Optimizing regional collaborative efforts to achieve long-term discipline-specific objectives

USDA-ARS?s Scientific Manuscript database

Current funding programs focused on multi-disciplinary, multi-agency approaches to regional issues can provide opportunities to address discipline-specific advancements in scientific knowledge. Projects funded through the Agricultural Research Service, Joint Fire Science Program, and the Natural Re...

Specificity of high-rise construction and real estate markets in the regional economy: an analysis of Russian practice (example of St. Petersburg)

NASA Astrophysics Data System (ADS)

Vilken, Viktoriya; Kalinina, Olga; Dubgorn, Alissa

2018-03-01

In paper features of the regional markets of construction the commercial and residential real estate on the example of St. Petersburg are defined. The current situation is analysed, the specific features of branch are revealed. The major factors influencing investors making decisions on construction of various types of objects are defined. The main methods of advance of real estate objects are considered.

Aspect-Oriented Programming

NASA Technical Reports Server (NTRS)

Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

2001-01-01

Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and Eisenecker s book includes a good survey of many of these technologies).

Structured Course Objects in a Digital Library

NASA Technical Reports Server (NTRS)

Maly, K.; Zubair, M.; Liu, X.; Nelson, M.; Zeil, S.

1999-01-01

We are developing an Undergraduate Digital Library Framework (UDLF) that will support creation/archiving of courses and reuse of existing course material to evolve courses. UDLF supports the publication of course materials for later instantiation for a specific offering and allows the addition of time-dependent and student-specific information and structures. Instructors and, depending on permissions, students can access the general course materials or the materials for a specific offering. We are building a reference implementation based on NCSTRL+, a digital library derived from NCSTRL. Digital objects in NCSTRL+ are called buckets, self-contained entities that carry their own methods for access and display. Current bucket implementations have a two level structure of packages and elements. This is not a rich enough structure for course objects in UDLF. Typically, courses can only be modeled as a multilevel hierarchy and among different courses, both the syntax and semantics of terms may vary. Therefore, we need a mechanism to define, within a particular library, course models, their constituent objects, and the associated semantics in a flexible, extensible way. In this paper, we describe our approach to define and implement these multilayered course objects. We use XML technology to emulate complex data structures within the NCSTRL+ buckets. We have developed authoring and browsing tools to manipulate these course objects. In our current implementation a user downloading an XML based course bucket also downloads the XML-aware tools: an applet that enables the user to edit or browse the bucket. We claim that XML provides an effective means to represent multi-level structure of a course bucket.

A National Survey of Mental Health Screening and Assessment Practices in Juvenile Correctional Facilities

ERIC Educational Resources Information Center

Swank, Jacqueline M.; Gagnon, Joseph C.

2017-01-01

Background: Mental health screening and assessment is crucial within juvenile correctional facilities (JC). However, limited information is available about the current screening and assessment procedures specifically within JC. Objective: The purpose of the current study was to obtain information about the mental health screening and assessment…

High-frequency CAD-based scattering model: SERMAT

NASA Astrophysics Data System (ADS)

Goupil, D.; Boutillier, M.

1991-09-01

Specifications for an industrial radar cross section (RCS) calculation code are given: it must be able to exchange data with many computer aided design (CAD) systems, it must be fast, and it must have powerful graphic tools. Classical physical optics (PO) and equivalent currents (EC) techniques have proven their efficiency on simple objects for a long time. Difficult geometric problems occur when objects with very complex shapes have to be computed. Only a specific geometric code can solve these problems. We have established that, once these problems have been solved: (1) PO and EC give good results on complex objects of large size compared to wavelength; and (2) the implementation of these objects in a software package (SERMAT) allows fast and sufficiently precise domain RCS calculations to meet industry requirements in the domain of stealth.

Sleep Disturbances in Child and Adolescent Mental Health Disorders: A Review of the Variability of Objective Sleep Markers.

PubMed

Baddam, Suman K R; Canapari, Craig A; van Noordt, Stefon J R; Crowley, Michael J

2018-06-04

Sleep disturbances are often observed in child and adolescent mental health disorders. Although previous research has identified consistent subjective reports of sleep disturbances, specific objective sleep markers have not yet been identified. We evaluated the current research on subjective and objective sleep markers in relation to attention deficit hyperactivity disorders, autism spectrum disorders, anxiety and depressive disorders. Subjective sleep markers are more consistent than objective markers of actigraphy, polysomnography, and circadian measures. We discuss the causes of variability in objective sleep findings and suggest future directions for research.

Face-specific and domain-general visual processing deficits in children with developmental prosopagnosia.

PubMed

Dalrymple, Kirsten A; Elison, Jed T; Duchaine, Brad

2017-02-01

Evidence suggests that face and object recognition depend on distinct neural circuitry within the visual system. Work with adults with developmental prosopagnosia (DP) demonstrates that some individuals have preserved object recognition despite severe face recognition deficits. This face selectivity in adults with DP indicates that face- and object-processing systems can develop independently, but it is unclear at what point in development these mechanisms are separable. Determining when individuals with DP first show dissociations between faces and objects is one means to address this question. In the current study, we investigated face and object processing in six children with DP (5-12-years-old). Each child was assessed with one face perception test, two different face memory tests, and two object memory tests that were matched to the face memory tests in format and difficulty. Scores from the DP children on the matched face and object tasks were compared to within-subject data from age-matched controls. Four of the six DP children, including the 5-year-old, showed evidence of face-specific deficits, while one child appeared to have more general visual-processing deficits. The remaining child had inconsistent results. The presence of face-specific deficits in children with DP suggests that face and object perception depend on dissociable processes in childhood.

A survey on sleep assessment methods

PubMed Central

Silva, Josep; Cauli, Omar

2018-01-01

Purpose A literature review is presented that aims to summarize and compare current methods to evaluate sleep. Methods Current sleep assessment methods have been classified according to different criteria; e.g., objective (polysomnography, actigraphy…) vs. subjective (sleep questionnaires, diaries…), contact vs. contactless devices, and need for medical assistance vs. self-assessment. A comparison of validation studies is carried out for each method, identifying their sensitivity and specificity reported in the literature. Finally, the state of the market has also been reviewed with respect to customers’ opinions about current sleep apps. Results A taxonomy that classifies the sleep detection methods. A description of each method that includes the tendencies of their underlying technologies analyzed in accordance with the literature. A comparison in terms of precision of existing validation studies and reports. Discussion In order of accuracy, sleep detection methods may be arranged as follows: Questionnaire < Sleep diary < Contactless devices < Contact devices < Polysomnography A literature review suggests that current subjective methods present a sensitivity between 73% and 97.7%, while their specificity ranges in the interval 50%–96%. Objective methods such as actigraphy present a sensibility higher than 90%. However, their specificity is low compared to their sensitivity, being one of the limitations of such technology. Moreover, there are other factors, such as the patient’s perception of her or his sleep, that can be provided only by subjective methods. Therefore, sleep detection methods should be combined to produce a synergy between objective and subjective methods. The review of the market indicates the most valued sleep apps, but it also identifies problems and gaps, e.g., many hardware devices have not been validated and (especially software apps) should be studied before their clinical use. PMID:29844990

Electric fish as natural models for technical sensor systems

NASA Astrophysics Data System (ADS)

von der Emde, Gerhard; Bousack, Herbert; Huck, Christina; Mayekar, Kavita; Pabst, Michael; Zhang, Yi

2009-05-01

Instead of vision, many animals use alternative senses for object detection. Weakly electric fish employ "active electrolocation", during which they discharge an electric organ emitting electrical current pulses (electric organ discharges, EOD). Local EODs are sensed by electroreceptors in the fish's skin, which respond to changes of the signal caused by nearby objects. Fish can gain information about attributes of an object, such as size, shape, distance, and complex impedance. When close to the fish, each object projects an 'electric image' onto the fish's skin. In order to get information about an object, the fish has to analyze the object's electric image by sampling its voltage distribution with the electroreceptors. We now know a great deal about the mechanisms the fish use to gain information about objects in their environment. Inspired by the remarkable capabilities of weakly electric fish in detecting and recognizing objects with their electric sense, we are designing technical sensor systems that can solve similar sensing problems. We applied the principles of active electrolocation to devices that produce electrical current pulses in water and simultaneously sense local current densities. Depending on the specific task, sensors can be designed which detect an object, localize it in space, determine its distance, and measure certain object properties such as material properties, thickness, or material faults. We present first experiments and FEM simulations on the optimal sensor arrangement regarding the sensor requirements e. g. localization of objects or distance measurements. Different methods of the sensor read-out and signal processing are compared.

Access management classification and spacing standards

DOT National Transportation Integrated Search

1996-08-23

The specific objectives of this background paper are:(1)Provide an overview of : the relationship between the functional integrity of the highway system and the : access management classification system, (2)Review and evaluate the current : Oregon De...

They call it like they see it: spontaneous naming and attention to shape.

PubMed

Samuelson, Larissa K; Smith, Linda B

2005-03-01

Two experiments explore children's spontaneous labeling of novel objects as a method to study early lexical access. The experiments also provide new evidence on children's attention to object shape when labeling objects. In Experiment 1, the spontaneous productions of 21 23- to 28-month-olds (mean 26;28) shown a set of novel, unnamed objects were analyzed both in terms of the specific words said and, via adult judgments, their likely perceptual basis. We found that children's spontaneous names were cued by the perceptual feature of shape. Experiment 2 examines the relation between spontaneous productions, name generalizations in a structured task, and vocabulary development in a group of children between 17 and 24 months of age (mean 21;6). Results indicate that object shape plays an important role in both spontaneous productions and novel noun generalization, but contrary to current hypotheses, children may name objects by shape from the earliest points of productive vocabulary development and this tendency may not be lexically specific.

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME IV - SITE SPECIFIC STUDIES FOR MO, MS, NC, NH, NJ, NY, OH

EPA Science Inventory

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME V - SITE SPECIFIC STUDIES FOR PA, SC, TN, VA, WI, WV

EPA Science Inventory

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME II - SITE SPECIFIC STUDIES FOR AL, DE. FL, GA, IL

EPA Science Inventory

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

RETROFIT COSTS FOR SO2 AND NOX CONTROL OPTIONS AT 200 COAL-FIRED PLANTS, VOLUME III - SITE SPECIFIC STUDIES FOR IN, KY, MA, MD, MI, MN

EPA Science Inventory

The report gives results of a study, the objective of which was to significantly improve engineering cost estimates currently being used to evaluate the economic effects of applying SO2 and NOx controls at 200 large SO2-emitting coal-fired utility plants. To accomplish the object...

A segmental analysis of current and future scanning and optimizing technology in the hardwood sawmill industry

Treesearch

S.A. Bowe; R.L. Smith; D. Earl Kline; Philip A. Araman

2002-01-01

A nationwide survey of advanced scanning and optimizing technology in the hardwood sawmill industry was conducted in the fall of 1999. Three specific hardwood sawmill technologies were examined that included current edger-optimizer systems, future edger-optimizer systems, and future automated grading systems. The objectives of the research were to determine differences...

Avian Diagnostic and Therapeutic Antibodies to Viral Emerging Pathogens

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Bradley

2011-03-31

During the current period the following key objectives were achieved: demonstration of high titer antibody production by geese following immunization with inactived H1N1 virus; completion of the epitope mapping of West Nile Virus-specific goose antibodies and initiation of epitope mapping of H1N1 flu-specific goose antibodies; advancement in scalable purification of goose antibodies.

Exemplar Variability Facilitates Retention of Word Learning by Children with Specific Language Impairment

ERIC Educational Resources Information Center

Aguilar, Jessica M.; Plante, Elena; Sandoval, Michelle

2018-01-01

Purpose: Variability in the input plays an important role in language learning. The current study examined the role of object variability for new word learning by preschoolers with specific language impairment (SLI). Method: Eighteen 4- and 5-year-old children with SLI were taught 8 new words in 3 short activities over the course of 3 sessions.…

Beyond Faces and Expertise

PubMed Central

Zhao, Mintao; Bülthoff, Heinrich H.; Bülthoff, Isabelle

2016-01-01

Holistic processing—the tendency to perceive objects as indecomposable wholes—has long been viewed as a process specific to faces or objects of expertise. Although current theories differ in what causes holistic processing, they share a fundamental constraint for its generalization: Nonface objects cannot elicit facelike holistic processing in the absence of expertise. Contrary to this prevailing view, here we show that line patterns with salient Gestalt information (i.e., connectedness, closure, and continuity between parts) can be processed as holistically as faces without any training. Moreover, weakening the saliency of Gestalt information in these patterns reduced holistic processing of them, which indicates that Gestalt information plays a crucial role in holistic processing. Therefore, holistic processing can be achieved not only via a top-down route based on expertise, but also via a bottom-up route relying merely on object-based information. The finding that facelike holistic processing can extend beyond the domains of faces and objects of expertise poses a challenge to current dominant theories. PMID:26674129

Choosing rural road investments to help reduce poverty

DOT National Transportation Integrated Search

2000-10-01

The paper examines how rural road investment projects should be selected when the specific objective is taken to be poverty reduction. After critically reviewing past and current practices, an attempt is made to develop an operational approach that i...

TRIBAL ENVIRONMENTAL PUBLIC HEALTH INDICATORS

EPA Science Inventory

Tribal-specific EPHIs are necessary because current U.S. government public health regulations and policies are based on a position that views risks and impacts as objective measures of dose-response assessments and physiological morbidity or mortality outcomes but does not ...

Collaboratives for Wildlife-Wind Turbine Interaction Research: Fostering Multistakeholder Involvement (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinclair, K.

This poster highlights the various wildlife-wind collaboratives (specific to wildlife-wind turbine interaction research) that currently exist. Examples of collaboratives are included along with contact information, objectives, benefits, and ways to advance the knowledge base.

Epidemiology and prevention of stroke: a worldwide perspective

PubMed Central

Kuklina, Elena V; Tong, Xin; George, Mary G; Bansil, Pooja

2015-01-01

This paper reviews how epidemiological studies during the last 5 years have advanced our knowledge in addressing the global stroke epidemic. The specific objectives were to review the current evidence supporting management of ten major modifiable risk factors for prevention of stroke: hypertension, current smoking, diabetes, obesity, poor diet, physical inactivity, atrial fibrillation, excessive alcohol consumption, abnormal lipid profile and psychosocial stress/depression. PMID:22288675

Review and Evaluation of Current Training Programs Found in Various Mining Environments. Final Report. Volume II, Analysis and Recommendations.

ERIC Educational Resources Information Center

Adkins, John; And Others

A project was designed to produce a broad description of current mining training programs and to evaluate their effectiveness with respect to reducing mine injuries. Aggregate training and injury data were used to evaluate the overall training effort at 300 mines as well as specific efforts in 12 categories of training course objectives. From such…

Beyond common features: The role of roles in determining similarity1

PubMed Central

Jones, Matt; Love, Bradley C.

2007-01-01

Historically, accounts of object representation and perceived similarity have focused on intrinsic features. Although more recent accounts have explored how objects, scenes, and situations containing common relational structures come to be perceived as similar, less is known about how the perceived similarity of parts or objects embedded within these relational systems is affected. The current studies test the hypothesis that objects situated in common relational systems come to be perceived as more similar. Similarity increases most for objects playing the same role within a relation (e.g., predator), but also increases for objects playing different roles within the same relation (e.g., the predator or prey role in the hunts relation) regardless of whether the objects participate in the same instance of the relation. This pattern of results can be captured by extending existing models that extract meaning from text corpora so that they are sensitive to the verb-specific thematic roles that objects fill. Alternative explanations based on analogical and inferential processes are also considered, as well as the implications of the current findings to research in language processing, personality and person perception, decision making, and category learning. PMID:17094958

Space shuttle hypergolic bipropellant RCS engine design study, Bell model 8701

NASA Technical Reports Server (NTRS)

1974-01-01

A research program was conducted to define the level of the current technology base for reaction control system rocket engines suitable for space shuttle applications. The project consisted of engine analyses, design, fabrication, and tests. The specific objectives are: (1) extrapolating current engine design experience to design of an RCS engine with required safety, reliability, performance, and operational capability, (2) demonstration of multiple reuse capability, and (3) identification of current design and technology deficiencies and critical areas for future effort.

Beyond Faces and Expertise: Facelike Holistic Processing of Nonface Objects in the Absence of Expertise.

PubMed

Zhao, Mintao; Bülthoff, Heinrich H; Bülthoff, Isabelle

2016-02-01

Holistic processing-the tendency to perceive objects as indecomposable wholes-has long been viewed as a process specific to faces or objects of expertise. Although current theories differ in what causes holistic processing, they share a fundamental constraint for its generalization: Nonface objects cannot elicit facelike holistic processing in the absence of expertise. Contrary to this prevailing view, here we show that line patterns with salient Gestalt information (i.e., connectedness, closure, and continuity between parts) can be processed as holistically as faces without any training. Moreover, weakening the saliency of Gestalt information in these patterns reduced holistic processing of them, which indicates that Gestalt information plays a crucial role in holistic processing. Therefore, holistic processing can be achieved not only via a top-down route based on expertise, but also via a bottom-up route relying merely on object-based information. The finding that facelike holistic processing can extend beyond the domains of faces and objects of expertise poses a challenge to current dominant theories. © The Author(s) 2015.

Geothermal energy employment and requirements 1977-1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-12-01

An assessment of the manpower needs of the geothermal industry is presented. The specific objectives were to: derive a base line estimate of the manpower involved in geothermal activities, determine if there is any current or impending likelihood of skill shortages, forecast future employment in the geothermal industry, conduct a technology assessment to ascertain the possibilities of some sudden breakthrough, and suggest alternatives commensurate with the findings. The methodology for fulfilling the objectives is described. Detailed results of these pursuits (objectives) are presented. Alternatives that are suggested, based upon the findings of the study, are summarized.

Climate change/variability science and adaptive strategies for state and regional transportation decision making.

DOT National Transportation Integrated Search

2010-04-01

The objective of this study was to generate a baseline understanding of current policy responses to climate : change/variability at the state and regional transportation-planning and -decision levels. Specifically, : researchers were interested in th...

COPPER CORROSION RESEARCH UPDATE

EPA Science Inventory

Copper release and corrosion related issues continue to be important to many water systems. The objective of this presentation is to discuss the current state of copper research at the USEPA. Specifically, the role of aging on copper release, use of phosphates for copper corrosio...

Thermal analyses of power subsystem components

NASA Technical Reports Server (NTRS)

Morehouse, Jeffrey H.

1990-01-01

The hiatus in the Space Shuttle (Orbiter) program provided time for an in-depth examination of all the subsystems and their past performance. Specifically, problems with reliability and/or operating limits were and continue to be of major engineering concern. The Orbiter Auxiliary Power Unit (APU) currently operates with electric resistance line heaters which are controlled with thermostats. A design option simplification of this heater subsystem is being considered which would use self-regulating heaters. A determination of the properties and thermal operating characteristics of these self-regulating heaters was needed. The Orbiter fuel cells are cooled with a freon loop. During a loss of external heat exchanger coolant flow, the single pump circulating the freon is to be left running. It was unknown what temperature and flow rate transient conditions of the freon would provide the required fuel cell cooling and for how long. The overall objective was the development of the thermal characterization and subsequent analysis of both the proposed self-regulating APU heater and the fuel cell coolant loop subsystem. The specific objective of the APU subsystem effort was to determine the feasibility of replacing the current heater and thermostat arrangement with a self-regulating heater. The specific objective of the fuel cell coolant subsystem work was to determine the tranient coolant temperature and associated flow rates during a loss-of-external heat exchanger flow.

Multiple-foil microabrasion package (A0023)

NASA Technical Reports Server (NTRS)

Mcdonnell, J. A. M.; Ashworth, D. G.; Carey, W. C.; Flavill, R. P.; Jennison, R. C.

1984-01-01

The specific scientific objectives of this experiment are to measure the spatial distribution, size, velocity, radiance, and composition of microparticles in near-Earth space. The technological objectives are to measure erosion rates resulting from microparticle impacts and to evaluate thin-foil meteor 'bumpers'. The combinations of sensitivity and reliability in this experiment will provide up to 1000 impacts per month for laboratory analysis and will extend current sensitivity limits by 5 orders of magnitude in mass.

Binary Detection using Multi-Hypothesis Log-Likelihood, Image Processing

DTIC Science & Technology

2014-03-27

geosynchronous orbit and other scenarios important to the USAF. 2 1.3 Research objectives The question posed in this thesis is how well, if at all, can a...is important to compare them to another modern technique. The third objective is to compare results from another image detection method, specifically...Although adaptive optics is an important technique in moving closer to diffraction limited imaging, it is not currently a practical solution for all

The Association between Tobacco Smoke and Serum Immunoglobulin E Levels in Korean Adults.

PubMed

Kim, Young Soo; Kim, Hee Yeon; Ahn, Hyo-Suk; Sohn, Tae Seo; Song, Jae Yen; Lee, Young Bok; Lee, Dong-Hee; Lee, Jae-Im; Jeong, Seong Cheol; Chae, Hiun Suk; Han, Kyungdo; Yeo, Chang Dong

2017-10-01

Objective Smoking is common in patients with allergic diseases. The aim of this study was to evaluate the cross-sectional association between the current smoking status and total and specific Immunoglobulin E (IgE) levels in Korean adults. Methods Data were obtained from the 2010 Korean National Health and Nutrition Examination Survey, a national cross-sectional study. We analyzed the data of subjects whose smoking status and serum IgE levels were of acceptable quality. Results A total of 1,963 subjects (1,118 never smokers, 340 ex-smokers, and 505 current smokers) were included. The total IgE levels and specific IgE levels to house dust mite Dermatophagoides farinae (Df), cockroach, and dog allergens in never smokers were significantly (p<0.0001) lower than in ex-smokers or current smokers. After adjusting for other variables, current smokers independently had significantly higher levels of total IgE and cockroach-specific IgE than ex-smokers or never smokers. The proportions of subjects with total IgE ≥150 kU/L and specific IgE ≥0.35 kU/L to Df-specific IgE were significantly (p value for trend <0.05) increased in ex-smokers and current smokers. The total IgE levels and IgE levels specific to Df, cockroaches, and dogs significantly (p value for trend <0.05) and proportionally increased with increasing numbers of cigarettes smoked daily. Conclusion Smoking was associated with elevated total IgE levels and IgE levels specific to Df, cockroach, and dog allergens in a cumulative, dose-dependent manner. Furthermore, current smoking status was an independent risk factor for elevated total IgE levels and IgE levels specific to cockroach allergen.

Customer satisfaction with patient care: "Where's the Beef?".

PubMed

Vukmir, Rade B

2006-01-01

This was an attempt to present an analysis of the literature examining objective information concerning the subject of customer service, as it applies to the current medical practice. Hopefully this information will be synthesized to generate a cogent approach to correlate customer service with quality. Articles were obtained by an English language search of MEDLINE from January 1976 to July 2005. This computerized search was supplemented with literature from the author's personal collection of peer reviewed articles on customer service in a medical setting. This information was presented in a qualitative fashion. There is a significant lack of objective data correlating customer service objectives, patient satisfaction, and quality of care. Patients present predominantly for the convenience of emergency department care. Specifics of satisfaction are directed to the timing, and amount of "caring." Demographic correlates including symptom presentation, practice style, location, and physician issues directly impact on satisfaction. It is most helpful to develop a productive plan for the "difficult patient" emphasizing communication and empathy. The current emergency medicine customer service dilemmas are a complex interaction of both patient and physician factors specifically targeting both efficiency and patient satisfaction. Awareness of these issues can help to maximize efficiency, minimize subsequent medicolegal risk and improve patient care.

Children’s level of word knowledge predicts their exclusion of familiar objects as referents of novel words

PubMed Central

Grassmann, Susanne; Schulze, Cornelia; Tomasello, Michael

2015-01-01

When children are learning a novel object label, they tend to exclude as possible referents familiar objects for which they already have a name. In the current study, we wanted to know if children would behave in this same way regardless of how well they knew the name of potential referent objects, specifically, whether they could only comprehend it or they could both comprehend and produce it. Sixty-six monolingual German-speaking 2-, 3-, and 4-year-old children participated in two experimental sessions. In one session the familiar objects were chosen such that their labels were in the children’s productive vocabularies, and in the other session the familiar objects were chosen such that their labels were only in the children’s receptive vocabularies. Results indicated that children at all three ages were more likely to exclude a familiar object as the potential referent of the novel word if they could comprehend and produce its name rather than comprehend its name only. Indeed, level of word knowledge as operationalized in this way was a better predictor than was age. These results are discussed in the context of current theories of word learning by exclusion. PMID:26322005

Diagnosis of Normal and Abnormal Color Vision with Cone-Specific VEPs.

PubMed

Rabin, Jeff C; Kryder, Andrew C; Lam, Dan

2016-05-01

Normal color vision depends on normal long wavelength (L), middle wavelength (M), and short wavelength sensitive (S) cones. Hereditary "red-green" color vision deficiency (CVD) is due to a shift in peak sensitivity or lack of L or M cones. Hereditary S cone CVD is rare but can be acquired as an early sign of disease. Current tests detect CVD but few diagnose type or severity, critical for linking performance to real-world demands. The anomaloscope and newer subjective tests quantify CVD but are not applicable to infants or cognitively impaired patients. Our purpose was to develop an objective test of CVD with sensitivity and specificity comparable to current tests. A calibrated visual-evoked potential (VEP) display and Food and Drug Administration-approved system was used to record L, M, and S cone-specific pattern-onset VEPs from 18 color vision normals (CVNs) and 13 hereditary CVDs. VEP amplitudes and latencies were compared between groups to establish VEP sensitivity and specificity. Cone VEPs show 100% sensitivity for diagnosis of CVD and 94% specificity for confirming CVN. L cone (protan) CVDs showed a significant increase in L cone latency (53.1 msec, P < 0.003) and decreased amplitude (10.8 uV, P < 0.0000005) but normal M and S cone VEPs ( P > 0.31). M cone (deutan) CVDs showed a significant increase in M cone latency (31.0 msec, P < 0.000004) and decreased amplitude (8.4 uV, P < 0.006) but normal L and S cone VEPs ( P > 0.29). Cone-specific VEPs offer a rapid, objective test to diagnose hereditary CVD and show potential for detecting acquired CVD in various diseases. This paper describes the efficacy of cone-specific color VEPs for quantification of normal and abnormal color vision. The rapid, objective nature of this approach makes it suitable for detecting color sensitivity loss in infants and the cognitively impaired.

Human face detection using motion and color information

NASA Astrophysics Data System (ADS)

Kim, Yang-Gyun; Bang, Man-Won; Park, Soon-Young; Choi, Kyoung-Ho; Hwang, Jeong-Hyun

2008-02-01

In this paper, we present a hardware implementation of a face detector for surveillance applications. To come up with a computationally cheap and fast algorithm with minimal memory requirement, motion and skin color information are fused successfully. More specifically, a newly appeared object is extracted first by comparing average Hue and Saturation values of background image and a current image. Then, the result of skin color filtering of the current image is combined with the result of a newly appeared object. Finally, labeling is performed to locate a true face region. The proposed system is implemented on Altera Cyclone2 using Quartus II 6.1 and ModelSim 6.1. For hardware description language (HDL), Verilog-HDL is used.

The Item-Specific Deficit Approach to evaluating verbal memory dysfunction: rationale, psychometrics, and application.

PubMed

Wright, Matthew J; Woo, Ellen; Schmitter-Edgecombe, Maureen; Hinkin, Charles H; Miller, Eric N; Gooding, Amanda L

2009-10-01

In the current study, we introduce the Item-Specific Deficit Approach (ISDA), a novel method for characterizing memory process deficits in list-learning data. To meet this objective, we applied the ISDA to California Verbal Learning Test (CVLT) data collected from a sample of 132 participants (53 healthy participants and 79 neurologically compromised participants). Overall, the ISDA indices measuring encoding, consolidation, and retrieval deficits demonstrated advantages over some traditional indices and indicated acceptable reliability and validity. Currently, the ISDA is intended for experimental use, although further research may support its utility for characterizing memory impairments in clinical assessments.

Flyash in continuous reinforced PCC pavement and lean concrete base : interim report.

DOT National Transportation Integrated Search

1986-08-01

The objectives of this test section were: 1) To test and evaluate the physical characteristics of flyash concrete in comparison to non-flyash concrete. Tests will be conducted to see if flyash strength, and if the current specifications for flyash ca...

Pentachlorophenol and cancer risk: Focusing the lens on specific chlorophenols and contaminants

EPA Science Inventory

Objective: Pentachlorophenol is a fungicide widely used as a wood preservative, classified in 1999 by the International Agency for Research on Cancer as a “possible human carcinogen”. We review currently available epidemiological research to determine the extent to which recent...

Detectability of Chelyabinsk-like impactors with Pan-STARRS

NASA Astrophysics Data System (ADS)

Micheli, Marco; Wainscoat, Richard J.; Denneau, Larry

2018-03-01

In this work we present the results of our analysis of the detectability of an object in the size range of the recent Chelyabinsk impactor under the current discovery and follow-up capabilities, using the specific observational strategy of the Pan-STARRS survey as a reference point. We first discuss the observability of real-life cases inspired by the impact trajectories of 2008 TC3, 2014 AA, the past Earth encounters with 2014 RC and 2015 TB145, the upcoming fly-by of 2012 TC4 and the Chelyabinsk event. We then expand our analysis with the investigation of synthetic impactors with realistic orbital distributions. Among the various conclusions of our analysis, we discuss how the time of first detectability of an object does not necessarily correspond to the moment when that same object can be recognized as an impactor. We also point out how objects discovered only a few days before impact can be immediately identified as impactors, partly thanks to the good astrometric quality that telescopes like Pan-STARRS currently achieve.

Animacy and real-world size shape object representations in the human medial temporal lobes.

PubMed

Blumenthal, Anna; Stojanoski, Bobby; Martin, Chris B; Cusack, Rhodri; Köhler, Stefan

2018-06-26

Identifying what an object is, and whether an object has been encountered before, is a crucial aspect of human behavior. Despite this importance, we do not yet have a complete understanding of the neural basis of these abilities. Investigations into the neural organization of human object representations have revealed category specific organization in the ventral visual stream in perceptual tasks. Interestingly, these categories fall within broader domains of organization, with reported distinctions between animate, inanimate large, and inanimate small objects. While there is some evidence for category specific effects in the medial temporal lobe (MTL), in particular in perirhinal and parahippocampal cortex, it is currently unclear whether domain level organization is also present across these structures. To this end, we used fMRI with a continuous recognition memory task. Stimuli were images of objects from several different categories, which were either animate or inanimate, or large or small within the inanimate domain. We employed representational similarity analysis (RSA) to test the hypothesis that object-evoked responses in MTL structures during recognition-memory judgments also show evidence for domain-level organization along both dimensions. Our data support this hypothesis. Specifically, object representations were shaped by either animacy, real-world size, or both, in perirhinal and parahippocampal cortex, and the hippocampus. While sensitivity to these dimensions differed across structures when probed individually, hinting at interesting links to functional differentiation, similarities in organization across MTL structures were more prominent overall. These results argue for continuity in the organization of object representations in the ventral visual stream and the MTL. © 2018 Wiley Periodicals, Inc.

The Automaticity of Affordance of Dangerous Object.

PubMed

Zhao, Liang

2016-11-03

Objects observation automatically elicits the activation of a reach-to-grasp response specifically directed to interact with the object, which is termed affordance. Murphy, van Velzen, and de Fockert (2012) found that only when an irrelevant object receives sufficient attention, it can potentiate an action. However, it remains unclear whether the dangerous object would afford an action when it receives insufficient attention. In this study, we manipulated the perceptual load in a letter identification task. Participants were required to identify a target letter with the right or left hand while ignoring a neutral or dangerous graspable object. The target letter was presented either on its own (low perceptual load), alongside five non-target letters (high load), or alongside eight non-target letters (super high load). Under the low perceptual load, for both neutral and dangerous object, responses were faster when the action afforded by the ignored object was congruent (vs. incongruent) with the current target response (t(27) = 4.44, p < .001; t(27) = 7.99, p < .001, respectively). However, during the high perceptual load, for dangerous object, responses were slower when the action afforded by the ignored object was congruent (vs. incongruent) with the current target response (t(27) = 4.97, p < .001). There was not any effect for both neutral object and dangerous object under super high perceptual load. These results suggest the affordance of dangerous object is also sensitive to the perceptual load. An irrelevant dangerous object can't potentiate an action if it receives insufficient attention.

CYBER WARFARE GOVERNANCE: EVALUATION OF CURRENT INTERNATIONAL AGREEMENTS ON THE OFFENSIVE USE OF CYBER

DTIC Science & Technology

2015-10-01

AIR COMMAND AND STAFF COLLEGE DISTANCE LEARNING AIR UNIVERSITY CYBER WARFARE GOVERNANCE: EVALUATION OF CURRENT INTERNATIONAL AGREEMENTS ON THE...order to prevent catastrophic second and third order effects. Rule 43 “prohibits means or methods of cyber warfare that indiscriminate by nature...Means and methods of cyber warfare are indiscriminate by nature if they cannot be: directed at a specific military objective, or limited in their

Terahertz: the Far-Ir Challenge

NASA Astrophysics Data System (ADS)

Dispenza, Massimiliano; Fiorello, Annamaria; Secchi, Alberto; Varasi, Mauro

This chapter is an overview on terahertz technologies and applications for sensing. The most advanced imaging and spectroscopy techniques are described, considering current opportunities and limitations in comparison to probes in the adjacent regions of the e.m. spectrum. Potential applications are highlighted, with a specific focus on security for detection of illicit substances and revealing of hidden objects. The technological status and current bottlenecks on sources and detectors are reviewed and future trends discussed.

Colour expectations during object perception are associated with early and late modulations of electrophysiological activity.

PubMed

Stojanoski, Bobby Boge; Niemeier, Matthias

2015-10-01

It is well known that visual expectation and attention modulate object perception. Yet, the mechanisms underlying these top-down influences are not completely understood. Event-related potentials (ERPs) indicate late contributions of expectations to object processing around the P2 or N2. This is true independent of whether people expect objects (vs. no objects) or specific shapes, hence when expectations pertain to complex visual features. However, object perception can also benefit from expecting colour information, which can facilitate figure/ground segregation. Studies on attention to colour show attention-sensitive modulations of the P1, but are limited to simple transient detection paradigms. The aim of the current study was to examine whether expecting simple features (colour information) during challenging object perception tasks produce early or late ERP modulations. We told participants to expect an object defined by predominantly black or white lines that were embedded in random arrays of distractor lines and then asked them to report the object's shape. Performance was better when colour expectations were met. ERPs revealed early and late phases of modulation. An early modulation at the P1/N1 transition arguably reflected earlier stages of object processing. Later modulations, at the P3, could be consistent with decisional processes. These results provide novel insights into feature-specific contributions of visual expectations to object perception.

Toward a Unified Theory of Visual Area V4

PubMed Central

Roe, Anna W.; Chelazzi, Leonardo; Connor, Charles E.; Conway, Bevil R.; Fujita, Ichiro; Gallant, Jack L.; Lu, Haidong; Vanduffel, Wim

2016-01-01

Visual area V4 is a midtier cortical area in the ventral visual pathway. It is crucial for visual object recognition and has been a focus of many studies on visual attention. However, there is no unifying view of V4’s role in visual processing. Neither is there an understanding of how its role in feature processing interfaces with its role in visual attention. This review captures our current knowledge of V4, largely derived from electrophysiological and imaging studies in the macaque monkey. Based on recent discovery of functionally specific domains in V4, we propose that the unifying function of V4 circuitry is to enable selective extraction of specific functional domain-based networks, whether it be by bottom-up specification of object features or by top-down attentionally driven selection. PMID:22500626

Advanced Psychotherapy Training: Psychotherapy Scholars' Track, and the Apprenticeship Model

ERIC Educational Resources Information Center

Feinstein, Robert E.; Yager, Joel

2013-01-01

Background/Objective: Guided by ACGME's requirements, psychiatric residency training in psychotherapy currently focuses on teaching school-specific forms of psychotherapy (i.e., cognitive-behavioral, supportive, and psychodynamic psychotherapy). On the basis of a literature review of common factors affecting psychotherapy outcomes and…

Energy Sources and Development.

ERIC Educational Resources Information Center

Crank, Ron

This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with energy sources and development. Its objective is for the student to be able to discuss energy sources and development related to the historical perspective, biological development, current aspects, and future expectations…

NASCAP user's manual

NASA Technical Reports Server (NTRS)

Mandell, M. J.; Harvey, J. M.; Katz, I.

1977-01-01

The NASCAP (NASA Charging Analyzer Program) code simulates the charging process for a complex object in either tenuous plasma or ground test environment. Detailed specifications needed to run the code are presented. The object definition section, OBJDEF, allows the test object to be easily defined in the cubic mesh. The test object is composed of conducting sections which may be wholly or partially covered with thin dielectric coatings. The potential section, POTENT, obtains the electrostatic potential in the space surrounding the object. It uses the conjugate gradient method to solve the finite element formulation of Poisson's equation. The CHARGE section of NASCAP treats charge redistribution among the surface cells of the object as well as charging through radiation bombardment. NASCAP has facilities for extensive graphical output, including several types of object display plots, potential contour plots, space charge density contour plots, current density plots, and particle trajectory plots.

Handling Ibuprofen Increases Pain Tolerance and Decreases Perceived Pain Intensity in a Cold Pressor Test

PubMed Central

Rutchick, Abraham M.; Slepian, Michael L.

2013-01-01

Pain contributes to health care costs, missed work and school, and lower quality of life. Extant research on psychological interventions for pain has focused primarily on developing skills that individuals can apply to manage their pain. Rather than examining internal factors that influence pain tolerance (e.g., pain management skills), the current work examines factors external to an individual that can increase pain tolerance. Specifically, the current study examined the nonconscious influence of exposure to meaningful objects on the perception of pain. Participants (N = 54) completed a cold pressor test, examined either ibuprofen or a control object, then completed another cold pressor test. In the second test, participants who previously examined ibuprofen reported experiencing less intense pain and tolerated immersion longer (relative to baseline) than those who examined the control object. Theoretical and applied implications of these findings are discussed. PMID:23469170

Description of research interests and current work related to automating software design

NASA Technical Reports Server (NTRS)

Kaindl, Hermann

1992-01-01

Enclosed is a list of selected and recent publications. Most of these publications concern applied research in the areas of software engineering and human-computer interaction. It is felt that domain-specific knowledge plays a major role in software development. Additionally, it is believed that improvements in the general software development process (e.g., object-oriented approaches) will have to be combined with the use of large domain-specific knowledge bases.

Impressed sources and fields in the volume-integral-equation formulation of electromagnetic scattering by a finite object: A tutorial

NASA Astrophysics Data System (ADS)

Mishchenko, Michael I.; Yurkin, Maxim A.

2018-07-01

Although free space cannot generate electromagnetic waves, the majority of existing accounts of frequency-domain electromagnetic scattering by particles and particle groups are based on the postulate of existence of an impressed incident field, usually in the form of a plane wave. In this tutorial we discuss how to account for the actual existence of impressed source currents rather than impressed incident fields. Specifically, we outline a self-consistent theoretical formalism describing electromagnetic scattering by an arbitrary finite object in the presence of arbitrarily distributed impressed currents, some of which can be far removed from the object and some can reside in its vicinity, including inside the object. To make the resulting formalism applicable to a wide range of scattering-object morphologies, we use the framework of the volume integral equation formulation of electromagnetic scattering, couple it with the notion of the transition operator, and exploit the fundamental symmetry property of this operator. Among novel results, this tutorial includes a streamlined proof of fundamental symmetry (reciprocity) relations, a simplified derivation of the Foldy equations, and an explicit analytical expression for the transition operator of a multi-component scattering object.

Detection of foreign body using fast thermoacoustic tomography with a multielement linear transducer array

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nie Liming; Xing Da; Yang Diwu

2007-04-23

Current imaging modalities face challenges in clinical applications due to limitations in resolution or contrast. Microwave-induced thermoacoustic imaging may provide a complementary modality for medical imaging, particularly for detecting foreign objects due to their different absorption of electromagnetic radiation at specific frequencies. A thermoacoustic tomography system with a multielement linear transducer array was developed and used to detect foreign objects in tissue. Radiography and thermoacoustic images of objects with different electromagnetic properties, including glass, sand, and iron, were compared. The authors' results demonstrate that thermoacoustic imaging has the potential to become a fast method for surgical localization of occult foreignmore » objects.« less

Customer satisfaction.

PubMed

Vukmir, Rade B

2006-01-01

This paper seeks to present an analysis of the literature examining objective information concerning the subject of customer service, as it applies to the current medical practice. Hopefully, this information will be synthesized to generate a cogent approach to correlate customer service with quality. Articles were obtained by an English language search of MEDLINE from January 1976 to July 2005. This computerized search was supplemented with literature from the author's personal collection of peer-reviewed articles on customer service in a medical setting. This information was presented in a qualitative fashion. There is a significant lack of objective data correlating customer service objectives, patient satisfaction and quality of care. Patients present predominantly for the convenience of emergency department care. Specifics of satisfaction are directed to the timing, and amount of "caring". Demographic correlates including symptom presentation, practice style, location and physician issues directly impact on satisfaction. It is most helpful to develop a productive plan for the "difficult patient", emphasizing communication and empathy. Profiling of the customer satisfaction experience is best accomplished by examining the specifics of satisfaction, nature of the ED patient, demographic profile, symptom presentation and physician interventions emphasizing communication--especially with the difficult patient. The current emergency medicine customer service dilemmas are a complex interaction of both patient and physician factors specifically targeting both efficiency and patient satisfaction. Awareness of these issues particular to the emergency patient can help to maximize efficiency, minimize subsequent medicolegal risk and improve patient care if a tailored management plan is formulated.

Change blindness and visual memory: visual representations get rich and act poor.

PubMed

Varakin, D Alexander; Levin, Daniel T

2006-02-01

Change blindness is often taken as evidence that visual representations are impoverished, while successful recognition of specific objects is taken as evidence that they are richly detailed. In the current experiments, participants performed cover tasks that required each object in a display to be attended. Change detection trials were unexpectedly introduced and surprise recognition tests were given for nonchanging displays. For both change detection and recognition, participants had to distinguish objects from the same basic-level category, making it likely that specific visual information had to be used for successful performance. Although recognition was above chance, incidental change detection usually remained at floor. These results help reconcile demonstrations of poor change detection with demonstrations of good memory because they suggest that the capability to store visual information in memory is not reflected by the visual system's tendency to utilize these representations for purposes of detecting unexpected changes.

Quantized phase coding and connected region labeling for absolute phase retrieval.

PubMed

Chen, Xiangcheng; Wang, Yuwei; Wang, Yajun; Ma, Mengchao; Zeng, Chunnian

2016-12-12

This paper proposes an absolute phase retrieval method for complex object measurement based on quantized phase-coding and connected region labeling. A specific code sequence is embedded into quantized phase of three coded fringes. Connected regions of different codes are labeled and assigned with 3-digit-codes combining the current period and its neighbors. Wrapped phase, more than 36 periods, can be restored with reference to the code sequence. Experimental results verify the capability of the proposed method to measure multiple isolated objects.

Auroral Current and Electrodynamics Structure (ACES) Observations of Ionospheric Feedback in the Alfven Resonator

NASA Technical Reports Server (NTRS)

Cohen, Ian J.; Lessard, Marc; Lund, Eric J.; Bounds, Scott R.; Kletzing, Craig; Kaeppler, Stephen R.; Sigsbee, Kristine M.; Streltsov, Anatoly V.; Labelle, James W.; Dombrowski, Micah P.;

Parental Involvement in Secondary Education Schools: The Views of Parents in Greece

ERIC Educational Resources Information Center

Antonopoulou, Katerina; Koutrouba, Konstantina; Babalis, Thomas

2011-01-01

The present study explores Greek parents' views on parental educational involvement and its impact on adolescent scholastic and social development. Specifically, aspects of parental involvement such as the achieved objectives of current parent-school communication, the psychological climate dominating teacher-parent interactions and parents'…

Global Interoperability of Broadband Networks (GIBN): Project Overview

NASA Technical Reports Server (NTRS)

DePaula, Ramon P.

1998-01-01

Various issues associated with the Global Interoperability of Broadband Networks (GIBN) are presented in viewgraph form. Specific topics include GIBN principles, objectives and goals, and background. GIBN/NASA status, the Transpacific High Definition Video experiment, GIBN experiment selection criteria, satellite industry involvement, and current experiments associated with GIBN are also discussed.

Current information technology needs of small to medium sized apparel manufacturers and contractors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wipple, C.; Vosti, E.

1997-11-01

This report documents recent efforts of the American Textile Partnership (AMTEX) Demand Activated Manufacturing Architecture (DAMA) Project to address needs that are characterized of small to medium sized apparel manufactures and contractors. Background on the AMTEX/DAMA project and objectives for this specific efforts are discussed.

Automatically Producing Accessible Learning Objects

ERIC Educational Resources Information Center

Di Iorio, Angelo; Feliziani, Antonio Angelo; Mirri, Silvia; Salomoni, Paola; Vitali, Fabio

2006-01-01

The "Anywhere, Anytime, Anyway" slogan is frequently associated to e-learning with the aim to emphasize the wide access offered by on-line education. Otherwise, learning materials are currently created to be used with a specific technology or configuration, leaving out from the virtual classroom students who have limited access capabilities and,…

Supporting Content Learning for English Learners

ERIC Educational Resources Information Center

Bauer, Eurydice B.; Manyak, Patrick C.; Cook, Crystal

2010-01-01

In this column, the three authors address the teaching of ELs within the content areas. Specifically, they highlight the difference between having language and content objectives, utilizing small-group work to maximize involvement, and inclusion of beginning English speakers into the learning process. Currently there is a gap of 36 points between…

Physicians as Managers: Psychiatry Residents' Perceived Gaps in Knowledge and Skills in Administrative Psychiatry

ERIC Educational Resources Information Center

Sockalingam, Sanjeev; Stergiopoulos, Vicky; Maggi, Julie

2007-01-01

Objective: The authors determine psychiatry residents' perceived needs and educational preferences for a physician-manager curriculum. Method: The authors surveyed 102 psychiatry residents at the University of Toronto for their perceived current and desired knowledge and skills in specific administrative areas, and their educational preferences…

Correlates of AUDIT Risk Status for Male and Female College Students

ERIC Educational Resources Information Center

DeMartini, Kelly S.; Carey, Kate B.

2009-01-01

Objective: The current study identified gender-specific correlates of hazardous drinker status as defined by the AUDIT. Participants: A total of 462 college student volunteers completed the study in 2006. The sample was predominantly Caucasian (75%) and female (55%). Methods: Participants completed a survey assessing demographics, alcohol use…

Risk Perception in Smokers with Children with Asthma

ERIC Educational Resources Information Center

Wagener, Theodore L.; Gregor, Kristin L.; Busch, Andrew M.; McQuaid, Elizabeth L.; Borrelli, Belinda

2010-01-01

Objective: No studies have examined the relationship between caregiver beliefs about the risks of smoking to their own health and caregiver beliefs about the effect of their smoking on their child's health. In the current study, we investigated our proposed "risk congruence hypothesis" among caregivers who smoke. Specifically, we investigated…

Cultural Assets and Substance Use among Hispanic Adolescents

ERIC Educational Resources Information Center

Ma, Mindy; Malcolm, Lydia R.; Díaz-Albertini, Kristine; Sánchez, Juan Carlos; Simpson, Brett; Cortes, Lissette; Kibler, Jeffrey L.

2017-01-01

Research on cultural factors and substance use among Hispanic adolescents has focused primarily on acculturation, while specific core Hispanic values and attributes have received minimal attention. The objective of the current study was to examine the relationship between traditional Hispanic cultural assets and substance use among adolescents. A…

Information Resources on Microcomputers in Libraries: Public Services. A Selected ERIC Bibliography.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Information Resources, Syracuse, NY.

Twelve articles published between 1982 and 1984 and cited in "Current Index to Journals in Education" are listed in this bibliography on public service applications of microcomputers in libraries. Topics include provision of free public access to microcomputers (justification, objectives, equipment specifications, uses and software,…

Wet Scrubber System Study. Volume II. Final Report and Bibliography.

ERIC Educational Resources Information Center

Calvert, Seymour; And Others

This report is the second volume of a two-part study on wet scrubber systems. The study was undertaken to achieve the following objectives: (1) evaluate current engineering technology, (2) evaluate existing scrubber systems, (3) investigate present usage problems, (4) determine potential new applications, and (5) develop specific research…

Comparison of the Specificity of MREIT and Dynamic Contrast-Enhanced MRI in Breast Cancer

DTIC Science & Technology

2007-05-01

ghosts ’ of objects in other slices may even appear in the reconstructed slice depending on how the conductivity and resulting 3D current density is...background and results are compared to the ideal reconstruction. (Some figures in this article are in colour only in the electronic version) 1. Introduction...eliminate any contribution from the currents flowing in those wires. Wires were mounted on acrylic support beams to establish rigidity. For all cases

Welding Niobium Bearing HSLA Steels 'Myths and Magic'

NASA Astrophysics Data System (ADS)

Kirkwood, Phil

Niobium is not currently added to ferritic steels with the specific objective of improving weldability and is more likely to be present to harness its combined beneficial effects on strength and toughness. Nevertheless, as carbon levels in many classes of HSLA steel, are progressively reduced, there is an increasing awareness that, amongst the microalloying elements, niobium is uniquely placed to deliver the mechanical property combinations that modern specifications demand and simultaneously deliver a `bonus' by way of enhanced weldability.

Perceptual Learning and Attention: Reduction of Object Attention Limitations with Practice

PubMed Central

Dosher, Barbara Anne; Han, Songmei; Lu, Zhong-Lin

2012-01-01

Perceptual learning has widely been claimed to be attention driven; attention assists in choosing the relevant sensory information and attention may be necessary in many cases for learning. In this paper, we focus on the interaction of perceptual learning and attention – that perceptual learning can reduce or eliminate the limitations of attention, or, correspondingly, that perceptual learning depends on the attention condition. Object attention is a robust limit on performance. Two attributes of a single attended object may be reported without loss, while the same two attributes of different objects can exhibit a substantial dual-report deficit due to the sharing of attention between objects. The current experiments document that this fundamental dual-object report deficit can be reduced, or eliminated, through perceptual learning that is partially specific to retinal location. This suggests that alternative routes established by practice may reduce the competition between objects for processing resources. PMID:19796653

[Design of an educational tool for Primary Care patients with chronic non-specific low back pain].

PubMed

Díaz-Cerrillo, Juan Luis; Rondón-Ramos, Antonio

2015-02-01

Current scientific evidence on the management of chronic non-specific low back pain highlights the benefits of physical exercise. This goal is frequently undermined due to lack of education of the subjects on the multifactorial, benign, and non-specific nature of low back pain, which can lead to a chronic disease with genuine psychosocial risk factors. Its influence may not only interfere with individual decision to adopt more adaptive coping behaviors, but also with the endogenous mechanisms of pain neuromodulation. Thus, the educational strategies and control of these factors have become important objectives to be incorporated into the management of the disorder and research guidelines. This paper presents the theoretical models and the scientific basis on which it has based the design of an educational tool for patients with chronic non-specific low back pain treated in Primary Care physiotherapy. Structure, content and objectives are also presented. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Applying multivariate analysis as decision tool for evaluating sediment-specific remediation strategies.

PubMed

Pedersen, Kristine B; Lejon, Tore; Jensen, Pernille E; Ottosen, Lisbeth M

2016-05-01

Multivariate methodology was employed for finding optimum remediation conditions for electrodialytic remediation of harbour sediment from an Arctic location in Norway. The parts of the experimental domain in which both sediment- and technology-specific remediation objectives were met were identified. Objectives targeted were removal of the sediment-specific pollutants Cu and Pb, while minimising the effect on the sediment matrix by limiting the removal of naturally occurring metals while maintaining low energy consumption. Two different cell designs for electrochemical remediation were tested and final concentrations of Cu and Pb were below background levels in large parts of the experimental domain when operating at low current densities (<0.12 mA/cm(2)). However, energy consumption, remediation times and the effect on naturally occurring metals were different for the 2- and 3-compartment cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

Accessible Near-Earth Objects (NEOs)

NASA Technical Reports Server (NTRS)

Barbee, Brent W.

2015-01-01

Near Earth Objects (NEOs) are asteroids and comets whose orbits are in close proximity to Earth's orbit; specifically, they have perihelia less than 1.3 astronomical units. NEOs particularly near Earth asteroids (NEAs) are identified as potential destinations for future human exploration missions. In this presentation I provide an overview of the current state of knowledge regarding the astrodynamical accessibility of NEAs according to NASA's Near Earth Object Human Space Flight Accessible Targets Study (NHATS). I also investigate the extremes of NEA accessibility using case studies and illuminate the fact that a space-based survey for NEOs is essential to expanding the set of known accessible NEAs for future human exploration missions.

Training in quality and safety: the current landscape.

PubMed

Karasick, Andrew S; Nash, David B

2015-01-01

The current US health care environment requires and encourages the development and implementation of training programs focusing on quality improvement and patient safety. This article offers a new resource that details the basic characteristics of such physician-inclusive training programs. Specifically, program type, objectives, eligibility, cost, training length, and modality are aggregated and displayed to provide health care professionals with a new tool to facilitate individual education in the field of quality improvement and patient safety. © The Author(s) 2014.

Interplay Between the Object and Its Symbol: The Size-Congruency Effect

PubMed Central

Shen, Manqiong; Xie, Jiushu; Liu, Wenjuan; Lin, Wenjie; Chen, Zhuoming; Marmolejo-Ramos, Fernando; Wang, Ruiming

2016-01-01

Grounded cognition suggests that conceptual processing shares cognitive resources with perceptual processing. Hence, conceptual processing should be affected by perceptual processing, and vice versa. The current study explored the relationship between conceptual and perceptual processing of size. Within a pair of words, we manipulated the font size of each word, which was either congruent or incongruent with the actual size of the referred object. In Experiment 1a, participants compared object sizes that were referred to by word pairs. Higher accuracy was observed in the congruent condition (e.g., word pairs referring to larger objects in larger font sizes) than in the incongruent condition. This is known as the size-congruency effect. In Experiments 1b and 2, participants compared the font sizes of these word pairs. The size-congruency effect was not observed. In Experiments 3a and 3b, participants compared object and font sizes of word pairs depending on a task cue. Results showed that perceptual processing affected conceptual processing, and vice versa. This suggested that the association between conceptual and perceptual processes may be bidirectional but further modulated by semantic processing. Specifically, conceptual processing might only affect perceptual processing when semantic information is activated. The current study PMID:27512529

Youth Depression and Early Childrearing: Stress Generation and Intergenerational Transmission of Depression

ERIC Educational Resources Information Center

Hammen, Constance; Brennan, Patricia A.; Le Brocque, Robyne

2011-01-01

Objective: Broadening the concept of stress generation beyond acute life events, the current study explores predictors of the creation of stressful environments--specifically, selection into early childrearing by age 20. It was predicted that youth with early onset depressive disorders would be at higher risk for early childrearing accompanied by…

Repetition across Successive Sentences Facilitates Young Children's Word Learning

ERIC Educational Resources Information Center

Schwab, Jessica F.; Lew-Williams, Casey

2016-01-01

Young children who hear more child-directed speech (CDS) tend to have larger vocabularies later in childhood, but the specific characteristics of CDS underlying this link are currently underspecified. The present study sought to elucidate how the structure of language input boosts learning by investigating whether repetition of object labels in…

Dementia in Ontario: Prevalence and Health Services Utilization

ERIC Educational Resources Information Center

Tranmer, J. E.; Croxford, R.; Coyte, P. C.

2003-01-01

To understand the impact of ongoing reform of mental health and dementia care in Ontario, an examination of prevalence and health services utilization rates is needed. However, there exists a gap in current prevalence and health services research specific to dementia care in Ontario. The objective of this study was to address these concerns using…

Maternal Parenting Behaviors during Childhood Relate to Weight Status and Fruit and Vegetable Intake of College Students

ERIC Educational Resources Information Center

Murashima, Megumi; Hoerr, Sharon L.; Hughes, Sheryl O.; Kattelmann, Kendra K.; Phillips, Beatrice W.

2012-01-01

Objective: Examine how maternal parenting behaviors in childhood, both general and feeding specific, relate to weight status and fruit and vegetable consumption in college students. Design: Retrospective surveys on maternal behaviors and assessments on the college-aged child's current anthropometric measures and dietary intakes. Participants:…

Developing a User Oriented Design Methodology for Learning Activities Using Boundary Objects

ERIC Educational Resources Information Center

Fragou, ?lga; Kameas, Achilles

2013-01-01

International Standards in High and Open and Distance Education are used for developing Open Educational Resources (OERs). Current issues in e-learning community are the specification of learning chunks and the definition of describing designs for different units of learning (activities, units, courses) in a generic though expandable format.…

Community Perceptions of Specific Skin Features of Possible Melanoma

ERIC Educational Resources Information Center

Baade, Peter D.; Balanda, Kevin P.; Stanton, Warren R.; Lowe, John B.; Del Mar, Chris B.

2004-01-01

Background: Melanoma can be curable if detected early. One component of detecting melanoma is an awareness of the important features of the disease. It is currently not clear which features the community view as indicative of melanoma. Objective: To investigate which features of the skin members of an urban community believe may indicate skin…

Association of Various Components of Media Literacy and Adolescent Smoking

ERIC Educational Resources Information Center

Primack, Brian A.; Hobbs, Renee

2009-01-01

Objective: To determine which specific aspects of media literacy were most strongly associated with smoking outcomes. Methods: Students at a public high school responded to cross-sectional survey items measuring smoking outcomes, components of media literacy, and other variables. Results: Of the 1211 participants, 19% were current smokers (N =…

Evaluation of two techniques for quantification of hyphal biomass

Treesearch

Meagan M. Hynes; Robert J. Zasoski; Caroline S. Bledsoe

2008-01-01

Currently, oak woodlands of Northern California and their associated mycorrhizal fungi are receiving more attention. In order to address the impact mycorrhizal fungal associations have on survival of various tree species in oak woodlands, we investigated the extramatrical fungal hyphae associated with several mature oak woodland tree species. Specifically our objective...

Clinical and diagnostic developments of a gamma interferon release assay for use in bovine tuberculosis control programs

USDA-ARS?s Scientific Manuscript database

Currently the Bovigam assay is used as an official supplemental test within the bovine tuberculosis eradication program. This assay measures interferon-gamma (IFN-gamma) produced by lymphocytes in response to specific antigens. The objectives of the present study were to evaluate two Mycobacterium ...

Affective brain-computer music interfacing

NASA Astrophysics Data System (ADS)

Daly, Ian; Williams, Duncan; Kirke, Alexis; Weaver, James; Malik, Asad; Hwang, Faustina; Miranda, Eduardo; Nasuto, Slawomir J.

2016-08-01

Objective. We aim to develop and evaluate an affective brain-computer music interface (aBCMI) for modulating the affective states of its users. Approach. An aBCMI is constructed to detect a user's current affective state and attempt to modulate it in order to achieve specific objectives (for example, making the user calmer or happier) by playing music which is generated according to a specific affective target by an algorithmic music composition system and a case-based reasoning system. The system is trained and tested in a longitudinal study on a population of eight healthy participants, with each participant returning for multiple sessions. Main results. The final online aBCMI is able to detect its users current affective states with classification accuracies of up to 65% (3 class, p\\lt 0.01) and modulate its user's affective states significantly above chance level (p\\lt 0.05). Significance. Our system represents one of the first demonstrations of an online aBCMI that is able to accurately detect and respond to user's affective states. Possible applications include use in music therapy and entertainment.

Object-based Encoding in Visual Working Memory: Evidence from Memory-driven Attentional Capture.

PubMed

Gao, Zaifeng; Yu, Shixian; Zhu, Chengfeng; Shui, Rende; Weng, Xuchu; Li, Peng; Shen, Mowei

2016-03-09

Visual working memory (VWM) adopts a specific manner of object-based encoding (OBE) to extract perceptual information: Whenever one feature-dimension is selected for entry into VWM, the others are also extracted. Currently most studies revealing OBE probed an 'irrelevant-change distracting effect', where changes of irrelevant-features dramatically affected the performance of the target feature. However, the existence of irrelevant-feature change may affect participants' processing manner, leading to a false-positive result. The current study conducted a strict examination of OBE in VWM, by probing whether irrelevant-features guided the deployment of attention in visual search. The participants memorized an object's colour yet ignored shape and concurrently performed a visual-search task. They searched for a target line among distractor lines, each embedded within a different object. One object in the search display could match the shape, colour, or both dimensions of the memory item, but this object never contained the target line. Relative to a neutral baseline, where there was no match between the memory and search displays, search time was significantly prolonged in all match conditions, regardless of whether the memory item was displayed for 100 or 1000 ms. These results suggest that task-irrelevant shape was extracted into VWM, supporting OBE in VWM.

Beyond protection: Expanding "conservation opportunity" to redefine conservation planning in the 21st century.

PubMed

Liberati, Marjorie R; Rittenhouse, Chadwick D; Vokoun, Jason C

2016-12-01

The protected lands estate increased dramatically during the 20th century and forms the backbone of current fisheries and wildlife conservation in North America. However, there is increasing evidence that modern conservation goals cannot be achieved by only focusing on adding new acreage, particularly with opportunistic protection. In the 21st century, flexibility and adaptability of conservation options can be accomplished by expanding the vocabulary of conservation planning beyond protection. We suggest a conceptual framework that considers suites of objectives to translate the broad goal of "conservation" into multiple implementation-specific objectives. These objectives form the "PCRM-PI" approach: protect, connect, restore, manage, partner, and inform. We use a case study to illustrate the limitations of protection-centric planning and how expanding the definition of conservation opportunity can help planners do more on the landscape. We suggest that the PCRM-PI approach with implementation-specific objectives is an effective way to bridge planning-implementation gaps and translate broad, landscape-level conservation goals into implementable actions. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Specific features in realization of the principle of minimum energy dissipation during individual development].

PubMed

Zotin, A A

2012-01-01

Realization of the principle of minimum energy dissipation (Prigogine's theorem) during individual development has been analyzed. This analysis has suggested the following reformulation of this principle for living objects: when environmental conditions are constant, the living system evolves to a current steady state in such a way that the difference between entropy production and entropy flow (psi(u) function) is positive and constantly decreases near the steady state, approaching zero. In turn, the current steady state tends to a final steady state in such a way that the difference between the specific entropy productions in an organism and its environment tends to be minimal. In general, individual development completely agrees with the law of entropy increase (second law of thermodynamics).

Action semantics: A unifying conceptual framework for the selective use of multimodal and modality-specific object knowledge

NASA Astrophysics Data System (ADS)

van Elk, Michiel; van Schie, Hein; Bekkering, Harold

2014-06-01

Our capacity to use tools and objects is often considered one of the hallmarks of the human species. Many objects greatly extend our bodily capabilities to act in the physical world, such as when using a hammer or a saw. In addition, humans have the remarkable capability to use objects in a flexible fashion and to combine multiple objects in complex actions. We prepare coffee, cook dinner and drive our car. In this review we propose that humans have developed declarative and procedural knowledge, i.e. action semantics that enables us to use objects in a meaningful way. A state-of-the-art review of research on object use is provided, involving behavioral, developmental, neuropsychological and neuroimaging studies. We show that research in each of these domains is characterized by similar discussions regarding (1) the role of object affordances, (2) the relation between goals and means in object use and (3) the functional and neural organization of action semantics. We propose a novel conceptual framework of action semantics to address these issues and to integrate the previous findings. We argue that action semantics entails both multimodal object representations and modality-specific sub-systems, involving manipulation knowledge, functional knowledge and representations of the sensory and proprioceptive consequences of object use. Furthermore, we argue that action semantics are hierarchically organized and selectively activated and used depending on the action intention of the actor and the current task context. Our framework presents an integrative account of multiple findings and perspectives on object use that may guide future studies in this interdisciplinary domain.

Predicting the High Redshift Galaxy Population for JWST

NASA Astrophysics Data System (ADS)

Flynn, Zoey; Benson, Andrew

2017-01-01

The James Webb Space Telescope will be launched in Oct 2018 with the goal of observing galaxies in the redshift range of z = 10 - 15. As redshift increases, the age of the Universe decreases, allowing us to study objects formed only a few hundred million years after the Big Bang. This will provide a valuable opportunity to test and improve current galaxy formation theory by comparing predictions for mass, luminosity, and number density to the observed data. We have made testable predictions with the semi-analytical galaxy formation model Galacticus. The code uses Markov Chain Monte Carlo methods to determine viable sets of model parameters that match current astronomical data. The resulting constrained model was then set to match the specifications of the JWST Ultra Deep Field Imaging Survey. Predictions utilizing up to 100 viable parameter sets were calculated, allowing us to assess the uncertainty in current theoretical expectations. We predict that the planned UDF will be able to observe a significant number of objects past redshift z > 9 but nothing at redshift z > 11. In order to detect these faint objects at redshifts z = 11-15 we need to increase exposure time by at least a factor of 1.66.

MM T for linear resonant cooler. Volume 1. Final report, October 1984-September 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayan, R.; Silvestro, J.

1988-02-16

The three-fold objectives of this contract were to: (1) enhance the producibility and performance of the prototype cooler design developed in a prior contract, (b) qualify the design to the target specification in the contract (basically the HD1045/UA B2 specification amended for 2,500 hour MTTF and low audible noise), and (c) develop and demonstrate a pilot production facility for the cooler. Technical difficulties and cost growth related to objectives (a) and (b) above precluded accomplishing (c) as part of this contract's activities. Nevertheless, performance within or exceeding all major requirements has been demonstrated, and the company is currently producing themore » cooler for use on a U.S. Air Force airborne IR system.« less

Orthorectified High Resolution Multispectral Imagery for Application to Change Detection and Analysis

NASA Technical Reports Server (NTRS)

Benkelman, Cody A.

1997-01-01

The project team has outlined several technical objectives which will allow the companies to improve on their current capabilities. These include modifications to the imaging system, enabling it to operate more cost effectively and with greater ease of use, automation of the post-processing software to mosaic and orthorectify the image scenes collected, and the addition of radiometric calibration to greatly aid in the ability to perform accurate change detection. Business objectives include fine tuning of the market plan plus specification of future product requirements, expansion of sales activities (including identification of necessary additional resources required to meet stated revenue objectives), development of a product distribution plan, and implementation of a world wide sales effort.

Survival outcomes following aggressive treatment of oligometastatic breast cancer: a systematic review protocol.

PubMed

Coombe, Robyn; Lisy, Karolina; Campbell, Jared; Perry, Gajen; Prasannan, Subhita

2017-08-01

The objective of this systematic review is to assess the effectiveness of aggressive treatment of oligometastatic breast cancer (OMBC) on survival outcomes by conducting a meta-analysis of current available evidence.More specifically, the objectives are to identify the effectiveness of intensified multidisciplinary treatment with aggressive locoregional therapies on survival time, five-year survival rates and disease free survival. The population is adult women (18 years and over) with OMBC defined as single or few (five or less) metastases limited to a single organ and the comparative group is conventional palliative treatment aimed at disease control. Secondary objectives to be assessed will be adverse outcomes associated with intensified treatment regimes.

Neural dynamics underlying attentional orienting to auditory representations in short-term memory.

PubMed

Backer, Kristina C; Binns, Malcolm A; Alain, Claude

2015-01-21

Sounds are ephemeral. Thus, coherent auditory perception depends on "hearing" back in time: retrospectively attending that which was lost externally but preserved in short-term memory (STM). Current theories of auditory attention assume that sound features are integrated into a perceptual object, that multiple objects can coexist in STM, and that attention can be deployed to an object in STM. Recording electroencephalography from humans, we tested these assumptions, elucidating feature-general and feature-specific neural correlates of auditory attention to STM. Alpha/beta oscillations and frontal and posterior event-related potentials indexed feature-general top-down attentional control to one of several coexisting auditory representations in STM. Particularly, task performance during attentional orienting was correlated with alpha/low-beta desynchronization (i.e., power suppression). However, attention to one feature could occur without simultaneous processing of the second feature of the representation. Therefore, auditory attention to memory relies on both feature-specific and feature-general neural dynamics. Copyright © 2015 the authors 0270-6474/15/351307-12$15.00/0.

Field evaluation of timber preservation treatments for highway applications

Treesearch

Jake J. Bigelow; Carol A. Clausen; Stan T. Lebow; Lowell Greimann

2007-01-01

Timber material repair and replacement cost for timber bridges is a considerable expense to highway agencies in Iowa, especially to county road departments. To address these needs, the objectives of this investigation was to study the field effectiveness of various treatment alternatives used on Iowa roadway projects and to determine if the current specifications and...

The Emergence and Evolution of School Psychology Literature: A Scientometric Analysis from 1907 through 2014

ERIC Educational Resources Information Center

Liu, Shuyan; Oakland, Thomas

2016-01-01

The objective of this current study is to identify the growth and development of scholarly literature that specifically references the term "school psychology" in the Science Citation Index from 1907 through 2014. Documents from Web of Science were accessed and analyzed through the use of scientometric analyses, including HistCite and…

The ABPN Maintenance of Certification Program for Psychiatrists: Past History, Current Status, and Future Directions

ERIC Educational Resources Information Center

Faulkner, Larry R.; Tivnan, Patricia W.; Winstead, Daniel K.; Reus, Victor I.; Andrade, Naleen N.; Brooks, Beth Ann; Colenda, Christopher C.; Mrazek, David A.; Reifler, Burton V.; Schneidman, Barbara

2008-01-01

Objective: To describe the American Board of Psychiatry and Neurology (ABPN) Maintenance of Certification Program, its underlying rationale, how it will be implemented now, and what it might look like in the future. Methods: The authors describe the philosophical foundation, specific components, and the implementation timeline of the ABPN…

The Role of the National System of Research Coordinating Units in the Research-to-Practice Continuum.

ERIC Educational Resources Information Center

Huber, Jake

Intended to stimulate and foster better communication, cooperation, and understanding between the National Institute of Education (NIE) and Research Coordinating Units (RCU) personnel, this report documents the compatibility between NIE's objectives and the current activities of the RCU's. In both general and specific terms, the activities of NIE…

Empirically Derived Subtypes of Lifetime Anxiety Disorders: Developmental and Clinical Correlates in U.S. Adolescents

ERIC Educational Resources Information Center

Burstein, Marcy; Georgiades, Katholiki; Lamers, Femke; Swanson, Sonja A.; Cui, Lihong; He, Jian-Ping; Avenevoli, Shelli; Merikangas, Kathleen R.

2012-01-01

Objective: The current study examined the sex- and age-specific structure and comorbidity of lifetime anxiety disorders among U.S. adolescents. Method: The sample consisted of 2,539 adolescents (1,505 females and 1,034 males) from the National Comorbidity Survey-Adolescent Supplement who met criteria for "Diagnostic and Statistical Manual of…

Survey of Wastewater Discharge, Eielson AFB, Alaska, EHL(K) 73-24

DTIC Science & Technology

1973-12-01

the Department of Defense. ii TABLE OF CONTENTS Section Page I. SUMMARY .................................................. 1 II. INTRODUCTION ...II. INTRODUCTION A. Purpose And Objectives The USAF Environmental Health Laboratories were requested to provide assistance in improving existing water...equivalent to best practicable control technology currently available as shall be defined for each industrial waste. 3. Proposed Performance Specifications

A LTA flight research vehicle. [technology assessment, airships

NASA Technical Reports Server (NTRS)

Nebiker, F. R.

1975-01-01

An Airship Flight Research Program is proposed. Major program objectives are summarized and a Modernized Navy ZPG3W Airship recommended as the flight test vehicle. The origin of the current interest in modern airship vehicles is briefly discussed and the major benefits resulting from the flight research program described. Airship configurations and specifications are included.

Moderators and Non-Specific Predictors of Treatment Outcome for Anxiety Disorders : A Comparison of Cognitive Behavioral Therapy to Acceptance and Commitment Therapy

ERIC Educational Resources Information Center

Wolitzky-Taylor, Kate B.; Arch, Joanna J.; Rosenfield, David; Craske, Michelle G.

2012-01-01

Objective: Understanding for whom, and under what conditions, treatments exert their greatest effects is essential for developing personalized medicine. Research investigating moderators of outcome among evidence-based treatments for anxiety disorders is lacking. The current study examined several theory-driven and atheoretical putative moderators…

The Current State of Genetics Training in Psychiatric Residency: Views of 235 U.S. Educators and Trainees

ERIC Educational Resources Information Center

Hoop, Jinger G.; Savla, Gauri; Roberts, Laura Weiss; Zisook, Sidney; Dunn, Laura B.

2010-01-01

Objective: As researchers make progress in understanding genetic aspects of mental illness and its treatment, psychiatrists will increasingly need to understand and interpret genetic information specific to psychiatric disorders. Little is known about the extent to which residency programs are preparing psychiatrists for this new role. This study…

Technology Forecasting for the Purpose of Predicting Employment Growth

ERIC Educational Resources Information Center

Smith, Cormac

2016-01-01

Throughout history, there has been a great emphasis placed on the ability to predict future events. The value of such prognostication varies between situations and domains, but the objective remains the same. Is it possible to use current or past observations to forecast future events? One specific area in which such insight is sought after is the…

Building a Global Future through Research and Innovative Practices in Open and Distance Learning

ERIC Educational Resources Information Center

Mahmood, Sheikh Tariq; Mahmood, Azhar

2014-01-01

The current study aims to investigate awareness of research students about the concept of plagiarism and to suggest possible ways to avoid it; a descriptive survey study was conducted. The objectives of the study were to examine the researcher's knowledge about concept of plagiarism, knowledge about specific terminologies, types of plagiarism, and…

A multi-resolution strategy for a multi-objective deformable image registration framework that accommodates large anatomical differences

NASA Astrophysics Data System (ADS)

Alderliesten, Tanja; Bosman, Peter A. N.; Sonke, Jan-Jakob; Bel, Arjan

2014-03-01

Currently, two major challenges dominate the field of deformable image registration. The first challenge is related to the tuning of the developed methods to specific problems (i.e. how to best combine different objectives such as similarity measure and transformation effort). This is one of the reasons why, despite significant progress, clinical implementation of such techniques has proven to be difficult. The second challenge is to account for large anatomical differences (e.g. large deformations, (dis)appearing structures) that occurred between image acquisitions. In this paper, we study a framework based on multi-objective optimization to improve registration robustness and to simplify tuning for specific applications. Within this framework we specifically consider the use of an advanced model-based evolutionary algorithm for optimization and a dual-dynamic transformation model (i.e. two "non-fixed" grids: one for the source- and one for the target image) to accommodate for large anatomical differences. The framework computes and presents multiple outcomes that represent efficient trade-offs between the different objectives (a so-called Pareto front). In image processing it is common practice, for reasons of robustness and accuracy, to use a multi-resolution strategy. This is, however, only well-established for single-objective registration methods. Here we describe how such a strategy can be realized for our multi-objective approach and compare its results with a single-resolution strategy. For this study we selected the case of prone-supine breast MRI registration. Results show that the well-known advantages of a multi-resolution strategy are successfully transferred to our multi-objective approach, resulting in superior (i.e. Pareto-dominating) outcomes.

Coverage-based constraints for IMRT optimization

NASA Astrophysics Data System (ADS)

Mescher, H.; Ulrich, S.; Bangert, M.

2017-09-01

Radiation therapy treatment planning requires an incorporation of uncertainties in order to guarantee an adequate irradiation of the tumor volumes. In current clinical practice, uncertainties are accounted for implicitly with an expansion of the target volume according to generic margin recipes. Alternatively, it is possible to account for uncertainties by explicit minimization of objectives that describe worst-case treatment scenarios, the expectation value of the treatment or the coverage probability of the target volumes during treatment planning. In this note we show that approaches relying on objectives to induce a specific coverage of the clinical target volumes are inevitably sensitive to variation of the relative weighting of the objectives. To address this issue, we introduce coverage-based constraints for intensity-modulated radiation therapy (IMRT) treatment planning. Our implementation follows the concept of coverage-optimized planning that considers explicit error scenarios to calculate and optimize patient-specific probabilities q(\\hat{d}, \\hat{v}) of covering a specific target volume fraction \\hat{v} with a certain dose \\hat{d} . Using a constraint-based reformulation of coverage-based objectives we eliminate the trade-off between coverage and competing objectives during treatment planning. In-depth convergence tests including 324 treatment plan optimizations demonstrate the reliability of coverage-based constraints for varying levels of probability, dose and volume. General clinical applicability of coverage-based constraints is demonstrated for two cases. A sensitivity analysis regarding penalty variations within this planing study based on IMRT treatment planning using (1) coverage-based constraints, (2) coverage-based objectives, (3) probabilistic optimization, (4) robust optimization and (5) conventional margins illustrates the potential benefit of coverage-based constraints that do not require tedious adjustment of target volume objectives.

Space Debris and Observational Astronomy

NASA Astrophysics Data System (ADS)

Seitzer, Patrick

2018-01-01

Since the launch of Sputnik 1 in 1957, astronomers have faced an increasing number of artificial objects contaminating their images of the night sky. Currently almost 17000 objects larger than 10 cm are tracked and have current orbits in the public catalog. Active missions are only a small fraction of these objects. Most are inactive satellites, rocket bodies, and fragments of larger objects: all space debris. Several mega-constellations are planned which will increase this number by 20% or more in low Earth orbit (LEO). In terms of observational astronomy, this population of Earth orbiting objects has three implications: 1) the number of streaks and glints from spacecraft will only increase. There are some practical steps that can be taken to minimize the number of such streaks and glints in astronomical imaging data. 2) The risk to damage to orbiting astronomical telescopes will only increase, particularly those in LEO. 3) If you are working on a plan for an orbiting telescope project, then there are specific steps that must be taken to minimize space debris generation during the mission lifetime, and actions to safely dispose of the spacecraft at end of mission to prevent it from becoming space debris and a risk to other missions. These steps may involve sacrifices to mission performance and lifetime, but are essential in today's orbital environment.

The value of public health research and the division between basic vs. applied science.

PubMed

Almeida-Filho, Namoar; Goldbaum, Moisés

2003-02-01

We question the movement towards exclusion of population and social health research from the field of science. The background under analysis is contemporary Brazil, where the scientific field that hosts this kind of research is known as Collective Health. First, the problem is formalized on logical grounds, evaluating the pertinence of considering unscientific the many objects and methods of public health research. Secondly, the cases of pulmonary tuberculosis and external causes are brought in as illustrations of the kind of scientific problem faced in health research today. The logical and epistemological basis of different forms of "scientific segregation" based on biomedical reductionism is analyzed, departing from three theses: (i) the ethics of the general application of science; (ii) the inappropriateness of monopolies for objectivity in the sciences; (iii) the specificity of scientific fields. In the current panorama of health research in Brazil, a residual hegemonic position that defends a narrow and specific definition of the object of knowledge was found. The denial of validity and specificity to objects, methods and research techniques that constitute social and population research in health is linked to elements of irrationality in reductionism approaches. Nevertheless, efforts should be directed to overcome this scientific division, in order to develop a pluralist and interdisciplinary national science, committed to the health care realities of our country.

Distributed intelligent control and management (DICAM) applications and support for semi-automated development

NASA Technical Reports Server (NTRS)

Hayes-Roth, Frederick; Erman, Lee D.; Terry, Allan; Hayes-Roth, Barbara

1992-01-01

We have recently begun a 4-year effort to develop a new technology foundation and associated methodology for the rapid development of high-performance intelligent controllers. Our objective in this work is to enable system developers to create effective real-time systems for control of multiple, coordinated entities in much less time than is currently required. Our technical strategy for achieving this objective is like that in other domain-specific software efforts: analyze the domain and task underlying effective performance, construct parametric or model-based generic components and overall solutions to the task, and provide excellent means for specifying, selecting, tailoring or automatically generating the solution elements particularly appropriate for the problem at hand. In this paper, we first present our specific domain focus, briefly describe the methodology and environment we are developing to provide a more regular approach to software development, and then later describe the issues this raises for the research community and this specific workshop.

Action semantics: A unifying conceptual framework for the selective use of multimodal and modality-specific object knowledge.

PubMed

van Elk, Michiel; van Schie, Hein; Bekkering, Harold

2014-06-01

Our capacity to use tools and objects is often considered one of the hallmarks of the human species. Many objects greatly extend our bodily capabilities to act in the physical world, such as when using a hammer or a saw. In addition, humans have the remarkable capability to use objects in a flexible fashion and to combine multiple objects in complex actions. We prepare coffee, cook dinner and drive our car. In this review we propose that humans have developed declarative and procedural knowledge, i.e. action semantics that enables us to use objects in a meaningful way. A state-of-the-art review of research on object use is provided, involving behavioral, developmental, neuropsychological and neuroimaging studies. We show that research in each of these domains is characterized by similar discussions regarding (1) the role of object affordances, (2) the relation between goals and means in object use and (3) the functional and neural organization of action semantics. We propose a novel conceptual framework of action semantics to address these issues and to integrate the previous findings. We argue that action semantics entails both multimodal object representations and modality-specific sub-systems, involving manipulation knowledge, functional knowledge and representations of the sensory and proprioceptive consequences of object use. Furthermore, we argue that action semantics are hierarchically organized and selectively activated and used depending on the action intention of the actor and the current task context. Our framework presents an integrative account of multiple findings and perspectives on object use that may guide future studies in this interdisciplinary domain. Copyright © 2013 Elsevier B.V. All rights reserved.

Flexibility Now, Consistency Later: Psychological Distance and Construal Shape Evaluative Responding

PubMed Central

Ledgerwood, Alison; Trope, Yaacov; Chaiken, Shelly

2011-01-01

Researchers have long been interested in understanding the conditions under which evaluations will be more or less consistent or context-dependent. The current research explores this issue by asking when stability or flexibility in evaluative responding would be most useful. Integrating construal level theory with research suggesting that variability in the mental representation of an attitude object can produce fluctuations in evaluative responding, we propose a functional relationship between distance and evaluative flexibility. Because individuals construe psychologically proximal objects more concretely, evaluations of proximal objects will tend to incorporate unique information from the current social context, promoting context-specific responses. Conversely, because more distal objects are construed more abstractly, evaluations of distal objects will be less context-dependent. Consistent with this reasoning, the results of 4 studies suggest that when individuals mentally construe an attitude object concretely, either because it is psychologically close or because they have been led to adopt a concrete mindset, their evaluations flexibly incorporate the views of an incidental stranger. However, when individuals think about the same issue more abstractly, their evaluations are less susceptible to incidental social influence and instead reflect their previously reported ideological values. These findings suggest that there are ways of thinking that will tend to produce more or less variability in mental representation across contexts, which in turn shapes evaluative consistency. Connections to shared reality, conformity, and attitude function are discussed. PMID:20565184

On human health.

PubMed

van Spijk, Piet

2015-05-01

If it is true that health is a priority objective of medicine, then medical practice can only be successful if the meaning of the term "health" is known. Various attempts have been made over the years to define health. This paper proposes a new definition. In addition to current health concepts, it also takes into account the distinction between specifically human (great) health and health as the absence of disease and illness-i.e. small health. The feeling of leading a life that makes sense plays a key role in determining specifically human great health.

Don't judge me: Psychophysiological evidence of gender differences to social evaluative feedback.

PubMed

Vanderhasselt, Marie-Anne; De Raedt, Rudi; Nasso, Selene; Puttevils, Louise; Mueller, Sven C

2018-05-01

Human beings have a basic need for esteemed social connections, and receiving negative self-evaluative feedback induces emotional distress. The aim of the current study is to measure eye movements (a physiological marker of attention allocation) and pupillary responses (a physiological marker of cognitive and emotional processing) as online and objective indices of participants' reaction to positive/negative social evaluations from the same or opposite sex. Following the paradigm, subjective mood ratings and heart rate variability (HRV) - as an objective index of regulatory effort- were measured. Results demonstrate clear gender-specific results in all measures. Eye-movements demonstrate that male participants respond more with other-focused attention (and specifically to male participants), whereas women respond more with self-focused attention following negative social evaluative feedback. Pupillary responses show that social evaluative feedback is specifically eliciting cognitive/affective processes in male participants to regulate emotional responses when provided by the opposite gender. Finally, following the paradigm, female (as compared to male) participants were more subjectively reactive to the paradigm (i.e., self-reports), and were less able to engage contextual- and goal related regulatory control of emotional responses (reduced HRV). Although the current study focused on psychiatrically healthy young adults, results may contribute to our understanding of sex differences in internalizing mental problems, such as rumination. Copyright © 2018 Elsevier B.V. All rights reserved.

Formalizing Knowledge in Multi-Scale Agent-Based Simulations

PubMed Central

Somogyi, Endre; Sluka, James P.; Glazier, James A.

2017-01-01

Multi-scale, agent-based simulations of cellular and tissue biology are increasingly common. These simulations combine and integrate a range of components from different domains. Simulations continuously create, destroy and reorganize constituent elements causing their interactions to dynamically change. For example, the multi-cellular tissue development process coordinates molecular, cellular and tissue scale objects with biochemical, biomechanical, spatial and behavioral processes to form a dynamic network. Different domain specific languages can describe these components in isolation, but cannot describe their interactions. No current programming language is designed to represent in human readable and reusable form the domain specific knowledge contained in these components and interactions. We present a new hybrid programming language paradigm that naturally expresses the complex multi-scale objects and dynamic interactions in a unified way and allows domain knowledge to be captured, searched, formalized, extracted and reused. PMID:29338063

Formalizing Knowledge in Multi-Scale Agent-Based Simulations.

PubMed

Somogyi, Endre; Sluka, James P; Glazier, James A

2016-10-01

Multi-scale, agent-based simulations of cellular and tissue biology are increasingly common. These simulations combine and integrate a range of components from different domains. Simulations continuously create, destroy and reorganize constituent elements causing their interactions to dynamically change. For example, the multi-cellular tissue development process coordinates molecular, cellular and tissue scale objects with biochemical, biomechanical, spatial and behavioral processes to form a dynamic network. Different domain specific languages can describe these components in isolation, but cannot describe their interactions. No current programming language is designed to represent in human readable and reusable form the domain specific knowledge contained in these components and interactions. We present a new hybrid programming language paradigm that naturally expresses the complex multi-scale objects and dynamic interactions in a unified way and allows domain knowledge to be captured, searched, formalized, extracted and reused.

A study on the utilization of advanced composites in commercial aircraft wing structure: Executive summary

NASA Technical Reports Server (NTRS)

Watts, D. J.

1978-01-01

The overall wing study objectives are to study and plan the effort by commercial transport aircraft manufacturers to accomplish the transition from current conventional materials and practices to extensive use of advanced composites in wings of aircraft that will enter service in the 1985-1990 time period. Specific wing study objectives are to define the technology and data needed to support an aircraft manufacturer's commitment to utilize composites primary wing structure in future production aircraft and to develop plans for a composite wing technology program which will provide the needed technology and data.

A Collision Avoidance Strategy for a Potential Natural Satellite around the Asteroid Bennu for the OSIRIS-REx Mission

NASA Technical Reports Server (NTRS)

Mashiku, Alinda K.; Carpenter, J. Russell

2016-01-01

The cadence of proximity operations for the OSIRIS-REx mission may have an extra induced challenge given the potential of the detection of a natural satellite orbiting the asteroid Bennu. Current ground radar observations for object detection orbiting Bennu show no found objects within bounds of specific size and rotation rates. If a natural satellite is detected during approach, a different proximity operation cadence will need to be implemented as well as a collision avoidance strategy for mission success. A collision avoidance strategy will be analyzed using the Wald Sequential Probability Ratio Test.

A Collision Avoidance Strategy for a Potential Natural Satellite Around the Asteroid Bennu for the OSIRIS-REx Mission

NASA Technical Reports Server (NTRS)

Mashiku, Alinda; Carpenter, Russell

2016-01-01

The cadence of proximity operations for the OSIRIS-REx mission may have an extra induced challenge given the potential of the detection of a natural satellite orbiting the asteroid Bennu. Current ground radar observations for object detection orbiting Bennu show no found objects within bounds of specific size and rotation rates. If a natural satellite is detected during approach, a different proximity operation cadence will need to be implemented as well as a collision avoidance strategy for mission success. A collision avoidance strategy will be analyzed using the Wald Sequential Probability Ratio Test.

A methodology for selective removal of orbital debris

NASA Technical Reports Server (NTRS)

Ash, R. L.; Odonoghue, P. J.; Chambers, E. J.; Raney, J. P.

1992-01-01

Earth-orbiting objects, large enough to be tracked, were surveyed for possible systematic debris removal. Based upon the statistical collision studies of others, it was determined that objects in orbits approximately 1000 km above the Earth's surface are at greatest collisional risk. Russian C-1B boosters were identified as the most important target of opportunity for debris removal. Currently, more than 100 in tact boosters are orbiting the Earth with apogees between 950 km and 1050 km. Using data provided by Energia USA, specific information on the C-1B booster, in terms of rendezvous and capture strategies, was discussed.

Research accomplished at the Knowledge Based Systems Lab: IDEF3, version 1.0

NASA Technical Reports Server (NTRS)

Mayer, Richard J.; Menzel, Christopher P.; Mayer, Paula S. D.

1991-01-01

An overview is presented of the foundations and content of the evolving IDEF3 process flow and object state description capture method. This method is currently in beta test. Ongoing efforts in the formulation of formal semantics models for descriptions captured in the outlined form and in the actual application of this method can be expected to cause an evolution in the method language. A language is described for the representation of process and object state centered system description. IDEF3 is a scenario driven process flow modeling methodology created specifically for these types of descriptive activities.

Alcohol Use and High-Risk Sexual Behavior among Collegiate Women: A Review of Research on Alcohol Myopia Theory

ERIC Educational Resources Information Center

Griffin, Jessica A.; Umstattd, M. Renee; Usdan, Stuart L.

2010-01-01

A review of current English literature in the areas of high-risk alcohol use and sexual behavior was conducted from September 2007 to December 2008. Objective: The purpose was to specifically review studies that used alcohol myopia theory (AMT) as the theoretical perspective from which they were evaluated and analyzed. Participants: Collegiate…

The Teaching of Complementary and Alternative Medicine in U.S. Medical Schools: A Survey of Course Directors.

ERIC Educational Resources Information Center

Brokaw, James J.; Tunnicliff, Godfrey; Raess, Beat U.; Saxon, Dale W.

2002-01-01

Surveyed medical schools to gauge the current state of complementary and alternative medicine (CAM) instruction by gathering details about the specific topics being taught and the objectives behind the instruction. Found that a wide variety of topics are being taught under the umbrella of CAM; for the most part, the instruction appears to be…

Defining Elemental Imitation Mechanisms: A Comparison of Cognitive and Motor-Spatial Imitation Learning across Object- and Computer-Based Tasks

ERIC Educational Resources Information Center

Subiaul, Francys; Zimmermann, Laura; Renner, Elizabeth; Schilder, Brian; Barr, Rachel

2016-01-01

During the first 5 years of life, the versatility, breadth, and fidelity with which children imitate change dramatically. Currently, there is no model to explain what underlies such significant changes. To that end, the present study examined whether task-independent but domain-specific--elemental--imitation mechanism explains performance across…

Extension Education: Training Coordinators to Facilitate Distance Education through the Assemblies of God Bible Institute in Belize

ERIC Educational Resources Information Center

Castleberry, Terry Lane

2010-01-01

The specific objective of this project was to train coordinators to open new extension classes and effectively facilitate existing extension classes offered by the Assemblies of God Bible Institute (AGBI) in Belize. Extensive biblical and literary research and a thorough evaluation of current extension classes led to the development of a…

Dependent Youth in Juvenile Justice: Do Positive Peer Culture Programs Work for Victims of Child Maltreatment?

ERIC Educational Resources Information Center

Ryan, Joseph P.

2006-01-01

Objective: The purpose of this study is to identify and determine the individual and group-level factors associated with recidivism for children in a long-term Positive Peer Culture (PPC) program. The current study focuses specific attention on the role of child maltreatment in understanding the risk of recidivism. It is widely accepted that…

Review of spectroscopic parameters for upper atmospheric measurements

NASA Technical Reports Server (NTRS)

Smith, M. A. H. (Editor)

1985-01-01

The workshop included communication of spectroscopic data requirements for the planned upper atmosphere research satellite (UARS) mission, review of the status of currently available spectroscopic parameters, and recommendation of additional studies. The objectives were accomplished and resulted in a series of general and specific recommendations for laboratory spectroscopy research to meet the needs of UARS and other atmospheric remote sensing programs.

Development of Advanced Life Prediction Tools for Elastic-Plastic Fatigue Crack Growth

NASA Technical Reports Server (NTRS)

Gregg, Wayne; McGill, Preston; Swanson, Greg; Wells, Doug; Throckmorton, D. A. (Technical Monitor)

2001-01-01

The objective of this viewgraph presentation is to develop a systematic approach to improving the fracture control process, including analytical tools, standards, guidelines, and awareness. Analytical tools specifically for elastic-plastic fracture analysis is a regime that is currently empirical for the Space Shuttle External Tank (ET) and is handled by simulated service testing of pre-cracked panels.

Iterative reconstruction for x-ray computed tomography using prior-image induced nonlocal regularization.

PubMed

Zhang, Hua; Huang, Jing; Ma, Jianhua; Bian, Zhaoying; Feng, Qianjin; Lu, Hongbing; Liang, Zhengrong; Chen, Wufan

2014-09-01

Repeated X-ray computed tomography (CT) scans are often required in several specific applications such as perfusion imaging, image-guided biopsy needle, image-guided intervention, and radiotherapy with noticeable benefits. However, the associated cumulative radiation dose significantly increases as comparison with that used in the conventional CT scan, which has raised major concerns in patients. In this study, to realize radiation dose reduction by reducing the X-ray tube current and exposure time (mAs) in repeated CT scans, we propose a prior-image induced nonlocal (PINL) regularization for statistical iterative reconstruction via the penalized weighted least-squares (PWLS) criteria, which we refer to as "PWLS-PINL". Specifically, the PINL regularization utilizes the redundant information in the prior image and the weighted least-squares term considers a data-dependent variance estimation, aiming to improve current low-dose image quality. Subsequently, a modified iterative successive overrelaxation algorithm is adopted to optimize the associative objective function. Experimental results on both phantom and patient data show that the present PWLS-PINL method can achieve promising gains over the other existing methods in terms of the noise reduction, low-contrast object detection, and edge detail preservation.

Iterative Reconstruction for X-Ray Computed Tomography using Prior-Image Induced Nonlocal Regularization

PubMed Central

Ma, Jianhua; Bian, Zhaoying; Feng, Qianjin; Lu, Hongbing; Liang, Zhengrong; Chen, Wufan

2014-01-01

Repeated x-ray computed tomography (CT) scans are often required in several specific applications such as perfusion imaging, image-guided biopsy needle, image-guided intervention, and radiotherapy with noticeable benefits. However, the associated cumulative radiation dose significantly increases as comparison with that used in the conventional CT scan, which has raised major concerns in patients. In this study, to realize radiation dose reduction by reducing the x-ray tube current and exposure time (mAs) in repeated CT scans, we propose a prior-image induced nonlocal (PINL) regularization for statistical iterative reconstruction via the penalized weighted least-squares (PWLS) criteria, which we refer to as “PWLS-PINL”. Specifically, the PINL regularization utilizes the redundant information in the prior image and the weighted least-squares term considers a data-dependent variance estimation, aiming to improve current low-dose image quality. Subsequently, a modified iterative successive over-relaxation algorithm is adopted to optimize the associative objective function. Experimental results on both phantom and patient data show that the present PWLS-PINL method can achieve promising gains over the other existing methods in terms of the noise reduction, low-contrast object detection and edge detail preservation. PMID:24235272

Modeling Requirements for Cohort and Register IT.

PubMed

Stäubert, Sebastian; Weber, Ulrike; Michalik, Claudia; Dress, Jochen; Ngouongo, Sylvie; Stausberg, Jürgen; Winter, Alfred

2016-01-01

The project KoRegIT (funded by TMF e.V.) aimed to develop a generic catalog of requirements for research networks like cohort studies and registers (KoReg). The catalog supports such kind of research networks to build up and to manage their organizational and IT infrastructure. To make transparent the complex relationships between requirements, which are described in use cases from a given text catalog. By analyzing and modeling the requirements a better understanding and optimizations of the catalog are intended. There are two subgoals: a) to investigate one cohort study and two registers and to model the current state of their IT infrastructure; b) to analyze the current state models and to find simplifications within the generic catalog. Processing the generic catalog was performed by means of text extraction, conceptualization and concept mapping. Then methods of enterprise architecture planning (EAP) are used to model the extracted information. To work on objective a) questionnaires are developed by utilizing the model. They are used for semi-structured interviews, whose results are evaluated via qualitative content analysis. Afterwards the current state was modeled. Objective b) was done by model analysis. A given generic text catalog of requirements was transferred into a model. As result of objective a) current state models of one existing cohort study and two registers are created and analyzed. An optimized model called KoReg-reference-model is the result of objective b). It is possible to use methods of EAP to model requirements. This enables a better overview of the partly connected requirements by means of visualization. The model based approach also enables the analysis and comparison of the empirical data from the current state models. Information managers could reduce the effort of planning the IT infrastructure utilizing the KoReg-reference-model. Modeling the current state and the generation of reports from the model, which could be used as requirements specification for bids, is supported, too.

Monsters in the sky. I mostri del cielo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maffei, P.

1980-01-01

The book treats astronomical objects and phenomena which remain unexplained or unproven by current investigators. Specific objects discussed include comets, satellite clouds surrounding the earth, tektites, the planet Vulcan (within the orbit of Mercury), Planet X (beyond Pluto), the Gum Nebula, planetary nebulae, supernovae, supernova remnants, transient X-ray sources, the possible extinction of the dinosaurs by an X-ray explosion and super-supernovae. Attention is also given to the star Eta Carinae, black holes, BL Lacertae objects, active galaxies, Markarian galaxies, N and compact galaxies, Seyfert galaxies, quasars, redshift anomalies, Stephan's quintet of galaxies, and intergalactic black holes or black dwarfs whichmore » may account for the mass necessary to bind together clusters of galaxies.« less

The Bank of Standardized Stimuli (BOSS), a New Set of 480 Normative Photos of Objects to Be Used as Visual Stimuli in Cognitive Research

PubMed Central

Brodeur, Mathieu B.; Dionne-Dostie, Emmanuelle; Montreuil, Tina; Lepage, Martin

2010-01-01

There are currently stimuli with published norms available to study several psychological aspects of language and visual cognitions. Norms represent valuable information that can be used as experimental variables or systematically controlled to limit their potential influence on another experimental manipulation. The present work proposes 480 photo stimuli that have been normalized for name, category, familiarity, visual complexity, object agreement, viewpoint agreement, and manipulability. Stimuli are also available in grayscale, blurred, scrambled, and line-drawn version. This set of objects, the Bank Of Standardized Stimuli (BOSS), was created specifically to meet the needs of scientists in cognition, vision and psycholinguistics who work with photo stimuli. PMID:20532245

The Bank of Standardized Stimuli (BOSS), a new set of 480 normative photos of objects to be used as visual stimuli in cognitive research.

PubMed

Brodeur, Mathieu B; Dionne-Dostie, Emmanuelle; Montreuil, Tina; Lepage, Martin

2010-05-24

There are currently stimuli with published norms available to study several psychological aspects of language and visual cognitions. Norms represent valuable information that can be used as experimental variables or systematically controlled to limit their potential influence on another experimental manipulation. The present work proposes 480 photo stimuli that have been normalized for name, category, familiarity, visual complexity, object agreement, viewpoint agreement, and manipulability. Stimuli are also available in grayscale, blurred, scrambled, and line-drawn version. This set of objects, the Bank Of Standardized Stimuli (BOSS), was created specifically to meet the needs of scientists in cognition, vision and psycholinguistics who work with photo stimuli.

Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose

NASA Astrophysics Data System (ADS)

Datta, Abhishek; Zhou, Xiang; Su, Yuzhou; Parra, Lucas C.; Bikson, Marom

2013-06-01

Objective. During transcranial electrical stimulation, current passage across the scalp generates voltage across the scalp surface. The goal was to characterize these scalp voltages for the purpose of validating subject-specific finite element method (FEM) models of current flow. Approach. Using a recording electrode array, we mapped skin voltages resulting from low-intensity transcranial electrical stimulation. These voltage recordings were used to compare the predictions obtained from the high-resolution model based on the subject undergoing transcranial stimulation. Main results. Each of the four stimulation electrode configurations tested resulted in a distinct distribution of scalp voltages; these spatial maps were linear with applied current amplitude (0.1 to 1 mA) over low frequencies (1 to 10 Hz). The FEM model accurately predicted the distinct voltage distributions and correlated the induced scalp voltages with current flow through cortex. Significance. Our results provide the first direct model validation for these subject-specific modeling approaches. In addition, the monitoring of scalp voltages may be used to verify electrode placement to increase transcranial electrical stimulation safety and reproducibility.

[The comparative assessment of the practical value of the currently employed methods for the recognition and species specificity of the blood].

PubMed

Grezina, N Iu; Suleĭmenova, G M

2011-01-01

The objective of the present study was to evaluate sensitivity and specificity of the HemDirect method on test-plates (Seratec) for detecting human hemoglobin (HHb). These characteristics were compared with those of other widely used methods designed for the detection of blood traces, viz. thin layer chromatography, hemotest, spectrofluorimetry, and identification of blood species specificity (by countercurrent immunoelectrophoresis in agar and on the acetate-cellulose film). It was shown that the HemDirect test is highly specific and far more sensitive than other techniques used for the same purpose in the practical work. It can be recommended as the method of choice for the detection of blood microtraces.

A category-specific top-down attentional set can affect the neural responses outside the current focus of attention.

PubMed

Jiang, Yunpeng; Wu, Xia; Gao, Xiaorong

2017-10-17

A top-down set can guide attention to enhance the processing of task-relevant objects. Many studies have found that the top-down set can be tuned to a category level. However, it is unclear whether the category-specific top-down set involving a central search task can exist outside the current area of attentional focus. To directly probe the neural responses inside and outside the current focus of attention, we recorded continuous EEG to measure the contralateral ERP components for central targets and the steady-state visual evoked potential (SSVEP) oscillations associated with a flickering checkerboard placed on the visual periphery. The relationship of color categories between targets and non-targets was manipulated to investigate the effect of category-specific top-down set. Results showed that when the color categories of targets and non-targets in the central search arrays were the same, larger SSVEP oscillations were evoked by target color peripheral checkerboards relative to the non-target color ones outside the current attentional focus. However, when the color categories of targets and non-targets were different, the peripheral checkerboards in two different colors of the same category evoked similar SSVEP oscillations, indicating the effects of category-specific top-down set. These results firstly demonstrate that the category-specific top-down set can affect the neural responses of peripheral distractors. The results could support the idea of a global selection account and challenge the attentional window account in selective attention. Copyright © 2017. Published by Elsevier B.V.

Toward an integrated account of object and action selection: A computational analysis and empirical findings from reaching-to-grasp and tool-use

PubMed Central

Botvinick, Matthew M.; Buxbaum, Laurel J.; Bylsma, Lauren M.; Jax, Steven A.

2014-01-01

The act of reaching for and acting upon an object involves two forms of selection: selection of the object as a target, and selection of the action to be performed. While these two forms of selection are logically dissociable, and are evidently subserved by separable neural pathways, they must also be closely coordinated. We examine the nature of this coordination by developing and analyzing a computational model of object and action selection first proposed by Ward [Ward, R. (1999). Interactions between perception and action systems: a model for selective action. In G. W. Humphreys, J. Duncan, & A. Treisman (Eds.), Attention, Space and Action: Studies in Cognitive Neuroscience. Oxford: Oxford University Press]. An interesting tenet of this account, which we explore in detail, is that the interplay between object and action selection depends critically on top-down inputs representing the current task set or plan of action. A concrete manifestation of this, established through a series of simulations, is that the impact of distractor objects on reaching times can vary depending on the nature of the current action plan. In order to test the model's predictions in this regard, we conducted two experiments, one involving direct object manipulation, the other involving tool-use. In both experiments we observed the specific interaction between task set and distractor type predicted by the model. Our findings provide support for the computational model, and more broadly for an interactive account of object and action selection. PMID:19100758

Magnesium Object Manager Sandbox, A More Effective Sandbox Method for Windows 7

DTIC Science & Technology

2012-03-01

keys, synchronization primitives , etc.). The object body is specific to, and the same for, each object type; it contains information common to each...the Object Directory Specific Rights Synchronization Object (Event, Mutex, Semaphore , Timer) Synchronization objects allow multiple threads to... Synchronization Object Specific Rights . . . . . . . . . . . . . . . . . . . . . 19 2.5 File Object Specific Rights

Adapting current Arden Syntax knowledge for an object oriented event monitor.

PubMed

Choi, Jeeyae; Lussier, Yves A; Mendoça, Eneida A

2003-01-01

Arden Syntax for Medical Logic Module (MLM)1 was designed for writing and sharing task-specific health knowledge in 1989. Several researchers have developed frameworks to improve the sharability and adaptability of Arden Syntax MLMs, an issue known as "curly braces" problem. Karadimas et al proposed an Arden Syntax MLM-based decision support system that uses an object oriented model and the dynamic linking features of the Java platform.2 Peleg et al proposed creating a Guideline Expression Language (GEL) based on Arden Syntax's logic grammar.3 The New York Presbyterian Hospital (NYPH) has a collection of about 200 MLMs. In a process of adapting the current MLMs for an object-oriented event monitor, we identified two problems that may influence the "curly braces" one: (1) the query expressions within the curly braces of Arden Syntax used in our institution are cryptic to the physicians, institutional dependent and written ineffectively (unpublished results), and (2) the events are coded individually within a curly braces, resulting sometimes in a large number of events - up to 200.

Categorization is modulated by transcranial direct current stimulation over left prefrontal cortex.

PubMed

Lupyan, Gary; Mirman, Daniel; Hamilton, Roy; Thompson-Schill, Sharon L

2012-07-01

Humans have an unparalleled ability to represent objects as members of multiple categories. A given object, such as a pillow may be-depending on current task demands-represented as an instance of something that is soft, as something that contains feathers, as something that is found in bedrooms, or something that is larger than a toaster. This type of processing requires the individual to dynamically highlight task-relevant properties and abstract over or suppress object properties that, although salient, are not relevant to the task at hand. Neuroimaging and neuropsychological evidence suggests that this ability may depend on cognitive control processes associated with the left inferior prefrontal gyrus. Here, we show that stimulating the left inferior frontal cortex using transcranial direct current stimulation alters performance of healthy subjects on a simple categorization task. Our task required subjects to select pictures matching a description, e.g., "click on all the round things." Cathodal stimulation led to poorer performance on classification trials requiring attention to specific dimensions such as color or shape as opposed to trials that required selecting items belonging to a more thematic category such as objects that hold water. A polarity reversal (anodal stimulation) lowered the threshold for selecting items that were more weakly associated with the target category. These results illustrate the role of frontally-mediated control processes in categorization and suggest potential interactions between categorization, cognitive control, and language. Copyright © 2012 Elsevier B.V. All rights reserved.

Categorization is modulated by transcranical direct current stimulation over left prefrontal cortex

PubMed Central

Lupyan, Gary; Mirman, Daniel; Hamilton, Roy; Thompson-Schill, Sharon L.

2013-01-01

Humans have an unparalleled ability to represent objects as members of multiple categories. A given object, such as a pillow may be—depending on current task demands—represented as an instance of something that is soft, as something that contains feathers, as something that is found in bedrooms, or something that is larger than a toaster. This type of processing requires the individual to dynamically highlight task-relevant properties and abstract over or suppress object properties that, although salient, are not relevant to the task at hand. Neuroimaging and neuropsychological evidence suggests that this ability may depend on cognitive control processes associated with the left inferior prefrontal gyrus. Here, we show that stimulating the left inferior frontal cortex using transcranial direct current stimulation alters performance of healthy subjects on a simple categorization task. Our task required subjects to select pictures matching a description, e.g., “click on all the round things.“ Cathodal stimulation led to poorer performance on classification trials requiring attention to specific dimensions such as color or shape as opposed to trials that required selecting items belonging to a more thematic category such as objects that hold water. A polarity reversal (anodal stimulation) lowered the threshold for selecting items that were more weakly associated with the target category. These results illustrate the role of frontally-mediated control processes in categorization and suggest potential interactions between categorization, cognitive control, and language. PMID:22578885

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orea, Adrian; Betancourt, Minerba

aThe objective for this project was to use MINERvA data to tune the simulation models in order to obtain the precision needed for current and future neutrino experiments. In order to do this, the current models need to be validated and then improved.more » $$\\#10146$$; Validation was done by recreating figures that have been used in previous publications $$\\#61553$$; This was done by comparing data from the detector and the simulation model (GENIE) $$\\#10146$$; Additionally, a newer version of GENIE was compared to the GENIE used for the publications to validate the new version as well as to note any improvements Another objective was to add new samples into the NUISANCE framework, which was used to compare data from the detector and simulation models. $$\\#10146$$; Specifically, the added sample was the two dimensional histogram of the double differential cross section as a function of the transversal and z-direction momentum for Numu and Numubar $$\\#61553$$; Was also used for validation« less

Algorithms and architectures for robot vision

NASA Technical Reports Server (NTRS)

Schenker, Paul S.

1990-01-01

The scope of the current work is to develop practical sensing implementations for robots operating in complex, partially unstructured environments. A focus in this work is to develop object models and estimation techniques which are specific to requirements of robot locomotion, approach and avoidance, and grasp and manipulation. Such problems have to date received limited attention in either computer or human vision - in essence, asking not only how perception is in general modeled, but also what is the functional purpose of its underlying representations. As in the past, researchers are drawing on ideas from both the psychological and machine vision literature. Of particular interest is the development 3-D shape and motion estimates for complex objects when given only partial and uncertain information and when such information is incrementally accrued over time. Current studies consider the use of surface motion, contour, and texture information, with the longer range goal of developing a fused sensing strategy based on these sources and others.

Conduction of Electrical Current to and Through the Human Body: A Review

PubMed Central

Fish, Raymond M.; Geddes, Leslie A.

2009-01-01

Objective: The objective of this article is to explain ways in which electric current is conducted to and through the human body and how this influences the nature of injuries. Methods: This multidisciplinary topic is explained by first reviewing electrical and pathophysiological principles. There are discussions of how electric current is conducted through the body via air, water, earth, and man-made conductive materials. There are also discussions of skin resistance (impedance), internal body resistance, current path through the body, the let-go phenomenon, skin breakdown, electrical stimulation of skeletal muscles and nerves, cardiac dysrhythmias and arrest, and electric shock drowning. After the review of basic principles, a number of clinically relevant examples of accident mechanisms and their medical effects are discussed. Topics related to high-voltage burns include ground faults, ground potential gradient, step and touch potentials, arcs, and lightning. Results: The practicing physician will have a better understanding of electrical mechanisms of injury and their expected clinical effects. Conclusions: There are a variety of types of electrical contact, each with important characteristics. Understanding how electric current reaches and travels through the body can help the clinician understand how and why specific accidents occur and what medical and surgical problems may be expected. PMID:19907637

Simulation verification techniques study: Simulation self test hardware design and techniques report

NASA Technical Reports Server (NTRS)

1974-01-01

The final results are presented of the hardware verification task. The basic objectives of the various subtasks are reviewed along with the ground rules under which the overall task was conducted and which impacted the approach taken in deriving techniques for hardware self test. The results of the first subtask and the definition of simulation hardware are presented. The hardware definition is based primarily on a brief review of the simulator configurations anticipated for the shuttle training program. The results of the survey of current self test techniques are presented. The data sources that were considered in the search for current techniques are reviewed, and results of the survey are presented in terms of the specific types of tests that are of interest for training simulator applications. Specifically, these types of tests are readiness tests, fault isolation tests and incipient fault detection techniques. The most applicable techniques were structured into software flows that are then referenced in discussions of techniques for specific subsystems.

Mental Health Evaluations for Adolescents Prior to Bariatric Surgery: A Review of Existing Practices and a Specific Example of Assessment Procedures

PubMed Central

Sysko, Robyn; Zandberg, Laurie J.; Devlin, Michael J.; Annunziato, Rachel A.; Zitsman, Jeffrey L.; Walsh, B. Timothy

2013-01-01

Objective Best practice guidelines for adolescents considering bariatric surgery recommend a pre-operative mental health evaluation. However, only general information about these assessments appears in the literature, which makes consistency of administration challenging. This review proposes a specific empirically-derived format for pre-surgical mental health evaluations and summarizes currently available data on the psychiatric functioning of adolescents seeking bariatric surgery. Design Studies of mental health evaluations for adults preparing for bariatric surgery are reviewed, as is the limited literature relevant to adolescent evaluations. A specific and detailed example of an evaluation (clinical interview, self-report questionnaires, cognitive assessment) used for younger patients at a major metropolitan hospital center is presented, followed by data from an initial group of adolescents completing this evaluation. Subjects 200 adolescents (n=139 female; age: 14–18 y, BMI: 35.4–83.3 kg/m2) presenting for bariatric surgery. Results A notable subset of adolescents reported current Axis I conditions (31.5%) and current mental health treatment (29.5%), but reports of current illicit drug use (1.5%) and regular alcohol use (0.5%) were relatively rare. Procedures for using the completed evaluation and post-surgery monitoring of psychosocial issues are discussed. Conclusions Adolescents considering weight loss surgery should receive comprehensive pre-surgical mental health evaluations, but additional data are needed to develop specific recommendations the use of these evaluations in post-operative care. PMID:24073019

Evaluating the validity of self-reported smoking in Mexican adolescents

PubMed Central

Valladolid-López, María del Carmen; Barrientos-Gutiérrez, Tonatiuh; Reynales-Shigematsu, Luz Myriam; Thrasher, James F; Peláez-Ballestas, Ingris; Lazcano-Ponce, Eduardo; Hernández-Ávila, Mauricio

2015-01-01

Objectives We aimed to evaluate the validity of the self-reported smoking indicator used in the Global Youth Tobacco Survey (GYTS). Setting 43 middle and high-school classrooms from 26 schools were selected from Mexico City and Cuernavaca, Morelos. Participants A total of 1257 students provided both a questionnaire and a urine sample. Primary and secondary outcome Sensitivity and specificity of self-reported smoking compared to urinary cotinine. Validity indices were evaluated by subgroups of gender, social acceptability of smoking (ie, smoking parents or friends) and smoking frequency. Results Sensitivity and specificity for current smoking were 93.2% and 81.7%, respectively. Validity indices remained stable across gender. Parental smoking status moderated the validity of self-report, which had lower sensitivity in adolescents with non-smoking parents (86.7%) than in adolescents with smoking parents (96.6%). Sensitivity and specificity increased with smoking frequency. Conclusions This first validation study of self-reported current smoking used in the GYTS among Mexican adolescents suggests that self-reported smoking in the past 30 days is a valid and stable indicator of current smoking behaviour. This measure appears suitable for public health research and surveillance. PMID:26453588

Assessing and Valuing Historical Geospatial Data for Decisions

NASA Astrophysics Data System (ADS)

Sylak-Glassman, E.; Gallo, J.

2016-12-01

We will present a method for assessing the use and valuation of historical geospatial data and information products derived from Earth observations (EO). Historical data is widely used in the establishment of baseline reference cases, time-series analysis, and Earth system modeling. Historical geospatial data is used in diverse application areas, such as risk assessment in the insurance and reinsurance industry, disaster preparedness and response planning, historical demography, land-use change analysis, and paleoclimate research, among others. Establishing the current value of previously collected data, often from EO systems that are no longer operating, is difficult since the costs associated with their preservation, maintenance, and dissemination are current, while the costs associated with their original collection are sunk. Understanding their current use and value can aid in funding decisions about the data management infrastructure and workforce allocation required to maintain their availability. Using a value-tree framework to trace the application of data from EO systems, sensors, networks, and surveys, to weighted key Federal objectives, we are able to estimate relative contribution of individual EO systems, sensors, networks, and surveys to meeting those objectives. The analysis relies on a modified Delphi method to elicit relative levels of reliance on individual EO data inputs, including historical data, from subject matter experts. This results in the identification of a representative portfolio of all EO data used to meet key Federal objectives. Because historical data is collected in conjunction with all other EO data within a weighted framework, its contribution to meeting key Federal objectives can be specifically identified and evaluated in relationship to other EO data. The results of this method could be applied better understanding and projecting the long-term value of data from current and future EO systems.

An Examination of Potential Racial and Gender Bias in the Principal Version of the Interactive Computer Interview System

ERIC Educational Resources Information Center

DiPonio, Joseph M.

2010-01-01

The primary object of this study was to determine whether racial and/or gender bias were evidenced in the use of the ICIS-Principal. Specifically, will the use of the ICIS-Principal result in biased scores at a statistically significant level when rating current practicing administrators of varying gender and race. The study involved simulated…

Systems study of fuels from grains and grasses. Quarterly progress report, July--October 1976

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, W.; Allen, A.; Athey, R.

1976-11-15

The specific objectives of the project are to determine on a geographic basis the current and potential USA production capability for grain and grass crops, to perform a preliminary screening of conversion processes, and to perform preliminary technical and economic feasibility analyses. The results obtained to date on biomass production, conversion processes, and data management are reported. (JSR)

Lunar NTR vehicle design and operations study

NASA Technical Reports Server (NTRS)

Hodge, John

1993-01-01

The results of a lunar nuclear thermal rocket (NTR) vehicle design and operations study are presented in text and graphic form. The objectives of the study were to evaluate the potential applications of a specific NTR design to past and current (First Lunar Outpost) mission profiles for piloted and cargo lunar missions, and to assess the applicability of utilizing lunar vehicle design concepts for Mars missions.

Guide d'enseignement du francais au secondaire. Volet I: Comprehension ecrite. Immersion (Teaching Guide for French at the Secondary Level. Part I: Reading Comprehension. Immersion).

ERIC Educational Resources Information Center

Leduc, Denise

This guide to secondary school French reading instruction addresses a variety of general and specific instructional issues. An introductory chapter discusses program objectives, minimum program requirements, and the population to be taught. The second chapter looks at theoretical aspects of the development of reading ability: current thoughts on…

The lasting effects of process-specific versus stimulus-specific learning during infancy.

PubMed

Hadley, Hillary; Pickron, Charisse B; Scott, Lisa S

2015-09-01

The capacity to tell the difference between two faces within an infrequently experienced face group (e.g. other species, other race) declines from 6 to 9 months of age unless infants learn to match these faces with individual-level names. Similarly, the use of individual-level labels can also facilitate differentiation of a group of non-face objects (strollers). This early learning leads to increased neural specialization for previously unfamiliar face or object groups. The current investigation aimed to determine whether early conceptual learning between 6 and 9 months leads to sustained behavioral advantages and neural changes in these same children at 4-6 years of age. Results suggest that relative to a control group of children with no previous training and to children with infant category-level naming experience, children with early individual-level training exhibited faster response times to human faces. Further, individual-level training with a face group - but not an object group - led to more adult-like neural responses for human faces. These results suggest that early individual-level learning results in long-lasting process-specific effects, which benefit categories that continue to be perceived and recognized at the individual level (e.g. human faces). © 2014 John Wiley & Sons Ltd.

Aspects of image recognition in Vivid Technologies' dual-energy x-ray system for explosives detection

NASA Astrophysics Data System (ADS)

Eilbert, Richard F.; Krug, Kristoph D.

1993-04-01

The Vivid Rapid Explosives Detection Systems is a true dual energy x-ray machine employing precision x-ray data acquisition in combination with unique algorithms and massive computation capability. Data from the system's 960 detectors is digitally stored and processed by powerful supermicro-computers organized as an expandable array of parallel processors. The algorithms operate on the dual energy attenuation image data to recognize and define objects in the milieu of the baggage contents. Each object is then systematically examined for a match to a specific effective atomic number, density, and mass threshold. Material properties are determined by comparing the relative attenuations of the 75 kVp and 150 kVp beams and electronically separating the object from its local background. Other heuristic algorithms search for specific configurations and provide additional information. The machine automatically detects explosive materials and identifies bomb components in luggage with high specificity and throughput, X-ray dose is comparable to that of current airport x-ray machines. The machine is also configured to find heroin, cocaine, and US currency by selecting appropriate settings on-site. Since January 1992, production units have been operationally deployed at U.S. and European airports for improved screening of checked baggage.

The Mistreatment of Major Depressive Disorder

PubMed Central

Paris, Joel

2014-01-01

Objective: To examine the effects of classification on treatment in major depressive disorder (MDD). Method: This is a narrative review. Results: MDD is a highly heterogeneous category, leading to problems in classification and in specificity of treatment. Current models classify all depressions within a single category. However, the construct of MDD obscures important differences between severe disorders that require pharmacotherapy, and mild-to-moderate disorders that can respond to psychotherapy or remit spontaneously. Patients with mild-to-moderate MDD are being treated with routine or overly aggressive pharmacotherapy. Conclusions: The current classification fails to address the heterogeneity of depression, leading to mistreatment. PMID:24881163

A Generalized Decision Framework Using Multi-objective Optimization for Water Resources Planning

NASA Astrophysics Data System (ADS)

Basdekas, L.; Stewart, N.; Triana, E.

2013-12-01

Colorado Springs Utilities (CSU) is currently engaged in an Integrated Water Resource Plan (IWRP) to address the complex planning scenarios, across multiple time scales, currently faced by CSU. The modeling framework developed for the IWRP uses a flexible data-centered Decision Support System (DSS) with a MODSIM-based modeling system to represent the operation of the current CSU raw water system coupled with a state-of-the-art multi-objective optimization algorithm. Three basic components are required for the framework, which can be implemented for planning horizons ranging from seasonal to interdecadal. First, a water resources system model is required that is capable of reasonable system simulation to resolve performance metrics at the appropriate temporal and spatial scales of interest. The system model should be an existing simulation model, or one developed during the planning process with stakeholders, so that 'buy-in' has already been achieved. Second, a hydrologic scenario tool(s) capable of generating a range of plausible inflows for the planning period of interest is required. This may include paleo informed or climate change informed sequences. Third, a multi-objective optimization model that can be wrapped around the system simulation model is required. The new generation of multi-objective optimization models do not require parameterization which greatly reduces problem complexity. Bridging the gap between research and practice will be evident as we use a case study from CSU's planning process to demonstrate this framework with specific competing water management objectives. Careful formulation of objective functions, choice of decision variables, and system constraints will be discussed. Rather than treating results as theoretically Pareto optimal in a planning process, we use the powerful multi-objective optimization models as tools to more efficiently and effectively move out of the inferior decision space. The use of this framework will help CSU evaluate tradeoffs in a continually changing world.

Sizing Single Cantilever Beam Specimens for Characterizing Facesheet/Core Peel Debonding in Sandwich Structure

NASA Technical Reports Server (NTRS)

Ratcliffe, James G.

2010-01-01

This paper details part of an effort focused on the development of a standardized facesheet/core peel debonding test procedure. The purpose of the test is to characterize facesheet/core peel in sandwich structure, accomplished through the measurement of the critical strain energy release rate associated with the debonding process. The specific test method selected for the standardized test procedure utilizes a single cantilever beam (SCB) specimen configuration. The objective of the current work is to develop a method for establishing SCB specimen dimensions. This is achieved by imposing specific limitations on specimen dimensions, with the objectives of promoting a linear elastic specimen response, and simplifying the data reduction method required for computing the critical strain energy release rate associated with debonding. The sizing method is also designed to be suitable for incorporation into a standardized test protocol. Preliminary application of the resulting sizing method yields practical specimen dimensions.

Redefining the Practice of Peer Review Through Intelligent Automation Part 1: Creation of a Standardized Methodology and Referenceable Database.

PubMed

Reiner, Bruce I

2017-10-01

Conventional peer review practice is compromised by a number of well-documented biases, which in turn limit standard of care analysis, which is fundamental to determination of medical malpractice. In addition to these intrinsic biases, other existing deficiencies exist in current peer review including the lack of standardization, objectivity, retrospective practice, and automation. An alternative model to address these deficiencies would be one which is completely blinded to the peer reviewer, requires independent reporting from both parties, utilizes automated data mining techniques for neutral and objective report analysis, and provides data reconciliation for resolution of finding-specific report differences. If properly implemented, this peer review model could result in creation of a standardized referenceable peer review database which could further assist in customizable education, technology refinement, and implementation of real-time context and user-specific decision support.

United Kingdom Infrared Telescope's Spectrograph Observations of Human-Made Space Objects

NASA Technical Reports Server (NTRS)

Buckalew, Brent; Abercromby, Kira; Lederer, Susan; Frith, James; Cowardin, Heather

2017-01-01

Presented here are the results of the United Kingdom Infrared Telescope (UKIRT) spectral observations of human-made space objects taken from 2014 to 2015. The data collected using the UIST infrared spectrograph cover the wavelength range 0.7-2.5 micrometers. Overall, data were collected on 18 different orbiting objects at or near the geosynchronous (GEO) regime. Thirteen of the objects are spacecraft, one is a rocket body, and four are cataloged as debris pieces. The remotely collected data are compared to the laboratory-collected reflectance data on typical spacecraft materials; thereby general materials are identified but not specific types. These results highlight the usefulness of observations in the infrared by focusing on features from hydrocarbons and silicon. The spacecraft show distinct features due to the presence of solar panels. Signature variations between rocket bodies, due to the presence of various metals and paints on their surfaces, show a clear distinction from those objects with solar panels, demonstrating that one can distinguish most spacecraft from rocket bodies through infrared spectrum analysis. Finally, the debris pieces tend to show featureless, dark spectra. These results show that the laboratory data in its current state give excellent indications as to the nature of the surface materials on the objects. Further telescopic data collection and model updates to include more materials, noise, surface roughness, and material degradation are necessary to make better assessments of orbital object material types. A comparison conducted between objects observed previously with the NASA Infrared Telescope Facility (IRTF) shows similar materials and trends from the two telescopes and from the two distinct data sets. However, based on the current state of the model, infrared spectroscopic data are adequate to classify objects in GEO as spacecraft, rocket bodies, or debris.

Moving object detection using dynamic motion modelling from UAV aerial images.

PubMed

Saif, A F M Saifuddin; Prabuwono, Anton Satria; Mahayuddin, Zainal Rasyid

2014-01-01

Motion analysis based moving object detection from UAV aerial image is still an unsolved issue due to inconsideration of proper motion estimation. Existing moving object detection approaches from UAV aerial images did not deal with motion based pixel intensity measurement to detect moving object robustly. Besides current research on moving object detection from UAV aerial images mostly depends on either frame difference or segmentation approach separately. There are two main purposes for this research: firstly to develop a new motion model called DMM (dynamic motion model) and secondly to apply the proposed segmentation approach SUED (segmentation using edge based dilation) using frame difference embedded together with DMM model. The proposed DMM model provides effective search windows based on the highest pixel intensity to segment only specific area for moving object rather than searching the whole area of the frame using SUED. At each stage of the proposed scheme, experimental fusion of the DMM and SUED produces extracted moving objects faithfully. Experimental result reveals that the proposed DMM and SUED have successfully demonstrated the validity of the proposed methodology.

Distinct neural substrates for visual short-term memory of actions.

PubMed

Cai, Ying; Urgolites, Zhisen; Wood, Justin; Chen, Chuansheng; Li, Siyao; Chen, Antao; Xue, Gui

2018-06-26

Fundamental theories of human cognition have long posited that the short-term maintenance of actions is supported by one of the "core knowledge" systems of human visual cognition, yet its neural substrates are still not well understood. In particular, it is unclear whether the visual short-term memory (VSTM) of actions has distinct neural substrates or, as proposed by the spatio-object architecture of VSTM, shares them with VSTM of objects and spatial locations. In two experiments, we tested these two competing hypotheses by directly contrasting the neural substrates for VSTM of actions with those for objects and locations. Our results showed that the bilateral middle temporal cortex (MT) was specifically involved in VSTM of actions because its activation and its functional connectivity with the frontal-parietal network (FPN) were only modulated by the memory load of actions, but not by that of objects/agents or locations. Moreover, the brain regions involved in the maintenance of spatial location information (i.e., superior parietal lobule, SPL) was also recruited during the maintenance of actions, consistent with the temporal-spatial nature of actions. Meanwhile, the frontoparietal network (FPN) was commonly involved in all types of VSTM and showed flexible functional connectivity with the domain-specific regions, depending on the current working memory tasks. Together, our results provide clear evidence for a distinct neural system for maintaining actions in VSTM, which supports the core knowledge system theory and the domain-specific and domain-general architectures of VSTM. © 2018 Wiley Periodicals, Inc.

Temporal Dynamics of Activation of Thematic and Functional Knowledge During Conceptual Processing of Manipulable Artifacts

PubMed Central

Kalénine, Solène; Mirman, Daniel; Middleton, Erica L.; Buxbaum, Laurel J.

2012-01-01

The current research aimed at specifying the activation time course of different types of semantic information during object conceptual processing and the effect of context on this time course. We distinguished between thematic and functional knowledge and the specificity of functional similarity. Two experiments were conducted with healthy older adults using eye tracking in a word-to-picture matching task. The time course of gaze fixations was used to assess activation of distractor objects during the identification of manipulable artifact targets (e.g., broom). Distractors were (a) thematically related (e.g., dustpan), (b) related by a specific function (e.g., vacuum cleaner), or (c) related by a general function (e.g., sponge). Growth curve analyses were used to assess competition effects when target words were presented in isolation (Experiment 1) and embedded in contextual sentences of different generality levels (Experiment 2). In the absence of context, there was earlier and shorter lasting activation of thematically related as compared to functionally related objects. The time course difference was more pronounced for general functions than specific functions. When contexts were provided, functional similarities that were congruent with context generality level increased in salience with earlier activation of those objects. Context had little impact on thematic activation time course. These data demonstrate that processing a single manipulable artifact concept implicitly activates thematic and functional knowledge with different time courses and that context speeds activation of context-congruent functional similarity. PMID:22449134

Role of the parahippocampal cortex in memory for the configuration but not the identity of objects: converging evidence from patients with selective thermal lesions and fMRI.

PubMed

Bohbot, Véronique D; Allen, John J B; Dagher, Alain; Dumoulin, Serge O; Evans, Alan C; Petrides, Michael; Kalina, Miroslav; Stepankova, Katerina; Nadel, Lynn

2015-01-01

The parahippocampal cortex and hippocampus are brain structures known to be involved in memory. However, the unique contribution of the parahippocampal cortex remains unclear. The current study investigates memory for object identity and memory of the configuration of objects in patients with small thermo-coagulation lesions to the hippocampus or the parahippocampal cortex. Results showed that in contrast to control participants and patients with damage to the hippocampus leaving the parahippocampal cortex intact, patients with lesions that included the right parahippocampal cortex (RPH) were severely impaired on a task that required learning the spatial configuration of objects on a computer screen; these patients, however, were not impaired at learning the identity of objects. Conversely, we found that patients with lesions to the right hippocampus (RH) or left hippocampus (LH), sparing the parahippocampal cortex, performed just as well as the control participants. Furthermore, they were not impaired on the object identity task. In the functional Magnetic Resonance Imaging (fMRI) experiment, healthy young adults performed the same tasks. Consistent with the findings of the lesion study, the fMRI results showed significant activity in the RPH in the memory for the spatial configuration condition, but not memory for object identity. Furthermore, the pattern of fMRI activity measured in the baseline control conditions decreased specifically in the parahippocampal cortex as a result of the experimental task, providing evidence for task specific repetition suppression. In summary, while our previous studies demonstrated that the hippocampus is critical to the construction of a cognitive map, both the lesion and fMRI studies have shown an involvement of the RPH for learning spatial configurations of objects but not object identity, and that this takes place independent of the hippocampus.

Not planning a sustainable transport system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finnveden, Göran, E-mail: goran.finnveden@abe.kth.se; Åkerman, Jonas

2014-04-01

The overall objective of the Swedish transport policy is to ensure the economically efficient and sustainable provision of transport services for people and business throughout the country. More specifically, the transport sector shall, among other things, contribute to the achievement of environmental quality objectives in which the development of the transport system plays an important role in the achievement of the objectives. The aim of this study is to analyse if current transport planning supports this policy. This is done by analysing two recent cases: the National Infrastructure Plan 2010–2021, and the planning of Bypass Stockholm, a major road investment.more » Our results show that the plans are in conflict with several of the environmental quality objectives. Another interesting aspect of the planning processes is that the long-term climate goals are not included in the planning processes, neither as a clear goal nor as factor that will influence future transport systems. In this way, the long-term sustainability aspects are not present in the planning. We conclude that the two cases do not contribute to a sustainable transport system. Thus, several changes must be made in the processes, including putting up clear targets for emissions. Also, the methodology for the environmental assessments needs to be further developed and discussed. - Highlights: • Two cases are studied to analyse if current planning supports a sustainable transport system. • Results show that the plans are in conflict with several of the environmental quality objectives. • Long-term climate goals are not included in the planning processes. • Current practices do not contribute to a sustainable planning processes. • Methodology and process for environmental assessments must be further developed and discussed.« less

Summary of NASA Aerospace Flight Battery Systems Program activities

NASA Technical Reports Server (NTRS)

Manzo, Michelle; Odonnell, Patricia

1994-01-01

A summary of NASA Aerospace Flight Battery Systems Program Activities is presented. The NASA Aerospace Flight Battery Systems Program represents a unified NASA wide effort with the overall objective of providing NASA with the policy and posture which will increase the safety, performance, and reliability of space power systems. The specific objectives of the program are to: enhance cell/battery safety and reliability; maintain current battery technology; increase fundamental understanding of primary and secondary cells; provide a means to bring forth advanced technology for flight use; assist flight programs in minimizing battery technology related flight risks; and ensure that safe, reliable batteries are available for NASA's future missions.

Generic, Type-Safe and Object Oriented Computer Algebra Software

NASA Astrophysics Data System (ADS)

Kredel, Heinz; Jolly, Raphael

Advances in computer science, in particular object oriented programming, and software engineering have had little practical impact on computer algebra systems in the last 30 years. The software design of existing systems is still dominated by ad-hoc memory management, weakly typed algorithm libraries and proprietary domain specific interactive expression interpreters. We discuss a modular approach to computer algebra software: usage of state-of-the-art memory management and run-time systems (e.g. JVM) usage of strongly typed, generic, object oriented programming languages (e.g. Java) and usage of general purpose, dynamic interactive expression interpreters (e.g. Python) To illustrate the workability of this approach, we have implemented and studied computer algebra systems in Java and Scala. In this paper we report on the current state of this work by presenting new examples.

An fMRI Study of Episodic Memory: Retrieval of Object, Spatial, and Temporal Information

PubMed Central

Hayes, Scott M.; Ryan, Lee; Schnyer, David M.; Nadel, Lynn

2011-01-01

Sixteen participants viewed a videotaped tour of 4 houses, highlighting a series of objects and their spatial locations. Participants were tested for memory of object, spatial, and temporal order information while undergoing functional Magnetic Resonance Imaging. Preferential activation was observed in right parahippocampal gyrus during the retrieval of spatial location information. Retrieval of contextual information (spatial location and temporal order) was associated with activation in right dorsolateral prefrontal cortex. In bilateral posterior parietal regions, greater activation was associated with processing of visual scenes, regardless of the memory judgment. These findings support current theories positing roles for frontal and medial temporal regions during episodic retrieval and suggest a specific role for the hippocampal complex in the retrieval of spatial location information PMID:15506871

Hot air heat gun

NASA Astrophysics Data System (ADS)

Poston, Terry L.

1989-10-01

The invention relates generally to the art of self-contained heating devices and in particular to portable heating devices employing chemical reaction to produce heat. Currently, hand-held heat sources, capable of producing heat at a sufficiently high temperature to activate heat-shrink material, rely on either the combustion of flammable material or electrical power to provide energy for generating the required heat. An object of the present invention is to provide a portable device capable of providing sufficient heat to shrink heat-shrinkable tubing. A further object of the invention is to provide a non-flammable heat source suitable for use in the presence of explosive atmospheres. Still another object of the invention is to provide a portable hand-held device for generating heat which can be directed to a specific location on a work surface.

Modeling the weather impact on aviation in a global air traffic model

NASA Astrophysics Data System (ADS)

Himmelsbach, S.; Hauf, T.; Rokitansky, C. H.

2009-09-01

Weather has a strong impact on aviation safety and efficiency. For a better understanding of that impact, especially of thunderstorms and similar other severe hazards, we pursued a modeling approach. We used the detailed simulation software (NAVSIM) of worldwide air traffic, developed by Rokitansky [Eurocontrol, 2005] and implemented a specific weather module. NAVSIM models each aircraft with its specific performance characteristics separately along preplanned and prescribed routes. The specific weather module in its current version simulates a thunderstorm as an impenetrable 3D object, which forces an aircraft to circumvent the latter. We refer to that object in general terms as a weather object. The Cb-weather object, as a specific weather object, is a heuristic model of a real thunderstorm, with its characteristics based on actually observed satellite and precipitation radar data. It is comprised of an upper volume, mostly the anvil, and a bottom volume, the up- and downdrafts and the lower outflow area [Tafferner and Forster, 2009; Kober and Tafferner 2009; Zinner et al, 2008]. The Cb-weather object is already implemented in NAVSIM, other weather objects like icing and turbulence will follow. This combination of NAVSIM with a weather object allows a detailed investigation of situations where conflicts exist between planned flight routes and adverse weather. The first objective is to simulate the observed circum-navigation in NAVSIM. Real occurring routes will be compared with simulated ones. Once this has successfully completed, NAVSIM offers a platform to assess existing rules and develop more efficient strategies to cope with adverse weather. An overview will be given over the implementation status of weather objects within NAVSIM and first results will be presented. Cb-object data provision by A. Tafferner, C. Forster, T. Zinner, K. Kober, M. Hagen (DLR Oberpfaffenhofen) is greatly acknowledged. References: Eurocontrol, VDL Mode 2 Capacity Analysis through Simulations: WP3.B - NAVSIM Overview and Validation Results, Edition 1.2, 2005 Kober K. and A. Tafferner. Tracking and nowcasting of convective cells using remote sensing data from radar and satellite, Meteorologische Zeitschrift, 1 (No. 18), 75-84, 2009 Tafferner A. and C. Forster, Improvement of thunderstorm hazard information for pilots through a ground based weather information and management system, Eighth USA/Europe Air Traffic Management Research and Development Seminar (submitted), 2009 Zinner, T., H. Mannstein, A. Tafferner. Cb-TRAM: Tracking and monitoring severe convection from onset over rapid development to mature phase using multi-channel Meteosat-8 SEVIRI data, Meteorol. Atmos. Phys., 101, 191-210, 2008

Comet/Asteroid Protection System (CAPS): A Space-Based System Concept for Revolutionizing Earth Protection and Utilization of Near-Earth Objects

NASA Technical Reports Server (NTRS)

Mazanek, Daniel D.; Roithmayr, Carlos M.; Antol, Jeffrey; Kay-Bunnell, Linda; Werner, Martin R.; Park, Sang-Young; Kumar, Renjith R.

2002-01-01

There exists an infrequent, but significant hazard to life and property due to impacting asteroids and comets. There is currently no specific search for long-period comets, smaller near-Earth asteroids, or smaller short-period comets. These objects represent a threat with potentially little or no warning time using conventional ground-based telescopes. These planetary bodies also represent a significant resource for commercial exploitation, long-term sustained space exploration, and scientific research. The Comet/Asteroid Protection System (CAPS) would expand the current detection effort to include long-period comets, as well as small asteroids and short-period comets capable of regional destruction. A space-based detection system, despite being more costly and complex than Earth-based initiatives, is the most promising way of expanding the range of detectable objects, and surveying the entire celestial sky on a regular basis. CAPS is a future spacebased system concept that provides permanent, continuous asteroid and comet monitoring, and rapid, controlled modification of the orbital trajectories of selected bodies. CAPS would provide an orbit modification system capable of diverting kilometer class objects, and modifying the orbits of smaller asteroids for impact defense and resource utilization. This paper provides a summary of CAPS and discusses several key areas and technologies that are being investigated.

Non-visual spatial tasks reveal increased interactions with stance postural control.

PubMed

Woollacott, Marjorie; Vander Velde, Timothy

2008-05-07

The current investigation aimed to contrast the level and quality of dual-task interactions resulting from the combined performance of a challenging primary postural task and three specific, yet categorically dissociated, secondary central executive tasks. Experiments determined the extent to which modality (visual vs. auditory) and code (non-spatial vs. spatial) specific cognitive resources contributed to postural interference in young adults (n=9) in a dual-task setting. We hypothesized that the different forms of executive n-back task processing employed (visual-object, auditory-object and auditory-spatial) would display contrasting levels of interactions with tandem Romberg stance postural control, and that interactions within the spatial domain would be revealed as most vulnerable to dual-task interactions. Across all cognitive tasks employed, including auditory-object (aOBJ), auditory-spatial (aSPA), and visual-object (vOBJ) tasks, increasing n-back task complexity produced correlated increases in verbal reaction time measures. Increasing cognitive task complexity also resulted in consistent decreases in judgment accuracy. Postural performance was significantly influenced by the type of cognitive loading delivered. At comparable levels of cognitive task difficulty (n-back demands and accuracy judgments) the performance of challenging auditory-spatial tasks produced significantly greater levels of postural sway than either the auditory-object or visual-object based tasks. These results suggest that it is the employment of limited non-visual spatially based coding resources that may underlie previously observed visual dual-task interference effects with stance postural control in healthy young adults.

Apparatuses and Methods for Producing Runtime Architectures of Computer Program Modules

NASA Technical Reports Server (NTRS)

Abi-Antoun, Marwan Elia (Inventor); Aldrich, Jonathan Erik (Inventor)

2013-01-01

Apparatuses and methods for producing run-time architectures of computer program modules. One embodiment includes creating an abstract graph from the computer program module and from containment information corresponding to the computer program module, wherein the abstract graph has nodes including types and objects, and wherein the abstract graph relates an object to a type, and wherein for a specific object the abstract graph relates the specific object to a type containing the specific object; and creating a runtime graph from the abstract graph, wherein the runtime graph is a representation of the true runtime object graph, wherein the runtime graph represents containment information such that, for a specific object, the runtime graph relates the specific object to another object that contains the specific object.

Infrared Telescope Facility's Spectrograph Observations of Human-Made Space Objects

NASA Technical Reports Server (NTRS)

Abercromby, K.; Buckalew, B.; Abell, P.; Cowardin, H.

2015-01-01

Presented here are the results of the Infrared Telescope Facility (IRTF) spectral observations of human-made space objects taken from 2006 to 2008. The data collected using the SpeX infrared spectrograph cover the wavelength range 0.7-2.5 micrometers. Overall, data were collected on 20 different orbiting objects at or near the geosynchronous (GEO) regime. Four of the objects were controlled spacecraft, seven were non-controlled spacecraft, five were rocket bodies, and the final four were cataloged as debris pieces. The remotely collected data are compared to the laboratory-collected reflectance data on typical spacecraft materials, thereby general materials are identified but not specific types. These results highlight the usefulness of observations in the infrared by focusing on features from hydrocarbons, silicon, and thermal emission. The spacecraft, both the controlled and non-controlled, show distinct features due to the presence of solar panels, whereas the rocket bodies do not. Signature variations between rocket bodies, due to the presence of various metals and paints on their surfaces, show a clear distinction from those objects with solar panels, demonstrating that one can distinguish most spacecraft from rocket bodies through infrared spectrum analysis. Finally, the debris pieces tend to show featureless, dark spectra. These results show that the laboratory data in its current state give excellent indications as to the nature of the surface materials on the objects. Further telescopic data collection and model updates to include noise, surface roughness, and material degradation are necessary to make better assessments of orbital object material types. However, based on the current state of the comparison between the observations and the laboratory data, infrared spectroscopic data are adequate to classify objects in GEO as spacecraft, rocket bodies, or debris.

Development of clean coal and clean soil technologies using advanced agglomeration technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ignasiak, B.; Pawlak, W.; Szymocha, K.

1990-04-01

The specific objectives of the bituminous coal program were to explore and evaluate the application of advanced agglomeration technology for: (1)desulphurization of bituminous coals to sulphur content acceptable within the current EPA SO{sub 2} emission guidelines; (2) deashing of bituminous coals to ash content of less than 10 percent; and (3)increasing the calorific value of bituminous coals to above 13,000 Btu/lb. (VC)

The optimization air separation plants for combined cycle MHD-power plant applications

NASA Technical Reports Server (NTRS)

Juhasz, A. J.; Springmann, H.; Greenberg, R.

1980-01-01

Some of the design approaches being employed during a current supported study directed at developing an improved air separation process for the production of oxygen enriched air for magnetohydrodynamics (MHD) combustion are outlined. The ultimate objective is to arrive at conceptual designs of air separation plants, optimized for minimum specific power consumption and capital investment costs, for integration with MHD combined cycle power plants.

Development of Geriatric Mental Health Learning Objectives for Medical Students: A Response to the Institute of Medicine 2012 Report.

PubMed

Lehmann, Susan W; Brooks, William B; Popeo, Dennis; Wilkins, Kirsten M; Blazek, Mary C

2017-10-01

America is aging as the population of older adults increases. The shortage of geriatric mental health specialists means that most geriatric mental healthcare will be provided by physicians who do not have specialty training in geriatrics. The Institute of Medicine Report of 2012 highlighted the urgent need for development of national competencies and curricula in geriatric mental health for all clinicians. Virtually all physicians can expect to treat older patients with mental health symptoms, yet currently there are no widely accepted learning objectives in geriatric mental health specific for medical students. The authors describe the development of a set of such learning objectives that all medical students should achieve by graduation. The iterative process included initial drafting by content experts from five medical schools with input and feedback from a wider group of geriatric psychiatrists, geriatricians, internists, and medical educators. The final document builds upon previously published work and includes specific knowledge, attitudes and skills in six key domains: Normal Aging, Mental Health Assessment of the Geriatric Patient, Psychopharmacology, Delirium, Depression, and Dementia. These objectives address a pressing need, providing a framework for national standards and curriculum development. Copyright © 2017 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Tire Crumb Research Study Literature Review / Gap ...

EPA Pesticide Factsheets

In order to more fully understand data gaps in human exposure and toxicity to tire crumb materials, ATSDR, CPSC and EPA undertook a collaborative effort in the form of a scientific literature review and subsequent gaps analysis. The first objective of the Literature Review and Gap Analysis (LRGA) collaboration was to identify the existing body of literature related specifically to human exposure to tire crumb materials through the use of synthetic turf athletic fields and playgrounds. The second objective was to characterize and summarize the relevant data from the scientific literature. The final objective was to review the summary information and identify data gaps to build on the current understanding of the state-of-the-science and inform the development of specific research efforts that would be most impactful in the near-term. Because of the need for additional information, the U.S. Environmental Protection Agency (EPA), the Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (ATSDR), and the U.S. Consumer Product Safety Commission (CPSC) launched a multi-agency action plan to study key environmental human health questions. The Federal Research Action Plan includes numerous activities, including research studies (U.S. EPA, 2016). A key objective of the Action Plan is to identify key knowledge gaps.

A survey on object detection in optical remote sensing images

NASA Astrophysics Data System (ADS)

Cheng, Gong; Han, Junwei

2016-07-01

Object detection in optical remote sensing images, being a fundamental but challenging problem in the field of aerial and satellite image analysis, plays an important role for a wide range of applications and is receiving significant attention in recent years. While enormous methods exist, a deep review of the literature concerning generic object detection is still lacking. This paper aims to provide a review of the recent progress in this field. Different from several previously published surveys that focus on a specific object class such as building and road, we concentrate on more generic object categories including, but are not limited to, road, building, tree, vehicle, ship, airport, urban-area. Covering about 270 publications we survey (1) template matching-based object detection methods, (2) knowledge-based object detection methods, (3) object-based image analysis (OBIA)-based object detection methods, (4) machine learning-based object detection methods, and (5) five publicly available datasets and three standard evaluation metrics. We also discuss the challenges of current studies and propose two promising research directions, namely deep learning-based feature representation and weakly supervised learning-based geospatial object detection. It is our hope that this survey will be beneficial for the researchers to have better understanding of this research field.

Asthma Cases Attributable to Atopy: Results from the Third National Health and Nutrition Examination Survey

PubMed Central

Arbes, Samuel J.; Gergen, Peter J.; Vaughn, Ben; Zeldin, Darryl C.

2008-01-01

Background The percentage of asthma cases attributable to atopy is the subject of debate. Objectives The objectives were to estimate the percentage of asthma cases in the U.S. population attributable to atopy and to examine associations between allergen-specific skin tests and asthma. Methods Data were obtained from NHANES III in which subjects aged 6–59 years were skin tested with 10 allergens. Atopy was defined as at least one positive allergen-specific test. Doctor-diagnosed current asthma was assessed by questionnaire. Results In the U.S., 56.3% of the asthma cases were attributable to atopy, and that percentage was greater among males than females, among persons in the highest education category than in lower education categories, and among persons living in highly populated metropolitan areas than in all other areas. Each allergen-specific test was strongly associated with asthma before adjustment (odds ratios varied from 2.1 to 4.5); however, after adjustment by all the allergens, only tests to cat, Alternaria, white oak, and perennial rye were independently associated with asthma. Perennial rye was inversely associated with asthma. Of the 10 allergens, a positive response to cat accounted for the highest percentage of asthma cases (29.3%). Conclusions About half of the current asthma cases in the U.S. population represented by NHANES III were attributable to atopy. Some allergen-specific skin tests were not independently associated with asthma. Clinical Implications If atopy could be prevented or reversed, or its effect on asthma blocked, then a large percentage of asthma cases in the U.S. population could be prevented. PMID:17889931

Intra-individual diagnostic image quality and organ-specific-radiation dose comparison between spiral cCT with iterative image reconstruction and z-axis automated tube current modulation and sequential cCT.

PubMed

Wenz, Holger; Maros, Máté E; Meyer, Mathias; Gawlitza, Joshua; Förster, Alex; Haubenreisser, Holger; Kurth, Stefan; Schoenberg, Stefan O; Groden, Christoph; Henzler, Thomas

2016-01-01

To prospectively evaluate image quality and organ-specific-radiation dose of spiral cranial CT (cCT) combined with automated tube current modulation (ATCM) and iterative image reconstruction (IR) in comparison to sequential tilted cCT reconstructed with filtered back projection (FBP) without ATCM. 31 patients with a previous performed tilted non-contrast enhanced sequential cCT aquisition on a 4-slice CT system with only FBP reconstruction and no ATCM were prospectively enrolled in this study for a clinical indicated cCT scan. All spiral cCT examinations were performed on a 3rd generation dual-source CT system using ATCM in z-axis direction. Images were reconstructed using both, FBP and IR (level 1-5). A Monte-Carlo-simulation-based analysis was used to compare organ-specific-radiation dose. Subjective image quality for various anatomic structures was evaluated using a 4-point Likert-scale and objective image quality was evaluated by comparing signal-to-noise ratios (SNR). Spiral cCT led to a significantly lower (p < 0.05) organ-specific-radiation dose in all targets including eye lense. Subjective image quality of spiral cCT datasets with an IR reconstruction level 5 was rated significantly higher compared to the sequential cCT acquisitions (p < 0.0001). Consecutive mean SNR was significantly higher in all spiral datasets (FBP, IR 1-5) when compared to sequential cCT with a mean SNR improvement of 44.77% (p < 0.0001). Spiral cCT combined with ATCM and IR allows for significant-radiation dose reduction including a reduce eye lens organ-dose when compared to a tilted sequential cCT while improving subjective and objective image quality.

HOLLOTRON switch for megawatt lightweight space inverters

NASA Technical Reports Server (NTRS)

Poeschel, R. L.; Goebel, D. M.; Schumacher, R. W.

1991-01-01

The feasibility of satisfying the switching requirements for a megawatt ultralight inverter system using HOLLOTRON switch technology was determined. The existing experimental switch hardware was modified to investigate a coaxial HOLLOTRON switch configuration and the results were compared with those obtained for a modified linear HOLLOTRON configuration. It was concluded that scaling the HOLLOTRON switch to the current and voltage specifications required for a megawatt converter system is indeed feasible using a modified linear configuration. The experimental HOLLOTRON switch operated at parameters comparable to the scaled coaxial HOLLOTRON. However, the linear HOLLOTRON data verified the capability for meeting all the design objectives simultaneously including current density (greater than 2 A/sq cm), voltage (5 kV), switching frequency (20 kHz), switching time (300 ns), and forward voltage drop (less than or equal to 20 V). Scaling relations were determined and a preliminary design was completed for an engineering model linear HOLLOTRON switch to meet the megawatt converter system specifications.

Evaluation of SIR-B imagery for geologic and geomorphic mapping, hydrology, and oceanography in Australia

NASA Technical Reports Server (NTRS)

Honey, F. R.; Simpson, C. J.; Huntington, J.; Horwitz, R.; Byrne, G.; Nilsson, C.

1984-01-01

The objectives of a study to evaluate the potential of Shuttle Imaging Radar-B (SIR-B) imagery for various applications are outlined. Specific goals include: the development of techniques for registration multiple acquisition, varied illumination, and incidence-angle SIR-B imagery, and a model for estimation of the relative contributions to the backscattered radiation of topography, surface roughness, and dielectric and conductivity components; (2) the evaluation of SIR-B imagery for delineation of agricultural lands affected by secondary salinity in the southwest and southeast agricultural regions of Australia; (3) the development of techniques for application of SIR-B imagery for geologic, geomorphologic and soils mapping and mineral exploration; and (4) the evaluation of the use of SIR-B imagery in determining ocean currents, current shear patterns, internal waves and bottom features for specific locations off the Australian coast.

Emerging Opportunities for Serotypes of Botulinum Neurotoxins

PubMed Central

Peng Chen, Zhongxing; Morris, J. Glenn; Rodriguez, Ramon L.; Shukla, Aparna Wagle; Tapia-Núñez, John; Okun, Michael S.

2012-01-01

Background: Two decades ago, botulinum neurotoxin (BoNT) type A was introduced to the commercial market. Subsequently, the toxin was approved by the FDA to address several neurological syndromes, involving muscle, nerve, and gland hyperactivity. These syndromes have typically been associated with abnormalities in cholinergic transmission. Despite the multiplicity of botulinal serotypes (designated as types A through G), therapeutic preparations are currently only available for BoNT types A and B. However, other BoNT serotypes are under study for possible clinical use and new clinical indications; Objective: To review the current research on botulinum neurotoxin serotypes A-G, and to analyze potential applications within basic science and clinical settings; Conclusions: The increasing understanding of botulinal neurotoxin pathophysiology, including the neurotoxin’s effects on specific neuronal populations, will help us in tailoring treatments for specific diagnoses, symptoms and patients. Scientists and clinicians should be aware of the full range of available data involving neurotoxin subtypes A-G. PMID:23202312

Theta oscillations promote temporal sequence learning.

PubMed

Crivelli-Decker, Jordan; Hsieh, Liang-Tien; Clarke, Alex; Ranganath, Charan

2018-05-17

Many theoretical models suggest that neural oscillations play a role in learning or retrieval of temporal sequences, but the extent to which oscillations support sequence representation remains unclear. To address this question, we used scalp electroencephalography (EEG) to examine oscillatory activity over learning of different object sequences. Participants made semantic decisions on each object as they were presented in a continuous stream. For three "Consistent" sequences, the order of the objects was always fixed. Activity during Consistent sequences was compared to "Random" sequences that consisted of the same objects presented in a different order on each repetition. Over the course of learning, participants made faster semantic decisions to objects in Consistent, as compared to objects in Random sequences. Thus, participants were able to use sequence knowledge to predict upcoming items in Consistent sequences. EEG analyses revealed decreased oscillatory power in the theta (4-7 Hz) band at frontal sites following decisions about objects in Consistent sequences, as compared with objects in Random sequences. The theta power difference between Consistent and Random only emerged in the second half of the task, as participants were more effectively able to predict items in Consistent sequences. Moreover, we found increases in parieto-occipital alpha (10-13 Hz) and beta (14-28 Hz) power during the pre-response period for objects in Consistent sequences, relative to objects in Random sequences. Linear mixed effects modeling revealed that single trial theta oscillations were related to reaction time for future objects in a sequence, whereas beta and alpha oscillations were only predictive of reaction time on the current trial. These results indicate that theta and alpha/beta activity preferentially relate to future and current events, respectively. More generally our findings highlight the importance of band-specific neural oscillations in the learning of temporal order information. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Alcohol-Specific Parenting as a Mechanism of Parental Drinking and Alcohol Use Disorder Risk on Adolescent Alcohol Use Onset

PubMed Central

Handley, Elizabeth D.; Chassin, Laurie

2013-01-01

Objective: The primary aim of the current study was to examine three dimensions of alcohol-specific parenting (anti-alcohol parenting strategies, parental legitimacy in regulating adolescent drinking, and parental disclosure of negative alcohol experiences) as mechanisms in the prospective relations between parental drinking and alcohol use disorder (recovered, current, and never diagnosed) and adolescent alcohol use initiation. Method: Participants were from an ongoing longitudinal study of the intergenerational transmission of alcoholism. Structural equation modeling was used to test a maternal model (n = 268 adolescents and their mothers) and a paternal model (n = 204 adolescents and their fathers) of alcohol-specific parenting. Results: Results indicated that higher levels of drinking among mothers and current alcohol use disorder among fathers were related to more frequent parental disclosure of personal negative experiences with alcohol. Maternal disclosure of negative alcohol experiences mediated the effect of maternal drinking on adolescent onset of alcohol use such that more disclosure predicted a greater likelihood of adolescent drinking initiation at follow-up over and above general parenting. In addition, currently alcoholic mothers were perceived as having less legitimate authority to regulate adolescent drinking, and low levels of legitimacy among fathers was predictive of drinking onset among adolescents. Conclusions: Alcohol-specific parenting is a distinct and influential predictor of adolescent alcohol use initiation that is partially shaped by parents’ own drinking experiences. Moreover, parental conversations about their own personal experiences with alcohol may not represent a form of parent–child communication about drinking that deters adolescent drinking. PMID:23948527

Exercise barriers and preferences among women and men with multiple sclerosis.

PubMed

Asano, Miho; Duquette, Pierre; Andersen, Ross; Lapierre, Yves; Mayo, Nancy E

2013-03-01

The primary objective of this study was to estimate the extent to which women and men with MS present different exercise barriers. The secondary objective was to estimate the extent to which women and men with MS present different perceived-health, depressive symptoms, and current exercise routines or preferences. This was a cross sectional survey. 417 people with MS completed a survey of exercise barriers and current exercise routines, perceived-health and depressive symptoms. The top three exercise barriers were: too tired; impairment; and lack of time, regardless of their gender. Regardless of their gender, three times/week and 60 min/session was identified as the most common current exercise structure among physically active participants. The top three currently preferred exercise by men included walking, strengthening/weights and flexibility/stretch exercise. Women reported the same three exercises but flexibility/stretch exercise were slightly more popular than other exercise. Similarities in perceived health status and depressive symptoms were seen between women and men; expect more men were diagnosed with progressive MS (20% higher) than women, leading to a higher rate of men reporting problems with mobility. Women and men with MS differed very little on exercise barriers and current exercise routines, perceived health and depressive symptoms. Even though MS is generally considered a woman's disease, this study did not find a strong need to develop gender specific exercise or physical activity interventions for this population.

CICADA, CCD and Instrument Control Software

NASA Astrophysics Data System (ADS)

Young, Peter J.; Brooks, Mick; Meatheringham, Stephen J.; Roberts, William H.

Computerised Instrument Control and Data Acquisition (CICADA) is a software system for control of telescope instruments in a distributed computing environment. It is designed using object-oriented techniques and built with standard computing tools such as RPC, SysV IPC, Posix threads, Tcl, and GUI builders. The system is readily extensible to new instruments and currently supports the Astromed 3200 CCD controller and MSSSO's new tip-tilt system. Work is currently underway to provide support for the SDSU CCD controller and MSSSO's Double Beam Spectrograph. A core set of processes handle common communication and control tasks, while specific instruments are ``bolted'' on using C++ inheritance techniques.

Association of Various Components of Media Literacy and Adolescent Smoking

PubMed Central

Primack, Brian A.; Hobbs, Renee

2010-01-01

Objective To determine which specific aspects of media literacy were most strongly associated with smoking outcomes. Methods Students at a public high school responded to cross-sectional survey items measuring smoking outcomes, components of media literacy, and other variables. Results Of the 1211 participants, 19% were current smokers (N = 216) and 40% of the nonsmokers (N = 342) were susceptible to smoking. In the adjusted models, current smoking was most strongly related to representation-reality domain items, but susceptibility to smoking was associated with each of the media literacy domains. Conclusion Varied relationships exist between individual facets of media literacy and smoking outcomes. PMID:18844513

Modeling Of Object- And Scene-Prototypes With Hierarchically Structured Classes

NASA Astrophysics Data System (ADS)

Ren, Z.; Jensch, P.; Ameling, W.

1989-03-01

The success of knowledge-based image analysis methodology and implementation tools depends largely on an appropriately and efficiently built model wherein the domain-specific context information about and the inherent structure of the observed image scene have been encoded. For identifying an object in an application environment a computer vision system needs to know firstly the description of the object to be found in an image or in an image sequence, secondly the corresponding relationships between object descriptions within the image sequence. This paper presents models of image objects scenes by means of hierarchically structured classes. Using the topovisual formalism of graph and higraph, we are currently studying principally the relational aspect and data abstraction of the modeling in order to visualize the structural nature resident in image objects and scenes, and to formalize. their descriptions. The goal is to expose the structure of image scene and the correspondence of image objects in the low level image interpretation. process. The object-based system design approach has been applied to build the model base. We utilize the object-oriented programming language C + + for designing, testing and implementing the abstracted entity classes and the operation structures which have been modeled topovisually. The reference images used for modeling prototypes of objects and scenes are from industrial environments as'well as medical applications.

Real-time classification of vehicles by type within infrared imagery

NASA Astrophysics Data System (ADS)

Kundegorski, Mikolaj E.; Akçay, Samet; Payen de La Garanderie, Grégoire; Breckon, Toby P.

2016-10-01

Real-time classification of vehicles into sub-category types poses a significant challenge within infra-red imagery due to the high levels of intra-class variation in thermal vehicle signatures caused by aspects of design, current operating duration and ambient thermal conditions. Despite these challenges, infra-red sensing offers significant generalized target object detection advantages in terms of all-weather operation and invariance to visual camouflage techniques. This work investigates the accuracy of a number of real-time object classification approaches for this task within the wider context of an existing initial object detection and tracking framework. Specifically we evaluate the use of traditional feature-driven bag of visual words and histogram of oriented gradient classification approaches against modern convolutional neural network architectures. Furthermore, we use classical photogrammetry, within the context of current target detection and classification techniques, as a means of approximating 3D target position within the scene based on this vehicle type classification. Based on photogrammetric estimation of target position, we then illustrate the use of regular Kalman filter based tracking operating on actual 3D vehicle trajectories. Results are presented using a conventional thermal-band infra-red (IR) sensor arrangement where targets are tracked over a range of evaluation scenarios.

Development of a Repeatable Protocol to Uniformly Coat Internal Complex Geometries of Fine Featured 3D Printed Objects with Ceramic Material, including Determination of Viscosity Limits to Properly Coat Certain Pore Sizes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, A.

HEPA filters are commonly used in air filtration systems ranging in application from simple home systems to the more advanced networks used in research and development. Currently, these filters are most often composed of glass fibers with diameter on the order of one micron with polymer binders. These fibers, as well as the polymers used, are known to be fragile and can degrade or become extremely brittle with heat, severely limiting their use in high temperature applications. Ceramics are one promising alternative and can enhance the filtration capabilities compared to the current technology. Because ceramic materials are more thermally resistantmore » and chemically stable, there is great interest in developing a repeatable protocol to uniformly coat fine featured polymer objects with ceramic material for use as a filter. The purpose of this experiment is to determine viscosity limits that are able to properly coat certain pore sizes in 3D printed objects, and additionally to characterize the coatings themselves. Latex paint was used as a surrogate because it is specifically designed to produce uniform coatings.« less

The Role of Academic Motivation in High School Students’ Current and Lifetime Alcohol Consumption: Adopting a Self-Determination Theory Perspective*

PubMed Central

Wormington, Stephanie V.; Anderson, Kristen G.; Corpus, Jennifer Henderlong

2011-01-01

Objective: The current study investigated the relationship between different types of academic motives—specifically, intrinsic motivation, introjected regulation, and external regulation—and high school students' current and lifetime alcohol consumption. Method: One thousand sixty-seven high school students completed measures of academic motivation, other school-related factors, and lifetime and current alcohol consumption. Results: Using structural equation modeling, different types of motivation and school-related factors were differentially related to student drinking. Specifically, intrinsic motivation was negatively related to lifetime and current alcohol consumption. External regulation, on the other hand, was positively associated with current drinking. Grade point average was the only school-related factor related to student alcohol use. Conclusions: These findings suggest that motivation is an important construct to consider in predicting students’ alcohol use, even when other more commonly studied educational variables are considered. In addition, it supports the adoption of a motivation framework that considers different types of motivation in understanding the relationship between academic motivation and alcohol use. Suggestions for incorporating the self-determination model of motivation into studies of alcohol and substance use, as well as potential impacts on intervention efforts, are discussed. In particular, it may be important to foster only certain types of motivation, rather than all types of academically-focused motives, in efforts to deter alcohol use. PMID:22051210

WE-H-207B-03: MRI Guidance in the Radiation Therapy Clinic: Site-Specific Discussions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shang, C.

2016-06-15

In recent years, steady progress has been made towards the implementation of MRI in external beam radiation therapy for processes ranging from treatment simulation to in-room guidance. Novel procedures relying mostly on MR data are currently implemented in the clinic. This session will cover topics such as (a) commissioning and quality control of the MR in-room imagers and simulators specific to RT, (b) treatment planning requirements, constraints and challenges when dealing with various MR data, (c) quantification of organ motion with an emphasis on treatment delivery guidance, and (d) MR-driven strategies for adaptive RT workflows. The content of the sessionmore » was chosen to address both educational and practical key aspects of MR guidance. Learning Objectives: Good understanding of MR testing recommended for in-room MR imaging as well as image data validation for RT chain (e.g. image transfer, filtering for consistency, spatial accuracy, manipulation for task specific); Familiarity with MR-based planning procedures: motivation, core workflow requirements, current status, challenges; Overview of the current methods for the quantification of organ motion; Discussion on approaches for adaptive treatment planning and delivery. T. Stanescu - License agreement with Modus Medical Devices to develop a phantom for the quantification of MR image system-related distortions.; T. Stanescu, N/A.« less

Mission operations systems for planetary exploration

NASA Technical Reports Server (NTRS)

Mclaughlin, William I.; Wolff, Donna M.

1988-01-01

The purpose of the paper is twofold: (1) to present an overview of the processes comprising planetary mission operations as conducted at the Jet Propulsion Laboratory, and (2) to present a project-specific and historical context within which this evolving process functions. In order to accomplish these objectives, the generic uplink and downlink functions are described along with their specialization to current flight projects. Also, new multimission capabilities are outlined, including prototyping of advanced-capability software for subsequent incorporation into more automated future operations. Finally, a specific historical ground is provided by listing some major operations software plus a genealogy of planetary missions beginning with Mariner 2 in 1962.

Sodium Sulfur Technology Program Nastec

NASA Technical Reports Server (NTRS)

Highley, Bob; Somerville, W. Andrew

1992-01-01

The NaSTEC program focuses on developing currently available sodium sulfur cells for use in space applications and investigating the operational parameters of the cells. The specific goals of the program are to determine the operational parameters and verify safety limits of Na/S technology battery cells; test long term zero-g operation; and create a life test database. The program approach and ground and flight test objectives are described in textual and graphic form.

Resources of Near-Earth Space: Abstracts

NASA Technical Reports Server (NTRS)

1991-01-01

The objectives are by theory, experiment, and bench-level testing of small systems, to develop scientifically-sound engineering processes and facility specifications for producing propellants and fuels, construction and shielding materials, and life support substances from the lithospheres and atmospheres of lunar, planetary, and asteroidal bodies. Current emphasis is on the production of oxygen, other usefull gases, metallic, ceramic/composite, and related byproducts from lunar regolith, carbonaceous chrondritic asteroids, and the carbon dioxide rich Martian atmosphere.

Four Common Simplifications of Multi-Criteria Decision Analysis do not hold for River Rehabilitation

PubMed Central

2016-01-01

River rehabilitation aims at alleviating negative effects of human impacts such as loss of biodiversity and reduction of ecosystem services. Such interventions entail difficult trade-offs between different ecological and often socio-economic objectives. Multi-Criteria Decision Analysis (MCDA) is a very suitable approach that helps assessing the current ecological state and prioritizing river rehabilitation measures in a standardized way, based on stakeholder or expert preferences. Applications of MCDA in river rehabilitation projects are often simplified, i.e. using a limited number of objectives and indicators, assuming linear value functions, aggregating individual indicator assessments additively, and/or assuming risk neutrality of experts. Here, we demonstrate an implementation of MCDA expert preference assessments to river rehabilitation and provide ample material for other applications. To test whether the above simplifications reflect common expert opinion, we carried out very detailed interviews with five river ecologists and a hydraulic engineer. We defined essential objectives and measurable quality indicators (attributes), elicited the experts´ preferences for objectives on a standardized scale (value functions) and their risk attitude, and identified suitable aggregation methods. The experts recommended an extensive objectives hierarchy including between 54 and 93 essential objectives and between 37 to 61 essential attributes. For 81% of these, they defined non-linear value functions and in 76% recommended multiplicative aggregation. The experts were risk averse or risk prone (but never risk neutral), depending on the current ecological state of the river, and the experts´ personal importance of objectives. We conclude that the four commonly applied simplifications clearly do not reflect the opinion of river rehabilitation experts. The optimal level of model complexity, however, remains highly case-study specific depending on data and resource availability, the context, and the complexity of the decision problem. PMID:26954353

Wireless powering of e -swimmers

NASA Astrophysics Data System (ADS)

Roche, Jérome; Carrara, Serena; Sanchez, Julien; Lannelongue, Jérémy; Loget, Gabriel; Bouffier, Laurent; Fischer, Peer; Kuhn, Alexander

2014-10-01

Miniaturized structures that can move in a controlled way in solution and integrate various functionalities are attracting considerable attention due to the potential applications in fields ranging from autonomous micromotors to roving sensors. Here we introduce a concept which allows, depending on their specific design, the controlled directional motion of objects in water, combined with electronic functionalities such as the emission of light, sensing, signal conversion, treatment and transmission. The approach is based on electric field-induced polarization, which triggers different chemical reactions at the surface of the object and thereby its propulsion. This results in a localized electric current that can power in a wireless way electronic devices in water, leading to a new class of electronic swimmers (e-swimmers).

Planetary Image Geometry Library

NASA Technical Reports Server (NTRS)

Deen, Robert C.; Pariser, Oleg

2010-01-01

The Planetary Image Geometry (PIG) library is a multi-mission library used for projecting images (EDRs, or Experiment Data Records) and managing their geometry for in-situ missions. A collection of models describes cameras and their articulation, allowing application programs such as mosaickers, terrain generators, and pointing correction tools to be written in a multi-mission manner, without any knowledge of parameters specific to the supported missions. Camera model objects allow transformation of image coordinates to and from view vectors in XYZ space. Pointing models, specific to each mission, describe how to orient the camera models based on telemetry or other information. Surface models describe the surface in general terms. Coordinate system objects manage the various coordinate systems involved in most missions. File objects manage access to metadata (labels, including telemetry information) in the input EDRs and RDRs (Reduced Data Records). Label models manage metadata information in output files. Site objects keep track of different locations where the spacecraft might be at a given time. Radiometry models allow correction of radiometry for an image. Mission objects contain basic mission parameters. Pointing adjustment ("nav") files allow pointing to be corrected. The object-oriented structure (C++) makes it easy to subclass just the pieces of the library that are truly mission-specific. Typically, this involves just the pointing model and coordinate systems, and parts of the file model. Once the library was developed (initially for Mars Polar Lander, MPL), adding new missions ranged from two days to a few months, resulting in significant cost savings as compared to rewriting all the application programs for each mission. Currently supported missions include Mars Pathfinder (MPF), MPL, Mars Exploration Rover (MER), Phoenix, and Mars Science Lab (MSL). Applications based on this library create the majority of operational image RDRs for those missions. A Java wrapper around the library allows parts of it to be used from Java code (via a native JNI interface). Future conversions of all or part of the library to Java are contemplated.

A Highly Predictive Model for Diagnosis of Colorectal Neoplasms Using Plasma MicroRNA: Improving Specificity and Sensitivity

PubMed Central

Carter, Jane V.; Roberts, Henry L.; Pan, Jianmin; Rice, Jonathan D.; Burton, James F.; Galbraith, Norman J.; Eichenberger, M. Robert; Jorden, Jeffery; Deveaux, Peter; Farmer, Russell; Williford, Anna; Kanaan, Ziad; Rai, Shesh N.; Galandiuk, Susan

2016-01-01

OBJECTIVE(S) Develop a plasma-based microRNA (miRNA) diagnostic assay specific for colorectal neoplasms, building upon our prior work. BACKGROUND Colorectal neoplasms (colorectal cancer [CRC] and colorectal advanced adenoma [CAA]) frequently develop in individuals at ages when other common cancers also occur. Current screening methods lack sensitivity, specificity, and have poor patient compliance. METHODS Plasma was screened for 380 miRNAs using microfluidic array technology from a “Training” cohort of 60 patients, (10 each) control, CRC, CAA, breast (BC), pancreatic (PC) and lung (LC) cancer. We identified uniquely dysregulated miRNAs specific for colorectal neoplasia (p<0.05, false discovery rate: 5%, adjusted α=0.0038). These miRNAs were evaluated using single assays in a “Test” cohort of 120 patients. A mathematical model was developed to predict blinded sample identity in a 150 patient “Validation” cohort using repeat-sub-sampling validation of the testing dataset with 1000 iterations each to assess model detection accuracy. RESULTS Seven miRNAs (miR-21, miR-29c, miR-122, miR-192, miR-346, miR-372, miR-374a) were selected based upon p-value, area-under-the-curve (AUC), fold-change, and biological plausibility. AUC (±95% CI) for “Test” cohort comparisons were 0.91 (0.85-0.96), 0.79 (0.70-0.88) and 0.98 (0.96-1.0), respectively. Our mathematical model predicted blinded sample identity with 69-77% accuracy between all neoplasia and controls, 67-76% accuracy between colorectal neoplasia and other cancers, and 86-90% accuracy between colorectal cancer and colorectal adenoma. CONCLUSIONS Our plasma miRNA assay and prediction model differentiates colorectal neoplasia from patients with other neoplasms and from controls with higher sensitivity and specificity compared to current clinical standards. PMID:27471839

Late cortical positivity and cardiac responsitivity in female dental phobics when exposed to phobia-relevant pictures

PubMed Central

Leutgeb, Verena; Schäfer, Axel; Schienle, Anne

2011-01-01

Objectives Dental phobia is currently classified as a specific phobia of the blood-injection-injury (BII) subtype. In another subtype, animal phobia, enhanced amplitudes of late event-related potentials have consistently been identified for patients during passive viewing of disorder-relevant pictures. However, this has not been shown for BII phobics, and studies with dental phobics are lacking. Findings on cardiac responses in BII phobia during exposure are heterogeneous, as some studies showed a diphasic pattern of heart rate acceleration and deceleration, whereas others observed pure acceleration. In contrast, heart rate increase has consistently been shown for dental phobics, resembling the reaction of animal phobics. Moreover, the BII subtype is characterized by elevated disgust reactivity whereas the role of habitual disgust proneness in dental phobia is unclear. Methods We recorded the electroencephalogram and the electrocardiogram from 18 dental phobic and 18 healthy women while they watched pictures depicting dental treatment, disgust, fear and neutral items. Results Phobics relative to controls showed an enhanced late positive potential (300–700 ms) and heart rate acceleration towards phobic material, reflecting motivated attention and fear. Affective ratings revealed that dental phobics experienced significantly higher levels of fear than disgust during exposure to phobia-relevant material. Patients' elevated habitual disgust proneness was restricted to specific domains, such as the oral incorporation of offensive objects. Conclusion The psychophysiology of dental phobia resembles the fear-dominated subtypes of specific phobia reported in earlier studies. Future studies should continue to investigate whether the current classification of this disorder as BII phobia needs to be reconsidered. PMID:21238507

SU-F-R-46: Predicting Distant Failure in Lung SBRT Using Multi-Objective Radiomics Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Z; Folkert, M; Iyengar, P

2016-06-15

Purpose: To predict distant failure in lung stereotactic body radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) by using a new multi-objective radiomics model. Methods: Currently, most available radiomics models use the overall accuracy as the objective function. However, due to data imbalance, a single object may not reflect the performance of a predictive model. Therefore, we developed a multi-objective radiomics model which considers both sensitivity and specificity as the objective functions simultaneously. The new model is used to predict distant failure in lung SBRT using 52 patients treated at our institute. Quantitative imaging features of PETmore » and CT as well as clinical parameters are utilized to build the predictive model. Image features include intensity features (9), textural features (12) and geometric features (8). Clinical parameters for each patient include demographic parameters (4), tumor characteristics (8), treatment faction schemes (4) and pretreatment medicines (6). The modelling procedure consists of two steps: extracting features from segmented tumors in PET and CT; and selecting features and training model parameters based on multi-objective. Support Vector Machine (SVM) is used as the predictive model, while a nondominated sorting-based multi-objective evolutionary computation algorithm II (NSGA-II) is used for solving the multi-objective optimization. Results: The accuracy for PET, clinical, CT, PET+clinical, PET+CT, CT+clinical, PET+CT+clinical are 71.15%, 84.62%, 84.62%, 85.54%, 82.69%, 84.62%, 86.54%, respectively. The sensitivities for the above seven combinations are 41.76%, 58.33%, 50.00%, 50.00%, 41.67%, 41.67%, 58.33%, while the specificities are 80.00%, 92.50%, 90.00%, 97.50%, 92.50%, 97.50%, 97.50%. Conclusion: A new multi-objective radiomics model for predicting distant failure in NSCLC treated with SBRT was developed. The experimental results show that the best performance can be obtained by combining all features.« less

Estimating Children's Soil/Dust Ingestion Rates through ...

EPA Pesticide Factsheets

Background: Soil/dust ingestion rates are important variables in assessing children’s health risks in contaminated environments. Current estimates are based largely on soil tracer methodology, which is limited by analytical uncertainty, small sample size, and short study duration. Objectives: The objective was to estimate site-specific soil/dust ingestion rates through reevaluation of the lead absorption dose–response relationship using new bioavailability data from the Bunker Hill Mining and Metallurgical Complex Superfund Site (BHSS) in Idaho, USA. Methods: The U.S. Environmental Protection Agency (EPA) in vitro bioavailability methodology was applied to archived BHSS soil and dust samples. Using age-specific biokinetic slope factors, we related bioavailable lead from these sources to children’s blood lead levels (BLLs) monitored during cleanup from 1988 through 2002. Quantitative regression analyses and exposure assessment guidance were used to develop candidate soil/dust source partition scenarios estimating lead intake, allowing estimation of age-specific soil/dust ingestion rates. These ingestion rate and bioavailability estimates were simultaneously applied to the U.S. EPA Integrated Exposure Uptake Biokinetic Model for Lead in Children to determine those combinations best approximating observed BLLs. Results: Absolute soil and house dust bioavailability averaged 33% (SD ± 4%) and 28% (SD ± 6%), respectively. Estimated BHSS age-specific soil/du

Maternal Immune Activation Alters Nonspatial Information Processing in the Hippocampus of the Adult Offspring

PubMed Central

Ito, Hiroshi T.; Smith, Stephen E. P.; Hsiao, Elaine; Patterson, Paul H.

2010-01-01

The observation that maternal infection increases the risk for schizophrenia in the offspring suggests that the maternal immune system plays a key role in the etiology of schizophrenia. In a mouse model, maternal immune activation (MIA) by injection of poly(I:C) yields adult offspring that display abnormalities in a variety of behaviors relevant to schizophrenia. As abnormalities in the hippocampus are a consistent observation in schizophrenia patients, we examined synaptic properties in hippocampal slices prepared from the offspring of poly(I:C)- and saline-treated mothers. Compared to controls, CA1 pyramidal neurons from adult offspring of MIA mothers display reduced frequency and increased amplitude of miniature excitatory postsynaptic currents. In addition, the specific component of the temporoammonic pathway that mediates object-related information displays increased sensitivity to dopamine. To assess hippocampal network function in vivo, we used expression of the immediate early gene, c-Fos, as a surrogate measure of neuronal activity. Compared to controls, the offspring of poly(I:C)-treated mothers display a distinct c-Fos expression pattern in area CA1 following novel object, but not novel location, exposure. Thus, the offspring of MIA mothers may have an abnormality in modality-specific information processing. Indeed, the MIA offspring display enhanced discrimination in a novel object recognition, but not in an object location, task. Thus, analysis of object and spatial information processing at both synaptic and behavioral levels reveals a largely selective abnormality in object information processing in this mouse model. Our results suggest that altered processing of object-related information may be part of the pathogenesis of schizophrenia-like cognitive behaviors. PMID:20227486

Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring.

PubMed

Ito, Hiroshi T; Smith, Stephen E P; Hsiao, Elaine; Patterson, Paul H

2010-08-01

The observation that maternal infection increases the risk for schizophrenia in the offspring suggests that the maternal immune system plays a key role in the etiology of schizophrenia. In a mouse model, maternal immune activation (MIA) by injection of poly(I:C) yields adult offspring that display abnormalities in a variety of behaviors relevant to schizophrenia. As abnormalities in the hippocampus are a consistent observation in schizophrenia patients, we examined synaptic properties in hippocampal slices prepared from the offspring of poly(I:C)- and saline-treated mothers. Compared to controls, CA1 pyramidal neurons from adult offspring of MIA mothers display reduced frequency and increased amplitude of miniature excitatory postsynaptic currents. In addition, the specific component of the temporoammonic pathway that mediates object-related information displays increased sensitivity to dopamine. To assess hippocampal network function in vivo, we used expression of the immediate-early gene, c-Fos, as a surrogate measure of neuronal activity. Compared to controls, the offspring of poly(I:C)-treated mothers display a distinct c-Fos expression pattern in area CA1 following novel object, but not novel location, exposure. Thus, the offspring of MIA mothers may have an abnormality in modality-specific information processing. Indeed, the MIA offspring display enhanced discrimination in a novel object recognition, but not in an object location, task. Thus, analysis of object and spatial information processing at both synaptic and behavioral levels reveals a largely selective abnormality in object information processing in this mouse model. Our results suggest that altered processing of object-related information may be part of the pathogenesis of schizophrenia-like cognitive behaviors. Copyright 2010 Elsevier Inc. All rights reserved.

Current Practices in Hosting Non-US Pharmacy Students at US Pharmacy Schools in Experiential Clerkships

PubMed Central

Al-Dahir, Sara; Alsharif, Naser Z.; Gleason, Shaun E.; Tofade, Toyin; Flores, Emily K.; Katz, Michael; Dornblaser, Emily K.

2017-01-01

Objective: To provide specific considerations for hosting non-U.S. pharmacy students at U.S.-based colleges/schools of pharmacy (C/SOP) for experiential clerkships and training. Findings: A literature review (2000-2016) in PubMed, Google Scholar and IPA databases was conducted using specific keywords. Recommendations and future directions for development of experiential rotations for non-U.S. students in U.S. experiential rotations are presented for both the home and host country. Summary articles and best practices across the disciplines, as well as expert opinion, were found across U.S. models for hosting non-U.S. students in advanced practice rotations in the medical disciplines. Consistent themes regarding legal agreements, acculturation, standardized calendars and social and safety considerations were considered for inclusion in the final document. Conclusion: Development of a successful experiential rotation/training for non-U.S. students requires consideration for well-developed objectives, qualified preceptors, multitude of legal and cultural considerations and recommendations for longevity and sustainability. PMID:29302084

Does the Internet assist clients to carry out contact tracing? A randomized controlled trial using web-based information.

PubMed

Tomnay, J E; Pitts, M K; Kuo, T C; Fairley, C K

2006-06-01

The primary outcome was to determine the acceptability of the Internet, specifically a website for use in standard partner notification. A secondary objective was to determine if a website would enhance the outcomes of currently used partner notification methods. In a randomized control trial, 105 participants diagnosed with chlamydia and non-gonoccocal urethritis (NGU) were randomized and 97 completed the study. About 30% of participants were provided a standard partner letter and 70% were provided the standard partner letter and website. All participants reported that their partners had no objections to the website (0%, 95% confidence interval [CI] 0-5%). There were no complaints received from any partner. The odds ratio for contacting partners was not significantly different between the two groups of participants. The results of this study indicate that providing a website with specific information about the infection to which a partner has been exposed is not harmful.

Site-Specific Analyses for Demonstrating Compliance with 10 CFR 61 Performance Objectives - 12179

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grossman, C.J.; Esh, D.W.; Yadav, P.

2012-07-01

The U.S. Nuclear Regulatory Commission (NRC) is proposing to amend its regulations at 10 CFR Part 61 to require low-level radioactive waste disposal facilities to conduct site-specific analyses to demonstrate compliance with the performance objectives in Subpart C. The amendments would require licensees to conduct site-specific analyses for protection of the public and inadvertent intruders as well as analyses for long-lived waste. The amendments would ensure protection of public health and safety, while providing flexibility to demonstrate compliance with the performance objectives, for current and potential future waste streams. NRC staff intends to submit proposed rule language and associated regulatorymore » basis to the Commission for its approval in early 2012. The NRC staff also intends to develop associated guidance to accompany any proposed amendments. The guidance is intended to supplement existing low-level radioactive waste guidance on issues pertinent to conducting site-specific analyses to demonstrate compliance with the performance objectives. The guidance will facilitate implementation of the proposed amendments by licensees and assist competent regulatory authorities in reviewing the site-specific analyses. Specifically, the guidance provides staff recommendations on general considerations for the site-specific analyses, modeling issues for assessments to demonstrate compliance with the performance objectives including the performance assessment, intruder assessment, stability assessment, and analyses for long-lived waste. This paper describes the technical basis for changes to the rule language and the proposed guidance associated with implementation of the rule language. The NRC staff, per Commission direction, intends to propose amendments to 10 CFR Part 61 to require licensees to conduct site-specific analyses to demonstrate compliance with performance objectives for the protection of public health and the environment. The amendments would require a performance assessment to demonstrate protection of the general population from releases of radioactivity, an assessment to demonstrate protection of a potential inadvertent intruder, and a long-term analysis to assess how the design of the facility considers the potential radiological impacts associated with disposal of long-lived waste streams. Concurrently, the NRC staff intends to propose associated guidance to facilitate the implementation of the requirements to conduct site-specific analyses. In proposing these amendments to the regulation and associated guidance, the NRC staff has conducted extensive public outreach since 2009 including three public meetings and four briefings of the NRC's Advisory Committee on Reactor Safeguards. The NRC staff plans to submit the proposed amendments to the regulations to the Commission in early 2012. Subsequently, the proposed amendments and associated guidance would be published in the Federal Register for public comment pending approval of the proposed amendments to the regulations by the Commission. Following the public comment period, NRC staff plans to address public comments and revise, as necessary, the regulations and associated guidance before publishing a final rule, which is anticipated in 2013. (authors)« less

Determining the material type of man-made orbiting objects using low-resolution reflectance spectroscopy

NASA Astrophysics Data System (ADS)

Jorgensen, Kira; Africano, John L.; Stansbery, Eugene G.; Kervin, Paul W.; Hamada, Kris M.; Sydney, Paul F.

2001-12-01

The purpose of this research is to improve the knowledge of the physical properties of orbital debris, specifically the material type. Combining the use of the fast-tracking United States Air Force Research Laboratory (AFRL) telescopes with a common astronomical technique, spectroscopy, and NASA resources was a natural step toward determining the material type of orbiting objects remotely. Currently operating at the AFRL Maui Optical Site (AMOS) is a 1.6-meter telescope designed to track fast moving objects like those found in lower Earth orbit (LEO). Using the spectral range of 0.4 - 0.9 microns (4000 - 9000 angstroms), researchers can separate materials into classification ranges. Within the above range, aluminum, paints, plastics, and other metals have different absorption features as well as slopes in their respective spectra. The spectrograph used on this telescope yields a three-angstrom resolution; large enough to see smaller features mentioned and thus determine the material type of the object. The results of the NASA AMOS Spectral Study (NASS) are presented herein.

United Kingdom Infrared Telescope's Spectrograph Observations of Human-Made Space Objects

NASA Technical Reports Server (NTRS)

Buckalew, Brent; Abercromby, Kira; Lederer, Susan; Cowardin, Heather; Frith, James

2017-01-01

Presented here are the results of the United Kingdom Infrared Telescope (UKIRT) spectral observations of human-made space objects taken from 2014 to 2015. The data collected using the UKIRT 1-5 micron Imager Spectrometer (UIST) cover the wavelength range 0.7-2.5 micrometers. Overall, data were collected on 18 different orbiting objects at or near geosynchronous orbit (GEO). Two of the objects are controlled spacecraft, twelve are non-controlled spacecraft, one is a rocket body, and three are cataloged as debris. The remotely collected data are compared to the laboratory-collected reflectance data on typical spacecraft materials; thereby general materials are identified but not specific types. These results highlight the usefulness of observations in the infrared by focusing on features from hydrocarbons and silicon. The spacecraft, both the controlled and non-controlled, show distinct features due to the presence of solar panels whereas the rocket bodies do not. Signature variations between rocket bodies, due to the presence of various metals and paints on their surfaces, show a clear distinction from those objects with solar panels, demonstrating that one can distinguish most spacecraft from rocket bodies through infrared spectrum analysis. Finally, the debris pieces tend to show featureless, dark spectra. These results show that the laboratory data in its current state give well-correlated indications as to the nature of the surface materials on the objects. Further telescopic data collection and model updates to include noise, surface roughness, and material degradation are necessary to make better assessments of orbital object material types. A comparison conducted between objects observed previously with the NASA Infrared Telescope Facility (IRTF) shows similar materials and trends from the two telescopes and different times. However, based on the current state of the model, infrared spectroscopic data are adequate to classify objects in GEO as spacecraft, rocket bodies, or debris.

Alternative aircraft fuels

NASA Technical Reports Server (NTRS)

Longwell, J. P.; Grobman, J.

1978-01-01

In connection with the anticipated impossibility to provide on a long-term basis liquid fuels derived from petroleum, an investigation has been conducted with the objective to assess the suitability of jet fuels made from oil shale and coal and to develop a data base which will allow optimization of future fuel characteristics, taking energy efficiency of manufacture and the tradeoffs in aircraft and engine design into account. The properties of future aviation fuels are examined and proposed solutions to problems of alternative fuels are discussed. Attention is given to the refining of jet fuel to current specifications, the control of fuel thermal stability, and combustor technology for use of broad specification fuels. The first solution is to continue to develop the necessary technology at the refinery to produce specification jet fuels regardless of the crude source.

The Reviewing of Object Files: Object-Specific Integration of Information.

ERIC Educational Resources Information Center

Kahneman, Daniel; And Others

1992-01-01

Seven experiments involving a total of 203 college students explored a form of object-specific priming and established a robust object-specific benefit that indicates that a new stimulus will be named faster if it physically matches a previous stimulus seen as part of the same perceptual object. (SLD)

Graph-Based Object Class Discovery

NASA Astrophysics Data System (ADS)

Xia, Shengping; Hancock, Edwin R.

We are interested in the problem of discovering the set of object classes present in a database of images using a weakly supervised graph-based framework. Rather than making use of the ”Bag-of-Features (BoF)” approach widely used in current work on object recognition, we represent each image by a graph using a group of selected local invariant features. Using local feature matching and iterative Procrustes alignment, we perform graph matching and compute a similarity measure. Borrowing the idea of query expansion , we develop a similarity propagation based graph clustering (SPGC) method. Using this method class specific clusters of the graphs can be obtained. Such a cluster can be generally represented by using a higher level graph model whose vertices are the clustered graphs, and the edge weights are determined by the pairwise similarity measure. Experiments are performed on a dataset, in which the number of images increases from 1 to 50K and the number of objects increases from 1 to over 500. Some objects have been discovered with total recall and a precision 1 in a single cluster.

The emotional reasoning heuristic in children.

PubMed

Muris, P; Merckelbach, H; van Spauwen, I

2003-03-01

A previous study by Arntz, Rauner, and Van den Hout (1995; Behaviour Research and Therapy, 33, 917-925) has shown that adult anxiety patients tend to infer danger not only on the basis of objective danger information, but also on the basis of anxiety response information. The current study examined whether this so-called emotional reasoning phenomenon also occurs in children. Normal primary school children (N = 101) first completed scales tapping anxiety disorders symptoms, anxiety sensitivity, and trait anxiety. Next, they were asked to rate danger levels of scripts in which objective danger versus objective safety and anxiety response versus no anxiety response were systematically varied. Evidence was found for a general emotional reasoning effect. That is, children's danger ratings were not only a function of objective danger information, but also, in the case of objective safety scripts, by anxiety response information. This emotional reasoning effect was predicted by levels of anxiety sensitivity and trait anxiety. More specifically, high levels of anxiety sensitivity and trait anxiety were accompanied by a greater tendency to use anxiety-response information as an heuristic for assessing dangerousness of safety scripts. Implications of these findings are briefly discussed.

Frontal–Occipital Connectivity During Visual Search

PubMed Central

Pantazatos, Spiro P.; Yanagihara, Ted K.; Zhang, Xian; Meitzler, Thomas

2012-01-01

Abstract Although expectation- and attention-related interactions between ventral and medial prefrontal cortex and stimulus category-selective visual regions have been identified during visual detection and discrimination, it is not known if similar neural mechanisms apply to other tasks such as visual search. The current work tested the hypothesis that high-level frontal regions, previously implicated in expectation and visual imagery of object categories, interact with visual regions associated with object recognition during visual search. Using functional magnetic resonance imaging, subjects searched for a specific object that varied in size and location within a complex natural scene. A model-free, spatial-independent component analysis isolated multiple task-related components, one of which included visual cortex, as well as a cluster within ventromedial prefrontal cortex (vmPFC), consistent with the engagement of both top-down and bottom-up processes. Analyses of psychophysiological interactions showed increased functional connectivity between vmPFC and object-sensitive lateral occipital cortex (LOC), and results from dynamic causal modeling and Bayesian Model Selection suggested bidirectional connections between vmPFC and LOC that were positively modulated by the task. Using image-guided diffusion-tensor imaging, functionally seeded, probabilistic white-matter tracts between vmPFC and LOC, which presumably underlie this effective interconnectivity, were also observed. These connectivity findings extend previous models of visual search processes to include specific frontal–occipital neuronal interactions during a natural and complex search task. PMID:22708993

Plasma properties and heating at the anode of a 1 kW arcjet using electrostatic probes

NASA Astrophysics Data System (ADS)

Tiliakos, Nicholas

A 1 kW hydrazine arcjet thruster has been modified for internal probing of the near-anode boundary layer with an array of fourteen electrostatic micro-probes. The main objectives of this experimental investigation were to: (1) obtain axial and azimuthal distributions of floating potential phisbf, anode sheath potential phisbs, probe current density at zero volts jsba, electron number density nsbes, electron temperature Tsbes, and anode heating due to electrons qsbe for arc currents Isbarc, between 7.8 and 10.6 A, propellant flow rates m = 40-60 mg/s, and specific energies, 18.8 MJ/kg ≤ P/m ≤ 27.4 MJ/kg; (2) probe the anode boundary layer using flush-mounted and cylindrical micro-probes; (3) verify azimuthal current symmetry; (4) understand what affects anode heating, a critical thruster lifetime issue; and (5) provide experimental data for validation of the Megli-Krier-Burton (MKB) model. All of the above objectives were met through the design, fabrication and implementation of fourteen electrostatic micro-probes, of sizes ranging from 0.170 mm to 0.43 mm in diameter. A technique for cleaning and implementing these probes was developed. Two configurations were used: flush-mounted planar probes and cylindrical probes extended 0.10-0.30 mm into the plasma flow. The main results of this investigation are: (1) electrostatic micro-probes can successfully be used in the harsh environment of an arcjet; (2) under all conditions tested the plasma is highly non-equilibrium in the near-anode region; (3) azimuthal current symmetry exists for most operating conditions; (4) the propellant flow rate affects the location of maximum anode sheath potential, current density, and anode heating more than the arc current; (5) the weighted anode sheath potential is always positive and varies from 8-17 V depending on thruster operating conditions; (6) the fraction of anode heating varies from 18-24% of the total input power over the range of specific energies tested; and (7) based on an energy loss factor of delta = 1200, reasonable correlation between the experimental data and the MKB model was found.

Extending DoD Modeling and Simulation with Web 2.0, Ajax and X3D

DTIC Science & Technology

2007-09-01

Supported by Gavin King, who created the well known and industry respected Hibernate , (O/R) Object Relational Mapping tool, which binds Java ...most likely a Hibernate derivative). The preceding is where eBay differs from a pure Java EE specification “by the book” implementation. A truly... Java language has come a long way in providing real world case studies and scalable solutions for the enterprise that are currently in production on

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, M. T.

The overall objective of the current work is to carry out a scoping analysis to determine the impact of ATF on late phase accident progression; in particular, the molten core-concrete interaction portion of the sequence that occurs after the core debris fails the reactor vessel and relocates into containment. This additional study augments previous work by including kinetic effects that govern chemical reaction rates during core-concrete interaction. The specific ATF considered as part of this study is SiC-clad UO 2.

Identifying Military and Combat-Specific Risk Factors for Child Adjustment: Comparing High and Low Risk Military Families and Civilian Families

DTIC Science & Technology

2013-06-01

families (N=200) and civilian dual parent families (N=200). The objectives of this study are to: 1) identify and measure developmentally salient skills ...identify and measure developmentally salient skills that are indicators of current adaptation among preschool and early childhood boys and girls of... Skill Achievement i. Preschool Aged children 1. Self regulation: the 36-item Early Childhood Behavior Questionnaire – Very Short Form (CBQ-VSF

A metadata-driven approach to data repository design.

PubMed

Harvey, Matthew J; McLean, Andrew; Rzepa, Henry S

2017-01-01

The design and use of a metadata-driven data repository for research data management is described. Metadata is collected automatically during the submission process whenever possible and is registered with DataCite in accordance with their current metadata schema, in exchange for a persistent digital object identifier. Two examples of data preview are illustrated, including the demonstration of a method for integration with commercial software that confers rich domain-specific data analytics without introducing customisation into the repository itself.

Uranus and Neptune

NASA Technical Reports Server (NTRS)

Bergstralh, J. T. (Editor)

1984-01-01

A scientific framework within which to plan the Voyager encounters with Uranus and Neptune was sought. Specific objectives were: (1) to assess the current state of knowledge of Uranus and Neptune, their magnetospheres, and their respective systems of satellites and rings (if any), (2) to identify important scientific issues that can be addressed effectively by Voyager, and (3) to provide an opportunity for Voyager investigators to interact with other scientists knowledgeable in the field of physical studies of the Uranian and Neptunian systems.

Object-oriented feature-tracking algorithms for SAR images of the marginal ice zone

NASA Technical Reports Server (NTRS)

Daida, Jason; Samadani, Ramin; Vesecky, John F.

1990-01-01

An unsupervised method that chooses and applies the most appropriate tracking algorithm from among different sea-ice tracking algorithms is reported. In contrast to current unsupervised methods, this method chooses and applies an algorithm by partially examining a sequential image pair to draw inferences about what was examined. Based on these inferences the reported method subsequently chooses which algorithm to apply to specific areas of the image pair where that algorithm should work best.

Multifocal planes head-mounted displays.

PubMed

Rolland, J P; Krueger, M W; Goon, A

2000-07-01

Stereoscopic head-mounted displays (HMD's) provide an effective capability to create dynamic virtual environments. For a user of such environments, virtual objects would be displayed ideally at the appropriate distances, and natural concordant accommodation and convergence would be provided. Under such image display conditions, the user perceives these objects as if they were objects in a real environment. Current HMD technology requires convergent eye movements. However, it is currently limited by fixed visual accommodation, which is inconsistent with real-world vision. A prototype multiplanar volumetric projection display based on a stack of laminated planes was built for medical visualization as discussed in a paper presented at a 1999 Advanced Research Projects Agency workshop (Sullivan, Advanced Research Projects Agency, Arlington, Va., 1999). We show how such technology can be engineered to create a set of virtual planes appropriately configured in visual space to suppress conflicts of convergence and accommodation in HMD's. Although some scanning mechanism could be employed to create a set of desirable planes from a two-dimensional conventional display, multiplanar technology accomplishes such function with no moving parts. Based on optical principles and human vision, we present a comprehensive investigation of the engineering specification of multiplanar technology for integration in HMD's. Using selected human visual acuity and stereoacuity criteria, we show that the display requires at most 27 equally spaced planes, which is within the capability of current research and development display devices, located within a maximal 26-mm-wide stack. We further show that the necessary in-plane resolution is of the order of 5 microm.

Stratified flows in complex terrain

NASA Astrophysics Data System (ADS)

Retallack, Charles

The focus of this dissertation is the study of stratified atmospheric flows in the presence of complex terrain. Two large-scale field study campaigns were carried out, each with a focus on a specific archetypal terrain. Each field study involved the utilization of remote and in-situ atmospheric monitoring devices to collect experimental data. The first of the two field studies focused on pollution transport mechanisms near an escarpment. The analysis aimed to determine the combined effect of the escarpment and ambient density stratification on the flow and aerosol pollution transport. It was found that under specific atmospheric conditions, the escarpment prompted the channeling, down-mixing, and trapping of aerosol pollutant plumes. The objective of the second field campaign was the study of stratified flows in a mountain valley. Analysis revealed that buoyancy driven katabatic currents originating on the surrounding valley slopes created a scenario in which a down-slope gravity current transitioned into an intrusive gravity current. The intrusive gravity current propagated near the interface of a density stratified lower ambient layer and a non-stratified upper ambient layer. A combination of shallow water theory and energy arguments is used to produce a model for the propagation of a gravity current moving along the interface of a homogeneous ambient layer and a linearly stratified layer. It is found that the gravity current propagating entirely within the homogeneous layer travels at the greatest speed. As the relative density of the gravity current is increased, the gravity current begins to slump below the interface of the two layers and the propagation speed decreases.

Physiology informed virtual surgical planning: a case study with a virtual airway surgical planner and BioGears

NASA Astrophysics Data System (ADS)

Potter, Lucas; Arikatla, Sreekanth; Bray, Aaron; Webb, Jeff; Enquobahrie, Andinet

2017-03-01

Stenosis of the upper airway affects approximately 1 in 200,000 adults per year1 , and occurs in neonates as well2 . Its treatment is often dictated by institutional factors and clinicians' experience or preferences 3 . Objective and quantitative methods of evaluating treatment options hold the potential to improve care in stenosis patients. Virtual surgical planning software tools are critically important for this. The Virtual Pediatric Airway Workbench (VPAW) is a software platform designed and evaluated for upper airway stenosis treatment planning. It incorporates CFD simulation and geometric authoring with objective metrics from both that help in informed evaluation and planning. However, this planner currently lacks physiological information which could impact the surgical planning outcomes. In this work, we integrated a lumped parameter, model based human physiological engine called BioGears with VPAW. We demonstrated the use of physiology informed virtual surgical planning platform for patient-specific stenosis treatment planning. The preliminary results show that incorporating patient-specific physiology in the pretreatment plan would play important role in patient-specific surgical trainers and planners in airway surgery and other types of surgery that are significantly impacted by physiological conditions during surgery.

NASA's Hall Thruster Program

NASA Technical Reports Server (NTRS)

Jankovsky, Robert S.; Jacobson, David T.; Rawlin, Vincent K.; Mason, Lee S.; Mantenieks, Maris A.; Manzella, David H.; Hofer, Richard R.; Peterson, Peter Y.

2001-01-01

NASA's Hall thruster program has base research and focused development efforts in support of the Advanced Space Transportation Program, Space-Based Program, and various other programs. The objective of the base research is to gain an improved understanding of the physical processes and engineering constraints of Hall thrusters to enable development of advanced Hall thruster designs. Specific technical questions that are current priorities of the base effort are: (1) How does thruster life vary with operating point? (2) How can thruster lifetime and wear rate be most efficiently evaluated? (3) What are the practical limitations for discharge voltage as it pertains to high specific impulse operation (high discharge voltage) and high thrust operation (low discharge voltage)? (4) What are the practical limits for extending Hall thrusters to very high input powers? and (5) What can be done during thruster design to reduce cost and integration concerns? The objective of the focused development effort is to develop a 50 kW-class Hall propulsion system, with a milestone of a 50 kW engineering model thruster/system by the end of program year 2006. Specific program wear 2001 efforts, along with the corporate and academic participation, are described.

Assessing a nephrology-focused YouTube channel's potential to educate health care providers.

PubMed

Desai, Tejas; Sanghani, Vivek; Fang, Xiangming; Christiano, Cynthia; Ferris, Maria

2013-01-01

YouTube has emerged as a potential teaching tool. Studies of the teaching potential of YouTube videos have not addressed health care provider (HCP) satisfaction; a necessary prerequisite for any teaching tool. We conducted a 4-month investigation to determine HCP satisfaction with a nephrology-specific YouTube channel. The Nephrology On-Demand YouTube channel was analyzed from January 1 through April 30, 2011. Sixty-minute nephrology lectures at East Carolina University were compressed into 10-minute videos and uploaded to the channel. HCPs were asked to answer a 5-point Likert questionnaire regarding the accuracy, currency, objectivity and usefulness of the digital format of the teaching videos. Means, standard deviations and 2-sided chi-square testing were performed to analyze responses. Over 80% of HCPs considered the YouTube channel to be accurate, current and objective. A similar percentage considered the digital format useful despite the compression of videos and lack of audio. The nephrology-specific YouTube channel has the potential to educate HCPs of various training backgrounds. Additional studies are required to determine if such specialty-specific channels can improve knowledge acquisition and retention.

A portable meter for measuring low frequency currents in the human body.

PubMed

Niple, J C; Daigle, J P; Zaffanella, L E; Sullivan, T; Kavet, R

2004-07-01

A portable meter has been developed for measuring low frequency currents that flow in the human body. Although the present version of the meter was specifically designed to measure 50/60 Hz "contact currents," the principles involved can be used with other low frequency body currents. Contact currents flow when the human body provides a conductive path between objects in the environment with different electrical potentials. The range of currents the meter detects is approximately 0.4-800 microA. This provides measurements of currents from the threshold of human perception (approximately 500 microA(RMS)) down to single microampere levels. The meter has a unique design, which utilizes the human subject's body impedance as the sensing element. Some of the advantages of this approach are high sensitivity, the ability to measure current flow in the majority of the body, and relative insensitivity to the current path connection points. Current measurement accuracy varies with the accuracy of the body impedance (resistance) measurement and different techniques can be used to obtain a desired level of accuracy. Techniques are available to achieve an estimated +/-20% accuracy. Copyright 2004 Wiley-Liss, Inc.

Green supplier selection: a new genetic/immune strategy with industrial application

NASA Astrophysics Data System (ADS)

Kumar, Amit; Jain, Vipul; Kumar, Sameer; Chandra, Charu

2016-10-01

With the onset of the 'climate change movement', organisations are striving to include environmental criteria into the supplier selection process. This article hybridises a Green Data Envelopment Analysis (GDEA)-based approach with a new Genetic/Immune Strategy for Data Envelopment Analysis (GIS-DEA). A GIS-DEA approach provides a different view to solving multi-criteria decision making problems using data envelopment analysis (DEA) by considering DEA as a multi-objective optimisation problem with efficiency as one objective and proximity of solution to decision makers' preferences as the other objective. The hybrid approach called GIS-GDEA is applied here to a well-known automobile spare parts manufacturer in India and the results presented. User validation developed based on specific set of criteria suggests that the supplier selection process with GIS-GDEA is more practical than other approaches in a current industrial scenario with multiple decision makers.

Mixing geometric and radiometric features for change classification

NASA Astrophysics Data System (ADS)

Fournier, Alexandre; Descombes, Xavier; Zerubia, Josiane

2008-02-01

Most basic change detection algorithms use a pixel-based approach. Whereas such approach is quite well defined for monitoring important area changes (such as urban growth monitoring) in low resolution images, an object based approach seems more relevant when the change detection is specifically aimed toward targets (such as small buildings and vehicles). In this paper, we present an approach that mixes radiometric and geometric features to qualify the changed zones. The goal is to establish bounds (appearance, disappearance, substitution ...) between the detected changes and the underlying objects. We proceed by first clustering the change map (containing each pixel bitemporal radiosity) in different classes using the entropy-kmeans algorithm. Assuming that most man-made objects have a polygonal shape, a polygonal approximation algorithm is then used in order to characterize the resulting zone shapes. Hence allowing us to refine the primary rough classification, by integrating the polygon orientations in the state space. Tests are currently conducted on Quickbird data.

Visual working memory gives up attentional control early in learning: ruling out interhemispheric cancellation.

PubMed

Reinhart, Robert M G; Carlisle, Nancy B; Woodman, Geoffrey F

2014-08-01

Current research suggests that we can watch visual working memory surrender the control of attention early in the process of learning to search for a specific object. This inference is based on the observation that the contralateral delay activity (CDA) rapidly decreases in amplitude across trials when subjects search for the same target object. Here, we tested the alternative explanation that the role of visual working memory does not actually decline across learning, but instead lateralized representations accumulate in both hemispheres across trials and wash out the lateralized CDA. We show that the decline in CDA amplitude occurred even when the target objects were consistently lateralized to a single visual hemifield. Our findings demonstrate that reductions in the amplitude of the CDA during learning are not simply due to the dilution of the CDA from interhemispheric cancellation. Copyright © 2014 Society for Psychophysiological Research.

The Close-Up Imager Onboard the ESA ExoMars Rover: Objectives, Description, Operations, and Science Validation Activities.

PubMed

Josset, Jean-Luc; Westall, Frances; Hofmann, Beda A; Spray, John; Cockell, Charles; Kempe, Stephan; Griffiths, Andrew D; De Sanctis, Maria Cristina; Colangeli, Luigi; Koschny, Detlef; Föllmi, Karl; Verrecchia, Eric; Diamond, Larryn; Josset, Marie; Javaux, Emmanuelle J; Esposito, Francesca; Gunn, Matthew; Souchon-Leitner, Audrey L; Bontognali, Tomaso R R; Korablev, Oleg; Erkman, Suren; Paar, Gerhard; Ulamec, Stephan; Foucher, Frédéric; Martin, Philippe; Verhaeghe, Antoine; Tanevski, Mitko; Vago, Jorge L

The Close-Up Imager (CLUPI) onboard the ESA ExoMars Rover is a powerful high-resolution color camera specifically designed for close-up observations. Its accommodation on the movable drill allows multiple positioning. The science objectives of the instrument are geological characterization of rocks in terms of texture, structure, and color and the search for potential morphological biosignatures. We present the CLUPI science objectives, performance, and technical description, followed by a description of the instrument's planned operations strategy during the mission on Mars. CLUPI will contribute to the rover mission by surveying the geological environment, acquiring close-up images of outcrops, observing the drilling area, inspecting the top portion of the drill borehole (and deposited fines), monitoring drilling operations, and imaging samples collected by the drill. A status of the current development and planned science validation activities is also given. Key Words: Mars-Biosignatures-Planetary Instrumentation. Astrobiology 17, 595-611.

15-Month-Olds’ Transfer of Learning between Touch Screen and Real-World Displays: Language Cues and Cognitive Loads

PubMed Central

Zack, Elizabeth; Gerhardstein, Peter; Meltzoff, Andrew N.; Barr, Rachel

2012-01-01

Infants have difficulty transferring information between 2D and 3D sources. The current study extends Zack et al.’s (2009) touch screen imitation task to examine whether the addition of specific language cues significantly facilitates 15-month-olds’ transfer of learning between touch screens and real-world 3D objects. The addition of two kinds of linguistic cues (object label plus verb or nonsense name) did not elevate action imitation significantly above levels observed when such language cues were not used. Language cues hindered infants’ performance in the 3D→2D direction of transfer, but only for the object label plus verb condition. The lack of a facilitative effect of language is discussed in terms of competing cognitive loads imposed by conjointly transferring information across dimensions and processing linguistic cues in an action imitation task at this age. PMID:23121508

Feasibility of High-Repetition, Task-Specific Training for Individuals With Upper-Extremity Paresis

PubMed Central

Waddell, Kimberly J.; Birkenmeier, Rebecca L.; Moore, Jennifer L.; Hornby, T. George

2014-01-01

OBJECTIVE. We investigated the feasibility of delivering an individualized, progressive, high-repetition upper-extremity (UE) task-specific training protocol for people with stroke in the inpatient rehabilitation setting. METHOD. Fifteen patients with UE paresis participated in this study. Task-specific UE training was scheduled for 60 min/day, 4 days/wk, during occupational therapy for the duration of a participant’s inpatient stay. During each session, participants were challenged to complete ≥300 repetitions of various tasks. RESULTS. Participants averaged 289 repetitions/session, spending 47 of 60 min in active training. Participants improved on impairment and activity level outcome measures. CONCLUSION. People with stroke in an inpatient setting can achieve hundreds of repetitions of task-specific training in 1-hr sessions. As expected, all participants improved on functional outcome measures. Future studies are needed to determine whether this high-repetition training program results in better outcomes than current UE interventions. PMID:25005508

Limits of Generalization between Categories and Implications for Theories of Category Specificity

PubMed Central

Bukach, Cindy M.; Phillips, W. Stewart; Gauthier, Isabel

2010-01-01

Both domain-specific and expertise accounts of category specialization assume that generalization occurs within a domain but not between domains. Yet it is often difficult to define the boundaries and critical features of object domains. Differences in how categories are defined make it difficult to adjudicate between accounts of category specificity and may lead to contradictory results. For example, evidence for whether car experts recruit the fusiform face area is mixed and this inconsistency may be due to the inclusion of antique cars in one of the studies. The current study tested the generalization of expertise from modern to antique cars and found that modern car experts showed expert discrimination and holistic processing of modern cars, but not antique cars. These findings suggest that the neural specialization underlying perceptual expertise is highly specific and may not generalize to distinct subclasses, even when they share some degree of perceptual and conceptual features. PMID:20952784

Role of the parahippocampal cortex in memory for the configuration but not the identity of objects: converging evidence from patients with selective thermal lesions and fMRI

PubMed Central

Bohbot, Véronique D.; Allen, John J. B.; Dagher, Alain; Dumoulin, Serge O.; Evans, Alan C.; Petrides, Michael; Kalina, Miroslav; Stepankova, Katerina; Nadel, Lynn

2015-01-01

The parahippocampal cortex and hippocampus are brain structures known to be involved in memory. However, the unique contribution of the parahippocampal cortex remains unclear. The current study investigates memory for object identity and memory of the configuration of objects in patients with small thermo-coagulation lesions to the hippocampus or the parahippocampal cortex. Results showed that in contrast to control participants and patients with damage to the hippocampus leaving the parahippocampal cortex intact, patients with lesions that included the right parahippocampal cortex (RPH) were severely impaired on a task that required learning the spatial configuration of objects on a computer screen; these patients, however, were not impaired at learning the identity of objects. Conversely, we found that patients with lesions to the right hippocampus (RH) or left hippocampus (LH), sparing the parahippocampal cortex, performed just as well as the control participants. Furthermore, they were not impaired on the object identity task. In the functional Magnetic Resonance Imaging (fMRI) experiment, healthy young adults performed the same tasks. Consistent with the findings of the lesion study, the fMRI results showed significant activity in the RPH in the memory for the spatial configuration condition, but not memory for object identity. Furthermore, the pattern of fMRI activity measured in the baseline control conditions decreased specifically in the parahippocampal cortex as a result of the experimental task, providing evidence for task specific repetition suppression. In summary, while our previous studies demonstrated that the hippocampus is critical to the construction of a cognitive map, both the lesion and fMRI studies have shown an involvement of the RPH for learning spatial configurations of objects but not object identity, and that this takes place independent of the hippocampus. PMID:26283949

Game On? Smoking Cessation Through the Gamification of mHealth: A Longitudinal Qualitative Study

PubMed Central

Eisingerich, Andreas B

2016-01-01

Background Finding ways to increase and sustain engagement with mHealth interventions has become a challenge during application development. While gamification shows promise and has proven effective in many fields, critical questions remain concerning how to use gamification to modify health behavior. Objective The objective of this study is to investigate how the gamification of mHealth interventions leads to a change in health behavior, specifically with respect to smoking cessation. Methods We conducted a qualitative longitudinal study using a sample of 16 smokers divided into 2 cohorts (one used a gamified intervention and the other used a nongamified intervention). Each participant underwent 4 semistructured interviews over a period of 5 weeks. Semistructured interviews were also conducted with 4 experts in gamification, mHealth, and smoking cessation. Interviews were transcribed verbatim and thematic analysis undertaken. Results Results indicated perceived behavioral control and intrinsic motivation acted as positive drivers to game engagement and consequently positive health behavior. Importantly, external social influences exerted a negative effect. We identified 3 critical factors, whose presence was necessary for game engagement: purpose (explicit purpose known by the user), user alignment (congruency of game and user objectives), and functional utility (a well-designed game). We summarize these findings in a framework to guide the future development of gamified mHealth interventions. Conclusions Gamification holds the potential for a low-cost, highly effective mHealth solution that may replace or supplement the behavioral support component found in current smoking cessation programs. The framework reported here has been built on evidence specific to smoking cessation, however it can be adapted to health interventions in other disease categories. Future research is required to evaluate the generalizability and effectiveness of the framework, directly against current behavioral support therapy interventions in smoking cessation and beyond. PMID:27777216

The Force of Habit: Creating and Sustaining a Wellness Lifestyle.

PubMed

Nemec, Patricia B; Swarbrick, Margaret A; Merlo, David M

2015-09-01

Regardless of an individual's mental health status, habits are difficult to establish and/or eliminate. Given the importance of good habits to overall health and wellness, nurses and other mental health service providers need to understand the force of habits (positive and negative), factors that make habit change difficult, and approaches that are likely to facilitate building and maintaining good habits. The current article provides a cursory overview of several factors (i.e., motivation, will-power, and rewards) that impact habit formation. Relevant theories and research are presented. Habit formation can be fostered through a careful analysis of current behaviors, specific and measurable short-term goals or objectives, and a detailed action plan. Copyright 2015, SLACK Incorporated.

Socioeconomic Impact on the Prevalence of Cardiovascular Risk Factors in Wallonia, Belgium: A Population-Based Study.

PubMed

Streel, Sylvie; Donneau, Anne-Françoise; Hoge, Axelle; Majerus, Sven; Kolh, Philippe; Chapelle, Jean-Paul; Albert, Adelin; Guillaume, Michèle

2015-01-01

Background. Monitoring the epidemiology of cardiovascular risk factors (CRFs) and their determinants is important to develop appropriate recommendations to prevent cardiovascular diseases in specific risk groups. The NESCaV study was designed to collect standardized data to estimate the prevalence of CRFs in relation to socioeconomic parameters among the general adult population in the province of Liège, Wallonia, Belgium. Methods. A representative stratified random sample of 1017 subjects, aged 20-69 years, participated in the NESCaV study (2010-2012). A self-administered questionnaire, a clinical examination, and laboratory tests were performed on participants. CRFs included hypertension, dyslipidemia, global obesity, abdominal obesity, diabetes, current smoking, and physical inactivity. Covariates were education and subjective and objective socioeconomic levels. Data were analyzed by weighted logistic regression. Results. The prevalence of hypertension, abdominal obesity, global obesity, current smoking, and physical inactivity was higher in subjects with low education and who considered themselves "financially in need." Living below poverty threshold also increased the risk of global and abdominal obesity, current smoking, and physical inactivity. Conclusion. The study shows that socioeconomic factors impact the prevalence of CRFs in the adult population of Wallonia. Current public health policies should be adjusted to reduce health inequalities in specific risk groups.

The Design of Operational Amplifier for Low Voltage and Low Current Sound Energy Harvesting System

NASA Astrophysics Data System (ADS)

Fang, Liew Hui; Rahim, Rosemizi Bin Abd; Isa, Muzamir; Idris Syed Hassan, Syed; Ismail, Baharuddin Bin

2018-03-01

The objective of this paper is to design a combination of an operational amplifier (op-amp) with a rectifier used in an alternate current (ac) to direct current (dc) power conversion. The op-amp was designed to specifically work at low voltage and low current for a sound energy harvesting system. The goal of the op-amp design with adjustable gain was to control output voltage based on the objectives of the experiment conducted. The op-amp was designed for minimum power dissipation performance, with the means of increasing the output current when receiving a large amount of load. The harvesting circuits which designed further improved the power output efficiency by shortening the fully charged time needed by a supercapacitor bank. It can fulfil the long-time power demands for low power device. Typically, a small amount of energy sources were converted to electricity and stored in the supercapacitor bank, which was built by 10 pieces of capacitors with 0.22 F each, arranged in parallel connection. The highest capacitance was chosen based on the characteristic that have the longest discharging time to support the applications of a supercapacitor bank. Testing results show that the op-amp can boost the low input ac voltage (∼3.89 V) to high output dc voltage (5.0 V) with output current of 30 mA and stored the electrical energy in a big supercapacitor bank having a total of 2.2 F, effectively. The measured results agree well with the calculated results.

Regulatory Technology Development Plan - Sodium Fast Reactor. Mechanistic Source Term - Trial Calculation. Work Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grabaskas, David; Bucknor, Matthew; Jerden, James

2016-02-01

The overall objective of the SFR Regulatory Technology Development Plan (RTDP) effort is to identify and address potential impediments to the SFR regulatory licensing process. In FY14, an analysis by Argonne identified the development of an SFR-specific MST methodology as an existing licensing gap with high regulatory importance and a potentially long lead-time to closure. This work was followed by an initial examination of the current state-of-knowledge regarding SFR source term development (ANLART-3), which reported several potential gaps. Among these were the potential inadequacies of current computational tools to properly model and assess the transport and retention of radionuclides duringmore » a metal fuel pool-type SFR core damage incident. The objective of the current work is to determine the adequacy of existing computational tools, and the associated knowledge database, for the calculation of an SFR MST. To accomplish this task, a trial MST calculation will be performed using available computational tools to establish their limitations with regard to relevant radionuclide release/retention/transport phenomena. The application of existing modeling tools will provide a definitive test to assess their suitability for an SFR MST calculation, while also identifying potential gaps in the current knowledge base and providing insight into open issues regarding regulatory criteria/requirements. The findings of this analysis will assist in determining future research and development needs.« less

A visual processing advantage for young-adolescent deaf observers: Evidence from face and object matching tasks

PubMed Central

Megreya, Ahmed M.; Bindemann, Markus

2017-01-01

It is unresolved whether the permanent auditory deprivation that deaf people experience leads to the enhanced visual processing of faces. The current study explored this question with a matching task in which observers searched for a target face among a concurrent lineup of ten faces. This was compared with a control task in which the same stimuli were presented upside down, to disrupt typical face processing, and an object matching task. A sample of young-adolescent deaf observers performed with higher accuracy than hearing controls across all of these tasks. These results clarify previous findings and provide evidence for a general visual processing advantage in deaf observers rather than a face-specific effect. PMID:28117407

Ioss IO Subsystem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjaardema, Gregory; Bauer, David; Erik, & Illescas

2017-01-06

The Ioss is a database-independent package for providing an object-oriented, abstract interface to IO capabilities for a finite element application; and concrete database interfaces which provided input and/or output to exodusII, xdmf, generated, and heartbeat database formats. The Ioss provides an object-oriented C++-based IO interface for a finite element application code. The application code can perform all IO operations through the Ioss interface which is typically at a higher abstraction level than the concrete database formats. The Ioss then performs the needed operations to translate the finite element data to the specific format required by the concrete database implementations. Themore » Ioss currently supports interfaces to exodusII, xdmf, generated, and heartbeat formats, but additional formats can be easily added.« less

Soluble biomarkers development in osteoarthritis: from discovery to personalized medicine

PubMed Central

Henrotin, Yves; Sanchez, Christelle; Cornet, Anne; Van de Put, Joachim; Douette, Pierre; Gharbi, Myriam

2015-01-01

Abstract Context: Specific soluble biomarkers could be a precious tool for diagnosis, prognosis and personalized management of osteoarthritic (OA) patients. Objective: To describe the path of soluble biomarker development from discovery to clinical qualification and regulatory adoption toward OA-related biomarker qualification. Methods and results: This review summarizes current guidance on the use of biomarkers in OA in clinical trials and their utility at five stages, including preclinical development and phase 1 to phase 4 trials. It also presents all the available regulatory requirements. Conclusions: The path through the adoption of a specific soluble biomarker for OA is steep but is worth the challenge due to the benefit that it can provide. PMID:26954785

Armed and attentive: holding a weapon can bias attentional priorities in scene viewing.

PubMed

Biggs, Adam T; Brockmole, James R; Witt, Jessica K

2013-11-01

The action-specific perception hypothesis (Witt, Current Directions in Psychological Science 20: 201-206, 2011) claims that the environment is represented with respect to potential interactions for objects present within said environment. This investigation sought to extend the hypothesis beyond perceptual mechanisms and assess whether action-specific potential could alter attentional allocation. To do so, we examined a well-replicated attention bias in the weapon focus effect (Loftus, Loftus, & Messo, Law and Human Behaviour 1, 55-62, 1987), which represents the tendency for observers to attend more to weapons than to neutral objects. Our key manipulation altered the anticipated action-specific potential of observers by providing them a firearm while they freely viewed scenes with and without weapons present. We replicated the original weapon focus effect using modern eye tracking and confirmed that the increase in time looking at weapons comes at a cost of less time spent looking at faces. Additionally, observers who held firearms while viewing the various scenes showed a general bias to look at faces over objects, but only if the firearm was in a readily usable position (i.e., pointed at the scenes rather than holstered at one's side). These two effects, weapon focus and the newly found bias to look more at faces when armed, canceled out one another without interacting. This evidence confirms that the action capabilities of the observer alter more than just perceptual mechanisms and that holding a weapon can change attentional priorities. Theoretical and real-world implications are discussed.

Decoding task-based attentional modulation during face categorization.

PubMed

Chiu, Yu-Chin; Esterman, Michael; Han, Yuefeng; Rosen, Heather; Yantis, Steven

2011-05-01

Attention is a neurocognitive mechanism that selects task-relevant sensory or mnemonic information to achieve current behavioral goals. Attentional modulation of cortical activity has been observed when attention is directed to specific locations, features, or objects. However, little is known about how high-level categorization task set modulates perceptual representations. In the current study, observers categorized faces by gender (male vs. female) or race (Asian vs. White). Each face was perceptually ambiguous in both dimensions, such that categorization of one dimension demanded selective attention to task-relevant information within the face. We used multivoxel pattern classification to show that task-specific modulations evoke reliably distinct spatial patterns of activity within three face-selective cortical regions (right fusiform face area and bilateral occipital face areas). This result suggests that patterns of activity in these regions reflect not only stimulus-specific (i.e., faces vs. houses) responses but also task-specific (i.e., race vs. gender) attentional modulation. Furthermore, exploratory whole-brain multivoxel pattern classification (using a searchlight procedure) revealed a network of dorsal fronto-parietal regions (left middle frontal gyrus and left inferior and superior parietal lobule) that also exhibit distinct patterns for the two task sets, suggesting that these regions may represent abstract goals during high-level categorization tasks.

tDCS over the motor cortex improves lexical retrieval of action words in poststroke aphasia.

PubMed

Branscheidt, Meret; Hoppe, Julia; Zwitserlood, Pienie; Liuzzi, Gianpiero

2018-02-01

One-third of stroke survivors worldwide suffer from aphasia. Speech and language therapy (SLT) is considered effective in treating aphasia, but because of time constraints, improvements are often limited. Noninvasive brain stimulation is a promising adjuvant strategy to facilitate SLT. However, stroke might render "classical" language regions ineffective as stimulation sites. Recent work showed the effectiveness of motor cortex stimulation together with intensive naming therapy to improve outcomes in aphasia (Meinzer et al. 2016). Although that study highlights the involvement of the motor cortex, the functional aspects by which it influences language remain unclear. In the present study, we focus on the role of motor cortex in language, investigating its functional involvement in access to specific lexico-semantic (object vs. action relatedness) information in poststroke aphasia. To this end, we tested effects of anodal transcranial direct current stimulation (tDCS) to the left motor cortex on lexical retrieval in 16 patients with poststroke aphasia in a sham-controlled, double-blind study design. Critical stimuli were action and object words, and pseudowords. Participants performed a lexical decision task, deciding whether stimuli were words or pseudowords. Anodal tDCS improved accuracy in lexical decision, especially for words with action-related content and for pseudowords with an "action-like" ending ( t 15  = 2.65, P = 0.036), but not for words with object-related content and pseudowords with "object-like" characteristics. We show as a proof-of-principle that the motor cortex may play a specific role in access to lexico-semantic content. Thus motor-cortex stimulation may strengthen content-specific word-to-semantic concept associations during language treatment in poststroke aphasia. NEW & NOTEWORTHY The role of motor cortex (MC) in language processing has been debated in both health and disease. Recent work has suggested that MC stimulation together with speech and language therapy enhances outcomes in aphasia. We show that MC stimulation has a differential effect on object- and action-word processing in poststroke aphasia. We propose that MC stimulation may specifically strengthen word-to-semantic concept association in aphasia. Our results potentially provide a way to tailor therapies for language rehabilitation.

Veterans' Pain Management Goals: Changes During the Course of a Peer-led Pain Self-Management Program

PubMed Central

Bauer, Sarah M.; McGuire, Alan B.; Kukla, Marina; McGuire, Shannon; Bair, Matthew J.; Matthias, Marianne S.

2017-01-01

Objective Goal setting is a common element of self-management support programs; however, little is known about the nature of patients' goals or how goals change during pain self-management. The purpose of the current study is to explore how patients' goals and views of goal setting change over the course of a peer-led pain self-management program. Methods Veterans (n = 16) completing a 4-month peer-led pain self-management program completed semi-structured interviews at baseline and follow-up regarding their goals for their pain. Interviews were analyzed using immersion/crystallization. Results Analyses revealed six themes: motivation to do something for their pain, more goal-oriented, actually setting goals, clarity of goal importance, more specific/measurable goal criteria, and more specific/measurable strategies. Conclusion The current analyses illustrate how participants' goals can evolve over the course of a peer-led pain self-management program. Specifically, increased motivation, more openness to using goals, greater clarity of goal importance, more specific and measurable goals and strategies, and the influence of the peer coach relationship were described by participants. Practice implications Pain self-management interventions should emphasize goal setting, and development of specific, measurable goals and plans. Trainings for providers should address the potential for the provider-patient relationship, particularly peer providers, to facilitate motivation and goal setting. PMID:27516437

Effects of transcranial direct current stimulation on the control of finger force during dexterous manipulation in healthy older adults.

PubMed

Parikh, Pranav J; Cole, Kelly J

2015-01-01

The contribution of poor finger force control to age-related decline in manual dexterity is above and beyond ubiquitous behavioral slowing. Altered control of the finger forces can impart unwanted torque on the object affecting its orientation, thus impairing manual performance. Anodal transcranial direct current stimulation (tDCS) over primary motor cortex (M1) has been shown to improve the performance speed on manual tasks in older adults. However, the effects of anodal tDCS over M1 on the finger force control during object manipulation in older adults remain to be fully explored. Here we determined the effects of anodal tDCS over M1 on the control of grip force in older adults while they manipulated an object with an uncertain mechanical property. Eight healthy older adults were instructed to grip and lift an object whose contact surfaces were unexpectedly made more or less slippery across trials using acetate and sandpaper surfaces, respectively. Subjects performed this task before and after receiving anodal or sham tDCS over M1 on two separate sessions using a cross-over design. We found that older adults used significantly lower grip force following anodal tDCS compared to sham tDCS. Friction measured at the finger-object interface remained invariant after anodal and sham tDCS. These findings suggest that anodal tDCS over M1 improved the control of grip force during object manipulation in healthy older adults. Although the cortical networks for representing objects and manipulative actions are complex, the reduction in grip force following anodal tDCS over M1 might be due to a cortical excitation yielding improved processing of object-specific sensory information and its integration with the motor commands for production of manipulative forces. Our findings indicate that tDCS has a potential to improve the control of finger force during dexterous manipulation in older adults.

Detection methods and performance criteria for genetically modified organisms.

PubMed

Bertheau, Yves; Diolez, Annick; Kobilinsky, André; Magin, Kimberly

2002-01-01

Detection methods for genetically modified organisms (GMOs) are necessary for many applications, from seed purity assessment to compliance of food labeling in several countries. Numerous analytical methods are currently used or under development to support these needs. The currently used methods are bioassays and protein- and DNA-based detection protocols. To avoid discrepancy of results between such largely different methods and, for instance, the potential resulting legal actions, compatibility of the methods is urgently needed. Performance criteria of methods allow evaluation against a common standard. The more-common performance criteria for detection methods are precision, accuracy, sensitivity, and specificity, which together specifically address other terms used to describe the performance of a method, such as applicability, selectivity, calibration, trueness, precision, recovery, operating range, limit of quantitation, limit of detection, and ruggedness. Performance criteria should provide objective tools to accept or reject specific methods, to validate them, to ensure compatibility between validated methods, and be used on a routine basis to reject data outside an acceptable range of variability. When selecting a method of detection, it is also important to consider its applicability, its field of applications, and its limitations, by including factors such as its ability to detect the target analyte in a given matrix, the duration of the analyses, its cost effectiveness, and the necessary sample sizes for testing. Thus, the current GMO detection methods should be evaluated against a common set of performance criteria.

ESA activities on satellite laser ranging to non-cooperative objects

NASA Astrophysics Data System (ADS)

Flohrer, Tim; Krag, Holger; Funke, Quirin; Jilete, Beatriz; Mancas, Alexandru

2016-07-01

Satellite laser ranging (SLR) to non-cooperative objects is an emerging technology that can contribute significantly to operational, modelling and mitigation needs set by the space debris population. ESA is conducting various research and development activities in SLR to non-cooperative objects. ESA's Space Situational Awareness (SSA) program supports specific activities in the Space Surveillance and Tracking (SST) segment. Research and development activities with operational aspects are run by ESA's Space Debris Office. At ESA SSA/SST comprises detecting, cataloguing and predicting the objects orbiting the Earth, and the derived applications. SST aims at facilitating research and development of sensor and data processing technologies and of related common components while staying complementary with, and in support of, national and multi-national European initiatives. SST promotes standardisation and interoperability of the technology developments. For SLR these goals are implemented through researching, developing, and deploying an expert centre. This centre shall coordinate the contribution of system-external loosely connected SLR sensors, and shall provide back calibration and expert evaluation support to the sensors. The Space Debris Office at ESA is responsible for all aspects related to space debris in the Agency. It is in charge of providing operational support to ESA and third party missions. Currently, the office studies the potential benefits of laser ranging to space debris objects to resolve close approaches to active satellites, to improve re-entry predictions of time and locations, and the more general SLR support during contingency situations. The office studies the determination of attitude and attitude motion of uncooperative objects with special focus on the combination of SLR, light-curve, and radar imaging data. Generating sufficiently precise information to allow for the acquisition of debris objects by a SLR sensor in a stare-and-chase scenario, or from externally provided orbital information, is also investigated. In our paper we will outline the motivation and objectives, as well as detail the current status of the various and parallel SLR-related SST and Space Debris Office activities at ESA. We will provide an overview on plans for SLR activities in research and development and in operational support. Current gaps in the standardisation of data exchange and sensor interfaces will be addressed, reflecting the need of coordinating multiple stations in all tasks.

Activity in human visual and parietal cortex reveals object-based attention in working memory.

PubMed

Peters, Benjamin; Kaiser, Jochen; Rahm, Benjamin; Bledowski, Christoph

2015-02-25

Visual attention enables observers to select behaviorally relevant information based on spatial locations, features, or objects. Attentional selection is not limited to physically present visual information, but can also operate on internal representations maintained in working memory (WM) in service of higher-order cognition. However, only little is known about whether attention to WM contents follows the same principles as attention to sensory stimuli. To address this question, we investigated in humans whether the typically observed effects of object-based attention in perception are also evident for object-based attentional selection of internal object representations in WM. In full accordance with effects in visual perception, the key behavioral and neuronal characteristics of object-based attention were observed in WM. Specifically, we found that reaction times were shorter when shifting attention to memory positions located on the currently attended object compared with equidistant positions on a different object. Furthermore, functional magnetic resonance imaging and multivariate pattern analysis of visuotopic activity in visual (areas V1-V4) and parietal cortex revealed that directing attention to one position of an object held in WM also enhanced brain activation for other positions on the same object, suggesting that attentional selection in WM activates the entire object. This study demonstrated that all characteristic features of object-based attention are present in WM and thus follows the same principles as in perception. Copyright © 2015 the authors 0270-6474/15/353360-10$15.00/0.

Vehicle-Routing Optimization for Municipal Solid Waste Collection Using Genetic Algorithm: The Case of Southern Nablus City

NASA Astrophysics Data System (ADS)

Assaf, Ramiz; Saleh, Yahya

2017-09-01

Municipalities are responsible for solid waste collectiont for environmental, social and economic purposes. Practices of municipalities should be effective and efficient, with the objectives of reducing the total incurred costs in the solid waste collection network concurrently achieving the highest service level. This study aims at finding the best routes of solid waste collection network in Nablus city-Palestine. More specifically, the study seeks the optimal route that minimizes the total travelled distance by the trucks and hence the resulted costs. The current situation is evaluated and the problem is modelled as a Vehicle Routing Problem (VRP). The VRP is then optimized via a genetic algorithm. Specifically, compared to the current situation, the trucks total travelled distance was reduced by 66%, whereas the collection time was reduced from 7 hours per truck-trip to 2.3 hours. The findings of this study is useful for all municipality policy makers that are responsible for solid waste collection.

Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites

PubMed Central

Doucoure, Souleymane; Mouchet, François; Cournil, Amandine; Le Goff, Gilbert; Cornelie, Sylvie; Roca, Yelin; Giraldez, Mabel Guerra; Simon, Zaira Barja; Loayza, Roxanna; Misse, Dorothée; Flores, Jorge Vargas; Walter, Annie; Rogier, Christophe; Herve, Jean Pierre; Remoue, Franck

2012-01-01

Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites. PMID:22848099

Onboard Inert Gas Generation System/Onboard Oxygen Gas Generation System (OBIGGS/OBOGS) Study. Part 1; Aircraft System Requirements

NASA Technical Reports Server (NTRS)

Reynolds, Thomas L.; Bailey, Delbert B.; Lewinski, Daniel F.; Roseburg, Conrad M.; Palaszewski, Bryan (Technical Monitor)

2001-01-01

The purpose of this technology assessment is to define a multiphase research study program investigating Onboard Inert Gas Generation Systems (OBIGGS) and Onboard Oxygen Generation Systems (OBOGS) that would identify current airplane systems design and certification requirements (Subtask 1); explore state-of-the-art technology (Subtask 2); develop systems specifications (Subtask 3); and develop an initial system design (Subtask 4). If feasible, consideration may be given to the development of a prototype laboratory test system that could potentially be used in commercial transport aircraft (Subtask 5). These systems should be capable of providing inert nitrogen gas for improved fire cargo compartment fire suppression and fuel tank inerting and emergency oxygen for crew and passenger use. Subtask I of this research study, presented herein, defines current production aircraft certification requirements and design objectives necessary to meet mandatory FAA certification requirements and Boeing design and performance specifications. These requirements will be utilized for baseline comparisons for subsequent OBIGGS/OBOGS application evaluations and assessments.

Applications of neural networks to landmark detection in 3-D surface data

NASA Astrophysics Data System (ADS)

Arndt, Craig M.

1992-09-01

The problem of identifying key landmarks in 3-dimensional surface data is of considerable interest in solving a number of difficult real-world tasks, including object recognition and image processing. The specific problem that we address in this research is to identify the specific landmarks (anatomical) in human surface data. This is a complex task, currently performed visually by an expert human operator. In order to replace these human operators and increase reliability of the data acquisition, we need to develop a computer algorithm which will utilize the interrelations between the 3-dimensional data to identify the landmarks of interest. The current presentation describes a method for designing, implementing, training, and testing a custom architecture neural network which will perform the landmark identification task. We discuss the performance of the net in relationship to human performance on the same task and how this net has been integrated with other AI and traditional programming methods to produce a powerful analysis tool for computer anthropometry.

Aging memories: differential decay of episodic memory components.

PubMed

Talamini, Lucia M; Gorree, Eva

2012-05-17

Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent change in the nature of memories may reflect a preferential loss of hippocampus-dependent, configurational information over more cortically based memory components, including memory for individual objects. The current study systematically tests this hypothesis, using a new paradigm that allows the contemporaneous assessment of memory for objects, object pairings, and object-position conjunctions. Retention of each memory component was tested, at multiple intervals, up to 3 mo following encoding. The three memory subtasks adopted the same retrieval paradigm and were matched for initial difficulty. Results show differential decay of the tested episodic memory components, whereby memory for configurational aspects of a scene (objects' co-occurrence and object position) decays faster than memory for featured objects. Interestingly, memory requiring a visually detailed object representation decays at a similar rate as global object recognition, arguing against interpretations based on task difficulty and against the notion that (visual) detail is forgotten preferentially. These findings show that memories undergo qualitative changes as they age. More specifically, event memories become less configurational over time, preferentially losing some of the higher order associations that are dependent on the hippocampus for initial fast encoding. Implications for theories of long-term memory are discussed.

Life satisfaction in middle-aged Koreans: mediating effects of domain-specific self-esteem satisfaction, and sex differences.

PubMed

Park, Hyun-Joo; Lee, Dong-Gwi; Yang, Nan Mee

2014-08-01

The current study was an attempt to examine the interplay between domain-specific self-esteem and life satisfaction with middle-aged Koreans. For four domains (Social/Objective Ability, Positive Characteristics, Interpersonal Relationships, and Family), the mediating effects of the satisfaction index of domain-specific self-esteem between the importance index of domain-specific self-esteem and life satisfaction were tested using structural equation modeling. 364 Koreans in their 40s and 50s were recruited through stratified sampling. Overall, the satisfaction index of domain-specific self-esteem was found to be a strong mediator across all the four domains; for middle-aged Koreans, if they appraised their self-esteem in a given domain as important and they felt satisfied in that domain, their life satisfaction was likely to be higher. Additionally, results of multi-group analysis suggested that the strengths of associations in the model were different between men and women in the Interpersonal Relationships domain.

Controversies in the Hydrosphere: an iBook exploring current global water issues for middle school classrooms

NASA Astrophysics Data System (ADS)

Dufoe, A.; Guertin, L. A.

2012-12-01

This project looks to help teachers utilize iPad technology in their classrooms as an instructional tool for Earth system science and connections to the Big Ideas in Earth Science. The project is part of Penn State University's National Science Foundation (NSF) Targeted Math Science Partnership grant, with one goal of the grant to help current middle school teachers across Pennsylvania engage students with significant and complex questions of Earth science. The free Apple software iBooks Author was used to create an electronic book for the iPad, focusing on a variety of controversial issues impacting the hydrosphere. The iBook includes image slideshows, embedded videos, interactive images and quizzes, and critical thinking questions along Bloom's Taxonomic Scale of Learning Objectives. Outlined in the introductory iBook chapters are the Big Ideas of Earth System Science and an overview of Earth's spheres. Since the book targets the hydrosphere, each subsequent chapter focuses on specific water issues, including glacial melts, aquifer depletion, coastal oil pollution, marine debris, and fresh-water chemical contamination. Each chapter is presented in a case study format that highlights the history of the issue, the development and current status of the issue, and some solutions that have been generated. The next section includes critical thinking questions in an open-ended discussion format that focus on the Big Ideas, proposing solutions for rectifying the situation, and/or assignments specifically targeting an idea presented in the case study chapter. Short, comprehensive multiple-choice quizzes are also in each chapter. Throughout the iBook, students are free to watch videos, explore the content and form their own opinions. As a result, this iBook fulfills the grant objective by engaging teachers and students with an innovative technological presentation that incorporates Earth system science with current case studies regarding global water issues.

Geographical distribution of Musa gracilis Holttum in Peninsular Malaysia

NASA Astrophysics Data System (ADS)

Norfazlina, B.; Wickneswari, R.; Choong, C. Y.

2016-11-01

Musa gracilis (Musaceae) is placed under section Callimusa and was considered endemic to Peninsular Malaysia. The objective of this study was to evaluate the current occurrence of Musa gracilis in Peninsular Malaysia. The coordinates of each population was recorded using the Global Positioning System (GPS) and mapped to show the geographical distribution of Musa gracilis. This study revealed that Musa gracilis exhibits specific pattern of distribution, which exists only in a lowland areas on the eastern and southern part of Peninsular Malaysia.

Conversations: with Carl Pilcher [interview by Johan Benson].

PubMed

Pilcher, C

1998-11-01

An interview with Carl Pilcher, science program director for solar system exploration at NASA, examines NASA's past, present, and planned missions to explore the solar system. Specific questions relate to the status of current and planned missions, science results of the Pathfinder mission to Mars, cooperation with the Japanese space agency, the status of the search for extraterrestrial life in solar system meteoroids and asteroids, mission size for more in-depth exploration, reports of water on the moon, and the exploration of near-Earth objects.

Preschool Children's Memory for Word Forms Remains Stable Over Several Days, but Gradually Decreases after 6 Months.

PubMed

Gordon, Katherine R; McGregor, Karla K; Waldier, Brigitte; Curran, Maura K; Gomez, Rebecca L; Samuelson, Larissa K

2016-01-01

Research on word learning has focused on children's ability to identify a target object when given the word form after a minimal number of exposures to novel word-object pairings. However, relatively little research has focused on children's ability to retrieve the word form when given the target object. The exceptions involve asking children to recall and produce forms, and children typically perform near floor on these measures. In the current study, 3- to 5-year-old children were administered a novel test of word form that allowed for recognition memory and manual responses. Specifically, when asked to label a previously trained object, children were given three forms to choose from: the target, a minimally different form, and a maximally different form. Children demonstrated memory for word forms at three post-training delays: 10 mins (short-term), 2-3 days (long-term), and 6 months to 1 year (very long-term). However, children performed worse at the very long-term delay than the other time points, and the length of the very long-term delay was negatively related to performance. When in error, children were no more likely to select the minimally different form than the maximally different form at all time points. Overall, these results suggest that children remember word forms that are linked to objects over extended post-training intervals, but that their memory for the forms gradually decreases over time without further exposures. Furthermore, memory traces for word forms do not become less phonologically specific over time; rather children either identify the correct form, or they perform at chance.

Effect of tDCS on task relevant and irrelevant perceptual learning of complex objects.

PubMed

Van Meel, Chayenne; Daniels, Nicky; de Beeck, Hans Op; Baeck, Annelies

2016-01-01

During perceptual learning the visual representations in the brain are altered, but these changes' causal role has not yet been fully characterized. We used transcranial direct current stimulation (tDCS) to investigate the role of higher visual regions in lateral occipital cortex (LO) in perceptual learning with complex objects. We also investigated whether object learning is dependent on the relevance of the objects for the learning task. Participants were trained in two tasks: object recognition using a backward masking paradigm and an orientation judgment task. During both tasks, an object with a red line on top of it were presented in each trial. The crucial difference between both tasks was the relevance of the object: the object was relevant for the object recognition task, but not for the orientation judgment task. During training, half of the participants received anodal tDCS stimulation targeted at the lateral occipital cortex (LO). Afterwards, participants were tested on how well they recognized the trained objects, the irrelevant objects presented during the orientation judgment task and a set of completely new objects. Participants stimulated with tDCS during training showed larger improvements of performance compared to participants in the sham condition. No learning effect was found for the objects presented during the orientation judgment task. To conclude, this study suggests a causal role of LO in relevant object learning, but given the rather low spatial resolution of tDCS, more research on the specificity of this effect is needed. Further, mere exposure is not sufficient to train object recognition in our paradigm.

Housing Instability Among Current and Former Welfare Recipients

PubMed Central

Phinney, Robin; Danziger, Sheldon; Pollack, Harold A.; Seefeldt, Kristin

2007-01-01

Objectives. We examined correlates of eviction and homelessness among current and former welfare recipients from 1997 to 2003 in an urban Michigan community. Methods. Longitudinal cohort data were drawn from the Women’s Employment Study, a representative panel study of mothers who were receiving cash welfare in February 1997. We used logistic regression analysis to identify risk factors for both eviction and homelessness over the survey period. Results. Twenty percent (95% confidence interval [CI]=16%, 23%) of respondents were evicted and 12% (95% CI=10%, 15%) experienced homelessness at least once between fall 1997 and fall 2003. Multivariate analyses indicated 2 consistent risk factors: having less than a high school education and having used illicit drugs other than marijuana. Mental and physical health problems were significantly associated with homelessness but not evictions. A multivariate screening algorithm achieved 75% sensitivity and 67% specificity in identifying individuals at risk for homelessness. A corresponding algorithm for eviction achieved 75% sensitivity and 50% specificity. Conclusions. The high prevalence of housing instability among our respondents suggests the need to better target housing assistance and other social services to current and former welfare recipients with identifiable personal problems. PMID:17267717

WE-E-18C-01: Multi-Energy CT: Current Status and Recent Innovations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pelc, N; McCollough, C; Yu, L

2014-06-15

Conventional computed tomography (CT) uses a single polychromatic x-ray spectrum and energy integrating detectors, and produces images whose contrast depends on the effective attenuation coefficient of the broad spectrum beam. This can introduce errors from beam hardening and does not produce the optimal contrast-to-noise ratio. In addition, multiple materials can have the same effective attenuation coefficient, causing different materials to be indistinguishable in conventional CT images. If transmission measurements at two or more energies are obtained, even with polychromatic beams, more specific information about the object can be obtained. If the object does not contain materials with k-edges in themore » spectrum, the x-ray attenuation can be well-approximated by a linear combination of two processes (photoelectric absorption and Compton scattering) or, equivalently, two basis materials. For such cases, two spectral measurements suffice, although additional measurements can provide higher precision. If K-edge materials are present, additional spectral measurements can allow these materials to be isolated. Current commercial implementations use varied approaches, including two sources operating a different kVp, one source whose kVp is rapidly switched in a single scan, and a dual layer detector that can provide spectral information in every reading. Processing of the spectral information can be performed in the raw data domain or in the image domain. The process of calculating the amount of the two basis functions implicitly corrects for beam hardening and therefore can lead to improvements in quantitative accuracy. Information can be extracted to provide material specific information beyond that of conventional CT. This additional information has been shown to be important in several clinical applications, and can also lead to more efficient clinical protocols. Recent innovations in x-ray sources, detectors, and systems have made multi-energy CT much more practical and improved its performance. In addition, this is a very active area of research and further improvements are expected through further technological improvements. Learning Objectives: Basic principles of multi-energy CT Current implementations of mutli-energy CT Data and image analysis methods in multi-energy CT Current clinical applications of dual energy CT5. recent innovations and anticipated advances in multi-energy CT.« less

Medicine clerkships and portable computing: a national survey of internal medicine clerkship directors.

PubMed

Ferenchick, Gary; Solomon, David; Durning, Steven J

2010-01-01

Portable computers are widely used by medical trainees, but there is a lack of data on how these devices are used in clinical education programs. The objective is to define the current use of portable computing in internal medicine clerkships and to determine medicine clerkship directors' perceptions of the current value and future importance of portable computing. A 2006 national survey of institutional members of the Clerkship Directors in Internal Medicine. Eighty-three of 110 (75%) of institutional members responded. An institutional requirement for portable computing was reported by 32 schools (39%), whereas only 13 (16%) provided students with a portable computer. Between 10 and 31 institutions (12-37%) reported student use for patient care activities (i.e. order entry, writing patient notes) and only 2 to 4 institutions (2-5%) required such use. The majority of respondents (59-95%) reported portable computer use for educational activities (i.e., tracking patient problems, knowledge resource), however, only in 5 to 19 (6-23%) were such educational uses required. Fifty-six respondents (68%) reported that portable computer's "added value" for teaching and 61 (73%) reported that portable computers would be important in meeting clerkship objectives in the next 3 years. Of interest, even among the institutions requiring portable computers, only 50% recommended or required specific software. Portable computing is required at 39% of allopathic medical schools in the United States. However required portable computing for specific patient care or educational tasks is uncommon. In addition, guidance on specific software exists in only one half of school requiring portable computers, suggesting informal or unstructured uses of required portable computer's in the remaining half. The educational impact of formal institutional requirements for software versus informal "user-defined" applications is unknown.

Personalized Support for Chronic Conditions

PubMed Central

D’Antrassi, Pierluigi; Ajčević, Miloš; Stellato, Kira; Di Lenarda, Andrea; Marceglia, Sara; Accardo, Agostino

2016-01-01

Summary Objective Solutions for improving management of chronic conditions are under the attention of healthcare systems, due to the increasing prevalence caused by demographic change and better survival, and the relevant impact on healthcare expenditures. The objective of this study was to propose a comprehensive architecture of a mHealth system aimed at boosting the active and informed participation of patients in their care process, while at the same time overcoming the current technical and psychological/clinical issues highlighted by the existing literature. Methods After having studied the current challenges outlined in the literature, both in terms of technological and human requirements, we focused our attention on some specific psychological aspects with a view to providing patients with a comprehensive and personalized solution. Our approach has been reinforced through the results of a preliminary assessment we conducted on 22 patients with chronic conditions. The main goal of such an assessment was to provide a preliminary understanding of their needs in a real context, both in terms of self-awareness and of their predisposition toward the use of IT solutions. Results According to the specific needs and features, such as mindfulness and gamification, which were identified through the literature and the preliminary assessment, we designed a comprehensive open architecture able to provide a tailor-made solution linked to specific individuals’ needs. Conclusion The present study represents the preliminary step towards the development of a solution aimed at enhancing patients’ actual perception and encouraging self-management and self-awareness for a better lifestyle. Future work regards further identification of pathology-related needs and requirements through focus groups including all stakeholders in order to describe the architecture and functionality in greater detail. PMID:27452661

Earlier response assessment in invasive aspergillosis based on the kinetics of serum Aspergillus galactomannan: proposal for a new definition.

PubMed

Nouér, Simone A; Nucci, Marcio; Kumar, Naveen Sanath; Grazziutti, Monica; Barlogie, Bart; Anaissie, Elias

2011-10-01

Current criteria for assessing treatment response of invasive aspergillosis (IA) rely on nonspecific subjective parameters. We hypothesized that an Aspergillus-specific response definition based on the kinetics of serum Aspergillus galactomannan index (GMI) would provide earlier and more objective response assessment. We compared the 6-week European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) response criteria with GMI-based response among 115 cancer patients with IA. Success according to GMI required survival with repeatedly negative GMI for ≥2 weeks. Time to response and agreement between the 2 definitions were the study endpoints. Success according to EORTC/MSG and GMI criteria was observed in 73 patients (63%) and 83 patients (72%), respectively. The GMI-based response was determined at a median of 21 days after treatment initiation (range, 15-41 days), 3 weeks before the EORTC/MSG time point, in 72 (87%) of 83 responders. Agreement between definitions was shown in all 32 nonresponders and in 73 of the 83 responders (91% overall), with an excellent κ correlation coefficient of 0.819. Among 10 patients with discordant response (EORTC/MSG failure, GMI success), 1 is alive without IA 3 years after diagnosis; for the other, aspergillosis could not be detected at autopsy. The presence of other life-threatening complications in the remaining 8 patients indicates that IA had resolved. The Aspergillus-specific GMI-based criteria compare favorably to current response definitions for IA and significantly shorten time to response assessment. These criteria rely on a simple, reproducible, objective, and Aspergillus-specific test and should serve as the primary endpoint in trials of IA.

Training in Post-authorization Pharmacovigilance.

PubMed

Ahuja, Vivek; Sharma, Varun

2010-04-01

Post-authorization pharmacovigilance refers to all the activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems, from the time a product gets the authorization to be marketed in a territory. The ultimate objective of pharmacovigilance is patient safety. To ensure this, any responsible pharmaceutical company will readily vouch for the importance of all these activities, each requiring specific training for efficient and effective execution. Having a well planned job specific training curriculum can help the organization realize its goals and objectives by covering the gaps between current and desired job performance levels and existing competencies of its employees. Apart from this, trainings can help in problem solving, increasing productivity and prepare for and respond to future changes in the organization or job duties. As the pharmaceutical business continues to grow, increasing numbers of skilled people are required to manage resultant increase in pharmacovigilance activities to remain compliant. Thus, the need for training qualified resources to develop into highly skilled pharmacovigilance professionals is the need of the hour. Currently, the supply-demand situation for skilled manpower is highly skewed in favor of the demand, as this field is relatively new in India and elsewhere. It is interesting to note that not many resources, be it internet, literature or books, are available specifically addressing the need of the industry to guide them on training requirements to set up and maintain a competent pharmacovigilance department. This article aims to present a comprehensive perspective on the trainings required in the post authorization scenario pertaining to pharmacovigilance activities and suggest ways to manage these in an efficient way so as to be compliant with the global norms and best practices.

Training in Post-authorization Pharmacovigilance

PubMed Central

Ahuja, Vivek; Sharma, Varun

2010-01-01

Post-authorization pharmacovigilance refers to all the activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems, from the time a product gets the authorization to be marketed in a territory. The ultimate objective of pharmacovigilance is patient safety. To ensure this, any responsible pharmaceutical company will readily vouch for the importance of all these activities, each requiring specific training for efficient and effective execution. Having a well planned job specific training curriculum can help the organization realize its goals and objectives by covering the gaps between current and desired job performance levels and existing competencies of its employees. Apart from this, trainings can help in problem solving, increasing productivity and prepare for and respond to future changes in the organization or job duties. As the pharmaceutical business continues to grow, increasing numbers of skilled people are required to manage resultant increase in pharmacovigilance activities to remain compliant. Thus, the need for training qualified resources to develop into highly skilled pharmacovigilance professionals is the need of the hour. Currently, the supply-demand situation for skilled manpower is highly skewed in favor of the demand, as this field is relatively new in India and elsewhere. It is interesting to note that not many resources, be it internet, literature or books, are available specifically addressing the need of the industry to guide them on training requirements to set up and maintain a competent pharmacovigilance department. This article aims to present a comprehensive perspective on the trainings required in the post authorization scenario pertaining to pharmacovigilance activities and suggest ways to manage these in an efficient way so as to be compliant with the global norms and best practices. PMID:21829787

A single-rate context-dependent learning process underlies rapid adaptation to familiar object dynamics.

PubMed

Ingram, James N; Howard, Ian S; Flanagan, J Randall; Wolpert, Daniel M

2011-09-01

Motor learning has been extensively studied using dynamic (force-field) perturbations. These induce movement errors that result in adaptive changes to the motor commands. Several state-space models have been developed to explain how trial-by-trial errors drive the progressive adaptation observed in such studies. These models have been applied to adaptation involving novel dynamics, which typically occurs over tens to hundreds of trials, and which appears to be mediated by a dual-rate adaptation process. In contrast, when manipulating objects with familiar dynamics, subjects adapt rapidly within a few trials. Here, we apply state-space models to familiar dynamics, asking whether adaptation is mediated by a single-rate or dual-rate process. Previously, we reported a task in which subjects rotate an object with known dynamics. By presenting the object at different visual orientations, adaptation was shown to be context-specific, with limited generalization to novel orientations. Here we show that a multiple-context state-space model, with a generalization function tuned to visual object orientation, can reproduce the time-course of adaptation and de-adaptation as well as the observed context-dependent behavior. In contrast to the dual-rate process associated with novel dynamics, we show that a single-rate process mediates adaptation to familiar object dynamics. The model predicts that during exposure to the object across multiple orientations, there will be a degree of independence for adaptation and de-adaptation within each context, and that the states associated with all contexts will slowly de-adapt during exposure in one particular context. We confirm these predictions in two new experiments. Results of the current study thus highlight similarities and differences in the processes engaged during exposure to novel versus familiar dynamics. In both cases, adaptation is mediated by multiple context-specific representations. In the case of familiar object dynamics, however, the representations can be engaged based on visual context, and are updated by a single-rate process.

Feasibility of real-time location systems in monitoring recovery after major abdominal surgery.

PubMed

Dorrell, Robert D; Vermillion, Sarah A; Clark, Clancy J

2017-12-01

Early mobilization after major abdominal surgery decreases postoperative complications and length of stay, and has become a key component of enhanced recovery pathways. However, objective measures of patient movement after surgery are limited. Real-time location systems (RTLS), typically used for asset tracking, provide a novel approach to monitoring in-hospital patient activity. The current study investigates the feasibility of using RTLS to objectively track postoperative patient mobilization. The real-time location system employs a meshed network of infrared and RFID sensors and detectors that sample device locations every 3 s resulting in over 1 million data points per day. RTLS tracking was evaluated systematically in three phases: (1) sensitivity and specificity of the tracking device using simulated patient scenarios, (2) retrospective passive movement analysis of patient-linked equipment, and (3) prospective observational analysis of a patient-attached tracking device. RTLS tracking detected a simulated movement out of a room with sensitivity of 91% and specificity 100%. Specificity decreased to 75% if time out of room was less than 3 min. All RTLS-tagged patient-linked equipment was identified for 18 patients, but measurable patient movement associated with equipment was detected for only 2 patients (11%) with 1-8 out-of-room walks per day. Ten patients were prospectively monitored using RTLS badges following major abdominal surgery. Patient movement was recorded using patient diaries, direct observation, and an accelerometer. Sensitivity and specificity of RTLS patient tracking were both 100% in detecting out-of-room ambulation and correlated well with direct observation and patient-reported ambulation. Real-time location systems are a novel technology capable of objectively and accurately monitoring patient movement and provide an innovative approach to promoting early mobilization after surgery.

B827 Chemical Synthhesis Project - Industrial Control System Integration - Statement of Work & Specification with Attachments 1-14

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wade, F. E.

The Chemical Synthesis Pilot Process at the Lawrence Livermore National Laboratory (LLNL) Site 300 827 Complex will be used to synthesize small quantities of material to support research and development. The project will modernize and increase current capabilities for chemical synthesis at LLNL. The primary objective of this project is the conversion of a non-automated hands-on process to a remoteoperation process, while providing enhanced batch process step control, stored recipe-specific parameter sets, process variable visibility, monitoring, alarm and warning handling, and comprehensive batch record data logging. This Statement of Work and Specification provides the industrial-grade process control requirements for themore » chemical synthesis batching control system, hereafter referred to as the “Control System” to be delivered by the System Integrator.« less

View-tolerant face recognition and Hebbian learning imply mirror-symmetric neural tuning to head orientation

PubMed Central

Leibo, Joel Z.; Liao, Qianli; Freiwald, Winrich A.; Anselmi, Fabio; Poggio, Tomaso

2017-01-01

SUMMARY The primate brain contains a hierarchy of visual areas, dubbed the ventral stream, which rapidly computes object representations that are both specific for object identity and robust against identity-preserving transformations like depth-rotations [1, 2]. Current computational models of object recognition, including recent deep learning networks, generate these properties through a hierarchy of alternating selectivity-increasing filtering and tolerance-increasing pooling operations, similar to simple-complex cells operations [3, 4, 5, 6]. Here we prove that a class of hierarchical architectures and a broad set of biologically plausible learning rules generate approximate invariance to identity-preserving transformations at the top level of the processing hierarchy. However, all past models tested failed to reproduce the most salient property of an intermediate representation of a three-level face-processing hierarchy in the brain: mirror-symmetric tuning to head orientation [7]. Here we demonstrate that one specific biologically-plausible Hebb-type learning rule generates mirror-symmetric tuning to bilaterally symmetric stimuli like faces at intermediate levels of the architecture and show why it does so. Thus the tuning properties of individual cells inside the visual stream appear to result from group properties of the stimuli they encode and to reflect the learning rules that sculpted the information-processing system within which they reside. PMID:27916522

Managing flood risks in the Mekong Delta: How to address emerging challenges under climate change and socioeconomic developments.

PubMed

Hoang, Long Phi; Biesbroek, Robbert; Tri, Van Pham Dang; Kummu, Matti; van Vliet, Michelle T H; Leemans, Rik; Kabat, Pavel; Ludwig, Fulco

2018-02-24

Climate change and accelerating socioeconomic developments increasingly challenge flood-risk management in the Vietnamese Mekong River Delta-a typical large, economically dynamic and highly vulnerable delta. This study identifies and addresses the emerging challenges for flood-risk management. Furthermore, we identify and analyse response solutions, focusing on meaningful configurations of the individual solutions and how they can be tailored to specific challenges using expert surveys, content analysis techniques and statistical inferences. Our findings show that the challenges for flood-risk management are diverse, but critical challenges predominantly arise from the current governance and institutional settings. The top-three challenges include weak collaboration, conflicting management objectives and low responsiveness to new issues. We identified 114 reported solutions and developed six flood management strategies that are tailored to specific challenges. We conclude that the current technology-centric flood management approach is insufficient given the rapid socioecological changes. This approach therefore should be adapted towards a more balanced management configuration where technical and infrastructural measures are combined with institutional and governance resolutions. Insights from this study contribute to the emerging repertoire of contemporary flood management solutions, especially through their configurations and tailoring to specific challenges.

[Definition and biomarkers of acute renal damage: new perspectives].

PubMed

Seijas, M; Baccino, C; Nin, N; Lorente, J A

2014-01-01

The RIFLE and AKIN criteria have definitely help out to draw attention to the relationship between a deterioration of renal function that produces a small increase in serum creatinine and a worse outcome. However, the specific clinical utility of using these criteria remains to be well-defined. It is believed that the main use of these criteria is for the design of epidemiological studies and clinical trials to define inclusion criteria and objectives of an intervention. AKI adopting term, re-summoning former ARF terminology, it is appropriate to describe the clinical condition characterized by damage to kidney, in the same way as the term is used to describe acute lung damage where the lung injury situation still has not increased to a situation of organ failure (dysfunction). The serum and urine biomarkers (creatinine, urea, and diuresis) currently in use are not sensitive or specific for detecting kidney damage, limiting treatment options and potentially compromising the outcome. New biomarkers are being studied in order to diagnose an earlier and more specific AKI, with the potential to change the definition criteria of AKI with different stages, currently based in diuresis and serum creatinine. Copyright © 2013 Elsevier España, S.L. and SEMICYUC. All rights reserved.

X-ray Scatter Imaging of Hepatocellular Carcinoma in a Mouse Model Using Nanoparticle Contrast Agents

NASA Astrophysics Data System (ADS)

Rand, Danielle; Derdak, Zoltan; Carlson, Rolf; Wands, Jack R.; Rose-Petruck, Christoph

2015-10-01

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is almost uniformly fatal. Current methods of detection include ultrasound examination and imaging by CT scan or MRI; however, these techniques are problematic in terms of sensitivity and specificity, and the detection of early tumors (<1 cm diameter) has proven elusive. Better, more specific, and more sensitive detection methods are therefore urgently needed. Here we discuss the application of a newly developed x-ray imaging technique called Spatial Frequency Heterodyne Imaging (SFHI) for the early detection of HCC. SFHI uses x-rays scattered by an object to form an image and is more sensitive than conventional absorption-based x-radiography. We show that tissues labeled in vivo with gold nanoparticle contrast agents can be detected using SFHI. We also demonstrate that directed targeting and SFHI of HCC tumors in a mouse model is possible through the use of HCC-specific antibodies. The enhanced sensitivity of SFHI relative to currently available techniques enables the x-ray imaging of tumors that are just a few millimeters in diameter and substantially reduces the amount of nanoparticle contrast agent required for intravenous injection relative to absorption-based x-ray imaging.

Space Research and Technology Program: Program and specific objectives, document approval

NASA Technical Reports Server (NTRS)

1982-01-01

A detailed view of the Space Research and Technology program work breakdown structure is provided down to the specific objective level. Goals or objectives at each of these levels are set forth. The specific objective narratives are structured into several parts. First, a short paragraph statement of the specific objective is given. This is followed by a list of subobjectives. A list of targets is then provided for those areas of the specific objective that are amenable to a quantitative description of technical accomplishment and schedule. Fluid and thermal physics, materials and structures, computer science and electronics, space energy conversion, multidisciplinary research, controls and human factors, chemical propulsion, spacecraft systems, transportation systems, platform systems, and spacecraft systems technology comprise the principal research programs.

Object discrimination using optimized multi-frequency auditory cross-modal haptic feedback.

PubMed

Gibson, Alison; Artemiadis, Panagiotis

2014-01-01

As the field of brain-machine interfaces and neuro-prosthetics continues to grow, there is a high need for sensor and actuation mechanisms that can provide haptic feedback to the user. Current technologies employ expensive, invasive and often inefficient force feedback methods, resulting in an unrealistic solution for individuals who rely on these devices. This paper responds through the development, integration and analysis of a novel feedback architecture where haptic information during the neural control of a prosthetic hand is perceived through multi-frequency auditory signals. Through representing force magnitude with volume and force location with frequency, the feedback architecture can translate the haptic experiences of a robotic end effector into the alternative sensory modality of sound. Previous research with the proposed cross-modal feedback method confirmed its learnability, so the current work aimed to investigate which frequency map (i.e. frequency-specific locations on the hand) is optimal in helping users distinguish between hand-held objects and tasks associated with them. After short use with the cross-modal feedback during the electromyographic (EMG) control of a prosthetic hand, testing results show that users are able to use audial feedback alone to discriminate between everyday objects. While users showed adaptation to three different frequency maps, the simplest map containing only two frequencies was found to be the most useful in discriminating between objects. This outcome provides support for the feasibility and practicality of the cross-modal feedback method during the neural control of prosthetics.

Developing syndrome definitions based on consensus and current use

PubMed Central

Dowling, John N; Baer, Atar; Buckeridge, David L; Cochrane, Dennis; Conway, Michael A; Elkin, Peter; Espino, Jeremy; Gunn, Julia E; Hales, Craig M; Hutwagner, Lori; Keller, Mikaela; Larson, Catherine; Noe, Rebecca; Okhmatovskaia, Anya; Olson, Karen; Paladini, Marc; Scholer, Matthew; Sniegoski, Carol; Thompson, David; Lober, Bill

2010-01-01

Objective Standardized surveillance syndromes do not exist but would facilitate sharing data among surveillance systems and comparing the accuracy of existing systems. The objective of this study was to create reference syndrome definitions from a consensus of investigators who currently have or are building syndromic surveillance systems. Design Clinical condition–syndrome pairs were catalogued for 10 surveillance systems across the United States and the representatives of these systems were brought together for a workshop to discuss consensus syndrome definitions. Results Consensus syndrome definitions were generated for the four syndromes monitored by the majority of the 10 participating surveillance systems: Respiratory, gastrointestinal, constitutional, and influenza-like illness (ILI). An important element in coming to consensus quickly was the development of a sensitive and specific definition for respiratory and gastrointestinal syndromes. After the workshop, the definitions were refined and supplemented with keywords and regular expressions, the keywords were mapped to standard vocabularies, and a web ontology language (OWL) ontology was created. Limitations The consensus definitions have not yet been validated through implementation. Conclusion The consensus definitions provide an explicit description of the current state-of-the-art syndromes used in automated surveillance, which can subsequently be systematically evaluated against real data to improve the definitions. The method for creating consensus definitions could be applied to other domains that have diverse existing definitions. PMID:20819870

Clinical Applications of Procalcitonin in Pediatrics: An Advanced Biomarker for Inflammation and Infection-Can It Also Be Used in Trauma?

PubMed

Koutroulis, Ioannis; Loscalzo, Steven M; Kratimenos, Panagiotis; Singh, Sabina; Weiner, Evan; Syriopoulou, Vassiliki; Theocharis, Stamatios; Chrousos, Georgios

2014-01-01

Background. Procalcitonin is a small molecular peptide that has gained increased support as an adjunct diagnostic marker of infection in the adult population; the concordant body of evidence for the use of procalcitonin in pediatric populations is far less complete. Objectives. Our objective is to review the current evidence supporting the utilization of procalcitonin in children in a variety of clinical scenarios including SIRS, sepsis, burns, and trauma and to identify existing knowledge gaps. Methods. A thorough review of the literature was performed utilizing PubMed. We focused on using meta-analysis from adult populations to review current practices in interpretation and methodology and find concordant pediatric studies to determine if the same applications are validated in pediatric populations. Results. Current evidence supports the usage of procalcitonin as both a sensitive and a specific marker for the differentiation of systemic inflammatory response syndrome from sepsis in pediatrics with increased diagnostic accuracy compared to commonly used biomarkers including complete blood counts and C-reactive protein. Conclusions. Although the body of evidence is limited, initial observations suggest that procalcitonin can be used in pediatric trauma and burn patients as both a prognostic and a diagnostic marker, aiding in the identification of infection in patients with extensive underlying inflammation.

Clinical Applications of Procalcitonin in Pediatrics: An Advanced Biomarker for Inflammation and Infection—Can It Also Be Used in Trauma?

PubMed Central

Loscalzo, Steven M.; Singh, Sabina; Weiner, Evan; Syriopoulou, Vassiliki; Theocharis, Stamatios; Chrousos, Georgios

2014-01-01

Background. Procalcitonin is a small molecular peptide that has gained increased support as an adjunct diagnostic marker of infection in the adult population; the concordant body of evidence for the use of procalcitonin in pediatric populations is far less complete. Objectives. Our objective is to review the current evidence supporting the utilization of procalcitonin in children in a variety of clinical scenarios including SIRS, sepsis, burns, and trauma and to identify existing knowledge gaps. Methods. A thorough review of the literature was performed utilizing PubMed. We focused on using meta-analysis from adult populations to review current practices in interpretation and methodology and find concordant pediatric studies to determine if the same applications are validated in pediatric populations. Results. Current evidence supports the usage of procalcitonin as both a sensitive and a specific marker for the differentiation of systemic inflammatory response syndrome from sepsis in pediatrics with increased diagnostic accuracy compared to commonly used biomarkers including complete blood counts and C-reactive protein. Conclusions. Although the body of evidence is limited, initial observations suggest that procalcitonin can be used in pediatric trauma and burn patients as both a prognostic and a diagnostic marker, aiding in the identification of infection in patients with extensive underlying inflammation. PMID:27355024

Sensitivity and Specificity of Polysomnographic Criteria for Defining Insomnia

PubMed Central

Edinger, Jack D.; Ulmer, Christi S.; Means, Melanie K.

2013-01-01

Study Objectives: In recent years, polysomnography-based eligibility criteria have been increasingly used to identify candidates for insomnia research, and this has been particularly true of studies evaluating pharmacologic therapy for primary insomnia. However, the sensitivity and specificity of PSG for identifying individuals with insomnia is unknown, and there is no consensus on the criteria sets which should be used for participant selection. In the current study, an archival data set was used to test the sensitivity and specificity of PSG measures for identifying individuals with primary insomnia in both home and lab settings. We then evaluated the sensitivity and specificity of the eligibility criteria employed in a number of recent insomnia trials for identifying primary insomnia sufferers in our sample. Design: Archival data analysis. Settings: Study participants' homes and a clinical sleep laboratory. Participants: Adults: 76 with primary insomnia and 78 non-complaining normal sleepers. Measurements and Results: ROC and cross-tabs analyses were used to evaluate the sensitivity and specificity of PSG-derived total sleep time, latency to persistent sleep, wake after sleep onset, and sleep efficiency for discriminating adults with primary insomnia from normal sleepers. None of the individual criteria accurately discriminated PI from normal sleepers, and none of the criteria sets used in recent trials demonstrated acceptable sensitivity and specificity for identifying primary insomnia. Conclusions: The use of quantitative PSG-based selection criteria in insomnia research may exclude many who meet current diagnostic criteria for an insomnia disorder. Citation: Edinger JD; Ulmer CS; Means MK. Sensitivity and specificity of polysomnographic criteria for defining insomnia. J Clin Sleep Med 2013;9(5):481-491. PMID:23674940

Financial strain and birth weight: the mediating role of psychological distress.

PubMed

Mitchell, Amanda M; Christian, Lisa M

2017-02-01

The effects of financial strain during pregnancy have received limited attention. In addition, data examining the pathways by which SES indicators contribute to birth weight are lacking. The objective of the current study was to examine the potential pathway of psychological distress in the relationship between financial strain and birth weight. Participants consisted of 138 pregnant women who completed measures assessing financial strain, depressive symptoms, pregnancy-specific distress, perceived stress, and general anxiety during pregnancy (mean gestational age = 18.5, SD = 7.2). Birth outcome data were obtained via medical record review. Simple and parallel mediation models were conducted using PROCESS. Simple mediation models showed that depressive symptoms (95% CI -24.65, -0.90) and pregnancy-specific distress (95% CI -37.31, -5.91), but not perceived stress (95% CI -31.17, 4.69) or anxiety (95% CI -25.84, 5.57), served as mediators in the relationship between financial strain and birth weight. When depressive symptoms and pregnancy-specific distress were included in the same mediation model, only pregnancy-specific distress remained significant. Financial strain was positively associated with all facets of psychological distress and negatively associated with birth weight during pregnancy. The current study demonstrated the mechanistic role of pregnancy-specific distress in the link between financial strain and birth weight in a racially diverse sample. Interventions targeting pregnancy-specific distress may mitigate the effects of financial strain on birth weight. Studies examining whether pregnancy-specific distress accounts for the relationship between other types of stressor exposures and birth weight would be informative.

2D Affine and Projective Shape Analysis.

PubMed

Bryner, Darshan; Klassen, Eric; Huiling Le; Srivastava, Anuj

2014-05-01

Current techniques for shape analysis tend to seek invariance to similarity transformations (rotation, translation, and scale), but certain imaging situations require invariance to larger groups, such as affine or projective groups. Here we present a general Riemannian framework for shape analysis of planar objects where metrics and related quantities are invariant to affine and projective groups. Highlighting two possibilities for representing object boundaries-ordered points (or landmarks) and parameterized curves-we study different combinations of these representations (points and curves) and transformations (affine and projective). Specifically, we provide solutions to three out of four situations and develop algorithms for computing geodesics and intrinsic sample statistics, leading up to Gaussian-type statistical models, and classifying test shapes using such models learned from training data. In the case of parameterized curves, we also achieve the desired goal of invariance to re-parameterizations. The geodesics are constructed by particularizing the path-straightening algorithm to geometries of current manifolds and are used, in turn, to compute shape statistics and Gaussian-type shape models. We demonstrate these ideas using a number of examples from shape and activity recognition.

Making the Implicit Explicit: Towards an Assurance Case for DO-178C

NASA Technical Reports Server (NTRS)

Holloway, C. Michael

2013-01-01

For about two decades, compliance with Software Considerations in Airborne Systems and Equipment Certification (DO-178B) has been the primary means for receiving regulatory approval for using software on commercial airplanes. A new edition of the standard, DO-178C, was published in December 2011, and regulatory bodies have started the process towards recognizing this edition. The stated purpose of DO-178C remains unchanged from its predecessor: providing guidance “for the production of software for airborne systems and equipment that performs its intended function with a level of confidence in safety that complies with airworthiness requirements.” Within the text of the guidance, little or no rationale is given for how a particular objective or collection of objectives contributes to achieving this purpose. Thus the assurance case for the document is implicit. This paper discusses a current effort to make the implicit explicit. In particular, the paper describes the current status of the research seeking to identify the specific arguments contained in, or implied by, the DO-178C guidance that implicitly justify the assumption that the document meets its stated purpose.

Diagnosis of asthma: diagnostic testing.

PubMed

Brigham, Emily P; West, Natalie E

2015-09-01

Asthma is a heterogeneous disease, encompassing both atopic and non-atopic phenotypes. Diagnosis of asthma is based on the combined presence of typical symptoms and objective tests of lung function. Objective diagnostic testing consists of 2 components: (1) demonstration of airway obstruction, and (2) documentation of variability in degree of obstruction. A review of current guidelines and literature was performed regarding diagnostic testing for asthma. Spirometry with bronchodilator reversibility testing remains the mainstay of asthma diagnostic testing for children and adults. Repetition of the test over several time points may be necessary to confirm airway obstruction and variability thereof. Repeated peak flow measurement is relatively simple to implement in a clinical and home setting. Bronchial challenge testing is reserved for patients in whom the aforementioned testing has been unrevealing but clinical suspicion remains, though is associated with low specificity. Demonstration of eosinophilic inflammation, via fractional exhaled nitric oxide measurement, or atopy, may be supportive of atopic asthma, though diagnostic utility is limited particularly in nonatopic asthma. All efforts should be made to confirm the diagnosis of asthma in those who are being presumptively treated but have not had objective measurements of variability in the degree of obstruction. Multiple testing modalities are available for objective confirmation of airway obstruction and variability thereof, consistent with a diagnosis of asthma in the appropriate clinical context. Providers should be aware that both these characteristics may be present in other disease states, and may not be specific to a diagnosis of asthma. © 2015 ARS-AAOA, LLC.

Research Needs in Fire Safety for the Human Exploration and Utilization of Space: Proceedings and Research Plan

NASA Technical Reports Server (NTRS)

Ruff, Gary A.

2003-01-01

The purpose of the workshop documented in this publication was to bring together personnel responsible for the design and operations of the International Space Station (ISS) and the fire protection research community to review the current knowledge in fire safety relative to spacecraft. From this review, research needs were identified that were then used to formulate a research plan with specific objectives. In this document, I have attempted to capture the very informative and lively discussions that occurred in the plenary sessions and the working groups. I hope that it will be useful to readers and serve as a significant step in assuring fire protection for the crews of current and future spacecraft.

Current Challenges for HTCMC Aero-Propulsion Components

NASA Technical Reports Server (NTRS)

DiCarlo, James A.; Bansal, Narottam P.

2007-01-01

In comparison to the best metallic materials, HTCMC aero-propulsion engine components offer the opportunity of reduced weight and higher temperature operation, with corresponding improvements in engine cooling requirements, emissions, thrust, and specific fuel consumption. Although much progress has been made in the development of advanced HTCMC constituent materials and processes, major challenges still remain for their implementation into these components. The objectives of this presentation are to briefly review (1) potential HTCMC aero-propulsion components and their generic material performance requirements, (2) recent progress at NASA and elsewhere concerning advanced constituents and processes for meeting these requirements, (3) key HTCMC component implementation challenges that are currently being encountered, and (4) on-going activities within the new NASA Fundamental Aeronautics Program that are addressing these challenges.

A Niche-Based Framework to Assess Current Monitoring of European Forest Birds and Guide Indicator Species' Selection

PubMed Central

Wade, Amy S. I.; Barov, Boris; Burfield, Ian J.; Gregory, Richard D.; Norris, Ken; Vorisek, Petr; Wu, Taoyang; Butler, Simon J.

2014-01-01

Concern that European forest biodiversity is depleted and declining has provoked widespread efforts to improve management practices. To gauge the success of these actions, appropriate monitoring of forest ecosystems is paramount. Multi-species indicators are frequently used to assess the state of biodiversity and its response to implemented management, but generally applicable and objective methodologies for species' selection are lacking. Here we use a niche-based approach, underpinned by coarse quantification of species' resource use, to objectively select species for inclusion in a pan-European forest bird indicator. We identify both the minimum number of species required to deliver full resource coverage and the most sensitive species' combination, and explore the trade-off between two key characteristics, sensitivity and redundancy, associated with indicators comprising different numbers of species. We compare our indicator to an existing forest bird indicator selected on the basis of expert opinion and show it is more representative of the wider community. We also present alternative indicators for regional and forest type specific monitoring and show that species' choice can have a significant impact on the indicator and consequent projections about the state of the biodiversity it represents. Furthermore, by comparing indicator sets drawn from currently monitored species and the full forest bird community, we identify gaps in the coverage of the current monitoring scheme. We believe that adopting this niche-based framework for species' selection supports the objective development of multi-species indicators and that it has good potential to be extended to a range of habitats and taxa. PMID:24819734

General object recognition is specific: Evidence from novel and familiar objects.

PubMed

Richler, Jennifer J; Wilmer, Jeremy B; Gauthier, Isabel

2017-09-01

In tests of object recognition, individual differences typically correlate modestly but nontrivially across familiar categories (e.g. cars, faces, shoes, birds, mushrooms). In theory, these correlations could reflect either global, non-specific mechanisms, such as general intelligence (IQ), or more specific mechanisms. Here, we introduce two separate methods for effectively capturing category-general performance variation, one that uses novel objects and one that uses familiar objects. In each case, we show that category-general performance variance is unrelated to IQ, thereby implicating more specific mechanisms. The first approach examines three newly developed novel object memory tests (NOMTs). We predicted that NOMTs would exhibit more shared, category-general variance than familiar object memory tests (FOMTs) because novel objects, unlike familiar objects, lack category-specific environmental influences (e.g. exposure to car magazines or botany classes). This prediction held, and remarkably, virtually none of the substantial shared variance among NOMTs was explained by IQ. Also, while NOMTs correlated nontrivially with two FOMTs (faces, cars), these correlations were smaller than among NOMTs and no larger than between the face and car tests themselves, suggesting that the category-general variance captured by NOMTs is specific not only relative to IQ, but also, to some degree, relative to both face and car recognition. The second approach averaged performance across multiple FOMTs, which we predicted would increase category-general variance by averaging out category-specific factors. This prediction held, and as with NOMTs, virtually none of the shared variance among FOMTs was explained by IQ. Overall, these results support the existence of object recognition mechanisms that, though category-general, are specific relative to IQ and substantially separable from face and car recognition. They also add sensitive, well-normed NOMTs to the tools available to study object recognition. Copyright © 2017 Elsevier B.V. All rights reserved.

Serial dependence promotes object stability during occlusion

PubMed Central

Liberman, Alina; Zhang, Kathy; Whitney, David

2016-01-01

Object identities somehow appear stable and continuous over time despite eye movements, disruptions in visibility, and constantly changing visual input. Recent results have demonstrated that the perception of orientation, numerosity, and facial identity is systematically biased (i.e., pulled) toward visual input from the recent past. The spatial region over which current orientations or face identities are pulled by previous orientations or identities, respectively, is known as the continuity field, which is temporally tuned over the past several seconds (Fischer & Whitney, 2014). This perceptual pull could contribute to the visual stability of objects over short time periods, but does it also address how perceptual stability occurs during visual discontinuities? Here, we tested whether the continuity field helps maintain perceived object identity during occlusion. Specifically, we found that the perception of an oriented Gabor that emerged from behind an occluder was significantly pulled toward the random (and unrelated) orientation of the Gabor that was seen entering the occluder. Importantly, this serial dependence was stronger for predictable, continuously moving trajectories, compared to unpredictable ones or static displacements. This result suggests that our visual system takes advantage of expectations about a stable world, helping to maintain perceived object continuity despite interrupted visibility. PMID:28006066

Does semantic preactivation reduce inattentional blindness?

PubMed

Kreitz, Carina; Schnuerch, Robert; Furley, Philip A; Gibbons, Henning; Memmert, Daniel

2015-04-01

We are susceptible to failures of awareness if a stimulus occurs unexpectedly and our attention is focused elsewhere. Such inattentional blindness is modulated by various parameters, including stimulus attributes, the observer's cognitive resources, and the observer's attentional set regarding the primary task. In three behavioral experiments with a total of 360 participants, we investigated whether mere semantic preactivation of the color of an unexpected object can reduce inattentional blindness. Neither explicitly mentioning the color several times before the occurrence of the unexpected stimulus nor priming the color more implicitly via color-related concepts could significantly reduce the susceptibility to inattentional blindness. Even putting the specific color concept in the main focus of the primary task did not lead to reduced inattentional blindness. Thus, we have shown that the failure to consciously perceive unexpected objects was not moderated by semantic preactivation of the objects' most prominent feature: its color. We suggest that this finding reflects the rather general principle that preactivations that are not motivationally relevant for one's current selection goals do not suffice to make an unexpected object overcome the threshold of awareness.

Optimisation of flight dynamic control based on many-objectives meta-heuristic: a comparative study

NASA Astrophysics Data System (ADS)

Bureerat, Sujin; Pholdee, Nantiwat; Radpukdee, Thana

2018-05-01

Development of many objective meta-heuristics (MnMHs) is a currently interesting topic as they are suitable to real applications of optimisation problems which usually require many ob-jectives. However, most of MnMHs have been mostly developed and tested based on stand-ard testing functions while the use of MnMHs to real applications is rare. Therefore, in this work, MnMHs are applied for optimisation design of flight dynamic control. The design prob-lem is posed to find control gains for minimising; the control effort, the spiral root, the damp-ing in roll root, sideslip angle deviation, and maximising; the damping ratio of the dutch-roll complex pair, the dutch-roll frequency, bank angle at pre-specified times 1 seconds and 2.8 second subjected to several constraints based on Military Specifications (1969) requirement. Several established many-objective meta-heuristics (MnMHs) are used to solve the problem while their performances are compared. With this research work, performance of several MnMHs for flight control is investigated. The results obtained will be the baseline for future development of flight dynamic and control.

Girls in detail, boys in shape: gender differences when drawing cubes in depth.

PubMed

Lange-Küttner, C; Ebersbach, M

2013-08-01

The current study tested gender differences in the developmental transition from drawing cubes in two- versus three dimensions (3D), and investigated the underlying spatial abilities. Six- to nine-year-old children (N = 97) drew two occluding model cubes and solved several other spatial tasks. Girls more often unfolded the various sides of the cubes into a layout, also called diagrammatic cube drawing (object design detail). In girls, the best predictor for drawing the cubes was Mental Rotation Test (MRT) accuracy. In contrast, boys were more likely to preserve the optical appearance of the cube array. Their drawing in 3D was best predicted by MRT reaction time and the Embedded Figures Test (EFT). This confirmed boys' stronger focus on the contours of an object silhouette (object shape). It is discussed whether the two gender-specific approaches to drawing in three dimensions reflect two sides of the appearance-reality distinction in drawing, that is graphic syntax of object design features versus visual perception of projective space. © 2012 The British Psychological Society.

Toward a whole-landscape approach for sustainable land use in the tropics.

PubMed

DeFries, R; Rosenzweig, C

2010-11-16

Increasing food production and mitigating climate change are two primary but seemingly contradictory objectives for tropical landscapes. This special feature examines synergies and trade-offs among these objectives. Four themes emerge from the papers: the important roles of both forest and agriculture sectors for climate mitigation in tropical countries; the minor contribution from deforestation-related agricultural expansion to overall food production at global and continental scales; the opportunities for synergies between improved food production and reductions in greenhouse gas emissions through diversion of agricultural expansion to already-cleared lands, improved soil, crop, and livestock management, and agroforestry; and the need for targeted policy and management interventions to make these synergistic opportunities a reality. We conclude that agricultural intensification is a key factor to meet dual objectives of food production and climate mitigation, but there is no single panacea for balancing these objectives in all tropical landscapes. Place-specific strategies for sustainable land use emerge from assessments of current land use, demographics, and other biophysical and socioeconomic characteristics, using a whole-landscape, multisector perspective.

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting.

PubMed

Palmer, Brian C; DeLouise, Lisa A

2016-12-15

Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases.

Criminal history systems: new technology and new directions

NASA Astrophysics Data System (ADS)

Threatte, James

1997-02-01

Many forces are driving states to improve their current Criminal History and On-Line Criminal Justice Information Systems. The predominate factors compelling this movement are (1) the deterioration and cost of supporting older legacy systems, (2) current generation high performance, low cost hardware and system software, and (3) funding programs, such as the National Criminal History Improvement Program, which are targeted specifically at improving these important systems. In early 1996, SAIC established an Internal Research and Development project devoted to Computerized Criminal History Systems (CCH). This project began with an assessment of current hardware, operating system, and relational database technology. Application software design and development approaches were then reviewed with a focus on object-oriented approaches, three tier client server architectures, and tools that enable the `right sizing' of systems. An operational prototype of a State CCH system was established based on the results of these investigations.

Nanoparticle enabled transdermal drug delivery systems for enhanced dose control and tissue targeting

PubMed Central

Palmer, Brian C.; DeLouise, Lisa A.

2017-01-01

Transdermal drug delivery systems have been around for decades, and current technologies (e.g. patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses. The objective of current transdermal drug delivery research is to discover ways to enhance skin penetration of larger, hydrophilic drugs and macromolecules for disease treatment and vaccination. Nanocarriers made of lipids, metals, or polymers have been successfully used to increase penetration of drugs or vaccines, control drug release, and target drugs to specific areas of skin in vivo. While more research is needed to identify the safety of nanocarriers, this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics. Here, we review the current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases. PMID:27983701

NASA / Pratt and Whitney Collaborative Partnership Research in Ultra High Bypass Cycle Propulsion Concepts

NASA Technical Reports Server (NTRS)

Hughes, Chris; Lord, Wed

2008-01-01

Current collaborative research with Pratt & Whitney on Ultra High Bypass Engine Cycle noise, performance and emissions improvements as part of the Subsonic Fixed Wing Project Ultra High Bypass Engine Partnership Element is discussed. The Subsonic Fixed Wing Project goals are reviewed, as well as their relative technology level compared to previous NASA noise program goals. Progress toward achieving the Subsonic Fixed Wing Project goals over the 2008 fiscal year by the UHB Partnership in this area of research are reviewed. The current research activity in Ultra High Bypass Engine Cycle technology, specifically the Pratt & Whitney Geared Turbofan, at NASA and Pratt & Whitney are discussed including the contributions each entity bring toward the research project, and technical plans and objectives. Pratt & Whitney Geared Turbofan current and future technology and business plans are also discussed, including the role the NASA SFW UHB partnership plays toward achieving those goals.

Identification of liver cancer-specific aptamers using whole live cells.

PubMed

Shangguan, Dihua; Meng, Ling; Cao, Zehui Charles; Xiao, Zeyu; Fang, Xiaohong; Li, Ying; Cardona, Diana; Witek, Rafal P; Liu, Chen; Tan, Weihong

2008-02-01

Liver cancer is the third most deadly cancers in the world. Unfortunately, there is no effective treatment. One of the major problems is that most cancers are diagnosed in the later stage, when surgical resection is not feasible. Thus, accurate early diagnosis would significantly improve the clinical outcome of liver cancer. Currently, there are no effective molecular probes to recognize biomarkers that are specific for liver cancer. The objective of our current study is to identify liver cancer cell-specific molecular probes that could be used for liver cancer recognition and diagnosis. We applied a newly developed cell-SELEX (Systematic Evolution of Ligands by EXponential enrichment) method for the generation of molecular probes for specific recognition of liver cancer cells. The cell-SELEX uses whole live cells as targets to select aptamers (designed DNA/RNA) for cell recognition. In generating aptamers for liver cancer recognition, two liver cell lines were used: a liver cancer cell line BNL 1ME A.7R.1 (MEAR) and a noncancer cell line, BNL CL.2 (BNL). Both cell lines were originally derived from Balb/cJ mice. Through multiple rounds of selection using BNL as a control, we have identified a panel of aptamers that specifically recognize the cancer cell line MEAR with Kd in the nanomolar range. We have also demonstrated that some of the selective aptamers could specifically bind liver cancer cells in a mouse model. There are two major new results (compared with our reported cell-SELEX methodology) in addition to the generation of aptamers specifically for liver cancer. The first one is that our current study demonstrates that cell-based aptamer selection can select specific aptamers for multiple cell lines, even for two cell lines with minor differences (MEAR cell is derived from BNL by chemical inducement); and the second result is that cell-SELEX can be used for adhesive cells and thus open the door for solid tumor selection and investigation. The newly generated cancer-specific aptamers hold great promise as molecular probes for cancer early diagnosis and basic mechanism studies.

Advanced Software Development Workstation Project

NASA Technical Reports Server (NTRS)

Lee, Daniel

1989-01-01

The Advanced Software Development Workstation Project, funded by Johnson Space Center, is investigating knowledge-based techniques for software reuse in NASA software development projects. Two prototypes have been demonstrated and a third is now in development. The approach is to build a foundation that provides passive reuse support, add a layer that uses domain-independent programming knowledge, add a layer that supports the acquisition of domain-specific programming knowledge to provide active support, and enhance maintainability and modifiability through an object-oriented approach. The development of new application software would use specification-by-reformulation, based on a cognitive theory of retrieval from very long-term memory in humans, and using an Ada code library and an object base. Current tasks include enhancements to the knowledge representation of Ada packages and abstract data types, extensions to support Ada package instantiation knowledge acquisition, integration with Ada compilers and relational databases, enhancements to the graphical user interface, and demonstration of the system with a NASA contractor-developed trajectory simulation package. Future work will focus on investigating issues involving scale-up and integration.

Sampling Approaches for Multi-Domain Internet Performance Measurement Infrastructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calyam, Prasad

2014-09-15

The next-generation of high-performance networks being developed in DOE communities are critical for supporting current and emerging data-intensive science applications. The goal of this project is to investigate multi-domain network status sampling techniques and tools to measure/analyze performance, and thereby provide “network awareness” to end-users and network operators in DOE communities. We leverage the infrastructure and datasets available through perfSONAR, which is a multi-domain measurement framework that has been widely deployed in high-performance computing and networking communities; the DOE community is a core developer and the largest adopter of perfSONAR. Our investigations include development of semantic scheduling algorithms, measurement federationmore » policies, and tools to sample multi-domain and multi-layer network status within perfSONAR deployments. We validate our algorithms and policies with end-to-end measurement analysis tools for various monitoring objectives such as network weather forecasting, anomaly detection, and fault-diagnosis. In addition, we develop a multi-domain architecture for an enterprise-specific perfSONAR deployment that can implement monitoring-objective based sampling and that adheres to any domain-specific measurement policies.« less

Specific phobias.

PubMed

Hamm, Alfons O

2009-09-01

Exposure based treatments in which patients are systematically confronted with their feared objects of situations are highly effective in the treatment of specific phobias and produce stable improvement both in reported fear and behavioral avoidance. Exposure in reality is more effective in most cases than exposure in sensu. For situations that are difficult to realize, exposure in virtual environments has become increasingly valuable. Exposure in vivo is clearly superior to pharmacotherapy, although cognitive enhancers have been successfully used recently to increase the effect of exposure therapy. The induction of relaxation is not a necessary precondition for exposure therapy. Rather the current mechanisms of change focus on extinction learning as being the central mechanism both on a cognitive level namely that the feared object is no longer associated with severely threatening consequence but also on an affective level, meaning that feared cue is no longer capable to activate the fear circuit in the brain. Accordingly future diagnostic categorizations of phobic disorders in the DSM-V should rather focus on the pattern of the fear response that needs to be changed than on the eliciting cues or situations that are avoided.

Successful industry-university graduate-level research partnerships at the Pennsylvania State University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feltus, M.A.

1996-12-31

Previously, nuclear utilities have been considered {open_quotes}deep pockets{close_quotes} for university research; however, in the current cost-cutting competitive environment, most utilities have drastically reduced or eliminated research. Any collaboration with universities requires that any research effort have a focused objective, short-term duration, and tangible payback. Furthermore, the research must concentrate on solving operating problems, rather than on long-term general concerns. Although practical studies may seem mundane, untheoretical, and uninteresting for most academics, such pragmatic topics can provide interesting research for students and helpful results for the utilities. This paper provides examples of the author`s research funded by utilities. Each project hasmore » a specific objective involving a particular utility need or computer code analysis tool.« less

Technology Transfer and the Civil Space Program. Volume 2: Workshop proceedings

NASA Technical Reports Server (NTRS)

1992-01-01

The objectives were to (1) provide a top-level review of the Integrated Technology Plan (ITP) and current civil space technology plans, including planning processes and technologies; (2) discuss and assess technology transfer (TT) experiences across a wide range of participants; (3) identify alternate categories/strategies for TT and define the objectives of transfer processes in each case; (4) identify the roles of various government 'stakeholders', aerospace industry, industries at large, and universities in civil space technology research, development, demonstration, and transfer; (5) identify potential barriers and/or opportunities to successful civil space TT; (6) identify specific needs for innovations in policy, programs, and/or procedures to facilitate TT; and (7) develop a plan of attack for the development of a workshop report. Papers from the workshop are presented.

[Application of the balanced scorecard in nursing practice].

PubMed

Huang, Tsai-Yu; Chwo, Miao-Ju

2004-02-01

Kaplan and Norton's balanced scorecard (BSC) was developed in 1992. It was designed to be both a performance framework and a management methodology. The BSC enables an organization to convert its mission and vision into specific strategic objectives across four perspectives: (1) the financial perspective, (2) the customer perspective, (3) the internal business process perspective, and (4) the learning and growth perspective. Emphasis is focused on the balance of internal and external, outcome and future, and subjective and objective measures. Currently, some health care organizations have implemented the concept of the BSC as a performance measurement tool and are convinced that the BSC can be of great value to an organization. This paper provides development of the BSC and its application in the health care system and nursing practice.

Writing a Research Proposal to The Research Council of Oman.

PubMed

Al-Shukaili, Ahmed; Al-Maniri, Abdullah

2017-05-01

Writing a research proposal can be a challenging task for young researchers. This article explains how to write a strong research proposal to apply for funding, specifically, a proposal for The Research Council (TRC) of Oman. Three different research proposal application forms are currently used in TRC, including Open Research Grant (ORG), Graduate Research Support Program (GRSP), and Faculty-mentored Undergraduate Research Award Program (FURAP). The application forms are filled and submitted electronically on TRC website. Each of the proposals submitted to TRC is selected through a rigorous reviewing and screening process. Novelty and originality of the research idea is the most crucial element in writing a research proposal. Performing an in-depth review of the literature will assist you to compose a good researchable question and generate a strong hypothesis. The development of a good hypothesis will offer insight into the specific objectives of a study. Research objectives should be focused, measurable, and achievable by a specific time using the most appropriate methodology. Moreover, it is essential to select a proper study design in-line with the purpose of the study and the hypothesis. Furthermore, social/economic impact and reasonable budget of proposed research are important criteria in research proposal evaluation by TRC. Finally, ethical principles should be observed before writing a research proposal involving human or animal subjects.

Streamlining Metadata and Data Management for Evolving Digital Libraries

NASA Astrophysics Data System (ADS)

Clark, D.; Miller, S. P.; Peckman, U.; Smith, J.; Aerni, S.; Helly, J.; Sutton, D.; Chase, A.

2003-12-01

What began two years ago as an effort to stabilize the Scripps Institution of Oceanography (SIO) data archives from more than 700 cruises going back 50 years, has now become the operational fully-searchable "SIOExplorer" digital library, complete with thousands of historic photographs, images, maps, full text documents, binary data files, and 3D visualization experiences, totaling nearly 2 terabytes of digital content. Coping with data diversity and complexity has proven to be more challenging than dealing with large volumes of digital data. SIOExplorer has been built with scalability in mind, so that the addition of new data types and entire new collections may be accomplished with ease. It is a federated system, currently interoperating with three independent data-publishing authorities, each responsible for their own quality control, metadata specifications, and content selection. The IT architecture implemented at the San Diego Supercomputer Center (SDSC) streamlines the integration of additional projects in other disciplines with a suite of metadata management and collection building tools for "arbitrary digital objects." Metadata are automatically harvested from data files into domain-specific metadata blocks, and mapped into various specification standards as needed. Metadata can be browsed and objects can be viewed onscreen or downloaded for further analysis, with automatic proprietary-hold request management.

Quantitative Stratification of Diffuse Parenchymal Lung Diseases

PubMed Central

Raghunath, Sushravya; Rajagopalan, Srinivasan; Karwoski, Ronald A.; Maldonado, Fabien; Peikert, Tobias; Moua, Teng; Ryu, Jay H.; Bartholmai, Brian J.; Robb, Richard A.

2014-01-01

Diffuse parenchymal lung diseases (DPLDs) are characterized by widespread pathological changes within the pulmonary tissue that impair the elasticity and gas exchange properties of the lungs. Clinical-radiological diagnosis of these diseases remains challenging and their clinical course is characterized by variable disease progression. These challenges have hindered the introduction of robust objective biomarkers for patient-specific prediction based on specific phenotypes in clinical practice for patients with DPLD. Therefore, strategies facilitating individualized clinical management, staging and identification of specific phenotypes linked to clinical disease outcomes or therapeutic responses are urgently needed. A classification schema consistently reflecting the radiological, clinical (lung function and clinical outcomes) and pathological features of a disease represents a critical need in modern pulmonary medicine. Herein, we report a quantitative stratification paradigm to identify subsets of DPLD patients with characteristic radiologic patterns in an unsupervised manner and demonstrate significant correlation of these self-organized disease groups with clinically accepted surrogate endpoints. The proposed consistent and reproducible technique could potentially transform diagnostic staging, clinical management and prognostication of DPLD patients as well as facilitate patient selection for clinical trials beyond the ability of current radiological tools. In addition, the sequential quantitative stratification of the type and extent of parenchymal process may allow standardized and objective monitoring of disease, early assessment of treatment response and mortality prediction for DPLD patients. PMID:24676019

Current Concepts in Gastrointestinal Photodynamic Therapy

PubMed Central

Webber, John; Herman, Mark; Kessel, David; Fromm, David

1999-01-01

Objective To review current concepts of photodynamic therapy (PDT) applied to the treatment of tumors of the gastrointestinal tract. Summary Background Data PDT initially involves the uptake or production of a photosensitive compound by tumor cells. Subsequent activation of the photoreactive compound by a specific wavelength of light results in cell death, either directly or as a result of vascular compromise and/or apoptosis. Methods The authors selectively review current concepts relating to photosensitization, photoactivation, time of PDT application, tissue selectivity, sites of photodynamic action, PDT effects on normal tissue, limitations of PDT, toxicity of photosensitizers, application of principles of PDT to tumor detection, and current applications of PDT to tumors of the gastrointestinal tract. Results PDT is clearly effective for small cancers, but it is not yet clear in which cases such treatment is more effective than other currently acceptable approaches. The major side effect of PDT is cutaneous photosensitization. The major limitation of PDT is depth of tumor kill. As data from current and future clinical trials become available, a clearer perspective of where PDT fits in the treatment of cancers will be gained. Many issues regarding pharmacokinetic data of photosensitizers, newer technology involved in light sources, optimal treatment regimens that take advantage of the pharmacophysiology of photoablation, and light dosimetry still require solution. One can foresee application of differing sensitizers and light sources depending on the specific clinical situation. As technologic advances occur, interstitial PDT may have significant application. Conclusions PDT has a potentially important role either as a primary or adjuvant mode of treatment of tumors of the gastrointestinal tract. PMID:10400031

Fourier transform magnetic resonance current density imaging (FT-MRCDI) from one component of magnetic flux density.

PubMed

Ider, Yusuf Ziya; Birgul, Ozlem; Oran, Omer Faruk; Arikan, Orhan; Hamamura, Mark J; Muftuler, L Tugan

2010-06-07

Fourier transform (FT)-based algorithms for magnetic resonance current density imaging (MRCDI) from one component of magnetic flux density have been developed for 2D and 3D problems. For 2D problems, where current is confined to the xy-plane and z-component of the magnetic flux density is measured also on the xy-plane inside the object, an iterative FT-MRCDI algorithm is developed by which both the current distribution inside the object and the z-component of the magnetic flux density on the xy-plane outside the object are reconstructed. The method is applied to simulated as well as actual data from phantoms. The effect of measurement error on the spatial resolution of the current density reconstruction is also investigated. For 3D objects an iterative FT-based algorithm is developed whereby the projected current is reconstructed on any slice using as data the Laplacian of the z-component of magnetic flux density measured for that slice. In an injected current MRCDI scenario, the current is not divergence free on the boundary of the object. The method developed in this study also handles this situation.

Experience moderates overlap between object and face recognition, suggesting a common ability

PubMed Central

Gauthier, Isabel; McGugin, Rankin W.; Richler, Jennifer J.; Herzmann, Grit; Speegle, Magen; Van Gulick, Ana E.

2014-01-01

Some research finds that face recognition is largely independent from the recognition of other objects; a specialized and innate ability to recognize faces could therefore have little or nothing to do with our ability to recognize objects. We propose a new framework in which recognition performance for any category is the product of domain-general ability and category-specific experience. In Experiment 1, we show that the overlap between face and object recognition depends on experience with objects. In 256 subjects we measured face recognition, object recognition for eight categories, and self-reported experience with these categories. Experience predicted neither face recognition nor object recognition but moderated their relationship: Face recognition performance is increasingly similar to object recognition performance with increasing object experience. If a subject has a lot of experience with objects and is found to perform poorly, they also prove to have a low ability with faces. In a follow-up survey, we explored the dimensions of experience with objects that may have contributed to self-reported experience in Experiment 1. Different dimensions of experience appear to be more salient for different categories, with general self-reports of expertise reflecting judgments of verbal knowledge about a category more than judgments of visual performance. The complexity of experience and current limitations in its measurement support the importance of aggregating across multiple categories. Our findings imply that both face and object recognition are supported by a common, domain-general ability expressed through experience with a category and best measured when accounting for experience. PMID:24993021

Experience moderates overlap between object and face recognition, suggesting a common ability.

PubMed

Gauthier, Isabel; McGugin, Rankin W; Richler, Jennifer J; Herzmann, Grit; Speegle, Magen; Van Gulick, Ana E

2014-07-03

Some research finds that face recognition is largely independent from the recognition of other objects; a specialized and innate ability to recognize faces could therefore have little or nothing to do with our ability to recognize objects. We propose a new framework in which recognition performance for any category is the product of domain-general ability and category-specific experience. In Experiment 1, we show that the overlap between face and object recognition depends on experience with objects. In 256 subjects we measured face recognition, object recognition for eight categories, and self-reported experience with these categories. Experience predicted neither face recognition nor object recognition but moderated their relationship: Face recognition performance is increasingly similar to object recognition performance with increasing object experience. If a subject has a lot of experience with objects and is found to perform poorly, they also prove to have a low ability with faces. In a follow-up survey, we explored the dimensions of experience with objects that may have contributed to self-reported experience in Experiment 1. Different dimensions of experience appear to be more salient for different categories, with general self-reports of expertise reflecting judgments of verbal knowledge about a category more than judgments of visual performance. The complexity of experience and current limitations in its measurement support the importance of aggregating across multiple categories. Our findings imply that both face and object recognition are supported by a common, domain-general ability expressed through experience with a category and best measured when accounting for experience. © 2014 ARVO.

Cutaneous T cell lymphoma: Current practices in blood assessment and the utility of T-cell receptor Vβ chain restriction

PubMed Central

Gibson, Juliet F; Huang, Jing; Liu, Kristina J; Carlson, Kacie R; Foss, Francine; Choi, Jaehyuk; Edelson, Richard; Hussong, Jerry W.; Mohl, Ramsey; Hill, Sally; Girardi, Sally

2016-01-01

Background Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T cell lymphoma (CTCL) is important for early detection, prognosis, and monitoring disease burden. Objective Determine the spectrum of current clinical practices; critically evaluate elements of current ISCL B1 and B2 staging criteria; and assess the potential role of TCR-Vβ analysis by flow cytometry. Methods We assessed current clinical practices by survey, and performed a retrospective analysis of 161 patients evaluated at Yale (2011-2014) to compare the sensitivity, specificity, PPV, and NPV of parameters for ISCL B2 staging. Results There was heterogeneity in clinical practices among institutions. ISCL B1 criteria did not capture five Yale cohort patients with immunophenotypic abnormalities who later progressed. TCR-Vβ testing was more specific than PCR and aided diagnosis in detecting clonality, but was of limited benefit in quantification of tumor burden. Limitations Because of limited follow-up involving a single center, further investigation will be necessary to conclude whether our proposed diagnostic algorithm is of general clinical benefit. Conclusion We propose further study of “modified B1 criteria”: CD4/CD8 ratio ≥5, %CD4+/CD26- ≥ 20%, %CD4+/CD7- ≥ 20%, with evidence of clonality. TCR-Vβ testing should be considered in future diagnostic and staging algorithms. PMID:26874819

Comparison of current ATDs with Chinese adults in anthropometry.

PubMed

Cao, Libo; Zhang, Kai; Lv, Xin; Yan, Lingbo

2016-05-18

Crash test dummies are full-scale anthropomorphic test devices (ATDs) that simulate the dimensions, weight proportions, and articulation of the human body and are used to measure human injury potential in vehicle crashes. The Hybrid III dummy family, which is widely used currently, takes selected percentiles of anthropometry dimensions of U.S. adults as design references. The objective of this study was to assess the difference in anthropometry between Chinese adults and the currently used dummy. Based on the Chinese National Physical Fitness Surveillance of the year 2000, 2005, 2010 and National Standard of China GB/T 10000-1988, a series of anthropometric parameters for Chinese adults were obtained, and data analysis was conducted between Chinese adults and ATDs that are currently used. The comparison revealed distinct anthropometric difference between ATDs and Chinese adults. Based on the latest data, median Chinese females were about 2.6% lower in stature and about 8.03% lower in body weight than the ATD design targets. Similarly, median Chinese males were about 3.48% shorter and weighed 11.89% less than the ATD design targets. Although the anthropometric differences between Chinese adults and the Hybrid III ATD specifications were modest and growing smaller, it is advisable to take the differences in anthropometry between ATDs and Chinese adults into consideration when developing new vehicles in China to provide effective protection specifically for Chinese occupants.

Structured decision making for managing pneumonia epizootics in bighorn sheep

USGS Publications Warehouse

Sells, Sarah N.; Mitchell, Michael S.; Edwards, Victoria L.; Gude, Justin A.; Anderson, Neil J.

2016-01-01

Good decision-making is essential to conserving wildlife populations. Although there may be multiple ways to address a problem, perfect solutions rarely exist. Managers are therefore tasked with identifying decisions that will best achieve desired outcomes. Structured decision making (SDM) is a method of decision analysis used to identify the most effective, efficient, and realistic decisions while accounting for values and priorities of the decision maker. The stepwise process includes identifying the management problem, defining objectives for solving the problem, developing alternative approaches to achieve the objectives, and formally evaluating which alternative is most likely to accomplish the objectives. The SDM process can be more effective than informal decision-making because it provides a transparent way to quantitatively evaluate decisions for addressing multiple management objectives while incorporating science, uncertainty, and risk tolerance. To illustrate the application of this process to a management need, we present an SDM-based decision tool developed to identify optimal decisions for proactively managing risk of pneumonia epizootics in bighorn sheep (Ovis canadensis) in Montana. Pneumonia epizootics are a major challenge for managers due to long-term impacts to herds, epistemic uncertainty in timing and location of future epizootics, and consequent difficulty knowing how or when to manage risk. The decision tool facilitates analysis of alternative decisions for how to manage herds based on predictions from a risk model, herd-specific objectives, and predicted costs and benefits of each alternative. Decision analyses for 2 example herds revealed that meeting management objectives necessitates specific approaches unique to each herd. The analyses showed how and under what circumstances the alternatives are optimal compared to other approaches and current management. Managers can be confident that these decisions are effective, efficient, and realistic because they explicitly account for important considerations managers implicitly weigh when making decisions, including competing management objectives, uncertainty in potential outcomes, and risk tolerance.

Influence of the Yukon River on the Bering Sea

NASA Technical Reports Server (NTRS)

Dean, K.; Mcroy, C. P.

1986-01-01

The relationships between the discharge of the Yukon River to the currents and biological productivity in the northern Bering Sea were studied. Specific objectives were: to develop thermal, sediment, and chlorophyll surface maps using Thematic Mapper (TM) data of the discharge of the Yukon River and the Alaskan Coastal Current during the ice free season; to develop a historical model of the distribution of the Yukon River discharge and the Alaskan Coastal Current using LANDSAT Multispectral band scanner (MSS) and NOAA satellite imagery; and to use high resolution TM data to define the surface dynamics of the front between the Alaskan Coastal Current and the Bering Shelf/Anadyr Current. LANDSAT MSS, TM, and Advanced Very High Resolution Radiometer (AVHRR) data were recorded during the 1985 ice free period. The data coincided with shipboard measurements acquired by Inner Shelf Transfer and Recycling (ISTAR) project scientists. An integrated model of the distribution of turbid water discharged from the Yukon River was compiled. A similar model is also being compiled for the Alaskan Coastal and Bering Shelf/Anadyr water masses based on their thermal expressions seen on AVHRR imagery.

E-cigarette use among Serbian adults: prevalence and user characteristics.

PubMed

Kilibarda, Biljana; Mravcik, Viktor; Martens, Marcus Sebastian

2016-03-01

The objective was to report the prevalence and characteristics of electronic cigarette (e-cigarette) users in order to inform an appropriate response to this emerging challenge in tobacco control. Data were drawn from a cross-sectional survey conducted in 2014 that used computer-assisted interviewing in a representative sample of 5385 Serbian adults age 18-64 years. Lifetime e-cigarette use and current use was reported by 9.6 and 2 % of adults, respectively. Younger adults had a higher prevalence of both lifetime and current use. Females were more likely to be current e-cigarette users than males. The majority of ever and current e-cigarette users were current or past cigarette smokers, but lifetime use was reported by non-smokers as well. Electronic cigarettes are popular in Serbia; one in ten adults had tried them at least once. Because females and young adults were more likely to use e-cigarettes, a targeted response in these specific groups is needed. A standardised methodology for monitoring e-cigarette use should be established and surveys exploring motives for and attitudes towards e-cigarettes use should be conducted.

Influence of the Yukon River on the Bering Sea

NASA Technical Reports Server (NTRS)

Dean, K.; Mcroy, C. P.

1986-01-01

The purpose is to use satellite data to study relationships between discharge of the Yukon River to currents and biologic productivity in the northern Bering Sea. Amended specific objectives are: to develop thermal, sediment and chlorophyll surface maps using thematic mapping (TM) data of the discharge of the Yukon River and the Alaska Coastal Current during the ice free season; to develop a historical model of the distribution of the Yukon River discharge and the Alaska Coastal Current using LANDSAT multispectral scanner (MMS) and NOAA satellite imagery; and to use high resolution TM data to define the surface dynamics of the front between the Alaska Coastal Current and the Bering Shelf/Anadyr Current. LANDSAT MSS and TM, and Advanced Very High Resolution Radiometer (AVHRR) data were recorded during the 1985 ice-free period. The satellite data coincided with shipboard measurements acquired by Inner Self Transfer and Recycling scientists. Circumstances were such, that on July 5 and July 22, all three sensors recorded data that has been registered to a common map projection and map base, then contrast stretched, color composited, and density sliced.

WE-A-BRD-01: Innovation in Radiation Therapy Planning I: Knowledge Guided Treatment Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Q; Olsen, L

2014-06-15

Intensity modulated radiation therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) offer the capability of normal tissues and organs sparing. However, the exact amount of sparing is often unknown until the plan is complete. This lack of prior guidance has led to the iterative, trial and-error approach in current planning practice. Even with this effort the search for patient-specific optimal organ sparing is still strongly influenced by planner's experience. While experience generally helps in maximizing the dosimetric advantages of IMRT/VMAT, there have been several reports showing unnecessarily high degree of plan quality variability at individual institutions and amongst different institutions,more » even with a large amount of experience and the best available tools. Further, when physician and physicist evaluate a plan, the dosimetric quality of the plan is often compared with a standard protocol that ignores individual patient anatomy and tumor characteristic variations. In recent years, developments of knowledge models for clinical IMRT/VMAT planning guidance have shown promising clinical potentials. These knowledge models extract past expert clinical experience into mathematical models that predict dose sparing references at patient-specific level. For physicians and planners, these references provide objective values that reflect best achievable dosimetric constraints. For quality assurance, applying patient-specific dosimetry requirements will enable more quantitative and objective assessment of protocol compliance for complex IMRT planning. Learning Objectives: Modeling and representation of knowledge for knowledge-guided treatment planning. Demonstrations of knowledge-guided treatment planning with a few clinical caanatomical sites. Validation and evaluation of knowledge models for cost and quality effective standardization of plan optimization.« less

Visual object naming in patients with small lesions centered at the left temporopolar region.

PubMed

Campo, Pablo; Poch, Claudia; Toledano, Rafael; Igoa, José Manuel; Belinchón, Mercedes; García-Morales, Irene; Gil-Nagel, Antonio

2016-01-01

Naming is considered a left hemisphere function that operates according to a posterior-anterior specificity gradient, with more fine-grained information processed in most anterior regions of the temporal lobe (ATL), including the temporal pole (TP). Word finding difficulties are typically assessed using visual confrontation naming tasks, and have been associated with selective damage to ATL resulting from different aetiologies. Nonetheless, the role of the ATL and, more specifically, of the TP in the naming network is not completely established. Most of the accumulated evidence is based on studies on patients with extensive lesions, often bilateral. Furthermore, there is a considerable variability in the anatomical definition of ATL. To better understand the specific involvement of the left TP in visual object naming, we assessed a group of patients with an epileptogenic lesion centered at the TP, and compared their performance with that of a strictly matched control group. We also administered a battery of verbal and non-verbal semantic tasks that was used as a semantic memory baseline. Patients showed an impaired naming ability, manifesting in a certain degree of anomia and semantically related naming errors, which was influenced by concept familiarity. This pattern took place in a context of mild semantic dysfunction that was evident in different types and modalities of semantic tasks. Therefore, current findings demonstrate that a restricted lesion to the left TP can cause a significant deficit in object naming. Of importance, the observed semantic impairment was far from the devastating degradation observed in semantic dementia and other bilateral conditions.

Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?

PubMed

Mueller, Ralf S; Olivry, Thierry

2017-08-30

The gold standard to diagnose adverse food reactions (AFRs) in the dog and cat is currently an elimination diet with subsequent provocation trials. However, those trials are inconvenient and client compliance can be low. Our objective was to systematically review the literature to evaluate in vivo and in vitro tests used to diagnose AFR in small animals. We searched three databases (CAB Abstracts, MEDLINE and Web of Science) for pertinent references on September 16, 2016. Among 71, 544 and 41 articles found in the CAB Abstract, MEDLINE and Web of Science databases, respectively, we selected 22 articles and abstracts from conference proceedings that reported data usable for evaluation of tests for AFR. Serum tests for food-specific IgE and IgG, intradermal testing with food antigens, lymphocyte proliferation tests, fecal food-specific IgE, patch, gastroscopic, and colonoscopic testing were evaluated. Testing for serum food-specific IgE and IgG showed low repeatability and, in dogs, a highly variable accuracy. In cats, the accuracy of testing for food-specific IgE was low. Lymphocyte proliferation tests were more frequently positive and more accurate in animals with AFR, but, as they are more difficult to perform, they remain currently a research tool. All other reported tests were only evaluated by individual studies with small numbers of animals. Negative patch test reactions have a very high negative predictability in dogs and could enable a choice of ingredients for the elimination diet in selected patients. Gastroscopic and colonoscopic testing as well as food-specific fecal IgE or food-specific serum IgG measurements appear less useful. Currently, the best diagnostic procedure to identify AFRs in small animals remains an elimination diet with subsequent provocation trials.

Adult Current Smoking: Differences in Definitions and Prevalence Estimates—NHIS and NSDUH, 2008

PubMed Central

Ryan, Heather; Trosclair, Angela; Gfroerer, Joe

2012-01-01

Objectives. To compare prevalence estimates and assess issues related to the measurement of adult cigarette smoking in the National Health Interview Survey (NHIS) and the National Survey on Drug Use and Health (NSDUH). Methods. 2008 data on current cigarette smoking and current daily cigarette smoking among adults ≥18 years were compared. The standard NHIS current smoking definition, which screens for lifetime smoking ≥100 cigarettes, was used. For NSDUH, both the standard current smoking definition, which does not screen, and a modified definition applying the NHIS current smoking definition (i.e., with screen) were used. Results. NSDUH consistently yielded higher current cigarette smoking estimates than NHIS and lower daily smoking estimates. However, with use of the modified NSDUH current smoking definition, a notable number of subpopulation estimates became comparable between surveys. Younger adults and racial/ethnic minorities were most impacted by the lifetime smoking screen, with Hispanics being the most sensitive to differences in smoking variable definitions among all subgroups. Conclusions. Differences in current cigarette smoking definitions appear to have a greater impact on smoking estimates in some sub-populations than others. Survey mode differences may also limit intersurvey comparisons and trend analyses. Investigators are cautioned to use data most appropriate for their specific research questions. PMID:22649464

The sonar aperture and its neural representation in bats.

PubMed

Heinrich, Melina; Warmbold, Alexander; Hoffmann, Susanne; Firzlaff, Uwe; Wiegrebe, Lutz

2011-10-26

As opposed to visual imaging, biosonar imaging of spatial object properties represents a challenge for the auditory system because its sensory epithelium is not arranged along space axes. For echolocating bats, object width is encoded by the amplitude of its echo (echo intensity) but also by the naturally covarying spread of angles of incidence from which the echoes impinge on the bat's ears (sonar aperture). It is unclear whether bats use the echo intensity and/or the sonar aperture to estimate an object's width. We addressed this question in a combined psychophysical and electrophysiological approach. In three virtual-object playback experiments, bats of the species Phyllostomus discolor had to discriminate simple reflections of their own echolocation calls differing in echo intensity, sonar aperture, or both. Discrimination performance for objects with physically correct covariation of sonar aperture and echo intensity ("object width") did not differ from discrimination performances when only the sonar aperture was varied. Thus, the bats were able to detect changes in object width in the absence of intensity cues. The psychophysical results are reflected in the responses of a population of units in the auditory midbrain and cortex that responded strongest to echoes from objects with a specific sonar aperture, regardless of variations in echo intensity. Neurometric functions obtained from cortical units encoding the sonar aperture are sufficient to explain the behavioral performance of the bats. These current data show that the sonar aperture is a behaviorally relevant and reliably encoded cue for object size in bat sonar.

Specificity revisited and updated.

PubMed

Paulley, J W

1991-01-01

Typicality is probably a better representation of Alexander, Dunbar and others' conclusions than specificity, which was always too absolute a term. As such it became a valid cause of objection by opponents. No genuine attempts to repeat the original studies have been made and most of the original opposition to the concept is now acknowledged as invalid. Typicality (specificity) in psychosomatic disorders appears to be conferred by coping mechanisms acquired through interaction with mother and early surrogates in infancy and childhood as a means of reducing tensions and restoration of homeostatic emotional equilibrium. Psychosomatic medicine patients share one such mechanism, notably superstability/alexythymia, but contained within it are coping mechanisms typical for differing disorders. Examples are listed, and also mention of typicality of recurrently provocative life events/situations. Until typicality is appreciated, taught, learned and practised, success in management of psychosomatic disorders will be limited. The current bio-psycho-social approach is too imprecise.

Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke

PubMed Central

Hecht, S

2004-01-01

Objective: To review the literature on carcinogen derived biomarkers of exposure to secondhand tobacco smoke (SHS). These biomarkers are specifically related to known carcinogens in tobacco smoke and include urinary metabolites, DNA adducts, and blood protein adducts. Method: Published reviews and the current literature were searched for relevant articles. Results: The most consistently elevated biomarker in people exposed to SHS was 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Gluc), urinary metabolites of the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The tobacco specificity of this biomarker as well as its clear relation to an established lung carcinogen are particularly appropriate for its application in studies of SHS exposure. Conclusion: The results of the available carcinogen derived biomarker studies provide biochemical data which support the conclusion, based on epidemiologic investigations, that SHS causes lung cancer in non-smokers. PMID:14985617

Validity and everyday clinical applicability of lumbar muscle fatigue assessment methods in patients with chronic non-specific low back pain: a systematic review.

PubMed

Villafañe, Jorge H; Gobbo, Massimiliano; Peranzoni, Matteo; Naik, Ganesh; Imperio, Grace; Cleland, Joshua A; Negrini, Stefano

2016-09-01

This systematic literature review aimed at examining the validity and applicability in everyday clinical rehabilitation practise of methods for the assessment of back muscle fatiguability in patients with chronic non-specific low back pain (CNSLBP). Extensive research was performed in MEDLINE, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Embase, Physiotherapy Evidence Database (PEDro) and Cochrane Central Register of Controlled Trials (CENTRAL) databases from their inception to September 2014. Potentially relevant articles were also manually looked for in the reference lists of the identified publications. Studies examining lumbar muscle fatigue in people with CNSLBP were selected. Two reviewers independently selected the articles, carried out the study quality assessment and extracted the results. A modified Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) scale was used to evaluate the scientific rigour of the selected works. Twenty-four studies fulfilled the selection criteria and were included in the systematic review. We found conflicting data regarding the validity of methods used to examine back muscle fatigue. The Biering-Sorensen test, performed in conjunction with surface electromyography spectral analysis, turned out to be the most widely used and comparatively, the most optimal modality currently available to assess objective back muscle fatigue in daily clinical practise, even though critical limitations are discussed. Future research should address the identification of an advanced method for lower back fatigue assessment in patients with CNSLBP which, eventually, might provide physical therapists with an objective and reliable test usable in everyday clinical practise. Implications for Rehabilitation Despite its limitations, the Biering-Sorensen test is currently the most used, convenient and easily available fatiguing test for lumbar muscles. To increase validity and reliability of the Biering-Sorensen test, concomitant activation of synergistic muscles should be taken into account. Pooled mean frequency and half-width of the spectrum are currently the most valid electromyographic parameters to assess fatigue in chronic non-specific low back pain. Body mass index, grading of pain and level of disability of the study population should be reported to enhance research quality.

Python package for model STructure ANalysis (pySTAN)

NASA Astrophysics Data System (ADS)

Van Hoey, Stijn; van der Kwast, Johannes; Nopens, Ingmar; Seuntjens, Piet

2013-04-01

The selection and identification of a suitable hydrological model structure is more than fitting parameters of a model structure to reproduce a measured hydrograph. The procedure is highly dependent on various criteria, i.e. the modelling objective, the characteristics and the scale of the system under investigation as well as the available data. Rigorous analysis of the candidate model structures is needed to support and objectify the selection of the most appropriate structure for a specific case (or eventually justify the use of a proposed ensemble of structures). This holds both in the situation of choosing between a limited set of different structures as well as in the framework of flexible model structures with interchangeable components. Many different methods to evaluate and analyse model structures exist. This leads to a sprawl of available methods, all characterized by different assumptions, changing conditions of application and various code implementations. Methods typically focus on optimization, sensitivity analysis or uncertainty analysis, with backgrounds from optimization, machine-learning or statistics amongst others. These methods also need an evaluation metric (objective function) to compare the model outcome with some observed data. However, for current methods described in literature, implementations are not always transparent and reproducible (if available at all). No standard procedures exist to share code and the popularity (and amount of applications) of the methods is sometimes more dependent on the availability than the merits of the method. Moreover, new implementations of existing methods are difficult to verify and the different theoretical backgrounds make it difficult for environmental scientists to decide about the usefulness of a specific method. A common and open framework with a large set of methods can support users in deciding about the most appropriate method. Hence, it enables to simultaneously apply and compare different methods on a fair basis. We developed and present pySTAN (python framework for STructure Analysis), a python package containing a set of functions for model structure evaluation to provide the analysis of (hydrological) model structures. A selected set of algorithms for optimization, uncertainty and sensitivity analysis is currently available, together with a set of evaluation (objective) functions and input distributions to sample from. The methods are implemented model-independent and the python language provides the wrapper functions to apply administer external model codes. Different objective functions can be considered simultaneously with both statistical metrics and more hydrology specific metrics. By using so-called reStructuredText (sphinx documentation generator) and Python documentation strings (docstrings), the generation of manual pages is semi-automated and a specific environment is available to enhance both the readability and transparency of the code. It thereby enables a larger group of users to apply and compare these methods and to extend the functionalities.

Use of ProteinChip technology for identifying biomarkers of parasitic diseases: the example of porcine cysticercosis (Taenia solium).

PubMed

Deckers, N; Dorny, P; Kanobana, K; Vercruysse, J; Gonzalez, A E; Ward, B; Ndao, M

2008-12-01

Taenia solium cysticercosis is a significant public health problem in endemic countries. The current serodiagnostic techniques are not able to differentiate between infections with viable cysts and infections with degenerated cysts. The objectives of this study were to identify specific novel biomarkers of these different disease stages in the serum of experimentally infected pigs using ProteinChip technology (Bio-Rad) and to validate these biomarkers by analyzing serum samples from naturally infected pigs. In the experimental sample set 30 discriminating biomarkers (p<0.05) were found, 13 specific for the viable phenotype, 9 specific for the degenerated phenotype and 8 specific for the infected phenotype (either viable or degenerated cysts). Only 3 of these biomarkers were also significant in the field samples; however, the peak profiles were not consistent among the two sample sets. Five biomarkers discovered in the sera from experimentally infected pigs were identified as clusterin, lecithin-cholesterol acyltransferase, vitronectin, haptoglobin and apolipoprotein A-I.

Immunoconjugates against solid tumors: mind the gap.

PubMed

Ricart, A D

2011-04-01

The objective of immunoconjugate development is to combine the specificity of immunoglobulins with the efficacy of cytotoxic molecules. This therapeutic approach has been validated in hematologic malignancies; however, several obstacles to achieving efficacy in treating solid tumors have been identified. These include insufficient specificity of targets and poor antibody delivery, most specifically to the tumor core. Heterogeneous antigen expression, imperfect vascular supply, and elevated interstitial fluid pressure have been suggested as the factors responsible for the poor delivery of antibodies. Promising immunoconjugates are in development: immunoconjugates targeting the prostate-specific membrane antigen, trastuzumab-DM1, lorvotuzumab mertansine, and SS1P. Advances in cancer biology and antibody engineering may overcome some of the challenges. New small antibody formats, such as single-chain Fv, Fab, and diabodies, may improve penetration within tumor masses. Nevertheless, the cost of treatment might require justification in terms of demonstrable improvement in quality of life in addition to efficacy; further economic evaluation might be necessary before this approach can replace the current standards of care in clinical practice.

Preschool Children’s Memory for Word Forms Remains Stable Over Several Days, but Gradually Decreases after 6 Months

PubMed Central

Gordon, Katherine R.; McGregor, Karla K.; Waldier, Brigitte; Curran, Maura K.; Gomez, Rebecca L.; Samuelson, Larissa K.

2016-01-01

Research on word learning has focused on children’s ability to identify a target object when given the word form after a minimal number of exposures to novel word-object pairings. However, relatively little research has focused on children’s ability to retrieve the word form when given the target object. The exceptions involve asking children to recall and produce forms, and children typically perform near floor on these measures. In the current study, 3- to 5-year-old children were administered a novel test of word form that allowed for recognition memory and manual responses. Specifically, when asked to label a previously trained object, children were given three forms to choose from: the target, a minimally different form, and a maximally different form. Children demonstrated memory for word forms at three post-training delays: 10 mins (short-term), 2–3 days (long-term), and 6 months to 1 year (very long-term). However, children performed worse at the very long-term delay than the other time points, and the length of the very long-term delay was negatively related to performance. When in error, children were no more likely to select the minimally different form than the maximally different form at all time points. Overall, these results suggest that children remember word forms that are linked to objects over extended post-training intervals, but that their memory for the forms gradually decreases over time without further exposures. Furthermore, memory traces for word forms do not become less phonologically specific over time; rather children either identify the correct form, or they perform at chance. PMID:27729880

Objective detection of apoptosis in rat renal tissue sections using light microscopy and free image analysis software with subsequent machine learning: Detection of apoptosis in renal tissue.

PubMed

Macedo, Nayana Damiani; Buzin, Aline Rodrigues; de Araujo, Isabela Bastos Binotti Abreu; Nogueira, Breno Valentim; de Andrade, Tadeu Uggere; Endringer, Denise Coutinho; Lenz, Dominik

2017-02-01

The current study proposes an automated machine learning approach for the quantification of cells in cell death pathways according to DNA fragmentation. A total of 17 images of kidney histological slide samples from male Wistar rats were used. The slides were photographed using an Axio Zeiss Vert.A1 microscope with a 40x objective lens coupled with an Axio Cam MRC Zeiss camera and Zen 2012 software. The images were analyzed using CellProfiler (version 2.1.1) and CellProfiler Analyst open-source software. Out of the 10,378 objects, 4970 (47,9%) were identified as TUNEL positive, and 5408 (52,1%) were identified as TUNEL negative. On average, the sensitivity and specificity values of the machine learning approach were 0.80 and 0.77, respectively. Image cytometry provides a quantitative analytical alternative to the more traditional qualitative methods more commonly used in studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

CO2 Suppression of PMMA Flames In Low-Gravity

NASA Technical Reports Server (NTRS)

Ruff, G. A.; Hicks, M.; Mell, W.; Pettegrew, R.; Malcolm, A.

2003-01-01

Even though much has been learned about the effects of microgravity on material flammability, flame spread, and suppressant effectiveness, uncertainties remain regarding some of the practical aspects of fire protection in spacecraft. The experiments and simulations underway in this project are aimed directly at testing, understanding and improving NASA's existing policies and practices toward fire safety in spacecraft and extraterrestrial habitats. Specifically, the objectives of this research are: 1) Determine systematically the conditions that will ignite onboard flammable materials upon passage of an initial premixed gas, firebrand, or aerosol flame over these materials; 2) Test the effect of firebrands and configuration spacing; and 3) Determine the effectiveness of the flow of CO2 extinguisher or other extinguishing agents. Experimental and computational investigations are planned to achieve each of the three objectives above. Even though progress has been made in all of the areas, the majority of data has been collected for objective (3). Current results from these investigations are discussed.

15-month-olds' transfer of learning between touch screen and real-world displays: language cues and cognitive loads.

PubMed

Zack, Elizabeth; Gerhardstein, Peter; Meltzoff, Andrew N; Barr, Rachel

2013-02-01

Infants have difficulty transferring information between 2D and 3D sources. The current study extends Zack, Barr, Gerhardstein, Dickerson & Meltzoff's (2009) touch screen imitation task to examine whether the addition of specific language cues significantly facilitates 15-month-olds' transfer of learning between touch screens and real-world 3D objects. The addition of two kinds of linguistic cues (object label plus verb or nonsense name) did not elevate action imitation significantly above levels observed when such language cues were not used. Language cues hindered infants' performance in the 3D→2D direction of transfer, but only for the object label plus verb condition. The lack of a facilitative effect of language is discussed in terms of competing cognitive loads imposed by conjointly transferring information across dimensions and processing linguistic cues in an action imitation task at this age. © 2012 The Authors. Scandinavian Journal of Psychology © 2012 The Scandinavian Psychological Associations.

An Object-Relational Ifc Storage Model Based on Oracle Database

NASA Astrophysics Data System (ADS)

Li, Hang; Liu, Hua; Liu, Yong; Wang, Yuan

2016-06-01

With the building models are getting increasingly complicated, the levels of collaboration across professionals attract more attention in the architecture, engineering and construction (AEC) industry. In order to adapt the change, buildingSMART developed Industry Foundation Classes (IFC) to facilitate the interoperability between software platforms. However, IFC data are currently shared in the form of text file, which is defective. In this paper, considering the object-based inheritance hierarchy of IFC and the storage features of different database management systems (DBMS), we propose a novel object-relational storage model that uses Oracle database to store IFC data. Firstly, establish the mapping rules between data types in IFC specification and Oracle database. Secondly, design the IFC database according to the relationships among IFC entities. Thirdly, parse the IFC file and extract IFC data. And lastly, store IFC data into corresponding tables in IFC database. In experiment, three different building models are selected to demonstrate the effectiveness of our storage model. The comparison of experimental statistics proves that IFC data are lossless during data exchange.

Systematic Review of Patient-Specific Surgical Simulation: Toward Advancing Medical Education.

PubMed

Ryu, Won Hyung A; Dharampal, Navjit; Mostafa, Ahmed E; Sharlin, Ehud; Kopp, Gail; Jacobs, William Bradley; Hurlbert, Robin John; Chan, Sonny; Sutherland, Garnette R

Simulation-based education has been shown to be an effective tool to teach foundational technical skills in various surgical specialties. However, most of the current simulations are limited to generic scenarios and do not allow continuation of the learning curve beyond basic technical skills to prepare for more advanced expertise, such as patient-specific surgical planning. The objective of this study was to evaluate the current medical literature with respect to the utilization and educational value of patient-specific simulations for surgical training. We performed a systematic review of the literature using Pubmed, Embase, and Scopus focusing on themes of simulation, patient-specific, surgical procedure, and education. The study included randomized controlled trials, cohort studies, and case-control studies published between 2005 and 2016. Two independent reviewers (W.H.R. and N.D) conducted the study appraisal, data abstraction, and quality assessment of the studies. The search identified 13 studies that met the inclusion criteria; 7 studies employed computer simulations and 6 studies used 3-dimensional (3D) synthetic models. A number of surgical specialties evaluated patient-specific simulation, including neurosurgery, vascular surgery, orthopedic surgery, and interventional radiology. However, most studies were small in size and primarily aimed at feasibility assessments and early validation. Early evidence has shown feasibility and utility of patient-specific simulation for surgical education. With further development of this technology, simulation-based education may be able to support training of higher-level competencies outside the clinical settingto aid learners in their development of surgical skills. Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Searching for moving objects in HSC-SSP: Pipeline and preliminary results

NASA Astrophysics Data System (ADS)

Chen, Ying-Tung; Lin, Hsing-Wen; Alexandersen, Mike; Lehner, Matthew J.; Wang, Shiang-Yu; Wang, Jen-Hung; Yoshida, Fumi; Komiyama, Yutaka; Miyazaki, Satoshi

2018-01-01

The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is currently the deepest wide-field survey in progress. The 8.2 m aperture of the Subaru telescope is very powerful in detecting faint/small moving objects, including near-Earth objects, asteroids, centaurs and Tran-Neptunian objects (TNOs). However, the cadence and dithering pattern of the HSC-SSP are not designed for detecting moving objects, making it difficult to do so systematically. In this paper, we introduce a new pipeline for detecting moving objects (specifically TNOs) in a non-dedicated survey. The HSC-SSP catalogs are sliced into HEALPix partitions. Then, the stationary detections and false positives are removed with a machine-learning algorithm to produce a list of moving object candidates. An orbit linking algorithm and visual inspections are executed to generate the final list of detected TNOs. The preliminary results of a search for TNOs using this new pipeline on data from the first HSC-SSP data release (2014 March to 2015 November) present 231 TNO/Centaurs candidates. The bright candidates with Hr < 7.7 and i > 5 show that the best-fitting slope of a single power law to absolute magnitude distribution is 0.77. The g - r color distribution of hot HSC-SSP TNOs indicates a bluer peak at g - r = 0.9, which is consistent with the bluer peak of the bimodal color distribution in literature.

Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy

PubMed Central

Tahmasbi, Amir; Ward, E. Sally; Ober, Raimund J.

2015-01-01

Fluorescence microscopy is a photon-limited imaging modality that allows the study of subcellular objects and processes with high specificity. The best possible accuracy (standard deviation) with which an object of interest can be localized when imaged using a fluorescence microscope is typically calculated using the Cramér-Rao lower bound, that is, the inverse of the Fisher information. However, the current approach for the calculation of the best possible localization accuracy relies on an analytical expression for the image of the object. This can pose practical challenges since it is often difficult to find appropriate analytical models for the images of general objects. In this study, we instead develop an approach that directly uses an experimentally collected image set to calculate the best possible localization accuracy for a general subcellular object. In this approach, we fit splines, i.e. smoothly connected piecewise polynomials, to the experimentally collected image set to provide a continuous model of the object, which can then be used for the calculation of the best possible localization accuracy. Due to its practical importance, we investigate in detail the application of the proposed approach in single molecule fluorescence microscopy. In this case, the object of interest is a point source and, therefore, the acquired image set pertains to an experimental point spread function. PMID:25837101

Comet/Asteroid Protection System (CAPS): Preliminary Space-Based Concept and Study Results

NASA Technical Reports Server (NTRS)

Mazanek, Daniel D.; Roithmayr, Carlos M.; Antol, Jeffrey; Park, Sang-Young; Koons, Robert H.; Bremer, James C.; Murphy, Douglas G.; Hoffman, James A.; Kumar, Renjith R.; Seywald, Hans

2005-01-01

There exists an infrequent, but significant hazard to life and property due to impacting asteroids and comets. There is currently no specific search for long-period comets, smaller near-Earth asteroids, or smaller short-period comets. These objects represent a threat with potentially little or no warning time using conventional ground-based telescopes. These planetary bodies also represent a significant resource for commercial exploitation, long-term sustained space exploration, and scientific research. The Comet/Asteroid Protection System (CAPS) is a future space-based system concept that provides permanent, continuous asteroid and comet monitoring, and rapid, controlled modification of the orbital trajectories of selected bodies. CAPS would expand the current detection effort to include long-period comets, as well as small asteroids and short-period comets capable of regional destruction. A space-based detection system, despite being more costly and complex than Earth-based initiatives, is the most promising way of expanding the range of detectable objects, and surveying the entire celestial sky on a regular basis. CAPS would provide an orbit modification system capable of diverting kilometer class objects, and modifying the orbits of smaller asteroids for impact defense and resource utilization. This Technical Memorandum provides a compilation of key related topics and analyses performed during the CAPS study, which was performed under the Revolutionary Aerospace Systems Concepts (RASC) program, and discusses technologies that could enable the implementation of this future system.

Role for Ion Transport in Porcine Vocal Fold Epithelial Defense to Acid Challenge

PubMed Central

Erickson-Levendoski, Elizabeth; Sivasankar, M. Preeti

2012-01-01

Objective The vocal fold epithelium is routinely exposed to gastric contents, including acid and pepsin, during laryngopharyngeal reflux events. The epithelium may possess intrinsic defenses to reflux. The first objective of the current study was to examine whether vocal fold epithelial ion transport is one potential mechanism of defense to gastric contents. The second objective was to determine whether ion transport in response to gastric contents is associated with the secretion of bicarbonate. Study Design Prospective design in excised porcine larynges. Setting Laboratory. Subjects and Methods Porcine vocal folds (N = 56) were exposed on the luminal surface to acid, pepsin, or sham challenges. Ion transport at baseline and following challenge exposure was measured using electrophysiological techniques. To examine specific ion transport mechanisms, vocal folds were pretreated with either a sodium channel blocker or bicarbonate channel blocker. Results Within 60 seconds of acid but not pepsin exposure, there was a significant increase in ion transport. This rapid increase in ion transport was transient and related to bicarbonate secretion. Conclusion The current data suggest that porcine vocal folds immediately increase bicarbonate secretion following exposure to acid. Bicarbonate secretion may act to neutralize acid. These findings contribute to the identification of the mechanisms underlying vocal fold defense to reflux and offer implications for the development of treatments for reflux-induced vocal fold injury. PMID:22086905

Assessing the validity and reliability of self-report data on contraception use in the MObile Technology for Improved Family Planning (MOTIF) randomised controlled trial.

PubMed

Smith, Chris; Edwards, Phil; Free, Caroline

2018-03-15

A variety of different approaches to measuring contraceptive use have been used or proposed, either to assess current use or adherence over time, using subjective or objective measures. This paper reports an overview of approaches to measuring adherence to the oral contraceptive, intra-uterine device, sub-dermal implant, and injectable and describes how we assessed contraception use in the MObile Technology for Improved Family Planning (MOTIF) trial in Cambodia. We summarise and discuss advantages and disadvantages of different subjective and objective approaches to measuring adherence to the oral contraceptive, intra-uterine device, sub-dermal implant, and injectable such as self-reports, clinic records, electronic monitoring devices, clinical examination and biomarkers. For the MOTIF trial, we did not consider it feasible to measure objective contraception use as many participants lived a long distance from the clinic and we were concerned whether it was appropriate to ask women to return to clinic for a physical examination simply to verify self-report information already provided. We aimed to assess the validity of the four-month data with 50 participants, calculating the sensitivity and specificity of self-reported data compared with objective measurement. For the 46 valid measurements obtained, the sensitivity and specificity was 100% for self-reported contraception use compared to objective measurement but this study had some limitations. To assess reliability of self-report data we compared calendar data collected on effective contraception use at months 1-4 post-abortion, collected separately at four and 12 months. Agreement ranged from 80 to 84% with a kappa statistic ranging from 0·59 to 0·67 indicating fair to good agreement. There is no perfect method of assessing contraception use and researchers designing future studies should give consideration of what to measure, for example current use or detailed patterns of use over time, and remain mindful of what will be feasible and acceptable to the study population. Although self-reported data on contraception use are considered less reliable, and prone to social desirability bias, it is often the standard approach for contraception research and provides data comparable to previous studies. ClinicalTrials.gov Identifier: NCT01823861 . Registered: March 30, 2013.

Neurobiological Correlates in Forensic Assessment: A Systematic Review

PubMed Central

van der Gronde, Toon; Kempes, Maaike; van El, Carla; Rinne, Thomas; Pieters, Toine

2014-01-01

Background With the increased knowledge of biological risk factors, interest in including this information in forensic assessments is growing. Currently, forensic assessments are predominantly focused on psychosocial factors. A better understanding of the neurobiology of violent criminal behaviour and biological risk factors could improve forensic assessments. Objective To provide an overview of the current evidence about biological risk factors that predispose people to antisocial and violent behaviour, and determine its usefulness in forensic assessment. Methods A systematic literature search was conducted using articles from PsycINFO, Embase and Pubmed published between 2000 and 2013. Results This review shows that much research on the relationship between genetic predisposition and neurobiological alterations with aggression is performed on psychiatric patients or normal populations. However, the number of studies comparing offenders is limited. There is still a great need to understand how genetic and neurobiological alterations and/or deficits are related to violent behaviour, specifically criminality. Most studies focus on only one of the genetic or neurobiological fields related to antisocial and/or violent behaviour. To reliably correlate the findings of these fields, a standardization of methodology is urgently needed. Conclusion Findings from the current review suggest that violent aggression, like all forms of human behaviour, both develops under specific genetic and environmental conditions, and requires interplay between these conditions. Violence should be considered as the end product of a chain of life events, during which risks accumulate and potentially reinforce each other, displaying or triggering a specific situation. This systematic review did not find evidence of predispositions or neurobiological alterations that solely explain antisocial or violent behaviour. With better designed studies, more correlation between diverse fields, and more standardisation, it might be possible to elucidate underlying mechanisms. Thus, we advocate maintaining the current case-by-case differentiated approach to evidence-based forensic assessment. PMID:25330208

Die Steuerung von den Multigenerationteams in den Industriebetrieben

NASA Astrophysics Data System (ADS)

Vraňaková, Natália; Chlpeková, Andrea; Koltnerová, Kristína; Pračková, Petra

2017-09-01

The current workforce in industrial enterprises is formed from four generational groups. These generational groups are called Baby boomers, Generation "X", Generation "Y" and Generation "Z". Each of generational groups is specific by own characteristics, positives and negatives. The aim of the article is to refer the features of individual generational groups, to analyze their representation on labor market and to specify recommendations for the management of multigenerational teams for the practice of industrial enterprises in order to achieve the satisfaction and synergy of employees in accordance with the objectives of enterprise.

Earth Science Missions Engineering Challenges

NASA Technical Reports Server (NTRS)

Marius, Julio L.

2009-01-01

This presentation gives a general overlook of the engineering efforts that are necessary to meet science mission requirement especially for Earth Science missions. It provides brief overlook of NASA's current missions and future Earth Science missions and the engineering challenges to meet some of the specific science objectives. It also provides, if time permits, a brief summary of two significant weather and climate phenomena in the Southern Hemisphere: El Nino and La Nina, as well as the Ozone depletion over Antarctica that will be of interest to IEEE intercom 2009 conference audience.

GASB proposes new standards for financial reporting of postemployment benefits by state and local governments.

PubMed

Johnson, Karl D

2003-03-01

GASB has proposed new standards that will affect the way in which governments report postemployment health care benefits in audited external financial statements, resulting in more complete and transparent reporting by employers and plans and more relevant and useful information for the users of governmental financial reports. This article provides an overview of current financial reporting standards and practice, the financial reporting objectives of the project, the proposed measurement approach, noteworthy specific proposals, and the projected timetable for completion of the project and implementation of the new standards.

Geocentric solar electric propulsion vehicle design.

NASA Technical Reports Server (NTRS)

Harney, E. D.; Lapins, U. E.; Molitor, J. H.

1972-01-01

Mission applications have been studied that use solar electric propulsion (SEP) to inject payloads into geocentric orbits. Two specific applications feasible with current technology are described that approximate practical bounds for the next decade. In the lower extreme, SEP is used on a Thor-Delta launched satellite to maximize the weight injected into synchronous orbits. In the other extreme, SEP is used in a reusable interorbital tug together with an all-chemical shuttle/tug transportation system. Different trajectory profiles are required to most efficiently accomplish the overall mission objectives in the two cases.

What lessons can operational planners infer from the NATO Partnership for Peace Program for the execution of contemporary US Regionally Aligned Force and UK Adaptable Force Security Cooperation missions

DTIC Science & Technology

2016-05-26

research questions consist of three groups . The first group addresses an analysis of PfP. The second group determines contemporary US and UK strategy...The second group of research questions focuses upon current US, UK security cooperation initiatives and the specific policy objectives they...Ambition, Austerity and the Case for Rethinking UK Military Spending.” Oxford Research Group . Last modified May 13, 2015. Accessed September 17, 2015

Process Based on SysML for New Launchers System and Software Developments

NASA Astrophysics Data System (ADS)

Hiron, Emmanuel; Miramont, Philippe

2010-08-01

The purpose of this paper is to present the Astrium-ST engineering process based on SysML. This process is currently set-up in the frame of common CNES /Astrium-ST R&T studies related to the Ariane 5 electrical system and flight software modelling. The tool used to set up this process is Rhapsody release 7.3 from IBM-Software firm [1]. This process focuses on the system engineering phase dedicated to Software with the objective to generate both System documents (sequential system design and flight control) and Software specifications.

Design of a clinical notification system.

PubMed

Wagner, M M; Tsui, F C; Pike, J; Pike, L

1999-01-01

We describe the requirements and design of an enterprise-wide notification system. From published descriptions of notification schemes, our own experience, and use cases provided by diverse users in our institution, we developed a set of functional requirements. The resulting design supports multiple communication channels, third party mappings (algorithms) from message to recipient and/or channel of delivery, and escalation algorithms. A requirement for multiple message formats is addressed by a document specification. We implemented this system in Java as a CORBA object. This paper describes the design and current implementation of our notification system.

Family medicine practice in Saudi Arabia: The current situation and Proposed Strategic Directions Plan 2020

PubMed Central

Al-Khaldi, Yahia M.; Al-Ghamdi, Essam A.; Al-Mogbil, Tariq I.; Al-Khashan, Hesham I.

2017-01-01

OBJECTIVES: The objectives of this study were to assess the current situation of the teaching and training of undergraduate and postgraduate programs in family medicine in KSA, assess the current practice of family medicine, and draw a roadmap to achieve Saudi vision 2020. MATERIALS AND METHODS: This study was conducted with the support and collaboration of the Primary Health Care Department of the Ministry of Health, Saudi Arabia, and World Health Organization (EMRO) in November 2015. Based on the literature review of previous studies conducted for similar purposes, relevant questionnaires were developed. These consisted of four forms, each of which was directed at a different authority to achieve the above-mentioned objectives. Data of all questionnaires were coded, entered, and analyzed using SPSS version 16. RESULTS: There are 2282 primary health-care centers (PHCCs), 60% of which are in rural areas. More than half of the PHCCs have a laboratory and more than one-third have a Radiology Department. Out of the 6107 physicians, 636 are family physicians (10%). All medical colleges have a family medicine department with a total staff of 170 medical teachers. Thirteen departments run family medicine courses of 4–8 weeks' duration for students. Fourteen colleges have internship programs in family medicine and four colleges have postgraduate centers for family medicine (27%). There are 95 training centers for Saudi Board (Saudi Board of Family Medicine [SBFM]) and 68 centers for Saudi Diploma (Saudi Diploma of Family Medicine [SDFM]). The total number of trainers was 241, while the total trainees were 756 in SBFM and 137 in SDFM. CONCLUSIONS: This survey showed that there is a shortage of qualified family physicians in all health sectors in Saudi Arabia as a result of the lack of a strategic plan for the training of family physicians. A national strategic plan with specific objectives and an explicit budget are necessary to deal with this shortage and improve the quality of health-care services at PHCCs. PMID:28932160

A ball is not a Kong: Odor representation and search behavior in domestic dogs (Canis familiaris) of different education.

PubMed

Bräuer, Juliane; Belger, Julia

2018-05-01

There has been a growing interest in the cognitive skills of domestic dogs, but most current knowledge about dogs' understanding of their environment is limited to the visual or auditory modality. Although it is well known that dogs have an excellent olfactory sense and that they rely on olfaction heavily when exploring the environment or recognizing individuals, it remains unclear whether dogs perceive odors as representing specific objects. In the current study, we examined this aspect of dogs' perception of the world. Dogs were presented with a violation-of-expectation paradigm in which they could track the odor trail of one target (Target A), but at the end of the trail, they found another target (Target B). We explored (a) what dogs expect when they smell the trail of an object, (b) how they search for an object, and (c) how their educational background influences their ability to find a hidden object, by comparing family dogs and working dogs that had passed exams for police or rescue dogs. We found that all subjects showed a flexible searching behavior, with the working dogs being more effective but the family dogs learning to be effective over trials. In the first trial, dogs showed measurable signs of "surprise" (i.e., further searching for Target A) when they found Target B, which did not correspond to the odor of Target A from the trail. We conclude that dogs represent what they smell and search flexibly, which is independent from their educational background. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder.

PubMed

Uddin, L Q; Dajani, D R; Voorhies, W; Bednarz, H; Kana, R K

2017-08-22

Children with neurodevelopmental disorders benefit most from early interventions and treatments. The development and validation of brain-based biomarkers to aid in objective diagnosis can facilitate this important clinical aim. The objective of this review is to provide an overview of current progress in the use of neuroimaging to identify brain-based biomarkers for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), two prevalent neurodevelopmental disorders. We summarize empirical work that has laid the foundation for using neuroimaging to objectively quantify brain structure and function in ways that are beginning to be used in biomarker development, noting limitations of the data currently available. The most successful machine learning methods that have been developed and applied to date are discussed. Overall, there is increasing evidence that specific features (for example, functional connectivity, gray matter volume) of brain regions comprising the salience and default mode networks can be used to discriminate ASD from typical development. Brain regions contributing to successful discrimination of ADHD from typical development appear to be more widespread, however there is initial evidence that features derived from frontal and cerebellar regions are most informative for classification. The identification of brain-based biomarkers for ASD and ADHD could potentially assist in objective diagnosis, monitoring of treatment response and prediction of outcomes for children with these neurodevelopmental disorders. At present, however, the field has yet to identify reliable and reproducible biomarkers for these disorders, and must address issues related to clinical heterogeneity, methodological standardization and cross-site validation before further progress can be achieved.

Initiating Formal Requirements Specifications with Object-Oriented Models

NASA Technical Reports Server (NTRS)

Ampo, Yoko; Lutz, Robyn R.

1994-01-01

This paper reports results of an investigation into the suitability of object-oriented models as an initial step in developing formal specifications. The requirements for two critical system-level software modules were used as target applications. It was found that creating object-oriented diagrams prior to formally specifying the requirements enhanced the accuracy of the initial formal specifications and reduced the effort required to produce them. However, the formal specifications incorporated some information not found in the object-oriented diagrams, such as higher-level strategy or goals of the software.

A Study to Design, Develop, Implement, Evaluate, and Revise Specific, Measurable Performance Objectives to Serve as a Model to Individualize Instruction for Secondary Schools. Final Report.

ERIC Educational Resources Information Center

Wendt, Marilynn S.; Jacobson, Marjory E.

Specific objectives of this two-phase study included: (1) assessment of design of the behavioral objectives in all secondary level courses; (2) construction of criteria for evaluation of the design; (3) testing of objectives against the evaluative criteria and/or the specifications of the curriculum design; and (4) determination of the validity of…

WE-H-207B-00: MRgRT

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2016-06-15

In recent years, steady progress has been made towards the implementation of MRI in external beam radiation therapy for processes ranging from treatment simulation to in-room guidance. Novel procedures relying mostly on MR data are currently implemented in the clinic. This session will cover topics such as (a) commissioning and quality control of the MR in-room imagers and simulators specific to RT, (b) treatment planning requirements, constraints and challenges when dealing with various MR data, (c) quantification of organ motion with an emphasis on treatment delivery guidance, and (d) MR-driven strategies for adaptive RT workflows. The content of the sessionmore » was chosen to address both educational and practical key aspects of MR guidance. Learning Objectives: Good understanding of MR testing recommended for in-room MR imaging as well as image data validation for RT chain (e.g. image transfer, filtering for consistency, spatial accuracy, manipulation for task specific); Familiarity with MR-based planning procedures: motivation, core workflow requirements, current status, challenges; Overview of the current methods for the quantification of organ motion; Discussion on approaches for adaptive treatment planning and delivery. T. Stanescu - License agreement with Modus Medical Devices to develop a phantom for the quantification of MR image system-related distortions.; T. Stanescu, N/A.« less

WE-H-207B-04: Strategies for Adaptive RT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, O.

2016-06-15

In recent years, steady progress has been made towards the implementation of MRI in external beam radiation therapy for processes ranging from treatment simulation to in-room guidance. Novel procedures relying mostly on MR data are currently implemented in the clinic. This session will cover topics such as (a) commissioning and quality control of the MR in-room imagers and simulators specific to RT, (b) treatment planning requirements, constraints and challenges when dealing with various MR data, (c) quantification of organ motion with an emphasis on treatment delivery guidance, and (d) MR-driven strategies for adaptive RT workflows. The content of the sessionmore » was chosen to address both educational and practical key aspects of MR guidance. Learning Objectives: Good understanding of MR testing recommended for in-room MR imaging as well as image data validation for RT chain (e.g. image transfer, filtering for consistency, spatial accuracy, manipulation for task specific); Familiarity with MR-based planning procedures: motivation, core workflow requirements, current status, challenges; Overview of the current methods for the quantification of organ motion; Discussion on approaches for adaptive treatment planning and delivery. T. Stanescu - License agreement with Modus Medical Devices to develop a phantom for the quantification of MR image system-related distortions.; T. Stanescu, N/A.« less

XMI2USE: A Tool for Transforming XMI to USE Specifications

NASA Astrophysics Data System (ADS)

Sun, Wuliang; Song, Eunjee; Grabow, Paul C.; Simmonds, Devon M.

The UML-based Specification Environment (USE) tool supports syntactic analysis, type checking, consistency checking, and dynamic validation of invariants and pre-/post conditions specified in the Object Constraint Language (OCL). Due to its animation and analysis power, it is useful when checking critical non-functional properties such as security policies. However, the USE tool requires one to specify (i.e., "write") a model using its own textual language and does not allow one to import any model specification files created by other UML modeling tools. Hence, to make the best use of existing UML tools, we often create a model with OCL constraints using a modeling tool such as the IBM Rational Software Architect (RSA) and then use the USE tool for model validation. This approach, however, requires a manual transformation between the specifications of two different tool formats, which is error-prone and diminishes the benefit of automated model-level validations. In this paper, we describe our own implementation of a specification transformation engine that is based on the Model Driven Architecture (MDA) framework and currently supports automatic tool-level transformations from RSA to USE.

Disparities in Risk Factors and Birth Outcomes Among American Indians in North Dakota.

PubMed

Danielson, Ramona A; Wallenborn, Jordyn T; Warne, Donald K; Masho, Saba W

2018-06-23

Objectives High infant mortality rates among American Indians in North Dakota contribute to a 20-year gap in average age at death compared to whites. Geographic- and race-specific health disparities data to drive policy making and interventions are not well disseminated. The current study examines prenatal risk factors and birth outcomes between American Indian and whites in North Dakota. Methods A retrospective descriptive analysis of North Dakota live births from 2007 to 2012 was conducted. Period prevalence and prevalence ratios were calculated. Results The infant mortality rate from 2010 to 2012 for infants born to American Indian women was 3.5 times higher than whites. Racial disparities existed in education, teen births, tobacco use during pregnancy, and breastfeeding initiation. Disparities widened for inadequate prenatal care, illegal drug use during pregnancy, and infant mortality from 2007-2009 to 2010-2012 and narrowed for sexually transmitted infections and alcohol use during pregnancy. Conclusions for Practice American Indians are disproportionately affected by poor pregnancy and birth outcomes in North Dakota. Future geographic-specific American Indian research is warranted to aid current and future public health interventions.

View-Tolerant Face Recognition and Hebbian Learning Imply Mirror-Symmetric Neural Tuning to Head Orientation.

PubMed

Leibo, Joel Z; Liao, Qianli; Anselmi, Fabio; Freiwald, Winrich A; Poggio, Tomaso

2017-01-09

The primate brain contains a hierarchy of visual areas, dubbed the ventral stream, which rapidly computes object representations that are both specific for object identity and robust against identity-preserving transformations, like depth rotations [1, 2]. Current computational models of object recognition, including recent deep-learning networks, generate these properties through a hierarchy of alternating selectivity-increasing filtering and tolerance-increasing pooling operations, similar to simple-complex cells operations [3-6]. Here, we prove that a class of hierarchical architectures and a broad set of biologically plausible learning rules generate approximate invariance to identity-preserving transformations at the top level of the processing hierarchy. However, all past models tested failed to reproduce the most salient property of an intermediate representation of a three-level face-processing hierarchy in the brain: mirror-symmetric tuning to head orientation [7]. Here, we demonstrate that one specific biologically plausible Hebb-type learning rule generates mirror-symmetric tuning to bilaterally symmetric stimuli, like faces, at intermediate levels of the architecture and show why it does so. Thus, the tuning properties of individual cells inside the visual stream appear to result from group properties of the stimuli they encode and to reflect the learning rules that sculpted the information-processing system within which they reside. Copyright © 2017 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jansen, F.

The use of integrated PET/MRI systems in clinical applications can best benefit from understanding their technological advances and limitations. The currently available clinical PET/MRI systems have their own characteristics. Thorough analyses of existing technical data and evaluation of necessary performance metrics for quality assurances could be conducted to optimize application-specific PET/MRI protocols. This Symposium will focus on technical advances and limitations of clinical PET/MRI systems, and how this exciting imaging modality can be utilized in applications that can benefit from both PET and MRI. Learning Objectives: To understand the technological advances of clinical PET/MRI systems To correctly identify clinical applicationsmore » that can benefit from PET/MRI To understand ongoing work to further improve the current PET/MRI technology Floris Jansen is a GE Healthcare employee.« less

Alternative approach for fire suppression of class A, B and C fires in gloveboxes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenberger, Mark S; Tsiagkouris, James A

2011-02-10

Department of Energy (DOE) Orders and National Fire Protection Association (NFPA) Codes and Standards require fire suppression in gloveboxes. Several potential solutions have been and are currently being considered at Los Alamos National Laboratory (LANL). The objective is to provide reliable, minimally invasive, and seismically robust fire suppression capable of extinguishing Class A, B, and C fires; achieve compliance with DOE and NFPA requirements; and provide value-added improvements to fire safety in gloveboxes. This report provides a brief summary of current approaches and also documents the successful fire tests conducted to prove that one approach, specifically Fire Foe{trademark} tubes, ismore » capable of achieving the requirement to provide reliable fire protection in gloveboxes in a cost-effective manner.« less

Discovery of urine biomarkers for bladder cancer via global metabolomics.

PubMed

Shi, Hangchuan; Li, Xiang; Zhang, Qingyang; Yang, Hongmei; Zhang, Xiaoping

2016-11-01

Bladder cancer (BC) is latent in its early stage and lethal in its late stage. Therefore, early diagnosis and intervention are essential for successful BC treatment. Considering the limitations of current diagnostic tools, noninvasive biomarkers that are both highly sensitive and specific are needed to improve the overall survival and quality of life of patients. With the advent of systems biology, "-omics" technologies have been developed over the past few decades. As a promising member, global metabolomics has increasingly been found to have clear potential for biomarker discovery. However, urinary metabolomics studies related to BC have lagged behind those of other urinary cancers, and major findings have not been systematically reported. The objective of this review is to comprehensively list the currently identified potential urinary metabolite biomarkers for BC.

Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia

PubMed Central

Bathgate, Christina J.; Edinger, Jack D.; Wyatt, James K.; Krystal, Andrew D.

2016-01-01

Study Objectives: To examine the relationship between hypertension prevalence in individuals with insomnia who have short total sleep duration < 6 h or sleep duration ≥ 6 h, using both objective and subjective measures of total sleep duration. Methods: Using a cross-sectional, observational design, 255 adult volunteers (n = 165 women; 64.7%) meeting current diagnostic criteria for insomnia disorder (MAge = 46.2 y, SDAge = 13.7 y) participated in this study at two large university medical centers. Two nights of polysomnography, 2 w of sleep diaries, questionnaires focused on sleep, medical, psychological, and health history, including presence/absence of hypertension were collected. Logistic regressions assessed the odds ratios of hypertension among persons with insomnia with short sleep duration < 6 h compared to persons with insomnia with a sleep duration ≥ 6 h, measured both objectively and subjectively. Results: Consistent with previous studies using objective total sleep duration, individuals with insomnia and short sleep duration < 6 h were associated with a 3.59 increased risk of reporting hypertension as a current medical problem as compared to individuals with insomnia with sleep duration ≥ 6 h. Increased risk for hypertension was independent of major confounding factors frequently associated with insomnia or hypertension. No significant risk was observed using subjectively determined total sleep time groups. Receiver operating characteristic curve analysis found that the best balance of sensitivity and specificity using subjective total sleep time was at a 6-h cutoff, but the area under the receiver operating characteristic curve showed low accuracy and did not have good discriminant value. Conclusions: Objectively measured short sleep duration increased the odds of reporting hypertension more than threefold after adjusting for potential confounders; this relationship was not significant for subjectively measured sleep duration. This research supports emerging evidence that insomnia with objective short sleep duration is associated with an increased risk of comorbid hypertension. Citation: Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD. Objective but not subjective short sleep duration associated with increased risk for hypertension in individuals with insomnia. SLEEP 2016;39(5):1037–1045. PMID:26951399

Multi-scale image segmentation method with visual saliency constraints and its application

NASA Astrophysics Data System (ADS)

Chen, Yan; Yu, Jie; Sun, Kaimin

2018-03-01

Object-based image analysis method has many advantages over pixel-based methods, so it is one of the current research hotspots. It is very important to get the image objects by multi-scale image segmentation in order to carry out object-based image analysis. The current popular image segmentation methods mainly share the bottom-up segmentation principle, which is simple to realize and the object boundaries obtained are accurate. However, the macro statistical characteristics of the image areas are difficult to be taken into account, and fragmented segmentation (or over-segmentation) results are difficult to avoid. In addition, when it comes to information extraction, target recognition and other applications, image targets are not equally important, i.e., some specific targets or target groups with particular features worth more attention than the others. To avoid the problem of over-segmentation and highlight the targets of interest, this paper proposes a multi-scale image segmentation method with visually saliency graph constraints. Visual saliency theory and the typical feature extraction method are adopted to obtain the visual saliency information, especially the macroscopic information to be analyzed. The visual saliency information is used as a distribution map of homogeneity weight, where each pixel is given a weight. This weight acts as one of the merging constraints in the multi- scale image segmentation. As a result, pixels that macroscopically belong to the same object but are locally different can be more likely assigned to one same object. In addition, due to the constraint of visual saliency model, the constraint ability over local-macroscopic characteristics can be well controlled during the segmentation process based on different objects. These controls will improve the completeness of visually saliency areas in the segmentation results while diluting the controlling effect for non- saliency background areas. Experiments show that this method works better for texture image segmentation than traditional multi-scale image segmentation methods, and can enable us to give priority control to the saliency objects of interest. This method has been used in image quality evaluation, scattered residential area extraction, sparse forest extraction and other applications to verify its validation. All applications showed good results.

Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia.

PubMed

Bathgate, Christina J; Edinger, Jack D; Wyatt, James K; Krystal, Andrew D

2016-05-01

To examine the relationship between hypertension prevalence in individuals with insomnia who have short total sleep duration < 6 h or sleep duration ≥ 6 h, using both objective and subjective measures of total sleep duration. Using a cross-sectional, observational design, 255 adult volunteers (n = 165 women; 64.7%) meeting current diagnostic criteria for insomnia disorder (MAge = 46.2 y, SDAge = 13.7 y) participated in this study at two large university medical centers. Two nights of polysomnography, 2 w of sleep diaries, questionnaires focused on sleep, medical, psychological, and health history, including presence/absence of hypertension were collected. Logistic regressions assessed the odds ratios of hypertension among persons with insomnia with short sleep duration < 6 h compared to persons with insomnia with a sleep duration ≥ 6 h, measured both objectively and subjectively. Consistent with previous studies using objective total sleep duration, individuals with insomnia and short sleep duration < 6 h were associated with a 3.59 increased risk of reporting hypertension as a current medical problem as compared to individuals with insomnia with sleep duration ≥ 6 h. Increased risk for hypertension was independent of major confounding factors frequently associated with insomnia or hypertension. No significant risk was observed using subjectively determined total sleep time groups. Receiver operating characteristic curve analysis found that the best balance of sensitivity and specificity using subjective total sleep time was at a 6-h cutoff, but the area under the receiver operating characteristic curve showed low accuracy and did not have good discriminant value. Objectively measured short sleep duration increased the odds of reporting hypertension more than threefold after adjusting for potential confounders; this relationship was not significant for subjectively measured sleep duration. This research supports emerging evidence that insomnia with objective short sleep duration is associated with an increased risk of comorbid hypertension. © 2016 Associated Professional Sleep Societies, LLC.

X-ray scatter imaging of hepatocellular carcinoma in a mouse model using nanoparticle contrast agents

DOE PAGES

Rand, Danielle; Derdak, Zoltan; Carlson, Rolf; ...

2015-10-29

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is almost uniformly fatal. Current methods of detection include ultrasound examination and imaging by CT scan or MRI; however, these techniques are problematic in terms of sensitivity and specificity, and the detection of early tumors (<1 cm diameter) has proven elusive. Better, more specific, and more sensitive detection methods are therefore urgently needed. Here we discuss the application of a newly developed x-ray imaging technique called Spatial Frequency Heterodyne Imaging (SFHI) for the early detection of HCC. SFHI uses x-rays scattered by an object to form anmore » image and is more sensitive than conventional absorption-based x-radiography. We show that tissues labeled in vivo with gold nanoparticle contrast agents can be detected using SFHI. We also demonstrate that directed targeting and SFHI of HCC tumors in a mouse model is possible through the use of HCC-specific antibodies. As a result, the enhanced sensitivity of SFHI relative to currently available techniques enables the x-ray imaging of tumors that are just a few millimeters in diameter and substantially reduces the amount of nanoparticle contrast agent required for intravenous injection relative to absorption-based x-ray imaging.« less

from the Adolescents’ Perspective in Malaysia

PubMed

Mohd Zin, Faridah; Hillaluddin, Azlin Hilma; Mustaffa, Jamaludin

2017-05-01

Objective: This study aims to develop, validate and determine the reliability of an interactive multimedia strategy to prevent tobacco use among the young (TUPY-S) from an adolescents’ perspective. Methods: A descriptive study design was utilized. A modular instruction guideline by Russel (1974) was followed in the entire process, comprising a feasibility study, a review of existing modules, specification of the objectives, identification of the construct criterion items, learner analysis and entry behavior specification, establishment of the sequence instruction and media selection, a tryout with students and a field test. Result: Feasibility was agreed among the researchers and the school authorities. Culturally suitable rigorously developed tobacco use preventive strategies delivered using information technology (IT) are lacking in the literature. The objective of TUPY-S is to prevent tobacco use among adolescents living in Malaysia. Identified construct criterion items include knowledge, attitude, intention to use, self-efficacy, and refusal skill. The target population was early adolescents belonging to generation-Z. Content was developed from the adolescents’ perspective and delivered using IT in Malay language. Content validity, assessed by six experts in the field and module development, was good at 86%. The students’ tryout showed satisfactory face validity subjectively and objectively (85.5%) and high alpha Cronbach reliability (0.91). Conclusion: TUPY-S was confirmed to suit early adolescents of the current generation living in Malaysia. It demonstrated good content validity among the experts, satisfactory face validity and reliability among the target population. TUPY-S is ready to be evaluated for its effectiveness among early adolescents. Creative Commons Attribution License

Tobacco Use Prevention for the Young (TUPY-S): Development, Validity and Reliability of an Interactive Multimedia Strategy from the Adolescents’ Perspective in Malaysia

PubMed Central

Zin, Faridah Mohd; Hillaluddin, Azlin Hilma; Mustaffa, Jamaludin

2017-01-01

Objective: This study aims to develop, validate and determine the reliability of an interactive multimedia strategy to prevent tobacco use among the young (TUPY-S) from an adolescents’ perspective. Methods: A descriptive study design was utilized. A modular instruction guideline by Russel (1974) was followed in the entire process, comprising a feasibility study, a review of existing modules, specification of the objectives, identification of the construct criterion items, learner analysis and entry behavior specification, establishment of the sequence instruction and media selection, a tryout with students and a field test. Result: Feasibility was agreed among the researchers and the school authorities. Culturally suitable rigorously developed tobacco use preventive strategies delivered using information technology (IT) are lacking in the literature. The objective of TUPY-S is to prevent tobacco use among adolescents living in Malaysia. Identified construct criterion items include knowledge, attitude, intention to use, self-efficacy, and refusal skill. The target population was early adolescents belonging to generation-Z. Content was developed from the adolescents’ perspective and delivered using IT in Malay language. Content validity, assessed by six experts in the field and module development, was good at 86%. The students’ tryout showed satisfactory face validity subjectively and objectively (85.5%) and high alpha Cronbach reliability (0.91). Conclusion: TUPY-S was confirmed to suit early adolescents of the current generation living in Malaysia. It demonstrated good content validity among the experts, satisfactory face validity and reliability among the target population. TUPY-S is ready to be evaluated for its effectiveness among early adolescents. PMID:28612599

Application of quantitative microbial risk assessments for estimation of risk management metrics: Clostridium perfringens in ready-to-eat and partially cooked meat and poultry products as an example.

PubMed

Crouch, Edmund A; Labarre, David; Golden, Neal J; Kause, Janell R; Dearfield, Kerry L

2009-10-01

The U.S. Department of Agriculture, Food Safety and Inspection Service is exploring quantitative risk assessment methodologies to incorporate the use of the Codex Alimentarius' newly adopted risk management metrics (e.g., food safety objectives and performance objectives). It is suggested that use of these metrics would more closely tie the results of quantitative microbial risk assessments (QMRAs) to public health outcomes. By estimating the food safety objective (the maximum frequency and/or concentration of a hazard in a food at the time of consumption) and the performance objective (the maximum frequency and/or concentration of a hazard in a food at a specified step in the food chain before the time of consumption), risk managers will have a better understanding of the appropriate level of protection (ALOP) from microbial hazards for public health protection. We here demonstrate a general methodology that allows identification of an ALOP and evaluation of corresponding metrics at appropriate points in the food chain. It requires a two-dimensional probabilistic risk assessment, the example used being the Monte Carlo QMRA for Clostridium perfringens in ready-to eat and partially cooked meat and poultry products, with minor modifications to evaluate and abstract required measures. For demonstration purposes, the QMRA model was applied specifically to hot dogs produced and consumed in the United States. Evaluation of the cumulative uncertainty distribution for illness rate allows a specification of an ALOP that, with defined confidence, corresponds to current industry practices.

SU-E-J-178: Development of Image Planning System for Radiation Therapy.

PubMed

Thapa, B; Molloy, J

2012-06-01

The constraints required for patient imaging dose received during image-guided radiotherapy differ from those applied in the diagnostic realm. Wide latitude in applied dose can be justified if it results in useful improvement in image quality. Currently, image acquisition parameters are chosen via broad categorizations in patient anatomy and imaging goal. Herein, we describe the development and early benchmarking of a patient-specific image planning system that is capable of predetermining the optimal acquisition parameters for a given level of patient dose and imaging goal. An algorithm was written in Matlab that performed a divergent ray-trace through a 3D CT data set and impinges on a flat imaging receptor. Energy-specific attenuation through each voxel of the CT data set is calculated to derive a net transmitted intensity. The detector response as a function of beam quality and exposure was measured and integrated into the algorithm. It is primarily this feature that distinguishes this from a traditional digitally reconstructed radiograph. Verification data was collected using a flat panel imager mounted onto a linear accelerator gantry and a lung phantom with an embedded nodule. Loss of object detectability was evaluated by measuring the visible diameter of the phantom nodule. There is qualitative agreement between simulated and measured images in terms of contrast and object detectability. The simulation algorithm predicts both under-exposure and saturation of the detector over a range of beam qualities (80 keV to 120keV) and exposure levels. Object detectability erodes predictably above 60 mAs for at 80keV and above 15mAs for 120 keV for both simulated and measured images. Quantitative accuracy is currently limited by lack of beam heterogeneity, which will be added in further work. The feasibility and qualitative accuracy of an image planning system has been established. © 2012 American Association of Physicists in Medicine.

Uncertainty factors in screening ecological risk assessments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duke, L.D.; Taggart, M.

2000-06-01

The hazard quotient (HQ) method is commonly used in screening ecological risk assessments (ERAs) to estimate risk to wildlife at contaminated sites. Many ERAs use uncertainty factors (UFs) in the HQ calculation to incorporate uncertainty associated with predicting wildlife responses to contaminant exposure using laboratory toxicity data. The overall objective was to evaluate the current UF methodology as applied to screening ERAs in California, USA. Specific objectives included characterizing current UF methodology, evaluating the degree of conservatism in UFs as applied, and identifying limitations to the current approach. Twenty-four of 29 evaluated ERAs used the HQ approach: 23 of thesemore » used UFs in the HQ calculation. All 24 made interspecies extrapolations, and 21 compensated for its uncertainty, most using allometric adjustments and some using RFs. Most also incorporated uncertainty for same-species extrapolations. Twenty-one ERAs used UFs extrapolating from lowest observed adverse effect level (LOAEL) to no observed adverse effect level (NOAEL), and 18 used UFs extrapolating from subchronic to chronic exposure. Values and application of all UF types were inconsistent. Maximum cumulative UFs ranged from 10 to 3,000. Results suggest UF methodology is widely used but inconsistently applied and is not uniformly conservative relative to UFs recommended in regulatory guidelines and academic literature. The method is limited by lack of consensus among scientists, regulators, and practitioners about magnitudes, types, and conceptual underpinnings of the UF methodology.« less

Metal-air battery research and development

NASA Astrophysics Data System (ADS)

Behrin, E.; Cooper, J. F.

1982-05-01

This report summarizes the activities of the Metal-air Battery Program during the calendar year 1981. The principal objective is to develop a refuelable battery as an automotive energy source for general-purpose electric vehicles and to conduct engineering demonstrations of its ability to provide vehicles with the range, acceleration, and rapid refueling capability of current internal-combustion-engine automobiles. The second objective is to develop an electrically-rechargeable battery for specific-mission electric vehicles, such as commuter vehicles, that can provide low-cost transportation. The development progression is to: (1) develop a mechanically rechargeable aluminum-air power cell using model electrodes, (2) develop cost-effective anode and cathode materials and structures as required to achieve reliability and efficiency goals, and to establish the economic competitiveness of this technology, and (3) develop and integrated propulsion system utilizing the power cell.

[Objectives and limits of test standards].

PubMed

Kaddick, C; Blömer, W

2014-06-01

Test standards are developed worldwide by extremely committed expert groups working mostly in an honorary capacity and have substantially contributed to the currently achieved safety standards in reconstructive orthopedics. Independent of the distribution and quality of a test specification, the specialist knowledge of the user cannot replace a well founded risk analysis and if used unthinkingly can lead to a false estimation of safety. The limits of standardization are reached where new indications or highly innovative products are concerned. In this case the manufacturer must undertake the time and cost-intensive route of a self-developed testing procedure which in the ideal case leads to a further testing standard. Test standards make a substantial contribution to implant safety but cannot replace the expert knowledge of the user. Tests as an end to themselves take the actual objectives of standardization to absurdity.

Polarimetric passive millimeter-wave sensing

NASA Astrophysics Data System (ADS)

Wikner, David A.; Samples, Greg

2001-08-01

The US Army Research Laboratory has developed a 93-Ghz Stokes radiometer that is currently being used to quantify the polarimetric signature of various objects and materials. Preliminary measurement using the radiometer have been made of various terrain types and objects, which have included an asphalt aircraft runway, a gravel road, water, grass a tank, and a truck. A description of the development of the radiometer, its performance, and some initial results are presented. These results are the first step in assessing the utility of polarimetric radiometry and specifically how missions can be enhanced using this information. The results show that polarimetric radiometry may be useful for eliminating water as a false target in the imagery. It is also shown that asphalt aircraft runways do have a polarimetric signature that is different than short dormant grass at a 3-deg glide slope angle.

The Generalized Support Software (GSS) Domain Engineering Process: An Object-Oriented Implementation and Reuse Success at Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Condon, Steven; Hendrick, Robert; Stark, Michael E.; Steger, Warren

1997-01-01

The Flight Dynamics Division (FDD) of NASA's Goddard Space Flight Center (GSFC) recently embarked on a far-reaching revision of its process for developing and maintaining satellite support software. The new process relies on an object-oriented software development method supported by a domain specific library of generalized components. This Generalized Support Software (GSS) Domain Engineering Process is currently in use at the NASA GSFC Software Engineering Laboratory (SEL). The key facets of the GSS process are (1) an architecture for rapid deployment of FDD applications, (2) a reuse asset library for FDD classes, and (3) a paradigm shift from developing software to configuring software for mission support. This paper describes the GSS architecture and process, results of fielding the first applications, lessons learned, and future directions

The production and quality of tomato concentrates.

PubMed

Hayes, W A; Smith, P G; Morris, A E

1998-10-01

The standards and specifications for the quality and composition of tomato concentrates are reviewed. The main quality parameters of tomato puree and paste are color, consistency and flavor. Overall, there is an absence of standardization of methods and instruments to define quality. While color can now be measured objectively, there are currently no standard color requirements for tomato concentrates. Rheological measurements on both tomato juice and concentrates are reviewed; the power law finds wide applicability, although other rheological characteristics, particularly time dependency, have received far less attention and there has been little effort to relate rheological understanding to the commonly used empirical tests such as consistency measurements. The volatiles responsible for flavor and odor have been identified to the point where the natural odor of tomato paste can be imitated. Attempts to develop objective methods as a substitute for sensory assessment are reviewed.

The relationship between color-object associations and color preference: further investigation of ecological valence theory.

PubMed

Taylor, Chloe; Franklin, Anna

2012-04-01

Ecological valence theory (EVT; Palmer & Schloss, Proceedings of the National Academy of Sciences 107:8877-8882, 2010) proposes that color preferences are due to affective responses to color-associated objects: That is, people generally like colors to the degree that they like the objects associated with those colors. Palmer and Schloss found that the average valence of objects associated with a color, when weighted by how well the objects matched the color (weighted affective valence estimates: WAVE) explained 80% of the variation in preference across colors. Here, we replicated and extended Palmer and Schloss's investigation to establish whether color-object associations can account for sex differences in color preference and whether the relationship between associated objects and color preference is equally strong for males and females. We found some degree of sex specificity to the WAVEs, but the relationship between WAVE and color preference was significantly stronger for males than for females (74% shared variance for males, 45% for females). Furthermore, analyses identified a significant inverse relationship between the number of objects associated with a color and preference for the color. Participants generally liked colors associated with few objects and disliked colors associated with many objects. For the sample overall and for females alone, this association was not significantly weaker than the association of the WAVE and preference. The success of the WAVE at capturing color preference was partly due to the relationship between the number of associated objects and color preference. The findings identify constraints of EVT in its current form, but they also provide general support for the link between color preference and color-object associations.

Community-based pilot intervention to tackle childhood obesity: a whole-system approach.

PubMed

Vamos, E P; Lewis, E; Junghans, C; Hrobonova, E; Dunsford, E; Millett, C

2016-11-01

Go-Golborne is a pilot intervention to prevent childhood obesity in the Royal Borough of Kensington and Chelsea between 2014 and 2018. It is a multistrategy approach targeting children aged 0-16 years and their families in all settings where children live, learn and play. This paper describes the methodology and the practical steps in the development of Go-Golborne. The programme uses a quasi-experimental design for the evaluation of changes in weight status using data from the extended National Child Measurement Programme across local schools. For specific behavioural change objectives, baseline self-reported lifestyle measures will be compared against annual follow-up data over the 3-year study period. Qualitative methods will be used to explore the perceptions of stakeholders and participants and organizational change. Go-Golborne aims to mobilize everyone in the community who has a role or interest in shaping the local environment, norms and behaviours across a range of sectors. A community network of local organizations has been established to codesign all programme activities. The Steering Group of Council officers support programme implementation and environmental changes. The programme has identified six specific behaviour change objectives representing the key areas of need in Golborne and all activities in the council and the community target these objectives during specific programme phases. Key components include community capacity building, community-wide social marketing, environment and policy change and evaluation. The programme is currently at the beginning of its implementation phase with activities in the community and council targeting the first behaviour change objective. The pilot aims to test the effectiveness of this approach to support behaviour change and prevent unhealthy weight gain in children using multiple strategies. This programme will inform the development of an intervention model that defines essential programme components, accountability of partner organizations delivering obesity prevention programmes and the effective use of existing assets. Copyright © 2016 The Royal Society for Public Health. All rights reserved.

The origins of metamodality in visual object area LO: Bodily topographical biases and increased functional connectivity to S1

PubMed Central

Tal, Zohar; Geva, Ran; Amedi, Amir

2016-01-01

Recent evidence from blind participants suggests that visual areas are task-oriented and sensory modality input independent rather than sensory-specific to vision. Specifically, visual areas are thought to retain their functional selectivity when using non-visual inputs (touch or sound) even without having any visual experience. However, this theory is still controversial since it is not clear whether this also characterizes the sighted brain, and whether the reported results in the sighted reflect basic fundamental a-modal processes or are an epiphenomenon to a large extent. In the current study, we addressed these questions using a series of fMRI experiments aimed to explore visual cortex responses to passive touch on various body parts and the coupling between the parietal and visual cortices as manifested by functional connectivity. We show that passive touch robustly activated the object selective parts of the lateral–occipital (LO) cortex while deactivating almost all other occipital–retinotopic-areas. Furthermore, passive touch responses in the visual cortex were specific to hand and upper trunk stimulations. Psychophysiological interaction (PPI) analysis suggests that LO is functionally connected to the hand area in the primary somatosensory homunculus (S1), during hand and shoulder stimulations but not to any of the other body parts. We suggest that LO is a fundamental hub that serves as a node between visual-object selective areas and S1 hand representation, probably due to the critical evolutionary role of touch in object recognition and manipulation. These results might also point to a more general principle suggesting that recruitment or deactivation of the visual cortex by other sensory input depends on the ecological relevance of the information conveyed by this input to the task/computations carried out by each area or network. This is likely to rely on the unique and differential pattern of connectivity for each visual area with the rest of the brain. PMID:26673114

Development of a Decision Support Model for Screening Attention-deficit Hyperactivity Disorder with Actigraph-based Measurements of Classroom Activity

PubMed Central

Kam, H.J.; Shin, Y.M.; Cho, S.M.; Kim, S.Y.; Kim, K.W.; Park, R.W.

2010-01-01

Objective Questionnaire-based ADHD screening tests may not always be objective or accurate, owing to both subjectivity and prejudice. Despite attempts to develop objective measures to characterize ADHD, no widely applicable index currently exists. The principal aim of this study was to develop a decision support model for ADHD screening by monitoring children’s school activities using a 3-axial actigraph. Methods Actigraphs were placed on the non-dominant wrists of 153 children for 3 hours, while they were at school. Children who scored high on the questionnaires were clinically examined by child psychiatrists, who then confirmed ADHD. Mean, variance, and ratios of low-level (0.5-1.0G) and high-level (1.6-3.2G) activity were extracted as activity features from 142 children (10 ADHD, 132 non-ADHD). Two decision-tree models were constructed using the C5.0 algorithm: [A] from whole hours (class + playtime) and [B] during classes. Accuracy, sensitivity, and specificity were evaluated. PPV, NPV, likelihood ratio, and AUC were also calculated for evaluation. Results [Model A] One child without ADHD was misclassified, resulting in an accuracy score of 99.30%. Sensitivity and NPV were 1.0000. Specificity and PPV were 0.992 and 0.803-0.909, respectively. [Model B] Two children without ADHD were misclassified, resulting in an accuracy score of 98.59%. Specificity and PPV were scored at 0.985 and 0.671-0.832, respectively. Conclusion The selected features were consistent with the findings of previous studies. Objective screening of latent patients with ADHD can be accomplished with a simple watch-like sensor, which is worn for just a few hours while the child attends school. The model proposed herein can be applied to a great many children without heavy cost in time and manpower cost, and would generate valuable results from a public health perspective. PMID:23616848

Magnetic Field of Conductive Objects as Superposition of Elementary Eddy Currents and Eddy Current Tomography

NASA Astrophysics Data System (ADS)

Sukhanov, D. Ya.; Zav'yalova, K. V.

2018-03-01

The paper represents induced currents in an electrically conductive object as a totality of elementary eddy currents. The proposed scanning method includes measurements of only one component of the secondary magnetic field. Reconstruction of the current distribution is performed by deconvolution with regularization. Numerical modeling supported by the field experiments show that this approach is of direct practical relevance.

Detecting European Rabbit ( Oryctolagus cuniculus) Disease Outbreaks by Monitoring Digital Media.

PubMed

Peacock, David E; Grillo, Tiggy L

2018-04-18

  Digital media and digital search tools offer simple and effective means to monitor for pathogens and disease outbreaks in target organisms. Using tools such as Rich Site Summary feeds, and Google News and Google Scholar specific key word searches, international digital media were actively monitored from 2012 to 2016 for pathogens and disease outbreaks in the taxonomic order Lagomorpha, with a specific focus on the European rabbit ( Oryctolagus cuniculus). The primary objective was identifying pathogens for assessment as potential new biocontrol agents for Australia's pest populations of the European rabbit. A number of pathogens were detected in digital media reports. Additional benefits arose in the regular provision of case reports and research on myxomatosis and rabbit haemorrhagic disease virus that assisted with current research.

Numerical Simulation of Metallic Uranium Sintering

NASA Astrophysics Data System (ADS)

Berry, Bruce

Conventional ceramic oxide nuclear fuels are limited in their thermal and life-cycle properties. The desire to operate at higher burnups as is required by current utility economics has proven a formidable challenge for oxide fuel designs. Metallic formulations have superior thermal performance but are plagued by volumetric swelling due to fission gas buildup. In this study, we consider a number of specific microstructure configurations that have been experimentally shown to exhibit considerable resistance to porosity loss. Specifically, a void sizing that is bimodally distributed was shown to resist early pore loss and could provide collection sites for fission gas buildup. We employ the phase field model of Cahn and Hilliard, solved via the finite element method using the open source Multi-User Object Oriented Simulation Environment (MOOSE) developed by INL.

Space Shuttle SRM development. [Solid Rocket Motors

NASA Technical Reports Server (NTRS)

Brinton, B. C.; Kilminster, J. C.

1979-01-01

The successful static test of the fourth Development Space Shuttle Solid Rocket Motor (SRM) in February 1979 concluded the development testing phase of the SRM Project. Qualification and flight motors are currently being fabricated, with the first qualification motor to be static tested. Delivered thrust-time traces on all development motors were very close to predicted values, and both specific and total impulse exceeded specification requirements. 'All-up' static tests conducted with a solid rocket booster equipment on development motors achieved all test objectives. Transportation and support equipment concepts have been proven, baselining is complete, and component reusability has been demonstrated. Evolution of the SRM transportation support equipment, and special test equipment designs are reviewed, and development activities discussed. Handling and processing aspects of large, heavy components are described.

Object Agreement and Specificity in Early Swahili

ERIC Educational Resources Information Center

Deen, Kamil Ud

2006-01-01

Schaeffer (1997, 2000) argues that children lack knowledge of specificity because Dutch children omit determiners and fail to scramble pronouns. Avrutin & Brun (2001), however, find that Russian children place arguments correctly according to whether they are specific or non-specific. This paper investigates object agreement and specificity in…

Aeronautics Research and Technology Program and specific objectives, fiscal year 1982

NASA Technical Reports Server (NTRS)

Olstad, W. B.

1981-01-01

The Aeronautics Research and Technology program is broken down into two program areas (research and technology base, and systems technology programs) which are further broken down into succeedingly more detailed activities to form a work breakdown structure for the aeronautics program: program area, program/discipline objective, specific objective, and research and technology objective and plan (RTOP). A detailed view of this work breakdown structure down to the specific objective level is provided, and goals or objectives at each of these levels are set forth. What is to be accomplished and why are addressed, but not how. The letter falls within the domain of the RTOP.

Conservation planning under uncertainty in urban development and vegetation dynamics

PubMed Central

Carmel, Yohay

2018-01-01

Systematic conservation planning is a framework for optimally locating and prioritizing areas for conservation. An often-noted shortcoming of most conservation planning studies is that they do not address future uncertainty. The selection of protected areas that are intended to ensure the long-term persistence of biodiversity is often based on a snapshot of the current situation, ignoring processes such as climate change. Scenarios, in the sense of being accounts of plausible futures, can be utilized to identify conservation area portfolios that are robust to future uncertainty. We compared three approaches for utilizing scenarios in conservation area selection: considering a full set of scenarios (all-scenarios portfolio), assuming the realization of specific scenarios, and a reference strategy based on the current situation (current distributions portfolio). Our objective was to compare the robustness of these approaches in terms of their relative performance across future scenarios. We focused on breeding bird species in Israel’s Mediterranean region. We simulated urban development and vegetation dynamics scenarios 60 years into the future using DINAMICA-EGO, a cellular-automata simulation model. For each scenario, we mapped the target species’ available habitat distribution, identified conservation priority areas using the site-selection software MARXAN, and constructed conservation area portfolios using the three aforementioned strategies. We then assessed portfolio performance based on the number of species for which representation targets were met in each scenario. The all-scenarios portfolio consistently outperformed the other portfolios, and was more robust to ‘errors’ (e.g., when an assumed specific scenario did not occur). On average, the all-scenarios portfolio achieved representation targets for five additional species compared with the current distributions portfolio (approximately 33 versus 28 species). Our findings highlight the importance of considering a broad and meaningful set of scenarios, rather than relying on the current situation, the expected occurrence of specific scenarios, or the worst-case scenario. PMID:29621330

Conservation planning under uncertainty in urban development and vegetation dynamics.

PubMed

Troupin, David; Carmel, Yohay

2018-01-01

Systematic conservation planning is a framework for optimally locating and prioritizing areas for conservation. An often-noted shortcoming of most conservation planning studies is that they do not address future uncertainty. The selection of protected areas that are intended to ensure the long-term persistence of biodiversity is often based on a snapshot of the current situation, ignoring processes such as climate change. Scenarios, in the sense of being accounts of plausible futures, can be utilized to identify conservation area portfolios that are robust to future uncertainty. We compared three approaches for utilizing scenarios in conservation area selection: considering a full set of scenarios (all-scenarios portfolio), assuming the realization of specific scenarios, and a reference strategy based on the current situation (current distributions portfolio). Our objective was to compare the robustness of these approaches in terms of their relative performance across future scenarios. We focused on breeding bird species in Israel's Mediterranean region. We simulated urban development and vegetation dynamics scenarios 60 years into the future using DINAMICA-EGO, a cellular-automata simulation model. For each scenario, we mapped the target species' available habitat distribution, identified conservation priority areas using the site-selection software MARXAN, and constructed conservation area portfolios using the three aforementioned strategies. We then assessed portfolio performance based on the number of species for which representation targets were met in each scenario. The all-scenarios portfolio consistently outperformed the other portfolios, and was more robust to 'errors' (e.g., when an assumed specific scenario did not occur). On average, the all-scenarios portfolio achieved representation targets for five additional species compared with the current distributions portfolio (approximately 33 versus 28 species). Our findings highlight the importance of considering a broad and meaningful set of scenarios, rather than relying on the current situation, the expected occurrence of specific scenarios, or the worst-case scenario.

Evaluation and prioritization of stream habitat monitoring in the Lower Columbia Salmon and Steelhead Recovery Domain as related to the habitat monitoring needs of ESA recovery plans

USGS Publications Warehouse

Puls, Amy L.; Anlauf Dunn, Kara; Graham Hudson, Bernadette

2014-01-01

The lower Columbia River and its tributaries once supported abundant runs of salmon and steelhead; however, there are five species currently listed under the federal Endangered Species Act (ESA). The National Marine Fisheries Service has completed, and is proposing for adoption, a comprehensive ESA Recovery Plan for the Lower Columbia Evolutionarily Significant Units (ESUs) based on the recovery plans developed by Oregon and Washington. One of the primary factors attributed to the decline of these species is habitat degradation. There are numerous entities conducting status and/or trends monitoring of instream habitat in the lower Columbia River Basin, but because the programs were developed for agency specific reasons, the existing monitoring efforts are not well coordinated, and often lack the spatial coverage, certainty, or species coverage necessary to answer questions related to status and trends of the ESA listed populations. The Pacific Northwest Aquatic Monitoring Partnership’s Integrated Status and Trends Monitoring (ISTM) project was initiated to improve integration of existing and new monitoring efforts by developing recommendations for sampling frames, protocols, and data sharing. In an effort to meet the ISTM project goals, five objectives were identified: (1) identify and prioritize decisions, questions, and monitoring objectives, (2) evaluate how existing programs align with these management decisions, questions, and objectives, (3) identify the most appropriate monitoring design to inform priority management decisions, questions, and objectives, (4) use trade-off analysis to develop specific recommendations for monitoring based on outcomes of Objectives 1-3 and (5) recommend implementation and reporting mechanisms. This report summarizes the effort to address Objectives 1 and 2, detailing the commonalities among the habitat characteristics that all entities measure and monitor, and how the metrics align with the priorities listed in the comprehensive recovery plan for the Lower Columbia ESUs.

Statistical Learning Is Constrained to Less Abstract Patterns in Complex Sensory Input (but not the Least)

PubMed Central

Emberson, Lauren L.; Rubinstein, Dani

2016-01-01

The influence of statistical information on behavior (either through learning or adaptation) is quickly becoming foundational to many domains of cognitive psychology and cognitive neuroscience, from language comprehension to visual development. We investigate a central problem impacting these diverse fields: when encountering input with rich statistical information, are there any constraints on learning? This paper examines learning outcomes when adult learners are given statistical information across multiple levels of abstraction simultaneously: from abstract, semantic categories of everyday objects to individual viewpoints on these objects. After revealing statistical learning of abstract, semantic categories with scrambled individual exemplars (Exp. 1), participants viewed pictures where the categories as well as the individual objects predicted picture order (e.g., bird1—dog1, bird2—dog2). Our findings suggest that participants preferentially encode the relationships between the individual objects, even in the presence of statistical regularities linking semantic categories (Exps. 2 and 3). In a final experiment we investigate whether learners are biased towards learning object-level regularities or simply construct the most detailed model given the data (and therefore best able to predict the specifics of the upcoming stimulus) by investigating whether participants preferentially learn from the statistical regularities linking individual snapshots of objects or the relationship between the objects themselves (e.g., bird_picture1— dog_picture1, bird_picture2—dog_picture2). We find that participants fail to learn the relationships between individual snapshots, suggesting a bias towards object-level statistical regularities as opposed to merely constructing the most complete model of the input. This work moves beyond the previous existence proofs that statistical learning is possible at both very high and very low levels of abstraction (categories vs. individual objects) and suggests that, at least with the current categories and type of learner, there are biases to pick up on statistical regularities between individual objects even when robust statistical information is present at other levels of abstraction. These findings speak directly to emerging theories about how systems supporting statistical learning and prediction operate in our structure-rich environments. Moreover, the theoretical implications of the current work across multiple domains of study is already clear: statistical learning cannot be assumed to be unconstrained even if statistical learning has previously been established at a given level of abstraction when that information is presented in isolation. PMID:27139779

Attribute-based classification for zero-shot visual object categorization.

PubMed

Lampert, Christoph H; Nickisch, Hannes; Harmeling, Stefan

2014-03-01

We study the problem of object recognition for categories for which we have no training examples, a task also called zero--data or zero-shot learning. This situation has hardly been studied in computer vision research, even though it occurs frequently; the world contains tens of thousands of different object classes, and image collections have been formed and suitably annotated for only a few of them. To tackle the problem, we introduce attribute-based classification: Objects are identified based on a high-level description that is phrased in terms of semantic attributes, such as the object's color or shape. Because the identification of each such property transcends the specific learning task at hand, the attribute classifiers can be prelearned independently, for example, from existing image data sets unrelated to the current task. Afterward, new classes can be detected based on their attribute representation, without the need for a new training phase. In this paper, we also introduce a new data set, Animals with Attributes, of over 30,000 images of 50 animal classes, annotated with 85 semantic attributes. Extensive experiments on this and two more data sets show that attribute-based classification indeed is able to categorize images without access to any training images of the target classes.

Planning for the semiconductor manufacturer of the future

NASA Technical Reports Server (NTRS)

Fargher, Hugh E.; Smith, Richard A.

1992-01-01

Texas Instruments (TI) is currently contracted by the Air Force Wright Laboratory and the Defense Advanced Research Projects Agency (DARPA) to develop the next generation flexible semiconductor wafer fabrication system called Microelectronics Manufacturing Science & Technology (MMST). Several revolutionary concepts are being pioneered on MMST, including the following: new single-wafer rapid thermal processes, in-situ sensors, cluster equipment, and advanced Computer Integrated Manufacturing (CIM) software. The objective of the project is to develop a manufacturing system capable of achieving an order of magnitude improvement in almost all aspects of wafer fabrication. TI was awarded the contract in Oct., 1988, and will complete development with a fabrication facility demonstration in April, 1993. An important part of MMST is development of the CIM environment responsible for coordinating all parts of the system. The CIM architecture being developed is based on a distributed object oriented framework made of several cooperating subsystems. The software subsystems include the following: process control for dynamic control of factory processes; modular processing system for controlling the processing equipment; generic equipment model which provides an interface between processing equipment and the rest of the factory; specification system which maintains factory documents and product specifications; simulator for modelling the factory for analysis purposes; scheduler for scheduling work on the factory floor; and the planner for planning and monitoring of orders within the factory. This paper first outlines the division of responsibility between the planner, scheduler, and simulator subsystems. It then describes the approach to incremental planning and the way in which uncertainty is modelled within the plan representation. Finally, current status and initial results are described.

Programmable colloidal molecules from sequential capillarity-assisted particle assembly

PubMed Central

Ni, Songbo; Leemann, Jessica; Buttinoni, Ivo; Isa, Lucio; Wolf, Heiko

2016-01-01

The assembly of artificial nanostructured and microstructured materials which display structures and functionalities that mimic nature’s complexity requires building blocks with specific and directional interactions, analogous to those displayed at the molecular level. Despite remarkable progress in synthesizing “patchy” particles encoding anisotropic interactions, most current methods are restricted to integrating up to two compositional patches on a single “molecule” and to objects with simple shapes. Currently, decoupling functionality and shape to achieve full compositional and geometrical programmability remains an elusive task. We use sequential capillarity-assisted particle assembly which uniquely fulfills the demands described above. This is a new method based on simple, yet essential, adaptations to the well-known capillary assembly of particles over topographical templates. Tuning the depth of the assembly sites (traps) and the surface tension of moving droplets of colloidal suspensions enables controlled stepwise filling of traps to “synthesize” colloidal molecules. After deposition and mechanical linkage, the colloidal molecules can be dispersed in a solvent. The template’s shape solely controls the molecule’s geometry, whereas the filling sequence independently determines its composition. No specific surface chemistry is required, and multifunctional molecules with organic and inorganic moieties can be fabricated. We demonstrate the “synthesis” of a library of structures, ranging from dumbbells and triangles to units resembling bar codes, block copolymers, surfactants, and three-dimensional chiral objects. The full programmability of our approach opens up new directions not only for assembling and studying complex materials with single-particle-level control but also for fabricating new microscale devices for sensing, patterning, and delivery applications. PMID:27051882

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahesh, M; Borras, C; Frey, G

This workshop is jointly organized by the AAPM, the Spanish (SEFM) and the Russian (AMPR) Medical Physics Societies, as part of formal educational exchange agreements signed by the AAPM with each one of these two societies.With the rapid technological advances in radiation therapy both for treatment and imaging, it is challenging how physics is taught to medical physicists practicing in radiation therapy. The main Objectives: of this workshop is to bring forth current status, challenges and issues related to education of radiation therapy physicists here in the US, Spain and Russia. Medical physicists from each one of these countries willmore » present educational requirements of international recommendations and directives and analyze their impact on national legislations. Current and future educational models and plans for harmonization will be described. The role of universities, professional societies and examination boards, such as the American Board of Radiology, will be discussed. Minimum standards will be agreed upon. Learning Objectives: Review medical physics educational models supported by AAPM, SEFM, and AMPR. Discuss the role of governmental and non-governmental organizations in elaborating and adopting medical physics syllabi. Debate minimum educational standards for medical physics education based on country-specific resources.« less

Dynamic Model Predicting Overweight, Obesity, and Extreme Obesity Prevalence Trends

PubMed Central

Thomas, Diana M.; Weedermann, Marion; Fuemmeler, Bernard F.; Martin, Corby K.; Dhurandhar, Nikhil V.; Bredlau, Carl; Heymsfield, Steven B.; Ravussin, Eric; Bouchard, Claude

2013-01-01

Objective Obesity prevalence in the United States (US) appears to be leveling, but the reasons behind the plateau remain unknown. Mechanistic insights can be provided from a mathematical model. The objective of this study is to model known multiple population parameters associated with changes in body mass index (BMI) classes and to establish conditions under which obesity prevalence will plateau. Design and Methods A differential equation system was developed that predicts population-wide obesity prevalence trends. The model considers both social and non-social influences on weight gain, incorporates other known parameters affecting obesity trends, and allows for country specific population growth. Results The dynamic model predicts that: obesity prevalence is a function of birth rate and the probability of being born in an obesogenic environment; obesity prevalence will plateau independent of current prevention strategies; and the US prevalence of obesity, overweight, and extreme obesity will plateau by about 2030 at 28%, 32%, and 9%, respectively. Conclusions The US prevalence of obesity is stabilizing and will plateau, independent of current preventative strategies. This trend has important implications in accurately evaluating the impact of various anti-obesity strategies aimed at reducing obesity prevalence. PMID:23804487

Modular techniques for dynamic fault-tree analysis

NASA Technical Reports Server (NTRS)

Patterson-Hine, F. A.; Dugan, Joanne B.

1992-01-01

It is noted that current approaches used to assess the dependability of complex systems such as Space Station Freedom and the Air Traffic Control System are incapable of handling the size and complexity of these highly integrated designs. A novel technique for modeling such systems which is built upon current techniques in Markov theory and combinatorial analysis is described. It enables the development of a hierarchical representation of system behavior which is more flexible than either technique alone. A solution strategy which is based on an object-oriented approach to model representation and evaluation is discussed. The technique is virtually transparent to the user since the fault tree models can be built graphically and the objects defined automatically. The tree modularization procedure allows the two model types, Markov and combinatoric, to coexist and does not require that the entire fault tree be translated to a Markov chain for evaluation. This effectively reduces the size of the Markov chain required and enables solutions with less truncation, making analysis of longer mission times possible. Using the fault-tolerant parallel processor as an example, a model is built and solved for a specific mission scenario and the solution approach is illustrated in detail.

Geo-Information Technology of 8-Level Responsibility: Concept and Standard of Construction Management for Implementation of The BIM-Technology in Russia

NASA Astrophysics Data System (ADS)

Komosko, Vladimir; Serebryakov, Sergey; Strokov, Vladimir

2017-12-01

Currently, the increase in construction efficiency in the world is associated with the introduction and development of information modelling of construction objects (BIM-technology). The BIM-technology is a process of collective creation and use of information about a structure that forms the basis for all decisions throughout the life cycle of an object. The BIM-technology with the help of a number of software products provides automation of production, it does not provide a methodology for the introduction of these products. The article describes the technology of 8-level responsibility, which is guaranteed to give systematically a new quality of management in construction, related to the requirements of the Russian Government Decree No. 87 of February 16, 2008. The technology of 8-level responsibility (8LR) in the detailed specification of GD No. 87, (territory, construction stage, master plan object, section (part) of the project) extends the number of inseparable levels to 8 (part of the object, element, mark, position), where the “position” is the last indivisible detail of the object. There is reason to argue that the use of the “8LR Technology” in addition to the BIM-technology will provide a synergistic effect and will remove a number of obstacles to the BIM introduction in Russia and system control in the construction and operation of objects of any complexity in Russia.

Object Oriented Programming Systems (OOPS) and frame representations: An investigation of programming paradigms

NASA Technical Reports Server (NTRS)

Auty, David

1988-01-01

The project was initiated to research Object Oriented Programming Systems (OOPS) and frame representation systems, their significance and applicability, and their implementation in or relationship to Ada. Object orientated is currently a very popular conceptual adjective. Object oriented programming, in particular, is promoted as a particularly productive approach to programming; an approach which maximizes opportunities for code reuse and lends itself to the definition of convenient and well-developed units. Such units are thus expected to be usable in a variety of situations, beyond the typical highly specific unit development of other approaches. Frame represenation systems share a common heritage and similar conceptual foundations. Together they represent a quickly emerging alternative approach to programming. The approach is to first define the terms, starting with relevant concepts and using these to put bounds on what is meant by OOPS and Frames. From this the possibilities were pursued to merge OOPS with Ada which will further elucidate the significant characteristics which make up this programming approach. Finally, some of the merits and demerits of OOPS were briefly considered as a way of addressing the applicability of OOPS to various programming tasks.

Effect of aging on dynamic postural stability and variability during a multi-directional lean and reach object transportation task.

PubMed

Huntley, Andrew H; Zettel, John L; Vallis, Lori Ann

2016-01-01

A "reach and transport object" task that represents common activities of daily living may provide improved insight into dynamic postural stability and movement variability deficits in older adults compared to previous lean to reach and functional reach tests. Healthy young and older, community dwelling adults performed three same elevation object transport tasks and two multiple elevation object transport tasks under two self-selected speeds, self-paced and fast-paced. Dynamic postural stability and movement variability was quantified by whole-body center of mass motion. Older adults demonstrated significant decrements in frontal plane stability during the multiple elevation tasks while exhibiting the same movement variability as their younger counterparts, regardless of task speed. Interestingly, older adults did not exhibit a tradeoff in maneuverability in favour of maintaining stability throughout the tasks, as has previously been reported. In conclusion, the multi-planar, ecologically relevant tasks employed in the current study were specific enough to elucidate decrements in dynamic stability, and thus may be useful for assessing fall risk in older adults with suspected postural instability. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Biological organization of the extraocular muscles.

PubMed

Spencer, Robert F; Porter, John D

2006-01-01

Extraocular muscle is fundamentally distinct from other skeletal muscles. Here, we review the biological organization of the extraocular muscles with the intent of understanding this novel muscle group in the context of oculomotor system function. The specific objectives of this review are threefold. The first objective is to understand the anatomic arrangement of the extraocular muscles and their compartmental or layered organization in the context of a new concept of orbital mechanics, the active pulley hypothesis. The second objective is to present an integrated view of the morphologic, cellular, and molecular differences between extraocular and the more traditional skeletal muscles. The third objective is to relate recent data from functional and molecular biology studies to the established extraocular muscle fiber types. Developmental mechanisms that may be responsible for the divergence of the eye muscles from a skeletal muscle prototype also are considered. Taken together, a multidisciplinary understanding of extraocular muscle biology in health and disease provides insights into oculomotor system function and malfunction. Moreover, because the eye muscles are selectively involved or spared in a variety of neuromuscular diseases, knowledge of their biology may improve current pathogenic models of and treatments for devastating systemic diseases.

Capaciflector-guided mechanisms

NASA Technical Reports Server (NTRS)

Vranish, John M. (Inventor)

1996-01-01

A plurality of capaciflector proximity sensors, one or more of which may be overlaid on each other, and at least one shield are mounted on a device guided by a robot so as to see a designated surface, hole or raised portion of an object, for example, in three dimensions. Individual current-measuring voltage follower circuits interface the sensors and shield to a common AC signal source. As the device approaches the object, the sensors respond by a change in the currents therethrough. The currents are detected by the respective current-measuring voltage follower circuits with the outputs thereof being fed to a robot controller. The device is caused to move under robot control in a predetermined pattern over the object while directly referencing each other without any offsets, whereupon by a process of minimization of the sensed currents, the device is dithered or wiggled into position for a soft touchdown or contact without any prior contact with the object.

Writing a Research Proposal to The Research Council of Oman

PubMed Central

Al-Shukaili, Ahmed; Al-Maniri, Abdullah

2017-01-01

Writing a research proposal can be a challenging task for young researchers. This article explains how to write a strong research proposal to apply for funding, specifically, a proposal for The Research Council (TRC) of Oman. Three different research proposal application forms are currently used in TRC, including Open Research Grant (ORG), Graduate Research Support Program (GRSP), and Faculty-mentored Undergraduate Research Award Program (FURAP). The application forms are filled and submitted electronically on TRC website. Each of the proposals submitted to TRC is selected through a rigorous reviewing and screening process. Novelty and originality of the research idea is the most crucial element in writing a research proposal. Performing an in-depth review of the literature will assist you to compose a good researchable question and generate a strong hypothesis. The development of a good hypothesis will offer insight into the specific objectives of a study. Research objectives should be focused, measurable, and achievable by a specific time using the most appropriate methodology. Moreover, it is essential to select a proper study design in-line with the purpose of the study and the hypothesis. Furthermore, social/economic impact and reasonable budget of proposed research are important criteria in research proposal evaluation by TRC. Finally, ethical principles should be observed before writing a research proposal involving human or animal subjects. PMID:28584597

Applied Virtual Reality Research and Applications at NASA/Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Hale, Joseph P.

1995-01-01

A Virtual Reality (VR) applications program has been under development at NASA/Marshall Space Flight Center (MSFC) since 1989. The objectives of the MSFC VR Applications Program are to develop, assess, validate, and utilize VR in hardware development, operations development and support, mission operations training and science training. Before this technology can be utilized with confidence in these applications, it must be validated for each particular class of application. That is, the precision and reliability with which it maps onto real settings and scenarios, representative of a class, must be calculated and assessed. The approach of the MSFC VR Applications Program is to develop and validate appropriate virtual environments and associated object kinematic and behavior attributes for specific classes of applications. These application-specific environments and associated simulations will be validated, where possible, through empirical comparisons with existing, accepted tools and methodologies. These validated VR analytical tools will then be available for use in the design and development of space systems and operations and in training and mission support systems. Specific validation studies for selected classes of applications have been completed or are currently underway. These include macro-ergonomic "control-room class" design analysis, Spacelab stowage reconfiguration training, a full-body micro-gravity functional reach simulator, and a gross anatomy teaching simulator. This paper describes the MSFC VR Applications Program and the validation studies.

Electromagnetic fasteners

DOEpatents

Crane, Randolph W.; Marts, Donna J.

1994-11-01

An electromagnetic fastener for manipulating objects in space uses the matic attraction of various metals. An end effector is attached to a robotic manipulating system having an electromagnet such that when current is supplied to the electromagnet, the object is drawn and affixed to the end effector, and when the current is withheld, the object is released. The object to be manipulated includes a multiplicity of ferromagnetic patches at various locations to provide multiple areas for the effector on the manipulator to become affixed to the object. The ferromagnetic patches are sized relative to the object's geometry and mass.

Electromagnetic fasteners

DOEpatents

Crane, Randolph W.; Marts, Donna J.

1994-01-01

An electromagnetic fastener for manipulating objects in space uses the matic attraction of various metals. An end effector is attached to a robotic manipulating system having an electromagnet such that when current is supplied to the electromagnet, the object is drawn and affixed to the end effector, and when the current is withheld, the object is released. The object to be manipulated includes a multiplicity of ferromagnetic patches at various locations to provide multiple areas for the effector on the manipulator to become affixed to the object. The ferromagnetic patches are sized relative to the object's geometry and mass.

Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair

PubMed Central

Mithoefer, Kai; Saris, Daniel B.F.; Farr, Jack; Kon, Elizaveta; Zaslav, Kenneth; Cole, Brian J.; Ranstam, Jonas; Yao, Jian; Shive, Matthew; Levine, David; Dalemans, Wilfried; Brittberg, Mats

2011-01-01

Objective: To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee cartilage repair procedures and products. Design: A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular cartilage repair in the knee. Analysis of cartilage repair publications and synopses of ongoing trials were used to identify important criteria for the design, reporting, and interpretation of studies in this field. Results: Current literature reflects the methodological limitations of the scientific evidence available for articular cartilage repair. However, clinical trial databases of ongoing trials document a trend suggesting improved study designs and clinical evaluation methodology. Based on the current scientific information and standards of clinical care, detailed methodological recommendations were developed for the statistical study design, patient recruitment, control group considerations, study endpoint definition, documentation of results, use of validated patient-reported outcome instruments, and inclusion and exclusion criteria for the design and conduct of scientifically sound cartilage repair study protocols. A consensus statement among the International Cartilage Repair Society (ICRS) and contributing authors experienced in clinical trial design and implementation was achieved. Conclusions: High-quality clinical research methodology is critical for the optimal evaluation of current and new cartilage repair technologies. In addition to generally applicable principles for orthopedic study design, specific criteria and considerations apply to cartilage repair studies. Systematic application of these criteria and considerations can facilitate study designs that are scientifically rigorous, ethical, practical, and appropriate for the question(s) being addressed in any given cartilage repair research project. PMID:26069574

Dynamic Electrothermal Model of a Sputtered Thermopile Thermal Radiation Detector for Earth Radiation Budget Applications

NASA Technical Reports Server (NTRS)

Weckmann, Stephanie

1997-01-01

The Clouds and the Earth's Radiant Energy System (CERES) is a program sponsored by the National Aeronautics and Space Administration (NASA) aimed at evaluating the global energy balance. Current scanning radiometers used for CERES consist of thin-film thermistor bolometers viewing the Earth through a Cassegrain telescope. The Thermal Radiation Group, a laboratory in the Department of Mechanical Engineering at Virginia Polytechnic Institute and State University, is currently studying a new sensor concept to replace the current bolometer: a thermopile thermal radiation detector. This next-generation detector would consist of a thermal sensor array made of thermocouple junction pairs, or thermopiles. The objective of the current research is to perform a thermal analysis of the thermopile. Numerical thermal models are particularly suited to solve problems for which temperature is the dominant mechanism of the operation of the device (through the thermoelectric effect), as well as for complex geometries composed of numerous different materials. Feasibility and design specifications are studied by developing a dynamic electrothermal model of the thermopile using the finite element method. A commercial finite element-modeling package, ALGOR, is used.

If an antelope is a document, then a rock is data: preserving earth science samples for the future

NASA Astrophysics Data System (ADS)

Ramdeen, S.

2015-12-01

As discussed in seminal works by Briet (1951) and Buckland (1998), physical objects can be considered documents when given specific context. In the case of an antelope, in the wild it's an animal, in a zoo it's a document. It is the primary source of information, specifically when it is made an object of study. When discussing earth science data, we may think about numbers in a spreadsheet or verbal descriptions of a rock. But what about physical materials such as cores, cuttings, fossils, and other tangible objects? The most recent version of the American Geophysical Union's data position statement states data preservation and management policies should apply to both "digital data and physical objects"[1]. If an antelope is a document, than isn't a rock a form of data? Like books in a library or items in a museum, these objects require surrogates (digital or analog) that allow researchers to access and retrieve them. Once these scientific objects are acquired, researchers can process the information they contain. Unlike books, and some museum materials, most earth science objects cannot yet be completely replaced by digital surrogates. A fossil may be scanned, but the original is needed for chemical testing and ultimately for 'not yet developed' processes of scientific analysis. These objects along with their metadata or other documentation become scientific data when they are used in research. Without documentation of key information (i.e. the location where it was collected) these objects may lose their scientific value. This creates a complex situation where we must preserve the object, its metadata, and the connection between them. These factors are important as we consider the future of earth science data, our definitions of what constitutes scientific data, as well as our data preservation and management practices. This talk will discuss current initiatives within the earth science communities (EarthCube's EC3 and iSamples; USGS's data preservation program; etc.) and within the communities of information science. As practitioners, these librarians, information scientists, and archivists work on similar issues and can offer practices and theories that might help us 'future proof' physical earth science records. [1] http://sciencepolicy.agu.org/draft-data-position-statement-comment

An Object-Based Approach to Evaluation of Climate Variability Projections and Predictions

NASA Astrophysics Data System (ADS)

Ammann, C. M.; Brown, B.; Kalb, C. P.; Bullock, R.

2017-12-01

Evaluations of the performance of earth system model predictions and projections are of critical importance to enhance usefulness of these products. Such evaluations need to address specific concerns depending on the system and decisions of interest; hence, evaluation tools must be tailored to inform about specific issues. Traditional approaches that summarize grid-based comparisons of analyses and models, or between current and future climate, often do not reveal important information about the models' performance (e.g., spatial or temporal displacements; the reason behind a poor score) and are unable to accommodate these specific information needs. For example, summary statistics such as the correlation coefficient or the mean-squared error provide minimal information to developers, users, and decision makers regarding what is "right" and "wrong" with a model. New spatial and temporal-spatial object-based tools from the field of weather forecast verification (where comparisons typically focus on much finer temporal and spatial scales) have been adapted to more completely answer some of the important earth system model evaluation questions. In particular, the Method for Object-based Diagnostic Evaluation (MODE) tool and its temporal (three-dimensional) extension (MODE-TD) have been adapted for these evaluations. More specifically, these tools can be used to address spatial and temporal displacements in projections of El Nino-related precipitation and/or temperature anomalies, ITCZ-associated precipitation areas, atmospheric rivers, seasonal sea-ice extent, and other features of interest. Examples of several applications of these tools in a climate context will be presented, using output of the CESM large ensemble. In general, these tools provide diagnostic information about model performance - accounting for spatial, temporal, and intensity differences - that cannot be achieved using traditional (scalar) model comparison approaches. Thus, they can provide more meaningful information that can be used in decision-making and planning. Future extensions and applications of these tools in a climate context will be considered.

Objective pain diagnostics: clinical neurophysiology.

PubMed

Garcia-Larrea, L

2012-06-01

Neurophysiological techniques help in diagnosis, prognosis and treatment of chronic pain, and are particularly useful to determine its neuropathic origin. According to current standards, the diagnosis of definite neuropathic pain (NP) needs objective confirmation of a lesion or disease of somatosensory systems, which can be provided by neurophysiological testing. Lesions causing NP mostly concern the pain-temperature pathways, and therefore neurophysiological procedures allowing the specific testing of these pathways (i.e., A-delta and C-fibres, spino-thalamo-cortical tracts) are essential for objective diagnosis. Different techniques to stimulate selectively pain-temperature pathways are discussed. Of these, laser-evoked potentials (LEPs) appear as the easiest and most reliable neurophysiological method of assessing nociceptive function, and their coupling with autonomic responses (e.g., galvanic skin response) and psychophysics (quantitative sensory testing - QST) can still enhance their diagnostic yield. Neurophysiological techniques not exploring specifically nociception, such as standard nerve conduction velocities (NCV) and SEPs to non-noxious stimulation, should be associated to the exploration of nociceptive systems, not only because both may be simultaneously affected to different degrees, but also because some specific painful symptoms, such as paroxysmal discharges, may depend on specific alteration of highly myelinated A-beta fibres. The choice of techniques is determined after anamnesis and clinical exam, and tries to answer a number of questions: (a) is the pain-related to injury of somatosensory pathways?; (b) to what extent are different subsystems affected?; (c) are mechanisms and lesion site in accordance with imaging data?; (d) are results of use for diagnostic or therapeutic follow-up? Neuropathic pain (NP) affects more than 15 million people in Western countries, and its belated diagnosis leads to insufficient or delayed therapy. The use of neurofunctional approaches to obtain a "physiological photograph" of somatosensory function is therefore highly relevant, as it yields significant clues about the type and mechanisms of pain, thus prompting rapid and optimised therapy. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Optimising a curriculum for clinical haematology and biochemistry in sports medicine: a Delphi approach

PubMed Central

Fallon, K E; Trevitt, A C

2006-01-01

Objectives To investigate issues of curriculum in the context of a postgraduate sports medicine training programme, specifically in the field of clinical biochemistry and haematology. Methods Following the Delphi methodology, a series of sequential questionnaires was administered to curriculum developers, clinical teachers, examiners, and registrars. Results Agreement on a core syllabus for this subject with an indication of the core aims and objectives of teaching and learning in this field and the associated required skills and competencies. An indication of current and ideal teaching and learning methods and reasons for these preferences. A consensus of key features of a teaching module for this field and of appropriate methods of examination. Conclusions The data derived from this study, as well as the experience of engaging in it, will better inform curriculum developers, teachers, and students of one another's perceptions as to what is important in and appropriate to teaching and learning in this field of sports medicine. Engagement in the exercise and broader consideration of the outcomes by those who develop the curriculum, teach, and formulate the examination process will facilitate attainment of the ideal of well aligned teaching, learning, and examination in this specific field. PMID:16432001

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

PubMed Central

Bandelow, Borwin; Baldwin, David; Abelli, Marianna; Bolea-Alamanac, Blanca; Bourin, Michel; Chamberlain, Samuel R.; Cinosi, Eduardo; Davies, Simon; Domschke, Katharina; Fineberg, Naomi; Grünblatt, Edna; Jarema, Marek; Kim, Yong-Ku; Maron, Eduard; Masdrakis, Vasileios; Mikova, Olya; Nutt, David; Pallanti, Stefano; Pini, Stefano; Ströhle, Andreas; Thibaut, Florence; Vaghix, Matilde M.; Won, Eunsoo; Wedekind, Dirk; Wichniak, Adam; Woolley, Jade; Zwanzger, Peter; Riederer, Peter

2017-01-01

Objective Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Methods Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network. Results The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO2 hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics. Conclusions Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD. PMID:27419272

Characterizing psychological dimensions in non-pathological subjects through autonomic nervous system dynamics

PubMed Central

Nardelli, Mimma; Valenza, Gaetano; Cristea, Ioana A.; Gentili, Claudio; Cotet, Carmen; David, Daniel; Lanata, Antonio; Scilingo, Enzo P.

2015-01-01

The objective assessment of psychological traits of healthy subjects and psychiatric patients has been growing interest in clinical and bioengineering research fields during the last decade. Several experimental evidences strongly suggest that a link between Autonomic Nervous System (ANS) dynamics and specific dimensions such as anxiety, social phobia, stress, and emotional regulation might exist. Nevertheless, an extensive investigation on a wide range of psycho-cognitive scales and ANS non-invasive markers gathered from standard and non-linear analysis still needs to be addressed. In this study, we analyzed the discerning and correlation capabilities of a comprehensive set of ANS features and psycho-cognitive scales in 29 non-pathological subjects monitored during resting conditions. In particular, the state of the art of standard and non-linear analysis was performed on Heart Rate Variability, InterBreath Interval series, and InterBeat Respiration series, which were considered as monovariate and multivariate measurements. Experimental results show that each ANS feature is linked to specific psychological traits. Moreover, non-linear analysis outperforms the psychological assessment with respect to standard analysis. Considering that the current clinical practice relies only on subjective scores from interviews and questionnaires, this study provides objective tools for the assessment of psychological dimensions. PMID:25859212

Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation.

PubMed

Meissner, Kamila A; Lunev, Sergey; Wang, Yuan-Ze; Linzke, Marleen; de Assis Batista, Fernando; Wrenger, Carsten; Groves, Matthew R

2017-01-01

The validation of drug targets in malaria and other human diseases remains a highly difficult and laborious process. In the vast majority of cases, highly specific small molecule tools to inhibit a proteins function in vivo are simply not available. Additionally, the use of genetic tools in the analysis of malarial pathways is challenging. These issues result in difficulties in specifically modulating a hypothetical drug target's function in vivo. The current "toolbox" of various methods and techniques to identify a protein's function in vivo remains very limited and there is a pressing need for expansion. New approaches are urgently required to support target validation in the drug discovery process. Oligomerisation is the natural assembly of multiple copies of a single protein into one object and this self-assembly is present in more than half of all protein structures. Thus, oligomerisation plays a central role in the generation of functional biomolecules. A key feature of oligomerisation is that the oligomeric interfaces between the individual parts of the final assembly are highly specific. However, these interfaces have not yet been systematically explored or exploited to dissect biochemical pathways in vivo. This mini review will describe the current state of the antimalarial toolset as well as the potentially druggable malarial pathways. A specific focus is drawn to the initial efforts to exploit oligomerisation surfaces in drug target validation. As alternative to the conventional methods, Protein Interference Assay (PIA) can be used for specific distortion of the target protein function and pathway assessment in vivo. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Development of SRS.php, a Simple Object Access Protocol-based library for data acquisition from integrated biological databases.

PubMed

Barbosa-Silva, A; Pafilis, E; Ortega, J M; Schneider, R

2007-12-11

Data integration has become an important task for biological database providers. The current model for data exchange among different sources simplifies the manner that distinct information is accessed by users. The evolution of data representation from HTML to XML enabled programs, instead of humans, to interact with biological databases. We present here SRS.php, a PHP library that can interact with the data integration Sequence Retrieval System (SRS). The library has been written using SOAP definitions, and permits the programmatic communication through webservices with the SRS. The interactions are possible by invoking the methods described in WSDL by exchanging XML messages. The current functions available in the library have been built to access specific data stored in any of the 90 different databases (such as UNIPROT, KEGG and GO) using the same query syntax format. The inclusion of the described functions in the source of scripts written in PHP enables them as webservice clients to the SRS server. The functions permit one to query the whole content of any SRS database, to list specific records in these databases, to get specific fields from the records, and to link any record among any pair of linked databases. The case study presented exemplifies the library usage to retrieve information regarding registries of a Plant Defense Mechanisms database. The Plant Defense Mechanisms database is currently being developed, and the proposal of SRS.php library usage is to enable the data acquisition for the further warehousing tasks related to its setup and maintenance.

Dynamic Agroecological Zones for the Inland Pacific Northwest, USA

NASA Astrophysics Data System (ADS)

Huggins, D. R.; Rupp, R.; Gessler, P.; Pan, W.; Brown, D. J.; Machado, S.; Walden, V. P.; Eigenbrode, S.; Abatzoglou, J. T.

2011-12-01

Agroecological zones (AEZ's) have traditionally been defined by integrating multiple layers of biophysical (e.g. climate, soil, terrain) and occasionally socioeconomic data to create unique zones with specific ranges of land use constraints and potentials. Our approach to defining AEZ's assumes that current agricultural land uses have emerged as a consequence of biophysical and socioeconomic drivers. Therefore, we explore the concept that AEZ's can be derived from classifying the geographic distribution of current agricultural systems (e.g. the wheat-fallow cropping system zone) based on spatially geo-referenced annual cropland use data that is currently available through the National Agricultural Statistical Service (NASS). By defining AEZ's in this way, we expect to: (1) provide baseline information that geographically delineates the boundaries of current AEZ's and subzones and therefore the capacity to evaluate shifts in AEZ boundaries over time; (2) assess the biophysical (e.g. climate, soils, terrain) and socioeconomic factors (e.g. commodity prices) that are most useful for predicting and correctly classifying current AEZ's, subzones or future shifts in AEZ boundaries; (3) identify and develop AEZ-relevant climate mitigation and adaptation strategies; and (4) integrate biophysical and socioeconomic data sources to pursue a transdisciplinary examination of climate-driven AEZ futures. Achieving these goals will aid in realizing major objectives for a USDA National Institute of Food and Agriculture, Agriculture and Food Research Initiative, Cooperative Agricultural Project entitled "Regional Approaches to Climate Change (REACCH) for Pacific Northwest Agriculture". REACCH is a research, education and extension project under the leadership of the University of Idaho with significant collaboration from Washington State University, Oregon State University and the USDA Agricultural Research Service that is working towards increasing the capacity of Inland Pacific Northwest cereal production systems to adapt to and mitigate climate change. The AEZ concept is central to project-wide integration that will enable researchers, stakeholders, students, the public, and policymakers to acquire a more holistic understanding of the interrelationships of agriculture, climate change and the development of mitigation and adaptation strategies. Therefore AEZ's are part of a prescription for land management, given climate change that will enable the incorporation of information from climate models, economic models, crop models, pest disease and weed vulnerabilities, and other data sources. Specific to this presentation, we address the AEZ-related objective of developing methodology for defining major AEZ's within the Inland Pacific Northwest REACCH study area based on annual NASS cropland data.

Pediatric stroke and transcranial direct current stimulation: methods for rational individualized dose optimization

PubMed Central

Gillick, Bernadette T.; Kirton, Adam; Carmel, Jason B.; Minhas, Preet; Bikson, Marom

2014-01-01

Background: Transcranial direct current stimulation (tDCS) has been investigated mainly in adults and doses may not be appropriate in pediatric applications. In perinatal stroke where potential applications are promising, rational adaptation of dosage for children remains under investigation. Objective: Construct child-specific tDCS dosing parameters through case study within a perinatal stroke tDCS safety and feasibility trial. Methods: 10-year-old subject with a diagnosis of presumed perinatal ischemic stroke and hemiparesis was identified. T1 magnetic resonance imaging (MRI) scans used to derive computerized model for current flow and electrode positions. Workflow using modeling results and consideration of dosage in previous clinical trials was incorporated. Prior ad hoc adult montages vs. de novo optimized montages provided distinct risk benefit analysis. Approximating adult dose required consideration of changes in both peak brain current flow and distribution which further tradeoff between maximizing efficacy and adding safety factors. Electrode size, position, current intensity, compliance voltage, and duration were controlled independently in this process. Results: Brain electric fields modeled and compared to values previously predicted models (Datta et al., 2011; Minhas et al., 2012). Approximating conservative brain current flow patterns and intensities used in previous adult trials for comparable indications, the optimal current intensity established was 0.7 mA for 10 min with a tDCS C3/C4 montage. Specifically 0.7 mA produced comparable peak brain current intensity of an average adult receiving 1.0 mA. Electrode size of 5 × 7 cm2 with 1.0 mA and low-voltage tDCS was employed to maximize tolerability. Safety and feasibility confirmed with subject tolerating the session well and no serious adverse events. Conclusion: Rational approaches to dose customization, with steps informed by computational modeling, may improve guidance for pediatric stroke tDCS trials. PMID:25285077

Mastering algebra retrains the visual system to perceive hierarchical structure in equations.

PubMed

Marghetis, Tyler; Landy, David; Goldstone, Robert L

2016-01-01

Formal mathematics is a paragon of abstractness. It thus seems natural to assume that the mathematical expert should rely more on symbolic or conceptual processes, and less on perception and action. We argue instead that mathematical proficiency relies on perceptual systems that have been retrained to implement mathematical skills. Specifically, we investigated whether the visual system-in particular, object-based attention-is retrained so that parsing algebraic expressions and evaluating algebraic validity are accomplished by visual processing. Object-based attention occurs when the visual system organizes the world into discrete objects, which then guide the deployment of attention. One classic signature of object-based attention is better perceptual discrimination within, rather than between, visual objects. The current study reports that object-based attention occurs not only for simple shapes but also for symbolic mathematical elements within algebraic expressions-but only among individuals who have mastered the hierarchical syntax of algebra. Moreover, among these individuals, increased object-based attention within algebraic expressions is associated with a better ability to evaluate algebraic validity. These results suggest that, in mastering the rules of algebra, people retrain their visual system to represent and evaluate abstract mathematical structure. We thus argue that algebraic expertise involves the regimentation and reuse of evolutionarily ancient perceptual processes. Our findings implicate the visual system as central to learning and reasoning in mathematics, leading us to favor educational approaches to mathematics and related STEM fields that encourage students to adapt, not abandon, their use of perception.

The Validity and Applicability of Using a Generic Exposure Assessment Model for Occupational Exposure to Nano-Objects and Their Aggregates and Agglomerates.

PubMed

Bekker, Cindy; Voogd, Eef; Fransman, Wouter; Vermeulen, Roel

2016-11-01

Control banding can be used as a first-tier assessment to control worker exposure to nano-objects and their aggregates and agglomerates (NOAA). In a second tier, more advanced modelling approaches are needed to produce quantitative exposure estimates. As currently no general quantitative nano-specific exposure models are available, this study evaluated the validity and applicability of using a generic exposure assessment model (the Advanced REACH Tool-ART) for occupational exposure to NOAA. The predictive capability of ART for occupational exposure to NOAA was tested by calculating the relative bias and correlations (Pearson) between the model estimates and measured concentrations using a dataset of 102 NOAA exposure measurements collected during experimental and workplace exposure studies. Moderate to (very) strong correlations between the ART estimates and measured concentrations were found. Estimates correlated better to measured concentration levels of dust (r = 0.76, P < 0.01) than liquid aerosols (r = 0.51, P = 0.19). However, ART overestimated the measured NOAA concentrations for both the experimental and field measurements (factor 2-127). Overestimation was highest at low concentrations and decreased with increasing concentration. Correlations seemed to be better when looking at the nanomaterials individually compared to combined scenarios, indicating that nanomaterial-specific characteristics are not well captured within the mechanistic model of the ART. Although ART in its current state is not capable to estimate occupational exposure to NOAA, the strong correlations for the individual nanomaterials indicate that the ART (and potentially other generic exposure models) have the potential to be extended or adapted for exposure to NOAA. In the future, studies investigating the potential to estimate exposure to NOAA should incorporate more explicitly nanomaterial-specific characteristics in their models. © The Author 2016. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Evaluation of gastro-oesophageal reflux disease in wheezy infants using 24-h oesophageal combined impedance and pH monitoring.

PubMed

Abdallah, Ahmed; El-Desoky, Tarek; Fathi, Khalid; Fawzi Elkashef, Wagdi; Zaki, Ahmed

2017-06-01

Gastro-oesophageal reflux disease (GERD) is incriminated as a cause of non-asthmatic infantile wheeze. To date, no diagnostic test is considered standard for GERD-related airway reflux diagnosis. Oesophageal combined multiple channel intraluminal impedance and pH (MII-pH) monitoring is proposed to be a sensitive tool for evaluation of all GERD including infantile wheeze. We aimed to determine the GERD prevalence amongst wheezy infants in the first year of life using combined MII-pH versus pH monitoring alone and evaluate the sensitivity and specificity of objective MII-pH monitoring parameters in GERD-associated infantile wheeze diagnosis compared to those of lipid-laden macrophage index (LLMI). Thirty-eight wheezy infants below 1year of age were evaluated for GERD using oesophageal combined MII-pH monitoring and LLMI. Totally, 60.5% of cases had abnormal MII-pH; only 7.9% of them had abnormal pH monitoring. LLMI was significantly higher in wheezy infants with abnormal MII-pH than infants with normal MII-pH monitoring (112±88 versus 70±48; P=0.036). The current definitions of abnormal MII-pH study, reflux index≥10% and distal reflux episodes≥100, had low sensitivity (23%) but high specificity (100% and 96%, respectively) in GERD-related aspiration diagnosis defined by LLMI≥100. Using ROC curves, bolus contact time≥2.4% and proximal reflux episodes≥46 had 61% and 54% sensitivity and 64% and 76% specificity, respectively, in GERD-related aspiration diagnosis. Combined MII-pH is superior to pH monitoring in reflux-associated infantile wheeze diagnosis. Objective data including proximal reflux episodes and bolus contact time should be combined with the current parameters used in reflux-associated infantile wheeze diagnosis. Copyright © 2017 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.

The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.

PubMed

Derewenda, Zygmunt S; Godzik, Adam

2017-01-01

Crystallization of macromolecules has long been perceived as a stochastic process, which cannot be predicted or controlled. This is consistent with another popular notion that the interactions of molecules within the crystal, i.e., crystal contacts, are essentially random and devoid of specific physicochemical features. In contrast, functionally relevant surfaces, such as oligomerization interfaces and specific protein-protein interaction sites, are under evolutionary pressures so their amino acid composition, structure, and topology are distinct. However, current theoretical and experimental studies are significantly changing our understanding of the nature of crystallization. The increasingly popular "sticky patch" model, derived from soft matter physics, describes crystallization as a process driven by interactions between select, specific surface patches, with properties thermodynamically favorable for cohesive interactions. Independent support for this model comes from various sources including structural studies and bioinformatics. Proteins that are recalcitrant to crystallization can be modified for enhanced crystallizability through chemical or mutational modification of their surface to effectively engineer "sticky patches" which would drive crystallization. Here, we discuss the current state of knowledge of the relationship between the microscopic properties of the target macromolecule and its crystallizability, focusing on the "sticky patch" model. We discuss state-of-the-art in silico methods that evaluate the propensity of a given target protein to form crystals based on these relationships, with the objective to design variants with modified molecular surface properties and enhanced crystallization propensity. We illustrate this discussion with specific cases where these approaches allowed to generate crystals suitable for structural analysis.

Event-scale relationships between surface velocity, temperature and chlorophyll in the coastal ocean, as seen by satellite

NASA Technical Reports Server (NTRS)

Strub, P. Ted

1991-01-01

The overall goal of this project was to increase our understanding of processes which determine the temporally varying distributions of surface chlorophyll pigment concentration and surface temperature in the California Current System (CCS) on the time-scale of 'events', i.e., several days to several weeks. We also proposed to investigate seasonal and regional differences in these events. Additionally, we proposed to evaluate methods of estimating surface velocities and horizontal transport of pigment and heat from sequences of AVHRR and CZCS images. The four specific objectives stated in the original proposal were to: (1) test surface current estimates made from sequences of both SST and color images using variations of the statistical method of Emery et al. (1986) and estimate the uncertainties in these satellite-derived surface currents; (2) characterize the spatial and temporal relationships of chlorophyll and temperature in rapidly evolving features for which adequate imagery exist and evaluate the contribution of these events to monthly and seasonal averages; (3) use the methods tested in (1) to determine the nature of the velocity fields in the CCS; and (4) compare the currents, temperature, and currents in different seasons and in different geographic regions.

Examining the Effects of Emotional and Cognitive Desensitization to Community Violence Exposure in Male Adolescents of Color

PubMed Central

Gaylord-Harden, Noni K.; So, Suzanna; Bai, Grace J.; Tolan, Patrick H.

2016-01-01

Objective The current study examined pathways in a model of desensitization, the Pathologic Adaptation Model, in adolescent males of color. Specifically, the current study examined depressive symptoms and deviant beliefs as mediators of the association between community violence exposure and subsequent violent behavior. Method The current study included 250 African American (67%) and Latino (33%) male adolescents (T1 mean age = 15.32) from the Chicago Youth Development Study. Results Consistent with the Pathologic Adaptation Model, results demonstrated that depressive symptoms mediated the association between the quadratic violence exposure term in middle adolescence and violent behaviors in late adolescence, but the direction of the mediation effect was dependent upon the levels of violence exposure in middle adolescence. However, deviant beliefs were not found to be a significant mediator. Conclusion Emotional desensitization effects may increase the likelihood of violence perpetration in adolescent males exposed to community violence, and the implications for future research and intervention efforts are discussed. PMID:27977283

Associative Symmetry versus Independent Associations in the Memory for Object-Location Associations

ERIC Educational Resources Information Center

Sommer, Tobias; Rose, Michael; Buchel, Christian

2007-01-01

The formation of associations between objects and locations is a vital aspect of episodic memory. More specifically, remembering the location where one experienced an object and, vice versa, the object one encountered at a specific location are both important elements for the memory of an event. Whether episodic associations are holistic…

Current developments in departmental PACS for ultrasound.

PubMed

Grenier, L E; Eng, P

1995-01-01

1. INTRODUCTION TO DEPARTMENTAL PACS. Full or partial Departmental PACS is generally taken to mean an image management system focused on serving the needs of a specific modality or modality application. It will provide a modality specific means of image acquisition, specialized redisplay of images, distribution, and local long term storage of images. A Departmental PACS can be considered in isolation or as a component in a distributed Radiology PACS which consists of one or more departmental work groups on a back bone, potentially with shared resources. 2. DEPARTMENTAL PACS Issues Implementation of a Departmental PACS requires an in-depth knowledge of departmental clinical practice and work flow in all affected areas in the department, including patient intake, image collection, data routing, retrieval of previous image data, reporting, and long term data management and storage. Optimization of modality specific image display systems requires significant involvement from representative physician users. System architectures and user interfaces must be flexible enough to support the span of variation in clinical practice encountered in the site. A departmental PACS should offer a variety of "open" communications interfaces, both local and wide area, recognizing that outreach efforts are often driven by specific imaging departments. Interfaces to other departmental PAC systems and other information systems must be considered in order to facilitate institutions developing "Best of Breed" PACS systems. As hospitals move toward the integrated electronic medical record, means need to exist for a client process launched from a physician desktop to acquire images and/or reports from a departmental system. At minimum, HIS/RIS interfaces need to be considered to minimize re-keying of data and reduce data entry errors. 3. DESIGN OBJECTIVES FOR ALI ULTRAPACS. The key objectives were to design a product which could function either as a free standing PACS or as a departmental subnet on a larger PACS backbone, one which could function in a local or mixed local and wide area environment and one which could provide a cost effective implementation based on currently available technologies. 4. IMPLEMENTATION STRATEGIES. In order to attain the product design objectives, ALI made the following critical implementation decisions: 1) to build the UltraPACS application as a suite of separable UNIX processes based on a message passing client server model; 2) to host the application and operating system on a Digital Equipment Corporation PC using an Intel microprocessor because of the competition and broad variety of suppliers in the PC arena; and 3) to use NEXTSTEP as the UNIX variant of choice because of NEXTSTEPUs strong object orientation, superb development tools, and the excellent integration between the Graphical User Interface level and the underlying operating system layers. 5. CONCLUSION. ALI is convinced that a departmental approach to PACS offers significant advantages over monolithic PACS in several key areas including: optimization for modality specific clinical practice and workflow, cost effectiveness, the potential for an institution to implement PACS in a stepwise fashion, starting with the department with the potential for the greatest savings, and the capability for an institution to build a "best of breed" solution for large scale PACS.

Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy

PubMed Central

Vickery, Brian P.; Scurlock, Amy M.; Kulis, Michael; Steele, Pamela H.; Kamilaris, Janet; Berglund, Jelena P.; Burk, Caitlin; Hiegel, Anne; Carlisle, Suzanna; Christie, Lynn; Perry, Tamara T.; Pesek, Robbie D.; Sheikh, Saira; Virkud, Yamini; Smith, P. Brian; Shamji, Mohamed H.; Durham, Stephen R.; Jones, Stacie M.; Burks, A. Wesley

2013-01-01

Background Although peanut oral immunotherapy (OIT) has been conclusively shown to cause desensitization, it is currently unknown whether clinical protection persists after stopping therapy. Objective Our primary objective was to determine whether peanut OIT can induce sustained unresponsiveness following withdrawal of OIT. Methods We conducted a pilot clinical trial of peanut OIT at two U.S. centers. Subjects aged 1–16 were recruited and treated for up to five years with peanut OIT. The protocol was modified over time to permit dose increases to a maximum of 4000 mg peanut protein/day. Blood was collected at multiple time points. Clinical endpoints were measured with 5000 mg double-blinded, placebo-controlled food challenges once specific criteria were met. Results Of the 39 subjects originally enrolled, 24 completed the protocol and had evaluable outcomes. 12/24 (50%) successfully passed a challenge one month after stopping OIT and achieved sustained unresponsiveness. Peanut was added to the diet. At baseline and the time of challenge, such subjects had smaller skin tests as well as lower IgE levels specific for peanut, Ara h 1, and Ara h 2, and lower ratios of peanut-specific:total IgE, compared to subjects not passing. There were no differences in peanut IgG4 levels or functional activity at end-of-study. Conclusions This is the first demonstration of sustained unresponsiveness after peanut OIT, occurring in half of subjects treated up to five years. OIT favorably modified the peanut-specific immune response in all subjects completing the protocol. Smaller skin tests and lower allergen-specific IgE levels were predictive of successful outcome. PMID:24361082

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guyer, H.B.; McChesney, C.A.

The overall primary Objective of HDAR is to create a repository of historical personnel security documents and provide the functionality needed for archival and retrieval use by other software modules and application users of the DISS/ET system. The software product to be produced from this specification is the Historical Document Archival and Retrieval Subsystem The product will provide the functionality to capture, retrieve and manage documents currently contained in the personnel security folders in DOE Operations Offices vaults at various locations across the United States. The long-term plan for DISS/ET includes the requirement to allow for capture and storage ofmore » arbitrary, currently undefined, clearance-related documents that fall outside the scope of the ``cradle-to-grave`` electronic processing provided by DISS/ET. However, this requirement is not within the scope of the requirements specified in this document.« less

Validation of alternative methods for toxicity testing.

PubMed Central

Bruner, L H; Carr, G J; Curren, R D; Chamberlain, M

1998-01-01

Before nonanimal toxicity tests may be officially accepted by regulatory agencies, it is generally agreed that the validity of the new methods must be demonstrated in an independent, scientifically sound validation program. Validation has been defined as the demonstration of the reliability and relevance of a test method for a particular purpose. This paper provides a brief review of the development of the theoretical aspects of the validation process and updates current thinking about objectively testing the performance of an alternative method in a validation study. Validation of alternative methods for eye irritation testing is a specific example illustrating important concepts. Although discussion focuses on the validation of alternative methods intended to replace current in vivo toxicity tests, the procedures can be used to assess the performance of alternative methods intended for other uses. Images Figure 1 PMID:9599695

MO-FG-207-03: Maximizing the Utility of Integrated PET/MRI in Clinical Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Behr, S.

2015-06-15

The use of integrated PET/MRI systems in clinical applications can best benefit from understanding their technological advances and limitations. The currently available clinical PET/MRI systems have their own characteristics. Thorough analyses of existing technical data and evaluation of necessary performance metrics for quality assurances could be conducted to optimize application-specific PET/MRI protocols. This Symposium will focus on technical advances and limitations of clinical PET/MRI systems, and how this exciting imaging modality can be utilized in applications that can benefit from both PET and MRI. Learning Objectives: To understand the technological advances of clinical PET/MRI systems To correctly identify clinical applicationsmore » that can benefit from PET/MRI To understand ongoing work to further improve the current PET/MRI technology Floris Jansen is a GE Healthcare employee.« less

MO-FG-207-00: Technological Advances in PET/MR Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

2015-06-15

The use of integrated PET/MRI systems in clinical applications can best benefit from understanding their technological advances and limitations. The currently available clinical PET/MRI systems have their own characteristics. Thorough analyses of existing technical data and evaluation of necessary performance metrics for quality assurances could be conducted to optimize application-specific PET/MRI protocols. This Symposium will focus on technical advances and limitations of clinical PET/MRI systems, and how this exciting imaging modality can be utilized in applications that can benefit from both PET and MRI. Learning Objectives: To understand the technological advances of clinical PET/MRI systems To correctly identify clinical applicationsmore » that can benefit from PET/MRI To understand ongoing work to further improve the current PET/MRI technology Floris Jansen is a GE Healthcare employee.« less

A review of accuracy assessment for object-based image analysis: From per-pixel to per-polygon approaches

NASA Astrophysics Data System (ADS)

Ye, Su; Pontius, Robert Gilmore; Rakshit, Rahul

2018-07-01

Object-based image analysis (OBIA) has gained widespread popularity for creating maps from remotely sensed data. Researchers routinely claim that OBIA procedures outperform pixel-based procedures; however, it is not immediately obvious how to evaluate the degree to which an OBIA map compares to reference information in a manner that accounts for the fact that the OBIA map consists of objects that vary in size and shape. Our study reviews 209 journal articles concerning OBIA published between 2003 and 2017. We focus on the three stages of accuracy assessment: (1) sampling design, (2) response design and (3) accuracy analysis. First, we report the literature's overall characteristics concerning OBIA accuracy assessment. Simple random sampling was the most used method among probability sampling strategies, slightly more than stratified sampling. Office interpreted remotely sensed data was the dominant reference source. The literature reported accuracies ranging from 42% to 96%, with an average of 85%. A third of the articles failed to give sufficient information concerning accuracy methodology such as sampling scheme and sample size. We found few studies that focused specifically on the accuracy of the segmentation. Second, we identify a recent increase of OBIA articles in using per-polygon approaches compared to per-pixel approaches for accuracy assessment. We clarify the impacts of the per-pixel versus the per-polygon approaches respectively on sampling, response design and accuracy analysis. Our review defines the technical and methodological needs in the current per-polygon approaches, such as polygon-based sampling, analysis of mixed polygons, matching of mapped with reference polygons and assessment of segmentation accuracy. Our review summarizes and discusses the current issues in object-based accuracy assessment to provide guidance for improved accuracy assessments for OBIA.

Effects of parallel planning on agreement production.

PubMed

Veenstra, Alma; Meyer, Antje S; Acheson, Daniel J

2015-11-01

An important issue in current psycholinguistics is how the time course of utterance planning affects the generation of grammatical structures. The current study investigated the influence of parallel activation of the components of complex noun phrases on the generation of subject-verb agreement. Specifically, the lexical interference account (Gillespie & Pearlmutter, 2011b; Solomon & Pearlmutter, 2004) predicts more agreement errors (i.e., attraction) for subject phrases in which the head and local noun mismatch in number (e.g., the apple next to the pears) when nouns are planned in parallel than when they are planned in sequence. We used a speeded picture description task that yielded sentences such as the apple next to the pears is red. The objects mentioned in the noun phrase were either semantically related or unrelated. To induce agreement errors, pictures sometimes mismatched in number. In order to manipulate the likelihood of parallel processing of the objects and to test the hypothesized relationship between parallel processing and the rate of agreement errors, the pictures were either placed close together or far apart. Analyses of the participants' eye movements and speech onset latencies indicated slower processing of the first object and stronger interference from the related (compared to the unrelated) second object in the close than in the far condition. Analyses of the agreement errors yielded an attraction effect, with more errors in mismatching than in matching conditions. However, the magnitude of the attraction effect did not differ across the close and far conditions. Thus, spatial proximity encouraged parallel processing of the pictures, which led to interference of the associated conceptual and/or lexical representation, but, contrary to the prediction, it did not lead to more attraction errors. Copyright © 2015 Elsevier B.V. All rights reserved.

Median prior constrained TV algorithm for sparse view low-dose CT reconstruction.

PubMed

Liu, Yi; Shangguan, Hong; Zhang, Quan; Zhu, Hongqing; Shu, Huazhong; Gui, Zhiguo

2015-05-01

It is known that lowering the X-ray tube current (mAs) or tube voltage (kVp) and simultaneously reducing the total number of X-ray views (sparse view) is an effective means to achieve low-dose in computed tomography (CT) scan. However, the associated image quality by the conventional filtered back-projection (FBP) usually degrades due to the excessive quantum noise. Although sparse-view CT reconstruction algorithm via total variation (TV), in the scanning protocol of reducing X-ray tube current, has been demonstrated to be able to result in significant radiation dose reduction while maintain image quality, noticeable patchy artifacts still exist in reconstructed images. In this study, to address the problem of patchy artifacts, we proposed a median prior constrained TV regularization to retain the image quality by introducing an auxiliary vector m in register with the object. Specifically, the approximate action of m is to draw, in each iteration, an object voxel toward its own local median, aiming to improve low-dose image quality with sparse-view projection measurements. Subsequently, an alternating optimization algorithm is adopted to optimize the associative objective function. We refer to the median prior constrained TV regularization as "TV_MP" for simplicity. Experimental results on digital phantoms and clinical phantom demonstrated that the proposed TV_MP with appropriate control parameters can not only ensure a higher signal to noise ratio (SNR) of the reconstructed image, but also its resolution compared with the original TV method. Copyright © 2015 Elsevier Ltd. All rights reserved.

Automatic thoracic body region localization

NASA Astrophysics Data System (ADS)

Bai, PeiRui; Udupa, Jayaram K.; Tong, YuBing; Xie, ShiPeng; Torigian, Drew A.

2017-03-01

Radiological imaging and image interpretation for clinical decision making are mostly specific to each body region such as head & neck, thorax, abdomen, pelvis, and extremities. For automating image analysis and consistency of results, standardizing definitions of body regions and the various anatomic objects, tissue regions, and zones in them becomes essential. Assuming that a standardized definition of body regions is available, a fundamental early step needed in automated image and object analytics is to automatically trim the given image stack into image volumes exactly satisfying the body region definition. This paper presents a solution to this problem based on the concept of virtual landmarks and evaluates it on whole-body positron emission tomography/computed tomography (PET/CT) scans. The method first selects a (set of) reference object(s), segments it (them) roughly, and identifies virtual landmarks for the object(s). The geometric relationship between these landmarks and the boundary locations of body regions in the craniocaudal direction is then learned through a neural network regressor, and the locations are predicted. Based on low-dose unenhanced CT images of 180 near whole-body PET/CT scans (which includes 34 whole-body PET/CT scans), the mean localization error for the boundaries of superior of thorax (TS) and inferior of thorax (TI), expressed as number of slices (slice spacing ≍ 4mm)), and using either the skeleton or the pleural spaces as reference objects, is found to be 3,2 (using skeleton) and 3, 5 (using pleural spaces) respectively, or in mm 13, 10 mm (using skeleton) and 10.5, 20 mm (using pleural spaces), respectively. Improvements of this performance via optimal selection of objects and virtual landmarks and other object analytics applications are currently being pursued. and the skeleton and pleural spaces used as a reference objects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ono, Shota, E-mail: shota-o@gifu-u.ac.jp; Department of Physics, Graduate School of Engineering, Yokohama National University, Yokohama 240-8501; Tanikawa, Kousei

Revealing a universal relation between geometrical structures and electronic properties of capped carbon nanotubes (CNTs) is one of the current objectives in nanocarbon community. Here, we investigate the local curvature of capped CNTs and define the cap region by a crossover behavior of the curvature energy versus the number of carbon atoms integrated from the tip to the tube region. Clear correlations among the energy gap of the cap localized states, the curvature energy, the number of carbon atoms in the cap region, and the number of specific carbon clusters are observed. The present analysis opens the way to understandmore » the cap states.« less

An overview of current Navy programs to develop thrust augmenting ejectors

NASA Technical Reports Server (NTRS)

Green, K. A.

1979-01-01

The primary objective of Navy sponsored research in thrust augmentation is the development of an improved augmenter for V/STOL application. In support of this goal, a data base is being established to provide an accurate prediction capability for use in ejector design. A general technology development of ejectors and associated effects presently is split into the more specific areas of lift and control, since thrust augmenting ejectors may be suitable for both. Research areas examined include advanced diffuser and end wall design; advanced primary nozzles; analytic studies; augmenting reaction controls; and nozzle design.

Cost Containment in Europe

PubMed Central

Culyer, A. J.

1989-01-01

Health care cost containment is not in itself a sensible policy objective, because any assessment of the appropriateness of health care expenditure in aggregate, as of that on specific programs, requires a balancing of costs and benefits at the margin. International data on expenditures can, however, provide indications of the likely impact on costs and expenditures of structural features of health care systems. Data from the Organization for Economic Cooperation and Development for both European countries and a wider set are reviewed, and some current policies in Europe that are directed at controlling health care costs are outlined. PMID:10313433

OAST space power technology program

NASA Technical Reports Server (NTRS)

Mullin, J. P.

1978-01-01

The current research and technology (R and T) base program is first described, then special attention is directed toward outlining a new system technology specifically oriented toward providing the utility power plant technology base for semi-permanent earth orbital facilities expected to be needed in the middle to late 1980's. The R and T program involves five areas of research: (1) photovoltaic energy conversion; (2) chemical energy conversion and storage; (3) thermal-to-electric conversion; (4) environment interactions; and (5) power systems management and distribution. The general objectives and planned direction of efforts in each of these areas is summarized.

The Ames Virtual Environment Workstation: Implementation issues and requirements

NASA Technical Reports Server (NTRS)

Fisher, Scott S.; Jacoby, R.; Bryson, S.; Stone, P.; Mcdowall, I.; Bolas, M.; Dasaro, D.; Wenzel, Elizabeth M.; Coler, C.; Kerr, D.

1991-01-01

This presentation describes recent developments in the implementation of a virtual environment workstation in the Aerospace Human Factors Research Division of NASA's Ames Research Center. Introductory discussions are presented on the primary research objectives and applications of the system and on the system's current hardware and software configuration. Principle attention is then focused on unique issues and problems encountered in the workstation's development with emphasis on its ability to meet original design specifications for computational graphics performance and for associated human factors requirements necessary to provide compelling sense of presence and efficient interaction in the virtual environment.

Representing object oriented specifications and designs with extended data flow notations

NASA Technical Reports Server (NTRS)

Buser, Jon Franklin; Ward, Paul T.

1988-01-01

The issue of using extended data flow notations to document object oriented designs and specifications is discussed. Extended data flow notations, for the purposes here, refer to notations that are based on the rules of Yourdon/DeMarco data flow analysis. The extensions include additional notation for representing real-time systems as well as some proposed extensions specific to object oriented development. Some advantages of data flow notations are stated. How data flow diagrams are used to represent software objects are investigated. Some problem areas with regard to using data flow notations for object oriented development are noted. Some initial solutions to these problems are proposed.

Attitude Accessibility as a Function of Emotionality.

PubMed

Rocklage, Matthew D; Fazio, Russell H

2018-04-01

Despite the centrality of both attitude accessibility and attitude basis to the last 30 years of theoretical and empirical work concerning attitudes, little work has systematically investigated their relation. The research that does exist provides conflicting results and is not at all conclusive given the methodology that has been used. The current research uses recent advances in statistical modeling and attitude measurement to provide the most systematic examination of the relation between attitude accessibility and basis to date. Specifically, we use mixed-effects modeling which accounts for variation across individuals and attitude objects in conjunction with the Evaluative Lexicon (EL)-a linguistic approach that allows for the simultaneous measurement of an attitude's valence, extremity, and emotionality. We demonstrate across four studies, over 10,000 attitudes, and nearly 50 attitude objects that attitudes based on emotion tend to be more accessible in memory, particularly if the attitude is positive.

Reconstruction of the Mesoscale Velocity Shear Seaward of Coastal Upwelling Regions from the Refraction of the Surface Wave Field

NASA Technical Reports Server (NTRS)

Flament, Pierre; Graber, Hans C.; Halpern, D.; Holt, B.

1996-01-01

The objective of this project is to study fronts that develop at the boundary between cold water recently upwelled to the surface through Ekman divergence, and warmer surrounding waters. This specific objective was suggested by studying the small scale structure of upwelling fronts (coastal, island, and equatorial) through shipboard surveys and infrared satellite images. Constraints on the shuttle equator crossing imposed by other land sites precluded a coverage of the area targeted in the initial SIR-C proposal, the California Current. The site was then relocated to the Equatorial Pacific upwelling tongue, that can be satisfactorily imaged for a wide range of longitudes of the equator crossing. Some limited data was nevertheless obtained over coastal upwelling off California in 1989, using the JPL AIRSAR in multifrequency mode, and over island upwelling off Hawaii in 1990, using the radar in along-track interferometric mode.

Compression-based integral curve data reuse framework for flow visualization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Fan; Bi, Chongke; Guo, Hanqi

Currently, by default, integral curves are repeatedly re-computed in different flow visualization applications, such as FTLE field computation, source-destination queries, etc., leading to unnecessary resource cost. We present a compression-based data reuse framework for integral curves, to greatly reduce their retrieval cost, especially in a resource-limited environment. In our design, a hierarchical and hybrid compression scheme is proposed to balance three objectives, including high compression ratio, controllable error, and low decompression cost. Specifically, we use and combine digitized curve sparse representation, floating-point data compression, and octree space partitioning to adaptively achieve the objectives. Results have shown that our data reusemore » framework could acquire tens of times acceleration in the resource-limited environment compared to on-the-fly particle tracing, and keep controllable information loss. Moreover, our method could provide fast integral curve retrieval for more complex data, such as unstructured mesh data.« less

Geosynchronous platform definition study. Volume 3: Geosynchronous mission characteristics

NASA Technical Reports Server (NTRS)

1973-01-01

The objectives of the study were to examine the nature of currently planned and new evolutionary geosynchronous programs, to analyze alternative ways of conducting missions, to establish concepts for new systems to support geosynchronous programs in an effective and economical manner, and to define the logistic support to carry out these programs. In order to meet these objectives, it was necessary to define and examine general geosynchronous mission characteristics and the potentially applicable electromagnetic spectrum characteristics. An organized compilation of these data is given with emphasis on the development and use of the data. Fundamental geosynchronous orbit time histories, mission profile characteristics, and delivery system characteristics are presented. In addition, electromagnetic spectrum utilization is discussed in terms of the usable frequency spectrum, the spectrum potentially available considering established frequency allocations, and the technology status as it affects the ability to operate within specific frequency bands.

Principles of Induction Accelerators

NASA Astrophysics Data System (ADS)

Briggs*, Richard J.

The basic concepts involved in induction accelerators are introduced in this chapter. The objective is to provide a foundation for the more detailed coverage of key technology elements and specific applications in the following chapters. A wide variety of induction accelerators are discussed in the following chapters, from the high current linear electron accelerator configurations that have been the main focus of the original developments, to circular configurations like the ion synchrotrons that are the subject of more recent research. The main focus in the present chapter is on the induction module containing the magnetic core that plays the role of a transformer in coupling the pulsed power from the modulator to the charged particle beam. This is the essential common element in all these induction accelerators, and an understanding of the basic processes involved in its operation is the main objective of this chapter. (See [1] for a useful and complementary presentation of the basic principles in induction linacs.)

Applying Augmented Reality in practical classes for engineering students

NASA Astrophysics Data System (ADS)

Bazarov, S. E.; Kholodilin, I. Yu; Nesterov, A. S.; Sokhina, A. V.

2017-10-01

In this article the Augmented Reality application for teaching engineering students of electrical and technological specialties is introduced. In order to increase the motivation for learning and the independence of students, new practical guidelines on Augmented Reality were developed in the application to practical classes. During the application development, the authors used software such as Unity 3D and Vuforia. The Augmented Reality content consists of 3D-models, images and animations, which are superimposed on real objects, helping students to study specific tasks. A user who has a smartphone, a tablet PC, or Augmented Reality glasses can visualize on-screen virtual objects added to a real environment. Having analyzed the current situation in higher education: the learner’s interest in studying, their satisfaction with the educational process, and the impact of the Augmented Reality application on students, a questionnaire was developed and offered to students; the study involved 24 learners.

The depiction of Alboran Sea Gyre during Donde Va? using remote sensing and conventional data

NASA Technical Reports Server (NTRS)

Laviolette, P. E.

1984-01-01

Experienced oceanographic investigators have come to realize that remote sensing techniques are most successful when applied as part of programs of integrated measurements aimed at solving specific oceanographic problems. A good example of such integration occurred during the multi-platform international experiment, Donde Va? in the Alboran Sea during the period June through October, 1982. The objective of Donde Va? was to derive the interrelationship of the Atlantic waters entering the Mediterranean Sea and the Alboran Sea Gyre. The experimental plan conceived solely with this objective in mind consisted of a variety of remote sensing and conventional platforms: three ships, three aircraft, five current moorings, two satellites and a specialized beach radar (CODAR). Integrated analyses of these multiple-data sets are still being conducted. However, the initial results show detailed structure of the incoming Atlantic jet and Alboran Sea Gyre that would not have been possible by conventional means.

A Review of Some Superconducting Technologies for AtLAST: Parametric Amplifiers, Kinetic Inductance Detectors, and On-Chip Spectrometers

NASA Astrophysics Data System (ADS)

Noroozian, Omid

2018-01-01

The current state of the art for some superconducting technologies will be reviewed in the context of a future single-dish submillimeter telescope called AtLAST. The technologies reviews include: 1) Kinetic Inductance Detectors (KIDs), which have now been demonstrated in large-format kilo-pixel arrays with photon background-limited sensitivity suitable for large field of view cameras for wide-field imaging. 2) Parametric amplifiers - specifically the Traveling-Wave Kinetic Inductance (TKIP) amplifier - which has enormous potential to increase sensitivity, bandwidth, and mapping speed of heterodyne receivers, and 3) On-chip spectrometers, which combined with sensitive direct detectors such as KIDs or TESs could be used as Multi-Object Spectrometers on the AtLAST focal plane, and could provide low-medium resolution spectroscopy of 100 objects at a time in each field of view.

Software systems for modeling articulated figures

NASA Technical Reports Server (NTRS)

Phillips, Cary B.

1989-01-01

Research in computer animation and simulation of human task performance requires sophisticated geometric modeling and user interface tools. The software for a research environment should present the programmer with a powerful but flexible substrate of facilities for displaying and manipulating geometric objects, yet insure that future tools have a consistent and friendly user interface. Jack is a system which provides a flexible and extensible programmer and user interface for displaying and manipulating complex geometric figures, particularly human figures in a 3D working environment. It is a basic software framework for high-performance Silicon Graphics IRIS workstations for modeling and manipulating geometric objects in a general but powerful way. It provides a consistent and user-friendly interface across various applications in computer animation and simulation of human task performance. Currently, Jack provides input and control for applications including lighting specification and image rendering, anthropometric modeling, figure positioning, inverse kinematics, dynamic simulation, and keyframe animation.

The engineered phytoremediation of ionic and methylmercury pollution 70054yr.2001.doc

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meagher, Richard B.

2001-06-01

Our long-term objective is to enable highly productive plant species to extract, resist, detoxify, and/or sequester toxic organic and heavy metal pollutants (Meagher, 2000) applying scientific strategies and technologies from a rapidly developing field called phytoremediation. The phytoremediation of toxic elemental and organic pollutants requires the use relatively different approaches (Meagher, 2000). Our current specific objectives are to use transgenic plants to control the chemical species, electrochemical state, and aboveground binding of mercury to (a) prevent methylmercury from entering the food-chain, (b) remove mercury from polluted sites, and (c) hyperaccumulate mercury in aboveground tissues for later harvest. Various parts ofmore » this strategy are being critically tested by examining different genes in model plants and field species and comparing the results to control plants as recently reviewed (Meagher et al., 2000; Rugh et al., 2000).« less

Mathematics education and learning disabilities in Spain.

PubMed

Casas, Ana Miranda; Castellar, Rosa García

2004-01-01

In the first part of this article, we describe the basic objectives of the math curriculum in Spain as well as the basic contents, teacher resources, and obstacles perceived in mathematics instruction. Second, we briefly describe the concept of learning disabilities (LD) as they are currently defined in Spain. As stated in the recent educational reform, a student with LD is any student with special educational needs. The emphasis is placed on the educational resources that these students need in order to achieve the curricular objectives that correspond to their age group or grade. Third, we comment specifically on the educational services model and the evaluation and instructional procedures for students with math learning disabilities. Finally, we describe some lines of research that have appeared in the last few years in Spain that have led to the development of new evaluation and intervention procedures for students with LD in computation and problem solving.

Object Toolkit Version 4.3 User’s Manual

DTIC Science & Technology

2016-12-31

unlimited. (OPS-17-12855 dtd 19 Jan 2017) 13. SUPPLEMENTARY NOTES 14. ABSTRACT Object Toolkit is a finite - element model builder specifically designed for...INTRODUCTION 1 What Is Object Toolkit? Object Toolkit is a finite - element model builder specifically designed for creating representations of spacecraft...Nascap-2k and EPIC, the user is not required to purchase or learn expensive finite element generators to create system models. Second, Object Toolkit

Dynamic information processing states revealed through neurocognitive models of object semantics

PubMed Central

Clarke, Alex

2015-01-01

Recognising objects relies on highly dynamic, interactive brain networks to process multiple aspects of object information. To fully understand how different forms of information about objects are represented and processed in the brain requires a neurocognitive account of visual object recognition that combines a detailed cognitive model of semantic knowledge with a neurobiological model of visual object processing. Here we ask how specific cognitive factors are instantiated in our mental processes and how they dynamically evolve over time. We suggest that coarse semantic information, based on generic shared semantic knowledge, is rapidly extracted from visual inputs and is sufficient to drive rapid category decisions. Subsequent recurrent neural activity between the anterior temporal lobe and posterior fusiform supports the formation of object-specific semantic representations – a conjunctive process primarily driven by the perirhinal cortex. These object-specific representations require the integration of shared and distinguishing object properties and support the unique recognition of objects. We conclude that a valuable way of understanding the cognitive activity of the brain is though testing the relationship between specific cognitive measures and dynamic neural activity. This kind of approach allows us to move towards uncovering the information processing states of the brain and how they evolve over time. PMID:25745632

[Gender-specific manifestations of daily physical activity and sedentary behaviour in elderly people of Surgut].

PubMed

Loginov, S I; Malkov, M N; Nikolayev, A Yu

2017-01-01

Objective of the study was to establish gender-specific characteristics of physical activity (PA) and sedentary behavior in elderly people living in Yugra North. 295 residents of Surgut (102 men aged 62,9±5,3 years, 35%; 193 women aged 61,9±3,8 years, 65%) were subject to a IPAQ-RU questionnaire. The study revealed the gender-specific differences in body length and mass, body mass and body fat indices. It was detected that more energy is spent on the housework and physical activity in the country (moderate-intensity physical activity for women and high-intensity one for men). The study data showed no statistically significant gender-specific differences in general physical activity. Sedentary behavior is more popular among men rather than women (2543 vs 2441 min/week). 47% of low-active men and 56% of women reported the sitting times of 6-9 hours per day, 42% - 9-12 hours per day. Actions need to be taken to increase physical activity which is low at the moment and decrease sedentary behavior which is currently on the high level.

Infants' Recognition of Objects Using Canonical Color

ERIC Educational Resources Information Center

Kimura, Atsushi; Wada, Yuji; Yang, Jiale; Otsuka, Yumiko; Dan, Ippeita; Masuda, Tomohiro; Kanazawa, So; Yamaguchi, Masami K.

2010-01-01

We explored infants' ability to recognize the canonical colors of daily objects, including two color-specific objects (human face and fruit) and a non-color-specific object (flower), by using a preferential looking technique. A total of 58 infants between 5 and 8 months of age were tested with a stimulus composed of two color pictures of an object…

Geometric Reasoning for Automated Planning

NASA Technical Reports Server (NTRS)

Clement, Bradley J.; Knight, Russell L.; Broderick, Daniel

2012-01-01

An important aspect of mission planning for NASA s operation of the International Space Station is the allocation and management of space for supplies and equipment. The Stowage, Configuration Analysis, and Operations Planning teams collaborate to perform the bulk of that planning. A Geometric Reasoning Engine is developed in a way that can be shared by the teams to optimize item placement in the context of crew planning. The ISS crew spends (at the time of this writing) a third or more of their time moving supplies and equipment around. Better logistical support and optimized packing could make a significant impact on operational efficiency of the ISS. Currently, computational geometry and motion planning do not focus specifically on the optimized orientation and placement of 3D objects based on multiple distance and containment preferences and constraints. The software performs reasoning about the manipulation of 3D solid models in order to maximize an objective function based on distance. It optimizes for 3D orientation and placement. Spatial placement optimization is a general problem and can be applied to object packing or asset relocation.

[The art cabinet and its current significance. Museum establishment of natural history in early modern times].

PubMed

Felfe, Robert

2008-01-01

For some time a hightened interest in so-called "curiosity cabinets" of the 16th to 18th century has surfaced in the historical sciences as well as in exhibitions with popular appeal, the arts and literature. Johann Laurentius Bausch was among those who assembled such a collection of natural history objects and artefacts. His curiosity cabinet was closely connected to his far more famous library and in his last will Bausch attempted to safeguard the coherence of the two. Against this background the article accentuates some of the aspects of his work from a perspective of a history of collections. One focus will thereby be on the practice of collecting as seemingly contradictory, being characterised on the one hand by the preservation of ancient knowledge as well as by scientific research based on specific objects. Another focus will be on curiosity cabinets as important platforms of exchange and means of social advancement. For the Academia Naturae Curiosorum exhibition objects and their publication were an important device of achieving recognition and protection from the Emperor's Court.

RASSP final technical report

NASA Astrophysics Data System (ADS)

1992-10-01

The overall objective of the DARPA/Tri-Service RASSP program is to demonstrate a capability to rapidly specify, produce, and yield domain-specific, affordable signal processors for use in Department of Defense systems such as automatic target acquisition, tracking, and recognition, electronic countermeasures, communications, and SIGINT. The objective of the study phase is to specify a recommended program plan for the government to use as a template for procurement of the RASSP design system and demonstration program. To accomplish that objective, the study phase program tasks are to specify a development methodology for signal processors (adaptable to various organizational design styles, and application areas), analyze the requirements in CAD/CAE tools to support the development methodology, identify the state and development plans of the industry relative to this area, and to recommend the additional developments not currently being addressed by the industry, which are recommended as RASSP developments. In addition, the RASSP study phase will define a linking approach for electronically linking design centers to manufacturing centers so a complete cycle for prototyping can be accomplished with significantly reduced cycle time.

Study of moving object detecting and tracking algorithm for video surveillance system

NASA Astrophysics Data System (ADS)

Wang, Tao; Zhang, Rongfu

2010-10-01

This paper describes a specific process of moving target detecting and tracking in the video surveillance.Obtain high-quality background is the key to achieving differential target detecting in the video surveillance.The paper is based on a block segmentation method to build clear background,and using the method of background difference to detecing moving target,after a series of treatment we can be extracted the more comprehensive object from original image,then using the smallest bounding rectangle to locate the object.In the video surveillance system, the delay of camera and other reasons lead to tracking lag,the model of Kalman filter based on template matching was proposed,using deduced and estimated capacity of Kalman,the center of smallest bounding rectangle for predictive value,predicted the position in the next moment may appare,followed by template matching in the region as the center of this position,by calculate the cross-correlation similarity of current image and reference image,can determine the best matching center.As narrowed the scope of searching,thereby reduced the searching time,so there be achieve fast-tracking.

The Risk Factors of Performance-Based Early Frailty in Midlife and Older Age.

PubMed

Peterson, Matthew J

2018-01-01

Background: Identifying impairments prior to onset of physical frailty may inform targeted interventions. An objective, clinically feasible early frailty measure, termed performance-based early frailty (PBEF) was developed, and antecedent and current risk factors were examined. Method: Data were from N = 104 participants of the Fels Longitudinal Study. PBEF was derived from age-specific cut points for time to complete five chair stands and walk four meters. "Pre-PBEF" and "PBEF" were defined as impairment in one or both measures, respectively. Candidate PBEF risk factors included body composition, health and quality of life, grip strength, and biomarker measures. Results: Pre-PBEF was identified in 26% and 30% of midlife and older adults, and PBEF was identified in 11% and 14% of midlife and older adults, respectively. When predicting midlife PBEF, only current physical activity was significant (odds ratio [OR] = 0.18). In older adults, PBEF status was predicted by previous heavier drinking (OR = 3.09), previous better grip strength (OR = 0.92), current poorer sleep habits (OR = 1.19), and current higher C-reactive protein concentrations (OR = 1.20). Conclusion: Differing age group patterns of predictors emerged, suggesting that PBEF in midlife is likely a state influenced by current health status, whereas older age PBEF is influenced by both current and antecedent factors.

A Simulation and Modeling Framework for Space Situational Awareness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olivier, S S

This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. The framework is based on a flexible, scalable architecture to enable efficient, physics-based simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. The details of the modeling and simulation framework are described, including hydrodynamic models of satellitemore » intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical brightness calculations, generic radar system models, generic optical system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The use of this integrated simulation and modeling framework on a specific scenario involving space debris is demonstrated.« less

Hybridization of decomposition and local search for multiobjective optimization.

PubMed

Ke, Liangjun; Zhang, Qingfu; Battiti, Roberto

2014-10-01

Combining ideas from evolutionary algorithms, decomposition approaches, and Pareto local search, this paper suggests a simple yet efficient memetic algorithm for combinatorial multiobjective optimization problems: memetic algorithm based on decomposition (MOMAD). It decomposes a combinatorial multiobjective problem into a number of single objective optimization problems using an aggregation method. MOMAD evolves three populations: 1) population P(L) for recording the current solution to each subproblem; 2) population P(P) for storing starting solutions for Pareto local search; and 3) an external population P(E) for maintaining all the nondominated solutions found so far during the search. A problem-specific single objective heuristic can be applied to these subproblems to initialize the three populations. At each generation, a Pareto local search method is first applied to search a neighborhood of each solution in P(P) to update P(L) and P(E). Then a single objective local search is applied to each perturbed solution in P(L) for improving P(L) and P(E), and reinitializing P(P). The procedure is repeated until a stopping condition is met. MOMAD provides a generic hybrid multiobjective algorithmic framework in which problem specific knowledge, well developed single objective local search and heuristics and Pareto local search methods can be hybridized. It is a population based iterative method and thus an anytime algorithm. Extensive experiments have been conducted in this paper to study MOMAD and compare it with some other state-of-the-art algorithms on the multiobjective traveling salesman problem and the multiobjective knapsack problem. The experimental results show that our proposed algorithm outperforms or performs similarly to the best so far heuristics on these two problems.

Participants’ perceptions and understanding of a malaria clinical trial in Bangladesh

PubMed Central

2014-01-01

Background Existing evidence suggests that there is often limited understanding among participants in clinical trials about the informed consent process, resulting in their providing consent without really understanding the purpose of the study, specific procedures, and their rights. The objective of the study was to determine the subjects’ understanding of research, perceptions of voluntariness and motivations for participation in a malaria clinical trial. Methods In this study semi-structured interviews of adult clinical trial participants with uncomplicated falciparum malaria were conducted in Ramu Upazila Health Complex, in Bangladesh. Results Of 16 participants, the vast majority (81%) were illiterate. All subjects had a ‘therapeutic misconception’ i.e. the trial was perceived to be conducted primarily for the benefit of individual patients when in fact the main objective was to provide information to inform public health policy. From the patients’ perspective, getting well from their illness was their major concern. Poor actual understanding of trial specific procedures was reported despite participants’ satisfaction with treatment and nursing care. Conclusion There is frequently a degree of overlap between research and provision of clinical care in malaria research studies. Patients may be motivated to participate to research without a good understanding of the principal objectives of the study despite a lengthy consent process. The findings suggest that use of a standard consent form following the current ICH-GCP guidelines does not result in achieving fully informed consent and the process should be revised, simplified and adapted to individual trial settings. PMID:24893933

Cyber Surveillance for Flood Disasters

PubMed Central

Lo, Shi-Wei; Wu, Jyh-Horng; Lin, Fang-Pang; Hsu, Ching-Han

2015-01-01

Regional heavy rainfall is usually caused by the influence of extreme weather conditions. Instant heavy rainfall often results in the flooding of rivers and the neighboring low-lying areas, which is responsible for a large number of casualties and considerable property loss. The existing precipitation forecast systems mostly focus on the analysis and forecast of large-scale areas but do not provide precise instant automatic monitoring and alert feedback for individual river areas and sections. Therefore, in this paper, we propose an easy method to automatically monitor the flood object of a specific area, based on the currently widely used remote cyber surveillance systems and image processing methods, in order to obtain instant flooding and waterlogging event feedback. The intrusion detection mode of these surveillance systems is used in this study, wherein a flood is considered a possible invasion object. Through the detection and verification of flood objects, automatic flood risk-level monitoring of specific individual river segments, as well as the automatic urban inundation detection, has become possible. The proposed method can better meet the practical needs of disaster prevention than the method of large-area forecasting. It also has several other advantages, such as flexibility in location selection, no requirement of a standard water-level ruler, and a relatively large field of view, when compared with the traditional water-level measurements using video screens. The results can offer prompt reference for appropriate disaster warning actions in small areas, making them more accurate and effective. PMID:25621609

A Virtual Reality Game to Assess Obsessive-Compulsive Disorder.

PubMed

van Bennekom, Martine J; Kasanmoentalib, M Soemiati; de Koning, Pelle P; Denys, Damiaan

2017-11-01

The retrospective and subjective nature of clinical interviews is an important shortcoming of current psychiatric diagnosis. Consequently, there is a clear need for objective and standardized tools. Virtual reality (VR) can be used to achieve controlled symptom provocation, which allows direct assessment for the clinician. We developed a video VR game to provoke and assess obsessive-compulsive disorder (OCD) symptoms in a standardized and controlled environment. The first objective was to evaluate if the VR game is capable of provoking symptoms in OCD patients as opposed to healthy controls. The second objective was to evaluate the tolerability of the VR game in OCD patients. The VR game was created using a first-person perspective and confronted patients with 15 OCD-specific items, while simultaneously measuring OCD symptoms, including the number of compulsions, anxiety, tension, uncertainty, and urge to control. In this pilot study, eight patients and eight healthy controls performed the VR game. OCD patients performed significantly more compulsions (U = 5, p = 0.003) during the VR game. The anxiety, tension, uncertainty, and urge to control in response to the specific items were also higher for OCD patients, although significance was not yet reached because of the small sample. There were no substantial adverse effects. The results of this pilot study indicate that the VR game is capable of provoking a variety of OCD symptoms in OCD patients, as opposed to healthy controls, and is a potential valuable tool to objectify and standardize an OCD diagnosis.

Participants' perceptions and understanding of a malaria clinical trial in Bangladesh.

PubMed

Das, Debashish; Cheah, Phaik Yeong; Akter, Fateha; Paul, Dulal; Islam, Akhterul; Sayeed, Abdullah A; Samad, Rasheda; Rahman, Ridwanur; Hossain, Amir; Dondorp, Arjen; Day, Nicholas P; White, Nicholas J; Hasan, Mahtabuddin; Ghose, Aniruddha; Ashley, Elizabeth A; Faiz, Abul

2014-06-04

Existing evidence suggests that there is often limited understanding among participants in clinical trials about the informed consent process, resulting in their providing consent without really understanding the purpose of the study, specific procedures, and their rights. The objective of the study was to determine the subjects' understanding of research, perceptions of voluntariness and motivations for participation in a malaria clinical trial. In this study semi-structured interviews of adult clinical trial participants with uncomplicated falciparum malaria were conducted in Ramu Upazila Health Complex, in Bangladesh. Of 16 participants, the vast majority (81%) were illiterate. All subjects had a 'therapeutic misconception' i.e. the trial was perceived to be conducted primarily for the benefit of individual patients when in fact the main objective was to provide information to inform public health policy. From the patients' perspective, getting well from their illness was their major concern. Poor actual understanding of trial specific procedures was reported despite participants' satisfaction with treatment and nursing care. There is frequently a degree of overlap between research and provision of clinical care in malaria research studies. Patients may be motivated to participate to research without a good understanding of the principal objectives of the study despite a lengthy consent process. The findings suggest that use of a standard consent form following the current ICH-GCP guidelines does not result in achieving fully informed consent and the process should be revised, simplified and adapted to individual trial settings.

Eddy Current System and Method for Crack Detection

NASA Technical Reports Server (NTRS)

Wincheski, Russell A. (Inventor); Simpson, John W. (Inventor)

2012-01-01

An eddy current system and method enables detection of sub-surface damage in a cylindrical object. The invention incorporates a dual frequency, orthogonally wound eddy current probe mounted on a stepper motor-controlled scanning system. The system is designed to inspect for outer surface damage from the interior of the cylindrical object.

Childhood Abuse and Current Health Problems among Older Adults: The Mediating Role of Self-Efficacy

PubMed Central

Sachs-Ericsson, Natalie; Medley, Amanda N.; Kendall – Tackett, Kathleen; Taylor, John

2011-01-01

Objectives Child abuse has negative consequences on health functioning and the self-concept. Prior studies have garnered support for these relationships in younger adults; yet few studies have looked at the effects of abuse on health in older adults and the psychosocial variables, specifically self-efficacy, that may influence the abuse-health relationship. Methods Data obtained from the Physical Health and Disability Study were used to explore the impact of child abuse on current medical problems among older adults who were screened on physical disability status (N=1396, Mean age = 67, SD = 10.2). The study was conducted in South Florida and employed a multiethnic sample that is representative of the general population in this area. Results Child abuse was associated with the number of current medical problems and disability. Child abuse was also related to lower self-efficacy, and self-efficacy explained the relationship between abuse and the number of health problems. Conclusions There are far reaching effects of child abuse on older adults' health and self-concept. Health care providers and gerontologists need to be aware that child abuse is a life-long risk factor for increased disability and specific health problems, especially among the elderly. Future research should examine treatments designed to increase self-efficacy, especially among those who experienced child abuse, and observe any positive effects on health functioning. PMID:21922052

Transverse field focused system

DOEpatents

Anderson, O.A.

1983-06-01

It is an object of the invention to provide a transport apparatus for a high current negative-ion beam which will bend the beam around corners through a baffled path in a differential pump or a neutron trap. It is another object of the invention to provide a transport apparatus for a high current negative-ion beam which will allow gas molecules in the beam to exit outwardly from the transport apparatus. A further object of the invention is to provide a multi-stage accelerator for a high current negative-ion beam which will enable acceleration of the beam to very high energy levels with a minimum loss of current carrying capacity. A still further object of the invention is to provide an apparatus for transport or accelertion of a sheet beam of negative ions which is shaped to confine the beam against divergence or expansion.

Fourier power, subjective distance, and object categories all provide plausible models of BOLD responses in scene-selective visual areas

PubMed Central

Lescroart, Mark D.; Stansbury, Dustin E.; Gallant, Jack L.

2015-01-01

Perception of natural visual scenes activates several functional areas in the human brain, including the Parahippocampal Place Area (PPA), Retrosplenial Complex (RSC), and the Occipital Place Area (OPA). It is currently unclear what specific scene-related features are represented in these areas. Previous studies have suggested that PPA, RSC, and/or OPA might represent at least three qualitatively different classes of features: (1) 2D features related to Fourier power; (2) 3D spatial features such as the distance to objects in a scene; or (3) abstract features such as the categories of objects in a scene. To determine which of these hypotheses best describes the visual representation in scene-selective areas, we applied voxel-wise modeling (VM) to BOLD fMRI responses elicited by a set of 1386 images of natural scenes. VM provides an efficient method for testing competing hypotheses by comparing predictions of brain activity based on encoding models that instantiate each hypothesis. Here we evaluated three different encoding models that instantiate each of the three hypotheses listed above. We used linear regression to fit each encoding model to the fMRI data recorded from each voxel, and we evaluated each fit model by estimating the amount of variance it predicted in a withheld portion of the data set. We found that voxel-wise models based on Fourier power or the subjective distance to objects in each scene predicted much of the variance predicted by a model based on object categories. Furthermore, the response variance explained by these three models is largely shared, and the individual models explain little unique variance in responses. Based on an evaluation of previous studies and the data we present here, we conclude that there is currently no good basis to favor any one of the three alternative hypotheses about visual representation in scene-selective areas. We offer suggestions for further studies that may help resolve this issue. PMID:26594164

Real-time design with peer tasks

NASA Technical Reports Server (NTRS)

Goforth, Andre; Howes, Norman R.; Wood, Jonathan D.; Barnes, Michael J.

1995-01-01

We introduce a real-time design methodology for large scale, distributed, parallel architecture, real-time systems (LDPARTS), as an alternative to those methods using rate or dead-line monotonic analysis. In our method the fundamental units of prioritization, work items, are domain specific objects with timing requirements (deadlines) found in user's specification. A work item consists of a collection of tasks of equal priority. Current scheduling theories are applied with artifact deadlines introduced by the designer whereas our method schedules work items to meet user's specification deadlines (sometimes called end-to-end deadlines). Our method supports these scheduling properties. Work item scheduling is based on domain specific importance instead of task level urgency and still meets as many user specification deadlines as can be met by scheduling tasks with respect to urgency. Second, the minimum (closest) on-line deadline that can be guaranteed for a work item of highest importance, scheduled at run time, is approximately the inverse of the throughput, measured in work items per second. Third, throughput is not degraded during overload and instead of resorting to task shedding during overload, the designer can specify which work items to shed. We prove these properties in a mathematical model.

A mixed-methods needs assessment of adult diabetes mellitus (type II) and hypertension care in Toledo, Belize.

PubMed

Dekker, Annette M; Amick, Ashley E; Scholcoff, Cecilia; Doobay-Persaud, Ashti

2017-02-28

Non-communicable diseases, including diabetes mellitus and hypertension, continue to disproportionately burden low- and middle-income countries. However, little research has been done to establish current practices and management of chronic disease in these settings. The objective of this study was to examine current clinical management and identify potential gaps in care of patients with diabetes mellitus and hypertension in the district of Toledo, Belize. The study used a mixed methodology to assess current practices and identify gaps in diabetes mellitus and hypertension care. One hundred and twenty charts of the general clinic population were reviewed to establish disease epidemiology. One hundred and seventy-eight diabetic and hypertensive charts were reviewed to assess current practices. Twenty providers completed questionnaires regarding diabetes mellitus and hypertension management. Twenty-five individuals with diabetes mellitus and/or hypertension answered a questionnaire and in-depth interview. The prevalence of diabetes mellitus and hypertension was 12%. Approximately 51% (n = 43) of patients with hypertension were at blood pressure goal and 26% (n = 21) diabetic patients were at glycemic goal based on current guidelines. Of the patients with uncontrolled diabetes, 49% (n = 29) were on two oral agents and only 10% (n = 6) were on insulin. Providers stated that barriers to appropriate management include concerns prescribing insulin and patient health literacy. Patients demonstrated a general understanding of the concept of chronic illness, however lacked specific knowledge regarding disease processes and self-management strategies. This study provides an initial overview of diabetes mellitus and hypertension management in a diverse patient population in rural Belize. Results indicate areas for future investigation and possible intervention, including barriers to insulin use and opportunities for lifestyle-specific disease education for patients.

A Survey of Hospice Volunteer Coordinators: Training Methods and Objectives of Current Hospice Volunteer Training Programs.

PubMed

Brock, Cara M; Herndon, Christopher M

2017-06-01

Currently more than 5800 hospice organizations operate in the United States. 1 Hospice organizations are required by the Centers for Medicare and Medicaid Services (CMS) to use volunteers for services provided to patients. 2 Although CMS regulates the amount of hours hospice volunteers should provide, there are currently no national requirements for objectives of training. 3 The purpose of this study was to gather information from a sample of hospices regarding volunteer coordinator background, current training for volunteers, importance of training objectives, and any comments regarding additional objectives. Representative state hospice organizations were contacted by e-mail requesting their participation and distribution of the survey throughout their member hospices. The survey asked demographical questions, along with ratings of training components based on perceived level of importance and time spent on each objective. A total of 90 surveys were received, and the response rate was undeterminable. Results showed the majority of hospices were nonprofit, had less than 100 currently trained volunteers, and maintained an average daily patient census of less than 50. Questions regarding training programs indicated that most use live lecture methods of approximately 19 hours or less in duration. Overall, responding hospice organizations agreed that all objectives surveyed were important in training volunteers. The small number of respondents to this survey makes generalization nationwide difficult, however it is a strong starting point for the development of further surveys on hospice volunteer training and achieving a standardized set of training objectives and delivery methods.

Climate change and health effects in Northwest Alaska

PubMed Central

Brubaker, Michael; Berner, James; Chavan, Raj; Warren, John

2011-01-01

This article provides examples of adverse health effects, including weather-related injury, food insecurity, mental health issues, and water infrastructure damage, and the responses to these effects that are currently being applied in two Northwest Alaska communities. Background In Northwest Alaska, warming is resulting in a broad range of unusual weather and environmental conditions, including delayed freeze-up, earlier breakup, storm surge, coastal erosion, and thawing permafrost. These are just some of the climate impacts that are driving concerns about weather-related injury, the spread of disease, mental health issues, infrastructure damage, and food and water security. Local leaders are challenged to identify appropriate adaptation strategies to address climate impacts and related health effects. Implementation process The tribal health system is combining local observations, traditional knowledge, and western science to perform community-specific climate change health impact assessments. Local leaders are applying this information to develop adaptation responses. Objective The Alaska Native Tribal Health Consortium will describe relationships between climate impacts and health effects and provide examples of community-scaled adaptation actions currently being applied in Northwest Alaska. Findings Climate change is increasing vulnerability to injury, disease, mental stress, food insecurity, and water insecurity. Northwest communities are applying adaptation approaches that are both specific and appropriate. Conclusion The health impact assessment process is effective in raising awareness, encouraging discussion, engaging partners, and implementing adaptation planning. With community-specific information, local leaders are applying health protective adaptation measures. PMID:22022304