Fisher, Neyman-Pearson or NHST? A tutorial for teaching data testing.

PubMed

Perezgonzalez, Jose D

2015-01-01

Despite frequent calls for the overhaul of null hypothesis significance testing (NHST), this controversial procedure remains ubiquitous in behavioral, social and biomedical teaching and research. Little change seems possible once the procedure becomes well ingrained in the minds and current practice of researchers; thus, the optimal opportunity for such change is at the time the procedure is taught, be this at undergraduate or at postgraduate levels. This paper presents a tutorial for the teaching of data testing procedures, often referred to as hypothesis testing theories. The first procedure introduced is Fisher's approach to data testing-tests of significance; the second is Neyman-Pearson's approach-tests of acceptance; the final procedure is the incongruent combination of the previous two theories into the current approach-NSHT. For those researchers sticking with the latter, two compromise solutions on how to improve NHST conclude the tutorial.

Effects of aggregate angularity on mix design characteristics and pavement performance.

DOT National Transportation Integrated Search

2009-12-01

This research targeted two primary purposes: to estimate current aggregate angularity test methods and to evaluate current : aggregate angularity requirements in the Nebraska asphalt mixture/pavement specification. To meet the first research : object...

Lightning Tests on the WC-130 Research Aircraft.

DTIC Science & Technology

1982-12-01

in the WC-136 tests at various times.) E- Feild Fiber Optic Test Article Sensor Transmitter (Typ)WiePr Indtuced Voltag Sensor"" *Fiber I"=Current optic...well-characterized. 5.1 Skin Current Measurements Skin current vectors were measured at five fuselage locations on the left side of the WC-130 at a...MGL-S7) which were mounted so that they sampled two orthogonal components of the skin current vector . The measured responses were then inte- grated

Current efforts on developing an HWIL synthetic environment for LADAR sensor testing at AMRDEC

NASA Astrophysics Data System (ADS)

Kim, Hajin J.; Cornell, Michael C.; Naumann, Charles B.

2005-05-01

Efforts in developing a synthetic environment for testing LADAR sensors in a hardware-in-the-loop simulation are continuing at the Aviation and Missile Research, Engineering, and Development Center (AMRDEC) of the U.S. Army Research, Engineering and Development Command (RDECOM). Current activities have concentrated on developing the optical projection hardware portion of the synthetic environment. These activities range from system level design down to component level testing. Of particular interest have been schemes for generating the optical signals representing the individual pixels of the projection. Several approaches have been investigated and tested with emphasis on operating wavelength, intensity dynamic range and uniformity, and flexibility in pixel waveform generation. This paper will discuss some of the results from these current efforts at RDECOM's Advanced Simulation Center (ASC).

Effects of Total SAT® Test Time on Performance and Fatigue. Research Notes. RN-37

ERIC Educational Resources Information Center

Ackerman, Phillip L.; Kanfer, Ruth; Wolman, Stacey D.

2005-01-01

The current study was designed to examine performance effects and fatigue effects associated with different total SAT testing times. In addition, the researchers examined personality, motivation, and other determinants of individual differences in examinee fatigue before, during, and after testing.

The NASA integrated test facility and its impact on flight research

NASA Technical Reports Server (NTRS)

Mackall, D. A.; Pickett, M. D.; Schilling, L. J.; Wagner, C. A.

1988-01-01

The Integrated Test Facility (ITF), being built at NASA Ames-Dryden Flight Research Facility, will provide new test capabilities for emerging research aircraft. An overview of the ITF and the challenges being addressed by this unique facility are outlined. The current ITF capabilities, being developed with the X-29 Forward Swept Wing Program, are discussed along with future ITF activities.

Instrumentation and telemetry systems for free-flight drop model testing

NASA Technical Reports Server (NTRS)

Hyde, Charles R.; Massie, Jeffrey J.

1993-01-01

This paper presents instrumentation and telemetry system techniques used in free-flight research drop model testing at the NASA Langley Research Center. The free-flight drop model test technique is used to conduct flight dynamics research of high performance aircraft using dynamically scaled models. The free-flight drop model flight testing supplements research using computer analysis and wind tunnel testing. The drop models are scaled to approximately 20 percent of the size of the actual aircraft. This paper presents an introduction to the Free-Flight Drop Model Program which is followed by a description of the current instrumentation and telemetry systems used at the NASA Langley Research Center, Plum Tree Test Site. The paper describes three telemetry downlinks used to acquire the data, video, and radar tracking information from the model. Also described are two telemetry uplinks, one used to fly the model employing a ground-based flight control computer and a second to activate commands for visual tracking and parachute recovery of the model. The paper concludes with a discussion of free-flight drop model instrumentation and telemetry system development currently in progress for future drop model projects at the NASA Langley Research Center.

Adolescent Attitudes toward Random Drug Testing in Schools

ERIC Educational Resources Information Center

Russell, Brenda L.; Jennings, Brian; Classey, Sherry

2005-01-01

The current research examined students' perceptions of random drug testing for students participating in after-school activities. Results found students were more likely to endorse drug testing at their school if they are already engaged in after-school activities and not currently using drugs and/or alcohol. While middle and high school students'…

Test facilities of the structural dynamics branch of NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Montague, Gerald T.; Kielb, Robert E.

1988-01-01

The NASA Lewis Research Center Structural Dynamics Branch conducts experimental and analytical research related to the structural dynamics of aerospace propulsion and power systems. The experimental testing facilities of the branch are examined. Presently there are 10 research rigs and 4 laboratories within the branch. These facilities are described along with current and past research work.

77 FR 51528 - Notice of Public Hearings for the Draft Environmental Impact Statement for Outdoor Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

... Impact Statement for Outdoor Research, Development, Test and Evaluation Activities, Naval Surface Warfare..., development, test and evaluation (RDT&E) activities within the Potomac River Test Range (PRTR) complex... current, baseline RDT&E mission requirements for activities that have the potential to affect human health...

Does Listening to Mozart Affect Listening Ability?

ERIC Educational Resources Information Center

Bowman, Becki J.; Punyanunt-Carter, Narissra; Cheah, Tsui Yi; Watson, W. Joe; Rubin, Rebecca B.

2007-01-01

Considerable research has been conducted testing Rauscher, Shaw, and Ky's (1993) Mozart Effect (ME). This study attempts to replicate, in part, research that tested the ME on listening comprehension abilities. Also included in this study is an examination of control group issues in current day research. We hypothesized that students who listen to…

Teaching-Learning Conceptions and Academic Achievement: The Mediating Role of Test Anxiety

ERIC Educational Resources Information Center

Bas, Gökhan

2016-01-01

The current research aimed at examining the mediating role of test anxiety in the relationship between teaching-learning conceptions and academic achievement. The correlation investigation model was adopted in this research. The participants of the research were volunteering teachers (n = 108) and students (n = 526) from five different high…

Current progress in patient-specific modeling

PubMed Central

2010-01-01

We present a survey of recent advancements in the emerging field of patient-specific modeling (PSM). Researchers in this field are currently simulating a wide variety of tissue and organ dynamics to address challenges in various clinical domains. The majority of this research employs three-dimensional, image-based modeling techniques. Recent PSM publications mostly represent feasibility or preliminary validation studies on modeling technologies, and these systems will require further clinical validation and usability testing before they can become a standard of care. We anticipate that with further testing and research, PSM-derived technologies will eventually become valuable, versatile clinical tools. PMID:19955236

Modification of NASA Langley 8 foot high temperature tunnel to provide a unique national research facility for hypersonic air-breathing propulsion systems

NASA Technical Reports Server (NTRS)

Kelly, H. N.; Wieting, A. R.

1984-01-01

A planned modification of the NASA Langley 8-Foot High Temperature Tunnel to make it a unique national research facility for hypersonic air-breathing propulsion systems is described, and some of the ongoing supporting research for that modification is discussed. The modification involves: (1) the addition of an oxygen-enrichment system which will allow the methane-air combustion-heated test stream to simulate air for propulsion testing; and (2) supplemental nozzles to expand the test simulation capability from the current nominal Mach number to 7.0 include Mach numbers 3.0, 4.5, and 5.0. Detailed design of the modifications is currently underway and the modified facility is scheduled to be available for tests of large scale propulsion systems by mid 1988.

Evaluation of the damages caused by lightning current flowing through bearings

NASA Technical Reports Server (NTRS)

Celi, O.; Pigini, A.; Garbagnati, E.

1991-01-01

A laboratory for lightning current tests was set up allowing the generation of the lightning currents foreseen by the Standards. Lightning tests are carried out on different objects, aircraft materials and components, evaluating the direct and indirect effects of lightning. Recently a research was carried out to evaluate the effects of the lightning current flow through bearings with special reference to wind power generator applications. For this purpose, lightning currents of different amplitude were applied to bearings in different test conditions and the damages caused by the lightning current flow were analyzed. The influence of the load acting on the bearing, the presence of lubricant and the bearing rotation were studied.

State of play in direct-to-consumer genetic testing for lifestyle-related diseases: market, marketing content, user experiences and regulation.

PubMed

Saukko, Paula

2013-02-01

Direct-to-consumer (DTC) genetic tests have aroused controversy. Critics have argued many of the tests are not backed by scientific evidence, misguide their customers and should be regulated more stringently. Proponents suggest that finding out genetic susceptibilities for diseases could encourage healthier behaviours and makes the results of genetics research available to the public. This paper reviews the state of play in DTC genetic testing, focusing on tests identifying susceptibilities for lifestyle-related diseases. It will start with mapping the market for the tests. The paper will review (1) research on the content of the online marketing of DTC tests, (2) studies on the effects of DTC genetic tests on customers and (3) academic and policy proposals on how to regulate the tests. Current studies suggest that the marketing of DTC genetic tests often exaggerates their predictive powers, which could misguide consumers. However, research indicates that the tests do not seem to have major negative effects (worry and confusion) but neither do they engender positive effects (lifestyle change) on current users. Research on regulation of the tests has most commonly suggested regulating the marketing claims of the companies. In conclusion, the risks and benefits of DTC genetic tests are less significant than what has been predicted by critics and proponents, which will be argued reflects broader historical trends transforming health and medicine.

Wireless Instrumentation Systems for Flight Testing at NASA AFRC

NASA Technical Reports Server (NTRS)

Hang, Richard

2017-01-01

NASA Armstrong Flight Research Center is revolutionizing its traditional wired instrumentation systems with wireless technologies. This effort faces many technical challenges, such as spectrum compliance, time synchronization, power distribution and airworthiness. This presentation summarizes NASA AFRC's flight test capabilities with current conventional instrumentation methodology and highlights the technical challenges of wireless systems used for flight test research applications.

Background review for diagnostic test development for Zika virus infection.

PubMed

Charrel, Rémi N; Leparc-Goffart, Isabelle; Pas, Suzan; de Lamballerie, Xavier; Koopmans, Marion; Reusken, Chantal

2016-08-01

To review the state of knowledge about diagnostic testing for Zika virus infection and identify areas of research needed to address the current gaps in knowledge. We made a non-systematic review of the published literature about Zika virus and supplemented this with information from commercial diagnostic test kits and personal communications with researchers in European preparedness networks. The review covered current knowledge about the geographical spread, pathogen characteristics, life cycle and infection kinetics of the virus. The available molecular and serological tests and biosafety issues are described and discussed in the context of the current outbreak strain. We identified the following areas of research to address current knowledge gaps: (i) an urgent assessment of the laboratory capacity and capability of countries to detect Zika virus; (ii) rapid and extensive field validation of the available molecular and serological tests in areas with and without Zika virus transmission, with a focus on pregnant women; (iii) monitoring the genomic diversity of circulating Zika virus strains; (iv) prospective studies into the virus infection kinetics, focusing on diagnostic sampling (specimen types, combinations and timings); and (v) developing external quality assessments for molecular and serological testing, including differential diagnosis for similar viruses and symptom clusters. The availability of reagents for diagnostic development (virus strains and antigens, quantified viral ribonucleic acid) needs to be facilitated. An international laboratory response is needed, including preparation of protocols for prospective studies to address the most pressing information needs.

Background review for diagnostic test development for Zika virus infection

PubMed Central

Charrel, Rémi N; Leparc-Goffart, Isabelle; Pas, Suzan; de Lamballerie, Xavier; Koopmans, Marion; Reusken, Chantal

2016-01-01

Abstract Objective To review the state of knowledge about diagnostic testing for Zika virus infection and identify areas of research needed to address the current gaps in knowledge. Methods We made a non-systematic review of the published literature about Zika virus and supplemented this with information from commercial diagnostic test kits and personal communications with researchers in European preparedness networks. The review covered current knowledge about the geographical spread, pathogen characteristics, life cycle and infection kinetics of the virus. The available molecular and serological tests and biosafety issues are described and discussed in the context of the current outbreak strain. Findings We identified the following areas of research to address current knowledge gaps: (i) an urgent assessment of the laboratory capacity and capability of countries to detect Zika virus; (ii) rapid and extensive field validation of the available molecular and serological tests in areas with and without Zika virus transmission, with a focus on pregnant women; (iii) monitoring the genomic diversity of circulating Zika virus strains; (iv) prospective studies into the virus infection kinetics, focusing on diagnostic sampling (specimen types, combinations and timings); and (v) developing external quality assessments for molecular and serological testing, including differential diagnosis for similar viruses and symptom clusters. The availability of reagents for diagnostic development (virus strains and antigens, quantified viral ribonucleic acid) needs to be facilitated. Conclusion An international laboratory response is needed, including preparation of protocols for prospective studies to address the most pressing information needs. PMID:27516635

Enhancing the usability of CRT displays in test flight monitoring

NASA Astrophysics Data System (ADS)

Granaas, Michael M.; Sredinski, Victoria E.

1991-01-01

Enhancing the usability of Mission Control Center (MCC) CRT displays stands to improve the quality, productivity, and safety of flight-test research at the NASA Ames-Dryden Flight Research Facility. The results of this research suggests that much can be done to assist the user and improve the quality of flight research through the enhancement of current displays. This research has applications to a variety of flight data monitoring displays.

Cancer Technology - Cancer Currents Blog

Cancer.gov

Blog posts on technologies that affect cancer research and care—including new technologies for detecting cancer, testing treatments, storing/analyzing data, and improving patient care—from NCI Cancer Currents.

Anticipated motivation for genetic testing among smokers, nonsmokers, and former smokers: an exploratory qualitative study of decision making.

PubMed

Giordimaina, Alicia M; Sheldon, Jane P; Petty, Elizabeth M

2014-01-01

This qualitative study explores the public's interest in genetic testing related to cigarette smoking, comparing the public's motivations with researchers' intentions for this technology. Adult nonsmokers (n=463), former smokers (n=163), and current smokers (n=129) completed an online survey. Within a hypothetical scenario, respondents decided whether they desired genetic testing related to smoking and explained their decision making. A non-parametric Kruskal-Wallis test was used to compare the interest in genetic testing by smoking history group. Inductive content analysis was used to investigate respondents' explanations for their testing decisions. Most nonsmokers (64%) and former smokers (58%) did not want genetic testing. While most current daily smokers were interested in testing (56%), most current occasional smokers were not (52%). Respondents' decision-making explanations were categorized into 3 major themes: Causality, Relevancy and Utility (e.g. personal benefits or harms). The use of causality, relevancy and utility explanations varied by smoking history. Notable perceived benefits of testing included recreation and altruism. Notable perceived harms included fear of fatalistic thoughts and concern about genetic discrimination. Interest in genetic testing was highest among current daily smokers, despite potential utility in other groups. Although respondents' motivations for testing paralleled researchers' intentions of tailoring smoking cessation therapies and increasing motivation to quit or abstain, respondents also raised alternative motivations and fears that healthcare providers would need to address. © 2014 S. Karger AG, Basel.

Does Test Anxiety Induce Measurement Bias in Cognitive Ability Tests?

ERIC Educational Resources Information Center

Reeve, Charlie L.; Bonaccio, Silvia

2008-01-01

Although test anxiety is typically negatively related to performance on cognitive ability tests, little research has systematically investigated whether differences in test anxiety result in measurement bias on cognitive ability tests. The current paper uses a structural equation modeling technique to explicitly test for measurement bias due to…

Embryonic stem cells and the next generation of developmental toxicity testing.

PubMed

Kugler, Josephine; Huhse, Bettina; Tralau, Tewes; Luch, Andreas

2017-08-01

The advent of stem cell technology has seen the establishment of embryonic stem cells (ESCs) as molecular model systems and screening tools. Although ESCs are nowadays widely used in research, regulatory implementation for developmental toxicity testing is pending. Areas Covered: This review evaluates the performance of current ESC, including human (h)ESC testing systems, trying to elucidate their potential for developmental toxicity testing. It shall discuss defining parameters and mechanisms, their relevance and contemplate what can realistically be expected. Crucially this includes the question of how to ascertain the quality of currently employed cell lines and tests based thereon. Finally, the use of hESCs will raise ethical concerns which should be addressed early on. Expert Opinion: While the suitability of (h)ESCs as tools for research and development goes undisputed, any routine use for developmental toxicity testing currently still seems premature. The reasons for this comprise inherent biological deficiencies as well as cell line quality and system validation. Overcoming these issues will require collaboration of scientists, test developers and regulators. Also, validation needs to be made worthwhile for academia. Finally we have to continuously rethink existing strategies, making room for improved testing and innovative approaches.

NASA Researcher Adjusts a Travelling Magnetic Wave Plasma Engine

NASA Image and Video Library

1964-02-21

Raymond Palmer, of the Electromagnetic Propulsion Division’s Plasma Flow Section, adjusts the traveling magnetic wave plasma engine being operated in the Electric Power Conversion at the National Aeronautics and Space Administration (NASA) Lewis Research Center. During the 1960s Lewis researchers were exploring several different methods of creating electric propulsion systems, including the traveling magnetic wave plasma engine. The device operated similarly to alternating-current motors, except that a gas, not a solid, was used to conduct the electricity. A magnetic wave induced a current as it passed through the plasma. The current and magnetic field pushed the plasma in one direction. Palmer and colleague Robert Jones explored a variety of engine configurations in the Electric Propulsion Research Building. The engine is seen here mounted externally on the facility’s 5-foot diameter and 16-foot long vacuum tank. The four magnetic coils are seen on the left end of the engine. The researchers conducted two-minute test runs with varying configurations and used of both argon and xenon as the propellant. The Electric Propulsion Research Building was built in 1942 as the Engine Propeller Research Building, often called the Prop House. It contained four test cells to study large reciprocating engines with their propellers. After World War II, the facility was modified to study turbojet engines. By the 1960s, the facility was modified again for electric propulsion research and given its current name.

Revolutionizing Toxicity Testing For Predicting Developmental Outcomes (DNT4)

EPA Science Inventory

Characterizing risk from environmental chemical exposure currently requires extensive animal testing; however, alternative approaches are being researched to increase throughput of chemicals screened, decrease reliance on animal testing, and improve accuracy in predicting adverse...

Update on U.S.EPA Cookstove Research Activities

EPA Science Inventory

The presentation includes background information on EPA's stove research, focuses on cookstove testing for air pollutant emissions and energy efficiency, and briefly describes current research activities. Ongoing activities are highlighted, and EPA contacts are provided.

Toward Future Flight.

ERIC Educational Resources Information Center

Aviation/Space, 1982

1982-01-01

Current aeronautical research is highlighted, focusing on tilt rotor aircraft, quiet short-haul jets, HiMAT (Highly Maneuverable Aircraft Technology), pivoting wing aircraft, energy absorption tests, and lightning research. (JN)

Development and Testing of High Current Hollow Cathodes for High Power Hall Thrusters

NASA Technical Reports Server (NTRS)

Kamhawi, Hani; Van Noord, Jonathan

2012-01-01

NASA's Office of the Chief Technologist In-Space Propulsion project is sponsoring the testing and development of high power Hall thrusters for implementation in NASA missions. As part of the project, NASA Glenn Research Center is developing and testing new high current hollow cathode assemblies that can meet and exceed the required discharge current and life-time requirements of high power Hall thrusters. This paper presents test results of three high current hollow cathode configurations. Test results indicated that two novel emitter configurations were able to attain lower peak emitter temperatures compared to state-of-the-art emitter configurations. One hollow cathode configuration attained a cathode orifice plate tip temperature of 1132 degC at a discharge current of 100 A. More specifically, test and analysis results indicated that a novel emitter configuration had minimal temperature gradient along its length. Future work will include cathode wear tests, and internal emitter temperature and plasma properties measurements along with detailed physics based modeling.

Space technology test facilities at the NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Gross, Anthony R.; Rodrigues, Annette T.

1990-01-01

The major space research and technology test facilities at the NASA Ames Research Center are divided into five categories: General Purpose, Life Support, Computer-Based Simulation, High Energy, and the Space Exploraton Test Facilities. The paper discusses selected facilities within each of the five categories and discusses some of the major programs in which these facilities have been involved. Special attention is given to the 20-G Man-Rated Centrifuge, the Human Research Facility, the Plant Crop Growth Facility, the Numerical Aerodynamic Simulation Facility, the Arc-Jet Complex and Hypersonic Test Facility, the Infrared Detector and Cryogenic Test Facility, and the Mars Wind Tunnel. Each facility is described along with its objectives, test parameter ranges, and major current programs and applications.

Current and future use of point-of-care tests in primary care: an international survey in Australia, Belgium, The Netherlands, the UK and the USA

PubMed Central

Howick, Jeremy; Cals, Jochen W L; Jones, Caroline; Price, Christopher P; Plüddemann, Annette; Heneghan, Carl; Berger, Marjolein Y; Buntinx, Frank; Hickner, John; Pace, Wilson; Badrick, Tony; Van den Bruel, Ann; Laurence, Caroline; van Weert, Henk C; van Severen, Evie; Parrella, Adriana; Thompson, Matthew

2014-01-01

Objective Despite the growing number of point-of-care (POC) tests available, little research has assessed primary care clinician need for such tests. We therefore aimed to determine which POC tests they actually use or would like to use (if not currently available in their practice). Design Cross-sectional survey. Setting Primary care in Australia, Belgium (Flanders region only), the Netherlands, the UK and the USA. Participants Primary care doctors (general practitioners, family physicians). Main measures We asked respondents to (1) identify conditions for which a POC test could help inform diagnosis, (2) from a list of tests provided: evaluate which POC tests they currently use (and how frequently) and (3) determine which tests (from that same list) they would like to use in the future (and how frequently). Results 2770 primary care clinicians across five countries responded. Respondents in all countries wanted POC tests to help them diagnose acute conditions (infections, acute cardiac disease, pulmonary embolism/deep vein thrombosis), and some chronic conditions (diabetes, anaemia). Based on the list of POC tests provided, the most common tests currently used were: urine pregnancy, urine leucocytes or nitrite and blood glucose. The most commonly reported tests respondents expressed a wish to use in the future were: D-dimer, troponin and chlamydia. The UK and the USA reported a higher actual and desired use for POC tests than Australia, Belgium and the Netherlands. Our limited data suggest (but do not confirm) representativeness. Conclusions Primary care clinicians in all five countries expressed a desire for POC tests to help them diagnose a range of acute and chronic conditions. Rates of current reported use and desired future use were generally high for a small selection of POC tests, but varied across countries. Future research is warranted to explore how specific POC tests might improve primary care. PMID:25107438

Audio Adapted Assessment Data: Does the Addition of Audio to Written Items Modify the Item Calibration?

ERIC Educational Resources Information Center

Snyder, James

2010-01-01

This dissertation research examined the changes in item RIT calibration that occurred when adding audio to a set of currently calibrated RIT items and then placing these new items as field test items in the modified assessments on the NWEA MAP test platform. The researcher used test results from over 600 students in the Poway School District in…

Job Analysis Results for Malicious-Code Reverse Engineers: A Case Study

DTIC Science & Technology

2014-05-01

Testing in Personnel Selection: Contemporary Issues in Cognitive Ability and Personality Testing .” Journal of Business Inquiry: Research , Edu- cation, and...federally funded research and development center. Any opinions, findings and conclusions or recommendations expressed in this material are those of...predict the develop- ment of expertise is important. Currently, job analysis research on teams of malicious-code re- verse engineers is lacking. Therefore

The Impact Analysis of Psychological Reliability of Population Pilot Study for Selection of Particular Reliable Multi-Choice Item Test in Foreign Language Research Work

ERIC Educational Resources Information Center

Fazeli, Seyed Hossein

2010-01-01

The purpose of research described in the current study is the psychological reliability, its importance, application, and more to investigate on the impact analysis of psychological reliability of population pilot study for selection of particular reliable multi-choice item test in foreign language research work. The population for subject…

Comparisons between vehicular emissions from real-world in-use testing and EPA moves estimation.

DOT National Transportation Integrated Search

2012-07-01

"This research study developed a methodology to perform mandatory dynamometer vehicular emissions tests : on real roads, performed on-road emissions tests, and compared the test results to the estimates using the : current EPA emissions estimation mo...

Empowerment through agency-promoting dialogue: an explicit application of harm reduction theory to reframe HIV test counseling.

PubMed

Mattson, M

2000-01-01

The counseling that accompanies HIV testing can be an important prevention tool for encouraging people to practice safer sex to avoid AIDS, but there is scant research about how HIV test counseling operates in practice. This article critiques the current Centers for Disease Control and Prevention (CDC) protocol for HIV test counseling for not being genuinely client centered and ignoring the unique needs of clients and offers an alternative approach that adapts and explicitly applies the tenets of harm reduction theory (HRT). Excerpts from actual HIV test counseling sessions illustrate both the weaknesses in the current approach to HIV test counseling and project how the alternative theoretical perspective offered could provide counseling that encourages agency-promoting and empowering dialogue. The implications for the development of HRT as a health communication heuristic and a practical training and evaluation strategy are discussed along with limitations and future research directions.

Detection of Test Collusion via Kullback-Leibler Divergence

ERIC Educational Resources Information Center

Belov, Dmitry I.

2013-01-01

The development of statistical methods for detecting test collusion is a new research direction in the area of test security. Test collusion may be described as large-scale sharing of test materials, including answers to test items. Current methods of detecting test collusion are based on statistics also used in answer-copying detection.…

Public Health Genomics and Genetic Test Evaluation: The Challenge of Conducting Behavioural Research on the Utility of Lifestyle-Genetic Tests

PubMed Central

Sanderson, Saskia C.; Wardle, Jane; Humphries, Steve E.

2008-01-01

Human genetics research is increasingly concerned with multifactorial conditions such as diabetes and heart disease, which are influenced not only by genetic but also lifestyle factors such as diet and smoking. Although the results of ‘lifestyle-genetic’ tests using this information could conceivably motivate lifestyle changes in the future, companies are already selling such tests and related lifestyle advice commercially. Some academics and lobby groups have condemned the companies for selling these tests in advance of scientific support. Others are concerned that the tests may not motivate lifestyle improvements, instead causing distress in people receiving adverse test results and complacency in those receiving reassuring results. There is currently no regulatory oversight of genetic test utility, despite consensus in the Public Health Genomics community that clinical utility (including psychological and behavioural impact) of all emerging genetic tests should be evaluated before being introduced for individual use. Clearly, empirical data in this area is much needed, to inform understanding of the potential utility of these tests, and of whether stricter regulation of commercial exploitation is needed. In this article, we review the current situation regarding lifestyle-genetic tests, and discuss the challenges inherent in conducting this kind of behavioural research in the genomics era. PMID:19776630

The Effect of Situated Learning on Students Vocational English Learning

ERIC Educational Resources Information Center

Özüdogru, Melike; Özüdogru, Fatma

2017-01-01

The current study aimed to find out the effect of situated learning on students' Vocational English learning. This research employed a mixed method research design. In the quantitative part of the study, pre-tests and post-tests were implemented to investigate the differences in students' vocational English learning between the experimental and…

Design of experiments enhanced statistical process control for wind tunnel check standard testing

NASA Astrophysics Data System (ADS)

Phillips, Ben D.

The current wind tunnel check standard testing program at NASA Langley Research Center is focused on increasing data quality, uncertainty quantification and overall control and improvement of wind tunnel measurement processes. The statistical process control (SPC) methodology employed in the check standard testing program allows for the tracking of variations in measurements over time as well as an overall assessment of facility health. While the SPC approach can and does provide researchers with valuable information, it has certain limitations in the areas of process improvement and uncertainty quantification. It is thought by utilizing design of experiments methodology in conjunction with the current SPC practices that one can efficiently and more robustly characterize uncertainties and develop enhanced process improvement procedures. In this research, methodologies were developed to generate regression models for wind tunnel calibration coefficients, balance force coefficients and wind tunnel flow angularities. The coefficients of these regression models were then tracked in statistical process control charts, giving a higher level of understanding of the processes. The methodology outlined is sufficiently generic such that this research can be applicable to any wind tunnel check standard testing program.

Python Scripts for Automation of Current-Voltage Testing of Semiconductor Devices (FY17)

DTIC Science & Technology

2017-01-01

ARL-TR-7923 ● JAN 2017 US Army Research Laboratory Python Scripts for Automation of Current- Voltage Testing of Semiconductor...manual device-testing procedures is reduced or eliminated through automation. This technical report includes scripts written in Python , version 2.7, used ...nothing. 3.1.9 Exit Program The script exits the entire program. Line 505, sys.exit(), uses the sys package that comes with Python to exit system

Research on resistance characteristics of YBCO tape under short-time DC large current impact

NASA Astrophysics Data System (ADS)

Zhang, Zhifeng; Yang, Jiabin; Qiu, Qingquan; Zhang, Guomin; Lin, Liangzhen

2017-06-01

Research of the resistance characteristics of YBCO tape under short-time DC large current impact is the foundation of the developing DC superconducting fault current limiter (SFCL) for voltage source converter-based high voltage direct current system (VSC-HVDC), which is one of the valid approaches to solve the problems of renewable energy integration. SFCL can limit DC short-circuit and enhance the interrupting capabilities of DC circuit breakers. In this paper, under short-time DC large current impacts, the resistance features of naked tape of YBCO tape are studied to find the resistance - temperature change rule and the maximum impact current. The influence of insulation for the resistance - temperature characteristics of YBCO tape is studied by comparison tests with naked tape and insulating tape in 77 K. The influence of operating temperature on the tape is also studied under subcooled liquid nitrogen condition. For the current impact security of YBCO tape, the critical current degradation and top temperature are analyzed and worked as judgment standards. The testing results is helpful for in developing SFCL in VSC-HVDC.

Half a Congress--Half a Loaf.

ERIC Educational Resources Information Center

Florio, David H.

1980-01-01

Summarizes current congressional action affecting educational research and related activities, including appropriations, the Higher Education Act reauthorization, a new research and technology act, and legislation regarding educational testing, youth unemployment and training, paperwork and red tape reduction, and research privacy. (GC)

Modelling of eddy currents related to large angle magnetic suspension test fixture

NASA Technical Reports Server (NTRS)

Britcher, Colin P.; Foster, Lucas E.

1994-01-01

This report presents a preliminary analysis of the mathematical modelling of eddy current effects in a large-gap magnetic suspension system. It is shown that eddy currents can significantly affect the dynamic behavior and control of these systems, but are amenable to measurement and modelling. A theoretical framework is presented, together with a comparison of computed and experimental data related to the Large Angle Magnetic Suspension Test Fixture at NASA Langley Research Center.

ER-2 High Altitude Solar Cell Calibration Flights

NASA Technical Reports Server (NTRS)

Myers, Matthew; Wolford, David; Snyder, David; Piszczor, Michael

2015-01-01

Evaluation of space photovoltaics using ground-based simulators requires primary standard cells which have been characterized in a space or near-space environment. Due to the high cost inherent in testing cells in space, most primary standards are tested on high altitude fixed wing aircraft or balloons. The ER-2 test platform is the latest system developed by the Glenn Research Center (GRC) for near-space photovoltaic characterization. This system offers several improvements over GRC's current Learjet platform including higher altitude, larger testing area, onboard spectrometers, and longer flight season. The ER-2 system was developed by GRC in cooperation with NASA's Armstrong Flight Research Center (AFRC) as well as partners at the Naval Research Laboratory and Air Force Research Laboratory. The system was designed and built between June and September of 2014, with the integration and first flights taking place at AFRC's Palmdale facility in October of 2014. Three flights were made testing cells from GRC as well as commercial industry partners. Cell performance data was successfully collected on all three flights as well as solar spectra. The data was processed using a Langley extrapolation method, and performance results showed a less than half a percent variation between flights, and less than a percent variation from GRC's current Learjet test platform.

Performance improvement of a measurement station for superconducting cable test

NASA Astrophysics Data System (ADS)

Arpaia, Pasquale; Bottura, Luca; Montenero, Giuseppe; Naour, Sandrine Le

2012-09-01

A fully digital system, improving measurements flexibility, integrator drift, and current control of superconducting transformers for cable test, is proposed. The system is based on a high-performance integration of Rogowski coil signal and a flexible direct control of the current into the secondary windings. This allows state-of-the-art performance to be overcome by means of out-of-the-shelf components: on a full-scale of 32 kA, current measurement resolution of 1 A, stability below 0.25 A min-1, and controller ripple less than ±50 ppm. The system effectiveness has been demonstrated experimentally on the superconducting transformer of the Facility for the Research of Superconducting Cables at the European Organization for Nuclear Research (CERN).

Calibration Laboratory Capabilities Listing as of April 2009

NASA Technical Reports Server (NTRS)

Kennedy, Gary W.

2009-01-01

This document reviews the Calibration Laboratory capabilities for various NASA centers (i.e., Glenn Research Center and Plum Brook Test Facility Kennedy Space Center Marshall Space Flight Center Stennis Space Center and White Sands Test Facility.) Some of the parameters reported are: Alternating current, direct current, dimensional, mass, force, torque, pressure and vacuum, safety, and thermodynamics parameters. Some centers reported other parameters.

Current and Emerging Technology Approaches in Genomics

PubMed Central

Conley, Yvette P.; Biesecker, Leslie G.; Gonsalves, Stephen; Merkle, Carrie J.; Kirk, Maggie; Aouizerat, Bradley E.

2013-01-01

Purpose To introduce current and emerging approaches that are being utilized in the field of genomics so the reader can conceptually evaluate the literature and appreciate how these approaches are advancing our understanding of health-related issues. Organizing Construct Each approach is described and includes information related to how it is advancing research, its potential clinical utility, exemplars of current uses, challenges related to technologies used for these approaches, and when appropriate information related to understanding the evidence base for clinical utilization of each approach is provided. Web-based resources are included for the reader who would like more in-depth information and to provide opportunity to stay up to date with these approaches and their utility. Conclusions The chosen approaches– genome sequencing, genome-wide association studies, epigenomics, and gene expression– are extremely valuable approaches for collecting research data to help us better understand the pathophysiology of a variety of health-related conditions, but they are also gaining in utility for clinical assessment and testing purposes. Clinical Relevance Our increased understanding of the molecular underpinnings of disease will assist with better development of screening tests, diagnostic tests, tests that allow us to prognosticate, tests that allow for individualized treatments, and tests to facilitate post-treatment surveillance. PMID:23294727

International Low-Earth-Orbit Spacecraft Materials Test Program Initiated for Better Prediction of Durability and Performance

NASA Technical Reports Server (NTRS)

Rutledge, Sharon K.

1999-01-01

Spacecraft in low Earth orbit (LEO) are subjected to many components of the environment, which can cause them to degrade much more rapidly than intended and greatly shorten their functional life. The atomic oxygen, ultraviolet radiation, and cross contamination present in LEO can affect sensitive surfaces such as thermal control paints, multilayer insulation, solar array surfaces, and optical surfaces. The LEO Spacecraft Materials Test (LEO-SMT) program is being conducted to assess the effects of simulated LEO exposure on current spacecraft materials to increase understanding of LEO degradation processes as well as to enable the prediction of in-space performance and durability. Using ground-based simulation facilities to test the durability of materials currently flying in LEO will allow researchers to compare the degradation evidenced in the ground-based facilities with that evidenced on orbit. This will allow refinement of ground laboratory test systems and the development of algorithms to predict the durability and performance of new materials in LEO from ground test results. Accurate predictions based on ground tests could reduce development costs and increase reliability. The wide variety of national and international materials being tested represent materials being functionally used on spacecraft in LEO. The more varied the types of materials tested, the greater the probability that researchers will develop and validate predictive models for spacecraft long-term performance and durability. Organizations that are currently participating in the program are ITT Research Institute (USA), Lockheed Martin (USA), MAP (France), SOREQ Nuclear Research Center (Israel), TNO Institute of Applied Physics (The Netherlands), and UBE Industries, Ltd. (Japan). These represent some of the major suppliers of thermal control and sensor materials currently flying in LEO. The participants provide materials that are exposed to selected levels of atomic oxygen, vacuum ultraviolet radiation, contamination, or synergistic combined environments at the NASA Lewis Research Center. Changes in characteristics that could affect mission performance or lifetime are then measured. These characteristics include changes in mass, solar absorptance, and thermal emittance. The durability of spacecraft materials from U.S. suppliers is then compared with those of materials from other participating countries. Lewis will develop and validate performance and durability prediction models using this ground data and available space data. NASA welcomes the opportunity to consider additional international participants in this program, which should greatly aid future spacecraft designers as they select materials for LEO missions.

An overview of passenger equipment full-scale impact tests

DOT National Transportation Integrated Search

2003-10-07

As part of the Federal Railroad Administrations Equipment Safety Research Program, a series of full-scale impact tests are being conducted on rail passenger vehicles. Four types of tests are intended to define the performance of current-design equ...

An overview of passenger equipment fullscale impact tests : results to date

DOT National Transportation Integrated Search

2001-11-25

As part of the Federal Railroad Administrations Equipment Safety Research Program, a series of full-scale impact tests are being conducted on rail passenger vehicles. Three tests are intended to define the performance of current-design equipment i...

Current ethical and legal issues in health-related direct-to-consumer genetic testing.

PubMed

Niemiec, Emilia; Kalokairinou, Louiza; Howard, Heidi Carmen

2017-09-01

A variety of health-related genetic testing is currently advertized directly to consumers. This article provides a timely overview of direct-to-consumer genetic testing (DTC GT) and salient ethical issues, as well as an analysis of the impact of the recently adopted regulation on in vitro diagnostic medical devices on DTC GT. DTC GT companies currently employ new testing approaches, report on a wide spectrum of conditions and target new groups of consumers. Such activities raise ethical issues including the questionable analytic and clinical validity of tests, the adequacy of informed consent, potentially misleading advertizing, testing in children, research uses and commercialization of genomic data. The recently adopted regulation on in vitro diagnostic medical devices may limit the offers of predisposition DTC GT in the EU market.

Testing of the Advanced Stirling Radioisotope Generator Engineering Unit at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Lewandowski, Edward J.

2013-01-01

The Advanced Stirling Radioisotope Generator (ASRG) is a high-efficiency generator being developed for potential use on a Discovery 12 space mission. Lockheed Martin designed and fabricated the ASRG Engineering Unit (EU) under contract to the Department of Energy. This unit was delivered to NASA Glenn Research Center in 2008 and has been undergoing extended operation testing to generate long-term performance data for an integrated system. It has also been used for tests to characterize generator operation while varying control parameters and system inputs, both when controlled with an alternating current (AC) bus and with a digital controller. The ASRG EU currently has over 27,000 hours of operation. This paper summarizes all of the tests that have been conducted on the ASRG EU over the past 3 years and provides an overview of the test results and what was learned.

Development and Application of Intelligence Tests for the Blind: A Research Utilization Conference. Final Report.

ERIC Educational Resources Information Center

Curtis, W. Scott

The purpose of this project was to inquire into the current status of development, past use, availability, and future planning of intelligence tests for the visually handicapped in relation to the fields of psychological, educational, and vocational counseling. The project procedure was that of a research utilization conference involving the…

Why Do Rereading Lag Effects Depend on Test Delay?

ERIC Educational Resources Information Center

Rawson, Katherine A.

2012-01-01

In previous research, rereading after a long lag versus a short lag led to greater performance on delayed tests but not on immediate tests. The current study tested two accounts of why the effects of rereading lag depend on test delay. The "levels of representation" ("LOR") "hypothesis" states that the effects reflect…

Final Technical Report: Electromagnetic Pump Insulation Materials Development and Testing (PLM-DOC-0005-2465) Report # DOEGEHB00613

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krahn, John; Reed, Claude; Loewen, Eric

Final Technical Report: Electromagnetic Pump Insulation Materials Development and Testing (Report # DOEGEHB00613) summarizes the information gathered from the analysis of the 160 m3/min EM Pump insulation that was tested in 2000-2002 and additional evaluations of new resilient, engineered insulation system evaluated and tested at both GRC and ANL. This report provides information on Tasks 1 and 2 of the entire project. This report also provides information in three broad areas: Historical and current data; Conclusions based on test data; and Insulation specifications for use in EM Pumps. The research for Task 2 builds upon Task 1: Update EM Pumpmore » Databank, which is summarized within this report. Where research for Task 3 and 4 Next-Generation EM Pump Analysis Tools identified parameters or analysis model that benefits Task 2 research, those items are noted within this report. The important design variables for the manufacture and operation of an EM Pump that the insulation research can evaluate are: space constraints; voltage capability of insulation system; maximum flux density through iron; flow rate and outlet pressure; efficiency and manufacturability. The development summary of the Electromagnetic Pump Insulation Materials Development and Testing was completed to include: Historical and current data; Conclusions based on test data; and Insulation specifications for use in EM Pumps.« less

Testing and characterizations of infrared sensor over the temperature range of 2 Kelvin to 300 Kelvin

NASA Technical Reports Server (NTRS)

Hansen, R. G.

1983-01-01

Various cryogenic techniques were used to evaluate state of the art electro-optic devices. As research, development, and production demands require more sensitive testing techniques, faster test results, and higher production throughput, the emphasis on supporting cryogenic systems increases. The three traditional methods currently utilized in electro-optic device testing are discussed: (1) liquid contaiment dewars; (2) liquid transfer systems; and (3) closed cycle refrigeration systems. Advantages, disadvantages, and the current state of the art of each of these cryogenic techniques is discussed.

Effect of current and speed on porosity in autogenous Tungsten Inert Gas (TIG) welding of aluminum alloys A1100 butt joint

NASA Astrophysics Data System (ADS)

Milyardi, Indra; Sunar Baskoro, Ario

2018-04-01

Autogenous Tungsten Inert Gas (TIG) welding has been conducted on aluminum alloy A1100. The purpose of this research is to determine the proper current and speed of autogenous TIG welding with butt joint pattern. Variations on welding current are 150 A, 155 A, and 160 A with the variations on welding speed are 1 mm/seconds, 1.1 mm/seconds, 1.2 mm/seconds. The welded results were tested using non-destructive test (NDT) method using X-Ray radiography. After the test, it is found that the appropriate current for the best result without porosity can be achieved using the welding parameter of welding current of 160 A and the welding speed of 1.1 mm seconds.

Evaluation of dynamic shear rheometer tests for emulsions : research project capsule.

DOT National Transportation Integrated Search

2010-10-01

Currently, the Louisiana Department of Transportation and Development (LADOTD) : requires ductility tests at 25C according to AASHTO T51 for emulsions and two : other tests, namely force ductility ratio at 4C and elastic recovery at 10C : accor...

USING PEA AND SOYBEAN IN DEVELOPMENTAL TESTS FOR NON-TARGET PLANT EFFECTS

EPA Science Inventory

Current tests required for pesticide registration do not investigate the potential effects of chemical exposure on plant development. The tests investigate only seedling emergence and early growth. Previous research has shown that significant impacts can occur to plant developm...

Development and proposed implementation of a field permeability test for a asphalt concrete.

DOT National Transportation Integrated Search

2001-07-01

The objectives of this study were as follows: : 1) To review research performed by others and determine the state-of-the-art of field permeability measurements; : 2) To review current laboratory permeability testing devices and their testing procedur...

Testing technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-10-01

This bulletin from Sandia National Laboratories presents current research highlights in testing technology. Ion microscopy offers new nondestructive testing technique that detects high resolution invisible defects. An inexpensive thin-film gauge checks detonators on centrifuge. Laser trackers ride the range and track helicopters at low-level flights that could not be detected by radar. Radiation transport software predicts electron/photon effects via cascade simulation. Acoustic research in noise abatement will lead to quieter travelling for Bay Area Rapid Transport (BART) commuters.

HIV pre-test information, discussion or counselling? A review of guidance relevant to the WHO European Region.

PubMed

Bell, Stephen A; Delpech, Valerie; Raben, Dorthe; Casabona, Jordi; Tsereteli, Nino; de Wit, John

2016-02-01

In the context of a shift from exceptionalism to normalisation, this study examines recommendations/evidence in current pan-European/global guidelines regarding pre-test HIV testing and counselling practices in health care settings. It also reviews new research not yet included in guidelines. There is consensus that verbal informed consent must be gained prior to testing, individually, in private, confidentially, in the presence of a health care provider. All guidelines recommend pre-test information/discussion delivered verbally or via other methods (information sheet). There is agreement about a minimum standard of information to be provided before a test, but guidelines differ regarding discussion about issues encouraging patients to think about implications of the result. There is heavy reliance on expert consultation in guideline development. Referenced scientific evidence is often more than ten years old and based on US/UK research. Eight new papers are reviewed. Current HIV testing and counselling guidelines have inconsistencies regarding the extent and type of information that is recommended during pre-test discussions. The lack of new research underscores a need for new evidence from a range of European settings to support the process of expert consultation in guideline development. © The Author(s) 2015.

Employing Design and Development Research (DDR): Approaches in the Design and Development of Online Arabic Vocabulary Learning Games Prototype

ERIC Educational Resources Information Center

Sahrir, Muhammad Sabri; Alias, Nor Aziah; Ismail, Zawawi; Osman, Nurulhuda

2012-01-01

The design and development research, first proposed by Brown and Collins in the 1990s, is currently among the well-known methods in educational research to test theory and validate its practicality. The method is also known as developmental research, design research, design-based research, formative research and design-cased and possesses…

Fabrication and physical testing of graphite composite panels utilizing woven graphite fabric with current and advanced state-of-the-art resin systems

NASA Technical Reports Server (NTRS)

Lee, S. C. S.

1979-01-01

Three weaves were evaluated; a balanced plain weave, a balanced 8-harness satin weave, and a semiunidirectional crowfoot satin weave. The current state-of-the-art resin system selected was Fiberite's 934 Epoxy; the advanced resin systems evaluated were Phenolic, Phenolic/Novolac, Benzyl and Bismaleimide. The panels were fabricated for testing on NASA/Ames Research Center's Composites Modification Program. Room temperature mechanical tests only were performed by Hitco; the results are presented.

Baseline and Verification Tests of the Electric Vehicle Associates’ Current Fare Station Wagon.

DTIC Science & Technology

1983-01-01

ELECTRIC Final Test Report VEICLE ASSOCIATES’CURRENT FARE STATION WAGON 27 March 1980 -6 November 1981 6. PERFORMING ORG. REPORT NUMBER * .7. AUTNOR(s) a...Whe,% Doe. Er(,rrrd) -I PREFACE Z..1~ The electric and hybrid vehicle test was conducted by the U.S. Army Mobility Equipment Research and Development...COAST-DOWN D. ELECTRIC AND HYBRID VEHICLE 92 VERIFICATION PROCEDURES 1".f S. -..°.o. . *-.. .,". .. " . ,. . . . . . . % % %d° ILLUSTRATIONS Figure

Exposure Science for Chemical Prioritization and Toxicity Testing

EPA Science Inventory

Currently, a significant research effort is underway to apply new technologies to screen and prioritize chemicals for toxicity testing as well as to improve understanding of toxicity pathways (Dix et al. 2007, Toxicol Sci; NRC, 2007, Toxicity Testing in the 21st Century; Collins ...

Acoustic flight test of the Piper Lance

DOT National Transportation Integrated Search

1986-12-01

Research is being conducted to refine current noise regulation of propeller-driven small airplanes. Studies are examining the prospect of a substituting a takeoff procedure of equal stringency for the level flyover certification test presently requir...

Design Science Research toward Designing/Prototyping a Repeatable Model for Testing Location Management (LM) Algorithms for Wireless Networking

ERIC Educational Resources Information Center

Peacock, Christopher

2012-01-01

The purpose of this research effort was to develop a model that provides repeatable Location Management (LM) testing using a network simulation tool, QualNet version 5.1 (2011). The model will provide current and future protocol developers a framework to simulate stable protocol environments for development. This study used the Design Science…

Structural Equation Modeling in Language Testing and Learning Research: A Review

ERIC Educational Resources Information Center

In'nami, Yo; Koizumi, Rie

2011-01-01

Despite the recent increase of structural equation modeling (SEM) in language testing and learning research and Kunnan's (1998) call for the proper use of SEM to produce useful findings, there seem to be no reviews about how SEM is applied in these areas or about the extent to which the current application accords with appropriate practices. To…

The Value and Need for Research on the History of the Educational Research and Measurements Movements.

ERIC Educational Resources Information Center

Engelhart, Max D.

The theory and practice of education have been profoundly influenced since 1900 by the educational research and the educational testing movements. These movements deserve greatly increased historical research. Many current innovations in education have been tried in the past and found wanting. Study of the pioneer educational researches reveals…

An Alternative Approach to Identifying a Dimension in Second Language Proficiency.

ERIC Educational Resources Information Center

Griffin, Patrick E.; And Others

Current practice in language testing has not yet integrated classical test theory with assessment of language skills. In addition, language testing needs to be part of theory development. Lack of sound testing procedures can lead to problems in research design and ultimately, inappropriate theory development. The debate over dimensionality of…

77 FR 16846 - Published Privacy Impact Assessments on the Web

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... Security Advanced Research Projects Agency (HSARPA), S&T Directorate seeks to develop physiological and behavioral screening technologies that will enable security officials to test the effectiveness of current... FAST research is adding a new type of research, the Passive Methods for Precision Behavioral Screening...

The cost of genetic testing for ocular disease: who pays?

PubMed

Capasso, Jenina E

2014-09-01

To facilitate ophthalmologists' understanding on the cost of genetic testing in ocular disease, the complexities of insurance coverage and its impact on the availability of testing. Many insurance carriers address coverage for genetic testing in written clinical policies. They provide criteria for medically necessary testing. These policies mostly cover testing for individuals who are symptomatic and in whom testing will have a direct impact on medical treatment. In cases in which no treatments are currently available, other than research trials, patients may have difficulty in getting insurance coverage for genetic testing. Genetic testing for inherited eye diseases can be costly but has many benefits to patient care, including confirmation of a diagnosis, insight into prognostic information, and identification of associated health risks, inheritance patterns, and possible current and future treatments. As gene therapy advances progress, the availability for treatment in ocular diseases, coverage for genetic testing by third-party payers could increase on the basis of current clinical policies.

Suicide risk factors for young adults: testing a model across ethnicities.

PubMed

Gutierrez, P M; Rodriguez, P J; Garcia, P

2001-06-01

A general path model based on existing suicide risk research was developed to test factors contributing to current suicidal ideation in young adults. A sample of 673 undergraduate students completed a packet of questionnaires containing the Beck Depression Inventory, Adult Suicidal Ideation Questionnaire, and Multi-Attitude Suicide Tendency Scale. They also provided information on history of suicidality and exposure to attempted and completed suicide in others. Structural equation modeling was used to test the fit of the data to the hypothesized model. Goodness-of-fit indices were adequate and supported the interactive effects of exposure, repulsion by life, depression, and history of self-harm on current ideation. Model fit for three subgroups based on race/ethnicity (i.e., White, Black, and Hispanic) determined that repulsion by life and depression function differently across groups. Implications of these findings for current methods of suicide risk assessment and future research are discussed in the context of the importance of culture.

Ceramics in Restorative and Prosthetic DENTISTRY1

NASA Astrophysics Data System (ADS)

Kelly, J. Robert

1997-08-01

This review is intended to provide the ceramic engineer with information about the history and current use of ceramics in dentistry, contemporary research topics, and potential research agenda. Background material includes intra-oral design considerations, descriptions of ceramic dental components, and the origin, composition, and microstructure of current dental ceramics. Attention is paid to efforts involving net-shape processing, machining as a forming method, and the analysis of clinical failure. A rationale is presented for the further development of all-ceramic restorative systems. Current research topics receiving attention include microstructure/processing/property relationships, clinical failure mechanisms and in vitro testing, wear damage and wear testing, surface treatments, and microstructural modifications. The status of the field is critically reviewed with an eye toward future work. Significant improvements seem possible in the clinical use of ceramics based on engineering solutions derived from the study of clinically failed restorations, on the incorporation of higher levels of "biomimicry" in new systems, and on the synergistic developments in dental cements and adhesive dentin bonding.

Hardware-in-the-loop projector system for light detection and ranging sensor testing

NASA Astrophysics Data System (ADS)

Kim, Hajin J.; Naumann, Charles B.; Cornell, Michael C.

2012-08-01

Efforts in developing a synthetic environment for testing light detection and ranging (LADAR) sensors in a hardware-in-the-loop simulation are continuing at the Aviation and Missile Research, Engineering, and Development Center of the U.S. Army Research, Engineering and Development Command (RDECOM). Current activities have concentrated on evaluating the optical projection techniques for the LADAR synthetic environment. Schemes for generating the optical signals representing the individual pixels of the projection are of particular interest. Several approaches have been investigated and tested with emphasis on operating wavelength, intensity dynamic range and uniformity, and flexibility in pixel waveform generation. This paper will discuss some of the results from these current efforts at RDECOM's System Simulation and Development Directorate's Electro Optical Technology Development Laboratory.

Continuous long-term health monitoring using ultrasonic wave propagation.

DOT National Transportation Integrated Search

2016-12-01

This report presents the findings of a research project on using ultrasonic testing to : continuously monitor reinforced concrete bridge decks for the onset of delamination. The : report first presents a review of current nondestructive testing techn...

Current Status of Concentrator Photovoltaic (CPV) Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philipps, Simon P.; Bett, Andreas W.; Horowitz, Kelsey

2015-12-01

This report summarizes the status of the concentrator photovoltaic (CPV) market and industry as well as current trends in research and technology. This report is intended to guide research agendas for Fraunhofer ISE, the National Renewable Energy Laboratory (NREL), and other R&D organizations. Version 1.1 of this report includes recent progress in CPV. The recent record module efficiency of 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9%more » at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve. 38.9% at Concentrator Standard Test Conditions (CSTC) is an impressive result, demonstrating the continuing opportunity for CPV technology to improve.« less

Developing Organs On-a-Chip: Chemical Safety Research Collaborators Provide Research Review

EPA Pesticide Factsheets

Risk assessors must understand how chemicals impact human systems, including complex tissues and organs. Unfortunately, there are huge data gaps in this area, and current testing methods are costly and time-consuming.

Atlanta congestion reduction demonstration. National evaluation : travel demand management (TDM) data test plan.

DOT National Transportation Integrated Search

2001-01-01

Internet-based Advanced Traveler Information Services (ATIS) provide the urban traveler with estimated travel times based on current roadway congestion. Survey research indicates that the vast majority of current ATIS users are satisfied consumers wh...

Ukrainian Program for Material Science in Microgravity

NASA Astrophysics Data System (ADS)

Fedorov, Oleg

Ukrainian Program for Material Sciences in Microgravity O.P. Fedorov, Space Research Insti-tute of NASU -NSAU, Kyiv, The aim of the report is to present previous and current approach of Ukrainian research society to the prospect of material sciences in microgravity. This approach is based on analysis of Ukrainian program of research in microgravity, preparation of Russian -Ukrainian experiments on Russian segment of ISS and development of new Ukrainian strategy of space activity for the years 2010-2030. Two parts of issues are discussed: (i) the evolution of our views on the priorities in microgravity research (ii) current experiments under preparation and important ground-based results. item1 The concept of "space industrialization" and relevant efforts in Soviet and post -Soviet Ukrainian research institutions are reviewed. The main topics are: melt supercooling, crystal growing, testing of materials, electric welding and study of near-Earth environment. The anticipated and current results are compared. item 2. The main experiments in the framework of Ukrainian-Russian Research Program for Russian Segment of ISS are reviewed. Flight installations under development and ground-based results of the experiments on directional solidification, heat pipes, tribological testing, biocorrosion study is presented. Ground-based experiments and theoretical study of directional solidification of transparent alloys are reviewed as well as preparation of MORPHOS installation for study of succinonitrile -acetone in microgravity.

A 9700-hour durability test of a five centimeter diameter ion thruster

NASA Technical Reports Server (NTRS)

Nakanishi, S.; Finke, R. C.

1973-01-01

A modified Hughes SIT-5 thrustor has been life-tested at the Lewis Research Center. The final 2700 hours of the test are described with a charted history of thrustor operating parameters and off-normal events. Performance and operating characteristics were nearly constant throughout the test except for neutralizer heater power requirements and accelerator drain current. A post-shutdown inspection revealed sputter erosion of ion chamber components and component flaking of sputtered metal. Several flakes caused beamlet divergence and anomalous grid erosion, causing the test to be terminated. All sputter erosion sources have been identified and promising sputter resistant components are currently being evaluated.

Overview of Dynamic Test Techniques for Flight Dynamics Research at NASA LaRC (Invited)

NASA Technical Reports Server (NTRS)

Owens, D. Bruce; Brandon, Jay M.; Croom, Mark A.; Fremaux, C. Michael; Heim, Eugene H.; Vicroy, Dan D.

2006-01-01

An overview of dynamic test techniques used at NASA Langley Research Center on scale models to obtain a comprehensive flight dynamics characterization of aerospace vehicles is presented. Dynamic test techniques have been used at Langley Research Center since the 1920s. This paper will provide a partial overview of the current techniques available at Langley Research Center. The paper will discuss the dynamic scaling necessary to address the often hard-to-achieve similitude requirements for these techniques. Dynamic test techniques are categorized as captive, wind tunnel single degree-of-freedom and free-flying, and outside free-flying. The test facilities, technique specifications, data reduction, issues and future work are presented for each technique. The battery of tests conducted using the Blended Wing Body aircraft serves to illustrate how the techniques, when used together, are capable of characterizing the flight dynamics of a vehicle over a large range of critical flight conditions.

Battery development and testing at ESA

NASA Technical Reports Server (NTRS)

Verniolle, Jean

1987-01-01

The principal activities of the Energy Storage Section of the Space Research and Technology Center (ESTEC) of the European Space Agency are presented. Nickel-hydrogen and fuel cell systems development are reported. The European Space Battery Test Center (ESBTC) facilities are briefly described along with the current test programs and results obtained.

Adaptive Testing without IRT.

ERIC Educational Resources Information Center

Yan, Duanli; Lewis, Charles; Stocking, Martha

It is unrealistic to suppose that standard item response theory (IRT) models will be appropriate for all new and currently considered computer-based tests. In addition to developing new models, researchers will need to give some attention to the possibility of constructing and analyzing new tests without the aid of strong models. Computerized…

Critical Evaluation of Animal Alternative Tests for the Identification of Endocrine Active Substances

EPA Science Inventory

A significant amount of research is currently targeted to evaluate alternative test methods that may reduce, refine, or replace the use of animals, while ensuring human and environmental health and safety. It is important that the information gained from the alternative tests pr...

The Role of Evaluation and Plans for Evaluating the Current Testing Program.

ERIC Educational Resources Information Center

Winters, Lynn

The Palos Verdes Peninsula Unified School District Office of Program Evaluation and Research is responsible for providing information for program development and improvement; providing test information to special programs coordinators; and acting as a clearinghouse for all information concerning tests, evaluation methodology, and educational…

How Should Colleges Treat Multiple Admissions Test Scores? ACT Working Paper 2017-4

ERIC Educational Resources Information Center

Mattern, Krista; Radunzel, Justine; Bertling, Maria; Ho, Andrew

2017-01-01

The percentage of students retaking college admissions tests is rising (Harmston & Crouse, 2016). Researchers and college admissions offices currently use a variety of methods for summarizing these multiple scores. Testing companies, interested in validity evidence like correlations with college first-year grade-point averages (FYGPA), often…

Research Says…/High-Stakes Testing Narrows the Curriculum

ERIC Educational Resources Information Center

David, Jane L.

2011-01-01

The current rationale for standards-based reform goes like this: If standards are demanding and tests accurately measure achievement of those standards, then curriculum and instruction will become richer and more rigorous. By attaching serious consequences to schools that fail to increase test scores, U.S. policymakers believe that educators will…

Behavioral Toxicology in the 21st Century: Challenges and Opportunities for Behavioral Scientists

EPA Science Inventory

The National Research Council of the National Academies of Science recently published a report of its vision of toxicity testing in the 21st Century. The report proposes that the current toxicity testing paradigm that depends upon whole-animal tests be replaced with a strategy ba...

Cellular Sentinels Toxicity Platform

DTIC Science & Technology

2017-02-01

Air Force Research Laboratory 711th Human Performance Wing U.S. Air Force School of Aerospace Medicine Aeromedical Research Department 2510 Fifth St...toxicity testing is to assess the likely risks posed to human populations at ambient exposure levels. Unfortunately, current approaches to toxicology... human populations at ambient exposure levels. For the past 50 years, this goal has been met by high dose testing in experimental animals with

Determining Biology Student Teachers' Cognitive Structure on the Concept of "Diffusion" through the Free Word-Association Test and the Drawing-Writing Technique

ERIC Educational Resources Information Center

Kurt, Hakan; Ekici, Gülay; Aktas, Murat; Aksu, Özlem

2013-01-01

The aim of the current study is to investigate student biology teachers' cognitive structures related to "diffusion" through the free word-association test and the drawing-writing technique. As the research design of the study, the qualitative research method was applied. The data were collected from 44 student biology teachers. The free…

Blade Testing Trends (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Desmond, M.

2014-08-01

As an invited guest speaker, Michael Desmond presented on NREL's NWTC structural testing methods and capabilities at the 2014 Sandia Blade Workshop held on August 26-28, 2014 in Albuquerque, NM. Although dynamometer and field testing capabilities were mentioned, the presentation focused primarily on wind turbine blade testing, including descriptions and capabilities for accredited certification testing, historical methodology and technology deployment, and current research and development activities.

Japanese earthquake predictability experiment with multiple runs before and after the 2011 Tohoku-oki earthquake

NASA Astrophysics Data System (ADS)

Hirata, N.; Tsuruoka, H.; Yokoi, S.

2011-12-01

The current Japanese national earthquake prediction program emphasizes the importance of modeling as well as monitoring for a sound scientific development of earthquake prediction research. One major focus of the current program is to move toward creating testable earthquake forecast models. For this purpose, in 2009 we joined the Collaboratory for the Study of Earthquake Predictability (CSEP) and installed, through an international collaboration, the CSEP Testing Centre, an infrastructure to encourage researchers to develop testable models for Japan. We started Japanese earthquake predictability experiment on November 1, 2009. The experiment consists of 12 categories, with 4 testing classes with different time spans (1 day, 3 months, 1 year and 3 years) and 3 testing regions called 'All Japan,' 'Mainland,' and 'Kanto.' A total of 160 models, as of August 2013, were submitted, and are currently under the CSEP official suite of tests for evaluating the performance of forecasts. We will present results of prospective forecast and testing for periods before and after the 2011 Tohoku-oki earthquake. Because a seismic activity has changed dramatically since the 2011 event, performances of models have been affected very much. In addition, as there is the problem of authorized catalogue related to the completeness magnitude, most models did not pass the CSEP consistency tests. Also, we will discuss the retrospective earthquake forecast experiments for aftershocks of the 2011 Tohoku-oki earthquake. Our aim is to describe what has turned out to be the first occasion for setting up a research environment for rigorous earthquake forecasting in Japan.

Japanese earthquake predictability experiment with multiple runs before and after the 2011 Tohoku-oki earthquake

NASA Astrophysics Data System (ADS)

Hirata, N.; Tsuruoka, H.; Yokoi, S.

2013-12-01

The current Japanese national earthquake prediction program emphasizes the importance of modeling as well as monitoring for a sound scientific development of earthquake prediction research. One major focus of the current program is to move toward creating testable earthquake forecast models. For this purpose, in 2009 we joined the Collaboratory for the Study of Earthquake Predictability (CSEP) and installed, through an international collaboration, the CSEP Testing Centre, an infrastructure to encourage researchers to develop testable models for Japan. We started Japanese earthquake predictability experiment on November 1, 2009. The experiment consists of 12 categories, with 4 testing classes with different time spans (1 day, 3 months, 1 year and 3 years) and 3 testing regions called 'All Japan,' 'Mainland,' and 'Kanto.' A total of 160 models, as of August 2013, were submitted, and are currently under the CSEP official suite of tests for evaluating the performance of forecasts. We will present results of prospective forecast and testing for periods before and after the 2011 Tohoku-oki earthquake. Because a seismic activity has changed dramatically since the 2011 event, performances of models have been affected very much. In addition, as there is the problem of authorized catalogue related to the completeness magnitude, most models did not pass the CSEP consistency tests. Also, we will discuss the retrospective earthquake forecast experiments for aftershocks of the 2011 Tohoku-oki earthquake. Our aim is to describe what has turned out to be the first occasion for setting up a research environment for rigorous earthquake forecasting in Japan.

An Investigation of How the Channel of Input and Access to Test Questions Affect L2 Listening Test Performance

ERIC Educational Resources Information Center

Wagner, Elvis

2013-01-01

The use of video technology has become widespread in the teaching and testing of second-language (L2) listening, yet research into how this technology affects the learning and testing process has lagged. The current study investigated how the channel of input (audiovisual vs. audio-only) used on an L2 listening test affected test-taker…

Research Performed within the Non-Destructive Evaluation Team at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Burns, Erin A.

2004-01-01

Non-destructive testing is essential in many fields of manufacturing and research in order to perform reliable examination of potentially damaged materials and parts without destroying the inherent structure of the materials. Thus, the Non-Destructive Evaluation (NDE) Team at NASA Glenn Research Center partakes in various projects to improve materials testing equipment as well as analyze materials, material defects, and material deficiencies. Due to the array of projects within the NDE Team at this time, five research aims were supplemental to some current projects. A literature survey of "DE and testing methodologies as related to rocks was performed. Also, Mars Expedition Rover technology was assessed to understand the requirements for instrumentation in harsh space environments (e.g. temperature). Potential instrumentation and technologies were also considered and documented. The literature survey provided background and potential sources for a proposal to acquire funding for ultrasonic instrumentation on board a future Mars expedition. The laboratory uses a Santec Systems AcousticScope AS200 acoustography system. Labview code was written within the current program in order to improve the current performance of the acoustography system. A sample of Reinforced Carbon/Carbon (RCC) material from the leading edge of the space shuttle underwent various non-destructive tests (guided wave scanning, thermography, computed tomography, real time x-ray, etc.) in order to characterize its structure and examine possible defects. Guided wave scan data of a ceramic matrix composite (CMC) panel was reanalyzed utilizing image correlations and signal processing variables. Additional guided wave scans and thermography were also performed on the CMC panel. These reevaluated data and images will be used in future presentations and publications. An additional axis for the guided wave scanner was designed, constructed, and implemented. This additional axis allowed incremental spacing of the previously fixed transducers for ultrasonic velocity measurements.

Experiences, attitudes and barriers towards research amongst junior faculty of Pakistani medical universities.

PubMed

Sabzwari, Saniya; Kauser, Samreen; Khuwaja, Ali Khan

2009-11-16

The developing world has had limited quality research and in Pakistan, research is still in its infancy. We conducted a study to assess the proportion of junior faculty involved in research to highlight their attitude towards research, and identify the factors associated with their research involvement. A cross-sectional study was conducted in four medical universities/teaching hospitals in Pakistan, representing private and public sectors. A pre-tested, self-administered questionnaire was used to collect information from 176 junior faculty members of studied universities/hospitals. Logistic regression analysis was used to identify factors related to attitudes and barriers in research among those currently involved in research with those who were not. Overall, 41.5% of study subjects were currently involved in research. A highly significant factor associated with current research involvement was research training during the post-graduate period (p < 0.001). Other factors associated with current involvement in research were male gender, working in the public sector and previous involvement in research. Overall, a large majority (85.2%) of doctors considered research helpful in their profession and had a positive attitude towards research; nevertheless this positive attitude was more frequently reported by doctors who were currently involved in research compared to those who were not (OR = 4.69; 95% CI = 1.54-14.26). Similarly, a large proportion (83.5%) of doctors considered research difficult to conduct; higher by doctors who were not presently involved in research (OR = 2.74; 95% CI = 1.20-6.22) Less than half of the study participants were currently involved in research. Research output may improve if identified barriers are rectified. Further studies are recommended in this area.

Current and proposed practices for nondestructive highway pavement testing

DOT National Transportation Integrated Search

1997-11-01

In September 1994 the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) distributed a short survey on nondestructive testing practices to each of the 50 state Departments of Transportation (DOTs). The compilation of results constitut...

Application of empirical and mechanistic-empirical pavement design procedures to Mn/ROAD concrete pavement test sections

DOT National Transportation Integrated Search

1997-05-01

Current pavement design procedures are based principally on empirical approaches. The current trend toward developing more mechanistic-empirical type pavement design methods led Minnesota to develop the Minnesota Road Research Project (Mn/ROAD), a lo...

An Investigation on Computer-Adaptive Multistage Testing Panels for Multidimensional Assessment

ERIC Educational Resources Information Center

Wang, Xinrui

2013-01-01

The computer-adaptive multistage testing (ca-MST) has been developed as an alternative to computerized adaptive testing (CAT), and been increasingly adopted in large-scale assessments. Current research and practice only focus on ca-MST panels for credentialing purposes. The ca-MST test mode, therefore, is designed to gauge a single scale. The…

A Conversion of Wheatstone Bridge to Current-Loop Signal Conditioning for Strain Gages

NASA Technical Reports Server (NTRS)

Anderson, Karl F.

1995-01-01

Current loop circuitry replaced Wheatstone bridge circuitry to signal-condition strain gage transducers in more than 350 data channels for two different test programs at NASA Dryden Flight Research Center. The uncorrected test data from current loop circuitry had a lower noise level than data from comparable Wheatstone bridge circuitry, were linear with respect to gage-resistance change, and were uninfluenced by varying lead-wire resistance. The current loop channels were easier for the technicians to set up, verify, and operate than equivalent Wheatstone bridge channels. Design choices and circuit details are presented in this paper in addition to operational experience.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

PubMed

Gordon, Sarah; Daneshian, Mardas; Bouwstra, Joke; Caloni, Francesca; Constant, Samuel; Davies, Donna E; Dandekar, Gudrun; Guzman, Carlos A; Fabian, Eric; Haltner, Eleonore; Hartung, Thomas; Hasiwa, Nina; Hayden, Patrick; Kandarova, Helena; Khare, Sangeeta; Krug, Harald F; Kneuer, Carsten; Leist, Marcel; Lian, Guoping; Marx, Uwe; Metzger, Marco; Ott, Katharina; Prieto, Pilar; Roberts, Michael S; Roggen, Erwin L; Tralau, Tewes; van den Braak, Claudia; Walles, Heike; Lehr, Claus-Michael

2015-01-01

Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.

Research on trust-region algorithms for nonlinear programming. Final technical report, 1 January 1990--31 December 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dennis, J.E. Jr.; Tapia, R.A.

Goal of the research was to develop and test effective, robust algorithms for general nonlinear programming (NLP) problems, particularly large or otherwise expensive NLP problems. We discuss the research conducted over the 3-year period Jan. 1990-Dec. 1992. We also describe current and future directions of our research.

Experimental Results of Thin-Film Photovoltaic Cells in a Low Density LEO Plasma Environment: Ground Tests

NASA Technical Reports Server (NTRS)

Galofaro, Joel T.; Vayner, Boris V.

2006-01-01

Plasma ground testing results, conducted at the Glenn Research Center (GRC) National Plasma Interaction (N-PI) Facility, are presented for a number of thin-film photovoltaic cells. The cells represent a mix of promising new technologies identified by the Air Force Research Laboratory (AFRL) under the CYGNUS Space Science Technology Experiment (SSTE-4) Program. The current ground tests are aimed at characterizing the performance and survivability of thin film technologies in the harsh low earth orbital space environment where they will be flown. Measurements of parasitic current loss, charging/dielectric breakdown of cover-slide coatings and arcing threshold tests are performed for each individual cell. These measurements are followed by a series of experiments designed to test for catastrophic arc failure mechanisms. A special type of power supply, called a solar array simulator (SAS) with adjustable voltage and current limits on the supply s output, is employed to bias two adjacent cells at a predetermined voltage and current. The bias voltage is incrementally ramped up until a sustained arc results. Sustained arcs are precursors to catastrophic arc failure where the arc current rises to a maximum value for long timescales often ranging between 30 to 100 sec times. Normal arcs by comparison, are short lived events with a timescale between 10 to 30 sec. Sustained arcs lead to pyrolization with extreme cell damage and have been shown to cause the loss of entire array strings in solar arrays. The collected data will be used to evaluate the suitability of thin-film photovoltaic technologies for future space operations.

NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.

PubMed

Laughlin, Maren R; Lloyd, K C Kent; Cline, Gary W; Wasserman, David H

2012-10-01

The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and their complications. The intent is to allow researchers to take optimum advantage of the many new mouse models produced in labs and in high-throughput public efforts. The six MMPCs are located at universities around the country and perform complex metabolic tests in intact mice and hormone and analyte assays in tissues on a fee-for-service basis. Testing is subsidized by the NIH in order to reduce the barriers for mouse researchers. Although data derived from these tests belong to the researcher submitting mice or tissues, these data are archived after publication in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is hoped that data from experiments performed in many mouse models of metabolic diseases, using standard protocols, will be useful in understanding the nature of these complex disorders. The current areas of expertise include energy balance and body composition, insulin action and secretion, whole-body and tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and metabolic pathway kinetics. In addition to providing services, the MMPC staff provides expertise and advice to researchers, and works to develop and refine test protocols to best meet the community's needs in light of current scientific developments. Test technology is disseminated by publications and through annual courses.

Proposed Development of NASA Glenn Research Center's Aeronautical Network Research Simulator

NASA Technical Reports Server (NTRS)

Nguyen, Thanh C.; Kerczewski, Robert J.; Wargo, Chris A.; Kocin, Michael J.; Garcia, Manuel L.

2004-01-01

Accurate knowledge and understanding of data link traffic loads that will have an impact on the underlying communications infrastructure within the National Airspace System (NAS) is of paramount importance for planning, development and fielding of future airborne and ground-based communications systems. Attempting to better understand this impact, NASA Glenn Research Center (GRC), through its contractor Computer Networks & Software, Inc. (CNS, Inc.), has developed an emulation and test facility known as the Virtual Aircraft and Controller (VAC) to study data link interactions and the capacity of the NAS to support Controller Pilot Data Link Communications (CPDLC) traffic. The drawback of the current VAC test bed is that it does not allow the test personnel and researchers to present a real world RF environment to a complex airborne or ground system. Fortunately, the United States Air Force and Navy Avionics Test Commands, through its contractor ViaSat, Inc., have developed the Joint Communications Simulator (JCS) to provide communications band test and simulation capability for the RF spectrum through 18 GHz including Communications, Navigation, and Identification and Surveillance functions. In this paper, we are proposing the development of a new and robust test bed that will leverage on the existing NASA GRC's VAC and the Air Force and Navy Commands JCS systems capabilities and functionalities. The proposed NASA Glenn Research Center's Aeronautical Networks Research Simulator (ANRS) will combine current Air Traffic Control applications and physical RF stimulation into an integrated system capable of emulating data transmission behaviors including propagation delay, physical protocol delay, transmission failure and channel interference. The ANRS will provide a simulation/stimulation tool and test bed environment that allow the researcher to predict the performance of various aeronautical network protocol standards and their associated waveforms under varying density conditions. The system allows the user to define human-interactive and scripted aircraft and controller models of various standards, such as (but not limited to) Very High Frequency Digital Link (VDL) of various modes.

Modification to the Langley 8-foot high temperature tunnel for hypersonic propulsion testing

NASA Technical Reports Server (NTRS)

Reubush, D. E.; Puster, R. L.; Kelly, H. N.

1987-01-01

Described are the modifications currently under way to the Langley 8-Foot High Temperature Tunnel to produce a new, unique national resource for testing hypersonic air-breathing propulsion systems. The current tunnel, which has been used for aerothermal loads and structures research since its inception, is being modified with the addition of a LOX system to bring the oxygen content of the test medium up to that of air, the addition of alternate Mach number capability (4 and 5) to augment the current M=7 capability, improvements to the tunnel hardware to reduce maintenance downtime, the addition of a hydrogen system to allow the testing of hydrogen powered engines, and a new data system to increase both the quantity and quality of the data obtained.

U.S. Army Workshop on Solid-Propellant Ignition and Combustion Modeling.

DTIC Science & Technology

1997-07-01

saving tool in the design, development, testing, and evaluation of future gun-propulsion systems , and that, under current funding constraints, research...53 7.1 What systems are currently being addressed...9 ............. . . .. .. . . . . . . . . . . . . . . . . . . . . . . . . 56 7.5 What model systems might be valuable for

USING POTATOES IN PROPAGATION TESTS FOR NONTARGET PLANT EFFECTS

EPA Science Inventory

Current tests required for pesticide registration under the FIFRA only investigate seedling emergence and early growth. Previous research with sulfonylurea (SU) herbicides has shown that significant impacts can occur to plant reproduction with little or no visible effect on vege...

Treatment Options for Gastrointestinal Carcinoid Tumors

MedlinePlus

... have any of these signs or symptoms. Imaging studies and tests that examine the blood and urine are used ... or after starting their cancer treatment. Follow-up tests may be needed. ... is a research study meant to help improve current treatments or obtain ...

Stages of Gastrointestinal Carcinoid Tumors

MedlinePlus

... have any of these signs or symptoms. Imaging studies and tests that examine the blood and urine are used ... or after starting their cancer treatment. Follow-up tests may be needed. ... is a research study meant to help improve current treatments or obtain ...

Treatment Option Overview (Gastrointestinal Carcinoid Tumors)

MedlinePlus

... have any of these signs or symptoms. Imaging studies and tests that examine the blood and urine are used ... or after starting their cancer treatment. Follow-up tests may be needed. ... is a research study meant to help improve current treatments or obtain ...

A Report on the 2007 Outfield Variety Test

USDA-ARS?s Scientific Manuscript database

Outfield variety trials, the final testing stage in the Louisiana Variety Development Program, are evaluated cooperatively by the USDA Agricultural Research Service, Louisiana State University Agricultural Center, and American Sugar Cane League. Advanced experimental varieties as well as current co...

Center for Navy Business Excellence: A Catalyst for Business Transformation

DTIC Science & Technology

2005-12-01

selecting priority strategic initiatives and milestones. Key participants in the strategic planning process are Global Marketing and Sales Group...the Global Marketing Operations Group. This Group works to ensure current, best research practices are tested and utilized; establishing research

Easing Concerns About Returning Genetic Test Results

Cancer.gov

Women with breast cancer participating in a research study were given the opportunity to learn their genetic research results. This Cancer Currents blog details the impact these results had on women who opted to review their results with a genetic counselor.

Dust cyclone research in the 21st century

USDA-ARS?s Scientific Manuscript database

Research to meet the demand for ever more efficient dust cyclones continues after some eighty years. Recent trends emphasize design optimization through computational fluid dynamics (CFD) and testing design subtleties not modeled by semi-empirical equations. Improvements to current best available ...

Silicon Carbide Diodes Performance Characterization at High Temperatures

NASA Technical Reports Server (NTRS)

Lebron-Velilla, Ramon C.; Schwarze, Gene E.; Gardner, Brent G.; Adams, Jerry

2004-01-01

NASA Glenn Research center's Electrical Systems Development branch is working to demonstrate and test the advantages of Silicon Carbide (SiC) devices in actual power electronics applications. The first step in this pursuit is to obtain commercially available SiC Schottky diodes and to individually test them under both static and dynamic conditions, and then compare them with current state of the art silicon Schottky and ultra fast p-n diodes of similar voltage and current ratings. This presentation covers the results of electrical tests performed at NASA Glenn. Steady state forward and reverse current-volt (I-V) curves were generated for each device to compare performance and to measure their forward voltage drop at rated current, as well as the reverse leakage current at rated voltage. In addition, the devices were individually connected as freewheeling diodes in a Buck (step down) DC to DC converter to test their reverse recovery characteristics and compare their transient performance in a typical converter application. Both static and transient characterization tests were performed at temperatures ranging from 25 C to 300 C, in order to test and demonstrate the advantages of SiC over Silicon at high temperatures.

Study of the application of advanced technologies to long-range transport aircraft. Volume 2: Research and development requirements

NASA Technical Reports Server (NTRS)

Lange, R. H.; Sturgeon, R. F.; Adams, W. E.; Bradley, E. S.; Cahill, J. F.; Eudaily, R. R.; Hancock, J. P.; Moore, J. W.

1972-01-01

Investigations were conducted to evaluate the relative benefits attainable through the exploitation of advanced technologies and to identify future research and development efforts required to permit the application of selected technologies to transport aircraft entering commercial operation in 1985. Results show that technology advances, particularly in the areas of composite materials, supercritical aerodynamics, and active control systems, will permit the development of long-range, high-payload commercial transports operating at high-subsonic speeds with direct operating costs lower than those of current aircraft. These advanced transports also achieve lower noise levels and lower engine pollutant emissions than current transports. Research and development efforts, including analytical investigations, laboratory test programs, and flight test programs, are required in essentially all technology areas to achieve the potential technology benefits.

A summary of NASA/Air Force Full Scale Engine Research programs using the F100 engine

NASA Technical Reports Server (NTRS)

Deskin, W. J.; Hurrell, H. G.

1979-01-01

This paper summarizes a joint NASA/Air Force Full Scale Engine Research (FSER) program conducted with the F100 engine during the period 1974 through 1979. The program mechanism is described and the F100 test vehicles utilized are illustrated. Technology items which have been addressed in the areas of swirl augmentation, flutter phenomenon, advanced electronic control logic theory, strain gage technology, and distortion sensitivity are identified and the associated test programs conducted at the NASA-Lewis Research Center are described. Results presented show that the FSER approach, which utilizes existing state-of-the-art engine hardware to evaluate advanced technology concepts and problem areas, can contribute a significant data base for future system applications. Aerodynamic phenomenon previously not considered by current design systems have been identified and incorporated into current industry design tools.

National Toxicology Program: Review of current DHHS, DOE, and EPA research related to toxicology, Fiscal Year 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-06-01

The report represents responses by agencies of DHHS, and by DOE and EPA, to requests by the Director of NTP for information on agency programs in basic toxicology research, toxicology testing, and toxicology methods development. Information on dollar and manpower support for agency activities in basic toxicology research, toxicology testing, and toxicology methods development, by DHHS, DOE and EPA, is summarized on pages 4 to 10. All agencies were requested to provide summary information on their programs related to toxicology methods development, whether essential or peripheral to their missions. The information provided in response to the request is summarized inmore » tables on pages 48 to 81. Information was provided on chemical compounds currently being studied for their toxicological properties in intramural laboratories, or on contracts, or through grants.« less

Development and applications of nondestructive evaluation at Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Whitaker, Ann F.

1990-01-01

A brief description of facility design and equipment, facility usage, and typical investigations are presented for the following: Surface Inspection Facility; Advanced Computer Tomography Inspection Station (ACTIS); NDE Data Evaluation Facility; Thermographic Test Development Facility; Radiographic Test Facility; Realtime Radiographic Test Facility; Eddy Current Research Facility; Acoustic Emission Monitoring System; Advanced Ultrasonic Test Station (AUTS); Ultrasonic Test Facility; and Computer Controlled Scanning (CONSCAN) System.

"I Like to Read, but I Know I'm Not Good at It": Children's Perspectives on High-Stakes Testing in a High-Poverty School

ERIC Educational Resources Information Center

Dutro, Elizabeth; Selland, Makenzie

2012-01-01

A significant body of research articulates concerns about the current emphasis on high-stakes testing as the primary lever of education reform in the United States. However, relatively little research has focused on how children make sense of the assessment policies in which they are centrally located. In this article, we share analyses of…

Potential utilization of the NASA/George C. Marshall Space Flight Center in earthquake engineering research

NASA Technical Reports Server (NTRS)

Scholl, R. E. (Editor)

1979-01-01

Earthquake engineering research capabilities of the National Aeronautics and Space Administration (NASA) facilities at George C. Marshall Space Flight Center (MSFC), Alabama, were evaluated. The results indicate that the NASA/MSFC facilities and supporting capabilities offer unique opportunities for conducting earthquake engineering research. Specific features that are particularly attractive for large scale static and dynamic testing of natural and man-made structures include the following: large physical dimensions of buildings and test bays; high loading capacity; wide range and large number of test equipment and instrumentation devices; multichannel data acquisition and processing systems; technical expertise for conducting large-scale static and dynamic testing; sophisticated techniques for systems dynamics analysis, simulation, and control; and capability for managing large-size and technologically complex programs. Potential uses of the facilities for near and long term test programs to supplement current earthquake research activities are suggested.

Evaluation of surface resistivity measurements as an alternative to the rapid chloride permeability test for quality assurance and acceptance : LTRC research project capsule 10-1C.

DOT National Transportation Integrated Search

2010-02-01

Many entities currently use permeability specifications in Portland cement : concrete (PCC) pavements and structures. For those states using : permeability specifications, two test methods are generally used and include : ASTM C 1202 (Standard Test M...

Test-Retest Reliability of a Survey to Measure Transport-Related Physical Activity in Adults

ERIC Educational Resources Information Center

Badland, Hannah; Schofield, Grant

2006-01-01

The present research details test-retest reliability of a newly developed, telephone-administered TPA survey for adults. This instrument examines barriers, perceptions, and current travel behaviors to place of work/study and local convenience shops. Demonstrated test-retest reliability of the Active Friendly Environments-Transport-Related Physical…

Creating an Online Assessment Test for Heritage Learners of Russian

ERIC Educational Resources Information Center

Titus, Julia

2012-01-01

This paper examines the differences between second-language learners and heritage learners of Russian in terms of their linguistic performance, a finding supported by current research (Andrews, 2001; Kagan & Dillon, 2001/2003), examines the implications of these differences for the creation of testing tools, and offers a sample of a test designed…

Mission Information and Test Systems Summary of Accomplishments, 2012-2013

NASA Technical Reports Server (NTRS)

McMorrow, Sean; Sherrard, Roberta; Gibbs, Yvonne

2015-01-01

This annual report covers the activities of the NASA Dryden Flight Research Center's Mission Information and Test Systems directorate, which include the Western Aeronautical Test Range (Range Engineering and Range Operations), the Simulation Engineering Branch, and Information Services. This report contains highlights, current projects, and various awards achieved throughout 2012 and 2013.

Test Expectancy and Memory for Important Information

ERIC Educational Resources Information Center

Middlebrooks, Catherine D.; Murayama, Kou; Castel, Alan D.

2017-01-01

Prior research suggests that learners study and remember information differently depending upon the type of test they expect to later receive. The current experiments investigate how testing expectations impact the study of and memory for valuable information. Participants studied lists of words ranging in value from 1 to 10 points with the goal…

An Active-Learning Approach to Fostering Understanding of Research Methods in Large Classes

ERIC Educational Resources Information Center

LaCosse, Jennifer; Ainsworth, Sarah E.; Shepherd, Melissa A.; Ent, Michael; Klein, Kelly M.; Holland-Carter, Lauren A.; Moss, Justin H.; Licht, Mark; Licht, Barbara

2017-01-01

The current investigation tested the effectiveness of an online student research project designed to supplement traditional methods (e.g., lectures, discussions, and assigned readings) of teaching research methods in a large-enrollment Introduction to Psychology course. Over the course of the semester, students completed seven assignments, each…

Understanding the Relationship between Student Attitudes and Student Learning

ERIC Educational Resources Information Center

Cahill, Michael J.; McDaniel, Mark A.; Frey, Regina F.; Hynes, K. Mairin; Repice, Michelle; Zhao, Jiuqing; Trousil, Rebecca

2018-01-01

Student attitudes, defined as the extent to which one holds expertlike beliefs about and approaches to physics, are a major research topic in physics education research. An implicit but rarely tested assumption underlying much of this research is that student attitudes play a significant part in student learning and performance. The current study…

Experimental Supersonic Combustion Research at NASA Langley

NASA Technical Reports Server (NTRS)

Rogers, R. Clayton; Capriotti, Diego P.; Guy, R. Wayne

1998-01-01

Experimental supersonic combustion research related to hypersonic airbreathing propulsion has been actively underway at NASA Langley Research Center (LaRC) since the mid-1960's. This research involved experimental investigations of fuel injection, mixing, and combustion in supersonic flows and numerous tests of scramjet engine flowpaths in LaRC test facilities simulating flight from Mach 4 to 8. Out of this research effort has come scramjet combustor design methodologies, ground test techniques, and data analysis procedures. These technologies have progressed steadily in support of the National Aero-Space Plane (NASP) program and the current Hyper-X flight demonstration program. During NASP nearly 2500 tests of 15 scramjet engine models were conducted in LaRC facilities. In addition, research supporting the engine flowpath design investigated ways to enhance mixing, improve and apply nonintrusive diagnostics, and address facility operation. Tests of scramjet combustor operation at conditions simulating hypersonic flight at Mach numbers up to 17 also have been performed in an expansion tube pulse facility. This paper presents a review of the LaRC experimental supersonic combustion research efforts since the late 1980's, during the NASP program, and into the Hyper-X Program.

Materials Properties Research at MSFC

NASA Technical Reports Server (NTRS)

Presson, Joan B.; Burdine, Robert (Technical Monitor)

2002-01-01

MSFC is currently planning, organizing and directing test coupon fabrication and subsequent CTE testing for two mirror materials of specific interest to the AMSD and NGST programs, Beryllium 0-30H (Be 0-30H) and Ultra Low Expansion glass (ULE). The ULE test coupons are being fabricated at MSFC from AMSD core residuals provided by Kodak, The Be 0-30H test coupons are being fabricated at Brush Wellman using residuals from the SBMD. Both sets of test coupons will be sent to a test vendor selected through the NASA competitive proposal process with the test results being provided by written report to MSFC by the end of the fiscal year. The test results will become model input data for the AMSD analysts, both MSFC and contractor, providing an enhancement to the historical CTE data currently available.

A Heated Tube Facility for Rocket Coolant Channel Research

NASA Technical Reports Server (NTRS)

Green, James M.; Pease, Gary M.; Meyer, Michael L.

1995-01-01

The capabilities of a heated tube facility used for testing rocket engine coolant channels at the NASA Lewis Research Center are presented. The facility uses high current, low voltage power supplies to resistively heat a test section to outer wall temperatures as high as 730 C (1350 F). Liquid or gaseous nitrogen, gaseous helium, or combustible liquids can be used as the test section coolant. The test section is enclosed in a vacuum chamber to minimize heat loss to the surrounding system. Test section geometry, size, and material; coolant properties; and heating levels can be varied to generate heat transfer and coolant performance data bases.

Development of Independent-type Optical CT

NASA Astrophysics Data System (ADS)

Yamaguchi, Tatsushi; Shiozawa, Daigoro; Rokunohe, Toshiaki; Kida, Junzo; Zhang, Wei

Optical current transformers (optical CTs) have features that they can be made much smaller and lighter than conventional electromagnetic induction transformers by their simple structure, and contribute to improvement of equipment reliability because of their excellent surge resistance performance. Authors consider optical CTs to be next generation transformers, and are conducting research and development of optical CTs aiming to apply to measuring and protection in electric power systems. Specifically we developed an independent-type optical CT by utilizing basic data of optical CTs accumulated for large current characteristics, temperature characteristics, vibration resistance characteristics, and so on. In performance verification, type tests complying with IEC standards, such as short-time current tests, insulation tests, accuracy tests, and so on, showed good results. This report describes basic principle and configuration of optical CTs. After that, as basic characteristics of optical CTs, conditions and results of verification tests for dielectric breakdown characteristics of sensor fibers, large current characteristics, temperature characteristics, and vibration resistance characteristics are described. Finally, development outline of the independent-type optical CT aiming to apply to all digital substation and its type tests results are described.

Current State of Test Development, Administration, and Analysis: A Study of Faculty Practices.

PubMed

Bristol, Timothy J; Nelson, John W; Sherrill, Karin J; Wangerin, Virginia S

Developing valid and reliable test items is a critical skill for nursing faculty. This research analyzed the test item writing practice of 674 nursing faculty. Relationships between faculty characteristics and their test item writing practices were analyzed. Findings reveal variability in practice and a gap in implementation of evidence-based standards when developing and evaluating teacher-made examinations.

Students Perception on the Use of Computer Based Test

NASA Astrophysics Data System (ADS)

Nugroho, R. A.; Kusumawati, N. S.; Ambarwati, O. C.

2018-02-01

Teaching nowadays might use technology in order to disseminate science and knowledge. As part of teaching, the way evaluating study progress and result has also benefited from this IT rapid progress. The computer-based test (CBT) has been introduced to replace the more conventional Paper and Pencil Test (PPT). CBT are considered more advantageous than PPT. It is considered as more efficient, transparent, and has the ability of minimising fraud in cognitive evaluation. Current studies have indicated the debate of CBT vs PPT usage. Most of the current research compares the two methods without exploring the students’ perception about the test. This study will fill the gap in the literature by providing students’ perception on the two tests method. Survey approach is conducted to obtain the data. The sample is collected in two identical classes with similar subject in a public university in Indonesia. Mann-Whitney U test used to analyse the data. The result indicates that there is a significant difference between two groups of students regarding CBT usage. Student with different test method prefers to have test other than what they were having. Further discussion and research implication is discussed in the paper.

Upgrades, Current Capabilities and Near-Term Plans of the NASA ARC Mars Climate

NASA Technical Reports Server (NTRS)

Hollingsworth, J. L.; Kahre, Melinda April; Haberle, Robert M.; Schaeffer, James R.

2012-01-01

We describe and review recent upgrades to the ARC Mars climate modeling framework, in particular, with regards to physical parameterizations (i.e., testing, implementation, modularization and documentation); the current climate modeling capabilities; selected research topics regarding current/past climates; and then, our near-term plans related to the NASA ARC Mars general circulation modeling (GCM) project.

Investigation on microstructure and mechanical properties on pulsed current gas tungsten arc welded super alloy 617

NASA Astrophysics Data System (ADS)

Mageshkumar, K.; Kuppan, P.; Arivazhagan, N.

2017-11-01

The present research work investigates the metallurgical and mechanical properties of weld joint fabricated by alloy 617 by pulsed current gas tungsten arc welding (PCGTAW) technique. Welding was done by ERNiCrCoMo-1 filler wire. Optical and Scanning Electron Microscope (SEM) revealed the fine equiaxed dendritic in the fusion zone. Electron Dispersive Spectroscopy (EDS) demonstrates the presence of Mo-rich secondary phases in the grain boundary regions. Tensile test shows improved mechanical properties compared to the continuous current mode. Bend test didn’t indicate the presence of defects in the weldments.

Applying Adaptive Variables in Computerised Adaptive Testing

ERIC Educational Resources Information Center

Triantafillou, Evangelos; Georgiadou, Elissavet; Economides, Anastasios A.

2007-01-01

Current research in computerised adaptive testing (CAT) focuses on applications, in small and large scale, that address self assessment, training, employment, teacher professional development for schools, industry, military, assessment of non-cognitive skills, etc. Dynamic item generation tools and automated scoring of complex, constructed…

Development of Phased-Array Ultrasonic Testing Acceptability Criteria : (Phase I)

DOT National Transportation Integrated Search

2014-10-01

Phase I of this research effort involved a review of the current state of the art of weld inspection using PAUT, development of the preliminary technical approach to inspecting CJP butt welds with and without transitions, fabrication of suitable test...

The development of test beds to support the definition and evolution of the Space Station Freedom power system

NASA Technical Reports Server (NTRS)

Soeder, James F.; Frye, Robert J.; Phillips, Rudy L.

1991-01-01

Since the beginning of the Space Station Freedom Program (SSFP), the Lewis Research Center (LeRC) and the Rocketdyne Division of Rockwell International have had extensive efforts underway to develop test beds to support the definition of the detailed electrical power system design. Because of the extensive redirections that have taken place in the Space Station Freedom Program in the past several years, the test bed effort was forced to accommodate a large number of changes. A short history of these program changes and their impact on the LeRC test beds is presented to understand how the current test bed configuration has evolved. The current test objectives and the development approach for the current DC Test Bed are discussed. A description of the test bed configuration, along with its power and controller hardware and its software components, is presented. Next, the uses of the test bed during the mature design and verification phase of SSFP are examined. Finally, the uses of the test bed in operation and evolution of the SSF are addressed.

NASA Airframe Icing Research Overview Past and Current

NASA Technical Reports Server (NTRS)

Potapczuk, Mark

2009-01-01

This slide presentation reviews the past and current research that NASA has done in the area of airframe icing. Both the history experimental efforts and model development to understand the process and problem of ice formation are reviewed. This has resulted in the development of new experimental methods, advanced icing simulation software, flight dynamics and experimental databases that have an impact on design, testing, construction and certification and qualification of the aircraft and its sub-systems.

Investigation of Prognostic Ability of Novel Imaging Markers for Traumatic Brain Injury (TBI)

DTIC Science & Technology

2011-10-01

testing None of the above Psychological / Sociological ID: VIEW4514342955C00Name: Type of Research View: Lay Summary 1 * Provide a summary of the...best describe the current clinical status of the patient and which markers best predict a patient’s outcome status. ID: VIEW475E142D4E000Name: Lay ... Summary View: Justification, Objective, & Research Design 1 * Provide context, justification, and scientific/scholarly rationale for the study: Currently

A Flight Control System Architecture for the NASA AirSTAR Flight Test Infrastructure

NASA Technical Reports Server (NTRS)

Murch, Austin M.

2008-01-01

A flight control system architecture for the NASA AirSTAR infrastructure has been designed to address the challenges associated with safe and efficient flight testing of research control laws in adverse flight conditions. The AirSTAR flight control system provides a flexible framework that enables NASA Aviation Safety Program research objectives, and includes the ability to rapidly integrate and test research control laws, emulate component or sensor failures, inject automated control surface perturbations, and provide a baseline control law for comparison to research control laws and to increase operational efficiency. The current baseline control law uses an angle of attack command augmentation system for the pitch axis and simple stability augmentation for the roll and yaw axes.

When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment.

PubMed

Szucs, Denes; Ioannidis, John P A

2017-01-01

Null hypothesis significance testing (NHST) has several shortcomings that are likely contributing factors behind the widely debated replication crisis of (cognitive) neuroscience, psychology, and biomedical science in general. We review these shortcomings and suggest that, after sustained negative experience, NHST should no longer be the default, dominant statistical practice of all biomedical and psychological research. If theoretical predictions are weak we should not rely on all or nothing hypothesis tests. Different inferential methods may be most suitable for different types of research questions. Whenever researchers use NHST they should justify its use, and publish pre-study power calculations and effect sizes, including negative findings. Hypothesis-testing studies should be pre-registered and optimally raw data published. The current statistics lite educational approach for students that has sustained the widespread, spurious use of NHST should be phased out.

When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment

PubMed Central

Szucs, Denes; Ioannidis, John P. A.

2017-01-01

Null hypothesis significance testing (NHST) has several shortcomings that are likely contributing factors behind the widely debated replication crisis of (cognitive) neuroscience, psychology, and biomedical science in general. We review these shortcomings and suggest that, after sustained negative experience, NHST should no longer be the default, dominant statistical practice of all biomedical and psychological research. If theoretical predictions are weak we should not rely on all or nothing hypothesis tests. Different inferential methods may be most suitable for different types of research questions. Whenever researchers use NHST they should justify its use, and publish pre-study power calculations and effect sizes, including negative findings. Hypothesis-testing studies should be pre-registered and optimally raw data published. The current statistics lite educational approach for students that has sustained the widespread, spurious use of NHST should be phased out. PMID:28824397

Evaluation of candidate working fluid formulations for the electrothermal-chemical wind tunnel

NASA Technical Reports Server (NTRS)

Akyurtlu, Jale F.; Akyurtlu, Ates

1993-01-01

A new hypersonic test facility which can simulate conditions typical of atmospheric flight at Mach numbers up to 20 is currently under study at the NASA/LaRC Hypersonic Propulsion Branch. In the proposed research, it was suggested that a combustion augmented electrothermal wind tunnel concept may be applied to the planned hypersonic testing facility. The purpose of the current investigation is to evaluate some candidate working fluid formulations which may be used in the chemical-electrothermal wind. The efforts in the initial phase of this research were concentrated on acquiring the code used by GASL to model the electrothermal wind tunnel and testing it using the conditions of GASL simulation. The early version of the general chemical kinetics code (GCKP84) was obtained from NASA and the latest updated version of the code (LSENS) was obtained from the author Dr. Bittker. Both codes are installed on a personal computer with a 486 25 MHz processor and 16 Mbyte RAM. Since the available memory was not sufficient to debug LSENS, for the current work GCKP84 was used.

Research of aluminum alloys with using eddy-current transducers on the basis of cores of various form

NASA Astrophysics Data System (ADS)

Dmitriev, S. F.; Ishkov, A. V.; Katasonov, A. O.; Malikov, V. N.; Sagalakov, A. M.

2018-01-01

The research aims to develop a microminiature eddy current transducer for aluminum alloys. The research topic is considered relevant due to the need for evaluation and forecasting of safe operating life of aluminum. A microminiature transformer-type transducer was designed, which enables to perform local investigations of unferromagnetic materials using eddy-current method based on local studies conductivity. Having the designed transducer as a basis, a hardware-software complex was built to perform experimental studies of aluminium. Cores with different shapes were used in this work. Test results are reported for a flaws in the form of hidden slits and apertures inside the slabs is derived for excitation coil frequencies of 300-700 Hz.

Dispersant approval procedures in France and Italy: A comparative ecotoxicity study.

PubMed

Manfra, Loredana; Tornambè, Andrea; Guyomarch, Julien; Le Guerrogue, Pascale; Kerambrun, Loïc; Rotini, Alice; Savorelli, Federica; Onorati, Fulvio; Magaletti, Erika

2017-09-01

A research project has been performed to the request of the RAMOGE Executive Secretariat to identify differences between dispersant approval procedures in France and Italy and propose ways to harmonize them. A collaborative study has been conducted by CEDRE (Centre of Documentation, Research and Experimentation on Accidental Water Pollution) and ISPRA (Italian Institute for Environmental Protection and Research) to: a) compare current approval procedures in Italy and France with identification of differences and commonalities; b) carry out toxicity tests using both procedures on two selected dispersants; c) propose a common approach between Italy and France. The results showed that, because of the differences in ecotoxicological tests and in the evaluation criteria used, the outcomes on the same products could be different in Italy and in France. Both tested dispersants met the French requirements for approval (LC 50 ≥ 10 times reference toxicant), while only one dispersant met the Italian approval criterion (EC 50 > 10mg/L). A possible way of harmonizing the approval procedures could be to increase the number of test organisms in the French procedure, which currently only uses one crustacean species. Furthermore, a common criterion for toxicity assessment should be discussed and agreed. Copyright © 2017. Published by Elsevier Inc.

75 FR 29763 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-27

... commercialization of results of federally-funded research and development. Foreign patent applications are filed on... patent applications. Simple, Quantitative and Highly Specific Antibody Detection of Lyme Disease... markedly out-performed the C6 ELISA test (currently the most sensitive test available, with 76% sensitivity...

PapSEEK Test for Endometrial and Ovarian Cancer

Cancer.gov

Finding a way to detect endometrial and ovarian cancers early, when they are most likely to respond to treatment, has been a challenge for cancer researchers. An experimental liquid biopsy test called PapSEEK may help to change that, this Cancer Currents post explains.

Development of new test procedures for measuring fine and coarse aggregates specific gravity.

DOT National Transportation Integrated Search

2009-09-01

The objective of the research is to develop and evaluate new test methods at determining the specific gravity and absorption of both fine and coarse aggregates. Current methods at determining the specific gravity and absorption of fine and coarse agg...

Treatment Options for Childhood Extracranial Germ Cell Tumors

MedlinePlus

... menstrual periods . In females, unusual vaginal bleeding. Imaging studies and blood tests are used to detect (find) and diagnose childhood ... or after starting their cancer treatment. Follow-up tests may be needed. ... trial is a research study meant to help improve current treatments or obtain ...

Stages of Childhood Extracranial Germ Cell Tumors

MedlinePlus

... menstrual periods . In females, unusual vaginal bleeding. Imaging studies and blood tests are used to detect (find) and diagnose childhood ... or after starting their cancer treatment. Follow-up tests may be needed. ... trial is a research study meant to help improve current treatments or obtain ...

Childhood Central Nervous System Germ Cell Tumors Treatment

MedlinePlus

... very tired. Having problems with school work. Imaging studies and tests are used to detect (find) and diagnose childhood ... or after starting their cancer treatment. Follow-up tests may be needed. ... trial is a research study meant to help improve current treatments or obtain ...

Evaluating of NASA-Langley Research Center explosion seam welding

NASA Technical Reports Server (NTRS)

Otto, H. E.; Wittman, R.

1977-01-01

An explosion bonding technique to meet current fabrication requirements was demonstrated. A test program was conducted on explosion bonded joints, compared to fusion joints in 6061-T6 aluminum. The comparison was made in required fixtures, non-destructive testing, static strength and fatigue strength.

The development of test beds to support the definition and evolution of the Space Station Freedom power system

NASA Technical Reports Server (NTRS)

Soeder, James F.; Frye, Robert J.; Phillips, Rudy L.

1991-01-01

Since the beginning of the Space Station Freedom Program (SSFP), the NASA Lewis Research Center (LeRC) and the Rocketdyne Division of Rockwell International have had extensive efforts underway to develop testbeds to support the definition of the detailed electrical power system design. Because of the extensive redirections that have taken place in the Space Station Freedom Program in the past several years, the test bed effort was forced to accommodate a large number of changes. A short history of these program changes and their impact on the LeRC test beds is presented to understand how the current test bed configuration has evolved. The current test objectives and the development approach for the current DC test bed are discussed. A description of the test bed configuration, along with its power and controller hardware and its software components, is presented. Next, the uses of the test bed during the mature design and verification phase of SSFP are examined. Finally, the uses of the test bed in the operation and evolution of the SSF are addressed.

Base rate of performance invalidity among non-clinical undergraduate research participants.

PubMed

Silk-Eglit, Graham M; Stenclik, Jessica H; Gavett, Brandon E; Adams, Jason W; Lynch, Julie K; Mccaffrey, Robert J

2014-08-01

Neuropsychological research frequently uses non-clinical undergraduate participants to evaluate neuropsychological tests. However, a recent study by An and colleagues (2012, Archives of Clinical Neuropsychology, 27, 849-857) called into question that the extent to which the interpretation of these participants' performance on neuropsychological tests is valid. This study found that in a sample of 36 participants, 55.6% exhibited performance invalidity at an initial session and 30.8% exhibited performance invalidity at a follow-up session. The current study attempted to replicate these findings in a larger, more representative sample using a more rigorous methodology. Archival data from 133 non-clinical undergraduate research participants were analyzed. Participants were classified as performance invalid if they failed any one PVT. In the current sample, only 2.26% of participants exhibited performance invalidity. Thus, concerns regarding insufficient effort and performance invalidity when using undergraduate research participants appear to be overstated. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A Comparison of Validity Rates between Paper-and-Pencil and Computerized Testing with the MMPI-2

ERIC Educational Resources Information Center

Blazek, Nicole L.; Forbey, Johnathan D.

2011-01-01

Although the use of computerized testing in psychopathology assessment has increased in recent years, limited research has examined the impact of this format in terms of potential differences in test validity rates. The current study explores potential differences in the rates of valid and invalid Minnesota Multiphasic Personality Inventory--2…

A Study on the English Language Teachers' Preparation of Tests

ERIC Educational Resources Information Center

Saricoban, Arif

2011-01-01

In this article the researcher has examined the current situation in test (a) construction: designing, structuring, developing, (b) administering, and (c) assessing the foreign language tests to see if we are still at the same point (traditional) and has given some suggestions on this indispensable issue. To collect the necessary data the 4th year…

Severity of Organized Item Theft in Computerized Adaptive Testing: An Empirical Study. Research Report. ETS RR-06-22

ERIC Educational Resources Information Center

Yi, Qing; Zhang, Jinming; Chang, Hua-Hua

2006-01-01

Chang and Zhang (2002, 2003) proposed several baseline criteria for assessing the severity of possible test security violations for computerized tests with high-stakes outcomes. However, these criteria were obtained from theoretical derivations that assumed uniformly randomized item selection. The current study investigated potential damage caused…

Analyses of User Rationality and System Learnability: Performing Task Variants in User Tests

ERIC Educational Resources Information Center

Law, Effie Lai-Chong; Blazic, Borka Jerman; Pipan, Matic

2007-01-01

No systematic empirical study on investigating the effects of performing task variants on user cognitive strategy and behaviour in usability tests and on learnability of the system being tested has been documented in the literature. The current use-inspired basic research work aims to identify the underlying cognitive mechanisms and the practical…

Research and Practice on College English Oral Test--A Case Study of Beijing Institute of Petrochemical Technology

ERIC Educational Resources Information Center

Yan, Jiaolan; Zhang, Weiran; Yu, Yuan; Chang, Jie; Ding, Guangwei

2015-01-01

Based on the description of implementation of College English oral test from the points of the necessity, feasibility, and implementation process, this study analyzed the current situation of university students' oral English, oral English ability, the college entrance examination results, and a band-4 written test and established their…

Cosmopolitan Research and Public Thinking: Putting Oneself to the Test of Reality

ERIC Educational Resources Information Center

Hodgson, Naomi

2013-01-01

This paper returns to the theme of the academic turn to cosmopolitanism as a response to the challenges of globalisation, conflict, inequality and diversity discussed here previously. The discussion of cosmopolitanism here refers to the context of current policy relating to research and what it means to be a researcher in the European Union today…

A LTA flight research vehicle. [technology assessment, airships

NASA Technical Reports Server (NTRS)

Nebiker, F. R.

1975-01-01

An Airship Flight Research Program is proposed. Major program objectives are summarized and a Modernized Navy ZPG3W Airship recommended as the flight test vehicle. The origin of the current interest in modern airship vehicles is briefly discussed and the major benefits resulting from the flight research program described. Airship configurations and specifications are included.

Improving Comprehension of Capital Sentencing Instructions: Debunking Juror Misconceptions

ERIC Educational Resources Information Center

Otto, Charles W.; Applegate, Brandon K.; Davis, Robin King

2007-01-01

Previous research has demonstrated that judicial instructions on the law are not well understood by jurors tasked with applying the law to the facts of a case. The past research has also shown that jurors are often confused by the instructions used in the sentencing phase of a capital trial. The current research tested the effectiveness of a…

Analysis of space environment damage to solar cell assemblies from LDEF experiment A0171-GSFC test plate

NASA Technical Reports Server (NTRS)

Hill, David C.; Rose, M. Frank

1994-01-01

The results of the postflight analysis of the solar cell assemblies from the LDEF (Long Duration Exposure facility) experiment A0171 is provided in this NASA sponsored research project. The following data on this research are provided as follows: (1) solar cell description, including, substrate composition and thickness, crystal orientation, anti-reflective coating composition and thickness; (2) preflight characteristics of the solar cell assemblies with respect to current and voltage; and (3) post-flight characteristics of the solar cell assemblies with respect to voltage and current. These solar cell assemblies are part of the Goddard Space Flight Center test plate which was designed to test the space environment effects (radiation, atomic oxygen, thermal cycling, meteoroid and debris) on conductively coated solar cell coversheets, various electrical bond materials, solar cell performance, and other material properties where feasible.

A Statistical Procedure for Testing Unusually Frequent Exactly Matching Responses and Nearly Matching Responses. Research Report. ETS RR-17-23

ERIC Educational Resources Information Center

Haberman, Shelby J.; Lee, Yi-Hsuan

2017-01-01

In investigations of unusual testing behavior, a common question is whether a specific pattern of responses occurs unusually often within a group of examinees. In many current tests, modern communication techniques can permit quite large numbers of examinees to share keys, or common response patterns, to the entire test. To address this issue,…

Study of DC Circuit Breaker of H2-N2 Mixture Gas for High Voltage

NASA Astrophysics Data System (ADS)

Shiba, Yuji; Morishita, Yukinaga; Kaneko, Shuhei; Okabe, Shigemitsu; Mizoguchi, Hitoshi; Yanabu, Satoru

Global warming caused by CO2 etc. is a field where the concern is very high. Especially, automobile emissions are problem for it. Therefore, the hybrid car is widely development and used recently. Hybrid car used electric power and gasoline. So, the car reduces CO2. Hybrid car has engine and motor. To rotate the motor, hybrid car has battery. This battery is large capacity. Therefore, the relay should interrupt high DC current for the switch of the motor and the engine. So, hybrid car used hydrogen gas filling relay We studied interruption test for the research of a basic characteristic of hydrogen gas. DC current has not current zero point. So, it is necessary to make the current zero by high arc voltage and forcible current zero point. The loss coefficient and arc voltage of hydrogen is high. Therefore, we studied interruption test for used high arc voltage. We studied interruption test and dielectric breakdown test of air, pure Hydrogen, and Hydrogen- nitrogen mixture gas. As a result, we realized H2-N2(80%-20%) is the best gas.

Design of an expert-system flight status monitor

NASA Technical Reports Server (NTRS)

Regenie, V. A.; Duke, E. L.

1985-01-01

The modern advanced avionics in new high-performance aircraft strains the capability of current technology to safely monitor these systems for flight test prior to their generalized use. New techniques are needed to improve the ability of systems engineers to understand and analyze complex systems in the limited time available during crucial periods of the flight test. The Dryden Flight Research Facility of NASA's Ames Research Center is involved in the design and implementation of an expert system to provide expertise and knowledge to aid the flight systems engineer. The need for new techniques in monitoring flight systems and the conceptual design of an expert-system flight status monitor is discussed. The status of the current project and its goals are described.

The trials and tribulations of a practitioner-researcher: challenges and lessons learned through testing a feminist-cognitive-relational social work model of practice.

PubMed

Dombo, Eileen A; Bass, Ami P

2014-01-01

In practice with adult women who survived childhood sexual abuse, the field of social work currently lacks an evidence-based intervention. The current interventions, from the 1990s, come primarily from psychologists. The hypothesis that the Feminist-Cognitive-Relational Social Work Model and Intervention will be more effective in decreasing cognitive distortions, and increasing intimacy and relational health when compared to the standard agency intervention was tested in a quasi-experimental study. The challenges in carrying out the study in small, non-profit organizations are explored to highlight the difficulties in developing evidence-based interventions. Changes to implementation that resulted from the research findings are discussed.

Clinical perspective of cell-free DNA testing for fetal aneuploidies.

PubMed

Gratacós, Eduard; Nicolaides, Kypros

2014-01-01

Cell-free DNA testing in maternal blood provides the most effective method of screening for trisomy 21, with a reported detection rate of 99% and a false positive rate of less than 0.1%. After many years of research, this method is now commercially available and is carried out in an increasing number of patients, and there is an expanding number of conditions that can be screened for. However, the application of these methods in clinical practice requires a careful analysis. Current first-trimester screening strategies are based on a complex combination of tests, aiming at detecting fetal defects and predicting the risk of main pregnancy complications. It is therefore necessary to define the optimal way of combining cell-free DNA testing with current first-trimester screening methods. In this concise review we describe the basis of cell-free DNA testing and discuss the potential approaches for its implementation in combination with current tests in the first trimester. © 2014 S. Karger AG, Basel.

Advanced ice protection systems test in the NASA Lewis icing research tunnel

NASA Technical Reports Server (NTRS)

Bond, Thomas H.; Shin, Jaiwon; Mesander, Geert A.

1991-01-01

Tests of eight different deicing systems based on variations of three different technologies were conducted in the NASA Lewis Research Center Icing Research Tunnel (IRT) in June and July 1990. The systems used pneumatic, eddy current repulsive, and electro-expulsive means to shed ice. The tests were conducted on a 1.83 m span, 0.53 m chord NACA 0012 airfoil operated at a 4 degree angle of attack. The models were tested at two temperatures: a glaze condition at minus 3.9 C and a rime condition at minus 17.2 C. The systems were tested through a range of icing spray times and cycling rates. Characterization of the deicers was accomplished by monitoring power consumption, ice shed particle size, and residual ice. High speed video motion analysis was performed to quantify ice particle size.

Design and Testing of an Educational Water Tunnel

NASA Astrophysics Data System (ADS)

Kosaraju, Srinivas

2017-11-01

A new water tunnel is designed and tested for educational and research purposes at Northern Arizona University. The university currently owns an educational wind tunnel with a test section of 12in X 12in X 24in. However, due to limited size of test section and range of Reynolds numbers, its application is currently limited to very few experiments. In an effort to expand the educational and research capabilities, a student team is tasked to design, build and test a water tunnel as a Capstone Senior Design project. The water tunnel is designed to have a test section of 8in X 8in X 36in. and be able to test up to Re = 50E3. Multiple numerical models are used to optimize the flow field inside the test section before building the physical apparatus. The water tunnel is designed to accommodate multiple experiments for drag and lift studies. The built-in die system can deliver up to three different colors to study the streamlines and vortex shedding from the surfaces. During the first phase, a low discharge pump is used to achieve Re = 4E3 to test laminar flows. In the second phase, a high discharge pump will be used to achieve targeted Re = 50E3 to study turbulent flows.

Space Power Facility-Capabilities for Space Environmental Testing Within a Single Facility

NASA Technical Reports Server (NTRS)

Sorge, Richard N.

2013-01-01

The purpose of this paper is to describe the current and near-term environmental test capabilities of the NASA Glenn Research Center's Space Power Facility (SPF) located at Sandusky, Ohio. The paper will present current and near-term capabilities for conducting electromagnetic interference and compatibility testing, base-shake sinusoidal vibration testing, reverberant acoustic testing, and thermal-vacuum testing. The paper will also present modes of transportation, handling, ambient environments, and operations within the facility to conduct those tests. The SPF is in the midst of completing and activating new or refurbished capabilities which, when completed, will provide the ability to conduct most or all required full-scale end-assembly space simulation tests at a single test location. It is envisioned that the capabilities will allow a customer to perform a wide range of space simulation tests in one facility at reasonable cost.

The State of Retrieval System Evaluation.

ERIC Educational Resources Information Center

Salton, Gerald

1992-01-01

The current state of information retrieval (IR) evaluation is reviewed with criticisms directed at the available test collections and the research and evaluation methodologies used, including precision and recall rates for online searches and laboratory tests not including real users. Automatic text retrieval systems are also discussed. (32…

Immunotoxicity testing: Implementation of mechanistic understanding, key pathways of toxicological concern and components of these pathways.

EPA Science Inventory

At present, several animal-based assays are used to assess immunotoxic effects such as immunosuppression and sensitization. Growing societal and ethical concerns, European legislation and current research demands by industry are driving animal-based toxicity testing towards new a...

Teachers Negotiating Professional Agency through Literature-Based Assessment

ERIC Educational Resources Information Center

Simpson, Alyson

2017-01-01

Research reports teachers around the world currently face major challenges to their professional agency. They face numerous pressures from accountability measures operating in the highly politicised field of literacy education and standardised testing. At the same time international research encourages teachers to design rich assessment tasks…

Gas electron multiplier (GEM) foil test, repair and effective gain calculation

NASA Astrophysics Data System (ADS)

Tahir, Muhammad; Zubair, Muhammad; Khan, Tufail A.; Khan, Ashfaq; Malook, Asad

2018-06-01

The focus of my research is based on the gas electron multiplier (GEM) foil test, repairing and effective gain calculation of GEM detector. During my research work define procedure of GEM foil testing short-circuit, detection short-circuits in the foil. Study different ways to remove the short circuits in the foils. Set and define the GEM foil testing procedures in the open air, and with nitrogen gas. Measure the leakage current of the foil and applying different voltages with specified step size. Define the Quality Control (QC) tests and different components of GEM detectors before assembly. Calculate the effective gain of GEM detectors using 109Cd and 55Fe radioactive source.

UTM Weather Presentation

NASA Technical Reports Server (NTRS)

Chan, William N.; Kopardekar, Parimal H.; Carmichael, Bruce; Cornman, Larry

2017-01-01

Presentation highlighting how weather affected UAS operations during the UTM field tests. Research to develop UAS weather translation models with a description of current and future work for UTM weather.

Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment.

PubMed

Maxwell, Gavin; Aeby, Pierre; Ashikaga, Takao; Bessou-Touya, Sandrine; Diembeck, Walter; Gerberick, Frank; Kern, Petra; Marrec-Fairley, Monique; Ovigne, Jean-Marc; Sakaguchi, Hitoshi; Schroeder, Klaus; Tailhardat, Magali; Teissier, Silvia; Winkler, Petra

2011-01-01

Allergic contact dermatitis is a delayed-type hypersensitivity reaction induced by small reactive chemicals (haptens). Currently, the sensitising potential and potency of new chemicals is usually characterised using data generated via animal studies, such as the local lymph node assay (LLNA). There are, however, increasing public and political concerns regarding the use of animals for the testing of new chemicals. Consequently, the development of in vitro, in chemico or in silico models for predicting the sensitising potential and/or potency of new chemicals is receiving widespread interest. The Colipa Skin Tolerance task force currently collaborates with and/or funds several academic research groups to expand our understanding of the molecular and cellular events occurring during the acquisition of skin sensitisation. Knowledge gained from this research is being used to support the development and evaluation of novel alternative approaches for the identification and characterisation of skin sensitizing chemicals. At present three non-animal test methods (Direct Peptide Reactivity Assay (DPRA), Myeloid U937 Skin Sensitisation Test (MUSST) and human Cell Line Activation Test (hCLAT)) have been evaluated in Colipa interlaboratory ring trials for their potential to predict skin sensitisation potential and were recently submitted to ECVAM for formal pre-validation. Data from all three test methods will now be used to support the study and development of testing strategy approaches for skin sensitiser potency prediction. This publication represents the current viewpoint of the cosmetics industry on the feasibility of replacing the need for animal test data for informing skin sensitisation risk assessment decisions.

U-Mo Monolithic Fuel for Nuclear Research and Test Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prabhakaran, Ramprashad

The metallic fuel selected to replace the current HEU fuels in the research and test reactors is the LEU-10 weight % Mo alloy in the form of a thin sheet or foil encapsulated in AA6061 aluminum alloy with a zirconium interlayer. In order to effectively lead this pursuit, new developments in processing and fabrication of the fuel elements have been initiated, along with a better understanding of material behavior before and after irradiation as a result of these new developments. This editorial note gives an introduction about research and test reactors, need for HEU to LEU conversion, fuel requirements, highmore » uranium density monolithic fuel development and an overview of the four articles published in the December 2017 issue of JOM under a special topic titled “U-Mo Monolithic Fuel for Nuclear Research and Test Reactors”.« less

Current Effects of Army Materiel Command Operation Order 16 189 at TACOM LCMC

DTIC Science & Technology

2017-05-25

Alexandria, VA: CNA Corporation. 78 Creswell, J. W. (2015). Educational Research: Planning, Conducting, and Evaluating Quantitative and Qualitative...research and development that relate to military requirements and test and evaluation . (d)(3) The Secretary shall establish or designate a single office or...for research. 4. Collect data. 5. Analyze and interpret the data. 42 6. Report and evaluate the research. Step 4 of the research process is

P11, A Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress

DTIC Science & Technology

2014-10-01

experiments based on the proposed research design . We tested memory retrieval performance with wild type and p11 knockout mice, which developed and...not different on the final day of training or probe test . We also found that corticosterone resulted in significant decreases in the time spent in...mechanism of underlying memory and p11 in stress and fill a knowledge gap in the current research on PTSD. Such knowledge may facilitate the

Update of the U.S. Army Research Institute’s Longitudinal Research Data Base of Enlisted Personnel

DTIC Science & Technology

1992-08-01

accession data elements, including Composite score data from the Army Classification Battery Test (ACB), were captured for each individual. For each...individual, Skill Qualifying Test (SQT) scores were included beginning in 1980 and additional data were included from the Enlisted Master File (EMF). The...entry into active duty for current tour, pay grade, Composite and SQT scores , and military occupation specialty (MOS). The EPRDB is designed to play an

Fatigue Test Design: Scenarios for Biaxial Fatigue Testing of a 60-Meter Wind Turbine Blade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Post, Nathan

Current practice in commercial certification of wind turbine blades is to perform separate flap and lead-lag fatigue tests. The National Renewable Energy Laboratory has been researching and evaluating biaxial fatigue testing techniques and demonstrating various options, typically on smaller-scale test articles at the National Wind Technology Center. This report evaluates some of these biaxial fatigue options in the context of application to a multimegawatt blade certification test program at the Wind Technology Testing Center in Charlestown, Massachusetts.

Irradiation Tests Supporting LEU Conversion of Very High Power Research Reactors in the US

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woolstenhulme, N. E.; Cole, J. I.; Glagolenko, I.

The US fuel development team is developing a high density uranium-molybdenum alloy monolithic fuel to enable conversion of five high-power research reactors. Previous irradiation tests have demonstrated promising behavior for this fuel design. A series of future irradiation tests will enable selection of final fuel fabrication process and provide data to qualify the fuel at moderately-high power conditions for use in three of these five reactors. The remaining two reactors, namely the Advanced Test Reactor and High Flux Isotope Reactor, require additional irradiation tests to develop and demonstrate the fuel’s performance with even higher power conditions, complex design features, andmore » other unique conditions. This paper reviews the program’s current irradiation testing plans for these moderately-high irradiation conditions and presents conceptual testing strategies to illustrate how subsequent irradiation tests will build upon this initial data package to enable conversion of these two very-high power research reactors.« less

Critical Review of the ECSS-E-ST-20-07C ESD Test Set-Up for Testing Spacecraft Equipment

NASA Astrophysics Data System (ADS)

Pelissou, P.; Daout, B.; Romero, C.; Wolf, K.-F. J.

2016-05-01

Satellite equipment needs to be immune to electrostatic discharges (ESD) likely to occur in flight. Testing the susceptibility against ESD on spacecraft equipment is therefore an important part of the EMC test program. The test method according to ECSS-E-ST- 20-07C [1], which is commonly used in space industry, leaves undesirable degrees of freedom on how the test is performed, which in turn has an influence on the injected current and therefore on the test results. Because of the indirect coupling of ESD to circuits, the current waveform applied during the test and its repeatability are of high importance. In the frame of an ESTEC research contract (4000109887/13/NL/GLC), a critical review of the ECSS-E-ST-20-07C is performed to identify the influence factors which have an impact on the test repeatability.

Animal behavioral assessments in current research of Parkinson's disease.

PubMed

Asakawa, Tetsuya; Fang, Huan; Sugiyama, Kenji; Nozaki, Takao; Hong, Zhen; Yang, Yilin; Hua, Fei; Ding, Guanghong; Chao, Dongman; Fenoy, Albert J; Villarreal, Sebastian J; Onoe, Hirotaka; Suzuki, Katsuaki; Mori, Norio; Namba, Hiroki; Xia, Ying

2016-06-01

Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research. Copyright © 2016 Elsevier Ltd. All rights reserved.

Current Activities of the Joint Council on Economic Education.

ERIC Educational Resources Information Center

Highsmith, Robert J.

1987-01-01

Reviews current activities of the Joint Council, among them, a researcher training institute, a new K-12 economic education scope and sequence document, a junior high level test of economic knowledge, an instructional package for advanced placement classes, a textbook conference, a project to help teachers of students who work with at-risk…

Operating capability and current status of the reactivated NASA Lewis Research Center Hypersonic Tunnel Facility

NASA Technical Reports Server (NTRS)

Thomas, Scott R.; Trefny, Charles J.; Pack, William D.

1995-01-01

The NASA Lewis Research Center's Hypersonic Tunnel Facility (HTF) is a free-jet, blowdown propulsion test facility that can simulate up to Mach-7 flight conditions with true air composition. Mach-5, -6, and -7 nozzles, each with a 42 inch exit diameter, are available. Previously obtained calibration data indicate that the test flow uniformity of the HTF is good. The facility, without modifications, can accommodate models approximately 10 feet long. The test gas is heated using a graphite core induction heater that generates a nonvitiated flow. The combination of clean-air, large-scale, and Mach-7 capabilities is unique to the HTF and enables an accurate propulsion performance determination. The reactivation of the HTF, in progress since 1990, includes refurbishing the graphite heater, the steam generation plant, the gaseous oxygen system, and all control systems. All systems were checked out and recertified, and environmental systems were upgraded to meet current standards. The data systems were also upgraded to current standards and a communication link with NASA-wide computers was added. In May 1994, the reactivation was complete, and an integrated systems test was conducted to verify facility operability. This paper describes the reactivation, the facility status, the operating capabilities, and specific applications of the HTF.

Large transient fault current test of an electrical roll ring

NASA Technical Reports Server (NTRS)

Yenni, Edward J.; Birchenough, Arthur G.

1992-01-01

The space station uses precision rotary gimbals to provide for sun tracking of its photoelectric arrays. Electrical power, command signals and data are transferred across the gimbals by roll rings. Roll rings have been shown to be capable of highly efficient electrical transmission and long life, through tests conducted at the NASA Lewis Research Center and Honeywell's Satellite and Space Systems Division in Phoenix, AZ. Large potential fault currents inherent to the power system's DC distribution architecture, have brought about the need to evaluate the effects of large transient fault currents on roll rings. A test recently conducted at Lewis subjected a roll ring to a simulated worst case space station electrical fault. The system model used to obtain the fault profile is described, along with details of the reduced order circuit that was used to simulate the fault. Test results comparing roll ring performance before and after the fault are also presented.

An Overview of Models of Speaking Performance and Its Implications for the Development of Procedural Framework for Diagnostic Speaking Tests

ERIC Educational Resources Information Center

Zhao, Zhongbao

2013-01-01

This paper aims at developing a procedural framework for the development and validation of diagnostic speaking tests. The researcher reviews the current available models of speaking performance, analyzes the distinctive features and then points out the implications for the development of a procedural framework for diagnostic speaking tests. On…

Monitoring the Impact of Testing and Evaluation Innovations Project: State Activity and Interest Concerning Performance-Based Assessment.

ERIC Educational Resources Information Center

Center for Research on Evaluation, Standards, and Student Testing, Los Angeles, CA.

Information was gathered about current state interest, activity, and concerns related to performance assessment for students. The Center for Research on Evaluation, Standards, and Student Testing of the University of California (Los Angeles) conducted telephone interviews with directors of testing in each of the 50 states in the spring of 1990.…

How Does the Linguistic Distance between Spoken and Standard Language in Arabic Affect Recall and Recognition Performances during Verbal Memory Examination

ERIC Educational Resources Information Center

Taha, Haitham

2017-01-01

The current research examined how Arabic diglossia affects verbal learning memory. Thirty native Arab college students were tested using auditory verbal memory test that was adapted according to the Rey Auditory Verbal Learning Test and developed in three versions: Pure spoken language version (SL), pure standard language version (SA), and…

Models for Scoring Missing Responses to Multiple-Choice Items. Program Statistics Research Technical Report No. 94-1.

ERIC Educational Resources Information Center

Longford, Nicholas T.

This study is a critical evaluation of the roles for coding and scoring of missing responses to multiple-choice items in educational tests. The focus is on tests in which the test-takers have little or no motivation; in such tests omitting and not reaching (as classified by the currently adopted operational rules) is quite frequent. Data from the…

Elementary Teachers' Knowledge and Self-Efficacy for Measurement Concepts

ERIC Educational Resources Information Center

Gotch, Chad M.; French, Brian F.

2013-01-01

Educational standardized testing impacts millions of children and educational professionals each year. In the current accountability climate, an effective educational system depends on professionals who are literate in assessment and can take the appropriate actions in response to test results. Measurement researchers should begin to focus more…

Critical Evaluation of Animal Alternative Tests for the Identification of Endocrine Active Substances, oral presentation

EPA Science Inventory

In the past 20 years, considerable progress in animal alternatives accompanied by advances in the toxicological sciences and new emphases on aquatic vertebrates has appeared. A significant amount of current research is targeted to evaluate alternative test methods that may reduce...

Field test on the treatment of source zone chloroethenes using emulsified zerovalent iron

EPA Science Inventory

This talk summarizes the research activities currently underway at the Solid Waste Management Unit 45 (Site 45), Marine Corps Recruit Depot, Parris Island, South Carolina. A pilot field test was initiated in 2005 at this site to evaluate the effectiveness of nanoscale emulsified...

Some Current Problems in Simulator Design, Testing and Use.

ERIC Educational Resources Information Center

Caro, Paul W.

Concerned with the general problem of the effectiveness of simulator training, this report reflects information developed during the conduct of aircraft simulator training research projects sponsored by the Air Force, Army, Navy, and Coast Guard. Problems are identified related to simulator design, testing, and use, all of which impact upon…

QUEST/Ada (Query Utility Environment for Software Testing of Ada): The development of a prgram analysis environment for Ada, task 1, phase 2

NASA Technical Reports Server (NTRS)

Brown, David B.

1990-01-01

The results of research and development efforts are described for Task one, Phase two of a general project entitled The Development of a Program Analysis Environment for Ada. The scope of this task includes the design and development of a prototype system for testing Ada software modules at the unit level. The system is called Query Utility Environment for Software Testing of Ada (QUEST/Ada). The prototype for condition coverage provides a platform that implements expert system interaction with program testing. The expert system can modify data in the instrument source code in order to achieve coverage goals. Given this initial prototype, it is possible to evaluate the rule base in order to develop improved rules for test case generation. The goals of Phase two are the following: (1) to continue to develop and improve the current user interface to support the other goals of this research effort (i.e., those related to improved testing efficiency and increased code reliable); (2) to develop and empirically evaluate a succession of alternative rule bases for the test case generator such that the expert system achieves coverage in a more efficient manner; and (3) to extend the concepts of the current test environment to address the issues of Ada concurrency.

Stakeholder Assessment of the Evidence for Cancer Genomic Tests: Insights from Three Case Studies

PubMed Central

Deverka, Patricia A.; Schully, Sheri D.; Ishibe, Naoko; Carlson, Josh J.; Freedman, Andrew; Goddard, Katrina A.B.; Khoury, Muin J.; Ramsey, Scott D.

2015-01-01

Insufficient evidence on the net benefits and harms of genomic tests in real-world settings is a translational barrier for genomic medicine. Purpose Understanding stakeholders’ assessment of the current evidence base for clinical practice and coverage decisions should be a critical step to influence research, policy, and practice. Methods Twenty-two stakeholders participated in a workshop exploring the evidence of genomic tests for clinical and coverage decision-making. Stakeholders completed a survey prior to and during the meeting. They also discussed if they would recommend for or against current clinical use of each test. Results At baseline, the level of confidence on the clinical validity and clinical utility of each test varied, although the group expressed greater confidence for EGFR mutation and Lynch Syndrome (LS) testing than for Oncotype DX. Following the discussion, survey results reflected even less confidence for Oncotype DX and EGFR testing, but not LS. The majority of stakeholders would consider clinical use for all three tests, but under the conditions of additional research or a shared clinical decision-making approach. Conclusion Stakeholder engagement in unbiased settings is necessary to understand various perspectives about evidentiary thresholds in genomic medicine. Participants recommended the use of various methods for evidence generation and synthesis. PMID:22481130

European Union and Greek Lifelong Learning Policy within an Intercultural Context: Preliminary Insights from Research in the Sociology of Law

ERIC Educational Resources Information Center

Koutidou, Evangelia

2014-01-01

This paper presents preliminary findings of an extensive socio-legal research project, currently in progress, concerning the implementation of the European Union and the Greek institutional framework on lifelong learning (LLL) and exploring the social effectiveness of LLL policy. The main outcomes, based on testing two research hypotheses through…

Psychometric Assessment and Reporting Practices: Incongruence between Theory and Practice

ERIC Educational Resources Information Center

Slaney, Kathleen L.; Tkatchouk, Masha; Gabriel, Stephanie M.; Maraun, Michael D.

2009-01-01

The aim of the current study is twofold: (a) to investigate the rates at which researchers assess and report on the psychometric properties of the measures they use in their research and (b) to examine whether or not researchers appear to be generally employing sound/unsound rationales when it comes to how they conduct test evaluations. Based on a…

NASA Dryden Flight Research Center C-17 Research Overview

NASA Technical Reports Server (NTRS)

Miller, Chris

2007-01-01

A general overview of NASA Dryden Flight Research Center's C-17 Aircraft is presented. The topics include: 1) 2006 Activities PHM Instrumentation Refurbishment; 2) Acoustic and Vibration Sensors; 3) Gas Path Sensors; 4) NASA Instrumentation System Racks; 5) NASA C-17 Simulator; 6) Current Activities; 7) Future Work; 8) Lawn Dart ; 9) Weight Tub; and 10) Parachute Test Vehicle.

Psychological Issues in Cancer Genetics: Current Research and Future Priorities.

ERIC Educational Resources Information Center

Hopwood, Penelope

1997-01-01

Data concerning the psychological impact of high risk of cancer are reviewed, including implications of genetic testing, breast screening,and accuracy of women's risk estimates. Work in progress on prophylactic mastectomy and chemoprevention is reviewed. Research on cancer families, and interventions and prevention strategies for high-risk…

77 FR 19678 - Cooperative Research and Development Agreement: Asset Tracking and Reporting Technology

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... Cooperative Research and Development Agreement (CRADA) with General Dynamics C4 Systems, Inc. (General Dynamics), to test, evaluate, and document the strengths and weaknesses of at least one technical approach... Guard is currently considering partnering with General Dynamics, we are soliciting public comment on the...

Integrating Data-Based Decision Making, Assessment for Learning and Diagnostic Testing in Formative Assessment

ERIC Educational Resources Information Center

Van der Kleij, Fabienne M.; Vermeulen, Jorine A.; Schildkamp, Kim; Eggen, Theo J. H .M.

2015-01-01

Recent research has highlighted the lack of a uniform definition of formative assessment, although its effectiveness is widely acknowledged. This paper addresses the theoretical differences and similarities amongst three approaches to formative assessment that are currently most frequently discussed in educational research literature: data-based…

The Development of Technological Competence from Adolescence to Adulthood

ERIC Educational Resources Information Center

Autio, Ossi

2011-01-01

This article builds on earlier research that defined and assessed technological competence among adolescents. It tracks students who took part in a measurements of technical abilities study fifteen years ago. The researcher had no previous knowledge of the test subjects' current employment status, but in favorable circumstances, these test…

Testing for Blackleg and Dickeya in the 2017 field season

USDA-ARS?s Scientific Manuscript database

This article is aimed at raising awareness of the recently emerged potato blackleg disease and the research being conducted at USDA-ARS Ithaca and Cornell University to address this problem. This article explains the current management strategies for this disease and explains our research team’s re...

New Assessments, New Rigor

ERIC Educational Resources Information Center

Joan Herman; Robert Linn

2014-01-01

Researching. Synthesizing. Reasoning with evidence. The PARCC and Smarter Balanced assessments are clearly setting their sights on complex thinking skills. Researchers Joan Herman and Robert Linn look at the new assessments to see how they stack up against Norman Webb's depth of knowledge framework as well as against current state tests. The…

Current Research and Potential Applications of the Concealed Information Test: An Overview

PubMed Central

Ben-Shakhar, Gershon

2012-01-01

Research interest in psychophysiological detection of deception has significantly increased since the September 11 terror attack in the USA. In particular, the concealed information test (CIT), designed to detect memory traces that can connect suspects to a certain crime, has been extensively studied. In this paper I will briefly review several psychophysiological detection paradigms that have been studied, with a focus on the CIT. The theoretical background of the CIT, its strength and weaknesses, its potential applications as well as research finings related to its validity (based on a recent meta-analytic study), will be discussed. Several novel research directions, with a focus on factors that may affect CIT detection in realistic settings (e.g., memory for crime details; the effect of emotional stress during crime execution) will be described. Additionally, research focusing on mal-intentions and attempts to detect terror networks using information gathered from groups of suspects using both the standard CIT and the searching CIT will be reviewed. Finally, implications of current research to the actual application of the CIT will be discussed and several recommendations that can enhance the use of the CIT will be made. PMID:23060826

Drones for aerodynamic and structural testing /DAST/ - A status report

NASA Technical Reports Server (NTRS)

Murrow, H. N.; Eckstrom, C. V.

1978-01-01

A program for providing research data on aerodynamic loads and active control systems on wings with supercritical airfoils in the transonic speed range is described. Analytical development, wind tunnel tests, and flight tests are included. A Firebee II target drone vehicle has been modified for use as a flight test facility. The program currently includes flight experiments on two aeroelastic research wings. The primary purpose of the first flight experiment is to demonstrate an active control system for flutter suppression on a transport-type wing. Design and fabrication of the wing are complete and after installing research instrumentation and the flutter suppression system, flight testing is expected to begin in early 1979. The experiment on the second research wing - a fuel-conservative transport type - is to demonstrate multiple active control systems including flutter suppression, maneuver load alleviation, gust load alleviation, and reduce static stability. Of special importance for this second experiment is the development and validation of integrated design methods which include the benefits of active controls in the structural design.

An overview of large wind turbine tests by electric utilities

NASA Technical Reports Server (NTRS)

Vachon, W. A.; Schiff, D.

1982-01-01

A summary of recent plants and experiences on current large wind turbine (WT) tests being conducted by electric utilities is provided. The test programs discussed do not include federal research and development (R&D) programs, many of which are also being conducted in conjunction with electric utilities. The information presented is being assembled in a project, funded by the Electric Power Research Institute (EPRI), the objective of which is to provide electric utilities with timely summaries of test performance on key large wind turbines. A summary of key tests, test instrumentation, and recent results and plans is given. During the past year, many of the utility test programs initiated have encountered test difficulties that required specific WT design changes. However, test results to date continue to indicate that long-term machine performance and cost-effectiveness are achievable.

Open-Air Biowarfare Testing and the Evolution of Values

PubMed Central

2016-01-01

The United States and the United Kingdom ended outdoor biological warfare testing in populated areas nearly half a century ago. Yet, the conduct, health effects, and propriety of those tests remain controversial. The varied views reflect the limits of currently available test information and evolving societal values on research involving human subjects. Western political culture has changed since the early days of the American and British testing programs. People have become less reluctant to question authority, and institutional review boards must now pre-approve research involving human subjects. Further, the heightened stringency of laboratory containment has accentuated the safety gap between a confined test space and one without physical boundaries. All this makes it less likely that masses of people would again be unwittingly subjected to secret open-air biological warfare tests. PMID:27564984

The Validity and Responsiveness of Isometric Lower Body Multi-Joint Tests of Muscular Strength: a Systematic Review.

PubMed

Drake, David; Kennedy, Rodney; Wallace, Eric

2017-12-01

Researchers and practitioners working in sports medicine and science require valid tests to determine the effectiveness of interventions and enhance understanding of mechanisms underpinning adaptation. Such decision making is influenced by the supportive evidence describing the validity of tests within current research. The objective of this study is to review the validity of lower body isometric multi-joint tests ability to assess muscular strength and determine the current level of supporting evidence. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed in a systematic fashion to search, assess and synthesize existing literature on this topic. Electronic databases such as Web of Science, CINAHL and PubMed were searched up to 18 March 2015. Potential inclusions were screened against eligibility criteria relating to types of test, measurement instrument, properties of validity assessed and population group and were required to be published in English. The Consensus-based Standards for the Selection of health Measurement Instruments (COSMIN) checklist was used to assess methodological quality and measurement property rating of included studies. Studies rated as fair or better in methodological quality were included in the best evidence synthesis. Fifty-nine studies met the eligibility criteria for quality appraisal. The ten studies that rated fair or better in methodological quality were included in the best evidence synthesis. The most frequently investigated lower body isometric multi-joint tests for validity were the isometric mid-thigh pull and isometric squat. The validity of each of these tests was strong in terms of reliability and construct validity. The evidence for responsiveness of tests was found to be moderate for the isometric squat test and unknown for the isometric mid-thigh pull. No tests using the isometric leg press met the criteria for inclusion in the best evidence synthesis. Researchers and practitioners can use the isometric squat and isometric mid-thigh pull with confidence in terms of reliability and construct validity. Further work to investigate other validity components such as criterion validity, smallest detectable change and responsiveness to resistance exercise interventions may be beneficial to the current level of evidence.

Self-Reported HIV-Positive Status But Subsequent HIV-Negative Test Result Using Rapid Diagnostic Testing Algorithms Among Seven Sub-Saharan African Military Populations

DTIC Science & Technology

2017-07-07

RESEARCH ARTICLE Self-reported HIV-positive status but subsequent HIV-negative test result using rapid diagnostic testing algorithms among seven sub...America * judith.harbertson.ctr@mail.mil Abstract HIV rapid diagnostic tests (RDTs) combined in an algorithm are the current standard for HIV diagnosis...in many sub-Saharan African countries, and extensive laboratory testing has con- firmed HIV RDTs have excellent sensitivity and specificity. However

Comprehensive embryo testing. Experts' opinions regarding future directions: an expert panel study on comprehensive embryo testing.

PubMed

Hens, Kristien; Dondorp, Wybo J; Geraedts, Joep P M; de Wert, Guido M

2013-05-01

What do scientists in the field of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) consider to be the future direction of comprehensive embryo testing? Although there are many biological and technical limitations, as well as uncertainties regarding the meaning of genetic variation, comprehensive embryo testing will impact the IVF/PGD practice and a timely ethical reflection is needed. Comprehensive testing using microarrays is currently being introduced in the context of PGD and PGS, and it is to be expected that whole-genome sequencing will also follow. Current ethical and empirical sociological research on embryo testing focuses on PGD as it is practiced now. However, empirical research and systematic reflection regarding the impact of comprehensive techniques for embryo testing is missing. In order to understand the potential of this technology and to be able to adequately foresee its implications, we held an expert panel with seven pioneers in PGD. We conducted an expert panel in October 2011 with seven PGD pioneers from Belgium, The Netherlands, Germany and the UK. Participants expected the use of comprehensive techniques in the context of PGD. However, the introduction of these techniques in embryo testing requires timely ethical reflection as it involves a shift from choosing an embryo without a particular genetic disease (i.e. PGD) or most likely to result in a successful pregnancy (i.e. PGS) to choosing the best embryo based on a much wider set of criteria. Such ethical reflection should take account of current technical and biological limitations and also of current uncertainties with regard to the meaning of genetic variance. However, ethicists should also not be afraid to look into the future. There was a general agreement that embryo testing will be increasingly preceded by comprehensive preconception screening, thus enabling smart combinations of genetic testing. The group was composed of seven participants from four Western Europe countries. As willingness to participate in this study may be connected with expectations regarding the pace and direction of future developments, selection bias cannot be excluded. The introduction of comprehensive screening techniques in embryo testing calls for further ethical reflection that is grounded in empirical work. Specifically, there is a need for studies querying the opinions of infertile couples undergoing IVF/PGS regarding the desirability of embryo screening beyond aneuploidy. This research was supported by the CSG, Centre for Society and Life Sciences (project number: 70.1.074). The authors declare no conflict of interest. N/A.

Preparations for flight research to evaluate actuated forebody strakes on the F-18 high-alpha research vehicle

NASA Technical Reports Server (NTRS)

Murri, Daniel G.; Shah, Gautam H.; Dicarlo, Daniel J.

1994-01-01

As part of the NASA High-Angle-of-Attack Technology Program (HATP), flight tests are currently being conducted with a multi-axis thrust vectoring system applied to the NASA F-18 High Alpha Research Vehicle (HARV). A follow-on series of flight tests with the NASA F-18 HARV will be focusing on the application of actuated forebody strake controls. These controls are designed to provide increased levels of yaw control at high angles of attack where conventional aerodynamic controls become ineffective. The series of flight tests are collectively referred to as the Actuated Nose Strakes for Enhanced Rolling (ANSER) Flight Experiment. The development of actuated forebody strake controls for the F-18 HARV is discussed and a summary of the ground tests conducted in support of the flight experiment is provided. A summary of the preparations for the flight tests is also provided.

A critical review of the life sciences project management at Ames Research Center for the Spacelab Mission development test 3

NASA Technical Reports Server (NTRS)

Helmreich, R. L.; Wilhelm, J. M.; Tanner, T. A.; Sieber, J. E.; Burgenbauch, S. F.

1979-01-01

A management study was initiated by ARC (Ames Research Center) to specify Spacelab Mission Development Test 3 activities and problems. This report documents the problems encountered and provides conclusions and recommendations to project management for current and future ARC life sciences projects. An executive summary of the conclusions and recommendations is provided. The report also addresses broader issues relevant to the conduct of future scientific missions under the constraints imposed by the space environment.

The Utility of Testing Noncognitive Aptitudes as Additional Predictors of Graduation from U.S. Air Force Air Traffic Controller Training

DTIC Science & Technology

2015-11-13

Control The ability to resist or delay an impulse, drive, or temptation to act General Mood Happiness The ability to feel satisfied with one’s life...Neurostat Analytical Solutions as a consultant to the USAF School of Aero- space Medicine on numerous research projects. He currently researches suicide ...testing inter- ventions for suicidal military personnel at Fort Carson, Colorado. Dr. Bryan is a nationally-recognized expert on military suicide , and

Testing Iodine as a New Fuel for Cathodes

NASA Astrophysics Data System (ADS)

Glad, Harley; Branam, Richard; Rogers, Jim; Warren, Matthew; Burleson, Connor; Siy, Grace

2017-11-01

The objective of this research is to demonstrate the viability of using iodine as an alternative space propulsion propellant. The demonstration requires the testing of a cathode with xenon and then the desired element iodine. Currently, cathodes run on noble gases such as xenon which must be stored in high pressure canisters and is very expensive. These shortcomings have led to researching possible substitutes. Iodine was decided as a suitable candidate because it's cheaper, can be stored as a solid, and has similar mass properties as xenon. In this research, cathodes will be placed in a vacuum chamber and operated on both gases to observe their performance, allowing us to gain a better understanding of iodine's behavior. Several planned projects depend on the knowledge gained from this project, such as larger scaled tests and iodine fed hall thrusters. The tasks of this project included protecting the stainless-steel vacuum chamber by gold plating and Teflon® coating, building a stand to hold the cathode, creating an anode resistant to iodine, and testing the cathode once setup was complete. The successful operation of the cathode was demonstrated. However, the experimental setup proved ineffective at controlling the iodine flow. Current efforts are focused on this problem. REU Site: Fluid Mechanics with Analysis using Computations and Experiments NSF Grant EEC 1659710.

Risk of co-occuring psychopathology: testing a prediction of expectancy theory.

PubMed

Capron, Daniel W; Norr, Aaron M; Schmidt, Norman B

2013-01-01

Despite the high impact of anxiety sensitivity (AS; a fear of anxiety related sensations) research, almost no research attention has been paid to its parent theory, Reiss' expectancy theory (ET). ET has gone largely unexamined to this point, including the prediction that AS is a better predictor of number of fears than current anxiety. To test Reiss' prediction, we used a large (N = 317) clinical sample of anxiety outpatients. Specifically, we examined whether elevated AS predicted number of comorbid anxiety and non-anxiety disorder diagnoses in this sample. Consistent with ET, findings indicated that AS predicted number of comorbid anxiety disorder diagnoses above and beyond current anxiety symptoms. Also, AS did not predict the number of comorbid non-anxiety diagnoses when current anxiety symptoms were accounted for. These findings represent an important examination of a prediction of Reiss' ET and are consistent with the idea that AS may be a useful transdiagnostic treatment target. Copyright © 2012 Elsevier Ltd. All rights reserved.

Impact Testing of a Stirling Converter's Linear Alternator

NASA Technical Reports Server (NTRS)

Suarez, Vicente J.; Goodnight, Thomas W.; Hughes, William O.; Samorezov, Sergey

2002-01-01

The U.S. Department of Energy (DOE), in conjunction with the NASA John H. Glenn Research Center and Stirling Technology Company, are currently developing a Stirling convertor for a Stirling Radioisotope Generator (SRG). NASA Headquarters and DOE have identified the SRG for potential use as an advanced spacecraft power system for future NASA deep-space and Mars surface missions. Low-level dynamic impact tests were conducted at NASA Glenn Research Center's Structural Dynamics Laboratory as part of the development of this technology. The purpose of this test was to identify dynamic structural characteristics of the Stirling Technology Demonstration Convertor (TDC). This paper addresses the test setup, procedure, and results of the impact testing conducted on the Stirling TDC in May 2001.

Impact testing of a Stirling convertor's linear alternator

NASA Astrophysics Data System (ADS)

Suárez, Vicente J.; Goodnight, Thomas W.; Hughes, William O.; Samorezov, Sergey

2002-01-01

The U.S. Department of Energy (DOE), in conjunction with NASA John H. Glenn Research Center and Stirling Technology Company, are currently developing a Stirling convertor for a Stirling Radioisotope Generator (SRG). NASA Headquarters and DOE have identified the SRG for potential use as an advanced spacecraft power system for future NASA deep-space and Mars surface missions. Low-level dynamic impact tests were conducted at NASA Glenn Research Center's Structural Dynamics Laboratory as part of the development of this technology. The purpose of this test was to identify dynamic structural characteristics of the Stirling Technology Demonstration Convertor (TDC). This paper addresses the test setup, procedure and results of the impact testing conducted on the Stirling TDC in May 2001. .

Assessing effects of pesticides on amphibians and reptiles: status and needs

USGS Publications Warehouse

Hall, R.J.; Henry, P.F.P.

1992-01-01

Growing concern about the decline of certain amphibian populations and for conservation of amphibians and reptiles has led to renewed awareness of problems from pesticides. Testing amphibians and reptiles as a requirement for chemical registration has been proposed but is difficult because of the phylogenetic diversity of these groups. Information from the literature and research may determine whether amphibians and reptiles are adequately protected by current tests for mammals, birds, and fish. Existing information indicates that amphibians are unpredictably more resistant to certain cholinesterase inhibitors, and more sensitive to two chemicals used in fishery applications than could have been predicted. A single study on one species of lizard suggests that reptiles may be close in sensitivity to mammals and birds. Research on effects of pesticides on amphibians and reptiles should compare responses to currently tested groups and should seek to delineate those taxa and chemicals for which cross-group prediction is not possible. New tests for amphibians and reptiles should rely to the greatest extent possible on existing data bases, and should be designed for maximum economy and minimum harm to test animals. A strategy for developing the needed information is proposed. Good field testing and surveillance of chemicals in use may compensate for failures of predictive evaluations and may ultimately lead to improved tests.

Subscale Flight Testing for Aircraft Loss of Control: Accomplishments and Future Directions

NASA Technical Reports Server (NTRS)

Cox, David E.; Cunningham, Kevin; Jordan, Thomas L.

2012-01-01

Subscale flight-testing provides a means to validate both dynamic models and mitigation technologies in the high-risk flight conditions associated with aircraft loss of control. The Airborne Subscale Transport Aircraft Research (AirSTAR) facility was designed to be a flexible and efficient research facility to address this type of flight-testing. Over the last several years (2009-2011) it has been used to perform 58 research flights with an unmanned, remotely-piloted, dynamically-scaled airplane. This paper will present an overview of the facility and its architecture and summarize the experimental data collected. All flights to date have been conducted within visual range of a safety observer. Current plans for the facility include expanding the test volume to altitudes and distances well beyond visual range. The architecture and instrumentation changes associated with this upgrade will also be presented.

Detecting the position of the moving-iron solenoid by non-displacement sensor based on parameter identification of flux linkage characteristics

NASA Astrophysics Data System (ADS)

Wang, Xuping; Quan, Long; Xiong, Guangyu

2013-11-01

Currently, most researches use signals, such as the coil current or voltage of solenoid, to identify parameters; typically, parameter identification method based on variation rate of coil current is applied for position estimation. The problem exists in these researches that the detected signals are prone to interference and difficult to obtain. This paper proposes a new method for detecting the core position by using flux characteristic quantity, which adds a new group of secondary winding to the coil of the ordinary switching electromagnet. On the basis of electromagnetic coupling theory analysis and simulation research of the magnetic field regarding the primary and secondary winding coils, and in accordance with the fact that under PWM control mode varying core position and operating current of windings produce different characteristic of flux increment of the secondary winding. The flux increment of the electromagnet winding can be obtained by conducting time domain integration for the induced voltage signal of the extracted secondary winding, and the core position from the two-dimensional fitting curve of the operating winding current and flux-linkage characteristic quantity of solenoid are calculated. The detecting and testing system of solenoid core position is developed based on the theoretical research. The testing results show that the flux characteristic quantity of switching electromagnet magnetic circuit is able to effectively show the core position and thus to accomplish the non-displacement transducer detection of the said core position of the switching electromagnet. This paper proposes a new method for detecting the core position by using flux characteristic quantity, which provides a new theory and method for switch solenoid to control the proportional valve.

Spectral Mismatch Corrections Video Text Version | Photovoltaic Research |

Science.gov Websites

reference cell with the spectral or spot similar to a test cell will make it easier to account for the goes into the numerator of M. Second, we measure the short circuit current of the test cell under the measure the EQE of the test cell and multiply the AM 1.5G solar spectrum to calculate its short circuit

Neither Fair nor Accurate: Research-Based Reasons Why High-Stakes Tests Should Not Be Used to Evaluate Teachers

ERIC Educational Resources Information Center

Au, Wayne

2011-01-01

Current and former leaders of many major urban school districts, including Washington, D.C.'s Michelle Rhee and New Orleans' Paul Vallas, have sought to use tests to evaluate teachers. In fact, the use of high-stakes standardized tests to evaluate teacher performance in the manner of value-added measurement (VAM) has become one of the cornerstones…

Advanced Fiber Optic-Based Sensing Technology for Unmanned Aircraft Systems

NASA Technical Reports Server (NTRS)

Richards, Lance; Parker, Allen R.; Piazza, Anthony; Ko, William L.; Chan, Patrick; Bakalyar, John

2011-01-01

This presentation provides an overview of fiber optic sensing technology development activities performed at NASA Dryden in support of Unmanned Aircraft Systems. Examples of current and previous work are presented in the following categories: algorithm development, system development, instrumentation installation, ground R&D, and flight testing. Examples of current research and development activities are provided.

The first research plantings of third-generation, third-backcross American chestnut (Castanea dentata) in the southeastern United States

Treesearch

Stacy Clark; S.E. Schlarbaum; F,V Saxton

2014-01-01

Production of American chestnut (Castanea dentata) resistant to the chestnut blight fungus (Cryphonectria parasitica) is being conducted currently through traditional breeding and genetic transformation. Sufficient material for field testing is currently available from The American Chestnut Foundation’s backcross breeding program. We planted approximately 4500 chestnut...

Recent Advances in Simulation of Eddy Current Testing of Tubes and Experimental Validations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reboud, C.; Premel, D.; Lesselier, D.

2007-03-21

Eddy current testing (ECT) is widely used in iron and steel industry for the inspection of tubes during manufacturing. A collaboration between CEA and the Vallourec Research Center led to the development of new numerical functionalities dedicated to the simulation of ECT of non-magnetic tubes by external probes. The achievement of experimental validations led us to the integration of these models into the CIVA platform. Modeling approach and validation results are discussed here. A new numerical scheme is also proposed in order to improve the accuracy of the model.

Recent Advances in Simulation of Eddy Current Testing of Tubes and Experimental Validations

NASA Astrophysics Data System (ADS)

Reboud, C.; Prémel, D.; Lesselier, D.; Bisiaux, B.

2007-03-01

Eddy current testing (ECT) is widely used in iron and steel industry for the inspection of tubes during manufacturing. A collaboration between CEA and the Vallourec Research Center led to the development of new numerical functionalities dedicated to the simulation of ECT of non-magnetic tubes by external probes. The achievement of experimental validations led us to the integration of these models into the CIVA platform. Modeling approach and validation results are discussed here. A new numerical scheme is also proposed in order to improve the accuracy of the model.

A Comparison of Mother-Tongue Curricula of Successful Countries in PISA and Turkey by Higher-Order Thinking Processes

ERIC Educational Resources Information Center

Cer, Erkan

2018-01-01

Purpose: The purpose of the current study is to reveal general qualities of the objectives in the mother-tongue curricula of Hong Kong and Shanghai-China, South Korea, Singapore, and Turkey in terms of higher-order thinking processes specified by PISA tests. Research Methods: In this study, the researcher used a qualitative research design.…

Investigating electrical resonance in eddy-current array probes

NASA Astrophysics Data System (ADS)

Hughes, R.; Fan, Y.; Dixon, S.

2016-02-01

The sensitivity enhancing effects of eddy-current testing at frequencies close to electrical resonance are explored. Var-ied techniques exploiting the phenomenon, dubbed near electrical resonance signal enhancement (NERSE), were experimentally investigated to evaluate its potential exploitation for other interesting applications in aerospace materials, in particular its potential for boosting the sensitivity of standard ECT measurements. Methods for setting and controlling the typically unstable resonant frequencies of such systems are discussed. This research is funded by the EPSRC, via the Research Centre for Non-Destructive Evaluation RCNDE, and Rolls-Royce plc.

History and Evolution of the Johnson Criteria.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjaardema, Tracy A.; Smith, Collin S.; Birch, Gabriel Carisle

The Johnson Criteria metric calculates probability of detection of an object imaged by an optical system, and was created in 1958 by John Johnson. As understanding of target detection has improved, detection models have evolved to better model additional factors such as weather, scene content, and object placement. The initial Johnson Criteria, while sufficient for technology and understanding at the time, does not accurately reflect current research into target acquisition and technology. Even though current research shows a dependence on human factors, there appears to be a lack of testing and modeling of human variability.

What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.

PubMed

Ravignani, Andrea; Fitch, W Tecumseh; Hanke, Frederike D; Heinrich, Tamara; Hurgitsch, Bettina; Kotz, Sonja A; Scharff, Constance; Stoeger, Angela S; de Boer, Bart

2016-01-01

Research on the evolution of human speech and music benefits from hypotheses and data generated in a number of disciplines. The purpose of this article is to illustrate the high relevance of pinniped research for the study of speech, musical rhythm, and their origins, bridging and complementing current research on primates and birds. We briefly discuss speech, vocal learning, and rhythm from an evolutionary and comparative perspective. We review the current state of the art on pinniped communication and behavior relevant to the evolution of human speech and music, showing interesting parallels to hypotheses on rhythmic behavior in early hominids. We suggest future research directions in terms of species to test and empirical data needed.

What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm

PubMed Central

Ravignani, Andrea; Fitch, W. Tecumseh; Hanke, Frederike D.; Heinrich, Tamara; Hurgitsch, Bettina; Kotz, Sonja A.; Scharff, Constance; Stoeger, Angela S.; de Boer, Bart

2016-01-01

Research on the evolution of human speech and music benefits from hypotheses and data generated in a number of disciplines. The purpose of this article is to illustrate the high relevance of pinniped research for the study of speech, musical rhythm, and their origins, bridging and complementing current research on primates and birds. We briefly discuss speech, vocal learning, and rhythm from an evolutionary and comparative perspective. We review the current state of the art on pinniped communication and behavior relevant to the evolution of human speech and music, showing interesting parallels to hypotheses on rhythmic behavior in early hominids. We suggest future research directions in terms of species to test and empirical data needed. PMID:27378843

Prioritization in comparative effectiveness research: the CANCERGEN Experience.

PubMed

Thariani, Rahber; Wong, William; Carlson, Josh J; Garrison, Louis; Ramsey, Scott; Deverka, Patricia A; Esmail, Laura; Rangarao, Sneha; Hoban, Carolyn J; Baker, Laurence H; Veenstra, David L

2012-05-01

Systematic approaches to stakeholder-informed research prioritization are a central focus of comparative effectiveness research. Genomic testing in cancer is an ideal area to refine such approaches given rapid innovation and potentially significant impacts on patient outcomes. To develop and pilot test a stakeholder-informed approach to prioritizing genomic tests for future study in collaboration with the cancer clinical trials consortium SWOG. We conducted a landscape analysis to identify genomic tests in oncology using a systematic search of published and unpublished studies, and expert consultation. Clinically valid tests suitable for evaluation in a comparative study were presented to an external stakeholder group. Domains to guide the prioritization process were identified with stakeholder input, and stakeholders ranked tests using multiple voting rounds. A stakeholder group was created including representatives from patient-advocacy groups, payers, test developers, regulators, policy makers, and community-based oncologists. We identified 9 domains for research prioritization with stakeholder feedback: population impact; current standard of care, strength of association; potential clinical benefits, potential clinical harms, economic impacts, evidence of need, trial feasibility, and market factors. The landscape analysis identified 635 studies; of 9 tests deemed to have sufficient clinical validity, 6 were presented to stakeholders. Two tests in lung cancer (ERCC1 and EGFR) and 1 test in breast cancer (CEA/CA15-3/CA27.29) were identified as top research priorities. Use of a diverse stakeholder group to inform research prioritization is feasible in a pragmatic and timely manner. Additional research is needed to optimize search strategies, stakeholder group composition, and integration with existing prioritization mechanisms.

Prioritization in Comparative Effectiveness Research: The CANCERGEN Experience in Cancer Genomics

PubMed Central

Thariani, Rahber; Wong, William; Carlson, Josh J; Garrison, Louis; Ramsey, Scott; Deverka, Patricia A; Esmail, Laura; Rangarao, Sneha; Hoban, Carolyn J; Baker, Laurence H; Veenstra, David L

2012-01-01

Background Systematic approaches to stakeholder-informed research prioritization are a central focus of comparative effectiveness research. Genomic testing in cancer is an ideal area to refine such approaches given rapid innovation and potentially significant impacts on patient outcomes. Objective To develop and pilot-test a stakeholder-informed approach to prioritizing genomic tests for future study in collaboration with the cancer clinical trials consortium SWOG. Methods We conducted a landscape-analysis to identify genomic tests in oncology using a systematic search of published and unpublished studies, and expert consultation. Clinically valid tests suitable for evaluation in a comparative study were presented to an external stakeholder group. Domains to guide the prioritization process were identified with stakeholder input, and stakeholders ranked tests using multiple voting rounds. Results A stakeholder group was created including representatives from patient-advocacy groups, payers, test developers, regulators, policy-makers, and community-based oncologists. We identified nine domains for research prioritization with stakeholder feedback: population impact; current standard of care, strength of association; potential clinical benefits, potential clinical harms, economic impacts, evidence of need, trial feasibility, and market factors. The landscape-analysis identified 635 studies; of 9 tests deemed to have sufficient clinical validity, 6 were presented to stakeholders. Two tests in lung cancer (ERCC1 and EGFR) and one test in breast cancer (CEA/CA15-3/CA27.29) were identified as top research priorities. Conclusions Use of a diverse stakeholder group to inform research prioritization is feasible in a pragmatic and timely manner. Additional research is needed to optimize search strategies, stakeholder group composition and integration with existing prioritization mechanisms. PMID:22274803

Mathematical-Programming Approaches to Test Item Pool Design. Research Report.

ERIC Educational Resources Information Center

Veldkamp, Bernard P.; van der Linden, Wim J.; Ariel, Adelaide

This paper presents an approach to item pool design that has the potential to improve on the quality of current item pools in educational and psychological testing and thus to increase both measurement precision and validity. The approach consists of the application of mathematical programming techniques to calculate optimal blueprints for item…

Family Environments, Adrenarche, and Sexual Maturation: A Longitudinal Test of a Life History Model

ERIC Educational Resources Information Center

Ellis, Bruce J.; Essex, Marilyn J.

2007-01-01

Life history theorists have proposed that humans have evolved to be sensitive to specific features of early childhood environments and that exposure to different environments biases children toward development of different reproductive strategies, including differential pubertal timing. The current research provides a longitudinal test of this…

On the Concept "Microscope": Biology Student Teachers' Cognitive Structure

ERIC Educational Resources Information Center

Kurt, Hakan; Ekici, Gulay; Aktas, Murat; Aksu, Ozlem

2013-01-01

The purpose of the current study is to determine biology student teachers' cognitive structures on the concept of microscope. Qualitative research methodology has been applied in the study. The data were collected from biology student teachers. Free word association test and drawing-writing test were used to collect data. The data collected were…

78 FR 52128 - Cotton Classing, Testing and Standards: Notice of Request for an Extension and Revision to a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-22

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [AMS-CN-13-0044] Cotton Classing, Testing..., for an extension and revision to the currently approved information collection entitled Cotton... proposal to: Shethir M. Riva, Chief, Research and Promotion Staff, Cotton and Tobacco Programs, AMS, USDA...

Alternatives to in vivo Tests to Detect Endocrine Disrupting Chemicals (EDCs) in Fish and Amphibians

EPA Science Inventory

A significant amount of current research in risk assessment of chemicals is targeted to evaluate alternative test methods that may reduce, replace or refine the use of animals, while ensuring human and environmental health and safety. In 2009, the US EPA began implementation of t...

A Multiple Mediational Test of the Relationship between Childhood Maltreatment and Non-Suicidal Self-Injury

ERIC Educational Resources Information Center

Shenk, Chad E.; Noll, Jennie G.; Cassarly, Jennifer A.

2010-01-01

Post-traumatic stress symptoms, depressive symptoms, and psychological dysregulation have been shown to mediate the relationship between child maltreatment and non-suicidal self-injury. However, these proposed mediators often co-occur and previous research has not tested mediation when all variables are assessed simultaneously. The current study…

Perceived Deep-Level Dissimilarity: Personality Antecedents and Impact on Overall Job Attitude, Helping, Work Withdrawal, and Turnover

ERIC Educational Resources Information Center

Liao, Hui; Chuang, Aichia; Joshi, Aparna

2008-01-01

The current research extends three research areas in relational demography: considering deep-level dissimilarity in theory building, assessing dissimilarity perceptions directly in theory testing, and examining the antecedents of dissimilarity perceptions. The results, based on two field studies using diverse samples, demonstrate the effects of…

Nice Thinking! an Educational Intervention That Teaches Children to Think Gratefully

ERIC Educational Resources Information Center

Froh, Jeffrey J.; Bono, Giacomo; Fan, Jinyan; Emmons, Robert A.; Henderson, Katherine; Harris, Cheray; Leggio, Heather; Wood, Alex M.

2014-01-01

Gratitude is essential to social life and well-being. Although research with youth populations has gained momentum recently, only two gratitude interventions have been conducted in youth, targeting mostly adolescents. In the current research, we tested a new intervention for promoting gratitude among the youngest children targeted to date.…

Improving the Validity of Quantitative Measures in Applied Linguistics Research

ERIC Educational Resources Information Center

Purpura, James E.; Brown, James Dean; Schoonen, Rob

2015-01-01

In empirical applied linguistics research it is essential that the key variables are operationalized in a valid and reliable way, and that the scores are treated appropriately, allowing for a proper testing of the hypotheses under investigation. The current article addresses several theoretical and practical issues regarding the use of measurement…

The Need to Introduce System Thinking in Teaching Climate Change

ERIC Educational Resources Information Center

Roychoudhury, Anita; Shepardson, Daniel P.; Hirsch, Andrew; Niyogi, Devdutta; Mehta, Jignesh; Top, Sara

2017-01-01

Research related to teaching climate change, system thinking, current reform in science education, and the research on reform-oriented assessment indicate that we need to explore student understanding in greater detail instead of only testing for an incremental gain in disciplinary knowledge. Using open-ended items we assessed details in student…

Current Research on Englishes in Southeast Asia

ERIC Educational Resources Information Center

Pakir, Anne

2010-01-01

Much research on world Englishes (WE) since the 1980s has yet to impact significantly upon recent applied linguistics work in the areas of instruction, curriculum, testing and policy. Much of the received wisdom has been informed by the paradigm established by the earlier study of International English (IE) and its attendant foci in teaching…

Feminist Identity Development: The Current State of Theory, Research, and Practice

ERIC Educational Resources Information Center

Hyde, Janet Shibley

2002-01-01

A review of the three articles on feminist identity development in this issue indicates that (a) the Feminist Identity Development Scale (FIDS) and the Feminist Identity Composite (FIC) perform similarly and acceptably in psychometric analyses, (b) no research has properly tested whether there are true stages of feminist identity development, and…

The Impact of Animal Rights on the Use of Animals for Biomedical Research, Product Testing and Evaluation.

ERIC Educational Resources Information Center

Baier, Stephen W.

1993-01-01

Clarifies the issues of animal rights as they effect animal use in research and education through an examination of the current use of animals, a historical look at animal use, and a consideration of the philosophical underpinnings of the animal rights and pro-use viewpoints. (PR)

The Importance of Comparative Research in Psychological Preparation of Children.

ERIC Educational Resources Information Center

Peterson, Lizette

Current research indicates that hospitalized children may profit best from preparation for surgery that is individually suited to their particular way of responding to hospitalization. It is likely, however, that preparation treatments will be provided for children in groups. Therefore, an attempt has been made to design and test information and…

Accuracy in Student Self-Assessment: Directions and Cautions for Research

ERIC Educational Resources Information Center

Brown, Gavin T. L.; Andrade, Heidi L.; Chen, Fei

2015-01-01

Student self-assessment is a central component of current conceptions of formative and classroom assessment. The research on self-assessment has focused on its efficacy in promoting both academic achievement and self-regulated learning, with little concern for issues of validity. Because reliability of testing is considered a sine qua non for the…

Reducing animal experimentation in foot-and-mouth disease vaccine potency tests.

PubMed

Reeve, Richard; Cox, Sarah; Smitsaart, Eliana; Beascoechea, Claudia Perez; Haas, Bernd; Maradei, Eduardo; Haydon, Daniel T; Barnett, Paul

2011-07-26

The World Organisation for Animal Health (OIE) Terrestrial Manual and the European Pharmacopoeia (EP) still prescribe live challenge experiments for foot-and-mouth disease virus (FMDV) immunogenicity and vaccine potency tests. However, the EP allows for other validated tests for the latter, and specifically in vitro tests if a "satisfactory pass level" has been determined; serological replacements are also currently in use in South America. Much research has therefore focused on validating both ex vivo and in vitro tests to replace live challenge. However, insufficient attention has been given to the sensitivity and specificity of the "gold standard"in vivo test being replaced, despite this information being critical to determining what should be required of its replacement. This paper aims to redress this imbalance by examining the current live challenge tests and their associated statistics and determining the confidence that we can have in them, thereby setting a standard for candidate replacements. It determines that the statistics associated with the current EP PD(50) test are inappropriate given our domain knowledge, but that the OIE test statistics are satisfactory. However, it has also identified a new set of live animal challenge test regimes that provide similar sensitivity and specificity to all of the currently used OIE tests using fewer animals (16 including controls), and can also provide further savings in live animal experiments in exchange for small reductions in sensitivity and specificity. Copyright © 2011 Elsevier Ltd. All rights reserved.

Can Immunotherapy Succeed in Glioblastoma?

Cancer.gov

Researchers are hopeful that, for the deadly brain cancer glioblastoma, immunotherapy might succeed where other therapies have not. As this Cancer Currents post reports, different immunotherapy approaches are being tested in clinical trials.

Caution and Warning Alarm Design and Evaluation for NASA CEV Auditory Displays: SHFE Information Presentation Directed Research Project (DRPP) report 12.07

NASA Technical Reports Server (NTRS)

Begault, Durand R.; Godfroy, Martine; Sandor, Aniko; Holden, Kritina

2008-01-01

The design of caution-warning signals for NASA s Crew Exploration Vehicle (CEV) and other future spacecraft will be based on both best practices based on current research and evaluation of current alarms. A design approach is presented based upon cross-disciplinary examination of psychoacoustic research, human factors experience, aerospace practices, and acoustical engineering requirements. A listening test with thirteen participants was performed involving ranking and grading of current and newly developed caution-warning stimuli under three conditions: (1) alarm levels adjusted for compliance with ISO 7731, "Danger signals for work places - Auditory Danger Signals", (2) alarm levels adjusted to an overall 15 dBA s/n ratio and (3) simulated codec low-pass filtering. Questionnaire data yielded useful insights regarding cognitive associations with the sounds.

Eddy Current Influences on the Dynamic Behaviour of Magnetic Suspension Systems

NASA Technical Reports Server (NTRS)

Britcher, Colin P.; Bloodgood, Dale V.

1998-01-01

This report will summarize some results from a multi-year research effort at NASA Langley Research Center aimed at the development of an improved capability for practical modelling of eddy current effects in magnetic suspension systems. Particular attention is paid to large-gap systems, although generic results applicable to both large-gap and small-gap systems are presented. It is shown that eddy currents can significantly affect the dynamic behavior of magnetic suspension systems, but that these effects can be amenable to modelling and measurement. Theoretical frameworks are presented, together with comparisons of computed and experimental data particularly related to the Large Angle Magnetic Suspension Test Fixture at NASA Langley Research Center, and the Annular Suspension and Pointing System at Old Dominion University. In both cases, practical computations are capable of providing reasonable estimates of important performance-related parameters. The most difficult case is seen to be that of eddy currents in highly permeable material, due to the low skin depths. Problems associated with specification of material properties and areas for future research are discussed.

Heat Pipes and Heat Rejection Component Testing at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Sanzi, James L.; Jaworske, Donald A.

2012-01-01

Titanium-water heat pipes are being evaluated for use in the heat rejection system for space fission power systems. The heat rejection syst em currently comprises heat pipes with a graphite saddle and a composite fin. The heat input is a pumped water loop from the cooling of the power conversion system. The National Aeronautics and Space Administration has been life testing titanium-water heat pipes as well as eval uating several heat pipe radiator designs. The testing includes thermal modeling and verification of model, material compatibility, frozen startup of heat pipe radiators, and simulating low-gravity environments. Future thermal testing of titanium-water heat pipes includes low-g ravity testing of thermosyphons, radiation testing of heat pipes and fin materials, water pump performance testing, as well as Small Busine ss Innovation Research funded deliverable prototype radiator panels.

Saudi views on consenting for research on medical records and leftover tissue samples

PubMed Central

2010-01-01

Background Consenting for retrospective medical records-based research (MR) and leftover tissue-based research (TR) continues to be controversial. Our objective was to survey Saudis attending outpatient clinics at a tertiary care hospital on their personal preference and perceptions of norm and current practice in relation to consenting for MR and TR. Methods We surveyed 528 Saudis attending clinics at a tertiary care hospital in Saudi Arabia to explore their preferences and perceptions of norm and current practice. The respondents selected one of 7 options from each of 6 questionnaires. Results Respondents' mean (SD) age was 33 (11) years, 42% were males, 56% were patients, 84% had ≥ secondary school education, and 10% had previously volunteered for research. Respectively, 40% and 49% perceived that the norm is to conduct MR and TR without consent and 38% and 37% with general or proposal-specific consent; the rest objected to such research. There was significant difference in the distribution of choices according to health status (patients vs. companions) for MR (adjusted Kruskal-Wallis test P = 0.03) but not to age group, gender, education level, or previous participation in research (unadjusted P = 0.02 - 0.59). The distributions of perceptions of current practice and norm were similar (unadjusted Marginal Homogeneity test P = 0.44 for MR and P = 0.89 for TR), whereas the distributions of preferences and perceptions of norm were different (adjusted P = 0.09 for MR and P = 0.02 for TR). The distributions of perceptions of norm, preferences, and perceptions of current practice for MR were significantly different from those of TR (adjusted P < 0.009 for all). Conclusions We conclude that: 1) there is a considerable diversity among Saudi views regarding consenting for retrospective research which may be related to health status, 2) the distribution of perceptions of norm was similar to the distribution of perceptions of current practice but different from that of preferences, and 3) MR and TR are perceived differently in regard to consenting. PMID:20955580

Overview of the Orion Vibroacoustic Test Capability at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Hughes, William O.; Hozman, Aron D.; McNelis, Mark E.; Otten, Kim D.

2008-01-01

In order to support the environmental test needs for our new Orion and Constellation program, NASA is developing unique world-class test facilities. To optimize this testing of spaceflight hardware while minimizing transportation issues, a one-stop, under one roof test capability is being developed at the Space Power Facility at the NASA Glenn Research Center's Plum Brook Station. This facility will provide the capability to perform the following environmental testing: (1) reverberation acoustic testing, (2) mechanical base-shake sine testing, (3) modal testing, (4) thermal-vacuum testing, and (5) EMI/EMC (electromagnetic interference and compatibility) testing. An overview of this test capability will be provided in this presentation, with special focus on the two new vibroacoustic test facilities currently being designed and built, the Reverberant Acoustic Test Facility (RATF) and the Mechanical Vibration Facility (MVF). Testing of the engineering developmental hardware and qualification hardware of the Orion (Crew Exploration Vehicle) will commence shortly after the facilities are commissioned.

Investigation of reliability attributes and accelerated stress factors of terrestrial solar cells. First annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prince, J.L.; Lathrop, J.W.

1979-05-01

The results of accelerated stress testing of four different types of silicon terrestrial solar cells are discussed. The accelerated stress tests used included bias-temperature tests, bias-temperature-humidity tests, thermal cycle and thermal shock tests, and power cycle tests. Characterization of the cells was performed before stress testing and at periodic down-times, using electrical measurement, visual inspection, and metal adherence pull tests. Electrical parameters measured included short-circuit current, I/sub sc/, open circuit voltage, V/sub oc/, and output power, voltage, and current at the maximum power point, P/sub m/, V/sub m/, and I/sub m/ respectively. Incorporated in the report are the distributions ofmore » the prestress electrical data for all cell types. Data was also obtained on cell series and shunt resistance. Significant differences in the response to the various stress tests was observed between cell types. On the basis of the experience gained in this research work, a suggested Reliability Qualification Test Schedule was developed.« less

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

PubMed Central

YOUNG, Jared W; POWELL, Susan; RISBROUGH, Victoria; MARSTON, Hugh M; GEYER, Mark A

2009-01-01

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate with functional outcome, and are not well treated with current antipsychotic therapies. In order to bring together academic, industrial, and governmental bodies to address this great ‘unmet therapeutic need’, the NIMH sponsored the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. Through careful factor analysis and consensus of expert opinion, MATRICS identified seven domains of cognition that are deficient in schizophrenia (attention/vigilance, working memory, reasoning and problem solving, processing speed, visual learning and memory, verbal learning and memory, and social cognition) and recommended a specific neuropsychological test battery to probe these domains. In order to move the field forward and outline an approach for translational research, there is a need for a “preclinical MATRICS” to develop a rodent test battery that is appropriate for drug development. In this review, we outline such an approach and review current rodent tasks that target these seven domains of cognition. The rodent tasks are discussed in terms of their validity for probing each cognitive domain as well as a brief overview of the pharmacology and manipulations relevant to schizophrenia for each task. PMID:19269307

Multiple Sclerosis: Hope through Research

MedlinePlus

... been a valuable tool to test whether an experimental new therapy is effective at reducing exacerbations. top ... that they will require aggressive and perhaps even experimental treatment. The current FDA-approved therapies for MS ...

Test Rack Development for Extended Operation of Advanced Stirling Convertors at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Dugala, Gina M.

2010-01-01

The U.S. Department of Energy, Lockheed Martin Space Systems Company, Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science missions. This generator will make use of free-piston Stirling convertors to achieve higher conversion efficiency than with currently available alternatives. One part of NASA GRC's support of ASRG development includes extended operation testing of Advanced Stirling Convertors (ASCs) developed by Sunpower Inc. and GRC. The ASC consists of a free-piston Stirling engine integrated with a linear alternator. NASA GRC has been building test facilities to support extended operation of the ASCs for several years. Operation of the convertors in the test facility provides convertor performance data over an extended period of time. One part of the test facility is the test rack, which provides a means for data collection, convertor control, and safe operation. Over the years, the test rack requirements have changed. The initial ASC test rack utilized an alternating-current (AC) bus for convertor control; the ASRG Engineering Unit (EU) test rack can operate with AC bus control or with an ASC Control Unit (ACU). A new test rack is being developed to support extended operation of the ASC-E2s with higher standards of documentation, component selection, and assembly practices. This paper discusses the differences among the ASC, ASRG EU, and ASC-E2 test racks.

Debates—Hypothesis testing in hydrology: Theory and practice

NASA Astrophysics Data System (ADS)

Pfister, Laurent; Kirchner, James W.

2017-03-01

The basic structure of the scientific method—at least in its idealized form—is widely championed as a recipe for scientific progress, but the day-to-day practice may be different. Here, we explore the spectrum of current practice in hypothesis formulation and testing in hydrology, based on a random sample of recent research papers. This analysis suggests that in hydrology, as in other fields, hypothesis formulation and testing rarely correspond to the idealized model of the scientific method. Practices such as "p-hacking" or "HARKing" (Hypothesizing After the Results are Known) are major obstacles to more rigorous hypothesis testing in hydrology, along with the well-known problem of confirmation bias—the tendency to value and trust confirmations more than refutations—among both researchers and reviewers. Nonetheless, as several examples illustrate, hypothesis tests have played an essential role in spurring major advances in hydrological theory. Hypothesis testing is not the only recipe for scientific progress, however. Exploratory research, driven by innovations in measurement and observation, has also underlain many key advances. Further improvements in observation and measurement will be vital to both exploratory research and hypothesis testing, and thus to advancing the science of hydrology.

Hyper-X Research Vehicle (HXRV) Experimental Aerodynamics Test Program Overview

NASA Technical Reports Server (NTRS)

Holland, Scott D.; Woods, William C.; Engelund, Walter C.

2000-01-01

This paper provides an overview of the experimental aerodynamics test program to ensure mission success for the autonomous flight of the Hyper-X Research Vehicle (HXRV). The HXRV is a 12-ft long, 2700 lb lifting body technology demonstrator designed to flight demonstrate for the first time a fully airframe integrated scramjet propulsion system. Three flights are currently planned, two at Mach 7 and one at Mach 10, beginning in the fall of 2000. The research vehicles will be boosted to the prescribed scramjet engine test point where they will separate from the booster, stabilize. and initiate engine test. Following 5+ seconds of powered flight and 15 seconds of cowl-open tares, the cowl will close and the vehicle will fly a controlled deceleration trajectory which includes numerous control doublets for in-flight aerodynamic parameter identification. This paper reviews the preflight testing activities, wind tunnel models, test rationale. risk reduction activities, and sample results from wind tunnel tests supporting the flight trajectory of the HXRV from hypersonic engine test point through subsonic flight termination.

Hyper-X Research Vehicle (HXRV) Experimental Aerodynamics Test Program Overview

NASA Technical Reports Server (NTRS)

Holland, Scott D.; Woods, William C.; Engelund, Walter C.

2000-01-01

This paper provides an overview of the experimental aerodynamics test program to ensure mission success for the autonomous flight of the Hyper-X Research Vehicle (HXRV). The HXRV is a 12-ft long, 2700 lb lifting body technology demonstrator designed to flight demonstrate for the first time a fully airframe integrated scramjet propulsion system. Three flights are currently planned, two at Mach 7 and one at Mach 10, beginning in the fall of 2000. The research vehicles will be boosted to the prescribed scramjet engine test point where they will separate from the booster, stabilize, and initiate engine test. Following 5+ seconds of powered flight and 15 seconds of cow-open tares, the cowl will close and the vehicle will fly a controlled deceleration trajectory which includes numerous control doublets for in-flight aerodynamic parameter identification. This paper reviews the preflight testing activities, wind tunnel models, test rationale, risk reduction activities, and sample results from wind tunnel tests supporting the flight trajectory of the HXRV from hypersonic engine test point through subsonic flight termination.

Farfield Ion Current Density Measurements before and after the NASA HiVHAc EDU2 Vibration Test

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Kamhawi, Hani; Shastry, Rohit

2012-01-01

There is an increasing need to characterize the plasma plume of the NASA HiVHAc thruster in order to better understand the plasma physics and to obtain data for spacecraft interaction studies. To address this need, the HiVHAc research team is in the process of developing a number of plume diagnostic systems. This paper presents the initial results of the farfield current density probe diagnostic system. Farfield current density measurements were carried out before and after a vibration test of the HiVHAc engineering development unit 2 that simulate typical launch conditions. The main purposes of the current density measurements were to evaluate the thruster plume divergence and to investigate any changes in the plasma plume that may occur as a result of the vibration test. Radial sweeps, as opposed to the traditional polar sweeps, were performed during these tests. The charged-weighted divergence angles were found to vary from 16 to 28 degrees. Charge density profiles measured pre- and post-vibration-test were found to be in excellent agreement. This result, alongside thrust measurements reported in a companion paper, confirm that the operation of the HiVHAc engineering development unit 2 were not altered by full-level/random vibration testing.

Current and experimental treatments of Parkinson disease: A guide for neuroscientists.

PubMed

Oertel, Wolfgang; Schulz, Jörg B

2016-10-01

Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been optimized using pharmacotherapy, deep brain stimulation, and physiotherapy. The arsenal of pharmacotherapies includes L-Dopa, several dopamine agonists, inhibitors of monoamine oxidase (MAO)-B and catechol-o-methyltransferase (COMT), and amantadine. In the later course of the disease, motor complications occur, at which stage different oral formulations of L-Dopa or dopamine agonists with long half-life, a transdermal application or parenteral pumps for continuous drug supply can be subscribed. Alternatively, the patient is offered deep brain stimulation of the subthalamic nucleus (STN) or the internal part of the globus pallidus (GPi). For a more efficacious treatment of motor complications, new formulations of L-Dopa, dopamine agonists, and amantadine as well as new MAO-B and COMT inhibitors are currently tested in clinical trials, and some of them already yielding positive results in phase 3 trials. In addition, non-dopaminergic agents have been tested in the early clinical phase for the treatment of motor fluctuations and dyskinesia, including adenosine A2A antagonists (istradefylline, preladenant, and tozadenant) and modulators of the metabolic glutamate receptor 5 (mGluR5 - mavoglurant) and serotonin (eltoprazine) receptors. Recent clinical trials testing coenzyme Q10, the dopamine agonist pramipexole, creatine monohydrate, pioglitazone, or AAV-mediated gene therapy aimed at increasing expression of neurturin, did not prove efficacious. Treatment with nicotine, caffeine, inosine (a precursor of urate), and isradipine (a dihydropyridine calcium channel blocker), as well as active and passive immunization against α-synuclein and inhibitors or modulators of α-synuclein-aggregation are currently studied in clinical trials. However, to date, no disease-modifying treatment is available. We here review the current status of treatment options for motor and non-motor symptoms, and discuss current investigative strategies for disease modification. This review provides basic insights, mainly addressing basic scientists and non-specialists. It stresses the need to intensify therapeutic PD research and points out reasons why the translation of basic research to disease-modifying therapies has been unsuccessful so far. The symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been constantly optimized using pharmacotherapy (L-Dopa, several dopamine agonists, inhibitors of monoamine oxidase (MAO)-B and catechol-o-methyltransferase (COMT), and amantadine), deep brain stimulation, and physiotherapy. For a more efficacious treatment of motor complications, new formulations of L-Dopa, dopamine agonists, and amantadine as well as new MAO-B and COMT inhibitors are currently tested in clinical trials. Non-dopaminergic agents have been tested in the early clinical phase for the treatment of motor fluctuations and dyskinesia. Recent clinical trials testing coenzyme Q10, the dopamine agonist pramipexole, creatine monohydrate, pioglitazone, or AAV-mediated gene therapy aimed at increasing expression of neurturin, did not prove efficacious. Treatment with nicotine, caffeine, and isradipine - a dihydropyridine calcium channel blocker - as well as active and passive immunization against α-synuclein and inhibitors of α-synuclein-aggregation are currently studied in clinical trials. However, to date, no disease-modifying treatment is available for PD. We here review the current status of treatment options and investigative strategies for both motor and non-motor symptoms. This review stresses the need to intensify therapeutic PD research and points out reasons why the translation of basic research to disease-modifying therapies has been unsuccessful so far. This article is part of a special issue on Parkinson disease. © 2016 International Society for Neurochemistry.

Comparison of experimental and theoretical reaction rail currents, rail voltages, and airgap fields for the linear induction motor research vehicle

NASA Technical Reports Server (NTRS)

Elliott, D. G.

1977-01-01

Measurements of reaction rail currents, reaction rail voltages, and airgap magnetic fields in tests of the Linear Induction Motor Research Vehicle (LIMRV) were compared with theoretical calculations from the mesh/matrix theory. It was found that the rail currents and magnetic fields predicted by the theory are within 20 percent of the measured currents and fields at most motor locations in most of the runs, but differ by as much as a factor of two in some cases. The most consistent difference is a higher experimental than theoretical magnetic field near the entrance of the motor and a lower experimental than theoretical magnetic field near the exit. The observed differences between the theoretical and experimental magnetic fields and currents do not account for the differences of as much as 26 percent between the theoretical and experimental thrusts.

Current Trends of Blanket Research and Deveopment in Japan 4.Blanket Technology Development Using ITER for Demonstration and Commercial Fusion Power Plant

NASA Astrophysics Data System (ADS)

Akiba, Masato; Jitsukawa, Shiroh; Muroga, Takeo

This paper describes the status of blanket technology and material development for fusion power demonstration plants and commercial fusion plants. In particular, the ITER Test Blanket Module, IFMIF, JAERI/DOE HFIR and JUPITER-II projects are highlighted, which have the important role to develop these technology. The ITER Test Blanket Module project has been conducted to demonstrate tritium breeding and power generation using test blanket modules, which will be installed into the ITER facility. For structural material development, the present research status is overviewed on reduced activation ferritic steel, vanadium alloys, and SiC/SiC composites.

Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

NASA Astrophysics Data System (ADS)

van Dyke, Melissa

2004-02-01

Through hardware based design and testing, the EFF-TF investigates fission power and propulsion component, subsystems, and integrated system design and performance. Through demonstration of systems concepts (designed by Sandia and Los Alamos National Laboratories) in relevant environments, previous non-nuclear tests in the EFF-TF have proven to be a highly effective method (from both cost and performance standpoint) to identify and resolve integration issues. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. This paper describes the current efforts for 2003.

Targeted Therapy for Breast Cancer Prevention

PubMed Central

den Hollander, Petra; Savage, Michelle I.; Brown, Powel H.

2013-01-01

With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways include the selective ER modulators (tamoxifen, raloxifene, and lasofoxifene) and aromatase inhibitors (AIs) (anastrozole, letrozole, and exemestane) have been tested in preclinical and clinical studies. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer and promising results of AIs in breast cancer trials, suggest that AIs might be even more effective in the prevention of ER-positive breast cancer. However, these agents only prevent ER-positive breast cancer. Therefore, current research is focused on identifying preventive therapies for other forms of breast cancer such as human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC, breast cancer that does express ER, progesterone receptor, or HER2). HER2-positive breast cancers are currently treated with anti-HER2 therapies including trastuzumab and lapatinib, and preclinical and clinical studies are now being conducted to test these drugs for the prevention of HER2-positive breast cancers. Several promising agents currently being tested in cancer prevention trials for the prevention of TNBC include poly(ADP-ribose) polymerase inhibitors, vitamin D, and rexinoids, both of which activate nuclear hormone receptors (the vitamin D and retinoid X receptors). This review discusses currently used breast cancer preventive drugs, and describes the progress of research striving to identify and develop more effective preventive agents for all forms of breast cancer. PMID:24069582

Testing the Auroral Current-Voltage Relation in Multiple Arcs

NASA Astrophysics Data System (ADS)

Cameron, T. G.; Knudsen, D. J.; Cully, C. M.

2013-12-01

The well-known current-voltage relation within auroral inverted-V regions [Knight, Planet. Space Sci., 21, 741, 1973] predicts current carried by an auroral flux tube given the total potential drop between a plasma-sheet source region and the ionosphere. Numerous previous studies have tested this relation using spacecraft that traverse auroral arcs at low (ionospheric) or mid altitudes. Typically, the potential drop is estimated at the peak of the inverted-V, and field-aligned current is estimated from magnetometer data; statistical information is then gathered over many arc crossings that occur over a wide range of source conditions. In this study we use electron data from the FAST satellite to examine the current-voltage relation in multiple arc sets, in which the key source parameters (plasma sheet density and temperature) are presumed to be identical. We argue that this approach provides a more sensitive test of the Knight relation, and we seek to explain remaining variability with factors other than source variability. This study is supported by a grant from the Natural Sciences and Engineering Research Council of Canada.

Survey Of Wind Tunnels At Langley Research Center

NASA Technical Reports Server (NTRS)

Bower, Robert E.

1989-01-01

Report presented at AIAA 14th Aerodynamic Testing Conference on current capabilities and planned improvements at NASA Langley Research Center's major wind tunnels. Focuses on 14 major tunnels, 8 unique in world, 3 unique in country. Covers Langley Spin Tunnel. Includes new National Transonic Facility (NTF). Also surveys Langley Unitary Plan Wind Tunnel (UPWT). Addresses resurgence of inexpensive simple-to-operate research tunnels. Predicts no shortage of tools for aerospace researcher and engineer in next decade or two.

HIV Knowledge, Risk Behavior, Stigma, and Their Impact on HIV Testing among Asian American and Pacific Islanders: A Review of Literature.

PubMed

Sen, Soma; Nguyen, Hoang Dung; Kim, So Yung; Aguilar, Jemel

2017-01-02

Asian American and Pacific Islanders (AAPIs) are the fastest growing population in the United States with documented increases in HIV rates. AAPIs are as likely as other racial/ethnic groups to engage in HIV-related risk behaviors, while being concomitantly less likely to have been HIV tested. Testing is a critical step in HIV prevention. Research points to various barriers to HIV-related testing including HIV knowledge and attitude and stigma. However, these factors and their impact among AAPIs are poorly understood. Myths about this population's "model minority" status compound AAPIs' sociocultural factors including English language proficiency, access to healthcare, and a culture of "silence" that negatively influences HIV-related research. In this article, the authors review the scientific literature on knowledge, risk behavior, and stigma to document the current state of research. Based on the review the authors offer a set of research, policy, and practice recommendations for social workers and other service providers working with AAPIs.

The Effects of the Activities of Current Textbook and 5 E Model on the Attitude of the Students: Sample of "The Global Effects of Natural Resources Unit"

ERIC Educational Resources Information Center

Uzunoz, Abdulkadir

2011-01-01

This study aimed to determine the effects of the activities of current textbook and 5 E Model on the attitude of the students. This study is a research as an experimental model. For testing the effects of geography education supported by 5 E model and geography education based on activities of current textbook attitude of students, controlled…

A Note on Testing Mediated Effects in Structural Equation Models: Reconciling Past and Current Research on the Performance of the Test of Joint Significance

ERIC Educational Resources Information Center

Valente, Matthew J.; Gonzalez, Oscar; Miocevic, Milica; MacKinnon, David P.

2016-01-01

Methods to assess the significance of mediated effects in education and the social sciences are well studied and fall into two categories: single sample methods and computer-intensive methods. A popular single sample method to detect the significance of the mediated effect is the test of joint significance, and a popular computer-intensive method…

Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death.

PubMed

Al-Khatib, Sana M; Sanders, Gillian D; Bigger, J Thomas; Buxton, Alfred E; Califf, Robert M; Carlson, Mark; Curtis, Anne; Curtis, Jeptha; Fain, Eric; Gersh, Bernard J; Gold, Michael R; Haghighi-Mood, Ali; Hammill, Stephen C; Healey, Jeff; Hlatky, Mark; Hohnloser, Stefan; Kim, Raymond J; Lee, Kerry; Mark, Daniel; Mianulli, Marcus; Mitchell, Brent; Prystowsky, Eric N; Smith, Joseph; Steinhaus, David; Zareba, Wojciech

2007-06-01

Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are of proven predictive value in this population. Efforts in risk stratification for SCD have focused primarily on predicting SCD in patients with known structural heart disease. Despite the ubiquity of tests that have been purported to predict SCD vulnerability in such patients, there is little consensus on which test, in addition to the left ventricular ejection fraction, should be used to determine which patients will benefit from an implantable cardioverter defibrillator. On July 20 and 21, 2006, a group of experts representing clinical cardiology, cardiac electrophysiology, biostatistics, economics, and health policy were joined by representatives of the US Food and Drug administration, Centers for Medicare Services, Agency for Health Research and Quality, the Heart Rhythm Society, and the device and pharmaceutical industry for a round table meeting to review current data on strategies of risk stratification for SCD, to explore methods to translate these strategies into practice and policy, and to identify areas that need to be addressed by future research studies. The meeting was organized by the Duke Center for the Prevention of SCD at the Duke Clinical Research Institute and was funded by industry participants. This article summarizes the presentations and discussions that occurred at that meeting.

Penn State Multi-Discipline Tribology Group and Energy Institute Studies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perez, Joseph

This presentation is a summary of the current research activities on fuels and lubricants in the Multi-discipline Tribology group and the engine test group in the Combustion Laboratory of the Pennsylvania State University. The progress areas discussed in this summary include those found in Table 1. Table 1. RESEARCH AREAS: Diesel Engine Emission Reduction; Oxygenated Fuels; Improved Friction Fuels; Vegetable Oil Lubricants; Extended Drain Lubricants; Effect of Chemical Structure on Friction and Wear. The research is of interest either directly or indirectly to the goal of this workshop, diesel engine emissions reduction. The current projects at Penn State in themore » areas listed above will be discussed.« less

Combat Ready Clamp Addition to the Tactical Combat Casualty Care Guidelines

DTIC Science & Technology

2011-09-23

Combat Gauze™ is currently the onl ( CoTCCC-endorsed intervention for bleeding in areas not amenable to a tourniquet. L Research and anecdotal evidence...them effectively as a battlefield trauma care research , development, test and evaluation (RDT&E) project. 17 In anticipation of this recommendation...the United States Army Medical Research and Materiel Command (USAMRMC) posted a Request for Information (RFI) for devices that could potentially stop

How do students implement collaborative testing in real-world contexts?

PubMed

Wissman, Kathryn T; Rawson, Katherine A

2016-01-01

Recent research has explored the effects of collaborative testing, showing costs and benefits during learning and for subsequent memory. However, no prior research is informative about whether and how students use collaborative testing in real-world contexts. Accordingly, the primary purpose of the current research was to explore the extent to which students use collaborative testing during self-regulated learning. We conducted three surveys (n = 692 across three samples) asking students about their use of collaborative testing, with a particular interest in conditions under which students report implementing collaborative testing. Among the key outcomes, a majority of students reported using collaborative testing when studying in a group. Additionally, students reported that key term definitions are the material most often used during collaborative testing. Students are also more motivated to use testing and believe testing is more effective and more fun when implemented in a group versus alone. Outcomes also shed light on metacognitive components of collaborative testing, with the student asking (versus answering) the question making the monitoring judgement whereas both students make the control decision about when to terminate practice. We discuss ways in which the collaborative memory literature can be extended to support more successful student learning.

They See a Rat, We Seek a Cure for Diseases: The Current Status of Animal Experimentation in Medical Practice

PubMed Central

Kehinde, Elijah O.

2013-01-01

The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. PMID:24217224

They see a rat, we seek a cure for diseases: the current status of animal experimentation in medical practice.

PubMed

Kehinde, Elijah O

2013-01-01

The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. © 2013 S. Karger AG, Basel.

Summary report of the workshop on the U.S. use of surface waves for monitoring the CTBT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ritzwoller, M; Walter, W R

1998-09-01

The workshop addressed the following general research goals of relevance to monitoring and verifying the Comprehensive Test Ban Treaty (CTBT): A) To apprise participants of current and planned research in order to facilitate information exchange, collaboration, and peer review. B) To compare and discuss techniques for data selection, measurement, error assessment, modeling methodologies, etc. To compare results in regions where they overlap and understand the causes of obsenied differences. C) To hear about the U.S. research customer's (AFTAC and DOE Knowledge Base) current and anticipated interests in surface wave research. D) To discuss information flow and integration. How can researchmore » results be prepared for efficient use and integration into operational systems E) To identify and discuss fruitful future directions for research.« less

Effectiveness of diadynamic currents and transcutaneous electrical nerve stimulation in disc disease lumbar part of spine.

PubMed

Ratajczak, Barbara; Hawrylak, Arletta; Demidaś, Aneta; Kuciel-Lewandowska, Jadwiga; Boerner, Ewa

2011-01-01

Back pain has multi-factorial etiology and is modified by environmental influences, character of work, and individual predispositions. The aim of this study was to compare the efficiency of analgesic DD current therapy and TENS in low back discopathy. Eighty patients (age, 45-60 years) with diagnosed low back pain syndrome due to discopathy were subjected to therapy. In the first group (DD) of 40 people, DD current therapy was applied. In the second group (TENS) of 40 people, TENS was applied. The third group of 40 people was a control group in which a functional fitness test was performed for comparison purposes. The control group was in this case an equivalent to a norm. Before the beginning and on the completion of therapy in all patients, a pain level measurement and functional fitness test were performed. On the basis of research conducted it was stated that both therapies reduce pain level effectively. Obtained analyzed results conclude that both therapies applied have an analgesic effect. DD current and TENS therapies in low back discopathy have an analgesic impact and improve functional fitness. The applied therapies have a comparable impact on researched parameters.

Wave-current interactions at the FloWave Ocean Energy Research Facility

NASA Astrophysics Data System (ADS)

Noble, Donald; Davey, Thomas; Steynor, Jeffrey; Bruce, Tom; Smith, Helen; Kaklis, Panagiotis

2015-04-01

Physical scale model testing is an important part of the marine renewable energy development process, allowing the study of forces and device behaviour in a controlled environment prior to deployment at sea. FloWave is a new state-of-the-art ocean energy research facility, designed to provide large scale physical modelling services to the tidal and wave sector. It has the unique ability to provide complex multi-directional waves that can be combined with currents from any direction in the 25m diameter circular tank. The facility is optimised for waves around 2s period and 0.4m height, and is capable of generating currents upwards of 1.6m/s. This offers the ability to model metocean conditions suitable for most renewable energy devices at a typical scale of between 1:10 and 1:40. The test section is 2m deep, which can be classed as intermediate-depth for most waves of interest, thus the full dispersion equation must be solved as the asymptotic simplifications do not apply. The interaction between waves and currents has been studied in the tank. This has involved producing in the tank sets of regular waves, focussed wave groups, and random sea spectra including multi-directional sea states. These waves have been both inline-with and opposing the current, as well as investigating waves at arbitrary angles to the current. Changes in wave height and wavelength have been measured, and compared with theoretical results. Using theoretical wave-current interaction models, methods have been explored to "correct" the wave height in the central test area of the tank when combined with a steady current. This allows the wave height with current to be set equal to that without a current. Thus permitting, for example, direct comparison of device motion response between tests with and without current. Alternatively, this would also permit a specific wave height and current combination to be produced in the tank, reproducing recorded conditions at a particular site of interest. The initial tests used a correction factor based on a linear combination of wave and current (Smith 1997), which was found to be reasonably accurate, although the requirement for higher order theory is also explored. FloWave is a new facility that offers the ability to study wave-current interactions at arbitrary angles with relatively fast currents. This is important as waves and tidal currents at sites of interest for renewable energy generation may not be aligned (Lewis et al. 2014), and so better understanding of these conditions is required. References Lewis, M.J. et al., 2014. Realistic wave conditions and their influence on quantifying the tidal stream energy resource. Applied Energy, 136, pp.495-508. Smith, J.M., 1997. Coastal Engineering Technical Note One-dimensional wave-current interaction (CETN IV-9), Vicksburg, MS.

Development of a Production Ready Automated Wire Delivery System

NASA Technical Reports Server (NTRS)

1997-01-01

The current development effort is a Phase 3 research study entitled "A Production Ready Automated Wire Delivery System", contract number NAS8-39933, awarded to Nichols Research Corporation (NRC). The goals of this research study were to production harden the existing Automated Wire Delivery (AWDS) motion and sensor hardware and test the modified AWDS in a range of welding applications. In addition, the prototype AWDS controller would be moved to the VME bus platform by designing, fabricating and testing a single board VME bus AWDS controller. This effort was to provide an AWDS that could transition from the laboratory environment to production operations. The project was performed in two development steps. Step 1 modified and tested an improved MWG. Step 2 developed and tested the AWDS single board VME bus controller. Step 3 installed the Wire Pilot in a Weld Controller with the imbedded VME bus controller.

Preliminary research on eddy current bobbin quantitative test for heat exchange tube in nuclear power plant

NASA Astrophysics Data System (ADS)

Qi, Pan; Shao, Wenbin; Liao, Shusheng

2016-02-01

For quantitative defects detection research on heat transfer tube in nuclear power plants (NPP), two parts of work are carried out based on the crack as the main research objects. (1) Production optimization of calibration tube. Firstly, ASME, RSEM and homemade crack calibration tubes are applied to quantitatively analyze the defects depth on other designed crack test tubes, and then the judgment with quantitative results under crack calibration tube with more accuracy is given. Base on that, weight analysis of influence factors for crack depth quantitative test such as crack orientation, length, volume and so on can be undertaken, which will optimize manufacture technology of calibration tubes. (2) Quantitative optimization of crack depth. Neural network model with multi-calibration curve adopted to optimize natural crack test depth generated in in-service tubes shows preliminary ability to improve quantitative accuracy.

College Students' Conceptions of Stem Cells, Stem Cell Research, and Cloning

NASA Astrophysics Data System (ADS)

Concannon, James P.; Siegel, Marcelle A.; Halverson, Kristy; Freyermuth, Sharyn

2010-04-01

In this study, we examined 96 undergraduate non-science majors' conceptions of stem cells, stem cell research, and cloning. This study was performed at a large, Midwest, research extensive university. Participants in the study were asked to answer 23 questions relating to stem cells, stem cell research, and cloning in an on-line assessment before and after instruction. Two goals of the instruction were to: (1) help students construct accurate scientific ideas, and (2) enhance their reasoning about socioscientific issues. The course structure included interactive lectures, case discussions, hands-on activities, and independent projects. Overall, students' understandings of stem cells, stem cell research, and cloning increased from pre-test to post-test. For example, on the post-test, students gained knowledge concerning the age of an organism related to the type of stem cell it possesses. However, we found that some incorrect ideas that were evident on the pre-test persisted after instruction. For example, before and after instruction several students maintained the idea that stem cells can currently be used to produce organs.

Electric Vehicles near the Hangar at the Lewis Research Center

NASA Image and Video Library

1977-06-21

The National Aeronautics and Space Administration (NASA) Lewis Research Center tested 16 commercially-manufactured electric vehicles, including these, during the mid-1970s. Lewis and the Energy Research and Development Administration (ERDA) engaged in several energy-related programs in the mid-1970s, including the Electric Vehicle Project. NASA and ERDA undertook the program in 1976 to determine the state of the current electric vehicle technology. The tests were primarily conducted on a 7.5-mile track at the Transportation Research Center located approximately 160 miles southwest of Cleveland, Ohio. Some of the vehicles had analog data recording systems to measure the battery during operation and sensors to determine speed and distance. The tests analyzed the vehicle’s range, acceleration, coast-down, braking, and energy consumption. From left to right: RIPP-Electric, EVA Contactor, Otis P-500, C.H. Waterman DAF, Zagato Elcar, unknown, Sebring-Vanguard Citicar, and Hattronic Minivan

Whatever Works: A Test of the "Division of Labor" Component of Uses and Gratifications Theory.

ERIC Educational Resources Information Center

Carvalho, John

The 1974 book, "The Uses of Mass Communication: Current Perspectives on Gratifications Research" introduced the concept of a "division of labor"--that certain media work better than others in meeting audience gratifications. Since the division of labor concept has not been subjected to empirical testing, a study elaborated an…

A Needs-Based Approach to the Development of a Diagnostic College English Speaking Test

ERIC Educational Resources Information Center

Zhao, Zhongbao

2014-01-01

This paper investigated the current situation of oral English teaching, learning, and assessment at the tertiary level in China through needs analysis and explored the implications for the development of a diagnostic speaking test. Through random sampling, the researcher administered both a student questionnaire and a teacher questionnaire to over…

Genetic variance and covariance components for feed intake, average daily gain, and postweaning gain in growing beef cattle

USDA-ARS?s Scientific Manuscript database

Feed is the single most expensive cost related to a beef cattle production enterprise. Data collection to determine feed efficient animals is also costly. Currently a 70 d performance test is recommended for accurate calculation of efficiency. Previous research has suggested intake tests can be l...

A Confirmatory Factor Analysis of the Life Orientation Test-Revised with Competitive Athletes

ERIC Educational Resources Information Center

Appaneal, Renee N.

2012-01-01

Current reviews outside of sport indicate that the Life Orientation Test-Revised (LOT-R) items load on two separate factors (optimism and pessimism) and, therefore, should be treated as independent constructs. However, researchers in the sport sciences continue to use the single composite score reflecting a unidimensional definition of optimism.…

The Common Sense Guide to the Common Core: Teacher-Tested Tools for Implementation

ERIC Educational Resources Information Center

McKnight, Katherine

2014-01-01

Based on the original source document for the Common Core State Standards and tested by 1,000 educators in diverse classrooms across the country, these research-based tools will help readers examine their current practices and adapt existing curriculum. Each of the 40 tools is clearly presented, explained, and exemplified, guiding educators…

76 FR 28990 - Ultra High Throughput Sequencing for Clinical Diagnostic Applications-Approaches To Assess...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-19

...: 900). If you have never attended a Connect Pro meeting before, test your connection at: https://collaboration.fda.gov/common/help/en/support/meeting_test.htm . To get a quick overview of the Connect Pro... technologies are currently extensively used in research and are entering clinical diagnostic use; they are...

Preliminary eddy current modelling for the large angle magnetic suspension test fixture

NASA Technical Reports Server (NTRS)

Britcher, Colin

1994-01-01

This report presents some recent developments in the mathematical modeling of the Large Angle Magnetic Suspension Test Fixture (LAMSTF) at NASA Langley Research Center. It is shown that these effects are significant, but may be amenable to analysis, modeling and measurement. A theoretical framework is presented, together with a comparison of computed and experimental data.

Accession Medical Standards Analysis and Research Activity (AMSARA)

DTIC Science & Technology

2004-01-01

young adults with psychiatric disorders 15. SUBJECT TERMS Accession, medical, standards, attrition, waiver, discharge, hospitalization, disability...86 Research to Develop a Screening Test for Detection of Psychiatric Disorders in Young Adults ...secondary to organic or functional mental disorders that interfere with work or school after age 12 or current use of medication to improve or maintain

Research and Evaluation Agenda 1993-94 for AISD 1993-94.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

The research and evaluation agenda for the Austin Independent School District (AISD) (Texas) is determined for each school year, subject to current needs and requests. The evaluations and other major projects for 1993-94 will focus on three major areas. First is providing school support. Testing programs mandated by state law and district policy…

Developing Initiatives for Home-Based Child Care: Current Research and Future Directions

ERIC Educational Resources Information Center

Porter, Toni; Paulsell, Diane

2011-01-01

Home-based child care accounts for a significant share of the child care supply in the United States, especially for infants and toddlers. A synthesis of the home-based care research literature and information about recent home-based care quality initiatives points to a critical need for more systematic efforts to develop and test quality…

How Effective Is the Research and Development Ecosystem for England's Schools?

ERIC Educational Resources Information Center

Godfrey, David; Brown, Chris

2018-01-01

This article examines the role of research and development within England's school system. From a range of literature past and present we argue that six features (three dimensions) should form the focus for action at the institutional, systemic and policy levels. Applying these stress tests to the current system, we suggest that an effective…

Development of a Work Control System for Propulsion Testing at Stennis Space Center (SSC)

NASA Technical Reports Server (NTRS)

Messer, Elizabeth A.

2004-01-01

In 1996, Stennis Space Center was given management authority for all Propulsion Testing for NASA. Over the next few years several research and development (R&D) test facilities were completed and brought up to full operation in what is known as the E-Complex Test Facility at Stennis Space Center. This paper will explain the requirements and steps taken to develop the current Test Operations' electronic work control system. The Work Control System developed includes work authorization documents such as test preparation sheets, discrepancy reports, pre-test briefing reports, and test requests.

Aporrectodea caliginosa, a relevant earthworm species for a posteriori pesticide risk assessment: current knowledge and recommendations for culture and experimental design.

PubMed

Bart, Sylvain; Amossé, Joël; Lowe, Christopher N; Mougin, Christian; Péry, Alexandre R R; Pelosi, Céline

2018-06-21

Ecotoxicological tests with earthworms are widely used and are mandatory for the risk assessment of pesticides prior to registration and commercial use. The current model species for standardized tests is Eisenia fetida or Eisenia andrei. However, these species are absent from agricultural soils and often less sensitive to pesticides than other earthworm species found in mineral soils. To move towards a better assessment of pesticide effects on non-target organisms, there is a need to perform a posteriori tests using relevant species. The endogeic species Aporrectodea caliginosa (Savigny, 1826) is representative of cultivated fields in temperate regions and is suggested as a relevant model test species. After providing information on its taxonomy, biology, and ecology, we reviewed current knowledge concerning its sensitivity towards pesticides. Moreover, we highlighted research gaps and promising perspectives. Finally, advice and recommendations are given for the establishment of laboratory cultures and experiments using this soil-dwelling earthworm species.

Two-Speed Gearbox Dynamic Simulation Predictions and Test Validation

NASA Technical Reports Server (NTRS)

Lewicki, David G.; DeSmidt, Hans; Smith, Edward C.; Bauman, Steven W.

2010-01-01

Dynamic simulations and experimental validation tests were performed on a two-stage, two-speed gearbox as part of the drive system research activities of the NASA Fundamental Aeronautics Subsonics Rotary Wing Project. The gearbox was driven by two electromagnetic motors and had two electromagnetic, multi-disk clutches to control output speed. A dynamic model of the system was created which included a direct current electric motor with proportional-integral-derivative (PID) speed control, a two-speed gearbox with dual electromagnetically actuated clutches, and an eddy current dynamometer. A six degree-of-freedom model of the gearbox accounted for the system torsional dynamics and included gear, clutch, shaft, and load inertias as well as shaft flexibilities and a dry clutch stick-slip friction model. Experimental validation tests were performed on the gearbox in the NASA Glenn gear noise test facility. Gearbox output speed and torque as well as drive motor speed and current were compared to those from the analytical predictions. The experiments correlate very well with the predictions, thus validating the dynamic simulation methodologies.

Modern Advances in Genetic Testing: Ethical Challenges and Training Implications for Current and Future Psychologists

PubMed Central

Richmond-Rakerd, Leah S.

2014-01-01

The ethical implications for psychological practice of genetic testing are largely unexplored. Predictive testing can have a significant impact on health and well-being, and increasing numbers of individuals with knowledge of their risk for various disorders are likely to present for psychotherapy. In addition, more people will struggle with the decision of whether to obtain information regarding their genetic material. Psychologists will need to have the appropriate knowledge and clinical skills to effectively counsel this population. This article highlights the relevant ethical issues surrounding psychological treatment of individuals pursuing or considering undergoing genetic testing. These issues are extended to psychologists working in research, education, and policy domains. Recommendations for graduate training programs to facilitate current and future practitioner competence are also discussed. PMID:24707160

X-56A MUTT: Aeroservoelastic Modeling

NASA Technical Reports Server (NTRS)

Ouellette, Jeffrey A.

2015-01-01

For the NASA X-56a Program, Armstrong Flight Research Center has been developing a set of linear states space models that integrate the flight dynamics and structural dynamics. These high order models are needed for the control design, control evaluation, and test input design. The current focus has been on developing stiff wing models to validate the current modeling approach. The extension of the modeling approach to the flexible wings requires only a change in the structural model. Individual subsystems models (actuators, inertial properties, etc.) have been validated by component level ground tests. Closed loop simulation of maneuvers designed to validate the flight dynamics of these models correlates very well flight test data. The open loop structural dynamics are also shown to correlate well to the flight test data.

Exploring the validity of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) with established emotions measures.

PubMed

Roberts, Richard D; Schulze, Ralf; O'Brien, Kristin; MacCann, Carolyn; Reid, John; Maul, Andy

2006-11-01

Emotions measures represent an important means of obtaining construct validity evidence for emotional intelligence (EI) tests because they have the same theoretical underpinnings. Additionally, the extent to which both emotions and EI measures relate to intelligence is poorly understood. The current study was designed to address these issues. Participants (N = 138) completed the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT), two emotions measures, as well as four intelligence tests. Results provide mixed support for the model hypothesized to underlie the MSCEIT, with emotions research and EI measures failing to load on the same factor. The emotions measures loaded on the same factor as intelligence measures. The validity of certain EI components (in particular, Emotion Perception), as currently assessed, appears equivocal. Copyright 2006 APA, all rights reserved.

Research activities at the Loma Linda University and Proton Treatment Facility--an overview

NASA Technical Reports Server (NTRS)

Nelson, G. A.; Green, L. M.; Gridley, D. S.; Archambeau, J. O.; Slater, J. M.

2001-01-01

The Loma Linda University (LLU) Radiobiology Program coordinates basic research and proton beam service activities for the university and extramural communities. The current focus of the program is on the biological and physical properties of protons and the operation of radiobiology facilities for NASA-sponsored projects. The current accelerator, supporting facilities and operations are described along with a brief review of extramural research projects supported by the program. These include space craft electronic parts and shielding testing as well as tumorigenesis and animal behavior experiments. An overview of research projects currently underway at LLU is also described. These include: 1) acute responses of the C57Bl/6 mouse immune system, 2) modulation of gene expression in the nematode C. elegans and rat thyroid cells, 3) quantitation of dose tolerance in rat CNS microvasculature, 4) behavioral screening of whole body proton and iron ion-irradiated C57Bl/6 mice, and 5) investigation of the role of cell integration into epithelial structures on responses to radiation.

Fluctuation between grandiose and vulnerable narcissism.

PubMed

Gore, Whitney L; Widiger, Thomas A

2016-10-01

Current literature on narcissistic personality disorder has emphasized a distinction between grandiose and vulnerable narcissism. Some researchers have further suggested that narcissistic persons fluctuate between grandiose and vulnerable narcissism. However, this perception has been confined largely to clinical experience with no systematic research testing the hypothesis. Clinicians and clinical psychology professors in the current study identified 143 persons who fit a description of either a grandiose or a vulnerable narcissist and indicated the extent to which these persons ever demonstrated traits of the complementary variant. The results supported the fluctuation hypothesis, particularly for episodes of vulnerable narcissism in persons identified as a grandiose narcissist. Correlations of the grandiose and vulnerable narcissism traits with a brief five-factor model measure corroborated past trait descriptions of the 2 respective variants of narcissism. The results of the current study are compared with existing cross-sectional and longitudinal research, and suggestions for future research are provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Fuel-Flexible Engines for Portable-Power Applications

DTIC Science & Technology

2009-05-31

military grade, JP8, respectively. Repeated testing procedures elucidated the need for better measurement and control of the glow plug intensity ...different fuels that are currently available for market consumption. While petroleum- based fuels are being tested in this research, the researchers are...0.8 210 15 TA4, TA7 Gasoline C8-H18 0.75 280 15.1 TA7 Light Diesel C8-H18 0.85 210 15 TA7 Medium Diesel C14-H30 0.85 210 15 TA7 Heavy Diesel C21-H44

AiResearch QCGAT engine: Acoustic test results

NASA Technical Reports Server (NTRS)

Kisner, L. S.

1980-01-01

The noise levels of the quiet, general aviation turbofan (QCGAT) engine were measured in ground static noise tests. The static noise levels were found to be markedly lower than the demonstrably quiet AiResearch model TFE731 engine. The measured QCGAT noise levels were correlated with analytical noise source predictions to derive free-field component noise predictions. These component noise sources were used to predict the QCGAT flyover noise levels at FAR Part 36 conditions. The predicted flyover noise levels are about 10 decibels lower than the current quietest business jets.

Improving the Efficiency and Durability of Reversible Solid Oxide Cells for Energy Storage

NASA Astrophysics Data System (ADS)

Hughes, Gareth Allen

This thesis presents research on the use of solid oxide cells (SOCs) as energy storage devices, and covers methods to improve their efficiency and durability for this use. It specifically covers two main topics: the durability of the oxygen electrode under forced alternating current, and the effect of pressurization on various oxygen electrode materials. Additionally, research was completed on thermodynamic modeling of a pressurized SOC energy storage system, and a new experimental testing apparatus was constructed to enable investigation of SOC samples operating under pressure. Forced alternating current using a symmetric sample structure was used to simulate the operation of a reversible SOC, effectively isolating the measurement of the performance response of the oxygen electrode. Cells consisting of La 0.8Sr0.2MnO3-delta - 8mol% Y2O 3-stabilized ZrO2 (LSM-YSZ) oxygen electrodes on YSZ electrolytes were tested. Early testing utilizing Ag current collectors showed that forced currents and the elevated operating temperature of SOCs cause silver to vaporize and deposit at the active region of the electrode. To avoid this artifact, a new test setup utilizing LSM current collectors was created. It was found that a shorter current cycling time of 1 hour helps prevent degradation compared to 12 hour cycles. Additionally, both cycling times showed improvement compared cells operated with dc current. Further study showed that operating at current densities of 0.8 A/cm2 and below can prevent degradation entirely. Pressurization of oxygen electrodes showed, as expected, that polarization resistance decreases with increasing oxygen pressure. The materials tested were LSM-YSZ and La0.6Sr0.4Fe0.8Co0.2 O3-d - Ce0.8Gd0.2O1.95 (LSCF-GDC), both in single-phase and composite electrode structures. Additionally, LSM-infiltrated YSZ was tested. The resistance typically decreased following power-law behavior with exponents ranging from -0.17 to -0.30, with similar trends found in all material systems and electrode structures. The electrodes showed resistance decreases of factors between 1.4 and 3.5 on going from 0.1 atm O2 to 10 atm O2. The electrodes containing LSM each showed distinct features in their frequency responses and capacitances, while the two LSCF containing electrode showed very similar features. The resistance decreases were attributed to decreased charge transfer reaction limitations and accelerated adsorption and surface migration of oxygen ions.

The effectiveness of cognitive-behavioral group therapy training on improving emotional intelligence and general health of adolescents.

PubMed

Aghel Masjedi, M; Taghavizadeh, M; Azadi, N; Hosseinzadeh, F; Koushkestani, A

2015-01-01

Introduction: The aim of the current research was to examine the effectiveness of cognitive-behavioral group therapy (CBT) training on the general health and improve the emotional intelligence of male adolescents in Tehran city. Methodology: The current research is a semi-trial research with pretest-posttest experimental design and two test and control groups, which were carried out in the 2014-2015 academic year. 40 high school male students were chosen via proper sampling approach and they were stochastically classified into test and control team (each team, n = 20). The students were protested via Baron emotional intelligence and GHQ-28 general health questionnaire. Subsequently, the test group was trained in the cognitive-behavioral group therapy for eight sessions and the control group received no interventions. In the end, both groups were post-tested, and the data were investigated by using a multivariate investigation of covariance method and SPSS-20. Findings: The outcomes demonstrated that there were notable distinctions between the experiment and the checking teams after the implementation of the CBT training (P < 0.001) so that the average score of emotional intelligence and general health increased in test group rather than in the check team. Conclusion: The findings indicated that the CBT practice is useful in improving emotional intelligence and general health in adolescent male students. Thus, one can recommend that appropriate therapy training could be designed to improve their emotional intelligence and general health.

An overview of the Defence Research Agency photovoltaic programme

NASA Technical Reports Server (NTRS)

Goodbody, C.; Davies, M. A. H.

1993-01-01

The Defense Research Agency (DRA) has been active in the photovoltaic field since the early 1960's, then as the Royal Aircraft Establishment (RAE). The early work was aimed at developing silicon cells, solar panels, and light-weight flexible arrays in support of the 'UK' and 'X' series of British scientific and technology satellites, for which the RAE was either the design authority or technical advisor. The X3 satellite - Prospero, launched in 1971 test flew 50 micron wrap-round silicon cells. The X4 satellite - Miranda, launched in 1974 test flew a deployable flexible silicon array which was developed at the DRA. During this period an extensive range of test equipment was developed which was maintained, modernized, and extended to date. Following a period of reduced activity in the late 1970's and early 1980's the current program evolved. The programs that have been undertaken since 1983 are briefly summarized. These range from various cell developments, new types of coverglasses, flight experiments, radiation testing, primary cell calibration, and environmental testing. The current photovoltaic program is mainly funded by the UK Ministry of Defence and by the Department of Trade and Industry through the British National Space Center (BNSC). The program is aimed at research and development, both internally and with industry, to meet the customer's technical objectives and requirements and to provide them with technical advice. The facilities are also being used on contract work for various national and international organizations.

The effectiveness of cognitive-behavioral group therapy training on improving emotional intelligence and general health of adolescents

PubMed Central

Aghel Masjedi, M; Taghavizadeh, M; Azadi, N; Hosseinzadeh, F; Koushkestani, A

2015-01-01

Introduction: The aim of the current research was to examine the effectiveness of cognitive-behavioral group therapy (CBT) training on the general health and improve the emotional intelligence of male adolescents in Tehran city. Methodology: The current research is a semi-trial research with pretest-posttest experimental design and two test and control groups, which were carried out in the 2014-2015 academic year. 40 high school male students were chosen via proper sampling approach and they were stochastically classified into test and control team (each team, n = 20). The students were protested via Baron emotional intelligence and GHQ-28 general health questionnaire. Subsequently, the test group was trained in the cognitive-behavioral group therapy for eight sessions and the control group received no interventions. In the end, both groups were post-tested, and the data were investigated by using a multivariate investigation of covariance method and SPSS-20. Findings: The outcomes demonstrated that there were notable distinctions between the experiment and the checking teams after the implementation of the CBT training (P < 0.001) so that the average score of emotional intelligence and general health increased in test group rather than in the check team. Conclusion: The findings indicated that the CBT practice is useful in improving emotional intelligence and general health in adolescent male students. Thus, one can recommend that appropriate therapy training could be designed to improve their emotional intelligence and general health. PMID:28316719

Commentary: Leveraging discovery science to advance child and adolescent psychiatric research--a commentary on Zhao and Castellanos 2016.

PubMed

Mennes, Maarten

2016-03-01

'Big Data' and 'Population Imaging' are becoming integral parts of inspiring research aimed at delineating the biological underpinnings of psychiatric disorders. The scientific strategies currently associated with big data and population imaging are typically embedded in so-called discovery science, thereby pointing to the hypothesis-generating rather than hypothesis-testing nature of discovery science. In this issue, Yihong Zhao and F. Xavier Castellanos provide a compelling overview of strategies for discovery science aimed at progressing our understanding of neuropsychiatric disorders. In particular, they focus on efforts in genetic and neuroimaging research, which, together with extended behavioural testing, form the main pillars of psychopathology research. © 2016 Association for Child and Adolescent Mental Health.

Genetic testing for exercise prescription and injury prevention: AIS-Athlome consortium-FIMS joint statement.

PubMed

Vlahovich, Nicole; Hughes, David C; Griffiths, Lyn R; Wang, Guan; Pitsiladis, Yannis P; Pigozzi, Fabio; Bachl, Nobert; Eynon, Nir

2017-11-14

There has been considerable growth in basic knowledge and understanding of how genes are influencing response to exercise training and predisposition to injuries and chronic diseases. On the basis of this knowledge, clinical genetic tests may in the future allow the personalisation and optimisation of physical activity, thus providing an avenue for increased efficiency of exercise prescription for health and disease. This review provides an overview of the current status of genetic testing for the purposes of exercise prescription and injury prevention. As such there are a variety of potential uses for genetic testing, including identification of risks associated with participation in sport and understanding individual response to particular types of exercise. However, there are many challenges remaining before genetic testing has evidence-based practical applications; including adoption of international standards for genomics research, as well as resistance against the agendas driven by direct-to-consumer genetic testing companies. Here we propose a way forward to develop an evidence-based approach to support genetic testing for exercise prescription and injury prevention. Based on current knowledge, there is no current clinical application for genetic testing in the area of exercise prescription and injury prevention, however the necessary steps are outlined for the development of evidence-based clinical applications involving genetic testing.

Development and testing of a 180-volt dc electronic circuit breaker with a 335-ampere carry and 1200-ampere interrupt rating

NASA Technical Reports Server (NTRS)

Brush, A. S.; Phillips, R. L.

1991-01-01

NASA Lewis Research Center and associated contractors have conducted a program to assess the potential requirements for a high-current switch to conceptually design a switch using the best existing technology, and to build and demonstrate a breadboard which meets the requirements. The result is the high current remote bus isolator (HRBI). The HRBI is rated at 180 V dc, 335 A continuous with a 1200 A interrupt rating. It also incorporates remote-control and protective features called for by the Space Station Freedom PMAD dc test bed design. Two breadboard 335 A circuit breakers were built and tested that demonstrate a promising concept of paralleled current-limiting modules. The units incorporated all control and protective features required by advanced aerospace power systems. Component stresses in each unit were determined by design, and are consistent with a life of many thousands of fault operations.

Humane Society International's global campaign to end animal testing.

PubMed

Seidle, Troy

2013-12-01

The Research & Toxicology Department of Humane Society International (HSI) operates a multifaceted and science-driven global programme aimed at ending the use of animals in toxicity testing and research. The key strategic objectives include: a) ending cosmetics animal testing worldwide, via the multinational Be Cruelty-Free campaign; b) achieving near-term reductions in animal testing requirements through revision of product sector regulations; and c) advancing humane science by exposing failing animal models of human disease and shifting science funding toward human biology-based research and testing tools fit for the 21st century. HSI was instrumental in ensuring the implementation of the March 2013 European sales ban for newly animal-tested cosmetics, in achieving the June 2013 cosmetics animal testing ban in India as well as major cosmetics regulatory policy shifts in China and South Korea, and in securing precedent-setting reductions in in vivo data requirements for pesticides in the EU through the revision of biocides and plant protection product regulations, among others. HSI is currently working to export these life-saving measures to more than a dozen industrial and emerging economies. 2013 FRAME.

Research of Steel-dielectric Transition Using Subminiature Eddy-current Transducer

NASA Astrophysics Data System (ADS)

Dmitriev, S. F.; Malikov, V. N.; Sagalakov, A. M.; Ishkov, A. V.

2018-05-01

The research aims to develop a subminiature transducer for electrical steel investigation. The authors determined the capability to study steel characteristics at different depths based on variations of eddy-current transducer amplitude at the steel-dielectric boundary. A subminiature transformer-type transducer was designed, which enables to perform local investigations of ferromagnetic materials using an eddy-current method based on local studies of the steel electrical conductivity. Having the designed transducer as a basis, a hardware-software complex was built to perform experimental studies of steel at the interface boundary. Test results are reported for a specimen with continuous and discrete measurements taken at different frequencies. The article provides the key technical information about the eddy current transformer used and describes the methodology of measurements that makes it possible to control steel to dielectric transition.

ISS and STS Commercial Off-the-Shelf Router Testing

NASA Technical Reports Server (NTRS)

Ivancie, William D.; Bell, Terry L.; Shell, Dan

2002-01-01

This report documents the results of testing performed with commercial off-the-shelf (COTS) routers and Internet Protocols (IPs) to determine if COTS equipment and IP could be utilized to upgrade NASA's current Space Transportation System (STS), the Shuttle, and the International Space Station communication infrastructure. Testing was performed by NASA Glenn Research Center (GRC) personnel within the Electronic Systems Test Laboratory (ESTE) with cooperation from the Mission Operations Directorate (MOD) Qualification and Utilization of Electronic System Technology (QUEST) personnel. The ESTE testing occurred between November 1 and 9, 2000. Additional testing was performed at NASA Glenn Research Center in a laboratory environment with equipment configured to emulate the STS. This report documents those tests and includes detailed test procedures, equipment interface requirements, test configurations and test results. The tests showed that a COTS router and standard Transmission Control Protocols and Internet Protocols (TCP/IP) could be used for both the Shuttle and the Space Station if near-error-free radio links are provided.

Novel Damping Concepts for Mechanical Backup Bearings and Passive Magnetically Suspended Rotors

NASA Technical Reports Server (NTRS)

Keith, Theo G., Jr.

2003-01-01

The following summarizes the research accomplished under the titled project. The period of research extended from August 2001 to August 2002. The team of researchers consisted of two Senior Research Associates: Mark Siebert and Carl Buccieri. one PhD student: Pete Kenney and one faculty member: Theo Keith, who was the P.I. Karen Balog was the Program Coordinator. The research was performed at both the NASA Glenn Research Center (GRC) in Cleveland, Ohio and at the University of Toledo. Accordingly, periodic group telephone meetings were held with the team members, the NASA technical coordinators and several other University of Toledo researchers working on-site at GRC. Two passive magnetic bearing test rigs were designed and tested as a result of the work of this NRA. Additionally, two technical papers, based on this effort, were generated and are currently being reviewed.

Hydrogen Infrastructure Testing and Research Facility | Hydrogen and Fuel

Science.gov Websites

stations, enabling NREL to validate current industry standards and methods for hydrogen fueling as well as the HITRF to: Develop, quantify performance of, and improve renewable hydrogen production methods

Automated Road Closure Gate

DOT National Transportation Integrated Search

2000-05-01

This report presents the procedures involved in the research, design, construction, and testing of an Automated Road Closure Gate. The current road closure gates used in South Dakota are often unsafe and difficult to operate. This report will assist ...

In-Space Transportation with Tethers

NASA Technical Reports Server (NTRS)

Lorenzini, Enrico; Estes, Robert D.; Cosmo, Mario L.

1998-01-01

The annual report covers the research conducted on the following topics related to the use of spaceborne tethers for in-space transportation: ProSEDS tether modeling (current collection analyses, influence of a varying tether temperature); proSEDS mission analysis and system dynamics (tether thermal model, thermo-electro-dynamics integrated simulations); proSEDS-tether development and testing (tether requirements, deployment test plan, tether properties testing, deployment tests); and tethers for reboosting the space-based laser (mission analysis, tether system preliminary design, evaluation of attitude constraints).

Combined Quarterly Technical Report Number 23. SATNET Development and Operation. Pluribus Satellite IMP Development. Remote Site Maintenance. Internet Operations and Maintenance. Mobile Access Terminal Network. TCP for the HP3000. TCP-TAC. TCP for VAX-UNIX

DTIC Science & Technology

1981-11-01

evaluate and test these ideas in the Internet research context. 4. Field third-generation gateways. At this point in time, we purposely avoid selecting a...plan to cover the period from now until the time when a gateway system can be fielded which implements the results of the current work in the Internet ... research community. The current gateway system is inadequate from both a functionality and a• performance standpoint, and therefore the transition

The effects of a test-taking strategy intervention for high school students with test anxiety in advanced placement science courses

NASA Astrophysics Data System (ADS)

Markus, Doron J.

Test anxiety is one of the most debilitating and disruptive factors associated with underachievement and failure in schools (Birenbaum, Menucha, Nasser, & Fadia, 1994; Tobias, 1985). Researchers have suggested that interventions that combine multiple test-anxiety reduction techniques are most effective at reducing test anxiety levels (Ergene, 2003). For the current study, involving 62 public high school students enrolled in advanced placement science courses, the researcher designed a multimodal intervention designed to reduce test anxiety. Analyses were conducted to assess the relationships among test anxiety levels, unit examination scores, and irregular multiple-choice error patterns (error clumping), as well as changes in these measures after the intervention. Results indicate significant, positive relationships between some measures of test anxiety and error clumping, as well as significant, negative relationships between test anxiety levels and student achievement. In addition, results show significant decreases in holistic measures of test anxiety among students with low anxiety levels, as well as decreases in Emotionality subscores of test anxiety among students with high levels of test anxiety. There were no significant changes over time in the Worry subscores of test anxiety. Suggestions for further research include further confirmation of the existence of error clumping, and its causal relationship with test anxiety.

Emergency Locator Transmitter Crash Testing

NASA Image and Video Library

2015-07-29

Drop-testing a series of three Cessna 172 aircraft, NASA simulated severe but survivable plane accidents on July 2, July 29 and August 26, 2015, to test emergency locator transmitters (ELTs). A research team equipped the vintage airplanes with five ELTs, two crash test dummies, cameras and data-collecting sensors. ELTs are installed on general aviation and commercial planes to transmit a location signal in the event of a crash. Current ELT models send that signal to orbiting satellites, which repeat it to the nearest search and rescue ground station. The signal is used to determine and transmit the ELT's identity and location to rescuers. ELTs have to work in the extreme circumstances involved in an airplane crash. Included in those extreme circumstances are the possibilities of excessive vibration, fire and impact damage. NASA research is designed to find practical ways to improve ELT system performance and robustness, giving rescue workers the best chance of saving lives. The research was funded by the Search and Rescue Mission Office at NASA's Goddard Space Flight Center in Greenbelt, Maryland. The testing took place at NASA’s Langley Research Center in Hampton, Virginia. This is a video of the July 29, 2015, test.

Study Designs and Statistical Analyses for Biomarker Research

PubMed Central

Gosho, Masahiko; Nagashima, Kengo; Sato, Yasunori

2012-01-01

Biomarkers are becoming increasingly important for streamlining drug discovery and development. In addition, biomarkers are widely expected to be used as a tool for disease diagnosis, personalized medication, and surrogate endpoints in clinical research. In this paper, we highlight several important aspects related to study design and statistical analysis for clinical research incorporating biomarkers. We describe the typical and current study designs for exploring, detecting, and utilizing biomarkers. Furthermore, we introduce statistical issues such as confounding and multiplicity for statistical tests in biomarker research. PMID:23012528

A human factors approach towards the design of a new glovebox glove for Los Alamos National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oka, Jude M.

Present day glovebox gloves at Los Alamos National Laboratory (LANL) are underdeveloped and ergonomically inaccurate. This problem results in numerous sprain and strain injuries every year for employees who perform glovebox work. In addition to injuries, using the current glovebox glove design also contributes to breaches and contamination. The current glove used today at LANL has several problems: (1) The length of the fingers is incorrect, (2) the web spacing between the fingers is nonexistent, (3) the angles between each digit on the finger are incorrect, (4) the thumb is placed inaccurately, and (5) the length of the hand ismore » incorrect. These problems present a need to correct the current glove design to decrease the risk of injuries, breaches, and contamination. Anthropometrics were researched to help find the best range of hand measurements to fix the current glove design. Anthropometrics is the measure of the human physical variation. Anthropometrics for this study were gathered from the American National Survey (ANSUR) data that was conducted by the U.S Army in 1988. The current glovebox glove uses anthropometrics from the 95th to 105th percentile range which is too large so the new gloves are going to implement data from a smaller range of percentile groups. The 105th percentile range represents measurements that exceed the human population but are needed to fit certain circumstance such as wearing several under gloves within the glovebox gloves. Anthropometrics used in this study include: 105th percentile measurements for joint circumference which was unchanged because the room for under gloves plus ease of hand insertion and extraction is needed, 80th percentile measurements for crotch length to allow workers to reach the web spacing in the glove, 20th percentile measurements for finger length to allow workers to reach the end of the glove, standard 10.5cm hand breadth to allow more room to accommodate under gloves, 45 degrees abduction angle for the thumb for better positioning, 45 degrees extension angle for the thumb for better positioning, and various angles for the other fingers to allow a more relaxed and natural fit. 3D modeling was used to implement the anthropometric data listed above onto an existing scanned solid model of a human hand. SolidWorks 2010 3-D modeling package was utilized to manipulate the hand model to represent the anthropometric data researched. The anthropometrics and modifications were reviewed by the University of New Mexico Department of Orthopedics hand surgeons. After all modifications and reviews were completed the model was printed out using stereolithography. The printed out model of the hand was used as a mold to create a prototype glovebox glove. The new mold was taken to Piercan USA to produce a 20mil Polyurethane/Hypalon glovebox glove. The Minnesota Dexterity test and Purdue Pegboard test were used to measure the dexterity of the prototype glovebox glove against a current 15 mil Hypalon LANL glovebox glove. Using the data from the tests a student t test was used to determine if there was a significant difference between the current hypalon glove results and the new prototype glove results. With a 95% confidence level the prototype showed to have a significantly lower mean difference from the current hypalon glovebox glove with the Minnesota Dexterity test. With a 95% confidence level the prototype showed to have a significantly higher mean difference from the current hypalon glovebox glove with the Purdue Pegboard test. A p value method was also performed to confirm the results of the student t test. A survey was also given to glovebox workers to determine if they preferred the new design. The best reaction from glovebox workers was the new thumb position, 73.2% of the sample population agreed with the new thumb position. Developing a new glovebox glove will improve the ergonomics of the hand for work performed, decrease exposure time, decreasing risk of breaching, increasing productivity, reducing injuries, and improving work performance. In the future the new glovebox glove can also be implemented in other research fields such as: pharmaceutical research and development, semiconducting industry, biohazard industry, and other laboratories conducting nuclear research and development.« less

Review: Properties of sperm and seminal fluid, informed by research on reproduction and contraception.

PubMed

Cotton, Robin W; Fisher, Matthew B

2015-09-01

Forensic DNA testing is grounded in molecular biology and population genetics. The technologies that were the basis of restriction length polymorphism testing (RFLP) have given way to PCR based technologies. While PCR has been the pillar of short tandem repeat (STR) methods and will continue to be used as DNA sequencing and analysis of single nucleotide polymorphisms (SNPs) are introduced into human identification, the molecular biology techniques in use today represent significant advances since the introduction of STR testing. Large forensic laboratories with dedicated research teams and forensic laboratories which are part of academic institutions have the resources to keep track of advances which can then be considered for further research or incorporated into current testing methods. However, many laboratories have limited ability to keep up with research advances outside of the immediate area of forensic science and may not have access to a large university library systems. This review focuses on filling this gap with respect to areas of research that intersect with selected methods used in forensic biology. The review summarizes information collected from several areas of the scientific literature where advances in molecular biology have produced information relevant to DNA analysis of sexual assault evidence and methods used in presumptive and confirmatory identification of semen. Older information from the literature is also included where this information may not be commonly known and is relevant to current methods. The topics selected highlight (1) information from applications of proteomics to sperm biology and human reproduction, (2) seminal fluid proteins and prostate cancer diagnostics, (3) developmental biology of sperm from the fertility literature and (4) areas where methods are common to forensic analysis and research in contraceptive use and monitoring. Information and progress made in these areas coincide with the research interests of forensic biology and cross-talk between these disciplines may benefit both. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Laboratory Diagnosis of Zika Virus Infection.

PubMed

Landry, Marie Louise; St George, Kirsten

2017-01-01

-The rapid and accurate diagnosis of Zika virus infection is an international priority. -To review current recommendations, methods, limitations, and priorities for Zika virus testing. -Sources include published literature, public health recommendations, laboratory procedures, and testing experience. -Until recently, the laboratory diagnosis of Zika infection was confined to public health or research laboratories that prepared their own reagents, and test capacity has been limited. Furthermore, Zika cross-reacts serologically with other flaviviruses, such as dengue, West Nile, and yellow fever. Current or past infection, or even vaccination with another flavivirus, will often cause false-positive or uninterpretable Zika serology results. Detection of viral RNA during acute infection using nucleic acid amplification tests provides more specific results, and a number of commercial nucleic acid amplification tests have received emergency use authorization. In addition to serum, testing of whole blood and urine is recommended because of the higher vial loads and longer duration of shedding. However, nucleic acid amplification testing has limited utility because many patients are asymptomatic or present for testing after the brief period of Zika shedding has passed. Thus, the greatest need and most difficult challenge is development of accurate antibody tests for the diagnosis of recent Zika infection. Research is urgently needed to identify Zika virus epitopes that do not cross-react with other flavivirus antigens. New information is emerging at a rapid pace and, with ongoing public-private and international collaborations and government support, it is hoped that rapid progress will be made in developing robust and widely applicable diagnostic tools.

Preclinical animal anxiety research - flaws and prejudices.

PubMed

Ennaceur, Abdelkader; Chazot, Paul L

2016-04-01

The current tests of anxiety in mice and rats used in preclinical research include the elevated plus-maze (EPM) or zero-maze (EZM), the light/dark box (LDB), and the open-field (OF). They are currently very popular, and despite their poor achievements, they continue to exert considerable constraints on the development of novel approaches. Hence, a novel anxiety test needs to be compared with these traditional tests, and assessed against various factors that were identified as a source of their inconsistent and contradictory results. These constraints are very costly, and they are in most cases useless as they originate from flawed methodologies. In the present report, we argue that the EPM or EZM, LDB, and OF do not provide unequivocal measures of anxiety; that there is no evidence of motivation conflict involved in these tests. They can be considered at best, tests of natural preference for unlit and/or enclosed spaces. We also argued that pharmacological validation of a behavioral test is an inappropriate approach; it stems from the confusion of animal models of human behavior with animal models of pathophysiology. A behavioral test is developed to detect not to produce symptoms, and a drug is used to validate an identified physiological target. In order to overcome the major methodological flaws in animal anxiety studies, we proposed an open space anxiety test, a 3D maze, which is described here with highlights of its various advantages over to the traditional tests.

Generation of mechanical vibrations in metal samples by the use of the pinch effect

NASA Astrophysics Data System (ADS)

Troitskiy, O. A.; Skvortsov, O. B.; Stashenko, V. I.

2017-07-01

The article presents the recent research in electrodynamic processes for metal samples exposed to current pulses. The pinch effect and the skin effect cause the vibration of the metal rods. The results of these studies show how current and magnetic field interact with material samples of gold, silver and copper. The analysis allowed establishing the dependences of peak acceleration on current density and conductor diameter. The dependencies can be used in metal workings and for nondestructive testing.

Space shuttle hypergolic bipropellant RCS engine design study, Bell model 8701

NASA Technical Reports Server (NTRS)

1974-01-01

A research program was conducted to define the level of the current technology base for reaction control system rocket engines suitable for space shuttle applications. The project consisted of engine analyses, design, fabrication, and tests. The specific objectives are: (1) extrapolating current engine design experience to design of an RCS engine with required safety, reliability, performance, and operational capability, (2) demonstration of multiple reuse capability, and (3) identification of current design and technology deficiencies and critical areas for future effort.

Smart monitoring system based on adaptive current control for superconducting cable test.

PubMed

Arpaia, Pasquale; Ballarino, Amalia; Daponte, Vincenzo; Montenero, Giuseppe; Svelto, Cesare

2014-12-01

A smart monitoring system for superconducting cable test is proposed with an adaptive current control of a superconducting transformer secondary. The design, based on Fuzzy Gain Scheduling, allows the controller parameters to adapt continuously, and finely, to the working variations arising from transformer nonlinear dynamics. The control system is integrated in a fully digital control loop, with all the related benefits, i.e., high noise rejection, ease of implementation/modification, and so on. In particular, an accurate model of the system, controlled by a Fuzzy Gain Scheduler of the superconducting transformer, was achieved by an experimental campaign through the working domain at several current ramp rates. The model performance was characterized by simulation, under all the main operating conditions, in order to guide the controller design. Finally, the proposed monitoring system was experimentally validated at European Organization for Nuclear Research (CERN) in comparison to the state-of-the-art control system [P. Arpaia, L. Bottura, G. Montenero, and S. Le Naour, "Performance improvement of a measurement station for superconducting cable test," Rev. Sci. Instrum. 83, 095111 (2012)] of the Facility for the Research on Superconducting Cables, achieving a significant performance improvement: a reduction in the system overshoot by 50%, with a related attenuation of the corresponding dynamic residual error (both absolute and RMS) up to 52%.

Genetic toxicology in the 21st century: Reflections and future ...

EPA Pesticide Factsheets

A symposium at the 40th anniversary of the Environmental Mutagen Society, held from October 24–28, 2009 in St. Louis, MO, surveyed the current status and future directions of genetic toxicology. This article summarizes the presentations and provides a perspective on the future. An abbreviated history is presented, highlighting the current standard battery of genotoxicity assays and persistent challenges. Application of computational toxicology to safety testing within a regulatory setting is discussed as a means for reducing the need for animal testing and human clinical trials, and current approaches and applications of in silico genotoxicity screening approaches across the pharmaceutical industry were surveyed and are reported here. The expanded use of toxicogenomics to illuminate mechanisms and bridge genotoxicity and carcinogenicity, and new public efforts to use high-throughput screening technologies to address lack of toxicity evaluation for the backlog of thousands of industrial chemicals in the environment are detailed. The Tox21 project involves coordinated efforts of four U.S. Government regulatory/research entities to use new and innovative assays to characterize key steps in toxicity pathways, including genotoxic and nongenotoxic mechanisms for carcinogenesis. Progress to date, highlighting preliminary test results from the National Toxicology Program is summarized. Finally, an overview is presented of ToxCast™, a related research program of the

Autonomy Community of Interest (COI) Test and Evaluation, Verification and Validation (TEVV) Working Group: Technology Investment Strategy 2015-2018

DTIC Science & Technology

2015-05-01

Evaluation Center of Excellence SUAS Small Unmanned Aircraft System SUT System under Test T&E Test and Evaluation TARDEC Tank Automotive Research...17 Distribution A: Distribution Unlimited 2 Background In the past decade, unmanned systems have significantly impacted warfare...environments at a speed and scale beyond manned capability. However, current unmanned systems operate with minimal autonomy. To meet warfighter needs and

A Multi-Disciplinary University Research Initiative in Hard and Soft Information Fusion: Overview, Research Strategies and Initial Results

DTIC Science & Technology

2010-07-01

Multisource Information Fusion ( CMIF ) along with a team including the Pennsylvania State University (PSU), Iona College (Iona), and Tennessee State...License. 14. ABSTRACT The University at Buffalo (UB) Center for Multisource Information Fusion ( CMIF ) along with a team including the Pennsylvania...of CMIF current research on methods for Test and Evaluation ([7], [8]) involving for example large- factor-space experimental design techniques ([9

Military Relevant Infectious Diseases Endemic to Kenya: Vaccine and Clinical Trials and Entomology

DTIC Science & Technology

2014-04-01

of Research (WRAIR) and its Special Foreign Activity (SFA) the U.S. Army Medical Research Unit Kenya (USAMRU-K). Previous support was provided under...Kisumu and its environs. Current efforts focus on drug sensitivity testing for antimalarials , vaccine trials and field research to determine vector...prophylaxis. Antimalarial drug sensitivity of isolates from defined populations in the region will continue to be monitored and data used to map the

Simulation test beds for the space station electrical power system

NASA Technical Reports Server (NTRS)

Sadler, Gerald G.

1988-01-01

NASA Lewis Research Center and its prime contractor are responsible for developing the electrical power system on the space station. The power system will be controlled by a network of distributed processors. Control software will be verified, validated, and tested in hardware and software test beds. Current plans for the software test bed involve using real time and nonreal time simulations of the power system. This paper will discuss the general simulation objectives and configurations, control architecture, interfaces between simulator and controls, types of tests, and facility configurations.

Recommendations for the treatment of aging in standard technical specifications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orton, R.D.; Allen, R.P.

1995-09-01

As part of the US Nuclear Regulatory Commission`s Nuclear Plant Aging Research Program, Pacific Northwest Laboratory (PNL) evaluated the standard technical specifications for nuclear power plants to determine whether the current surveillance requirements (SRs) were effective in detecting age-related degradation. Nuclear Plant Aging Research findings for selected systems and components were reviewed to identify the stressors and operative aging mechanisms and to evaluate the methods available to detect, differentiate, and trend the resulting aging degradation. Current surveillance and testing requirements for these systems and components were reviewed for their effectiveness in detecting degraded conditions and for potential contributions to prematuremore » degradation. When the current surveillance and testing requirements appeared ineffective in detecting aging degradation or potentially could contribute to premature degradation, a possible deficiency in the SRs was identified that could result in undetected degradation. Based on this evaluation, PNL developed recommendations for inspection, surveillance, trending, and condition monitoring methods to be incorporated in the SRs to better detect age- related degradation of these selected systems and components.« less

Response of Nuclear Power Plant Instrumentation Cables Exposed to Fire Conditions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muna, Alice Baca; LaFleur, Chris Bensdotter; Brooks, Dusty Marie

This report presents the results of instrumentation cable tests sponsored by the US Nuclear Regulatory Commission (NRC) Office of Nuclear Regulatory Research and performed at Sandia National Laboratories (SNL). The goal of the tests was to assess thermal and electrical response behavior under fire-exposure conditions for instrumentation cables and circuits. The test objective was to assess how severe radiant heating conditions surrounding an instrumentation cable affect current or voltage signals in an instrumentation circuit. A total of thirty-nine small-scale tests were conducted. Ten different instrumentation cables were tested, ranging from one conductor to eight-twisted pairs. Because the focus of themore » tests was thermoset (TS) cables, only two of the ten cables had thermoplastic (TP) insulation and jacket material and the remaining eight cables were one of three different TS insulation and jacket material. Two instrumentation cables from previous cable fire testing were included, one TS and one TP. Three test circuits were used to simulate instrumentation circuits present in nuclear power plants: a 4–20 mA current loop, a 10–50 mA current loop and a 1–5 VDC voltage loop. A regression analysis was conducted to determine key variables affecting signal leakage time.« less

Wind Tunnel and Hover Performance Test Results for Multicopter UAS Vehicles

NASA Technical Reports Server (NTRS)

Russell, Carl R.; Jung, Jaewoo; Willink, Gina; Glasner, Brett

2016-01-01

There is currently a lack of published data for the performance of multicopter unmanned aircraft system (UAS) vehicles, such as quadcopters and octocopters, often referred to collectively as drones. With the rapidly increasing popularity of multicopter UAS, there is interest in better characterizing the performance of this type of aircraft. By studying the performance of currently available vehicles, it will be possible to develop models for vehicles at this scale that can accurately predict performance and model trajectories. This paper describes a wind tunnel test that was recently performed in the U.S. Army's 7- by 10-ft Wind Tunnel at NASA Ames Research Center. During this wind tunnel entry, five multicopter UAS vehicles were tested to determine forces and moments as well as electrical power as a function of wind speed, rotor speed, and vehicle attitude. The test is described here in detail, and a selection of the key results from the test is presented.

Perspectives on social media in and as research: A synthetic review.

PubMed

Lafferty, Natalie T; Manca, Annalisa

2015-04-01

With the growth of social media use in both the private and public spheres, researchers are currently exploring the new opportunities and practices offered by these tools in the research lifecycle. This area is still in its infancy: As methodological approaches and methods are being tested - mainly through pragmatic and exploratory approaches - practices are being shaped and negotiated by the actors involved in research. A further element of complexity is added by the ambivalent status of social media within research activities. They can be both a tool - for recruitment, data collection, analysis - and data - as what constitutes the corpus to be analysed - both in an observational and interactive domain. This synthetic analysis of the literature is aimed at identifying how social media are currently being used in research and how they fit into the research lifecycle. We identify and discuss emerging evidence and trends in the adoption of social media in research, which can be used and applied by psychiatry research practitioners as a framework to inform the development of a personalized research network and social media strategy in research.

Drainage identification analysis and mapping, phase 2 : technical brief.

DOT National Transportation Integrated Search

2017-01-01

This research studied, tested and rectified the compatibility issue related to the recent upgrades of : NJDOT vendor inspection software, and uploaded all collected data to make Drainage Identification : Analysis and Mapping System (DIAMS) current an...

Otosclerosis

MedlinePlus

... potential new treatments. NIDCD-supported researchers are currently testing—in animals—the effectiveness of an implantable device that can deliver a bone-growth inhibiting drug directly into the inner ear to correct the ... are promising, testing will later be done in people. Where can ...

Summary of Research 2000: Department of Oceanography

DTIC Science & Technology

2001-12-01

Castro, R., A. S. Mascarenhas, R. Durazo and C. Collins, "Variaci6n estacional de la temperatura y salinidad en la entrada del Golfo de California...AREAS: Sensors , Battlespace Environments KEYWORDS: Littoral, Acoustics, Nowcast, Shelfbreak Fronts NAVAL POSTGRADUATE SCHOOL OAO TEST-BAN TREATY...Organization. DoD KEY TECHNOLOGY AREAS: Sensors KEYWORDS: Nuclear Test-Ban Treaty Monitoring OCEAN ACOUSTIC FEDERATION: CALIFORNIA CURRENT MONITORING

Women and Graduate Management Education. 2015 Data to Go

ERIC Educational Resources Information Center

Graduate Management Admission Council, 2015

2015-01-01

To commemorate International Women's Day on March 8, 2015, GMAC prepared this Data-to-Go brief as a summary of current GMAT test taker and research data about women in the business school pipeline. Findings in this Data-to-Go report are derived from several sources of GMAT test taker data and GMAC surveys conducted in 2014 and 2015. In testing…

Small-Sample DIF Estimation Using Log-Linear Smoothing: A SIBTEST Application. Research Report. ETS RR-07-10

ERIC Educational Resources Information Center

Puhan, Gautam; Moses, Tim P.; Yu, Lei; Dorans, Neil J.

2007-01-01

The purpose of the current study was to examine whether log-linear smoothing of observed score distributions in small samples results in more accurate differential item functioning (DIF) estimates under the simultaneous item bias test (SIBTEST) framework. Data from a teacher certification test were analyzed using White candidates in the reference…

Comparison of Performance on Two Nonverbal Intelligence Tests by Adolescents with and without Language Impairment

ERIC Educational Resources Information Center

Miller, Carol A.; Gilbert, Erin

2008-01-01

Definitions of specific language impairment (SLI), for both research and clinical purposes, often state that nonverbal IQ scores must be within normal limits. This use of nonverbal IQ has been criticized on several grounds, including lack of equivalence between tests. In the current study, a sample of 204 adolescents with and without language…

Preliminary Findings of the PAULEX Project: A Proposal for the Internet-Based Valencian University Entrance Examination

ERIC Educational Resources Information Center

Garcia Laborda, Jesus

2012-01-01

Although there is an increasing number of online tests in the world, little research is currently known in Spain today. Assessment has become an integral part of education and the implications of the various uses of language testing go beyond the educational settings (Douglas, 2010; Fulcher, 2010). This study describes the PAULEX project. This…

Nursing Faculty Decision Making about Best Practices in Test Construction, Item Analysis, and Revision

ERIC Educational Resources Information Center

Killingsworth, Erin Elizabeth

2013-01-01

With the widespread use of classroom exams in nursing education there is a great need for research on current practices in nursing education regarding this form of assessment. The purpose of this study was to explore how nursing faculty members make decisions about using best practices in classroom test construction, item analysis, and revision in…

Advanced Stirling Convertor Testing at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Poriti, Sal

2010-01-01

The NASA Glenn Research Center (GRC) has been testing high-efficiency free-piston Stirling convertors for potential use in radioisotope power systems (RPSs) since 1999. The current effort is in support of the Advanced Stirling Radioisotope Generator (ASRG), which is being developed by the U.S. Department of Energy (DOE), Lockheed Martin Space Systems Company (LMSSC), Sunpower, Inc., and the NASA GRC. This generator would use two high-efficiency Advanced Stirling Convertors (ASCs) to convert thermal energy from a radioisotope heat source into electricity. As reliability is paramount to a RPS capable of providing spacecraft power for potential multi-year missions, GRC provides direct technology support to the ASRG flight project in the areas of reliability, convertor and generator testing, high-temperature materials, structures, modeling and analysis, organics, structural dynamics, electromagnetic interference (EMI), and permanent magnets to reduce risk and enhance reliability of the convertor as this technology transitions toward flight status. Convertor and generator testing is carried out in short- and long-duration tests designed to characterize convertor performance when subjected to environments intended to simulate launch and space conditions. Long duration testing is intended to baseline performance and observe any performance degradation over the life of the test. Testing involves developing support hardware that enables 24/7 unattended operation and data collection. GRC currently has 14 Stirling convertors under unattended extended operation testing, including two operating in the ASRG Engineering Unit (ASRG-EU). Test data and high-temperature support hardware are discussed for ongoing and future ASC tests with emphasis on the ASC-E and ASC-E2.

Photogrammetry and optical methods in structural dynamics - A review

NASA Astrophysics Data System (ADS)

Baqersad, Javad; Poozesh, Peyman; Niezrecki, Christopher; Avitabile, Peter

2017-03-01

In the last few decades, there has been a surge of research in the area of non-contact measurement techniques. Photogrammetry has received considerable attention due to its ability to achieve full-field measurement and its robustness to work in testing environments and on testing articles in which using other measurement techniques may not be practical. More recently, researchers have used this technique to study transient phenomena and to perform measurements on vibrating structures. The current paper reviews the most current trends in the photogrammetry technique (point tracking, digital image correlation, and target-less approaches) and compares the applications of photogrammetry to other measurement techniques used in structural dynamics (e.g. laser Doppler vibrometry and interferometry techniques). The paper does not present the theoretical background of the optical techniques, but instead presents the general principles of each approach and highlights the novel structural dynamic measurement concepts and applications that are enhanced by utilizing optical techniques.

The construction of airfoil pressure models by the plate method: Achievements, current research, technology development and potential applications

NASA Technical Reports Server (NTRS)

Lawing, P. L.

1985-01-01

A method of constructing airfoils by inscribing pressure channels on the face of opposing plates, bonding them together to form one plate with integral channels, and contour machining this plate to form an airfoil model is described. The research and development program to develop the bonding technology is described as well as the construction and testing of an airfoil model. Sample aerodynamic data sets are presented and discussed. Also, work currently under way to produce thin airfoils with camber is presented. Samples of the aft section of a 6 percent airfoil with complete pressure instrumentation including the trailing edge are pictured and described. This technique is particularly useful in fabricating models for transonic cryogenic testing, but it should find application in a wide ange of model construction projects, as well as the fabrication of fuel injectors, space hardware, and other applications requiring advanced bonding technology and intricate fluid passages.

A simulator study for the development and evaluation of operating procedures on a supersonic cruise research transport to minimize airport-community noise

NASA Technical Reports Server (NTRS)

Grantham, W. D.; Smith, P. M.; Deal, P. L.

1980-01-01

Piloted-simulator studies were conducted to determine takeoff and landing operating procedures for a supersonic cruise research transport concept that result in predicted noise levels which meet current Federal Aviation Administration (FAA) certification standards. With the use of standard FAA noise certification test procedures, the subject simulated aircraft did not meet the FAA traded-noise-level standards during takeoff and landing. However, with the use of advanced procedures, this aircraft meets the traded-noise-level standards for flight crews with average skills. The advanced takeoff procedures developed involved violating some of the current Federal Aviation Regulations (FAR), but it was not necessary to violate any FAR noise-test conditions during landing approach. Noise contours were also determined for some of the simulated takeoffs and landings in order to indicate the noise-reduction advantages of using operational procedures other than standard.

NASA Advanced Life Support Technology Testing and Development

NASA Technical Reports Server (NTRS)

Wheeler, Raymond M.

2012-01-01

Prior to 2010, NASA's advanced life support research and development was carried out primarily under the Exploration Life Support Project of NASA's Exploration Systems Mission Directorate. In 2011, the Exploration Life Support Project was merged with other projects covering Fire Prevention/Suppression, Radiation Protection, Advanced Environmental Monitoring and Control, and Thermal Control Systems. This consolidated project was called Life Support and Habitation Systems, which was managed under the Exploration Systems Mission Directorate. In 2012, NASA re-organized major directorates within the agency, which eliminated the Exploration Systems Mission Directorate and created the Office of the Chief Technologist (OCT). Life support research and development is currently conducted within the Office of the Chief Technologist, under the Next Generation Life Support Project, and within the Human Exploration Operation Missions Directorate under several Advanced Exploration System projects. These Advanced Exploration Systems projects include various themes of life support technology testing, including atmospheric management, water management, logistics and waste management, and habitation systems. Food crop testing is currently conducted as part of the Deep Space Habitation (DSH) project within the Advanced Exploration Systems Program. This testing is focused on growing salad crops that could supplement the crew's diet during near term missions.

Environmental-Scale Map Use in Middle Childhood: Links to Spatial Skills, Strategies, and Gender

ERIC Educational Resources Information Center

Liben, Lynn S.; Myers, Lauren J.; Christensen, Adam E.; Bower, Corinne A.

2013-01-01

Researchers have shown that young children solve mapping tasks in small spaces, but have rarely tested children's performance in large, unfamiliar environments. In the current research, children (9-10 years; N = 40) explored an unfamiliar campus and marked flags' locations on a map. As hypothesized, better performance was predicted by…

The Effects of Baby Sign Training on Child Development

ERIC Educational Resources Information Center

Mueller, Vannesa; Sepulveda, Amanda; Rodriguez, Sarai

2014-01-01

Although Baby Sign is gaining in popularity, there is a scarcity of research supporting its use. The research that has been conducted is conflicting. In the current study, nine families with children ranging in age from six months to two years and five months participated in a baby sign workshop. A pre--post-test design was used to assess the…

Drugs and Personality: Personality Correlates and Predictors of Non-Opiate Drug Use. Research Issues 14.

ERIC Educational Resources Information Center

Austin, Gregory A., Ed.; And Others

This collection of abstracts from current research and theoretical studies explores various aspects of the relationship between non-opiate drug use and personality. The literature covers a period from 1968 through 1975 and focuses on tests that were conducted on adolescents and college students from the United States, Canada and Sydney, Australia.…

DOE/DOT Crude Oil Characterization Research Study, Task 2 Test Report on Evaluating Crude Oil Sampling and Analysis Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lord, David; Allen, Ray; Rudeen, David

The Crude Oil Characterization Research Study is designed to evaluate whether crude oils currently transported in North America, including those produced from "tight" formations, exhibit physical or chemical properties that are distinct from conventional crudes, and how these properties associate with combustion hazards with may be realized during transportation and handling.

Extending the 2 x 2 Achievement Goal Framework: Development of a Measure of Scientific Achievement Goals

ERIC Educational Resources Information Center

Deemer, Eric D.; Carter, Alice P.; Lobrano, Michael T.

2010-01-01

The current research sought to extend the 2 x 2 achievement goal framework by developing and testing the Achievement Goals for Research Scale (AGRS). Participants (N = 317) consisted of graduate students in the life, physical, and behavioral sciences. A principal components analysis (PCA) extracted five components accounting for 72.59% of the…

Child ADHD Severity and Positive and Negative Parenting as Predictors of Child Social Functioning: Evaluation of Three Theoretical Models

ERIC Educational Resources Information Center

Kaiser, Nina M.; McBurnett, Keith; Pfiffner, Linda J.

2011-01-01

Objective: Prior research has established links between child social functioning and both parenting and child ADHD severity; however, research examining the way that these variables work together is lacking. The current article aims to test three possible models (main effects, mediation, and moderation) by which ADHD severity and positive and…

[Rating scales based on the phenomenological and structural approach].

PubMed

Schiltz, L

2006-01-01

A current tendency of research in clinical psychology consists in using an integrated quantitative and qualitative methodology. This approach is especially suited to the study of the therapeutic intervention where the researcher is himself part of the situation he is investigating. As to the tools of research, the combination of the semi-structured clinical interview, of psychometric scales and projective tests has proved to be pertinent to describe the multidimensional and fluctuating reality of the therapeutic relationship and the changes induced by it in the two partners. In arts therapeutic research the investigation of the artistic production or of the free expression of people may complete the psychometric and projective tools. The concept of "expressive test" is currently being used to characterise this method. In this context, the development of rating scales, based on the phenomenological and structural or holistic approach allows us making the link between qualitative analysis and quantification, leading to the use of inferential statistics, providing that we remain at the nominal or ordinal level of measurement. We are explaining the principle of construction of these rating scales and we are illustrating our practice with some examples drawn from studies we realized in clinical psychology.

Is It Just a Mole, or Is It More? | Center for Cancer Research

Cancer.gov

Fast and reliable tests that accurately detect and characterize cancer are a major goal in cancer research. At present, histological examination of the cells from a biopsy is the most cost-effective and widely used method for the diagnosis of melanoma. However, this traditional approach does not always reveal the extent of disease progression or adequately guide decisions about treatment strategies. New tests are currently being developed that can detect the proteins made by specific tumor cells and lead to more personalized and better treatment options. The tests that are now available have some drawbacks, which include low sensitivity and inability to detect all types of melanoma cells.

Icing Test Results on an Advanced Two-Dimensional High-Lift Multi-Element Airfoil

NASA Technical Reports Server (NTRS)

Shin, Jaiwon; Wilcox, Peter; Chin, Vincent; Sheldon, David

1994-01-01

An experimental study has been conducted to investigate ice accretions on a high-lift, multi-element airfoil in the Icing Research Tunnel at the NASA Lewis Research Center. The airfoil is representative of an advanced transport wing design. The experimental work was conducted as part of a cooperative program between McDonnell Douglas Aerospace and the NASA Lewis Research Center to improve current understanding of ice accretion characteristics on the multi-element airfoil. The experimental effort also provided ice shapes for future aerodynamic tests at flight Reynolds numbers to ascertain high-lift performance effects. Ice shapes documented for a landing configuration over a variety of icing conditions are presented along with analyses.

Evaluating rodent motor functions: Which tests to choose?

PubMed

Schönfeld, Lisa-Maria; Dooley, Dearbhaile; Jahanshahi, Ali; Temel, Yasin; Hendrix, Sven

2017-12-01

Damage to the motor cortex induced by stroke or traumatic brain injury (TBI) can result in chronic motor deficits. For the development and improvement of therapies, animal models which possess symptoms comparable to the clinical population are used. However, the use of experimental animals raises valid ethical and methodological concerns. To decrease discomfort by experimental procedures and to increase the quality of results, non-invasive and sensitive rodent motor tests are needed. A broad variety of rodent motor tests are available to determine deficits after stroke or TBI. The current review describes and evaluates motor tests that fall into three categories: Tests to evaluate fine motor skills and grip strength, tests for gait and inter-limb coordination and neurological deficit scores. In this review, we share our thoughts on standardized data presentation to increase data comparability between studies. We also critically evaluate current methods and provide recommendations for choosing the best behavioral test for a new research line. Copyright © 2017 Elsevier Ltd. All rights reserved.

Allergens in veterinary medicine.

PubMed

Mueller, R S; Janda, J; Jensen-Jarolim, E; Rhyner, C; Marti, E

2016-01-01

Allergic diseases in animals are increasingly gaining importance in veterinary practice and as research models. For intradermal testing and allergen immunotherapy, a good knowledge of relevant allergens for the individual species is of great importance. Currently, the knowledge about relevant veterinary allergens is based on sensitization rates identified by intradermal testing or serum testing for allergen-specific IgE; crude extracts are the basis for most evaluations. Only a few studies provide evidence about the molecular structure of (particularly) dust mite, insect and mould allergens in dogs and horses, respectively. In those species, some major allergens differ from those in humans. This position paper summarizes the current knowledge about relevant allergens in dogs, cats and horses. © 2015 The Authors Allergy Published by John Wiley & Sons Ltd.

Nanorobotic System iTRo for Controllable 1D Micro/nano Material Twisting Test.

PubMed

Lu, Haojian; Shang, Wanfeng; Wei, Xueyong; Yang, Zhan; Fukuda, Toshio; Shen, Yajing

2017-06-08

In-situ micro/nano characterization is an indispensable methodology for material research. However, the precise in-situ SEM twisting of 1D material with large range is still challenge for current techniques, mainly due to the testing device's large size and the misalignment between specimen and the rotation axis. Herein, we propose an in-situ twist test robot (iTRo) to address the above challenges and realize the precise in-situ SEM twisting test for the first time. Firstly, we developed the iTRo and designed a series of control strategies, including assembly error initialization, triple-image alignment (TIA) method for rotation axis alignment, deformation-based contact detection (DCD) method for sample assembly, and switch control for robots cooperation. After that, we chose three typical 1D material, i.e., magnetic microwire Fe 74 B 13 Si 11 C 2 , glass fiber, and human hair, for twisting test and characterized their properties. The results showed that our approach is able to align the sample to the twisting axis accurately, and it can provide large twisting range, heavy load and high controllability. This work fills the blank of current in-situ mechanical characterization methodologies, which is expected to give significant impact in the fundamental nanomaterial research and practical micro/nano characterization.

University of Washington/ Northwest National Marine Renewable Energy Center Tidal Current Technology Test Protocol, Instrumentation, Design Code, and Oceanographic Modeling Collaboration: Cooperative Research and Development Final Report, CRADA Number CRD-11-452

DOE Office of Scientific and Technical Information (OSTI.GOV)

Driscoll, Frederick R.

The University of Washington (UW) - Northwest National Marine Renewable Energy Center (UW-NNMREC) and the National Renewable Energy Laboratory (NREL) will collaborate to advance research and development (R&D) of Marine Hydrokinetic (MHK) renewable energy technology, specifically renewable energy captured from ocean tidal currents. UW-NNMREC is endeavoring to establish infrastructure, capabilities and tools to support in-water testing of marine energy technology. NREL is leveraging its experience and capabilities in field testing of wind systems to develop protocols and instrumentation to advance field testing of MHK systems. Under this work, UW-NNMREC and NREL will work together to develop a common instrumentation systemmore » and testing methodologies, standards and protocols. UW-NNMREC is also establishing simulation capabilities for MHK turbine and turbine arrays. NREL has extensive experience in wind turbine array modeling and is developing several computer based numerical simulation capabilities for MHK systems. Under this CRADA, UW-NNMREC and NREL will work together to augment single device and array modeling codes. As part of this effort UW NNMREC will also work with NREL to run simulations on NREL's high performance computer system.« less

A Research Agenda for Malaria Eradication: Diagnoses and Diagnostics

PubMed Central

2011-01-01

Many of malaria's signs and symptoms are indistinguishable from those of other febrile diseases. Detection of the presence of Plasmodium parasites is essential, therefore, to guide case management. Improved diagnostic tools are required to enable targeted treatment of infected individuals. In addition, field-ready diagnostic tools for mass screening and surveillance that can detect asymptomatic infections of very low parasite densities are needed to monitor transmission reduction and ensure elimination. Antibody-based tests for infection and novel methods based on biomarkers need further development and validation, as do methods for the detection and treatment of Plasmodium vivax. Current rapid diagnostic tests targeting P. vivax are generally less effective than those targeting Plasmodium falciparum. Moreover, because current drugs for radical cure may cause serious side effects in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, more information is needed on the distribution of G6PD-deficiency variants as well as tests to identify at-risk individuals. Finally, in an environment of very low or absent malaria transmission, sustaining interest in elimination and maintaining resources will become increasingly important. Thus, research is required into the context in which malaria diagnostic tests are used, into diagnostics for other febrile diseases, and into the integration of these tests into health systems. PMID:21311583

Damage Simulation in Composite Materials: Why It Matters and What Is Happening Currently at NASA in This Area

NASA Technical Reports Server (NTRS)

McElroy, Mack; de Carvalho, Nelson; Estes, Ashley; Lin, Shih-yung

2017-01-01

Use of lightweight composite materials in space and aircraft structure designs is often challenging due to high costs associated with structural certification. Of primary concern in the use of composite structures is durability and damage tolerance. This concern is due to the inherent susceptibility of composite materials to both fabrication and service induced flaws. Due to a lack of general industry accepted analysis tools applicable to composites damage simulation, a certification procedure relies almost entirely on testing. It is this reliance on testing, especially compared to structures comprised of legacy metallic materials where damage simulation tools are available, that can drive costs for using composite materials in aerospace structures. The observation that use of composites can be expensive due to testing requirements is not new and as such, research on analysis tools for simulating damage in composite structures has been occurring for several decades. A convenient approach many researchers/model-developers in this area have taken is to select a specific problem relevant to aerospace structural certification and develop a model that is accurate within that scope. Some examples are open hole tension tests, compression after impact tests, low-velocity impact, damage tolerance of an embedded flaw, and fatigue crack growth to name a few. Based on the premise that running analyses is cheaper than running tests, one motivation that many researchers in this area have is that if generally applicable and reliable damage simulation tools were available the dependence on certification testing could be lessened thereby reducing overall design cost. It is generally accepted that simulation tools if applied in this manner would still need to be thoroughly validated and that composite testing will never be completely replaced by analysis. Research and development is currently occurring at NASA to create numerical damage simulation tools applicable to damage in composites. The Advanced Composites Project (ACP) at NASA Langley has supported the development of composites damage simulation tools in a consortium of aerospace companies with a goal of reducing the certification time of a commercial aircraft by 30%. And while the scope of ACP does not include spacecraft, much of the methodology and simulation capabilities can apply to spacecraft certification in the Space Launch System and Orion programs as well. Some specific applications of composite damage simulation models in a certification program are (1) evaluation of damage during service when maintenance may be difficult or impossible, (2) a tool for early design iterations, (3) gaining insight into a particular damage process and applying this insight towards a test coupon or structural design, and (4) analysis of damage scenarios that are difficult or impossible to recreate in a test. As analysis capabilities improve, these applications and more will become realized resulting in a reduction in cost for use of composites in aerospace vehicles. NASA is engaged in this process from both research and application perspectives. In addition to the background information discussed previously, this presentation covers a look at recent research at NASA in this area and some current/potential applications in the Orion program.

Model invariance across genders of the Broad Autism Phenotype Questionnaire.

PubMed

Broderick, Neill; Wade, Jordan L; Meyer, J Patrick; Hull, Michael; Reeve, Ronald E

2015-10-01

ASD is one of the most heritable neuropsychiatric disorders, though comprehensive genetic liability remains elusive. To facilitate genetic research, researchers employ the concept of the broad autism phenotype (BAP), a milder presentation of traits in undiagnosed relatives. Research suggests that the BAP Questionnaire (BAPQ) demonstrates psychometric properties superior to other self-report measures. To examine evidence regarding validity of the BAPQ, the current study used confirmatory factor analysis to test the assumption of model invariance across genders. Results of the current study upheld model invariance at each level of parameter constraint; however, model fit indices suggested limited goodness-of-fit between the proposed model and the sample. Exploratory analyses investigated alternate factor structure models but ultimately supported the proposed three-factor structure model.

On Unsaturated Soil Mechanics - Personal Views on Current Research

NASA Astrophysics Data System (ADS)

Pande, G. N.; Pietruszczak, S.

2015-09-01

This paper presents the authors' personal views on current research being conducted by various research groups around the world in the broad area of mechanics of unsaturated geomaterials in general and soils in particular. The topic is of interest to a wide spectrum of scientists and engineers working in diverse areas such as geology and geophysics, powder technology, agricultural, petroleum, chemical, geotechnical, civil, environmental and nuclear engineering. Even if we restrict ourselves to civil, geotechnical and environmental engineering, it is noted that a plethora of hypotheses as well as a number of empirical and semi-empirical relations have been introduced for describing the mechanics of unsaturated porous media. However, many of these proposed advances as well as methods of testing may lack sound theoretical basis.

Review on the EFDA programme on tungsten materials technology and science

NASA Astrophysics Data System (ADS)

Rieth, M.; Boutard, J. L.; Dudarev, S. L.; Ahlgren, T.; Antusch, S.; Baluc, N.; Barthe, M.-F.; Becquart, C. S.; Ciupinski, L.; Correia, J. B.; Domain, C.; Fikar, J.; Fortuna, E.; Fu, C.-C.; Gaganidze, E.; Galán, T. L.; García-Rosales, C.; Gludovatz, B.; Greuner, H.; Heinola, K.; Holstein, N.; Juslin, N.; Koch, F.; Krauss, W.; Kurzydlowski, K. J.; Linke, J.; Linsmeier, Ch.; Luzginova, N.; Maier, H.; Martínez, M. S.; Missiaen, J. M.; Muhammed, M.; Muñoz, A.; Muzyk, M.; Nordlund, K.; Nguyen-Manh, D.; Norajitra, P.; Opschoor, J.; Pintsuk, G.; Pippan, R.; Ritz, G.; Romaner, L.; Rupp, D.; Schäublin, R.; Schlosser, J.; Uytdenhouwen, I.; van der Laan, J. G.; Veleva, L.; Ventelon, L.; Wahlberg, S.; Willaime, F.; Wurster, S.; Yar, M. A.

2011-10-01

All the recent DEMO design studies for helium cooled divertors utilize tungsten materials and alloys, mainly due to their high temperature strength, good thermal conductivity, low erosion, and comparably low activation under neutron irradiation. The long-term objective of the EFDA fusion materials programme is to develop structural as well as armor materials in combination with the necessary production and fabrication technologies for future divertor concepts. The programmatic roadmap is structured into four engineering research lines which comprise fabrication process development, structural material development, armor material optimization, and irradiation performance testing, which are complemented by a fundamental research programme on "Materials Science and Modeling". This paper presents the current research status of the EFDA experimental and testing investigations, and gives a detailed overview of the latest results on fabrication, joining, high heat flux testing, plasticity, modeling, and validation experiments.

Fighter agility metrics, research, and test

NASA Technical Reports Server (NTRS)

Liefer, Randall K.; Valasek, John; Eggold, David P.

1990-01-01

Proposed new metrics to assess fighter aircraft agility are collected and analyzed. A framework for classification of these new agility metrics is developed and applied. A completed set of transient agility metrics is evaluated with a high fidelity, nonlinear F-18 simulation provided by the NASA Dryden Flight Research Center. Test techniques and data reduction methods are proposed. A method of providing cuing information to the pilot during flight test is discussed. The sensitivity of longitudinal and lateral agility metrics to deviations from the pilot cues is studied in detail. The metrics are shown to be largely insensitive to reasonable deviations from the nominal test pilot commands. Instrumentation required to quantify agility via flight test is also considered. With one exception, each of the proposed new metrics may be measured with instrumentation currently available. Simulation documentation and user instructions are provided in an appendix.

Ground based simulation of life sciences Spacelab experiments

NASA Technical Reports Server (NTRS)

Rummel, J. A.; Alexander, W. C.; Bush, W. H.; Johnston, R. S.

1978-01-01

The third in a series of Spacelab Mission Development tests was a joint effort of the Ames Research and Johnson Space Centers to evaluate planned operational concepts of the Space Shuttle life sciences program. A three-man crew conducted 26 experiments and 12 operational tests, utilizing both human and animal subjects. The crew lived aboard an Orbiter/Spacelab mockup for the seven-day simulation. The Spacelab was identical in geometry to the European Space Agency design, complete with removable rack sections and stowage provisions. Communications were controlled as currently planned for operational Shuttle flights. A Science Operations Remote Center at the Ames Research Center was managed by simulated Mission Control and Payload Operation Control Centers at the Johnson Space Center. This paper presents the test objectives, describes the facilities and test program, and outlines the results of this test.

NASA Agricultural Aircraft Research Program in the Langley Vortex Research Facility and the Langley Full Scale Wind Tunnel

NASA Technical Reports Server (NTRS)

Jordan, F. L., Jr.; Mclemore, H. C.; Bragg, M. B.

1978-01-01

The current status of aerial applications technology research at the Langley's Vortex Research Facility and Full-Scale Wind Tunnel is reviewed. Efforts have been directed mainly toward developing and validating the required experimental and theoretical research tools. A capability to simulate aerial dispersal of materials from agricultural airplanes with small-scale airplane models, numerical methods, and dynamically scaled test particles was demonstrated. Tests on wake modification concepts have proved the feasibility of tailoring wake properties aerodynamically to produce favorable changes in deposition and to provide drift control. An aerodynamic evaluation of the Thrush Commander 800 agricultural airplane with various dispersal systems installed is described. A number of modifications intended to provide system improvement to both airplane and dispersal system are examined, and a technique for documenting near-field spray characteristics is evaluated.

FEAR OF PAST ABUSIVE PARTNER(S) IMPACTS CURRENT POSTTRAUMATIC STRESS AMONG WOMEN EXPERIENCING PARTNER VIOLENCE

PubMed Central

Jaquier, Véronique; Sullivan, Tami P.

2014-01-01

This study examines the impact of fear of past abusive partner(s) on posttraumatic stress among 212 community-recruited women currently exposed to intimate partner violence (IPV). The path analysis model tested explained 60% of the variation in IPV-related posttraumatic stress. Findings revealed that fear of past abusive partner(s) was uniquely associated with the severity of current posttraumatic stress symptoms over and above the impact of current IPV or childhood abuse and neglect. Future research should continue examining women's subjective emotional experience of past and current victimization so as to further inform both clinical practice and intervention planning. PMID:24590514

Test order in teacher-rated behavior assessments: Is counterbalancing necessary?

PubMed

Kooken, Janice; Welsh, Megan E; McCoach, D Betsy; Miller, Faith G; Chafouleas, Sandra M; Riley-Tillman, T Chris; Fabiano, Gregory

2017-01-01

Counterbalancing treatment order in experimental research design is well established as an option to reduce threats to internal validity, but in educational and psychological research, the effect of varying the order of multiple tests to a single rater has not been examined and is rarely adhered to in practice. The current study examines the effect of test order on measures of student behavior by teachers as raters utilizing data from a behavior measure validation study. Using multilevel modeling to control for students nested within teachers, the effect of rating an earlier measure on the intercept or slope of a later behavior assessment was statistically significant in 22% of predictor main effects for the spring test period. Test order effects had potential for high stakes consequences with differences large enough to change risk classification. Results suggest that researchers and practitioners in classroom settings using multiple measures evaluate the potential impact of test order. Where possible, they should counterbalance when the risk of an order effect exists and report justification for the decision to not counterbalance. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

A Web-based Alternative Non-animal Method Database for Safety Cosmetic Evaluations

PubMed Central

Kim, Seung Won; Kim, Bae-Hwan

2016-01-01

Animal testing was used traditionally in the cosmetics industry to confirm product safety, but has begun to be banned; alternative methods to replace animal experiments are either in development, or are being validated, worldwide. Research data related to test substances are critical for developing novel alternative tests. Moreover, safety information on cosmetic materials has neither been collected in a database nor shared among researchers. Therefore, it is imperative to build and share a database of safety information on toxicological mechanisms and pathways collected through in vivo, in vitro, and in silico methods. We developed the CAMSEC database (named after the research team; the Consortium of Alternative Methods for Safety Evaluation of Cosmetics) to fulfill this purpose. On the same website, our aim is to provide updates on current alternative research methods in Korea. The database will not be used directly to conduct safety evaluations, but researchers or regulatory individuals can use it to facilitate their work in formulating safety evaluations for cosmetic materials. We hope this database will help establish new alternative research methods to conduct efficient safety evaluations of cosmetic materials. PMID:27437094

A Web-based Alternative Non-animal Method Database for Safety Cosmetic Evaluations.

PubMed

Kim, Seung Won; Kim, Bae-Hwan

2016-07-01

Animal testing was used traditionally in the cosmetics industry to confirm product safety, but has begun to be banned; alternative methods to replace animal experiments are either in development, or are being validated, worldwide. Research data related to test substances are critical for developing novel alternative tests. Moreover, safety information on cosmetic materials has neither been collected in a database nor shared among researchers. Therefore, it is imperative to build and share a database of safety information on toxicological mechanisms and pathways collected through in vivo, in vitro, and in silico methods. We developed the CAMSEC database (named after the research team; the Consortium of Alternative Methods for Safety Evaluation of Cosmetics) to fulfill this purpose. On the same website, our aim is to provide updates on current alternative research methods in Korea. The database will not be used directly to conduct safety evaluations, but researchers or regulatory individuals can use it to facilitate their work in formulating safety evaluations for cosmetic materials. We hope this database will help establish new alternative research methods to conduct efficient safety evaluations of cosmetic materials.

Use of clinical movement screening tests to predict injury in sport

PubMed Central

Chimera, Nicole J; Warren, Meghan

2016-01-01

Clinical movement screening tests are gaining popularity as a means to determine injury risk and to implement training programs to prevent sport injury. While these screens are being used readily in the clinical field, it is only recently that some of these have started to gain attention from a research perspective. This limits applicability and poses questions to the validity, and in some cases the reliability, of the clinical movement tests as they relate to injury prediction, intervention, and prevention. This editorial will review the following clinical movement screening tests: Functional Movement Screen™, Star Excursion Balance Test, Y Balance Test, Drop Jump Screening Test, Landing Error Scoring System, and the Tuck Jump Analysis in regards to test administration, reliability, validity, factors that affect test performance, intervention programs, and usefulness for injury prediction. It is important to review the aforementioned factors for each of these clinical screening tests as this may help clinicians interpret the current body of literature. While each of these screening tests were developed by clinicians based on what appears to be clinical practice, this paper brings to light that this is a need for collaboration between clinicians and researchers to ensure validity of clinically meaningful tests so that they are used appropriately in future clinical practice. Further, this editorial may help to identify where the research is lacking and, thus, drive future research questions in regards to applicability and appropriateness of clinical movement screening tools. PMID:27114928

Clinimetric properties of lower limb neurological impairment tests for children and young people with a neurological condition: A systematic review

PubMed Central

Locke, Melissa; Hill, Bridget; Wells, Cherie; Bialocerkowski, Andrea

2017-01-01

Background Clinicians and researchers require sound neurological tests to measure changes in neurological impairments necessary for clinical decision-making. Little evidence-based guidance exists for selecting and interpreting an appropriate, paediatric-specific lower limb neurological test aimed at the impairment level. Objective To determine the clinimetric evidence underpinning neurological impairment tests currently used in paediatric rehabilitation to evaluate muscle strength, tactile sensitivity, and deep tendon reflexes of the lower limb in children and young people with a neurological condition. Methods Thirteen databases were systematically searched in two phases, from the date of database inception to 16 February 2017. Lower limb neurological impairment tests were first identified which evaluated muscle strength, tactile sensitivity or deep tendon reflexes in children or young people under 18 years of age with a neurological condition. Papers containing clinimetric evidence of these tests were then identified. The methodological quality of each paper was critically appraised using standardised tools and clinimetric evidence synthesised for each test. Results Thirteen papers were identified, which provided clinimetric evidence on six neurological tests. Muscle strength tests had the greatest volume of clinimetric evidence, however this evidence focused on reliability. Studies were variable in quality with inconsistent results. Clinimetric evidence for tactile sensitivity impairment tests was conflicting and difficult to extrapolate. No clinimetric evidence was found for impairment tests of deep tendon reflexes. Conclusions Limited high-quality clinimetric evidence exists for lower limb neurological impairment tests in children and young people with a neurological condition. Results of currently used neurological tests, therefore, should be interpreted with caution. Robust clinimetric evidence on these tests is required for clinicians and researchers to effectively select and evaluate rehabilitation interventions. PMID:28671957

Characterization of Viscoelastic Materials for Low-Magnitude Blast Mitigation

NASA Astrophysics Data System (ADS)

Bartyczak, Susan; Mock, Willis

2013-06-01

Recent preliminary research indicates that exposure to low amplitude blast waves, such as from IED detonation or multiple firings of a weapon, causes damage to brain tissue resulting in Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD). Current combat helmets are not sufficiently protecting warfighters from this danger and the effects are debilitating, costly, and long-lasting. The objective of this research is to evaluate the blast mitigating behavior of current helmet materials and new materials designed for blast mitigation using a test fixture recently developed at the Naval Surface Warfare Center Dahlgren Division for use with an existing gas gun. A 40-mm-bore gas gun is used as a shock tube to generate blast waves (ranging from 5 to 30 psi) in a test fixture mounted at the gun muzzle. A fast opening valve is used to release helium gas from a breech which forms into a blast wave and impacts instrumented targets in the test fixture. Blast attenuation of selected materials is determined through the measurement of pressure and accelerometer data in front of and behind the target. Materials evaluated in this research include 6061-T6 aluminum, polyurea 1000, Styrofoam, and Sorbothane (durometer 50, shore 00). The experimental technique, calibration and checkout procedures, and results will be presented.

Legal implications of genetics and crime research.

PubMed

Denno, D W

1996-01-01

Two controversial topics dominate discussions of the legal implications of genetics and crime research; (1) the viability and politics of such research, which has sparked fervent debate in the USA; and (2) the current status of new or atypical criminal law defences, which would include a genetic-defect defence to criminal behaviour. This chapter begins by examining the scientifically discredited XYY chromosome syndrome defence, the major genetic-defect defence that defendants have attempted, albeit unsuccessfully. It then focuses on attorneys' efforts to test for evidence of genetic abnormality in the recent and highly publicized case involving convicted murderer Stephen Mobley, whose family history reveals four generations of violent, aggressive and behaviourally disordered men and women. Mobley is currently appealing his death sentence before the Georgia Supreme Court on the basis that the trial court denied his request both to have genetic testing performed and to have such testing allowed as evidence into court. This chapter concludes by emphasizing that the question is not whether genetic evidence will ever be admitted into court, but when and under what kinds of circumstances. No doubt, genetic evidence, and comparable kinds of biological evidence, will have a major impact on juries when such evidence is more fully accepted by the legal and scientific communities.

Rheoencephalographic and electroencephalographic measures of cognitive workload: analytical procedures.

PubMed

Montgomery, L D; Montgomery, R W; Guisado, R

1995-05-01

This investigation demonstrates the feasibility of mental workload assessment by rheoencephalographic (REG) and multichannel electroencephalographic (EEG) monitoring. During the performance of this research, unique testing, analytical and display procedures were developed for REG and EEG monitoring that extend the current state of the art and provide valuable tools for the study of cerebral circulatory and neural activity during cognition. REG records are analyzed to provide indices of the right and left hemisphere hemodynamic changes that take place during each test sequence. The EEG data are modeled using regression techniques and mathematically transformed to provide energy-density distributions of the scalp electrostatic field. These procedures permit concurrent REG/EEG cognitive testing not possible with current techniques. The introduction of a system for recording and analysis of cognitive REG/EEG test sequences facilitates the study of learning and memory disorders, dementia and other encephalopathies.

Rheoencephalographic and electroencephalographic measures of cognitive workload: analytical procedures

NASA Technical Reports Server (NTRS)

Montgomery, L. D.; Montgomery, R. W.; Guisado, R.

1995-01-01

This investigation demonstrates the feasibility of mental workload assessment by rheoencephalographic (REG) and multichannel electroencephalographic (EEG) monitoring. During the performance of this research, unique testing, analytical and display procedures were developed for REG and EEG monitoring that extend the current state of the art and provide valuable tools for the study of cerebral circulatory and neural activity during cognition. REG records are analyzed to provide indices of the right and left hemisphere hemodynamic changes that take place during each test sequence. The EEG data are modeled using regression techniques and mathematically transformed to provide energy-density distributions of the scalp electrostatic field. These procedures permit concurrent REG/EEG cognitive testing not possible with current techniques. The introduction of a system for recording and analysis of cognitive REG/EEG test sequences facilitates the study of learning and memory disorders, dementia and other encephalopathies.

What is the need for comparative effectiveness studies in IBD?

PubMed

Flasar, Mark H; Cross, Raymond K

2014-11-01

Unlike traditional clinical trial research, Comparative Effectiveness Research seeks to determine what is 'best' for a typical patient when deciding between effective options used in daily practice - a therapy, diagnostic test, or course of action. There is a clear need for Comparative Effectiveness Research in Inflammatory Bowel Disease, a point emphasized by the Institute of Medicine and supported by governmental agencies and escalating funding. This review highlights the rationale and support for Comparative Effectiveness Research, provides examples of Comparative Effectiveness Research in Inflammatory Bowel Disease, and outlines current and future focus for Comparative Effectiveness Research in Inflammatory Bowel Disease.

[Integration of sex/gender into environmental health research. Results of the interdisciplinary research network Sex/Gender-Environment-Health (GeUmGe-NET)].

PubMed

Bolte, Gabriele; David, Madlen; Dębiak, Małgorzata; Fiedel, Lotta; Hornberg, Claudia; Kolossa-Gehring, Marike; Kraus, Ute; Lätzsch, Rebecca; Paeck, Tatjana; Palm, Kerstin; Schneider, Alexandra

2018-06-01

The comprehensive consideration of sex/gender in health research is essential to increase relevance and validity of research results. Contrary to other areas of health research, there is no systematic summary of the current state of research on the significance of sex/gender in environmental health. Within the interdisciplinary research network Sex/Gender-Environment-Health (GeUmGe-NET) the current state of integration of sex/gender aspects or, respectively, gender theoretical concepts into research was systematically assessed within selected topics of the research areas environmental toxicology, environmental medicine, environmental epidemiology and public health research on environment and health. Knowledge gaps and research needs were identified in all research areas. Furthermore, the potential for methodological advancements by using gender theoretical concepts was depicted. A dialogue between biomedical research, public health research, and gender studies was started with the research network GeUmGe-NET. This dialogue has to be continued particularly regarding a common testing of methodological innovations in data collection and data analysis. Insights of this interdisciplinary research are relevant for practice areas such as environmental health protection, health promotion, environmental justice, and environmental health monitoring.

Modified Vaccinia Virus Ankara: History, Value in Basic Research, and Current Perspectives for Vaccine Development.

PubMed

Volz, A; Sutter, G

2017-01-01

Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment. As a biologically well-characterized mutant virus, MVA facilitates fundamental research to elucidate the functions of poxvirus host-interaction factors. As extremely safe viral vectors MVA vaccines have been found immunogenic and protective in various preclinical infection models. Multiple recombinant MVA currently undergo clinical testing for vaccination against human immunodeficiency viruses, Mycobacterium tuberculosis or Plasmodium falciparum. The versatility of the MVA vector vaccine platform is readily demonstrated by the swift development of experimental vaccines for immunization against emerging infections such as the Middle East Respiratory Syndrome. Recent advances include promising results from the clinical testing of recombinant MVA-producing antigens of highly pathogenic avian influenza virus H5N1 or Ebola virus. This review summarizes our current knowledge about MVA as a unique strain of vaccinia virus, and discusses the prospects of exploiting this virus as research tool in poxvirus biology or as safe viral vector vaccine to challenge existing and future bottlenecks in vaccinology. © 2017 Elsevier Inc. All rights reserved.

Fast solver for large scale eddy current non-destructive evaluation problems

NASA Astrophysics Data System (ADS)

Lei, Naiguang

Eddy current testing plays a very important role in non-destructive evaluations of conducting test samples. Based on Faraday's law, an alternating magnetic field source generates induced currents, called eddy currents, in an electrically conducting test specimen. The eddy currents generate induced magnetic fields that oppose the direction of the inducing magnetic field in accordance with Lenz's law. In the presence of discontinuities in material property or defects in the test specimen, the induced eddy current paths are perturbed and the associated magnetic fields can be detected by coils or magnetic field sensors, such as Hall elements or magneto-resistance sensors. Due to the complexity of the test specimen and the inspection environments, the availability of theoretical simulation models is extremely valuable for studying the basic field/flaw interactions in order to obtain a fuller understanding of non-destructive testing phenomena. Theoretical models of the forward problem are also useful for training and validation of automated defect detection systems. Theoretical models generate defect signatures that are expensive to replicate experimentally. In general, modelling methods can be classified into two categories: analytical and numerical. Although analytical approaches offer closed form solution, it is generally not possible to obtain largely due to the complex sample and defect geometries, especially in three-dimensional space. Numerical modelling has become popular with advances in computer technology and computational methods. However, due to the huge time consumption in the case of large scale problems, accelerations/fast solvers are needed to enhance numerical models. This dissertation describes a numerical simulation model for eddy current problems using finite element analysis. Validation of the accuracy of this model is demonstrated via comparison with experimental measurements of steam generator tube wall defects. These simulations generating two-dimension raster scan data typically takes one to two days on a dedicated eight-core PC. A novel direct integral solver for eddy current problems and GPU-based implementation is also investigated in this research to reduce the computational time.

Flight Test Results of an Angle of Attack and Angle of Sideslip Calibration Method Using Output-Error Optimization

NASA Technical Reports Server (NTRS)

Siu, Marie-Michele; Martos, Borja; Foster, John V.

2013-01-01

As part of a joint partnership between the NASA Aviation Safety Program (AvSP) and the University of Tennessee Space Institute (UTSI), research on advanced air data calibration methods has been in progress. This research was initiated to expand a novel pitot-static calibration method that was developed to allow rapid in-flight calibration for the NASA Airborne Subscale Transport Aircraft Research (AirSTAR) facility. This approach uses Global Positioning System (GPS) technology coupled with modern system identification methods that rapidly computes optimal pressure error models over a range of airspeed with defined confidence bounds. Subscale flight tests demonstrated small 2-s error bounds with significant reduction in test time compared to other methods. Recent UTSI full scale flight tests have shown airspeed calibrations with the same accuracy or better as the Federal Aviation Administration (FAA) accepted GPS 'four-leg' method in a smaller test area and in less time. The current research was motivated by the desire to extend this method for inflight calibration of angle of attack (AOA) and angle of sideslip (AOS) flow vanes. An instrumented Piper Saratoga research aircraft from the UTSI was used to collect the flight test data and evaluate flight test maneuvers. Results showed that the output-error approach produces good results for flow vane calibration. In addition, maneuvers for pitot-static and flow vane calibration can be integrated to enable simultaneous and efficient testing of each system.

Options for flight testing rocket-based combined-cycle (RBCC) engines

NASA Technical Reports Server (NTRS)

Olds, John

1996-01-01

While NASA's current next-generation launch vehicle research has largely focused on advanced all-rocket single-stage-to-orbit vehicles (i.e. the X-33 and it's RLV operational follow-on), some attention is being given to advanced propulsion concepts suitable for 'next-generation-and-a-half' vehicles. Rocket-based combined-cycle (RBCC) engines combining rocket and airbreathing elements are one candidate concept. Preliminary RBCC engine development was undertaken by the United States in the 1960's. However, additional ground and flight research is required to bring the engine to technological maturity. This paper presents two options for flight testing early versions of the RBCC ejector scramjet engine. The first option mounts a single RBCC engine module to the X-34 air-launched technology testbed for test flights up to about Mach 6.4. The second option links RBCC engine testing to the simultaneous development of a small-payload (220 lb.) two-stage-to-orbit operational vehicle in the Bantam payload class. This launcher/testbed concept has been dubbed the W vehicle. The W vehicle can also serve as an early ejector ramjet RBCC launcher (albeit at a lower payload). To complement current RBCC ground testing efforts, both flight test engines will use earth-storable propellants for their RBCC rocket primaries and hydrocarbon fuel for their airbreathing modes. Performance and vehicle sizing results are presented for both options.

Development and application of optimum sensitivity analysis of structures

NASA Technical Reports Server (NTRS)

Barthelemy, J. F. M.; Hallauer, W. L., Jr.

1984-01-01

The research focused on developing an algorithm applying optimum sensitivity analysis for multilevel optimization. The research efforts have been devoted to assisting NASA Langley's Interdisciplinary Research Office (IRO) in the development of a mature methodology for a multilevel approach to the design of complex (large and multidisciplinary) engineering systems. An effort was undertaken to identify promising multilevel optimization algorithms. In the current reporting period, the computer program generating baseline single level solutions was completed and tested out.

Fundamental research in the area of high temperature fuel cells in Russia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dyomin, A.K.

1996-04-01

Research in the area of molten carbonate and solid oxide fuel cells has been conducted in Russia since the late 60`s. Institute of High Temperature Electrochemistry is the lead organisation in this area. Research in the area of materials used in fuel cells has allowed us to identify compositions of electrolytes, electrodes, current paths and transmitting, sealing and structural materials appropriate for long-term fuel cell applications. Studies of electrode processes resulted in better understanding of basic patterns of electrode reactions and in the development of a foundation for electrode structure optimization. We have developed methods to increase electrode activity levelsmore » that allowed us to reach current density levels of up to 1 amper/cm{sup 2}. Development of mathematical models of processes in high temperature fuel cells has allowed us to optimize their structure. The results of fundamental studies have been tested on laboratory mockups. MCFC mockups with up to 100 W capacity and SOFC mockups with up to 1 kW capacity have been manufactured and tested at IHTE. There are three SOFC structural options: tube, plate and modular.« less

Uncertainties in Estimates of Fleet Average Fuel Economy : A Statistical Evaluation

DOT National Transportation Integrated Search

1977-01-01

Research was performed to assess the current Federal procedure for estimating the average fuel economy of each automobile manufacturer's new car fleet. Test vehicle selection and fuel economy estimation methods were characterized statistically and so...

Laboratory evaluation of asphalt binder rutting, fracture, and adhesion tests.

DOT National Transportation Integrated Search

2014-04-01

The current performance grading (PG) specification for asphalt binders was developed based on the Strategic Highway : Research Program (SHRP) and is based primarily on the study of unmodified asphalt binders. Over the years, experience has : proven t...

Perspectives on Genetic and Genomic Technologies in an Academic Medical Center: The Duke Experience

PubMed Central

Katsanis, Sara Huston; Minear, Mollie A.; Vorderstrasse, Allison; Yang, Nancy; Reeves, Jason W.; Rakhra-Burris, Tejinder; Cook-Deegan, Robert; Ginsburg, Geoffrey S.; Simmons, Leigh Ann

2015-01-01

In this age of personalized medicine, genetic and genomic testing is expected to become instrumental in health care delivery, but little is known about its actual implementation in clinical practice. Methods. We surveyed Duke faculty and healthcare providers to examine the extent of genetic and genomic testing adoption. We assessed providers’ use of genetic and genomic testing options and indications in clinical practice, providers’ awareness of pharmacogenetic applications, and providers’ opinions on returning research-generated genetic test results to participants. Most clinician respondents currently use family history routinely in their clinical practice, but only 18 percent of clinicians use pharmacogenetics. Only two respondents correctly identified the number of drug package inserts with pharmacogenetic indications. We also found strong support for the return of genetic research results to participants. Our results demonstrate that while Duke healthcare providers are enthusiastic about genomic technologies, use of genomic tools outside of research has been limited. Respondents favor return of research-based genetic results to participants, but clinicians lack knowledge about pharmacogenetic applications. We identified challenges faced by this institution when implementing genetic and genomic testing into patient care that should inform a policy and education agenda to improve provider support and clinician-researcher partnerships. PMID:25854543

Implementation of the Enhanced Flight Termination System at National Aeronautics and Space Administration Dryden Flight Research Center

NASA Technical Reports Server (NTRS)

Tow, David

2010-01-01

This paper discusses the methodology, requirements, tests, and results of the implementation of the current operating capability for the Enhanced Flight Termination System (EFTS) at the National Aeronautics and Space Administration (NASA) Dryden Flight Research Center (DFRC). The implementation involves the development of the EFTS at NASA DFRC starting from the requirements to system safety review to full end to end system testing, and concluding with the acceptance of the system as an operational system. The paper discusses the first operational usage and subsequent flight utilizing EFTS successfully.

Applying the design-build-test paradigm in microbiome engineering.

PubMed

Pham, Hoang Long; Ho, Chun Loong; Wong, Adison; Lee, Yung Seng; Chang, Matthew Wook

2017-12-01

The recently discovered roles of human microbiome in health and diseases have inspired research efforts across many disciplines to engineer microbiome for health benefits. In this review, we highlight recent progress in human microbiome research and how modifications to the microbiome could result in implications to human health. Furthermore, we discuss the application of a 'design-build-test' framework to expedite microbiome engineering efforts by reviewing current literature on three key aspects: design principles to engineer the human microbiome, methods to engineer microbiome with desired functions, and analytical techniques to examine complex microbiome samples. Copyright © 2017 Elsevier Ltd. All rights reserved.

Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down’s syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units

PubMed Central

Wright, David; Hill, Melissa; Verhoef, Talitha I; Daley, Rebecca; Lewis, Celine; Mason, Sarah; McKay, Fiona; Jenkins, Lucy; Howarth, Abigail; Cameron, Louise; McEwan, Alec; Fisher, Jane; Kroese, Mark; Morris, Stephen

2016-01-01

Objective To investigate the benefits and costs of implementing non-invasive prenatal testing (NIPT) for Down’s syndrome into the NHS maternity care pathway. Design Prospective cohort study. Setting Eight maternity units across the United Kingdom between 1 November 2013 and 28 February 2015. Participants All pregnant women with a current Down’s syndrome risk on screening of at least 1/1000. Main outcome measures Outcomes were uptake of NIPT, number of cases of Down’s syndrome detected, invasive tests performed, and miscarriages avoided. Pregnancy outcomes and costs associated with implementation of NIPT, compared with current screening, were determined using study data on NIPT uptake and invasive testing in combination with national datasets. Results NIPT was prospectively offered to 3175 pregnant women. In 934 women with a Down’s syndrome risk greater than 1/150, 695 (74.4%) chose NIPT, 166 (17.8%) chose invasive testing, and 73 (7.8%) declined further testing. Of 2241 women with risks between 1/151 and 1/1000, 1799 (80.3%) chose NIPT. Of 71 pregnancies with a confirmed diagnosis of Down’s syndrome, 13/42 (31%) with the diagnosis after NIPT and 2/29 (7%) after direct invasive testing continued, resulting in 12 live births. In an annual screening population of 698 500, offering NIPT as a contingent test to women with a Down’s syndrome screening risk of at least 1/150 would increase detection by 195 (95% uncertainty interval −34 to 480) cases with 3368 (2279 to 4027) fewer invasive tests and 17 (7 to 30) fewer procedure related miscarriages, for a non-significant difference in total costs (£−46 000, £−1 802 000 to £2 661 000). The marginal cost of NIPT testing strategies versus current screening is very sensitive to NIPT costs; at a screening threshold of 1/150, NIPT would be cheaper than current screening if it cost less than £256. Lowering the risk threshold increases the number of Down’s syndrome cases detected and overall costs, while maintaining the reduction in invasive tests and procedure related miscarriages. Conclusions Implementation of NIPT as a contingent test within a public sector Down’s syndrome screening programme can improve quality of care, choices for women, and overall performance within the current budget. As some women use NIPT for information only, the Down’s syndrome live birth rate may not change significantly. Future research should consider NIPT uptake and informed decision making outside of a research setting. PMID:27378786

Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down's syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units.

PubMed

Chitty, Lyn S; Wright, David; Hill, Melissa; Verhoef, Talitha I; Daley, Rebecca; Lewis, Celine; Mason, Sarah; McKay, Fiona; Jenkins, Lucy; Howarth, Abigail; Cameron, Louise; McEwan, Alec; Fisher, Jane; Kroese, Mark; Morris, Stephen

2016-07-04

 To investigate the benefits and costs of implementing non-invasive prenatal testing (NIPT) for Down's syndrome into the NHS maternity care pathway.  Prospective cohort study.  Eight maternity units across the United Kingdom between 1 November 2013 and 28 February 2015.  All pregnant women with a current Down's syndrome risk on screening of at least 1/1000.  Outcomes were uptake of NIPT, number of cases of Down's syndrome detected, invasive tests performed, and miscarriages avoided. Pregnancy outcomes and costs associated with implementation of NIPT, compared with current screening, were determined using study data on NIPT uptake and invasive testing in combination with national datasets.  NIPT was prospectively offered to 3175 pregnant women. In 934 women with a Down's syndrome risk greater than 1/150, 695 (74.4%) chose NIPT, 166 (17.8%) chose invasive testing, and 73 (7.8%) declined further testing. Of 2241 women with risks between 1/151 and 1/1000, 1799 (80.3%) chose NIPT. Of 71 pregnancies with a confirmed diagnosis of Down's syndrome, 13/42 (31%) with the diagnosis after NIPT and 2/29 (7%) after direct invasive testing continued, resulting in 12 live births. In an annual screening population of 698 500, offering NIPT as a contingent test to women with a Down's syndrome screening risk of at least 1/150 would increase detection by 195 (95% uncertainty interval -34 to 480) cases with 3368 (2279 to 4027) fewer invasive tests and 17 (7 to 30) fewer procedure related miscarriages, for a non-significant difference in total costs (£-46 000, £-1 802 000 to £2 661 000). The marginal cost of NIPT testing strategies versus current screening is very sensitive to NIPT costs; at a screening threshold of 1/150, NIPT would be cheaper than current screening if it cost less than £256. Lowering the risk threshold increases the number of Down's syndrome cases detected and overall costs, while maintaining the reduction in invasive tests and procedure related miscarriages.  Implementation of NIPT as a contingent test within a public sector Down's syndrome screening programme can improve quality of care, choices for women, and overall performance within the current budget. As some women use NIPT for information only, the Down's syndrome live birth rate may not change significantly. Future research should consider NIPT uptake and informed decision making outside of a research setting. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

The Test and Evaluation of a Non-Chromate Finishing Agent

NASA Technical Reports Server (NTRS)

Gulley, H.; Okhio, C. B.; Tacina, Robert (Technical Monitor)

2000-01-01

This research is focused on the design, development and implementation of an industry, military and commercial standard testing cell for surface coatings, which focuses on advanced non-chromate materials technology and their commercialization. Currently, within both private and commercial sectors, chromates are used in the corrosion prevention. processes. However, there is a great demand for chromate-free systems that are able to provide equal protection. At the end of this effort, it is intended that a patented alternative to chromate conversion coatings would be tested and processed for commercialization. Thus far, research studies have been concerned primarily with current corrosion knowledge and testing methods. Corrosion can be classified into five categories: The first type is uniform corrosion which is dominated by a uniform thinning due to an even and regular loss of metal. The second type is called localized corrosion in which most of the loss occurs in discrete areas. The third type, metallurgically influenced corrosion is a form of attack where metallurgy plays a significant role. The fourth type, titled mechanically assisted degradation is a form of attack where velocity, abrasion, and hydrodynamics control the corrosion process. The last type of corrosion is defined as environmentally induced cracking which occurs when cracks are produced under specific, premeditated stress. Oddly enough, with these varying classifications, there are not as many standardized corrosion testing sites. Two of the most common testing methods for corrosion are salt spray testing and filiform. Although neither has proven to be absolute, in terms of the resulting observations, our research aims to help provide data that may be used to support the standardization for corrosion testing. We would acquire and use a Singleton Cyclic Corrosion Testing Chamber. Singleton test chambers perform a wide range of commonly used catalytic corrosion tests. They are used throughout the industry, some of which are - automotive, aerospace, electronic and many more. In addition to this, Singleton test chambers are fully expandable to accommodate cyclic corrosion testing needs. Singleton chambers are also designed for complete compliance and conformity with ASTM (American Society for Testing and Materials), military and commercial standards.

Effects of Droplet Size on Intrusion of Sub-Surface Oil Spills

NASA Astrophysics Data System (ADS)

Adams, Eric; Chan, Godine; Wang, Dayang

2014-11-01

We explore effects of droplet size on droplet intrusion and transport in sub-surface oil spills. Negatively buoyant glass beads released continuously to a stratified ambient simulate oil droplets in a rising multiphase plume, and distributions of settled beads are used to infer signatures of surfacing oil. Initial tests used quiescent conditions, while ongoing tests simulate currents by towing the source and a bottom sled. Without current, deposited beads have a Gaussian distribution, with variance increasing with decreasing particle size. Distributions agree with a model assuming first order particle loss from an intrusion layer of constant thickness, and empirically determined flow rate. With current, deposited beads display a parabolic distribution similar to that expected from a source in uniform flow; we are currently comparing observed distributions with similar analytical models. Because chemical dispersants have been used to reduce oil droplet size, our study provides one measure of their effectiveness. Results are applied to conditions from the `Deep Spill' field experiment, and the recent Deepwater Horizon oil spill, and are being used to provide ``inner boundary conditions'' for subsequent far field modeling of these events. This research was made possible by grants from Chevron Energy Technology Co., through the Chevron-MITEI University Partnership Program, and BP/The Gulf of Mexico Research Initiative, GISR.

Aeroservoelastic and Structural Dynamics Research on Smart Structures Conducted at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

McGowan, Anna-Maria Rivas; Wilkie, W. Keats; Moses, Robert W.; Lake, Renee C.; Florance, Jennifer Pinkerton; Wieseman, Carol D.; Reaves, Mercedes C.; Taleghani, Barmac K.; Mirick, Paul H.; Wilbur, Mathew L.

1997-01-01

An overview of smart structures research currently underway at the NASA Langley Research Center in the areas of aeroservoelasticity and structural dynamics is presented. Analytical and experimental results, plans, potential technology pay-offs, and challenges are discussed. The goal of this research is to develop the enabling technologies to actively and passively control aircraft and rotorcraft vibration and loads using smart devices. These enabling technologies and related research efforts include developing experimentally-validated finite element and aeroservoelastic modeling techniques; conducting bench experimental tests to assess feasibility and understand system trade-offs; and conducting large-scale wind tunnel tests to demonstrate system performance. The key aeroservoelastic applications of this research include: active twist control of rotor blades using interdigitated electrode piezoelectric composites and active control of flutter, and gust and buffeting responses using discrete piezoelectric patches. In addition, NASA Langley is an active participant in the DARPA/Air Force Research Laboratory/NASA/Northrop Grumman Smart Wing program which is assessing aerodynamic performance benefits using smart materials.

Overview of Glenn Mechanical Components Branch Research

NASA Astrophysics Data System (ADS)

Zakrajsek, James

2002-09-01

Mr. James Zakrajsek, chief of the Mechanical Components Branch, gave an overview of research conducted by the branch. Branch members perform basic research on mechanical components and systems, including gears and bearings, turbine seals, structural and thermal barrier seals, and space mechanisms. The research is focused on propulsion systems for present and advanced aerospace vehicles. For rotorcraft and conventional aircraft, we conduct research to develop technology needed to enable the design of low noise, ultra safe geared drive systems. We develop and validate analytical models for gear crack propagation, gear dynamics and noise, gear diagnostics, bearing dynamics, and thermal analyses of gear systems using experimental data from various component test rigs. In seal research we develop and test advanced turbine seal concepts to increase efficiency and durability of turbine engines. We perform experimental and analytical research to develop advanced thermal barrier seals and structural seals for current and next generation space vehicles. Our space mechanisms research involves fundamental investigation of lubricants, materials, components and mechanisms for deep space and planetary environments.

Ambient Pressure Test Rig Developed for Testing Oil-Free Bearings in Alternate Gases and Variable Pressures

NASA Technical Reports Server (NTRS)

Bauman, Steven W.

1990-01-01

The Oil-Free Turbomachinery research team at the NASA Glenn Research Center is conducting research to develop turbomachinery systems that utilize high-speed, high temperature foil (air) bearings that do not require an oil lubrication system. Such systems combine the most advanced foil bearings from industry with NASA-developed hightemperature solid-lubricant technology. New applications are being pursued, such as Oil- Free turbochargers, auxiliary power units, and turbine propulsion systems for aircraft. An Oil-Free business jet engine, for example, would be simpler, lighter, more reliable, and less costly to purchase and maintain than current engines. Another application is NASA's Prometheus mission, where gas bearings will be required for the closed-cycle turbine based power-conversion system of a nuclear power generator for deep space. To support these applications, Glenn's Oil-Free Turbomachinery research team developed the Ambient Pressure Test Rig. Using this facility, researchers can load and heat a bearing and evaluate its performance with reduced air pressure to simulate high altitude conditions. For the nuclear application, the test chamber can be purged with gases such as helium to study foil gas bearing operation in working fluids other than air.

Model-based analysis of costs and outcomes of non-invasive prenatal testing for Down's syndrome using cell free fetal DNA in the UK National Health Service.

PubMed

Morris, Stephen; Karlsen, Saffron; Chung, Nancy; Hill, Melissa; Chitty, Lyn S

2014-01-01

Non-invasive prenatal testing (NIPT) for Down's syndrome (DS) using cell free fetal DNA in maternal blood has the potential to dramatically alter the way prenatal screening and diagnosis is delivered. Before NIPT can be implemented into routine practice, information is required on its costs and benefits. We investigated the costs and outcomes of NIPT for DS as contingent testing and as first-line testing compared with the current DS screening programme in the UK National Health Service. We used a pre-existing model to evaluate the costs and outcomes associated with NIPT compared with the current DS screening programme. The analysis was based on a hypothetical screening population of 10,000 pregnant women. Model inputs were taken from published sources. The main outcome measures were number of DS cases detected, number of procedure-related miscarriages and total cost. At a screening risk cut-off of 1∶150 NIPT as contingent testing detects slightly fewer DS cases, has fewer procedure-related miscarriages, and costs the same as current DS screening (around UK£280,000) at a cost of £500 per NIPT. As first-line testing NIPT detects more DS cases, has fewer procedure-related miscarriages, and is more expensive than current screening at a cost of £50 per NIPT. When NIPT uptake increases, NIPT detects more DS cases with a small increase in procedure-related miscarriages and costs. NIPT is currently available in the private sector in the UK at a price of £400-£900. If the NHS cost was at the lower end of this range then at a screening risk cut-off of 1∶150 NIPT as contingent testing would be cost neutral or cost saving compared with current DS screening. As first-line testing NIPT is likely to produce more favourable outcomes but at greater cost. Further research is needed to evaluate NIPT under real world conditions.

Primary care providers' cancer genetic testing-related knowledge, attitudes, and communication behaviors: A systematic review and research agenda.

PubMed

Hamilton, Jada G; Abdiwahab, Ekland; Edwards, Heather M; Fang, Min-Lin; Jdayani, Andrew; Breslau, Erica S

2017-03-01

Primary care providers (PCPs) can play a critical role in helping patients receive the preventive health benefits of cancer genetic risk information. Thus, the objective of this systematic review was to identify studies of US PCPs' knowledge, attitudes, and communication-related behaviors regarding genetic tests that could inform risk-stratification approaches for breast, colorectal, and prostate cancer screening in order to describe current findings and research gaps. We conducted a systematic search of six electronic databases to identify peer-reviewed empirical articles relating to US PCPs and genetic testing for breast, colorectal, or prostate cancer published in English from 2008 to 2016. We reviewed these data and used narrative synthesis methods to integrate findings into a descriptive summary and identify research needs. We identified 27 relevant articles. Most focused on genetic testing for breast cancer (23/27) and colorectal cancer risk (12/27); only one study examined testing for prostate cancer risk. Most articles addressed descriptive research questions (24/27). Many studies (24/27) documented PCPs' knowledge, often concluding that providers' knowledge was incomplete. Studies commonly (11/27) examined PCPs' attitudes. Across studies, PCPs expressed some concerns about ethical, legal, and social implications of testing. Attitudes about the utility of clinical genetic testing, including for targeted cancer screening, were generally favorable; PCPs were more skeptical of direct-to-consumer testing. Relatively fewer studies (9/27) examined PCPs' communication practices regarding cancer genetic testing. This review indicates a need for investigators to move beyond descriptive research questions related to PCPs' knowledge and attitudes about cancer genetic testing. Research is needed to address important gaps regarding the development, testing, and implementation of innovative interventions and educational programs that can improve PCPs' genetic testing knowledge, assuage concerns about the appropriateness of cancer genetic testing, and promote open and effective patient-provider communication about genetic risk and genetic testing.

Advanced Motor Control Test Facility for NASA GRC Flywheel Energy Storage System Technology Development Unit

NASA Technical Reports Server (NTRS)

Kenny, Barbara H.; Kascak, Peter E.; Hofmann, Heath; Mackin, Michael; Santiago, Walter; Jansen, Ralph

2001-01-01

This paper describes the flywheel test facility developed at the NASA Glenn Research Center with particular emphasis on the motor drive components and control. A four-pole permanent magnet synchronous machine, suspended on magnetic bearings, is controlled with a field orientation algorithm. A discussion of the estimation of the rotor position and speed from a "once around signal" is given. The elimination of small dc currents by using a concurrent stationary frame current regulator is discussed and demonstrated. Initial experimental results are presented showing the successful operation and control of the unit at speeds up to 20,000 rpm.

Enhanced In-Pile Instrumentation at the Advanced Test Reactor

NASA Astrophysics Data System (ADS)

Rempe, Joy L.; Knudson, Darrell L.; Daw, Joshua E.; Unruh, Troy; Chase, Benjamin M.; Palmer, Joe; Condie, Keith G.; Davis, Kurt L.

2012-08-01

Many of the sensors deployed at materials and test reactors cannot withstand the high flux/high temperature test conditions often requested by users at U.S. test reactors, such as the Advanced Test Reactor (ATR) at the Idaho National Laboratory. To address this issue, an instrumentation development effort was initiated as part of the ATR National Scientific User Facility in 2007 to support the development and deployment of enhanced in-pile sensors. This paper provides an update on this effort. Specifically, this paper identifies the types of sensors currently available to support in-pile irradiations and those sensors currently available to ATR users. Accomplishments from new sensor technology deployment efforts are highlighted by describing new temperature and thermal conductivity sensors now available to ATR users. Efforts to deploy enhanced in-pile sensors for detecting elongation and real-time flux detectors are also reported, and recently-initiated research to evaluate the viability of advanced technologies to provide enhanced accuracy for measuring key parameters during irradiation testing are noted.

Cool-Down and Current Test Results of the KSTAR Prototype TF Coil

NASA Astrophysics Data System (ADS)

Oh, Y. K.; Lee, S.; Chu, Y.; Park, K. R.; Yonekawa, H.; Baek, S. H.; Cho, K. W.; Park, Y. M.; Kim, M. K.; Chang, H. S.; Kim, Y. S.; Chang, Y. B.; Lee, Y. J.; Kim, W. C.; Kim, K.; Kwag, S. W.; Lee, S. H.; Yang, S. H.; Lee, S. J.; Bak, J. S.; Lee, G. S.

2004-06-01

A prototype toroidal field (TF) coil, TF00 coil, of the Korea Superconducting Tokamak Advanced Research (KSTAR) project has been assembled and tested at the coil test facility in Korea Basic Science Institute (KBSI). The TF00 coil is a real-sized TF coil made of Nb3Sn superconducting cable-in-conduit conductor (CICC). The coil test was conducted by several campaigns according to the objectives. The first campaign, which was carried out by Jan. 2003, has objectives of cooling the coil into operating temperature and finding any defect in the coil such as cold leaks. From the results of the first campaign experiment, any defect in the coil was not found. The second campaign, which was carried out by Aug. 2003, has objectives to get the operating characteristics according to the current ramp up and discharge operations. In this paper, the coil test results are introduced as well as the details of the coil test system setup.

Testing the stress-gradient hypothesis during the restoration of tropical degraded land using the shrub Rhodomyrtus tomentosa as a nurse plant

Treesearch

Nan Liu; Hai Ren; Sufen Yuan; Qinfeng Guo; Long Yang

2013-01-01

The relative importance of facilitation and competition between pairwise plants across abiotic stress gradients as predicted by the stress-gradient hypothesis has been confirmed in arid and temperate ecosystems, but the hypothesis has rarely been tested in tropical systems, particularly across nutrient gradients. The current research examines the interactions between a...

Highlights of Conference on Using Student Test Scores to Measure Teacher Performance: The State of the Art in Research and Practice

ERIC Educational Resources Information Center

Guarino, Cassandra; Reckase, Mark D.; Wooldridge, Jeffrey M.

2013-01-01

The push for accountability in public schooling has extended to the measurement of teacher performance, accelerated by federal efforts through Race to the Top. Currently, a large number of states and districts across the country are computing measures of teacher performance based on the standardized test scores of their students and using them to…

Towards composition of verified hardware devices

NASA Technical Reports Server (NTRS)

Schubert, E. Thomas; Levitt, K.; Cohen, G. C.

1991-01-01

Computers are being used where no affordable level of testing is adequate. Safety and life critical systems must find a replacement for exhaustive testing to guarantee their correctness. Through a mathematical proof, hardware verification research has focused on device verification and has largely ignored system composition verification. To address these deficiencies, we examine how the current hardware verification methodology can be extended to verify complete systems.

Gigascale Silicon Research Center for Design and Test

DTIC Science & Technology

2000-01-07

students Kanna Shimizu and Chris Wilson participated in a meeting at Intel hosted by Mani Azimi, with Moenes, Ching-Tsun, Fred Rastgar, and Mani...Prof. David Dill Researchers: Kanna Shimizu Bus specifications are currently informal, resulting in ambiguities and inconsistencies. We’ve been...Expected Graduation: 6/1/2000 Advisor: Dill Last Name: Shimizu First Name: Kanna Work Address: Department of Computer Science, Gates Computer Science

A Comparative Test of Work-Family Conflict Models and Critical Examination of Work-Family Linkages

ERIC Educational Resources Information Center

Michel, Jesse S.; Mitchelson, Jacqueline K.; Kotrba, Lindsey M.; LeBreton, James M.; Baltes, Boris B.

2009-01-01

This paper is a comprehensive meta-analysis of over 20 years of work-family conflict research. A series of path analyses were conducted to compare and contrast existing work-family conflict models, as well as a new model we developed which integrates and synthesizes current work-family theory and research. This new model accounted for 40% of the…

Final Report: Continuation Study: A Systems Approach to Understanding Post-Traumatic Stress Disorder

DTIC Science & Technology

2017-01-31

Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 Post Traumatic Stress Disorder, HPA-Circadian-metabolic pathway, methylation...17150 remaining probes were located in coding regions. Linear additive models were used to test the interactions among the quantitative loci and...SECURITY CLASSIFICATION OF: Post -Traumatic Stress Disorder (PTSD) is a complex anxiety disorder affecting many combat-exposed soldiers. Current

Programmatic Research to Develop and Disseminate Improved Instructional Technology for Handicapped Children. Project MORE Quarterly Progress Report, September 1 to December 1, 1972.

ERIC Educational Resources Information Center

Schiefelbusch, Richard L.; Lent, James R.

During the past reporting period the curriculum development staff of Project MORE (Mediated Operational Research for Education) has made substantial progress in attaining its program objectives. Design and development phases have proceeded on schedule. Four programs are currently in the field-testing stage, and four others are under development.…

Marshall Space Flight Center's Impact Testing Facility Capabilities

NASA Technical Reports Server (NTRS)

Evans, Steve; Finchum, Andy; Hubbs, Whitney; Gray, Perry

2008-01-01

Marshall Space Flight Center's (MSFC) Impact Testing Facility (ITF) serves as an important installation for space and missile related materials science research. The ITF was established and began its research in spacecraft debris shielding in the early 1960s, then played a major role in the International Space Station debris shield development. As NASA became more interested in launch debris and in-flight impact concerns, the ITF grew to include research in a variety of impact genres. Collaborative partnerships with the DoD led to a wider range of impact capabilities being relocated to MSFC as a result of the closure of Particle Impact Facilities in Santa Barbara, California, The Particle Impact Facility had a 30 year history in providing evaluations of aerospace materials and components during flights through rain, ice, and solid particle environments at subsonic through hypersonic velocities. The facility's unique capabilities were deemed a 'National Asset' by the DoD, The ITF now has capabilities including environmental, ballistic, and hypervelocity impact testing utilizing an array of air, powder, and two-stage light gas guns to accommodate a variety of projectile and target types and sizes. Relocated test equipment was dated and in need of upgrade. Numerous upgrades including new instrumentation, triggering circuitry, high speed photography, and optimized sabot designs have been implemented. Other recent research has included rain drop demise characterization tests to obtain data for inclusion in on-going model development. Future ITF improvements will be focused on continued instrumentation and performance enhancements. These enhancements will allow further, more in-depth, characterization of rain drop demise characterization and evaluation of ice crystal impact. Performance enhancements also include increasing the upper velocity limit of the current environmental guns to allow direct environmental simulation for missile components. The current and proposed ITF capabilities range from rain to micrometeoroids allowing the widest test parameter range possible for materials investigations in support of space, atmospheric, and ground environments. These test capabilities including hydrometeor, single/multi-particle, ballistic gas guns, exploding wire gun, and light gas guns combined with Smooth Particle Hydrodynamics Code (SPHC) simulations represent the widest range of impact test capabilities in the country.

Marshall Space Flight Center's Impact Testing Facility Capabilities

NASA Technical Reports Server (NTRS)

Evans, Steve; Finchum, Andy; Hubbs, Whitney

2008-01-01

Marshall Space Flight Center's (MSFC) Impact Testing Facility (ITF) serves as an important installation for space and missile related materials science research. The ITF was established and began its research in spacecraft debris shielding in the early 1960% then played a major role in the International Space Station debris shield development. As NASA became more interested in launch debris and in-flight impact concerns, the ITF grew to include research in a variety of impact genres. Collaborative partnerships with the DoD led to a wider range of impact capabilities being relocated to MSFC as a result of the closure of Particle Impact Facilities in Santa Barbara, California. The Particle Impact Facility had a 30 year history in providing evaluations of aerospace materials and components during flights through rain, ice, and solid particle environments at subsonic through hypersonic velocities. The facility's unique capabilities were deemed a "National Asset" by the DoD. The ITF now has capabilities including environmental, ballistic, and hypervelocity impact testing utilizing an array of air, powder, and two-stage light gas guns to accommodate a variety of projectile and target types and sizes. Relocated test equipment was dated and in need of upgrade. Numerous upgrades including new instrumentation, triggering circuitry, high speed photography, and optimized sabot designs have been implemented. Other recent research has included rain drop demise characterization tests to obtain data for inclusion in on-going model development. Future ITF improvements will be focused on continued instrumentation and performance enhancements. These enhancements will allow further, more in-depth, characterization of rain drop demise characterization and evaluation of ice crystal impact. Performance enhancements also include increasing the upper velocity limit of the current environmental guns to allow direct environmental simulation for missile components. The current and proposed ITF capabilities range from rain to micrometeoroids allowing the widest test parameter range possible for materials investigations in support of space, atmospheric, and ground environments. These test capabilities including hydrometeor, single/multi-particle, ballistic gas grins, exploding wire gun, and light gas guns combined with Smooth Particle Hydrodynamics Code (SPHC) simulations represent the widest range of impact test capabilities in the country.

Specific Pathogen Free Macaque Colonies: A Review of Principles and Recent Advances for Viral Testing and Colony Management

PubMed Central

Yee, JoAnn L.; Vandeford, Thomas H.; Didier, Elizabeth S.; Gray, Stanton; Lewis, Anne; Roberts, Jeffrey; Taylor, Kerry; Bohm, Rudolf P.

2016-01-01

Specific Pathogen Free (SPF) macaques provide valuable animal models for biomedical research. In 1989 the National Center for Research Resources (now Office of Research Infrastructure Programs ORIP) of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilities management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making. PMID:26932456

Enhancing In-Flight Transoceanic Communications Using Swift-64 Packet Mode Service

NASA Technical Reports Server (NTRS)

Slywczak, Richard A.

2004-01-01

Current aeronautical communications can be divided into two segments. The first provides state of the art, packet switched technology to the cabin passengers so that they have access to e-mail and web services. The second provides basic circuit switch communication technology to the cockpit, which does not use bandwidth as efficiently as packet switching nor promotes resource sharing. This paper explores the research efforts currently being conducted by the NASA/Glenn Research Center (GRC) for transoceanic communications. The goal is to bring packet mode services to both the cabin and the cockpit of the aircraft and be able to attain benefits by sharing the data link with cabin services. First, this paper will outline the goals of the program and detail the benefits and issues related to this research. We will explain our current laboratory setup and show an architecture implemented in the testbed. Finally, we will present a work plan that will show the progression of research over the next year. This plan will describe a complete cycle from conceptual design and laboratory implementation to the final flight testing.

Polyurethane foam infill for fiber-reinforced polymer (FRP) bridge deck panels.

DOT National Transportation Integrated Search

2014-05-01

The objective of the proposed research is to develop, test, and evaluate fiber-reinforced, polyurethane foams to replace the costly : honeycomb construction currently used to manufacture FRP bridge deck panels. The effort will focus on developing an ...

About White Sands Missile Range

NASA Technical Reports Server (NTRS)

1991-01-01

Information on the White Sands Missile Range is given in viewgraph form. Navy programs, test sites, rocket programs, research rockets' booster capacity, current boost capabilities, ordnance and payload assembly areas, commercial space launch history and agreements, and lead times are among the topics covered.

MDOT innovation leading to faster, longer-lasting pavement repairs : research spotlight.

DOT National Transportation Integrated Search

2015-01-01

Current methods of patching pavement must evolve to meet increasing mobility demands. : To address this need, MDOT has been testing a new generation of rapid set full-depth : pavement repair materials. Initial results are promising. The new materials...

"High Stage" Organizing.

ERIC Educational Resources Information Center

Torbert, William R.

Although a psychological theory of stages of transformation in human development currently exists, organizational researchers have yet to elaborate and test any theory of organizational transformation of comparable elegance. According to the organizational stage theory being developed since 1974 by William Torbert, bureaucratic organization, which…

A 9700-hour durability test of a five centimeter diameter ion thruster

NASA Technical Reports Server (NTRS)

Nakanishi, S.; Finke, R. C.

1973-01-01

A modified Hughes SIT-5 thruster was life-tested at the Lewis Research Center. The final 2700 hours of the test are described with a charted history of thruster operating parameters and off-normal events. Performance and operating characteristics were nearly constant throughout the test except for neutralizer heater power requirements and accelerator drain current. A post-shutdown inspection revealed sputter erosion of ion chamber components and component flaking of sputtered metal. Several flakes caused beamlet divergence and anomalous grid erosion, causing the test to be terminated. All sputter erosion sources were identified.

Status report on Project Hercules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loree, D.; Giesselmann, M.; Kristiansen, M.

1993-01-01

Project Hercules is a project to improve ignitron switches which will then be used on the upgrade of Lawrence Livermore's Nova Laser for their ICF program. The goals of Hercules, which stands for High Energy Research Concerning the Ultimate Lifetime of Experimental Switches, are to lifetime test (up to 10,000 shots) prototype ignitrons or other switches with the required Nova current and coulomb parameters (300 kA, 200 C), recommend design changes, and retest the second generation switches. This report describes the design and construction of the test circuit and necessary diagnostics. The details of the design and construction of themore » test circuit and necessary diagnostics. The details of the design and construction of a 0.5 MJ electrolytic capacitor bank and a semi-automatic diagnostic/control system are described. The required test run data include peak current and corresponding tube voltage for every shot, entire current and voltage waveforms every few shots, and ignitor resistance values every few shots. Additionally, the conversion of a 120 kW, 12 kV constant voltage supply to an 8 A constant current supply with the use of six SCRs and a commercial control board will be described. The final results of this project will be lifetime data at high current and high coulomb for and improvements on some of the best of the new generation of pulsed power switches.« less

Regenerative Fuel Cell Test Rig at Glenn Research Center

NASA Technical Reports Server (NTRS)

Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.; Jakupca, Ian J.; Scullin, Vincent J.; Bents, David J.

2003-01-01

The regenerative fuel cell development effort at Glenn Research Center (GRC) involves the integration of a dedicated fuel cell and electrolyzer into an energy storage system test rig. The test rig consists of a fuel cell stack, an electrolysis stack, cooling pumps, a water transfer pump, gas recirculation pumps, phase separators, storage tanks for oxygen (O2) and hydrogen (H2), heat exchangers, isolation valves, pressure regulators, interconnecting tubing, nitrogen purge provisions, and instrumentation for control and monitoring purposes. The regenerative fuel cell (RFC) thus formed is a completely closed system which is capable of autonomous cyclic operation. The test rig provides direct current (DC) load and DC power supply to simulate power consumption and solar power input. In addition, chillers are used as the heat sink to dissipate the waste heat from the electrochemical stack operation. Various vents and nitrogen (N2) sources are included in case inert purging is necessary to safe the RFC test rig.

Observed Changes in As-Fabricated U-10Mo Monolithic Fuel Microstructures After Irradiation in the Advanced Test Reactor

NASA Astrophysics Data System (ADS)

Keiser, Dennis; Jue, Jan-Fong; Miller, Brandon; Gan, Jian; Robinson, Adam; Madden, James

2017-12-01

A low-enriched uranium U-10Mo monolithic nuclear fuel is being developed by the Material Management and Minimization Program, earlier known as the Reduced Enrichment for Research and Test Reactors Program, for utilization in research and test reactors around the world that currently use high-enriched uranium fuels. As part of this program, reactor experiments are being performed in the Advanced Test Reactor. It must be demonstrated that this fuel type exhibits mechanical integrity, geometric stability, and predictable behavior to high powers and high fission densities in order for it to be a viable fuel for qualification. This paper provides an overview of the microstructures observed at different regions of interest in fuel plates before and after irradiation for fuel samples that have been tested. These fuel plates were fabricated using laboratory-scale fabrication methods. Observations regarding how microstructural changes during irradiation may impact fuel performance are discussed.

Clinical trials transparency and the Trial and Experimental Studies Transparency (TEST) act.

PubMed

Logvinov, Ilana

2014-03-01

Clinical trial research is the cornerstone for successful advancement of medicine that provides hope for millions of people in the future. Full transparency in clinical trials may allow independent investigators to evaluate study designs, perform additional analysis of data, and potentially eliminate duplicate studies. Current regulatory system and publishers rely on investigators and pharmaceutical industries for complete and accurate reporting of results from completed clinical trials. Legislation seems to be the only way to enforce mandatory disclosure of results. The Trial and Experimental Studies Transparency (TEST) Act of 2012 was introduced to the legislators in the United States to promote greater transparency in research industry. Public safety and advancement of science are the driving forces for the proposed policy change. The TEST Act may benefit the society and researchers; however, there are major concerns with participants' privacy and intellectual property protection. Copyright © 2014 Elsevier Inc. All rights reserved.

A Combined Ethical and Scientific Analysis of Large-scale Tests of Solar Climate Engineering

NASA Astrophysics Data System (ADS)

Ackerman, T. P.

2017-12-01

Our research group recently published an analysis of the combined ethical and scientific issues surrounding large-scale testing of stratospheric aerosol injection (SAI; Lenferna et al., 2017, Earth's Future). We are expanding this study in two directions. The first is extending this same analysis to other geoengineering techniques, particularly marine cloud brightening (MCB). MCB has substantial differences to SAI in this context because MCB can be tested over significantly smaller areas of the planet and, following injection, has a much shorter lifetime of weeks as opposed to years for SAI. We examine issues such as the role of intent, the lesser of two evils, and the nature of consent. In addition, several groups are currently considering climate engineering governance tools such as a code of ethics and a registry. We examine how these tools might influence climate engineering research programs and, specifically, large-scale testing. The second direction of expansion is asking whether ethical and scientific issues associated with large-scale testing are so significant that they effectively preclude moving ahead with climate engineering research and testing. Some previous authors have suggested that no research should take place until these issues are resolved. We think this position is too draconian and consider a more nuanced version of this argument. We note, however, that there are serious questions regarding the ability of the scientific research community to move to the point of carrying out large-scale tests.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Selkirk, J.K.

The National Toxicology Program (NTP) was organized to support national public health programs by initiating research designed to understand the physiological, metabolic, and genetic basis for chemical toxicity. The primary mandated responsibilities of NTP were in vivo and vitro toxicity testing of potentially hazardous chemicals; broadening the spectrum of toxicological information on known hazardous chemicals; validating current toxicological assay systems as well as developing new and innovative toxicity testing technology; and rapidly communicating test results to government agencies with regulatory responsibilities and to the medical and scientific communities. 2 figs.

Simulation tests of the optimization method of Hopfield and Tank using neural networks

NASA Technical Reports Server (NTRS)

Paielli, Russell A.

1988-01-01

The method proposed by Hopfield and Tank for using the Hopfield neural network with continuous valued neurons to solve the traveling salesman problem is tested by simulation. Several researchers have apparently been unable to successfully repeat the numerical simulation documented by Hopfield and Tank. However, as suggested to the author by Adams, it appears that the reason for those difficulties is that a key parameter value is reported erroneously (by four orders of magnitude) in the original paper. When a reasonable value is used for that parameter, the network performs generally as claimed. Additionally, a new method of using feedback to control the input bias currents to the amplifiers is proposed and successfully tested. This eliminates the need to set the input currents by trial and error.

High Accuracy Temperature Measurements Using RTDs with Current Loop Conditioning

NASA Technical Reports Server (NTRS)

Hill, Gerald M.

1997-01-01

To measure temperatures with a greater degree of accuracy than is possible with thermocouples, RTDs (Resistive Temperature Detectors) are typically used. Calibration standards use specialized high precision RTD probes with accuracies approaching 0.001 F. These are extremely delicate devices, and far too costly to be used in test facility instrumentation. Less costly sensors which are designed for aeronautical wind tunnel testing are available and can be readily adapted to probes, rakes, and test rigs. With proper signal conditioning of the sensor, temperature accuracies of 0.1 F is obtainable. For reasons that will be explored in this paper, the Anderson current loop is the preferred method used for signal conditioning. This scheme has been used in NASA Lewis Research Center's 9 x 15 Low Speed Wind Tunnel, and is detailed.

A chemical sensor and biosensor based totally automated water quality monitor for extended space flight: Step 1

NASA Technical Reports Server (NTRS)

Smith, Robert S.

1993-01-01

The result of a literature search to consider what technologies should be represented in a totally automated water quality monitor for extended space flight is presented. It is the result of the first summer in a three year JOVE project. The next step will be to build a test platform at the Authors' school, St. John Fisher College. This will involve undergraduates in NASA related research. The test flow injection analysis system will be used to test the detection limit of sensors and the performance of sensors in groups. Sensor companies and research groups will be encouraged to produce sensors which are not currently available and are needed for this project.

Testing of Hypothesis in Equivalence and Non Inferiority Trials-A Concept.

PubMed

Juneja, Atul; Aggarwal, Abha R; Adhikari, Tulsi; Pandey, Arvind

2016-04-01

Establishing the appropriate hypothesis is one of the important steps for carrying out the statistical tests/analysis. Its understanding is important for interpreting the results of statistical analysis. The current communication attempts to provide the concept of testing of hypothesis in non inferiority and equivalence trials, where the null hypothesis is just reverse of what is set up for conventional superiority trials. It is similarly looked for rejection for establishing the fact the researcher is intending to prove. It is important to mention that equivalence or non inferiority cannot be proved by accepting the null hypothesis of no difference. Hence, establishing the appropriate statistical hypothesis is extremely important to arrive at meaningful conclusion for the set objectives in research.

The NASA Lewis Research Center Water Tunnel Facility

NASA Technical Reports Server (NTRS)

Wasserbauer, Charles A.

1997-01-01

A water tunnel facility specifically designed to investigate internal fluid duct flows has been built at the NASA Research Center. It is built in a modular fashion so that a variety of internal flow test hardware can be installed in the facility with minimal facility reconfiguration. The facility and test hardware interfaces are discussed along with design constraints for future test hardware. The inlet chamber flow conditioning approach is also detailed. Instrumentation and data acquisition capabilities are discussed. The incoming flow quality has been documented for about one quarter of the current facility operating range. At that range, there is some scatter in the data in the turbulent boundary layer which approaches 10 percent of the duct radius leading to a uniform core.

Integrating Clinical Services for HIV, Tuberculosis, and Cryptococcal Disease in the Developing World: A Step Forward with 2 Novel Diagnostic Tests

PubMed Central

Vijayan, Tara; Klausner, Jeffrey D.

2014-01-01

The success of antiretroviral therapy (ART) programs in the developing world is limited by the lack of adequate diagnostic tests to screen for life-threatening opportunistic infections such as tuberculosis (TB) and cryptococcal disease. Furthermore, there is an increasing need for implementation research in measuring the effectiveness of currently available rapid diagnostic tests. The recently developed lateral flow assays for both cryptococcal disease and TB have the potential to improve care and greatly reduce the time to initiation of ART among individuals who need it the most. However, we caution that the data on feasibility and effectiveness of these assays are limited and such research agendas must be prioritized. PMID:24065780

Testing Conducted for Lithium-Ion Cell and Battery Verification

NASA Technical Reports Server (NTRS)

Reid, Concha M.; Miller, Thomas B.; Manzo, Michelle A.

2004-01-01

The NASA Glenn Research Center has been conducting in-house testing in support of NASA's Lithium-Ion Cell Verification Test Program, which is evaluating the performance of lithium-ion cells and batteries for NASA mission operations. The test program is supported by NASA's Office of Aerospace Technology under the NASA Aerospace Flight Battery Systems Program, which serves to bridge the gap between the development of technology advances and the realization of these advances into mission applications. During fiscal year 2003, much of the in-house testing effort focused on the evaluation of a flight battery originally intended for use on the Mars Surveyor Program 2001 Lander. Results of this testing will be compared with the results for similar batteries being tested at the Jet Propulsion Laboratory, the Air Force Research Laboratory, and the Naval Research Laboratory. Ultimately, this work will be used to validate lithium-ion battery technology for future space missions. The Mars Surveyor Program 2001 Lander battery was characterized at several different voltages and temperatures before life-cycle testing was begun. During characterization, the battery displayed excellent capacity and efficiency characteristics across a range of temperatures and charge/discharge conditions. Currently, the battery is undergoing lifecycle testing at 0 C and 40-percent depth of discharge under low-Earth-orbit (LEO) conditions.

Analytical and physical modeling program for the NASA Lewis Research Center's Altitude Wind Tunnel (AWT)

NASA Technical Reports Server (NTRS)

Abbott, J. M.; Deidrich, J. H.; Groeneweg, J. F.; Povinelli, L. A.; Reid, L.; Reinmann, J. J.; Szuch, J. R.

1985-01-01

An effort is currently underway at the NASA Lewis Research Center to rehabilitate and extend the capabilities of the Altitude Wind Tunnel (AWT). This extended capability will include a maximum test section Mach number of about 0.9 at an altitude of 55,000 ft and a -20 F stagnation temperature (octagonal test section, 20 ft across the flats). In addition, the AWT will include an icing and acoustic research capability. In order to insure a technically sound design, an AWT modeling program (both analytical and physical) was initiated to provide essential input to the AWT final design process. This paper describes the modeling program, including the rationale and criteria used in program definition, and presents some early program results.

Test Method Designed to Evaluate Cylinder Liner-Piston Ring Coatings for Advanced Heat Engines

NASA Technical Reports Server (NTRS)

Radil, Kevin C.

1997-01-01

Research on advanced heat engine concepts, such as the low-heat-rejection engine, have shown the potential for increased thermal efficiency, reduced emissions, lighter weight, simpler design, and longer life in comparison to current diesel engine designs. A major obstacle in the development of a functional advanced heat engine is overcoming the problems caused by the high combustion temperatures at the piston ring/cylinder liner interface, specifically at top ring reversal (TRR). Therefore, advanced cylinder liner and piston ring materials are needed that can survive under these extreme conditions. To address this need, researchers at the NASA Lewis Research Center have designed a tribological test method to help evaluate candidate piston ring and cylinder liner materials for advanced diesel engines.

IOTA (Integrable Optics Test Accelerator): facility and experimental beam physics program

NASA Astrophysics Data System (ADS)

Antipov, S.; Broemmelsiek, D.; Bruhwiler, D.; Edstrom, D.; Harms, E.; Lebedev, V.; Leibfritz, J.; Nagaitsev, S.; Park, C. S.; Piekarz, H.; Piot, P.; Prebys, E.; Romanov, A.; Ruan, J.; Sen, T.; Stancari, G.; Thangaraj, C.; Thurman-Keup, R.; Valishev, A.; Shiltsev, V.

2017-03-01

The Integrable Optics Test Accelerator (IOTA) is a storage ring for advanced beam physics research currently being built and commissioned at Fermilab. It will operate with protons and electrons using injectors with momenta of 70 and 150 MeV/c, respectively. The research program includes the study of nonlinear focusing integrable optical beam lattices based on special magnets and electron lenses, beam dynamics of space-charge effects and their compensation, optical stochastic cooling, and several other experiments. In this article, we present the design and main parameters of the facility, outline progress to date and provide the timeline of the construction, commissioning and research. The physical principles, design, and hardware implementation plans for the major IOTA experiments are also discussed.

Evaluation of High Temperature Knitted Spring Tubes for Structural Seal Applications

NASA Technical Reports Server (NTRS)

Taylor, Shawn C.; DeMange, Jeffrey J.; Dunlap, Patrick H., Jr.; Steinetz, Bruce M.

2004-01-01

Control surface seals are crucial to current and future space vehicles, as they are used to seal the gaps surrounding body flaps, elevons, and other actuated exterior surfaces. During reentry, leakage of high temperature gases through these gaps could damage underlying lower temperature structures such as rudder drive motors and mechanical actuators, resulting in impaired vehicle control. To be effective, control surface seals must shield lower temperature structures from heat transfer by maintaining sufficient resiliency to remain in contact with opposing sealing surfaces through multiple compression cycles. The current seal exhibits significant loss of resiliency after a few compression cycles at elevated temperatures (i.e., 1900 F) and therefore would be inadequate for advanced space vehicles. This seal utilizes a knitted Inconel X-750 spring tube as its primary resilient element. As part of a larger effort to enhance seal resiliency, researchers at the NASA Glenn Research Center performed high temperature compression testing (up to 2000 F) on candidate spring tube designs employing material substitutions and modified geometries. These tests demonstrated significant improvements in spring tube resiliency (5.5x better at 1750 F) through direct substitution of heat treated Rene 41 alloy in the baseline knit design. The impact of geometry modification was minor within the range of parameters tested, however trends did suggest that moderate resiliency improvements could be obtained by optimizing the current spring tube geometry.

Characterization of viscoelastic materials for low-magnitude blast mitigation

NASA Astrophysics Data System (ADS)

Bartyczak, S.; Mock, W.

2014-05-01

Recent research indicates that exposure to low amplitude blast waves, such as IED detonation or multiple firings of a weapon, causes damage to brain tissue resulting in Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD). Current combat helmets are not sufficiently protecting warfighters from this danger and the effects are debilitating, costly, and long-lasting. The objective of the present work is to evaluate the blast mitigating behavior of current helmet materials and new materials designed for blast mitigation using a test fixture recently developed at the Naval Surface Warfare Center Dahlgren Division for use with an existing gas gun. The 40-mm-bore gas gun was used as a shock tube to generate blast waves (ranging from 0.5 to 2 bar) in the test fixture mounted on the gun muzzle. A fast opening valve was used to release helium gas from the breech which formed into a blast wave and impacted instrumented targets in the test fixture. Blast attenuation of selected materials was determined through the measurement of stress data in front of and behind the target. Materials evaluated in this research include polyurethane foam from currently fielded US Army and Marine Corps helmets, polyurea 1000, and three hardnesses of Sorbothane (48, 58, and 70 durometer, Shore 00). Polyurea 1000 and 6061-T6 aluminum were used to calibrate the stress gauges.

A low-cost touchscreen operant chamber using a Raspberry Pi™.

PubMed

O'Leary, James D; O'Leary, Olivia F; Cryan, John F; Nolan, Yvonne M

2018-03-08

The development of a touchscreen platform for rodent testing has allowed new methods for cognitive testing that have been back-translated from clinical assessment tools to preclinical animal models. This platform for cognitive assessment in animals is comparable to human neuropsychological tests such as those employed by the Cambridge Neuropsychological Test Automated Battery, and thus has several advantages compared to the standard maze apparatuses typically employed in rodent behavioral testing, such as the Morris water maze. These include improved translation of preclinical models, as well as high throughput and the automation of animal testing. However, these systems are relatively expensive, which can impede progress for researchers with limited resources. Here we describe a low-cost touchscreen operant chamber based on the single-board computer, Raspberry Pi TM , which is capable of performing tasks similar to those supported by current state-of-the-art systems. This system provides an affordable alternative for cognitive testing in a touchscreen operant paradigm for researchers with limited funding.

Military chemical warfare agent human subjects testing: part 1--history of six-decades of military experiments with chemical warfare agents.

PubMed

Brown, Mark

2009-10-01

Military chemical warfare agent testing from World War I to 1975 produced thousands of veterans with concerns of possible long-term health consequences. Clinical and research evaluation of potential long-term health effects has been difficult because the exposures occurred decades ago, the identity of troops exposed and exposure magnitudes are uncertain, and acute effects during experiments poorly documented. In contrast, a companion article describes the large amount of information available about the specific agents tested and their long-term health effects. This short history describes U.S. military chemical-agent experiments with human subjects and identifies tested agents. Finally, the demonstrated need to anticipate future health concerns from military personnel involved in such military testing suggests current and future military researchers should be required, by law and regulation, to fully record the identity of those exposed, relevant exposure magnitude, and complete medical information for all subjects. New study protocols and institutional review board approvals for research involving military personnel should reflect this need.

What do Key Stakeholders Think About HIV Self-Testing in Canada? Results from a Cross-Sectional Survey.

PubMed

Pai, N Pant; Smallwood, M; Gulati, D; Lapczak, N; Musten, A; Gaydos, C; Johnston, C; Steben, M; Wong, T; Engel, N; Kim, J

2018-02-01

Human immunodeficiency virus (HIV) self-testing presents an empowering alternative to facility-based testing for reaching undiagnosed HIV infected individuals, but is not currently available in Canada. We surveyed stakeholders (clinical providers, public health professionals, researchers) engaged in HIV testing initiatives nationwide to identify the concerns, opportunities and challenges to implementing HIV self-testing in Canada. An online cross-sectional survey was disseminated by the Canadian Institutes of Health Research Centre for REACH 2.0 National HIV & sexually transmitted and blood borne infections working group to stakeholders nationwide, with a target sample size of 200. Quantitative and qualitative data were analyzed using a mixed-methods, respondent-informed approach, to inform subsequent HIV self-testing in a country where self-testing is not yet accessible. A total of 183 responses were received. A majority (70.7%) (128/181) felt that self-testing was a necessary investment to reach the undiagnosed. 64.6% (117/181) felt that self-tests should be made available to their clients and 71.5% (128/179) of respondents agreed that self-test instructions required improvements. However, 50% (90/180) felt that self-testing will pose an economic challenge to current HIV testing models. Regardless, 21% urged for timely action and availability of HIV self-tests. Thematic analyses reflected the following concerns: (a) need for affordable self-tests, (b) need for expedited, customized, and accessible linkages to counselling, (c) concern for patients to cope with positive self-test results, (d) accuracy of self-tests to detect acute HIV and (e) liability in the context of non-disclosure. Stakeholders agreed to the provision of an option of HIV self-testing to reach the undiagnosed individuals. Concerns regarding costs and accuracy of self-tests, expedited linkages to counselling, and integration of self-test within prevailing HIV testing models, will need to be addressed before their widespread implementation.

When to start paediatric testing of the adult HIV cure research agenda?

PubMed

Shah, Seema K

2017-02-01

Ethical guidelines recommend that experimental interventions should be tested in adults first before they are tested and approved in children. Some challenge this paradigm, however, and recommend initiating paediatric testing after preliminary safety testing in adults in certain cases. For instance, commentators have argued for accelerated testing of HIV vaccines in children. Additionally, HIV cure research on the use of very early therapy (VET) in infants, prompted in part by the Mississippi baby case, is one example of a strategy that is currently being tested in infants before it has been well tested in adults. Because infants' immune systems are still developing, the timing of HIV transmission is easier to identify in infants than in adults, and infants who receive VET might never develop the viral reservoirs that make HIV so difficult to eradicate, infants may be uniquely situated to achieve HIV cure or sustained viral remission. Several commentators have now argued for earlier initiation of HIV cure interventions other than (or in addition to) VET in children. HIV cure research is therefore a good case for re-examining the important question of when to initiate paediatric research. I will argue that, despite the potential for HIV cure research to benefit children and the scientific value of involving children in this research, the HIV cure agenda should not accelerate the involvement of children for the following reasons: HIV cure research is highly speculative, risky, aimed at combination approaches and does not compare favourably with the available alternatives. I conclude by drawing general implications for the initiation of paediatric testing, including that interventions that have to be used in combination with others and cures for chronic diseases may not be valuable enough to justify early paediatric testing. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Testing the effects of social anxiety disorder on friendship quality across gender and ethnicity.

PubMed

Rodebaugh, Thomas L; Fernandez, Katya C; Levinson, Cheri A

2012-01-01

Previous research suggests that social anxiety disorder (SAD) has a specific relationship with impairment in friendship quality; however, potential moderators of this relationship have not been tested. The current study examines whether the specific effect of SAD on friendship quality is stable or varies across gender and ethnicity in a large epidemiological dataset. Results indicate that the underlying construct of friendship quality differed slightly but significantly between men and women; as a result, effects of SAD were tested in men and women separately. After partially constraining friendship quality across ethnic groups, our results indicated that the relationship between SAD and friendship quality remained robust in all groups. In addition to replicating the finding that SAD specifically relates to perceived friendship quality, the current study highlights the need to test whether underlying constructs such as friendship quality are consistent across the groups that make up heterogeneous samples.

Magnetic Excitation for Spin Vibration Testing

NASA Technical Reports Server (NTRS)

Johnson, Dexter; Mehmed, Oral; Brown, Gerald V.

1997-01-01

The Dynamic Spin Rig Laboratory (DSRL) at the NASA Lewis Research Center is a facility used for vibration testing of structures under spinning conditions. The current actuators used for excitation are electromagnetic shakers which are configured to apply torque to the rig's vertical rotor. The rotor is supported radially and axially by conventional bearings. Current operation is limited in rotational speed, excitation capability, and test duration. In an effort to enhance its capabilities, the rig has been initially equipped with a radial magnetic bearing which provides complementary excitation and shaft support. The new magnetic feature has been used in actual blade vibration tests and its performance has been favorable. Due to the success of this initial modification further enhancements are planned which include making the system fully magnetically supported. This paper reports on this comprehensive effort to upgrade the DSRL with an emphasis on the new magnetic excitation capability.

Handling Ibuprofen Increases Pain Tolerance and Decreases Perceived Pain Intensity in a Cold Pressor Test

PubMed Central

Rutchick, Abraham M.; Slepian, Michael L.

2013-01-01

Pain contributes to health care costs, missed work and school, and lower quality of life. Extant research on psychological interventions for pain has focused primarily on developing skills that individuals can apply to manage their pain. Rather than examining internal factors that influence pain tolerance (e.g., pain management skills), the current work examines factors external to an individual that can increase pain tolerance. Specifically, the current study examined the nonconscious influence of exposure to meaningful objects on the perception of pain. Participants (N = 54) completed a cold pressor test, examined either ibuprofen or a control object, then completed another cold pressor test. In the second test, participants who previously examined ibuprofen reported experiencing less intense pain and tolerated immersion longer (relative to baseline) than those who examined the control object. Theoretical and applied implications of these findings are discussed. PMID:23469170

First test of BNL electron beam ion source with high current density electron beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pikin, Alexander, E-mail: pikin@bnl.gov; Alessi, James G., E-mail: pikin@bnl.gov; Beebe, Edward N., E-mail: pikin@bnl.gov

A new electron gun with electrostatic compression has been installed at the Electron Beam Ion Source (EBIS) Test Stand at BNL. This is a collaborative effort by BNL and CERN teams with a common goal to study an EBIS with electron beam current up to 10 A, current density up to 10,000 A/cm{sup 2} and energy more than 50 keV. Intensive and pure beams of heavy highly charged ions with mass-to-charge ratio < 4.5 are requested by many heavy ion research facilities including NASA Space Radiation Laboratory (NSRL) at BNL and HIE-ISOLDE at CERN. With a multiampere electron gun, themore » EBIS should be capable of delivering highly charged ions for both RHIC facility applications at BNL and for ISOLDE experiments at CERN. Details of the electron gun simulations and design, and the Test EBIS electrostatic and magnetostatic structures with the new electron gun are presented. The experimental results of the electron beam transmission are given.« less

The pathway to earthquake early warning in the US

NASA Astrophysics Data System (ADS)

Allen, R. M.; Given, D. D.; Heaton, T. H.; Vidale, J. E.; West Coast Earthquake Early Warning Development Team

2013-05-01

The development of earthquake early warning capabilities in the United States is now accelerating and expanding as the technical capability to provide warning is demonstrated and additional funding resources are making it possible to expand the current testing region to the entire west coast (California, Oregon and Washington). Over the course of the next two years we plan to build a prototype system that will provide a blueprint for a full public system in the US. California currently has a demonstrations warning system, ShakeAlert, that provides alerts to a group of test users from the public and private sector. These include biotech companies, technology companies, the entertainment industry, the transportation sector, and the emergency planning and response community. Most groups are currently in an evaluation mode, receiving the alerts and developing protocols for future response. The Bay Area Rapid Transit (BART) system is the one group who has now implemented an automated response to the warning system. BART now stops trains when an earthquake of sufficient size is detected. Research and development also continues to develop improved early warning algorithms to better predict the distribution of shaking in large earthquakes when the finiteness of the source becomes important. The algorithms under development include the use of both seismic and GPS instrumentation and integration with existing point source algorithms. At the same time, initial testing and development of algorithms in and for the Pacific Northwest is underway. In this presentation we will review the current status of the systems, highlight the new research developments, and lay out a pathway to a full public system for the US west coast. The research and development described is ongoing at Caltech, UC Berkeley, University of Washington, ETH Zurich, Southern California Earthquake Center, and the US Geological Survey, and is funded by the Gordon and Betty Moore Foundation and the US Geological Survey.

Ego Depletion in Real-Time: An Examination of the Sequential-Task Paradigm.

PubMed

Arber, Madeleine M; Ireland, Michael J; Feger, Roy; Marrington, Jessica; Tehan, Joshua; Tehan, Gerald

2017-01-01

Current research into self-control that is based on the sequential task methodology is currently at an impasse. The sequential task methodology involves completing a task that is designed to tax self-control resources which in turn has carry-over effects on a second, unrelated task. The current impasse is in large part due to the lack of empirical research that tests explicit assumptions regarding the initial task. Five studies test one key, untested assumption underpinning strength (finite resource) models of self-regulation: Performance will decline over time on a task that depletes self-regulatory resources. In the aftermath of high profile replication failures using a popular letter-crossing task and subsequent criticisms of that task, the current studies examined whether depletion effects would occur in real time using letter-crossing tasks that did not invoke habit-forming and breaking, and whether these effects were moderated by administration type (paper and pencil vs. computer administration). Sample makeup and sizes as well as response formats were also varied across the studies. The five studies yielded a clear and consistent pattern of increasing performance deficits (errors) as a function of time spent on task with generally large effects and in the fifth study the strength of negative transfer effects to a working memory task were related to individual differences in depletion. These results demonstrate that some form of depletion is occurring on letter-crossing tasks though whether an internal regulatory resource reservoir or some other factor is changing across time remains an important question for future research.

Ego Depletion in Real-Time: An Examination of the Sequential-Task Paradigm

PubMed Central

Arber, Madeleine M.; Ireland, Michael J.; Feger, Roy; Marrington, Jessica; Tehan, Joshua; Tehan, Gerald

2017-01-01

Current research into self-control that is based on the sequential task methodology is currently at an impasse. The sequential task methodology involves completing a task that is designed to tax self-control resources which in turn has carry-over effects on a second, unrelated task. The current impasse is in large part due to the lack of empirical research that tests explicit assumptions regarding the initial task. Five studies test one key, untested assumption underpinning strength (finite resource) models of self-regulation: Performance will decline over time on a task that depletes self-regulatory resources. In the aftermath of high profile replication failures using a popular letter-crossing task and subsequent criticisms of that task, the current studies examined whether depletion effects would occur in real time using letter-crossing tasks that did not invoke habit-forming and breaking, and whether these effects were moderated by administration type (paper and pencil vs. computer administration). Sample makeup and sizes as well as response formats were also varied across the studies. The five studies yielded a clear and consistent pattern of increasing performance deficits (errors) as a function of time spent on task with generally large effects and in the fifth study the strength of negative transfer effects to a working memory task were related to individual differences in depletion. These results demonstrate that some form of depletion is occurring on letter-crossing tasks though whether an internal regulatory resource reservoir or some other factor is changing across time remains an important question for future research. PMID:29018390

Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response.

PubMed

Tenke, Craig E; Kayser, Jürgen; Pechtel, Pia; Webb, Christian A; Dillon, Daniel G; Goer, Franziska; Murray, Laura; Deldin, Patricia; Kurian, Benji T; McGrath, Patrick J; Parsey, Ramin; Trivedi, Madhukar; Fava, Maurizio; Weissman, Myrna M; McInnis, Melvin; Abraham, Karen; E Alvarenga, Jorge; Alschuler, Daniel M; Cooper, Crystal; Pizzagalli, Diego A; Bruder, Gerard E

2017-01-01

Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty-nine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60-100 dB SPL). Principal components analysis of current source density waveforms reduced volume conduction and provided reference-free measures of resting EEG alpha and N1 dipole activity to tones from auditory cortex. Low-resolution electromagnetic tomography (LORETA) extracted resting theta current density measures corresponding to rostral anterior cingulate (rACC), which has been implicated in treatment response. There were no significant differences in posterior alpha, N1 dipole, or rACC theta across sessions. Test-retest reliability was .84 for alpha, .87 for N1 dipole, and .70 for theta rACC current density. The demonstration of good-to-excellent reliability for these measures provides a template for future EEG/ERP studies from multiple testing sites, and an important step for evaluating them as biomarkers for predicting treatment response. © 2016 Society for Psychophysiological Research.

[Formula: see text]Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries.

PubMed

Semrud-Clikeman, Margaret; Romero, Regilda Anne A; Prado, Elizabeth L; Shapiro, Elsa G; Bangirana, Paul; John, Chandy C

2017-10-01

Diseases affecting millions of children in low- and middle-income countries (LMICs), such as malnutrition, micronutrient deficiency, malaria, and HIV, can lead to adverse neurodevelopmental outcomes. Thus, a key health outcome in children is neurodevelopmental status. In this paper, the neurodevelopmental screening and testing measures most commonly utilized in LMICs are reviewed, and a matrix is presented to help researchers and clinicians determine which measures may be most useful for various LMIC inquiries. The matrix is based on an Internet literature review of 114 publications for the period January 1998 to February 2016, reporting the psychometric properties of instruments tested in LMIC children. The measures are classified as screening tests or more detailed tests that include both comprehensive batteries of general development and tests of specific domains. For completeness, two experts have reviewed this paper, as well as the authors. An overview of the tests used to date is presented, including the benefits and drawbacks of each test, in order to provide researchers and developmental clinicians with a way to decide which tests may be best suited to their developmental assessment goals. Remarkable progress has been made in neurodevelopmental testing in children in LMICs over the past two decades but there remains a need for additional research in this area to develop new tests, better evaluate and adapt current tests, and assess test validity and reliability across cultures.

Descriptive Summaries of the Research Development Test & Evaluation Army Appropriation FY 1983. Supporting Data FY 1983, Budget Estimate Submitted to Congress February 1982. Volume III.

DTIC Science & Technology

1982-02-01

11-17 TACTICAL PROGRAMS 2.37.24.A HEAVY ANTITAIg/ASSAULT WEAPON SYSTEM (TOW...AIRBORNE,4) DIO SYSTEM (SINCGARS)................................ 11-328 6.37.47.A SOLDIER SUPPORT/SURVIVABILITY...enhanced illumination over the current 81mm mortar. The current smoke cartridges for the 81mm mortar and 4.2" battalion heavy mortar, in use since the

Terminal Area Productivity Program: Dynamic Spacing Human Factors

NASA Technical Reports Server (NTRS)

Kanki, Barbara G.

1997-01-01

Dynamic spacing human factors deals with the following human factors issues: define controller limits to incorporating dynamic changes in separation standards; identify timing, planning, and coordination strategies; and consider consistency with current practices, policies, and regulations. The AVOSS technologies will make it possible to reduce separation standards in the terminal area under certain meteorological conditions. This paper contains the following sections: Dynamic space human factors overview, Preliminary tests, and current research status & plans.

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

PubMed Central

Menard, Jean-Pierre

2011-01-01

Bacterial vaginosis is a common cause of malodorous vaginal discharge. It is also associated with sexually transmitted infections and adverse pregnancy outcomes. The magnitude of the gynecological and obstetrical consequences has stimulated therapeutic research and led to the testing of several therapies. The objective of this work is to present the currently available therapeutic strategies for the treatment of bacterial vaginosis and associated recommendations, and discuss the emerging therapies. PMID:21976983

Multilevel Research and the Challenges of Implementing Genomic Medicine

PubMed Central

Coates, Ralph J.; Fennell, Mary L.; Glasgow, Russell E.; Scheuner, Maren T.; Schully, Sheri D.; Williams, Marc S.; Clauser, Steven B.

2012-01-01

Advances in genomics and related fields promise a new era of personalized medicine in the cancer care continuum. Nevertheless, there are fundamental challenges in integrating genomic medicine into cancer practice. We explore how multilevel research can contribute to implementation of genomic medicine. We first review the rapidly developing scientific discoveries in this field and the paucity of current applications that are ready for implementation in clinical and public health programs. We then define a multidisciplinary translational research agenda for successful integration of genomic medicine into policy and practice and consider challenges for successful implementation. We illustrate the agenda using the example of Lynch syndrome testing in newly diagnosed cases of colorectal cancer and cascade testing in relatives. We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum. PMID:22623603

Multilevel research and the challenges of implementing genomic medicine.

PubMed

Khoury, Muin J; Coates, Ralph J; Fennell, Mary L; Glasgow, Russell E; Scheuner, Maren T; Schully, Sheri D; Williams, Marc S; Clauser, Steven B

2012-05-01

Advances in genomics and related fields promise a new era of personalized medicine in the cancer care continuum. Nevertheless, there are fundamental challenges in integrating genomic medicine into cancer practice. We explore how multilevel research can contribute to implementation of genomic medicine. We first review the rapidly developing scientific discoveries in this field and the paucity of current applications that are ready for implementation in clinical and public health programs. We then define a multidisciplinary translational research agenda for successful integration of genomic medicine into policy and practice and consider challenges for successful implementation. We illustrate the agenda using the example of Lynch syndrome testing in newly diagnosed cases of colorectal cancer and cascade testing in relatives. We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum.

Promotion of research on in vitro immunotoxicology.

PubMed

Balls, M; Sabbioni, E

2001-04-10

ECVAM was established to play a leading role at the European level in the independent evaluation of the reliability and relevance of test methods and testing strategies for specific purposes through research on advanced methods and new test development and validation, so that chemicals and products of various kinds, including medicines, vaccines, medical devices, cosmetics, household products and agricultural products, can be manufactured, transported and used more economically and more safely, whilst the current relevance on animal test procedures is progressively reduced. Nowhere is this activity more necessary than in the field of immunotoxicology, where we know that chemicals and products of many kinds have the potential to stimulate, modulate or suppress the induction or expression of various types of immune responses. The problem is to effectively evaluate the potency of these effectors, and, since the available information is currently based on rather qualitative animal tests, to evaluate the true relevance of this knowledge and apply it intelligently in risk assessment processes which will protect human beings without unnecessarily limiting the development and use of materials which otherwise have economic, health and social benefits. The way forward must depend on the following: (a) a better understanding of immunotoxicological processes, based on a sounder understanding of the immune system itself (and of its network of control systems and interrelationships with other body systems); (b) The use of in vitro (not in vivo) systems based on human (not animal) cells and tissues; (c) integrated and tiered testing strategies, incorporating QSAR, as well as in vitro approaches; (d) taking advantage of the use of cells or factors from humans who have been exposed to potential immunotoxins, be this voluntarily, occupationally, environmentally or by accident; and (e) the recognition that virtually everything will effect one or more aspects of the immune system at some dose level and, in some circumstances, deciding when such effects are relevant, is the key to immunotoxicity testing. Some current ECVAM-sponsored work and activities at ECVAM are described.

Gaining a Competitive Edge through Action Design Research

NASA Astrophysics Data System (ADS)

Alexa, L.; Alexa, M.; Avasilcăi, S.

2016-08-01

The current business environment is characterized by increased competition and highly innovative approach, in order to create products and services to better respond to the costumers’ needs and expectations. In this specific context, the research approaches need to be more flexible and business oriented and so, throughout the paper we have used a research method that combines design research and action research, named Action Design Research which is a research method used for generating prescriptive design knowledge through building and evaluating IT artifacts in an organizational setting [1]. Following the Action Design Research stages and principles: problem identification, building, intervention and evaluation, reflection and learning and formalization of learning, the research team has developed an online instrument used to actively involve the consumer in the product development process, in order to generate a better consumers insight regarding their needs and desires and to design and/or adjust the product accordingly. The customer engagement IT tool created and tested by using Action Design Research, E-PICUS, has been developed within the framework of the research project „E-solutions for innovation through customer pro-active involvement in value creation to increase organisational competitiveness (E-PICUS)”, PN- II-PT-PCCA-2013-4-1811, currently undergoing.

Physics and technology in the ion-cyclotron range of frequency on Tore Supra and TITAN test facility: implication for ITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litaudon, X; Bernard, J. M.; Colas, L.

2013-01-01

To support the design of an ITER ion-cyclotron range of frequency heating (ICRH) system and to mitigate risks of operation in ITER, CEA has initiated an ambitious Research & Development program accompanied by experiments on Tore Supra or test-bed facility together with a significant modelling effort. The paper summarizes the recent results in the following areas: Comprehensive characterization (experiments and modelling) of a new Faraday screen concept tested on the Tore Supra antenna. A new model is developed for calculating the ICRH sheath rectification at the antenna vicinity. The model is applied to calculate the local heat flux on Toremore » Supra and ITER ICRH antennas. Full-wave modelling of ITER ICRH heating and current drive scenarios with the EVE code. With 20 MW of power, a current of 400 kA could be driven on axis in the DT scenario. Comparison between DT and DT(3He) scenario is given for heating and current drive efficiencies. First operation of CW test-bed facility, TITAN, designed for ITER ICRH components testing and could host up to a quarter of an ITER antenna. R&D of high permittivity materials to improve load of test facilities to better simulate ITER plasma antenna loading conditions.« less

A Review of Recent RLV Research Activities in Japan

NASA Astrophysics Data System (ADS)

Sasaki, Makoto; Watanabe, Atsutaro

2004-02-01

Researches on reusable launch vehicle (RLV) in Japan have been conducted mainly by the three space agencies: the National Space Development Agency of Japan (NASDA), the National Aerospace Laboratory of Japan (NAL) and the Institute of Space and Astronautical Science (ISAS). HOPE-X program by NASDA/NAL, spaceplane/scramjet related researches by NAL, and development studies of ATREX engine and small reusable vehicle testing (RVT) by ISAS are such major activities. After the consecutive launch failures of NASDA's H-II and ISAS's M-V rockets in 1999-2000, it was concluded that more intensive efforts should be concentrated on the reliability improvement of those major expendable vehicles and that RLV related researches should be promoted to establish fundamental technologies essential to future RLV. In past two years, NASDA succeeded in five consecutive launches of new H-IIA, and ISAS successfully resumed the launch of M-V. As for RLV researches, considerable progress has been achieved in the high speed flight demonstration (HSFD) tests of HOPE-X program, scramjet tests of Mach 4 to 8 by NAL, and ATREX engine and small RVT tests by ISAS. The current three space agencies will be merged into one in October 2003 to establish a new organization named Japan Aerospace Exploration Agency (JAXA). It is expected that the above research activities will be also merged to promote a higher-level research program on RLV.

Integrating Professional Development across the Curriculum: An Effectiveness Study

ERIC Educational Resources Information Center

Ciarocco, Natalie J.; Dinella, Lisa M.; Hatchard, Christine J.; Valosin, Jayde

2016-01-01

The current study empirically tested the effectiveness of a modular approach to integrating professional development across an undergraduate psychology curriculum. Researchers conducted a two-group, between-subjects experiment on 269 undergraduate psychology students assessing perceptions of professional preparedness and learning. Analysis…

Developing a reliable signal wire attachment method for rail.

DOT National Transportation Integrated Search

2014-11-01

The goal of this project was to develop a better attachment method for rail signal wires to improve the reliability of signaling : systems. EWI conducted basic research into the failure mode of current attachment methods and developed and tested a ne...

Microoptomechanical sensor for intracranial pressure monitoring

NASA Astrophysics Data System (ADS)

Andreeva, A. V.; Luchinin, V. V.; Lutetskiy, N. A.; Sergushichev, A. N.

2014-12-01

The main idea of this research is the development of microoptomechanical sensor for intracranial pressure monitoring. Currently, the authors studied the scientific and technical knowledge in this field, as well as develop and test a prototype of microoptomechanical sensor for intracranial pressure (ICP) monitoring.

Pervious concrete research facility : winter performance and enhancement of pollutants removal.

DOT National Transportation Integrated Search

2013-12-01

The purpose of the current study was to design and test a porous medium that can potentially be applied in : pervious pavement systems. The principle goals were to identify a material capable of enhancing the PAH : sorption capacity, thereby mitigati...