-reviewed health behavior studies conducted among U.S. community college students in order to determine the current state of research in the area with regard to behaviors studied, research designs used, recruitment and data collection strategies practiced, rates of student participation, and characteristics of the participants represented. Findings identified the methodological limitations of current research and suggested optimal recruitment and data collection methods suitable for various research needs. Findings are discussed in the context of enhancing health behavior research among U.S. community college students. PMID:24227658

Trends and Topics in Autism Spectrum Disorders Research

ERIC Educational Resources Information Center

Matson, Johnny L.; LoVullo, Santino V.

2009-01-01

The field of autism spectrum disorders (ASDs) is expanding at an exponential rate. New topics for study are forming and journals are emerging rapidly to handle the ever-increasing volume of publications. This study was undertaken to provide an overview of past and current research trends. Representative studies were evaluated for type of content…

Designing New Media Education Research: The Materiality of Data, Representation, and Dissemination

ERIC Educational Resources Information Center

Voithofer, Rick

2005-01-01

The current historical moment is marked by the gradual transition from a print culture to a digital new media culture, and this shift carries material effects for how education research contexts are perceived and represented. This discussion uses the concept of materiality to demonstrate how the conceptualization of inquiry through digital…

Research-Based Unit and Lesson Planning: Maximizing Student Achievement

ERIC Educational Resources Information Center

Pagliaro, Marie

2012-01-01

By integrating the best of current research and practice in curriculum planning this book presents that comprehensive topic in a manageable form. Examples throughout are representative of different grade levels and subjects areas. It should be understood at the outset that the content offered for curriculum planning is not a rigid prescriptive…

Botanical reconnaissance of meeks table Research Natural Area, Washington.

Treesearch

Reid Schuller; Shelley. Evans

1986-01-01

A floristic survey of Meeks Table Research Natural Area in the Wenatchee National Forest, Washington, documents 159 vascular plant taxa representing 39 families. This paper provides estimates of abundance by plant community or by other habitat characteristics for all taxa listed. Plant communities are described and mapped based on current vegetation.

A Review of the Literature on Online Developmental Mathematics: Research-Based Recommendations for Practice

ERIC Educational Resources Information Center

Coleman, Sandra Lee; Skidmore, Susan Troncoso; Martirosyan, Nara M.

2017-01-01

In this review of literature, the efficacy of online instruction for developmental mathematics students was explored. Current peer-reviewed articles, representing research from community college settings and written between 1996 and 2015, were reviewed. Based on those studies, several recommendations are offered regarding the online delivery of…

NASA communications technology research and development

NASA Technical Reports Server (NTRS)

Durham, A. F.; Stankiewicz, N.

1979-01-01

The development of a 1978 NASA study to identify technology requirements is surveyed, and its principal conclusions, recommendations, and priorities are summarized. In addition, antenna, traveling wave tube, and solid state amplifier developments representing selected items from the current communications technology development programs at the NASA Lewis Research and Goddard Space Flight Centers are described.

A Bright Promise but a Dim Future. Researchers Examine Potential of Educational Technology.

ERIC Educational Resources Information Center

Pitts, Marcella R., Ed.

Concerns about the current educational technology movement are discussed in these four papers which were presented during a seminar of 20 representatives from 10 Council for Educational Development and Research (CEDaR) member institutions. The first by Marcella Pitts and E. Joseph Schneider provides an overview of the educational technology…

Young Women's Perceptions of Technology and Engineering: Factors Influencing Their Participation in Math, Science and Technology? Research in Engineering and Technology Education

ERIC Educational Resources Information Center

Roue, Leah C.

2007-01-01

The current number of women in technology and engineering only represents a fraction of today's workforce. Technological innovation depends on our nation's best and brightest, representing all segments of our diverse society. Sanders (2005), in talking about women in technology and engineering, stated that women's lack of participation can only be…

Which design for which question? An exploration toward a translation table for comparative effectiveness research.

PubMed

Montori, Victor M; Kim, Simon P; Guyatt, Gordon H; Shah, Nilay D

2012-05-01

In this paper, we explore the relative value that different methods offer in answering some stereotypical comparative effectiveness research questions with the goal of informing development of a 'translation table'--a selection tool for choosing appropriate methods for specific comparative effectiveness research questions. This paper was written as a parallel effort to Greenfield and Kaplan (also in this volume) to support the endeavor described in the manuscript by Tunis et al. (also in this volume). Originally based on four cases, the current article has been shortened to two cases for the current discussion. These cases represent research priorities proposed to orient the work of the Patient-Centered Outcomes Research Institute, comparative clinical effectiveness and comparative health services.

Microgravity Science and Applications. Program Tasks and Bibliography for FY 1993

NASA Technical Reports Server (NTRS)

1994-01-01

An annual report published by the Microgravity Science and Applications Division (MSAD) of NASA is presented. It represents a compilation of the Division's currently-funded ground, flight and Advanced Technology Development tasks. An overview and progress report for these tasks, including progress reports by principal investigators selected from the academic, industry and government communities, are provided. The document includes a listing of new bibliographic data provided by the principal investigators to reflect the dissemination of research data during FY 1993 via publications and presentations. The document also includes division research metrics and an index of the funded investigators. The document contains three sections and three appendices: Section 1 includes an introduction and metrics data, Section 2 is a compilation of the task reports in an order representative of its ground, flight or ATD status and the science discipline it represents, and Section 3 is the bibliography. The three appendices, in the order of presentation, are: Appendix A - a microgravity science acronym list, Appendix B - a list of guest investigators associated with a biotechnology task, and Appendix C - an index of the currently funded principal investigators.

The Sunnel: Engaging Visitors in Solar Research via a Tunnel Through the Sun

NASA Astrophysics Data System (ADS)

DeMuth, Nora H.; Walker, C. E.

2006-12-01

The publicly accessible hallway space inside the McMath-Pierce Solar Telescope building on Kitt Peak has great untapped potential to house a display that would be relevant and understandable to KPNO visitors without the need for mediation or further explanation. An effective display would unite background content on solar physics and astronomy, and information on current solar research techniques and results in an accessible way that would excite and engage visitors. Considering these requirements, we created a concept currently dubbed the Sunnel (for “Sun-tunnel”). The Sunnel consists of two 95by 13-foot murals of the layers of the Sun stretching down the visitor hallway in the McMath-Pierce Solar Telescope. Temperatures of the layers are represented by the colors of the peak in the corresponding black-body curves, and solar features such as sunspots and pressure waves are represented by abstract designs flowing along the walls. A photon path will be laid on the floor using tiles, and several posters highlighting current solar research and background science content relevant to solar research will be displayed on one wall. An audio tour featuring interviews with solar researchers guides visitors along the Sunnel, engaging them and supporting deeper appreciation of the solar research. Installation of the murals is scheduled for early 2007, just in time to celebrate the International Heliophysical Year. DeMuth's research was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation through Scientific Program Order No. 3 (AST-0243875) of the Cooperative Agreement No. AST-0132798 between the Association of Universities for Research in Astronomy (AURA) and the NSF.

Synthesis maps: visual knowledge translation for the CanIMPACT clinical system and patient cancer journeys.

PubMed

Jones, P H; Shakdher, S; Singh, P

2017-04-01

Salient findings and interpretations from the canimpact clinical cancer research study are visually represented in two synthesis maps for the purpose of communicating an integrated presentation of the study to clinical cancer researchers and policymakers. Synthesis maps integrate evidence and expertise into a visual narrative for knowledge translation and communication. A clinical system synthesis map represents the current Canadian primary care and cancer practice systems, proposed as a visual knowledge translation from the mixed-methods canimpact study to inform Canadian clinical research, policy, and practice discourses. Two synthesis maps, drawn together from multiple canimpact investigations and sources, were required to articulate critical differences between the clinical system and patient perspectives. The synthesis map of Canada-wide clinical cancer systems illustrates the relationships between primary care and the full cancer continuum. A patient-centred map was developed to represent the cancer (and primary care) journeys as experienced by breast and colorectal cancer patients.

Avocado (Persea americana) seed as a source of bioactive phytochemicals.

PubMed

Dabas, Deepti; Shegog, Rachel M; Ziegler, Gregory R; Lambert, Joshua D

2013-01-01

The pulp of avocado (Persea americana, Lauraceae) has been reported to have beneficial cardiovascular health effects. Avocado oil is used for dermatological applications and its unsaponifiable portion is reported to have beneficial effects against osteoarthritis. Although the seed represents a considerable percentage of the total fruit, scientific research on the phytochemistry and biological effects of avocado seeds is in the nascent stages,. Currently, the seed represents an under-utilized resource and a waste issue for avocado processors. There is ethno-pharmacological information on the use of seeds for the treatment of health-related conditions, especially in South American countries where avocados are endemic and currently grown on a large scale. Current research has shown that avocado seeds may improve hypercholesterolemia, and be useful in the treatment of hypertension, inflammatory conditions and diabetes. Seeds have also been found to possess insecticidal, fungicidal, and anti-microbial activities. The avocado seeds and rich in phenolic compounds, and these may play a role in the putative health effects. Historically, extracts of avocado seeds were also used as ink for writing and research in our laboratory has explored the potential colorant properties of a polyphenol oxidase-produced colored avocado seed extract. Here, we review the currently-available data on the bioactivity and other functional properties of avocado seeds. We discuss the strength of the available data, the putative active compounds, and potential directions for future studies.

NASA Formal Methods Workshop, 1990

NASA Technical Reports Server (NTRS)

Butler, Ricky W. (Compiler)

1990-01-01

The workshop brought together researchers involved in the NASA formal methods research effort for detailed technical interchange and provided a mechanism for interaction with representatives from the FAA and the aerospace industry. The workshop also included speakers from industry to debrief the formal methods researchers on the current state of practice in flight critical system design, verification, and certification. The goals were: define and characterize the verification problem for ultra-reliable life critical flight control systems and the current state of practice in industry today; determine the proper role of formal methods in addressing these problems, and assess the state of the art and recent progress toward applying formal methods to this area.

Agricultural Change: Consequences for Southern Farms and Rural Communities. Westview Special Studies in Agricultural Science and Policy.

ERIC Educational Resources Information Center

Molnar, Joseph J., Ed.

The 17 articles in this volume are designed to shed light on what farmers are experiencing during the current farm crisis and why. They also examine what current agricultural change means for rural life and rural communities, and what southern farming may be like in the foreseeable future. The articles represent contemporary research and…

The Influence of Wealth and Race in Four-Year College Attendance. Research & Occasional Paper Series: CSHE.18.08

ERIC Educational Resources Information Center

Jez, Su Jin

2008-01-01

College is increasingly essential for economic and social mobility. Current research devotes significant attention to race and socioeconomic factors in college access. Yet wealth's role, as differentiated from income, is largely unexplored. Utilizing a nationally representative dataset, this study analyzes the role of wealth among students who…

The SPARK Programs: A Public Health Model of Physical Education Research and Dissemination

ERIC Educational Resources Information Center

McKenzie, Thomas L.; Sallis, James F.; Rosengard, Paul; Ballard, Kymm

2016-01-01

SPARK [Sports, Play, and Active Recreation for Kids], in its current form, is a brand that represents a collection of exemplary, research-based, physical education and physical activity programs that emphasize a highly active curriculum, on-site staff development, and follow-up support. Given its complexity (e.g., multiple school levels, inclusion…

A Cross-Disciplinary and Cross-Cultural Study of Directives in Discussions and Conclusions of Research Articles

ERIC Educational Resources Information Center

Jalilifar, Alireza; Mehrabi, Khodayar

2014-01-01

The current study provided cross-cultural and cross-disciplinary analyses of the distribution of directives in discussion and conclusion sections of English and Persian research articles (RAs) in disciplines of physics, chemistry, counseling, and sociology, representing hard and soft sciences, respectively. To that aim, 80 RAs from both English…

Experiences, attitudes and barriers towards research amongst junior faculty of Pakistani medical universities.

PubMed

Sabzwari, Saniya; Kauser, Samreen; Khuwaja, Ali Khan

2009-11-16

The developing world has had limited quality research and in Pakistan, research is still in its infancy. We conducted a study to assess the proportion of junior faculty involved in research to highlight their attitude towards research, and identify the factors associated with their research involvement. A cross-sectional study was conducted in four medical universities/teaching hospitals in Pakistan, representing private and public sectors. A pre-tested, self-administered questionnaire was used to collect information from 176 junior faculty members of studied universities/hospitals. Logistic regression analysis was used to identify factors related to attitudes and barriers in research among those currently involved in research with those who were not. Overall, 41.5% of study subjects were currently involved in research. A highly significant factor associated with current research involvement was research training during the post-graduate period (p < 0.001). Other factors associated with current involvement in research were male gender, working in the public sector and previous involvement in research. Overall, a large majority (85.2%) of doctors considered research helpful in their profession and had a positive attitude towards research; nevertheless this positive attitude was more frequently reported by doctors who were currently involved in research compared to those who were not (OR = 4.69; 95% CI = 1.54-14.26). Similarly, a large proportion (83.5%) of doctors considered research difficult to conduct; higher by doctors who were not presently involved in research (OR = 2.74; 95% CI = 1.20-6.22) Less than half of the study participants were currently involved in research. Research output may improve if identified barriers are rectified. Further studies are recommended in this area.

75 FR 14424 - Marine Mammals; File No. 87-1743

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

... number of weaned pups weighed, measured, and tagged in order to study the effects of a current El Ni... conditions related to an El Ni[ntilde]o event represent a unique research opportunity to study climactic...

CDOT rapid debris removal research project.

DOT National Transportation Integrated Search

2014-07-01

Highway debris represents a traffic safety problem that requires a prompt response from state or local transportation : agencies. The most common practice for debris removal currently is for agency personnel to leave their vehicles and : remove the d...

Current Research in European Vocational Education and Human Resource Development. Proceedings of the Programme Presented By the Research Network on Vocational Education and Training (VETNET) at the European Conference of Educational Research (ECER) (3rd, Edinburgh, Scotland, September 20-23, 2000).

ERIC Educational Resources Information Center

Manning, Sabine, Ed.; Raffe, David, Ed.

These 24 papers represent the proceedings of a program presented by the research network on vocational education and training (VET). They include "School-Arranged or Market-Governed Workplace Training?" (Ulla Arnell-Gustafsson); "Prospects for Mutual Learning and Transnational Transfer of Innovative Practice in European VET"…

Patient-derived Xenograft (PDX) Models In Basic and Translational Breast Cancer Research

PubMed Central

Dobrolecki, Lacey E.; Airhart, Susie D.; Alferez, Denis G.; Aparicio, Samuel; Behbod, Fariba; Bentires-Alj, Mohamed; Brisken, Cathrin; Bult, Carol J.; Cai, Shirong; Clarke, Robert B.; Dowst, Heidi; Ellis, Matthew J.; Gonzalez-Suarez, Eva; Iggo, Richard D.; Kabos, Peter; Li, Shunqiang; Lindeman, Geoffrey J.; Marangoni, Elisabetta; McCoy, Aaron; Meric-Bernstam, Funda; Piwnica-Worms, Helen; Poupon, Marie-France; Reis-Filho, Jorge; Sartorius, Carol A.; Scabia, Valentina; Sflomos, George; Tu, Yizheng; Vaillant, François; Visvader, Jane E.; Welm, Alana; Wicha, Max S.

2017-01-01

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational pre-clinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and “Triple-negative” (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward “credentialing” of PDX models as surrogates to represent individual patients for use in pre-clinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research. PMID:28025748

Mobile Healthcare and People with Disabilities: Current State and Future Needs.

PubMed

Jones, Michael; Morris, John; Deruyter, Frank

2018-03-14

Significant health disparities exist between the general population and people with disabilities, particularly with respect to chronic health conditions. Mobile healthcare-the delivery of healthcare via mobile communication devices-is witnessing tremendous growth and has been touted as an important new approach for management of chronic health conditions. At present, little is known about the current state of mobile healthcare for people with disabilities. Early evidence suggests they are not well represented in the growth of mobile healthcare, and particularly the proliferation of mobile health software applications (mHealth apps) for smartphones. Their omission in mHealth could lead to further health disparities. This article describes our research investigating the current state of mHealth apps targeting people with disabilities. Based on a multi-modal approach (literature review, Internet search, survey of disabled smartphone users), we confirm that people with disabilities are under-represented in the growth of mHealth. We identify several areas of future research and development needed to support the inclusion of people with disabilities in the mHealth revolution.

Mobile Healthcare and People with Disabilities: Current State and Future Needs

PubMed Central

Jones, Michael; Morris, John; Deruyter, Frank

2018-01-01

Significant health disparities exist between the general population and people with disabilities, particularly with respect to chronic health conditions. Mobile healthcare—the delivery of healthcare via mobile communication devices—is witnessing tremendous growth and has been touted as an important new approach for management of chronic health conditions. At present, little is known about the current state of mobile healthcare for people with disabilities. Early evidence suggests they are not well represented in the growth of mobile healthcare, and particularly the proliferation of mobile health software applications (mHealth apps) for smartphones. Their omission in mHealth could lead to further health disparities. This article describes our research investigating the current state of mHealth apps targeting people with disabilities. Based on a multi-modal approach (literature review, Internet search, survey of disabled smartphone users), we confirm that people with disabilities are under-represented in the growth of mHealth. We identify several areas of future research and development needed to support the inclusion of people with disabilities in the mHealth revolution. PMID:29538292

Professional representation and the free-lance medical illustrator.

PubMed

Mount, K N; Daugherty, J

1994-01-01

We researched factors related to the success or failure in working relationships between free-lance medical illustrators and artist's representatives. In the fall of 1992, surveys were mailed to 230 medical illustrators; 105 (46%) completed surveys were returned. Respondents were divided into three categories: 1) medical illustrators currently represented, 2) medical illustrators previously represented, and 3) medical illustrators who had never been represented. Comparisons made among illustrators from the three groups included business practices, clientele, experience, and self-promotion techniques. These comparisons revealed notable differences and similarities between the three groups and were subsequently analyzed to identify the characteristics of medical illustrators who would benefit from professional representation.

LANDSCAPE CHARACTERIZATION AND CHANGE DETECTION METHODS DEVELOPMENT RESEARCH (2005-2007)

EPA Science Inventory

The characterization of land-cover (LC) type, extent, and distribution represent important landscape characterization element required for monitoring ecosystem conditions and for primary data input to biogenic emission and atmospheric deposition models. Current spectral-based ch...

78 FR 13319 - Notice of Intent To Request an Extension of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... education system. Focused on national issues, its purpose is to represent the Secretary of Agriculture and... research, extension, and education. Before awards can be made, certain information is required from...

America's Energy Potential: A Summary and Explanation; Committee on Interior and Insular Affairs, U.S. House of Representatives, Ninety-Third Congress, First Session. [Committee Print].

ERIC Educational Resources Information Center

Udall, Morris K.

This report reviews America's current energy position. The energy sources studied include oil and gas, coal, nuclear energy, solar energy, and geothermal energy. Each source is analyzed in terms of current use, technology for extracting and developing the energy, research and development funding, and projections for future consumption and…

An overview of 3D software visualization.

PubMed

Teyseyre, Alfredo R; Campo, Marcelo R

2009-01-01

Software visualization studies techniques and methods for graphically representing different aspects of software. Its main goal is to enhance, simplify and clarify the mental representation a software engineer has of a computer system. During many years, visualization in 2D space has been actively studied, but in the last decade, researchers have begun to explore new 3D representations for visualizing software. In this article, we present an overview of current research in the area, describing several major aspects like: visual representations, interaction issues, evaluation methods and development tools. We also perform a survey of some representative tools to support different tasks, i.e., software maintenance and comprehension, requirements validation and algorithm animation for educational purposes, among others. Finally, we conclude identifying future research directions.

Families Today: A Research Sampler on Families and Children. Volume II. NIMH Science Monographs 1.

ERIC Educational Resources Information Center

Corfman, Eunice, Ed.

The second of two volumes, this book contains 21 studies of children and families. Selections, grouped into three sections, are intended to provide a representative sample of current research, including case studies and less formal reports. The first section reports on families in distress. Articles focus on adults who were antisocial children,…

Review of Doctoral Research on Second Language Teaching and Learning in Spain (2008-2010)

ERIC Educational Resources Information Center

Serrano, Raquel; Miralpeix, Imma

2013-01-01

This paper reviews a selection of doctoral theses on language learning and teaching completed in Spain between 2008 and 2010. A total of 16 theses have been identified as representative--in terms of the topics under investigation and the methodology employed--of the doctoral research undertaken in Spain. Current topics include the development of…

In vivo confocal microscopy in dermatology: from research to clinical application

NASA Astrophysics Data System (ADS)

Ulrich, Martina; Lange-Asschenfeldt, Susanne

2013-06-01

Confocal laser scanning microscopy (CLSM) represents an emerging technique for the noninvasive histomorphological analysis of skin in vivo and has shown its applicability for dermatological research as well as its value as an adjunct tool in the clinical management of skin cancer patients. Herein, we aim to give an overview on the current clinical indications for CLSM in dermatology and also highlight the diverse applications of CLSM in dermatological research.

Human Factors Research for Space Exploration: Measurement, Modeling, and Mitigation

NASA Technical Reports Server (NTRS)

Kaiser, Mary K.; Allen, Christopher S.; Barshi, Immanuel; Billman, Dorrit; Holden, Kritina L.

2010-01-01

As part of NASA's Human Research Program, the Space Human Factors Engineering Project serves as the bridge between Human Factors research and Human Spaceflight applications. Our goal is to be responsive to the operational community while addressing issues at a sufficient level of abstraction to ensure that our tools and solutions generalize beyond the point design. In this panel, representatives from four of our research domains will discuss the challenges they face in solving current problems while also enabling future capabilities.

Lessons from obesity prevention for the prevention of mental disorders: the primordial prevention approach.

PubMed

Hayward, Joshua; Jacka, Felice N; Waters, Elizabeth; Allender, Steven

2014-09-10

Emerging evidence supports a relationship between risk factors for obesity and the genesis of the common mental disorders, depression and anxiety. This suggests common mental disorders should be considered as a form of non-communicable disease, preventable through the modification of lifestyle behaviours, particularly diet and physical activity. Obesity prevention research since the 1970's represents a considerable body of knowledge regarding strategies to modify diet and physical activity and so there may be clear lessons from obesity prevention that apply to the prevention of mental disorders. For obesity, as for common mental disorders, adolescence represents a key period of vulnerability. In this paper we briefly discuss relationships between modifiable lifestyle risk factors and mental health, lifestyle risk factor interventions in obesity prevention research, the current state of mental health prevention, and the implications of current applications of systems thinking in obesity prevention research for lifestyle interventions. We propose a potential focus for future mental health promotion interventions and emphasise the importance of lessons available from other lifestyle modification intervention programmes.

Alternatives to the 15% Rule

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broderick, Robert Joseph; Quiroz, Jimmy Edward; Reno, Matthew J.

2015-11-01

The third solicitation of the California Solar Initiative (CSI) Research, Development, Demonstration and Deployment (RD&D) Program established by the California Public Utility Commission (CPUC) is supporting the Electric Power Research Institute (EPRI), National Renewable Energy Laboratory (NREL), and Sandia National Laboratories (SNL) with collaboration from Pacific Gas and Electric (PG&E), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E), in research to improve the Utility Application Review and Approval process for interconnecting distributed energy resources to the distribution system. Currently this process is the most time - consuming of any step on the path to generating power onmore » the distribution system. This CSI RD&D solicitation three project has completed the tasks of collecting data from the three utilities, clustering feeder characteristic data to attain representative feeders, detailed modeling of 16 representative feeders, analysis of PV impacts to those feeders, refinement of current screening processes, and validation of those suggested refinements. In this report each task is summarized to produce a final summary of all components of the overall project.« less

Damping Resonant Current in a Spark-Gap Trigger Circuit to Reduce Noise

DTIC Science & Technology

2009-06-01

DAMPING RESONANT CURRENT IN A SPARK- GAP TRIGGER CIRCUIT TO REDUCE NOISE E. L. Ruden Air Force Research Laboratory, Directed Energy Directorate, AFRL...REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Damping Resonant Current In A Spark- Gap Trigger Circuit To Reduce Noise 5a...thereby triggering 2 after delay 0, is 1. Each of the two rail- gaps (represented by 2) is trig- gered to close after the spark- gap (1) in the

NASA's Single-Pilot Operations Technical Interchange Meeting: Proceedings and Findings

NASA Technical Reports Server (NTRS)

Comerford, Doreen; Brandt, Summer L.; Lachter, Joel B.; Wu, Shu-Chieh; Mogford, Richard H.; Battiste, Vernol; Johnson, Walter W.

2013-01-01

Researchers at the National Aeronautics and Space Administration (NASA) Ames Research Center and Langley Research Center are jointly investigating issues associated with potential concepts, or configurations, in which a single pilot might operate under conditions that are currently reserved for a minimum of two pilots. As part of early efforts, NASA Ames Research Center hosted a technical interchange meeting in order to gain insight from members of the aviation community regarding single-pilot operations (SPO). The meeting was held on April 10-12, 2012 at NASA Ames Research Center. Professionals in the aviation domain were invited because their areas of expertise were deemed to be directly related to an exploration of SPO. NASA, in selecting prospective participants, attempted to represent various relevant sectors within the aviation domain. Approximately 70 people representing government, academia, and industry attended. A primary focus of this gathering was to consider how tasks and responsibilities might be re-allocated to allow for SPO.

Bioengineered vascular constructs as living models for in vitro cardiovascular research.

PubMed

Wolf, Frederic; Vogt, Felix; Schmitz-Rode, Thomas; Jockenhoevel, Stefan; Mela, Petra

2016-09-01

Cardiovascular diseases represent the most common cause of morbidity and mortality worldwide. In this review, we explore the potential of bioengineered vascular constructs as living models for in vitro cardiovascular research to advance the current knowledge of pathophysiological processes and support the development of clinical therapies. Bioengineered vascular constructs capable of recapitulating the cellular and mechanical environment of native vessels represent a valuable platform to study cellular interactions and signaling cascades, test drugs and medical devices under (patho)physiological conditions, with the additional potential benefit of reducing the number of animals required for preclinical testing. Copyright © 2016 Elsevier Ltd. All rights reserved.

Windows on the human body--in vivo high-field magnetic resonance research and applications in medicine and psychology.

PubMed

Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph S; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

2010-01-01

Analogous to the evolution of biological sensor-systems, the progress in "medical sensor-systems", i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given.

NATO/CCMS PILOT STUDY ON CLEAN PRODUCTS & PROCESSES

EPA Science Inventory

Led by the United States, represented by the U.S. Environmental Protection Agency's (EPA's) National Risk Management Research Laboratory, the Pilot Study on Clean Products and Processes was instituted to create an international forum where current trends, developments, and expert...

EMISSION TRADING - CURRENT STATUS AND FUTURE PROSPECTS (R828631)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

DISCRETE TUNNELING CURRENT FLUCTUATIONS IN METAL-WATER-METAL TUNNEL JUNCTIONS. (R829623)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

DENSITY CURRENT INTRUSIONS IN AN ICE-COVERED URBAN LAKE. (R824801)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

EQUILIBRIUM STRUCTURE AND DYNAMICS OF THE CALIFORNIA CURRENT SYSTEM. (R825381)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

EMERGING TECHNOLOGY SUMMARY: ELECTRO-PURE ALTERNATING CURRENT ELECTROCOAGULATION

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program was authorized as part of the 1986 amendments to the Superfund legislation. It represents a joint effort between the U.S. Environmental Protection Agency’s (EPA) Office of Research and Development and Office of Solid W...

Working Women. A Bibliography.

ERIC Educational Resources Information Center

Florida State Univ., Tallahassee. Center for Instructional Development and Services.

This bibliography draws together currently available sources on the subject of the changes that women are bringing about in the workplace. The 127 citations from ERIC and other databases include curriculum guides, congressional hearing reports, conference papers, journal articles, and research reports. Two articles, representative of current…

Early Childhood Inclusion in Israel

ERIC Educational Resources Information Center

Al-Yagon, Michal; Aram, Dorit; Margalit, Malka

2016-01-01

This article describes conceptual aspects, current policies and practices, and research representing the Israeli perspective regarding early childhood inclusion (ECI) at preschool ages (3-6 years). We review legislative, historical, attitudinal, philosophical, practical, empirical, and cultural issues regarding ECI in Israel. Finally, we focus on…

Current clinical research in orthodontics: a perspective.

PubMed

Baumrind, Sheldon

2006-10-01

This essay explores briefly the approach of the Craniofacial Research Instrumentation Laboratory to the systematic and rigorous investigation of the usual outcome of orthodontic treatment in the practices of experienced clinicians. CRIL's goal is to produce a shareable electronic database of reliable, valid, and representative data on clinical practice as an aid in the production of an improved environment for truly evidence-based orthodontic treatment.

Meeting current and future conservation challenges through the synthesis of long-term silviculture and range management research

Treesearch

Mary Beth Adams; Joe NcNeel

2010-01-01

The Experimental Forests and Ranges (EFRs) of the Forest Service, U.S. Department of Agriculture were established to represent major forest vegetation types of the United States, to provide guidelines for management of those forests and ranges, and to serve as "outdoor classrooms" for land managers to learn how to better manage their forests. Research data...

MedRapid--medical community & business intelligence system.

PubMed

Finkeissen, E; Fuchs, H; Jakob, T; Wetter, T

2002-01-01

currently, it takes at least 6 months for researchers to communicate their results. This delay is caused (a) by partial lacks of machine support for both representation as well as communication and (b) by media breaks during the communication process. To make an integrated communication between researchers and practitioners possible, a general structure for medical content representation has been set up. The procedure for data entry and quality management has been generalized and implemented in a web-based authoring system. The MedRapid-system supports the medical experts in entering their knowledge into a database. Here, the level of detail is still below that of current medical guidelines representation. However, the symmetric structure for an area-wide medical knowledge representation is highly retrievable and thus can quickly be communicated into daily routine for the improvement of the treatment quality. In addition, other sources like journal articles and medical guidelines can be references within the MedRapid-system and thus be communicated into daily routine. The fundamental system for the representation of medical reference knowledge (from reference works/books) itself is not sufficient for the friction-less communication amongst medical staff. Rather, the process of (a) representing medical knowledge, (b) refereeing the represented knowledge, (c) communicating the represented knowledge, and (d) retrieving the represented knowledge has to be unified. MedRapid will soon support the whole process on one server system.

Semantic Technologies and Bio-Ontologies.

PubMed

Gutierrez, Fernando

2017-01-01

As information available through data repositories constantly grows, the need for automated mechanisms for linking, querying, and sharing data has become a relevant factor both in research and industry. This situation is more evident in research fields such as the life sciences, where new experiments by different research groups are constantly generating new information regarding a wide variety of related study objects. However, current methods for representing information and knowledge are not suited for machine processing. The Semantic Technologies are a set of standards and protocols that intend to provide methods for representing and handling data that encourages reusability of information and is machine-readable. In this chapter, we will provide a brief introduction to Semantic Technologies, and how these protocols and standards have been incorporated into the life sciences to facilitate dissemination and access to information.

Three Human Attributes

ERIC Educational Resources Information Center

Eaves, Ronald C.; Williams, Thomas O., Jr.

2004-01-01

This study represents a beginning step in research that may ultimately show that the multitudes of human behavior that educators currently encounter may be reduced to three broad human attributes: arousal, affect, and cognition. The resulting simplicity should lead to improved understanding and better decision making by practitioners. Four…

Making science high impact to inform decision-making: Using boundary objects for aquatic research

EPA Science Inventory

The St. Louis River represents a complex natural resource management problem. Current ecosystem management decisions must address extensive sediment remediation and habitat restoration goals for the lower river and associated port, as well as recreational users who value differen...

Principal Leadership of Data Team Protocols within a Professional Learning Community

ERIC Educational Resources Information Center

Chambers, Charmelle

2014-01-01

The following document represents a Problem Based Learning Project (PBL) focusing on school leadership practices leading to increased student achievement. Current research findings indicate effective principals recognize the importance of building teacher capacity through promoting collaborative team work. School principals effectively leading…

Introduction to Acoustics

NASA Astrophysics Data System (ADS)

Rossing, Thomas

This brief introduction may help to persuade the reader that acoustics covers a wide range of interesting topics. It is impossible to cover all these topics in a single handbook, but we have attempted to include a sampling of hot topics that represent current acoustical research, both fundamental and applied.

Ecosystem services and cooperative fisheries research to address a complex fishery problem

EPA Science Inventory

The St. Louis River represents a complex fishery management problem. Current fishery management goals have to be developed taking into account bi-state commercial, subsistence and recreational fisheries which are valued for different characteristics by a wide range of anglers, as...

"Coming from a different place": Partnerships between consumers and health services for system change.

PubMed

Scholz, Brett; Bocking, Julia; Banfield, Michelle; Platania-Phung, Chris; Happell, Brenda

2018-05-18

The aim of the current study is to explore whether and how the expectations of consumers to be 'representative' influences consumers' ability to contribute to health services partnerships. Health standards call for services to partner with consumers in service development and governance. While existing research criticises the assumption that individual mental health consumers working with mental health services must be representative of consumers more broadly, research has yet to explore whether this requirement exists for consumers of other health services. Requiring individual consumers to be representative of consumers more broadly marginalises and limits consumer involvement. A qualitative, exploratory design was employed. Consumers (n=6), clinicians (n=7), and health managers (n=5) were interviewed about consumer participation in health services. Data analysis was conducted through the lens of social exchange theory, and informed by discursive psychological principles. The current study extends existing literature within mental health, finding that consumers of other health services are also held responsible for representing broader communities. Data also suggested that a requirement to be representative would marginalise consumers with a passion to bring about change in health systems. The findings suggest that organisations might need a culture change so that individual consumers are not expected to be representative of consumers more broadly, and that participation be made more accessible for diverse groups of consumers. Given the role that nurses might play as allies to consumers within health services, the findings of this study contribute to knowledge about the expectations placed on consumers and the ways that nurses might advocate for better partnerships. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

National Institutes of Health Funding for Obstructive Sleep Apnea: An Opportunity for Otolaryngologists.

PubMed

Gouveia, Christopher J; Qureshi, Hannan A; Kern, Robert C; Shintani Smith, Stephanie

2015-10-01

To describe current levels and trends of funding for the National Institutes of Health (NIH) in obstructive sleep apnea (OSA) and to recognize the current status of otolaryngologists in OSA research. Scientometric analysis. The NIH RePORTER database was queried for the search term "obstructive sleep apnea" for all available years. Sex, degree, academic department, NIH funding source, geography, funding totals and years, and h-index of principal investigators (PIs) were collected and summarized. A total of 397 projects spanning 1242 total funding years were funded. Of the 273 individual PIs, 33.3% (91/273) were female. Regarding credentials, 52.4% of PIs (143/273) were MD or MD/PhD, and 41.0% (112/273) were PhD alone. Academic departments of PIs were most often medicine (34.1%), pediatrics (12.1%), cell biology/physiology (10.6%), and psychiatry (7.7%). Seven otolaryngology faculty members had received NIH funding for OSA research (2.6% of total PIs) since 2000. They accounted for 8 grants (0.25% of total grants) and $7,235,729 (1.5% of total dollars) of research funding. Despite studies showing increasing levels of OSA surgery being performed and major areas of research and clinical opportunity, otolaryngologists represent a small minority of OSA research funding. This information may help direct our specialty when setting priorities regarding research funding, as research into the basic science and clinical management of OSA represents a broad and interdisciplinary pursuit. © American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.

Windows on the Human Body – in Vivo High-Field Magnetic Resonance Research and Applications in Medicine and Psychology

PubMed Central

Moser, Ewald; Meyerspeer, Martin; Fischmeister, Florian Ph. S.; Grabner, Günther; Bauer, Herbert; Trattnig, Siegfried

2010-01-01

Analogous to the evolution of biological sensor-systems, the progress in “medical sensor-systems”, i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectroscopy (MRS), which enable non-invasive, in vivo acquisition of morphological, functional, and metabolic information from the human body with unsurpassed quality. Recent achievements in high and ultra-high field MR (at 3 and 7 Tesla) are described, and representative research applications in Medicine and Psychology in Austria are discussed. Finally, an overview of current and prospective research in multi-modal imaging, potential clinical applications, as well as current limitations and challenges is given. PMID:22219684

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1992-01-01

This publication represents the NASA research and technology program for FY92. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOP's is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and technology objectives and plans: Summary fiscal year 1991

NASA Technical Reports Server (NTRS)

1991-01-01

This publication represents the NASA research and technology program for FY 1991. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, industry, and in universities. The first section contains citations and abstracts of the RTOP's and is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1993-01-01

This publication represents the NASA research and technology program for FY-93. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOP's is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1988-01-01

This publication represents the NASA research and technology program for FY88. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1989-01-01

This publication represents the NASA research and technology program for FY89. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1985-01-01

This publication represents the NASA research and technology program for FY 1985. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1987-01-01

This publication represents the NASA research and technology program for FY87. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Biomonitoring of intermittent rivers and ephemeral streams in Europe: Current practice and priorities to enhance ecological status assessments.

PubMed

Stubbington, Rachel; Chadd, Richard; Cid, Núria; Csabai, Zoltán; Miliša, Marko; Morais, Manuela; Munné, Antoni; Pařil, Petr; Pešić, Vladimir; Tziortzis, Iakovos; Verdonschot, Ralf C M; Datry, Thibault

2018-03-15

Intermittent rivers and ephemeral streams (IRES) are common across Europe and dominate some Mediterranean river networks. In all climate zones, IRES support high biodiversity and provide ecosystem services. As dynamic ecosystems that transition between flowing, pool, and dry states, IRES are typically poorly represented in biomonitoring programmes implemented to characterize EU Water Framework Directive ecological status. We report the results of a survey completed by representatives from 20 European countries to identify current challenges to IRES status assessment, examples of best practice, and priorities for future research. We identify five major barriers to effective ecological status classification in IRES: 1. the exclusion of IRES from Water Framework Directive biomonitoring based on their small catchment size; 2. the lack of river typologies that distinguish between contrasting IRES; 3. difficulties in defining the 'reference conditions' that represent unimpacted dynamic ecosystems; 4. classification of IRES ecological status based on lotic communities sampled using methods developed for perennial rivers; and 5. a reliance on taxonomic characterization of local communities. Despite these challenges, we recognize examples of innovative practice that can inform modification of current biomonitoring activity to promote effective IRES status classification. Priorities for future research include reconceptualization of the reference condition approach to accommodate spatiotemporal fluctuations in community composition, and modification of indices of ecosystem health to recognize both taxon-specific sensitivities to intermittence and dispersal abilities, within a landscape context. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

China-U.S. Relations: Current Issues and Implications for U.S. Policy

DTIC Science & Technology

2009-07-10

Trade Representative (USTR) filed a case against China in the WTO in December 2008 charging that the PRC’s “Famous Chinese” brand program amounted to...Association of America, Inc. has charged that China may be blocking the import of American films , creating more opportunities for pirated versions...Relations: Current Issues and Implications for U.S. Policy Congressional Research Service 10 consumers. In 2007, the USTR filed several cases in

The NASA Electronic Parts and Packaging (NEPP) Program - Presentation to Korean Aerospace Research Institute

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Sampson, Michael J.

2016-01-01

This presentation will provide basic information about NASA's Electronic Parts and Packaging Program (NEPP), for sharing with representatives of the South Korean Aerospace Research Institute (KARI) as part of a larger presentation by Headquarters Office of Safety and Mission Assurance. The NEPP information includes mission and goals, history of the program, basic focus areas, strategies, deliverables and some examples of current tasks.

Exploring the Engagement of Lecturers with Learning and Teaching Agendas through a Focus on Their Beliefs about, and Experience with, Student Support

ERIC Educational Resources Information Center

Bailey, Richard

2013-01-01

This article reports on research which aimed to examine academic staff attitudes to, and beliefs regarding the role and efficacy of, support for students' broader learning needs once engaged in degree study. It is contended here that the perspective of teachers represents a gap in current pedagogical research. The study has two complementary aims:…

Digested disorder

PubMed Central

DeForte, Shelly; Reddy, Krishna D; Uversky, Vladimir N

2013-01-01

The current literature on intrinsically disordered proteins is overwhelming. To keep interested readers up to speed with this literature, we continue a “Digested Disorder” project and represent a series of reader’s digest type articles objectively representing the research papers and reviews on intrinsically disordered proteins. The only 2 criteria for inclusion in this digest are the publication date (a paper should be published within the covered time frame) and topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the period of April, May, and June of 2013. The papers are grouped hierarchically by topics they cover, and for each of the included paper a short description is given on its major findings. PMID:28516028

Digested disorder: Quarterly intrinsic disorder digest (April-May-June, 2013).

PubMed

DeForte, Shelly; Reddy, Krishna D; Uversky, Vladimir N

2013-01-01

The current literature on intrinsically disordered proteins is overwhelming. To keep interested readers up to speed with this literature, we continue a "Digested Disorder" project and represent a series of reader's digest type articles objectively representing the research papers and reviews on intrinsically disordered proteins. The only 2 criteria for inclusion in this digest are the publication date (a paper should be published within the covered time frame) and topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the period of April, May, and June of 2013. The papers are grouped hierarchically by topics they cover, and for each of the included paper a short description is given on its major findings.

An Educational System for the Seventies.

ERIC Educational Resources Information Center

Shelly (E.F.) and Co., New York, NY.

An Educational System for the Seventies (ES '70) is a research and demonstration program representing a broad scope of activity that cuts across every aspect of education. Four main categories of activities comprise the substance of the current effort: staff development, instructional managment and career guidance, school management, and…

GROUND WATER MONITORING AND SAMPLING: MULTI-LEVEL VERSUS TRADITIONAL METHODS WHATS WHAT?

EPA Science Inventory

After years of research and many publications, the question still remains: What is the best method to collect representative ground water samples from monitoring wells? Numerous systems and devices are currently available for obtaining both multi-level samples as well as traditi...

Costs and Benefits of Family Involvement in Homework

ERIC Educational Resources Information Center

Van Voorhis, Frances Landis

2011-01-01

Homework represents one research-based instructional strategy linked to student achievement. However, challenges abound with its current practice. This paper presents the results of three 2-year longitudinal interventions of the Teachers Involve Parents in Schoolwork (TIPS) homework program in elementary mathematics, middle school language arts,…

Update 76: Selected Recent Works in the Social Sciences.

ERIC Educational Resources Information Center

Pike, Mary L., Ed.; Lusignan, Louise, Ed.

This is a selected bibliography of current reference and acquisition tools in the social sciences. The tools include sourcebooks, dictionaries, indexes, conference proceedings, special bibliographies, directories, research reports, and journals. Most citations represent works published since 1970 and new editions of important earlier works.…

Advances in statistics

Treesearch

Howard Stauffer; Nadav Nur

2005-01-01

The papers included in the Advances in Statistics section of the Partners in Flight (PIF) 2002 Proceedings represent a small sample of statistical topics of current importance to Partners In Flight research scientists: hierarchical modeling, estimation of detection probabilities, and Bayesian applications. Sauer et al. (this volume) examines a hierarchical model...

[New Paradigms? Current Trends within National and International Psychotherapy Research].

PubMed

Strauß, Bernhard

2015-09-01

This article is devoted to the question which paradigms currently determine psychotherapy and psychotherapy research, and if there are indicators of paradigm changes in this field. The question of the efficacy and effectiveness (including the effectiveness of a transfer of psychotherapeutic knowledge to service) is specifically focussed as well as the question of the central therapeutic factors and the significance of the person of the therapist. It is argued that there are really some signals of a paradigm switch, with a turn away from controlled outcome research, representing only a minor part of patients in need of psychotherapy, towards a more specific process oriented research, also considering differential effects of the therapist. The most prominent indicator of a paradigm change is reflected by an increasing influence of patient oriented psychotherapy research which - consequently - should also be supported by the insurances as well as the funding organisations. © Georg Thieme Verlag KG Stuttgart · New York.

Current Challenges in Geothermal Reservoir Simulation

NASA Astrophysics Data System (ADS)

Driesner, T.

2016-12-01

Geothermal reservoir simulation has long been introduced as a valuable tool for geothermal reservoir management and research. Yet, the current generation of simulation tools faces a number of severe challenges, in particular in the application for novel types of geothermal resources such as supercritical reservoirs or hydraulic stimulation. This contribution reviews a number of key problems: Representing the magmatic heat source of high enthalpy resources in simulations. Current practice is representing the deeper parts of a high enthalpy reservoir by a heat flux or temperature boundary condition. While this is sufficient for many reservoir management purposes it precludes exploring the chances of very high enthalpy resources in the deepest parts of such systems as well as the development of reliable conceptual models. Recent 2D simulations with the CSMP++ simulation platform demonstrate the potential of explicitly including the heat source, namely for understanding supercritical resources. Geometrically realistic incorporation of discrete fracture networks in simulation. A growing number of simulation tools can, in principle, handle flow and heat transport in discrete fracture networks. However, solving the governing equations and representing the physical properties are often biased by introducing strongly simplifying assumptions. Including proper fracture mechanics in complex fracture network simulations remains an open challenge. Improvements of the simulating chemical fluid-rock interaction in geothermal reservoirs. Major improvements have been made towards more stable and faster numerical solvers for multicomponent chemical fluid rock interaction. However, the underlying thermodynamic models and databases are unable to correctly address a number of important regions in temperature-pressure-composition parameter space. Namely, there is currently no thermodynamic formalism to describe relevant chemical reactions in supercritical reservoirs. Overcoming this unsatisfactory situation requires fundamental research in high temperature physical chemistry rather than further numerical development.

Current efforts on developing an HWIL synthetic environment for LADAR sensor testing at AMRDEC

NASA Astrophysics Data System (ADS)

Kim, Hajin J.; Cornell, Michael C.; Naumann, Charles B.

2005-05-01

Efforts in developing a synthetic environment for testing LADAR sensors in a hardware-in-the-loop simulation are continuing at the Aviation and Missile Research, Engineering, and Development Center (AMRDEC) of the U.S. Army Research, Engineering and Development Command (RDECOM). Current activities have concentrated on developing the optical projection hardware portion of the synthetic environment. These activities range from system level design down to component level testing. Of particular interest have been schemes for generating the optical signals representing the individual pixels of the projection. Several approaches have been investigated and tested with emphasis on operating wavelength, intensity dynamic range and uniformity, and flexibility in pixel waveform generation. This paper will discuss some of the results from these current efforts at RDECOM's Advanced Simulation Center (ASC).

Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 2

PubMed Central

Murray, Iain R.; LaPrade, Robert F.; Musahl, Volker; Geeslin, Andrew G.; Zlotnicki, Jason P.; Mann, Barton J.; Petrigliano, Frank A.

2016-01-01

Rotator cuff tears are common and result in considerable morbidity. Tears within the tendon substance or at its insertion into the humeral head represent a considerable clinical challenge because of the hostile local environment that precludes healing. Tears often progress without intervention, and current surgical treatments are inadequate. Although surgical implants, instrumentation, and techniques have improved, healing rates have not improved, and a high failure rate remains for large and massive rotator cuff tears. The use of biologic adjuvants that contribute to a regenerative microenvironment have great potential for improving healing rates and function after surgery. This article presents a review of current and emerging biologic approaches to augment rotator cuff tendon and muscle regeneration focusing on the scientific rationale, preclinical, and clinical evidence for efficacy, areas for future research, and current barriers to advancement and implementation. PMID:27099865

SOME CURRENT TRENDS IN NUMERICAL METHODS FOR TRANSIENT ACOUSTIC AND ELASTIC WAVES IN MULTIDIMENSIONAL INHOMOGENEOUS MEDIA. (R825225)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Evaluation of current Louisiana flexible pavement structures using PMS data and new mechanistic-empirical pavement design guide.

DOT National Transportation Integrated Search

2012-04-01

The new Mechanistic-Empirical Pavement Design Guide (MEPDG) developed under the National Cooperative Highway Research Program (NCHRP) Project 1-37A represents a major change as compared to the 1993 AASHTO Pavement Design Guide. The MEPDG provides a r...

Cognitive Load Theory--Sometimes Less Is More

ERIC Educational Resources Information Center

Taylor, Cody

2013-01-01

The following paper represents review of the literature examining the current research related to cognitive load theory and more specifically the negative aspects of the redundant on-screen text. The authors describe working and long-term memory and how both factor into human learning through the facilitation of knowledge transfer. Limited working…

The integration of epigenetics and genetics in nutrition research for CVD risk factors

USDA-ARS?s Scientific Manuscript database

There is increasing evidence documenting gene-by-environment (G x E) interactions for CVD related traits. However, the underlying mechanisms are still unclear. DNA methylation may represent one of such potential mechanisms. The objective of this review paper is to summarise the current evidence supp...

Evaluation of current Louisiana flexible pavement structures using PMS data and new mechanistic-empirical pavement design guide : tech summary.

DOT National Transportation Integrated Search

2012-04-01

The new Mechanistic-Empirical Pavement Design Guide (MEPDG) developed under the National Cooperative Highway : Research Program (NCHRP) Project 1-37A represents a major change as compared to the 1993 AASHTO Pavement : Design Guide. MEPDG provides a r...

Narrative Review of Pedagogical Interventions on Nutrition Knowledge and Weight Prejudice

ERIC Educational Resources Information Center

Werkhoven, Thea; Cotton, Wayne; Dudley, Dean

2016-01-01

Objectives: To synthesize and review pedagogically informed interventions that increase nutrition knowledge and decrease weight prejudice among practicing and pre-service health and education professionals. These factors have been addressed as separate entities in intervention-based research and this represents a gap in current literature. The…

Concepts for Care: 20 Essays on Infant/Toddler Development and Learning

ERIC Educational Resources Information Center

Lally, J. Ronald, Ed.; Mangione, Peter L., Ed.; Greenwald, Deborah, Ed.

2006-01-01

Leading experts in infant/toddler development have contributed succinct essays drawn from research, theory, clinical case studies, and carefully documented practice. Each essay represents current thinking in the field of infant/toddler development and care. Individually and as a collection, the essays provide a springboard for reflection,…

Adolescents and the Media.

ERIC Educational Resources Information Center

Strasburgber, Victor C., Ed.; Comstock, George A., Ed.

1993-01-01

In the 1990s, the media represent the single most easily modifiable influence on children and adolescents. This series of articles offers medically oriented practitioners a review of current research on the influence of the media on children and adolescents. The 13 articles are: (1) "Children, Adolescents, and the Media: Five Crucial…

The Sources of Innovation and Creativity

ERIC Educational Resources Information Center

Adams, Karlyn

2005-01-01

This document represents a comprehensive summary of current research and theory on the sources of innovation and creativity, both in individuals and organizations. Based on the recurring concepts in the existing literature, the document concludes with some recommendations for how education systems can best foster these attributes in students. Both…

2017: beginning of a new era for Chlamydia research in China and the rest of the world.

PubMed

Fan, Huizhou; Zhong, Guangming

2018-01-01

The First Chinese Chlamydia Research Meeting was held in Lanzhou, China in May 2017, 60 years after the disclosure of reproducible isolation of Chlamydia trachomatis by (Fei-fan Tang). We report current state of the Chlamydia research community in China, and briefly review recent progress in Chlamydia vaccinology. The meeting represents a new milestone for Chlamydia research in the country. The Chinese Chlamydia Research Society (CCRS) was formed during the meeting. Future meetings will be held biennially and should facilitate collaboration of Chinese researchers with their domestic and international colleagues. Copyright © 2017 Institut Pasteur. All rights reserved.

Proceedings of Selected Research Paper Presentations at the 1988 Convention of the Association for Educational Communications and Technology and Sponsored by the Research and Theory Division (10th, New Orleans, Louisiana, January 14-19, 1988).

ERIC Educational Resources Information Center

Simonson, Michael R., Ed.; Frederick, Jacqueline K., Ed.

1988-01-01

The 54 papers in this volume represent some of the most current thinking in educational communications and technology. Individual papers address the following topics: feedback in computer-assisted instruction (CAI); cognitive style and cognitive strategies in CAI; persuasive film-making; learning strategies; computer technology and children's word…

Proceedings of Selected Research Paper Presentations at the Convention of the Association for Educational Communications and Technology and Sponsored by the Research and Theory Division (11th, Dallas, Texas, February 1-5, 1989).

ERIC Educational Resources Information Center

Simonson, Michael R., Ed.; Frey, Diane, Ed.

1989-01-01

The 46 papers is this volume represent some of the most current thinking in educational communications and technology. Individual papers address the following topics: gender differences in the selection of elective computer science courses and in the selection of non-traditional careers; instruction for individuals with different cognitive styles;…

A Decade of Denial: Teens and AIDS in America. A Report of the Select Committee on Children, Youth, and Families. Together with Additional Views and Dissenting Minority Views. House of Representatives, 102d Congress, 2nd Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

Based on hearings, current research, and interviews with experts, including researchers, medical and service providers, and Acquired Immune Deficiency Syndrome (AIDS) educators, this Select Committee report assesses the impact of the Human Immunodeficiency Virus (HIV) epidemic on youth and identifies strategies policymakers and program planners…

Partnering with patients in translational oncology research: ethical approach.

PubMed

Mamzer, Marie-France; Duchange, Nathalie; Darquy, Sylviane; Marvanne, Patrice; Rambaud, Claude; Marsico, Giovanna; Cerisey, Catherine; Scotté, Florian; Burgun, Anita; Badoual, Cécile; Laurent-Puig, Pierre; Hervé, Christian

2017-04-08

The research program CARPEM (cancer research and personalized medicine) brings together the expertise of researchers and hospital-based oncologists to develop translational research in the context of personalized or "precision" medicine for cancer. There is recognition that patient involvement can help to take into account their needs and priorities in the development of this emerging practice but there is currently no consensus about how this can be achieved. In this study, we developed an empirical ethical research action aiming to improve patient representatives' involvement in the development of the translational research program together with health professionals. The aim is to promote common understanding and sharing of knowledge between all parties and to establish a long-term partnership integrating patient's expectations. Two distinct committees were settled in CARPEM: an "Expert Committee", gathering healthcare and research professionals, and a "Patient Committee", gathering patients and patient representatives. A multidisciplinary team trained in medical ethics research ensured communication between the two committees as well as analysis of discussions, minutes and outputs from all stakeholders. The results highlight the efficiency of the transfer of knowledge between interested parties. Patient representatives and professionals were able to identify new ethical challenges and co-elaborate new procedures to gather information and consent forms for adapting to practices and recommendations developed during the process. Moreover, included patient representatives became full partners and participated in the transfer of knowledge to the public via conferences and publications. Empirical ethical research based on a patient-centered approach could help in establishing a fair model for coordination and support actions during cancer research, striking a balance between the regulatory framework, researcher needs and patient expectations. Our approach addresses the concept of translational ethics as a way to handle the main remaining gap between combining care and research activities in the medical pathway and the existing framework.

Regenerative medicine in Brazil: small but innovative.

PubMed

McMahon, Dominique S; Singer, Peter A; Daar, Abdallah S; Thorsteinsdóttir, Halla

2010-11-01

Although Brazil has received attention for conducting one of the world's largest stem cell clinical trials for heart disease, little has been published regarding Brazil's regenerative medicine (RM) sector. Here we present a comprehensive case study of RM in Brazil, including analysis of the current activity, the main motivations for engaging in RM and the remaining challenges to development in this field. Our case study is primarily based on semi-structured interviews with experts on RM in Brazil, including researchers, policymakers, clinicians, representatives of firms and regulators. Driven by domestic health needs and strategic government support, Brazil is producing innovative RM research, particularly for clinical research in cardiology, orthopedics, diabetes and neurology. We describe the main RM research currently taking place in Brazil, as well as some of the economic, regulatory and policy events that have created a favorable environment for RM development. Brazilian RM researchers need to overcome several formidable challenges to research: research funding is inconsistent, importation of materials is costly and slow, and weak linkages between universities, hospitals and industry impede translational research. Although Brazil's contribution to the RM sector is small, its niche emphasis on clinical applications may become of global importance, particularly if Brazil manages to address the challenges currently impinging on RM innovation.

High-Speed Research: Sonic Boom, volume 2

NASA Technical Reports Server (NTRS)

Darden, Christine M. (Compiler)

1992-01-01

A High-Speed Sonic Boom Workshop was held at NASA Langley Research Center on February 25-27, 1992. The purpose of the workshop was to make presentations on current research activities and accomplishments and to assess progress in the area of sonic boom since the program was initiated in FY-90. Twenty-nine papers were presented during the 2-1/2 day workshop. Attendees included representatives from academia, industry, and government who are actively involved in sonic-boom research. Volume 2 contains papers related to low sonic-boom design and analysis using both linear theory and higher order computational fluid dynamics (CFD) methods.

Review and Design of Low-Dose Bacillus anthracis Inhalation ...

EPA Pesticide Factsheets

Report In July 2011, EPA NHSRC sponsored a Review and Design of Low-Dose Bacillus anthracis Inhalation Exposures meeting to review the research done to date and to identify gaps that future research should address regarding low-dose exposures. This effort brought together many organizations across the country, including EPA’s program offices, federal government agencies and laboratories, academia, and the private sector. Participants of the conference shared knowledge, explored differing opinions, and expanded understanding of the current state of research for low-dose exposure and future research needs. This report represents a summary of the presentations and discussions during the meeting.

Disentangling the relationship between child maltreatment and violent delinquency: using a nationally representative sample.

PubMed

Yun, Ilhong; Ball, Jeremy D; Lim, Hyeyoung

2011-01-01

This study uses the National Longitudinal Study of Adolescents (Add Health) data, a nationally representative sample of adolescents, to disentangle the relationship between child maltreatment and violent delinquency. Also examined are potential moderating effects of gender, socioeconomic status (SES), and religiosity on the association between child maltreatment and violent delinquency. Contrary to prior research findings, the current analyses reveal that physical abuse is not associated with future violent delinquency, whereas sexual abuse and neglect predict violent delinquency significantly. The current study also did not reveal any moderating effects of gender, SES, and religiosity on the association between maltreatment and violent delinquency. Interpretations of these findings are presented, drawing on the properties of the national probability sample compared to the findings of most prior studies that used localized samples.

Multigrid techniques for unstructured meshes

NASA Technical Reports Server (NTRS)

Mavriplis, D. J.

1995-01-01

An overview of current multigrid techniques for unstructured meshes is given. The basic principles of the multigrid approach are first outlined. Application of these principles to unstructured mesh problems is then described, illustrating various different approaches, and giving examples of practical applications. Advanced multigrid topics, such as the use of algebraic multigrid methods, and the combination of multigrid techniques with adaptive meshing strategies are dealt with in subsequent sections. These represent current areas of research, and the unresolved issues are discussed. The presentation is organized in an educational manner, for readers familiar with computational fluid dynamics, wishing to learn more about current unstructured mesh techniques.

High-Speed Research: Sonic Boom, volume 1

NASA Technical Reports Server (NTRS)

Darden, Christine M. (Compiler)

1992-01-01

A High-Speed Sonic Boom Workshop was held at LaRC of Feb. 25-27, 1992. The purpose was to make presentations on current research activities and accomplishments and to assess progress in the area of sonic boom since the program was initiated in FY-90. Twenty-nine papers were presented during the 2-1/2 day workshop. Attendees included representatives from academia, industry, and government who are actively involved in sonic-boom research. Volume 1 contains papers related to atmospheric effects on the sonic-boom signature during propagation and on acceptability studies.

Inclusiveness program - a SWOT analysis

NASA Astrophysics Data System (ADS)

Dósa, M.; Szegő, K.

2017-09-01

The Inclusiveness Program was created with the aim to integrate currently under-represented countries into the mainstream of European planetary research. Main stages of the working plan include setting up a database containing all the research institutes and universities where astronomical or geophysical research is carried out. It is necessary to identify their problems and needs. Challenging part of the project is to find exact means that help their work in a sustainable way. Strengths, weaknesses, opportunities and threats of the program were identified based on feedback from the inclusiveness community. Our conclusions, further suggestions are presented.

Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death.

PubMed

Al-Khatib, Sana M; Sanders, Gillian D; Bigger, J Thomas; Buxton, Alfred E; Califf, Robert M; Carlson, Mark; Curtis, Anne; Curtis, Jeptha; Fain, Eric; Gersh, Bernard J; Gold, Michael R; Haghighi-Mood, Ali; Hammill, Stephen C; Healey, Jeff; Hlatky, Mark; Hohnloser, Stefan; Kim, Raymond J; Lee, Kerry; Mark, Daniel; Mianulli, Marcus; Mitchell, Brent; Prystowsky, Eric N; Smith, Joseph; Steinhaus, David; Zareba, Wojciech

2007-06-01

Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are of proven predictive value in this population. Efforts in risk stratification for SCD have focused primarily on predicting SCD in patients with known structural heart disease. Despite the ubiquity of tests that have been purported to predict SCD vulnerability in such patients, there is little consensus on which test, in addition to the left ventricular ejection fraction, should be used to determine which patients will benefit from an implantable cardioverter defibrillator. On July 20 and 21, 2006, a group of experts representing clinical cardiology, cardiac electrophysiology, biostatistics, economics, and health policy were joined by representatives of the US Food and Drug administration, Centers for Medicare Services, Agency for Health Research and Quality, the Heart Rhythm Society, and the device and pharmaceutical industry for a round table meeting to review current data on strategies of risk stratification for SCD, to explore methods to translate these strategies into practice and policy, and to identify areas that need to be addressed by future research studies. The meeting was organized by the Duke Center for the Prevention of SCD at the Duke Clinical Research Institute and was funded by industry participants. This article summarizes the presentations and discussions that occurred at that meeting.

A Bibliometric Analysis of the Top 100 Most Cited Chronotype Research Papers

PubMed Central

2017-01-01

Bibliometric indices are a widely used measure of research impact. The aim of the current study was to identify and characterise the top one hundred most-cited research articles in the topic of chronotype research. A search of the Thomson Reuters Web of Science database returned 974 eligible articles (published between 1990 and 2016). Citations for the 100 most-cited articles ranged between 438 and 29. The most represented journal was Chronobiology International (n = 30). Nearly 50% of articles originated in Germany and the U.S. The bibliometrics reported identify key publications and provide insight into trends within the topic of chronotype research.

Reassessing the Representative Heuristic of the Plywood Ballistic Mannequin Used in Live-Fire Testing

DTIC Science & Technology

2015-04-01

currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) April 2015 2. REPORT TYPE Final 3...the materials of construction of the current plywood ballistic mannequin (or manikin) should be more closely controlled and 2) to revise the US Army...Inappropriate 33 Appendix B. The American Plywood Association (APA) Wood Species Grouping 37 Appendix C. US Army Ballistic Research Laboratory (BRL) Plywood

Statistical learning and language acquisition

PubMed Central

Romberg, Alexa R.; Saffran, Jenny R.

2011-01-01

Human learners, including infants, are highly sensitive to structure in their environment. Statistical learning refers to the process of extracting this structure. A major question in language acquisition in the past few decades has been the extent to which infants use statistical learning mechanisms to acquire their native language. There have been many demonstrations showing infants’ ability to extract structures in linguistic input, such as the transitional probability between adjacent elements. This paper reviews current research on how statistical learning contributes to language acquisition. Current research is extending the initial findings of infants’ sensitivity to basic statistical information in many different directions, including investigating how infants represent regularities, learn about different levels of language, and integrate information across situations. These current directions emphasize studying statistical language learning in context: within language, within the infant learner, and within the environment as a whole. PMID:21666883

Conference scene: Select Biosciences Epigenetics Europe 2010.

PubMed

Razvi, Enal S

2011-02-01

The field of epigenetics is now on a geometric rise, driven in a large part by the realization that modifiers of chromatin are key regulators of biological processes in vivo. The three major classes of epigenetic effectors are DNA methylation, histone post-translational modifications (such as acetylation, methylation or phosphorylation) and small noncoding RNAs (most notably microRNAs). In this article, I report from Select Biosciences Epigenetics Europe 2010 industry conference held on 14-15 September 2010 at The Burlington Hotel, Dublin, Ireland. This industry conference was extremely well attended with a global pool of delegates representing the academic research community, biotechnology companies and pharmaceutical companies, as well as the technology/tool developers. This conference represented the current state of the epigenetics community with cancer/oncology as a key driver. In fact, it has been estimated that approximately 45% of epigenetic researchers today identify cancer/oncology as their main area of focus vis-à-vis their epigenetic research efforts.

The TERESA project: from space research to ground tele-echography

NASA Technical Reports Server (NTRS)

Vieyres, Pierre; Poisson, Gerard; Courreges, Fabien; Merigeaux, Olivier; Arbeille, Philippe

2003-01-01

Ultrasound examinations represent one of the major diagnostic modalities of future healthcare. They are currently used to support medical space research but require a high skilled operator for both probe positioning on the patient's skin and image interpretation. TERESA is a tele-echography project that proposes a solution to bring astronauts and remotely located patients on ground quality ultrasound examinations despite the lack of a specialist at the location of the wanted medical act.

Intergenerational Transmission of Abuse of Incarcerated Fathers: A Study of the Measurement of Abuse

ERIC Educational Resources Information Center

Ball, Jeremy D.

2009-01-01

Research on the intergenerational transmission of abuse hypothesis often only examined the "existence" of abuse. The current study utilizes retrospective recalls of incarcerated male defendants (N = 414), using questions formulated from the modified Conflict Tactics Scales. Five logistic regression models are run, representing a different physical…

Effectiveness of Interactive Computer-Based Instruction: A Review of Studies Published between 1995 and 2007

ERIC Educational Resources Information Center

Johnson, Douglas A.; Rubin, Sophie

2011-01-01

Computer-based instruction (CBI) has been growing rapidly as a training tool in organizational settings, but close attention to behavioral factors has often been neglected. CBI represents a promising instructional advancement over current training methods. This review article summarizes 12 years of comparative research in interactive…

Hemispheric Differences in the Activation of Perceptual Information during Sentence Comprehension

ERIC Educational Resources Information Center

Lincoln, Amy E.; Long, Debra L.; Baynes, Kathleen

2007-01-01

Previous research has suggested that perceptual information about objects is activated during sentence comprehension [Zwaan, R. A., Stanfield, R. A., & Yaxley, R. H. (2002). Language comprehenders mentally represent the shapes of objects. "Psychological Science, 13"(2), 168-171]. The goal in the current study was to examine the role of the two…

Gender Differences in Symptoms of Autism Spectrum Disorders in Toddlers

ERIC Educational Resources Information Center

Sipes, Megan; Matson, Johnny L.; Worley, Julie A.; Kozlowski, Alison M.

2011-01-01

Gender differences in symptoms representing the triad of impairments of Autism Spectrum Disorders remain unclear. To date, the majority of research conducted on this topic has utilized samples of older children. Thus, the purpose of the current study was to utilize a sample of toddlers to investigate gender differences in symptom endorsements of…

Attributions, Influences and Outcomes for Underrepresented and Disadvantaged Participants of a Medical Sciences Enrichment Pipeline Program

ERIC Educational Resources Information Center

Pinckney, Charlyene Carol

2014-01-01

The current study was undertaken to examine the effectiveness of the Rowan University-School of Osteopathic Medicine - Summer Pre-Medical Research and Education Program (Summer PREP), a postsecondary medical sciences enrichment pipeline program for under-represented and disadvantaged students. Thirty-four former program participants were surveyed…

Validating Accelerometry and Skinfold Measures in Youth with Down Syndrome

ERIC Educational Resources Information Center

Esposito, Phil Michael

2012-01-01

Current methods for measuring quantity and intensity of physical activity based on accelerometer output have been studied and validated in youth. These methods have been applied to youth with Down syndrome (DS) with no empirical research done to validate these measures. Similarly, individuals with DS have unique body proportions not represented by…

School-Based Obesity Prevention: Research, Challenges, and Recommendations

ERIC Educational Resources Information Center

Budd, Geraldine M.; Volpe, Stella L.

2006-01-01

Childhood overweight is one of the most serious problems currently affecting individual and public health. Schools represent a logical site for prevention because children spend 6-8 hours a day there during most of the year. Although reports of school-based overweight or obesity prevention programs exist, there are no summaries specifying which…

Improving Science Assessments by Situating Them in a Virtual Environment

ERIC Educational Resources Information Center

Ketelhut, Diane Jass; Nelson, Brian; Schifter, Catherine; Kim, Younsu

2013-01-01

Current science assessments typically present a series of isolated fact-based questions, poorly representing the complexity of how real-world science is constructed. The National Research Council asserts that this needs to change to reflect a more authentic model of science practice. We strongly concur and suggest that good science assessments…

Where Are the Faculty Leaders?: Strategies and Advice for Reversing Current Trends

ERIC Educational Resources Information Center

Kezar, Adrianna; Lester, Jaime; Carducci, Rozana; Gallant, Tricia Bertram; McGavin, Melissa Contreras

2007-01-01

Faculty members who work directly to advance the institutional mission of teaching, learning, and at some institutions, research, represent the core human resource of higher education. They are the stewards of campus leadership and decision making. While the faculty role has changed over time, leadership has remained critical to innovation in…

Lifestyle Orientations in Late Adolescence and Patterns of Substance Abuse.

ERIC Educational Resources Information Center

Johnston, Lloyd D.; And Others

This paper presents selected research findings from Monitoring the Future, an annual series of national surveys focusing on lifestyles and drug use among representative samples of American high school seniors that has been conducted every year since 1975. The presentation focuses on two issues: aspects of lifestyle currently associated with drug…

Youth in Northern Ireland: Introduction to the Special Issue.

ERIC Educational Resources Information Center

Percy, Andrew

2000-01-01

Introduces a collection of articles that represent some of the research and policy analysis of key issues affecting the lives of young people currently living in Northern Ireland, which is in the midst of an unparalleled political and social transformation. The articles focus on crime, drug use, criminal justice, families, divorce, and youth…

Communicating Charisma in Instructional Settings: Indicators and Effects of Charismatic Teaching

ERIC Educational Resources Information Center

Bolkan, San; Goodboy, Alan K.

2014-01-01

Within their classrooms, instructors may engage in a variety of behaviors including those perceived to be charismatic. Though researchers have uncovered instructor behaviors that have been postulated to theoretically represent charisma in the classroom, to date no quantitative data have been presented to support these claims. The current study…

Sentence Processing: Psycholinguistic Studies Presented to Merrill Garrett.

ERIC Educational Resources Information Center

Cooper, William E., Ed.; Walker, Edward C. T., Ed.

The chapters in this volume represent a type of current psycholinguistic research that focuses both on the nature of human information processing and the coding of linguistic structure. The chapters and authors are as follows: (1) "The Wherefores and Therefores of the Competence-Performance Distinction," by V. Valian; (2) "Levels of Processing and…

How Teachers Teach: Mapping the Terrain of Practice

ERIC Educational Resources Information Center

Sykes, Gary; Wilson, Suzanne

2015-01-01

This paper--conceived as a framework for competencies in teaching--represents an interpretive synthesis by the authors of main and contemporary currents in the research on teaching and learning. The framework resulting from this review parses teaching into two main domains--instruction and role responsibilities--within each of which a set of broad…

School Choice: The Perceptions of Rural Public School Educators

ERIC Educational Resources Information Center

Brabham, Jessica Marlene

2010-01-01

This study identified the feelings and beliefs that rural educators possess about the options of school choice, via vouchers, as currently discussed by federal and state governments. The sample of this study consisted of 250 educators, representing 10 different schools, who completed a school choice survey developed by the researcher. A comparison…

1984-2008. Predictions for Higher Education. From the 25th Anniversary Colloquium. [Proceedings].

ERIC Educational Resources Information Center

Hardee, Melvene Draheim, Ed.

Predictions on higher education for 1984-2009 are presented in the proceedings of a colloquium of the Institute for Studies in Higher Education of Florida State University. Presentations were made at the colloquium by 10 graduates of the university whose current positions represent administration-management, instruction, research, and student…

Use of Specialty Mental Health Services by Asian Americans with Psychiatric Disorders

ERIC Educational Resources Information Center

Le Meyer, Oanh; Zane, Nolan; Cho, Young Il; Takeuchi, David T.

2009-01-01

Research suggests that Asian Americans underutilize mental health services but an understanding of the multiple factors involved in utilization has not been examined in a nationally representative sample. The current study analyzed data from the National Latino and Asian American Study (NLAAS) and examined 368 individuals with disorders to…

Identifying Gender-Specific Developmental Trajectories of Nonviolent and Violent Delinquency from Adolescence to Young Adulthood

ERIC Educational Resources Information Center

Zheng, Yao; Cleveland, H. Harrington

2013-01-01

Most research examining gender differences in developmental trajectories of antisocial behavior does not consider subtypes of antisocial behavior and is difficult to generalize due to small non-representative samples. The current study investigated gender difference in developmental trajectories from adolescence to young adulthood while addressing…

WET DEPOSITION AND AIR-WATER GAS EXCHANGE OF CURRENTLY USED PESTICIDES TO A SUB-ESTUARY OF THE CHESAPEAKE BAY. (R825245)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

If Your Technology has an Application for the Natural Gas Industry, OTD is Interested in Learning About It

NASA Astrophysics Data System (ADS)

Droessler, M. S.

2017-12-01

It's as easy as clicking on the "Submit Your Idea" tab on our website and sending us a short description of your technology. Operations Technology Development (OTD) funds 30 to 40 new projects each year. We have a research budget of $10 million annually and it doesn't always get spent. So who are we and what are we interested in? OTD is a membership company made up of 24 members representing the largest natural gas distribution utilities in North America. We represent 60% of the households currently served by natural gas. With OTD, natural gas utilities work together to identify their needs, leverage their funds, and prioritize and solve common problems. Our research ranges from addressing environmental issues, pipeline and worker safety, risk reduction, pipeline inspection, and reducing the costs of daily operations. Some specific examples include locating buried nonmetallic pipe and improving ways to pinpoint and quantify the release of methane. Analyzing "big data" sets and dealing with cyber security have our IT departments up at night so these are some of the newer topics of interest. Please see if our needs match the research you are passionate about by glancing through our current Research Project Summaries at otd-co.org. So what's your great idea? We want to hear about it.

BioAge: Toward A Multi-Determined, Mechanistic Account of Cognitive Aging

PubMed Central

DeCarlo, Correne A.; Tuokko, Holly A.; Williams, Dorothy; Dixon, Roger A.; MacDonald, Stuart W.S.

2014-01-01

The search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline. PMID:25278166

BioAge: toward a multi-determined, mechanistic account of cognitive aging.

PubMed

DeCarlo, Correne A; Tuokko, Holly A; Williams, Dorothy; Dixon, Roger A; MacDonald, Stuart W S

2014-11-01

The search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline. Copyright © 2014 Elsevier B.V. All rights reserved.

Using Health Care Utilization and Publication Patterns to Characterize the Research Portfolio and to Plan Future Research Investments.

PubMed

Katz, Luba; Fink, Rebecca V; Bozeman, Samuel R; McNeil, Barbara J

2014-01-01

Government funders of biomedical research are under increasing pressure to demonstrate societal benefits of their investments. A number of published studies attempted to correlate research funding levels with the societal burden for various diseases, with mixed results. We examined whether research funded by the Department of Veterans Affairs (VA) is well aligned with current and projected veterans' health needs. The organizational structure of the VA makes it a particularly suitable setting for examining these questions. We used the publication patterns and dollar expenditures of VA-funded researchers to characterize the VA research portfolio by disease. We used health care utilization data from the VA for the same diseases to define veterans' health needs. We then measured the level of correlation between the two and identified disease groups that were under- or over-represented in the research portfolio relative to disease expenditures. Finally, we used historic health care utilization trends combined with demographic projections to identify diseases and conditions that are increasing in costs and/or patient volume and consequently represent potential targets for future research investments. We found a significant correlation between research volume/expenditures and health utilization. Some disease groups were slightly under- or over-represented, but these deviations were relatively small. Diseases and conditions with the increasing utilization trend at the VA included hypertension, hypercholesterolemia, diabetes, hearing loss, sleeping disorders, complications of pregnancy, and several mental disorders. Research investments at the VA are well aligned with veteran health needs. The VA can continue to meet these needs by supporting research on the diseases and conditions with a growing number of patients, costs of care, or both. Our approach can be used by other funders of disease research to characterize their portfolios and to plan research investments.

Poly-Tobacco Use among High School Students

PubMed Central

Kowitt, Sarah D.; Patel, Tanha; Ranney, Leah M.; Huang, Li-Ling; Sutfin, Erin L.; Goldstein, Adam O.

2015-01-01

Although cigarette use by adolescents is declining, emerging tobacco products are becoming increasingly popular and youth may use more than one type of tobacco product. The purposes of this study were: (1) to assess patterns of poly-tobacco use among a representative sample of high school students and (2) to determine how beliefs correlate with poly-tobacco use. Data came from the 2013 North Carolina Youth Tobacco Survey (n = 4092). SAS logistic regression survey procedures were used to account for the complex survey design and sampling weights. Among all high school students in NC in 2013, 29.7% reported current any tobacco use, with 19.1% reporting current poly-tobacco use, and 10.6% reporting current use of only one product. Among poly-tobacco users, 59.3% reported that one of the products they currently used was cigarettes. Positive tobacco product beliefs were found to be significantly associated with poly-tobacco use. Communication campaigns, policy efforts, and future research are needed for prevention, regulation, and control of poly-tobacco use among adolescents, which represents a significant public health problem. PMID:26580636

Medical research in emergency research in the European Union member states: tensions between theory and practice.

PubMed

Kompanje, Erwin J O; Maas, Andrew I R; Menon, David K; Kesecioglu, Jozef

2014-04-01

In almost all of the European Union member states, prior consent by a legal representative is used as a substitute for informed patient consent for non-urgent medical research. Deferred (patient and/or proxy) consent is accepted as a substitute in acute emergency research in approximately half of the member states. In 12 European Union member states emergency research is not mentioned in national law. Medical research in the European Union is covered by the Clinical Trial Directive 2001/20/EC. A proposal for a regulation by the European Commission is currently being examined by the European Parliament and the Council and will replace Directive 2001/20/EC. Deferred patient and/or proxy consent is allowed in the proposed regulation, but does not fit completely in the practice of emergency research. For example, deferred consent is only possible when legal representatives are not available. This criterion will delay inclusion of patients in acute life-threatening conditions in short time frames. As the regulation shall be binding in its entirety in all member states, emergency research in acute situations is still not possible as it should be.

Scientific progress - wireless phones and brain cancer: current state of the science.

PubMed

Carlo, G L; Jenrow, R S

2000-07-11

The current science is not definitive about health risks from wireless phones; however, the legitimate questions about safety that have arisen from recent studies make claims of absolute safety no longer supportable. The objective of this paper is to outline for primary care providers the results of the most current research on the possible impact of wireless phone use on human health. Presented are study results from Wireless Technology Research (WTR) program, the 7-year, $27 million effort funded by the wireless industry in the United States, that represents the world's most comprehensive research effort addressing this issue to date. Science-based recommendations for consumer interventions and future research are presented. Original studies performed under the WTR program as well as other relevant research from around the world. This article presents a synopsis of the peer-reviewed in vitro and in vivo laboratory research, and the peer-reviewed epidemiology studies supported by the WTR, as well as a summary of other relevant work. Only peer-reviewed scientific studies are presented, primarily WTR-sponsored research. In addition, results of the WTR literature surveillance program, which identified other relevant toxicology and epidemiology studies on an ongoing basis, are presented. These studies are presented in the context of their usefulness in providing intervention recommendations for consumers. Following a qualitative synthesis of specific relevant non-WTR research and a critical assessment of the WTR results, the following represents the current state of scientific understanding relevant to the public health impact of wireless phones: laboratory studies appear to have confirmed that radio frequency radiation from wireless phone antennas is insufficient to cause DNA breakage; however, this same radiation appears to cause genetic damage in human blood as measured through the formation of micronuclei. An increase in the rate of brain cancer mortality among hand-held cellular phone users as compared to car phone users, though not statistically significant, was observed in the WTR cohort study. A statistically significant increase in the risk of neuro-epithelial brain tumors was observed among cellular phone users in another case-control study. As new data emerge, our understanding of this complex problem will improve; however, at present there is a critical need for ongoing and open evaluation of the public health impact of new science, and communication of this science and derivative intervention options to those who are potentially affected.

Federal Arctic Research Information Workshop: Workshop proceedings

NASA Astrophysics Data System (ADS)

Geiselman, Joy; Mitchell, Kathryn L.

1991-07-01

The Federal Arctic Research Information Workshop was organized on behalf of the Inter-Agency Arctic Research Policy Committee (IARPC) in order to facilitate the exchange of information on Federal research to fulfill the intent of the Arctic Research and Policy Act of 1984. The workshop was held on 19-21 Mar. 1991, and representatives from Federal agencies were invited to report on recent accomplishments of research and related activities and to exchange information on current and future projects and programs. The various Federal agencies included the Departments of Agriculture, Commerce, Defense, Energy, Health and Human Services, Interior, and Transportation. The Environmental Protection Agency, NASA, National Science Foundation, and the Smithsonian Institution also presented papers.

Expanding Cancer Prevention Education to National and International Audiences: The National Cancer Institute’s Principles and Practice of Cancer Prevention and Control Annual Summer Course

PubMed Central

Faupel-Badger, Jessica M.; van Bemmel, Dana M.; Wiest, Jonathan S.; Nelson, David E.

2012-01-01

The Summer Curriculum in Cancer Prevention has been sponsored by the National Cancer Institute’s Cancer Prevention Fellowship Program for over two decades. This curriculum includes a four-week course entitled “Principles and Practice of Cancer Prevention and Control.” The ultimate goal of this course is to present the most current cancer prevention research to a diverse workforce of researchers and practitioners eager to address the current challenges in this field. The course covers the current status of cancer prevention research and practice, ranging from epidemiology and clinical practice, and from basic to behavioral science research. It is comprised of lectures grouped into nine modules representing broad and specific topics relevant to cancer prevention. Course participants come from a broad cross-section of career stages, professions, and research interests, and are from across the United States and other countries. Over time and in response to feedback from participants, the course has developed to meet the needs and expectations of this diverse audience, and may serve as a model for those interested in cancer prevention education and training in other countries. PMID:21785976

A New Trans-Disciplinary Approach to Regional Integrated Assessment of Climate Impact and Adaptation in Agricultural Systems (Invited)

NASA Astrophysics Data System (ADS)

Antle, J. M.; Valdivia, R. O.; Jones, J.; Rosenzweig, C.; Ruane, A. C.

2013-12-01

This presentation provides an overview of the new methods developed by researchers in the Agricultural Model Inter-comparison and Improvement Project (AgMIP) for regional climate impact assessment and analysis of adaptation in agricultural systems. This approach represents a departure from approaches in the literature in several dimensions. First, the approach is based on the analysis of agricultural systems (not individual crops) and is inherently trans-disciplinary: it is based on a deep collaboration among a team of climate scientists, agricultural scientists and economists to design and implement regional integrated assessments of agricultural systems. Second, in contrast to previous approaches that have imposed future climate on models based on current socio-economic conditions, this approach combines bio-physical and economic models with a new type of pathway analysis (Representative Agricultural Pathways) to parameterize models consistent with a plausible future world in which climate change would be occurring. Third, adaptation packages for the agricultural systems in a region are designed by the research team with a level of detail that is useful to decision makers, such as research administrators and donors, who are making agricultural R&D investment decisions. The approach is illustrated with examples from AgMIP's projects currently being carried out in Africa and South Asia.

National Toxicology Program: Review of current DHHS, DOE, and EPA research related to toxicology, Fiscal Year 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-06-01

The report represents responses by agencies of DHHS, and by DOE and EPA, to requests by the Director of NTP for information on agency programs in basic toxicology research, toxicology testing, and toxicology methods development. Information on dollar and manpower support for agency activities in basic toxicology research, toxicology testing, and toxicology methods development, by DHHS, DOE and EPA, is summarized on pages 4 to 10. All agencies were requested to provide summary information on their programs related to toxicology methods development, whether essential or peripheral to their missions. The information provided in response to the request is summarized inmore » tables on pages 48 to 81. Information was provided on chemical compounds currently being studied for their toxicological properties in intramural laboratories, or on contracts, or through grants.« less

[Assessment of innovations in clinical research: strengths and potentials for improvement of research in Germany].

PubMed

Vollmar, Horst Christian; Georgieff, Peter; Bührlen, Bernhard

2010-01-01

Clinical research is a central link in the development chain of new treatment methods; scientifically, it belongs between basic science and health services research. It spans from the first application of a new substance or device in humans to the main proofs of its efficacy and safety. Economically speaking, it absorbs almost half of the total expenditures for the research and development of a new drug and represents a significant factor in the labour market for researchers and study personnel. Also, through participation in clinical trials, patients gain early access to new treatment methods, while on the other hand they are placed at higher risk for undesired side effects. Politics have taken significant steps to strengthen clinical research, but the pharmaceutical industry continues to complain about competitive disadvantages. Despite internationally recognised and, to a large extent, legally codified guidelines there are still significant national differences in implementation. In addition, traditional practices in clinical research are challenged by novel, mainly biotechnological therapeutic methods for which our current knowledge base is rather limited and which therefore entail a higher risk for patients or trial participants. The following paper summarises a report for the Office of Technology Assessment at the German Federal Parliament (TAB). Based on current regulations, scientific literature and expert interviews, current challenges and solution strategies for clinical research will be analysed in terms of an international comparison.

Network Coding in Relay-based Device-to-Device Communications

PubMed Central

Huang, Jun; Gharavi, Hamid; Yan, Huifang; Xing, Cong-cong

2018-01-01

Device-to-Device (D2D) communications has been realized as an effective means to improve network throughput, reduce transmission latency, and extend cellular coverage in 5G systems. Network coding is a well-established technique known for its capability to reduce the number of retransmissions. In this article, we review state-of-the-art network coding in relay-based D2D communications, in terms of application scenarios and network coding techniques. We then apply two representative network coding techniques to dual-hop D2D communications and present an efficient relay node selecting mechanism as a case study. We also outline potential future research directions, according to the current research challenges. Our intention is to provide researchers and practitioners with a comprehensive overview of the current research status in this area and hope that this article may motivate more researchers to participate in developing network coding techniques for different relay-based D2D communications scenarios. PMID:29503504

Impact of forced displacement during World War II on the present-day mental health of the elderly: a population-based study.

PubMed

Kuwert, Philipp; Brähler, Elmar; Glaesmer, Heide; Freyberger, Harald Jürgen; Decker, Oliver

2009-08-01

The effects of traumatization among the elderly is a neglected topic in research and clinical settings. Forced displacement of civilians is one of the main traumatic features of modern armed conflict. Roughly 12 million German people were displaced in World War II (WWII) and to our knowledge there has been no representative study investigating the mental health outcomes of such trauma in the elderly population. The survey assessed whether current depression, anxiety, resilience and life satisfaction were significantly associated with forced displacement in WWII. A nationwide representative face-to-face household survey was conducted in Germany. A representative sample of the German population aged 61 years or older (N = 1513 participants, N = 239 displaced in WWII) was approached using 258 sample points. Measurements included depressive symptoms (PHQ-2), anxiety (GAD-7), resilience (RS-11), general and domain-specific life satisfaction (FLZ(M)) and sociodemographic variables. Forced displacement in WWII is significantly associated with higher levels of anxiety and lower levels of resilience and life satisfaction 60 years later. In regression analyses, forced displacement in WWII significantly predicted current anxiety (beta 0.07; p < 0.01), life satisfaction (beta -0.06; p < 0.05) and resilience (beta -0.07; p < 0.01). To our knowledge this is the first nationwide representative survey to examine the late-life effects of forced displacement, particularly of persons displaced during WWII in Germany. Further research is needed to identify mediating variables and to evaluate psychotherapeutic interventions in elderly trauma survivors.

Community participatory research with deaf sign language users to identify health inequities.

PubMed

Barnett, Steven; Klein, Jonathan D; Pollard, Robert Q; Samar, Vincent; Schlehofer, Deirdre; Starr, Matthew; Sutter, Erika; Yang, Hongmei; Pearson, Thomas A

2011-12-01

Deaf people who use American Sign Language (ASL) are medically underserved and often excluded from health research and surveillance. We used a community participatory approach to develop and administer an ASL-accessible health survey. We identified deaf community strengths (e.g., a low prevalence of current smokers) and 3 glaring health inequities: obesity, partner violence, and suicide. This collaborative work represents the first time a deaf community has used its own data to identify health priorities.

Community Participatory Research With Deaf Sign Language Users to Identify Health Inequities

PubMed Central

Barnett, Steven; Klein, Jonathan D.; Pollard, Robert Q.; Samar, Vincent; Schlehofer, Deirdre; Starr, Matthew; Sutter, Erika; Yang, Hongmei

2011-01-01

Deaf people who use American Sign Language (ASL) are medically underserved and often excluded from health research and surveillance. We used a community participatory approach to develop and administer an ASL-accessible health survey. We identified deaf community strengths (e.g., a low prevalence of current smokers) and 3 glaring health inequities: obesity, partner violence, and suicide. This collaborative work represents the first time a deaf community has used its own data to identify health priorities. PMID:22021296

Market Research Survey of Commercial Off-The-Shelf (COTS) Portable MS Systems for IAEA Safeguards Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, Garret L.; Hager, George J.; Barinaga, Charles J.

2013-02-01

This report summarizes the results for the market research survey of mass spectrometers that are deemed pertinent to International Atomic Energy Agency (IAEA) needs and strategic objectives. The focus of the report is on MS instruments that represent currently available (or soon to be) commercial off-the shelf (COTS) technology and weigh less than 400 pounds. A compilation of all available MS instruments (36 COTS and 2 R&D) is presented, along with pertinent information regarding each instrument.

Bioenvironmental aspects of europium and rhodium: a selected bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fore, C.S.; Carrier, R.F.; Talmage, S.S.

This bibliography of 428 abstracted references represents a summary of the domestic and foreign literature relevant to the biological and environmental aspects of europium and rhodium. The collected data are organized by current NAEG interests - research highlighting inventory and distribution of the radionulcides, ecological studies covering terrestrial and aquatic systems, and biological studies in both man and animals. Studies that focus directly on research conducted at specific sites (e.g., the Nevada Test Site) are emphasized throughout the bibliography. (ACR)

The Importance of Human Immunodeficiency Virus Research for Transgender and Gender-Nonbinary Individuals.

PubMed

Gianella, Sara; Sonya Haw, J; Blumenthal, Jill; Sullivan, Brooke; Smith, Davey

2018-04-17

Transgender and gender-nonbinary (trans/GNB) individuals are disproportionally affected by human immunodeficiency virus (HIV), yet they are not adequately represented in HIV research and often underserved in clinical care. By building on community strengths and addressing structural, psychological and biological challenges, we can improve the engagement of trans/GNB people in research and ultimately improve prevention, testing, and care for this population. Here, we review the current state of the science related to HIV for trans/GNB people and discuss next steps to expand research that aims to improve the lives and well-being of trans/GNB persons.

USE OF SPACE TECHNOLOGY IN FEDERALLY FUNDED LAND PROCESSES RESEARCH IN THE UNITED STATES.

USGS Publications Warehouse

Thorley, G.A.; McArdle, R.

1986-01-01

A review of the use of space technology in federally funded earth science research in the US was carried out in 1985 by the President's Office of Science and Technology Policy. Five departments and three independent agencies, representing the primary earth science research agencies in the Federal government, participated in the review. The review by the subcommittee indicated that, while there is considerable overlap in the legislated missions of the earth science agencies, most of the space-related land processes research is complementary. Summaries are provided of the current and projected uses of space technology in land processes activities within the eight Federal organizations.

Black Hills State University Research and Scholarly Work Symposium Proceedings (Spearfish, South Dakota, May 2, 1995).

ERIC Educational Resources Information Center

Anagnopoulos, Cheryl, Ed.; Ochse, Roger, Ed.; Wolff, Roger, Ed.

This proceedings contains papers from a symposium conducted to promote the professional sharing of scholarly accomplishments of Black Hills State University (South Dakota) faculty and students. The symposium also provided a forum for discussion of current issues related to the presentations. The papers, representing a variety of disciplines, are…

Building Comprehensive Career Guidance Programs for Secondary Schools: A Handbook of Programs, Practices, and Models. Research and Development Series No. 147.

ERIC Educational Resources Information Center

Campbell, Robert E.; And Others

This handbook presents management techniques, program ideas, and student activities for building comprehensive secondary career guidance programs. Part 1 (chapter 1) traces the history of guidance to set the stage for the current emphasis on comprehensive programs, summarizes four representative models for designing comprehensive programs, and…

Explaining the Under-Representation of Women in Leadership Positions of Sport Organizations: A Symbolic Interactionist Perspective

ERIC Educational Resources Information Center

Sartore, Melanie L.; Cunningham, George B.

2007-01-01

Research suggests that females are vastly under-represented in the upper echelons of sport organizations. As such, the purpose of the current article was to apply a symbolic interactionist perspective to the lacking presence of women in leadership positions of sport organizations. The model proposes that gender-role meanings and stereotypes…

Black Hills State University Research and Scholarly Work Symposium Proceedings (Spearfish, South Dakota, April 11, 1994).

ERIC Educational Resources Information Center

Anagnopoulos, Cheryl L., Ed.; Ochse, Roger, Ed.; Wolff, Roger, Ed.

This proceedings contains papers from a symposium conducted to promote the professional sharing of scholarly accomplishments of Black Hills State University faculty and students. The symposium also provided a forum for discussion of current issues related to the presentations. The papers, representing a variety of disciplines, are as follows:…

The Relationship between English Language Learner Status and Music Ensemble Participation

ERIC Educational Resources Information Center

Lorah, Julie A.; Sanders, Elizabeth A.; Morrison, Steven J.

2014-01-01

Authors of previous research have reported that U.S. English language learner (ELL) students participate in school-sponsored music ensembles (band, orchestra, and choir) at a lower rate than their native-English-speaking peers (non-ELLs). The current study examined this phenomenon using a nationally representative sample of U.S. 10th graders (14-…

An Illustration of the Use of Markov Decision Processes to Represent Student Growth (Learning). Research Report. ETS RR-07-40

ERIC Educational Resources Information Center

Almond, Russell G.

2007-01-01

Over the course of instruction, instructors generally collect a great deal of information about each student. Integrating that information intelligently requires models for how a student's proficiency changes over time. Armed with such models, instructors can "filter" the data--more accurately estimate the student's current proficiency…

Schooling Effects on Intelligence Development: Evidence Based on National Samples from Urban and Rural China

ERIC Educational Resources Information Center

Wang, Tengfei; Ren, Xuezhu; Schweizer, Karl; Xu, Fen

2016-01-01

The current research investigated the variability of school effects on intelligence development in considering two economically and socially distinct groups of children. The data came from a nationally representative sample of primary school children from urban and rural areas of China. Two standardised reasoning tests were used to assess fluid…

Infants Use Different Mechanisms to Make Small and Large Number Ordinal Judgments

ERIC Educational Resources Information Center

vanMarle, Kristy

2013-01-01

Previous research has shown indirectly that infants may use two different mechanisms-an object tracking system and an analog magnitude mechanism--to represent small (less than 4) and large (greater than or equal to 4) numbers of objects, respectively. The current study directly tested this hypothesis in an ordinal choice task by presenting 10- to…

Biodiversity informatics: challenges and opportunities for applying biodiversity information to management and conservation

Treesearch

James S. Kagan

2006-01-01

Researchers, land managers, and the public currently often are unable to obtain useful biodiversity information because the subject represents such a large component of biology and ecology, and systems to compile and organize this information do not exist. Information on vascular plant taxonomy, as addressed by the Global Biodiversity Information Facility and key...

The Effect of Firm Strategy and Corporate Performance on Software Market Growth in Emerging Regions

ERIC Educational Resources Information Center

Mertz, Sharon A.

2013-01-01

The purpose of this research is to evaluate the impact of firm strategies and corporate performance on enterprise software market growth in emerging regions. The emerging regions of Asia Pacific, Eastern Europe, the Middle East and Africa, and Latin America, currently represent smaller overall markets for software vendors, but exhibit high growth…

The Deficit Profiles of Chinese Children with Reading Difficulties: A Meta-Analysis

ERIC Educational Resources Information Center

Peng, Peng; Wang, Cuicui; Tao, Sha; Sun, Congying

2017-01-01

The current meta-analysis synthesized findings from profiling research on Chinese children with reading difficulties (RD). We reviewed a total of 81 studies published between 1964 and May 2015, representing a total of 9735 Chinese children. There are 982 effect sizes for the comparison between children with RD and age-matched typically developing…

Avoiding the "Brick Wall of Awkward": Perspectives of Youth with Autism Spectrum Disorder on Social-Focused Intervention Practices

ERIC Educational Resources Information Center

Bottema-Beutel, Kristen; Mullins, Teagan S.; Harvey, Michelle N.; Gustafson, Jenny R.; Carter, Erik W.

2016-01-01

Many youth with autism spectrum disorder participate in school-based, peer-mediated intervention programs designed to improve their social experiences. However, there is little research discerning how these youth view intervention practices currently represented in the literature, information which could improve the social validity of intervention…

Portrayals of Bullying in Young Adult Literature: Considerations for Schools

ERIC Educational Resources Information Center

Hughes, Janette; Laffier, Jennifer Lynn

2016-01-01

In this article, the authors examine how bullying is portrayed in three recent young adult novels, focusing specifically on whether the information about bullying is accurate, biased, or represents old myths in comparison to current research. The authors conduct a systematic analysis of the following four themes: (1) What is bullying?; (2) Who are…

An Examination of the Interrelationships between Self-Esteem, Others' Expectations, Family Support, Learning Approaches and Academic Achievement

ERIC Educational Resources Information Center

Roman, Sergio; Cuestas, Pedro J.; Fenollar, Pedro

2008-01-01

The current research represents an initial step into the analysis of the effect of self-esteem, others' (peers and teachers) expectations and family support on academic achievement through learning approaches (deep processing, surface processing and effort). Data were gathered from 553 university students from different faculties of a Spanish…

The Role of Traumatic Event History in Non-Medical Use of Prescription Drugs among a Nationally Representative Sample of US Adolescents

ERIC Educational Resources Information Center

McCauley, Jenna L.; Danielson, Carla Kmett; Amstadter, Ananda B.; Ruggiero, Kenneth J.; Resnick, Heidi S.; Hanson, Rochelle F.; Smith, Daniel W.; Saunders, Benjamin E.; Kilpatrick, Dean G.

2010-01-01

Background: Building on previous research with adolescents that examined demographic variables and other forms of substance abuse in relation to non-medical use of prescription drugs (NMUPD), the current study examined potentially traumatic events, depression, posttraumatic stress disorder (PTSD), other substance use, and delinquent behavior as…

Proceedings of the sixth California oak symposium: today's challenges, tomorrow's opportunities

Treesearch

Adina Merenlender; Douglas McCreary; Kathryn L. Purcell

2008-01-01

The Sixth Oak Symposium provided a forum for current research and outstanding case studies on oak woodland science and sustainability in California. This symposium was the latest in a series of conferences on this subject held every 5 years since 1979. The proceedings from this conference series represent the most comprehensive source of scientific and management...

Teaching Healthy Eating to Elementary School Students: A Scoping Review of Nutrition Education Resources

ERIC Educational Resources Information Center

Peralta, Louisa R.; Dudley, Dean A.; Cotton, Wayne G.

2016-01-01

Background: School-based programs represent an ideal setting to enhance healthy eating, as most children attend school regularly and consume at least one meal and a number of snacks at school each day. However, current research reports that elementary school teachers often display low levels of nutritional knowledge, self-efficacy, and skills to…

Information Technologies as Health Management Tools: Urban Elders' Interest and Ability in Using the Internet

ERIC Educational Resources Information Center

Cresci, M. Kay; Novak, Julie M.

2012-01-01

Older adults represent an increasing percentage of both the whole U.S. population and persons living with one or more chronic health conditions. However, extant research has largely overlooked older adults when examining current Internet users and the potential for the Internet as a health management resource. In this study, the researchers…

Combining the Best of Two Worlds: A Conceptual Proposal for Evidence-Informed School Improvement

ERIC Educational Resources Information Center

Brown, Chris; Schildkamp, Kim; Hubers, Mireille D.

2017-01-01

Background: Data-based decision-making (DBDM) and research-informed teaching practice (RITP) are key to teacher and school improvement. Currently, however, DBDM and RITP represent two distinct approaches to developing evidence-informed practice (EIP) and do not correspond to the all-encompassing notion of EIP envisaged by many academics and…

Targeting the Cerebellum by Noninvasive Neurostimulation: a Review.

PubMed

van Dun, Kim; Bodranghien, Florian; Manto, Mario; Mariën, Peter

2017-06-01

Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with the cerebral regions subserving motor, associative, and affective functions, the cerebello-thalamo-cortical pathways are an interesting target for these new techniques. Targeting the cerebellum represents a novel way to modulate the excitability of remote cortical regions and their functions. This review brings together the studies that have applied cerebellar stimulation, magnetic and electric, and presents an overview of the current knowledge and unsolved issues. Some recommendations for future research are implemented as well.

Transdisciplinary translational behavioral (TDTB) research: opportunities, barriers, and innovations.

PubMed

Czajkowski, Susan M; Lynch, Minda R; Hall, Kara L; Stipelman, Brooke A; Haverkos, Lynne; Perl, Harold; Scott, Marcia S; Shirley, Mariela C

2016-03-01

The translation of basic behavioral science discoveries into practical strategies represents a promising approach to developing more effective preventive interventions to improve health. Since translational research inevitably involves making use of diverse perspectives from multiple disciplines, it is best conducted as a transdisciplinary enterprise. In this paper, we discuss current strategies used by NIH to support transdisciplinary translational behavioral (TDTB) research, summarize successful efforts, and highlight challenges encountered in conducting such work (ranging from conceptual to organizational to methodological). Using examples from NIH-funded projects we illustrate the potential benefits of, and barriers to, pursuing this type of research and discuss next steps and potential future directions for NIH-supported TDTB research.

Intermediate-energy nuclear chemistry workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, G.W.; Giesler, G.C.; Liu, L.C.

1981-05-01

This report contains the proceedings of the LAMPF Intermediate-Energy Nuclear Chemistry Workshop held in Los Alamos, New Mexico, June 23-27, 1980. The first two days of the Workshop were devoted to invited review talks highlighting current experimental and theoretical research activities in intermediate-energy nuclear chemistry and physics. Working panels representing major topic areas carried out indepth appraisals of present research and formulated recommendations for future research directions. The major topic areas were Pion-Nucleus Reactions, Nucleon-Nucleus Reactions and Nuclei Far from Stability, Mesonic Atoms, Exotic Interactions, New Theoretical Approaches, and New Experimental Techniques and New Nuclear Chemistry Facilities.

Conceptual planning for Space Station life sciences human research project

NASA Technical Reports Server (NTRS)

Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.

1986-01-01

The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.

Promoting innovative business in the fishery sector in West Java, Indonesia

NASA Astrophysics Data System (ADS)

Nurhayati, A.; Aisah, I.; Supriatna, A. K.

2018-04-01

West Java represents an important fisheries production center in Indonesia, owing to the abundant capture and aquaculture resources. However, the intrinsic characteristics of fish products such as perishable, voluminous, and seasonal currently prevent fisheries from having brought significant economic contribution to the province. In line with it, this research was aimed to analyze and identify leverage factors that will lead to fishery-based innovative business in West Java. Data used in this research were primary and secondary ones, which were collected through surveys involving 30 respondents representing fish processors and the same number representing consumers. A Focus Group Discussion (FGD) was also carried out to verify the collected data. Analytical tools adopted in this research were fishery triangle product model. Based on the analyses, it was found factors influencing the success of a fishery innovative business in West Java, Indonesia were consecutively: the existence of derivative products, product processing innovativeness, product price competitiveness, market place, and promotion. Based on the fishery trianggle product model, it was found that fish onboard handling, post-harvest handling, and procesing was in the development stage and therefore these production nodes need a particularly high attention.

Representing operations procedures using temporal dependency networks

NASA Technical Reports Server (NTRS)

Fayyad, Kristina E.; Cooper, Lynne P.

1993-01-01

DSN Link Monitor & Control (LMC) operations consist primarily of executing procedures to configure, calibrate, test, and operate a communications link between an interplanetary spacecraft and its mission control center. Currently the LMC operators are responsible for integrating procedures into an end-to-end series of steps. The research presented in this paper is investigating new ways of specifying operations procedures that incorporate the insight of operations, engineering, and science personnel to improve mission operations. The paper describes the rationale for using Temporal Dependency Networks (TDN's) to represent the procedures, a description of how the data is acquired, and the knowledge engineering effort required to represent operations procedures. Results of operational tests of this concept, as implemented in the LMC Operator Assistant Prototype (LMCOA), are also presented.

IEA Wind Task 26. Wind Technology, Cost, and Performance Trends in Denmark, Germany, Ireland, Norway, the European Union, and the United States: 2007–2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vitina, Aisma; Lüers, Silke; Wallasch, Anna-Kathrin

The International Energy Agency Implementing Agreement for cooperation in Research, Development, and Deployment of Wind Energy Systems (IEA Wind) Task 26—The Cost of Wind Energy represents an international collaboration dedicated to exploring past, present and future cost of wind energy. This report provides an overview of recent trends in wind plant technology, cost, and performance in those countries that are currently represented by participating organizations in IEA Wind Task 26: Denmark, Germany, Ireland, Norway, and the United States as well as the European Union.

NASA GSFC Strategic Nanotechnology Interests: Symposium on High-Rate Nanoscale Printing for Devices and Structures

NASA Technical Reports Server (NTRS)

Ericsson, Aprille J.

2014-01-01

The seminars invitees include representatives from industry, nonprofit research facility and universities. The presentation provides an overview of the NASAGSFC locations, technical capabilities and applied nanotechnology interests. Initially presented are advances by the broader technological communities on current miniaturized multiscale advanced manufacturing and 3D printing products on the micro and macro scale. Briefly assessed is the potential of moving toward the nanoscale for possible space flight applications and challenges. Lastly, highlighted are GSFCs current successes in nano-technology developments and targeted future applications.

The new Andean Regional Office of Astronomy for Development

NASA Astrophysics Data System (ADS)

Char, Farid; Forero-Romero, Jaime

2016-10-01

The Andean Regional Office of Astronomy for Development (ROAD) is a new effort in South America to serve several goals in astronomical development. The six countries in the Andean ROAD (Bolivia, Colombia, Chile, Ecuador, Peru and Venezuela) represent a common language block in the region. They work together to develop strategies to strengthen the professional research, education and popularization of astronomy. Our current Working Structure comprises a ROAD Coordinator and one Coordinators in each Task Force. Here we describe the main points of the ROAD's current action plan.

The relation between finger gnosis and mathematical ability: why redeployment of neural circuits best explains the finding

PubMed Central

Penner-Wilger, Marcie; Anderson, Michael L.

2013-01-01

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use (“redeployment”) of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research. PMID:24367341

The relation between finger gnosis and mathematical ability: why redeployment of neural circuits best explains the finding.

PubMed

Penner-Wilger, Marcie; Anderson, Michael L

2013-01-01

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use ("redeployment") of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research.

Future Directions in Research on Racism-Related Stress and Racial-Ethnic Protective Factors for Black Youth.

PubMed

Jones, Shawn C T; Neblett, Enrique W

2017-01-01

Research on racism-related stress and racial-ethnic protective factors represents an important enterprise for optimizing the mental health of African American and other racial and ethnic minority youth. However, there has been a relative dearth of work on these factors in the clinical psychology research literature, and more work is needed in outlets such as these. To this end, the current article adopts a developmental psychopathology framework and uses recent empirical findings to outline our current understanding of racism-related stress and racial-ethnic protective factors (i.e., racial identity, racial socialization, Africentric worldview) for African American youth. We then provide nine recommendations-across basic, applied, and broader/cross-cutting research lines-that we prioritize as essential to advancing the future scientific investigation of this crucial research agenda. Within and across these recommendations, we issue a charge to researchers and clinicians alike, with the ultimate goal of alleviating the negative mental health impact that racism-related stress can have on the well-being and mental health of African American and other racial and ethnic minority youth.

The case of Vipul Bhrigu and the federal definition of research misconduct.

PubMed

Rasmussen, Lisa M

2014-06-01

The Office of Research Integrity found in 2011 that Vipul Bhrigu, a postdoctoral researcher who sabotaged a colleague's research materials, was guilty of misconduct. However, I argue that this judgment is ill-considered and sets a problematic precedent for future cases. I first discuss the current federal definition of research misconduct and representative cases of research misconduct. Then, because this case recalls a debate from the 1990s over what the definition of "research misconduct" ought to be, I briefly recapitulate that history and reconsider the Bhrigu case in light of that history and in comparison to other cases involving tampering. Finally, I consider what the aim of a definition of research misconduct ought to be, and argue that the precedent set by the reasoning in this case is problematic.

Preparing Students for Careers in Science and Industry with Computational Physics

NASA Astrophysics Data System (ADS)

Florinski, V. A.

2011-12-01

Funded by NSF CAREER grant, the University of Alabama (UAH) in Huntsville has launched a new graduate program in Computational Physics. It is universally accepted that today's physics is done on a computer. The program blends the boundary between physics and computer science by teaching student modern, practical techniques of solving difficult physics problems using diverse computational platforms. Currently consisting of two courses first offered in the Fall of 2011, the program will eventually include 5 courses covering methods for fluid dynamics, particle transport via stochastic methods, and hybrid and PIC plasma simulations. The UAH's unique location allows courses to be shaped through discussions with faculty, NASA/MSFC researchers and local R&D business representatives, i.e., potential employers of the program's graduates. Students currently participating in the program have all begun their research careers in space and plasma physics; many are presenting their research at this meeting.

A proposal for a new multiaxial model of psychiatric diagnosis. A continuum-based patient model derived from evolutionary developmental gene-environment interaction.

PubMed

Leigh, Hoyle

2009-01-01

To review recent genetic and neuroscientific research on psychiatric syndromes based on the current diagnostic scheme, and develop a better-fitting multiaxial patient-oriented diagnostic model. DSM I, published in 1952, considered psychiatric illnesses as reactions or extremes of adaptations of the patient's personality to stressful environmental demands. Personality itself was determined by constitution and psychodynamic development. In 1980, this continuum model gave way to an atheoretical categorical diagnostic scheme (DSM III), based on research diagnostic criteria for obtaining 'pure cultures' of patients for biological research. Subsequent research using the 'pure cultures' suggests that psychiatric syndromes represent a phenotypic continuum determined by genes, childhood traumas, and recent stress, mitigated by childhood nurturance, education, and current social support. Specific gene x childhood abuse x recent stress interactions have been discovered, which may serve as a model of how interacting vulnerability genes may or may not result in a psychiatric syndrome, depending on the individual's developmental history and current stress. A continuum model is proposed, with genes interacting with early experiences of stress or nurturance resulting in brain states that may evince minor but persistent symptoms (neurosis) or maladaptive patterns of behavior (personality disorder). The addition of recent or current stress may precipitate a major psychiatric syndrome. While a severe genetic predisposition, such as a mutation, may be sufficient to cause a major syndrome, major psychiatric syndromes are best conceptualized as dysregulation of evolutionarily adaptive brain functions, such as anxiety and vigilance. A new multiaxial model of psychiatric diagnosis is proposed based on this model: axis I for phenomenological diagnoses that include major psychiatric syndromes (e.g. depressive syndrome, psychosis), neuroses, personality disorders, and isolated symptoms; axis II for geno-neuroscience diagnoses, some of which may represent biological conditions associated with axis I, i.e. genes, specific brain morphology, and the functional state of specific brain areas based on laboratory and imaging studies; axis III for medical diseases and conditions; axis IV for stress (childhood, recent, and current); axis V for psychosocial assets (intelligence, education, school/work, social support, and global assessment of functioning) over past 5 years and current. (c) 2008 S. Karger AG, Basel.

Moral Emotions and Moral Behavior

PubMed Central

Stuewig, Jeff; Mashek, Debra J.

2011-01-01

Moral emotions represent a key element of our human moral apparatus, influencing the link between moral standards and moral behavior. This chapter reviews current theory and research on moral emotions. We first focus on a triad of negatively valenced “self-conscious” emotions—shame, guilt, and embarrassment. As in previous decades, much research remains focused on shame and guilt. We review current thinking on the distinction between shame and guilt, and the relative advantages and disadvantages of these two moral emotions. Several new areas of research are highlighted: research on the domain-specific phenomenon of body shame, styles of coping with shame, psychobiological aspects of shame, the link between childhood abuse and later proneness to shame, and the phenomena of vicarious or “collective” experiences of shame and guilt. In recent years, the concept of moral emotions has been expanded to include several positive emotions—elevation, gratitude, and the sometimes morally relevant experience of pride. Finally, we discuss briefly a morally relevant emotional process—other-oriented empathy. PMID:16953797

Moral emotions and moral behavior.

PubMed

Tangney, June Price; Stuewig, Jeff; Mashek, Debra J

2007-01-01

Moral emotions represent a key element of our human moral apparatus, influencing the link between moral standards and moral behavior. This chapter reviews current theory and research on moral emotions. We first focus on a triad of negatively valenced "self-conscious" emotions-shame, guilt, and embarrassment. As in previous decades, much research remains focused on shame and guilt. We review current thinking on the distinction between shame and guilt, and the relative advantages and disadvantages of these two moral emotions. Several new areas of research are highlighted: research on the domain-specific phenomenon of body shame, styles of coping with shame, psychobiological aspects of shame, the link between childhood abuse and later proneness to shame, and the phenomena of vicarious or "collective" experiences of shame and guilt. In recent years, the concept of moral emotions has been expanded to include several positive emotions-elevation, gratitude, and the sometimes morally relevant experience of pride. Finally, we discuss briefly a morally relevant emotional process-other-oriented empathy.

Pheromone-Based Pest Management in China: Past, Present, and Future Prospects.

PubMed

Cui, Gen Zhong; Zhu, Junwei Jerry

2016-07-01

Semiochemical-based pest management technology has been widely used to monitor and control insect pests in agricultural, forestry, and public health sectors in the western world. It became a popular tool in the early 1970s with tremendous efforts in developing environment-friendly control technologies for the integrated pest management. However, in China, similar research lagged 15 to 20 years and was not initiated until the late 1980s. In this review, we present the early history of pheromone research that has led to the current practical applications in China, particularly in the development of pheromone-based pest management products. We also provide information regarding the current status of pheromone-based product manufacturing, marketing, and regulatory issues related to local semiochemical industries, which may be useful to other international companies interested in pursuing business in China. In addition, we share some research topics that represent new directions of the present pheromone research to explore novel tools for advancing semiochemical-based pest management in China.

CRISPR/Cas9 in Stem Cell Research: Current Application and Future Perspective.

PubMed

Patmanathan, Sathya Narayanan; Gnanasegaran, Nareshwaran; Lim, Moon Nian; Husaini, Roslina; Fakiruddin, Kamal Shaik; Zakaria, Zubaidah

2018-06-12

The clustered regularly interspaced short palindromic repeats-associated protein 9 or CRISPR/Cas9 system is one of the hottest topics discussed lately due to its robustness and effectiveness in genome editing. The technology has been widely used in life science research including microbial, plant, animal, and human cell studies. Combined with the pluripotency of stem cells, the technology represents a powerful tool to generate various cell types for disease modeling, drug screening, toxicology, and targeted therapies. Generally, the CRISPR/Cas9 system has been applied in genetic modification of pluripotent or multipotent stem cells, after which the cells are differentiated into specific cell types and used for functional analysis or even clinical transplantation. Recent advancement in CRISPR/Cas9 technology has widened the scope of stem cell research and its therapeutic application. This review provides an overview of the current application and the prospect of CRISPR/Cas9 technology, particularly in stem cell research and therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Base rate of performance invalidity among non-clinical undergraduate research participants.

PubMed

Silk-Eglit, Graham M; Stenclik, Jessica H; Gavett, Brandon E; Adams, Jason W; Lynch, Julie K; Mccaffrey, Robert J

2014-08-01

Neuropsychological research frequently uses non-clinical undergraduate participants to evaluate neuropsychological tests. However, a recent study by An and colleagues (2012, Archives of Clinical Neuropsychology, 27, 849-857) called into question that the extent to which the interpretation of these participants' performance on neuropsychological tests is valid. This study found that in a sample of 36 participants, 55.6% exhibited performance invalidity at an initial session and 30.8% exhibited performance invalidity at a follow-up session. The current study attempted to replicate these findings in a larger, more representative sample using a more rigorous methodology. Archival data from 133 non-clinical undergraduate research participants were analyzed. Participants were classified as performance invalid if they failed any one PVT. In the current sample, only 2.26% of participants exhibited performance invalidity. Thus, concerns regarding insufficient effort and performance invalidity when using undergraduate research participants appear to be overstated. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Let's Make Data Count

NASA Astrophysics Data System (ADS)

Budden, A. E.; Abrams, S.; Chodacki, J.; Cruse, P.; Fenner, M.; Jones, M. B.; Lowenberg, D.; Rueda, L.; Vieglais, D.

2017-12-01

The impact of research has traditionally been measured by citations to journal publications and used extensively for evaluation and assessment in academia, but this process misses the impact and reach of data and software as first-class scientific products. For traditional publications, Article-Level Metrics (ALM) capture the multitude of ways in which research is disseminated and used, such as references and citations within social media and other journal articles. Here we present on the extension of usage and citation metrics collection to include other artifacts of research, namely datasets. The Make Data Count (MDC) project will enable measuring the impact of research data in a manner similar to what is currently done with publications. Data-level metrics (DLM) are a multidimensional suite of indicators measuring the broad reach and use of data as legitimate research outputs. By making data metrics openly available for reuse in a number of different ways, the MDC project represents an important first step on the path towards the full integration of data metrics into the research data management ecosystem. By assuring researchers that their contributions to scholarly progress represented by data corpora are acknowledged, data level metrics provide a foundation for streamlining the advancement of knowledge by actively promoting desirable best practices regarding research data management, publication, and sharing.

Identifying seminal papers in the Australasian Journal on Ageing 1982-2011: a Delphi consensus approach.

PubMed

Parkinson, Lynne; Richardson, Kristy; Sims, Jane; Wells, Yvonne; Naganathan, Vasi; Brooke, Elizabeth; Lindley, Richard

2013-10-01

The aim of this study was to identify seminal Australasian Journal on Ageing papers published over 30 years through a Delphi consensus process. The main data collection was a three-round Delphi consensus study with 38 past and current members of the Australasian Journal on Ageing Editorial Board, Editorial Team and Management Committee. Three papers were agreed as top-ranking. One of the top-ranking articles was also highly cited. One article was published in the 1990 s, two in 2001. While it is difficult to judge how well the top-ranking papers represent seminal papers arising over 30 years, these papers do represent three different research strengths in Australasia, they do span three different disciplines, and they do reflect some of the diversity that characterises ageing research in Australasia over 30 years. © 2013 ACOTA.

Who is teaching the kids to cook? Results from a nationally representative survey of secondary school students in New Zealand.

PubMed

Utter, Jennifer; Denny, Simon; Lucassen, Mathijs; Dyson, Ben

2016-08-10

Learning how to cook is an important skill for developing healthy eating behaviors. Moreover, involvement in home cooking may offer young people opportunities for skill building, identity development and social engagement with their families. Recently, there have been concerns that the current generation of young people may not have the opportunities to develop sufficient cooking skills. These concerns have been addressed by the initiation of numerous, localized interventions. Yet, little is known about where the current generation of young people learn cooking skills. The objective of this study was to describe where the current generation of young people report learning to cook, drawing on nationally representative data from New Zealand. Data were collected as part of Youth2012, a nationally representative survey of secondary school students (n=8500) in New Zealand. Almost all students reported learning to cook and from multiple sources. Almost all students reported learning to cook from a family member (mother, father, or other family member), approximately 60% of students reported that they learned to cook from certain media (cookbooks, TV, or the Internet) and half of all students reported learning to cook at school. There were numerous differences in where students learned to cook by socio-demographic characteristics. Findings from the current research highlight the important role that families play in teaching young people to cook and will be useful for those working with young people to develop these skills.

Long-term effects on adult attachment in German occupation children born after World War II in comparison with a birth-cohort-matched representative sample of the German general population.

PubMed

Kaiser, Marie; Kuwert, Philipp; Braehler, Elmar; Glaesmer, Heide

2018-02-01

Children born of war are a phenomenon of every conflict. At the end of World War II and thereafter, approximately 400,000 children were fathered by foreign soldiers and born to local women in Germany. Quantitative research on psychosocial consequences of growing up as German occupation child (GOC) has been missing so far. This study examines adult attachment and its association with current depression in GOC (N = 146) using self-report instruments: Adult Attachment Scale, Patient Health Questionnaire. Data were compared to a birth-cohort-matched representative sample of the German population (BCMS; N = 786). GOC differ in both attachment dimensions (less comfortable with closeness/intimacy, lowered ability to depend on others) and adult attachment (more dismissive and fearful) compared to BCMS. Insecure adult attachment is associated with current depression. GOC grew up under difficult circumstances (e.g. poverty, adverse events, and stigmatization). Even decades later they display more insecure attachment in current relationships. Findings underline the complex and long-term impact of their developmental conditions on attachment and current mental health.

Assessing the Impact of Harassment by Peers: Incident Characteristics and Outcomes in a National Sample of Youth

ERIC Educational Resources Information Center

Turner, Heather A.; Mitchell, Kimberly J.; Jones, Lisa; Shattuck, Anne

2017-01-01

Although there are widely held assumptions about the characteristics of peer bullying that are of greatest concern, very few studies have empirically assessed which characteristics most affect its impact. The current research addresses this gap by using a nationally representative U.S. sample of youth ages 10-20 to examine the relative effects of…

Regional environmental analysis and management: New techniques for current problems

NASA Technical Reports Server (NTRS)

Honea, R. B.; Paludan, C. T. N.

1974-01-01

Advances in data acquisition and processing procedures for regional environmental analysis are discussed. Automated and semi-automated techniques employing Earth Resources Technology Satellite data and conventional data sources are presented. Experiences are summarized. The ERTS computer compatible tapes provide a very complete and flexible record of earth resources data and represent a viable medium to enhance regional environmental analysis research.

Identification and Development of Academic and Higher-Order Workplace Competencies in the Missouri Marketing Education Core Curriculum. Section I.

ERIC Educational Resources Information Center

Ruhland, Sheila K.; Wilkinson, Richard F.

This document provides an overview of a project to identify the basic academic skills, advanced academic skills, and the higher-order workplace competencies for marketing education. It describes the following project activities: review of current literature and research in the field; review by business and industry representatives of the skills…

Studies in Ambulatory Care Quality Assessment in the Indian Health Service. Volume II: Appraisal of System Performance.

ERIC Educational Resources Information Center

Nutting, Paul A.; And Others

Six Indian Health Service (IHS) units, chosen in a non-random manner, were evaluated via a quality assessment methodology currently under development by the IHS Office of Research and Development. A set of seven health problems (tracers) was selected to represent major health problems, and clinical algorithms (process maps) were constructed for…

The use of multiple imputation in the Southern Annual Forest Inventory System

Treesearch

Gregory A. Reams; Joseph M. McCollum

2000-01-01

The Southern Research Station is currently implementing an annual forest survey in 7 of the 13 States that it is responsible for surveying. The Southern Annual Forest Inventory System (SAFIS) sampling design is a systematic sample of five interpenetrating grids, whereby an equal number of plots are measured each year. The area-representative and time-series...

The use of multiple imputation in the Southern Annual Forest Inventory System

Treesearch

Gregory A. Reams; Joseph M. McCollum

2000-01-01

The Southern Research Station is currently implementing an annual forest survey in 7 of the 13 states that it is responsible for surveying. The Southern Annual Forest Inventory System (SAFIS) sampling design is a systematic sample of five interpenetrating grids, whereby an equal number of plots are measured each year. The area representative and time series nature of...

The Effect of Interactive e-Book on Students' Achievement at Najran University in Computer in Education Course

ERIC Educational Resources Information Center

Ebied, Mohammed Mohammed Ahmed; Rahman, Shimaa Ahmed Abdul

2015-01-01

The current study aims to examine the effect of interactive e-books on students' achievement at Najran University in computer in education course. Quasi-experimental study design is used in the study and to collect data the researchers built achievement test to measure the dependent variable represented in the achievement affected by experimental…

What Do Unions Do for Women? Research-in-Brief.

ERIC Educational Resources Information Center

Braunstein, Jill; And Others

Although union membership has been declining overall, the number of women union members continues to increase. Currently, 37 percent of union membership are women. The proportion of women workers who are union members increased from 16.3 percent in 1965 to 19.3 percent in 1975 and fell to 14 percent in 1990; 7.4 million women were represented by…

Orientation and Mobility with Persons Who Are Deaf-Blind: An Initial Examination of Single-Subject Design Research

ERIC Educational Resources Information Center

Parker, Amy T.

2009-01-01

Persons who are deaf-blind represent a heterogeneous, low-incidence population of children and adults who, at some point in life, regardless of the presence of additional disabilities, may benefit from formal orientation and mobility (O&M) instruction. Current national policies, such as the No Child Left Behind Act, which emphasize that…

Rural Adolescent Alcohol, Tobacco, and Illicit Drug Use: A Comparison of Students in Victoria, Australia, and Washington State, United States

ERIC Educational Resources Information Center

Coomber, Kerri; Toumbourou, John W.; Miller, Peter; Staiger, Petra K.; Hemphill, Sheryl A.; Catalano, Richard F.

2011-01-01

Purpose: There are inconsistent research findings regarding the impact of rurality on adolescent alcohol, tobacco, and illicit substance use. Therefore, the current study reports on the effect of rurality on alcohol, tobacco, and illicit drug use among adolescents in 2 state representative samples in 2 countries, Washington State (WA) in the…

USSR Report, Science and Technology Policy.

DTIC Science & Technology

1986-02-19

represent the policies, views or attitudes of the U.S. Government,, PROCUREMENT OF PUBLICATIONS JPRS publications may be ordered from the National...Washington, D.C 20402. Correspondence pertaining to matters other than procurement may be addressed to Joint Publications Research Service, 1000 North...which were busy with minor, current problems of production and had relaxed the search for promising directions, which guarantees progress of the

Quantifying simultaneous fluxes of ozone, carbon dioxide and water vapor above a subalpine forest ecosystem

Treesearch

K. F. Zeller; N. T. Nikolov

2000-01-01

Assessing the long-term exchange of trace gases and energy between terrestrial ecosystems and the atmosphere is an important priority of the current climate change research. In this regard, it is particularly significant to provide valid data on simultaneous fluxes of carbon, water vapor and pollutants over representative ecosystems. Eddy covariance measurements and...

That's a Tomato? Using a Familiar Food to Explore Genetic Variation

ERIC Educational Resources Information Center

Klosterman, Michelle L.; Chrispeels, Hanya E.; Reagan, Bryan R.; Lundy, Stacey R.; Browne, Carole L.; Muday, Gloria K.

2014-01-01

Like the figurative apple for the teacher, the tomato is a well-known food symbol representing a variety of cuisines. We drew on current scientific research and partnerships with classroom teachers to develop a case study activity consisting of four layers to teach concepts of plant biology and genetics to middle and high school students. The goal…

Unmanned aerial vehicles (UAVs) in pest management: Progress in the development of a UAV-deployed mating disruption system for Wisconsin cranberries

USDA-ARS?s Scientific Manuscript database

Unmanned aerial vehicles (UAVs) represent a powerful new tool for agriculture. Currently, UAVs are used almost exclusively as crop reconnaissance devices (“eyes in the sky”), not as pest control delivery systems. Research in Wisconsin cranberries is taking UAVs in a new direction. The Steffan and Lu...

Manifesting Destiny: Re/Presentations of Indigenous Peoples in K-12 U.S. History Standards

ERIC Educational Resources Information Center

Shear, Sarah B.; Knowles, Ryan T.; Soden, Gregory J.; Castro, Antonio J.

2015-01-01

In this mixed-methods study, we use a postcolonial framework to investigate how state standards represent Indigenous histories and cultures. The research questions that guided this study include: (a) What is the frequency of Indigenous content (histories, cultures, current issues) covered in state-level U.S. history standards for K-12? (b) What is…

Maternal Predictors of Noncoital Sexual Behavior: Examining a Nationally Representative Sample of Asian and White American Adolescents Who Have Never Had Sex

ERIC Educational Resources Information Center

Lam, Amy G.; Russell, Stephen T.; Tan, Thida C.; Leong, Sareen J.

2008-01-01

Current research in adolescent sexuality has largely focused on vaginal-penile intercourse, with less attention to noncoital sexual activity. This study examined how maternal factors influence the transition from virginity to noncoital behavior among White and Asian American youth who have never experienced vaginal intercourse. We conducted…

Are Early Childhood Disparities Narrowing? The Changing Nature of Early Childhood and Its Link to Narrowing School-Entry Achievement Gaps

ERIC Educational Resources Information Center

Bassok, Daphna; Finch, Jenna; Lee, RaeHyuck; Reardon, Sean F.; Waldfogel, Jane

2016-01-01

To date, no studies have documented how much early childhood experiences have changed over time. In the current study, researchers use two large, nationally representative datasets of kindergarten entrants to document the following: (1) How have children's early childhood experiences changed between 1998 and 2010?; (2) To what extent have…

Aliphatic, Cyclic, and Aromatic Organic Acids, Vitamins, and Carbohydrates in Soil: A Review

PubMed Central

Vranova, Valerie; Rejsek, Klement; Formanek, Pavel

2013-01-01

Organic acids, vitamins, and carbohydrates represent important organic compounds in soil. Aliphatic, cyclic, and aromatic organic acids play important roles in rhizosphere ecology, pedogenesis, food-web interactions, and decontamination of sites polluted by heavy metals and organic pollutants. Carbohydrates in soils can be used to estimate changes of soil organic matter due to management practices, whereas vitamins may play an important role in soil biological and biochemical processes. The aim of this work is to review current knowledge on aliphatic, cyclic, and aromatic organic acids, vitamins, and carbohydrates in soil and to identify directions for future research. Assessments of organic acids (aliphatic, cyclic, and aromatic) and carbohydrates, including their behaviour, have been reported in many works. However, knowledge on the occurrence and behaviour of D-enantiomers of organic acids, which may be abundant in soil, is currently lacking. Also, identification of the impact and mechanisms of environmental factors, such as soil water content, on carbohydrate status within soil organic matter remains to be determined. Finally, the occurrence of vitamins in soil and their role in biological and biochemical soil processes represent an important direction for future research. PMID:24319374

Aliphatic, cyclic, and aromatic organic acids, vitamins, and carbohydrates in soil: a review.

PubMed

Vranova, Valerie; Rejsek, Klement; Formanek, Pavel

2013-11-10

Organic acids, vitamins, and carbohydrates represent important organic compounds in soil. Aliphatic, cyclic, and aromatic organic acids play important roles in rhizosphere ecology, pedogenesis, food-web interactions, and decontamination of sites polluted by heavy metals and organic pollutants. Carbohydrates in soils can be used to estimate changes of soil organic matter due to management practices, whereas vitamins may play an important role in soil biological and biochemical processes. The aim of this work is to review current knowledge on aliphatic, cyclic, and aromatic organic acids, vitamins, and carbohydrates in soil and to identify directions for future research. Assessments of organic acids (aliphatic, cyclic, and aromatic) and carbohydrates, including their behaviour, have been reported in many works. However, knowledge on the occurrence and behaviour of D-enantiomers of organic acids, which may be abundant in soil, is currently lacking. Also, identification of the impact and mechanisms of environmental factors, such as soil water content, on carbohydrate status within soil organic matter remains to be determined. Finally, the occurrence of vitamins in soil and their role in biological and biochemical soil processes represent an important direction for future research.

Dental Use and Expenditures for Older Uninsured Americans: The Simulated Impact of Expanded Coverage

PubMed Central

Manski, Richard J; Moeller, John F; Chen, Haiyan; Schimmel, Jody; Pepper, John V; St Clair, Patricia A

2015-01-01

Objective To determine if providing dental insurance to older Americans would close the current gaps in dental use and expenditure between insured and uninsured older Americans. Data Sources/Study Setting We used data from the 2008 Health and Retirement Survey (HRS) supplemented by data from the 2006 Medical Expenditure Panel Survey (MEPS). Study Design We compared the simulated dental use and expenditures rates of newly insured persons against the corresponding rates for those previously insured. Data Collection/Extraction Methods The HRS is a nationally representative survey administered by the Institute for Social Research (ISR). The MEPS is a nationally representative household survey sponsored by the Agency for Healthcare Research and Quality (AHRQ). Principal Findings We found that expanding dental coverage to older uninsured Americans would close previous gaps in dental use and expense between uninsured and insured noninstitutionalized Americans 55 years and older. Conclusions Providing dental coverage to previously uninsured older adults would produce estimated monthly costs net of markups for administrative costs that comport closely to current market rates. Estimates also suggest that the total cost of providing dental coverage targeted specifically to nonusers of dental care may be less than similar costs for prior users. PMID:25040355

Bromamine Decomposition Revisited: A Holistic Approach for Analyzing Acid and Base Catalysis Kinetics.

PubMed

Wahman, David G; Speitel, Gerald E; Katz, Lynn E

2017-11-21

Chloramine chemistry is complex, with a variety of reactions occurring in series and parallel and many that are acid or base catalyzed, resulting in numerous rate constants. Bromide presence increases system complexity even further with possible bromamine and bromochloramine formation. Therefore, techniques for parameter estimation must address this complexity through thoughtful experimental design and robust data analysis approaches. The current research outlines a rational basis for constrained data fitting using Brønsted theory, application of the microscopic reversibility principle to reversible acid or base catalyzed reactions, and characterization of the relative significance of parallel reactions using fictive product tracking. This holistic approach was used on a comprehensive and well-documented data set for bromamine decomposition, allowing new interpretations of existing data by revealing that a previously published reaction scheme was not robust; it was not able to describe monobromamine or dibromamine decay outside of the conditions for which it was calibrated. The current research's simplified model (3 reactions, 17 constants) represented the experimental data better than the previously published model (4 reactions, 28 constants). A final model evaluation was conducted based on representative drinking water conditions to determine a minimal model (3 reactions, 8 constants) applicable for drinking water conditions.

An overview of cleaner fish use in Ireland.

PubMed

Bolton-Warberg, M

2017-11-21

Sea lice infestations represent one of the most significant challenges facing the salmon farming industry, giving rise to lost production, additional costs of treatment and potential negative interactions with wild stocks. At present, cleaner fish, which actively remove lice from salmon, are an effective, biological, long-term option which has been adopted by many countries. In Ireland, several key studies were conducted in the 1990s on the use of wild-caught wrasse (corkwing, goldsinny and rock cook) as cleaner fish in experimental and commercial scale trials. More recently, the National University of Ireland Galway (NUIG), at their marine research facility in Carna (CRS), has undertaken applied research on ballan wrasse and lumpsucker. Currently, CRS is providing lumpsucker juveniles and research and development for the Irish salmon industry with support from BIM (Ireland's Seafood Development Agency) and Marine Harvest Ireland. There is a large amount of research currently being carried out in this area in all countries that are utilizing cleaner fish technology. The current focus in Ireland is the development of a native lumpsucker broodstock to facilitate its sustainable production. The aim of this article was to provide an overview of the research, challenges and use of cleaner fish in Ireland. © 2017 The Authors Journal of Fish Diseases Published by John Wiley & Sons Ltd.

Structure and Evolution of Mediterranean Forest Research: A Science Mapping Approach.

PubMed

Nardi, Pierfrancesco; Di Matteo, Giovanni; Palahi, Marc; Scarascia Mugnozza, Giuseppe

2016-01-01

This study aims at conducting the first science mapping analysis of the Mediterranean forest research in order to elucidate its research structure and evolution. We applied a science mapping approach based on co-term and citation analyses to a set of scientific publications retrieved from the Elsevier's Scopus database over the period 1980-2014. The Scopus search retrieved 2,698 research papers and reviews published by 159 peer-reviewed journals. The total number of publications was around 1% (N = 17) during the period 1980-1989 and they reached 3% (N = 69) in the time slice 1990-1994. Since 1995, the number of publications increased exponentially, thus reaching 55% (N = 1,476) during the period 2010-2014. Within the thirty-four years considered, the retrieved publications were published by 88 countries. Among them, Spain was the most productive country, publishing 44% (N = 1,178) of total publications followed by Italy (18%, N = 482) and France (12%, N = 336). These countries also host the ten most productive scientific institutions in terms of number of publications in Mediterranean forest subjects. Forest Ecology and Management and Annals of Forest Science were the most active journals in publishing research in Mediterranean forest. During the period 1980-1994, the research topics were poorly characterized, but they become better defined during the time slice 1995-1999. Since 2000s, the clusters become well defined by research topics. Current status of Mediterranean forest research (20092014) was represented by four clusters, in which different research topics such as biodiversity and conservation, land-use and degradation, climate change effects on ecophysiological responses and soil were identified. Basic research in Mediterranean forest ecosystems is mainly conducted by ecophysiological research. Applied research was mainly represented by land-use and degradation, biodiversity and conservation and fire research topics. The citation analyses revealed highly cited terms in the Mediterranean forest research as they were represented by fire, biodiversity, carbon sequestration, climate change and global warming. Finally, our analysis also revealed the multidisciplinary role of climate change research. This study provides a first holistic view of the Mediterranean forest research that could be useful for researchers and policy makers as they may evaluate and analyze its historical evolution, as well as its structure and scientific production. We concluded that Mediterranean forest research represents an active scientific field.

Should We Care About Adolescents Who Care for Themselves? What We've Learned and What We Need to Know About Youth in Self-Care.

PubMed

Mahoney, Joseph L; Parente, Maria E

2009-12-01

This article provides an overview of existing research on the prevalence and predictors of adolescent self-care and on the consequences associated with it. Self-care, in which the young are left unsupervised during out-of-school hours, is a common experience for millions of American youth, and existing studies suggest that this arrangement may represent a risk for the development of behavior problems. However, the behavior problems associated with self-care depend on both individual and environmental factors and are most likely to develop when self-care (1) occurs out of the home, (2) involves permissive parenting and/or low parental monitoring, (3) takes place in neighborhoods with high levels of crime and disorganization, (4) involves adolescents with preexisting behavioral problems, and (5) represents an intensive and persistent arrangement. Following our survey of current research on self-care, we offer recommendations regarding future research and policy.

Accommodation requirements for microgravity science and applications research on space station

NASA Technical Reports Server (NTRS)

Uhran, M. L.; Holland, L. R.; Wear, W. O.

1985-01-01

Scientific research conducted in the microgravity environment of space represents a unique opportunity to explore and exploit the benefits of materials processing in the virtual abscence of gravity induced forces. NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. A study is performed to define from the researchers' perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. The accommodation requirements focus on the microgravity science disciplines including combustion science, electronic materials, metals and alloys, fluids and transport phenomena, glasses and ceramics, and polymer science. User requirements have been identified in eleven research classes, each of which contain an envelope of functional requirements for related experiments having similar characteristics, objectives, and equipment needs. Based on these functional requirements seventeen items of experiment apparatus and twenty items of core supporting equipment have been defined which represent currently identified equipment requirements for a pressurized laboratory module at the initial operating capability of the NASA space station.

Capture and Three Dimensional Projection of New South Wales Strata Plans in Landxml Format

NASA Astrophysics Data System (ADS)

Harding, B.; Foreman, A.

2017-10-01

New South Wales is embarking on a major reform program named Cadastre NSW. This reform aims to move to a single source of truth for the digital representation of cadastre. The current lack of a single source cadastre has hindered users from government and industry due to duplication of effort and misalignment between databases from different sources. For this reform to be successful, there are some challenges that need to be addressed. "Cadastre 2034 - Powering Land & Real Property" (2015) published by the Intergovernmental Committee on Surveying and Mapping (ICSM) identifies that current cadastres do not represent real property in three dimensions. In future vertical living lifestyles will create complex property scenarios that the Digital Cadastral Database (DCDB) will need to contend with. While the NSW DCDB currently holds over 3 million lots and 5 million features, one of its limitations is that it does not indicate land ownership above or below the ground surface. NSW Spatial Services is currently capturing survey plans into LandXML format. To prepare for the future, research is being undertaken to also capture multi-level Strata Plans through a modified recipe. During this research, multiple Strata Plans representing a range of ages and development types have been investigated and converted to LandXML. Since it is difficult to visualise the plans in a two dimensional format, quality control purposes require a method to display these plans in three dimensions. Overall investigations have provided Spatial Services with enough information to confirm that the capture and display of Strata Plans in the LandXML format is possible.

Committee on air pollution effects research: 40 years of UK air pollution.

PubMed

Fowler, David; Dise, Nancy; Sheppard, Lucy

2016-01-01

The UK Committee on Air Pollution Effects Research (CAPER) was established 40 years ago. This special section was compiled to mark this anniversary. During this time there have been dramatic changes in the composition of the air over the UK. The four papers in this special section of Environmental Pollution represent the current air pollution effects research focus on ozone and nitrogen deposition, two related issues and are proving from a policy perspective to be quite intractable issues. The UK CAPER research community continues to advance the underpinning science and engages closely with the user community in government departments. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

Modeling and Depletion Simulations for a High Flux Isotope Reactor Cycle with a Representative Experiment Loading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandler, David; Betzler, Ben; Hirtz, Gregory John

2016-09-01

The purpose of this report is to document a high-fidelity VESTA/MCNP High Flux Isotope Reactor (HFIR) core model that features a new, representative experiment loading. This model, which represents the current, high-enriched uranium fuel core, will serve as a reference for low-enriched uranium conversion studies, safety-basis calculations, and other research activities. A new experiment loading model was developed to better represent current, typical experiment loadings, in comparison to the experiment loading included in the model for Cycle 400 (operated in 2004). The new experiment loading model for the flux trap target region includes full length 252Cf production targets, 75Se productionmore » capsules, 63Ni production capsules, a 188W production capsule, and various materials irradiation targets. Fully loaded 238Pu production targets are modeled in eleven vertical experiment facilities located in the beryllium reflector. Other changes compared to the Cycle 400 model are the high-fidelity modeling of the fuel element side plates and the material composition of the control elements. Results obtained from the depletion simulations with the new model are presented, with a focus on time-dependent isotopic composition of irradiated fuel and single cycle isotope production metrics.« less

The potential of induced pluripotent stem cells in models of neurological disorders: implications on future therapy.

PubMed

Crook, Jeremy Micah; Wallace, Gordon; Tomaskovic-Crook, Eva

2015-03-01

There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings of conventional methods, enabling live human neural cell modeling of complex conditions relating to aberrant neurodevelopment, such as schizophrenia, epilepsy and autism as well as age-associated neurodegeneration. This review considers the current status of induced pluripotent stem cell-based modeling of neurological disorders, canvassing proven and putative advantages, current constraints, and future prospects of next-generation culture systems for biomedical research and translation.

Hardware-in-the-loop projector system for light detection and ranging sensor testing

NASA Astrophysics Data System (ADS)

Kim, Hajin J.; Naumann, Charles B.; Cornell, Michael C.

2012-08-01

Efforts in developing a synthetic environment for testing light detection and ranging (LADAR) sensors in a hardware-in-the-loop simulation are continuing at the Aviation and Missile Research, Engineering, and Development Center of the U.S. Army Research, Engineering and Development Command (RDECOM). Current activities have concentrated on evaluating the optical projection techniques for the LADAR synthetic environment. Schemes for generating the optical signals representing the individual pixels of the projection are of particular interest. Several approaches have been investigated and tested with emphasis on operating wavelength, intensity dynamic range and uniformity, and flexibility in pixel waveform generation. This paper will discuss some of the results from these current efforts at RDECOM's System Simulation and Development Directorate's Electro Optical Technology Development Laboratory.

Current preclinical models for the advancement of translational bladder cancer research.

PubMed

DeGraff, David J; Robinson, Victoria L; Shah, Jay B; Brandt, William D; Sonpavde, Guru; Kang, Yibin; Liebert, Monica; Wu, Xue-Ru; Taylor, John A

2013-02-01

Bladder cancer is a common disease representing the fifth most diagnosed solid tumor in the United States. Despite this, advances in our understanding of the molecular etiology and treatment of bladder cancer have been relatively lacking. This is especially apparent when recent advances in other cancers, such as breast and prostate, are taken into consideration. The field of bladder cancer research is ready and poised for a series of paradigm-shifting discoveries that will greatly impact the way this disease is clinically managed. Future preclinical discoveries with translational potential will require investigators to take full advantage of recent advances in molecular and animal modeling methodologies. We present an overview of current preclinical models and their potential roles in advancing our understanding of this deadly disease and for advancing care. ©2012 AACR.

Forgiveness and justice: a research agenda for social and personality psychology.

PubMed

Exline, Julie Juola; Worthington, Everett L; Hill, Peter; McCullough, Michael E

2003-01-01

Forgiveness and related constructs (e.g., repentance, mercy, reconciliation) are ripe for study by social and personality psychologists, including those interested in justice. Current trends in social science, law, management, philosophy, and theology suggest a need to expand existing justice frameworks to incorporate alternatives or complements to retribution, including forgiveness and related processes. In this article, we raise five challenging empirical questions about forgiveness. For each question, we briefly review representative research, raise hypotheses, and suggest specific ways in which social and personality psychologists could make distinctive contributions.

Solid earth science in the 1990s. Volume 1: Program plan

NASA Technical Reports Server (NTRS)

1991-01-01

This is volume one of a three volume series. A plan for solid earth science research for the next decade is outlined. The following topics are addressed: scientific requirements; status of current research; major new emphasis in the 1990's; interagency and international participation; and the program implementation plan. The following fields are represented: plate motion and deformation; lithospheric structure and evolution; volcanology; land surface (processes of change); earth structure and dynamics; earth rotation and reference frames; and geopotential fields. Other topics of discussion include remote sensing, space missions, and space techniques.

Space market model development project

NASA Technical Reports Server (NTRS)

Bishop, Peter C.

1987-01-01

The objectives of the research program, Space Market Model Development Project, (Phase 1) were: (1) to study the need for business information in the commercial development of space; and (2) to propose a design for an information system to meet the identified needs. Three simultaneous research strategies were used in proceeding toward this goal: (1) to describe the space business information which currently exists; (2) to survey government and business representatives on the information they would like to have; and (3) to investigate the feasibility of generating new economical information about the space industry.

Using Health Care Utilization and Publication Patterns to Characterize the Research Portfolio and to Plan Future Research Investments

PubMed Central

Katz, Luba; Fink, Rebecca V.; Bozeman, Samuel R.; McNeil, Barbara J.

2014-01-01

Objective Government funders of biomedical research are under increasing pressure to demonstrate societal benefits of their investments. A number of published studies attempted to correlate research funding levels with the societal burden for various diseases, with mixed results. We examined whether research funded by the Department of Veterans Affairs (VA) is well aligned with current and projected veterans’ health needs. The organizational structure of the VA makes it a particularly suitable setting for examining these questions. Methods We used the publication patterns and dollar expenditures of VA-funded researchers to characterize the VA research portfolio by disease. We used health care utilization data from the VA for the same diseases to define veterans’ health needs. We then measured the level of correlation between the two and identified disease groups that were under- or over-represented in the research portfolio relative to disease expenditures. Finally, we used historic health care utilization trends combined with demographic projections to identify diseases and conditions that are increasing in costs and/or patient volume and consequently represent potential targets for future research investments. Results We found a significant correlation between research volume/expenditures and health utilization. Some disease groups were slightly under- or over-represented, but these deviations were relatively small. Diseases and conditions with the increasing utilization trend at the VA included hypertension, hypercholesterolemia, diabetes, hearing loss, sleeping disorders, complications of pregnancy, and several mental disorders. Conclusions Research investments at the VA are well aligned with veteran health needs. The VA can continue to meet these needs by supporting research on the diseases and conditions with a growing number of patients, costs of care, or both. Our approach can be used by other funders of disease research to characterize their portfolios and to plan research investments. PMID:25493576

Enhancing the Careers of Under-Represented Junior Faculty in Biomedical Research: The Summer Institute Program to Increase Diversity (SIPID).

PubMed

Rice, Treva K; Liu, Li; Jeffe, Donna B; Jobe, Jared B; Boutjdir, Mohamed; Pace, Betty S; Rao, Dabeeru C

2014-01-01

The Summer Institute Program to Increase Diversity (SIPID) in Health-Related Research is a career advancement opportunity sponsored by the National Heart, Lung, and Blood Institute. Three mentored programs address difficulties experienced by junior investigators in establishing independent research careers and academic advancement. Aims are to increase the number of faculty from under-represented minority groups who successfully compete for external research funding. Data were collected using a centralized data-entry system from three Summer Institutes. Outcomes include mentees' satisfaction rating about the program, grant and publications productivity and specific comments. Fifty-eight junior faculty mentees (38% male) noticeably improved their rates of preparing/submitting grant applications and publications, with a 18-23% increase in confidence levels in planning and conducting research. According to survey comments, the training received in grantsmanship skills and one-on-one mentoring were the most valuable program components. The SIPID mentoring program was highly valued by the junior faculty mentees. The program will continue in 2011-2014 as PRIDE (PRogram to Increase Diversity among individuals Engaged in health-related research). Long-term follow-up of current mentees will be indexed at five years post training (2013). In summary, these mentoring programs hope to continue increasing the diversity of the next generation of scientists in biomedical research.

Sex offenders with intellectual disabilities and their academic observers: popular methodologies and research interests.

PubMed

Hollomotz, A

2014-02-01

Over the past two decades, disability activists and scholars have developed research paradigms that aim to place (some of the) control over the research process in the hands of disabled people. This paper discusses the appropriateness of applying such paradigms to sex offenders with intellectual disabilities (ID). It exposes to what extent current research about this population is affected by these developments. A content analysis of a sample of 80 articles across 20 academic journals was carried out. This recorded the data collection methods used, to what extent the views of people with ID were represented, subject affiliations of the authors and the subject matter discussed. Few studies make sense of the personal accounts of this population. Social scientists have mostly not engaged in this area of research, which results in significant gaps in knowledge. We currently know little about the subjectivity of sex offenders with ID. Research that seeks to explore this may enhance our understanding of this population and thus contribute towards the effectiveness of preventative work and risk management. © 2012 The Author. Journal of Intellectual Disability Research © 2012 John Wiley & Sons Ltd, MENCAP & IASSIDD.

Framework conditions facilitating paediatric clinical research

PubMed Central

2011-01-01

The use of unlicensed and "off-label" medicines in children is widespread. Between 50-80% of the medicines currently administered to children have neither been tested nor authorized for their use in the paediatric population which represents approximately 25% of the whole European population. On 26 January 2007, entered into force the European Regulation of Paediatric Medicines. It aims at the quality of research into medicines for children but without subjecting the paediatric population to unnecessary clinical trial. This article addresses ethical and legal issues arising from the regulation and makes recommendations for the framework conditions facilitating the development of clinical research with children. PMID:21345195

The Stanford how things work project

NASA Technical Reports Server (NTRS)

Fikes, Richard; Gruber, Tom; Iwasaki, Yumi

1994-01-01

We provide an overview of the Stanford How Things Work (HTW) project, an ongoing integrated collection of research activities in the Knowledge Systems Laboratory at Stanford University. The project is developing technology for representing knowledge about engineered devices in a form that enables the knowledge to be used in multiple systems for multiple reasoning tasks and reasoning methods that enable the represented knowledge to be effectively applied to the performance of the core engineering task of simulating and analyzing device behavior. The central new capabilities currently being developed in the project are automated assistance with model formulation and with verification that a design for an electro-mechanical device satisfies its functional specification.

Collaborative testing for key-term definitions under representative conditions: Efficiency costs and no learning benefits.

PubMed

Wissman, Kathryn T; Rawson, Katherine A

2018-01-01

Students are expected to learn key-term definitions across many different grade levels and academic disciplines. Thus, investigating ways to promote understanding of key-term definitions is of critical importance for applied purposes. A recent survey showed that learners report engaging in collaborative practice testing when learning key-term definitions, with outcomes also shedding light on the way in which learners report engaging in collaborative testing in real-world contexts (Wissman & Rawson, 2016, Memory, 24, 223-239). However, no research has directly explored the effectiveness of engaging in collaborative testing under representative conditions. Accordingly, the current research evaluates the costs (with respect to efficiency) and the benefits (with respect to learning) of collaborative testing for key-term definitions under representative conditions. In three experiments (ns = 94, 74, 95), learners individually studied key-term definitions and then completed retrieval practice, which occurred either individually or collaboratively (in dyads). Two days later, all learners completed a final individual test. Results from Experiments 1-2 showed a cost (with respect to efficiency) and no benefit (with respect to learning) of engaging in collaborative testing for key-term definitions. Experiment 3 evaluated a theoretical explanation for why collaborative benefits do not emerge under representative conditions. Collectively, outcomes indicate that collaborative testing versus individual testing is less effective and less efficient when learning key-term definitions under representative conditions.

Understanding and treatment of chronic pancreatitis.

PubMed

Drewes, Asbjørn Mohr

2013-11-14

Chronic pancreatitis is characterized by an inflammatory process of the pancreas, which is replaced by fibrosis and progressive destruction. The three major clinical features of chronic pancreatitis are pain, maldigestion, and diabetes. Chronic pancreatitis has a profound impact on social life and employment patterns. In the current issue, different topics highlight experimental models of chronic pancreatitis and bridge findings from recent research to bedside. Although the disease is still difficult to treat the current papers represent useful guidelines on how to approach chronic pancreatitis in the clinical settings with the major aim to improve the patient's suffering and quality of life.

The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.

PubMed

Hertweck, Kate L; Dasgupta, Santanu

2017-01-01

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both execute similar processes but with different cellular and molecular effects. Given the number of reviews currently available which describe the functional implications of mitochondrial mutations in cancer, this article focuses on documenting current knowledge in the abundance and distribution of somatic mitochondrial mutations, followed by elucidation of processes which affect the fate of mutations in cancer cells. The conclusion includes an overview of translational implications for mtDNA mutations, as well as recommendations for future research uniting mitochondrial variants and tumorigenesis.

Developments in School Finance, 2001-02. Fiscal Proceedings from the Annual State Data Conferences of July 2001 and July 2002.

ERIC Educational Resources Information Center

Fowler, William J., Jr., Ed.

The papers collected for this volume were selected from the fiscal proceedings of the 2001 and 2002 conferences of the National Center for Education Statistics. They represent current research in public-school education finance. The papers are as follows: "What We Know and What We Need to Know About Vouchers and Charter Schools" (Brian…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palumbo, Anthony V.

Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), the University of Tennessee (UT), and Florida State University (FSU). ORNL serves as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project is in its second year. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

The rainbow: from ancient Greece to modern optics.

PubMed

Schwab, Ivan R; Lee, W Barry; Bisno, David

2009-01-01

We provide a historical perspective on the rainbow, with a review of early research and observations regarding the rainbow's origin and a discussion of some of the major contributors to our current understanding of what the rainbow represents. An overview of the various types of rainbows is undertaken. We conclude with a discussion of the rainbow's link to refraction, light, the visual system, and perception.

Effect of a 15-Week Wellness Course on Health Indicators and Six Areas of Wellness in College Students

ERIC Educational Resources Information Center

Alameda, Andrea Michelle

2009-01-01

The current state of health of the United States, including physical inactivity, dietary intake, and overall lifestyle habits is of concern for educators. Specifically, the health of the college population appears to be under-represented in health and wellness research. The purpose of this study was to evaluate a 15-week university wellness-based…

Child Care: Exploring Private and Public Sector Approaches. Hearing before the Select Committee on Children, Youth, and Families. House of Representatives, Ninety-Eighth Congress, Second Session (San Francisco, CA, June 18, 1984).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

Testimony was heard concerning unmet needs for child care and current child care policy. Appearing before the Committee were California government officials, agency administrators and directors, school district officials, psychologists, anthropologists, and other researcher/practitioners, doctors, lawyers, parents, and children. Testimony covered…

Current Trends in School Finance: Massachusetts School Districts Are at a Fiscal Crossroads. Education Research Brief. Issue 1

ERIC Educational Resources Information Center

O'Donnell, Robert

2007-01-01

Funding public education represents a massive state and local effort. Spending on education is second only to Medicaid in terms of the overall state budget and it consumes the largest share of local tax revenues. Between state and local taxes, Massachusetts taxpayers spent nearly $11 billion to operate the Commonwealth's PK-12 education system in…

1-1 in Education: Current Practice, International Comparative Research Evidence and Policy Implications. OECD Education Working Papers, No. 44,

ERIC Educational Resources Information Center

Valiente, Oscar

2010-01-01

Over the last decade, more and more public and private stakeholders, in developed and developing countries, have been supporting 1:1 initiatives in education (i.e. every child receives her/his own personal computing device). These 1:1 initiatives represent a qualitative move forward from previous educational experiences with ICT, inasmuch as every…

Geoinformatics 2006--Abstracts

USGS Publications Warehouse

Brady, Shailaja R.; Sinha, A. Krishna; Gundersen, Linda C.

2006-01-01

In order to facilitate the discovery, integration, and analysis of distributed data, geoscientists-in partnership with information technologists and computer scientists-have established the emerging science of geoinformatics. Geoinformatics 2006, an international conference that was attended by over 300 participants between May 10 and 12, 2006, represents the first nationally organized meeting whose primary goal was to provide a forum for the exchange of the most current research in geoinformatics.

User evaluation of ride technology research

NASA Technical Reports Server (NTRS)

Mckenzie, J. R.; Brumaghim, S. H.

1976-01-01

The 23 organizations queried represent government, carrier, and manufacturing interests in air, marine, rail, and surface transportation systems. Results indicate a strong need for common terminology and data analysis/reporting techniques. The various types of ride criteria currently in use are discussed, particularly in terms of their respective data base requirements. A plan of action is proposed for fulfilling the ride technology needs identified by this study.

"Why Are We an Ignored Group?" Mainstream Educational Experiences and Current Life Satisfaction of Adults on the Autism Spectrum from an Online Survey

ERIC Educational Resources Information Center

Parsons, Sarah

2015-01-01

Adults on the autism spectrum are significantly under-represented in research on educational interventions and support, such that little is known about their views and experiences of schooling and how this prepared them for adult life. In addition, "good outcomes" in adult life are often judged according to normative assumptions and tend…

Meteoroids: The Smallest Solar System Bodies

NASA Technical Reports Server (NTRS)

Moser, Danielle E. (Compiler); Hardin, B. F. (Compiler); Janches, Diego (Compiler)

2011-01-01

This volume is a compilation of articles reflecting the current state of knowledge on the physics, chemistry, astronomy, and aeronomy of small bodies in the solar system. The articles included here represent the most recent results in meteor, meteoroid, and related research fields and were presented May 24-28, 2010, in Breckenridge, Colorado, USA at Meteoroids 2010: An International Conference on Minor Bodies in the Solar System.

Application of Biomarkers in the Development of Drugs Intended for the Treatment of Osteoarthritis

PubMed Central

Kraus, Virginia Byers; Burnett, Bruce; Coindreau, Javier; Cottrell, Susan; Eyre, David; Gendreau, Michael; Gardiner, Jennifer; Garnero, Patrick; Hardin, John; Henrotin, Yves; Heinegård, Dick; Ko, Amy; Lohmander, Stefan; Matthews, Gloria; Menetski, Joseph; Moskowitz, Roland; Persiani, Stefano; Poole, Robin; Rousseau, Jean Charles; Todman, Martin

2013-01-01

Objective Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug discovery and development programs. The goal of this document is to provide a summary and guide to the application of in vitro (biochemical and other soluble) biomarkers in the development of drugs for OA and to outline and stimulate a research agenda that will further this goal. Methods The Biomarkers Working Group representing experts in the field of OA biomarker research from both academia and industry developed this consensus document between 2007–2009 at the behest of the Osteoarthritis Research Society International (OARSI FDA initiative). Results This document summarizes definitions and classification systems for biomarkers, the current outcome measures used in OA clinical trials, applications and potential utility of biomarkers for development of OA therapeutics, the current state of qualification of OA-related biomarkers, pathways for biomarker qualification, critical needs to advance the use of biomarkers for drug development, recommendations regarding practices and clinical trials, and a research agenda to advance the science of OA-related biomarkers. Conclusions Although many OA-related biomarkers are currently available they exist in various states of qualification and validation. The biomarkers that are likely to have the earliest beneficial impact on clinical trials fall into two general categories, those that will allow targeting of subjects most likely to either respond and/or progress (prognostic value) within a reasonable and manageable time frame for a clinical study (for instance within one to two years for an OA trial), and those that provide early feedback for preclinical decision-making and for trial organizers that a drug is having the desired biochemical effect. As in vitro biomarkers are increasingly investigated in the context of specific drug treatments, advances in the field can be expected that will lead to rapid expansion of the list of available biomarkers with increasing understanding of the molecular processes that they represent. PMID:21396468

Deficits in Category Learning in Older Adults: Rule-Based Versus Clustering Accounts

PubMed Central

2017-01-01

Memory research has long been one of the key areas of investigation for cognitive aging researchers but only in the last decade or so has categorization been used to understand age differences in cognition. Categorization tasks focus more heavily on the grouping and organization of items in memory, and often on the process of learning relationships through trial and error. Categorization studies allow researchers to more accurately characterize age differences in cognition: whether older adults show declines in the way in which they represent categories with simple rules or declines in representing categories by similarity to past examples. In the current study, young and older adults participated in a set of classic category learning problems, which allowed us to distinguish between three hypotheses: (a) rule-complexity: categories were represented exclusively with rules and older adults had differential difficulty when more complex rules were required, (b) rule-specific: categories could be represented either by rules or by similarity, and there were age deficits in using rules, and (c) clustering: similarity was mainly used and older adults constructed a less-detailed representation by lumping more items into fewer clusters. The ordinal levels of performance across different conditions argued against rule-complexity, as older adults showed greater deficits on less complex categories. The data also provided evidence against rule-specificity, as single-dimensional rules could not explain age declines. Instead, computational modeling of the data indicated that older adults utilized fewer conceptual clusters of items in memory than did young adults. PMID:28816474

Composite Bone Models in Orthopaedic Surgery Research and Education

PubMed Central

Elfar, John; Stanbury, Spencer; Menorca, Ron Martin Garcia; Reed, Jeffrey Douglas

2014-01-01

Composite bone models are increasingly used in orthopaedic biomechanics research and surgical education—applications that traditionally relied on cadavers. Cadaver bones are suboptimal for myriad reasons, including issues of cost, availability, preservation, and inconsistency between specimens. Further, cadaver samples disproportionately represent the elderly, whose bone quality may not be representative of the greater orthopaedic population. The current fourth-generation composite bone models provide an accurate reproduction of the biomechanical properties of human bone when placed under bending, axial, and torsional loads. The combination of glass fiber and epoxy resin components into a single phase has enabled manufacturing by injection molding. The high anatomic fidelity of the cadaver-based molds and negligible shrinkage properties of the epoxy resin results in a process that allows for excellent definition of anatomic detail in the cortical wall and optimized consistency of features between models. Recent biomechanical studies of composites have validated their use as a suitable substitute for cadaver specimens. PMID:24486757

Composite bone models in orthopaedic surgery research and education.

PubMed

Elfar, John; Menorca, Ron Martin Garcia; Reed, Jeffrey Douglas; Stanbury, Spencer

2014-02-01

Composite bone models are increasingly used in orthopaedic biomechanics research and surgical education-applications that traditionally relied on cadavers. Cadaver bones are suboptimal for many reasons, including issues of cost, availability, preservation, and inconsistency between specimens. Further, cadaver samples disproportionately represent the elderly, whose bone quality may not be representative of the greater orthopaedic population. The current fourth-generation composite bone models provide an accurate reproduction of the biomechanical properties of human bone when placed under bending, axial, and torsional loads. The combination of glass fiber and epoxy resin components into a single phase has enabled manufacturing by injection molding. The high level of anatomic fidelity of the cadaver-based molds and negligible shrinkage properties of the epoxy resin results in a process that allows for excellent definition of anatomic detail in the cortical wall and optimized consistency of features between models. Recent biomechanical studies of composites have validated their use as a suitable substitute for cadaver specimens.

Advanced Industrial Materials (AIM) fellowship program

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCleary, D.D.

1997-04-01

The Advanced Industrial Materials (AIM) Program administers a Graduate Fellowship Program focused toward helping students who are currently under represented in the nation`s pool of scientists and engineers, enter and complete advanced degree programs. The objectives of the program are to: (1) establish and maintain cooperative linkages between DOE and professors at universities with graduate programs leading toward degrees or with degree options in Materials Science, Materials Engineering, Metallurgical Engineering, and Ceramic Engineering, the disciplines most closely related to the AIM Program at Oak Ridge National Laboratory (ORNL); (2) strengthen the capabilities and increase the level of participation of currentlymore » under represented groups in master`s degree programs, and (3) offer graduate students an opportunity for practical research experience related to their thesis topic through the three-month research assignment or practicum at ORNL. The program is administered by the Oak Ridge Institute for Science and Education (ORISE).« less

Factors influencing research engagement: research interest, confidence and experience in an Australian speech-language pathology workforce.

PubMed

Finch, Emma; Cornwell, Petrea; Ward, Elizabeth C; McPhail, Steven M

2013-04-19

Recent initiatives within an Australia public healthcare service have seen a focus on increasing the research capacity of their workforce. One of the key initiatives involves encouraging clinicians to be research generators rather than solely research consumers. As a result, baseline data of current research capacity are essential to determine whether initiatives encouraging clinicians to undertake research have been effective. Speech pathologists have previously been shown to be interested in conducting research within their clinical role; therefore they are well positioned to benefit from such initiatives. The present study examined the current research interest, confidence and experience of speech language pathologists (SLPs) in a public healthcare workforce, as well as factors that predicted clinician research engagement. Data were collected via an online survey emailed to an estimated 330 SLPs working within Queensland, Australia. The survey consisted of 30 questions relating to current levels of interest, confidence and experience performing specific research tasks, as well as how frequently SLPs had performed these tasks in the last 5 years. Although 158 SLPs responded to the survey, complete data were available for only 137. Respondents were more confident and experienced with basic research tasks (e.g., finding literature) and less confident and experienced with complex research tasks (e.g., analysing and interpreting results, publishing results). For most tasks, SLPs displayed higher levels of interest in the task than confidence and experience. Research engagement was predicted by highest qualification obtained, current job classification level and overall interest in research. Respondents generally reported levels of interest in research higher than their confidence and experience, with many respondents reporting limited experience in most research tasks. Therefore SLPs have potential to benefit from research capacity building activities to increase their research skills in order to meet organisational research engagement objectives. However, these findings must be interpreted with the caveats that a relatively low response rate occurred and participants were recruited from a single state-wide health service, and therefore may not be representative of the wider SLP workforce.

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities.

PubMed

Pistollato, Francesca; Ohayon, Elan L; Lam, Ann; Langley, Gillian R; Novak, Thomas J; Pamies, David; Perry, George; Trushina, Eugenia; Williams, Robin S B; Roher, Alex E; Hartung, Thomas; Harnad, Stevan; Barnard, Neal; Morris, Martha Clare; Lai, Mei-Chun; Merkley, Ryan; Chandrasekera, P Charukeshi

2016-06-28

Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and exciting tools to enhance and forward AD research. In particular, these methods are helping advance AD research by contributing multifactorial and multidimensional perspectives, especially considering the crucial role played by lifestyle risk factors in the determination of AD risk. In addition to research techniques, we also consider related pitfalls and flaws in the current research funding system. Conversely, we identify encouraging new trends in research and government policy. In light of these new research directions, we provide recommendations regarding prioritization of research funding. The goal of this document is to stimulate scientific and public discussion on the need to explore new avenues in AD research, considering outcome and ethics as core principles to reliably judge traditional research efforts and eventually undertake new research strategies.

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

PubMed Central

Pistollato, Francesca; Ohayon, Elan L.; Lam, Ann; Langley, Gillian R.; Novak, Thomas J.; Pamies, David; Perry, George; Trushina, Eugenia; Williams, Robin S.B.; Roher, Alex E.; Hartung, Thomas; Harnad, Stevan; Barnard, Neal; Morris, Martha Clare; Lai, Mei-Chun; Merkley, Ryan; Chandrasekera, P. Charukeshi

2016-01-01

Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and exciting tools to enhance and forward AD research. In particular, these methods are helping advance AD research by contributing multifactorial and multidimensional perspectives, especially considering the crucial role played by lifestyle risk factors in the determination of AD risk. In addition to research techniques, we also consider related pitfalls and flaws in the current research funding system. Conversely, we identify encouraging new trends in research and government policy. In light of these new research directions, we provide recommendations regarding prioritization of research funding. The goal of this document is to stimulate scientific and public discussion on the need to explore new avenues in AD research, considering outcome and ethics as core principles to reliably judge traditional research efforts and eventually undertake new research strategies. PMID:27229915

Primary Prevention of Sexual Violence in Aotearoa New Zealand.

PubMed

Dickson, Sandra; Willis, Gwenda M

2017-03-01

The extensive and sometimes profoundly damaging effects of sexual violence and large numbers of victims necessitate dedicated attention to primary prevention efforts. Few studies have examined the scope of current prevention activities or their fit with empirical research into effective prevention strategies. The current article presents findings from a survey of primary prevention activities in non-Māori and bicultural communities within Aotearoa New Zealand. Forty-four respondents representing 42 agencies responded to a comprehensive survey that canvased types of sexual violence primary prevention activities undertaken, sexual violence primary prevention programs, and barriers and supports to sexual violence prevention work. Consistent with findings from previous international surveys, the focus of primary prevention work in New Zealand was on sexual violence education and increasing awareness. Findings are discussed in the context of the sexual violence prevention literature and what works in prevention more broadly to help identify promising initiatives as well as gaps in current practices. Recommendations for advancing sexual violence primary prevention research are also provided.

Ten Demands of Improved Usability in eHealth and Some Progress - Co-Creation by Health and Social Care Professionals.

PubMed

Scandurra, Isabella; Liljequist, David

2016-01-01

Current healthcare organizations often do not accomplish the intended effects of their eHealth systems due to inadequate usability. Commissioned by the Swedish Ministry of Health and Social Affairs, the usability of current eHealth systems in Swedish health and social care has been analysed from the perspective of their professionals. The objective of the study was to report on current problems, potential solutions as well as to relate these to research in relevant areas. Using a participatory approach, nine workshops were held where health informatics researchers guided staff from different care organizations, representatives of the national associations of health and social care professionals and the national eHealth system vendor organization. This paper presents ten demands that Swedish health and social care professionals find imperative to prioritize. The study emphasizes that development of eHealth systems must be integrated into the care practice improvement process and iteratively evaluated regarding usability.

Risk of co-occuring psychopathology: testing a prediction of expectancy theory.

PubMed

Capron, Daniel W; Norr, Aaron M; Schmidt, Norman B

2013-01-01

Despite the high impact of anxiety sensitivity (AS; a fear of anxiety related sensations) research, almost no research attention has been paid to its parent theory, Reiss' expectancy theory (ET). ET has gone largely unexamined to this point, including the prediction that AS is a better predictor of number of fears than current anxiety. To test Reiss' prediction, we used a large (N = 317) clinical sample of anxiety outpatients. Specifically, we examined whether elevated AS predicted number of comorbid anxiety and non-anxiety disorder diagnoses in this sample. Consistent with ET, findings indicated that AS predicted number of comorbid anxiety disorder diagnoses above and beyond current anxiety symptoms. Also, AS did not predict the number of comorbid non-anxiety diagnoses when current anxiety symptoms were accounted for. These findings represent an important examination of a prediction of Reiss' ET and are consistent with the idea that AS may be a useful transdiagnostic treatment target. Copyright © 2012 Elsevier Ltd. All rights reserved.

Priorities for Cardiovascular Outcomes Research: A Report of the National Heart, Lung, and Blood Institute's Centers for Cardiovascular Outcomes Research Working Group.

PubMed

Khazanie, Prateeti; Krumholz, Harlan M; Kiefe, Catarina I; Kressin, Nancy R; Wells, Barbara; Wang, Tracy Y; Peterson, Eric D

2017-07-01

The Centers for Cardiovascular Outcomes Research (CCORs) held a meeting to review how cardiovascular outcomes research had evolved in the decade since the National Heart, Lung, and Blood Institute 2004 working group report and to consider future directions. The conference involved representatives from governmental agencies, outcomes research thought leaders, and public and private healthcare partners. The main purposes of this meeting were to (1) advance collaborative high-yield, high-impact outcomes research; (2) identify priorities and barriers to important cardiovascular outcomes research; and (3) define future needs for the field. This report highlights the key topics covered during the meeting, including an examination of the recent history of outcomes research, an evaluation of the current academic climate, and a vision for the future of cardiovascular outcomes research. © 2017 American Heart Association, Inc.

The U.S.-Russian radiation health effects research program in the Southern Urals.

PubMed

Seligman, P J

2000-07-01

The Joint Coordinating Committee for Radiation Effects Research (JCCRER) was established through a bilateral U.S.-Russian agreement to support research and exchange information on radiation health effects. The U.S. member agencies include the Department of Energy (DOE), Nuclear Regulatory Commission (NRC), Department of Health and Human Services (DHHS), Department of Defense (DoD), National Aeronautics and Space Administration (NASA), and Environmental Protection Agency (EPA). The Russians are represented by the Ministries of Emergencies (EMERCOM), Atomic Energy (MINATOM) and Health (MINZDRAV), and the Russian Academy of Sciences (IBRAE). The focus of this research is on the workers from the Mayak Production Association (MAYAK) in the Southern Urals and on the neighboring populations along the Techa River exposed to contamination from the plant. The goal of the program is to better define the relationship between the health effects and the chronic low dose and dose-rate exposure, these data being essential to validate current radiation protection standards and practices. The current primary areas of JCCRER research include dose reconstruction, epidemiologic health studies, molecular epidemiology/biodosimetry, and the creation of tissue banks. The organization of the ongoing research conducted under the aegis of the JCCRER and the rationale for this work are described.

Researching older lesbians: problems and partial solutions.

PubMed

Westwood, Sue

2013-01-01

There is a lack of research about older lesbians, who can be considered not only a "hidden population" but also a population in hiding. Yet older lesbians hold vital historical and cultural narratives that are, in turn, the heritage of younger lesbians. They also have much to contribute to understandings about gender, sexuality and aging, and to their currently unmet needs in terms of age-related housing, health, and social care provision. This article reflects on some of the issues that make it difficult to access older lesbians for research purposes. It identifies four problematic areas in researching older lesbians: definitions, access, representative sampling, and ethical issues. It suggests that participative action research might offer a means of widening access and engaging with older lesbians in a more collaborative way.

International Low-Earth-Orbit Spacecraft Materials Test Program Initiated for Better Prediction of Durability and Performance

NASA Technical Reports Server (NTRS)

Rutledge, Sharon K.

1999-01-01

Spacecraft in low Earth orbit (LEO) are subjected to many components of the environment, which can cause them to degrade much more rapidly than intended and greatly shorten their functional life. The atomic oxygen, ultraviolet radiation, and cross contamination present in LEO can affect sensitive surfaces such as thermal control paints, multilayer insulation, solar array surfaces, and optical surfaces. The LEO Spacecraft Materials Test (LEO-SMT) program is being conducted to assess the effects of simulated LEO exposure on current spacecraft materials to increase understanding of LEO degradation processes as well as to enable the prediction of in-space performance and durability. Using ground-based simulation facilities to test the durability of materials currently flying in LEO will allow researchers to compare the degradation evidenced in the ground-based facilities with that evidenced on orbit. This will allow refinement of ground laboratory test systems and the development of algorithms to predict the durability and performance of new materials in LEO from ground test results. Accurate predictions based on ground tests could reduce development costs and increase reliability. The wide variety of national and international materials being tested represent materials being functionally used on spacecraft in LEO. The more varied the types of materials tested, the greater the probability that researchers will develop and validate predictive models for spacecraft long-term performance and durability. Organizations that are currently participating in the program are ITT Research Institute (USA), Lockheed Martin (USA), MAP (France), SOREQ Nuclear Research Center (Israel), TNO Institute of Applied Physics (The Netherlands), and UBE Industries, Ltd. (Japan). These represent some of the major suppliers of thermal control and sensor materials currently flying in LEO. The participants provide materials that are exposed to selected levels of atomic oxygen, vacuum ultraviolet radiation, contamination, or synergistic combined environments at the NASA Lewis Research Center. Changes in characteristics that could affect mission performance or lifetime are then measured. These characteristics include changes in mass, solar absorptance, and thermal emittance. The durability of spacecraft materials from U.S. suppliers is then compared with those of materials from other participating countries. Lewis will develop and validate performance and durability prediction models using this ground data and available space data. NASA welcomes the opportunity to consider additional international participants in this program, which should greatly aid future spacecraft designers as they select materials for LEO missions.

Ebola: A holistic approach is required to achieve effective management and control

PubMed Central

Roca, Anna; Afolabi, Muhammed O.; Saidu, Yauba; Kampmann, Beate

2015-01-01

The current Ebola outbreak in West Africa has already caused substantial mortality and dire human and economic consequences. It continues to represent an alarming public health threat in the region and beyond and jeopardizes the provision of health care and other services in the affected countries. The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding. Our knowledge relating to the virus, disease pathogenesis, risk factors, dynamics of transmission, and epidemic control is increasing, and sociocultural factors have emerged as critical determinants for the success and failure of control efforts. However, there is a long way to go. In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research. PMID:25843598

Pharmacologic Treatment of Wet Type Age-related Macular Degeneration; Current and Evolving Therapies.

PubMed

Shams Najafabadi, Hoda; Daftarian, Narsis; Ahmadieh, Hamid; Soheili, Zahra-Soheila

2017-08-01

Age-related macular degeneration as the major cause of blindness in the elderly population has remained at the epicenter of clinical research in ophthalmology. This retinal disorder is characterized by the photoreceptor and retinal pigment epithelial cells loss, occurring within the macula. The disease represents a spectrum of clinical manifestations. It is a multifactorial disease resulting from a combination of genetic predispositions and environmental risk factors. AMD is classified into two different types, dry and wet. Wet AMD is in close relation with angiogenesis and inflammatory processes.A variety of anti-angiogenesis and anti-inflammatory drugs have been proposed for the treatment of the disease. The purpose of this paper is to briefly review the pharmacological therapies of the wet form of AMD and focus on new drugs that are currently in different stages of research and development.

A Review of Current Neuromorphic Approaches for Vision, Auditory, and Olfactory Sensors.

PubMed

Vanarse, Anup; Osseiran, Adam; Rassau, Alexander

2016-01-01

Conventional vision, auditory, and olfactory sensors generate large volumes of redundant data and as a result tend to consume excessive power. To address these shortcomings, neuromorphic sensors have been developed. These sensors mimic the neuro-biological architecture of sensory organs using aVLSI (analog Very Large Scale Integration) and generate asynchronous spiking output that represents sensing information in ways that are similar to neural signals. This allows for much lower power consumption due to an ability to extract useful sensory information from sparse captured data. The foundation for research in neuromorphic sensors was laid more than two decades ago, but recent developments in understanding of biological sensing and advanced electronics, have stimulated research on sophisticated neuromorphic sensors that provide numerous advantages over conventional sensors. In this paper, we review the current state-of-the-art in neuromorphic implementation of vision, auditory, and olfactory sensors and identify key contributions across these fields. Bringing together these key contributions we suggest a future research direction for further development of the neuromorphic sensing field.

Wildfire smoke exposure and human health: Significant gaps in research for a growing public health issue.

PubMed

Black, Carolyn; Tesfaigzi, Yohannes; Bassein, Jed A; Miller, Lisa A

2017-10-01

Understanding the effect of wildfire smoke exposure on human health represents a unique interdisciplinary challenge to the scientific community. Population health studies indicate that wildfire smoke is a risk to human health and increases the healthcare burden of smoke-impacted areas. However, wildfire smoke composition is complex and dynamic, making characterization and modeling difficult. Furthermore, current efforts to study the effect of wildfire smoke are limited by availability of air quality measures and inconsistent air quality reporting among researchers. To help address these issues, we conducted a substantive review of wildfire smoke effects on population health, wildfire smoke exposure in occupational health, and experimental wood smoke exposure. Our goal was to evaluate the current literature on wildfire smoke and highlight important gaps in research. In particular we emphasize long-term health effects of wildfire smoke, recovery following wildfire smoke exposure, and health consequences of exposure in children. Copyright © 2017 Elsevier B.V. All rights reserved.

Refining Current Scientific Priorities and Identifying New Scientific Gaps in HIV-Related Heart, Lung, Blood, and Sleep Research.

PubMed

Twigg, Homer L; Crystal, Ronald; Currier, Judith; Ridker, Paul; Berliner, Nancy; Kiem, Hans-Peter; Rutherford, George; Zou, Shimian; Glynn, Simone; Wong, Renee; Peprah, Emmanuel; Engelgau, Michael; Creazzo, Tony; Colombini-Hatch, Sandra; Caler, Elisabet

2017-09-01

The National Heart, Lung, and Blood Institute (NHLBI) AIDS Program's goal is to provide direction and support for research and training programs in areas of HIV-related heart, lung, blood, and sleep (HLBS) diseases. To better define NHLBI current HIV-related scientific priorities and with the goal of identifying new scientific priorities and gaps in HIV-related HLBS research, a wide group of investigators gathered for a scientific NHLBI HIV Working Group on December 14-15, 2015, in Bethesda, MD. The core objectives of the Working Group included discussions on: (1) HIV-related HLBS comorbidities in the antiretroviral era; (2) HIV cure; (3) HIV prevention; and (4) mechanisms to implement new scientific discoveries in an efficient and timely manner so as to have the most impact on people living with HIV. The 2015 Working Group represented an opportunity for the NHLBI to obtain expert advice on HIV/AIDS scientific priorities and approaches over the next decade.

Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions

NASA Technical Reports Server (NTRS)

DellaCorte, Chris; Pinkus, Oscar

2000-01-01

The following report represents a compendium of selected speaker presentation materials and observations made by Prof O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on Tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic beatings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions. Revised

NASA Technical Reports Server (NTRS)

DellaCorte, Chris; Pinkus, Oscar

2002-01-01

The following report represents a compendium of selected speaker presentation materials and observations made by Prof. O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial, and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic bearings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

The necessity of animal models in pain research.

PubMed

Mogil, Jeffrey S; Davis, Karen D; Derbyshire, Stuart W

2010-10-01

There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain. We discuss the inherent advantage of animal models over human research as well as the crucial complementary roles animal studies play vis-à-vis human imaging and genetic studies. Finally, we discuss recent developments in animal models of pain that should improve the relevance and translatability of findings using laboratory animals. We believe that pain research using animal models is a continuing necessity-to understand fundamental mechanisms, identify new analgesic targets, and inform, guide and follow up human studies-if novel analgesics are to be developed for the treatment of chronic pain. Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Experimental Methods in Reduced-gravity Soldering Research

NASA Technical Reports Server (NTRS)

Pettegrew, Richard D.; Struk, Peter M.; Watson, John K.; Haylett, Daniel R.

2002-01-01

The National Center for Microgravity Research, NASA Glenn Research Center, and NASA Johnson Space Center are conducting an experimental program to explore the influence of reduced gravity environments on the soldering process. An improved understanding of the effects of the acceleration environment is important to application of soldering during current and future human space missions. Solder joint characteristics that are being considered include solder fillet geometry, porosity, and microstructural features. Both through-hole and surface mounted devices are being investigated. This paper focuses on the experimental methodology employed in this project and the results of macroscopic sample examination. The specific soldering process, sample configurations, materials, and equipment were selected to be consistent with those currently on-orbit. Other apparatus was incorporated to meet requirements imposed by operation onboard NASA's KC-135 research aircraft and instrumentation was provided to monitor both the atmospheric and acceleration environments. The contingent of test operators was selected to include both highly skilled technicians and less skilled individuals to provide a population cross-section that would be representative of the skill mix that might be encountered in space mission crews.

On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis

PubMed Central

Blasco-Gómez, Ramiro; Batlle-Vilanova, Pau; Villano, Marianna; Balaguer, Maria Dolors; Colprim, Jesús; Puig, Sebastià

2017-01-01

The conversion of electrical current into methane (electromethanogenesis) by microbes represents one of the most promising applications of bioelectrochemical systems (BES). Electromethanogenesis provides a novel approach to waste treatment, carbon dioxide fixation and renewable energy storage into a chemically stable compound, such as methane. This has become an important area of research since it was first described, attracting different research groups worldwide. Basics of the process such as microorganisms involved and main reactions are now much better understood, and recent advances in BES configuration and electrode materials in lab-scale enhance the interest in this technology. However, there are still some gaps that need to be filled to move towards its application. Side reactions or scaling-up issues are clearly among the main challenges that need to be overcome to its further development. This review summarizes the recent advances made in the field of electromethanogenesis to address the main future challenges and opportunities of this novel process. In addition, the present fundamental knowledge is critically reviewed and some insights are provided to identify potential niche applications and help researchers to overcome current technological boundaries. PMID:28425974

Atmospheric processes over complex terrain

NASA Astrophysics Data System (ADS)

Banta, Robert M.; Berri, G.; Blumen, William; Carruthers, David J.; Dalu, G. A.; Durran, Dale R.; Egger, Joseph; Garratt, J. R.; Hanna, Steven R.; Hunt, J. C. R.

1990-06-01

A workshop on atmospheric processes over complex terrain, sponsored by the American Meteorological Society, was convened in Park City, Utah from 24 vto 28 October 1988. The overall objective of the workshop was one of interaction and synthesis--interaction among atmospheric scientists carrying out research on a variety of orographic flow problems, and a synthesis of their results and points of view into an assessment of the current status of topical research problems. The final day of the workshop was devoted to an open discussion on the research directions that could be anticipated in the next decade because of new and planned instrumentation and observational networks, the recent emphasis on development of mesoscale numerical models, and continual theoretical investigations of thermally forced flows, orographic waves, and stratified turbulence. This monograph represents an outgrowth of the Park City Workshop. The authors have contributed chapters based on their lecture material. Workshop discussions indicated interest in both the remote sensing and predictability of orographic flows. These chapters were solicited following the workshop in order to provide a more balanced view of current progress and future directions in research on atmospheric processes over complex terrain.

On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis.

PubMed

Blasco-Gómez, Ramiro; Batlle-Vilanova, Pau; Villano, Marianna; Balaguer, Maria Dolors; Colprim, Jesús; Puig, Sebastià

2017-04-20

The conversion of electrical current into methane (electromethanogenesis) by microbes represents one of the most promising applications of bioelectrochemical systems (BES). Electromethanogenesis provides a novel approach to waste treatment, carbon dioxide fixation and renewable energy storage into a chemically stable compound, such as methane. This has become an important area of research since it was first described, attracting different research groups worldwide. Basics of the process such as microorganisms involved and main reactions are now much better understood, and recent advances in BES configuration and electrode materials in lab-scale enhance the interest in this technology. However, there are still some gaps that need to be filled to move towards its application. Side reactions or scaling-up issues are clearly among the main challenges that need to be overcome to its further development. This review summarizes the recent advances made in the field of electromethanogenesis to address the main future challenges and opportunities of this novel process. In addition, the present fundamental knowledge is critically reviewed and some insights are provided to identify potential niche applications and help researchers to overcome current technological boundaries.

[Male contraception - the current state of knowledge].

PubMed

Zdrojewicz, Zygmynt; Kasperska, Karolina; Lewandowska, Marta

2016-08-01

Contraception is important from a health, psychological and socioeconomic point of view. Due to the fact that male-based contraceptive methods are mostly represented by condoms and vasectomy, researchers are working on the new solutions, which could let the men be more involved in a conscious family planning. In this review we will present the current state of knowledge on this subject. There is a lot going on in the field of hormonal contraception. Studies including testosterone, progestins, synthetic androgens and other derivatives are on a different stages of clinical trials and mostly demonstrate high efficacy rates. Recent discovers of Izumo and Juno proteins, essential for the fertilization process, give hope for an easily reversible, non-hormonal method. Researchers are also trying to interfere with the process of spermatogenesis using BRDT inhibitor - JQ1, or neutralize the sperm by injecting styrene maleic anhydride (SMA) into the lumen of the vas deferens. The other studies explore processes involved in proper sperm motility. A vaccine which induces an immune response to the reproductive system is also an interesting method. The latest research use ultrasound waves and mechanical device which blocks the patency of vas deferens. The aim of the study current state of knowledge male contraception. © 2016 MEDPRESS.

Nano-food packaging: an overview of market, migration research, and safety regulations.

PubMed

Bumbudsanpharoke, Nattinee; Ko, Seonghyuk

2015-05-01

Recently, food packages produced with nanoparticles, "nano-food packaging," have become more available in the current market. However, although the use of nanomaterials is increasing in food packaging applications, concern over toxicity affects consumer perceptions and acceptance. Quite a number of commercialized forms of nano-food packaging are coated or composited product with inorganic materials, for example, nanosilver and nanoclay as representative examples. Several studies have shown the possibility of nanomaterial migration from packaging or containers to foodstuff. The debate is still ongoing among researchers about the extent of migration and whether it is negligible and safe. Government agencies and stakeholders must hurry to determine use limitations and release conclusive legislation and regulations as soon as possible since nano-food packaging may have great impacts on human health. This paper aims to review the availability of nano-food packaging in the current market, report case studies on nanomaterial migration, and present the current status of safety regulations and management of nano-food packaging in leading countries across regions. This review should enable governments and researchers to develop further nanomaterial risk assessment studies. © 2015 Institute of Food Technologists®

Distribution of excess temperature from the Morgantown Generating Station on the Potomac Estuary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, H.H.

1973-10-01

Research undertaken to determine the effects of thermal effluents on the temperature distribution in estuarine waters is described. Procedures for and results from measurements of the temperature, river flow, tidal currents, salinity, wind, etc at the Potomac River estuary in 1969 and 1972, which represent pre- and post-operation conditions for the operation of the fossil- fueled Morgantown power plant, are reported. (LC L)

Flutter Research on Skin Panels

NASA Technical Reports Server (NTRS)

Kordes, Eldon E.; Tuovila, Weimer J.; Guy, Lawrence D.

1960-01-01

Representative experimental results are presented to show the current status of the panel flutter problem. Results are presented for unstiffened rectangular panels and for rectangular panels stiffened by corrugated backing. Flutter boundaries are established for all types of panels when considered on the basis of equivalent isotropic plates. The effects of Mach number, differential pressure, and aerodynamic heating on panel flutter are discussed. A flutter analysis of orthotropic panels is presented in the appendix.

Centrifugal Blower for Personal Air Ventilation System (PAVS) - Phase 1

DTIC Science & Technology

2015-02-01

and rechargeable Li- ion . This battery analysis uses just the cells available from one manufacturer, but is representative of what is available in...13. SUPPLEMENTARY NOTES SBIR data rights period expired November 23, 2012. 14. ABSTRACT Report Developed under Small Business Innovation Research...that the electrical power input was under 15 W. The motor voltage and current were matched with standard military battery cells of various

National Commission on Student Financial Assistance. Hearing before the Subcommittee on Postsecondary Education of the Committee on Education and Labor. House of Representatives, Ninety-Eighth Congress, First Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

Hearings concerning research done for the National Commission on Student Financial Assistance are presented, along with the Commission's recommendations. The recommendations concern modifications of the current law to facilitate greater access for low- and middle-income students and to improve the quality of postsecondary education in the country.…

The Effects of Early Social-Emotional and Relationship Experience on the Development of Young Orphanage Children: The St. Petersburg-USA Orphanage Research Team

ERIC Educational Resources Information Center

Monographs of the Society for Research in Child Development, 2008

2008-01-01

This study represents a quasi-experimental test of the role of early social-emotional experience and adult-child relationships in the development of typically developing children and those with disabilities birth to 4 years of age living in orphanages in St. Petersburg, Russian Federation. The three orphanages in the current study were selected…

Prevention Strategies for Healthy Babies and Healthy Children. Hearing before the Select Committee on Children, Youth, and Families. House of Representatives, Ninety-Eighth Congress, First Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

Testimony presented in this document covers (1) current initiatives in the Public Health Service agenda to promote and protect the health of mothers and infants and to implement specific prevention activities in child health; (2) key issues in outcome and prevention along the human growth line; (3) recent neuroscience research having implications…

Threats and knowledge gaps for ecosystem services provided by kelp forests: a northeast Atlantic perspective

PubMed Central

Smale, Dan A; Burrows, Michael T; Moore, Pippa; O'Connor, Nessa; Hawkins, Stephen J

2013-01-01

Kelp forests along temperate and polar coastlines represent some of most diverse and productive habitats on the Earth. Here, we synthesize information from >60 years of research on the structure and functioning of kelp forest habitats in European waters, with particular emphasis on the coasts of UK and Ireland, which represents an important biogeographic transition zone that is subjected to multiple threats and stressors. We collated existing data on kelp distribution and abundance and reanalyzed these data to describe the structure of kelp forests along a spatial gradient spanning more than 10° of latitude. We then examined ecological goods and services provided by kelp forests, including elevated secondary production, nutrient cycling, energy capture and flow, coastal defense, direct applications, and biodiversity repositories, before discussing current and future threats posed to kelp forests and identifying key knowledge gaps. Recent evidence unequivocally demonstrates that the structure of kelp forests in the NE Atlantic is changing in response to climate- and non-climate-related stressors, which will have major implications for the structure and functioning of coastal ecosystems. However, kelp-dominated habitats along much of the NE Atlantic coastline have been chronically understudied over recent decades in comparison with other regions such as Australasia and North America. The paucity of field-based research currently impedes our ability to conserve and manage these important ecosystems. Targeted observational and experimental research conducted over large spatial and temporal scales is urgently needed to address these knowledge gaps. PMID:24198956

Threats and knowledge gaps for ecosystem services provided by kelp forests: a northeast Atlantic perspective.

PubMed

Smale, Dan A; Burrows, Michael T; Moore, Pippa; O'Connor, Nessa; Hawkins, Stephen J

2013-10-01

Kelp forests along temperate and polar coastlines represent some of most diverse and productive habitats on the Earth. Here, we synthesize information from >60 years of research on the structure and functioning of kelp forest habitats in European waters, with particular emphasis on the coasts of UK and Ireland, which represents an important biogeographic transition zone that is subjected to multiple threats and stressors. We collated existing data on kelp distribution and abundance and reanalyzed these data to describe the structure of kelp forests along a spatial gradient spanning more than 10° of latitude. We then examined ecological goods and services provided by kelp forests, including elevated secondary production, nutrient cycling, energy capture and flow, coastal defense, direct applications, and biodiversity repositories, before discussing current and future threats posed to kelp forests and identifying key knowledge gaps. Recent evidence unequivocally demonstrates that the structure of kelp forests in the NE Atlantic is changing in response to climate- and non-climate-related stressors, which will have major implications for the structure and functioning of coastal ecosystems. However, kelp-dominated habitats along much of the NE Atlantic coastline have been chronically understudied over recent decades in comparison with other regions such as Australasia and North America. The paucity of field-based research currently impedes our ability to conserve and manage these important ecosystems. Targeted observational and experimental research conducted over large spatial and temporal scales is urgently needed to address these knowledge gaps.

Health care reform 2010: a fresh view on tort reform.

PubMed

Stimson, C J; Dmochowski, Roger; Penson, David F

2010-11-01

We reviewed the state of medical malpractice tort reform in the context of a new political climate and the current debate over comprehensive health care reform. Specifically we asked whether medical malpractice tort reform is necessary, and evaluated the strengths and weaknesses of contemporary reform proposals. The medical, legal and public policy literature related to medical malpractice tort reform was reviewed and synthesized. We include a primer for understanding the current structure of medical malpractice law, identify the goals of the current system and analyze whether these goals are presently being met. Finally, we describe and evaluate the strengths and weaknesses of the current reform proposals including caps on damages, safe harbors and health care courts. Medical malpractice tort law is designed to improve health care quality and appropriately compensate patients for medical malpractice injuries, but is failing on both fronts. Of the 3 proposed remedies, caps on damages do little to advance the quality and compensatory goals, while safe harbors and health care courts represent important advancements in tort reform. Tort reform should be included in the current health policy debate because the current medical malpractice system is not adequately achieving the basic goals of tort law. While safe harbors and health care courts both represent reasonable remedies, health care courts may be preferred because they do not rely on jury determination in the absence of strong medical evidence. Copyright © 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Re-Creation of Historical Chrysotile-Containing Joint Compounds

PubMed Central

Brorby, G. P.; Sheehan, P. J.; Berman, D. W.; Greene, J. F.; Holm, S. E.

2008-01-01

Chrysotile-containing joint compound was commonly used in construction of residential and commercial buildings through the mid 1970s; however, these products have not been manufactured in the United States for more than 30 years. Little is known about actual human exposures to chrysotile fibers that may have resulted from use of chrysotile-containing joint compounds, because few exposure and no health-effects studies have been conducted specifically with these products. Because limited amounts of historical joint compounds are available (and the stability or representativeness of aged products is suspect), it is currently impossible to conduct meaningful studies to better understand the nature and magnitude of potential exposures to chrysotile that may have been associated with historical use of these products. Therefore, to support specific exposure and toxicology research activities, two types of chrysotile-containing joint compounds were produced according to original formulations from the late 1960s. To the extent possible, ingredients were the same as those used originally, with many obtained from the original suppliers. The chrysotile used historically in these products was primarily Grade 7RF9 from the Philip Carey mine. Because this mine is closed, a suitable alternate was identified by comparing the sizes and mineral composition of asbestos structures in a sample of what has been represented to be historical joint compound (all of which were chrysotile) to those in samples of three currently commercially available Grade 7 chrysotile products. The re-created materials generally conformed to original product specifications (e.g. viscosity, workability, crack resistance), indicating that these materials are sufficiently representative of the original products to support research activities. PMID:18788019

Toxins produced in cyanobacterial water blooms – toxicity and risks

PubMed Central

Bláha, Luděk; Babica, Pavel; Maršálek, Blahoslav

2009-01-01

Cyanobacterial blooms in freshwaters represent a major ecological and human health problem worldwide. This paper briefly summarizes information on major cyanobacterial toxins (hepatotoxins, neurotoxins etc.) with special attention to microcystins-cyclic heptapeptides with high acute and chronic toxicities. Besides discussion of human health risks, microcystin ecotoxicology and consequent ecological risks are also highlighted. Although significant research attention has been paid to microcystins, cyanobacteria produce a wide range of currently unknown toxins, which will require research attention. Further research should also address possible additive, synergistic or antagonistic effects among different classes of cyanobacterial metabolites, as well as interactions with other toxic stressors such as metals or persistent organic pollutants. PMID:21217843

Icing Test Results on an Advanced Two-Dimensional High-Lift Multi-Element Airfoil

NASA Technical Reports Server (NTRS)

Shin, Jaiwon; Wilcox, Peter; Chin, Vincent; Sheldon, David

1994-01-01

An experimental study has been conducted to investigate ice accretions on a high-lift, multi-element airfoil in the Icing Research Tunnel at the NASA Lewis Research Center. The airfoil is representative of an advanced transport wing design. The experimental work was conducted as part of a cooperative program between McDonnell Douglas Aerospace and the NASA Lewis Research Center to improve current understanding of ice accretion characteristics on the multi-element airfoil. The experimental effort also provided ice shapes for future aerodynamic tests at flight Reynolds numbers to ascertain high-lift performance effects. Ice shapes documented for a landing configuration over a variety of icing conditions are presented along with analyses.

The emerging role of lidar remote sensing in coastal research and resource management

USGS Publications Warehouse

Brock, J.C.; Purkis, S.J.

2009-01-01

Knowledge of coastal elevation is an essential requirement for resource management and scientific research. Recognizing the vast potential of lidar remote sensing in coastal studies, this Special Issue includes a collection of articles intended to represent the state-of-the-art for lidar investigations of nearshore submerged and emergent ecosystems, coastal morphodynamics, and hazards due to sea-level rise and severe storms. Some current applications for lidar remote sensing described in this Special Issue include bluegreen wavelength lidar used for submarine coastal benthic environments such as coral reef ecosystems, airborne lidar used for shoreline mapping and coastal change detection, and temporal waveform-resolving lidar used for vegetation mapping. ?? 2009 Coastal Education and Research Foundation.

Contribution of Spaceflight Environmental Factors to Vision Risks

NASA Technical Reports Server (NTRS)

Zanello, Susana

2012-01-01

The recognition of a risk of visual impairment and intracranial pressure increase as a result of spaceflight has directed our attention and research efforts to the eye. While the alterations observed in astronauts returning from long duration missions include reportable vision and neuroanatomical changes observed by non-invasive methods, other effects and subsequent tissue responses at the molecular and cellular level can only be studied by accessing the tissue itself. As a result of this need, several studies are currently taking place that use animal models for eye research within the HHC Element. The implementation of these studies represents a significant addition to the capabilities of the biomedical research laboratories within the SK3 branch at JSC.

Research Driven Policy: Is Financial Capacity Related to Dangerousness?

PubMed

DeLeon, Patrick H; Paxton, Maegan M; Spencer, Tonya; Bajjani-Gebara, Jouhayna E

2018-05-22

Current Veterans administration policy directly links a Veteran's adjudged capacity to manage personal financial resources with their ability to purchase or possess a firearm, pursuant to the regulatory authority of the National Instant Criminal Background Check System (NICS). Preventing Veterans' suicide is a highly laudable public health objective. Effectively utilizing scientific research to "inform" public policy is equally important. The authors should be congratulated for their efforts. However, it is important in utilizing large set population-based data, especially social science data, to evaluate policy alternatives that there be substantial face (i.e., clinical) validity. Correlation does not necessarily represent causation.

The Role of Internet Engagement in the Health-knowledge Gap

PubMed Central

Lee, Chul-joo

2014-01-01

The current research posits that education leads to differential levels of Internet engagement, which moderate the association between Internet use for health information and general health knowledge. Using a nationally representative survey that covers adults between the ages of 40 and 70 in the United States, it is found that education is positively related to Internet engagement. Also, Internet use has stronger associations with health knowledge for people exhibiting high Internet engagement than for people exhibiting low Internet engagement. The implications of these findings for research on both Internet use and knowledge gaps are discussed. PMID:25530667

Proceedings of the Ocean Energy Information Dissemination Workshop

NASA Astrophysics Data System (ADS)

Petty, D.

1980-04-01

The workshop was held to discuss the status of marketing ocean energy information and to develop an understanding of information needs and how to satisfy them. Presentations were made by the Solar Energy Research Institute (SERI) staff and media consultants about the effective use of audio visual and print products, the mass media, and audience needs. Industry and government representatives reported on current efforts in each of their communication programs and outlined future plans. Four target audiences (DOE contractors, researchers, influencers, and general public) were discussed with respect to developing priorities for projects to enhance the commercialization of ocean energy technology.

Dynamic field theory and executive functions: lending explanation to current theories of development.

PubMed

Morton, J Bruce

2014-06-01

Buss and Spencer's monograph is an impressive achievement that is sure to have a lasting impact on the field of child development. The dynamic field theory (DFT) model that forms the heart of this contribution is ambitious in scope, detailed in its implementation, and rigorously tested against data, old and new. As such, the ideas contained in this fine document represent a qualitative advance in our understanding of young children's behavior, and lay a foundation for future research into the developmental origins of executive functioning. © 2014 The Society for Research in Child Development, Inc.

Improving poverty and inequality modelling in climate research

NASA Astrophysics Data System (ADS)

Rao, Narasimha D.; van Ruijven, Bas J.; Riahi, Keywan; Bosetti, Valentina

2017-12-01

As climate change progresses, the risk of adverse impacts on vulnerable populations is growing. As governments seek increased and drastic action, policymakers are likely to seek quantification of climate-change impacts and the consequences of mitigation policies on these populations. Current models used in climate research have a limited ability to represent the poor and vulnerable, or the different dimensions along which they face these risks. Best practices need to be adopted more widely, and new model features that incorporate social heterogeneity and different policy mechanisms need to be developed. Increased collaboration between modellers, economists, and other social scientists could aid these developments.

Technology transfer in the NASA Ames Advanced Life Support Division

NASA Technical Reports Server (NTRS)

Connell, Kathleen; Schlater, Nelson; Bilardo, Vincent; Masson, Paul

1992-01-01

This paper summarizes a representative set of technology transfer activities which are currently underway in the Advanced Life Support Division of the Ames Research Center. Five specific NASA-funded research or technology development projects are synopsized that are resulting in transfer of technology in one or more of four main 'arenas:' (1) intra-NASA, (2) intra-Federal, (3) NASA - aerospace industry, and (4) aerospace industry - broader economy. Each project is summarized as a case history, specific issues are identified, and recommendations are formulated based on the lessons learned as a result of each project.

Physical Samples Linked Data in Action

NASA Astrophysics Data System (ADS)

Ji, P.; Arko, R. A.; Lehnert, K.; Bristol, S.

2017-12-01

Most data and metadata related to physical samples currently reside in isolated relational databases driven by diverse data models. How to approach the challenge for sharing, interchanging and integrating data from these difference relational databases motivated us to publish Linked Open Data for collections of physical samples, using Semantic Web technologies including the Resource Description Framework (RDF), RDF Query Language (SPARQL), and Web Ontology Language (OWL). In last few years, we have released four knowledge graphs concentrated on physical samples, including System for Earth Sample Registration (SESAR), USGS National Geochemical Database (NGDC), Ocean Biogeographic Information System (OBIS), and Earthchem Database. Currently the four knowledge graphs contain over 12 million facets (triples) about objects of interest to the geoscience domain. Choosing appropriate domain ontologies for representing context of data is the core of the whole work. Geolink ontology developed by Earthcube Geolink project was used as top level to represent common concepts like person, organization, cruise, etc. Physical sample ontology developed by Interdisciplinary Earth Data Alliance (IEDA) and Darwin Core vocabulary were used as second level to describe details about geological samples and biological diversity. We also focused on finding and building best tool chains to support the whole life cycle of publishing linked data we have, including information retrieval, linked data browsing and data visualization. Currently, Morph, Virtuoso Server, LodView, LodLive, and YASGUI were employed for converting, storing, representing, and querying data in a knowledge base (RDF triplestore). Persistent digital identifier is another main point we concentrated on. Open Researcher & Contributor IDs (ORCIDs), International Geo Sample Numbers (IGSNs), Global Research Identifier Database (GRID) and other persistent identifiers were used to link different resources from various graphs with person, sample, organization, cruise, etc. This work is supported by the EarthCube "GeoLink" project (NSF# ICER14-40221 and others) and the "USGS-IEDA Partnership to Support a Data Lifecycle Framework and Tools" project (USGS# G13AC00381).

NHLBI workshop: respiratory medicine-related research training for adult and pediatric fellows.

PubMed

Choi, Augustine M K; Reynolds, Herbert Y; Colombini-Hatch, Sandra; Rothgeb, Ann; Blaisdell, Carol J; Gail, Dorothy B

2009-01-01

The pulmonary physician-scientist has a special niche to generate basic research findings and apply them to a clinical disease and perhaps impact its medical care. The availability of new high throughput-based scientific technologies in the "omics era" has made this an opportune time for physician scientists to prepare and embark on an academic career in respiratory disease research. However, maintaining an adequate flow through the research pipeline of physician-scientist investigators studying respiratory system diseases is currently a challenge. There may not be a sufficient workforce emerging to capitalize on current research opportunities. The National Heart, Lung, and Blood Institute (NHLBI) organized a workshop to assess ways to attract and properly train advanced fellows to pursue research careers in adult and pediatric lung diseases. Participants included representatives from the various pulmonary training programs, respiratory-related professional societies, and NHLBI staff. Deliberation centered on present barriers that might affect interest in pursuing research training, devising better incentives to attract more trainees, and how current research support offered by the NHLBI and the Professional Societies (in partnership with Industry and Patient Support groups) might be better coordinated and optimized to ensure a continued pipeline of pulmonary investigators. Major recommendations offered are: (1) Attract trainees to pulmonary/critical care medicine-based research careers by increasing research exposure and opportunities for high school, college, and medical students. (2) Increase awareness of the outstanding physician-scientist role models in the lung community for trainees. (3) Facilitate mechanisms by which the lung community (NHLBI, professional societies, and partners) can better support and bridge senior fellows as they transition from Institutional Training Grants (T32) to Career Series (K) awards in their early faculty career development.

Ethical issues and best practice in clinically based genomic research: Exeter Stakeholders Meeting Report.

PubMed

Carrieri, D; Bewshea, C; Walker, G; Ahmad, T; Bowen, W; Hall, A; Kelly, S

2016-09-27

Current guidelines on consenting individuals to participate in genomic research are diverse. This creates problems for participants and also for researchers, particularly for clinicians who provide both clinical care and research to their patients. A group of 14 stakeholders met on 7 October 2015 in Exeter to discuss the ethical issues and the best practice arising in clinically based genomic research, with particular emphasis on the issue of returning results to study participants/patients in light of research findings affecting research and clinical practices. The group was deliberately multidisciplinary to ensure that a diversity of views was represented. This report outlines the main ethical issues, areas of best practice and principles underlying ethical clinically based genomic research discussed during the meeting. The main point emerging from the discussion is that ethical principles, rather than being formulaic, should guide researchers/clinicians to identify who the main stakeholders are to consult with for a specific project and to incorporate their voices/views strategically throughout the lifecycle of each project. We believe that the mix of principles and practical guidelines outlined in this report can contribute to current debates on how to conduct ethical clinically based genomic research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Use of Nonhuman Primates in Research in North America

PubMed Central

Turner, Patricia V; Mullan, Robert J; Galland, G Gale

2014-01-01

In North America, the biomedical research community faces social and economic challenges to nonhuman primate (NHP) importation that could reduce the number of NHP available for research needs. The effect of such limitations on specific biomedical research topics is unknown. The Association of Primate Veterinarians (APV), with assistance from the Centers for Disease Control and Prevention, developed a survey regarding biomedical research involving NHP in the United States and Canada. The survey sought to determine the number and species of NHP maintained at APV members’ facilities, current uses of NHP to identify the types of biomedical research that rely on imported animals, and members’ perceived trends in NHP research. Of the 149 members contacted, 33 (22%) replied, representing diverse facility sizes and types. Cynomolgus and rhesus macaques were the most common species housed at responding institutions and comprised the majority of newly acquired and imported NHP. The most common uses for NHP included pharmaceutical research and development and neuroscience, neurology, or neuromuscular disease research. Preclinical safety testing and cancer research projects usually involved imported NHP, whereas research on aging or degenerative disease, reproduction or reproductive disease, and organ or tissue transplantation typically used domestic-bred NHP. The current results improve our understanding of the research uses for imported NHP in North America and may facilitate estimating the potential effect of any future changes in NHP accessibility for research purposes. Ensuring that sufficient NHP are available for critical biomedical research remains a pressing concern for the biomedical research community in North America. PMID:24827570

Single-entry models (SEMs) for scheduled services: Towards a roadmap for the implementation of recommended practices.

PubMed

Lopatina, Elena; Damani, Zaheed; Bohm, Eric; Noseworthy, Tom W; Conner-Spady, Barbara; MacKean, Gail; Simpson, Chris S; Marshall, Deborah A

2017-09-01

Long waiting times for elective services continue to be a challenging issue. Single-entry models (SEMs) are used to increase access to and flow through the healthcare system. This paper provides a roadmap for healthcare decision-makers, managers, physicians, and researchers to guide implementation and management of successful and sustainable SEMs. The roadmap was informed by an inductive qualitative synthesis of the findings from a deliberative process (a symposium on SEMs, with clinicians, researchers, senior policy-makers, healthcare managers, and patient representatives) and focus groups with the symposium participants. SEMs are a promising strategy to improve the management of referrals and represent one approach to reduce waiting times. The SEMs roadmap outlines current knowledge about SEMs and critical success factors for SEMs' implementation and management. This SEM roadmap is intended to help clinicians, decision-makers, managers, and researchers interested in developing new or strengthening existing SEMs. We consider this roadmap to be a living document that will continue to evolve as we learn more about implementing and managing sustainable SEMs. Copyright © 2017 Elsevier B.V. All rights reserved.

Government funding of health research in New Zealand.

PubMed

Reid, Ian R; Joyce, Peter; Fraser, John; Crampton, Peter

2014-02-14

An analysis of levels of government health research funding carried out in 2008 demonstrated that funding in New Zealand, after adjustment for population size, was less than one-third of that in Australia, less than one-fifth of that in the United Kingdom, and about 10% of that in the United States. This was perceived to be a major obstacle to the recruitment and retention of clinical and academic staff in our hospitals and universities. We have now repeated these analyses to determine the current state of these comparisons. From 2009 to the present funds for direct funding of research through the Health Research Council (HRC) have remained static at $54m. As a result of inflation of research costs (principally salaries) this represents a decrease of approximately one-quarter in the quantum of research funded by the HRC over the last 4 years. Current funding rates in the comparator countries, population-adjusted and converted to NZ$, are 3.4-fold higher in Australia, 4.5-fold higher in the United Kingdom, and 9.7-fold higher in the United States. Urgent and sustained action is needed to correct these major disparities in government health research funding if the quality of academic and clinical staff in our public institutions is to be maintained.

Computed Tomography to Estimate the Representative Elementary Area for Soil Porosity Measurements

PubMed Central

Borges, Jaqueline Aparecida Ribaski; Pires, Luiz Fernando; Belmont Pereira, André

2012-01-01

Computed tomography (CT) is a technique that provides images of different solid and porous materials. CT could be an ideal tool to study representative sizes of soil samples because of the noninvasive characteristic of this technique. The scrutiny of such representative elementary sizes (RESs) has been the target of attention of many researchers related to soil physics field owing to the strong relationship between physical properties and size of the soil sample. In the current work, data from gamma-ray CT were used to assess RES in measurements of soil porosity (ϕ). For statistical analysis, a study on the full width at a half maximum (FWHM) of the adjustment of distribution of ϕ at different areas (1.2 to 1162.8 mm2) selected inside of tomographic images was proposed herein. The results obtained point out that samples with a section area corresponding to at least 882.1 mm2 were the ones that provided representative values of ϕ for the studied Brazilian tropical soil. PMID:22666133

Discussing Opioid Risks With Patients to Reduce Misuse and Abuse: Evidence From 2 Surveys

PubMed Central

Hero, Joachim O.; McMurtry, Caitlin; Benson, John; Blendon, Robert

2016-01-01

We used 2 population-representative surveys to evaluate the recommendation from recent clinical guidelines for prescribing opioid analgesics that physicians discuss the risk of long-term use disorders with patients. In nationally representative data we observed a 60% lower rate, after adjustment for covariates, in a self-reported saving of pills among respondents who say they talked with their physicians about the risks of prescription painkiller addiction (67% lower rate without adjustment). These findings suggest patient education efforts, as currently practiced in the United States, may have positive behavioral consequences that could lower the risks of prescription painkiller abuse. Future research should test these associations under controlled settings. PMID:28376444

Wind shear detection. Forward-looking sensor technology

NASA Technical Reports Server (NTRS)

Bracalente, E. M. (Compiler); Delnore, V. E. (Compiler)

1987-01-01

A meeting took place at NASA Langley Research Center in February 1987 to discuss the development and eventual use of forward-looking remote sensors for the detection and avoidance of wind shear by aircraft. The participants represented industry, academia, and government. The meeting was structured to provide first a review of the current FAA and NASA wind shear programs, then to define what really happens to the airplane, and finally to give technology updates on the various types of forward-looking sensors. This document is intended to informally record the essence of the technology updates (represented here through unedited duplication of the vugraphs used), and the floor discussion following each presentation. Also given are key issues remaining unresolved.

2002 Microgravity Materials Science Conference

NASA Technical Reports Server (NTRS)

Gillies, Donald (Editor); Ramachandran, Narayanan (Editor); Murphy, Karen (Editor); McCauley, Dannah (Editor); Bennett, Nancy (Editor)

2003-01-01

The 2002 Microgravity Materials Science Conference was held June 25-26, 2002, at the Von Braun Center, Huntsville, Alabama. Organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Physical Sciences Research Division, NASA Headquarters, and hosted by NASA Marshall Space Flight Center and member institutions under the Cooperative Research in Biology and Materials Science (CORBAMS) agreement, the conference provided a forum to review the current research and activities in materials science, discuss the envisioned long-term goals, highlight new crosscutting research areas of particular interest to the Physical Sciences Research Division, and inform the materials science community of research opportunities in reduced gravity. An abstracts book was published and distributed at the conference to the approximately 240 people attending, who represented industry, academia, and other NASA Centers. This CD-ROM proceedings is comprised of the research reports submitted by the Principal Investigators in the Microgravity Materials Science program.

Expected net present value of sample information: from burden to investment.

PubMed

Hall, Peter S; Edlin, Richard; Kharroubi, Samer; Gregory, Walter; McCabe, Christopher

2012-01-01

The Expected Value of Information Framework has been proposed as a method for identifying when health care technologies should be immediately reimbursed and when any reimbursement should be withheld while awaiting more evidence. This framework assesses the value of obtaining additional evidence to inform a current reimbursement decision. This represents the burden of not having the additional evidence at the time of the decision. However, when deciding whether to reimburse now or await more evidence, decision makers need to know the value of investing in more research to inform a future decision. Assessing this value requires consideration of research costs, research time, and what happens to patients while the research is undertaken and after completion. The investigators describe a development of the calculation of the expected value of sample information that assesses the value of investing in further research, including an only-in-research strategy and an only-with-research strategy.

What proportion of people who try one cigarette become daily smokers? A meta analysis of representative surveys.

PubMed

Birge, Max; Duffy, Stephen; Miler, Joanna Astrid; Hajek, Peter

2017-11-04

The 'conversion rate' from initial experimentation to daily smoking is a potentially important metric of smoking behavior, but estimates of it based on current representative data are lacking. The Global Health Data Exchange was searched for representative surveys conducted in English speaking, developed countries after year 2000 that included questions about ever trying a cigarette and ever smoking daily. The initial search identified 2776 surveys that were further screened for language, location, year, sample size, survey structure and representativeness. 44 surveys that passed the screening process were accessed and their codebooks were examined to see whether the two questions of interest were included. Eight datasets allowed extraction or estimation of relevant information. Survey quality was assessed with regards to response rates, sampling methods and data collection procedures. PRISMA guidelines were followed, with explicit rules for approaching derived variables and skip patterns. Proportions were pooled using random effects meta-analysis. The eight surveys used representative samples of the general adult population. Response rates varied from 45% to 88%. Survey methods were on par with the best practice in this field. Altogether 216,314 respondents were included of whom 60.3% (95%CI 51.3-69.3) ever tried a cigarette. Among those, 68.9% (95% CI 60.9-76.9%) progressed to daily smoking. Over two thirds of people who try one cigarette become, at least temporarily, daily smokers. The finding provides strong support for the current efforts to reduce cigarette experimentation among adolescents. The transition from trying the first cigarette through occasional to daily smoking usually implies that a recreational activity is turning into a compulsive need that has to be satisfied virtually continuously. The 'conversion rate' from initial experimentation to daily smoking is thus a potentially important metric of smoking behavior, but estimates of it based on representative data are lacking. The present meta analysis addressed this gap. Currently, about two thirds of non-smokers experimenting with cigarettes progress to daily smoking. The finding supports strongly the current efforts to reduce cigarette experimentation among adolescents. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Antibacterial Discovery and Development: From Gene to Product and Back

PubMed Central

Fedorenko, Victor; Genilloud, Olga; Horbal, Liliya; Marcone, Giorgia Letizia; Marinelli, Flavia; Paitan, Yossi; Ron, Eliora Z.

2015-01-01

Concern over the reports of antibiotic-resistant bacterial infections in hospitals and in the community has been publicized in the media, accompanied by comments on the risk that we may soon run out of antibiotics as a way to control infectious disease. Infections caused by Enterococcus faecium, Staphylococcus aureus, Klebsiella species, Clostridium difficile, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and other Enterobacteriaceae species represent a major public health burden. Despite the pharmaceutical sector's lack of interest in the topic in the last decade, microbial natural products continue to represent one of the most interesting sources for discovering and developing novel antibacterials. Research in microbial natural product screening and development is currently benefiting from progress that has been made in other related fields (microbial ecology, analytical chemistry, genomics, molecular biology, and synthetic biology). In this paper, we review how novel and classical approaches can be integrated in the current processes for microbial product screening, fermentation, and strain improvement. PMID:26339625

Highlights of recent balance of system research and evaluation

NASA Astrophysics Data System (ADS)

Thomas, M. G.; Stevens, J. W.

The cost of most photovoltaic (PV) systems is more a function of the balance of system (BOS) components than the collectors. The exception to this rule is the grid-tied system whose cost is related more directly to the collectors, and secondarily to the inverter/controls. In fact, recent procurements throughout the country document that collector costs for roof-mounted, utility-tied systems (Russell, PV Systems Workshop, 7/94) represent 60% to 70% of the system cost. This contrasts with the current market for packaged stand-alone all PV or PV-hybrid systems where collectors represent only 25% to 35% of the total. Not only are the BOS components the cost drivers in the current cost-effective PV system market place, they are also the least reliable components. This paper discusses the impact that BOS issues have on component performance, system performance, and system cost and reliability. We will also look at recent recommended changes in system design based upon performance evaluations of fielded PV systems.

Genetics and epigenetics of rheumatoid arthritis

PubMed Central

Viatte, Sebastien; Plant, Darren; Raychaudhuri, Soumya

2013-01-01

Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10 years. Although genetic studies have had limited influence on clinical practice and drug discovery, they are currently generating testable hypotheses to explain disease pathogenesis. Firstly, we review here the major advances in identifying RA genetic susceptibility markers both within and outside of the MHC. Understanding how genetic variants translate into pathogenic mechanisms and ultimately into phenotypes remains a mystery for most of the polymorphisms that confer susceptibility to RA, but functional data are emerging. Interplay between environmental and genetic factors is poorly understood and in need of further investigation. Secondly, we review current knowledge of the role of epigenetics in RA susceptibility. Differences in the epigenome could represent one of the ways in which environmental exposures translate into phenotypic outcomes. The best understood epigenetic phenomena include post-translational histone modifications and DNA methylation events, both of which have critical roles in gene regulation. Epigenetic studies in RA represent a new area of research with the potential to answer unsolved questions. PMID:23381558

Longitudinal Predictors of Homelessness: Findings from the National Longitudinal Survey of Youth-97

PubMed Central

Sznajder-Murray, Brittany; Jang, Joy Bohyun; Slesnick, Natasha; Snyder, Anastasia

2016-01-01

Homeless youth represent a vulnerable and understudied population. Little research has prospectively identified factors that may place youth at risk for experiencing homelessness. The current study utilizes data from the National Longitudinal Survey of Youth-97 (NLSY-97) to examine predictors of experiencing homelessness as a young adult (before age 25). The NLSY-97 includes a nationally representative sample of 8,984 youth. Data were first collected from these youth when they were between the ages of 12 to 18 years. The current study examined whether individual and family risk factors reported during adolescence predict homelessness by the age of 25. The findings showed that multiple runaway episodes, non-traditional family structure, lower educational attainment, and parental work limitations due to health increased the risk of homelessness. A permissive parenting style and being Hispanic protected against homelessness. This study offers unique insight into risk and protective factors for youth homelessness, and has important clinical implications. PMID:27774034

Oxygen tension in embryo culture: does a shift to 2% O2 in extended culture represent the most physiologic system?

PubMed

Morin, Scott J

2017-03-01

There has been much debate regarding the optimal oxygen tension in clinical embryo culture. The majority of the literature to date has compared 5% oxygen to atmospheric levels (20-21%). While the majority of modern IVF labs have accepted the superiority of 5% oxygen tension, a new debate has emerged regarding whether a further reduction after day 3 of development represents the most physiologic system. This new avenue of research is based on the premise that oxygen tension is in fact lower in the uterus than in the oviduct and that the embryo crosses the uterotubal junction sometime on day 3. While data are currently limited, recent experience with ultra-low oxygen (2%) after day 3 of development suggests that the optimal oxygen tension in embryo culture may depend on the stage of development. This review article will consider the current state of the literature and discuss ongoing efforts at studying ultra-low oxygen tension in extended culture.

The EOS land validation core sites: background information and current status

USGS Publications Warehouse

Morisette, J.; Privette, J.L.; Justice, C.; Olson, D.; Dwyer, John L.; Davis, P.; Starr, D.; Wickland, D.

1999-01-01

The EOS Land Validation Core Sites1 will provide the user community with timely ground, aircraft, and satellite data for EOS science and validation investigations. The sites, currently 24 distributed worldwide, represent a consensus among the instrument teams and validation investigators and represent a range of global biome types (see Figure 1 and Table 1; Privette et al., 1999; Justice et al., 1998). The sites typically have a history of in situ and remote observations and can expect continued monitoring and land cover research activities. In many cases, a Core Site will have a tower equipped with above-canopy instrumentation for nearcontinuous sampling of landscape radiometric, energy and CO2 flux, meteorological variables, and atmospheric aerosol and water vapor data. These will be complemented by intensive field measurement campaigns. The data collected at these sites will provide an important resource for the broader science community. These sites can also provide a foundation for a validation network supported and used by all international space agencies.

The ethics of HIV "cure" research: what can we learn from consent forms?

PubMed

Henderson, Gail E

2015-01-01

The advent of HIV "cure" research has generated enormous attention, but also concern about its potential to engender false hope, leading to overestimation of benefits and underestimation of risks, and about recruiting relatively healthy participants to studies with uncertain or serious risks. Currently, little is known about potential ethical problems in the ways that informed consent for HIV cure research is described to potential participants. As a first step to address this question, early phase, HIV "cure" research consent forms were analyzed to assess how study aims and potential risks and benefits are presented. Thirteen consent forms from a diverse group of clinical studies were selected to represent the major categories of cure research, including 11 interventional (gene transfer, vaccine intensification, treatment interruption, and latency reversing) and two observational. Consent forms were coded using seven categories, abstracting data on study purpose and design, participant selection criteria, presentation of risks and benefits of participation, and potential return of research results. Findings demonstrate variation and deficiencies that merit attention, but that can largely be addressed by turning to existing guidance about early phase research and specific study designs from other research contexts. The most challenging of these is ensuring that clear, specific, and consistent language is used to describe study aims, risks, benefits, and possible return of results. Informed consent for HIV "cure" research represents an opportunity to apply relevant existing guidance, measure the effectiveness of its application, and develop standardized best-practice policies for consent forms and processes.

Accumulating Evidence and Research Organization (AERO) model: a new tool for representing, analyzing, and planning a translational research program.

PubMed

Hey, Spencer Phillips; Heilig, Charles M; Weijer, Charles

2013-05-30

Maximizing efficiency in drug development is important for drug developers, policymakers, and human subjects. Limited funds and the ethical imperative of risk minimization demand that researchers maximize the knowledge gained per patient-subject enrolled. Yet, despite a common perception that the current system of drug development is beset by inefficiencies, there remain few approaches for systematically representing, analyzing, and communicating the efficiency and coordination of the research enterprise. In this paper, we present the first steps toward developing such an approach: a graph-theoretic tool for representing the Accumulating Evidence and Research Organization (AERO) across a translational trajectory. This initial version of the AERO model focuses on elucidating two dimensions of robustness: (1) the consistency of results among studies with an identical or similar outcome metric; and (2) the concordance of results among studies with qualitatively different outcome metrics. The visual structure of the model is a directed acyclic graph, designed to capture these two dimensions of robustness and their relationship to three basic questions that underlie the planning of a translational research program: What is the accumulating state of total evidence? What has been the translational trajectory? What studies should be done next? We demonstrate the utility of the AERO model with an application to a case study involving the antibacterial agent, moxifloxacin, for the treatment of drug-susceptible tuberculosis. We then consider some possible elaborations for the AERO model and propose a number of ways in which the tool could be used to enhance the planning, reporting, and analysis of clinical trials. The AERO model provides an immediate visual representation of the number of studies done at any stage of research, depicting both the robustness of evidence and the relationship of each study to the larger translational trajectory. In so doing, it makes some of the invisible or inchoate properties of the research system explicit - helping to elucidate judgments about the accumulating state of evidence and supporting decision-making for future research.

Genome Writing: Current Progress and Related Applications.

PubMed

Wang, Yueqiang; Shen, Yue; Gu, Ying; Zhu, Shida; Yin, Ye

2018-02-01

The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects. Copyright © 2018. Production and hosting by Elsevier B.V.

Potential Vaccines and Post-Exposure Treatments for Filovirus Infections

PubMed Central

Friedrich, Brian M.; Trefry, John C.; Biggins, Julia E.; Hensley, Lisa E.; Honko, Anna N.; Smith, Darci R.; Olinger, Gene G.

2012-01-01

Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral infection, there remain no sanctioned therapeutic or vaccine strategies. Current progress in the development of filovirus therapeutics and vaccines is outlined herein with respect to their current level of testing, evaluation, and proximity toward human implementation, specifically with regard to human clinical trials, nonhuman primate studies, small animal studies, and in vitro development. Contemporary methods of supportive care and previous treatment approaches for human patients are also discussed. PMID:23170176

State of the NASA Aeropropulsion Discipline Input from the Glenn Research Center

NASA Technical Reports Server (NTRS)

Reddy, D. R.; Schmidt, George

2017-01-01

PROBLEM: Current power turbines are designed for single operating speed, and performance degrades rapidly as power turbine speed decreases. OBJECTIVES: Demonstrate 50 improvement in efficient operational capability using a Variable Speed Power Turbine concept. (Refer to figure lower left, where the goal is to raise efficiency from the current technology line to the green line which represents the AVSPOT VSPT goal.APPROACH: Conduct RD required to advance the technology readiness level of VSPT technology to TRL 4Partner with DoD and leverage DOD AVSPOT contract to share government cost (5050) of contracted efforts to GE and PW for VSPT TRL 45 demonstration.

Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request.

PubMed

Hogan, William R; Hanna, Josh; Hicks, Amanda; Amirova, Samira; Bramblett, Baxter; Diller, Matthew; Enderez, Rodel; Modzelewski, Timothy; Vasconcelos, Mirela; Delcher, Chris

2017-03-03

The Drug Ontology (DrOn) is an OWL2-based representation of drug products and their ingredients, mechanisms of action, strengths, and dose forms. We originally created DrOn for use cases in comparative effectiveness research, primarily to identify historically complete sets of United States National Drug Codes (NDCs) that represent packaged drug products, by the ingredient(s), mechanism(s) of action, and so on contained in those products. Although we had designed DrOn from the outset to carefully distinguish those entities that have a therapeutic indication from those entities that have a molecular mechanism of action, we had not previously represented in DrOn any particular therapeutic indication. In this work, we add therapeutic indications for three research use cases: resistant hypertension, malaria, and opioid abuse research. We also added mechanisms of action for opioid analgesics and added 108 classes representing drug products in response to a large term request from the Program for Resistance, Immunology, Surveillance and Modeling of Malaria in Uganda (PRISM) project. The net result is a new version of DrOn, current to May 2016, that represents three major therapeutic classes of drugs and six new mechanisms of action. A therapeutic indication of a drug product is represented as a therapeutic function in DrOn. Adverse effects of drug products, as well as other therapeutic uses for which the drug product was not designed are dispositions. Our work provides a framework for representing additional therapeutic indications, adverse effects, and uses of drug products beyond their design. Our work also validated our past modeling decisions for specific types of mechanisms of action, namely effects mediated via receptor and/or enzyme binding. DrOn is available at: http://purl.obolibrary.org/obo/dron.owl . A smaller version without NDCs is available at: http://purl.obolibrary.org/obo/dron/dron-lite.owl.

Controlling Fringe Sensitivity of Electro-Optic Holography Systems Using Laser Diode Current Modulation

NASA Technical Reports Server (NTRS)

Bybee, Shannon J.

2001-01-01

Electro-Optic Holography (EOH) is a non-intrusive, laser-based, displacement measurement technique capable of static and dynamic displacement measurements. EOH is an optical interference technique in which fringe patterns that represent displacement contour maps are generated. At excessively large displacements the fringe density may be so great that individual fringes are not resolvable using typical EOH techniques. This thesis focuses on the development and implementation of a method for controlling the sensitivity of the EOH system. This method is known as Frequency Translated Electro-Optic Holography (FTEOH). It was determined that by modulating the current source of the laser diode at integer multiples of the object vibration, the fringe pattern is governed by higher order Bessel function of the first kind and the number of fringes that represent a given displacement can be controlled. The reduction of fringes is theoretically unlimited but physically limited by the frequency bandwidth of the signal generator, providing modulation to the laser diode. Although this research technique has been verified theoretically and experimentally in this thesis, due to the current laser diode capabilities it is a tedious and time consuming process to acquire data using the FTEOH technique.

Results of research on development of an intellectual information system of bankruptcy risk assessment of the enterprise

NASA Astrophysics Data System (ADS)

Telipenko, E.; Chernysheva, T.; Zakharova, A.; Dumchev, A.

2015-10-01

The article represents research results about the knowledge base development for the intellectual information system for the bankruptcy risk assessment of the enterprise. It is described the process analysis of the knowledge base development; the main process stages, some problems and their solutions are given. The article introduces the connectionist model for the bankruptcy risk assessment based on the analysis of industrial enterprise financial accounting. The basis for this connectionist model is a three-layer perceptron with the back propagation of error algorithm. The knowledge base for the intellectual information system consists of processed information and the processing operation method represented as the connectionist model. The article represents the structure of the intellectual information system, the knowledge base, and the information processing algorithm for neural network training. The paper shows mean values of 10 indexes for industrial enterprises; with the help of them it is possible to carry out a financial analysis of industrial enterprises and identify correctly the current situation for well-timed managerial decisions. Results are given about neural network testing on the data of both bankrupt and financially strong enterprises, which were not included into training and test sets.

Temperament and personality in bipolar II disorder.

PubMed

Fletcher, Kathryn; Parker, Gordon; Barrett, Melissa; Synnott, Howe; McCraw, Stacey

2012-02-01

There is limited research examining temperament and personality in bipolar II disorder. We sought to determine any over-represented temperament and personality features in bipolar II disorder compared to other affective groups. Scores on a self-report measure of temperament and personality were examined in a sample of 443 participants diagnosed with unipolar, bipolar I and bipolar II disorder. After controlling for age, gender, age of depression onset and current depression severity, those with bipolar II disorder were characterized by higher irritability, anxious worrying, self-criticism and interpersonal sensitivity scores, and with lower social avoidance scores compared to unipolar participants. No differences were found between bipolar sub-types on any temperament and personality sub-scales. Limitations included the lack of a control group, a relatively small sample of bipolar I participants, and with the cross-sectional design disallowing conclusions regarding premorbid personality traits as opposed to illness 'scarring' effects. Further research should seek to clarify whether certain temperament and personality styles are over-represented in bipolar II disorder. Any over-represented characteristics may assist with diagnostic differentiation from phenomenologically similar conditions and lead to more appropriate clinical management. Copyright © 2011 Elsevier B.V. All rights reserved.

Core Research Center

USGS Publications Warehouse

Hicks, Joshua; Adrian, Betty

2009-01-01

The Core Research Center (CRC) of the U.S. Geological Survey (USGS), located at the Denver Federal Center in Lakewood, Colo., currently houses rock core from more than 8,500 boreholes representing about 1.7 million feet of rock core from 35 States and cuttings from 54,000 boreholes representing 238 million feet of drilling in 28 States. Although most of the boreholes are located in the Rocky Mountain region, the geologic and geographic diversity of samples have helped the CRC become one of the largest and most heavily used public core repositories in the United States. Many of the boreholes represented in the collection were drilled for energy and mineral exploration, and many of the cores and cuttings were donated to the CRC by private companies in these industries. Some cores and cuttings were collected by the USGS along with other government agencies. Approximately one-half of the cores are slabbed and photographed. More than 18,000 thin sections and a large volume of analytical data from the cores and cuttings are also accessible. A growing collection of digital images of the cores are also becoming available on the CRC Web site Internet http://geology.cr.usgs.gov/crc/.

Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hickman, R.; Anspaugh, L.

1985-04-01

FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scalemore » activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs.« less

Assessing the impact of fine particulate matter (PM2.5) on ...

EPA Pesticide Factsheets

An enhanced research paradigm is presented to address the spatial and temporal gaps in fine particulate matter (PM2.5) measurements and generate realistic and representative concentration fields for use in epidemiological studies of human exposure to ambient air particulate concentrations. The general approach for research designed to analyze health impacts of exposure to PM2.5 is to use concentration data from the nearest ground-based air quality monitor(s), which typically have missing data on the temporal and spatial scales due to filter sampling schedules and monitor placement, respectively. To circumvent these data gaps, this research project uses a Hierarchical Bayesian Model (HBM) to generate estimates of PM2.5 in areas with and without air quality monitors by combining PM2.5 concentrations measured by monitors, PM2.5 concentration estimates derived from satellite aerosol optical depth (AOD) data, and Community-Multiscale Air Quality (CMAQ) model predictions of PM2.5 concentrations. This methodology represents a substantial step forward in the approach for developing representative PM2.5 concentration datasets to correlate with inpatient hospitalizations and emergency room visits data for asthma and inpatient hospitalizations for myocardial infarction (MI) and heart failure (HF) using case-crossover analysis. There were two key objective of this current study. First was to show that the inputs to the HBM could be expanded to include AOD data in addition t

Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies

PubMed Central

Rabin, Laura A.; Smart, Colette M.; Crane, Paul K.; Amariglio, Rebecca E.; Berman, Lorin M.; Boada, Mercè; Buckley, Rachel F.; Chételat, Gaël; Dubois, Bruno; Ellis, Kathryn A.; Gifford, Katherine A.; Jefferson, Angela L.; Jessen, Frank; Katz, Mindy J.; Lipton, Richard B.; Luck, Tobias; Maruff, Paul; Mielke, Michelle M.; Molinuevo, José Luis; Naeem, Farnia; Perrotin, Audrey; Petersen, Ronald C.; Rami, Lorena; Reisberg, Barry; Rentz, Dorene M.; Riedel-Heller, Steffi G.; Risacher, Shannon L.; Rodriguez, Octavio; Sachdev, Perminder S.; Saykin, Andrew J.; Slavin, Melissa J.; Snitz, Beth E.; Sperling, Reisa A.; Tandetnik, Caroline; van der Flier, Wiesje M.; Wagner, Michael; Wolfsgruber, Steffen; Sikkes, Sietske A.M.

2015-01-01

Research increasingly suggests that subjective cognitive decline (SCD) in older adults, in the absence of objective cognitive dysfunction or depression, may be a harbinger of non-normative cognitive decline and eventual progression to dementia. Little is known, however, about the key features of self-report measures currently used to assess SCD. The Subjective Cognitive Decline Initiative (SCD-I) Working Group is an international consortium established to develop a conceptual framework and research criteria for SCD (Jessen et al., 2014, Alzheimers Dement 10, 844–852). In the current study we systematically compared cognitive self-report items used by 19 SCD-I Working Group studies, representing 8 countries and 5 languages. We identified 34 self-report measures comprising 640 cognitive self-report items. There was little overlap among measures—approximately 75% of measures were used by only one study. Wide variation existed in response options and item content. Items pertaining to the memory domain predominated, accounting for about 60% of items surveyed, followed by executive function and attention, with 16% and 11% of the items, respectively. Items relating to memory for the names of people and the placement of common objects were represented on the greatest percentage of measures (56% each). Working group members reported that instrument selection decisions were often based on practical considerations beyond the study of SCD specifically, such as availability and brevity of measures. Results document the heterogeneity of approaches across studies to the emerging construct of SCD. We offer preliminary recommendations for instrument selection and future research directions including identifying items and measure formats associated with important clinical outcomes. PMID:26402085

Clinical Adoption of Prognostic Biomarkers The Case for Heart Failure

PubMed Central

Kalogeropoulos, Andreas P.; Georgiopoulou, Vasiliki V.; Butler, Javed

2013-01-01

The recent explosion of scientific knowledge and technological progress has led to the discovery of a large array of circulating molecules commonly referred to as biomarkers. Biomarkers in heart failure research have been used to provide pathophysiological insights, aid in establishing the diagnosis, refine prognosis, guide management, and target treatment. However, beyond diagnostic applications of natriuretic peptides, there are currently few widely recognized applications for biomarkers in heart failure. This represents a remarkable discordance considering the number of molecules that have been shown to correlate with outcomes, refine risk prediction, or track disease severity in heart failure in the past decade. In this article, we use a broad framework proposed for cardiovascular risk markers to summarize the current state of biomarker development for heart failure patients. We utilize this framework to identify the challenges of biomarker adoption for risk prediction, disease management, and treatment selection for heart failure and suggest considerations for future research. PMID:22824105

The integration of epigenetics and genetics in nutrition research for CVD risk factors.

PubMed

Ma, Yiyi; Ordovas, Jose M

2017-08-01

There is increasing evidence documenting gene-by-environment (G × E) interactions for CVD related traits. However, the underlying mechanisms are still unclear. DNA methylation may represent one of such potential mechanisms. The objective of this review paper is to summarise the current evidence supporting the interplay among DNA methylation, genetic variants, and environmental factors, specifically (1) the association between SNP and DNA methylation; (2) the role that DNA methylation plays in G × E interactions. The current evidence supports the notion that genotype-dependent methylation may account, in part, for the mechanisms underlying observed G × E interactions in loci such as APOE, IL6 and ATP-binding cassette A1. However, these findings should be validated using intervention studies with high level of scientific evidence. The ultimate goal is to apply the knowledge and the technology generated by this research towards genetically based strategies for the development of personalised nutrition and medicine.

Glycobiology of Reproductive Processes in Marine Animals: The State of the Art

PubMed Central

Gallo, Alessandra; Costantini, Maria

2012-01-01

Glycobiology is the study of complex carbohydrates in biological systems and represents a developing field of science that has made huge advances in the last half century. In fact, it combines all branches of biomedical research, revealing the vast and diverse forms of carbohydrate structures that exist in nature. Advances in structure determination have enabled scientists to study the function of complex carbohydrates in more depth and to determine the role that they play in a wide range of biological processes. Glycobiology research in marine systems has primarily focused on reproduction, in particular for what concern the chemical communication between the gametes. The current status of marine glycobiology is primarily descriptive, devoted to characterizing marine glycoconjugates with potential biomedical and biotechnological applications. In this review, we describe the current status of the glycobiology in the reproductive processes from gametogenesis to fertilization and embryo development of marine animals. PMID:23247316

Basic principles of coaxial launch technology

NASA Technical Reports Server (NTRS)

Kolm, H.; Mongeau, P.

1984-01-01

Already in the 1930s, a discrete-coil mechanically synchronized launcher was built. At the present time, research is almost entirely directed towards railguns. However, although coaxial accelerators are more complex than railguns, they have certain unique advantages. Some of these advantages are related to the absence of physical contact requirements with the projectile, the possibility of a scale-up to very large projectile size, and the availability of up to 100 times more thrust for a given current. The price of the advantages is the need for a drive current in the form of pulses synchronized precisely with transit of each projectile coil through each drive coil. At high velocities, high voltages are required, and high voltage switching represents the technology limit on launch velocity. Attention is given to inductance gradients, the double hump, methods of excitation, methods of synchronization, projectile configuration, energy supply, fundamental limits, trends, and research needs.

Ebola: a holistic approach is required to achieve effective management and control.

PubMed

Roca, Anna; Afolabi, Muhammed O; Saidu, Yauba; Kampmann, Beate

2015-04-01

The current Ebola outbreak in West Africa has already caused substantial mortality and dire human and economic consequences. It continues to represent an alarming public health threat in the region and beyond and jeopardizes the provision of health care and other services in the affected countries. The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding. Our knowledge relating to the virus, disease pathogenesis, risk factors, dynamics of transmission, and epidemic control is increasing, and sociocultural factors have emerged as critical determinants for the success and failure of control efforts. However, there is a long way to go. In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

[Current legal framework conditions for running and utilization of biobanks. Part 2: data protection and informed consent].

PubMed

Haier, J

2013-10-01

Informed consent of donors of biomaterials represents an essential pillar of legal conformity of business organizations even for biobanks. For the assessment of self-determination of donors and freedom of research for users of biobanks there is a general consensus on the necessity for a social and individual agreement for the participation of donors in research projects. However, demands are often made for which the legal implementation is at least contentious and can be considered as excessive and biased. In part 2 of this review series the current legal foundation of data protection and informed consent is summarized on the basis of normative and ethical principles. With respect to appropriation of data and biosamples it can be deduced that by conformation to corresponding framework conditions the informed consent of donors in particular can be constructed independent of the project.

Social problem solving strategies and posttraumatic stress disorder in the aftermath of intimate partner violence.

PubMed

Reich, Catherine M; Blackwell, Náthali; Simmons, Catherine A; Beck, J Gayle

2015-05-01

Social factors are often associated with the development or maintenance of posttraumatic stress disorder (PTSD) in the aftermath of interpersonal traumas. However, social problem solving strategies have received little attention. The current study explored the role of social problem solving styles (i.e., rational approaches, impulsive/careless strategies, or avoidance strategies) as intermediary variables between abuse exposure and PTSD severity among intimate partner violence survivors. Avoidance problem solving served as an intermediating variable for the relationship between three types of abuse and PTSD severity. Rational and impulsive/careless strategies were not associated with abuse exposure. These findings extend the current understanding of social problem solving among interpersonal trauma survivors and are consistent with more general avoidance coping research. Future research might examine whether avoidance problem solving tends to evolve in the aftermath of trauma or whether it represents a longstanding risk factor for PTSD development. Published by Elsevier Ltd.

Emerging drugs for the treatment of wound healing.

PubMed

Zielins, Elizabeth R; Brett, Elizabeth A; Luan, Anna; Hu, Michael S; Walmsley, Graham G; Paik, Kevin; Senarath-Yapa, Kshemendra; Atashroo, David A; Wearda, Taylor; Lorenz, H Peter; Wan, Derrick C; Longaker, Michael T

2015-06-01

Wound healing can be characterized as underhealing, as in the setting of chronic wounds, or overhealing, occurring with hypertrophic scar formation after burn injury. Topical therapies targeting specific biochemical and molecular pathways represent a promising avenue for improving and, in some cases normalizing, the healing process. A brief overview of both normal and pathological wound healing has been provided, along with a review of the current clinical guidelines and treatment modalities for chronic wounds, burn wounds and scar formation. Next, the major avenues for wound healing drugs, along with drugs currently in development, are discussed. Finally, potential challenges to further drug development, and future research directions are discussed. The large body of research concerning wound healing pathophysiology has provided multiple targets for topical therapies. Growth factor therapies with the ability to be targeted for localized release in the wound microenvironment are most promising, particularly when they modulate processes in the proliferative phase of wound healing.

Current challenges in autonomous vehicle development

NASA Astrophysics Data System (ADS)

Connelly, J.; Hong, W. S.; Mahoney, R. B., Jr.; Sparrow, D. A.

2006-05-01

The field of autonomous vehicles is a rapidly growing one, with significant interest from both government and industry sectors. Autonomous vehicles represent the intersection of artificial intelligence (AI) and robotics, combining decision-making with real-time control. Autonomous vehicles are desired for use in search and rescue, urban reconnaissance, mine detonation, supply convoys, and more. The general adage is to use robots for anything dull, dirty, dangerous or dumb. While a great deal of research has been done on autonomous systems, there are only a handful of fielded examples incorporating machine autonomy beyond the level of teleoperation, especially in outdoor/complex environments. In an attempt to assess and understand the current state of the art in autonomous vehicle development, a few areas where unsolved problems remain became clear. This paper outlines those areas and provides suggestions for the focus of science and technology research. The first step in evaluating the current state of autonomous vehicle development was to develop a definition of autonomy. A number of autonomy level classification systems were reviewed. The resulting working definitions and classification schemes used by the authors are summarized in the opening sections of the paper. The remainder of the report discusses current approaches and challenges in decision-making and real-time control for autonomous vehicles. Suggested research focus areas for near-, mid-, and long-term development are also presented.

Opportunities for Success: Cost Effective Programs for Children Update, 1988. A Report of the Select Committee on Children, Youth and Families, U.S. House of Representatives, One Hundredth Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

Based on findings of the most current and highly regarded evaluations and research reviews available, this committee print provides an update of a prior committee report (August, 1985) on eight cost-effective federal programs for children. Described in terms of program participation, characteristics, benefits for children, cost effectiveness, and…

Re-Presenting the Social Construction of Science in Light of the Propositions of Bruno Latour: For a Renewal of the School Conception of Science in Secondary Schools

ERIC Educational Resources Information Center

Richard, Vincent; Bader, Barbara

2010-01-01

Current opinion holds that school science has not been producing the expected outcomes. Highlighted by a considerable body of research, one of the concerns is that young people still mobilize a naive conception of science. Consequently, we must pursue the reflection process concerning ways of renewing the school conception of science so as to…

United States and Western European Terrorist Groups - Current Status and Future Perspective.

DTIC Science & Technology

1982-06-07

State, p. 173, 174 A respected commentator on terrorism, Walter Laqueur, Chairman of the International Research Council of the Center for Strategic ...American Nazi Party), the Black Panther Party, ( BPP ) and the American Indian Movement (AIM) were primarily involved in terrorist efforts in the late 60s...claiming to represent the JDL telephoned news organizations and said that the militant group was responsible for the fire. Subsequently leaders of the JDL

Megawatt-Scale Power Hardware-in-the-Loop Simulation Testing of a Power Conversion Module for Naval Applications

DTIC Science & Technology

2015-06-21

problem was detected . Protection elements were implemented to trigger on over- voltage , over-current, over/under-frequency, and zero-sequence voltage ...power hardware in the loop simulation of distribution networks with photovoltaic generation,” International Journal of Renewable Energy Research...source modules were intended to support both emulation of a representative gas turbine generator set, as well as a flexible, controllable voltage source

Molecular Signature Reveals Which Liver Cancer Patients May Benefit from a New Drug | Center for Cancer Research

Cancer.gov

Only one drug currently on the market has the potential to extend survival for patients with advanced-stage liver cancer and only 30 percent of patients are eligible to receive it. As the fastest-growing type of cancer by incidence in the United States, liver cancer represents a major public health problem and there is an urgent need to develop new treatment strategies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfiffner, Susan M.

Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), Florida State University (FSU), and the University of Tennessee. ORNL will serve as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project was initiated in November, 2004, in the Integrative Studies Element of the NABIR program. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

Neurophysiologic Methods to Measure Stress During Survival, Evasion, Resistance, and Escape Training

DTIC Science & Technology

2007-05-01

amygdala function as well as perceived stress, trait anxiety , and trait anger. Overview of current research strategy: HRV analysis represents another...expected to relate to perceived stress, trait anxiety , and trait anger. In prospective analyses, HRV is expected to pre- dict cortisol reactivity...studying brain activity linked with fear, anxiety , and other emotional states in humans, is described in this section. The ASER is elicited by an abrupt

Mid-Infrared Optoelectronics: Materials and Devices. MIOMD-XII

DTIC Science & Technology

2014-10-01

current. An enhancement of the QEPAS signal can be achieved when two metallic tubes acting as a micro‐ resonator (mR) are added to the QTF sensor ...spectrophone configuration using a 5.8 mm long micro‐ resonator with an inner diameter of 0.80 mm [3]. In order to test and validate the developed QEPAS sensor ...materials, photodetectors, sensors and applications have been discussed in other sessions. The papers were submitted by researchers representing 107

Physical Modeling Techniques for Missile and Other Protective Structures

DTIC Science & Technology

1983-06-29

uniaxial load only. In general , axial thrust was applied with an: initial eccentricity of zero on the specimen end. Sixteen different combinations of Pa...conditioning electronics and cabling schemes is included. The techniques described generally represent current approaches at the Civil Engineering Research...at T- zero and stopping when a pulse is generated by the pi-ezoelectric disc on arrival of! the detonation wave front. All elapsed time data is stored

Teenage Drug Use: Uncertain Linkages with Either Pregnancy or School Dropout. Report to the Chairman, Select Committee on Narcotics Abuse and Control, House of Representatives.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC.

The study reported in this document is a follow-up to earlier reviews of drugs and other youth problems. It addressed the current status of and the recent trends in teenage drug use, pregnancy, and dropping out of school, and the post-1987 research about the relationship between teenage drug use and either pregnancy or dropping out. Statistics…

Competitive styles in men and women.

PubMed

Reed, S; Reed, R C; Lantz, J

1997-01-01

Competition is a function intrinsic to current clinical practice. Of the two competitive styles, goal competitiveness is found by both men and women to be more worthy of respect. Interpersonal competitiveness is manifested more by highly competitive women than by highly competitive men, especially in relationships with female co-workers, representing a significant problem for organizations and employees. The styles and their effects are described, their possible sources discussed, additional research outlined, and recommendations proposed.

Collaborating with consumer and community representatives in health and medical research in Australia: results from an evaluation.

PubMed

Payne, Janet M; D'Antoine, Heather A; France, Kathryn E; McKenzie, Anne E; Henley, Nadine; Bartu, Anne E; Elliott, Elizabeth J; Bower, Carol

2011-05-14

To collaborate with consumer and community representatives in the Alcohol and Pregnancy Project from 2006-2008 http://www.ichr.uwa.edu.au/alcoholandpregnancy and evaluate researchers' and consumer and community representatives' perceptions of the process, context and impact of consumer and community participation in the project. We formed two reference groups and sought consumer and community representatives' perspectives on all aspects of the project over a three year period. We developed an evaluation framework and asked consumer and community representatives and researchers to complete a self-administered questionnaire at the end of the project. Fifteen researchers (93.8%) and seven (53.8%) consumer and community representatives completed a questionnaire. Most consumer and community representatives agreed that the process and context measures of their participation had been achieved. Both researchers and consumer and community representatives identified areas for improvement and offered suggestions how these could be improved for future research. Researchers thought consumer and community participation contributed to project outputs and outcomes by enhancing scientific and ethical standards, providing legitimacy and authority, and increasing the project's credibility and participation. They saw it was fundamental to the research process and acknowledged consumer and community representatives for their excellent contribution. Consumer and community representatives were able to directly influence decisions about the research. They thought that consumer and community participation had significant influence on the success of project outputs and outcomes. Consumer and community participation is an essential component of good research practice and contributed to the Alcohol and Pregnancy Project by enhancing research processes, outputs and outcomes, and this participation was valued by community and consumer representatives and researchers. The National Health and Medical Research Council in Australia expects researchers to work in partnership and involve consumer and community representatives in health and medical research, and to evaluate community and consumer participation. It is important to demonstrate whether consumer and community participation makes a difference to health and medical research.

Collaborating with consumer and community representatives in health and medical research in Australia: results from an evaluation

PubMed Central

2011-01-01

Objective To collaborate with consumer and community representatives in the Alcohol and Pregnancy Project from 2006-2008 http://www.ichr.uwa.edu.au/alcoholandpregnancy and evaluate researchers' and consumer and community representatives' perceptions of the process, context and impact of consumer and community participation in the project. Methods We formed two reference groups and sought consumer and community representatives' perspectives on all aspects of the project over a three year period. We developed an evaluation framework and asked consumer and community representatives and researchers to complete a self-administered questionnaire at the end of the project. Results Fifteen researchers (93.8%) and seven (53.8%) consumer and community representatives completed a questionnaire. Most consumer and community representatives agreed that the process and context measures of their participation had been achieved. Both researchers and consumer and community representatives identified areas for improvement and offered suggestions how these could be improved for future research. Researchers thought consumer and community participation contributed to project outputs and outcomes by enhancing scientific and ethical standards, providing legitimacy and authority, and increasing the project's credibility and participation. They saw it was fundamental to the research process and acknowledged consumer and community representatives for their excellent contribution. Consumer and community representatives were able to directly influence decisions about the research. They thought that consumer and community participation had significant influence on the success of project outputs and outcomes. Conclusions Consumer and community participation is an essential component of good research practice and contributed to the Alcohol and Pregnancy Project by enhancing research processes, outputs and outcomes, and this participation was valued by community and consumer representatives and researchers. The National Health and Medical Research Council in Australia expects researchers to work in partnership and involve consumer and community representatives in health and medical research, and to evaluate community and consumer participation. It is important to demonstrate whether consumer and community participation makes a difference to health and medical research. PMID:21569591

Multidimensional stock network analysis: An Escoufier's RV coefficient approach

NASA Astrophysics Data System (ADS)

Lee, Gan Siew; Djauhari, Maman A.

2013-09-01

The current practice of stocks network analysis is based on the assumption that the time series of closed stock price could represent the behaviour of the each stock. This assumption leads to consider minimal spanning tree (MST) and sub-dominant ultrametric (SDU) as an indispensible tool to filter the economic information contained in the network. Recently, there is an attempt where researchers represent stock not only as a univariate time series of closed price but as a bivariate time series of closed price and volume. In this case, they developed the so-called multidimensional MST to filter the important economic information. However, in this paper, we show that their approach is only applicable for that bivariate time series only. This leads us to introduce a new methodology to construct MST where each stock is represented by a multivariate time series. An example of Malaysian stock exchange will be presented and discussed to illustrate the advantages of the method.

The spatial representation of power in children.

PubMed

Lu, Lifeng; Schubert, Thomas W; Zhu, Lei

2017-11-01

Previous evidence demonstrates that power is mentally represented as vertical space by adults. However, little is known about how power is mentally represented in children. The current research examines such representations. The influence of vertical information (motor cues) was tested in both an explicit power evaluation task (judge whether labels refer to powerless or powerful groups) and an incidental task (judge whether labels refer to people or animals). The results showed that when power was explicitly evaluated, vertical motor responses interfered with responding in children and adults, i.e., they responded to words representing powerful groups faster with the up than the down cursor key (and vice versa for powerless groups). However, this interference effect disappeared in the incidental task in children. The findings suggest that children have developed a spatial representation of power before they have been taught power-space associations formally, but that they do not judge power spontaneously.

Tales from the frontline: the experiences of early childhood practitioners working with an 'embedded' research team.

PubMed

Wong, Sandie

2009-05-01

In late 2006, SDN Children's Services, an Australian not-for-profit provider of services for children, families and communities, engaged a research team that was 'embedded' within the organisation for 1 year. This action represented a significant investment of resources, such as staff time and organisational funds, and demonstrates SDN's strong commitment to research and evaluation as a means of supporting organisational learning and development. This paper highlights the innovative nature of the approach by positioning the role of the embedded researcher within the current theoretical and socio-political context. It also provides evidence of the success of the approach by reporting on the findings of a study that investigated staff's experiences of being involved in this type of collaborative investigation of their work. I argue that the employment of an embedded researcher can have positive benefits both for the organisation and the practitioners--but who the researchers are really matters.

Under representation of people with epilepsy and intellectual disability in research.

PubMed

Shankar, Rohit; Rowe, Charles; Van Hoorn, Alje; Henley, William; Laugharne, Richard; Cox, David; Pande, Raj; Roy, Ashok; Sander, Josemir W

2018-01-01

One quarter of people with epilepsy have an intellectual disability (ID) and one fifth of people with an ID have epilepsy. Both conditions are associated with higher levels of morbidity, stigma and premature mortality. There have been calls for action to promote more research in this group. We examined if this group are represented adequately in current research. The proportion of research output in epilepsy conferences and publications relevant to ID and the proportion in ID conferences and publications on epilepsy for 2015-2016 were identified. As the percentage of children in the population with epilepsy is 17%, research output of this group was compared with the ID group. Recognised material was classified based on whether it applied to general epilepsy/ID research, children with epilepsy or people with epilepsy and ID. Data was analysed to determine the proportion of presented research specifically identifying people with epilepsy and ID. Fewer than 2% of presentations at epilepsy conferences specifically related to the ID and epilepsy group compared to 15% relating to children with epilepsy. Similarly only 1.4% of the research presented at major ID conferences related to those with people with epilepsy and ID. About 5% of published research in the field of epilepsy related to those with ID as compared with 24% for children with epilepsy. Twelve percent of published research in ID specifically identified epilepsy. Publications and conference presentations, on the population with epilepsy and comorbid ID is under-represented. Increased research in this area might assist in improving the quality of care for this relatively neglected group.

Passive Consent for Clinical Research in the Age of HIPAA

PubMed Central

Littenberg, Benjamin; MacLean, Charles D

2006-01-01

BACKGROUND Federal laws and regulations, including the Health Insurance Portability and Accountability Act (HIPAA) of 1996, intended primarily to protect individuals, have been described as significant barriers to the use of clinical registries and other population-based tools for health care research. Although these regulations allow for the waiver or alteration of usual consent procedures when the research meets certain specific criteria, waivers and alterations are rarely used in health care research. METHODS The Vermont Diabetes Information System is a multistate randomized trial of a quality improvement intervention that uses a novel alteration of informed consent to help ensure that the study sample is representative of the target population. Patients are notified by mail that they are eligible for the study and that they may opt out of the study, if they desire, by calling a toll-free number. RESULTS Seven thousand five hundred and fifty-eight patients were invited to participate. Two hundred and ten (2.8%) opted out. Three patients (0.04%) filed complaints, all of which were addressed satisfactorily. CONCLUSIONS Health Insurance Portability and Accountability Act and other federal regulations raise challenges to the use of clinical registries in research, but modifications to the consent process, including passive consent methods, are useful tools to overcome these challenges. It is possible to recruit a broad and representative population under current law while maintaining appropriate protections for research subjects. PMID:16637821

Partners in projects: preparing for public involvement in health and social care research.

PubMed

Parkes, Jacqueline H; Pyer, Michelle; Wray, Paula; Taylor, Jane

2014-09-01

In recent years, several UK and, international funders of health and social care related research have adopted the policy of requiring explicit evidence of the 'public' voice in all aspects of project design. For many academic researchers engaged within research, evaluations or audit projects, this formal requirement to actively engage members of the public will present them with both benefits and challenges to securing knowledgeable, skilled, and confident lay representation onto project teams. This could potentially lead to the exploitation of those individuals who are available, appropriately informed, and adequately prepared for such activities. Currently, much of the preparation of patients or members of the public for research involvement tends to be aligned to specific projects; however, with the call for greater active and meaningful involvement of lay representatives in future national and international funding applications, there is clearly a growing need to 'train' sufficient numbers of confident and competent representatives to meet this growing demand. This paper describes the development of a specifically designed research awareness training programme and underpinning theoretical model, which has been specifically designed to support active and meaningful lay involvement in research, evaluations and audit projects. Developed over a four year period, the course is a culmination of learning extracted from a series of four completed research projects, which have incorporated an element of public and patient involvement (PPI) training in their overall design. Crown Copyright © 2014. Published by Elsevier Ireland Ltd. All rights reserved.

The BTBR mouse model of idiopathic autism – current view on mechanisms

PubMed Central

Meyza, K. Z.; Blanchard, D. C.

2017-01-01

Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder, with current estimates of more than 1% of affected children across nations. The patients form a highly heterogeneous group with only the behavioral phenotype in common. The genetic heterogeneity is reflected in a plethora of animal models representing multiple mutations found in families of affected children. Despite many years of scientific effort, for the majority of cases the genetic cause remains elusive. It is therefore crucial to include well-validated models of idiopathic autism in studies searching for potential therapeutic agents. One of these models is the BTBR T+Itpr3tf/J mouse. The current review summarizes data gathered in recent research on potential molecular mechanisms responsible for the autism-like behavioral phenotype of this strain. PMID:28167097

Lennie: a smartphone application with novel implications for the management of animal colonies.

PubMed

Allwood, M A; Griffith, D; Allen, C; Reed, J; Mahmoud, Q H; Brunt, K R; Simpson, J A

2015-07-01

Researchers rely on animals for their clinical applicability and ease of monitoring. However, careful management is required to ensure the animal and financial costs are minimized. The incorporation of 'smartphone' technology in research has increased exponentially, with a focus on the development of innovative research-based applications. We have developed a smartphone application designed to address the needs of modern researchers in the management of their colonies. 'Lennie' introduces a new method for the management of small to medium-sized animal colonies. Lennie allows users wireless access to their colonies with the ability to create and edit from virtually anywhere. Lennie also offers the ability to manage colonies based on experiments by assigning animals based on priority. Experimental time-points are also recorded with integrated scheduling options using the calendar function. Lennie represents an alternative to current large-scale software options, as the application design is simple, and requires no training or manuals. As the technological landscape is constantly evolving, we must continue to find ways to improve upon current practices to ensure that research is completed with efficiency and efficacy. With this new method of animal management, researchers are able to spend less time record keeping and can focus their efforts on continued innovation. © The Author(s) 2015.

The U.S.-Russian radiation health effects research program in the Southern Urals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seligman, P.J.

2000-07-01

The Joint Coordinating Committee for Radiation Effects Research (JCCRER) was established through a bilateral US-Russian agreement to support research and exchange information on radiation health effects. The U.S. member agencies include the Department of Energy (DOE), Nuclear Regulatory Commission (NRC), Department of Health and Human Services (DHHS), Department of Defense (DoD), National Aeronautics and Space Administration (NASA), and Environmental Protection Agency (EPA). The Russians are represented by the Ministries of Emergencies (EMERCOM), the Atomic Energy (MINATOM) and Health (MINZDRAV), and the Russian Academy of Sciences (IBRAE). The focus of this research is on the workers from the Mayak Production Associationmore » (MAYAK) in the Southern Urals and on the neighboring populations along the Techa River exposed to contamination from the plant. The goal of the program is to better define the relationship between the health effects and the chronic low dose and dose-rate exposure, these data being essential to validate current radiation protection standards and practices. The current primary areas of JCCRER research include dose reconstruction, epidemiologic health studies, molecular epidemiology/biodosimetry, and the creation of tissue banks. The organization of the ongoing research conducted under the aegis of the JCCRER and the rationale for this work are described.« less

Collaborative research in medical education: a discussion of theory and practice.

PubMed

O'Sullivan, Patricia S; Stoddard, Hugh A; Kalishman, Summers

2010-12-01

Medical education researchers are inherently collaborators. This paper presents a discussion of theoretical frameworks, issues and challenges around collaborative research to prepare medical education researchers to enter into successful collaborations. It gives emphasis to the conceptual issues associated with collaborative research and applies these to medical education research. Although not a systematic literature review, the paper provides a rich discussion of issues which medical education researchers might consider when undertaking collaborative studies. Building on the work of others, we have classified collaborative research in three dimensions according to: the number of administrative units represented; the number of academic fields present, and the manner in which knowledge is created. Although some literature on collaboration focuses on the more traditional positivist perspective and emphasises outcomes, other literature comes from the constructivist framework, in which research is not driven by hypotheses and the approaches emphasised, but by the interaction between investigator and subject. Collaborations are more effective when participants overtly clarify their motivations, values, definitions of appropriate data and accepted methodologies. These should be agreed upon prior to commencing a study. The way we currently educate researchers should be restructured if we want them to be able to undertake interdisciplinary research. Despite calls for researchers to be educated differently, most training programmes for developing researchers have demonstrated a limited, if not contrary, response to these calls. Collaborative research in medical education should be driven by the problem being investigated, by the new knowledge gained and by the interpersonal interactions that may be achieved. Success rests on recognising that many of the research problems we, as medical educators, address are fundamentally interdisciplinary in nature. This represents a transition to bridge the dichotomy often presented in medical education between theory building and addressing practical needs. © Blackwell Publishing Ltd 2010.

An observational examination of the literature in diagnostic anatomic pathology.

PubMed

Foucar, Elliott; Wick, Mark R

2005-05-01

Original research published in the medical literature confronts the reader with three very basic and closely linked questions--are the authors' conclusions true in the contextual setting in which the work was performed (internally valid); if so, are the conclusions also applicable in other practice settings (externally valid); and, if the conclusions of the study are bona fide, do they represent an important contribution to medical practice or are they true-but-insignificant? Most publications attempt to convince readers that the researchers' conclusions are both internally valid and important, and occasionally papers also directly address external validity. Developing standardized methods to facilitate the prospective determination of research importance would be useful to both journals and their readers, but has proven difficult. In contrast, the evidence-based medicine (EBM) movement has had more success with understanding and codifying factors thought to promote research validity. Of the many variables that can influence research validity, research design is the one that has received the most attention. The present paper reviews the contributions of EBM to understanding research validity, looking for areas where EBM's body of knowledge is applicable to the anatomic pathology (AP) literature. As part of this project, the authors performed a pilot observational analysis of a representative sample of the current pertinent literature on diagnostic tissue pathology. The results of that review showed that most of the latter publications employ one of the four categories of "observational" research design that have been delineated by the EBM movement, and that the most common of these observational designs is a "cross-sectional" comparison. Pathologists do not presently use the "experimental" research designs so admired by advocates of EBM. Slightly > 50% of AP observational studies employed statistical evaluations to support their final conclusions. Comparison of the current AP literature with a selected group of papers published in 1977 shows a discernible change over that period that has affected not just technological procedures, but also research design and use of statistics. Although we feel that advocates of EBM deserve credit for bringing attention to the close link between research design and research validity, much of the EBM effort has centered on refining "experimental" methodology, and the complexities of observational research have often been treated in an inappropriately dismissive manner. For advocates of EBM, an observational study is what you are relegated to as a second choice when you are unable to do an experimental study. The latter viewpoint may be true for evaluating new chemotherapeutic agents, but is unacceptable to pathologists, whose research advances are currently completely dependent on well-conducted observational research. Rather than succumb to randomization envy and accept EBM's assertion that observational research is second best, the challenge to AP is to develop and adhere to standards for observational research that will allow our patients to benefit from the full potential of this time tested approach to developing valid insights into disease.

Major Changes in AGU Publication Fees

NASA Astrophysics Data System (ADS)

Cook, Bill

2010-12-01

Effective with any manuscript submitted after 31 December 2010, AGU is eliminating color charges in all formats. At the same time that we eliminate color charges, we are simplifying publication fees. Articles published in Journal of Geophysical Research; Geochemistry, Geophysics, Geosystems; and Radio Science will each have a flat fee of $1000, and Geophysical Research Letters (GRL) articles will each have a flat fee of $500. These prices represent a small drop from the average cost currently paid by authors. We will retain the excess page charges for full articles longer than 13 pages (including Water Resources Research) and 4 pages for letters, comments, and replies. This simplification means we can streamline the “calculator” authors must use when submitting manuscripts to AGU.

Entamoeba histolytica: a snapshot of current research and methods for genetic analysis

PubMed Central

Morf, Laura; Singh, Upinder

2012-01-01

Entamoeba histolytica represents one of the leading causes of parasitic death worldwide. Although identified as the causative agent of amebiasis since 1875, the molecular mechanisms by which the parasite causes disease are still not fully understood. Studying Entamoeba reveals insights into a eukaryotic cell that differs in many ways from better-studied model organisms. Thus, much can be learned from this protozoan parasite on evolution, cell biology and RNA biology. In this review we discuss selected research highlights in Entamoeba research and focus on the development of molecular biological techniques to study this pathogen. We end by highlighting some of the many questions that remain to be answered in order to fully understand this important human pathogen. PMID:22664276

A shore-based preliminary survey of marine ribbon worms (Nemertea) from the Caribbean coast of Colombia

PubMed Central

Gonzalez-Cueto, Jaime; Quiroga, Sigmer; Norenburg, Jon

2014-01-01

Abstract A checklist of benthic ribbon worm species from the Caribbean coast of Colombia is presented, including synonyms, distributions, a photographic record, and the main morphologic characters of each species for a rapid identification. This is the first research focused broadly on nemerteans in Colombia. 54 specimens of nemerteans were hand-collected from the rocky littoral of two different localities, and identified according to personal experience and specialist literature. 13 species were found; of which 11 represent new records for the country. These species belong to eight different traditionally used families: Tubulanidae, Valenciniidae, Lineidae, Amphiporidae, Cratenemertidae, Emplectonematidae, Drepanophoridae and Ototyphlonemertidae. The most common and abundant species was Dushia atra. The biodiversity of nemerteans in Colombia seems to overlap with the nemertean fauna from Florida and Brazil, explained by the convergence of the North Brazil Current, Guiana Current, Caribbean Currents and the Panama-Colombia Contracurrent in the sampled region. The results of this work suggest that the Caribbean coast of Colombia is a region with a high diversity of nemerteans, and provide important taxonomic data for environmental assessments and future biological research. PMID:25317057

Speech Alarms Pilot Study

NASA Technical Reports Server (NTRS)

Sandor, A.; Moses, H. R.

2016-01-01

Currently on the International Space Station (ISS) and other space vehicles Caution & Warning (C&W) alerts are represented with various auditory tones that correspond to the type of event. This system relies on the crew's ability to remember what each tone represents in a high stress, high workload environment when responding to the alert. Furthermore, crew receive a year or more in advance of the mission that makes remembering the semantic meaning of the alerts more difficult. The current system works for missions conducted close to Earth where ground operators can assist as needed. On long duration missions, however, they will need to work off-nominal events autonomously. There is evidence that speech alarms may be easier and faster to recognize, especially during an off-nominal event. The Information Presentation Directed Research Project (FY07-FY09) funded by the Human Research Program included several studies investigating C&W alerts. The studies evaluated tone alerts currently in use with NASA flight deck displays along with candidate speech alerts. A follow-on study used four types of speech alerts to investigate how quickly various types of auditory alerts with and without a speech component - either at the beginning or at the end of the tone - can be identified. Even though crew were familiar with the tone alert from training or direct mission experience, alerts starting with a speech component were identified faster than alerts starting with a tone. The current study replicated the results from the previous study in a more rigorous experimental design to determine if the candidate speech alarms are ready for transition to operations or if more research is needed. Four types of alarms (caution, warning, fire, and depressurization) were presented to participants in both tone and speech formats in laboratory settings and later in the Human Exploration Research Analog (HERA). In the laboratory study, the alerts were presented by software and participants were asked to identify the alert as quickly and as accurately as possible. Reaction time and accuracy were measured. Participants identified speech alerts significantly faster than tone alerts. The HERA study investigated the performance of participants in a flight-like environment. Participants were instructed to complete items on a task list and respond to C&W alerts as they occurred. Reaction time and accuracy were measured to determine if the benefits of speech alarms are still present in an applied setting.

Description and Evaluation of a Measurement Technique for Assessment of Performing Gender

PubMed Central

Harris, Kathleen Mullan; Halpern, Carolyn Tucker

2016-01-01

The influence of masculinity and femininity on behaviors and outcomes has been extensively studied in social science research using various measurement strategies. In the present paper, we describe and evaluate a measurement technique that uses existing survey items to capture the extent to which an individual behaves similarly to their same-gender peers. We use data from the first four waves of The National Longitudinal Study of Adolescent to Adult Health (Add Health), a nationally representative sample of adolescents (age 12–18) in the United States who were re-interviewed at ages 13–19, 18–26, and 24–32. We estimate split-half reliability and provide evidence that supports the validity of this measurement technique. We demonstrate that the resulting measure does not perform as a trait measure and is associated with involvement in violent fights, a pattern consistent with theory and empirical findings. This measurement technique represents a novel approach for gender researchers with the potential for expanding our current knowledge base. PMID:28630528

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.

PubMed

Nae, S; Bordeianu, I; Stăncioiu, A T; Antohi, N

2013-01-01

Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into different cell types through differentiation. The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only in 2002, stem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous. Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures. Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Observations of synaptic structures: origins of the neuron doctrine and its current status

PubMed Central

Guillery, R.W

2004-01-01

The neuron doctrine represents nerve cells as polarized structures that contact each other at specialized (synaptic) junctions and form the developmental, functional, structural and trophic units of nervous systems. The doctrine provided a powerful analytical tool in the past, but is now seldom used in educating neuroscientists. Early observations of, and speculations about, sites of neuronal communication, which were made in the early 1860s, almost 30 years before the neuron doctrine was developed, are presented in relation to later accounts, particularly those made in support of, or opposition to, the neuron doctrine. These markedly differing accounts are considered in relation to limitations imposed by preparative and microscopical methods, and are discussed briefly as representing a post-Darwinian, reductionist view, on the one hand, opposed to a holistic view of mankind as a special part of creation, on the other. The widely misunderstood relationship of the neuron doctrine to the cell theory is discussed, as is the degree to which the neuron doctrine is still strictly applicable to an analysis of nervous systems. Current research represents a ‘post-neuronist’ era. The neuron doctrine provided a strong analytical approach in the past, but can no longer be seen as central to contemporary advances in neuroscience. PMID:16147523

The 2016 Academic Emergency Medicine Consensus Conference, Shared Decision Making in the Emergency Department: Development of a Policy-relevant Patient-centered Research Agenda May 10, 2016, New Orleans, LA.

PubMed

Grudzen, Corita R; Anderson, Jana R; Carpenter, Christopher R; Hess, Erik P

2016-12-01

Shared decision making in emergency medicine has the potential to improve the quality, safety, and outcomes of emergency department (ED) patients. Given that the ED is the gateway to care for patients with a variety of illnesses and injuries and the safety net for patients otherwise unable to access care, shared decision making in the ED is relevant to numerous disciplines and the interests of the United States (U.S.) public. On May 10, 2016 the 16th annual Academic Emergency Medicine (AEM) consensus conference, "Shared Decision Making: Development of a Policy-Relevant Patient-Centered Research Agenda" was held in New Orleans, Louisiana. During this one-day conference clinicians, researchers, policy-makers, patient and caregiver representatives, funding agency representatives, trainees, and content experts across many areas of medicine interacted to define high priority areas for research in 1 of 6 domains: 1) diagnostic testing; 2) policy, 3) dissemination/implementation and education, 4) development and testing of shared decision making approaches and tools in practice, 5) palliative care and geriatrics, and 6) vulnerable populations and limited health literacy. This manuscript describes the current state of shared decision making in the ED context, provides an overview of the conference planning process, the aims of the conference, the focus of each respective breakout session, the roles of patient and caregiver representatives and an overview of the conference agenda. The results of this conference published in this issue of AEM provide an essential summary of the future research priorities for shared decision making to increase quality of care and patient-centered outcomes. © 2016 by the Society for Academic Emergency Medicine.

Computers for real time flight simulation: A market survey

NASA Technical Reports Server (NTRS)

Bekey, G. A.; Karplus, W. J.

1977-01-01

An extensive computer market survey was made to determine those available systems suitable for current and future flight simulation studies at Ames Research Center. The primary requirement is for the computation of relatively high frequency content (5 Hz) math models representing powered lift flight vehicles. The Rotor Systems Research Aircraft (RSRA) was used as a benchmark vehicle for computation comparison studies. The general nature of helicopter simulations and a description of the benchmark model are presented, and some of the sources of simulation difficulties are examined. A description of various applicable computer architectures is presented, along with detailed discussions of leading candidate systems and comparisons between them.

Plant Immunity Inducer Development and Application.

PubMed

Dewen, Qiu; Yijie, Dong; Yi, Zhang; Shupeng, Li; Fachao, Shi

2017-05-01

Plant immunity inducers represent a new and rapidly developing field in plant-protection research. In this paper, we discuss recent research on plant immunity inducers and their development and applications in China. Plant immunity inducers include plant immunity-inducing proteins, chitosan oligosaccharides, and microbial inducers. These compounds and microorganisms can trigger defense responses and confer disease resistance in plants. We also describe the mechanisms of plant immunity inducers and how they promote plant health. Furthermore, we summarize the current situation in plant immunity inducer development in China and the global marketplace. Finally, we also deeply analyze the development trends and application prospects of plant immunity inducers in environmental protection and food safety.

Notes on the 1978 summer study program on dynamo models of geomagnetism in geophysical fluid dynamics at the Woods Hole Oceanographic Institution. Technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malkus, W.V.R.; Thayer, M.

1978-11-01

This volume contains the manuscripts of research lectures by the eleven fellows of the summer program. Five of the lectures overlap significantly with the central summer theme of geomagnetism. The other six lectures cover a broad range of current G.F.D. topics from collective instability to strange attractors. Several of these research efforts are quite polished and probably will appear in journals soon. The middle half represent reports of sound progress on studies of thesis calibre. A few of the lectures report on only the very first consequences of a novel idea.

Operational and Research Musculoskeletal Summit: Summit Recommendations

NASA Technical Reports Server (NTRS)

Scheuring, Richard A.; Walton, Marlei; Davis-Street, Janis; Smaka, Todd J.; Griffin, DeVon

2006-01-01

The Medical Informatics and Health Care Systems group in the Office of Space Medicine at NASA Johnson Space Center (JSC) has been tasked by NASA with improving overall medical care on the International Space Station (ISS) and providing insights for medical care for future exploration missions. To accomplish this task, a three day Operational and Research Musculoskeletal Summit was held on August 23-25th, 2005 at Space Center Houston. The purpose of the summit was to review NASA#s a) current strategy for preflight health maintenance and injury screening, b) current treatment methods in-flight, and c) risk mitigation strategy for musculoskeletal injuries or syndromes that could occur or impact the mission. Additionally, summit participants provided a list of research topics NASA should consider to mitigate risks to astronaut health. Prior to the summit, participants participated in a web-based pre-summit forum to review the NASA Space Medical Conditions List (SMCL) of musculoskeletal conditions that may occur on ISS as well as the resources currently available to treat them. Data from the participants were compiled and integrated with the summit proceedings. Summit participants included experts from the extramural physician and researcher communities, and representatives from NASA Headquarters, the astronaut corps, JSC Medical Operations and Human Adaptations and Countermeasures Offices, Glenn Research Center Human Research Office, and the Astronaut Strength, Conditioning, and Reconditioning (ASCR) group. The recommendations in this document are based on a summary of summit discussions and the best possible evidence-based recommendations for musculoskeletal care for astronauts while on the ISS, and include recommendati ons for exploration class missions.

EuFishBioMed (COST Action BM0804): A European Network to Promote the Use of Small Fishes in Biomedical Research

PubMed Central

Bally-Cuif, Laure; Kelsh, Robert; Beis, Dimitris; Mione, Marina; Panula, Pertti; Figueras, Antonio; Gothilf, Yoav; Brösamle, Christian; Geisler, Robert; Knedlitschek, Gudrun

2012-01-01

Abstract Small fresh water fishes such as the zebrafish (Danio rerio) have become important model organisms for biomedical research. They currently represent the best vertebrate embryo models in which it is possible to derive quantitative data on gene expression, signaling events, and cell behavior in real time in the living animal. Relevant phenotypes in fish mutants are similar to those of other vertebrate models and human diseases. They can be analyzed in great detail and much faster than in mammals. In recent years, approximately 2500 genetically distinct fish lines have been generated by European research groups alone. Their potential, including their possible use by industry, is far from being exploited. To promote zebrafish research in Europe, EuFishBioMed was founded and won support by the EU COST programme (http://www.cost.esf.org/). The main objective of EuFishBioMed is to establish a platform of knowledge exchange for research on small fish models with a strong focus on widening its biomedical applications and an integration of European research efforts and resources. EuFishBioMed currently lists more than 300 member laboratories in Europe, offers funding for short-term laboratory visits, organizes and co-sponsors meetings and workshops, and has successfully lobbied for the establishment of a European Zebrafish Resource Centre. To maintain this network in the future, beyond the funding period of the COST Action, we are currently establishing the European Society for Fish Models in Biology and Medicine. PMID:22537014

Empathic and Self-Regulatory Processes Governing Doping Behavior

PubMed Central

Boardley, Ian D.; Smith, Alan L.; Mills, John P.; Grix, Jonathan; Wynne, Ceri

2017-01-01

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- (n = 195) and individual- (n = 169) sport athletes and hardcore- (n = 125) and corporate- (n = 121) gym exercisers representing both genders (nmale = 371; nfemale = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts. PMID:29018370

Empathic and Self-Regulatory Processes Governing Doping Behavior.

PubMed

Boardley, Ian D; Smith, Alan L; Mills, John P; Grix, Jonathan; Wynne, Ceri

2017-01-01

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- ( n = 195) and individual- ( n = 169) sport athletes and hardcore- ( n = 125) and corporate- ( n = 121) gym exercisers representing both genders ( n male = 371; n female = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts.

General internal medicine at the crossroads of prosperity and despair: caring for patients with chronic diseases in an aging society.

PubMed

Larson, E B

2001-05-15

During the past quarter century, general internal medicine has emerged as a vital discipline. In the realm of patient care, it is the integrating discipline par excellence. Ironically, as general internists face the challenge of integrating advances of dizzying speed and complexity, and as their clinical practice becomes increasingly effective, it has become much more difficult for them to earn a living. General internists find themselves at the crossroads of prosperity and despair. Although general medicine research leads the research agenda in many departments of medicine, it is particularly vulnerable. The necessary multidisciplinary "programmatic" infrastructure is expensive, and results often take many years to obtain, particularly in the study of chronic disease. The educational environment in many institutions is particularly difficult for general medicine, both because the current emphasis on technical skills obscures patients' and learners' real needs and because complex patients on general medicine services are now so ill and their turnover so rapid. General internal medicine and geriatrics are synergistic, especially in today's marketplace. A focus on geriatric medicine could help general medicine continue to flourish. General internists are ideally suited to the integrated care of elderly patients with multiple problems, research opportunities are enormous in the geriatric population, and the teaching of geriatrics requires a high level of generalist skills. Problems that plague current generalist practice have unique significance to older patients. Organizations that represent general internists would do well to join forces with many other advocacy groups, especially those representing the interests of elderly patients and geriatric medicine.

The cancer secretome, current status and opportunities in the lung, breast and colorectal cancer context.

PubMed

Schaaij-Visser, Tieneke B M; de Wit, Meike; Lam, Siu W; Jiménez, Connie R

2013-11-01

Despite major improvements on the knowledge and clinical management, cancer is still a deadly disease. Novel biomarkers for better cancer detection, diagnosis and treatment prediction are urgently needed. Proteins secreted, shed or leaking from the cancer cell, collectively termed the cancer secretome, are promising biomarkers since they might be detectable in blood or other biofluids. Furthermore, the cancer secretome in part represents the tumor microenvironment that plays a key role in tumor promoting processes such as angiogenesis and invasion. The cancer secretome, sampled as conditioned medium from cell lines, tumor/tissue interstitial fluid or tumor proximal body fluids, can be studied comprehensively by nanoLC-MS/MS-based approaches. Here, we outline the importance of current cancer secretome research and describe the mass spectrometry-based analysis of the secretome. Further, we provide an overview of cancer secretome research with a focus on the three most common cancer types: lung, breast and colorectal cancer. We conclude that the cancer secretome research field is a young, but rapidly evolving research field. Up to now, the focus has mainly been on the discovery of novel promising secreted cancer biomarker proteins. An interesting finding that merits attention is that in cancer unconventional secretion, e.g. via vesicles, seems increased. Refinement of current approaches and methods and progress in clinical validation of the current findings are vital in order to move towards applications in cancer management. This article is part of a Special Issue entitled: An Updated Secretome. Copyright © 2013 Elsevier B.V. All rights reserved.

Toward Improved Land Surface Initialization in Support of Regional WRF Forecasts at the Kenya Meteorological Service (KMS)

NASA Technical Reports Server (NTRS)

Case, Jonathan L.; Mungai, John; Sakwa, Vincent; Kabuchanga, Eric; Zavodsky, Bradley T.; Limaye, Ashutosh S.

2014-01-01

SPoRT/SERVIR/RCMRD/KMS Collaboration: Builds off strengths of each organization. SPoRT: Transition of satellite, modeling and verification capabilities; SERVIR-Africa/RCMRD: International capacity-building expertise; KMS: Operational organization with regional weather forecasting expertise in East Africa. Hypothesis: Improved land-surface initialization over Eastern Africa can lead to better temperature, moisture, and ultimately precipitation forecasts in NWP models. KMS currently initializes Weather Research and Forecasting (WRF) model with NCEP/Global Forecast System (GFS) model 0.5-deg initial / boundary condition data. LIS will provide much higher-resolution land-surface data at a scale more representative to regional WRF configuration. Future implementation of real-time NESDIS/VIIRS vegetation fraction to further improve land surface representativeness.

Graphic products used in the evaluation of traditional and emerging remote sensing technologies for the detection of fugitive contamination at selected superfund hazardous waste sites

USGS Publications Warehouse

Slonecker, E. Terrence; Fisher, Gary B.

2011-01-01

This report presents the overhead imagery and field sampling results used to prepare U.S. Geological Survey Open-File Report 2011-1050, 'Evaluation of Traditional and Emerging Remote Sensing Technologies for the Detection of Fugitive Contamination at Selected Superfund Hazardous Waste Sites'. These graphic products were used in the evaluation of remote sensing technology in postclosure monitoring of hazardous waste sites and represent an ongoing research effort. Soil sampling results presented here were accomplished with field portable x-ray fluoresence (XRF) technology and are used as screening tools only representing the current conditions of metals and other contaminants at selected Superfund hazardous waste sites.

On inter-tidal transport equation

USGS Publications Warehouse

Cheng, Ralph T.; Feng, Shizuo; Pangen, Xi

1989-01-01

The transports of solutes, sediments, nutrients, and other tracers are fundamental to the interactive physical, chemical, and biological processes in estuaries. The characteristic time scales for most estuarine biological and chemical processes are on the order of several tidal cycles or longer. To address the long-term transport mechanism meaningfully, the formulation of an inter-tidal conservation equation is the main subject of this paper. The commonly used inter-tidal conservation equation takes the form of a convection-dispersion equation in which the convection is represented by the Eulerian residual current, and the dispersion terms are due to the introduction of a Fickian hypothesis, unfortunately, the physical significance of this equation is not clear, and the introduction of a Fickian hypothesis is at best an ad hoc approximation. Some recent research results on the Lagrangian residual current suggest that the long-term transport problem is more closely related to the Lagrangian residual current than to the Eulerian residual current. With the aid of additional insight of residual current, the inter-tidal transport equation has been reformulated in this paper using a small perturbation method for a weakly nonlinear tidal system. When tidal flows can be represented by an M2 system, the new intertidal transport equation also takes the form of a convective-dispersion equation without the introduction of a Fickian hypothesis. The convective velocity turns out to be the first order Lagrangian residual current (the sum of the Eulerian residual current and the Stokes’ drift), and the correlation terms take the form of convection with the Stokes’ drift as the convective velocity. The remaining dispersion terms are perturbations of lower order solution to higher order solutions due to shear effect and turbulent mixing.

Recapturing Graphite-Based Fuel Element Technology for Nuclear Thermal Propulsion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trammell, Michael P; Jolly, Brian C; Miller, James Henry

ORNL is currently recapturing graphite based fuel forms for Nuclear Thermal Propulsion (NTP). This effort involves research and development on materials selection, extrusion, and coating processes to produce fuel elements representative of historical ROVER and NERVA fuel. Initially, lab scale specimens were fabricated using surrogate oxides to develop processing parameters that could be applied to full length NTP fuel elements. Progress toward understanding the effect of these processing parameters on surrogate fuel microstructure is presented.

Intravenous Artesunate: The New Generation of Lifesaving Treatment for Severe Malaria in the Warfighter

DTIC Science & Technology

2006-11-01

certain electrocardiac disturbances and may soon cease to be available in the U.S. Artemisinins are antimalarials derived from the Chinese herb... artemisinins have been used in much of the world and represent an improvement in efficacy and safety for severe malaria. There are currently no FDA...approved intravenous artemisinin products available in the U.S. The Walter Reed Army Institute of Research has a long history with the artemisinins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kostka, Joel E.

Summary of Results to Date: Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), Florida State University (FSU), and the University of Tennessee. ORNL will serve as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project was initiated in November, 2004, in the Integrative Studies Element of the NABIR program. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

Biomaterials for Tissue Engineering

PubMed Central

Lee, Esther J.; Kasper, F. Kurtis; Mikos, Antonios G.

2013-01-01

Biomaterials serve as an integral component of tissue engineering. They are designed to provide architectural framework reminiscent of native extracellular matrix in order to encourage cell growth and eventual tissue regeneration. Bone and cartilage represent two distinct tissues with varying compositional and mechanical properties. Despite these differences, both meet at the osteochondral interface. This article presents an overview of current biomaterials employed in bone and cartilage applications, discusses some design considerations, and alludes to future prospects within this field of research. PMID:23820768

Improving the Laboratory Experience for America's High School Students. Hearing before the Subcommittee on Research and Science Education of the Committee on Science and Technology, House of Representatives, One Hundred Tenth Congress, First Session (March 8, 2007). Serial Number 110-9

ERIC Educational Resources Information Center

US House of Representatives, 2007

2007-01-01

This hearing discussed how lack of coordination between laboratory exercises and classroom lectures, inadequately trained teachers, languishing facilities, and current high school organization diminish the value these exercises can have or prohibit them all together, and highlighted how a strong hands-on experience can create scientifically…

[A first analysis of research on social determinants of health in Mexico: 2005-2012].

PubMed

Salgado-de Snyder, V Nelly; Guerra-y Guerra, Germán

2014-01-01

To examine the research on social determinants of health (SDH) produced in Mexico during the period 2005-2012, based on the characterization of the national health research system and the scientific production on this topic. Two-stage analyses: Review of Mexican documents and official sources on health research and systematic bibliographic review of the literature on SDH. Although SDH were mentioned in the Specific Action Plan for Health Research 2007-2012, they are not implemented in strategies and goals, as the emphasis is put mostly in infrastructure and administrative aspects of research. In the period studied, 145 articles were published on SDH topics such as health conditions, health systems and nutrition and obesity. In spite of the availability of research on SDH in Mexico, the operationalization of such findings into health policies has not been possible. The current Sectorial Program on Health 2013-2018 represents a window of opportunity to position research findings that promote health equity policies.

Recent research related to juvenile sex offending: findings and directions for further research.

PubMed

Malin, H Martin; Saleh, Fabian M; Grudzinskas, Albert J

2014-04-01

Serious scholarly inquiry into juvenile sex offending represents a relatively new field, dating from the mid 1940s. During the next 4 decades, a mere handful of articles exploring aspects of juvenile sex offending were added to the available literature. By the 1980s, however, the literature began to increase rapidly, a trend that continues today. The purpose of this article is a focused review of the juvenile sex offender literature cited in PubMed over the last 5 years (2009-2013). The authors have chosen studies that will bring readers up to date on research they believe impacts our current understanding of best practices in the management of juvenile sex offending. For convenience, our review is organized into topical categories including research into characteristics and typologies of juvenile sex offenders, risk assessment and recidivism, assessment and treatment, the ongoing debate about mandatory registration of sex offenders as it applies to juveniles, and other thought provoking studies that do not fit neatly into the aforementioned categories. The studies included contain findings that both reinforce and challenge currently held notions about best practices concerning treatment and public policy, suggesting that our knowledge of the field continues to evolve in important ways.

New insights into the placebo and nocebo responses.

PubMed

Enck, Paul; Benedetti, Fabrizio; Schedlowski, Manfred

2008-07-31

In modern medicine, the placebo response or placebo effect has often been regarded as a nuisance in basic research and particularly in clinical research. The latest scientific evidence has demonstrated, however, that the placebo effect and the nocebo effect, the negative effects of placebo, stem from highly active processes in the brain that are mediated by psychological mechanisms such as expectation and conditioning. These processes have been described in some detail for many diseases and treatments, and we now know that they can represent both strength and vulnerability in the course of a disease as well as in the response to a therapy. However, recent research and current knowledge raise several issues that we shall address in this review. We will discuss current neurobiological models like expectation-induced activation of the brain reward circuitry, Pavlovian conditioning, and anxiety mechanisms of the nocebo response. We will further explore the nature of the placebo responses in clinical trials and address major questions for future research such as the relationship between expectations and conditioning in placebo effects, the existence of a consistent brain network for all placebo effects, the role of gender in placebo effects, and the impact of getting drug-like effects without drugs.

The Ethics of HIV “Cure” Research: What Can We Learn from Consent Forms?

PubMed Central

2015-01-01

Abstract The advent of HIV “cure” research has generated enormous attention, but also concern about its potential to engender false hope, leading to overestimation of benefits and underestimation of risks, and about recruiting relatively healthy participants to studies with uncertain or serious risks. Currently, little is known about potential ethical problems in the ways that informed consent for HIV cure research is described to potential participants. As a first step to address this question, early phase, HIV “cure” research consent forms were analyzed to assess how study aims and potential risks and benefits are presented. Thirteen consent forms from a diverse group of clinical studies were selected to represent the major categories of cure research, including 11 interventional (gene transfer, vaccine intensification, treatment interruption, and latency reversing) and two observational. Consent forms were coded using seven categories, abstracting data on study purpose and design, participant selection criteria, presentation of risks and benefits of participation, and potential return of research results. Findings demonstrate variation and deficiencies that merit attention, but that can largely be addressed by turning to existing guidance about early phase research and specific study designs from other research contexts. The most challenging of these is ensuring that clear, specific, and consistent language is used to describe study aims, risks, benefits, and possible return of results. Informed consent for HIV “cure” research represents an opportunity to apply relevant existing guidance, measure the effectiveness of its application, and develop standardized best-practice policies for consent forms and processes. PMID:25406579

A review of contrast pattern based data mining

NASA Astrophysics Data System (ADS)

Zhu, Shiwei; Ju, Meilong; Yu, Junfeng; Cai, Binlei; Wang, Aiping

2015-07-01

Contrast pattern based data mining is concerned with the mining of patterns and models that contrast two or more datasets. Contrast patterns can describe similarities or differences between the datasets. They represent strong contrast knowledge and have been shown to be very successful for constructing accurate and robust clusters and classifiers. The increasing use of contrast pattern data mining has initiated a great deal of research and development attempts in the field of data mining. A comprehensive revision on the existing contrast pattern based data mining research is given in this paper. They are generally categorized into background and representation, definitions and mining algorithms, contrast pattern based classification, clustering, and other applications, the research trends in future. The primary of this paper is to server as a glossary for interested researchers to have an overall picture on the current contrast based data mining development and identify their potential research direction to future investigation.

Overview of Stirling Technology Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Schifer, Nicholas A.; Williams, Zachary D.; Metscher, Jonathan F.

2016-01-01

Stirling Radioisotope Power Systems (RPSs) are under development to provide power on future space science missions where robotic spacecraft will orbit, fly by, land, or rove using less than a quarter of the plutonium the currently available RPS uses to produce about the same power. NASA Glenn Research Center's newly formulated Stirling Cycle Technology Development Project (SCTDP) continues development of Stirling-based systems and subsystems, which include a flight-like generator and related housing assembly, controller, and convertors. The project also develops less mature technologies under Stirling Technology Research, with a focus on demonstration in representative environments to increase the technology readiness level (TRL). Matured technologies are evaluated for selection in future generator designs. Stirling Technology Research tasks focus on a wide variety of objectives, including increasing temperature capability to enable new environments, reducing generator mass and/or size, improving reliability and system fault tolerance, and developing alternative designs. The task objectives and status are summarized.

ORNL Sustainable Campus Initiative

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halford, Christopher K

2012-01-01

The research conducted at Oak Ridge National Laboratory (ORNL) spans many disciplines and has the potential for far-reaching impact in many areas of everyday life. ORNL researchers and operations staff work on projects in areas as diverse as nuclear power generation, transportation, materials science, computing, and building technologies. As the U.S. Department of Energy s (DOE) largest science and energy research facility, ORNL seeks to establish partnerships with industry in the development of innovative new technologies. The primary focus of this current research deals with developing technologies which improve or maintain the quality of life for humans while reducing themore » overall impact on the environment. In its interactions with industry, ORNL serves as both a facility for sustainable research, as well as a representative of DOE to the private sector. For these reasons it is important that the everyday operations of the Laboratory reflect a dedication to the concepts of stewardship and sustainability.« less

Overview of Stirling Technology Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Schifer, Nicholas A.; Williams, Zachary D.; Metscher, Jonathan F.

2015-01-01

Stirling Radioisotope Power Systems (RPS) are under development to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove using less than a quarter of the plutonium the currently available RPS uses to produce about the same power. Glenn Research Center's (GRC's) newly formulated Stirling Cycle Technology Development Project (SCTDP) continues development of Stirling-based systems and subsystems, which include a flight-like generator and related housing assembly, controller, and convertors. The project also develops less mature technologies under Stirling Technology Research, with a focus on demonstration in representative environments to increase the technology readiness level (TRL). Matured technologies are evaluated for selection in future generator designs. Stirling Technology Research tasks focus on a wide variety of objectives, including increasing temperature capability to enable new environments, reducing generator mass and/or size, improving reliability or system fault tolerance, and developing alternative designs. The task objectives and status are summarized.

Insufficient evidence to support separate BMI definitions for obesity in children and adolescents from south Asian ethnic groups in the UK.

PubMed

Viner, R M; Cole, Tim J; Fry, T; Gupta, S; Kinra, S; McCarthy, D; Saxena, S; Taylor, S; Wells, J C K; Whincup, P; Zaman, M J S

2010-04-01

Re-evaluation of adult obesity thresholds in some ethnic groups has led to the questioning of childhood obesity thresholds. An expert group was convened to examine the representativeness of childhood obesity definitions, evidence for ethnic differences in body composition in UK children and the extent of misclassification of adiposity by current body mass index (BMI) thresholds in south Asian and black groups. The group concluded that the current International Obesity Task Force (IOTF) definitions remained the most appropriate for use in the United Kingdom, but further research was needed on the relationship of body shape, fat mass, metabolic markers and ethnicity in children and adolescents.

Hydrogen storage and fuel cells

NASA Astrophysics Data System (ADS)

Liu, Di-Jia

2018-01-01

Global warming and future energy supply are two major challenges facing American public today. To overcome such challenges, it is imperative to maximize the existing fuel utilization with new conversion technologies while exploring alternative energy sources with minimal environmental impact. Hydrogen fuel cell represents a next-generation energy-efficient technology in transportation and stationary power productions. In this presentation, a brief overview of the current technology status of on-board hydrogen storage and polymer electrolyte membrane fuel cell in transportation will be provided. The directions of the future researches in these technological fields, including a recent "big idea" of "H2@Scale" currently developed at the U. S. Department of Energy, will also be discussed.

Mild Normobaric Hypoxia Exposure for Human-Autonomy System Testing

NASA Technical Reports Server (NTRS)

Stephens, Chad L.; Kennedy, Kellie D.; Crook, Brenda L.; Williams, Ralph A.; Schutte, Paul

2017-01-01

An experiment investigated the impact of normobaric hypoxia induction on aircraft pilot performance to specifically evaluate the use of hypoxia as a method to induce mild cognitive impairment to explore human-autonomous systems integration opportunities. Results of this exploratory study show that the effect of 15,000 feet simulated altitude did not induce cognitive deficits as indicated by performance on written, computer-based, or simulated flight tasks. However, the subjective data demonstrated increased effort by the human test subject pilots to maintain equivalent performance in a flight simulation task. This study represents current research intended to add to the current knowledge of performance decrement and pilot workload assessment to improve automation support and increase aviation safety.

Management of Candida biofilms: state of knowledge and new options for prevention and eradication.

PubMed

Bujdáková, Helena

2016-01-01

Biofilms formed by Candida species (spp.) on medical devices represent a potential health risk. The focus of current research is searching for new options for the treatment and prevention of biofilm-associated infections using different approaches including modern nanotechnology. This review summarizes current information concerning the most relevant resistance/tolerance mechanisms to conventional drugs and a role of additional factors contributing to these phenomena in Candida spp. (mostly Candida albicans). Additionally, it provides an information update in prevention and eradication of a Candida biofilm including experiences with 'lock' therapy, potential utilization of small molecules in biomedical applications, and perspectives of using photodynamic inactivation in the control of a Candida biofilm.

Somatic Treatments for Mood Disorders

PubMed Central

Rosa, Moacyr A; Lisanby, Sarah H

2012-01-01

Somatic treatments for mood disorders represent a class of interventions available either as a stand-alone option, or in combination with psychopharmacology and/or psychotherapy. Here, we review the currently available techniques, including those already in clinical use and those still under research. Techniques are grouped into the following categories: (1) seizure therapies, including electroconvulsive therapy and magnetic seizure therapy, (2) noninvasive techniques, including repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and cranial electric stimulation, (3) surgical approaches, including vagus nerve stimulation, epidural electrical stimulation, and deep brain stimulation, and (4) technologies on the horizon. Additionally, we discuss novel approaches to the optimization of each treatment, and new techniques that are under active investigation. PMID:21976043

Social Media Technology and Public Health in Ontario: Findings from a Planning Meeting Exploring Current Practices and Future Research Directions.

PubMed

Booth, Richard; McMurray, Josephine; Regan, Sandra; Kothari, Anita; Donelle, Lorie; McBride, Susan; Sobel, Annette; Hall, Jodi; Fraser, Robert; Foisey, Lyndsay

2017-01-01

In the province of Ontario, many of the public health units (PHUs) now possess and use social media as part of their daily health promotion and communication operations. To explore this topic, a planning meeting was held to generate deeper insights toward the use of these forms of technology for preventative services delivery. The planning meeting was held with 50 participants, comprising representatives from 20 of the 36 PHUs in Ontario, interested academics, students and government representatives. A nominal group technique (NGT) was used to build consensus related to future research needs, as related to public health and social media. Participants generated a range of insights around the use of social media, including the need for: leadership buy-in and resource allocation; social media policy and governance structure; performance measurement and evaluation; practices related to engagement with program recipients and addressing the lack of resources faced by many health units. Future research priorities were also generated, related to evaluating the cost-benefit of social media activities and understanding behaviour change implications. Further research is needed to evaluate the functionality, leadership and competency requirements and impact(s) of these new forms of health communication technology within public health service delivery. Copyright © 2017 Longwoods Publishing.

Need for more research on and health interventions for transgender people.

PubMed

Ortiz-Martínez, Yeimer; Ríos-González, Carlos Miguel

2017-04-01

Background Recently, lesbian, gay, bisexual, and transgender (LGBT) scientific production is growing, but transgender (TG) people is less considered in the LGBT-related research, highlighting the lack of representative data on this neglected population. To assess the current status of scientific production on TG population, a bibliometric study was performed using the articles on TG people deposited in five databases, including PubMed/Medline, Scopus, Science Citation Index (SCI), Scientific Electronic Library Online (SciELO) and Latin American and Caribbean Health Sciences Literature (LILACS). The PubMed/Medline search retrieved 2370 documents, which represented 0.008% of all articles recorded in Medline. The Scopus search identified 4974 articles. At SCI, 2863 articles were identified. A search of the SciELO database identified 39 articles, whereas the LILACS search identified 44 articles. Most papers were from the US (57.59%), followed by Canada (5.15%), the UK (4.42%), Australia (3.19%), The Netherlands (2.46%) and Peru (1.83%). These six countries accounted for 74.6% of all scientific output. The findings indicate that the TG-related research is low, especially in low-income developing countries, where stigma and discrimination are common. More awareness, knowledge, and sensitivity in healthcare communities are needed to eliminate barriers in health attention and research in this population.

Nanotechnology in bone tissue engineering.

PubMed

Walmsley, Graham G; McArdle, Adrian; Tevlin, Ruth; Momeni, Arash; Atashroo, David; Hu, Michael S; Feroze, Abdullah H; Wong, Victor W; Lorenz, Peter H; Longaker, Michael T; Wan, Derrick C

2015-07-01

Nanotechnology represents a major frontier with potential to significantly advance the field of bone tissue engineering. Current limitations in regenerative strategies include impaired cellular proliferation and differentiation, insufficient mechanical strength of scaffolds, and inadequate production of extrinsic factors necessary for efficient osteogenesis. Here we review several major areas of research in nanotechnology with potential implications in bone regeneration: 1) nanoparticle-based methods for delivery of bioactive molecules, growth factors, and genetic material, 2) nanoparticle-mediated cell labeling and targeting, and 3) nano-based scaffold construction and modification to enhance physicochemical interactions, biocompatibility, mechanical stability, and cellular attachment/survival. As these technologies continue to evolve, ultimate translation to the clinical environment may allow for improved therapeutic outcomes in patients with large bone deficits and osteodegenerative diseases. Traditionally, the reconstruction of bony defects has relied on the use of bone grafts. With advances in nanotechnology, there has been significant development of synthetic biomaterials. In this article, the authors provided a comprehensive review on current research in nanoparticle-based therapies for bone tissue engineering, which should be useful reading for clinicians as well as researchers in this field. Copyright © 2015 Elsevier Inc. All rights reserved.

Substance use in the MSM population of New York City during the era of HIV/AIDS.

PubMed

Halkitis, Perry N; Pollock, James A; Pappas, Molly K; Dayton, Alex; Moeller, Robert W; Siconolfi, Daniel; Solomon, Todd

2011-01-01

This literature review considers the historical significance, emergence of, and interplay between the HIV and illicit drug use epidemics among gay, bisexual, and other men who have sex with men (MSM) in New York City (NYC). The continual rise in HIV infections in recent years among MSM, particularly among young MSM (YMSM), commands a need for the examination of the effectiveness of current HIV prevention strategies and a more comprehensive understanding of the complex biopsychosocial influences that place YMSM at risk. A chronological perspective of both the HIV and illicit drug use epidemics affecting NYC MSM is presented, followed by a review of the existing research on the synergistic relation between the two. Special consideration is given to the patterns and interconnectivity between HIV, substance use, and housing instability specific to YMSM, as they represent the demographic currently at greatest risk for HIV transmission in NYC. Thereafter, an overview of treatment research is provided. We conclude by offering recommendations for future research and best practices as we move forward in an attempt to reduce the incidence of HIV transmission.

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

PubMed Central

Swerdlow, Russell H.

2017-01-01

Decades of research indicate mitochondria from Alzheimer’s disease (AD) patients differ from those of non-AD individuals. Initial studies revealed structural differences, and subsequent studies showed functional deficits. Observations of structure and function changes prompted investigators to consider the consequences, significance, and causes of AD-related mitochondrial dysfunction. Currently, extensive research argues mitochondria may mediate, drive, or contribute to a variety of AD pathologies. The perceived significance of these mitochondrial changes continues to grow, and many currently believe AD mitochondrial dysfunction represents a reasonable therapeutic target. Debate continues over the origin of AD mitochondrial changes. Some argue amyloid-β (Aβ) induces AD mitochondrial dysfunction, a view that does not challenge the amyloid cascade hypothesis and that may in fact help explain that hypothesis. Alternatively, data indicate mitochondrial dysfunction exists independent of Aβ, potentially lies upstream of Aβ deposition, and suggest a primary mitochondrial cascade hypothesis that assumes mitochondrial pathology hierarchically supersedes Aβ pathology. Mitochondria, therefore, appear at least to mediate or possibly even initiate pathologic molecular cascades in AD. This review considers studies and data that inform this area of AD research. PMID:29036828

A Review of Current Neuromorphic Approaches for Vision, Auditory, and Olfactory Sensors

PubMed Central

Vanarse, Anup; Osseiran, Adam; Rassau, Alexander

2016-01-01

Conventional vision, auditory, and olfactory sensors generate large volumes of redundant data and as a result tend to consume excessive power. To address these shortcomings, neuromorphic sensors have been developed. These sensors mimic the neuro-biological architecture of sensory organs using aVLSI (analog Very Large Scale Integration) and generate asynchronous spiking output that represents sensing information in ways that are similar to neural signals. This allows for much lower power consumption due to an ability to extract useful sensory information from sparse captured data. The foundation for research in neuromorphic sensors was laid more than two decades ago, but recent developments in understanding of biological sensing and advanced electronics, have stimulated research on sophisticated neuromorphic sensors that provide numerous advantages over conventional sensors. In this paper, we review the current state-of-the-art in neuromorphic implementation of vision, auditory, and olfactory sensors and identify key contributions across these fields. Bringing together these key contributions we suggest a future research direction for further development of the neuromorphic sensing field. PMID:27065784

The Structure of Psychopathology: Toward an Expanded Quantitative Empirical Model

PubMed Central

Wright, Aidan G.C.; Krueger, Robert F.; Hobbs, Megan J.; Markon, Kristian E.; Eaton, Nicholas R.; Slade, Tim

2013-01-01

There has been substantial recent interest in the development of a quantitative, empirically based model of psychopathology. However, the majority of pertinent research has focused on analyses of diagnoses, as described in current official nosologies. This is a significant limitation because existing diagnostic categories are often heterogeneous. In the current research, we aimed to redress this limitation of the existing literature, and to directly compare the fit of categorical, continuous, and hybrid (i.e., combined categorical and continuous) models of syndromes derived from indicators more fine-grained than diagnoses. We analyzed data from a large representative epidemiologic sample (the 2007 Australian National Survey of Mental Health and Wellbeing; N = 8,841). Continuous models provided the best fit for each syndrome we observed (Distress, Obsessive Compulsivity, Fear, Alcohol Problems, Drug Problems, and Psychotic Experiences). In addition, the best fitting higher-order model of these syndromes grouped them into three broad spectra: Internalizing, Externalizing, and Psychotic Experiences. We discuss these results in terms of future efforts to refine emerging empirically based, dimensional-spectrum model of psychopathology, and to use the model to frame psychopathology research more broadly. PMID:23067258

Coupled Qubits for Next Generation Quantum Annealing: Improving Coherence

NASA Astrophysics Data System (ADS)

Weber, Steven; Samach, Gabriel; Hover, David; Rosenberg, Danna; Yoder, Jonilyn; Kim, David K.; Kerman, Andrew; Oliver, William D.

Quantum annealing is an optimization technique which potentially leverages quantum tunneling to enhance computational performance. Existing quantum annealers use superconducting flux qubits with short coherence times, limited primarily by the use of large persistent currents. Here, we examine an alternative approach, using flux qubits with smaller persistent currents and longer coherence times. We demonstrate tunable coupling, a basic building-block for quantum annealing, between two such qubits. Furthermore, we characterize qubit coherence as a function of coupler setting and investigate the effect of flux noise in the coupler loop on qubit coherence. Our results provide insight into the available design space for next-generation quantum annealers with improved coherence. This research was funded by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA) and by the Assistant Secretary of Defense for Research & Engineering under Air Force Contract No. FA8721-05-C-0002. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of ODNI, IARPA, or the US Government.

Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro.

PubMed

Knight, Eleanor; Przyborski, Stefan

2015-12-01

Research in mammalian cell biology often relies on developing in vitro models to enable the growth of cells in the laboratory to investigate a specific biological mechanism or process under different test conditions. The quality of such models and how they represent the behavior of cells in real tissues plays a critical role in the value of the data produced and how it is used. It is particularly important to recognize how the structure of a cell influences its function and how co-culture models can be used to more closely represent the structure of real tissue. In recent years, technologies have been developed to enhance the way in which researchers can grow cells and more readily create tissue-like structures. Here we identify the limitations of culturing mammalian cells by conventional methods on two-dimensional (2D) substrates and review the popular approaches currently available that enable the development of three-dimensional (3D) tissue models in vitro. There are now many ways in which the growth environment for cultured cells can be altered to encourage 3D cell growth. Approaches to 3D culture can be broadly categorized into scaffold-free or scaffold-based culture systems, with scaffolds made from either natural or synthetic materials. There is no one particular solution that currently satisfies all requirements and researchers must select the appropriate method in line with their needs. Using such technology in conjunction with other modern resources in cell biology (e.g. human stem cells) will provide new opportunities to create robust human tissue mimetics for use in basic research and drug discovery. Application of such models will contribute to advancing basic research, increasing the predictive accuracy of compounds, and reducing animal usage in biomedical science. © 2014 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.

Cancer Treatment–Related Cardiotoxicity: Current State of Knowledge and Future Research Priorities

PubMed Central

Adhikari, Bishow; Brell, Joanna; Davis, Myrtle; Desvigne-Nickens, Patrice; Freedman, Andrew; Minasian, Lori; Force, Thomas; Remick, Scot C.

2014-01-01

Cardiotoxicity resulting from direct myocyte damage has been a known complication of cancer treatment for decades. More recently, the emergence of hypertension as a clinically significant side effect of several new agents has been recognized as adversely affecting cancer treatment outcomes. With cancer patients living longer, in part because of treatment advances, these adverse events have become increasingly important to address. However, little is known about the cardiovascular pathogenic mechanisms associated with cancer treatment and even less about how to optimally prevent and manage short- and long-term cardiovascular complications, leading to improved patient safety and clinical outcomes. To identify research priorities, allocate resources, and establish infrastructure required to address cardiotoxicity associated with cancer treatment, the National Cancer Institute (NCI) and National Heart, Lung and Blood Institute (NHLBI) sponsored a two-day workshop, “Cancer treatment–related cardiotoxicity: Understanding the current state of knowledge and future research priorities,” in March 2013 in Bethesda, MD. Participants included leading oncology and cardiology researchers and health professionals, patient advocates and industry representatives, with expertise ranging from basic to clinical science. Attendees were charged with identifying research opportunities to advance the understanding of cancer treatment–related cardiotoxicity across basic and clinical science. This commentary highlights the key discussion points and overarching recommendations from that workshop. PMID:25210198

The Social Neuroscience of Interpersonal Emotions.

PubMed

Müller-Pinzler, Laura; Krach, Sören; Krämer, Ulrike M; Paulus, Frieder M

In our daily lives, we constantly engage in reciprocal interactions with other individuals and represent ourselves in the context of our surrounding social world. Within social interactions, humans often experience interpersonal emotions such as embarrassment, shame, guilt, or pride. How interpersonal emotions are processed on the neural systems level is of major interest for social neuroscience research. While the configuration of laboratory settings in general is constraining for emotion research, recent neuroimaging investigations came up with new approaches to implement socially interactive and immersive scenarios for the real-life investigation of interpersonal emotions. These studies could show that among other brain regions the so-called mentalizing network, which is typically involved when we represent and make sense of others' states of mind, is associated with interpersonal emotions. The anterior insula/anterior cingulate cortex network at the same time processes one's own bodily arousal during such interpersonal emotional experiences. Current research aimed to explore how we make sense of others' emotional states during social interactions and investigates the modulating factors of our emotional experiences during social interactions. Understanding how interpersonal emotions are processed on the neural systems level may yield significant implications for neuropsychiatric disorders that affect social behavior such as social anxiety disorders or autism.

Skidmore Clips of Neutral and Expressive Scenarios (SCENES): Novel dynamic stimuli for social cognition research.

PubMed

Schofield, Casey A; Weeks, Justin W; Taylor, Lea; Karnedy, Colten

2015-12-30

Social cognition research has relied primarily on photographic emotional stimuli. Such stimuli likely have limited ecological validity in terms of representing real world social interactions. The current study presents evidence for the validity of a new stimuli set of dynamic social SCENES (Skidmore Clips of Emotional and Neutral Expressive Scenarios). To develop these stimuli, ten undergraduate theater students were recruited to portray members of an audience. This audience was configured to display (seven) varying configurations of social feedback, ranging from unequivocally approving to unequivocally disapproving (including three different versions of balanced/neutral scenes). Validity data were obtained from 383 adult participants recruited from Amazon's Mechanical Turk. Each participant viewed three randomly assigned scenes and provided a rating of the perceived criticalness of each scene. Results indicate that the SCENES reflect the intended range of emotionality, and pairwise comparisons suggest that the SCENES capture distinct levels of critical feedback. Overall, the SCENES stimuli set represents a publicly available (www.scenesstimuli.com) resource for researchers interested in measuring social cognition in the presence of dynamic and naturalistic social stimuli. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

An empirical evaluation of the structure of DSM-IV personality disorders in a nationally representative sample: results of confirmatory factor analysis in the National Epidemiologic Survey on Alcohol and Related Conditions Waves 1 and 2.

PubMed

Cox, Brian J; Clara, Ian P; Worobec, Lydia M; Grant, Bridget F

2012-12-01

Individual personality disorders (PD) are grouped into three clusters in the DSM-IV (A, B, and C). There is very little empirical evidence available concerning the validity of this model in the general population. The current study included all 10 of the DSM-IV PD assessed in Wave 1 and Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Confirmatory factor analysis was used to evaluate three plausible models of the structure of Axis II personality disorders (the current hierarchical DSM-IV three-factor model in which individual PD are believed to load on their assigned clusters, which in turn load onto a single Axis II factor; a general single-factor model; and three independent factors). Each of these models was tested in both the total and also separately for gender. The higher order DSM-IV model demonstrated good fit to the data on a number of goodness-of-fit indices. The results for this model were very similar across genders. A model of PD based on the current DSM-IV hierarchical conceptualization of a higher order classification scheme received strong empirical support through confirmatory factor analysis using a number of goodness-of-fit indices in a nationally representative sample. Other models involving broad, higher order personality domains such as neuroticism in relation to personality disorders have yet to be tested in epidemiologic surveys and represent an important avenue for future research.

A Quantitative Approach for Collocating NEON's Sensor-Based Ecological Measurements and in-situ Field Sampling and Observations

NASA Astrophysics Data System (ADS)

Zulueta, R. C.; Metzger, S.; Ayres, E.; Luo, H.; Meier, C. L.; Barnett, D.; Sanclements, M.; Elmendorf, S.

2013-12-01

The National Ecological Observatory Network (NEON) is a continental-scale research platform currently in development to assess the causes of ecological change and biological responses to change across a projected 30-year timeframe. A suite of standardized sensor-based measurements (i.e., Terrestrial Instrument System (TIS) measurements) and in-situ field sampling and observations (i.e., Terrestrial Observation System (TOS) activities) will be conducted across 20 ecoclimatic domains in the U.S. where NEON is establishing 60 terrestrial research sites. NEON's TIS measurements and TOS activities are designed to observe the temporal and spatial dynamics of key drivers and ecological processes and responses to change within each of the 60 terrestrial research sites. The TIS measurements are non-destructive and designed to provide in-situ, continuous, and areally integrated observations of the surrounding ecosystem and environment, while TOS sampling and observation activities are designed to encompass a hierarchy of measurable biological states and processes including diversity, abundance, phenology, demography, infectious disease prevalence, ecohydrology, and biogeochemistry. To establish valid relationships between these drivers and site-specific responses, two contradicting requirements must be fulfilled: (i) both types of observations shall be representative of the same ecosystem, and (ii) they shall not significantly influence one another. Here we outline the theoretical background and algorithmic process for determining areas of mutual representativeness and exclusion around NEON's TIS measurements and develop a procedure which quantitatively optimizes this trade-off through: (i) quantifying the source area distributions of TIS measurements, (ii) determining the ratio of user-defined impact threshold to effective impact area for different TOS activities, and (iii) determining the range of feasible distances between TIS locations and TOS activities. This approach provides an evidence-based and repeatable method for combining sensor-based measurements and field sampling and observations at predefined levels of disturbance and spatial representativeness. The developed approach represents a general framework which is applicable to other environmental research sites where similar collocation is desired.

Meeting the Need for State-Level Estimates of Health Insurance Coverage: Use of State and Federal Survey Data

PubMed Central

Blewett, Lynn A; Davern, Michael

2006-01-01

Objective Critically review estimates of health insurance coverage available from different sources, including the federal government, state survey initiatives, and foundation-sponsored surveys for use in state policy research. Study Setting and Design We review the surveys in an attempt to flesh out the current weaknesses of survey data for state policy uses. The main data sources assessed in this analysis are federal government surveys (such as the Current Population Survey's Annual Social and Economic Supplement, and the National Health Interview Survey), foundation-supported surveys (National Survey of America's Families, and the Community Tracking Survey), and state-sponsored surveys. Principal Findings Despite information on estimates of health insurance coverage from six federal surveys, states find the data lacking for state policy purposes. We document the need for state representative data on the uninsured and the recent history of state data collection efforts spurred in part by the Health Resources Services Administration State Planning Grant program. We assess the state estimates of uninsurance from the Current Population Survey and make recommendations for a new consolidated federal survey with better state representative data. Conclusions We think there are several options to consider for coordinating a federal and state data collection strategy to inform state and national policy on coverage and access. PMID:16704521

Food waste-to-energy conversion technologies: current status and future directions.

PubMed

Pham, Thi Phuong Thuy; Kaushik, Rajni; Parshetti, Ganesh K; Mahmood, Russell; Balasubramanian, Rajasekhar

2015-04-01

Food waste represents a significantly fraction of municipal solid waste. Proper management and recycling of huge volumes of food waste are required to reduce its environmental burdens and to minimize risks to human health. Food waste is indeed an untapped resource with great potential for energy production. Utilization of food waste for energy conversion currently represents a challenge due to various reasons. These include its inherent heterogeneously variable compositions, high moisture contents and low calorific value, which constitute an impediment for the development of robust, large scale, and efficient industrial processes. Although a considerable amount of research has been carried out on the conversion of food waste to renewable energy, there is a lack of comprehensive and systematic reviews of the published literature. The present review synthesizes the current knowledge available in the use of technologies for food-waste-to-energy conversion involving biological (e.g. anaerobic digestion and fermentation), thermal and thermochemical technologies (e.g. incineration, pyrolysis, gasification and hydrothermal oxidation). The competitive advantages of these technologies as well as the challenges associated with them are discussed. In addition, the future directions for more effective utilization of food waste for renewable energy generation are suggested from an interdisciplinary perspective. Copyright © 2014 Elsevier Ltd. All rights reserved.

Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness.

PubMed

Yunus, Muhammad B

2008-06-01

To discuss the current terminologies used for fibromyalgia syndrome (FMS) and related overlapping conditions, to examine if central sensitivity syndromes (CSS) is the appropriate nosology for these disorders, and to explore the issue of disease versus illness. A literature search was performed through PubMed, Web of Science, and ScienceDirect using a number of keywords, eg, functional somatic syndromes, somatoform disorders, medically unexplained symptoms, organic and nonorganic, and diseases and illness. Relevant articles were then reviewed and representative ones cited. Terminologies currently used for CSS conditions predominantly represent a psychosocial construct and are inappropriate. On the other hand, CSS seems to be the logical nosology based on a biopsychosocial model. Such terms as "medically unexplained symptoms," "somatization," "somatization disorder," and "functional somatic syndromes" in the context of CSS should be abandoned. Given current scientific knowledge, the concept of disease-illness dualism has no rational basis and impedes proper patient-physician communication, resulting in poor patient care. The concept of CSS is likely to promote research, education, and proper patient management. CSS seems to be a useful paradigm and an appropriate terminology for FMS and related conditions. The disease-illness, as well as organic/non-organic dichotomy, should be rejected.

Urbanization and the Carbon Cycle: Synthesis of Ongoing Research

NASA Astrophysics Data System (ADS)

Gurney, K. R.; Duren, R. M.; Hutyra, L.; Ehleringer, J. R.; Patarasuk, R.; Song, Y.; Huang, J.; Davis, K.; Kort, E. A.; Shepson, P. B.; Turnbull, J. C.; Lauvaux, T.; Rao, P.; Eldering, A.; Miller, C. E.; Wofsy, S.; McKain, K.; Mendoza, D. L.; Lin, J. C.; Sweeney, C.; Miles, N. L.; Richardson, S.; Cambaliza, M. O. L.

2015-12-01

Given the explosive growth in urbanization and its dominant role in current and future global greenhouse gas emissions, urban areas have received increasing research attention from the carbon cycle science community. The emerging focus is driven by the increasingly dense atmospheric observing capabilities - ground and space-based - in addition to the rising profile of cities within international climate change policymaking. Dominated by anthropogenic emissions, urban carbon cycle research requires a cross-disciplinary perspective with contributions from disciplines such as engineering, economics, social theory, and atmospheric science. We review the recent results from a sample of the active urban carbon research efforts including the INFLUX experiment (Indianapolis), the Megacity carbon project (Los Angeles), Salt Lake City, and Boston. Each of these efforts represent unique approaches in pursuit of different scientific and policy questions and assist in setting priorities for future research. From top-down atmospheric measurement systems to bottom-up estimation, these research efforts offer a view of the challenges and opportunities in urban carbon cycle research.

The influence of eddy currents on magnetic actuator performance

NASA Technical Reports Server (NTRS)

Zmood, R. B.; Anand, D. K.; Kirk, J. A.

1987-01-01

The present investigation of the effects of eddy currents on EM actuators' transient performance notes that a transfer function representation encompassing a first-order model of the eddy current influence can be useful in control system analysis. The method can be extended to represent the higher-order effects of eddy currents for actuators that cannot be represented by semiinfinite planes.

Regular-Soda Intake Independent of Weight Status Is Associated with Asthma among US High School Students

PubMed Central

Park, Sohyun; Blanck, Heidi M.; Sherry, Bettylou; Jones, Sherry Everett; Pan, Liping

2015-01-01

Limited research shows an inconclusive association between soda intake and asthma, potentially attributable to certain preservatives in sodas. This cross-sectional study examined the association between regular (nondiet)-soda intake and current asthma among a nationally representative sample of high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 15,960 students (grades 9 through 12) with data for both regular-soda intake and current asthma status. The outcome measure was current asthma (ie, told by doctor/nurse that they had asthma and still have asthma). The main exposure variable was regular-soda intake (ie, drank a can/bottle/glass of soda during the 7 days before the survey). Multivariable logistic regression was used to estimate the adjusted odds ratios for regular-soda intake with current asthma after controlling for age, sex, race/ethnicity, weight status, and current cigarette use. Overall, 10.8% of students had current asthma. In addition, 9.7% of students who did not drink regular soda had current asthma, and 14.7% of students who drank regular soda three or more times per day had current asthma. Compared with those who did not drink regular soda, odds of having current asthma were higher among students who drank regular soda two times per day (adjusted odds ratio = 1.28; 95% CI 1.02 to 1.62) and three or more times per day (adjusted odds ratio = 1.64; 95% CI 1.25 to 2.16). The association between high regular-soda intake and current asthma suggests efforts to reduce regular-soda intake among youth might have benefits beyond improving diet quality. However, this association needs additional research, such as a longitudinal examination. PMID:23260727

Regular-soda intake independent of weight status is associated with asthma among US high school students.

PubMed

Park, Sohyun; Blanck, Heidi M; Sherry, Bettylou; Jones, Sherry Everett; Pan, Liping

2013-01-01

Limited research shows an inconclusive association between soda intake and asthma, potentially attributable to certain preservatives in sodas. This cross-sectional study examined the association between regular (nondiet)-soda intake and current asthma among a nationally representative sample of high school students. Analysis was based on the 2009 national Youth Risk Behavior Survey and included 15,960 students (grades 9 through 12) with data for both regular-soda intake and current asthma status. The outcome measure was current asthma (ie, told by doctor/nurse that they had asthma and still have asthma). The main exposure variable was regular-soda intake (ie, drank a can/bottle/glass of soda during the 7 days before the survey). Multivariable logistic regression was used to estimate the adjusted odds ratios for regular-soda intake with current asthma after controlling for age, sex, race/ethnicity, weight status, and current cigarette use. Overall, 10.8% of students had current asthma. In addition, 9.7% of students who did not drink regular soda had current asthma, and 14.7% of students who drank regular soda three or more times per day had current asthma. Compared with those who did not drink regular soda, odds of having current asthma were higher among students who drank regular soda two times per day (adjusted odds ratio=1.28; 95% CI 1.02 to 1.62) and three or more times per day (adjusted odds ratio=1.64; 95% CI 1.25 to 2.16). The association between high regular-soda intake and current asthma suggests efforts to reduce regular-soda intake among youth might have benefits beyond improving diet quality. However, this association needs additional research, such as a longitudinal examination. Published by Elsevier Inc.

Evaluation of Visual Analytics Environments: The Road to the Visual Analytics Science and Technology Challenge Evaluation Methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholtz, Jean; Plaisant, Catherine; Whiting, Mark A.

The evaluation of visual analytics environments was a topic in Illuminating the Path [Thomas 2005] as a critical aspect of moving research into practice. For a thorough understanding of the utility of the systems available, evaluation not only involves assessing the visualizations, interactions or data processing algorithms themselves, but also the complex processes that a tool is meant to support (such as exploratory data analysis and reasoning, communication through visualization, or collaborative data analysis [Lam 2012; Carpendale 2007]). Researchers and practitioners in the field have long identified many of the challenges faced when planning, conducting, and executing an evaluation ofmore » a visualization tool or system [Plaisant 2004]. Evaluation is needed to verify that algorithms and software systems work correctly and that they represent improvements over the current infrastructure. Additionally to effectively transfer new software into a working environment, it is necessary to ensure that the software has utility for the end-users and that the software can be incorporated into the end-user’s infrastructure and work practices. Evaluation test beds require datasets, tasks, metrics and evaluation methodologies. As noted in [Thomas 2005] it is difficult and expensive for any one researcher to setup an evaluation test bed so in many cases evaluation is setup for communities of researchers or for various research projects or programs. Examples of successful community evaluations can be found [Chinchor 1993; Voorhees 2007; FRGC 2012]. As visual analytics environments are intended to facilitate the work of human analysts, one aspect of evaluation needs to focus on the utility of the software to the end-user. This requires representative users, representative tasks, and metrics that measure the utility to the end-user. This is even more difficult as now one aspect of the test methodology is access to representative end-users to participate in the evaluation. In many cases the sensitive nature of data and tasks and difficult access to busy analysts puts even more of a burden on researchers to complete this type of evaluation. User-centered design goes beyond evaluation and starts with the user [Beyer 1997, Shneiderman 2009]. Having some knowledge of the type of data, tasks, and work practices helps researchers and developers know the correct paths to pursue in their work. When access to the end-users is problematic at best and impossible at worst, user-centered design becomes difficult. Researchers are unlikely to go to work on the type of problems faced by inaccessible users. Commercial vendors have difficulties evaluating and improving their products when they cannot observe real users working with their products. In well-established fields such as web site design or office software design, user-interface guidelines have been developed based on the results of empirical studies or the experience of experts. Guidelines can speed up the design process and replace some of the need for observation of actual users [heuristics review references]. In 2006 when the visual analytics community was initially getting organized, no such guidelines existed. Therefore, we were faced with the problem of developing an evaluation framework for the field of visual analytics that would provide representative situations and datasets, representative tasks and utility metrics, and finally a test methodology which would include a surrogate for representative users, increase interest in conducting research in the field, and provide sufficient feedback to the researchers so that they could improve their systems.« less

Effects of urban debris material on the extraction chromatographic separation of strontium: Part II: cement and concrete

DOE PAGES

McLain, Derek R.; Liu, Christine; Sudowe, Ralf

2017-11-02

The majority of radiochemical separation schemes available have been developed for environmental samples that are not necessarily representative of those found in an urban environment. However, it is much more likely that an incident involving a radiation dispersal device (RDD) would occur in an urban or metropolitan area. It is unclear if the currently available separation schemes would be effective in such an event. It is therefore important to determine if the current schemes would be adequate, or to find efficient and accurate ways to separate radiological material from urban debris. One important radiological material that could be used inmore » an RDD is 90Sr. Part I of this work investigated the effects steel had on strontium separations, while this work investigates cement and concrete. This research demonstrates that the individual elements present in a cement and concrete sample matrix can give rise to significant interferences with extraction chromatographic separations. In conclusion, solutions of the constituents mixed in representative ratios; however, show fewer problems« less

Effects of urban debris material on the extraction chromatographic separation of strontium: Part II: cement and concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLain, Derek R.; Liu, Christine; Sudowe, Ralf

The majority of radiochemical separation schemes available have been developed for environmental samples that are not necessarily representative of those found in an urban environment. However, it is much more likely that an incident involving a radiation dispersal device (RDD) would occur in an urban or metropolitan area. It is unclear if the currently available separation schemes would be effective in such an event. It is therefore important to determine if the current schemes would be adequate, or to find efficient and accurate ways to separate radiological material from urban debris. One important radiological material that could be used inmore » an RDD is 90Sr. Part I of this work investigated the effects steel had on strontium separations, while this work investigates cement and concrete. This research demonstrates that the individual elements present in a cement and concrete sample matrix can give rise to significant interferences with extraction chromatographic separations. In conclusion, solutions of the constituents mixed in representative ratios; however, show fewer problems« less

Lung texture classification using bag of visual words

NASA Astrophysics Data System (ADS)

Asherov, Marina; Diamant, Idit; Greenspan, Hayit

2014-03-01

Interstitial lung diseases (ILD) refer to a group of more than 150 parenchymal lung disorders. High-Resolution Computed Tomography (HRCT) is the most essential imaging modality of ILD diagnosis. Nonetheless, classification of various lung tissue patterns caused by ILD is still regarded as a challenging task. The current study focuses on the classification of five most common categories of lung tissues of ILD in HRCT images: normal, emphysema, ground glass, fibrosis and micronodules. The objective of the research is to classify an expert-given annotated region of interest (AROI) using a bag of visual words (BoVW) framework. The images are divided into small patches and a collection of representative patches are defined as visual words. This procedure, termed dictionary construction, is performed for each individual lung texture category. The assumption is that different lung textures are represented by a different visual word distribution. The classification is performed using an SVM classifier with histogram intersection kernel. In the experiments, we use a dataset of 1018 AROIs from 95 patients. Classification using a leave-one-patient-out cross validation (LOPO CV) is used. Current classification accuracy obtained is close to 80%.

The current status of animal use and alternatives in Korean veterinary medical schools.

PubMed

Lee, Gwi Hyang; Choe, Byung In; Kim, Jin Suk; Hart, Lynette A; Han, Jin Soo

2010-06-01

Two new Korean laws regulating animal welfare and the humane use of animals in science came into effect in 2008 and 2009. Both these laws impose ethical committee review prior to the performance of animal experiments in research, testing and education. This study briefly summarises the new Korean laws, and investigates the current status regarding the numbers of animals used, the alternatives to animals which are used, the curricula relating to the humane use of animals, and ethical review practices in Korean veterinary education. Approximately 4,845 animals, representing 20 different species, were used in veterinary medical education in Korea in 2007. Korea has begun to introduce formal courses on animal welfare for the humane treatment of animals used in experiments, and an ethical protocol review system prior to animal use in education. Korea is moving toward better animal welfare, by incorporating practices consistent with international standards. The information presented represents the first such data gathered in Korea, which should prove useful for monitoring the implementation of replacement, reduction, and refinement measures in animal use for education purposes.

Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies

PubMed Central

Hettmer, Simone; Li, Zhizhong; Billin, Andrew N.; Barr, Frederic G.; Cornelison, D.D.W.; Ehrlich, Alan R.; Guttridge, Denis C.; Hayes-Jordan, Andrea; Helman, Lee J.; Houghton, Peter J.; Khan, Javed; Langenau, David M.; Linardic, Corinne M.; Pal, Ranadip; Partridge, Terence A.; Pavlath, Grace K.; Rota, Rossella; Schäfer, Beat W.; Shipley, Janet; Stillman, Bruce; Wexler, Leonard H.; Wagers, Amy J.; Keller, Charles

2014-01-01

Rhabdomyosarcoma (RMS) represents a rare, heterogeneous group of mesodermal malignancies with skeletal muscle differentiation. One major subgroup of RMS tumors (so-called “fusion-positive” tumors) carries exclusive chromosomal translocations that join the DNA-binding domain of the PAX3 or PAX7 gene to the transactivation domain of the FOXO1 (previously known as FKHR) gene. Fusion-negative RMS represents a heterogeneous spectrum of tumors with frequent RAS pathway activation. Overtly metastatic disease at diagnosis is more frequently found in individuals with fusion-positive than in those with fusion-negative tumors. RMS is the most common pediatric soft-tissue sarcoma, and approximately 60% of all children and adolescents diagnosed with RMS are cured by currently available multimodal therapies. However, a curative outcome is achieved in <30% of high-risk individuals with RMS, including all those diagnosed as adults, those diagnosed with fusion-positive tumors during childhood (including metastatic and nonmetastatic tumors), and those diagnosed with metastatic disease during childhood (including fusion-positive and fusion-negative tumors). This white paper outlines current challenges in RMS research and their implications for developing more effective therapies. Urgent clinical problems include local control, systemic disease, need for improved risk stratification, and characterization of differences in disease course in children and adults. Biological challenges include definition of the cellular functions of PAX-FOXO1 fusion proteins, clarification of disease heterogeneity, elucidation of the cellular origins of RMS, delineation of the tumor microenvironment, and identification of means for rational selection and testing of new combination therapies. To streamline future therapeutic developments, it will be critical to improve access to fresh tumor tissue for research purposes, consider alternative trial designs to optimize early clinical testing of candidate drugs, coalesce advocacy efforts to garner public and industry support, and facilitate collaborative efforts between academia and industry. PMID:25368019

[Community interventions among tobacco control strategies: coping with their definition and evaluation].

PubMed

D'Elia, Paolo; Coppo, Alessandro; Di Stefano, Francesca; Charrier, Lorena; Piccinelli, Cristiano; Molinar, Roberta; Senore, Carlo; Giordano, Livia; Segnan, Nereo

2008-01-01

Community interventions represent a key component of the current anti-smoking strategies. We propose a conceptual framework for classifying these interventions, based on the concept of community utilised in different studies. We identified 5 different focuses: geographical areas (i.e. city, county, region); targets (sub-group of a population); settings (school, workplace); culture and individual attitudes; multilevel networks. These two latter views refer to functional rather than to structural aspects of a community and they represent the most promising approaches to design intervention strategies. Communities are represented as a group of organizations, systems and social networks investigating individual, environmental and cultural factors that can strongly influence behavioural changes. The great heterogeneity in what the authors mean as community interventions has in our opinion affected the evaluation of their impact. To facilitate their evaluation and to contribute to the detection of determinants, as well as of barriers, it is necessary to compare community interventions sharing similar theoretical approaches and focuses. Also, studies aimed at assessing the steps of the implementation process of community programmes may allow to identify those components related to specific levels of intervention, thus enabling the generalisation of results. To reach this goal it may be helpful to combine study designs allowing for both quantitative and qualitative assessments, such as action research and participatory evaluation research.

The Severe 5%: A Latent Class Analysis of the Externalizing Behavior Spectrum in the United States

PubMed Central

Vaughn, Michael G.; DeLisi, Matt; Gunterbh, Tracy; Fu, Qiang; Beaver, Kevin M.; Perron, Brian E.; Howard, Matthew O.

2012-01-01

Objective Criminological research consistently demonstrates that approximately 5% of study populations are comprised of pathological offenders who account for a preponderance of antisocial behavior and violent crime. Unfortunately, there have been no nationally representative epidemiological studies characterizing the severe 5% group. Materials and Methods Data from the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative sample of 43,093 non-institutionalized U.S. residents aged 18 years and older were analyzed using latent class analysis to assess sociodemographic, psychiatric, and behavioral characteristics. Results Four-classes of respondents were identified vis-à-vis lifetime externalizing behaviors. A normative class (66.1% of respondents) demonstrated little involvement in antisocial conduct. A low substance use/high antisocial behavior class (20.7% of respondents) and high substance use/moderate antisocial behavior (8.0% of respondents) class evinced diverse externalizing and psychiatric symptoms. Finally, a severe class (5.3% of respondents) was characterized by pathological involvement in more varied and intensive forms of antisocial and externalizing behaviors and extensive psychiatric disturbance. Conclusions The current study is the first nationally representative epidemiological study of criminal careers/externalizing behavior spectrum in the United States and validates the existence of the 5% pathological group demonstrated by prior research. PMID:22942480

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

PubMed Central

Peck, Michael W.; Smith, Theresa J.; Anniballi, Fabrizio; Austin, John W.; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa W.; Derman, Yagmur; Dorner, Brigitte G.; Fisher, Audrey; Hill, Karen K.; Kalb, Suzanne R.; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Lúquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel R.; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal Ram; Stringer, Sandra C.

2017-01-01

Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future. PMID:28106761

Linking Antisocial Behavior, Substance Use, and Personality: An Integrative Quantitative Model of the Adult Externalizing Spectrum

PubMed Central

Krueger, Robert F.; Markon, Kristian E.; Patrick, Christopher J.; Benning, Stephen D.; Kramer, Mark D.

2008-01-01

Antisocial behavior, substance use, and impulsive and aggressive personality traits often co-occur, forming a coherent spectrum of personality and psychopathology. In the current research, the authors developed a novel quantitative model of this spectrum. Over 3 waves of iterative data collection, 1,787 adult participants selected to represent a range across the externalizing spectrum provided extensive data about specific externalizing behaviors. Statistical methods such as item response theory and semiparametric factor analysis were used to model these data. The model and assessment instrument that emerged from the research shows how externalizing phenomena are organized hierarchically and cover a wide range of individual differences. The authors discuss the utility of this model for framing research on the correlates and the etiology of externalizing phenomena. PMID:18020714

Professional failure to thrive: a threat to high-quality care?

PubMed

Stamler, Lynnette Leeseberg; Gabriel, Aaron M

2010-03-01

The term professional failure to thrive arose from descriptions of non-organic failure to thrive in infants and observations of nurses' behaviours. First coined by Stamler in 1997, subsequent unrelated research results have supported the theoretical construct. In an era when patient safety and high-quality care have never been more important, and nursing retention has reached heretofore unknown levels of global concern, critical examination of factors that may alleviate professional issues and support high-quality healthcare is especially useful. In this paper, we suggest theoretical causes for professional failure to thrive (PFTT) and associated behaviours exhibited by nurses, and draw links to current research to support the theory. Given the theoretical support, PFTT represents an additional avenue that should be considered and explored through research studies.

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

PubMed

Peck, Michael W; Smith, Theresa J; Anniballi, Fabrizio; Austin, John W; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa W; Derman, Yagmur; Dorner, Brigitte G; Fisher, Audrey; Hill, Karen K; Kalb, Suzanne R; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Lúquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel R; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal Ram; Stringer, Sandra C

2017-01-18

Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.

Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy

PubMed Central

Wheatley, Lisa M; Plaut, Marshall; Schwaninger, Julie M; Banerji, Aleena; Castells, Mariana; Finkelman, Fred D.; Gleich, Gerald J.; Guttman-Yassky, Emma; Mallal, Simon A.K.; Naisbitt, Dean J.; Ostrov, David A.; Phillips, Elizabeth J.; Pichler, Werner J.; Platts-Mills, Thomas A. E.; Roujeau, Jean-Claude; Schwartz, Lawrence B.; Trepanier, Lauren A.

2015-01-01

Allergic reactions to drugs are a serious public health concern. In 2013, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several NIH Institutes and the U.S. Food and Drug Administration (FDA). The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein. PMID:26254053

Clinical trials needed to evaluate compression therapy in breast cancer related lymphedema (BCRL). Proposals from an expert group.

PubMed

Partsch, H; Stout, N; Forner-Cordero, I; Flour, M; Moffatt, C; Szuba, A; Milic, D; Szolnoky, G; Brorson, H; Abel, M; Schuren, J; Schingale, F; Vignes, S; Piller, N; Döller, W

2010-10-01

A mainstay of lymphedema management involves the use of compression therapy. Compression therapy application is variable at different levels of disease severity. Evidence is scant to direct clinicians in best practice regarding compression therapy use. Further, compression clinical trials are fragmented and poorly extrapolable to the greater population. An ideal construct for conducting clinical trials in regards to compression therapy will promote parallel global initiatives based on a standard research agenda. The purpose of this article is to review current evidence in practice regarding compression therapy for BCRL management and based on this evidence, offer an expert consensus recommendation for a research agenda and prescriptive trials. Recommendations herein focus solely on compression interventions. This document represents the proceedings of a session organized by the International Compression Club (ICC) in June 2009 in Ponzano (Veneto, Italy). The purpose of the meeting was to enable a group of experts to discuss the existing evidence for compression treatment in breast cancer related lymphedema (BCRL) concentrating on areas where randomized controlled trials (RCTs) are lacking. The current body of research suggests efficacy of compression interventions in the treatment and management of lymphedema. However, studies to date have failed to adequately address various forms of compression therapy and their optimal application in BCRL. We offer recommendations for standardized compression research trials for prophylaxis of arm lymphedema and for the management of chronic BCRL. Suggestions are also made regarding; inclusion and exclusion criteria, measurement methodology and additional variables of interest for researchers to capture. This document should inform future research trials in compression therapy and serve as a guide to clinical researchers, industry researchers and lymphologists regarding the strengths, weaknesses and shortcomings of the current literature. By providing this construct for research trials, the authors aim to support evidence-based therapy interventions, promote a cohesive, standardized and informative body of literature to enhance clinical outcomes, improve the quality of future research trials, inform industry innovation and guide policy related to BCRL.

The SeaFlux Turbulent Flux Dataset Version 1.0 Documentation

NASA Technical Reports Server (NTRS)

Clayson, Carol Anne; Roberts, J. Brent; Bogdanoff, Alec S.

2012-01-01

Under the auspices of the World Climate Research Programme (WCRP) Global Energy and Water cycle EXperiment (GEWEX) Data and Assessment Panel (GDAP), the SeaFlux Project was created to investigate producing a high-resolution satellite-based dataset of surface turbulent fluxes over the global oceans. The most current release of the SeaFlux product is Version 1.0; this represents the initial release of turbulent surface heat fluxes, associated near-surface variables including a diurnally varying sea surface temperature.

A review of the physics and response models for burnout of semiconductor devices

NASA Astrophysics Data System (ADS)

Orvis, W. J.; Khanaka, G. H.; Yee, J. H.

1984-12-01

Physical mechanisms that cause semiconductor devices to fail from electrical overstress--particularly, EMP-induced electrical stress--are described in light of the current literature and the authors' own research. A major concern is the cause and effects of second breakdown phenomena in p-n junction devices. Models of failure thresholds are evaluated for their inherent errors and for their ability to represent the relevant physics. Finally, the response models that relate electromagnetic stress parameters to appropriate failure-threshold parameters are discussed.

Long-term follow up of astronaut health indices

NASA Technical Reports Server (NTRS)

Nicogossian, A. E.; Moseley, E.; Leach-Huntoon, C.; Pool, S.

1988-01-01

Ground-based research and reevaluation of flight data is currently in progress in order to develop suitable and operationally acceptable medical standards for extended-duration manned space missions. The large amount of data obtained thus far constitutes a unique data base representative of the astronaut population. In this paper, preliminary 10-year findings of prospective studies established in 1977 are described, and results obtained from retrospective studies conducted on data accumulated prior to the 1977 establishment of medical selection standards are summarized.

Application of Remote Sensing to the Chesapeake Bay Region. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Chen, W. T.; Freas, G. W., Jr.; Hickman, G. D.; Pemberton, D. A.; Wilkerson, T. D.; Adler, I.; Laurie, V. J.

1978-01-01

The proceedings are presented of a conference, jointly sponsored by the National Aeronautics and Space Administration, the U.S. Environmental Protection Agency, and the University of Maryland. The purpose of the Conference was to assemble representatives of federal and state government agencies engaged in research on the condition and evolution of the Chesapeake Bay to compose a status report, to present current activities and future plans, and to recommend a long-range future course of policies and programs.

Foil focusing of relativistic electron beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ekdahl, Jr., Carl August

2017-10-26

When an intense relativistic electron beams (IREB) passes through a grounded metal foil, the transverse electric field due to the beam space charge is locally shorted out, and the beam is focused by the magnetic field of its current. The effect can be treated as focusing by a thin lens with first order aberration. Expressions for the focal length and aberration coefficient of the equivalent thin lens are developed in this note. These are then applied to practical examples representative of IREB research at Los Alamos National Laboratory.

A study of the age attribute in a query tool for a clinical data warehouse.

PubMed

Scheufele, Elisabeth L; Scheufele, Elisabeth Lee; Dubey, Anil; Dubey, Anil Kumar; Murphy, Shawn N

2008-11-06

The RPDR, a clinical data warehouse with a user-friendly Querytool, allows researchers to perform studies on patient data. Currently, the RPDR represents age as the patient's age at the present time, which is problematic in situations where age at the time of the event is more appropriate. We will modify the Querytool to consider this by assessing the perception of age via survey, testing backend query solutions, and developing modifications based on these results.

Biorefineries--multi product processes.

PubMed

Kamm, B; Kamm, M

2007-01-01

The development of biorefineries represents the key for access to an integrated production of food, feed, chemicals, materials, goods, and fuels of the future [1]. Biorefineries combine the necessary technologies of the biogenic raw materials with those of intermediates and final products. The main focus is directed at the precursors carbohydrates, lignin, oils, and proteins and the combination between biotechnological and chemical conversion of substances. Currently the lignocellulosic feedstock biorefinery, green biorefinery, whole corn biorefinery, and the so-called two-platform concept are favored in research, development, and industrial implementation.

Evaluation of outdoor-to-indoor response to minimized sonic booms

NASA Technical Reports Server (NTRS)

Brown, David; Sutherland, Louis C.

1992-01-01

Various studies were conducted by NASA and others on the practical limitations of sonic boom signature shaping/minimization for the High-Speed Civil Transport (HSCT) and on the effects of these shaped boom signatures on perceived loudness. This current effort is a further part of this research with emphasis on examining shaped boom signatures which are representative of the most recent investigations of practical limitations on sonic boom minimization, and on examining and comparing the expected response to these signatures when experienced indoors and outdoors.

Aviation turbine fuels: An assessment of alternatives

NASA Technical Reports Server (NTRS)

1982-01-01

The general outlook for aviation turbine fuels, the effect that broadening permissible aviation turbine fuel properties could have on the overall availability of such fuels, the fuel properties most likely to be affected by use of lower grade petroleum crudes, and the research and technology required to ensure that aviation turbine fuels and engines can function satisfactorily with fuels having a range of fuel properties differing from those of current specification fuel are assessed. Views of industry representatives on alternative aviation turbine fuels are presented.

Research on the optimization of vehicle distribution routes in logistics enterprises

NASA Astrophysics Data System (ADS)

Fan, Zhigou; Ma, Mengkun

2018-01-01

With the rapid development of modern logistics, the vehicle routing problem has become one of the urgent problems in the logistics industry. The rationality of distribution route planning directly affects the efficiency and quality of logistics distribution. This paper first introduces the definition of logistics distribution and the three methods of optimizing the distribution routes, and then analyzes the current vehicle distribution route by using a representative example, finally puts forward the optimization schemes of logistics distribution route.

Agenda: EDRN FDA Education Workshop — EDRN Public Portal

Cancer.gov

The purpose of this workshop was to open dialogue between FDA staff that provide oversight for review of in vitro diagnostic applications and EDRN scientists currently performing clinical validation studies on cancer biomarkers. Issues related to FDA review of diagnostic tests were presented by FDA personnel. Representatives from EDRN provided details on supporting data of their validation studies and the resources developed within EDRN to facilitate such research for FDA compliance. The agenda provided here provides links to the presentations by each speaker.

Component 1: Current and Future Methods for Representing and Interacting with Qualitative Geographic Information

DTIC Science & Technology

2011-10-26

the user in a graphical fashion. Despite the fact that tag clouds are now ubiquitous (Cidell 2010 , Lee et al . 2010 , Viégas, Wattenberg and Feinberg...this work (e.g. Compus) focused on exploration of document structure explicitly (Figure 3), other research (Krstajic et al . 2010 ) has focused on...geographic visualization tool called HealthGeoJunction focused on foraging PubMed articles about avian influenza (MacEachren et al . 2010 ). 5 | P a g e

World Workshop on Oral Medicine VI: Utilization of Oral Medicine-specific software for support of clinical care, research, and education: current status and strategy for broader implementation.

PubMed

Brailo, Vlaho; Firriolo, Francis John; Tanaka, Takako Imai; Varoni, Elena; Sykes, Rosemary; McCullough, Michael; Hua, Hong; Sklavounou, Alexandra; Jensen, Siri Beier; Lockhart, Peter B; Mattsson, Ulf; Jontell, Mats

2015-08-01

To assess the current scope and status of Oral Medicine-specific software (OMSS) utilized to support clinical care, research, and education in Oral Medicine and to propose a strategy for broader implementation of OMSS within the global Oral Medicine community. An invitation letter explaining the objectives was sent to the global Oral Medicine community. Respondents were interviewed to obtain information about different aspects of OMSS functionality. Ten OMSS tools were identified. Four were being used for clinical care, one was being used for research, two were being used for education, and three were multipurpose. Clinical software was being utilized as databases developed to integrate of different type of clinical information. Research software was designed to facilitate multicenter research. Educational software represented interactive, case-orientated technology designed for clinical training in Oral Medicine. Easy access to patient data was the most commonly reported advantage. Difficulty of use and poor integration with other software was the most commonly reported disadvantage. The OMSS presented in this paper demonstrate how information technology (IT) can have an impact on the quality of patient care, research, and education in the field of Oral Medicine. A strategy for broader implementation of OMSS is proposed. Copyright © 2015 Elsevier Inc. All rights reserved.