Juvenile nasopharyngeal angiofibroma staging: An overview.

PubMed

Alshaikh, Nada Ali; Eleftheriadou, Anna

2015-06-01

Staging of tumors is very important in treatment and surgical decision making, as well as in predicting disease recurrence and prognosis. This review focuses on the different available classifications of juvenile nasopharyngeal angiofibroma (JNA) and their impact on the evaluation, management, and prognosis of JNA. The literature was reviewed, and publications on JNA staging were examined. Our MEDLINE search of the entire English-language literature found no review article on the current available staging systems for JNA. In this article, we review the common JNA classification systems that have been published, and we discuss some of their advantages and disadvantages. The most commonly used staging systems for JNA are the Radkowski and the Andrews-Fisch staging systems. However, some newer staging systems that are based on advances in technology and surgical approaches-the Onerci, INCan, and UPMC systems-have shown promising utility, and they will probably gain popularity in the future.

Adjuvant treatment of stage IB NSCLC: the problem of stage subset heterogeneity.

PubMed

Calhoun, Royce; Jablons, David; Lau, Derick; Gandara, David R

2008-04-30

While 5-year survival rates in patients with stage IB non-small-cell lung cancer (NSCLC) are historically modest (40% to 67%), adjuvant chemotherapy trials including this subgroup have shown little evidence of chemotherapeutic benefit. This article reviews the available data regarding adjuvant chemotherapy following surgically resected stage IB NSCLC, framed within the context of present and future proposed definitions of this diagnosis. The discussion addresses limitations of the current staging system and how this contributes to the mixed results seen with adjuvant treatment. In addition, the authors consider current treatment options for stage IB NSCLC and review planned clinical trials for stage I disease designed to exploit new pharmacogenomic findings.

Modeling of switching regulator power stages with and without zero-inductor-current dwell time

NASA Technical Reports Server (NTRS)

Lee, F. C. Y.; Yu, Y.

1979-01-01

State-space techniques are employed to derive accurate models for the three basic switching converter power stages: buck, boost, and buck/boost operating with and without zero-inductor-current dwell time. A generalized procedure is developed which treats the continuous-inductor-current mode without dwell time as a special case of the discontinuous-current mode when the dwell time vanishes. Abrupt changes of system behavior, including a reduction of the system order when the dwell time appears, are shown both analytically and experimentally. Merits resulting from the present modeling technique in comparison with existing modeling techniques are illustrated.

Using a Two-Stage System Evaluation Approach to Explore the New Adoption of an Information System in the Mobile Era

ERIC Educational Resources Information Center

Chen, Ruey-Shin; Liu, I-Fan

2017-01-01

Currently, e-learning systems are being widely used in all stages of education. However, it is difficult for school administrators to accurately assess the actual usage performance of a new system, especially when an organization wishes to update the system for users from different backgrounds using new devices such as smartphones. To allow school…

Staging systems of hepatocellular carcinoma: A review of literature

PubMed Central

Maida, Marcello; Orlando, Emanuele; Cammà, Calogero; Cabibbo, Giuseppe

2014-01-01

Hepatocellular carcinoma (HCC) is a major health problem with a high incidence and mortality all over the world. Natural history of HCC is severe and extremely variable, and prognostic factors influencing outcomes are incompletely defined. Over time, many staging and scoring systems have been proposed for the classification and prognosis of patients with HCC. Currently, the non-ideal predictive performance of existing prognostic systems is secondary to their inherent limitations, as well as to a non-universal reproducibility and transportability of the results in different populations. New serological and histological markers are still under evaluation with promising results, but they require further evaluation and external validation. The aim of this review is to highlight the main tools for assessing the prognosis of HCC and the main concerns, pitfalls and warnings regarding its staging systems currently in use. PMID:24764652

Technical and Economical Feasibility of SSTO and TSTO Launch Vehicles

NASA Astrophysics Data System (ADS)

Lerch, Jens

This paper discusses whether it is more cost effective to launch to low earth orbit in one or two stages, assuming current or near future technologies. First the paper provides an overview of the current state of the launch market and the hurdles to introducing new launch vehicles capable of significantly lowering the cost of access to space and discusses possible routes to solve those problems. It is assumed that reducing the complexity of launchers by reducing the number of stages and engines, and introducing reusability will result in lower launch costs. A number of operational and historic launch vehicle stages capable of near single stage to orbit (SSTO) performance are presented and the necessary steps to modify them into an expendable SSTO launcher and an optimized two stage to orbit (TSTO) launcher are shown, through parametric analysis. Then a ballistic reentry and recovery system is added to show that reusable SSTO and TSTO vehicles are also within the current state of the art. The development and recurring costs of the SSTO and the TSTO systems are estimated and compared. This analysis shows whether it is more economical to develop and operate expendable or reusable SSTO or TSTO systems under different assumption for launch rate and initial investment.

W.a.w (we are watching) smart app: accommodating social perception towards public officers’ performance

NASA Astrophysics Data System (ADS)

Widhoyoko, S. A.; Sasmoko; Nasir, L. A.; Manalu, S. R.; Indrianti, Y.

2018-03-01

This research is a continuation of previous research that is corruption early prevention is expanded by using expert system to analyze data and produce information to build decision. The research method used is neuroresearch method through three stages of research, namely exploratory stage, explanatory stage and confirmatory stages. The exploratory research finds W.aW’s Principles and W.a.W’s Units of Assessment as the basis for the preparation of the application. Stages of explanatory research in the form of W.a.W’s design of IT and confirmatory research stages are the design of expert system W.a.W. Expert System uses this formulation to generate dynamic standard value for each category and current social perception.

Proposal of a novel system for the staging of thymic epithelial tumors.

PubMed

Bedini, Amedeo Vittorio; Andreani, Stefano Michele; Tavecchio, Luca; Fabbri, Alessandra; Giardini, Roberto; Camerini, Tiziana; Bufalino, Rosaria; Morabito, Alberto; Rosai, Juan

2005-12-01

We designed and assessed a new TNM staging system (herein called the INT [Istituto Nazionale Tumori] system) for thymic epithelial tumors in order to overcome the perceived drawbacks of Masaoka's system, which represents the current standard. In all, 123 cases were evaluated. The histologic types according to the World Health Organization (WHO) classification were as follows: subtype A: 5 cases; AB: 40; B1: 16; B2: 29; B3: 16; and C: 17 cases. There were 45 Masaoka's stage I, 33 stage II, 26 stage III, and 19 stage IV cases. A total of 11 INT definitions were grouped into three stages: locally restricted disease (75 cases), which included Masaoka's stage I and selected stage II cases (no pleural invasion); locally advanced disease (37 cases), which included Masaoka's stage III cases plus those staged II owing to pleural invasion and those staged IV owing to intrathoracic nodal or limited pleuropericardial involvement; and systemic disease (11 cases), which included the remaining Masaoka's stage IV cases. Completeness of resection, WHO types, and both staging systems were significant prognostic factors (p < 0.0001) on univariate analysis. The 95-month progression-free survival rates according to Masaoka's system were stage I: 100%; II: 93.6%; III: 46.3%; and IV: 23.2%. The INT system corresponding figures were as follows: locally restricted disease: 98.6%; locally advanced disease: 46.9%; and systemic disease: 11.7%. The INT system was the prognostic factor with the greatest impact (p = 0.0218) on multivariate analysis (Masaoka's system: p = 0.2012; completeness of resection: p = 0.6855; histology: p = 0.9386). The INT system allows finer disease descriptions than Masaoka's system, resulting in a stage grouping with higher prognostic distinctiveness.

Recent advances in multidisciplinary management of hepatocellular carcinoma

PubMed Central

Gomaa, Asmaa I; Waked, Imam

2015-01-01

The incidence of hepatocellular carcinoma (HCC) is increasing, and it is currently the second leading cause of cancer-related death worldwide. Potentially curative treatment options for HCC include resection, transplantation, and percutaneous ablation, whereas palliative treatments include trans-arterial chemoembolization (TACE), radioembolization, and systemic treatments. Due to the diversity of available treatment options and patients’ presentations, a multidisciplinary team should decide clinical management of HCC, according to tumor characteristics and stage of liver disease. Potentially curative treatments are suitable for very-early- and early-stage HCC. However, the vast majority of HCC patients are diagnosed in later stages, where the tumor characteristics or progress of liver disease prevent curative interventions. For patients with intermediate-stage HCC, TACE and radioembolization improve survival and are being evaluated in addition to potentially curative therapies or with systemic targeted therapy. There is currently no effective systemic chemotherapy, immunologic, or hormonal therapy for HCC, and sorafenib is the only approved molecular-targeted treatment for advanced HCC. Other targeted agents are under investigation; trials comparing new agents in combination with sorafenib are ongoing. Combinations of systemic targeted therapies with local treatments are being evaluated for further improvements in HCC patient outcomes. This article provides an updated and comprehensive overview of the current standards and trends in the treatment of HCC. PMID:25866604

Aerosciences, Aero-Propulsion and Flight Mechanics Technology Development for NASA's Next Generation Launch Technology Program

NASA Technical Reports Server (NTRS)

Cockrell, Charles E., Jr.

2003-01-01

The Next Generation Launch Technology (NGLT) program, Vehicle Systems Research and Technology (VSR&T) project is pursuing technology advancements in aerothermodynamics, aeropropulsion and flight mechanics to enable development of future reusable launch vehicle (RLV) systems. The current design trade space includes rocket-propelled, hypersonic airbreathing and hybrid systems in two-stage and single-stage configurations. Aerothermodynamics technologies include experimental and computational databases to evaluate stage separation of two-stage vehicles as well as computational and trajectory simulation tools for this problem. Additionally, advancements in high-fidelity computational tools and measurement techniques are being pursued along with the study of flow physics phenomena, such as boundary-layer transition. Aero-propulsion technology development includes scramjet flowpath development and integration, with a current emphasis on hypervelocity (Mach 10 and above) operation, as well as the study of aero-propulsive interactions and the impact on overall vehicle performance. Flight mechanics technology development is focused on advanced guidance, navigation and control (GN&C) algorithms and adaptive flight control systems for both rocket-propelled and airbreathing vehicles.

Clinical diagnosis and staging of cholangiocarcinoma

PubMed Central

Blechacz, Boris; Komuta, Mina; Roskams, Tania; Gores, Gregory J.

2012-01-01

Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Currently, cholangiocarcinoma is classified into the following types according to its anatomic location along the biliary tree: intrahepatic, perihilar or distal extrahepatic cholangiocarcinoma. These cholangiocarcinoma types differ in their biological behavior and management. The appropriate stratification of patients with regard to the anatomic location and stage of cholangiocarcinoma is a key determinate in their management. Staging systems can guide this stratification and provide prognostic information. In addition, staging systems are essential in order to compare and contrast the outcomes of different therapeutic approaches. A number of staging systems exist for cholangiocarcinoma—several early ones have been updated, and new ones are being developed. We discuss the emerging diagnostic criteria as well as the different staging systems for cholangiocarcinoma, and provide a critical appraisal regarding these advances in biliary tract malignancies. PMID:21808282

On-coil multiple channel transmit system based on class-D amplification and pre-amplification with current amplitude feedback.

PubMed

Gudino, Natalia; Heilman, Jeremiah A; Riffe, Matthew J; Heid, Oliver; Vester, Markus; Griswold, Mark A

2013-07-01

A complete high-efficiency transmit amplifier unit designed to be implemented in on-coil transmit arrays is presented. High power capability, low power dissipation, scalability, and cost minimization were some of the requirements imposed to the design. The system is composed of a current mode class-D amplifier output stage and a voltage mode class-D preamplification stage. The amplitude information of the radio frequency pulse was added through a customized step-down DC-DC converter with current amplitude feedback that connects to the current mode class-D stage. Benchtop measurements and imaging experiments were carried out to analyze system performance. Direct control of B1 was possible and its load sensitivity was reduced to less than 10% variation from unloaded to full loaded condition. When using the amplifiers in an array configuration, isolation above 20 dB was achieved between neighboring coils by the amplifier decoupling method. High output current operation of the transmitter was proved on the benchtop through output power measurements and in a 1.5T scanner through flip angle quantification. Finally, single and multiple channel excitations with the new hardware were demonstrated by receiving signal with the body coil of the scanner. Copyright © 2012 Wiley Periodicals, Inc.

On the economics of staging for reusable launch vehicles

NASA Astrophysics Data System (ADS)

Griffin, Michael D.; Claybaugh, William R.

1996-03-01

There has been much recent discussion concerning possible replacement systems for the current U.S. fleet of launch vehicles, including both the shuttle and expendable vehicles. Attention has been focused upon the feasibility and potential benefits of reusable single-stage-to-orbit (SSTO) launch systems for future access to low Earth orbit (LEO). In this paper we assume the technical feasibility of such vehicles, as well as the benefits to be derived from system reusability. We then consider the benefits of launch vehicle staging from the perspective of economic advantage rather than performance necessity. Conditions are derived under which two-stage-to-orbit (TSTO) launch systems, utilizing SSTO-class vehicle technology, offer a relative economic advantage for access to LEO.

"Whose Responsibility Is It?": The Third Sector and the Educational System in Israel

ERIC Educational Resources Information Center

Eden, Devorah

2012-01-01

This study aims to explore the relationships between the third sector and the educational system in Israel in light of their current increasing involvement with one another. This was investigated along four stages of the policy process ranging from initial agenda-setting to final implementation. The stage of policy these relationships reached was…

Evaluating Managerial Styles for System Development Life Cycle Stages to Ensure Software Project Success

ERIC Educational Resources Information Center

Kocherla, Showry

2012-01-01

Information technology (IT) projects are considered successful if they are completed on time, within budget, and within scope. Even though, the required tools and methodologies are in place, IT projects continue to fail at a higher rate. Current literature lacks explanation for success within the stages of system development life-cycle (SDLC) such…

A discussion of serum albumin level in advanced-stage hepatocellular carcinoma: a medical oncologist's perspective.

PubMed

Tanriverdi, Ozgur

2014-11-01

Hepatocellular carcinoma is the most common primary malignant tumor of the liver, and it is particularly prevalent in East and Southeast Asia. With surgical and/or local interventional treatment methods, survival rates for early-stage hepatocellular cancers have increased. However, it is not yet clear which staging systems are more applicable in hepatocellular carcinoma. Serum albumin level is already being used as a criterion in most staging systems. Albumin is an important serum protein in human bodily functions, but only 5 % of the daily amount needed is synthesized by the liver. The serum albumin level is affected by multifactorial situations, including capillary permeability, drugs, liver insufficiency, inflammation and/or infections, dehydration or overhydration, protein loosing disorders, and decreased nutrition intake in anorexia-malnutrition syndrome and cancer cachexia. Because of this complex situation, serum albumin level may affect many staging systems for hepatocellular carcinoma by leading to false-negative results. In this paper, the statuses of current staging systems are reviewed, and possible negative events regarding the serum albumin levels found in these staging systems are discussed.

Cascade redox flow battery systems

DOEpatents

Horne, Craig R.; Kinoshita, Kim; Hickey, Darren B.; Sha, Jay E.; Bose, Deepak

2014-07-22

A reduction/oxidation ("redox") flow battery system includes a series of electrochemical cells arranged in a cascade, whereby liquid electrolyte reacts in a first electrochemical cell (or group of cells) before being directed into a second cell (or group of cells) where it reacts before being directed to subsequent cells. The cascade includes 2 to n stages, each stage having one or more electrochemical cells. During a charge reaction, electrolyte entering a first stage will have a lower state-of-charge than electrolyte entering the nth stage. In some embodiments, cell components and/or characteristics may be configured based on a state-of-charge of electrolytes expected at each cascade stage. Such engineered cascades provide redox flow battery systems with higher energy efficiency over a broader range of current density than prior art arrangements.

Modifying the criteria of the American Joint Commission on Cancer staging system in melanoma.

PubMed

Ross, M

1998-03-01

The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and modifications are suggested based on a review of the recent literature: 1) for stage I and II patients, Clark's level of invasion is only predictive in patients with melanomas less than 1 mm, the best statistical fit for tumor thickness cutoffs are less than 1 mm, 1 to 2 mm, 2 to 4 mm, and greater than 4 mm, and ulceration should be included as part of the staging system; 2) in stage III patients, the presently used criteria of 3 cm in size needs to abandoned and replaced by the number of lymph nodes involved and the number of lymph node basins involved; and 3) local recurrence presenting as local metastases and satellite disease represent a biologic continuum of regional lymphatic dissemination and should both be classified in the stage III prognostic groups. These modifications, if accepted, should provide the ability to better stratify patients for future adjuvant therapy trials.

The science of computing - The evolution of parallel processing

NASA Technical Reports Server (NTRS)

Denning, P. J.

1985-01-01

The present paper is concerned with the approaches to be employed to overcome the set of limitations in software technology which impedes currently an effective use of parallel hardware technology. The process required to solve the arising problems is found to involve four different stages. At the present time, Stage One is nearly finished, while Stage Two is under way. Tentative explorations are beginning on Stage Three, and Stage Four is more distant. In Stage One, parallelism is introduced into the hardware of a single computer, which consists of one or more processors, a main storage system, a secondary storage system, and various peripheral devices. In Stage Two, parallel execution of cooperating programs on different machines becomes explicit, while in Stage Three, new languages will make parallelism implicit. In Stage Four, there will be very high level user interfaces capable of interacting with scientists at the same level of abstraction as scientists do with each other.

Two Stages Cooperative Learning by Ability Indicators

ERIC Educational Resources Information Center

Wu, YuLung

2013-01-01

The teaching system in Taiwan is currently based on large classes where teachers cannot control student situations totally. In E-Learning System, a teacher who reviews a student's learning situation must examine the students' learning records according to different items, and further organize and define the students' current learning situations,…

Ares First Stage "Systemology" - Combining Advanced Systems Engineering and Planning Tools to Assure Mission Success

NASA Technical Reports Server (NTRS)

Seiler, James; Brasfield, Fred; Cannon, Scott

2008-01-01

Ares is an integral part of NASA s Constellation architecture that will provide crew and cargo access to the International Space Station as well as low earth orbit support for lunar missions. Ares replaces the Space Shuttle in the post 2010 time frame. Ares I is an in-line, two-stage rocket topped by the Orion Crew Exploration Vehicle, its service module, and a launch abort system. The Ares I first stage is a single, five-segment reusable solid rocket booster derived from the Space Shuttle Program's reusable solid rocket motor. The Ares second or upper stage is propelled by a J-2X main engine fueled with liquid oxygen and liquid hydrogen. This paper describes the advanced systems engineering and planning tools being utilized for the design, test, and qualification of the Ares I first stage element. Included are descriptions of the current first stage design, the milestone schedule requirements, and the marriage of systems engineering, detailed planning efforts, and roadmapping employed to achieve these goals.

Modeling Two-Stage Bunch Compression With Wakefields: Macroscopic Properties And Microbunching Instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bosch, R.A.; Kleman, K.J.; /Wisconsin U., SRC

2011-09-08

In a two-stage compression and acceleration system, where each stage compresses a chirped bunch in a magnetic chicane, wakefields affect high-current bunches. The longitudinal wakes affect the macroscopic energy and current profiles of the compressed bunch and cause microbunching at short wavelengths. For macroscopic wavelengths, impedance formulas and tracking simulations show that the wakefields can be dominated by the resistive impedance of coherent edge radiation. For this case, we calculate the minimum initial bunch length that can be compressed without producing an upright tail in phase space and associated current spike. Formulas are also obtained for the jitter in themore » bunch arrival time downstream of the compressors that results from the bunch-to-bunch variation of current, energy, and chirp. Microbunching may occur at short wavelengths where the longitudinal space-charge wakes dominate or at longer wavelengths dominated by edge radiation. We model this range of wavelengths with frequency-dependent impedance before and after each stage of compression. The growth of current and energy modulations is described by analytic gain formulas that agree with simulations.« less

Orbit Transfer Systems with Emphasis on Shuttle Applications, 1986-1991

NASA Technical Reports Server (NTRS)

1977-01-01

A systems study is presented for a transportation system which will follow the interim upper stage and spinning solid upper stage. Included are concepts, concept comparisons, trends, parametric data, etc. associated with the future system. Relevant technical and programmatic information is developed. This information is intended to focus future activity to identify attractive options and to summarize the major issues associated with the future development of the system. To establish a common basis for identifying current transportation concepts, an orbit transfer vehicle (OTV) is defined as a propulsive (velocity producing) rocket or stage. When used with a crew transfer module, a manned sortie module or other payloads, the combination becomes an orbit transfer system (OTS). Standardization of OTV's and OTS's is required.

Multi-stage separations based on dielectrophoresis

DOEpatents

Mariella, Jr., Raymond P.

2004-07-13

A system utilizing multi-stage traps based on dielectrophoresis. Traps with electrodes arranged transverse to the flow and traps with electrodes arranged parallel to the flow with combinations of direct current and alternating voltage are used to trap, concentrate, separate, and/or purify target particles.

Fact Sheet: Final Rule Determining Widespread use of Onboard Refueling Vapor Recovery and Waiver of Stage Two Requirements

EPA Pesticide Factsheets

Read the May 2012 factsheet on the rule that waived the requirement that current and former ozone nonattainment areas classifiedSerious and above, implement Stage II vapor recovery systems on gasoline pumps.

On-coil multiple channel transmit system based on class-D amplification and pre-amplification with current amplitude feedback

PubMed Central

Gudino, N.; Heilman, J.A; Riffe, M. J.; Heid, O.; Vester, M.; Griswold, M.A.

2016-01-01

A complete high-efficiency transmit amplifier unit designed to be implemented in on-coil transmit arrays is presented. High power capability, low power dissipation, scalability and cost minimization were some of the requirements imposed to the design. The system is composed of a current mode class-D (CMCD) amplifier output stage and a voltage mode class-D (VMCD) preamplification stage. The amplitude information of the radio frequency pulse was added through a customized step-down DC-DC converter with current amplitude feedback that connects to the CMCD stage. Benchtop measurements and imaging experiments were carried out to analyze system performance. Direct control of B1 was possible and its load sensitivity was reduced to less than 10% variation from unloaded to full loaded condition. When using the amplifiers in an array configuration, isolation above 20 dB was achieved between neighboring coils by the amplifier decoupling method. High output current operation of the transmitter was proved on the benchtop through output power measurements and in a 1.5 T scanner through flip angle quantification. Finally, single and multiple channel excitations with the new hardware were demonstrated by receiving signal with the body coil of the scanner. PMID:22890962

On the Significance of Fuzzification of the N and M in Cancer Staging

PubMed Central

Yones, Sara A; Moussa, Ahmed S; Hassan, Hesham; Alieldin, Nelly H

2014-01-01

The tumor, node, metastasis (TNM) staging system has been regarded as one of the most widely used staging systems for solid cancer. The “T” is assigned a value according to the primary tumor size, whereas the “N” and “M” are dependent on the number of regional lymph nodes and the presence of distant metastasis, respectively. The current TNM model classifies stages into five crisp classes. This is unrealistic since the drastic modification in treatment that is based on a change in one class may be based on a slight shift around the class boundary. Moreover, the system considers any tumor that has distant metastasis as stage 4, disregarding the metastatic lesion concentration and size. We had handled the problem of T staging in previous studies using fuzzy logic. In this study, we focus on the fuzzification of N and M staging for more accurate and realistic modeling which may, in turn, lead to better treatment and medical decisions. PMID:25089089

Impact of Capital and Current Costs Changes of the Incineration Process of the Medical Waste on System Management Cost

NASA Astrophysics Data System (ADS)

Jolanta Walery, Maria

2017-12-01

The article describes optimization studies aimed at analysing the impact of capital and current costs changes of medical waste incineration on the cost of the system management and its structure. The study was conducted on the example of an analysis of the system of medical waste management in the Podlaskie Province, in north-eastern Poland. The scope of operational research carried out under the optimization study was divided into two stages of optimization calculations with assumed technical and economic parameters of the system. In the first stage, the lowest cost of functioning of the analysed system was generated, whereas in the second one the influence of the input parameter of the system, i.e. capital and current costs of medical waste incineration on economic efficiency index (E) and the spatial structure of the system was determined. Optimization studies were conducted for the following cases: with a 25% increase in capital and current costs of incineration process, followed by 50%, 75% and 100% increase. As a result of the calculations, the highest cost of system operation was achieved at the level of 3143.70 PLN/t with the assumption of 100% increase in capital and current costs of incineration process. There was an increase in the economic efficiency index (E) by about 97% in relation to run 1.

NASA Ares I Launch Vehicle Roll and Reaction Control Systems Design Status

NASA Technical Reports Server (NTRS)

Butt, Adam; Popp, Chris G.; Pitts, Hank M.; Sharp, David J.

2009-01-01

This paper provides an update of design status following the preliminary design review of NASA s Ares I first stage roll and upper stage reaction control systems. The Ares I launch vehicle has been chosen to return humans to the moon, mars, and beyond. It consists of a first stage five segment solid rocket booster and an upper stage liquid bi-propellant J-2X engine. Similar to many launch vehicles, the Ares I has reaction control systems used to provide the vehicle with three degrees of freedom stabilization during the mission. During launch, the first stage roll control system will provide the Ares I with the ability to counteract induced roll torque. After first stage booster separation, the upper stage reaction control system will provide the upper stage element with three degrees of freedom control as needed. Trade studies and design assessments conducted on the roll and reaction control systems include: propellant selection, thruster arrangement, pressurization system configuration, and system component trades. Since successful completion of the preliminary design review, work has progressed towards the critical design review with accomplishments made in the following areas: pressurant / propellant tank, thruster assembly, and other component configurations, as well as thruster module design, and waterhammer mitigation approach. Also, results from early development testing are discussed along with plans for upcoming system testing. This paper concludes by summarizing the process of down selecting to the current baseline configuration for the Ares I roll and reaction control systems.

Prognostication in eye cancer: the latest tumor, node, metastasis classification and beyond

PubMed Central

Kivelä, T; Kujala, E

2013-01-01

The tumour, node, metastasis (TNM) classification is a universal cancer staging system, which has been used for five decades. The current seventh edition became effective in 2010 and covers six ophthalmic sites: eyelids, conjunctiva, uvea, retina, orbit, and lacrimal gland; and five cancer types: carcinoma, sarcoma, melanoma, retinoblastoma, and lymphoma. The TNM categories are based on the anatomic extent of the primary tumour (T), regional lymph node metastases (N), and systemic metastases (M). The T categories of ophthalmic cancers are based on the size of the primary tumour and any invasion of periocular structures. The anatomic category is used to determine the TNM stage that correlates with survival. Such staging is currently implemented only for carcinoma of the eyelid and melanoma of the uvea. The classification of ciliary body and choroidal melanoma is the only one based on clinical evidence so far: a database of 7369 patients analysed by the European Ophthalmic Oncology Group. It spans a prognosis from 96% 5-year survival for stage I to 97% 5-year mortality for stage IV. The most accurate criterion for prognostication in uveal melanoma is, however, analysis of chromosomal alterations and gene expression. When such data are available, the TNM stage may be used for further stratification. Prognosis in retinoblastoma is frequently assigned by using an international classification, which predicts conservation of the eye and vision, and an international staging separate from the TNM system, which predicts survival. The TNM cancer staging manual is a useful tool for all ophthalmologists managing eye cancer. PMID:23258307

Flood-inundation maps for the Tippecanoe River at Winamac, Indiana

USGS Publications Warehouse

Menke, Chad D.; Bunch, Aubrey R.

2015-09-25

For this study, flood profiles were computed for the Tippecanoe River reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at the Tippecanoe River streamgage, in combination with the current (2014) Federal Emergency Management Agency flood-insurance study for Pulaski County. The calibrated hydraulic model was then used to determine nine water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The 1-percent annual exceedance probability (AEP) flood stage (flood with recurrence intervals within 100 years) has not been determined yet for this streamgage location. The rating has not been developed for the 1-percent AEP because the streamgage dates to only 2001. The simulated water-surface profiles were then used with a geographic information system (GIS) digital elevation model (DEM, derived from Light Detection and Ranging [lidar]) in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage 03331753, Tippecanoe River at Winamac, Ind., and forecast stream stages from the NWS AHPS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

75 FR 49029 - Medicare Program; End-Stage Renal Disease Prospective Payment System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

...This final rule implements a case-mix adjusted bundled prospective payment system (PPS) for Medicare outpatient end-stage renal disease (ESRD) dialysis facilities beginning January 1, 2011 (ESRD PPS), in compliance with the statutory requirement of the Medicare Improvements for Patients and Providers Act (MIPPA), enacted July 15, 2008. This ESRD PPS also replaces the current basic case-mix adjusted composite payment system and the methodologies for the reimbursement of separately billable outpatient ESRD services.

Proposal for a new T-stage classification system for distal cholangiocarcinoma: a 10-institution study from the U.S. Extrahepatic Biliary Malignancy Consortium.

PubMed

Postlewait, Lauren M; Ethun, Cecilia G; Le, Nina; Pawlik, Timothy M; Buettner, Stefan; Poultsides, George; Tran, Thuy; Idrees, Kamran; Isom, Chelsea A; Fields, Ryan C; Krasnick, Bradley; Weber, Sharon M; Salem, Ahmed; Martin, Robert C G; Scoggins, Charles; Shen, Perry; Mogal, Harveshp D; Schmidt, Carl; Beal, Eliza; Hatzaras, Ioannis; Vitiello, Gerardo; Cardona, Kenneth; Maithel, Shishir K

2016-10-01

Seventh AJCC distal cholangiocarcinoma T-stage classification inadequately separates patients by survival. This retrospective study aimed to define a novel T-stage system to better stratify patients after resection. Curative-intent pancreaticoduodenectomies for distal cholangiocarcinoma (1/2000-5/2015) at 10 US institutions were included. Relationships between tumor characteristics and overall survival (OS) were assessed and incorporated into a novel T-stage classification. 176 patients (median follow-up: 24mo) were included. Current AJCC T-stage was not associated with OS (T1: 23mo, T2: 20mo, T3: 25mo, T4: 12mo; p = 0.355). Tumor size ≥3 cm and presence of lymphovascular invasion (LVI) were associated with decreased OS on univariate and multivariable analyses. Patients were stratified into 3 groups [T1: size <3 cm and (-)LVI (n = 69; 39.2%); T2: size ≥3 cm and (-)LVI or size <3 cm and (+)LVI (n = 82; 46.6%); and T3: size ≥3 cm and (+)LVI (n = 25; 14.2%)]. Each progressive proposed T-stage was associated with decreased median OS (T1: 35mo; T2: 20mo; T3: 8mo; p = 0.002). Current AJCC distal cholangiocarcinoma T-stage does not adequately stratify patients by survival. This proposed T-stage classification, based on tumor size and LVI, better differentiates patient outcomes after resection and could be considered for incorporation into the next AJCC distal cholangiocarcinoma staging system. Copyright © 2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

Revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System: Revised Pressure Injury Staging System.

PubMed

Edsberg, Laura E; Black, Joyce M; Goldberg, Margaret; McNichol, Laurie; Moore, Lynn; Sieggreen, Mary

Our understanding of pressure injury etiology and development has grown in recent years through research, clinical expertise, and global interdisciplinary expert collaboration. Therefore, the National Pressure Ulcer Advisory Panel (NPUAP) has revised the definition and stages of pressure injury. The revision was undertaken to incorporate the current understanding of the etiology of pressure injuries, as well as to clarify the anatomical features present or absent in each stage of injury. An NPUAP-appointed Task Force reviewed the literature and created drafts of definitions, which were then reviewed by stakeholders and the public, including clinicians, educators, and researchers around the world. Using a consensus-building methodology, these revised definitions were the focus of a multidisciplinary consensus conference held in April 2016. As a result of stakeholder and public input, along with the consensus conference, important changes were made and incorporated into the new staging definitions. The revised staging system uses the term injury instead of ulcer and denotes stages using Arabic numerals rather than Roman numerals. The revised definition of a pressure injury now describes the injuries as usually occurring over a bony prominence or under a medical or other device. The revised definition of a Stage 2 pressure injury seeks to clarify the difference between moisture-associated skin damage and injury caused by pressure and/or shear. The term suspected has been removed from the Deep Tissue Pressure Injury diagnostic label. Each definition now describes the extent of tissue loss present and the anatomical features that may or may not be present in the stage of injury. These important revisions reflect the methodical and collaborative approach used to examine the available evidence and incorporate current interdisciplinary clinical expertise into better defining the important phenomenon of pressure injury etiology and development.

Para-aortic nodal metastases in cervical cancer: a blind spot in the International Federation of Gynecology and Obstetrics staging system: current diagnosis and management.

PubMed

Hwang, Lindsay; Bailey, April; Lea, Jayanthi; Albuquerque, Kevin

2015-01-01

In cervical cancer, para-aortic nodal (PALN) metastases at presentation is a strong indicator of poor prognosis. Despite this, International Federation of Gynecology and Obstetrics staging system does not require evaluation of lymph node involvement and does not incorporate clinically detected PALN into the staging system. In the USA, despite screening, a significant number of women still present at an advanced stage often with nodal metastases. While the presence of PALN metastases often indicates occult systemic disease, it is possible with modern therapies to provide long-term control of disease in a percentage of patients. We review the epidemiology, diagnosis and treatment of PALN metastases in cervical cancer outlining advances in modern imaging and combined modality therapies (surgery, chemotherapy and radiation therapy).

Revised Tubiana’s Staging System for Assessment of Disease Severity in Dupuytren’s Disease—Preliminary Clinical Findings

PubMed Central

Hindocha, Sandip; Stanley, John K.; Watson, James Stewart

2007-01-01

There are few objective staging systems to assess severity of Dupuytren’s disease (DD). Previous methods to assess severity of DD were based primarily on the degree of contracture of an affected digit measured using a goniometer. Nonetheless, this method of assessment alone may be incomplete, and other factors should be considered. White (n = 92) patients diagnosed with DD from northwest of England were assessed for DD. Objective criteria for evaluating severity incorporated quantified variables. The revised severity stage was correlated to a known staging system of DD (Tubiana’s staging system) which measures total flexion deformity for a single affected digit. Total revised severity staging scores ranged between 4 and 53 (mean = 18.7) and revealed significant positive correlation to Tubiana’s original staging system (r2 = 0.8, p < 0.001). There was significant difference between severity staging scores in those with a positive family history compared to those without (p < 0.01). In current practice, often, the degree of contracture in an affected digit is used solely as a measure of disease severity. Additional objective clinical information may provide useful prognostic indices for disease progression as well as postoperative outcome. PMID:18780081

Systematic analyses of vibration noise of a vibration isolation system for high-resolution scanning tunneling microscopes.

PubMed

Iwaya, Katsuya; Shimizu, Ryota; Hashizume, Tomihiro; Hitosugi, Taro

2011-08-01

We designed and constructed an effective vibration isolation system for stable scanning tunneling microscopy measurements using a separate foundation and two vibration isolation stages (i.e., a combination of passive and active vibration isolation dampers). Systematic analyses of vibration data along the horizontal and vertical directions are present, including the vibration transfer functions of each stage and the overall vibration isolation system. To demonstrate the performance of the system, tunneling current noise measurements are conducted with and without the vibration isolation. Combining passive and active vibration isolation dampers successfully removes most of the vibration noise in the tunneling current up to 100 Hz. These comprehensive vibration noise data, along with details of the entire system, can be used to establish a clear guideline for building an effective vibration isolation system for various scanning probe microscopes and electron microscopes.

Analysis of the staging maneuver and booster glideback guidance for a two-stage, winged, fully reusable launch vehicle. M.S. Thesis - George Washington Univ.

NASA Technical Reports Server (NTRS)

Naftel, J. Christopher; Powell, Richard W.

1993-01-01

One of the promising launch concepts that could replace the current space shuttle launch system is a two-stage, winged, vertical-takeoff, fully reusable launch vehicle. During the boost phase of ascent, the booster provides propellant for the orbiter engines through a cross-feed system. When the vehicle reaches a Mach number of 3, the booster propellants are depleted and the booster is staged and glides unpowered to a horizontal landing at a launch site runway. Two major design issues for this class of vehicle are the staging maneuver and the booster glideback. For the staging maneuver analysis, a technique was developed that provides for a successful separation of the booster from the orbiter over a wide range of staging angles of attack. A longitudinal flight control system was developed for control of the booster during the staging maneuver. For the booster glide back analysis, a guidance algorithm was developed that successfully guides the booster from the completion of the staging maneuver to a launch site runway while encountering many off-nominal atmospheric, aerodynamic, and staging conditions.

The Lethality Test System

NASA Astrophysics Data System (ADS)

Parsons, W. M.; Sims, J. R.; Parker, J. V.

1986-11-01

The Lethality Test System (LTS) under construction at Los Alamos is an electromagnetic launcher facility designed to perform impact experiments at velocities up to 15 km/sec. The launcher is a 25 mm round bore, plasma armature railgun 22 m in length. Preinjection is accomplished with a two-stage light gas gun capable of 7 km/sec. The railgun power supply utilizes traction motors, vacuum interrupters, and pulse transformers. An assembly of 28 traction motors, equipped with flywheels, stores approximately 80 MJ at 92 percent of full speed and energizes the primary windings of three pulse transformers at a current of 50 kA. At peak current an array of vacuum interrupters disconnects the transformer primary windings and forces the current to flow in the secondary windings. The secondary windings are connected to the railgun, and by staging the vacuum interrupter openings, a 1-1.3 MA ramped current waveform will be delivered to the railgun.

Design of a wideband CMOS impedance spectroscopy ASIC analog front-end for multichannel biosensor interfaces.

PubMed

Valente, Virgilio; Dai Jiang; Demosthenous, Andreas

2015-08-01

This paper presents the preliminary design and simulation of a flexible and programmable analog front-end (AFE) circuit with current and voltage readout capabilities for electric impedance spectroscopy (EIS). The AFE is part of a fully integrated multifrequency EIS platform. The current readout comprises of a transimpedance stage and an automatic gain control (AGC) unit designed to accommodate impedance changes larger than 3 order of magnitude. The AGC is based on a dynamic peak detector that tracks changes in the input current over time and regulates the gain of a programmable gain amplifier in order to optimise the signal-to-noise ratio. The system works up to 1 MHz. The voltage readout consists of a 2 stages of fully differential current-feedback instrumentation amplifier which provide 100 dB of CMRR and a programmable gain up to 20 V/V per stage with a bandwidth in excess of 10MHz.

Surgical management and outcome of locoregional neuroblastoma: comparison of the Childrens Cancer Group and the international staging systems.

PubMed

Haase, G M; Atkinson, J B; Stram, D O; Lukens, J N; Matthay, K K

1995-02-01

Although precise anatomic staging is prognostically important in neuroblastoma, most widely employed staging systems remain incompatible. The International Neuroblastoma Staging System (INSS) was formulated to incorporate the basic elements of several systems to and define the significance of tumor resectability, anatomic "midline," and lymph node involvement. The authors sought to determine the applicability and value of the INSS compared with the classic Evans system. Between 1980 and 1992, 424 children with the diagnosis of local or regional neuroblastoma were entered in Childrens Cancer Group (CCG) clinical trials. The patients were assigned to Evans stage I, II, or III, by clinical and surgicopathologic assessment, and were treated uniformly by Group-wide therapy protocols. INSS stage 1, 2A, 2B, or 3, was applied, by retrospective analysis, to the children in the earlier studies, and by prospective evaluation of recent patients in the current studies. Survival and relapse-free survival (RFS) rates were determined and compared, based on age at diagnosis, extent of resection, and staging reassignment. All 87 Evans stage I patients were classified as INSS stage 1 and had a 92% 3-year RFS rate. Of the 144 Evans stage II patients, 65 also qualified as INSS stage 1 patients, with an 82% RFS rate. The other 79 stage II children remained in INSS stage 2A or 2B and had a 70% RFS rate (P = .10). Of the 193 Evans stage III patients, 24 were reassigned to INSS stage 1 (85% RFS rate) and 33 to stage 2A or 2B (65% survival rate; 61% RFS rate).(ABSTRACT TRUNCATED AT 250 WORDS)

Ngas Multi-Stage Coaxial High Efficiency Cooler (hec)

NASA Astrophysics Data System (ADS)

Nguyen, T.; Toma, G.; Jaco, C.; Raab, J.

2010-04-01

This paper presents the performance data of the single and two-stage High Efficiency Cooler (HEC) tested with coaxial cold heads. The single stage coaxial cold head has been optimized to operate at temperatures of 40 K and above. The two-stage parallel cold head configuration has been optimized to operate at 30 K and above and provides a long-life, low mass and efficient two-stage version of the Northrop Grumman Aerospace Systems (NGAS) flight qualified single stage HEC cooler. The HEC pulse tube cryocoolers are the latest generation of flight coolers with heritage to the 12 Northrop Grumman Aerospace Systems (NGAS) coolers currently on orbit with 2 operating for more than 11.5 years. This paper presents the performance data of the one and two-stage versions of this cooler under a wide range of heat rejection temperature, cold head temperature and input power.

[Coupling coordinated development of ecological-economic system in Loess Plateau].

PubMed

Zhang, Qing-Feng; Wu, Fa-Qi; Wang, Li; Wang, Jian

2011-06-01

Based on system theory, a coupling coordinated development model of ecological-economic system in Loess Plateau was established, and the evaluation criteria and basic types of the coordinated development of the ecological-economic system were proposed. The county-level coupling coordinated development of the ecological-economic system was also discussed, based on the local characteristics. The interactions between the ecological and economic systems in Loess Plateau could be divided into four stages, i.e., seriously disordered development stage, mild-disordered development stage, low-level coordinated development stage, and high level well-coordinated development stage. At each stage, there existed a cyclic process of profit and loss-antagonist-running-dominant-synchronous development. The coupling development degree of the ecological-economic system in Loess Plateau was overall at a lower level, being about 62.7% of the counties at serious disorder, 30.1% of the counties at mild disorder, and 7.1% of the counties at low but coordinated level. The coupling development degree based on the model established in this study could better reflect the current social-economic and ecological environment situations, especially the status of coordination. To fully understand the coupling of ecological-economic system and to adopt appropriate development mode would be of significance to promote the county-level coordinated development in Loess Plateau.

Imaging and detection of early stage dental caries with an all-optical photoacoustic microscope

NASA Astrophysics Data System (ADS)

Hughes, D. A.; Sampathkumar, A.; Longbottom, C.; Kirk, K. J.

2015-01-01

Tooth decay, at its earliest stages, manifests itself as small, white, subsurface lesions in the enamel. Current methods for detection in the dental clinic are visual and tactile investigations, and bite-wing X-ray radiographs. These techniques suffer from poor sensitivity and specificity at the earliest (and reversible) stages of the disease due to the small size (<100μm) of the lesion. A fine-resolution (600 nm) ultra-broadband (200 MHz) all-optical photoacoustic microscopy system was is used to image the early signs of tooth decay. Ex-vivo tooth samples exhibiting white spot lesions were scanned and were found to generate a larger (one order of magnitude) photoacoustic (PA) signal in the lesion regions compared to healthy enamel. The high contrast in the PA images potentially allows lesions to be imaged and measured at a much earlier stage than current clinical techniques allow. PA images were cross referenced with histology photographs to validate our experimental results. Our PA system provides a noncontact method for early detection of white-spot lesions with a high detection bandwidth that offers advantages over previously demonstrated ultrasound methods. The technique provides the sensing depth of an ultrasound system, but with the spatial resolution of an optical system.

Engine/vehicle integration for vertical takeoff and landing single stage to orbit vehicles

NASA Astrophysics Data System (ADS)

Weegar, R. K.

1992-08-01

SSTO vehicles design which is currently being developed under the Single Stage Rocket Technology program of the Strategic Defense Initiative Organization is discussed. Particular attention is given to engine optimization and integration of ascent, orbital, and landing propulsion requirements into a single system.

TOPS: Toward Other Planetary Systems. A report by the solar system exploration division

NASA Technical Reports Server (NTRS)

1995-01-01

This report describes a general plan and the pertinent technological requirements for TOPS (Toward Other Planetary Systems), a staged program to ascertain the prevalence and character of other planetary systems and to construct a definitive picture of the formation of stars and their planets. The first stages focus on discovering and studying a significant number of fully formed planetary systems, as well as expanding current studies of protoplanetary systems. As the TOPS Program evolves, emphasis will shift toward intensive study of the discovered systems and of individual planets. Early stages of the TOPS Program can be undertaken with ground-based observations and space missions comparable in scale to those now being performed. In the long term, however, TOPS will become an ambitious program that challenges our capabilities and provides impetus for major space initiatives and new technologies.

Characteristics of the most intense lightning storm ever recorded at the CN Tower

NASA Astrophysics Data System (ADS)

Hussein, A. M.; Kazazi, S.; Anwar, M.; Yusouf, M.; Liatos, P.

2017-02-01

Lightning strikes to the CN Tower have been optically observed since 1978. In 1990, five independent systems started to operate to simultaneously record parameters of lightning strikes to the tower, including the time derivative of the current, the associated electric and magnetic fields, and the channel optical characteristics. On August 24, 2011, during an unusually severe lightning storm, video records showed that the CN Tower was struck with 52 lightning flashes within 84 min and 6.9 s. Thus, this storm produced, on average, a flash to the tower every 99 s. However, the CN Tower lightning current derivative measurement system only recorded 32 flashes, which were perfectly time-matched with 32 of the 52 video-recorded flashes. It is found that the current derivative measurement system recorded every video-recorded flash that contained at least one return stroke. Based on the analysis of video records, it is noted that each of the storm's 52 flashes contains an initial-stage current, proving that all flashes were upward initiated. This unique CN Tower storm - the most intense ever recorded at the tower - is here thoroughly analyzed, based on video and current records. The inter-flash time within the storm is found to vary between 10.6 s and 274 s, with an overall average of 98 s. It is also found that the inter-flash time between successive non-return-stroke flashes is on average 64% longer than that for successive flashes containing return strokes. Statistical analysis of video and current data clearly reveals that the time duration of flashes containing initial-stage currents and return strokes is on average 27% longer than that of flashes that only have initial-stage currents. Furthermore, it is important to note that the time duration of the initial-stage current in flashes containing no return strokes is on average 76% longer than that in flashes containing return strokes. Therefore, it is possible to conclude that if the time duration of the initial-stage current in a flash is long enough, resulting in large charge transfer, then there is less probability of having return strokes following it. The 32 current-recorded flashes contain a total of 156 return strokes, with an average multiplicity of 4.875. It is worth mentioning that during one decade, 1992-2001, the CN Tower current derivative measurement system only recorded 478 return strokes, demonstrating that the number of return strokes recorded at the tower within about 84 min is close to one third of those recorded at the tower during one decade. This finding clearly shows the great value and rarity of the presented extensive lightning current derivative data. Only one of the 32 current-recorded flashes is proved to be positive with a single return stroke. Based on current records, out of a total of 124 inter-stroke time intervals, 94% are found to be within 200 ms, with an overall inter-stroke time average of 68.1 ms. The maximum inter-stroke time recorded during this storm is 726.3 ms, the longest ever recorded at the CN Tower.

Direct current hybrid breakers: A design and its realization

NASA Astrophysics Data System (ADS)

Atmadji, Ali Mahfudz Surya

2000-12-01

The use of semiconductors for electric power circuit breakers instead of conventional breakers remains a utopia when designing fault current interrupters for high power networks. The major problems concerning power semiconductor circuit breakers are the excessive heat losses and their sensitivity to transients. However, conventional breakers are capable of dealing with such matters. A combination of the two methods, or so-called `hybrid breakers', would appear to be a solution; however, hybrid breakers use separate parallel branches for conducting the main current and interrupting the short-circuit current. Such breakers are intended for protecting direct current (DC) traction systems. In this thesis hybrid switching techniques for current limitation and purely solidstate current interruption are investigated for DC breakers. This work analyzes the transient behavior of hybrid breakers and compares their operations with conventional breakers and similar solid-state devices in DC systems. Therefore a hybrid breaker was constructed and tested in a specially designed high power test circuit. A vacuum breaker was chosen as the main breaker in the main conducting path; then a commutation path was connected across the vacuum breaker where it provided current limitation and interruption. The commutation path operated only during any current interruption and the process required additional circuits. These included a certain energy storage, overvoltage suppressor and commutation switch. So that when discharging this energy, a controlled counter-current injection could be produced. That counter-current opposed the main current in the breaker by superposition in order to create a forced current-zero. One-stage and two-stage commutation circuits have been treated extensively. This study project contains both theoretical and experimental investigations. A direct current shortcircuit source was constructed capable of delivering power equivalent to a fault. It supplied a direct voltage of 1kVDC which was rectified having been obtained from a 3-phase lOkV/380V supply. The source was successfully tested to deliver a fault current of 7kA with a time constant of 5ms. The hybrid breaker that was developed could provide protection for 750VDC traction systems. The breaker was equipped with a fault- recognizing circuit based on a current level triggering. An electronic circuit was built for this need and was included in the system. It monitored the system continuously and took action by generating trip signals when a fault was recognized. Interruption was followed by a suitable timing of the fast contact separation in the main breaker and the current-zero creation. An electrodynamically driven mechanism was successfully tested having a dead-time of 300μs to separate the main breaker contacts. Furthermore, a maximum peak current injection of RA at a frequency of 500Hz could be obtained in order to produce an artificial current-zero in the vacuum breaker. A successful current interruption with a prospective value of RA was achieved by the hybrid switching technique. In addition, measures were taken to prevent overvoltages. Experimentally, the concept of a hybrid breaker was compared with the functioning of all mechanical (air breaker) and all electronical (IGCT breaker) versions. Although a single stage interrupting method was verified experimentally, two two-stage interrupting methods were analyzed theoretically.

Launching Payloads Into Orbit at Relatively Low Cost

NASA Technical Reports Server (NTRS)

Wilcox, Brian

2007-01-01

A report proposes the development of a system for launching payloads into orbit at about one-fifth the cost per unit payload weight of current systems. The PILOT system was a solid-fuel, aerodynamically spun and spin-stabilized, five-stage rocket with onboard controls including little more than an optoelectronic horizon sensor and a timer for triggering the second and fifth stages, respectively. The proposal calls for four improvements over the PILOT system to enable control of orbital parameters: (1) the aerodynamic tipover of the rocket at the top of the atmosphere could be modeled as a nonuniform gyroscopic precession and could be controlled by selection of the initial rocket configuration and launch conditions; (2) the attitude of the rocket at the top of the first-stage trajectory could be measured by use of radar tracking or differential Global Positioning System receivers to determine when to trigger the second stage; (3) the final-stage engines could be configured around the payload to enhance spin stabilization during a half-orbit coast up to apoapsis where the final stage would be triggered; and (4) the final payload stage could be equipped with a "beltline" of small thrusters for correcting small errors in the trajectory as measured by an off-board tracking subsystem.

Development of a hydraulic model and flood-inundation maps for the Wabash River near the Interstate 64 Bridge near Grayville, Illinois

USGS Publications Warehouse

Boldt, Justin A.

2018-01-16

A two-dimensional hydraulic model and digital flood‑inundation maps were developed for a 30-mile reach of the Wabash River near the Interstate 64 Bridge near Grayville, Illinois. The flood-inundation maps, which can be accessed through the U.S. Geological Survey (USGS) Flood Inundation Mapping Science web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Wabash River at Mount Carmel, Ill (USGS station number 03377500). Near-real-time stages at this streamgage may be obtained on the internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service (AHPS) at http://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS AHPS site MCRI2). The NWS AHPS forecasts peak stage information that may be used with the maps developed in this study to show predicted areas of flood inundation.Flood elevations were computed for the Wabash River reach by means of a two-dimensional, finite-volume numerical modeling application for river hydraulics. The hydraulic model was calibrated by using global positioning system measurements of water-surface elevation and the current stage-discharge relation at both USGS streamgage 03377500, Wabash River at Mount Carmel, Ill., and USGS streamgage 03378500, Wabash River at New Harmony, Indiana. The calibrated hydraulic model was then used to compute 27 water-surface elevations for flood stages at 1-foot (ft) intervals referenced to the streamgage datum and ranging from less than the action stage (9 ft) to the highest stage (35 ft) of the current stage-discharge rating curve. The simulated water‑surface elevations were then combined with a geographic information system digital elevation model, derived from light detection and ranging data, to delineate the area flooded at each water level.The availability of these maps, along with information on the internet regarding current stage from the USGS streamgage at Mount Carmel, Ill., and forecasted stream stages from the NWS AHPS, provides emergency management personnel and residents with information that is critical for flood-response activities such as evacuations and road closures, as well as for postflood recovery efforts.

Development of a Low-Power CO2 Removal and Compression System for Closed-Loop Air Revitalization in Future Spacecraft

NASA Technical Reports Server (NTRS)

Mulloth, Lila M.; Rosen, Micha; Affleck, David; LeVan, M. Douglas; Moate, Joe R.

2005-01-01

The current CO2 removal technology of NASA is very energy intensive and contains many non-optimized subsystems. This paper discusses the design and prototype development of a two-stage CO2 removal and compression system that will utilize much less power than NASA s current CO2 removal technology. This integrated system contains a Nafion membrane followed by a residual water adsorber that performs the function of the desiccant beds in the four-bed molecular sieve (4BMS) system of the International Space Station (ISS). The membrane and the water adsorber are followed by a two-stage CO2 removal and compression subsystem that satisfies the operations of the CO2 adsorbent beds of the 4BMS aid the interface compressor for the Sabatier reactor connection. The two-stage compressor will utilize the principles of temperature-swing adsorption (TSA) compression technology for CO2 removal and compression. The similarities in operation and cycle times of the CO2 removal (first stage) and compression (second stage) operations will allow thermal coupling of the processes to maximize the efficiency of the system. In addition to the low-power advantage, this processor will maintain a lower CO2 concentration in the cabin than that can be achieved by the existing CO2 removal systems. The compact, consolidated, configuration of membrane gas dryer and CO2 separator and compressor will allow continuous recycling of humid air in the cabin and supply of compressed CO2 to the reduction unit for oxygen recovery. The device has potential application to the International Space Station and future, long duration, transit, and planetary missions.

Design of a three-phase, 15-kilovolt-ampere static inverter for motor-starting a Brayton space power system

NASA Technical Reports Server (NTRS)

Frye, R. J.; Birchenough, A. G.

1971-01-01

The design of a three-phase, 400-Hz, 15-kVA static inverter for motor-starting the 2- to 15-kWe Brayton electrical space power system is described. The inverter operates from a nominal 56-V dc source to provide a 28-V, rms, quasi-square-wave output. The inverter is capable of supplying a 200-A peak current. Integrated circuitry is used to generate the three-phase, 400-Hz reference signals. Performance data for a drive stage that improves switching speed and provides efficient operation over a range of output current and drive supply voltage are presented. A transformerless, transistor output stage is used.

Ratcheting Strain and Microstructure Evolution of AZ31B Magnesium Alloy under a Tensile-Tensile Cyclic Loading

PubMed Central

Wang, Denghui; Wang, Wenxian; Zhou, Jun; He, Xiuli; Dong, Peng; Zhang, Hongxia; Sun, Liyong

2018-01-01

In this paper, studies were conducted to investigate the deformation behavior and microstructure change in a hot-rolled AZ31B magnesium alloy during a tensile-tensile cyclic loading. The relationship between ratcheting effect and microstructure change was discussed. The ratcheting effect in the material during current tensile-tensile fatigue loading exceeds the material’s fatigue limit and the development of ratcheting strain in the material experienced three stages: initial sharp increase stage (Stage I); steady stage (Stage II); and final abrupt increase stage (Stage III). Microstructure changes in Stage I and Stage II are mainly caused by activation of basal slip system. The Extra Geometrically Necessary Dislocations (GNDs) were also calculated to discuss the relationship between the dislocation caused by the basal slip system and the ratcheting strain during the cyclic loading. In Stage III, both the basal slip and the {11−20} twins are found active during the crack propagation. The fatigue crack initiation in the AZ31B magnesium alloy is found due to the basal slip and the {11−20} tensile twins. PMID:29597278

Ratcheting Strain and Microstructure Evolution of AZ31B Magnesium Alloy under a Tensile-Tensile Cyclic Loading.

PubMed

Yan, Zhifeng; Wang, Denghui; Wang, Wenxian; Zhou, Jun; He, Xiuli; Dong, Peng; Zhang, Hongxia; Sun, Liyong

2018-03-28

In this paper, studies were conducted to investigate the deformation behavior and microstructure change in a hot-rolled AZ31B magnesium alloy during a tensile-tensile cyclic loading. The relationship between ratcheting effect and microstructure change was discussed. The ratcheting effect in the material during current tensile-tensile fatigue loading exceeds the material's fatigue limit and the development of ratcheting strain in the material experienced three stages: initial sharp increase stage (Stage I); steady stage (Stage II); and final abrupt increase stage (Stage III). Microstructure changes in Stage I and Stage II are mainly caused by activation of basal slip system. The Extra Geometrically Necessary Dislocations (GNDs) were also calculated to discuss the relationship between the dislocation caused by the basal slip system and the ratcheting strain during the cyclic loading. In Stage III, both the basal slip and the {11-20} twins are found active during the crack propagation. The fatigue crack initiation in the AZ31B magnesium alloy is found due to the basal slip and the {11-20} tensile twins.

Neptune Orbiters Utilizing Solar and Radioisotope Electric Propulsion

NASA Technical Reports Server (NTRS)

Fiehler, Douglas I.; Oleson, Steven R.

2004-01-01

In certain cases, Radioisotope Electric Propulsion (REP), used in conjunction with other propulsion systems, could be used to reduce the trip times for outer planetary orbiter spacecraft. It also has the potential to improve the maneuverability and power capabilities of the spacecraft when the target body is reached as compared with non-electric propulsion spacecraft. Current missions under study baseline aerocapture systems to capture into a science orbit after a Solar Electric Propulsion (SEP) stage is jettisoned. Other options under study would use all REP transfers with small payloads. Compared to the SEP stage/Aerocapture scenario, adding REP to the science spacecraft as well as a chemical capture system can replace the aerocapture system but with a trip time penalty. Eliminating both the SEP stage and the aerocapture system and utilizing a slightly larger launch vehicle, Star 48 upper stage, and a combined REP/Chemical capture system, the trip time can nearly be matched while providing over a kilowatt of science power reused from the REP maneuver. A Neptune Orbiter mission is examined utilizing single propulsion systems and combinations of SEP, REP, and chemical systems to compare concepts.

Study of extraterrestrial disposal of radioactive wastes. Part 1: Space transportation and destination considerations for extraterrestrial disposal of radioactive wastes. [feasibility of using space shuttle

NASA Technical Reports Server (NTRS)

Thompson, R. L.; Ramler, J. R.; Stevenson, S. M.

1974-01-01

A feasibility study of extraterrestrial disposal of radioactive waste is reported. This report covers the initial work done on only one part of the NASA study, that evaluates and compares possible space destinations and space transportation systems. The currently planned space shuttle was found to be more cost effective than current expendable launch vehicles by about a factor of 2. The space shuttle requires a third stage to perform the waste disposal missions. Depending on the particular mission, this third stage could be either a reusable space tug or an expendable stage such as a Centaur.

From Particular to Popular: Facilitating EFL Mobile-Supported Cooperative Reading

ERIC Educational Resources Information Center

Lan, Yu-Ju; Sung, Yao-Ting; Chang, Kuo-En

2013-01-01

This paper reports the results of an action research-based study that adapted a mobile-supported cooperative reading system into regular English as a foreign language (EFL) classes at one Taiwanese elementary school. The current study was comprised of two stages: adaptation and evaluation. During the adaptation stage, a mobile-supported…

Proposal of a new staging system for intrahepatic cholangiocarcinoma: Analysis of surgical patients from a nationwide survey of the Liver Cancer Study Group of Japan.

PubMed

Sakamoto, Yoshihiro; Kokudo, Norihiro; Matsuyama, Yutaka; Sakamoto, Michiie; Izumi, Namiki; Kadoya, Masumi; Kaneko, Shuichi; Ku, Yonson; Kudo, Masatoshi; Takayama, Tadatoshi; Nakashima, Osamu

2016-01-01

In the current American Joint Committee on Cancer/International Union Against Cancer staging system (seventh edition) for intrahepatic cholangiocarcinoma (ICC), tumor size was excluded, and periductal invasion was added as a new tumor classification-defining factor. The objective of the current report was to propose a new staging system for ICC that would be better for stratifying the survival of patients based on data from the nationwide Liver Cancer Study Group of Japan database. Of 756 patients who underwent surgical resection for ICC between 2000 and 2005, multivariate analyses of the clinicopathologic factors of 419 patients who had complete data sets were performed to elucidate relevant factors for inclusion in a new tumor classification and staging system. Overall survival data were best stratified using a cutoff value of 2 cm using a minimal P value approach to discriminate patient survival. The 5-year survival rate of 15 patients who had ICC measuring ≤ 2 cm in greatest dimension without lymph node metastasis or vascular invasion was 100%, and this cohort was defined as T1. Multivariate analysis of prognostic factors for 267 patients with lymph node-negative and metastasis-negative (N0M0) disease indicated that the number of tumors, the presence arterial invasion, and the presence major biliary invasion were independent and significant prognostic factors. The proposed new system, which included tumor number, tumor size, arterial invasion, and major biliary invasion for tumor classification, provided good stratification of overall patient survival according to disease stage. Macroscopic periductal invasion was associated with major biliary invasion and an inferior prognosis. The proposed new staging system, which includes a tumor cutoff size of 2 cm and major biliary invasion, may be useful for assigning patients to surgery. © 2015 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

Current Source Logic Gate

NASA Technical Reports Server (NTRS)

Krasowski, Michael J. (Inventor); Prokop, Norman F. (Inventor)

2017-01-01

A current source logic gate with depletion mode field effect transistor ("FET") transistors and resistors may include a current source, a current steering switch input stage, and a resistor divider level shifting output stage. The current source may include a transistor and a current source resistor. The current steering switch input stage may include a transistor to steer current to set an output stage bias point depending on an input logic signal state. The resistor divider level shifting output stage may include a first resistor and a second resistor to set the output stage point and produce valid output logic signal states. The transistor of the current steering switch input stage may function as a switch to provide at least two operating points.

ORCHID - a computer simulation of the reliability of an NDE inspection system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moles, M.D.C.

1987-03-01

CANDU pressurized heavy water reactors contain several hundred horizontally-mounted zirconium alloy pressure tubes. Following a pressure tube failure, a pressure tube inspection system called CIGARette was rapidly designed, manufactured and put in operation. Defects called hydride blisters were found to be the cause of the failure, and were detected using a combination of eddy current and ultrasonic scans. A number of improvements were made to CIGARette during the inspection period. The ORCHID computer program models the operation of the delivery system, eddy current and ultrasonic systems by imitating the on-reactor decision-making procedure. ORCHID predicts that during the early stage ofmore » development, less than one blistered tube in three would be detected, while less than one in two would be detected in the middle development stage. However, ORCHID predicts that during the late development stage, probability of detection will be over 90%, primarily due to the inclusion of axial ultrasonic scans (a procedural modification). Rotational and axial slip could severely reduce probability of detection. Comparison of CIGARette's inspection data with ORCHID's predictions indicate that the latter are compatible with the actual inspection results, through the numbers are small and data uncertain. It should be emphasized that the CIGARette system has been essentially replaced with the much more reliable CIGAR system.« less

Robotic-assisted surgery in ophthalmology.

PubMed

de Smet, Marc D; Naus, Gerrit J L; Faridpooya, Koorosh; Mura, Marco

2018-05-01

Provide an overview of the current landscape of robotics in ophthalmology, including the pros and cons of system designs, the clinical development path, and the likely future direction of the field. Robots designed for eye surgery should meet certain basic requirements. Three designs are currently being developed: smart surgical tools such as the steady hand, comanipulation devices and telemanipulators using either a fixed or virtual remote center of motion. Successful human intraocular surgery is being performed using the Preceyes surgical system. Another telemanipulation robot, the da Vinci Surgical System, has been used to perform a pterygium repair in humans and was successful in ex-vivo corneal surgery despite its nonophthalmic design. Apart from Preceyes' BV research platform, none of the currently eye-specific systems has reached a commercial stage. Systems are likely to evolve from robotic assistance during specific procedural steps to semiautonomous surgery, as smart sensors are introduced to enhance the basic functionalities of robotic systems. Robotics is still in its infancy in ophthalmology but is rapidly reaching a stage wherein it will be introduced into everyday ophthalmic practice. It will most likely be introduced first for demanding vitreo-retinal procedures, followed by anterior segment applications.

Flood-inundation maps for the Big Blue River at Shelbyville, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.

2017-02-13

Digital flood-inundation maps for a 4.1-mile reach of the Big Blue River at Shelbyville, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The floodinundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at https://water. usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Big Blue River at Shelbyville, Ind. (station number 03361500). Near-real-time stages at this streamgage may be obtained from the USGS National Water Information System at https://waterdata. usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at https://water.weather.gov/ ahps/, which also forecasts flood hydrographs at this site (SBVI3). Flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relation at the Big Blue River at Shelbyville, Ind., streamgage. The calibrated hydraulic model was then used to compute 12 water-surface profiles for flood stages referenced to the streamgage datum and ranging from 9.0 feet, or near bankfull, to 19.4 feet, the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar] data having a 0.98-foot vertical accuracy and 4.9-foot horizontal resolution) to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage at the Big Blue River at Shelbyville, Ind., and forecasted stream stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post-flood recovery efforts.

Falls from height during the floor slab formwork of buildings: current situation in Spain.

PubMed

Adam, Jose M; Pallarés, Francisco J; Calderón, Pedro A

2009-01-01

One of the phases with the highest risk of falls from a height in the construction of a building is during the floor slab formwork stage. This paper analyzes this particular risk, as well as the most frequently used fall-protection systems. A survey was carried out to define the current situation in Spain with regard to falls from a height during floor slab formwork and the fall-protection systems used to prevent such a risk. The results of the survey clarified the current situation in Spain with regard to this risk, and made it clear that there is considerable risk of falling from a height during the floor slab formwork stage. All the safety systems analyzed presented a series of weak points that should be studied in detail before they can be used on building sites. The risk of falling associated with floor slab formwork and the most frequently used protection systems are analyzed. As no research had been carried out to date on this type of risk, we consider the research presented in this article to be a pioneer in the field.

Evolution of International Space Station GN&C System Across ISS Assembly Stages

NASA Technical Reports Server (NTRS)

Lee, Roscoe; Frank, K. D. (Technical Monitor)

1999-01-01

The Guidance Navigation and Control (GN&C) system for the International Space Station is initially implemented by the Functional Cargo Block (FGB) which was built by the Khrunichev Space Center under direct contract to Boeing. This element (Stage 1A/R) was launched on 20 November 1998 and is currently operating on-orbit. The components and capabilities of the FGB Motion Control System (MCS) are described. The next ISS element, which has GN&C functionality will be the Service Module (SM) built by Rocket Space Corporation-Energia. This module is scheduled for launch (Stage 1R) in early 2000. Following activation of the SM GN&C system, the FGB MCS is deactivated and no longer used. The components and capabilities of the SM GN&C system are described. When a Progress vehicle is attached to the ISS it can be used for reboost operations, based on commands provided by the Mission Control Center-Moscow. When a data connection is implemented between the SM and the Progress, the SM can command the Progress thrusters for attitude control and reboosts. On Stage 5A, the U.S. GN&C system will become activated when the U.S. Laboratory is de loyed and installed (launch schedule is currently TBD). The U.S. GN&C system provides non-propulsive control capabilities to support micro-gravity operations and minimize the use of propellant for attitude control, and an independent capability for determining the ISS state vector, attitude, attitude rate. and time.. The components and capabilities of the U.S. GN&C system are described and the interactions between the U.S. and Russian Segment GN&C systems are also described.

Reduced Boil-Off System Sizing

NASA Technical Reports Server (NTRS)

Guzik, Monica C.; Plachta, David W.; Feller, Jeffrey R.

2015-01-01

NASA is currently developing cryogenic propellant storage and transfer systems for future space exploration and scientific discovery missions by addressing the need to raise the technology readiness level of cryogenic fluid management technologies. Cryogenic propellants are baselined in many propulsion systems due to their inherently high specific impulse; however, their low boiling points can cause substantial boil-off losses over time. Recent efforts such as the Reduced Boil-off Testing and the Active Thermal Control Scaling Study provide important information on the benefit of an active cooling system applied to LH2 propellant storage. Findings show that zero-boil off technologies can reduce overall mass in LH2 storage systems when low Earth orbit loiter periods extend beyond two months. A significant part of this mass reduction is realized by integrating two stages of cooling: a 20 K stage to intercept heat at the tank surface, and a 90 K stage to reduce the heat entering the less efficient 20 K stage. A missing element in previous studies, which is addressed in this paper, is the development of a direct method for sizing the 90 K cooling stage. Such a method requires calculation of the heat entering both the 90 K and 20 K stages as compared to the overall system masses, and is reliant upon the temperature distribution, performance, and unique design characteristics of the system in question. By utilizing the known conductance of a system without active thermal control, the heat being intercepted by a 90 K stage can be calculated to find the resultant lift and mass of each active thermal control stage. Integral to this is the thermal conductance of the cooling straps and the broad area cooling shield, key parts of the 90 K stage. Additionally, a trade study is performed to show the ability of the 90 K cooling stage to reduce the lift on the 20 K cryocooler stage, which is considerably less developed and efficient than 90 K cryocoolers.

System Support/Sustainment Plan Platform for the Defense Enterprise Accounting Management System (DEAMS)

DTIC Science & Technology

2006-12-01

warfighters requirements and identifies system performance short-comings over its life cycle. 15. NUMBER OF PAGES 89 14. SUBJECT TERMS Information...the system performs to warfighters requirements and identifies system performance short-comings over its life cycle. vi...3 II. DEFENSE ACQUISITION LIFE CYCLE CURRENT STAGE ANALYSIS.......5 A. INTRODUCTION

Gastritis: the histology report.

PubMed

Rugge, Massimo; Pennelli, Gianmaria; Pilozzi, Emanuela; Fassan, Matteo; Ingravallo, Giuseppe; Russo, Valentina M; Di Mario, Francesco

2011-03-01

Gastritis is defined as inflammation of the gastric mucosa. In histological terms, it is distinguishable into two main categories, i.e. non-atrophic and atrophic. In the gastric mucosa, atrophy is defined as the loss of appropriate glands. There are several etiological types of gastritis, their different etiology being related to different clinical manifestations and pathological features. Atrophic gastritis (resulting mainly from long-standing Helicobacter pylori infection) is a major risk factor for the onset of (intestinal type) gastric cancer. The extent and site of the atrophic changes correlate significantly with the cancer risk. The current format for histology reporting in cases of gastritis fails to establish an immediate link between gastritis phenotype and risk of malignancy. Building on current knowledge of the biology of gastritis, an international group of pathologists [Operative Link for Gastritis Assessment (OLGA)] has proposed a system for reporting gastritis in terms of its stage (the OLGA Staging System): this system places the histological phenotypes of gastritis on a scale of progressively increasing gastric cancer risk, from the lowest (Stage 0) to the highest (Stage IV). The aim of this tutorial is to provide unequivocal information on how to standardize histology reports on gastritis in diagnostic practice. Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd.. All rights reserved.

A Study of a Two Stage Maximum Power Point Tracking Control of a Photovoltaic System under Partially Shaded Insolation Conditions

NASA Astrophysics Data System (ADS)

Kobayashi, Kenji; Takano, Ichiro; Sawada, Yoshio

A photovoltaic array shows relatively low output power density, and has a greatly drooping Current-Voltage (I-V) characteristic. Therefore, Maximum Power Point Tracking (MPPT) control is used to maximize the output power of the array. Many papers have been reported in relation to MPPT. However, the Current-Power (I-P) curve sometimes shows multi-local maximum points mode under non-uniform insolation conditions. The operating point of the PV system tends to converge to a local maximum output point which is not the real maximal output point on the I-P curve. Some papers have been also reported, trying to avoid this difficulty. However most of those control systems become rather complicated. Then, the two stage MPPT control method is proposed in this paper to realize a relatively simple control system which can track the real maximum power point even under non-uniform insolation conditions. The feasibility of this control concept is confirmed for steady insolation as well as for rapidly changing insolation by simulation study using software PSIM and LabVIEW. In addition, simulated experiment confirms fundament al operation of the two stage MPPT control.

Flood-inundation maps for North Fork Salt Creek at Nashville, Indiana

USGS Publications Warehouse

Martin, Zachary W.

2017-11-13

Digital flood-inundation maps for a 3.2-mile reach of North Fork Salt Creek at Nashville, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science website at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding that correspond to selected water levels (stages) at the North Fork Salt Creek at Nashville, Ind., streamgage (USGS station number 03371650). Real-time stages at this streamgage may be obtained from the USGS National Water Information System at http://waterdata.usgs.gov/nwis or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also shows observed USGS stages at the same site as the USGS streamgage (NWS site NFSI3).Flood profiles were computed for the stream reach by means of a one-dimensional, step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current (2015) stage-discharge rating at the USGS streamgage 03371650, North Fork Salt Creek at Nashville, Ind. The hydraulic model was then used to compute 12 water-surface profiles for flood stages at 1-foot (ft) intervals, except for the highest profile of 22.9 ft, referenced to the streamgage datum ranging from 12.0 ft (the NWS “action stage”) to 22.9 ft, which is the highest stage of the current (2015) USGS stage-discharge rating curve and 1.9 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from light detection and ranging data having a 0.98-ft vertical accuracy and 4.9-ft horizontal resolution) to delineate the area flooded at each stage.The availability of these maps, along with information regarding current stage from the USGS streamgage, will provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for postflood recovery efforts.

Optimization of a novel enzyme treatment process for early-stage processing of sheepskins.

PubMed

Lim, Y F; Bronlund, J E; Allsop, T F; Shilton, A N; Edmonds, R L

2010-01-01

An enzyme treatment process for early-stage processing of sheepskins has been previously reported by the Leather and Shoe Research Association of New Zealand (LASRA) as an alternative to current industry operations. The newly developed process had marked benefits over conventional processing in terms of a lowered energy usage (73%), processing time (47%) as well as water use (49%), but had been developed as a "proof of principle''. The objective of this work was to develop the process further to a stage ready for adoption by industry. Mass balancing was used to investigate potential modifications for the process based on the understanding developed from a detailed analysis of preliminary design trials. Results showed that a configuration utilising a 2 stage counter-current system for the washing stages and segregation and recycling of enzyme float prior to dilution in the neutralization stage was a significant improvement. Benefits over conventional processing include a reduction of residual TDS by 50% at the washing stages and 70% savings on water use overall. Benefits over the un-optimized LASRA process are reduction of solids in product after enzyme treatment and neutralization stages by 30%, additional water savings of 21%, as well as 10% savings of enzyme usage.

42 CFR 414.65 - Payment for telehealth services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... professional service via an interactive telecommunications system is made according to the following... psychotherapy, psychiatric diagnostic interview examination, pharmacologic management, end-stage renal disease... intervention services furnished via an interactive telecommunications system is equal to the current fee...

The Integration of Children with Disabilities into Regular Schools. A Naturalistic Study. Stage 2 Report.

ERIC Educational Resources Information Center

Center, Yola; And Others

The study used a multiple case study method to investigate the quality of the educational and social experiences of elementary-level and secondary-level children with disabilities currently integrated within the Australian regular school system. This second stage of the study used for its sample 23 children with intellectual disabilities, 18 with…

Current interruption in inductive storage systems with inertial current source

NASA Astrophysics Data System (ADS)

Vitkovitsky, I. M.; Conte, D.; Ford, R. D.; Lupton, W. H.

1980-03-01

Utilization of inertial current source inductive storage with high power output requires a switch with short opening time. This switch must operate as a circuit breaker, i.e., be capable to carry the current for a time period characteristic of inertial systems, such as homopolar generators. For reasonable efficiency, its opening time must be fast to minimize the energy dissipated in downstream fuse stages required for any additional pulse compression. A switch that satisfies these criteria, as well as other requirements such as that for high voltage operation associated with high power output, is an explosively driven switch consisting of large number of gaps arranged in series. The performance of this switch in limiting and/or interrupting currents produced by large generators has been studied. Single switch modules were designed and tested for limiting the commutating current output of 1 MW, 60 Hz, generator and 500 KJ capacitor banks. Current limiting and commutation were evaluated, using these sources, for currents ranging up to 0.4 MA. The explosive opening of the switch was found to provide an effective first stage for further pulse compression. It opens in tens of microseconds, commutates current at high efficiency ( = 905) recovers very rapidly over a wide range of operating conditions.

Two-stage commercial evaluation of engineering systems production projects for high-rise buildings

NASA Astrophysics Data System (ADS)

Bril, Aleksander; Kalinina, Olga; Levina, Anastasia

2018-03-01

The paper is devoted to the current and debatable problem of methodology of choosing the effective innovative enterprises for venture financing. A two-stage system of commercial innovation evaluation based on the UNIDO methodology is proposed. Engineering systems account for 25 to 40% of the cost of high-rise residential buildings. This proportion increases with the use of new construction technologies. Analysis of the construction market in Russia showed that the production of internal engineering systems elements based on innovative technologies has a growth trend. The production of simple elements is organized in small enterprises on the basis of new technologies. The most attractive for development is the use of venture financing of small innovative business. To improve the efficiency of these operations, the paper proposes a methodology for a two-stage evaluation of small business development projects. A two-stage system of commercial evaluation of innovative projects allows creating an information base for informed and coordinated decision-making on venture financing of enterprises that produce engineering systems elements for the construction business.

Management of Early Stage, High-Risk Endometrial Carcinoma: Preoperative and Surgical Considerations

PubMed Central

Pettigrew, Gaetan

2013-01-01

Endometrial cancer is the most common gynecologic malignancy in the developed world. Most cases are diagnosed at an early stage and have low-grade histology, portending an overall excellent prognosis. There exists a subgroup of patients with early, high-risk disease, whose management remains controversial, as current data is clouded by inclusion of early stage tumors with different high-risk features for recurrence, unstandardized protocols for surgical staging, and an evolving staging system by which we are grouping these patients. Here, we present preoperative and intraoperative considerations that should be taken into account when planning surgical management for this population of patients. PMID:23878545

United States Air Force Computer-Aided Acquisition and Logistics Support (CALS). Logistics Support Analysis Current Environment. Volume 2

DOT National Transportation Integrated Search

1988-10-01

An analysis of the current environment within the Acquisition stage of the Weapon System Life Cycle Pertaining to the Logistics Support Analysis (LSA) process, the Logistics Support Analysis Record (LSAR), and other Logistics Support data was underta...

United States Air Force Computer-Aided Acquisition and Logistics Support (CALS). Logistics Support Analysis Current Environment. Volume 1

DOT National Transportation Integrated Search

1988-10-01

An analysis of the current environment within the Acquisition stage of the Weapon System Life Cycle Pertaining to the Logistics Support Analysis (LSA) process, the Logistics Support Analysis Record (LSAR), and other Logistics Support data was underta...

SSTO RLVs: More Global Reach? A Study of the Use of Single Stage to Orbit Reusable Launch Vehicles as Airlift Platforms.

DTIC Science & Technology

1996-11-01

Orbit ( SSTO ) Reusable Launch Vehicles (RLVs) are currently under cooperative development by NASA, the Air Force, and the aerospace industry in the pursuit...exploit these rapid transit technologies to advance ’Global Reach for America.’ The SSTO RLV is a single stage rocket that will be completely reusable...investigated to assess the projected capabilities and costs of the SSTO system. This paper reviews the proposed capabilities of the SSTO system, discusses

Esophageal cancer: anatomic particularities, staging, and imaging techniques.

PubMed

Encinas de la Iglesia, J; Corral de la Calle, M A; Fernández Pérez, G C; Ruano Pérez, R; Álvarez Delgado, A

2016-01-01

Cancer of the esophagus is a tumor with aggressive behavior that is usually diagnosed in advanced stages. The absence of serosa allows it to spread quickly to neighboring mediastinal structures, and an extensive lymphatic drainage network facilitates tumor spread even in early stages. The current TNM classification, harmonized with the classification for gastric cancer, provides new definitions for the anatomic classification, adds non-anatomic characteristics of the tumor, and includes tumors of the gastroesophageal junction. Combining endoscopic ultrasound, computed tomography, positron emission tomography, and magnetic resonance imaging provides greater accuracy in determining the initial clinical stage, and these imaging techniques play an essential role in the selection, planning, and evaluation of treatment. In this article, we review some particularities that explain the behavior of this tumor and we describe the current TNM staging system; furthermore, we discuss the different imaging tests available for its evaluation and include a diagnostic algorithm. Copyright © 2016 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

Perspectives on current tumor-node-metastasis (TNM) staging of cancers of the colon and rectum.

PubMed

Hu, Huankai; Krasinskas, Alyssa; Willis, Joseph

2011-08-01

Improvements in classifications of cancers based on discovery and validation of important histopathological parameters and new molecular markers continue unabated. Though still not perfect, recent updates of classification schemes in gastrointestinal oncology by the American Joint Commission on Cancer (tumor-node-metastasis [TNM] staging) and the World Health Organization further stratify patients and guide optimization of treatment strategies and better predict patient outcomes. These updates recognize the heterogeneity of patient populations with significant subgrouping of each tumor stage and use of tumor deposits to significantly "up-stage" some cancers; change staging parameters for subsets of IIIB and IIIC cancers; and introduce of several new subtypes of colon carcinomas. By the nature of the process, recent discoveries that are important to improving even routine standards of patient care, especially new advances in molecular medicine, are not incorporated into these systems. Nonetheless, these classifications significantly advance clinical standards and are welcome enhancements to our current methods of cancer reporting. Copyright © 2011 Elsevier Inc. All rights reserved.

Development and validation of a surgical-pathologic staging and scoring system for cervical cancer.

PubMed

Li, Shuang; Li, Xiong; Zhang, Yuan; Zhou, Hang; Tang, Fangxu; Jia, Yao; Hu, Ting; Sun, Haiying; Yang, Ru; Chen, Yile; Cheng, Xiaodong; Lv, Weiguo; Wu, Li; Zhou, Jin; Wang, Shaoshuai; Huang, Kecheng; Wang, Lin; Yao, Yuan; Yang, Qifeng; Yang, Xingsheng; Zhang, Qinghua; Han, Xiaobing; Lin, Zhongqiu; Xing, Hui; Qu, Pengpeng; Cai, Hongbing; Song, Xiaojie; Tian, Xiaoyu; Shen, Jian; Xi, Ling; Li, Kezhen; Deng, Dongrui; Wang, Hui; Wang, Changyu; Wu, Mingfu; Zhu, Tao; Chen, Gang; Gao, Qinglei; Wang, Shixuan; Hu, Junbo; Kong, Beihua; Xie, Xing; Ma, Ding

2016-04-12

Most cervical cancer patients worldwide receive surgical treatments, and yet the current International Federation of Gynecology and Obstetrics (FIGO) staging system do not consider surgical-pathologic data. We propose a more comprehensive and prognostically valuable surgical-pathologic staging and scoring system (SPSs). Records from 4,220 eligible cervical cancer cases (Cohort 1) were screened for surgical-pathologic risk factors. We constructed a surgical-pathologic staging and SPSs, which was subsequently validated in a prospective study of 1,104 cervical cancer patients (Cohort 2). In Cohort 1, seven independent risk factors were associated with patient outcome: lymph node metastasis (LNM), parametrial involvement, histological type, grade, tumor size, stromal invasion, and lymph-vascular space invasion (LVSI). The FIGO staging system was revised and expanded into a surgical-pathologic staging system by including additional criteria of LNM, stromal invasion, and LVSI. LNM was subdivided into three categories based on number and location of metastases. Inclusion of all seven prognostic risk factors improves practical applicability. Patients were stratified into three SPSs risk categories: zero-, low-, and high-score with scores of 0, 1 to 3, and ≥4 (P=1.08E-45; P=6.15E-55). In Cohort 2, 5-year overall survival (OS) and disease-free survival (DFS) outcomes decreased with increased SPSs scores (P=9.04E-15; P=3.23E-16), validating the approach. Surgical-pathologic staging and SPSs show greater homogeneity and discriminatory utility than FIGO staging. Surgical-pathologic staging and SPSs improve characterization of tumor severity and disease invasion, which may more accurately predict outcome and guide postoperative therapy.

Feasibility of Air Levitated Surface Stage for Lithography Tool

NASA Astrophysics Data System (ADS)

Tanaka, Keiichi

The application of light-weight drive technology into the lithography stage has been the current state of art because of minimization of power loss. The purpose of this article is to point out the so-called, "surface stage" which is composed of Lorentz forced 3 DOF (Degree Of Freedom) planar motor (x, y and theta z), air levitation (bearing) system and motor cooling system, is the most balanced concept for the next generation lithography through the verification of each component by manufacturing simple parts and test stand. This paper presents the design method and procedure, and experimental results of the air levitated surface stage which was conducted several years ago, however the author is convinced that the results are enough to adapt various developments of precision machining tool.

The Quality Assurance System for Ontario Postsecondary Education: 2010-2014

ERIC Educational Resources Information Center

Liu, Qin

2015-01-01

The period of 2010 to 2014 marked a relatively stable stage in the evolving quality assurance system for Ontario postsecondary education, particularly following massive changes after 2000. The current system consists of three frameworks overseen respectively by three quality assurance agencies--the Ontario Universities Council on Quality…

Flood-inundation maps for the St. Marys River at Fort Wayne, Indiana

USGS Publications Warehouse

Menke, Chad D.; Kim, Moon H.; Fowler, Kathleen K.

2012-01-01

Digital flood-inundation maps for a 9-mile reach of the St. Marys River that extends from South Anthony Boulevard to Main Street at Fort Wayne, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Fort Wayne. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. Current conditions at the USGS streamgages in Indiana may be obtained from the National Water Information System: Web Interface. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system. The NWS forecasts flood hydrographs at many places that are often collocated at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, water-surface profiles were simulated for the stream reach by means of a hydraulic one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relation at the USGS streamgage 04182000 St. Marys River near Fort Wayne, Ind. The hydraulic model was then used to simulate 11 water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. A flood inundation map was generated for each water-surface profile stage (11 maps in all) so that for any given flood stage users will be able to view the estimated area of inundation. The availability of these maps along with current stage from USGS streamgages and forecasted stream stages from the NWS provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post flood recovery efforts.

Flood-inundation maps for the Wabash River at Lafayette, Indiana

USGS Publications Warehouse

Kim, Moon H.

2018-05-10

Digital flood-inundation maps for an approximately 4.8-mile reach of the Wabash River at Lafayette, Indiana (Ind.) were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science web site at https://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at USGS streamgage 03335500, Wabash River at Lafayette, Ind. Current streamflow conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the internet at https://waterdata.usgs.gov/in/nwis/uv?site_no=03335500. In addition, information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood-warning system (https://water.weather.gov/ahps/). The NWS AHPS forecasts flood hydrographs at many places that are often colocated with USGS streamgages, including the Wabash River at Lafayette, Ind. NWS AHPS-forecast peak-stage information may be used with the maps developed in this study to show predicted areas of flood inundation.For this study, flood profiles were computed for the Wabash River reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at USGS streamgage 03335500, Wabash River at Lafayette, Ind., and high-water marks from the flood of July 2003 (U.S. Army Corps of Engineers [USACE], 2007). The calibrated hydraulic model was then used to determine 23 water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a geographic information system digital elevation model derived from light detection and ranging to delineate the area flooded at each water level. The availability of these maps, along with internet information regarding current stage from the USGS streamgage 03335500, Wabash River at Lafayette, Ind., and forecasted high-flow stages from the NWS AHPS, will provide emergency management personnel and residents with information that is critical for flood-response activities such as evacuations and road closures, and for postflood recovery efforts.

Flood-inundation maps for the North Branch Elkhart River at Cosperville, Indiana

USGS Publications Warehouse

Kim, Moon H.; Johnson, Esther M.

2014-01-01

Digital flood-inundation maps for a reach of the North Branch Elkhart River at Cosperville, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the U.S. Army Corps of Engineers, Detroit District. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at USGS streamgage 04100222, North Branch Elkhart River at Cosperville, Ind. Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/in/nwis/uv?site_no=04100222. In addition, information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http:/water.weather.gov/ahps/). The NWS AHPS forecasts flood hydrographs at many places that are often colocated with USGS streamgages, including the North Branch Elkhart River at Cosperville, Ind. NWS AHPS-forecast peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. For this study, flood profiles were computed for the North Branch Elkhart River reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at USGS streamgage 04100222, North Branch Elkhart River at Cosperville, Ind., and preliminary high-water marks from the flood of March 1982. The calibrated hydraulic model was then used to determine four water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a geographic information system (GIS) digital elevation model (DEM, derived from Light Detection and Ranging [LiDAR]) in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage 04100222, North Branch Elkhart River at Cosperville, Ind., and forecast stream stages from the NWS AHPS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Flood-inundation maps for the East Fork White River near Bedford, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.

2014-01-01

Digital flood-inundation maps for an 1.8-mile reach of the East Fork White River near Bedford, Indiana (Ind.) were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selectedwater levels (stages) at USGS streamgage 03371500, East Fork White River near Bedford, Ind. Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/in/nwis/uv?site_no=03371500. In addition, information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages, including the East Fork White River near Bedford, Ind. NWS-forecasted peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. For this study, flood profiles were computed for the East Fork White River reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at USGS streamgage 03371500, East Fork White River near Bedford, Ind., and documented high-water marks from the flood of June 2008. The calibrated hydraulic model was then used to determine 20 water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a geographic information system (GIS) digital elevation model (DEM, derived from Light Detection and Ranging (LiDAR) data having a 0.593-foot vertical accuracy) in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage near Bedford, Ind., and forecasted stream stages from the NWS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for postflood recovery eforts.

Flood-Inundation Maps for Sugar Creek at Crawfordsville, Indiana

USGS Publications Warehouse

Martin, Zachary W.

2016-06-06

Digital flood-inundation maps for a 6.5-mile reach of Sugar Creek at Crawfordsville, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 03339500, Sugar Creek at Crawfordsville, Ind. Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS site CRWI3).Flood profiles were computed for the USGS streamgage 03339500, Sugar Creek at Crawfordsville, Ind., reach by means of a one-dimensional step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current stage-discharge rating at the USGS streamgage 03339500, Sugar Creek at Crawfordsville, Ind., and high-water marks from the flood of April 19, 2013, which reached a stage of 15.3 feet. The hydraulic model was then used to compute 13 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 4.0 ft (the NWS “action stage”) to 16.0 ft, which is the highest stage interval of the current USGS stage-discharge rating curve and 2 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar]) data having a 0.49-ft root mean squared error and 4.9-ft horizontal resolution) to delineate the area flooded at each stage.The availability of these maps, along with Internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

SPALAX new generation: New process design for a more efficient xenon production system for the CTBT noble gas network.

PubMed

Topin, Sylvain; Greau, Claire; Deliere, Ludovic; Hovesepian, Alexandre; Taffary, Thomas; Le Petit, Gilbert; Douysset, Guilhem; Moulin, Christophe

2015-11-01

The SPALAX (Système de Prélèvement Automatique en Ligne avec l'Analyse du Xénon) is one of the systems used in the International Monitoring System of the Comprehensive Nuclear Test Ban Treaty (CTBT) to detect radioactive xenon releases following a nuclear explosion. Approximately 10 years after the industrialization of the first system, the CEA has developed the SPALAX New Generation, SPALAX-NG, with the aim of increasing the global sensitivity and reducing the overall size of the system. A major breakthrough has been obtained by improving the sampling stage and the purification/concentration stage. The sampling stage evolution consists of increasing the sampling capacity and improving the gas treatment efficiency across new permeation membranes, leading to an increase in the xenon production capacity by a factor of 2-3. The purification/concentration stage evolution consists of using a new adsorbent Ag@ZSM-5 (or Ag-PZ2-25) with a much larger xenon retention capacity than activated charcoal, enabling a significant reduction in the overall size of this stage. The energy consumption of the system is similar to that of the current SPALAX system. The SPALAX-NG process is able to produce samples of almost 7 cm(3) of xenon every 12 h, making it the most productive xenon process among the IMS systems. Copyright © 2015 Elsevier Ltd. All rights reserved.

Design, simulation and construction of the Taban tokamak

NASA Astrophysics Data System (ADS)

H, R. MIRZAEI; R, AMROLLAHI

2018-04-01

This paper describes the design and construction of the Taban tokamak, which is located in Amirkabir University of Technology, Tehran, Iran. The Taban tokamak was designed for plasma investigation. The design, simulation and construction of essential parts of the Taban tokamak such as the toroidal field (TF) system, ohmic heating (OH) system and equilibrium field system and their power supplies are presented. For the Taban tokamak, the toroidal magnetic coil was designed to produce a maximum field of 0.7 T at R = 0.45 m. The power supply of the TF was a 130 kJ, 0–10 kV capacitor bank. Ripples of toroidal magnetic field at the plasma edge and plasma center are 0.2% and 0.014%, respectively. For the OH system with 3 kA current, the stray field in the plasma region is less than 40 G over 80% of the plasma volume. The power supply of the OH system consists of two stages, as follows. The fast bank stage is a 120 μF, 0–5 kV capacitor that produces 2.5 kA in 400 μs and the slow bank stage is 93 mF, 600 V that can produce a maximum of 3 kA. The equilibrium system can produce uniform magnetic field at plasma volume. This system’s power supply, like the OH system, consists of two stages, so that the fast bank stage is 500 μF, 800 V and the slow bank stage is 110 mF, 200 V.

High-Energy Two-Stage Pulsed Plasma Thruster

NASA Technical Reports Server (NTRS)

Markusic, Tom

2003-01-01

A high-energy (28 kJ per pulse) two-stage pulsed plasma thruster (MSFC PPT-1) has been constructed and tested. The motivation of this project is to develop a high power (approximately 500 kW), high specific impulse (approximately 10000 s), highly efficient (greater than 50%) thruster for use as primary propulsion in a high power nuclear electric propulsion system. PPT-1 was designed to overcome four negative characteristics which have detracted from the utility of pulsed plasma thrusters: poor electrical efficiency, poor propellant utilization efficiency, electrode erosion, and reliability issues associated with the use of high speed gas valves and high current switches. Traditional PPTs have been plagued with poor efficiency because they have not been operated in a plasma regime that fully exploits the potential benefits of pulsed plasma acceleration by electromagnetic forces. PPTs have generally been used to accelerate low-density plasmas with long current pulses. Operation of thrusters in this plasma regime allows for the development of certain undesirable particle-kinetic effects, such as Hall effect-induced current sheet canting. PPT-1 was designed to propel a highly collisional, dense plasma that has more fluid-like properties and, hence, is more effectively pushed by a magnetic field. The high-density plasma loading into the second stage of the accelerator is achieved through the use of a dense plasma injector (first stage). The injector produces a thermal plasma, derived from a molten lithium propellant feed system, which is subsequently accelerated by the second stage using mega-amp level currents, which eject the plasma at a speed on the order of 100 kilometers per second. Traditional PPTs also suffer from dynamic efficiency losses associated with snowplow loading of distributed neutral propellant. The twostage scheme used in PPT-I allows the propellant to be loaded in a manner which more closely approximates the optimal slug loading. Lithium propellant was chosen to test whether or not the reduced electrode erosion found in the Lithium Lorentz Force Accelerator (LiLFA) could also be realized in a pulsed plasma thruster. The use of the molten lithium dense plasma injector also eliminates the need for a gas valve and electrical switch; the injector design fulfills both roles, and uses no moving parts to provide, in principle, a highly reliable propellant feed and electrical switching system. Experimental results reported in this paper include: second-stage current traces, high-speed photographic and holographic imaging of the thruster exit plume, and internal mapping of the discharge chamber magnetic field from B-dot probe data. The magnetic field data is used to create a two-dimensional description of the evolution of the current sheet inside the thruster.

Nascom System Development Plan: System Description, Capabilities and Plans

NASA Technical Reports Server (NTRS)

1995-01-01

The NASA Communications (Nascom) System Development Plan (NSDP), reissued annually, describes the organization of Nascom, how it obtains communication services, its current systems, its relationship with other NASA centers and International Partner Agencies, some major spaceflight projects which generate significant operational communication support requirements, and major Nascom projects in various stages of development or implementation.

[Revision of the TNM Stage Grouping in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer].

PubMed

Ye, Bo; Zhao, Heng

2016-06-20

The currently adopted staging system for lung cancer is the seventh edition of the TNM staging edited by Union for International Cancer Control (UICC) in January, 2009. In recent years, with the advances of techniques in lung cancer diagnosis and the treatment trends towards precision treatment modalities such as individualized therapy and molecular targeted therapy, the survival and prognosis of lung cancer has been significantly improved. The old staging standard is difficult to satisfy the currentrapidly developing clinical needs. Therefore, the International Lung Cancer Research Society (International Association for the Study of Lung Cancer, IASLC) updated the stage of lung cancer in 2015, and the forthcoming eighth edition of the TNM Classification for Lung Cancer, which will be formally adopted in Jan. 2017, has been published in Journal of Thoracic Oncology. The new staging system has adopted 35 databases from 16 countries, including 94,708 cases treated between 1999 and 2010. The advantages of the new staging lies in its higher prognosis prediction and clinical guidance value.

Evaluation of the proposed International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancies Interest Group (ITMIG) staging revisions in thymic well-differentiated neuroendocrine carcinoma patients.

PubMed

Zhao, Yang; Shi, Jianxin; Fan, Limin; Yang, Jun; Hu, Dingzhong; Zhao, Heng

2016-02-01

In 2014, the International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancies Interest Group (ITMIG) launched a worldwide Tumor Node Metastasis (TNM) staging proposal for the next edition of thymic tumours. The objective of the current study was to evaluate the proposed new staging system specific to the thymic well-differentiated neuroendocrine carcinoma (TWDNC). From November 2003 to July 2014, 61 consecutive patients were enrolled in this study with pathologically confirmed TWDNC in Shanghai Chest Hospital. Clinical and pathological data were retrospectively reviewed. Survival analysis was performed using the Kaplan-Meier and log-rank tests. Validity evaluation was addressed by Cox proportional hazards regression model, after adjusting for potential confounders and visually assessing the distinction of curves generated based on the staging system of Masaoka-Koga and the proposed TNM ones. Thymic carcinoids made up 4% of total thymic tumours in our institution. The 5-year overall survival (OS) rate and the disease-free survival (DFS) rate were 72 and 41%, respectively. Neither Masaoka-Koga staging system nor the proposed TNM system showed ordered appropriateness visually in survival curves and the prognostic demarcation between stages was poor on both OS and DFS. The IASLC/ITMIG suggested that the TNM and Masaoka-Koga staging systems fail to predict the clinical course of TWDNC patients. Collaborative effort is needed in the future staging validation as ITMIG recommended. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

New J-STAGE system accelerates digitization and distribution of academic journals from Japan

NASA Astrophysics Data System (ADS)

Sato, Ryuichi; Kubota, Soichi; Aoyama, Kota; Tsuchiya, Eri; Miyagawa, Yoshiyuki

13 years have passed since J-STAGE was launched. At present no one could deny that its user interface and functions were already out of date comparing to foreign established e-journals. So JST has developed a new system called “J-STAGE3” in order to offer better usability and give powerful dissemination of academic papers from Japan. As the result of it, they will be able to enjoy the following things: 1) integration of two databases, Journal@rchive and J-STAGE, 2) new design/interface, 3) introduction of international standard XML format, 4) advanced subscription management, 5) saving cost of publishers, and 6) improving J-STAGE online submission and review system. At the end of March 2011, we conducted a market research on current status of digitization on Japanese society journals. The report told us that digitization ratio of those was 62% in total but it was 34% in humanities/social sciences. Or it was 92% in English journals and 55% in Japanese ones. It means that we need further promotion of digitization. In this paper, we discuss functions and direction of J-STAGE3 as well as our role in promotion of digitization of Japanese society journals.

Current state of total artificial heart therapy and introduction of the most important total artificial heart systems.

PubMed

Spiliopoulos, Sotirios; Hergesell, Vera; Wasler, Andrae; Dapunt, Otto

2018-06-14

Due to the declining instances of organ donation, total artificial heart (TAH) therapy is of increasing importance for the management of end-stage biventricular heart failure. We introduce the currently most important established and novel TAH systems (SynCardia, CARMAT, ReinHeart, BiVACOR), report clinical outcomes and discuss technical requirements for the successful implementation of TAH therapy as an alternative to cardiac transplantation.

Development of a low-cost biogas filtration system to achieve higher-power efficient AC generator

NASA Astrophysics Data System (ADS)

Mojica, Edison E.; Ardaniel, Ar-Ar S.; Leguid, Jeanlou G.; Loyola, Andrea T.

2018-02-01

The paper focuses on the development of a low-cost biogas filtration system for alternating current generator to achieve higher efficiency in terms of power production. A raw biogas energy comprises of 57% combustible element and 43% non-combustible elements containing carbon dioxide (36%), water vapor (5%), hydrogen sulfide (0.5%), nitrogen (1%), oxygen (0 - 2%), and ammonia (0 - 1%). The filtration system composes of six stages: stage 1 is the water scrubber filter intended to remove the carbon dioxide and traces of hydrogen sulfide; stage 2 is the silica gel filter intended to reduce the water vapor; stage 3 is the iron sponge filter intended to remove the remaining hydrogen sulfide; stage 4 is the sodium hydroxide solution filter intended to remove the elemental sulfur formed during the interaction of the hydrogen sulfide and the iron sponge and for further removal of carbon dioxide; stage 5 is the silica gel filter intended to further eliminate the water vapor gained in stage 4; and, stage 6 is the activated carbon filter intended to remove the carbon dioxide. The filtration system was able to lower the non-combustible elements by 72% and thus, increasing the combustible element by 54.38%. The unfiltered biogas is capable of generating 16.3 kW while the filtered biogas is capable of generating 18.6 kW. The increased in methane concentration resulted to 14.11% increase in the power output. The outcome resulted to better engine performance in the generation of electricity.

Assessing the Queuing Process Using Data Envelopment Analysis: an Application in Health Centres.

PubMed

Safdar, Komal A; Emrouznejad, Ali; Dey, Prasanta K

2016-01-01

Queuing is one of the very important criteria for assessing the performance and efficiency of any service industry, including healthcare. Data Envelopment Analysis (DEA) is one of the most widely-used techniques for performance measurement in healthcare. However, no queue management application has been reported in the health-related DEA literature. Most of the studies regarding patient flow systems had the objective of improving an already existing Appointment System. The current study presents a novel application of DEA for assessing the queuing process at an Outpatients' department of a large public hospital in a developing country where appointment systems do not exist. The main aim of the current study is to demonstrate the usefulness of DEA modelling in the evaluation of a queue system. The patient flow pathway considered for this study consists of two stages; consultation with a doctor and pharmacy. The DEA results indicated that waiting times and other related queuing variables included need considerable minimisation at both stages.

Energy Optimization for a Weak Hybrid Power System of an Automobile Exhaust Thermoelectric Generator

NASA Astrophysics Data System (ADS)

Fang, Wei; Quan, Shuhai; Xie, Changjun; Tang, Xinfeng; Ran, Bin; Jiao, Yatian

2017-11-01

An integrated starter generator (ISG)-type hybrid electric vehicle (HEV) scheme is proposed based on the automobile exhaust thermoelectric generator (AETEG). An eddy current dynamometer is used to simulate the vehicle's dynamic cycle. A weak ISG hybrid bench test system is constructed to test the 48 V output from the power supply system, which is based on engine exhaust-based heat power generation. The thermoelectric power generation-based system must ultimately be tested when integrated into the ISG weak hybrid mixed power system. The test process is divided into two steps: comprehensive simulation and vehicle-based testing. The system's dynamic process is simulated for both conventional and thermoelectric powers, and the dynamic running process comprises four stages: starting, acceleration, cruising and braking. The quantity of fuel available and battery pack energy, which are used as target vehicle energy functions for comparison with conventional systems, are simplified into a single energy target function, and the battery pack's output current is used as the control variable in the thermoelectric hybrid energy optimization model. The system's optimal battery pack output current function is resolved when its dynamic operating process is considered as part of the hybrid thermoelectric power generation system. In the experiments, the system bench is tested using conventional power and hybrid thermoelectric power for the four dynamic operation stages. The optimal battery pack curve is calculated by functional analysis. In the vehicle, a power control unit is used to control the battery pack's output current and minimize energy consumption. Data analysis shows that the fuel economy of the hybrid power system under European Driving Cycle conditions is improved by 14.7% when compared with conventional systems.

Low energy stage study. Volume 1: Executive summary. [propulsion system configurations for orbital launching of space shuttle payloads

NASA Technical Reports Server (NTRS)

1978-01-01

Cost effective approaches for placing automated payloads into circular and elliptical orbits using energy requirements significantly lower than that provided by the smallest, currently planned shuttle upper stage, SSUS-D, were investigated. Launch costs were derived using both NASA existing/planned launch approaches as well as new propulsion concepts meeting low-energy regime requirements. Candidate new propulsion approaches considered were solid (tandem, cluster, and controlled), solid/liquid combinations and all-liquid stages. Results show that the most economical way to deliver the 129 low energy payloads is basically with a new modular, short liquid bipropellant stage system for the large majority of the payloads. For the remainder of the payloads, use the shuttle with integral OMS and the Scout form for a few specialized payloads until the Shuttle becomes operational.

Nuclear Cryogenic Propulsion Stage Conceptual Design and Mission Analysis

NASA Technical Reports Server (NTRS)

Kos, Larry D.; Russell, Tiffany E.

2014-01-01

The Nuclear Cryogenic Propulsion Stage (NCPS) is an in-space transportation vehicle, comprised of three main elements, designed to support a long-stay human Mars mission architecture beginning in 2035. The stage conceptual design and the mission analysis discussed here support the current nuclear thermal propulsion going on within partnership activity of NASA and the Department of Energy (DOE). The transportation system consists of three elements: 1) the Core Stage, 2) the In-line Tank, and 3) the Drop Tank. The driving mission case is the piloted flight to Mars in 2037 and will be the main point design shown and discussed. The corresponding Space Launch System (SLS) launch vehicle (LV) is also presented due to it being a very critical aspect of the NCPS Human Mars Mission architecture due to the strong relationship between LV lift capability and LV volume capacity.

Development and validation of a surgical-pathologic staging and scoring system for cervical cancer

PubMed Central

Zhou, Hang; Tang, Fangxu; Jia, Yao; Hu, Ting; Sun, Haiying; Yang, Ru; Chen, Yile; Cheng, Xiaodong; Lv, Weiguo; Wu, Li; Zhou, Jin; Wang, Shaoshuai; Huang, Kecheng; Wang, Lin; Yao, Yuan; Yang, Qifeng; Yang, Xingsheng; Zhang, Qinghua; Han, Xiaobing; Lin, Zhongqiu; Xing, Hui; Qu, Pengpeng; Cai, Hongbing; Song, Xiaojie; Tian, Xiaoyu; Shen, Jian; Xi, Ling; Li, Kezhen; Deng, Dongrui; Wang, Hui; Wang, Changyu; Wu, Mingfu; Zhu, Tao; Chen, Gang; Gao, Qinglei; Wang, Shixuan; Hu, Junbo; Kong, Beihua; Xie, Xing; Ma, Ding

2016-01-01

Background Most cervical cancer patients worldwide receive surgical treatments, and yet the current International Federation of Gynecology and Obstetrics (FIGO) staging system do not consider surgical-pathologic data. We propose a more comprehensive and prognostically valuable surgical-pathologic staging and scoring system (SPSs). Methods Records from 4,220 eligible cervical cancer cases (Cohort 1) were screened for surgical-pathologic risk factors. We constructed a surgical-pathologic staging and SPSs, which was subsequently validated in a prospective study of 1,104 cervical cancer patients (Cohort 2). Results In Cohort 1, seven independent risk factors were associated with patient outcome: lymph node metastasis (LNM), parametrial involvement, histological type, grade, tumor size, stromal invasion, and lymph-vascular space invasion (LVSI). The FIGO staging system was revised and expanded into a surgical-pathologic staging system by including additional criteria of LNM, stromal invasion, and LVSI. LNM was subdivided into three categories based on number and location of metastases. Inclusion of all seven prognostic risk factors improves practical applicability. Patients were stratified into three SPSs risk categories: zero-, low-, and high-score with scores of 0, 1 to 3, and ≥4 (P=1.08E-45; P=6.15E-55). In Cohort 2, 5-year overall survival (OS) and disease-free survival (DFS) outcomes decreased with increased SPSs scores (P=9.04E-15; P=3.23E-16), validating the approach. Surgical-pathologic staging and SPSs show greater homogeneity and discriminatory utility than FIGO staging. Conclusions Surgical-pathologic staging and SPSs improve characterization of tumor severity and disease invasion, which may more accurately predict outcome and guide postoperative therapy. PMID:27014971

Keratoconus: The ABCD Grading System.

PubMed

Belin, M W; Duncan, J K

2016-06-01

To propose a new keratoconus classification/staging system that utilises current tomographic data and better reflects the anatomical and functional changes seen in keratoconus. A previously published normative database was reanalysed to generate both anterior and posterior average radii of curvature (ARC and PRC) taken from a 3.0 mm optical zone centred on the thinnest point of the cornea. Mean and standard deviations were recorded and anterior data were compared to the existing Amsler-Krumeich (AK) Classification. ARC, PRC, thinnest pachymetry and distance visual acuity were then used to construct a keratoconus classification. 672 eyes of 336 patients were analysed. Anterior and posterior values were 7.65 ± 0.236 mm and 6.26 ± 0.214 mm, respectively, and thinnest pachymetry values were 534.2 ± 30.36 µm. The ARC values were 2.63, 5.47 and 6.44 standard deviations from the mean values of stages 1-3 in the AK classification, respectively. PRC staging uses the same standard deviation gates. The pachymetric values differed by 4.42 and 7.72 standard deviations for stages 2 and 3, respectively. A new keratoconus staging incorporates anterior and posterior curvature, thinnest pachymetric values, and distance visual acuity and consists of stages 0-4 (5 stages). The proposed system closely matches the existing AK classification stages 1-4 on anterior curvature. As it incorporates posterior curvature and thickness measurements based on the thinnest point, rather than apical measurements, the new staging system better reflects the anatomical changes seen in keratoconus. Georg Thieme Verlag KG Stuttgart · New York.

Flood-inundation maps for the White River at Noblesville, Indiana

USGS Publications Warehouse

Martin, Zachary W.

2017-11-02

Digital flood-inundation maps for a 7.5-mile reach of the White River at Noblesville, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science website at https://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the White River at Noblesville, Ind., streamgage (USGS station number 03349000). Real-time stages at this streamgage may be obtained from the USGS National Water Information System at https://waterdata.usgs.gov/nwis or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at the same site as the USGS streamgage (NWS site NBLI3).Flood profiles were computed for the stream reach by means of a one-dimensional, step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current (2016) stage-discharge rating at the USGS streamgage 03349000, White River at Noblesville, Ind., and documented high-water marks from the floods of September 4, 2003, and May 6, 2017. The hydraulic model was then used to compute 15 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 10.0 ft (the NWS “action stage”) to 24.0 ft, which is the highest stage interval of the current (2016) USGS stage-discharge rating curve and 2 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from light detection and ranging data having a 0.98-ft vertical accuracy and 4.9-ft horizontal resolution) to delineate the area flooded at each stage.The availability of these maps, along with internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for postflood recovery efforts.

Flood-inundation maps for the St. Joseph River at Elkhart, Indiana

USGS Publications Warehouse

Martin, Zachary W.

2017-02-01

Digital flood-inundation maps for a 6.6-mile reach of the St. Joseph River at Elkhart, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at https://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind. Real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at https://waterdata.usgs.gov/nwis or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS site EKMI3).Flood profiles were computed for the stream reach by means of a one-dimensional, step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current stage-discharge rating at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind., and the documented high-water marks from the flood of March 1982. The hydraulic model was then used to compute six water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 23.0 ft (the NWS “action stage”) to 28.0 ft, which is the highest stage interval of the current USGS stage-discharge rating curve and 1 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar] data having a 0.49-ft root mean squared error and 4.9-ft horizontal resolution, resampled to a 10-ft grid) to delineate the area flooded at each stage.The availability of these maps, along with Internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Integrated Circuit Design of 3 Electrode Sensing System Using Two-Stage Operational Amplifier

NASA Astrophysics Data System (ADS)

Rani, S.; Abdullah, W. F. H.; Zain, Z. M.; N, Aqmar N. Z.

2018-03-01

This paper presents the design of a two-stage operational amplifier(op amp) for 3-electrode sensing system readout circuits. The designs have been simulated using 0.13μm CMOS technology from Silterra (Malaysia) with Mentor graphics tools. The purpose of this projects is mainly to design a miniature interfacing circuit to detect the redox reaction in the form of current using standard analog modules. The potentiostat consists of several op amps combined together in order to analyse the signal coming from the 3-electrode sensing system. This op amp design will be used in potentiostat circuit device and to analyse the functionality for each module of the system.

Space transportation and destination considerations for extraterrestrial disposal of radioactive waste

NASA Technical Reports Server (NTRS)

Zimmerman, A. V.; Thompson, R. L.; Lubick, R. J.

1973-01-01

A feasibility study is summarized of extraterrestrial (space) disposal of radioactive waste. The initial work on the evaluation and comparison of possible space destinations and launch vehicles is reported. Only current or planned space transportation systems were considered. The currently planned space shuttle was found to be more cost effective than current expendable launch vehicles, by about a factor of two. The space shuttle will require a third stage to perform the disposal missions. Depending on the particular mission this could be either a reusable space tug or an expendable stage such as a Centaur. Of the destinations considered, high earth orbits (between geostationary and lunar orbit altitudes), solar orbits (such as a 0.90 AU circular solar orbit) or a direct injection to solar system escape appear to be the best candidates. Both earth orbits and solar orbits have uncertainties regarding orbit stability and waste package integrity for times on the order of a million years.

Abridged republication of FIGO's staging classification for cancer of the ovary, fallopian tube, and peritoneum.

PubMed

Prat, Jaime

2015-10-01

Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3. The new staging includes a revision of stage III patients; assignment to stage IIIA1 is based on spread to the retroperitoneal lymph nodes without intraperitoneal dissemination. Extension of tumor from omentum to spleen or liver (stage IIIC) should be differentiated from isolated parenchymal metastases (stage IVB). © 2015 American Cancer Society.

Primary invasive squamous carcinoma of the vagina

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pride, G.L.; Schultz, A.E.; Chuprevich, T.W.

1979-02-01

Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised of 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%.more » Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV.« less

An adaptive modeling and simulation environment for combined-cycle data reconciliation and degradation estimation

NASA Astrophysics Data System (ADS)

Lin, Tsungpo

Performance engineers face the major challenge in modeling and simulation for the after-market power system due to system degradation and measurement errors. Currently, the majority in power generation industries utilizes the deterministic data matching method to calibrate the model and cascade system degradation, which causes significant calibration uncertainty and also the risk of providing performance guarantees. In this research work, a maximum-likelihood based simultaneous data reconciliation and model calibration (SDRMC) is used for power system modeling and simulation. By replacing the current deterministic data matching with SDRMC one can reduce the calibration uncertainty and mitigate the error propagation to the performance simulation. A modeling and simulation environment for a complex power system with certain degradation has been developed. In this environment multiple data sets are imported when carrying out simultaneous data reconciliation and model calibration. Calibration uncertainties are estimated through error analyses and populated to performance simulation by using principle of error propagation. System degradation is then quantified by performance comparison between the calibrated model and its expected new & clean status. To mitigate smearing effects caused by gross errors, gross error detection (GED) is carried out in two stages. The first stage is a screening stage, in which serious gross errors are eliminated in advance. The GED techniques used in the screening stage are based on multivariate data analysis (MDA), including multivariate data visualization and principal component analysis (PCA). Subtle gross errors are treated at the second stage, in which the serial bias compensation or robust M-estimator is engaged. To achieve a better efficiency in the combined scheme of the least squares based data reconciliation and the GED technique based on hypotheses testing, the Levenberg-Marquardt (LM) algorithm is utilized as the optimizer. To reduce the computation time and stabilize the problem solving for a complex power system such as a combined cycle power plant, meta-modeling using the response surface equation (RSE) and system/process decomposition are incorporated with the simultaneous scheme of SDRMC. The goal of this research work is to reduce the calibration uncertainties and, thus, the risks of providing performance guarantees arisen from uncertainties in performance simulation.

New developments in demographic targeting--the implications of 1991.

PubMed

Humby, C R

1989-01-01

This paper examines benefits that systems such as ACORN, a demographic marketing system that classifies neighborhoods, offer today and monitors some of the trends. It then considers the impact of the 1992 UK census and gives a view of what marketeers can expect in the next 5 years. Neighborhood classifications represent a summary of the consumption patterns of a set of neighbors. If we could reach individuals based on the current life stage the gains to be had would be as great again as that offered by the neighborhood classifications themselves. The greatest weakness of all the neighborhood-based systems is their inability to target at life stage or age.

Portable home hemodialysis for kidney failure.

PubMed

Scott, A

2007-11-01

(1) Home hemodialysis has been in limited use in Canada for some time. Newer, portable hemodialysis machines that are easier for patients to operate may encourage the uptake of this technology. (2) One portable system is already available in the US. The NxStage System One hemodialysis machine operates on standard electric current, does not require plumbing or specialized disinfection, and is small enough for patients to travel with. (3) It is not yet clear whether the use of the NxStage system improves long-term survival and quality of life. (4) Home hemodialysis is less costly than conventional in-centre programs, but it is unknown whether these savings extend to portable devices.

The Peroxide Pathway

NASA Technical Reports Server (NTRS)

McNeal, Curtis I., Jr.; Anderson, William

1999-01-01

NASA's current focus on technology roadmaps as a tool for guiding investment decisions leads naturally to a discussion of NASA's roadmap for peroxide propulsion system development. NASA's new Second Generation Space Transportation System roadmap calls for an integrated Reusable Upper-Stage (RUS) engine technology demonstration in the FY03/FY04 time period. Preceding this integrated demonstration are several years of component developments and subsystem technology demonstrations. NASA and the Air Force took the first steps at developing focused upper stage technologies with the initiation of the Upper Stage Flight Experiment with Orbital Sciences in December 1997. A review of this program's peroxide propulsion development is a useful first step in establishing the peroxide propulsion pathway that could lead to a RUS demonstration in 2004.

Active-passive hybrid piezoelectric actuators for high-precision hard disk drive servo systems

NASA Astrophysics Data System (ADS)

Chan, Kwong Wah; Liao, Wei-Hsin

2006-03-01

Positioning precision is crucial to today's increasingly high-speed, high-capacity, high data density, and miniaturized hard disk drives (HDDs). The demand for higher bandwidth servo systems that can quickly and precisely position the read/write head on a high track density becomes more pressing. Recently, the idea of applying dual-stage actuators to track servo systems has been studied. The push-pull piezoelectric actuated devices have been developed as micro actuators for fine and fast positioning, while the voice coil motor functions as a large but coarse seeking. However, the current dual-stage actuator design uses piezoelectric patches only without passive damping. In this paper, we propose a dual-stage servo system using enhanced active-passive hybrid piezoelectric actuators. The proposed actuators will improve the existing dual-stage actuators for higher precision and shock resistance, due to the incorporation of passive damping in the design. We aim to develop this hybrid servo system not only to increase speed of track seeking but also to improve precision of track following servos in HDDs. New piezoelectrically actuated suspensions with passive damping have been designed and fabricated. In order to evaluate positioning and track following performances for the dual-stage track servo systems, experimental efforts are carried out to implement the synthesized active-passive suspension structure with enhanced piezoelectric actuators using a composite nonlinear feedback controller.

Biased low differential input impedance current receiver/converter device and method for low noise readout from voltage-controlled detectors

DOEpatents

Degtiarenko, Pavel V [Williamsburg, VA; Popov, Vladimir E [Newport News, VA

2011-03-22

A first stage electronic system for receiving charge or current from voltage-controlled sensors or detectors that includes a low input impedance current receiver/converter device (for example, a transimpedance amplifier), which is directly coupled to the sensor output, a source of bias voltage, and the device's power supply (or supplies), which use the biased voltage point as a baseline.

Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging?

PubMed

Wasif, Nabil; Ko, Clifford Y; Farrell, James; Wainberg, Zev; Hines, Oscar J; Reber, Howard; Tomlinson, James S

2010-09-01

AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved prognostication. The Surveillance, Epidemiology, and End Results (SEER) database (1991-2005) was used to identify 8082 patients with resected PAC. The impact of grade on overall and stage-specific survival was assessed using Cox regression analysis. Variables in the model were age, sex, tumor size, lymph node status, and tumor grade. For each AJCC stage, survival was significantly worse for high-grade versus low-grade tumors. On multivariate analysis, high tumor grade was an independent predictor of survival for the entire cohort (hazard ratio [HR] 1.40, 95% confidence interval [95% CI] 1.31-1.48) as well as for stage I (HR 1.28, 95% CI 1.07-1.54), stage IIA (HR 1.43, 95% CI 1.26-1.61), stage IIB (HR 1.38, 95% CI 1.27-1.50), stage III (HR 1.28, 95% CI 1.02-1.59), and stage IV (HR 1.58, 95% CI 1.21-2.05) patients. The addition of grade to staging results in a statistically significant survival discrimination between all stages. Tumor grade is an important prognostic variable of survival in PAC. We propose a novel staging system incorporating grade into current AJCC staging for pancreas cancer. The improved prognostication is more reflective of tumor biology and may impact therapy decisions and stratification of future clinical trials.

Technology Roadmap for Dual-Mode Scramjet Propulsion to Support Space-Access Vision Vehicle Development

NASA Technical Reports Server (NTRS)

Cockrell, Charles E., Jr.; Auslender, Aaron H.; Guy, R. Wayne; McClinton, Charles R.; Welch, Sharon S.

2002-01-01

Third-generation reusable launch vehicle (RLV) systems are envisioned that utilize airbreathing and combined-cycle propulsion to take advantage of potential performance benefits over conventional rocket propulsion and address goals of reducing the cost and enhancing the safety of systems to reach earth orbit. The dual-mode scramjet (DMSJ) forms the core of combined-cycle or combination-cycle propulsion systems for single-stage-to-orbit (SSTO) vehicles and provides most of the orbital ascent energy. These concepts are also relevant to two-stage-to-orbit (TSTO) systems with an airbreathing first or second stage. Foundation technology investments in scramjet propulsion are driven by the goal to develop efficient Mach 3-15 concepts with sufficient performance and operability to meet operational system goals. A brief historical review of NASA scramjet development is presented along with a summary of current technology efforts and a proposed roadmap. The technology addresses hydrogen-fueled combustor development, hypervelocity scramjets, multi-speed flowpath performance and operability, propulsion-airframe integration, and analysis and diagnostic tools.

ADVANCED MANUFACTURING TEAM

NASA Image and Video Library

2014-01-16

ZACK JONES AND JIM LYDON OF MSFC’S ADVANCED MANUFACTURING TEAM, WITH MSFC’S M2 SELECTIVE LASER MELTING SYSTEM. THE M2 IS CURRENTLY DEDICATED TO ADVANCED COPPER MATERIAL DEVELOPMENT FOR THE LOW COST UPPER STAGE PROGRAM.

Technique for Early Reliability Prediction of Software Components Using Behaviour Models

PubMed Central

Ali, Awad; N. A. Jawawi, Dayang; Adham Isa, Mohd; Imran Babar, Muhammad

2016-01-01

Behaviour models are the most commonly used input for predicting the reliability of a software system at the early design stage. A component behaviour model reveals the structure and behaviour of the component during the execution of system-level functionalities. There are various challenges related to component reliability prediction at the early design stage based on behaviour models. For example, most of the current reliability techniques do not provide fine-grained sequential behaviour models of individual components and fail to consider the loop entry and exit points in the reliability computation. Moreover, some of the current techniques do not tackle the problem of operational data unavailability and the lack of analysis results that can be valuable for software architects at the early design stage. This paper proposes a reliability prediction technique that, pragmatically, synthesizes system behaviour in the form of a state machine, given a set of scenarios and corresponding constraints as input. The state machine is utilized as a base for generating the component-relevant operational data. The state machine is also used as a source for identifying the nodes and edges of a component probabilistic dependency graph (CPDG). Based on the CPDG, a stack-based algorithm is used to compute the reliability. The proposed technique is evaluated by a comparison with existing techniques and the application of sensitivity analysis to a robotic wheelchair system as a case study. The results indicate that the proposed technique is more relevant at the early design stage compared to existing works, and can provide a more realistic and meaningful prediction. PMID:27668748

Current state of knowledge of hepatic encephalopathy (part IV): Management of Hepatic Encephalopathy by liver support systems.

PubMed

Hassanein, Tarek

2017-04-01

Hepatic Encephalopathy is a devastating complication of End-Stage Liver Disease. In its severe grades it requires extra intervention beyond the standard medical approaches. In this article were view the role of liver support systems in managing hepatic encephalopthy.

Current Status of Chemical Public Health Risks and Testing Guidelines for Chemical Cardiovascular Safety Assessments

EPA Science Inventory

The cardiovascular system, at all its various developmental and life stages, represents a critical target organ system that can be adversely affected by a variety of chemicals and routes of exposure. A World Health Organization report estimated the impact of environmental chemica...

Adaptive Device Context Based Mobile Learning Systems

ERIC Educational Resources Information Center

Pu, Haitao; Lin, Jinjiao; Song, Yanwei; Liu, Fasheng

2011-01-01

Mobile learning is e-learning delivered through mobile computing devices, which represents the next stage of computer-aided, multi-media based learning. Therefore, mobile learning is transforming the way of traditional education. However, as most current e-learning systems and their contents are not suitable for mobile devices, an approach for…

Design of a High-Energy, Two-Stage Pulsed Plasma Thruster

NASA Technical Reports Server (NTRS)

Markusic, T. E.; Thio, Y. C. F.; Cassibry, J. T.; Rodgers, Stephen L. (Technical Monitor)

2002-01-01

Design details of a proposed high-energy (approx. 50 kJ/pulse), two-stage pulsed plasma thruster are presented. The long-term goal of this project is to develop a high-power (approx. 500 kW), high specific impulse (approx. 7500 s), highly efficient (approx. 50%),and mechanically simple thruster for use as primary propulsion in a high-power nuclear electric propulsion system. The proposed thruster (PRC-PPT1) utilizes a valveless, liquid lithium-fed thermal plasma injector (first stage) followed by a high-energy pulsed electromagnetic accelerator (second stage). A numerical circuit model coupled with one-dimensional current sheet dynamics, as well as a numerical MHD simulation, are used to qualitatively predict the thermal plasma injection and current sheet dynamics, as well as to estimate the projected performance of the thruster. A set of further modelling efforts, and the experimental testing of a prototype thruster, is suggested to determine the feasibility of demonstrating a full scale high-power thruster.

The Structural Heat Intercept-Insulation-Vibration Evaluation Rig (SHIVER)

NASA Technical Reports Server (NTRS)

Johnson, W. L.; Zoeckler, J. G.; Best-Ameen, L. M.

2015-01-01

NASA is currently investigating methods to reduce the boil-off rate on large cryogenic upper stages. Two such methods to reduce the total heat load on existing upper stages are vapor cooling of the cryogenic tank support structure and integration of thick multilayer insulation systems to the upper stage of a launch vehicle. Previous efforts have flown a 2-layer MLI blanket and shown an improved thermal performance, and other efforts have ground-tested blankets up to 70 layers thick on tanks with diameters between 2 3 meters. However, thick multilayer insulation installation and testing in both thermal and structural modes has not been completed on a large scale tank. Similarly, multiple vapor cooled shields are common place on science payload helium dewars; however, minimal effort has gone into intercepting heat on large structural surfaces associated with rocket stages. A majority of the vapor cooling effort focuses on metallic cylinders called skirts, which are the most common structural components for launch vehicles. In order to provide test data for comparison with analytical models, a representative test tank is currently being designed to include skirt structural systems with integral vapor cooling. The tank is 4 m in diameter and 6.8 m tall to contain 5000 kg of liquid hydrogen. A multilayer insulation system will be designed to insulate the tank and structure while being installed in a representative manner that can be extended to tanks up to 10 meters in diameter. In order to prove that the insulation system and vapor cooling attachment methods are structurally sound, acoustic testing will also be performed on the system. The test tank with insulation and vapor cooled shield installed will be tested thermally in the B2 test facility at NASAs Plumbrook Station both before and after being vibration tested at Plumbrooks Space Power Facility.

[Current knowledge on perioperative treatments of non-small cell lung carcinomas].

PubMed

Brosseau, S; Naltet, C; Nguenang, M; Gounant, V; Mordant, P; Milleron, B; Castier, Y; Zalcman, G

2017-06-01

Surgery is still the main treatment in early-stage of non-small cell lung cancer with 5-year survival of stage IA patients exceeding 80%, but 5-year survival of stage II patients rapidly decreasing with tumor size, N status, and visceral pleura invasion. The major metastatic risk in such patients has supported clinical research assessing systemic or loco-regional perioperative treatments. Modern phase 3 trials clearly validated adjuvant or neo-adjuvant platinum-based chemotherapy in resected stage I-III patients as a standard treatment of which value has been reassessed several independent meta-analyses, showing a 5% benefit in 5y-survival, and a decrease of the relative risk for death around from 12 to 25%. Conversely perioperative treatments were not validated for stage IA and IB patients. In more advanced stage patients, neo-adjuvant radio-chemotherapy has not been validated either. Adjuvant radiotherapy for N2 patients is currently tested in the large international phase 3 trial Lung-ART/IFCT-0503. The development of video-assisted thoracic surgery (VATS) has helped adjuvant chemotherapies for elderly patients. Perioperative targeted treatments in NSCLC with EGFR or ALK molecular alterations is currently assessed in the U.S. ALCHEMIST prospective trial. Finally, the role of immune check-points inhibitors is currently evaluated in a large international phase 3 trial testing adjuvant anti-PD-L1 monoclonal antibody, the BR31/IFCT-1401 trial, while a proof-of principle neo-adjuvant trial IONESCO/IFCT-1601, has just begun by the end of the 2016 year, with survival results of both trials expected in 5 to 7 years. Copyright © 2017 SPLF. Published by Elsevier Masson SAS. All rights reserved.

The PLAID graphics analysis impact on the space program

NASA Technical Reports Server (NTRS)

Nguyen, Jennifer P.; Wheaton, Aneice L.; Maida, James C.

1994-01-01

An ongoing project design often requires visual verification at various stages. These requirements are critically important because the subsequent phases of that project might depend on the complete verification of a particular stage. Currently, there are several software packages at JSC that provide such simulation capabilities. We present the simulation capabilities of the PLAID modeling system used in the Flight Crew Support Division for human factors analyses. We summarize some ongoing studies in kinematics, lighting, EVA activities, and discuss various applications in the mission planning of the current Space Shuttle flights and the assembly sequence of the Space Station Freedom with emphasis on the redesign effort.

Power supplies for dual-frequency induction melting of metals

NASA Astrophysics Data System (ADS)

Lusgin, V. I.; Koptyakov, A. S.; Petrov, A. U.; Zinovev, K. A.; Kamaev, D. A.

2018-02-01

The article discusses the benefits of multi frequency induction melting in the production of synthetic cast iron, structural (electric circuit) principles of dual frequency Power supplies of melting systems. The ways of electric power regulation of low frequency and high frequency components of the current in the inductor sections of furnace are demonstrated, namely power rescheduling at the metal melting stage, alloying stage and decarburizing of synthetic cast iron.

A Two-Stage Probabilistic Approach to Manage Personal Worklist in Workflow Management Systems

NASA Astrophysics Data System (ADS)

Han, Rui; Liu, Yingbo; Wen, Lijie; Wang, Jianmin

The application of workflow scheduling in managing individual actor's personal worklist is one area that can bring great improvement to business process. However, current deterministic work cannot adapt to the dynamics and uncertainties in the management of personal worklist. For such an issue, this paper proposes a two-stage probabilistic approach which aims at assisting actors to flexibly manage their personal worklists. To be specific, the approach analyzes every activity instance's continuous probability of satisfying deadline at the first stage. Based on this stochastic analysis result, at the second stage, an innovative scheduling strategy is proposed to minimize the overall deadline violation cost for an actor's personal worklist. Simultaneously, the strategy recommends the actor a feasible worklist of activity instances which meet the required bottom line of successful execution. The effectiveness of our approach is evaluated in a real-world workflow management system and with large scale simulation experiments.

Evaluation of the 8th AJCC staging system for pathologically versus clinically staged pancreatic adenocarcinoma: A time to revisit a dogma?

PubMed

Abdel-Rahman, Omar

2018-02-01

The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic exocrine adenocarcinoma has been released. The current study seeks to assess the 7th and 8th editions among patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been accessed through SEER*Stat program and AJCC 8th edition stages were reconstructed utilizing the collaborative stage descriptions. Kaplan-Meier analysis of overall survival and pancreatic cancer-specific survival analyses (according to both 7th and 8th editions and according to whether pathological or clinical staging were conducted) has been performed. Multivariate analysis of factors affecting pancreatic cancer-specific survival was also conducted through a Cox proportional hazard model. A total of 18  948 patients with pancreatic adenocarcinoma were identified in the period from 2010-2013. Pancreatic cancer-specific survival among pathologically staged patients and according to the 8th edition showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between stage IA and stage IB (P = 0.307) and the comparison between stage IB and stage IIA (P = 0.116). Moreover, P value for stage IA vs IIA was 0.014; while pancreatic cancer-specific survival according to the 7th edition among pathologically staged patients showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between IA and IB (P = 0.072), the comparison between stage IIA and stage IIB (P = 0.065), the comparison between stage IIA and stage III (P = 0.059) and the comparison between IIB and III (P = 0.595). Among clinically staged patients (i.e. those who did not undergo initial radical surgery), the prognostic performance of both 7th and 8th stages for both overall survival and pancreatic cancer-specific survival was limited. There is clearly a need to have two staging systems for pancreatic adenocarcinoma: pathological and clinical staging systems. Copyright © 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

Ion currents involved in oocyte maturation, fertilization and early developmental stages of the ascidian Ciona intestinalis.

PubMed

Tosti, Elisabetta; Gallo, Alessandra; Silvestre, Francesco

2011-01-01

Electrophysiological techniques were used to study the role of ion currents in the ascidian Ciona intestinalis oocyte plasma membrane during different stages of growth, meiosis, fertilization and early development. Three stages of immature oocytes were discriminated in the ovary, with the germinal vesicle showing specific different features of growth and maturation. Stage-A (pre-vitellogenic) oocytes exhibited the highest L-type calcium current activity and were incompetent for meiosis resumption. Stage-B (vitellogenic) oocytes showed a progressive disappearance of calcium currents and the first appearance of sodium currents that remained high during the maturation process, up to the post-vitellogenic stage-C oocytes. The latter had acquired meiotic competence, undergoing spontaneous in vitro maturation and interacting with the spermatozoon. However, fertilized oocytes did not produce normal larvae, suggesting that cytoplasmic maturation may affect embryo development. In mature oocytes at the metaphase I stage, sodium currents were present and remained high up to the zygote stage. Oocytes fertilized in the absence of sodium showed significant reduction of the fertilization current amplitude and high development of anomalous "rosette" embryos. Current amplitudes became negligible in embryos at the 2- and 4-cell stage, whereas resumption of all the current activities occurred at the 8-cell embryo. Taken together, these results suggest: (i) an involvement of L-type calcium currents in initial oocyte meiotic progression and growth; (ii) a role of sodium currents at fertilization; (iii) a role of the fertilization current in ensuring normal embryo development. Copyright © 2011 Wiley Periodicals, Inc.

Development of a hybrid mode linear transformer driver stage

NASA Astrophysics Data System (ADS)

Zhang, Le; Wang, Meng; Zhou, Liangji; Tian, Qing; Guo, Fan; Wang, Lingyun; Qing, Yanling; Zhao, Yue; Dai, Yingmin; Han, Wenhui; Chen, Lin; Xie, Weiping

2018-02-01

At present, the mainstream technologies of primary power sources of large pulse power devices adopt Marx or linear transformer driver (LTD) designs. Based on the analysis of the characteristics of these two types of circuit topologies, the concept of a hybrid mode LTD stage based on Marx branches is proposed. The analysis shows that the hybrid mode LTD stage can realize the following goals: (a) to reduce the energy and power handled by the basic components (switch and capacitor) to lengthen their lifetime; (b) to reduce the requirements of the multipath synchronous trigger system; and (c) to improve the maintainability of the LTD stage by using independent Marx generators instead of "traditional LTD bricks." To verify the technique, a hybrid mode LTD stage consisting of 50 branches (four-stage compact Marx generators) was designed, manufactured and tested. The stage has a radius of about 3.3 m and a height of 0.6 m. The single Marx circuit's load current is about 21 kA, with a rise time of ˜90 ns (10%-90%), under the conditions of capacitors charged to ±40 kV and a 6.9 Ω matched load. The whole stage's load current is ˜1 MA , with a rise time of ˜112 ns (10%-90%), when the capacitors are charged to ±45 kV and the matched load is 0.14 Ω .

Flood-inundation maps for the Tippecanoe River near Delphi, Indiana

USGS Publications Warehouse

Menke, Chad D.; Bunch, Aubrey R.; Kim, Moon H.

2013-01-01

Digital flood-inundation maps for an 11-mile reach of the Tippecanoe River that extends from County Road W725N to State Road 18 below Oakdale Dam, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at USGS streamgage 03333050, Tippecanoe River near Delphi, Ind. Current conditions at the USGS streamgages in Indiana may be obtained online at http://waterdata.usgs.gov/in/nwis/current/?type=flow. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often co-located at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, water-surface profiles were simulated for the stream reach by means of a hydraulic one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relation at USGS streamgage 03333050, Tippecanoe River near Delphi, Ind., and USGS streamgage 03332605, Tippecanoe River below Oakdale Dam, Ind. The hydraulic model was then used to simulate 13 water-surface profiles for flood stages at 1-foot intervals reference to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. A flood inundation map was generated for each water-surface profile stage (13 maps in all) so that, for any given flood stage, users will be able to view the estimated area of inundation. The availability of these maps, along with current stage from USGS streamgages and forecasted stream stages from the NWS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Flood-inundation maps for the Yellow River at Plymouth, Indiana

USGS Publications Warehouse

Menke, Chad D.; Bunch, Aubrey R.; Kim, Moon H.

2016-11-16

Digital flood-inundation maps for a 4.9-mile reach of the Yellow River at Plymouth, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 05516500, Yellow River at Plymouth, Ind. Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/in/nwis/uv?site_no=05516500. In addition, information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood-warning system (http:/water.weather.gov/ahps/). The NWS AHPS forecasts flood hydrographs at many sites that are often collocated with USGS streamgages, including the Yellow River at Plymouth, Ind. NWS AHPS-forecast peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood and forecasts of flood hydrographs at this site.For this study, flood profiles were computed for the Yellow River reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the current stage-discharge relations at the Yellow River streamgage, in combination with the flood-insurance study for Marshall County (issued in 2011). The calibrated hydraulic model was then used to determine eight water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The 1-percent annual exceedance probability flood profile elevation (flood elevation with recurrence intervals within 100 years) is within the calibrated water-surface elevations for comparison. The simulated water-surface profiles were then used with a geographic information system (GIS) digital elevation model (DEM, derived from Light Detection and Ranging [lidar]) in order to delineate the area flooded at each water level.The availability of these maps, along with Internet information regarding current stage from the USGS streamgage 05516500, Yellow River at Plymouth, Ind., and forecast stream stages from the NWS AHPS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for postflood recovery efforts.

ADVANCED MANUFACTURING TEAM

NASA Image and Video Library

2014-01-16

QUINCY BEAN, JIM LYDON, AND ZACK JONES OF MSFC’S ADVANCED MANUFACTURING TEAM, WITH MSFC’S M2 SELECTIVE LASER MELTING SYSTEM. THE M2 IS CURRENTLY DEDICATED TO ADVANCED COPPER MATERIAL DEVELOPMENT FOR THE LOW COST UPPER STAGE PROGRAM.

Biomass waste gasification - can be the two stage process suitable for tar reduction and power generation?

PubMed

Sulc, Jindřich; Stojdl, Jiří; Richter, Miroslav; Popelka, Jan; Svoboda, Karel; Smetana, Jiří; Vacek, Jiří; Skoblja, Siarhei; Buryan, Petr

2012-04-01

A pilot scale gasification unit with novel co-current, updraft arrangement in the first stage and counter-current downdraft in the second stage was developed and exploited for studying effects of two stage gasification in comparison with one stage gasification of biomass (wood pellets) on fuel gas composition and attainable gas purity. Significant producer gas parameters (gas composition, heating value, content of tar compounds, content of inorganic gas impurities) were compared for the two stage and the one stage method of the gasification arrangement with only the upward moving bed (co-current updraft). The main novel features of the gasifier conception include grate-less reactor, upward moving bed of biomass particles (e.g. pellets) by means of a screw elevator with changeable rotational speed and gradual expanding diameter of the cylindrical reactor in the part above the upper end of the screw. The gasifier concept and arrangement are considered convenient for thermal power range 100-350 kW(th). The second stage of the gasifier served mainly for tar compounds destruction/reforming by increased temperature (around 950°C) and for gasification reaction of the fuel gas with char. The second stage used additional combustion of the fuel gas by preheated secondary air for attaining higher temperature and faster gasification of the remaining char from the first stage. The measurements of gas composition and tar compound contents confirmed superiority of the two stage gasification system, drastic decrease of aromatic compounds with two and higher number of benzene rings by 1-2 orders. On the other hand the two stage gasification (with overall ER=0.71) led to substantial reduction of gas heating value (LHV=3.15 MJ/Nm(3)), elevation of gas volume and increase of nitrogen content in fuel gas. The increased temperature (>950°C) at the entrance to the char bed caused also substantial decrease of ammonia content in fuel gas. The char with higher content of ash leaving the second stage presented only few mass% of the inlet biomass stream. Copyright © 2011 Elsevier Ltd. All rights reserved.

Current management of hepatocellular carcinoma

PubMed Central

Tabrizian, Parissa; Roayaie, Sasan; Schwartz, Myron E

2014-01-01

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and leading cause of death among patients with cirrhosis. Treatment guidelines are based according to the Barcelona Clinic Liver Cancer staging system. The choice among therapeutic options that include liver resection, liver transplantation, locoregional, and systemic treatments must be individualized for each patient. The aim of this paper is to review the outcomes that can be achieved in the treatment of HCC with the heterogeneous therapeutic options currently available in clinical practice. PMID:25132740

A Power Conditioning Stage Based on Analog-Circuit MPPT Control and a Superbuck Converter for Thermoelectric Generators in Spacecraft Power Systems

NASA Astrophysics Data System (ADS)

Sun, Kai; Wu, Hongfei; Cai, Yan; Xing, Yan

2014-06-01

A thermoelectric generator (TEG) is a very important kind of power supply for spacecraft, especially for deep-space missions, due to its long lifetime and high reliability. To develop a practical TEG power supply for spacecraft, a power conditioning stage is indispensable, being employed to convert the varying output voltage of the TEG modules to a definite voltage for feeding batteries or loads. To enhance the system reliability, a power conditioning stage based on analog-circuit maximum-power-point tracking (MPPT) control and a superbuck converter is proposed in this paper. The input of this power conditioning stage is connected to the output of the TEG modules, and the output of this stage is connected to the battery and loads. The superbuck converter is employed as the main circuit, featuring low input current ripples and high conversion efficiency. Since for spacecraft power systems reliable operation is the key target for control circuits, a reset-set flip-flop-based analog circuit is used as the basic control circuit to implement MPPT, being much simpler than digital control circuits and offering higher reliability. Experiments have verified the feasibility and effectiveness of the proposed power conditioning stage. The results show the advantages of the proposed stage, such as maximum utilization of TEG power, small input ripples, and good stability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oberije, Cary, E-mail: cary.oberije@maastro.nl; De Ruysscher, Dirk; Universitaire Ziekenhuizen Leuven, KU Leuven

Purpose: Although patients with stage III non-small cell lung cancer (NSCLC) are homogeneous according to the TNM staging system, they form a heterogeneous group, which is reflected in the survival outcome. The increasing amount of information for an individual patient and the growing number of treatment options facilitate personalized treatment, but they also complicate treatment decision making. Decision support systems (DSS), which provide individualized prognostic information, can overcome this but are currently lacking. A DSS for stage III NSCLC requires the development and integration of multiple models. The current study takes the first step in this process by developing andmore » validating a model that can provide physicians with a survival probability for an individual NSCLC patient. Methods and Materials: Data from 548 patients with stage III NSCLC were available to enable the development of a prediction model, using stratified Cox regression. Variables were selected by using a bootstrap procedure. Performance of the model was expressed as the c statistic, assessed internally and on 2 external data sets (n=174 and n=130). Results: The final multivariate model, stratified for treatment, consisted of age, gender, World Health Organization performance status, overall treatment time, equivalent radiation dose, number of positive lymph node stations, and gross tumor volume. The bootstrapped c statistic was 0.62. The model could identify risk groups in external data sets. Nomograms were constructed to predict an individual patient's survival probability ( (www.predictcancer.org)). The data set can be downloaded at (https://www.cancerdata.org/10.1016/j.ijrobp.2015.02.048). Conclusions: The prediction model for overall survival of patients with stage III NSCLC highlights the importance of combining patient, clinical, and treatment variables. Nomograms were developed and validated. This tool could be used as a first building block for a decision support system.« less

A noninterference blade vibration measurement system for gas turbine engines

NASA Astrophysics Data System (ADS)

Watkins, William B.; Chi, Ray M.

1987-06-01

A noninterfering blade vibration system has been demonstrated in tests of a gas turbine first stage fan. Conceptual design of the system, including its theory, design of case mounted probes, and data acquisition and signal processing hardware was done in a previous effort. The current effort involved instrumentation of an engine fan stage with strain gages; data acquisition using shaft-mounted reference and case-mounted optical probes; recording of data on a wideband tape recorder; and posttest processing using off-line analysis in a facility computer and a minicomputer-based readout system designed for near- real-time readout. Results are presented in terms of true blade vibration frequencies, time and frequency dependent vibration amplitudes and comparison of the optical noninterference results with strain gage readings.

Biomass waste gasification - Can be the two stage process suitable for tar reduction and power generation?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sulc, Jindrich; Stojdl, Jiri; Richter, Miroslav

2012-04-15

Highlights: Black-Right-Pointing-Pointer Comparison of one stage (co-current) and two stage gasification of wood pellets. Black-Right-Pointing-Pointer Original arrangement with grate-less reactor and upward moving bed of the pellets. Black-Right-Pointing-Pointer Two stage gasification leads to drastic reduction of tar content in gas. Black-Right-Pointing-Pointer One stage gasification produces gas with higher LHV at lower overall ER. Black-Right-Pointing-Pointer Content of ammonia in gas is lower in two stage moving bed gasification. - Abstract: A pilot scale gasification unit with novel co-current, updraft arrangement in the first stage and counter-current downdraft in the second stage was developed and exploited for studying effects of two stagemore » gasification in comparison with one stage gasification of biomass (wood pellets) on fuel gas composition and attainable gas purity. Significant producer gas parameters (gas composition, heating value, content of tar compounds, content of inorganic gas impurities) were compared for the two stage and the one stage method of the gasification arrangement with only the upward moving bed (co-current updraft). The main novel features of the gasifier conception include grate-less reactor, upward moving bed of biomass particles (e.g. pellets) by means of a screw elevator with changeable rotational speed and gradual expanding diameter of the cylindrical reactor in the part above the upper end of the screw. The gasifier concept and arrangement are considered convenient for thermal power range 100-350 kW{sub th}. The second stage of the gasifier served mainly for tar compounds destruction/reforming by increased temperature (around 950 Degree-Sign C) and for gasification reaction of the fuel gas with char. The second stage used additional combustion of the fuel gas by preheated secondary air for attaining higher temperature and faster gasification of the remaining char from the first stage. The measurements of gas composition and tar compound contents confirmed superiority of the two stage gasification system, drastic decrease of aromatic compounds with two and higher number of benzene rings by 1-2 orders. On the other hand the two stage gasification (with overall ER = 0.71) led to substantial reduction of gas heating value (LHV = 3.15 MJ/Nm{sup 3}), elevation of gas volume and increase of nitrogen content in fuel gas. The increased temperature (>950 Degree-Sign C) at the entrance to the char bed caused also substantial decrease of ammonia content in fuel gas. The char with higher content of ash leaving the second stage presented only few mass% of the inlet biomass stream.« less

A novel two-stage evaluation system based on a Group-G1 approach to identify appropriate emergency treatment technology schemes in sudden water source pollution accidents.

PubMed

Qu, Jianhua; Meng, Xianlin; Hu, Qi; You, Hong

2016-02-01

Sudden water source pollution resulting from hazardous materials has gradually become a major threat to the safety of the urban water supply. Over the past years, various treatment techniques have been proposed for the removal of the pollutants to minimize the threat of such pollutions. Given the diversity of techniques available, the current challenge is how to scientifically select the most desirable alternative for different threat degrees. Therefore, a novel two-stage evaluation system was developed based on a circulation-correction improved Group-G1 method to determine the optimal emergency treatment technology scheme, considering the areas of contaminant elimination in both drinking water sources and water treatment plants. In stage 1, the threat degree caused by the pollution was predicted using a threat evaluation index system and was subdivided into four levels. Then, a technique evaluation index system containing four sets of criteria weights was constructed in stage 2 to obtain the optimum treatment schemes corresponding to the different threat levels. The applicability of the established evaluation system was tested by a practical cadmium-contaminated accident that occurred in 2012. The results show this system capable of facilitating scientific analysis in the evaluation and selection of emergency treatment technologies for drinking water source security.

An advanced telerobotic system for shuttle payload changeout room processing applications

NASA Technical Reports Server (NTRS)

Sklar, M.; Wegerif, D.

1989-01-01

To potentially alleviate the inherent difficulties in the ground processing of the Space Shuttle and its associated payloads, a teleoperated, semi-autonomous robotic processing system for the Payload Changeout Room (PCR) is now in the conceptual stages. The complete PCR robotic system as currently conceived is described and critical design issues and the required technologies are discussed.

SAFIS Area Estimation Techniques

Treesearch

Gregory A. Reams

2000-01-01

The Southern Annual Forest inventory System (SAFIS) is in various stages of implementation in 8 of the 13 southern states served by the Southern Research Station of the USDA Forest Service. Compared to periodic inventories, SAFIS requires more rapid generation of land use and land cover maps. The current photo system for phase one area estimation has changed little...

SAFIS area estimation techniques

Treesearch

Gregory A. Reams

2000-01-01

The Southern Annual Forest Inventory System (SAFIS) is in various stages of implementation in 8 of the 13 southern states served by the Southern Research Station of the USDA Forest Service. Compared to periodic inventories, SAFIS requires more rapid generation of land use and land cover maps. The current photo system for phase one area estimation has changed little...

Advances in Lymphatic Imaging and Drug Delivery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nune, Satish K.; Gunda, Padmaja; Majeti, Bharat K.

2011-09-10

Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastlymore » improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.« less

An university-scale pulsed-power system using a bipolar Marx generator

NASA Astrophysics Data System (ADS)

Chang, Po-Yu; Yang, Sheng-Hua; Huang, Mei-Feng; Isaps, Natl Cheng Kung Univ Team

2017-10-01

A bipolar Marx generator is being built for x-ray sources or laboratory astrophysics and space research for university-scale laboratory. The system consists of ten stages. In each stage, two 1 μF capacitors connected in series are charged to +/- 30 kV storing 9 kJ of total energy. It delivers a current of 200 kA to the load with a 200 ns rise time during the discharge. It will be used for following three purposes: (1) gas-puff z pinches generating soft x-ray for bio-medical research in the future; (2) generating plasma jets to study interactions between plasma flows and unmagnetized/magnetized obstacles analogous to the interactions between solar winds and planetary magnetic fields or unmagnetized planets; and (3) studying the pinch in a dense plasma focus device. The results of current measurements and circuit characteristics are shown.

Relation between premorbid personality and patterns of emotion expression in mid- to late-stage dementia.

PubMed

Magai, C; Cohen, C I; Culver, C; Gomberg, D; Malatesta, C

1997-11-01

Twenty-seven nursing home patients with mid- to late-stage dementia participated in a study of the relation between preillness personality, as indexed by attachment and emotion regulation style, and current emotional behavior. Preillness measures were completed by family members and current assessments of emotion were supplied by nursing home aides and family members; in addition, emotion was coded during a family visit using an objective coding system for facial emotion expressions. Attachment style was found to be related to the expression of positive affect, with securely attached individuals displaying more positive affect than avoidantly attached individuals. In addition, high ratings on premorbid hostility were associated with higher rates of negative affect and lower rates of positive affect. These findings indicate that premorbid aspects of personality show continuity over time, even in mid- to late-stage dementia.

The pressing need for real-time risk assessment of hospital-acquired acute kidney injury.

PubMed

Warnock, David G

2017-05-01

Acute Kidney Injury (AKI) is associated with short- and long-term outcomes that reflect the severity of the injury. Recent studies have suggested that 'early' initiation of renal replacement therapy may alter the course of AKI and improve short-term outcomes like inpatient mortality. The current Kidney Disease Improving Global Outcomes (KDIGO) consensus definition of AKI has been criticized for misclassification bias, lack of sensitivity and the static manner in which AKI stages are defined. This editorial reviews various approaches to improving the specificity and sensitivity of the KDIGO AKI criteria, and also concludes that a staging system based on creatinine trajectories would be better suited for developing a prognostic index for real-time, dynamic risk assessment that the current KDIGO staging criteria. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

[Obesity associated risk using Edmonton staging in bariatric surgery].

PubMed

de Cos, Ana Isabel; Cardenas, Jersy J; Pelegrina, Beatriz; Roldan, M Concepción; Calvo, Isabel; Vázquez, Clotilde; Pallardo, Luis Felipe

2014-09-20

With a prevalence of Morbid Obesity of 1,2% of the Spanish population, the current criteria for Bariatric Surgery do not classify patients taking into consideration co-morbidities or functional status. We need new staging systems useful in predicting mortality and able to support prioritizing treatments. Applying Edmonton staging system to patients awaiting Bariatric Surgery. Data collected from 81 patients from 2011- 2013 after pre-surgery protocol. Weight, height, waist, BMI, biochemical parameters and blood pressure are registered. Also taken down are hepatic, renal, osteoarticular diseases, sleep-apnea syndrome and/or gastro-oesophageal reflux, if present. Edmonton staging of ten variables is applied to each patient. 81 patients: 67% women, average age 47y, 18% below 30y. Average BMI of 47, 90% of patients have a BMI >40. 34% of patients show sleep-apnea syndrome and 25% gastro-oesophageal reflux. 9% of the patients have a BMI >45, diabetes mellitus and sleep-apnea syndrome. Applying the Edmonton Staging, nine patients (11%) are in the highest risk range (stage 3), 70% are in the high-risk range (stage 2) and 15 patients (18%) are included in the low-risk range. No patient was found to be in stage 0 without obesity risk factors. The Edmonton staging system provides us with information on presence or extent of co-morbidities that guide decision making in individuals. The mortality- predictive ability of Edmonton proposal could help to assist in determining the urgency of Bariatric Surgery and establish better criteria to prioritize these group of patients. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

A Validated Prediction Model for Overall Survival From Stage III Non-Small Cell Lung Cancer: Toward Survival Prediction for Individual Patients.

PubMed

Oberije, Cary; De Ruysscher, Dirk; Houben, Ruud; van de Heuvel, Michel; Uyterlinde, Wilma; Deasy, Joseph O; Belderbos, Jose; Dingemans, Anne-Marie C; Rimner, Andreas; Din, Shaun; Lambin, Philippe

2015-07-15

Although patients with stage III non-small cell lung cancer (NSCLC) are homogeneous according to the TNM staging system, they form a heterogeneous group, which is reflected in the survival outcome. The increasing amount of information for an individual patient and the growing number of treatment options facilitate personalized treatment, but they also complicate treatment decision making. Decision support systems (DSS), which provide individualized prognostic information, can overcome this but are currently lacking. A DSS for stage III NSCLC requires the development and integration of multiple models. The current study takes the first step in this process by developing and validating a model that can provide physicians with a survival probability for an individual NSCLC patient. Data from 548 patients with stage III NSCLC were available to enable the development of a prediction model, using stratified Cox regression. Variables were selected by using a bootstrap procedure. Performance of the model was expressed as the c statistic, assessed internally and on 2 external data sets (n=174 and n=130). The final multivariate model, stratified for treatment, consisted of age, gender, World Health Organization performance status, overall treatment time, equivalent radiation dose, number of positive lymph node stations, and gross tumor volume. The bootstrapped c statistic was 0.62. The model could identify risk groups in external data sets. Nomograms were constructed to predict an individual patient's survival probability (www.predictcancer.org). The data set can be downloaded at https://www.cancerdata.org/10.1016/j.ijrobp.2015.02.048. The prediction model for overall survival of patients with stage III NSCLC highlights the importance of combining patient, clinical, and treatment variables. Nomograms were developed and validated. This tool could be used as a first building block for a decision support system. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Some Aspects of an Air-Core Single-Coil Magnetic Suspension System

NASA Technical Reports Server (NTRS)

Hamlet, Irvin L.; Kilgore, Robert A.

1966-01-01

This paper presents some of the technical aspects in the development at the Langley Research Center of an air-cove, dual-wound, single-coil, magnetic-suspension system with one-dimensional control. Overall electrical system design features and techniques are discussed in addition to the problems of control and stability. Special treatment is given to the operation of a dual-wound, high-current support coil which provides the bias fields and superimposed modulated field. Other designs features include a six-phase, solid-state power stage for modulation of the relatively large magnitude control current, and an associated six-phase trigger circuit.

Clinical information transfer and data capture in the acute myocardial infarction pathway: an observational study.

PubMed

Kesavan, Sujatha; Kelay, Tanika; Collins, Ruth E; Cox, Benita; Bello, Fernando; Kneebone, Roger L; Sevdalis, Nick

2013-10-01

Acute myocardial infarctions (MIs) or heart attacks are the result of a complete or an incomplete occlusion of the lumen of the coronary artery with a thrombus. Prompt diagnosis and early coronary intervention results in maximum myocardial salvage, hence time to treat is of the essence. Adequate, accurate and complete information is vital during the early stages of admission of an MI patient and can impact significantly on the quality and safety of patient care. This study aimed to record how clinical information between different clinical teams during the journey of a patient in the MI care pathway is captured and to review the flow of information within this care pathway. A prospective, descriptive, structured observational study to assess (i) current clinical information systems (CIS) utilization and (ii) real-time information availability within an acute cardiac care setting was carried out. Completeness and availability of patient information capture across four key stages of the MI care pathway were assessed prospectively. Thirteen separate information systems were utilized during the four phases of the MI pathway. Observations revealed fragmented CIS utilization, with users accessing an average of six systems to gain a complete set of patient information. Data capture was found to vary between each pathway stage and in both patient cohort risk groupings. The highest level of information completeness (100%) was observed only in the discharge stage of the MI care pathway. The lowest level of information completeness (58%) was observed in the admission stage. The study highlights fragmentation, CIS duplication, and discrepancies in the current clinical information capture and data transfer across the MI care pathway in an acute cardiac care setting. The development of an integrated and user-friendly electronic data capture and transfer system would reduce duplication and would facilitate efficient and complete information provision at the point of care. © 2012 John Wiley & Sons Ltd.

Commercial mode-locked vertical external cavity surface emitting lasers

NASA Astrophysics Data System (ADS)

Head, C. Robin; Paboeuf, David; Ortega, Tiago; Lubeigt, Walter; Bialkowski, Bartlomiej; Lin, Jipeng; Hempler, Nils; Maker, Gareth T.; Malcolm, Graeme P. A.

2018-02-01

This paper presents the latest efforts in the development of commercial optically-pumped semiconductor disk lasers (SDLs) at M Squared Lasers. Two types of SDLs are currently being developed: an ultrafast system and a continuous wave single frequency system under the names of Dragonfly and Infinite, respectively. Both offer a compact, low-cost, easy-to-use and maintenance-free tool for a range of growing markets including nonlinear microscopy and quantum technology. To facilitate consumer uptake of the SDL technology, the performance specifications aim to closely match the currently employed systems. An extended Dragonfly system is being developed targeting the nonlinear microscopy market, which typically requires 1-W average power pulse trains with pulse durations below 200 fs. The pulse repetition frequency (PRF) of the commonly used laser systems, typically Titanium-sapphire lasers, is 80 MHz. This property is particularly challenging for mode-locked SDLs which tend to operate at GHz repetition rates, due to their short upper state carrier lifetime. Dragonfly has found a compromise at 200 MHz to balance mode-locking instabilities with a low PRF. In the ongoing development of Dragonfly, additional pulse compression and nonlinear spectral broadening stages are used to obtain pulse durations as short as 130 fs with an average power of 0.85 W, approaching the required performance. A variant of the Infinite system was adapted to provide a laser source suitable for the first stage of Sr atom cooling at 461 nm. Such a source requires average powers of approximately 1 W with a sub-MHz linewidth. As direct emission in the blue is not a viable approach at this stage, an SDL emitting at 922 nm followed by an M Squared Lasers SolTiS ECD-X doubler is currently under development. The SDL oscillator delivered >1 W of single frequency (RMS frequency noise <150kHz) light at 922 nm.

A two-step automatic sleep stage classification method with dubious range detection.

PubMed

Sousa, Teresa; Cruz, Aniana; Khalighi, Sirvan; Pires, Gabriel; Nunes, Urbano

2015-04-01

The limitations of the current systems of automatic sleep stage classification (ASSC) are essentially related to the similarities between epochs from different sleep stages and the subjects' variability. Several studies have already identified the situations with the highest likelihood of misclassification in sleep scoring. Here, we took advantage of such information to develop an ASSC system based on knowledge of subjects' variability of some indicators that characterize sleep stages and on the American Academy of Sleep Medicine (AASM) rules. An ASSC system consisting of a two-step classifier is proposed. In the first step, epochs are classified using support vector machines (SVMs) spread into different nodes of a decision tree. In the post-processing step, the epochs suspected of misclassification (dubious classification) are tagged, and a new classification is suggested. Identification and correction are based on the AASM rules, and on misclassifications most commonly found/reported in automatic sleep staging. Six electroencephalographic and two electrooculographic channels were used to classify wake, non-rapid eye movement (NREM) sleep--N1, N2 and N3, and rapid eye movement (REM) sleep. The proposed system was tested in a dataset of 14 clinical polysomnographic records of subjects suspected of apnea disorders. Wake and REM epochs not falling in the dubious range, are classified with accuracy levels compatible with the requirements for clinical applications. The suggested correction assigned to the epochs that are tagged as dubious enhances the global results of all sleep stages. This approach provides reliable sleep staging results for non-dubious epochs. Copyright © 2015 Elsevier Ltd. All rights reserved.

Progress on Ares First Stage Propulsion

NASA Technical Reports Server (NTRS)

Priskos, Alex S.; Tiller, Bruce

2008-01-01

The mission of the National Aeronautics and Space Administration (NASA) is not simply to maintain its current position with the International Space Station and other space exploration endeavors, but to build a permanent outpost on the Moon and then travel on to explore ever more distant terrains. The Constellation Program will oversee the development of the crew capsule, launch vehicles, and other systems needed to achieve this mission. From this initiative will come two new launch vehicles: the Ares I and Ares V. The Ares I will be a human-rated vehicle, which will be used for crew transport; the Ares V, a cargo transport vehicle, will be the largest launch vehicle ever built. The Ares Projects team at Marshall Space Flight Center (MSFC) in Huntsville, Alabama is assigned with developing these two new vehicles. The Ares I vehicle will have an in-line, two-stage rocket configuration. The first stage will provide the thrust or propulsion component for the Ares rocket systems through the first two minutes of the mission. The First Stage Team is tasked with developing the propulsion system necessary to liftoff from the Earth and loft the entire Ares vehicle stack toward low-Earth orbit. Building on the legacy of the Space Shuttle and other NASA space exploration initiatives, the propulsion for the Ares I First Stage will be a Shuttle-derived reusable solid rocket motor. Progress to date by the First Stage Team has been robust and on schedule. This paper provides an update on the design and development of the Ares First Stage Propulsion system.

Investigating the development of double-peak subauroral ion drift (DSAID)

NASA Astrophysics Data System (ADS)

Horvath, Ildiko; Lovell, Brian C.

2017-04-01

This study focuses on the newly described ionospheric feature, called double-peak subauroral ion drift (DSAID), which is a subclass of the well-known single-peak SAID. Double-layer Region 2 (R2) field aligned currents (FACs) could be the main driver of DSAID. Our aim is to gain new insights into the development of DSAID during its two-stage progression. Observational results are provided by five scenarios, each demonstrating a certain progression sequence of DSAID. Results show that SAID/DSAID occurred during flux transfer events and was accompanied by flow channels (FCs) associated with dayside magnetopause (FC-2) and nightside magnetotail (FC-3) reconnections, with westward electrojet (eastward FC), and with auroral streamers (FC-4). In the premidnight magnetic local time (MLT) sector of stage 2, DSAID development was due to the short-circuiting of the reconnection-injected plasma jets during substorms or pseudobreakups. Thus, the related ring current pressure buildup enhanced the downward R2 FACs leading to double/multiple circuits forming double-layer R2 FACs. During the midnight MLT hours of stage 2, DSAID development was closely related to the westward traveling surge (WTS)/substorm current wedge (SCW). WTS/SCW-related strong upward R1 FACs closed with meriodional currents producing eastward and downward (i.e., downward R2 FAC-style) return currents enhancing the downward R2 FACs and thus leading to double/multiple circuits forming double-layer R2 FACs. Auroral streamers/FC-4 represent a substorm substructure and their occurrence with DSAID after stage 2 demonstrates that this substructure occasionally includes DSAID. Our results demonstrate also that the short-circuited system underlying SAID/DSAID acted sometimes as a current generator and sometimes as a voltage generator.

Demonstration of a switchable damping system to allow low-noise operation of high-Q low-mass suspension systems

NASA Astrophysics Data System (ADS)

Hennig, Jan-Simon; Barr, Bryan W.; Bell, Angus S.; Cunningham, William; Danilishin, Stefan L.; Dupej, Peter; Gräf, Christian; Hough, James; Huttner, Sabina H.; Jones, Russell; Leavey, Sean S.; Pascucci, Daniela; Sinclair, Martin; Sorazu, Borja; Spencer, Andrew; Steinlechner, Sebastian; Strain, Kenneth A.; Wright, Jennifer; Zhang, Teng; Hild, Stefan

2017-12-01

Low-mass suspension systems with high-Q pendulum stages are used to enable quantum radiation pressure noise limited experiments. Utilizing multiple pendulum stages with vertical blade springs and materials with high-quality factors provides attenuation of seismic and thermal noise; however, damping of these high-Q pendulum systems in multiple degrees of freedom is essential for practical implementation. Viscous damping such as eddy-current damping can be employed, but it introduces displacement noise from force noise due to thermal fluctuations in the damping system. In this paper we demonstrate a passive damping system with adjustable damping strength as a solution for this problem that can be used for low-mass suspension systems without adding additional displacement noise in science mode. We show a reduction of the damping factor by a factor of 8 on a test suspension and provide a general optimization for this system.

Flood-inundation maps for the Wabash River at Memorial Bridge at Vincennes, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.; Menke, Chad D.

2017-08-23

Digital flood-inundation maps for a 10.2-mile reach of the Wabash River from Sevenmile Island to 3.7 mile downstream of Memorial Bridge (officially known as Lincoln Memorial Bridge) at Vincennes, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at USGS streamgage 03343010, Wabash River at Memorial Bridge at Vincennes, Ind. Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at this site.For this study, flood profiles were computed for the Wabash River reach by means of a one-dimensional stepbackwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at USGS streamgage 03343010, Wabash River at Memorial Bridge at Vincennes, Ind., and preliminary high-water marks from a high-water event on April 27, 2013. The calibrated hydraulic model was then used to determine 19 water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from 10 feet (ft) or near bankfull to 28 ft, the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a Geographic Information System (GIS) digital elevation model (DEM, derived from Light Detection and Ranging [lidar] data having a 0.98-ft vertical accuracy and 4.9-ft horizontal resolution) in order to delineate the area flooded at each water level.The availability of these maps—along with Internet information regarding current stage from the USGS streamgage 03343010, and forecast stream stages from the NWS AHPS—provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project.

PubMed

Sano, Takeshi; Coit, Daniel G; Kim, Hyung Ho; Roviello, Franco; Kassab, Paulo; Wittekind, Christian; Yamamoto, Yuko; Ohashi, Yasuo

2017-03-01

The current AJCC staging system for gastric cancer (AJCC7) incorporated several major revisions to the previous edition. The T and N categories and the stage groups were newly defined, and adenocarcinoma of the esophagogastric junction (EGJ) was reclassified and staged according to the esophageal system. Studies to validate these changes showed inconsistent results. The International Gastric Cancer Association (IGCA) launched a project to support evidence-based revisions to the next edition of the AJCC staging system. Clinical and pathological data on patients who underwent curative gastrectomy at 59 institutions in 15 countries between 2000 and 2004 were retrospectively collected. Patients lost to follow-up within 5 years of surgery were excluded. Patients treated with neoadjuvant therapy were excluded. The data were analyzed in total, and separately by region of treatment. Of 25,411 eligible cases, 84.8 % were submitted from 24 institutions of Japan and Korea, 6.4 % from other Asian countries, and 8.8 % from 29 Western institutions. The T and N categories of AJCC7 clearly stratified the patient survival. Patients with pN3a and pN3b showed distinct prognosis in all regions, and by introducing pN3a and pN3b into a cluster analysis, we established a new stage grouping with better stratification than AJCC7, especially among stage III subgroups. Survival of Siewert type 2 and 3 EGJ tumors was better stratified by this IGCA stage grouping than by either esophageal or gastric scheme of AJCC7. For the next revision of AJCC classification, we propose a new stage grouping based on a large, worldwide data collection.

Flood-inundation maps for the Wabash River at Terre Haute, Indiana

USGS Publications Warehouse

Lombard, Pamela J.

2013-01-01

Digital flood-inundation maps for a 6.3-mi reach of the Wabash River from 0.1 mi downstream of the Interstate 70 bridge to 1.1 miles upstream of the Route 63 bridge, Terre Haute, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent of flooding corresponding to select water levels (stages) at the USGS streamgage Wabash River at Terre Haute (station number 03341500). Current conditions at the USGS streamgage may be obtained on the Internet from the USGS National Water Information System (http://waterdata.usgs.gov/in/nwis/uv/?site_no=03341500&agency_cd=USGS&p"). In addition, the same data are provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps//). Within this system, the NWS forecasts flood hydrographs for the Wabash River at Terre Haute that may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relation at the Wabash River at the Terre Haute streamgage. The hydraulic model was then used to compute 22 water-surface profiles for flood stages at 1-ft interval referenced to the streamgage datum and ranging from bank-full to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data having a 0.37-ft vertical accuracy and a 1.02-ft horizontal accuracy) to delineate the area flooded at each water level. The availability of these maps along with Internet information regarding the current stage from the USGS streamgage and forecasted stream stages from the NWS can provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post flood recovery efforts.

Flood-inundation maps for the Iroquois River at Rensselaer, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.; Bunch, Aubrey R.

2013-01-01

Digital flood-inundation maps for a 4.0-mile reach of the Iroquois River at Rensselaer, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at USGS streamgage 05522500, Iroquois River at Rensselaer, Ind. Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at (http://waterdata.usgs.gov/in/nwis/uv?site_no=05522500). In addition, the National Weather Service (NWS) forecasts flood hydrographs at the Rensselaer streamgage. That forecasted peak-stage information, also available on the Internet (http://water.weather.gov/ahps/), may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. For this study, flood profiles were computed for the Iroquois River reach by means of a one-dimensional step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the most current (June 27, 2012) stage-discharge relations at USGS streamgage 05522500, Iroquois River at Rensselaer, Ind., and high-water marks from the flood of July 2003. The calibrated hydraulic model was then used to determine nine water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from bankfull to the highest stage of the current stage-discharge rating curve. The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage at Rensselaer, Ind., and forecasted stream stages from the NWS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Costing for the Future: Exploring Cost Estimation With Unmanned Autonomous Systems

DTIC Science & Technology

2016-04-30

account for how cost estimating for autonomy is different than current methodologies and to suggest ways it can be addressed through the integration and...The Development stage involves refining the system requirements, creating a solution description , and building a system. 3. The Operational Test...parameter describes the extent to which efficient fabrication methodologies and processes are used, and the automation of labor-intensive operations

Flood-tracking chart for the Withlacoochee and Little River Basins in south-central Georgia and northern Florida

USGS Publications Warehouse

Gotvald, Anthony J.; McCallum, Brian E.; Painter, Jaime A.

2014-01-01

The U.S. Geological Survey (USGS), in cooperation with other Federal, State, and local agencies, operates a flood-monitoring system in the Withlacoochee and Little River Basins. This system is a network of automated river stage stations (ten are shown on page 2 of this publication) that transmit stage data through satellite telemetry to the USGS in Atlanta, Georgia and the National Weather Service (NWS) in Peachtree City, Georgia. During floods, the public and emergency response agencies use this information to make decisions about road closures, evacuations, and other public safety issues. This Withlacoochee and Little River Basins flood-tracking chart can be used by local citizens and emergency response personnel to record the latest river stage and predicted flood-crest information along the Withlacoochee River, Little River, and Okapilco Creek in south-central Georgia and northern Florida. By comparing the current stage (water-surface level above a datum) and predicted flood crest to the recorded peak stages of previous floods, emergency response personnel and residents can make informed decisions concerning the threat to life and property.

Flood-inundation map library for the Licking River and South Fork Licking River near Falmouth, Kentucky

USGS Publications Warehouse

Lant, Jeremiah G.

2016-09-19

Digital flood inundation maps for a 17-mile reach of Licking River and 4-mile reach of South Fork Licking River near Falmouth, Kentucky, were created by the U.S. Geological Survey (USGS) in cooperation with Pendleton County and the U.S. Army Corps of Engineers–Louisville District. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://wim.usgs.gov/FIMI/FloodInundationMapper.html, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Licking River at Catawba, Ky., (station 03253500) and the USGS streamgage on the South Fork Licking River at Hayes, Ky., (station 03253000). Current conditions (2015) for the USGS streamgages may be obtained online at the USGS National Water Information System site (http://waterdata.usgs.gov/nwis). In addition, the streamgage information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http:/water.weather.gov/ahps/). The flood hydrograph forecasts provided by the NWS are usually collocated with USGS streamgages. The forecasted peak-stage information, also available on the NWS Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation.In this study, flood profiles were computed for the Licking River reach and South Fork Licking River reach by using a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current (2015) stage-discharge relations for the Licking River at Catawba, Ky., and the South Fork Licking River at Hayes, Ky., USGS streamgages. The calibrated model was then used to calculate 60 water-surface profiles for a sequence of flood stages, at 2-foot intervals, referenced to the streamgage datum and ranging from an elevation near bankfull to the elevation associated with a major flood that occurred in the region in 1997. To delineate the flooded area at each interval flood stage, the simulated water-surface profiles were combined with a digital elevation model of the study area by using geographic information system software.The availability of these flood inundation maps for Falmouth, Ky., along with online information regarding current stages from the USGS streamgages and forecasted stages from the NWS, provides emergency management personnel and local residents with information that is critical for flood response activities such as evacuations, road closures, and post-flood recovery efforts.

Ricor's Nanostar water vapor compact cryopump: applications and model overview

NASA Astrophysics Data System (ADS)

Harris, Rodney S.; Nachman, Ilan; Tauber, Tomer; Kootzenko, Michael; Barak, Boris; Aminov, Eli; Gover, Dan

2017-05-01

Ricor Systems has developed a compact, single stage cryopump that fills the gap where GM and other type cryopumps can't fit in. Stirling cycle technology is highly efficient and is the primary cryogenic technology for use in IR, SWIR, HOT FPA, and other IR detector technology in military, security, and aerospace applications. Current GM based dual stage cryopumps have been the legacy type water vapor pumping system for more than 50 years. However, the typically large cryopanel head, compressor footprint, and power requirements make them not cost and use effective for small, tabletop evaporation / sputtering systems, portable analysis systems, and other systems requiring small volume vacuum creation from medium, high, and UHV levels. This single stage cryopump works well in-line with diffusion and molecular turbopumps. Studies have shown effective cooperation with non-evaporable getter technology as well for UHV levels. Further testing in this area are ongoing. Temperatures created by Stirling cycle cryogenic coolers develop a useful temperature range of 40 to 150K. Temperatures of approximately 100 K are sufficient to condense water and all hydrocarbons oil vapors.

Constant voltage and constant current control implementation for electric vehicles (evs) wireless charger

NASA Astrophysics Data System (ADS)

Tampubolon, Marojahan; Pamungkas, Laskar; Hsieh, Yao Ching; Chiu, Huang Jen

2018-04-01

This paper presents the implementation of Constant Voltage (CV) and Constant Current (CC) control for a wireless charger system. A battery charging system needs these control modes to ensure the safety of the battery and the effectiveness of the charging system. Here, the wireless charger system does not employ any post-regulator stage to control the output voltage and output current of the charger. But, it uses a variable frequency control incorporated with a conventional PI control. As a result, the size and the weight of the system are reduced. This paper discusses the brief review of the SS-WPT, control strategy and implementation of the CV and CC control. Experimental hardware with 2kW output power has been performed and tested. The results show that the proposed CV and CC control method works well with the system.

Advances in labor analgesia

PubMed Central

Wong, Cynthia A

2010-01-01

The pain of childbirth is arguably the most severe pain most women will endure in their lifetimes. The pain of the early first stage of labor arises from dilation of the lower uterine segment and cervix. Pain from the late first stage and second stage of labor arises from descent of the fetus in the birth canal, resulting in distension and tearing of tissues in the vagina and perineum. An array of regional nerve blocks, systemic analgesic, and nonpharmacologic techniques are currently used for labor analgesia. Nonpharmacologic methods are commonly used, but the effectiveness of these techniques generally lacks rigorous scientific study. Continuous labor support has been shown to decrease the use of pharmacologic analgesia and shorten labor. Intradermal water injections decrease back labor pain. Neuraxial labor analgesia (most commonly epidural or combined spinal-epidural) is the most effective method of pain relief during childbirth, and the only method that provides complete analgesia without maternal or fetal sedation. Current techniques commonly combine a low dose of local anesthetic (bupivacaine or ropivacaine) with a lipid soluble opioid (fentanyl or sufentanil). Neuraxial analgesia does not increase the rate of cesarean delivery compared to systemic opioid analgesia; however, dense neuraxial analgesia may increase the risk of instrumental vaginal delivery. PMID:21072284

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments.

PubMed

Trojan, Jörg; Zangos, Stephan; Schnitzbauer, Andreas A

2016-04-01

Hepatocellular carcinoma (HCC) is a frequent complication of liver cirrhosis. Worldwide, HCC is one of the most common cancers, with a rising incidence. A selective literature search was conducted, taking into account current studies, reviews, meta-analyses, and guidelines. The diagnosis is established either non-invasively by dynamic imaging, showing a typical contrast enhancement and wash-out, or histopathologically. Pathological diagnosis of HCC is recommended for all atypical nodules in patients with cirrhosis and for those in non-cirrhotic patients. Tumor therapy as well as treatment of the underlying chronic liver disease and/or preservation of liver function are important for the management of patients with HCC. Standard stage-adapted treatments are based on the widely applied Barcelona Clinic Liver Cancer staging system including liver resection and transplantation, interventional treatments such as thermal ablation and transarterial therapies, and systemic treatment with the tyrosine kinase inhibitor sorafenib. After failure of sorafenib, anti-angiogenic drugs, MET inhibitors, and immunotherapeutics are currently under advanced clinical investigation. Treatment of HCC is multidisciplinary and therefore requires a close cooperation between various disciplines such as hepatology, visceral surgery, radiology, and oncology to achieve the best outcome depending on the tumor stage and degree of liver function impairment.

Broad-beam high-current dc ion source based on a two-stage glow discharge plasma.

PubMed

Vizir, A V; Oks, E M; Yushkov, G Yu

2010-02-01

We have designed, made, and demonstrated a broad-beam, dc, ion source based on a two-stage, hollow-cathode, and glow discharges plasma. The first-stage discharge (auxiliary discharge) produces electrons that are injected into the cathode cavity of a second-stage discharge (main discharge). The electron injection causes a decrease in the required operating pressure of the main discharge down to 0.05 mTorr and a decrease in required operating voltage down to about 50 V. The decrease in operating voltage of the main discharge leads to a decrease in the fraction of impurity ions in the ion beam extracted from the main gas discharge plasma to less than 0.2%. Another feature of the source is a single-grid accelerating system in which the ion accelerating voltage is applied between the plasma itself and the grid electrode. The source has produced steady-state Ar, O, and N ion beams of about 14 cm diameter and current of more than 2 A at an accelerating voltage of up to 2 kV.

Luminescence evolution from alumina ceramic surface before flashover under direct and alternating current voltage in vacuum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Guo-Qiang; Wang, Yi-Bo; Song, Bai-Peng

2016-06-15

The luminescence evolution phenomena from alumina ceramic surface in vacuum under high voltage of direct and alternating current are reported, with the voltage covering a large range from far below to close to the flashover voltage. Its time resolved and spatial distributed behaviors are examined by a photon counting system and an electron-multiplying charge-coupled device (EMCCD) together with a digital camera, respectively. The luminescence before flashover exhibits two stages as voltage increasing, i.e., under a relative low voltage (Stage A), the luminescence is ascribed to radiative recombination of hetero-charges injected into the sample surface layer by Schottky effect; under amore » higher voltage (Stage B), a stable secondary electron emission process, resulting from the Fowler-Nordheim emission at the cathode triple junction (CTJ), is responsible for the luminescence. Spectrum analysis implies that inner secondary electrons within the surface layer of alumina generated during the SSEE process also participate in the luminescence of Stage B. A comprehensive interpretation of the flashover process is formulated, which might promote a better understanding of flashover issue in vacuum.« less

Luminescence evolution from alumina ceramic surface before flashover under direct and alternating current voltage in vacuum

NASA Astrophysics Data System (ADS)

Su, Guo-Qiang; Wang, Yi-Bo; Song, Bai-Peng; Mu, Hai-Bao; Zhang, Guan-Jun; Li, Feng; Wang, Meng

2016-06-01

The luminescence evolution phenomena from alumina ceramic surface in vacuum under high voltage of direct and alternating current are reported, with the voltage covering a large range from far below to close to the flashover voltage. Its time resolved and spatial distributed behaviors are examined by a photon counting system and an electron-multiplying charge-coupled device (EMCCD) together with a digital camera, respectively. The luminescence before flashover exhibits two stages as voltage increasing, i.e., under a relative low voltage (Stage A), the luminescence is ascribed to radiative recombination of hetero-charges injected into the sample surface layer by Schottky effect; under a higher voltage (Stage B), a stable secondary electron emission process, resulting from the Fowler-Nordheim emission at the cathode triple junction (CTJ), is responsible for the luminescence. Spectrum analysis implies that inner secondary electrons within the surface layer of alumina generated during the SSEE process also participate in the luminescence of Stage B. A comprehensive interpretation of the flashover process is formulated, which might promote a better understanding of flashover issue in vacuum.

Virtual Display Design and Evaluation of Clothing: A Design Process Support System

ERIC Educational Resources Information Center

Zhang, Xue-Fang; Huang, Ren-Qun

2014-01-01

This paper proposes a new computer-aided educational system for clothing visual merchandising and display. It aims to provide an operating environment that supports the various stages of display design in a user-friendly and intuitive manner. First, this paper provides a brief introduction to current software applications in the field of…

Development of a Diagnostic System for Information Ethics Education

ERIC Educational Resources Information Center

Shiota, Shingo; Sakai, Kyohei; Kobayashi, Keita

2016-01-01

This paper presents a new diagnostic system for information ethics education. In order to educate children about information ethics, it is necessary to know the stage at which they currently are in terms of their knowledge of the same. Some actual condition surveys have been conducted by the Cabinet Office and the National Police Agency to gauge…

PEG Enhancement for EM1 and EM2+ Missions

NASA Technical Reports Server (NTRS)

Von der Porten, Paul; Ahmad, Naeem; Hawkins, Matt

2018-01-01

NASA is currently building the Space Launch System (SLS) Block-1 launch vehicle for the Exploration Mission 1 (EM-1) test flight. The next evolution of SLS, the Block-1B Exploration Mission 2 (EM-2), is currently being designed. The Block-1 and Block-1B vehicles will use the Powered Explicit Guidance (PEG) algorithm. Due to the relatively low thrust-to-weight ratio of the Exploration Upper Stage (EUS), certain enhancements to the Block-1 PEG algorithm are needed to perform Block-1B missions. In order to accommodate mission design for EM-2 and beyond, PEG has been significantly improved since its use on the Space Shuttle program. The current version of PEG has the ability to switch to different targets during Core Stage (CS) or EUS flight, and can automatically reconfigure for a single Engine Out (EO) scenario, loss of communication with the Launch Abort System (LAS), and Inertial Navigation System (INS) failure. The Thrust Factor (TF) algorithm uses measured state information in addition to a priori parameters, providing PEG with an improved estimate of propulsion information. This provides robustness against unknown or undetected engine failures. A loft parameter input allows LAS jettison while maximizing payload mass. The current PEG algorithm is now able to handle various classes of missions with burn arcs much longer than were seen in the shuttle program. These missions include targeting a circular LEO orbit with a low-thrust, long-burn-duration upper stage, targeting a highly eccentric Trans-Lunar Injection (TLI) orbit, targeting a disposal orbit using the low-thrust Reaction Control System (RCS), and targeting a hyperbolic orbit. This paper will describe the design and implementation of the TF algorithm, the strategy to handle EO in various flight regimes, algorithms to cover off-nominal conditions, and other enhancements to the Block-1 PEG algorithm. This paper illustrates challenges posed by the Block-1B vehicle, and results show that the improved PEG algorithm is capable for use on the SLS Block 1-B vehicle as part of the Guidance, Navigation, and Control System.

A portable integrated system to control an active needle

NASA Astrophysics Data System (ADS)

Konh, Bardia; Motalleb, Mahdi; Ashrafiuon, Hashem

2017-04-01

The primary objective of this work is to introduce an integrated portable system to operate a flexible active surgical needle with actuation capabilities. The smart needle uses the robust actuation capabilities of the shape memory alloy wires to drastically improve the accuracy of in medical procedures such as brachytherapy. This, however, requires an integrated system aimed to control the insertion of the needle via a linear motor and its deflection by the SMA wire in real-time. The integrated system includes a flexible needle prototype, a Raspberry Pi computer, a linear stage motor, an SMA wire actuator, a power supply, electromagnetic tracking system, and various communication supplies. The linear stage motor guides the needle into tissue. The power supply provides appropriate current to the SMA actuator. The tracking system measures tip movement for feedback, The Raspberry Pi is the central tool that receives the tip movement feedback and controls the linear stage motor and the SMA actuator via the power supply. The implemented algorithms required for communication and feedback control are also described. This paper demonstrates that the portable integrated system may be a viable solution for more effective procedures requiring surgical needles.

Replacement of chemical rocket launchers by beamed energy propulsion.

PubMed

Fukunari, Masafumi; Arnault, Anthony; Yamaguchi, Toshikazu; Komurasaki, Kimiya

2014-11-01

Microwave Rocket is a beamed energy propulsion system that is expected to reach space at drastically lower cost. This cost reduction is estimated by replacing the first-stage engine and solid rocket boosters of the Japanese H-IIB rocket with Microwave Rocket, using a recently developed thrust model in which thrust is generated through repetitively pulsed microwave detonation with a reed-valve air-breathing system. Results show that Microwave Rocket trajectory, in terms of velocity versus altitude, can be designed similarly to the current H-IIB first stage trajectory. Moreover, the payload ratio can be increased by 450%, resulting in launch-cost reduction of 74%.

Observer-Pattern Modeling and Slow-Scale Bifurcation Analysis of Two-Stage Boost Inverters

NASA Astrophysics Data System (ADS)

Zhang, Hao; Wan, Xiaojin; Li, Weijie; Ding, Honghui; Yi, Chuanzhi

2017-06-01

This paper deals with modeling and bifurcation analysis of two-stage Boost inverters. Since the effect of the nonlinear interactions between source-stage converter and load-stage inverter causes the “hidden” second-harmonic current at the input of the downstream H-bridge inverter, an observer-pattern modeling method is proposed by removing time variance originating from both fundamental frequency and hidden second harmonics in the derived averaged equations. Based on the proposed observer-pattern model, the underlying mechanism of slow-scale instability behavior is uncovered with the help of eigenvalue analysis method. Then eigenvalue sensitivity analysis is used to select some key system parameters of two-stage Boost inverter, and some behavior boundaries are given to provide some design-oriented information for optimizing the circuit. Finally, these theoretical results are verified by numerical simulations and circuit experiment.

Flood-inundation maps for a 6.5-mile reach of the Kentucky River at Frankfort, Kentucky

USGS Publications Warehouse

Lant, Jeremiah G.

2013-01-01

Digital flood-inundation maps for a 6.5-mile reach of Kentucky River at Frankfort, Kentucky, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Frankfort Office of Emergency Management. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage Kentucky River at Lock 4 at Frankfort, Kentucky (station no. 03287500). Current conditions for the USGS streamgage may be obtained online at the USGS National Water Information System site (http://waterdata.usgs.gov/nwis/inventory?agency_code=USGS&site_no=03287500). In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http:/water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated at USGS streamgages. The forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the Kentucky River reach by using HEC–RAS, a one-dimensional step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the most current (2013) stage-discharge relation for the Kentucky River at Lock 4 at Frankfort, Kentucky, in combination with streamgage and high-water-mark measurements collected for a flood event in May 2010. The calibrated model was then used to calculate 26 water-surface profiles for a sequence of flood stages, at 1-foot intervals, referenced to the streamgage datum and ranging from a stage near bankfull to the elevation that breached the levees protecting the City of Frankfort. To delineate the flooded area at each interval flood stage, the simulated water-surface profiles were combined with a digital elevation model (DEM) of the study area by using geographic information system software. The DEM consisted of bare-earth elevations within the study area and was derived from a Light Detection And Ranging (LiDAR) dataset having a 5.0-foot horizontal resolution and an accuracy of 0.229 foot. The availability of these maps, along with Internet information regarding current stages from USGS streamgages and forecasted stages from the NWS, provides emergency management personnel and local residents with critical information for flood response activities such as evacuations, road closures, and postflood recovery efforts.

Flood-inundation maps for an 8.9-mile reach of the South Fork Little River at Hopkinsville, Kentucky

USGS Publications Warehouse

Lant, Jeremiah G.

2013-01-01

Digital flood-inundation maps for an 8.9-mile reach of South Fork Little River at Hopkinsville, Kentucky, were created by the U.S. Geological Survey (USGS) in cooperation with the City of Hopkinsville Community Development Services. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at South Fork Little River at Highway 68 By-Pass at Hopkinsville, Kentucky (station no. 03437495). Current conditions for the USGS streamgage may be obtained online at the USGS National Water Information System site (http://waterdata.usgs.gov/nwis/inventory?agency_code=USGS&site_no=03437495). In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often co-located at USGS streamgages. The forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the South Fork Little River reach by using HEC-RAS, a one-dimensional step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the most current (2012) stage-discharge relation at the South Fork Little River at Highway 68 By-Pass at Hopkinsville, Kentucky, streamgage and measurements collected during recent flood events. The calibrated model was then used to calculate 13 water-surface profiles for a sequence of flood stages, most at 1-foot intervals, referenced to the streamgage datum and ranging from a stage near bank full to the estimated elevation of the 1.0-percent annual exceedance probability flood at the streamgage. To delineate the flooded area at each interval flood stage, the simulated water-surface profiles were combined with a Digital Elevation Model (DEM) of the study area by using Geographic Information System (GIS) software. The DEM consisted of bare-earth elevations within the study area and was derived from a Light Detection And Ranging (LiDAR) dataset having a 3.28-foot horizontal resolution. These flood-inundation maps, along with online information regarding current stages from USGS streamgage and forecasted stages from the NWS, provide emergency management and local residents with critical information for flood response activities such as evacuations, road closures, and post-flood recovery efforts.

Flood-inundation maps for the East Fork White River at Shoals, Indiana

USGS Publications Warehouse

Boldt, Justin A.

2016-05-06

Digital flood-inundation maps for a 5.9-mile reach of the East Fork White River at Shoals, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the East Fork White River at Shoals, Ind. (USGS station number 03373500). Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service (AHPS) at http://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS AHPS site SHLI3). NWS AHPS forecast peak stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation.Flood profiles were computed for the East Fork White River reach by means of a one-dimensional, step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the current stage-discharge relation (USGS rating no. 43.0) at USGS streamgage 03373500, East Fork White River at Shoals, Ind. The calibrated hydraulic model was then used to compute 26 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum and ranging from approximately bankfull (10 ft) to the highest stage of the current stage-discharge rating curve (35 ft). The simulated water-surface profiles were then combined with a geographic information system (GIS) digital elevation model (DEM), derived from light detection and ranging (lidar) data, to delineate the area flooded at each water level. The areal extent of the 24-ft flood-inundation map was verified with photographs from a flood event on July 20, 2015.The availability of these maps, along with information on the Internet regarding current stage from the USGS streamgage at East Fork White River at Shoals, Ind., and forecasted stream stages from the NWS AHPS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Antiangiogenic treatment in hepatocellular carcinoma: the balance of efficacy and safety

PubMed Central

Welker, Martin-Walter; Trojan, Joerg

2013-01-01

Hepatocellular carcinoma (HCC) is a severe complication of advanced liver disease with a worldwide incidence of more than 600,000 patients per year. Liver function, clinical performance status, and tumor size are considered in the Barcelona Clinic Liver Cancer (BCLC) system. While curative treatment options are available for early stages, most patients present with intermediate- or advanced-stage HCC, burdened with a poor prognosis, substantially influenced by the degree of liver-function impairment. Hypervascularization is a major characteristic of HCC, and antiangiogenic treatments are the basis of treatment in noncurative stages, including interventional and pharmacological treatments. Currently, the tyrosine-kinase inhibitor sorafenib is still the only approved drug for HCC. Further improvements in survival in patients with intermediate- and advanced-stage HCC may be anticipated by both multimodal approaches, such as combination of interventional and systemic treatments, and new systemic treatment options. Until now, the Phase III development of other tyrosine-kinase inhibitors in patients with advanced HCC has failed due to minor efficacy and/or increased toxicity compared to sorafenib. However, promising Phase II data have been reported with MET inhibitors in this hard-to-treat population. This review gives a critical overview of antiangiogenic drugs and strategies in intermediate- and advanced-stage HCC, with a special focus on safety. PMID:24204170

Application of a hybrid generation/utility assessment heuristic to a class of scheduling problems

NASA Technical Reports Server (NTRS)

Heyward, Ann O.

1989-01-01

A two-stage heuristic solution approach for a class of multiobjective, n-job, 1-machine scheduling problems is described. Minimization of job-to-job interference for n jobs is sought. The first stage generates alternative schedule sequences by interchanging pairs of schedule elements. The set of alternative sequences can represent nodes of a decision tree; each node is reached via decision to interchange job elements. The second stage selects the parent node for the next generation of alternative sequences through automated paired comparison of objective performance for all current nodes. An application of the heuristic approach to communications satellite systems planning is presented.

Flood-inundation maps for the White River at Spencer, Indiana

USGS Publications Warehouse

Nystrom, Elizabeth A.

2013-01-01

Digital flood-inundation maps for a 5.3-mile reach of the White River at Spencer, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage White River at Spencer, Indiana (sta. no. 03357000). Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/. National Weather Service (NWS)-forecasted peak-stage inforamation may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relation at the White River at Spencer, Indiana, streamgage and documented high-water marks from the flood of June 8, 2008. The hydraulic model was then used to compute 20 water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum and ranging from the NWS action stage (9 feet) to the highest rated stage (28 feet) at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. The availability of these maps along with Internet information regarding the current stage from the Spencer USGS streamgage and forecasted stream stages from the NWS will provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

Coal systems analysis: A new approach to the understanding of coal formation, coal quality and environmental considerations, and coal as a source rock for hydrocarbons

USGS Publications Warehouse

Warwick, Peter D.

2005-01-01

Coal is an important and required energy source for today's world. Current rates of world coal consumption are projected to continue at approximately the same (or greater) levels well into the twenty-first century. This paper will provide an introduction to the concept of coal systems analysis and the accompanying volume of papers will provide examples of how coal systems analysis can be used to understand, characterize, and evaluate coal and coal gas resources. Coal systems analysis incorporates the various disciplines of coal geology to provide a complete characterization of the resource. The coal system is divided into four stages: (1) accumulation, (2) preservation-burial, (3) diagenesis-coalification, and (4) coal and hydrocarbon resources. These stages are briefly discussed and key references and examples of the application of coal systems analysis are provided.

Mars Sample Return Using Solar Sail Propulsion

NASA Technical Reports Server (NTRS)

Johnson, Les; Macdonald, Malcolm; Mcinnes, Colin; Percy, Tom

2012-01-01

Many Mars Sample Return (MSR) architecture studies have been conducted over the years. A key element of them is the Earth Return Stage (ERS) whose objective is to obtain the sample from the Mars Ascent Vehicle (MAV) and return it safely to the surface of the Earth. ERS designs predominantly use chemical propulsion [1], incurring a significant launch mass penalty due to the low specific impulse of such systems coupled with the launch mass sensitivity to returned mass. It is proposed to use solar sail propulsion for the ERS, providing a high (effective) specific impulse propulsion system in the final stage of the multi-stage system. By doing so to the launch mass of the orbiter mission can be significantly reduced and hence potentially decreasing mission cost. Further, solar sailing offers a unique set of non-Keplerian low thrust trajectories that may enable modifications to the current approach to designing the Earth Entry Vehicle by potentially reducing the Earth arrival velocity. This modification will further decrease the mass of the orbiter system. Solar sail propulsion uses sunlight to propel vehicles through space by reflecting solar photons from a large, mirror-like surface made of a lightweight, reflective material. The continuous photonic pressure provides propellantless thrust to conduct orbital maneuvering and plane changes more efficiently than conventional chemical propulsion. Because the Sun supplies the necessary propulsive energy, solar sails require no onboard propellant, thus reducing system mass. This technology is currently at TRL 7/8 as demonstrated by the 2010 flight of the Japanese Aerospace Exploration Agency, JAXA, IKAROS mission. [2

Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort.

PubMed

Marrero, Jorge A; Fontana, Robert J; Barrat, Ashley; Askari, Frederick; Conjeevaram, Hari S; Su, Grace L; Lok, Anna S

2005-04-01

Currently there is no consensus as to which staging system is best in predicting the survival of patients with hepatocellular carcinoma (HCC). The aims of this study were to identify independent predictors of survival and to compare 7 available prognostic staging systems in patients with HCC. A total of 239 consecutive patients with cirrhosis and HCC seen between January 1, 2000, and December 31, 2003, were included. Demographic, laboratory, and tumor characteristics and performance status were determined at diagnosis and before therapy. Predictors of survival were identified using the Kaplan-Meir test and the Cox model. Sixty-two percent of patients had hepatitis C, 56% had more than 1 tumor nodule, 24% had portal vein thrombosis, and 29% did not receive any cancer treatment. At the time of censorship, 153 (63%) patients had died. The 1- and 3-year survival of the entire cohort was 58% and 29%, respectively. The independent predictors of survival were performance status (P < .0001), MELD score greater than 10 (P = .001), portal vein thrombosis (P = .0001), and tumor diameter greater than 4 cm (P = .001). Treatment of HCC was related to overall survival. The Barcelona Clinic Liver Cancer (BCLC) staging system had the best independent predictive power for survival when compared with the other 6 prognostic systems. In conclusion, performance status, tumor extent, liver function, and treatment were independent predictors of survival mostly in patients with cirrhosis and HCC. The BCLC staging system includes aspects of all of these elements and provided the best prognostic stratification for our cohort of patients with HCC.

Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma.

PubMed

Sugawara, Kotaro; Yamashita, Hiroharu; Uemura, Yukari; Mitsui, Takashi; Yagi, Koichi; Nishida, Masato; Aikou, Susumu; Mori, Kazuhiko; Nomura, Sachiyo; Seto, Yasuyuki

2017-10-01

The current eighth tumor node metastasis lymph node category pathologic lymph node staging system for esophageal squamous cell carcinoma is based solely on the number of metastatic nodes and does not consider anatomic distribution. We aimed to assess the prognostic capability of the eighth tumor node metastasis pathologic lymph node staging system (numeric-based) compared with the 11th Japan Esophageal Society (topography-based) pathologic lymph node staging system in patients with esophageal squamous cell carcinoma. We retrospectively reviewed the clinical records of 289 patients with esophageal squamous cell carcinoma who underwent esophagectomy with extended lymph node dissection during the period from January 2006 through June 2016. We compared discrimination abilities for overall survival, recurrence-free survival, and cancer-specific survival between these 2 staging systems using C-statistics. The median number of dissected and metastatic nodes was 61 (25% to 75% quartile range, 45 to 79) and 1 (25% to 75% quartile range, 0 to 3), respectively. The eighth tumor node metastasis pathologic lymph node staging system had a greater ability to accurately determine overall survival (C-statistics: tumor node metastasis classification, 0.69, 95% confidence interval, 0.62-0.76; Japan Esophageal Society classification; 0.65, 95% confidence interval, 0.58-0.71; P = .014) and cancer-specific survival (C-statistics: tumor node metastasis classification, 0.78, 95% confidence interval, 0.70-0.87; Japan Esophageal Society classification; 0.72, 95% confidence interval, 0.64-0.80; P = .018). Rates of total recurrence rose as the eighth tumor node metastasis pathologic lymph node stage increased, while stratification of patients according to the topography-based node classification system was not feasible. Numeric nodal staging is an essential tool for stratifying the oncologic outcomes of patients with esophageal squamous cell carcinoma even in the cohort in which adequate numbers of lymph nodes were harvested. Copyright © 2017 Elsevier Inc. All rights reserved.

A Study of Three Phase and Single Phase High Frequency Distribution Systems

DTIC Science & Technology

1989-09-20

single Schwarz converter which operates in a variable frequency mode and acts as a regulated dc power supply . This mode of operation is used to maintain a...conditioning stages. The first stage contains a single Schwarz converter which operates in a variable frequency mode and acts as a regulated dc power supply ...dependent upon the amount of current ripple the capacitor must sink. This determines the capacitor heating since the power dissipated is equal to 2R

Progress in the planar CPn SOFC system design verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elangovan, S.; Hartvigsen, J.; Khandkar, A.

1996-04-01

SOFCo is developing a high efficiency, modular and scaleable planar SOFC module termed the CPn design. This design has been verified in a 1.4 kW module test operated directly on pipeline natural gas. The design features multistage oxidation of fuel wherein the fuel is consumed incrementally over several stages. High efficiency is achieved by uniform current density distribution per stage, which lowers the stack resistance. Additional benefits include thermal regulation and compactness. Test results from stack modules operating in pipeline natural gas are presented.

Cargo Container Imaging with Gaseous Detectors

NASA Astrophysics Data System (ADS)

Forest, Tony

2006-10-01

The gas electron multiplier (GEM) , developed at CERN by Fabio Sauli, represents the latest innovation in micropattern gaseous detectors and has been utilized as a preamplification stage in applications ranging from fundamental physics experiments to medical imaging. Although cargo container inspection systems are currently in place using gamma-rays or X-rays, they are predominantly designed with a resolution to detect contraband. Current imaging systems also suffer from false alarms due to naturally radioactive cargo when radiation portal monitors are used for passive detection of nuclear materials. Detection of small shielded radioactive elements is even more problematic. Idaho State University has been developing a system to image cargo containers in order to detect small shielded radioactive cargo. The possible application of an imaging system with gas electron multiplication will be shown along with preliminary images using gaseous detectors instead of the scintillators currently in use.

Downstream processing of antibodies: single-stage versus multi-stage aqueous two-phase extraction.

PubMed

Rosa, P A J; Azevedo, A M; Ferreira, I F; Sommerfeld, S; Bäcker, W; Aires-Barros, M R

2009-12-11

Single-stage and multi-stage strategies have been evaluated and compared for the purification of human antibodies using liquid-liquid extraction in aqueous two-phase systems (ATPSs) composed of polyethylene glycol 3350 (PEG 3350), dextran, and triethylene glycol diglutaric acid (TEG-COOH). The performance of single-stage extraction systems was firstly investigated by studying the effect of pH, TEG-COOH concentration and volume ratio on the partitioning of the different components of a Chinese hamster ovary (CHO) cells supernatant. It was observed that lower pH values and high TEG-COOH concentrations favoured the selective extraction of human immunoglobulin G (IgG) to the PEG-rich phase. Higher recovery yields, purities and percentage of contaminants removal were always achieved in the presence of the ligand, TEG-COOH. The extraction of IgG could be enhanced using higher volume ratios, however with a significant decrease in both purity and percentage of contaminants removal. The best single-stage extraction conditions were achieved for an ATPS containing 1.3% (w/w) TEG-COOH with a volume ratio of 2.2, which allowed the recovery of 96% of IgG in the PEG-rich phase with a final IgG concentration of 0.21mg/mL, a protein purity of 87% and a total purity of 43%. In order to enhance simultaneously both recovery yield and purity, a four stage cross-current operation was simulated and the corresponding liquid-liquid equilibrium (LLE) data determined. A predicted optimised scheme of a counter-current multi-stage aqueous two-phase extraction was hence described. IgG can be purified in the PEG-rich top phase with a final recovery yield of 95%, a final concentration of 1.04mg/mL and a protein purity of 93%, if a PEG/dextran ATPS containing 1.3% (w/w) TEG-COOH, 5 stages and volume ratio of 0.4 are used. Moreover, according to the LLE data of all CHO cells supernatant components, it was possible to observe that most of the cells supernatant contaminants can be removed during this extraction step leading to a final total purity of about 85%.

Policy implications in developing a land use management information systems

NASA Technical Reports Server (NTRS)

Landini, A. J.

1975-01-01

The current land use map for the city of Los Angeles was developed by the guesstimation process and provides single stage information for each level in the critical geographical hierarchy for land use planning management. Processing and incorporation of LANDSAT data in the land use information system requires special funding; however, computergraphic maps are able to provide a viable information system for city planning and management.

Design and implementation of location-based wireless targeted advertising

NASA Astrophysics Data System (ADS)

Li, Benjamin; Xu, Deyin

2001-10-01

As advertisements are time and location sensitive, a challenge for wireless marketing is to have advertisements delivered when and where they are most convenient. In this paper we introduce a two-stage auction model for location-based wireless targeted advertising. This system extends the notion of location-based service by using location information to target advertising, and does so specifically by enabling advertisers to specify their preferences and bid for advertisement delivery, where those preferences are then used in a subsequent automated auction of actual deliveries to wireless data users. The automated auction in the second stage is especially effective because it can use information about the individual user profile data, including customer relationship management system contents as well as location from the wireless system's location management service, including potentially location history such as current trajectory from recent history and longer-term historical trip records for that user. Through two-stage auction, real-time bidding by advertisers and matching ads contents to mobile users help advertising information reach maximal value.

Shielding Development for Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Caffrey, Jarvis A.; Gomez, Carlos F.; Scharber, Luke L.

2015-01-01

Radiation shielding analysis and development for the Nuclear Cryogenic Propulsion Stage (NCPS) effort is currently in progress and preliminary results have enabled consideration for critical interfaces in the reactor and propulsion stage systems. Early analyses have highlighted a number of engineering constraints, challenges, and possible mitigating solutions. Performance constraints include permissible crew dose rates (shared with expected cosmic ray dose), radiation heating flux into cryogenic propellant, and material radiation damage in critical components. Design strategies in staging can serve to reduce radiation scatter and enhance the effectiveness of inherent shielding within the spacecraft while minimizing the required mass of shielding in the reactor system. Within the reactor system, shield design is further constrained by the need for active cooling with minimal radiation streaming through flow channels. Material selection and thermal design must maximize the reliability of the shield to survive the extreme environment through a long duration mission with multiple engine restarts. A discussion of these challenges and relevant design strategies are provided for the mitigation of radiation in nuclear thermal propulsion.

Automated eddy current inspection of Space Shuttle APU turbine wheel blades

NASA Technical Reports Server (NTRS)

Fisher, Jay L.; Rowland, Stephen N.; Stolte, Jeffrey S.; Salkowski, Charles

1991-01-01

An automated inspection system based on eddy current testing (ET) techniques has been developed to inspect turbine wheel blades on the APU used in NASA's Space Transportation system. The APU is a hydrazine-powered gas turbine with a 15-cm diameter Rene 41 turbine wheel, which has 123 first-stage blades and 123 second-stage blades. The flaw detection capability of the ET system is verified through comparison with fluorescent penetrant test results. Results of the comparison indicate that ET is capable of inspecting surfaces with very restrictive geometries. The ET capability requires development of probes with extremely small coils to allow inspection within 0.4 mm of the blade root and the leading and trailing edges of the blade and within a height restriction of less than 1 mm. The color 2D presentation of the ET data provided crack-growth pattern and length information similar to those found with visual techniques. It also provided visual clues to minimize geometry effects such as generated from blade edges, a neighoring blade, and changes in the blade thickness.

A Retrospective Survival Analysis of Anatomic and Prognostic Stage Group Based on the American Joint Committee on Cancer 8th Edition Cancer Staging Manual in Luminal B Human Epidermal Growth Factor Receptor 2-negative Breast Cancer.

PubMed

Xu, Ling; Li, Jiang-Hong; Ye, Jing-Ming; Duan, Xue-Ning; Cheng, Yuan-Jia; Xin, Ling; Liu, Qian; Zhou, Bin; Liu, Yin-Hua

2017-08-20

Current understanding of tumor biology suggests that breast cancer is a group of diseases with different intrinsic molecular subtypes. Anatomic staging system alone is insufficient to provide future outcome information. The American Joint Committee on Cancer (AJCC) expert panel updated the 8th edition of the staging manual with prognostic stage groups by incorporating biomarkers into the anatomic stage groups. In this study, we retrospectively analyzed the data from our center in China using the anatomic and prognostic staging system based on the AJCC 8th edition staging manual. We reviewed the data from January 2008 to December 2014 for cases with Luminal B Human Epidermal Growth Factor Receptor 2 (HER2)-negative breast cancer in our center. All cases were restaged using the AJCC 8th edition anatomic and prognostic staging system. The Kaplan-Meier method and log-rank test were used to compare the survival differences between different subgroups. SPSS software version 19.0 (IBM Corp., Armonk, NY, USA) was used for the statistical analyses. This study consisted of 796 patients with Luminal B HER-negative breast cancer. The 5-year disease-free survival (DFS) of 769 Stage I-III patients was 89.7%, and the 5-year overall survival (OS) of all 796 patients was 91.7%. Both 5-year DFS and 5-year OS were significantly different in the different anatomic and prognostic stage groups. There were 372 cases (46.7%) assigned to a different group. The prognostic Stage II and III patients restaged from anatomic Stage III had significant differences in 5-year DFS (χ2 = 11.319, P= 0.001) and 5-year OS (χ2 = 5.225, P= 0.022). In addition, cases restaged as prognostic Stage I, II, or III from the anatomic Stage II group had statistically significant differences in 5-year DFS (χ2 = 6.510, P= 0.039) but no significant differences in 5-year OS (χ2 = 5.087, P= 0.079). However, the restaged prognostic Stage I and II cases from anatomic Stage I had no statistically significant differences in either 5-year DFS (χ2 = 0.440, P= 0.507) or 5-year OS (χ2 = 1.530, P= 0.216). The prognostic staging system proposed in the AJCC 8th edition refines the anatomic stage group in Luminal B HER2-negative breast cancer and will lead to a more personalized approach to breast cancer treatment.

Flood-inundation maps for Sweetwater Creek from above the confluence of Powder Springs Creek to the Interstate 20 bridge, Cobb and Douglas Counties, Georgia

USGS Publications Warehouse

Musser, Jonathan W.

2012-01-01

Digital flood-inundation maps for a 10.5-mile reach of Sweetwater Creek, from about 1,800 feet above the confluence of Powder Springs Creek to about 160 feet below the Interstate 20 bridge, were developed by the U.S. Geological Survey (USGS) in cooperation with Cobb County, Georgia. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Sweetwater Creek near Austell, Georgia (02337000). Current stage at this USGS streamgage may be obtained at http://waterdata.usgs.gov/ and can be used in conjunction with these maps to estimate near real-time areas of inundation. The National Weather Service (NWS) is incorporating results from this study into the Advanced Hydrologic Prediction Service (AHPS) flood-warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that commonly are collocated at USGS streamgages. The forecasted peak-stage information for the USGS streamgage at Sweetwater Creek near Austell (02337000), which is available through the AHPS Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. A one-dimensional step-backwater model was developed using the U.S. Army Corps of Engineers Hydrologic Engineering Centers River Analysis System (HEC–RAS) software for Sweetwater Creek and was used to compute flood profiles for a 10.5-mile reach of the creek. The model was calibrated using the most current stage-discharge relations at the Sweetwater Creek near Austell streamgage (02337000), as well as high-water marks collected during annual peak-flow events in 1982 and 2009. The hydraulic model was then used to determine 21 water-surface profiles for flood stages at the Sweetwater Creek streamgage at 1-foot intervals referenced to the streamgage datum and ranging from just above bankfull stage (12.0 feet) to approximately 1.2 feet above the highest recorded water level at the streamgage (32.0 feet). The simulated water-surface profiles were then combined with a geographic information system digital elevation model—derived from contour data (8-foot horizontal resolution), in Cobb County, and USGS National Elevation Dataset (31-foot horizontal resolution), in Douglas County—to delineate the area flooded for each 1-foot increment of stream stage. The availability of these maps, when combined with real-time information regarding current stage from USGS streamgages and forecasted stream stages from the NWS, provides emergency management personnel and residents with critical information during flood-response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

Flood-inundation maps for the Elkhart River at Goshen, Indiana

USGS Publications Warehouse

Strauch, Kellan R.

2013-01-01

The U.S. Geological Survey (USGS), in cooperation with the Indiana Office of Community and Rural Affairs, created digital flood-inundation maps for an 8.3-mile reach of the Elkhart River at Goshen, Indiana, extending from downstream of the Goshen Dam to downstream from County Road 17. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to nine selected water levels (stages) at the USGS streamgage at Elkhart River at Goshen (station number 04100500). Current conditions for the USGS streamgages in Indiana may be obtained on the Internet at http://waterdata.usgs.gov/. In addition, stream stage data have been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. NWS-forecasted peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relation at the Elkhart River at Goshen streamgage. The hydraulic model was then used to compute nine water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum and ranging from approximately bankfull (5 ft) to greater than the highest recorded water level (13 ft). The simulated water-surface profiles were then combined with a geographic information system (GIS) digital-elevation model (DEM), derived from Light Detection and Ranging (LiDAR) data having a 0.37-ft vertical accuracy and 3.9-ft horizontal resolution in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from USGS streamgages and forecasted stream stages from the NWS, provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for postflood recovery efforts.

Single-stage-to-orbit: Meeting the challenge

NASA Astrophysics Data System (ADS)

Freeman, Delma C., Jr.; Talay, Theodore A.; Austin, Robert Eugene

1995-10-01

There has been and continues to be significant discussion about the viability of fully reusable, single-stage-to-orbit (SSTO) concepts for delivery of payloads to orbit. Often, these discussions have focused in detail on performance and technology requirements relating to the technical feasibility of the concept, with only broad generalizations on how the SSTO will achieve its economic goals of greatly reduced vehicle ground and flight operations costs. With the current industry and NASA Reusable Launch Vehicle Technology Program efforts underway to mature and demonstrate technologies leading to a viable commercial launch system that also satisfies national needs, achieving acceptable recurring costs becomes a significant challenge. This paper reviews the current status of the Reusable Launch Vehicle Technology Program including the DC-XA, X-33, and X-34 flight systems and associated technology programs. The paper also examines lessons learned from the recently completed DC-X reusable rocket demonstrator program. It examines how these technologies and flight systems address the technical and operability challenges of SSTO whose solutions are necessary to reduce costs. The paper also discusses the management and operational approaches that address the challenge of a new cost-effective, reusable launch vehicle system.

Single-stage-to-orbit — Meeting the challenge

NASA Astrophysics Data System (ADS)

Freeman, Delma C.; Talay, Theodore A.; Austin, Robert Eugene

1996-02-01

There has been and continues to be significant discussion about the viability of fully reusable, single-stage-to-orbit (SSTO) concepts for delivery of payloads to orbit. Often, these discussions have focused in detail on performance and technology requirements relating to the technical feasibility of the concept, with only broad generalizations on how the SSTO will achieve its economic goals of greatly reduced vehicle ground and flight operations costs. With the current industry and NASA Reusable Launch Vehicle Technology Program efforts underway to mature and demonstrate technologies leading to a viable commercial launch system that also satisfies national needs, achieving acceptable recurring costs becomes a significant challenge. This paper reviews the current status of the Reusable Launch Vehicle Technology Program including the DC-XA, X-33, X-34 flight systems and associated technology programs. The paper also examines lessons learned from the recently completed DC-X reusable rocket demonstrator program. It examines how these technologies and flight systems address the technical and operability challenges of SSTO whose solutions are necessary to reduce costs. The paper also discusses the management and operational approaches that address the challenge of a new cost-effective, reusable launch vehicle system.

Space Launch System Mission Flexibility Assessment

NASA Technical Reports Server (NTRS)

Monk, Timothy; Holladay, Jon; Sanders, Terry; Hampton, Bryan

2012-01-01

The Space Launch System (SLS) is envisioned as a heavy lift vehicle that will provide the foundation for future beyond low Earth orbit (LEO) missions. While multiple assessments have been performed to determine the optimal configuration for the SLS, this effort was undertaken to evaluate the flexibility of various concepts for the range of missions that may be required of this system. These mission scenarios include single launch crew and/or cargo delivery to LEO, single launch cargo delivery missions to LEO in support of multi-launch mission campaigns, and single launch beyond LEO missions. Specifically, we assessed options for the single launch beyond LEO mission scenario using a variety of in-space stages and vehicle staging criteria. This was performed to determine the most flexible (and perhaps optimal) method of designing this particular type of mission. A specific mission opportunity to the Jovian system was further assessed to determine potential solutions that may meet currently envisioned mission objectives. This application sought to significantly reduce mission cost by allowing for a direct, faster transfer from Earth to Jupiter and to determine the order-of-magnitude mass margin that would be made available from utilization of the SLS. In general, smaller, existing stages provided comparable performance to larger, new stage developments when the mission scenario allowed for optimal LEO dropoff orbits (e.g. highly elliptical staging orbits). Initial results using this method with early SLS configurations and existing Upper Stages showed the potential of capturing Lunar flyby missions as well as providing significant mass delivery to a Jupiter transfer orbit.

Development and usability testing of FOCUS: a smartphone system for self-management of schizophrenia.

PubMed

Ben-Zeev, Dror; Kaiser, Susan M; Brenner, Christopher J; Begale, Mark; Duffecy, Jennifer; Mohr, David C

2013-12-01

Mobile Health (mHealth) approaches can support the rehabilitation of individuals with psychiatric conditions. In the current article, we describe the development of a smartphone illness self-management system for people with schizophrenia. The research was conducted with consumers and practitioners at a community-based rehabilitation agency. Stage 1: 904 individuals with schizophrenia or schizoaffective disorder completed a survey reporting on their current use of mobile devices and interest in mHealth services. Eight practitioners completed a survey examining their attitudes and expectations from an mHealth intervention, and identified needs and potential obstacles. Stage 2: A multidisciplinary team incorporated consumer and practitioner input and employed design principles for the development of e-resources for people with schizophrenia to produce an mHealth intervention. Stage 3: 12 consumers participated in laboratory usability sessions. They performed tasks involved in operating the new system, and provided "think aloud" commentary and post-session usability ratings. 570 (63%) of survey respondents reported owning a mobile device and many expressed interest in receiving mHealth services. Most practitioners believed that consumers could learn to use and would benefit from an mHealth intervention. In response, we developed a smartphone system that targets medication adherence, mood regulation, sleep, social functioning, and coping with symptoms. Usability testing revealed several design vulnerabilities, and the system was adapted to address consumer needs and preferences accordingly. Through a comprehensive development process, we produced an mHealth illness self-management intervention that is likely to be used successfully, and is ready for deployment and systemic evaluation in real-world conditions. PsycINFO Database Record (c) 2013 APA, all rights reserved.

High-numerical aperture extreme ultraviolet scanner for 8-nm lithography and beyond

NASA Astrophysics Data System (ADS)

Schoot, Jan van; Setten, Eelco van; Rispens, Gijsbert; Troost, Kars Z.; Kneer, Bernhard; Migura, Sascha; Neumann, Jens Timo; Kaiser, Winfried

2017-10-01

Current extreme ultraviolet (EUV) projection lithography systems exploit a projection lens with a numerical aperture (NA) of 0.33. It is expected that these will be used in mass production in the 2018/2019 timeframe. By then, the most difficult layers at the 7-nm logic and the mid-10-nm DRAM nodes will be exposed. These systems are a more economical alternative to multiple-exposure by 193 argon fluoride immersion scanners. To enable cost-effective shrink by EUV lithography down to 8-nm half pitch, a considerably larger NA is needed. As a result of the increased NA, the incidence angles of the light rays at the mask increase significantly. Consequently, the shadowing and the variation of the multilayer reflectivity deteriorate the aerial image contrast to unacceptably low values at the current 4× magnification. The only solution to reduce the angular range at the mask is to increase the magnification. Simulations show that the magnification has to be doubled to 8× to overcome the shadowing effects. Assuming that the mask infrastructure will not change the mask form factor, this would inevitably lead to a field size that is a quarter of the field size of the current 0.33-NA step and scan systems and reduce the throughput (TPT) of the high-NA scanner to a value below 100 wafers per hour unless additional measures are taken. This paper presents an anamorphic step and scan system capable of printing fields that are half the field size of the current full field. The anamorphic system has the potential to achieve a TPT in excess of 150 wafers per hour by increasing the transmission of the optics, as well as increasing the acceleration of the wafer stage and mask stage. This makes it an economically viable lithography solution.

Racial disparity in survival from early breast cancer in the department of defense healthcare system.

PubMed

Rizzo, Julie A; Sherman, William E; Arciero, Cletus A

2015-06-01

Racial disparity is often identified as a factor in survival from breast cancer in the United States. Current data regarding survival in patients treated in the Department of Defense Military Healthcare System is lacking. The Department of Defense Automated Central Tumor Registry (ACTUR) was queried for all women diagnosed with Stage I or II breast cancer from January 1, 1996 through December 31, 2008. Statistical analyses evaluated demographics, surgical treatment, tumor stage, and survival rates. There were 8,890 patients meeting inclusion criteria. Patients who were younger, Asian American (versus white or black), lower T and/or N stage had significantly improved survival rates. Interestingly, white and black patients demonstrated similar survival in this study. Patients with a longer period of time between diagnosis and treatment had no decrement in survival. As would be expected, patients with a longer recurrence free period enjoyed longer survival. Survival from early stage breast cancer is equivalent between white and black patients in the Department of Defense Healthcare System. This finding is contrary to reports from our civilian counterparts and may be indicative of improved access to care and overall improved cancer surveillance. © 2015 Wiley Periodicals, Inc.

Flood inundation maps for the Wabash and Eel Rivers at Logansport, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.

2014-01-01

Digital flood-inundation maps for an 8.3-mile reach of the Wabash River and a 7.6-mile reach of the Eel River at Logansport, Indiana (Ind.), were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at USGS streamgage Wabash River at Logansport, Ind. (sta. no. 03329000) and USGS streamgage Eel River near Logansport, Ind. (sta. no. 03328500). Current conditions for estimating near-real-time areas of inundation using USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/. In addition, information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system http:/water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. NWS-forecasted peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. For this study, flood profiles were computed for the stream reaches by means of a one-dimensional step-backwater model developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated by using the most current stage-discharge relations at USGS streamgages 03329000, Wabash River at Logansport, Ind., and 03328500, Eel River near Logansport, Ind. The calibrated hydraulic model was then used to determine five water-surface profiles for flood stage at 1-foot intervals referenced to the Wabash River streamgage datum, and four water-surface profiles for flood stages at 1-foot intervals referenced to the Eel River streamgage datum. The stages range from bankfull to approximately the highest stages that have occurred since 1967 when three flood control dams were built upstream of Logansport, Ind. The simulated water-surface profiles were then combined with a geographic information system (GIS) digital elevation model (DEM, derived from Light Detection and Ranging [lidar] data having a 0.37-foot vertical accuracy and 3.9-foot horizontal resolution) in order to delineate the area flooded at each stage. The availability of these maps, along with information available on the Internet regarding current stages from the USGS streamgages at Logansport, Ind., and forecasted stream stages from the NWS, provides emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post flood recovery efforts.

Two-stage single-phase grid-connected photovoltaic system with reduced complexity

NASA Astrophysics Data System (ADS)

da Silva, Cintia S.; Motta, Filipe R.; Tofoli, Fernando L.

2011-06-01

This article presents a grid-connected photovoltaic (PV) system using the classical DC-DC buck converter, which is responsible for stepping down the resulting voltage from several series-connected panels. Besides, the structure provides high power factor operation by injecting a quasi-sinusoidal current into the grid, with near no displacement in relation to the line voltage at the point of common coupling among the PV system and the loads. A CSI employing thyristors is cascaded with the DC-DC stage so that AC voltage results. The inverter output voltage level is adjusted by using a low-frequency transformer, which also provides galvanic isolation. The proposed system is described as mathematical approach and design guidelines are presented, providing an overview of the topology. An experimental prototype is also implemented, and relevant results to validate the proposal are discussed.

Advanced Manned Launch System (AMLS) study

NASA Technical Reports Server (NTRS)

Ehrlich, Carl F., Jr.; Potts, Jack; Brown, Jerry; Schell, Ken; Manley, Mary; Chen, Irving; Earhart, Richard; Urrutia, Chuck; Randolph, Ray; Morris, Jim

1992-01-01

To assure national leadership in space operations and exploration in the future, NASA must be able to provide cost effective and operationally efficient space transportation. Several NASA studies and the joint NASA/DoD Space Transportation Architecture Studies (STAS) have shown the need for a multi-vehicle space transportation system with designs driven by enhanced operations and low costs. NASA is currently studying an advanced manned launch system (AMLS) approach to transport crew and cargo to the Space Station Freedom. Several single and multiple stage systems from air-breathing to all-rocket concepts are being examined in a series of studies potential replacements for the Space Shuttle launch system in the 2000-2010 time frame. Rockwell International Corporation, under contract to the NASA Langley Research Center, has analyzed a two-stage all-rocket concept to determine whether this class of vehicles is appropriate for the AMLS function. The results of the pre-phase A study are discussed.

Natural Oil Production from Microorganisms: Bioprocess and Microbe Engineering for Total Carbon Utilization in Biofuel Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-07-15

Electrofuels Project: MIT is using carbon dioxide (CO2) and hydrogen generated from electricity to produce natural oils that can be upgraded to hydrocarbon fuels. MIT has designed a 2-stage biofuel production system. In the first stage, hydrogen and CO2 are fed to a microorganism capable of converting these feedstocks to a 2-carbon compound called acetate. In the second stage, acetate is delivered to a different microorganism that can use the acetate to grow and produce oil. The oil can be removed from the reactor tank and chemically converted to various hydrocarbons. The electricity for the process could be supplied frommore » novel means currently in development, or more proven methods such as the combustion of municipal waste, which would also generate the required CO2 and enhance the overall efficiency of MIT’s biofuel-production system.« less

Reconciling Scratch Space Consumption, Exposure, and Volatility to Achieve Timely Staging of Job Input Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monti, Henri; Butt, Ali R; Vazhkudai, Sudharshan S

2010-04-01

Innovative scientific applications and emerging dense data sources are creating a data deluge for high-end computing systems. Processing such large input data typically involves copying (or staging) onto the supercomputer's specialized high-speed storage, scratch space, for sustained high I/O throughput. The current practice of conservatively staging data as early as possible makes the data vulnerable to storage failures, which may entail re-staging and consequently reduced job throughput. To address this, we present a timely staging framework that uses a combination of job startup time predictions, user-specified intermediate nodes, and decentralized data delivery to coincide input data staging with job start-up.more » By delaying staging to when it is necessary, the exposure to failures and its effects can be reduced. Evaluation using both PlanetLab and simulations based on three years of Jaguar (No. 1 in Top500) job logs show as much as 85.9% reduction in staging times compared to direct transfers, 75.2% reduction in wait time on scratch, and 2.4% reduction in usage/hour.« less

The AAS Working Group on Accessibility and Disability (WGAD): progress, current projects, and prospects for making astronomy accessible to all

NASA Astrophysics Data System (ADS)

Aarnio, Alicia; Diaz-Merced, Wanda; Monkiewicz, Jacqueline; Knierman, Karen; AAS WGAD

2018-01-01

Representation of astronomers with disabilities is low at the earliest career stages and losses compound with career stage thereafter; single-digit and lower percentage representation statistics are in large part due to systemic barriers to access and failure to accommodate the needs of users of a wide range of abilities. In this presentation, we discuss the barriers currently inhibiting broad access to astronomical publications, databases, and conferences. The WGAD was formed in January of 2016 to work toward removal of these barriers to make our field inclusive of astronomers with disabilities at all career stages. We have productively engaged with publishers and accessibility audits have been performed. Database accessibility evaluation is underway, and we are working with the AAS and other professional organizations on conference accessibility. We are keeping users centrally focused via surveys and user test groups, and holding paramount the overarching idea that meeting present accessibility standards is a necessary but insufficient condition for full access.

Feasibility study for long lifetime helium dewar

NASA Technical Reports Server (NTRS)

Parmley, R. T.

1981-01-01

A feasible concept for a launchable three year lifetime helium dewar was investigted. Current helium dewar designs were examined to see where the largest potential reductions in parasitic heat loads can be made. The study was also devoted to examining support concepts. The support concept chosen, a passive orbital disconnect strut (PODS), has an orbital support conductance that is lower by more than an order of magnitude over current tension band supports. This lower support conductance cuts the total dewar weight in half for the same three year life time requirements. Effort was also concentrated on efficient wire feed through designs and vapor cooling of the multilayer insulation, supports, wire feed throughs and plumbing penetrations. A single stage helium dewar vs. dual stage dewars with a guard cryogen of nitrogen or neon was examined. The single stage dewar concept was selected. Different support concepts were analyzed from which the PODS support concepts was chosen. A preliminary design of the dewar was thermally and structurally analyzed and laid out including system weights, thermal performance and performance sensitivities.

Characteristics and causal factors of hysteresis in the hydrodynamics of a large floodplain system: Poyang Lake (China)

NASA Astrophysics Data System (ADS)

Zhang, X. L.; Zhang, Q.; Werner, A. D.; Tan, Z. Q.

2017-10-01

A previous modeling study of the lake-floodplain system of Poyang Lake (China) revealed complex hysteretic relationships between stage, storage volume and surface area. However, only hypothetical causal factors were presented, and the reasons for the occurrence of both clockwise and counterclockwise hysteretic functions were unclear. The current study aims to address this by exploring further Poyang Lake's hysteretic behavior, including consideration of stage-flow relationships. Remotely sensed imagery is used to validate the water surface areas produced by hydrodynamic modeling. Stage-area relationships obtained using the two methods are in strong agreement. The new results reveal a three-phase hydrological regime in stage-flow relationships, which assists in developing improved physical interpretation of hysteretic stage-area relationships for the lake-floodplain system. For stage-area relationships, clockwise hysteresis is the result of classic floodplain hysteretic processes (e.g., restricted drainage of the floodplain during recession), whereas counterclockwise hysteresis derives from the river hysteresis effect (i.e., caused by backwater effects). The river hysteresis effect is enhanced by the time lag between the peaks of catchment inflow and Yangtze discharge (i.e., the so-called Yangtze River blocking effect). The time lag also leads to clockwise hysteresis in the relationship between Yangtze River discharge and lake stage. Thus, factors leading to hysteresis in other rivers, lakes and floodplains act in combination within Poyang Lake to create spatial variability in hydrological hysteresis. These effects dominate at different times, in different parts of the lake, and during different phases of the lake's water level fluctuations, creating the unique hysteretic hydrological behavior of Poyang Lake.

The continuing problem of human African trypanosomiasis (sleeping sickness).

PubMed

Kennedy, Peter G E

2008-08-01

Human African trypanosomiasis, also known as sleeping sickness, is a neglected disease, and it continues to pose a major threat to 60 million people in 36 countries in sub-Saharan Africa. Transmitted by the bite of the tsetse fly, the disease is caused by protozoan parasites of the genus Trypanosoma and comes in two types: East African human African trypanosomiasis caused by Trypanosoma brucei rhodesiense and the West African form caused by Trypanosoma brucei gambiense. There is an early or hemolymphatic stage and a late or encephalitic stage, when the parasites cross the blood-brain barrier to invade the central nervous system. Two critical current issues are disease staging and drug therapy, especially for late-stage disease. Lumbar puncture to analyze cerebrospinal fluid will remain the only method of disease staging until reliable noninvasive methods are developed, but there is no widespread consensus as to what exactly defines biologically central nervous system disease or what specific cerebrospinal fluid findings should justify drug therapy for late-stage involvement. All four main drugs used for human African trypanosomiasis are toxic, and melarsoprol, the only drug that is effective for both types of central nervous system disease, is so toxic that it kills 5% of patients who receive it. Eflornithine, alone or combined with nifurtimox, is being used increasingly as first-line therapy for gambiense disease. There is a pressing need for an effective, safe oral drug for both stages of the disease, but this will require a significant increase in investment for new drug discovery from Western governments and the pharmaceutical industry.

Performance evaluation of two-stage fuel cycle from SFR to PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fei, T.; Hoffman, E.A.; Kim, T.K.

2013-07-01

One potential fuel cycle option being considered is a two-stage fuel cycle system involving the continuous recycle of transuranics in a fast reactor and the use of bred plutonium in a thermal reactor. The first stage is a Sodium-cooled Fast Reactor (SFR) fuel cycle with metallic U-TRU-Zr fuel. The SFRs need to have a breeding ratio greater than 1.0 in order to produce fissile material for use in the second stage. The second stage is a PWR fuel cycle with uranium and plutonium mixed oxide fuel based on the design and performance of the current state-of-the-art commercial PWRs with anmore » average discharge burnup of 50 MWd/kgHM. This paper evaluates the possibility of this fuel cycle option and discusses its fuel cycle performance characteristics. The study focuses on an equilibrium stage of the fuel cycle. Results indicate that, in order to avoid a positive coolant void reactivity feedback in the stage-2 PWR, the reactor requires high quality of plutonium from the first stage and minor actinides in the discharge fuel of the PWR needs to be separated and sent back to the stage-1 SFR. The electricity-sharing ratio between the 2 stages is 87.0% (SFR) to 13.0% (PWR) for a TRU inventory ratio (the mass of TRU in the discharge fuel divided by the mass of TRU in the fresh fuel) of 1.06. A sensitivity study indicated that by increasing the TRU inventory ratio to 1.13, The electricity generation fraction of stage-2 PWR is increased to 28.9%. The two-stage fuel cycle system considered in this study was found to provide a high uranium utilization (>80%). (authors)« less

[The development of a finger joint phantom for the optical simulation of early inflammatory rheumatic changes].

PubMed

Prapavat, V; Runge, W; Mans, J; Krause, A; Beuthan, J; Müller, G

1997-11-01

In the field of rheumatology, conventional diagnostic methods permit the detection only of advanced stages of the disease, which is at odds with the current clinical demand for the early diagnosis of inflammatory rheumatic diseases. Prompted by current needs, we developed a finger joint phantom that enables the optical and geometrical simulation of an early stage of rheumatoid arthritis (RA). The results presented here form the experimental basis for an evaluation of new RA diagnostic systems based on near infrared light. The early stage of RA is characterised mainly by a vigorous proliferation of the synovial membrane and clouding of the synovial fluid. Using a double-integrating-sphere technique, the absorption and scattering coefficients (mua, mus') are experimentally determined for healthy and pathologically altered synovial fluid and capsule tissue. Using a variable mixture of Intralipid Indian ink and water as a scattering/absorption medium, the optical properties of skin, synovial fluid or capsule can be selected individually. Since the optical and geometrical properties of bone tissue remain constant in early-stage RA, a solid material is used for its simulation. Using the finger joint phantom described herein, the optical properties of joint regions can be adjusted specifically, enabling an evaluation of their effects on an optical signal--for example, during fluorography--and the investigation of these effects for diagnostically useful information. The experimental foundation for the development of a new optical system for the early diagnosis of RA has now been laid.

Design and Development of a Methane Cryogenic Propulsion Stage for Human Mars Exploration

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; Polsgrove, Tara; Turpin, Jason; Alexander, Leslie

2016-01-01

NASA is currently working on the Evolvabe Mars Campaign (EMC) study to outline transportation and mission options for human exploration of Mars. One of the key aspects of the EMC is leveraging current and planned near-term technology investments to build an affordable and evolvable approach to Mars exploration. This leveraging of investments includes the use of high-power Solar Electric Propulsion (SEP) systems, evolved from those currently under development in support of the Asteroid Redirect Mission (ARM), to deliver payloads to Mars. The EMC is considering several transportation options that combine solar electric and chemical propulsion technologies to deliver crew and cargo to Mars. In one primary architecture option, the SEP propulsion system is used to pre-deploy mission elements to Mars while a high-thrust chemical propulsion system is used to send crew on faster ballistic transfers between Earth and Mars. This high-thrust chemical system uses liquid oxygen - liquid methane main propulsion and reaction control systems integrated into the Methane Cryogenic Propulsion Stage (MCPS). Over the past year, there have been several studies completed to provide critical design and development information related to the MCPS. This paper is intended to provide a summary of these efforts. A summary of the current point of departure design for the MCPS is provided as well as an overview of the mission architecture and concept of operations that the MCPS is intended to support. To leverage the capabilities of solar electric propulsion to the greatest extent possible, the EMC architecture pre-deploys to Mars orbit the stages required for returning crew from Mars. While this changes the risk posture of the architecture, it can provide some mass savings by using higher-efficiency systems for interplanetary transfer. However, this does introduce significantly longer flight times to Mars which, in turn, increases the overall lifetime of the stages to as long as 2500 days. This unique aspect to the concept of operations introduces several challenges, specifically related to propellant storage and engine reliability. These challenges and some potential solutions are discussed. Specific focus is provided on two key technology areas; propulsion and cryogenic fluid management. In the area of propulsion development, the development of an integrated methane propulsion system that combines both main propulsion and reaction control is discussed. This includes an overview of potential development paths, areas where development for Mars applications are complementary to development efforts underway in other parts of the aerospace industry, and commonality between the MCPS methane propulsion applications and other Mars elements, including the Mars lander systems. This commonality is a key affordability aspect of the Evolvable Mars Campaign. A similar discussion is provided for cryogenic fluid management technologies including a discussion of how using cryo propulsion in the Mars transportation application not only provides performance benefits but also leverages decades of technology development investments made by NASA and its aerospace contractor community.

Design and Development of a Methane Cryogenic Propulsion Stage for Human Mars Exploration

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; Polsgrove, Tara; Turpin, Jason; Alexander, Leslie

2016-01-01

NASA is currently working on the Evolvabe Mars Campaign (EMC) study to outline transportation and mission options for human exploration of Mars. One of the key aspects of the EMC is leveraging current and planned near-term technology investments to build an affordable and evolvable approach to Mars exploration. This leveraging of investments includes the use of high-power Solar Electric Propulsion (SEP) systems evolved from those currently under development in support of the Asteroid Redirect Mission to deliver payloads to Mars. The EMC is considering several transportation options that combine solar electric and chemical propulsion technologies to deliver crew and cargo to Mars. In one primary architecture option, the SEP propulsion system is used to pre-deploy mission elements to Mars while a high-thrust chemical propulsion system is used to send crew on faster ballistic transfers between Earth and Mars. This high-thrust chemical system uses liquid oxygen - liquid methane main propulsion and reaction control systems integrated into the Methane Cryogenic Propulsion Stage (MCPS). Over the past year, there have been several studies completed to provide critical design and development information related to the MCPS. This paper is intended to provide a summary of these efforts. A summary of the current point of departure design for the MCPS is provided as well as an overview of the mission architecture and concept of operations that the MCPS is intended to support. To leverage the capabilities of solar electric propulsion to the greatest extent possible, the EMC architecture pre-deploys the required stages for returning crew from Mars. While this changes the risk posture of the architecture, it provides mass savings by using higher-efficiency systems for interplanetary transfer. However, this does introduce significantly longer flight times to Mars which, in turn, increases the overall lifetime of the stages to as long as 3000 days. This unique aspect to the concept of operations introduces several challenges, specifically related to propellant storage and engine reliability. These challenges and some potential solutions are discussed. Specific focus is provided on two key technology areas; propulsion and cryogenic fluid management. In the area of propulsion development, the development of an integrated methane propulsion system that combines both main propulsion and reaction control is discussed. This includes an overview of potential development paths, areas where development for Mars applications are complementary to development efforts underway in other parts of the aerospace industry, and commonality between the MCPS methane propulsion applications and other Mars elements, including the Mars lander systems. This commonality is a key affordability aspect of the Evolvable Mars Campaign. A similar discussion is provided for cryogenic fluid management technologies including a discussion of how using cryo-propulsion in the Mars transportation application not only provides performance benefits but also leverages decades of technology development investments made by NASA and its aerospace contractor community.

Telerobotic on-orbit remote fluid resupply system

NASA Technical Reports Server (NTRS)

1990-01-01

The development of a telerobotic on-orbit fluid resupply demonstration system is described. A fluid transfer demonstration system was developed which functionally simulates operations required to remotely transfer fluids (liquids or gases) from a servicing spacecraft to a receiving spacecraft through the use of telerobotic manipulations. The fluid system is representative of systems used by current or planned spacecraft and propulsion stages requiring on-orbit remote resupply. The system was integrated with an existing MSFC remotely controlled manipulator arm to mate/demate couplings for demonstration and evaluation of a complete remotely operated fluid transfer system.

Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer.

PubMed

Davidson, Stacey M; Ko, Huasing C; Harari, Paul M; Wieland, Aaron M; Chen, Shuai; Baschnagel, Andrew M; Kimple, Randall J; Witek, And Matthew E

2018-04-01

Objective We evaluated the ability of the American Joint Committee on Cancer (AJCC) seventh edition staging system to prognosticate the overall survival of patients with human papillomavirus (HPV)-positive laryngeal squamous cell carcinoma. Study Design Retrospective analysis. Setting National Cancer Database. Subjects and Methods Patients diagnosed with laryngeal squamous cell carcinoma who were treated with curative intent were identified in the National Cancer Database. Multivariate analysis was utilized to determine factors correlated with overall survival in the HPV-negative and HPV-positive cohorts. Unadjusted and propensity score-weighted Kaplan-Meier estimation was used to determine overall survival of HPV-negative and HPV-positive patients across AJCC stage groupings. Results We identified 3238 patients with laryngeal squamous cell carcinoma, of which 2812 were HPV negative and 426 were HPV positive. Overall survival adjusted for age, sex, and comorbidity status confirmed significant differences among all consecutive stage groupings (I vs II, P < .001; II vs III, P < .05; III vs IVA, P < .001; IVA vs IVB, P < .05) in the HPV-negative cohort, whereas only stages IVAs and IVB ( P < .01) exhibited a significant difference in overall survival for HPV-positive patients. Conclusion The current AJCC staging system does not accurately distinguish risk of mortality for patients with HPV-positive disease. These data support the consideration of HPV status in estimating prognosis as well as clinical trial design and clinical decision making for patients with laryngeal squamous cell carcinoma.

Protein extraction and gel-based separation methods to analyze responses to pathogens in carnation (Dianthus caryophyllus L).

PubMed

Ardila, Harold Duban; Fernández, Raquel González; Higuera, Blanca Ligia; Redondo, Inmaculada; Martínez, Sixta Tulia

2014-01-01

We are currently using a 2-DE-based proteomics approach to study plant responses to pathogenic fungi by using the carnation (Dianthus caryophyllus L)-Fusarium oxysporum f. sp. dianthi pathosystem. It is clear that the protocols for the first stages of a standard proteomics workflow must be optimized to each biological system and objectives of the research. The optimization procedure for the extraction and separation of proteins by 1-DE and 2-DE in the indicated system is reported. This strategy can be extrapolated to other plant-pathogen interaction systems in order to perform an evaluation of the changes in the host protein profile caused by the pathogen and to identify proteins which, at early stages, are involved or implicated in the plant defense response.

AQUATOOL, a generalized decision-support system for water-resources planning and operational management

NASA Astrophysics Data System (ADS)

Andreu, J.; Capilla, J.; Sanchís, E.

1996-04-01

This paper describes a generic decision-support system (DSS) which was originally designed for the planning stage of dicision-making associated with complex river basins. Subsequently, it was expanded to incorporate modules relating to the operational stage of decision-making. Computer-assisted design modules allow any complex water-resource system to be represented in graphical form, giving access to geographically referenced databases and knowledge bases. The modelling capability includes basin simulation and optimization modules, an aquifer flow modelling module and two modules for risk assessment. The Segura and Tagus river basins have been used as case studies in the development and validation phases. The value of this DSS is demonstrated by the fact that both River Basin Agencies currently use a version for the efficient management of their water resources.

Design and experiment of vehicular charger AC/DC system based on predictive control algorithm

NASA Astrophysics Data System (ADS)

He, Guangbi; Quan, Shuhai; Lu, Yuzhang

2018-06-01

For the car charging stage rectifier uncontrollable system, this paper proposes a predictive control algorithm of DC/DC converter based on the prediction model, established by the state space average method and its prediction model, obtained by the optimal mathematical description of mathematical calculation, to analysis prediction algorithm by Simulink simulation. The design of the structure of the car charging, at the request of the rated output power and output voltage adjustable control circuit, the first stage is the three-phase uncontrolled rectifier DC voltage Ud through the filter capacitor, after by using double-phase interleaved buck-boost circuit with wide range output voltage required value, analyzing its working principle and the the parameters for the design and selection of components. The analysis of current ripple shows that the double staggered parallel connection has the advantages of reducing the output current ripple and reducing the loss. The simulation experiment of the whole charging circuit is carried out by software, and the result is in line with the design requirements of the system. Finally combining the soft with hardware circuit to achieve charging of the system according to the requirements, experimental platform proved the feasibility and effectiveness of the proposed predictive control algorithm based on the car charging of the system, which is consistent with the simulation results.

Dynamics of the plasma current sheath in plasma focus discharges in different gases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinogradov, V. P.; Krauz, V. I., E-mail: krauz-vi@nrcki.ru; Mokeev, A. N.

2016-12-15

The shape of the plasma current sheath (PCS) in the final stage of its radial compression, the dynamics of pinching, and the subsequent pinch decay in plasma focus (PF) discharges in different gases are studied using an improved multichannel system of electron-optical plasma photography and a newly elaborated synchronization system. The PCS structure in discharges in heavy gases (Ne, Ar) is found to differ significantly from that in discharges in hydrogen and deuterium. The influence of a heavy gas (Xe) additive to hydrogen and deuterium on the structure and compression dynamics of the PCS is investigated.

Flood monitoring network in southeastern Louisiana

USGS Publications Warehouse

McCallum, Brian E.

1994-01-01

A flood monitoring network has been established to alert emergency operations personnel and the public about hydrologic conditions in the Amite River Basin. The U.S. Geological Survey (USGS), in cooperation with the Louisiana Office of Emergency Preparedness (LOEP), has installed a real-time data acquisition system to monitor rainfall and river stages in the basin. These data will be transmitted for use by emergency operations personnel to develop flood control and evacuation strategies. The current river stages at selected gaging stations in the basin also will be broadcast by local television and radio stations during a flood. Residents can record the changing river stages on a basin monitoring map, similar to a hurricane tracking map.

Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments

PubMed Central

Trojan, Jörg; Zangos, Stephan; Schnitzbauer, Andreas A.

2016-01-01

Background Hepatocellular carcinoma (HCC) is a frequent complication of liver cirrhosis. Worldwide, HCC is one of the most common cancers, with a rising incidence. Methods A selective literature search was conducted, taking into account current studies, reviews, meta-analyses, and guidelines. Results The diagnosis is established either non-invasively by dynamic imaging, showing a typical contrast enhancement and wash-out, or histopathologically. Pathological diagnosis of HCC is recommended for all atypical nodules in patients with cirrhosis and for those in non-cirrhotic patients. Tumor therapy as well as treatment of the underlying chronic liver disease and/or preservation of liver function are important for the management of patients with HCC. Standard stage-adapted treatments are based on the widely applied Barcelona Clinic Liver Cancer staging system including liver resection and transplantation, interventional treatments such as thermal ablation and transarterial therapies, and systemic treatment with the tyrosine kinase inhibitor sorafenib. After failure of sorafenib, anti-angiogenic drugs, MET inhibitors, and immunotherapeutics are currently under advanced clinical investigation. Conclusion Treatment of HCC is multidisciplinary and therefore requires a close cooperation between various disciplines such as hepatology, visceral surgery, radiology, and oncology to achieve the best outcome depending on the tumor stage and degree of liver function impairment. PMID:27413729

A 10 Kelvin 3 Tesla Magnet for Space Flight ADR Systems

NASA Technical Reports Server (NTRS)

Tuttle, Jim; Shirron, Peter; Canavan, Edgar; DiPirro, Michael; Riall, Sara; Pourrahimi, Shahin

2003-01-01

Many future space flight missions are expected to use adiabatic demagnetization refrigerators (ADRs) to reach detector operating temperatures well below one Kelvin. The goal is to operate each ADR with a mechanical cooler as its heat sink, thus avoiding the use of liquid cryogens. Although mechanical coolers are being developed to operate at temperatures of 6 Kelvin and below, there is a large efficiency cost associated with operating them at the bottom of their temperature range. For the multi-stage ADR system being developed at Goddard Space Flight Center, the goal is to operate with a 10 Kelvin mechanical cooler heat sink. With currently available paramagnetic materials, the highest temperature ADR stage in such a system will require a magnetic field of approximately three Tesla. Thus the goal is to develop a small, lightweight three Tesla superconducting magnet for operation at 10 Kelvin. It is important that this magnet have a low current/field ratio. Because traditional NbTi magnets do not operate safely above about six Kelvin, a magnet with a higher Tc is required. The primary focus has been on Nb3Sn magnets. Since standard Nb3Sn wire must be coated with thick insulation, wound on a magnet mandrel and then reacted, standard Nb,Sn magnets are quite heavy and require high currents Superconducting Systems developed a Nb3Sn wire which can be drawn down to small diameter, reacted, coated with thin insulation and then wound on a small diameter coil form. By using this smaller wire and operating closer to the wire s critical current, it should be possible to reduce the mass and operating current of 10 Kelvin magnets. Using this "react-then-wind" technology, Superconducting Systems has produced prototype 10 Kelvin magnets. This paper describes the development and testing of these magnets and discusses the outlook for including 10 Kelvin magnets on space-flight missions.

A Pulsed Power System Design Using Lithium-ion Batteries and One Charger per Battery

DTIC Science & Technology

2009-12-01

zinc-bromine and vanadium redox batteries • NAS: high-temperature sodium batteries • EDLC: Electric Double-Layer Capacitors • SMES...terminology used in this figure. • Conventional: lead-acid, nickel-cadmium, and nickel-metal hydride batteries . • Lithium: lithium ion batteries . • Flow ...than the second stage due to less current flowing to the battery [5], [7], [8], [9]. Figure 4 shows typical current, voltage, and capacity curves

Design and Processing of Electret Structures

DTIC Science & Technology

2009-10-31

and width as a function of time. ( d ) Estimated current density j of dissolving copper disk as a function of time. (e) Total current I of dissolving...effect leading to a higher corrosion rate in the galvanic microreactor . Because of the small scale of our galvanic system, the dissolving copper disk is...estimated by focusing with a calibrated microscope stage.   Figure 5: Particle separation and electrolyte convection. Scale bars in ( A , D ) are 100 µm

High speed preamplifier circuit, detection electronics, and radiation detection systems therefrom

DOEpatents

Riedel, Richard A [Knoxville, TN; Wintenberg, Alan L [Knoxville, TN; Clonts, Lloyd G [Knoxville, TN; Cooper, Ronald G [Oak Ridge, TN

2010-09-21

A preamplifier circuit for processing a signal provided by a radiation detector includes a transimpedance amplifier coupled to receive a current signal from a detector and generate a voltage signal at its output. A second amplification stage has an input coupled to an output of the transimpedance amplifier for providing an amplified voltage signal. Detector electronics include a preamplifier circuit having a first and second transimpedance amplifier coupled to receive a current signal from a first and second location on a detector, respectively, and generate a first and second voltage signal at respective outputs. A second amplification stage has an input coupled to an output of the transimpedance amplifiers for amplifying the first and said second voltage signals to provide first and second amplified voltage signals. A differential output stage is coupled to the second amplification stage for receiving the first and second amplified voltage signals and providing a pair of outputs from each of the first and second amplified voltage signals. Read out circuitry has an input coupled to receive both of the pair of outputs, the read out circuitry having structure for processing each of the pair of outputs, and providing a single digital output having a time-stamp therefrom.

Water Resources Data for Illinois - Water Year 2005 (Includes Historical Data)

USGS Publications Warehouse

LaTour, J.K.; Weldon, E.A.; Dupre, D.H.; Halfar, T.M.

2006-01-01

This annual Water-Data Report for Illinois contains current water year (Oct. 1, 2004, to Sept. 30, 2005) and historical data of discharge, stage, water quality and biology of streams; stage of lakes and reservoirs; levels and quality of ground water; and records of precipitation, air temperature, dew point, solar radiation, and wind speed. The current year's (2005) data provided in this report include (1) discharge for 182 surface-water gaging stations and for 9 crest-stage partial-record stations; (2) stage for 33 surface-water gaging stations; (3) water-quality records for 10 surface-water stations; (4) sediment-discharge records for 14 surface-water stations; (5) water-level records for 98 ground-water wells; (6) water-quality records for 17 ground-water wells; (7) precipitation records for 48 rain gages; (8) records of air temperature, dew point, solar radiation and wind speed for 1 meteorological station; and (9) biological records for 6 sample sites. Also included are miscellaneous data collected at various sites not in the systematic data-collection network. Data were collected and compiled as a part of the National Water Information System (NWIS) maintained by the U.S. Geological Survey in cooperation with Federal, State, and local agencies.

Radiation detection system

DOEpatents

Riedel, Richard A [Knoxville, TN; Wintenberg, Alan L [Knoxville, TN; Clonts, Lloyd G [Knoxville, TN; Cooper, Ronald G [Oak Ridge, TN

2012-02-14

A preamplifier circuit for processing a signal provided by a radiation detector includes a transimpedance amplifier coupled to receive a current signal from a detector and generate a voltage signal at its output. A second amplification stage has an input coupled to an output of the transimpedance amplifier for providing an amplified voltage signal. Detector electronics include a preamplifier circuit having a first and second transimpedance amplifier coupled to receive a current signal from a first and second location on a detector, respectively, and generate a first and second voltage signal at respective outputs. A second amplification stage has an input coupled to an output of the transimpedance amplifiers for amplifying the first and said second voltage signals to provide first and second amplified voltage signals. A differential output stage is coupled to the second amplification stage for receiving the first and second amplified voltage signals and providing a pair of outputs from each of the first and second amplified voltage signals. Read out circuitry has an input coupled to receive both of the pair of outputs, the read out circuitry having structure for processing each of the pair of outputs, and providing a single digital output having a time-stamp therefrom.

Predicting Effects of Water Regime Changes on Waterbirds: Insights from Staging Swans

PubMed Central

Nolet, Bart A.; Gyimesi, Abel; van Krimpen, Roderick R. D.; de Boer, Willem F.; Stillman, Richard A.

2016-01-01

Predicting the environmental impact of a proposed development is notoriously difficult, especially when future conditions fall outside the current range of conditions. Individual-based approaches have been developed and applied to predict the impact of environmental changes on wintering and staging coastal bird populations. How many birds make use of staging sites is mostly determined by food availability and accessibility, which in the case of many waterbirds in turn is affected by water level. Many water systems are regulated and water levels are maintained at target levels, set by management authorities. We used an individual-based modelling framework (MORPH) to analyse how different target water levels affect the number of migratory Bewick’s swans Cygnus columbianus bewickii staging at a shallow freshwater lake (Lauwersmeer, the Netherlands) in autumn. As an emerging property of the model, we found strong non-linear responses of swan usage to changes in water level, with a sudden drop in peak numbers as well as bird-days with a 0.20 m rise above the current target water level. Such strong non-linear responses are probably common and should be taken into account in environmental impact assessments. PMID:26862895

Predicting Effects of Water Regime Changes on Waterbirds: Insights from Staging Swans.

PubMed

Nolet, Bart A; Gyimesi, Abel; van Krimpen, Roderick R D; de Boer, Willem F; Stillman, Richard A

2016-01-01

Predicting the environmental impact of a proposed development is notoriously difficult, especially when future conditions fall outside the current range of conditions. Individual-based approaches have been developed and applied to predict the impact of environmental changes on wintering and staging coastal bird populations. How many birds make use of staging sites is mostly determined by food availability and accessibility, which in the case of many waterbirds in turn is affected by water level. Many water systems are regulated and water levels are maintained at target levels, set by management authorities. We used an individual-based modelling framework (MORPH) to analyse how different target water levels affect the number of migratory Bewick's swans Cygnus columbianus bewickii staging at a shallow freshwater lake (Lauwersmeer, the Netherlands) in autumn. As an emerging property of the model, we found strong non-linear responses of swan usage to changes in water level, with a sudden drop in peak numbers as well as bird-days with a 0.20 m rise above the current target water level. Such strong non-linear responses are probably common and should be taken into account in environmental impact assessments.

All-optical photoacoustic imaging and detection of early-stage dental caries

NASA Astrophysics Data System (ADS)

Sampathkumar, Ashwin; Hughes, David A.; Longbottom, Chris; Kirk, Katherine J.

2015-02-01

Dental caries remain one of the most common oral diseases in the world. Current detection methods, such as dental explorer and X-ray radiography, suffer from poor sensitivity and specificity at the earliest (and reversible) stages of the disease because of the small size (< 100 microns) of early-stage lesions. We have developed a fine-resolution (480 nm), ultra-broadband (1 GHz), all-optical photoacoustic imaging (AOPAI) system to image and detect early stages of tooth decay. This AOPAI system provides a non-contact, non-invasive and non-ionizing means of detecting early-stage dental caries. Ex-vivo teeth exhibiting early-stage, white-spot lesions were imaged using AOPAI. Experimental scans targeted each early-stage lesion and a reference healthy enamel region. Photoacoustic (PA) signals were generated in the tooth using a 532-nm pulsed laser and the light-induced broadband ultrasound signal was detected at the surface of the tooth with an optical path-stabilized Michelson interferometer operating at 532 nm. The measured time-domain signal was spatially resolved and back-projected to form 2D and 3D maps of the lesion using k-wave reconstruction methods. Experimental data collected from areas of healthy and diseased enamel indicate that the lesion generated a larger PA response compared to healthy enamel. The PA-signal amplitude alone was able to detect a lesion on the surface of the tooth. However, time- reversal reconstructions of the PA scans also quantitatively depicted the depth of the lesion. 3D PA reconstruction of the diseased tooth indicated a sub-surface lesion at a depth of 0.6 mm, in addition to the surface lesion. These results suggest that our AOPAI system is well suited for rapid clinical assessment of early-stage dental caries. An overview of the AOPAI system, fine-resolution PA and histology results of diseased and healthy teeth will be presented.

Flood-inundation maps for the East Fork White River at Columbus, Indiana

USGS Publications Warehouse

Lombard, Pamela J.

2013-01-01

Digital flood-inundation maps for a 5.4-mile reach of the East Fork White River at Columbus, Indiana, from where the Flatrock and Driftwood Rivers combine to make up East Fork White River to just upstream of the confluence of Clifty Creek with the East Fork White River, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at USGS streamgage 03364000, East Fork White River at Columbus, Indiana. Current conditions at the USGS streamgage may be obtained on the Internet from the USGS National Water Information System (http://waterdata.usgs.gov/in/nwis/uv/?site_no=03364000&agency_cd=USGS&). The National Weather Service (NWS) forecasts flood hydrographs for the East Fork White River at Columbus, Indiana at their Advanced Hydrologic Prediction Service (AHPS) flood warning system Website (http://water.weather.gov/ahps/), that may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relation at USGS streamgage 03364000, East Fork White River at Columbus, Indiana. The calibrated hydraulic model was then used to determine 15 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from Light Detection and Ranging (LiDAR) data), having a 0.37-ft vertical accuracy and a 1.02 ft horizontal accuracy), in order to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage at Columbus, Indiana, and forecasted stream stages from the NWS will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post-flood recovery efforts.

Overview of NASA's Integrated Design and Engineering Analysis (IDEA)Environment

NASA Technical Reports Server (NTRS)

Robinson, Jeffrey S.; Martin John G.

2008-01-01

Historically, the design of subsonic and supersonic aircraft has been divided into separate technical disciplines (such as propulsion, aerodynamics and structures) each of which performs their design and analysis in relative isolation from others. This is possible in most cases either because the amount of interdisciplinary coupling is minimal or because the interactions can be treated as linear. The design of hypersonic airbreathing vehicles, like NASA s X-43, is quite the opposite. Such systems are dominated by strong non-linear interactions between disciplines. The design of these systems demands that a multi-disciplinary approach be taken. Furthermore, increased analytical fidelity at the conceptual design phase is highly desirable as many of the non-linearities are not captured by lower fidelity tools. Only when these systems are designed from a true multi-disciplinary perspective can the real performance benefits be achieved and complete vehicle systems be fielded. Toward this end, the Vehicle Analysis Branch at NASA Langley Research Center has been developing the Integrated Design & Engineering Analysis (IDEA) Environment. IDEA is a collaborative environment for parametrically modeling conceptual and preliminary launch vehicle configurations using the Adaptive Modeling Language (AML) as the underlying framework. The environment integrates geometry, configuration, propulsion, aerodynamics, aerothermodynamics, trajectory, closure and structural analysis into a generative, parametric, unified computational model where data is shared seamlessly between the different disciplines. Plans are also in place to incorporate life cycle analysis tools into the environment which will estimate vehicle operability, reliability and cost. IDEA is currently being funded by NASA s Hypersonics Project, a part of the Fundamental Aeronautics Program within the Aeronautics Research Mission Directorate. The environment is currently focused around a two-stage-to-orbit configuration with a turbine based combined cycle (TBCC) first stage and reusable rocket second stage. This paper provides an overview of the development of the IDEA environment, a description of the current status and detail of future plans.

NASA Propulsion Sub-System Concept Studies and Risk Reduction Activities for Resource Prospector Lander

NASA Technical Reports Server (NTRS)

Trinh, Huu P.

2015-01-01

NASA's exploration roadmap is focused on developing technologies and performing precursor missions to advance the state of the art for eventual human missions to Mars. One of the key components of this roadmap is various robotic missions to Near-Earth Objects, the Moon, and Mars to fill in some of the strategic knowledge gaps. The Resource Prospector (RP) project is one of these robotic precursor activities in the roadmap. RP is a multi-center and multi-institution project to investigate the polar regions of the Moon in search of volatiles. The mission is rated Class D and is approximately 10 days, assuming a five day direct Earth to Moon transfer. Because of the mission cost constraint, a trade study of the propulsion concepts was conducted with a focus on available low-cost hardware for reducing cost in development, while technical risk, system mass, and technology advancement requirements were also taken into consideration. The propulsion system for the lander is composed of a braking stage providing a high thrust to match the lander's velocity with the lunar surface and a lander stage performing the final lunar descent. For the braking stage, liquid oxygen (LOX) and liquid methane (LCH4) propulsion systems, derived from the Morpheus experimental lander, and storable bi-propellant systems, including the 4th stage Peacekeeper (PK) propulsion components and Space Shuttle orbital maneuvering engine (OME), and a solid motor were considered for the study. For the lander stage, the trade study included miniaturized Divert Attitude Control System (DACS) thrusters (Missile Defense Agency (MDA) heritage), their enhanced thruster versions, ISE-100 and ISE-5, and commercial-off-the-shelf (COTS) hardware. The lowest cost configuration of using the solid motor and the PK components while meeting the requirements was selected. The reference concept of the lander is shown in Figure 1. In the current reference configuration, the solid stage is the primary provider of delta-V. It will generate 15,000-lbf of thrust with a single burn of 80's seconds. The lander stage is a bi-propellant, pressure-regulated, pulsing liquid propulsion system to perform all other functions.

A Role of Base Plate Jerk Feedback Scheme for Suppression of the Self Vibration in a Pneumatic Positioning Stage

NASA Astrophysics Data System (ADS)

Wali, Mohebullah; Nakamura, Yukinori; Wakui, Shinji

In this study, a positioning stage is considered, which is actuated by four pneumatic cylinders and vertically supported by four coil-type spring isolators. Previously, we realized the base plate jerk feedback (BPJFB) to be analogues to a Master-Slave system which can synchronize the motion of the stage as a Slave to the motion of the base plate as a Master. However, in the case of real positioning, the stage had slightly self oscillation with higher frequency due to the higher gains set to the outer feedback loop controller besides its oscillation due to the natural vibration of the base plate. The self oscillation of stage was misunderstood to be the natural vibration of base plate due to the reaction force. However, according to the experimental results, the BPJFB scheme was able to control both of the mentioned vibrations. Suppression of the self vibration of stage is an interesting phenomenon, which should be experimentally investigated. Therefore, the current study focuses on the suppression of the self vibration of stage by using the BPJFB scheme. The experimental results show that besides operating as a Master-Slave synchronizing system, the PBJFB scheme is able to increase the damping ratio and stiffness of stage against its self vibration. This newly recognized phenomenon contributes to further increase the proportional gain of the outer feedback loop controller. As a result, the positioning speed and stability can be improved.

Selection System for the "Stay-green" Drought Tolerance Trait in Sorghum Germplasm

USDA-ARS?s Scientific Manuscript database

Post-flowering drought tolerance is an essential trait for increasing cereal production in Mediterranean climates. Current methodologies for identifying the nonsenescent (stay-green) trait require the right intensity of drought stress at the right developmental stage to visually evaluate lines in t...

Ten Years of Entrepreneurship Education at Chinese Universities: Evolution, Problems, and System Building

ERIC Educational Resources Information Center

Weiming, Li; Chunyan, Li; Xiaohua, Du

2016-01-01

Entrepreneurship education has experienced four stages of development in Chinese universities, shifting from entrepreneurship show to entrepreneurship education, from teacher training to student education, from classroom teaching to multimodal teaching, and from imparting knowledge to cultivating skills. Currently, the weak links in…

Designing flexible engineering systems utilizing embedded architecture options

NASA Astrophysics Data System (ADS)

Pierce, Jeff G.

This dissertation develops and applies an integrated framework for embedding flexibility in an engineered system architecture. Systems are constantly faced with unpredictability in the operational environment, threats from competing systems, obsolescence of technology, and general uncertainty in future system demands. Current systems engineering and risk management practices have focused almost exclusively on mitigating or preventing the negative consequences of uncertainty. This research recognizes that high uncertainty also presents an opportunity to design systems that can flexibly respond to changing requirements and capture additional value throughout the design life. There does not exist however a formalized approach to designing appropriately flexible systems. This research develops a three stage integrated flexibility framework based on the concept of architecture options embedded in the system design. Stage One defines an eight step systems engineering process to identify candidate architecture options. This process encapsulates the operational uncertainty though scenario development, traces new functional requirements to the affected design variables, and clusters the variables most sensitive to change. The resulting clusters can generate insight into the most promising regions in the architecture to embed flexibility in the form of architecture options. Stage Two develops a quantitative option valuation technique, grounded in real options theory, which is able to value embedded architecture options that exhibit variable expiration behavior. Stage Three proposes a portfolio optimization algorithm, for both discrete and continuous options, to select the optimal subset of architecture options, subject to budget and risk constraints. Finally, the feasibility, extensibility and limitations of the framework are assessed by its application to a reconnaissance satellite system development problem. Detailed technical data, performance models, and cost estimates were compiled for the Tactical Imaging Constellation Architecture Study and leveraged to complete a realistic proof-of-concept.

Multiparametric prostate MRI: technical conduct, standardized report and clinical use.

PubMed

Manfredi, Matteo; Mele, Fabrizio; Garrou, Diletta; Walz, Jochen; Fütterer, Jurgen J; Russo, Filippo; Vassallo, Lorenzo; Villers, Arnauld; Emberton, Mark; Valerio, Massimo

2018-02-01

Multiparametric prostate MRI (mp-MRI) is an emerging imaging modality for diagnosis, characterization, staging, and treatment planning of prostate cancer (PCa). The technique, results reporting, and its role in clinical practice have been the subject of significant development over the last decade. Although mp-MRI is not yet routinely used in the diagnostic pathway, almost all urological guidelines have emphasized the potential role of mp-MRI in several aspects of PCa management. Moreover, new MRI sequences and scanning techniques are currently under evaluation to improve the diagnostic accuracy of mp-MRI. This review presents an overview of mp-MRI, summarizing the technical applications, the standardized reporting systems used, and their current roles in various stages of PCa management. Finally, this critical review also reports the main limitations and future perspectives of the technique.

Discovery of urine biomarkers for bladder cancer via global metabolomics.

PubMed

Shi, Hangchuan; Li, Xiang; Zhang, Qingyang; Yang, Hongmei; Zhang, Xiaoping

2016-11-01

Bladder cancer (BC) is latent in its early stage and lethal in its late stage. Therefore, early diagnosis and intervention are essential for successful BC treatment. Considering the limitations of current diagnostic tools, noninvasive biomarkers that are both highly sensitive and specific are needed to improve the overall survival and quality of life of patients. With the advent of systems biology, "-omics" technologies have been developed over the past few decades. As a promising member, global metabolomics has increasingly been found to have clear potential for biomarker discovery. However, urinary metabolomics studies related to BC have lagged behind those of other urinary cancers, and major findings have not been systematically reported. The objective of this review is to comprehensively list the currently identified potential urinary metabolite biomarkers for BC.

Frequent hemodialysis in children.

PubMed

Warady, Bradley A; Fischbach, Michel; Geary, Denis; Goldstein, Stuart L

2007-07-01

Frequent hemodialysis is currently conducted in a limited number of pediatric dialysis centers. However, the preliminary experience with children who have undergone procedures such as "daily" intensive hemodiafiltration and nocturnal hemodialysis has been positive, with the allowance for unrestricted diets and fluid intake, the lack of need for phosphate binders, excellent metabolic and blood pressure control, and, in the case of hemodiafiltration, excellent growth. The provision of frequent daily hemodialysis with the NxStage System has also recently been introduced to pediatrics. An overview about what is currently understood regarding the technical and clinical application of these approaches to therapy for children with end-stage renal disease form the basis for this article and highlight the impact of the procedures to date and the need for additional experience and collaborative data collection.

Electromagnetic-gravitational energy systems

NASA Technical Reports Server (NTRS)

Schatten, K. H.

1981-01-01

Two methods are considered to 'tap' the earth's rotational energy. This ancient 'collapsed gravitational energy' exceeds the earth-lunar binding energy. One involves an orbiting 'electromagnetic-gravitational' coupling system whereby the earth's rotation, with its nonuniform mass distribution, first uses gravity to add orbital energy to a satellite, similar to a planetary 'flyby'. The second stage involves enhanced satellite 'drag' as current-carrying coils withdraw the added orbital energy as they pass through the earth's nonuniform magnetic field. A second more direct method couples the earth's rotational motion using conducting wires moving through the noncorotating part (ionospheric current systems) of the geomagnetic field. These methods, although not immediately feasible, are considerably more efficient than using pure gravitational coupling to earth-moon tides.

Modeling and simulation of a direct ethanol fuel cell: An overview

NASA Astrophysics Data System (ADS)

Abdullah, S.; Kamarudin, S. K.; Hasran, U. A.; Masdar, M. S.; Daud, W. R. W.

2014-09-01

The commercialization of Direct Ethanol Fuel Cells (DEFCs) is still hindered because of economic and technical reasons. Fundamental scientific research is required to more completely understanding the complex electrochemical behavior and engineering technology of DEFCs. To use the DEFC system in real-world applications, fast, reliable, and cost-effective methods are needed to explore this complex phenomenon and to predict the performance of different system designs. Thus, modeling and simulation play an important role in examining the DEFC system as well as in designing an optimized DEFC system. The current DEFC literature shows that modeling studies on DEFCs are still in their early stages and are not able to describe the DEFC system as a whole. Potential DEFC applications and their current status are also presented.

A CMOS enhanced solid-state nanopore based single molecule detection platform.

PubMed

Chen, Chinhsuan; Yemenicioglu, Sukru; Uddin, Ashfaque; Corgliano, Ellie; Theogarajan, Luke

2013-01-01

Solid-state nanopores have emerged as a single molecule label-free electronic detection platform. Existing transimpedance stages used to measure ionic current nanopores suffer from dynamic range limitations resulting from steady-state baseline currents. We propose a digitally-assisted baseline cancellation CMOS platform that circumvents this issue. Since baseline cancellation is a form of auto-zeroing, the 1/f noise of the system is also reduced. Our proposed design can tolerate a steady state baseline current of 10µA and has a usable bandwidth of 750kHz. Quantitative DNA translocation experiments on 5kbp DNA was performed using a 5nm silicon nitride pore using both the CMOS platform and a commercial system. Comparison of event-count histograms show that the CMOS platform clearly outperforms the commercial system, allowing for unambiguous interpretation of the data.

Flood-inundation maps for the West Branch Susquehanna River near the Boroughs of Lewisburg and Milton, Pennsylvania

USGS Publications Warehouse

Roland, Mark A.; Hoffman, Scott A.

2014-01-01

Digital flood-inundation maps for an approximate 8-mile reach of the West Branch Susquehanna River from approximately 2 miles downstream from the Borough of Lewisburg, extending upstream to approximately 1 mile upstream from the Borough of Milton, Pennsylvania, were created by the U.S. Geological Survey (USGS) in cooperation with the Susquehanna River Basin Commission (SRBC). The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict the estimated areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 01553500, West Branch Susquehanna River at Lewisburg, Pa. In addition, the information has been provided to the Susquehanna River Basin Commission (SRBC) for incorporation into their Susquehanna Inundation Map Viewer (SIMV) flood warning system (http://maps.srbc.net/simv/). The National Weather Service (NWS) forecasted peak-stage information (http://water.weather.gov/ahps) for USGS streamgage 01553500, West Branch Susquehanna River at Lewisburg, Pa., may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. Calibration of the model was achieved using the most current stage-discharge relations (rating number 11.1) at USGS streamgage 01553500, West Branch Susquehanna River at Lewisburg, Pa., a documented water-surface profile from the December 2, 2010, flood, and recorded peak stage data. The hydraulic model was then used to determine 26 water-surface profiles for flood stages at 1-foot intervals referenced to the streamgage datum ranging from 14 feet (ft) to 39 ft. Modeled flood stages, as defined by NWS, include Action Stage, 14 ft; Flood Stage, 18 ft; Moderate Flood Stage, 23 ft; and Major Flood Stage, 28 ft. Geographic information system (GIS) technology was then used to combine the simulated water-surface profiles with a digital elevation model (DEM) derived from light detection and ranging (lidar) data to delineate the area flooded at each water level. The availability of these maps, along with World Wide Web information regarding current stage from USGS streamgages and forecasted stream stages from the NWS, provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

Treating rheumatic diseases in pregnancy: dos and don'ts

PubMed Central

Lockshin, M D

2006-01-01

This paper presents a critical appraisal of the current evidence and recommendations regarding the use of pharmaceuticals and biologicals in pregnancy. Clinical experience is often at variance with published recommendations as studies have not taken into account the differences in physiology in the various stages of gestation and between animal and human pregnancies. Physicians should bear in mind that pregnancy causes disruption in several organ systems; the effects of an intervention may depend on the stage of gestation; and some effects of interventions in pregnancy may not manifest until adulthood. PMID:17038475

Treating rheumatic diseases in pregnancy: dos and don'ts.

PubMed

Lockshin, M D

2006-11-01

This paper presents a critical appraisal of the current evidence and recommendations regarding the use of pharmaceuticals and biologicals in pregnancy. Clinical experience is often at variance with published recommendations as studies have not taken into account the differences in physiology in the various stages of gestation and between animal and human pregnancies. Physicians should bear in mind that pregnancy causes disruption in several organ systems; the effects of an intervention may depend on the stage of gestation; and some effects of interventions in pregnancy may not manifest until adulthood.

Analysis for the Design of a U.S. Navy Diving and Salvage Smart Stage

DTIC Science & Technology

2013-06-01

to be salvaged or constructed in the depths of the water , they send in the U.S. Navy divers to carry out that task. The current device used to...conditions of the waters vary depending on the location and situation in which they are called upon to act. A dive stage is used when a diver is...used in tropical waters for one salvage job, and then the next time it is used may be in frigid arctic waters (Commander, Naval Sea Systems Command

Development of a breadboard design of a high-performance, high-reliability switching regulator

NASA Technical Reports Server (NTRS)

Lindena, S. J.

1975-01-01

A comparison of two potential conversion methods, the series inverter and the inductive energy transfer (IET) conversion technique, is presented. The investigations showed that a characteristic of the series inverter circuit (high equalizing current values in each half cycle) could not be accomplished with available components, and the investigations continued with the IET circuit only. An IET circuit system was built with the use of computer-aided design in a 2, 4, and 8 stage configuration, and these stages were staggered 180, 90, and 45 degrees, respectively. All stages were pulsewidth modulated to regulate over an input voltage range from 200 to 400 volts dc at a regulated output voltage of 56 volts. The output power capability was 100 to 500 watts for the 2 and 8 stage configuration and 50 to 250 watts for the 4 stage configuration. Equal control of up to eight 45 degree staggered stages was accomplished through the use of a digital-to-analog control circuit. Equal power sharing of all stages was achieved through a new technique using an inductively coupled balancing circuit. Conclusions are listed.

Control of malodorous hydrogen sulfide compounds using microbial fuel cell.

PubMed

Eaktasang, Numfon; Min, Hyeong-Sik; Kang, Christina; Kim, Han S

2013-10-01

In this study, a microbial fuel cell (MFC) was used to control malodorous hydrogen sulfide compounds generated from domestic wastewaters. The electricity production demonstrated a distinct pattern of a two-step increase during 170 h of system run: the first maximum current density was 118.6 ± 7.2 mA m⁻² followed by a rebound of current density increase, reaching the second maximum of 176.8 ± 9.4 mA m⁻². The behaviors of the redox potential and the sulfate level in the anode compartment indicated that the microbial production of hydrogen sulfide compounds was suppressed in the first stage, and the hydrogen sulfide compounds generated from the system were removed effectively as a result of their electrochemical oxidation, which contributed to the additional electricity production in the second stage. This was also directly supported by sulfur deposits formed on the anode surface, which was confirmed by analyses on those solids using a scanning electron microscope equipped with energy dispersive X-ray spectroscopy as well as an elemental analyzer. To this end, the overall reduction efficiencies for HS⁻ and H₂S(g) were as high as 67.5 and 96.4 %, respectively. The correlations among current density, redox potential, and sulfate level supported the idea that the electricity signal generated in the MFC can be utilized as a potential indicator of malodor control for the domestic wastewater system.

Fourier heat conduction as a strong kinetic effect in one-dimensional hard-core gases

NASA Astrophysics Data System (ADS)

Zhao, Hanqing; Wang, Wen-ge

2018-01-01

For a one-dimensional (1D) momentum conserving system, intensive studies have shown that generally its heat current autocorrelation function (HCAF) tends to decay in a power-law manner and results in the breakdown of the Fourier heat conduction law in the thermodynamic limit. This has been recognized to be a dominant hydrodynamic effect. Here we show that, instead, the kinetic effect can be dominant in some cases and leads to the Fourier law for finite-size systems. Usually the HCAF undergoes a fast decaying kinetic stage followed by a long slowly decaying hydrodynamic tail. In a finite range of the system size, we find that whether the system follows the Fourier law depends on whether the kinetic stage dominates. Our Rapid Communication is illustrated by the 1D hard-core gas models with which the HCAF is derived analytically and verified numerically by molecular dynamics simulations.

Scanning Electron Microscope Mapping System Developed for Detecting Surface Defects in Fatigue Specimens

NASA Technical Reports Server (NTRS)

Bonacuse, Peter J.; Kantzos, Peter T.

2002-01-01

An automated two-degree-of-freedom specimen positioning stage has been developed at the NASA Glenn Research Center to map and monitor defects in fatigue specimens. This system expedites the examination of the entire gauge section of fatigue specimens so that defects can be found using scanning electron microscopy (SEM). Translation and rotation stages are driven by microprocessor-based controllers that are, in turn, interfaced to a computer running custom-designed software. This system is currently being used to find and record the location of ceramic inclusions in powder metallurgy materials. The mapped inclusions are periodically examined during interrupted fatigue experiments. The number of cycles to initiate cracks from these inclusions and the rate of growth of initiated cracks can then be quantified. This information is necessary to quantify the effect of this type of defect on the durability of powder metallurgy materials. This system was developed with support of the Ultra Safe program.

Current limiting remote power control module

NASA Technical Reports Server (NTRS)

Hopkins, Douglas C.

1990-01-01

The power source for the Space Station Freedom will be fully utilized nearly all of the time. As such, any loads on the system will need to operate within expected limits. Should any load draw an inordinate amount of power, the bus voltage for the system may sag and disrupt the operation of other loads. To protect the bus and loads some type of power interface between the bus and each load must be provided. This interface is most crucial when load faults occur. A possible system configuration is presented. The proposed interface is the Current Limiting Remote Power Controller (CL-RPC). Such an interface should provide the following power functions: limit overloading and resulting undervoltage; prevent catastrophic failure and still provide for redundancy management within the load; minimize cable heating; and provide accurate current measurement. A functional block diagram of the power processing stage of a CL-RPC is included. There are four functions that drive the circuit design: rate control of current; current sensing; the variable conductance switch (VCS) technology; and the algorithm used for current limiting. Each function is discussed separately.

Late Pleistocene sequence architecture on the geostrophic current-dominated southwest margin of the Ulleung Basin, East Sea

NASA Astrophysics Data System (ADS)

Choi, Dong-Lim; Shin, Dong-Hyeok; Kum, Byung-Cheol; Jang, Seok; Cho, Jin-Hyung; Jou, Hyeong-Tae; Jang, Nam-Do

2018-06-01

High-resolution multichannel seismic data were collected to identify depositional sequences on the southwestern shelf of the Ulleung Basin, where a unidirectional ocean current is dominant at water depths exceeding 130 m. Four aggradational stratigraphic sequences with a 100,000-year cycle were recognized since marine isotope stage (MIS) 10. These sequences consist only of lowstand systems tracts (LSTs) and falling-stage systems tracts (FSSTs). Prograding wedge-shaped deposits are present in the LSTs near the shelf break. Oblique progradational clinoforms of forced regressive deposits are present in the FSSTs on the outer continental shelf. Each FSST has non-uniform forced regressional stratal geometries, reflecting that the origins of sediments in each depositional sequence changed when sea level was falling. Slump deposits are characteristically developed in the upper layer of the FSSTs, and this was used as evidence to distinguish the sequence boundaries. The subsidence rates around the shelf break reached as much as 0.6 mm/year since MIS 10, which contributed to the well-preserved depositional sequence. During the Quaternary sea-level change, the water depth in the Korea Strait declined and the intensity of the Tsushima Current flowing near the bottom of the inner continental shelf increased. This resulted in greater erosion of sediments that were delivered to the outer continental shelf, which was the main cause of sediment deposition on the deep, low-angled outer shelf. Therefore, a depositional sequence formation model that consists of only FSSTs and LSTs, excluding highstand systems tracts (HSTs) and transgressive systems tracts (TSTs), best explains the depositional sequence beneath this shelf margin dominated by a geostrophic current.

Late Pleistocene sequence architecture on the geostrophic current-dominated southwest margin of the Ulleung Basin, East Sea

NASA Astrophysics Data System (ADS)

Choi, Dong-Lim; Shin, Dong-Hyeok; Kum, Byung-Cheol; Jang, Seok; Cho, Jin-Hyung; Jou, Hyeong-Tae; Jang, Nam-Do

2017-11-01

High-resolution multichannel seismic data were collected to identify depositional sequences on the southwestern shelf of the Ulleung Basin, where a unidirectional ocean current is dominant at water depths exceeding 130 m. Four aggradational stratigraphic sequences with a 100,000-year cycle were recognized since marine isotope stage (MIS) 10. These sequences consist only of lowstand systems tracts (LSTs) and falling-stage systems tracts (FSSTs). Prograding wedge-shaped deposits are present in the LSTs near the shelf break. Oblique progradational clinoforms of forced regressive deposits are present in the FSSTs on the outer continental shelf. Each FSST has non-uniform forced regressional stratal geometries, reflecting that the origins of sediments in each depositional sequence changed when sea level was falling. Slump deposits are characteristically developed in the upper layer of the FSSTs, and this was used as evidence to distinguish the sequence boundaries. The subsidence rates around the shelf break reached as much as 0.6 mm/year since MIS 10, which contributed to the well-preserved depositional sequence. During the Quaternary sea-level change, the water depth in the Korea Strait declined and the intensity of the Tsushima Current flowing near the bottom of the inner continental shelf increased. This resulted in greater erosion of sediments that were delivered to the outer continental shelf, which was the main cause of sediment deposition on the deep, low-angled outer shelf. Therefore, a depositional sequence formation model that consists of only FSSTs and LSTs, excluding highstand systems tracts (HSTs) and transgressive systems tracts (TSTs), best explains the depositional sequence beneath this shelf margin dominated by a geostrophic current.

Nuclear Engine System Simulation (NESS). Volume 1: Program user's guide

NASA Astrophysics Data System (ADS)

Pelaccio, Dennis G.; Scheil, Christine M.; Petrosky, Lyman J.

1993-03-01

A Nuclear Thermal Propulsion (NTP) engine system design analysis tool is required to support current and future Space Exploration Initiative (SEI) propulsion and vehicle design studies. Currently available NTP engine design models are those developed during the NERVA program in the 1960's and early 1970's and are highly unique to that design or are modifications of current liquid propulsion system design models. To date, NTP engine-based liquid design models lack integrated design of key NTP engine design features in the areas of reactor, shielding, multi-propellant capability, and multi-redundant pump feed fuel systems. Additionally, since the SEI effort is in the initial development stage, a robust, verified NTP analysis design tool could be of great use to the community. This effort developed an NTP engine system design analysis program (tool), known as the Nuclear Engine System Simulation (NESS) program, to support ongoing and future engine system and stage design study efforts. In this effort, Science Applications International Corporation's (SAIC) NTP version of the Expanded Liquid Engine Simulation (ELES) program was modified extensively to include Westinghouse Electric Corporation's near-term solid-core reactor design model. The ELES program has extensive capability to conduct preliminary system design analysis of liquid rocket systems and vehicles. The program is modular in nature and is versatile in terms of modeling state-of-the-art component and system options as discussed. The Westinghouse reactor design model, which was integrated in the NESS program, is based on the near-term solid-core ENABLER NTP reactor design concept. This program is now capable of accurately modeling (characterizing) a complete near-term solid-core NTP engine system in great detail, for a number of design options, in an efficient manner. The following discussion summarizes the overall analysis methodology, key assumptions, and capabilities associated with the NESS presents an example problem, and compares the results to related NTP engine system designs. Initial installation instructions and program disks are in Volume 2 of the NESS Program User's Guide.

Nuclear Engine System Simulation (NESS). Volume 1: Program user's guide

NASA Technical Reports Server (NTRS)

Pelaccio, Dennis G.; Scheil, Christine M.; Petrosky, Lyman J.

1993-01-01

A Nuclear Thermal Propulsion (NTP) engine system design analysis tool is required to support current and future Space Exploration Initiative (SEI) propulsion and vehicle design studies. Currently available NTP engine design models are those developed during the NERVA program in the 1960's and early 1970's and are highly unique to that design or are modifications of current liquid propulsion system design models. To date, NTP engine-based liquid design models lack integrated design of key NTP engine design features in the areas of reactor, shielding, multi-propellant capability, and multi-redundant pump feed fuel systems. Additionally, since the SEI effort is in the initial development stage, a robust, verified NTP analysis design tool could be of great use to the community. This effort developed an NTP engine system design analysis program (tool), known as the Nuclear Engine System Simulation (NESS) program, to support ongoing and future engine system and stage design study efforts. In this effort, Science Applications International Corporation's (SAIC) NTP version of the Expanded Liquid Engine Simulation (ELES) program was modified extensively to include Westinghouse Electric Corporation's near-term solid-core reactor design model. The ELES program has extensive capability to conduct preliminary system design analysis of liquid rocket systems and vehicles. The program is modular in nature and is versatile in terms of modeling state-of-the-art component and system options as discussed. The Westinghouse reactor design model, which was integrated in the NESS program, is based on the near-term solid-core ENABLER NTP reactor design concept. This program is now capable of accurately modeling (characterizing) a complete near-term solid-core NTP engine system in great detail, for a number of design options, in an efficient manner. The following discussion summarizes the overall analysis methodology, key assumptions, and capabilities associated with the NESS presents an example problem, and compares the results to related NTP engine system designs. Initial installation instructions and program disks are in Volume 2 of the NESS Program User's Guide.

Phoenix: Quantum Quality at Maricopa: TQM on Campus, Case Study Number Two.

ERIC Educational Resources Information Center

Assar, Kathleen E.

1993-01-01

Implementation of the Total Quality Management approach in the Maricopa County Community College District (Arizona), a large 10-campus system, is described. The program's current early stages are reported noting the serious administrative commitment and thorough training, seen as key factors in potential success. (MSE)

Colorado geothermal commercialization program: community development of geothermal energy in Pagosa Springs, Colorado

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coe, B.A.

1980-01-01

A district heating system for the Pagosa Springs central business district is in the planning stage. A detailed analysis of the project is presented. It comprises area and site specific studies and describes in detail the recent, current, anticipated, and postulated geothermal development activities. (MHR)

Research Technology

NASA Image and Video Library

2004-04-15

Harnessing the Sun's energy through Solar Thermal Propulsion will propel vehicles through space by significantly reducing weight, complexity, and cost while boosting performance over current conventional upper stages. Another solar powered system, solar electric propulsion, demonstrates ion propulsion is suitable for long duration missions. Pictured is an artist's concept of space flight using solar thermal propulsion.

Prototype development and demonstration for response, emergency staging, communications, uniform management, and evacuation (R.E.S.C.U.M.E.) : information broker framework analysis.

DOT National Transportation Integrated Search

2015-03-01

Through the Dynamic Mobility Applications (DMA) Program, U.S. DOT desires to improve current operational practices and transform management of future surface transportation systems. The DMA program is designed to enhance deployment of emerging techno...

Polyphase enrichment and redistribution processes in silver-rich mineral associations of the hydrothermal fluorite-barite-(Ag-Cu) Clara deposit, SW Germany

NASA Astrophysics Data System (ADS)

Keim, Maximilian F.; Walter, Benjamin F.; Neumann, Udo; Kreissl, Stefan; Bayerl, Richard; Markl, Gregor

2018-03-01

The silver-copper sulfide mineralization associated with the fluorite-barite vein system at the Clara deposit in SW Germany shows large scale vertical zoning. Low to moderate silver contents prevail in the upper 350 m, whereas high silver contents occur in the subsequent 450 m of the currently known vein system. This change in Ag tenor is related to conspicuous mineralogical changes with depth. A detailed petrographic and fluid inclusion study identifies evidence for five subsequent hydrothermal and one alteration stage—all contributing to mineralogical diversity. The vertical Ag zoning, however, is attributed only to the first of these stages. During this first stage, increasing oxidation of ascending hydrothermal fluids (90-160 °C, 24.2-26.7 wt% NaCl+CaCl2) led to the formation of high-Ag tetrahedrite-tennantite in the lower parts and basically Ag-free enargite in the upper parts of the vein system. The subsequent hydrothermal stage led to significant mineralogical changes, but inherited the pre-existing Ag zonation. In this second hydrothermal stage, which was related to fluids similar in composition to those of the first stage (70-125 °C, 23.1-26.5 wt% NaCl+CaCl2), dissolution of high Ag-tetrahedrite-tennantite resulted in the formation of complex Ag-sulfosalts together with moderately Ag-bearing tetrahedrite-tennantite and chalcopyrite. The first two stages were formed by fluid mixing of a sedimentary and a hot basement fluid. The influx of fluids with high Ag, Bi and Pb activity during stage 3 and 5 resulted in the local replacement of earlier Ag-sulfosalts by galena and Ag-(Bi)-sulfosalts. The fourth stage is marked by partial dissolution of sulfides and sulfosalts by a late, hot, undiluted basement fluid (250 °C, 18.7-20.9 wt% NaCl+CaCl2) precipitating fluorite, barite and quartz. Finally, supergene alteration lead to the dissolution of silver-bearing phases and the precipitation of acanthite and native silver. The study illustrates, how metal tenor and mineralogy are decoupled in vertically extensive, polyphase hydrothermal vein systems. This may be pertinent to similarly zoned polymetallic vein systems.

Enabling and Enhancing Space Mission Success and Reduction of Risk through the Application of an Integrated Data Architecture

NASA Technical Reports Server (NTRS)

Brummett, Robert C.

2008-01-01

The engineering phases of design, development, test, and evaluation (DDT and E) and subsequent planning, preparation, and operation (Ops) of space vehicles in a complex and distributed environment requires massive and continuous flows of information across the enterprise and across temporal stages of the vehicle lifecycle. The resulting capabilities at each subsequent stage depend in part on the capture, preparation, storage, and subsequent provision of information from prior stages. The United States National Aeronautics and Space Administration (NASA) is currently designing a fleet of new vehicles that will replace the Space Shuttle and expand space operations and exploration capabilities. This includes the 2 stage human rated lift vehicle Ares 1 and its associated crew vehicle the Orion, and a service module; the heavy lift cargo vehicle, Ares 5, and an associated cargo stage known as the Earth Departure Stage; and a Lunar Lander vehicle that contains a descent stage, and ascent stage, and a habitation module. A variety of concurrent assorted ground operations infrastructure including software and facilities are also being developed, assorted technology and assembly designs and development for equipment such as EVA suits, life support systems, command and control technologies are also in the pipeline. The development is occurring in a distributed manner, with project deliverables being contributed by a large and diverse assortment of vendors and most space faring nations. Critical information about all of the components, software, and procedures must be shared during the DDT and E phases and then made readily available to the mission operations staff for access during the planning, preparation, and operations phases, and also need to be readily available for system to system interactions. The Constellation Data Systems Project (CxDS) is identifying the needs, and designing and deploying systems and processes to support these needs. This paper details the steps and processes that NASA is applying within the Constellation Program to manage this data and information, and to insure that the correct information is available, correctly annotated, and can be provisioned digitally to enhance response times, and support engineering analysis and anomaly resolution.

Simulator Study of Helmet-Mounted Symbology System Concepts in Degraded Visual Environments.

PubMed

Cheung, Bob; McKinley, Richard A; Steels, Brad; Sceviour, Robert; Cosman, Vaughn; Holst, Peter

2015-07-01

A sudden loss of external visual cues during critical phases of flight results in spatial disorientation. This is due to undetected horizontal and vertical drift when there is little tolerance for error and correction delay as the helicopter is close to the ground. Three helmet-mounted symbology system concepts were investigated in the simulator as potential solutions for the legacy Griffon helicopters. Thirteen Royal Canadian Air Force (RCAF) Griffon pilots were exposed to the Helmet Display Tracking System for Degraded Visual Environments (HDTS), the BrownOut Symbology System (BOSS), and the current RCAF AVS7 symbology system. For each symbology system, the pilot performed a two-stage departure and a single-stage approach. The presentation order of the symbology systems was randomized. Objective performance metrics included aircraft speed, altitude, attitude, and distance from the landing point. Subjective measurements included situation awareness, mental effort, perceived performance, perceptual cue rating, and NASA Task Load Index. Repeated measures analysis of variance and subsequent planned comparison for all the objective and subjective measurements were performed between the AVS7, HDTS, and BOSS. Our results demonstrated that HDTS and BOSS showed general improvement over AVS7 in two-stage departure. However, only HDTS performed significantly better in heading error than AVS7. During the single-stage approach, BOSS performed worse than AVS7 in heading root mean square error, and only HDTS performed significantly better in distance to landing point and approach heading than the others. Both the HDTS and BOSS possess their own limitations; however, HDTS is the pilots' preferred flight display.

Solid-state current transformer

NASA Technical Reports Server (NTRS)

Farnsworth, D. L. (Inventor)

1976-01-01

A signal transformation network which is uniquely characterized to exhibit a very low input impedance while maintaining a linear transfer characteristic when driven from a voltage source and when quiescently biased in the low microampere current range is described. In its simplest form, it consists of a tightly coupled two transistor network in which a common emitter input stage is interconnected directly with an emitter follower stage to provide virtually 100 percent negative feedback to the base input of the common emitter stage. Bias to the network is supplied via the common tie point of the common emitter stage collector terminal and the emitter follower base stage terminal by a regulated constant current source, and the output of the circuit is taken from the collector of the emitter follower stage.

Hybridization of Architectural Styles for Integrated Enterprise Information Systems

NASA Astrophysics Data System (ADS)

Bagusyte, Lina; Lupeikiene, Audrone

Current enterprise systems engineering theory does not provide adequate support for the development of information systems on demand. To say more precisely, it is forming. This chapter proposes the main architectural decisions that underlie the design of integrated enterprise information systems. This chapter argues for the extending service-oriented architecture - for merging it with component-based paradigm at the design stage and using connectors of different architectural styles. The suitability of general-purpose language SysML for the modeling of integrated enterprise information systems architectures is described and arguments pros are presented.

Cryogenic Fluid Management Technology Development Roadmaps

NASA Technical Reports Server (NTRS)

Stephens, J. R.; Johnson, W. L.

2017-01-01

Advancement in Cryogenic Fluid Management (CFM) Technologies is essential for achieving NASA's future long duration missions. Propulsion systems utilizing cryogens are necessary to achieve mission success. Current State Of the Art (SOA) CFM technologies enable cryogenic propellants to be stored for several hours. However, some envisioned mission architectures require cryogens to be stored for two years or longer. The fundamental roles of CFM technologies are long term storage of cryogens, propellant tank pressure control and propellant delivery. In the presence of heat, the cryogens will "boil-off" over time resulting in excessive pressure buildup, off-nominal propellant conditions, and propellant loss. To achieve long term storage and tank pressure control, the CFM elements will intercept and/or remove any heat from the propulsion system. All functions are required to perform both with and without the presence of a gravitational field. Which CFM technologies are required is a function of the cryogens used, mission architecture, vehicle design and propellant tank size. To enable NASA's crewed mission to the Martian surface, a total of seventeen CFM technologies have been identified to support an In-Space Stage and a Lander/Ascent Vehicle. Recognizing that FY2020 includes a Decision Point regarding the In-Space Stage Architecture, a set of CFM Technology Development Roadmaps have been created identifying the current Technology Readiness Level (TRL) of each element, current technology "gaps", and existing technology development efforts. The roadmaps include a methodical approach and schedule to achieve a flight demonstration in FY2023, hence maturing CFM technologies to TRL 7 for infusion into the In-Space Stage Preliminary Design.

A Compact, Continuous Adiabatic Demagnetization Refrigerator with High Heat Sink Temperature

NASA Technical Reports Server (NTRS)

Shirron, P. J.; Canavan, E. R.; DiPirro, M. J.; Jackson, M.; Tuttle, J. G.

2003-01-01

In the continuous adiabatic demagnetization refrigerator (ADR), the existence of a constant temperature stage attached to the load breaks the link between the requirements of the load (usually a detector array) and the operation of the ADR. This allows the ADR to be cycled much faster, which yields more than an order of magnitude improvement in cooling power density over single-shot ADRs. Recent effort has focused on developing compact, efficient higher temperature stages. An important part of this work has been the development of passive gas-gap heat switches that transition (from conductive to insulating) at temperatures around 1 K and 4 K without the use of an actively heated getter. We have found that by carefully adjusting available surface area and the number of He-3 monolayers, gas-gap switches can be made to operate passively. Passive operation greatly reduces switching time and eliminates an important parasitic heat load. The current four stage ADR provides 6 micro W of cooling at 50 mK (21 micro W at 100 mK) and weighs less than 8 kg. It operates from a 4.2 K heat sink, which can be provided by an unpumped He bath or many commercially available mechanical cryocoolers. Reduction in critical current with temperature in our fourth stage NbTi magnet presently limits the maximum temperature of our system to approx. 5 K. We are developing compact, low-current Nb3Sn magnets that will raise the maximum heat sink temperature to over 10 K.

Efficiency degradation behaviors of current/thermal co-stressed GaN-based blue light emitting diodes with vertical-structure

NASA Astrophysics Data System (ADS)

Liu, Lilin; Ling, Minjie; Yang, Jianfu; Xiong, Wang; Jia, Weiqing; Wang, Gang

2012-05-01

With this work, we demonstrate a three-stage degradation behavior of GaN based LED chips under current/thermal co-stressing. The three stages in sequence are the initial improvement stage, the platform stage, and the rapid degradation stage, indicating that current/thermal co-stressing activates positive effects and negative ones simultaneously, and the dominant degradation mechanisms evolve with aging time. Degradation mechanisms are discussed. Electric current stress has dual characters: damaging the active layers by generating defects and at the same time improving the p-type conductivity by activating the Mg-dopant. High temperature stresses will promote the effects from electric current stresses. The activation of the Mg-dopant will saturate, whereas the generation of defects is carried on in a progressive way. Other mechanisms, such as deterioration of ohmic contacts, also operate. These mechanisms compete/cooperate with each other and evolve with aging time, resulting in the observed three-stage degradation behavior. There exist risks to predict the lifetime of LEDs by a model with a constant accelerated factor.

Flood-inundation maps for the Mississinewa River at Marion, Indiana, 2013

USGS Publications Warehouse

Coon, William F.

2014-01-01

Digital flood-inundation maps for a 9-mile (mi) reach of the Mississinewa River from 0.75 mi upstream from the Pennsylvania Street bridge in Marion, Indiana, to 0.2 mi downstream from State Route 15 were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Mississinewa River at Marion (station number 03326500). Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site. Flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated by using the current stage-discharge relation at the Mississinewa River streamgage, in combination with water-surface profiles from historic floods and from the current (2002) flood-insurance study for Grant County, Indiana. The hydraulic model was then used to compute seven water-surface profiles for flood stages at 1-fo (ft) intervals referenced to the streamgage datum and ranging from 10 ft, which is near bankfull, to 16 ft, which is between the water levels associated with the estimated 10- and 2-percent annual exceedance probability floods (floods with recurrence interval between 10 and 50 years) and equals the “major flood stage” as defined by the NWS. The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging (lidar) data having a 0.98 ft vertical accuracy and 4.9 ft horizontal resolution) to delineate the area flooded at each water level. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage and forecasted high-flow stages from the NWS, will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Utilizing multiple state variables to improve the dynamic range of analog switching in a memristor

NASA Astrophysics Data System (ADS)

Jeong, YeonJoo; Kim, Sungho; Lu, Wei D.

2015-10-01

Memristors and memristive systems have been extensively studied for data storage and computing applications such as neuromorphic systems. To act as synapses in neuromorphic systems, the memristor needs to exhibit analog resistive switching (RS) behavior with incremental conductance change. In this study, we show that the dynamic range of the analog RS behavior can be significantly enhanced in a tantalum-oxide-based memristor. By controlling different state variables enabled by different physical effects during the RS process, the gradual filament expansion stage can be selectively enhanced without strongly affecting the abrupt filament length growth stage. Detailed physics-based modeling further verified the observed experimental effects and revealed the roles of oxygen vacancy drift and diffusion processes, and how the diffusion process can be selectively enhanced during the filament expansion stage. These findings lead to more desirable and reliable memristor behaviors for analog computing applications. Additionally, the ability to selectively control different internal physical processes demonstrated in the current study provides guidance for continued device optimization of memristor devices in general.

Study of unconventional propulsion system concepts for use in a long range transport

NASA Technical Reports Server (NTRS)

Champagne, G. A.

1973-01-01

The noise level of an uncoventional propulsion system for the next generation of subsonic, long-range transport aircraft is discussed. The desired noise level may be achieved by: (1) a fixed geometry, high bypass ratio turbofan with a geared two-stage fan and advanced acoustic treatment or (2) a moderate bypass ratio turbofan with a variable pitch two-stage fan, variable primary and duct nozzles, and advanced acoustic treatment. The geared fan system meets the noise goal with minimum economic penalty. Comparison of the noise levels at takeoff and landing in combination with the economic penalties required to achieve the lower noise levels at specific noise measuring stations, indicate that both area reduction and current certification prodedures should be used to ascertain the point of diminishing returns in establishing future noise goals.

Technology Requirements for Affordable Single-Stage Rocket Launch Vehicles

NASA Technical Reports Server (NTRS)

Stanley, Douglas O.; Piland, William M.

2004-01-01

A number of manned Earth-to-orbit (ETO) vehicle options for replacing or complementing the current Space Transportation System are being examined under the Advanced Manned Launch System (AMLS) study. The introduction of a reusable single-stage vehicle (SSV) into the U.S. launch vehicle fleet early in the next century could greatly reduce ETO launch costs. As a part of the AMLS study, the conceptual design of an SSV using a wide variety of enhancing technologies has recently been completed and is described in this paper. This paper also identifies the major enabling and enhancing technologies for a reusable rocket-powered SSV and provides examples of the mission payoff potential of a variety of important technologies. This paper also discusses the impact of technology advancements on vehicle margins, complexity, and risk, all of which influence the total system cost.

Verification and Validation of Digitally Upgraded Control Rooms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boring, Ronald; Lau, Nathan

2015-09-01

As nuclear power plants undertake main control room modernization, a challenge is the lack of a clearly defined human factors process to follow. Verification and validation (V&V) as applied in the nuclear power community has tended to involve efforts such as integrated system validation, which comes at the tail end of the design stage. To fill in guidance gaps and create a step-by-step process for control room modernization, we have developed the Guideline for Operational Nuclear Usability and Knowledge Elicitation (GONUKE). This approach builds on best practices in the software industry, which prescribe an iterative user-centered approach featuring multiple cyclesmore » of design and evaluation. Nuclear regulatory guidance for control room design emphasizes summative evaluation—which occurs after the design is complete. In the GONUKE approach, evaluation is also performed at the formative stage of design—early in the design cycle using mockups and prototypes for evaluation. The evaluation may involve expert review (e.g., software heuristic evaluation at the formative stage and design verification against human factors standards like NUREG-0700 at the summative stage). The evaluation may also involve user testing (e.g., usability testing at the formative stage and integrated system validation at the summative stage). An additional, often overlooked component of evaluation is knowledge elicitation, which captures operator insights into the system. In this report we outline these evaluation types across design phases that support the overall modernization process. The objective is to provide industry-suitable guidance for steps to be taken in support of the design and evaluation of a new human-machine interface (HMI) in the control room. We suggest the value of early-stage V&V and highlight how this early-stage V&V can help improve the design process for control room modernization. We argue that there is a need to overcome two shortcomings of V&V in current practice—the propensity for late-stage V&V and the use of increasingly complex psychological assessment measures for V&V.« less

Real-time detection of transients in OGLE-IV with application of machine learning

NASA Astrophysics Data System (ADS)

Klencki, Jakub; Wyrzykowski, Łukasz

2016-06-01

The current bottleneck of transient detection in most surveys is the problem of rejecting numerous artifacts from detected candidates. We present a triple-stage hierarchical machine learning system for automated artifact filtering in difference imaging, based on self-organizing maps. The classifier, when tested on the OGLE-IV Transient Detection System, accepts 97% of real transients while removing up to 97.5% of artifacts.

Assessment of the use of space technology in the monitoring of oil spills and ocean pollution: Executive summary

NASA Technical Reports Server (NTRS)

Alvarado, U. R. (Editor)

1980-01-01

The adequacy of current technology in terms of stage of maturity, of sensing, support systems, and information extraction was assessed relative to oil spills, waste pollution, and inputs to pollution trajectory models. Needs for advanced techniques are defined and the characteristics of a future satellite system are determined based on the requirements of U.S. agencies involved in pollution monitoring.

Status, Plans, and Initial Results for ARES 1 Crew Launch Vehicle Aerodynamics

NASA Technical Reports Server (NTRS)

Huebner, Lawrence D.; Haynes, Davy A.; Taylor, Terry L.; Hall, Robert M.; Pamadi, Bandu N.; Seaford, C. Mark

2006-01-01

Following the completion of NASA's Exploration Systems Architecture Study in August 2004 for the NASA Exploration Systems Mission Directorate (ESMD), the Exploration Launch Office at the NASA Marshall Space Flight Center was assigned project management responsibilities for the design and development of the first vehicle in the architecture, the Ares I Crew Launch Vehicle (CLV), which will be used to launch astronauts to low earth orbit and rendezvous with either the International Space Station or the ESMD s earth departure stage for lunar or other future missions beyond low Earth orbit. The primary elements of the Ares I CLV project are the first stage, the upper stage, the upper stage engine, and vehicle integration. Within vehicle integration is an effort in integrated design and analysis which is comprised of a number of technical disciplines needed to support vehicle design and development. One of the important disciplines throughout the life of the project is aerodynamics. This paper will present the status, plans, and initial results of Ares I CLV aerodynamics as the project was preparing for the Ares I CLV Systems Requirements Review. Following a discussion of the specific interactions with other technical panels and a status of the current activities, the plans for aerodynamic support of the Ares I CLV until the initial crewed flights will be presented.

Tomato seeds maturity detection system based on chlorophyll fluorescence

NASA Astrophysics Data System (ADS)

Li, Cuiling; Wang, Xiu; Meng, Zhijun

2016-10-01

Chlorophyll fluorescence intensity can be used as seed maturity and quality evaluation indicator. Chlorophyll fluorescence intensity of seed coats is tested to judge the level of chlorophyll content in seeds, and further to judge the maturity and quality of seeds. This research developed a detection system of tomato seeds maturity based on chlorophyll fluorescence spectrum technology, the system included an excitation light source unit, a fluorescent signal acquisition unit and a data processing unit. The excitation light source unit consisted of two high power LEDs, two radiators and two constant current power supplies, and it was designed to excite chlorophyll fluorescence of tomato seeds. The fluorescent signal acquisition unit was made up of a fluorescence spectrometer, an optical fiber, an optical fiber scaffolds and a narrowband filter. The data processing unit mainly included a computer. Tomato fruits of green ripe stage, discoloration stage, firm ripe stage and full ripe stage were harvested, and their seeds were collected directly. In this research, the developed tomato seeds maturity testing system was used to collect fluorescence spectrums of tomato seeds of different maturities. Principal component analysis (PCA) method was utilized to reduce the dimension of spectral data and extract principal components, and PCA was combined with linear discriminant analysis (LDA) to establish discriminant model of tomato seeds maturity, the discriminant accuracy was greater than 90%. Research results show that using chlorophyll fluorescence spectrum technology is feasible for seeds maturity detection, and the developed tomato seeds maturity testing system has high detection accuracy.

Technique for Reduction of Environmental Pollution from Construction Wastes

NASA Astrophysics Data System (ADS)

Bakaeva, N. V.; Klimenko, M. Y.

2017-11-01

The results of the research on the negative impact construction wastes have on the urban environment and construction ecological safety are described. The research results are based on the statistical data and indicators calculated with the use of environmental pollution assessment in the restoration system of urban buildings technical conditions. The technique for the reduction of environmental pollution from construction wastes is scientifically based on the analytic summary of scientific and practical results for ecological safety ensuring at major overhaul and current repairs (reconstruction) of the buildings and structures. It is also based on the practical application of the probability theory method, system analysis and disperse system theory. It is necessary to execute some stages implementing the developed technique to reduce environmental pollution from construction wastes. The stages include various steps starting from information collection to the system formation with optimum performance characteristics which are more resource saving and energy efficient for the accumulation of construction wastes from urban construction units. The following tasks are solved under certain studies: basic data collection about construction wastes accumulation; definition and comparison of technological combinations at each system functional stage intended for the reduction of construction wastes discharge into the environment; assessment criteria calculation of resource saving and energy efficiency; optimum working parameters of each implementation stage are created. The urban construction technique implementation shows that the resource saving criteria are from 55.22% to 88.84%; potential of construction wastes recycling is 450 million tons of construction damaged elements (parts).

The SW Sex Phenomenon as an Evolutionary Stage of Cataclysmic Variables

NASA Astrophysics Data System (ADS)

Schmidtobreick, L.

From recent large observing campaigns, one finds that nearly all non- or weakly magnetic cataclysmic variables in the orbital period range between 2.8 and 4 hours are of SW Sex type and as such experience very high mass transfer rates. The evolution of cataclysmic variables as for any interacting binary is driven by angular momentum loss which results in a decrease of the orbital period on evolutionary time scales. In particular, all long-period systems need to cross the SW Sex regime of the orbital period distribution before entering the period gap. This makes the SW Sex phenomenon an evolutionary stage in the life of a cataclysmic variable. Here, I present a short overview of the current state of research on these systems.

Overview of Current Hot Water Propulsion Activities at Berlin University of Technology

NASA Astrophysics Data System (ADS)

Kolditz, M.; Pilz, N.; Adirim, H.; Rudloff, P.; Gorsch, M.; Kron, M.

2004-10-01

The AQUARIUS working group has been founded in 1991 on the initiative of students at the Institute of Aeronautics and Astronautics at Berlin University of Technology. It works mainly on the development, manufacturing and testing of hot water propulsion systems. Upon having launched numerous single stage rockets, a two stage hot water rocket (AQUARIUS X-PRO) was developed and launched for the first time in world history. In order to perform thrust experiments for a deeper understanding of the propulsion efficiency and the influence of varying nozzle parameters on exhaust characteristics, a dedicated hot water test facility has been built. For more than five years,ground-based take-off assistance systems for future reusable launch vehicles have been the subject of intense investigation.

Properties of a two stage adiabatic demagnetization refrigerator

NASA Astrophysics Data System (ADS)

Fukuda, H.; Ueda, S.; Arai, R.; Li, J.; Saito, A. T.; Nakagome, H.; Numazawa, T.

2015-12-01

Currently, many space missions using cryogenic temperatures are being planned. In particular, high resolution sensors such as Transition Edge Sensors need very low temperatures, below 100 mK. It is well known that the adiabatic demagnetization refrigerator (ADR) is one of most useful tools for producing ultra-low temperatures in space because it is gravity independent. We studied a continuous ADR system consisting of 4 stages and demonstrated it could provide continuous temperatures around 100 mK. However, there was some heat leakage from the power leads which resulted in reduced cooling power. Our efforts to upgrade our ADR system are presented. We show the effect of using the HTS power leads and discuss a cascaded Carnot cycle consisting of 2 ADR units.

An improved prognostic model for stage T1a and T1b prostate cancer by assessments of cancer extent

PubMed Central

Rajab, Ramzi; Fisher, Gabrielle; Kattan, Michael W; Foster, Christopher S; Møller, Henrik; Oliver, Tim; Reuter, Victor; Scardino, Peter T; Cuzick, Jack; Berney, Daniel M

2013-01-01

Treatment decisions on prostate cancer diagnosed by trans-urethral resection (TURP) of the prostate are difficult. The current TNM staging system for pT1 prostate cancer has not been re-evaluated for 25 years. Our objective was to optimise the predictive power of tumor extent measurements in TURP of the prostate specimens. A total of 914 patients diagnosed by TURP of the prostate between 1990 and 1996, managed conservatively were identified. The clinical end point was death from prostate cancer. Diagnostic serum prostate-specific antigen (PSA) and contemporary Gleason grading was available. Cancer extent was measured by the percentage of chips infiltrated by cancer. Death rates were compared by univariate and multivariate proportional hazards models, including baseline PSA and Gleason score. The percentage of positive chips was highly predictive of prostate cancer death when assessed as a continuous variable or as a grouped variable on the basis of and including the quintiles, quartiles, tertiles and median groups. In the univariate model, the most informative variable was a four group-split (≤ 10%, >10–25%, > 25–75% and > 75%); (HR = 2.08, 95% CI = 1.8–2.4, P < 0.0001). The same was true in a multivariate model (ΔX2 (1 d.f.) = 15.0, P = 0.0001). The current cutoff used by TNM (< = 5%) was sub-optimal (ΔX2 (1 d.f.) = 4.8, P = 0.023). The current TNM staging results in substantial loss of information. Staging by a four-group subdivision would substantially improve prognostication in patients with early stage disease and also may help to refine management decisions in patients who would do well with conservative treatments. PMID:20834240

Risk Assessment Challenges in the Ares I Upper Stage

NASA Technical Reports Server (NTRS)

Stott, James E.; Ring, Robert W.; Elrada, Hassan A.; Hark, Frank

2007-01-01

NASA Marshall Space Flight Center (MSFC) is currently at work developing hardware and systems for the Ares I rocket that will send future astronauts into orbit. Built on cutting-edge launch technologies, evolved powerful Apollo and Space Shuttle propulsion elements, and decades of NASA spaceflight experience, Ares I is the essential core of a safe, reliable, cost-effective space transportation system -- one that will carry crewed missions back to the moon, on to Mars and out into the solar system. Ares I is an in-line, two-stage rocket configuration topped by the Orion crew vehicle and its launch abort system. In addition to the vehicle's primary mission -carrying crews of four to six astronauts to Earth orbit --Ares I may also use its 25-ton payload capacity to deliver resources and supplies to the International Space Station, or to "park" payloads in orbit for retrieval by other spacecraft bound for the moon or other destinations. Crew transportation to the International Space Station is planned to begin no later than 2014. The first lunar excursion is scheduled for the 2020 timeframe. This paper presents the challenges in designing the Ares I upper stage for reliability and safety while minimizing weight and maximizing performance.

CVD Rhenium Engines for Solar-Thermal Propulsion Systems

NASA Technical Reports Server (NTRS)

Williams, Brian E.; Fortini, Arthur J.; Tuffias, Robert H.; Duffy, Andrew J.; Tucker, Stephen P.

1999-01-01

Solar-thermal upper-stage propulsion systems have the potential to provide specific impulse approaching 900 seconds, with 760 seconds already demonstrated in ground testing. Such performance levels offer a 100% increase in payload capability compared to state-of-the-art chemical upper-stage systems, at lower cost. Although alternatives such as electric propulsion offer even greater performance, the 6- to 18- month orbital transfer time is a far greater deviation from the state of the art than the one to two months required for solar propulsion. Rhenium metal is the only material that is capable of withstanding the predicted thermal, mechanical, and chemical environment of a solar-thermal propulsion device. Chemical vapor deposition (CVD) is the most well-established and cost-effective process for the fabrication of complex rhenium structures. CVD rhenium engines have been successfully constructed for the Air Force ISUS program (bimodal thrust/electricity) and the NASA Shooting Star program (thrust only), as well as under an Air Force SBIR project (thrust only). The bimodal engine represents a more long-term and versatile approach to solar-thermal propulsion, while the thrust-only engines provide a potentially lower weight/lower cost and more near-term replacement for current upper-stage propulsion systems.

The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis.

PubMed

Yue, Hu; Shan, Liu; Bin, Lv

2018-02-19

Despite extensive research on the criteria for the assessment of gastric cancer risk using the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis/Intestinal-Metaplasia Assessment (OLGIM) systems, no comprehensive overview or systematic summary on their use is currently available. To perform a systematic review and meta-analysis to assess the efficacy of the OLGA and OLGIM staging systems in evaluating gastric cancer risk. We searched various databases, including PubMed, EMBASE, Medline, and Cochrane's library, for articles published before March 2017 on the association between OLGA/OLGIM stages and risk of gastric cancer. Statistical analysis was performed using RevMan 5.30 and Stata 14.0, with the odds ratio, risk ratio, and 95% confidence interval as the effect measures. A meta-analysis of six case-control studies and two cohort studies, comprising 2700 subjects, was performed. The meta-analysis of prospective case-control studies demonstrated a significant association between the OLGA/OLGIM stages III/IV and gastric cancer. The Newcastle-Ottawa Scale (NOS) score reflected heterogeneity in the case-control studies on OLGA. Subgroup analysis of high-quality (NOS score ≥ 5) studies showed an association between OLGA stage III/IV and increased risk of gastric cancer; the association was also high in the remaining study with low NOS score. The association between higher stages of gastritis defined by OLGA and risk of gastric cancer was significant. This correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.

Single-stage three-phase boost power factor correction circuit for AC-DC converter

NASA Astrophysics Data System (ADS)

Azazi, Haitham Z.; Ahmed, Sayed M.; Lashine, Azza E.

2018-01-01

This article presents a single-stage three-phase power factor correction (PFC) circuit for AC-to-DC converter using a single-switch boost regulator, leading to improve the input power factor (PF), reducing the input current harmonics and decreasing the number of required active switches. A novel PFC control strategy which is characterised as a simple and low-cost control circuit was adopted, for achieving a good dynamic performance, unity input PF, and minimising the harmonic contents of the input current, at which it can be applied to low/medium power converters. A detailed analytical, simulation and experimental studies were therefore conducted. The effectiveness of the proposed controller algorithm is validated by the simulation results, which were carried out using MATLAB/SIMULINK environment. The proposed system is built and tested in the laboratory using DSP-DS1104 digital control board for an inductive load. The results revealed that the total harmonic distortion in the supply current was very low. Finally, a good agreement between simulation and experimental results was achieved.

Introduction to section 2. Climax-stage magmatism: Growth history Of Kilauea Volcano and its instability

NASA Astrophysics Data System (ADS)

Lipman, Peter W.

On the south flank of Hawai'i Island, frequent eruptions, abundant earthquakes, and rapid ground deformation mark the current locus of volcanism along the Hawaiian Ridge. Kïlauea and Mauna Loa volcanoes are in a tholeiitic shield-building stage, erupting mainly on land. South of Kïlauea, Lö'ihi Seamount has erupted alkalic and transitional basalts that mark the growth of Hawai`i's youngest volcano. Kïlauea is the most active volcano on Earth, and its summit caldera and two rift zones characterize the typical shield stage of Hawaiian volcanoes. Kïlauea's south flank, between the rift zones, is subject to sustained and episodic seaward displacements associated with frequent earthquakes and expressed on land by the Hilina fault system.

Compact high-power optical source for resonant infrared pulsed laser ablation and deposition of polymer materials

NASA Astrophysics Data System (ADS)

Kolev, V. Z.; Duering, M. W.; Luther-Davies, B.; Rode, A. V.

2006-12-01

We propose a novel tuneable table-top optical source as an alternative to the free electron laser currently used for resonant infrared pulsed laser deposition of polymers. It is based on two-stage pulsed optical parametric amplification using MgO doped periodically poled lithium niobate crystals. Gain in excess of 106 in the first stage and pump depletion of 58% in the second stage were achieved when the system was pumped by a high-power Nd:YVO4 picosecond laser source at 1064 nm and seeded by a CW tuneable diode laser at 1530 nm. An average power of 2 W was generated at 3.5 µm corresponding to 1.3 µJ pulse energy.

A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation.

PubMed

Valente, Virgilio; Demosthenous, Andreas; Bayford, Richard

2012-06-01

A significant problem with clinical deep brain stimulation (DBS) is the high variability of its efficacy and the frequency of side effects, related to the spreading of current beyond the anatomical target area. This is the result of the lack of control that current DBS systems offer on the shaping of the electric potential distribution around the electrode. This paper presents a stimulator ASIC with a tripolar current-steering output stage, aiming at achieving more selectivity and field shaping than current DBS systems. The ASIC was fabricated in a 0.35-μ m CMOS technology occupying a core area of 0.71 mm(2). It consists of three current sourcing/sinking channels. It is capable of generating square and exponential-decay biphasic current pulses with five different time constants up to 28 ms and delivering up to 1.85 mA of cathodic current, in steps of 4 μA, from a 12 V power supply. Field shaping was validated by mapping the potential distribution when injecting current pulses through a multicontact DBS electrode in saline.

What are your priorities right now? Identifying service needs across recovery stages to inform service development.

PubMed

Laudet, Alexandre B; White, William

2010-01-01

Substance use disorders (SUD) are, for many, chronic conditions that are typically associated with severe impairments in multiple areas of functioning. "Recovery" from SUD is, for most, a lengthy process; improvements in other areas of functioning do not necessarily follow the attainment of abstinence. The current SUD service model providing intense, short-term, symptom-focused services is ill-suited to address these issues. A recovery-oriented model of care is emerging, which provides coordinated recovery-support services using a chronic-care model of sustained recovery management. Information is needed about substance users' priorities, particularly persons in recovery who are not currently enrolled in treatment, to guide the development of recovery-oriented systems. As a first step in filling this gap, we present qualitative data on current life priorities among a sample of individuals that collectively represent successive recovery stages (N = 356). Findings suggest that many areas of functioning remain challenging long after abstinence is attained, most notably employment and education, family/social relations, and housing. Although the ranking of priorities changes somewhat across recovery stages, employment is consistently the second most important priority, behind working on one's recovery. Study limitations are noted, and the implications of findings for the development and evaluation of recovery-oriented services are discussed.

A physics-based fractional order model and state of energy estimation for lithium ion batteries. Part II: Parameter identification and state of energy estimation for LiFePO4 battery

NASA Astrophysics Data System (ADS)

Li, Xiaoyu; Pan, Ke; Fan, Guodong; Lu, Rengui; Zhu, Chunbo; Rizzoni, Giorgio; Canova, Marcello

2017-11-01

State of energy (SOE) is an important index for the electrochemical energy storage system in electric vehicles. In this paper, a robust state of energy estimation method in combination with a physical model parameter identification method is proposed to achieve accurate battery state estimation at different operating conditions and different aging stages. A physics-based fractional order model with variable solid-state diffusivity (FOM-VSSD) is used to characterize the dynamic performance of a LiFePO4/graphite battery. In order to update the model parameter automatically at different aging stages, a multi-step model parameter identification method based on the lexicographic optimization is especially designed for the electric vehicle operating conditions. As the battery available energy changes with different applied load current profiles, the relationship between the remaining energy loss and the state of charge, the average current as well as the average squared current is modeled. The SOE with different operating conditions and different aging stages are estimated based on an adaptive fractional order extended Kalman filter (AFEKF). Validation results show that the overall SOE estimation error is within ±5%. The proposed method is suitable for the electric vehicle online applications.

Summary of vulnerability related technologies based on machine learning

NASA Astrophysics Data System (ADS)

Zhao, Lei; Chen, Zhihao; Jia, Qiong

2018-04-01

As the scale of information system increases by an order of magnitude, the complexity of system software is getting higher. The vulnerability interaction from design, development and deployment to implementation stages greatly increases the risk of the entire information system being attacked successfully. Considering the limitations and lags of the existing mainstream security vulnerability detection techniques, this paper summarizes the development and current status of related technologies based on the machine learning methods applied to deal with massive and irregular data, and handling security vulnerabilities.

Automatic non-destructive system for quality assurance of welded elements in the aircraft industry

NASA Astrophysics Data System (ADS)

Chady, Tomasz; Waszczuk, Paweł; Szydłowski, Michał; Szwagiel, Mariusz

2018-04-01

Flaws that might be a result of the welding process have to be detected, in order to assure high quality thus reliability of elements exploited in aircraft industry. Currently the inspection stage is conducted manually by a qualified workforce. There are no commercially available systems that could support or replace humans in the flaw detection process. In this paper authors present a novel non-destructive system developed for quality assurance purposes of welded elements utilized in the aircraft industry.

Status and Construction of the Belle II DEPFET pixel system

NASA Astrophysics Data System (ADS)

Lütticke, Florian

2014-06-01

DEpleted P-channel Field Effect Transistor (DEPFET) active pixel detectors combine detection with a first amplification stage in a fully depleted detector, resulting in an superb signal-to-noise ratio even for thin sensors. Two layers of thin (75 micron) silicon DEPFET pixels will be used as the innermost vertex system, very close to the beam pipe in the Belle II detector at the SuperKEKB facility. The status of the 8 million DEPFET pixels detector, latest developments and current system tests will be discussed.

An integrated autonomous rendezvous and docking system architecture using Centaur modern avionics

NASA Technical Reports Server (NTRS)

Nelson, Kurt

1991-01-01

The avionics system for the Centaur upper stage is in the process of being modernized with the current state-of-the-art in strapdown inertial guidance equipment. This equipment includes an integrated flight control processor with a ring laser gyro based inertial guidance system. This inertial navigation unit (INU) uses two MIL-STD-1750A processors and communicates over the MIL-STD-1553B data bus. Commands are translated into load activation through a Remote Control Unit (RCU) which incorporates the use of solid state relays. Also, a programmable data acquisition system replaces separate multiplexer and signal conditioning units. This modern avionics suite is currently being enhanced through independent research and development programs to provide autonomous rendezvous and docking capability using advanced cruise missile image processing technology and integrated GPS navigational aids. A system concept was developed to combine these technologies in order to achieve a fully autonomous rendezvous, docking, and autoland capability. The current system architecture and the evolution of this architecture using advanced modular avionics concepts being pursued for the National Launch System are discussed.

Developments in Test Facility and Data Networking for the Altitude Test Stand at the John C. Stennis Space Center, MS - A General Overview

NASA Technical Reports Server (NTRS)

Hebert, Phillip W., Sr.

2008-01-01

May 2007, NASA's Constellation Program selected John C Stennis Space Center (SSC) near Waveland Mississippi as the site to construct an altitude test facility for the developmental and qualification testing of the Ares1 upper stage (US) engine. Test requirements born out of the Ares1 US propulsion system design necessitate exceptional Data Acquisition System (DAS) design solutions that support facility and propellant systems conditioning, test operations control and test data analysis. This paper reviews the new A3 Altitude Test Facility's DAS design requirements for real-time deterministic digital data, DAS technology enhancements, system trades, technology validation activities, and the current status of this system's new architecture. Also to be discussed will be current network technologies to improve data transfer.

Oropharyngeal cancer and human papilloma virus: evolving diagnostic and management paradigms.

PubMed

Buckley, Lisa; Gupta, Ruta; Ashford, Bruce; Jabbour, Joe; Clark, Jonathan R

2016-06-01

The significant increase in human papilloma virus (HPV)-associated oropharyngeal carcinoma (OPC) over recent years has lead to a surge in research and an improved understanding of the disease. Most patients with HPV-associated OPC present with cystic nodal metastases with a small primary tumour, and respond well to all treatment modalities including primary surgery and primary chemoradiotherapy. Current research is evaluating treatment de-escalation to reduce long-term treatment-associated morbidities. Transoral robotic surgery (TORS) is particularly relevant as the transoral approach allows small primary tumours to be removed with lower morbidity than traditional surgical approaches. The current American Joint Committee on Cancer staging system for oropharyngeal cancer does not appropriately stratify HPV-associated OPC; hence, alternative risk stratification and staging classifications are being proposed. © 2015 Royal Australasian College of Surgeons.

Acid emissions monitoring needs in ceramic tile industry: challenges derived from new policy trends

NASA Astrophysics Data System (ADS)

Celades, Irina; Gomar, Salvador; Romero, Fernando; Chauhan, Amisha; Delpech, Bertrand; Jouhara, Hussam

2017-11-01

The emission of acid compounds during the manufacture of ceramic tiles is strongly related to the presence of precursors in the raw materials and/or fuels used, with some exceptions such as the production of thermal NOX. The stages with the potential to produce significant emissions of these compounds have been identified as the suspension spray drying and tile firing stages. The monitoring of emission levels of acid pollutants in these stages has turned in a great importance issue from a regulatory and industrial aspect. The DREAM project (https://www.spire2030.eu/dream) will tackle the regulation of acidic emissions focusing in the firing stage. The initial stages of the project have made it possible to identify the design requirements for the monitoring system. This will allow the control of acid pollutants emissions and other key parameters such as pressure, flow, temperature and humidity. One of the tasks developed has been the review and compilation of current emissions monitoring systems detailing technical specifications such as: position (in situ or extractive), measurement principle and frequency. The future policy trends in air pollution are encouraging the continuous monitoring across the European industry. The present document assesses the advantages regarding environmental impact control, highlighting the main challenges for the ceramic tile industry.

Recent experimental results of KSTAR RF heating and current drive

NASA Astrophysics Data System (ADS)

Wang, S. J.; Kim, J.; Jeong, J. H.; Kim, H. J.; Joung, M.; Bae, Y. S.; Kwak, J. G.

2015-12-01

The overview of KSTAR activities on ICRH, LHCD and ECH/CD including the last experimental results and future plan aiming for long-pulse high-beta plasma will be presented. Recently we achieved reasonable coupling of ICRF power to H-mode plasma through several efforts to increase system reliability. Power balance will be discussed on this experiment. LHCD is still struggling in the low power regime. Review of antenna spectrum for the higher coupling in H-mode plasma will be tried. ECH/CD provides 41 sec, 0.8 MW of heating power to support high-performance long-pulse discharge. Also, 170 GHz ECH system is integrated with the Plasma Control System (PCS) for the feedback controlling of NTM. Status and plan of ECH/CD will be discussed. Finally, helicon current drive is being prepared for the next stage of KSTAR operation. The hardware preparation and the calculation results of helicon current drive in KSTAR plasma will be discussed.

What can we learn from noise? — Mesoscopic nonequilibrium statistical physics —

PubMed Central

KOBAYASHI, Kensuke

2016-01-01

Mesoscopic systems — small electric circuits working in quantum regime — offer us a unique experimental stage to explorer quantum transport in a tunable and precise way. The purpose of this Review is to show how they can contribute to statistical physics. We introduce the significance of fluctuation, or equivalently noise, as noise measurement enables us to address the fundamental aspects of a physical system. The significance of the fluctuation theorem (FT) in statistical physics is noted. We explain what information can be deduced from the current noise measurement in mesoscopic systems. As an important application of the noise measurement to statistical physics, we describe our experimental work on the current and current noise in an electron interferometer, which is the first experimental test of FT in quantum regime. Our attempt will shed new light in the research field of mesoscopic quantum statistical physics. PMID:27477456

What can we learn from noise? - Mesoscopic nonequilibrium statistical physics.

PubMed

Kobayashi, Kensuke

2016-01-01

Mesoscopic systems - small electric circuits working in quantum regime - offer us a unique experimental stage to explorer quantum transport in a tunable and precise way. The purpose of this Review is to show how they can contribute to statistical physics. We introduce the significance of fluctuation, or equivalently noise, as noise measurement enables us to address the fundamental aspects of a physical system. The significance of the fluctuation theorem (FT) in statistical physics is noted. We explain what information can be deduced from the current noise measurement in mesoscopic systems. As an important application of the noise measurement to statistical physics, we describe our experimental work on the current and current noise in an electron interferometer, which is the first experimental test of FT in quantum regime. Our attempt will shed new light in the research field of mesoscopic quantum statistical physics.

Electromagnetic deep-probing (100-1000 KMS) of the Earth's interior from artificial satellites: Constraints on the regional emplacement of crustal resources

NASA Technical Reports Server (NTRS)

Hermance, J. F. (Principal Investigator)

1982-01-01

The two stages of analysis of MAGSAT magnetic data which are designed to evaluate electromagnetic induction effects are described. The first stage consists of comparison of data from contiguous orbit passes over large scale geologic boundaries, such as ocean-land interfaces, at several levels of magnetic disturbance. The purpose of these comparisons is to separate induction effects from effects of lithospheric magnetization. The procdure for reducing the data includes: (1) identifying and subtracting quiet time effects; (2) modelling and subtracting first order ring current effects; and (3) projecting an orbit track onto a map as a nearly straight line so it can serve as an axis on which to plot the corresponding orbit pass data in the context of geography. The second stage consists of comparison of MAGSAT data with standard hourly observatory data. The purpose is to constrain the time evolution of ionospheric and magnetospheric current systems. Qualitative features of the ground based dataset are discussed. Methods for reducing the ground based data are described.

Nurses' Experiences of an Initial and Reimplemented Electronic Health Record Use.

PubMed

Chang, Chi-Ping; Lee, Ting-Ting; Liu, Chia-Hui; Mills, Mary Etta

2016-04-01

The electronic health record is a key component of healthcare information systems. Currently, numerous hospitals have adopted electronic health records to replace paper-based records to document care processes and improve care quality. Integrating healthcare information system into traditional nursing daily operations requires time and effort for nurses to become familiarized with this new technology. In the stages of electronic health record implementation, smooth adoption can streamline clinical nursing activities. In order to explore the adoption process, a descriptive qualitative study design and focus group interviews were conducted 3 months after and 2 years after electronic health record system implementation (system aborted 1 year in between) in one hospital located in southern Taiwan. Content analysis was performed to analyze the interview data, and six main themes were derived, in the first stage: (1) liability, work stress, and anticipation for electronic health record; (2) slow network speed, user-unfriendly design for learning process; (3) insufficient information technology/organization support; on the second stage: (4) getting used to electronic health record and further system requirements, (5) benefits of electronic health record in time saving and documentation, (6) unrealistic information technology competence expectation and future use. It concluded that user-friendly design and support by informatics technology and manpower backup would facilitate this adoption process as well.

Managing the life cycle of electronic clinical documents.

PubMed

Payne, Thomas H; Graham, Gail

2006-01-01

To develop a model of the life cycle of clinical documents from inception to use in a person's medical record, including workflow requirements from clinical practice, local policy, and regulation. We propose a model for the life cycle of clinical documents as a framework for research on documentation within electronic medical record (EMR) systems. Our proposed model includes three axes: the stages of the document, the roles of those involved with the document, and the actions those involved may take on the document at each stage. The model includes the rules to describe who (in what role) can perform what actions on the document, and at what stages they can perform them. Rules are derived from needs of clinicians, and requirements of hospital bylaws and regulators. Our model encompasses current practices for paper medical records and workflow in some EMR systems. Commercial EMR systems include methods for implementing document workflow rules. Workflow rules that are part of this model mirror functionality in the Department of Veterans Affairs (VA) EMR system where the Authorization/ Subscription Utility permits document life cycle rules to be written in English-like fashion. Creating a model of the life cycle of clinical documents serves as a framework for discussion of document workflow, how rules governing workflow can be implemented in EMR systems, and future research of electronic documentation.

Toward large space systems. [Space Construction Base development from shuttles

NASA Technical Reports Server (NTRS)

Daros, C. J.; Freitag, R. F.; Kline, R. L.

1977-01-01

The design of the Space Transportation System, consisting of the Space Shuttle, Spacelab, and upper stages, provides experience for the development of more advanced space systems. The next stage will involve space stations in low earth orbit with limited self-sufficiency, characterized by closed ecological environments, space-generated power, and perhaps the first use of space materials. The third phase would include manned geosynchronous space-station activity and a return to lunar operations. Easier access to space will encourage the use of more complex, maintenance-requiring satellites than those currently used. More advanced space systems could perform a wide range of public services such as electronic mail, personal and police communication, disaster control, earthquake detection/prediction, water availability indication, vehicle speed control, and burglar alarm/intrusion detection. Certain products, including integrated-circuit chips and some enzymes, can be processed to a higher degree of purity in space and might eventually be manufactured there. Hardware including dishes, booms, and planar surfaces necessary for advanced space systems and their development are discussed.

Development of a 30-50 K dual-stage pulse tube space cooler

NASA Astrophysics Data System (ADS)

Leenders, H.; de Jonge, G.; Mullié, J.; Prouvé, T.; Charles, I.; Trollier, T.; Tanchon, J.

2017-12-01

There has been a trend towards increasing heat loads for cryogenically cooled Earth Observation instruments in recent years. This is the case at both the current operational temperature levels (∼50K), as well as at lower operational temperature levels (30-50 K). One solution to meet this trend is to use existing pulse tube technology in a double stage configuration. With such technology increased cooling power at a lower temperature can be achieved at the payload detector. Another advantage of such a system is the possibility to increase overall system efficiency by cooling an intermediate shield to avoid parasitic heat losses towards the detector. Therefore a consortium consisting of Thales Cryogenics B.V. (TCBV), Alternative Energies and Atomic Energy Commission (CEA) and Absolut System (AS) is working on the development of a space cryostat actively cooled by a 2-stage high reliability pulse tube cryocooler. This work is being performed in the frame of an European Space Agency (ESA) Technical Research Program (TRP) (refer 4000109933/14/NL/RA) with a target TRL of 6. This paper presents the design of the overall equipped cryostat and cryostat itself but is mainly focused on the 2-stage cryocooler. Design, manufacturing and test aspects of cryocooler and its the lower level components such as the compressor and cold finger are discussed in detail in this paper. The cryocooler test campaign is meanwhile in final stages of completion and the obtained test results are in line with program objectives.

Development of advanced fluid-bed agglomeration and cyclonic incineration for simultaneous waste disposal and energy recovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rehmat, A.; Khinkis, M.

The Institute of Gas Technology (IGT) is currently developing a two-stage fluidized-bed/cyclonic agglomerating incineration system for waste disposal that is based on combining the fluidized-bed agglomeration/incineration and cyclonic combustion techologies. Both technologies have been developed individually at IGT over many years. This combination has resulted in a unique and extremely flexible incinerator for solid, liquid, and gaseous wastes including municipal sludges. The system can operate over a wide range of conditions in the first stage, from low temperature (desorption) to high temperature (agglomeration), including gasification of wastes. In the combined system, solid, liquid, and gaseous organic wastes are incinerated withmore » ease and great efficiency (>99.99% destruction and removal efficiency (DRE)), while solid inorganic contaminants contained within a glassy matrix are rendered benign and suitable for disposal in an ordinary landfill. The heat generated within the incinerator can be recovered using the state-of-the-art boilers. The development of the two-stage incinerator is a culmination of extensive research and development efforts on each stage of the incinerator. The variety of data obtained with solid, liquid, and gaseous wastes for both stages includes agglomeration of ash, incineration and reclamation of used blast grit and foundry sand, partial combustion of carbonaceous fuels, in-situ desulfurization, combustion of low-Btu gases, incineration of industrial wastewater, and incineration of carbon tetrachloride. 5 refs., 7 figs., 12 tabs.« less

Low Earth Orbit satellite/terrestrial mobile service compatibility

NASA Technical Reports Server (NTRS)

Sheriff, Ray E.; Gardiner, John G.

1993-01-01

Currently the geostationary type of satellite is the only one used to provide commercial mobile-satellite communication services. Low earth orbit (LEO) satellite systems are now being proposed as a future alternative. By the implementation of LEO satellite systems, predicted at between 5 and 8 years time, mobile space/terrestrial technology will have progressed to the third generation stage of development. This paper considers the system issues that will need to be addressed when developing a dual mode terminal, enabling access to both terrestrial and LEO satellite systems.

Recent progress of TAMA300

NASA Astrophysics Data System (ADS)

Arai, K.; TAMA Collaboration

2008-07-01

Current effort of the TAMA project is focused on establishment of the interferometer operation with a new vibration isolation system, called 'Seismic Attenuation System' (SAS). The SAS employs a multiple stage structure to realize soft spring for all of directions, as well as utilizes active control systems to stabilize mechanical resonances in the low frequency region below 1 Hz. The SASs were installed for four test masses, resulting in improvement of cavity length fluctuation below 150 Hz. We describe the structure of the SAS and its local active control system, and the status of the interferometer.

Programmer's reference manual for the VAX-Gerber link software package. Revision 1. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isobe, G.W.

1985-10-01

This guide provides the information necessary to edit, modify, and run the VAX-Gerber software link. Since the project is in the testing stage and still being modified, this guide discussess the final desired stage along with the current stage. The current stage is to set up as to allow the programmer to easily modify and update codes as necessary.

Islet cell transplant: Update on current clinical trials

PubMed Central

Schuetz, Christian; Markmann, James F.

2016-01-01

In the last 15 years clinical islet transplantation has made the leap from experimental procedure to standard of care for a highly selective group of patients. Due to a risk-benefit calculation involving the required systemic immunosuppression the procedure is only considered in patients with type 1 diabetes, complicated by severe hypoglycemia or end stage renal disease. In this review we summarize current outcomes of the procedure and take a look at ongoing and future improvements and refinements of beta cell therapy. PMID:28451515

Push-pull with recovery stage high-voltage DC converter for PV solar generator

NASA Astrophysics Data System (ADS)

Nguyen, The Vinh; Aillerie, Michel; Petit, Pierre; Pham, Hong Thang; Vo, Thành Vinh

2017-02-01

A lot of systems are basically developed on DC-DC or DC-AC converters including electronic switches such as MOS or bipolar transistors. The limits of efficiency are quickly reached when high output voltages and high input currents are needed. This work presents a new high-efficiency-high-step-up based on push-pull DC-DC converter integrating recovery stages dedicated to smart HVDC distributed architecture in PV solar energy production systems. Appropriate duty cycle ratio assumes that the recovery stage work with parallel charge and discharge to achieve high step-up voltage gain. Besides, the voltage stress on the main switch is reduced with a passive clamp circuit and thus, low on-state resistance Rdson of the main switch can be adopted to reduce conduction losses. Thus, the efficiency of a basic DC-HVDC converter dedicated to renewable energy production can be further improved with such topology. A prototype converter is developed, and experimentally tested for validation.

Designed synthesis of double-stage two-dimensional covalent organic frameworks

PubMed Central

Chen, Xiong; Addicoat, Matthew; Jin, Enquan; Xu, Hong; Hayashi, Taku; Xu, Fei; Huang, Ning; Irle, Stephan; Jiang, Donglin

2015-01-01

Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers in which organic building blocks are covalently and topologically linked to form extended crystalline polygon structures, constituting a new platform for designing π-electronic porous materials. However, COFs are currently synthesised by a few chemical reactions, limiting the access to and exploration of new structures and properties. The development of new reaction systems that avoid such limitations to expand structural diversity is highly desired. Here we report that COFs can be synthesised via a double-stage connection that polymerises various different building blocks into crystalline polygon architectures, leading to the development of a new type of COFs with enhanced structural complexity and diversity. We show that the double-stage approach not only controls the sequence of building blocks but also allows fine engineering of pore size and shape. This strategy is widely applicable to different polymerisation systems to yield hexagonal, tetragonal and rhombus COFs with predesigned pores and π-arrays. PMID:26456081

Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick.

PubMed

Chan-Thomas, P S; Thompson, R P; Robert, B; Yacoub, M H; Barton, P J

1993-07-01

The vertebrate homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during embryogenesis. We have examined their expression by in situ hybridisation during critical stages of cardiac development in the chick from stages 15+ to 37. Msx-1 expression is apparent in a number of non-myocardial cell populations, including cells undergoing an epithelial to mesenchymal transformation in the atrioventricular and the outflow tract regions that play an integral role in heart septation and valve formation. Msx-2 expression is restricted to a distinct subpopulation of myocardial cells that, in later stages, coincides morphologically with the cardiac conduction system. The timing of Msx-2 expression suggests that it plays a role in conduction system tissue formation and that it identifies precursor cells of this specialised myocardium. The pattern of Msx-2 expression is discussed with reference to current models of conduction tissue development.

Designed synthesis of double-stage two-dimensional covalent organic frameworks

NASA Astrophysics Data System (ADS)

Chen, Xiong; Addicoat, Matthew; Jin, Enquan; Xu, Hong; Hayashi, Taku; Xu, Fei; Huang, Ning; Irle, Stephan; Jiang, Donglin

2015-10-01

Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers in which organic building blocks are covalently and topologically linked to form extended crystalline polygon structures, constituting a new platform for designing π-electronic porous materials. However, COFs are currently synthesised by a few chemical reactions, limiting the access to and exploration of new structures and properties. The development of new reaction systems that avoid such limitations to expand structural diversity is highly desired. Here we report that COFs can be synthesised via a double-stage connection that polymerises various different building blocks into crystalline polygon architectures, leading to the development of a new type of COFs with enhanced structural complexity and diversity. We show that the double-stage approach not only controls the sequence of building blocks but also allows fine engineering of pore size and shape. This strategy is widely applicable to different polymerisation systems to yield hexagonal, tetragonal and rhombus COFs with predesigned pores and π-arrays.

Characterization of a Two-Stage Pulse Tube Cooler for Space Applications

NASA Astrophysics Data System (ADS)

Orsini, R.; Nguyen, T.; Colbert, R.; Raab, J.

2010-04-01

A two-stage long-life, low mass and efficient pulse tube cooler for space applications has been developed and acceptance tested for flight applications. This paper presents the data collected on four flight coolers during acceptance testing. Flight acceptance test of these cryocoolers includes thermal performance mapping over a range of reject temperatures, launch vibration testing and thermal cycling testing. Designed conservatively for a 10-year life, the coolers are required to provide simultaneous cooling powers at 95 K and 180 K while rejecting to 300 K with less than 187 W input power to the electronics. The total mass of each cooler and electronics system is 8.7 kg. The radiation-hardened and software driven control electronics provides cooler control functions which are fully re-configurable in orbit. These functions include precision temperature control to better than 100 mK p-p. This 2 stage cooler has heritage to the 12 Northrop Grumman Aerospace Systems (NGAS) coolers currently on orbit with 2 operating for more than 11.5 years.

Low noise constant current source for bias dependent noise measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Talukdar, D.; Bose, Suvendu; Bardhan, K. K.

2011-01-15

A low noise constant current source used for measuring the 1/f noise in disordered systems in ohmic as well as nonohmic regime is described. The source can supply low noise constant current starting from as low as 1 {mu}A to a few tens of milliampere with a high voltage compliance limit of around 20 V. The constant current source has several stages, which can work in a standalone manner or together to supply the desired value of load current. The noise contributed by the current source is very low in the entire current range. The fabrication of a low noisemore » voltage preamplifier modified for bias dependent noise measurements and based on the existing design available in the MAT04 data sheet is also described.« less

A CMOS power-efficient low-noise current-mode front-end amplifier for neural signal recording.

PubMed

Wu, Chung-Yu; Chen, Wei-Ming; Kuo, Liang-Ting

2013-04-01

In this paper, a new current-mode front-end amplifier (CMFEA) for neural signal recording systems is proposed. In the proposed CMFEA, a current-mode preamplifier with an active feedback loop operated at very low frequency is designed as the first gain stage to bypass any dc offset current generated by the electrode-tissue interface and to achieve a low high-pass cutoff frequency below 0.5 Hz. No reset signal or ultra-large pseudo resistor is required. The current-mode preamplifier has low dc operation current to enhance low-noise performance and decrease power consumption. A programmable current gain stage is adopted to provide adjustable gain for adaptive signal scaling. A following current-mode filter is designed to adjust the low-pass cutoff frequency for different neural signals. The proposed CMFEA is designed and fabricated in 0.18-μm CMOS technology and the area of the core circuit is 0.076 mm(2). The measured high-pass cutoff frequency is as low as 0.3 Hz and the low-pass cutoff frequency is adjustable from 1 kHz to 10 kHz. The measured maximum current gain is 55.9 dB. The measured input-referred current noise density is 153 fA /√Hz , and the power consumption is 13 μW at 1-V power supply. The fabricated CMFEA has been successfully applied to the animal test for recording the seizure ECoG of Long-Evan rats.

Space Launch System Upper Stage Technology Assessment

NASA Technical Reports Server (NTRS)

Holladay, Jon; Hampton, Bryan; Monk, Timothy

2014-01-01

The Space Launch System (SLS) is envisioned as a heavy-lift vehicle that will provide the foundation for future beyond low-Earth orbit (LEO) exploration missions. Previous studies have been performed to determine the optimal configuration for the SLS and the applicability of commercial off-the-shelf in-space stages for Earth departure. Currently NASA is analyzing the concept of a Dual Use Upper Stage (DUUS) that will provide LEO insertion and Earth departure burns. This paper will explore candidate in-space stages based on the DUUS design for a wide range of beyond LEO missions. Mission payloads will range from small robotic systems up to human systems with deep space habitats and landers. Mission destinations will include cislunar space, Mars, Jupiter, and Saturn. Given these wide-ranging mission objectives, a vehicle-sizing tool has been developed to determine the size of an Earth departure stage based on the mission objectives. The tool calculates masses for all the major subsystems of the vehicle including propellant loads, avionics, power, engines, main propulsion system components, tanks, pressurization system and gases, primary structural elements, and secondary structural elements. The tool uses an iterative sizing algorithm to determine the resulting mass of the stage. Any input into one of the subsystem sizing routines or the mission parameters can be treated as a parametric sweep or as a distribution for use in Monte Carlo analysis. Taking these factors together allows for multi-variable, coupled analysis runs. To increase confidence in the tool, the results have been verified against two point-of-departure designs of the DUUS. The tool has also been verified against Apollo moon mission elements and other manned space systems. This paper will focus on trading key propulsion technologies including chemical, Nuclear Thermal Propulsion (NTP), and Solar Electric Propulsion (SEP). All of the key performance inputs and relationships will be presented and discussed in light of the various missions. For each mission there are several trajectory options and each will be discussed in terms of delta-v required and transit duration. Each propulsion system will be modeled, sized, and judged based on their applicability to the whole range of beyond LEO missions. Criteria for scoring will include the resulting dry mass of the stage, resulting propellant required, time to destination, and an assessment of key enabling technologies. In addition to the larger metrics, this paper will present the results of several coupled sensitivity studies. The ultimate goals of these tools and studies are to provide NASA with the most mass-, technology-, and cost-effective in-space stage for its future exploration missions.

NASA Earth-to-Orbit Engineering Design Challenges: Thermal Protection Systems

ERIC Educational Resources Information Center

National Aeronautics and Space Administration (NASA), 2010

2010-01-01

National Aeronautics and Space Administration (NASA) Engineers at Marshall Space Flight Center, Dryden Flight Research Center, and their partners at other NASA centers and in private industry are currently developing X-33, a prototype to test technologies for the next generation of space transportation. This single-stage-to-orbit reusable launch…

Virology, Immunology, and Clinical Course of HIV Infection.

ERIC Educational Resources Information Center

McCutchan, J. Allen

1990-01-01

Presents overview of medical aspects of human immunodeficiency virus Type 1 (HIV-1) disease. Addresses structure and replication of virus, current methods for detecting HIV-1 in infected persons, effects of the virus on immune system, and clinical course of HIV-1 disease. Emphasizes variable causes of progression through HIV-1 infection stages;…

State Systemic Education Improvements. Status Report.

ERIC Educational Resources Information Center

Council of Chief State School Officers, Washington, DC.

The Council of Chief State School Officers (CCSSO) is a nationwide, nonprofit organization of the 57 public officials who head departments of public education in the United States, 5 U.S. extra-state jurisdiction, the District of Columbia, and the Department of Defense Dependents Schools. States are currently at various stages in developing and…

Solar Thermal Propulsion Concept

NASA Technical Reports Server (NTRS)

2004-01-01

Harnessing the Sun's energy through Solar Thermal Propulsion will propel vehicles through space by significantly reducing weight, complexity, and cost while boosting performance over current conventional upper stages. Another solar powered system, solar electric propulsion, demonstrates ion propulsion is suitable for long duration missions. Pictured is an artist's concept of space flight using solar thermal propulsion.

A Novel CAI System for Space Conceptualization Training in Perspective Sketching

ERIC Educational Resources Information Center

Luh, Ding-Bang; Chen, Shao-Nung

2013-01-01

For many designers, freehand sketching is the primary tool for conceptualization in the early stage of the design process. However, current education on concept presentation techniques rarely emphasizes the construction of the most fundamental spatial unit, the cube. Incorrect construction of spatial units leads to disproportions that deviate from…

Drinking Water Disinfection By-Product Rules and Climate Change Effects - A Glimpse of Current and Future Trends

EPA Science Inventory

"Drinking water quality at the consumer's tap is the center piece of U.S. drinking water regulations to protect people's health. Recently promulgated Stage II DBP rules are an example, which requires a system approach in a multi-barrier strategy for compliance and risk managemen...

Incorporation of N0 Stage with Insufficient Numbers of Lymph Nodes into N1 Stage in the Seventh Edition of the TNM Classification Improves Prediction of Prognosis in Gastric Cancer: Results of a Single-Institution Study of 1258 Chinese Patients.

PubMed

Li, Bofei; Li, Yuanfang; Wang, Wei; Qiu, Haibo; Seeruttun, Sharvesh Raj; Fang, Cheng; Chen, Yongming; Liang, Yao; Li, Wei; Chen, Yingbo; Sun, Xiaowei; Guan, Yuanxiang; Zhan, Youqing; Zhou, Zhiwei

2016-01-01

This study examined the prognosis of the "node-negative with eLNs ≤ 15" designation and the additional value of incorporating it into the pN1 designation in the seventh edition of the N classification. From January 2000 to September 2010, a total of 1258 gastric cancer patients (patients with eLNs > 15 or node-negative with eLNs ≤ 15) undergoing radical gastric resection were enrolled in this study. We incorporated node-negative patients with eLNs ≤ 15 into pN1 and compared this designation with the current 7th edition UICC N stage for 3, 5-year overall survival by univariate and multivariate analysis. Homogeneity, discriminatory ability, and monotonicity of gradients in the hypothetical N stage and the UICC N stage were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations. Node-negative patients with eLNs ≤ 15 had worse survival compared with those with eLNs > 15. In univariate and multivariate analyses, the hypothetical N stage showed superiority to the 7th edition pN staging. The hypothetical staging system had higher linear trend and likelihood ratio χ (2) scores and smaller AIC values compared with those for the TNM system, which represented the optimum prognostic stratification. Node-negative patients with eLNs ≤ 15 can be considered to be incorporated into the pN1 stage in the 7th edition of the TNM classification.

High-energy extracorporeal shock wave therapy for nontraumatic osteonecrosis of the femoral head.

PubMed

Xie, Kai; Mao, Yuanqing; Qu, Xinhua; Dai, Kerong; Jia, Qingwei; Zhu, Zhenan; Yan, Mengning

2018-02-02

Nontraumatic osteonecrosis of the femoral head (ONFH) is treated with a series of methods. High-energy extracorporeal shock wave therapy (ESWT) is an option with promising mid-term outcomes. The objective of this study was to determine the long-term outcomes of ESWT for ONFH. Fifty-three hips in 39 consecutive patients were treated with ESWT in our hospital between January 2005 and July 2006. Forty-four hips in 31 patients with stage I-III nontraumatic ONFH, according to the Association Research Circulation Osseous (ARCO) system, were reviewed in the current retrospective study. The visual analog pain scale (VAS), Harris hip score, radiography, and magnetic resonance imaging were used to estimate treatment results. The progression of ONFH was evaluated by imaging examination and clinical outcomes. The results were classified as clinical success (no progression of hip symptoms) and imaging success (no progression of stage or substage on radiography and MRI). The mean follow-up duration was 130.6 months (range, 121 to 138 months). The mean VAS decreased from 3.8 before ESWT to 2.2 points at the 10-year follow-up (p < 0.001). The mean Harris hip score improved from 77.4 before ESWT to 86.9 points at the 10-year follow-up. The clinical success rates were 87.5% in ARCO stage I patients, 71.4% in ARCO stage II patients, and 75.0% in ARCO stage III patients. Imaging success was observed in all stage I hips, 64.3% of stage II hips, and 12.5% of stage III hips. Seventeen hips showed progression of the ARCO stage/substage on imaging examination. Eight hips showed femoral head collapse at the 10-year follow-up. Four hips in ARCO stage III and one hip in ARCO stage II were treated with total hip arthroplasty during the follow-up. Three were performed 1 year after ESWT, one at 2 years, and one at 5 years. The results of the current study indicated that ESWT is an effective treatment method for nontraumatic ONFH, resulting in pain relief and function restoration, especially for patients with ARCO stage I-II ONFH.

Further characterisation of the functional neuroanatomy associated with prosodic emotion decoding.

PubMed

Mitchell, Rachel L C

2013-06-01

Current models of prosodic emotion comprehension propose a three stage cognition mediated by temporal lobe auditory regions through to inferior and orbitofrontal regions. Cumulative evidence suggests that its mediation may be more flexible though, with a facility to respond in a graded manner based on the need for executive control. The location of this fine-tuning system is unclear, as is its similarity to the cognitive control system. In the current study, need for executive control was manipulated in a block-design functional MRI study by systematically altering the proportion of incongruent trials across time, i.e., trials for which participants identified prosodic emotions in the face of conflicting lexico-semantic emotion cues. Resultant Blood Oxygenation Level Dependent contrast data were analysed according to standard procedures using Statistical Parametric Mapping v8 (Ashburner et al., 2009). In the parametric analyses, superior (medial) frontal gyrus activity increased linearly with increased need for executive control. In the separate analyses of each level of incongruity, results suggested that the baseline prosodic emotion comprehension system was sufficient to deal with low proportions of incongruent trials, whereas a more widespread frontal lobe network was required for higher proportions. These results suggest an executive control system for prosodic emotion comprehension exists which has the capability to recruit superior (medial) frontal gyrus in a graded manner and other frontal regions once demand exceeds a certain threshold. The need to revise current models of prosodic emotion comprehension and add a fourth processing stage are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Flood-inundation maps for Peachtree Creek from the Norfolk Southern Railway bridge to the Moores Mill Road NW bridge, Atlanta, Georgia

USGS Publications Warehouse

Musser, Jonathan W.

2012-01-01

Digital flood-inundation maps for a 5.5-mile reach of the Peachtree Creek from the Norfolk Southern Railway bridge to the Moores Mill Road NW bridge, were developed by the U.S. Geological Survey (USGS) in cooperation with the City of Atlanta, Georgia. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Peachtree Creek at Atlanta, Georgia (02336300) and the USGS streamgage at Chattahoochee River at Georgia 280, near Atlanta, Georgia (02336490). Current water level (stage) at these USGS streamgages may be obtained at http://waterdata.usgs.gov/ and can be used in conjunction with these maps to estimate near real-time areas of inundation. The National Weather Service (NWS) is incorporating results from this study into the Advanced Hydrologic Prediction Service (AHPS) flood warning system (http:/water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that commonly are collocated at USGS streamgages. The forecasted peak-stage information for the USGS streamgage at Peachtree Creek, which is available through the AHPS Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. A one-dimensional step-backwater model was developed using the U.S. Army Corps of Engineers HEC–RAS software for a 6.5-mile reach of Peachtree Creek and was used to compute flood profiles for a 5.5-mile reach of the creek. The model was calibrated using the most current stage-discharge relations at the Peachtree Creek at Atlanta, Georgia, streamgage (02336300), and the Chattahoochee River at Georgia 280, near Atlanta, Georgia, streamgage (02336490) as well as high water marks collected during the 2010 annual peak flow event. The hydraulic model was then used to determine 50 water-surface profiles. The profiles are for 10 flood stages at the Peachtree Creek streamgage at 1-foot intervals referenced to the streamgage datum and ranging from just above bankfull stage (15.0 feet) to approximately the highest recorded water level at the streamgage (24.0 feet). At each stage on Peachtree Creek, five stages at the Chattahoochee River streamgage, from 26.4 feet to 38.4 feet in 3-foot intervals, were used to determine backwater effects. The simulated water-surface profiles were then combined with a geographic information system digital elevation model—derived from Light Detection and Ranging (LiDAR) data having a 0.3-foot vertical and 16.4-foot horizontal resolution—to delineate the area flooded for each 1-foot increment of stream stage. The availability of these maps, when combined with real-time information regarding current stage from USGS streamgages and forecasted stream stages from the NWS, provide emergency management personnel and residents with critical information during flood response activities, such as evacuations and road closures as well as for postflood-recovery efforts.

Orbital Transfer Vehicle (OTV) engine study. Phase A: Extension

NASA Technical Reports Server (NTRS)

Sobin, A. J.

1980-01-01

The current Phase A-Extension of the OTV engine study program aims to provide additional expander and staged combustion cycle data that will lead to design definition of the OTV engine. The proposed program effort seeks to optimize the expander cycle engine concept (consistent with identified OTV engine requirements), investigate the feasibility of kitting the staged combustion cycle engine to provide extended thrust operation, and conduct in-depth analysis of development risk, crew safety, and reliability for both cycles. Additional tasks address the costing of a 10/K thrust expander cycle engine and support of OTV systems study contractors.

Pegasus air-launched space booster

NASA Astrophysics Data System (ADS)

Lindberg, Robert E.; Mosier, Marty R.

The launching of small satellites with the mother- aircraft-launched Pegasus booster yields substantial cost improvements over ground launching and enhances operational flexibility, since it allows launches to be conducted into any orbital inclination. The Pegasus launch vehicle is a three-stage solid-rocket-propelled system with delta-winged first stage. The major components of airborne support equipment, located on the mother aircraft, encompass a launch panel operator console, an electronic pallet, and a pylon adapter. Alternatives to the currently employed B-52 launch platform aircraft have been identified for future use. Attention is given to the dynamic, thermal, and acoustic environments experienced by the payload.

[Inflammasome and its role in immunological and inflammatory response at early stage of burns].

PubMed

Zhang, Fang; Li, Jiahui; Xia, Zhaofan

2014-06-01

Inflammasomes are large multi-protein complexes that serve as a platform for caspase-1 activation, and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18, as well as pyroptosis. As an important component of the innate immune system, early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury. Here, we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.

System for monitoring the growth of crystalline films on stationary substrates

DOEpatents

Sheldon, P.

1996-12-31

A system for monitoring the growth of crystalline films on stationary or rotating substrates includes a combination of some or all of the elements including a photodiode sensor for detecting the intensity of incoming light and converting it to a measurable current, a lens for focusing the RHEED pattern emanating from the phosphor screen onto the photodiode, an interference filter for filtering out light other than that which emanates from the phosphor screen, a current amplifier for amplifying and convening the current produced by the photodiode into a voltage, a computer for receiving the amplified photodiode current for RHEED data analysis, and a graphite impregnated triaxial cable for improving the signal to noise ratio obtained while sampling a stationary or rotating substrate. A rotating stage for supporting the substrate with diametrically positioned electron beam apertures and an optically encoded shaft can also be used to accommodate rotation of the substrate during measurement. 16 figs.

System for monitoring the growth of crystalline films on stationary substrates

DOEpatents

Sheldon, P.

1995-10-10

A system for monitoring the growth of crystalline films on stationary or rotating substrates includes a combination of some or all of the elements including a photodiode sensor for detecting the intensity of incoming light and converting it to a measurable current, a lens for focusing the RHEED pattern emanating from the phosphor screen onto the photodiode, an interference filter for filtering out light other than that which emanates from the phosphor screen, a current amplifier for amplifying and converting the current produced by the photodiode into a voltage, a computer for receiving the amplified photodiode current for RHEED data analysis, and a graphite impregnated triaxial cable for improving the signal-to-noise ratio obtained while sampling a stationary or rotating substrate. A rotating stage for supporting the substrate with diametrically positioned electron beam apertures and an optically encoded shaft can also be used to accommodate rotation of the substrate during measurement. 16 figs.

System for monitoring the growth of crystalline films on stationary substrates

DOEpatents

Sheldon, Peter

1995-01-01

A system for monitoring the growth of crystalline films on stationary or rotating substrates includes a combination of some or all of the elements including a photodiode sensor for detecting the intensity of incoming light and converting it to a measurable current, a lens for focusing the RHEED pattern emanating from the phosphor screen onto the photodiode, an interference filter for filtering out light other than that which emanates from the phosphor screen, a current amplifier for amplifying and converting the current produced by the photodiode into a voltage, a computer for receiving the amplified photodiode current for RHEED data analysis, and a graphite impregnated triax cable for improving the signal to noise ratio obtained while sampling a stationary or rotating substrate. A rotating stage for supporting the substrate with diametrically positioned electron beam apertures and an optically encoded shaft can also be used to accommodate rotation of the substrate during measurement.

System for monitoring the growth of crystalline films on stationary substrates

DOEpatents

Sheldon, Peter

1996-01-01

A system for monitoring the growth of crystalline films on stationary or rotating substrates includes a combination of some or all of the elements including a photodiode sensor for detecting the intensity of incoming light and converting it to a measurable current, a lens for focusing the RHEED pattern emanating from the phosphor screen onto the photodiode, an interference filter for filtering out light other than that which emanates from the phosphor screen, a current amplifier for amplifying and convening the current produced by the photodiode into a voltage, a computer for receiving the amplified photodiode current for RHEED data analysis, and a graphite impregnated triax cable for improving the signal to noise ratio obtained while sampling a stationary or rotating substrate. A rotating stage for supporting the substrate with diametrically positioned electron beam apertures and an optically encoded shaft can also be used to accommodate rotation of the substrate during measurement.

Can extracapsular lymph node involvement be a tool to fine-tune pN1 for adenocarcinoma of the oesophagus and gastro-oesophageal junction in the Union Internationale contre le Cancer (UICC) TNM 7th edition?†.

PubMed

Nafteux, Philippe; Lerut, Toni; De Hertogh, Gert; Moons, Johnny; Coosemans, Willy; Decker, Georges; Van Veer, Hans; De Leyn, Paul

2014-06-01

The current (7th) International Union Against Cancer (UICC) pN staging system is based on the number of positive lymph nodes but does not take into consideration the characteristics of the metastatic lymph nodes itself. In particular, it has been suggested that tumour penetration beyond the lymph node capsule in metastatic lymph nodes, which is also called extracapsular lymph node involvement, has a prognostic impact. The aim of the current study was to assess the prognostic value of extracapsular (EC) and intracapsular (IC) lymph node involvement (LNI) in adenocarcinoma of the oesophagus and gastro-oesophageal junction (GOJ) and to assess its potential impact on the 7th edition of the UICC TNM manual. From 2000 to 2010, all consecutive adenocarcinoma patients with primary R0-resection (n = 499) were prospectively included for analysis. The number of resected lymph nodes, number of positive lymph nodes and number of EC-LNI/IC-LNI were determined. Extracapsular spread was defined as infiltration of cancer cells beyond the capsule of the positive lymph node. Two hundred and eighteen (43%) patients had positive lymph nodes. Cancer-specific 5-year survival in lymph node-positive patients was significantly (P < 0.0001) worse compared with lymph node-negative patients, being 88.3 vs 28.7%, respectively. In 128 (58.7%) cases EC-LNI was detected. EC-LNI showed significantly worse cancer-specific 5-year survival compared with IC-LNI, 19.6 vs 44.0% (P < 0.0001). In the pN1 category (1 or 2 positive LN's-UICC stages IIB and IIIA), this was 30.4% vs 58%; (P = 0.029). In higher pN categories, this effect was no longer noticed. Integrating these findings into an adapted TNM classification resulted in improved homogeneity, monotonicity of gradients and discriminatory ability indicating an improved performance of the staging system. EC-LNI is associated with worse survival compared with IC-LNI. EC-LNI patients show survival rates that are more closely associated with the current TNM stage IIIB, while IC-LNI patients have a survival more similar to TNM stage IIB. Incorporating the EC-IC factor in the TNM classification results in an increased performance of the TNM model. Further confirmation from other centres is required within the context of future adaptations of the UICC/AJCC (American Joint Committee on Cancer) staging system for oesophageal cancer. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

SynchroPhasor Measurements: System Architecture and Performance Evaluation in Supporting Wide-Area Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Zhenyu; Dagle, Jeffery E.

2008-07-31

The infrastructure of phasor measurements have evolved over the last two decades from isolated measurement units to networked measurement systems with footprints beyond individual utility companies. This is, to a great extent, a bottom-up self-evolving process except some local systems built by design. Given the number of phasor measurement units (PMUs) in the system is small (currently 70 each in western and eastern interconnections), current phasor network architecture works just fine. However, the architecture will become a bottleneck when large number of PMUs are installed (e.g. >1000~10000). The need for phasor architecture design has yet to be addressed. This papermore » reviews the current phasor networks and investigates future architectures, as related to the efforts undertaken by the North America SynchroPhasor Initiative (NASPI). Then it continues to present staged system tests to evaluate the performance of phasor networks, which is a common practice in the Western Electricity Coordinating Council (WECC) system. This is followed by field measurement evaluation and the implication of phasor quality issues on phasor applications.« less

One output function: a misconception of students studying digital systems - a case study

NASA Astrophysics Data System (ADS)

Trotskovsky, E.; Sabag, N.

2015-05-01

Background:Learning processes are usually characterized by students' misunderstandings and misconceptions. Engineering educators intend to help their students overcome their misconceptions and achieve correct understanding of the concept. This paper describes a misconception in digital systems held by many students who believe that combinational logic circuits should have only one output. Purpose:The current study aims to investigate the roots of the misconception about one-output function and the pedagogical methods that can help students overcome the misconception. Sample:Three hundred and eighty-one students in the Departments of Electrical and Electronics and Mechanical Engineering at an academic engineering college, who learned the same topics of a digital combinational system, participated in the research. Design and method:In the initial research stage, students were taught according to traditional method - first to design a one-output combinational logic system, and then to implement a system with a number of output functions. In the main stage, an experimental group was taught using a new method whereby they were shown how to implement a system with several output functions, prior to learning about one-output systems. A control group was taught using the traditional method. In the replication stage (the third stage), an experimental group was taught using the new method. A mixed research methodology was used to examine the results of the new learning method. Results:Quantitative research showed that the new teaching approach resulted in a statistically significant decrease in student errors, and qualitative research revealed students' erroneous thinking patterns. Conclusions:It can be assumed that the traditional teaching method generates an incorrect mental model of the one-output function among students. The new pedagogical approach prevented the creation of an erroneous mental model and helped students develop the correct conceptual understanding.

Dynamics of the Final Stages of Terrestrial Planet Growth and the Formation of the Earth-Moon System

NASA Technical Reports Server (NTRS)

Lissauer, Jack J.; Rivera, Eugenio J.; DeVincenzi, Donald (Technical Monitor)

2000-01-01

An overview of current theories of star and planet formation, with emphasis on terrestrial planet accretion and the formation of the Earth-Moon system is presented. These models predict that rocky planets should form around most single stars, although it is possible that in some cases such planets are lost to orbital decay within the protoplanetary disk. The frequency of formation of gas giant planets is more difficult to predict theoretically. Terrestrial planets are believed to grow via pairwise accretion until the spacing of planetary orbits becomes large enough that the configuration is stable for the age of the system. Giant impacts during the final stages of growth can produce large planetary satellites, such as Earth's Moon. Giant planets begin their growth like terrestrial planets, but they become massive enough that they are able to accumulate substantial amounts of gas before the protoplanetary disk dissipates.

250 kV 6 mA compact Cockcroft-Walton high-voltage power supply.

PubMed

Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

2016-08-01

A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Zhan-Wen; Su, Xiao-Dong; Wei, Zhen

A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of themore » output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.« less

Ablation Modeling of Ares-I Upper State Thermal Protection System Using Thermal Desktop

NASA Technical Reports Server (NTRS)

Sharp, John R.; Page, Arthur T.

2007-01-01

The thermal protection system (TPS) for the Ares-I Upper Stage will be based on Space Transportation System External Tank (ET) and Solid Rocket Booster (SRB) heritage materials. These TPS materials were qualified via hot gas testing that simulated ascent and re-entry aerothermodynamic convective heating environments. From this data, the recession rates due to ablation were characterized and used in thermal modeling for sizing the thickness required to maintain structural substrate temperatures. At Marshall Space Flight Center (MSFC), the in-house code ABL is currently used to predict TPS ablation and substrate temperatures as a FORTRAN application integrated within SINDA/G. This paper describes a comparison of the new ablation utility in Thermal Desktop and SINDA/FLUINT with the heritage ABL code and empirical test data which serves as the validation of the Thermal Desktop software for use on the design of the Ares-I Upper Stage project.

System-level change in mental health services in North Wales: An observational study using systems thinking.

PubMed

Evans, S; Huxley, P J; Maxwell, N; Huxley, K L S

2014-06-01

To describe changes to mental health services using systems thinking. Structured standardized quality of life assessment (Manchester Short Quality of Life Assessment: MANSA) was used to establish service user priorities for changes to service provision (part of a process known as check in systems thinking). Current service performance in these priority areas was identified, and changes to service arrangements were planned, implemented and monitored by task and finish (T&F) groups (making use of a process known as flow in systems thinking). 81 MANSA assessments were completed at the check stage (by NM). Work finances and leisure activities emerged as service user priority areas for change, and T&F groups were established with representation of all sectors and service users. Ways to make improvements were observed, planned and implemented by T&F groups (the flow stage). The systems approach reveals how services and quality of life have been changed for patients in Wrexham. Further generalizable research is needed into the potential benefits of using systems thinking in mental health service evaluation. © The Author(s) 2013.

Flood inundation maps for the Wabash River at New Harmony, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.

2016-10-11

Digital flood-inundation maps for a 3.68-mile reach of the Wabash River extending 1.77 miles upstream and 1.91 miles downstream from streamgage 03378500 at New Harmony, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Wabash River at New Harmony, Ind. (station 03378500). Near-real-time stages at this streamgage may be obtained from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http://water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NHRI3).Flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was calibrated by using the most current stage-discharge relations at the Wabash River at New Harmony, Ind., streamgage and the documented high-water marks from the flood of April 27–28, 2013. The calibrated hydraulic model was then used to compute 17 water-surface profiles for flood stages at approximately 1-foot intervals referenced to the streamgage datum and ranging from 10.0 feet, or near bankfull, to 25.4 feet, the highest stage of the stage-discharge rating curve used in the model. The simulated water-surface profiles were then combined with a geographic information system digital elevation model (derived from light detection and ranging (lidar) data having a 0.98-ft vertical accuracy and 4.9-ft horizontal resolution) to delineate the area flooded at each water level.The availability of these maps along with Internet information regarding current stage from the USGS streamgage at Wabash River at New Harmony, Ind., and forecasted stream stages from the NWS will provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures, as well as for post-flood recovery efforts.

Overview of Lockheed Martin cryocoolers

NASA Astrophysics Data System (ADS)

Nast, T.; Olson, J.; Champagne, P.; Evtimov, B.; Frank, D.; Roth, E.; Renna, T.

2006-02-01

Lockheed Martin's Advanced Technology Center (LM-ATC) in Palo Alto, California, has been active in space cryogenic developments for over 30 years. In prior years, work focused on stored cryogen systems for temperatures up to 125 K. As the mechanical cryocoolers matured and demonstrated reliable operation these stored cryogen systems gradually became replaced. LM-ATC is currently developing solid hydrogen systems for temperatures below 7 K [Naes L, Wu S, Cannon J. WISE solid hydrogen cryostat design overview. In: Proceedings of SPIE, cryogenic optical systems and instruments XI, vol. 5904, August, 2005], but these coolers will soon be replaced by mechanical cryocoolers. This paper will present a summary of cryocooler developments at LM-ATC and will describe the recent performance of multiple stage systems. A four-stage pulse tube cryocooler developed under contract to the Jet Propulsion Laboratory (JPL) has been recently developed and operated at 3.8 K [Olson JR, Moore M, Champagne P, Roth E, Evtimov B, Jensen J, et al. Development of a space-type-4-stage pulse tube cryocooler for very low temperatures, Adv Cryogen Engr, vol. 50, Amer Inst of Physics, New York, in press]. Coolers with one, two and three stages have also been widely developed [Nast TC et al. Miniature pulse tube cryocooler for space applications. Cryocoolers, vol. 11. New York: Plenum Press; 2000. p. 145-54; Olson J et al. Development of a 10 K pulse tube cryocooler for space applications. In: Ross R, editor. Cryocoolers, vol. 12. New York: Kluwer Academic/Plenum Publishers; 2003. p. 241-6; Nast TC et al. Lockheed Martin two-stage pulse tube cryocooler for GIFTS. Cryocoolers, vol. 13. New York: Kluwer Academic/Plenum Publishers; 2005; Frank D et al. Lockheed Martin RAMOS engineering model cryocooler. Cryocoolers, vol. 13. New York: Kluwer Academic/Plenum Publishers; 2005]. A staging approach is required to achieve very low temperatures, and also provides cooling at warmer temperatures, which is invariably beneficial in reducing heat loads to the lower temperature stages, or for cooling other system components. For example, our two-stage cooler [Nast TC et al. Lockheed Martin two-stage pulse tube cryocooler for GIFTS. Cryocoolers, vol. 13. New York: Kluwer Academic/Plenum Publishers; 2005; Frank D et al. Lockheed Martin RAMOS engineering model cryocooler. Cryocoolers, vol. 13. New York: Kluwer Academic/Plenum Publishers; 2005] is used to cool a low-temperature focal plane as well as a higher temperature optical sensor, using a single compressor and electronics at a substantial benefit in weight, reliability and cost.

PD-L1 expression is associated with p16INK4A expression in non-oropharyngeal head and neck squamous cell carcinoma

PubMed Central

Chen, San-Chi; Chang, Peter Mu-Hsin; Wang, Hsiao-Jung; Tai, Shyh-Kuan; Chu, Pen-Yuan; Yang, Muh-Hwa

2018-01-01

PD-L1 expression is critical in helping tumor cells evade the immune system. However, the level of PD-L1 expression in non-oropharyngeal head and neck squamous cell carcinoma (non-OPHNSCC) and its association with patient prognosis remains unclear. A retrospective clinicopathological analysis was performed on 106 patients with non-OPHNSCC diagnosed between 2007 and 2014. In the current study, tissue arrays from paraffin-embedded non-OPHNSCC samples obtained from patients were constructed, and PD-L1 and p16INK4A expression were determined using immunohistochemistry. Systemic inflammatory factors, including C-reactive protein, serum white blood cell, neutrophil, monocyte and lymphocyte counts were also analyzed. The current study demonstrated that PD-L1 was overexpressed in 32.1% (34/106) and p16INK4A in 20.8% (22/106) of patients. The expression of PD-L1 was associated with p16INK4A expression (P<0.01) but was not associated with levels of systemic inflammatory factors. Tumor stage was determined to be a significant prognostic value (stage I/II vs. III/IV, P=0.03), however, PD-L1, p16INK4A or other clinicopathological factors were not. The current study identified an association between PD-L1 and p16INK4A expression in non-OPHNSCC. This may facilitate the development of anti-PD1/PDL1 therapies to treat patients with head and neck cancer. PMID:29434933

An Overview of NASA's Integrated Design and Engineering Analysis (IDEA) Environment

NASA Technical Reports Server (NTRS)

Robinson, Jeffrey S.

2011-01-01

Historically, the design of subsonic and supersonic aircraft has been divided into separate technical disciplines (such as propulsion, aerodynamics and structures), each of which performs design and analysis in relative isolation from others. This is possible, in most cases, either because the amount of interdisciplinary coupling is minimal, or because the interactions can be treated as linear. The design of hypersonic airbreathing vehicles, like NASA's X-43, is quite the opposite. Such systems are dominated by strong non-linear interactions between disciplines. The design of these systems demands that a multi-disciplinary approach be taken. Furthermore, increased analytical fidelity at the conceptual design phase is highly desirable, as many of the non-linearities are not captured by lower fidelity tools. Only when these systems are designed from a true multi-disciplinary perspective, can the real performance benefits be achieved and complete vehicle systems be fielded. Toward this end, the Vehicle Analysis Branch at NASA Langley Research Center has been developing the Integrated Design and Engineering Analysis (IDEA) Environment. IDEA is a collaborative environment for parametrically modeling conceptual and preliminary designs for launch vehicle and high speed atmospheric flight configurations using the Adaptive Modeling Language (AML) as the underlying framework. The environment integrates geometry, packaging, propulsion, trajectory, aerodynamics, aerothermodynamics, engine and airframe subsystem design, thermal and structural analysis, and vehicle closure into a generative, parametric, unified computational model where data is shared seamlessly between the different disciplines. Plans are also in place to incorporate life cycle analysis tools into the environment which will estimate vehicle operability, reliability and cost. IDEA is currently being funded by NASA?s Hypersonics Project, a part of the Fundamental Aeronautics Program within the Aeronautics Research Mission Directorate. The environment is currently focused around a two-stage-to-orbit configuration with a turbine-based combined cycle (TBCC) first stage and a reusable rocket second stage. IDEA will be rolled out in generations, with each successive generation providing a significant increase in capability, either through increased analytic fidelity, expansion of vehicle classes considered, or by the inclusion of advanced modeling techniques. This paper provides the motivation behind the current effort, an overview of the development of the IDEA environment (including the contents and capabilities to be included in Generation 1 and Generation 2), and a description of the current status and detail of future plans.

Relaxation of flux ropes and magnetic reconnection in the Reconnection Scaling Experiment at LANL

NASA Astrophysics Data System (ADS)

Furno, I.; Intrator, T.; Hemsing, E.; Hsu, S.; Lapenta, G.; Abbate, S.

2004-12-01

Magnetic reconnection and plasma relaxation are studied in the Reconnection Scaling Experiment (RSX) with current carrying plasma columns (magnetic flux ropes). Using plasma guns, multiple flux ropes (Bθ ≤ 100 Gauss, L=90 cm, r≤3 cm) are generated in a three-dimensional (3D) cylindrical geometry and are observed to evolve dynamically during the injection of magnetic helicity. Detailed evolution of electron density, temperature, plasma potential and magnetic field structures is reconstructed experimentally and visible light emission is captured with a fast-gated, intensified CCD camera to provide insight into the global flux rope dynamics. Experiments with two flux ropes in collisional plasmas and in a strong axial guide field (Bz / Bθ > 10) suggest that magnetic reconnection plays an important role in the initial stages of flux rope evolution. During the early stages of the applied current drive (t≤ 20 τ Alfv´ {e}n), the flux ropes are observed to twist, partially coalesce and form a thin current sheet with a scale size comparable to that of the ion sound gyro-radius. Here, non-ideal terms in a generalized Ohm's Law appear to play a significant role in the 3D reconnection process as shown by the presence of a strong axial pressure gradient in the current sheet. In addition, a density perturbation with a structure characteristic of a kinetic Alfvén wave is observed to propagate axially in the current layer, anti-parallel to the induced sheet current. Later in the evolution, when a sufficient amount of helicity is injected into the system, a critical threshold for the kink instability is exceeded and the helical twisting of each individual flux rope can dominate the dynamics of the system. This may prevent the complete coalescence of the flux ropes.

Relaxation of flux ropes and magnetic reconnection in the Reconnection Scaling Experiment at LANL

NASA Astrophysics Data System (ADS)

Furno, Ivo

2004-11-01

Magnetic reconnection and plasma relaxation are studied in the Reconnection Scaling Experiment (RSX) with current carrying plasma columns (magnetic flux ropes). Using plasma guns, multiple flux ropes (B_pol < 100 Gauss, L=90 cm, r < 3 cm) are generated in a three-dimensional (3D) cylindrical geometry and are observed to evolve dynamically during the injection of magnetic helicity. Detailed evolution of electron density, temperature, plasma potential and magnetic field structures is reconstructed experimentally and visible light emission is captured with a fast-gated, intensified CCD camera to provide insight into the global flux rope dynamics. Experiments with two flux ropes in collisional plasmas and in a strong axial guide field (Bz / B_pol > 10) suggest that magnetic reconnection plays an important role in the initial stages of flux rope evolution. During the early stages of the applied current drive (t < 20τ_Alfven), the flux ropes are observed to twist, partially coalesce and form a thin current sheet with a scale size comparable to that of the ion sound gyro-radius. Here, non-ideal terms in a generalized Ohm's Law appear to play a significant role in the 3D reconnection process as shown by the presence of a strong axial pressure gradient in the current sheet. In addition, a density perturbation with a structure characteristic of a kinetic Alfvén wave is observed to propagate axially in the current layer, anti-parallel to the induced sheet current. Later in the evolution, when a sufficient amount of helicity is injected into the system, a critical threshold for the kink instability is exceeded and the helical twisting of each individual flux rope can dominate the dynamics of the system. This may prevent the complete coalescence of the flux ropes.

Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems.

PubMed

Smelko, John Paul; Wiltberger, Kelly Rae; Hickman, Eric Francis; Morris, Beverly Janey; Blackburn, Tobias James; Ryll, Thomas

2011-01-01

The adoption of disposable bioreactor technology as an alternate to traditional nondisposable technology is gaining momentum in the biotechnology industry. Evaluation of current disposable bioreactors systems to sustain high intensity fed-batch mammalian cell culture processes needs to be explored. In this study, an assessment was performed comparing single-use bioreactors (SUBs) systems of 50-, 250-, and 1,000-L operating scales with traditional stainless steel (SS) and glass vessels using four distinct mammalian cell culture processes. This comparison focuses on expansion and production stage performance. The SUB performance was evaluated based on three main areas: operability, process scalability, and process performance. The process performance and operability aspects were assessed over time and product quality performance was compared at the day of harvest. Expansion stage results showed disposable bioreactors mirror traditional bioreactors in terms of cellular growth and metabolism. Set-up and disposal times were dramatically reduced using the SUB systems when compared with traditional systems. Production stage runs for both Chinese hamster ovary and NS0 cell lines in the SUB system were able to model SS bioreactors runs at 100-, 200-, 2,000-, and 15,000-L scales. A single 1,000-L SUB run applying a high intensity fed-batch process was able to generate 7.5 kg of antibody with comparable product quality. Copyright © 2011 American Institute of Chemical Engineers (AIChE).

[Current wound care in patients with elephantiasis--third-stage lymphedema].

PubMed

Rucigaj, Tanja Planinsek; Slana, Ana; Leskovec, Nada Kecelj

2012-10-01

Lymphedema resulting from fluid accumulation due to impairment in the lymphatic system drainage leads to enlargement of the body part involved. If left untreated, in its third stage it results in elephantiasis. Elephantiasis is frequently accompanied by papillomatosis and lymphocutaneous fistulas with lymphorrhoea, erosions and ulcers, frequently with the loss of function in the respective part of the body. Unlike other chronic wounds, wound healing in lymphedema is highly dependent on the use of combined therapies because local treatment with modern supportive dressings and compression therapy with adhesive and non-adhesive short-stretch systems is only part of the complete treatment. This treatment also includes sub-bandage foamy materials, kinesitherapy with tapes (kinesiotaping), intermittent local application of high-pressure oxygen, breathing exercise, and manual lymph drainage and exercises.

Hyper-X Stage Separation Wind Tunnel Test Program

NASA Technical Reports Server (NTRS)

Woods, W. C.; Holland, S. D.; DiFulvio, M.

2000-01-01

NASA's Hyper-X research program was developed primarily to flight demonstrate a supersonic combustion ramjet engine, fully integrated with a forebody designed to tailor inlet flow conditions and a free expansion nozzle/afterbody to produce positive thrust at design flight conditions. With a point-designed propulsion system, the vehicle must depend upon some other means for boost to its design flight condition. Clean separation from this initial propulsion system stage within less than a second is critical to the success of the flight. This paper discusses the early planning activity, background, and chronology that developed the series of wind tunnel tests to support multi degree of freedom simulation of the separation process. Representative results from each series of tests are presented and issues and concerns during the process and current status will be highlighted.

Hyper-X Stage Separation Wind-Tunnel Test Program

NASA Technical Reports Server (NTRS)

Woods, William C.; Holland, Scott D.; DiFulvio, Michael

2001-01-01

NASA's Hyper-X research program was developed primarily to flight demonstrate a supersonic combustion ramjet engine, fully integrated with a forebody designed to tailor inlet flow conditions and a free expansion nozzle/afterbody to produce positive thrust at design flight conditions. With a point-designed propulsion system the vehicle must depend on some other means for boost to its design flight condition. Clean separation from this initial propulsion system stage within less than a second is critical to the success of the flight. This paper discusses the early planning activity, background, and chronology that developed the series of wind-tunnel tests to support multi-degree-of-freedom simulation of the separation process. Representative results from each series of tests are presented, and issues and concerns during the process and current status are highlighted.

Dynamic Properties of Electrotonic Coupling between Cells of Early Xenopus Embryos

PubMed Central

DiCaprio, R. A.; French, A. S.; Sanders, E. J.

1974-01-01

Frequency response functions were measured between the cells of Xenopus laevis embryos during the first two cleavage stages. Linear systems theory was then used to produce electronic models which account for the electrical behavior of the systems. Coupling between the cells may be explained by models which have simple resistive elements joining each cell to its neighbors. The vitelline, or fertilization, membrane which surrounds the embryos has no detectable resistance to the passage of electric current. The electrical properties of the four-cell embryo can only be explained by the existence of individual junctions linking each pair of cells. This arrangement suggests that electrotonic coupling is important in the development of the embryos, at least until the four-cell stage. ImagesFIGURE 5FIGURE 14FIGURE 15 PMID:19431351

Lessons drawn from 2 existing satellite networks: ARABSAT and EUTELSAT. Application to the Pacific basin projects

NASA Astrophysics Data System (ADS)

Bloch, Jean-Jacques

The Arabsat and Eutelsat systems are described. The Arabsat belongs to an organization which includes 20 countries of the Arab League. The Eutelsat belongs to the European telecommunication system which includes 29 countries, and is based op the Intelsat model. The current use of their payload is reviewed and compared with their respective planning stage predictions. From this perspective, some teachings are drawn which could be profitable for emerging region Pacific basin networks, now in the planning stage. In the Pacific basin several private and governmental regional satellite networks either newly existing or in the design phase are vying to deliver services to potential customers. These services include national television, commercial television, VSAT (Very Small Aperture Terminal) networks, and regional or domestic telephony.

Indonesia [Population education in countries of the region].

PubMed

Hardjosawarmono, S

1982-06-01

Indonesia currently faces 5 population problems: 1) large total population, estimated by 1980 census data at 147,383,075; 2) rapid population growth, increasing at the rate of 2.8 million annually by 1980; 3) a young population distribution, with 44% of the population under age 15; 4) uneven population distribution; and 5) rapid urbanization. The National Family Planning Coordinating Board (NFPCB), established in 1970 to plan and control family planning and population education, has set the goal of reducing the 1971 fertility rate by 50% by 1990. Population education is aimed at achieving voluntary acceptance of the small family idea. This is to be attained through awareness of the factors causing rapid population growth and the close interaction between such growth and development programs to enhance the standard of living. The population education program, which is administered by the Department of Education and Culture in cooperation with the NFPCB, underwent an orientation stage in 1970-72 and a pilot project stage in 1973-75. In the latter stage, teaching materials were developed and tested in 30 junior high schools. During the institutionalization stage, 1976-79, the program was systematically integrated into the educational system. Population topics are integrated with relevant subject areas from the 4th grade of elementary school to the 3rd grade of senior high school. A cell system is used to train teachers, who in turn train teachers in their respective schools. Population education has also been introduced into Indonesia's subsidiary schools under religious and Armed Forces jurisdiction. Current population education activities include the training of an additional 50,000 teachers and provision of teaching kits, slide projectors, and textbooks to all of the 160 nonformal learning centers. In addition, a number of government agencies, including the Ministries of Sports and Culture, Education, Health, Transmigration, Information, Religious Affairs, Home Affairs, and Defense, are involved in education programs aimed at those ages 10-45 who are outside of the educational system.

Steroid hormones, stress and the adolescent brain: a comparative perspective.

PubMed

Brown, G R; Spencer, K A

2013-09-26

Steroid hormones, including those produced by the gonads and the adrenal glands, are known to influence brain development during sensitive periods of life. Until recently, most brain organisation was assumed to take place during early stages of development, with relatively little neurogenesis or brain re-organisation during later stages. However, an increasing body of research has shown that the developing brain is also sensitive to steroid hormone exposure during adolescence (broadly defined as the period from nutritional independence to sexual maturity). In this review, we examine how steroid hormones that are produced by the gonads and adrenal glands vary across the lifespan in a range of mammalian and bird species, and we summarise the evidence that steroid hormone exposure influences behavioural and brain development during early stages of life and during adolescence in these two taxonomic groups. Taking a cross-species, comparative perspective reveals that the effects of early exposure to steroid hormones depend upon the stage of development at birth or hatching, as measured along the altricial-precocial dimension. We then review the evidence that exposure to stress during adolescence impacts upon the developing neuroendocrine systems, the brain and behaviour. Current research suggests that the effects of adolescent stress vary depending upon the sex of the individual and type of stressor, and the effects of stress could involve several neural systems, including the serotonergic and dopaminergic systems. Experience of stressors during adolescence could also influence brain development via the close interactions between the stress hormone and gonadal hormone axes. While sensitivity of the brain to steroid hormones during early life and adolescence potentially leaves the developing organism vulnerable to external adversities, developmental plasticity also provides an opportunity for the developing organism to respond to current circumstances and for behavioural responses to influence the future life history of the individual. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

System for quantifying the formation stages of corneal arcus

NASA Astrophysics Data System (ADS)

Nasution, Aulia; Fahdarina, Sally; Cahya, Deny I.

2015-07-01

Extensive research on interpreting the clinical signs of corneal-arcus formation and their related diagnostics potentials have found that there is a strong correlation of the arcus formation with the risk of coronary artery diseases and lipid stratification. Clinically the stages of the arcus formation are normally observed as separate grey-whitish arcs, that are formed at the inferior and then at the superior poles of the cornea. These arcs will by time being elongated to form a ring approximately 1 mm in width. In this paper, efforts to develop quantification system that is capable to recognize the stages of the arcus formation will be reported. The quantification was based on eye-images taken using prior developed low-cost digital image acquisition system, which self constructed from a plastic safety welding-goggle that was modified by placing two Logitec C525 webcam and LEDs lighting system. Pattern images of arcs with variation of arc's positions, lengths and thickness were used for pre-calibration purposes. Then these similar arcs are drawn on the of periphery of cornea images to simulate dummy corneal arcus, which mimick the stages of corneal arcus development. Using 672 data images, results of recognition show a good recognition rate, i.e. 93.6 % for determining arc's length (with maximum %RSD of 5.67 %) and 84.83 % for determining arc's thickness (with maximum %RSD of 5.67 %). Worser precision data were observed to happen for the small arc's length as well as small arc's thickness. Current efforts are devoted to translate the system for clinical trials.

What Is the Ideal Tumor Regression Grading System in Rectal Cancer Patients after Preoperative Chemoradiotherapy?

PubMed Central

Kim, Soo Hee; Chang, Hee Jin; Kim, Dae Yong; Park, Ji Won; Baek, Ji Yeon; Kim, Sun Young; Park, Sung Chan; Oh, Jae Hwan; Yu, Ami; Nam, Byung-Ho

2016-01-01

Purpose Tumor regression grade (TRG) is predictive of therapeutic response in rectal cancer patients after chemoradiotherapy (CRT) followed by curative resection. However, various TRG systems have been suggested, with subjective categorization, resulting in interobserver variability. This study compared the prognostic validity of four different TRG systems in order to identify the most ideal TRG system. Materials and Methods This study included 933 patients who underwent preoperative CRT and curative resection. Primary tumors alone were graded according to the American Joint Committee on Cancer (AJCC), Dworak, and Ryan TRG systems, and both primary tumors and regional lymph nodes were graded according to a modified Dworak TRG system. The ability of each TRG system to predict recurrence-free survival (RFS) and overall survival (OS) was analyzed using chi-square and C statistics. Results All four TRG systems were significantly predictive of both RFS and OS (p < 0.001 each), however none was a better predictor of prognosis than ypStage. Among the four TRGs, the mDworak TRG system was a better predictor of RFS and OS than the AJCC, Dworak, and Ryan TRG systems, and both the chi-square and C statistics were higher for the former, although the differences were not statistically significant. The combination of ypStage and the modified Dworak TRG better predicted RFS and OS than ypStage alone. Conclusion The modified Dworak TRG system for evaluation of entire tumors including regional lymph nodes is a better predictor of survival than current TRG systems for evaluation of the primary tumor alone. PMID:26511803

Catheter interventions in the staged management of hypoplastic left heart syndrome.

PubMed

Reinhardt, Zdenka; De Giovanni, Joseph; Stickley, John; Bhole, Vinay K; Anderson, Benjamin; Murtuza, Bari; Mehta, Chetan; Miller, Paul; Dhillon, Rami; Stumper, Oliver

2014-04-01

To analyse the current practice and contribution of catheter interventions in the staged management of patients with hypoplastic left heart syndrome. This study is a retrospective case note review of 527 patients undergoing staged Norwood/Fontan palliation at a single centre between 1993 and 2010. Indications and type of catheter interventions were reviewed over a median follow-up period of 7.5 years. A staged Norwood/Fontan palliation for hypoplastic left heart syndrome was performed in 527 patients. The 30-day survival rate after individual stages was 76.5% at Stage I, 96.3% at Stage II, and 99.4% at Stage III. A total of 348 interventions were performed in 189 out of 527 patients. Freedom from catheter intervention in survivors was 58.2% before Stage II and 46.7% before Stage III. Kaplan-Meier freedom from intervention post Fontan completion was 55% at 10.8 years of follow-up. Post-stage I interventions were mostly directed to relieve aortic arch obstruction--84 balloon angioplasties--and augment pulmonary blood flow--15 right ventricle-to-pulmonary conduit interventions; post-Stage II interventions centred on augmenting size of the left pulmonary artery--73 procedures and abolishing systemic venous collaterals--32 procedures. After Stage III, the focus was on manipulating the size of the fenestration--42 interventions--and the left pulmonary artery -31 procedures. Interventional cardiac catheterisation constitutes an integral part in the staged palliative management of patients with hypoplastic left heart syndrome. Over one-third (37%) of patients undergoing staged palliation required catheter intervention over the follow-up period.

Outside-the-(Cavity-prep)-Box Thinking

PubMed Central

Thompson, V.P.; Watson, T.F.; Marshall, G.W.; Blackman, B.R.K.; Stansbury, J.W.; Schadler, L.S.; Pearson, R.A.; Libanori, R.

2013-01-01

Direct placement restorative materials must interface with tooth structures that are often compromised by caries or trauma. The material must seal the interface while providing sufficient strength and wear resistance to assure function of the tooth for, ideally, the lifetime of the patient. Needed are direct restorative materials that are less technique-sensitive than current resin-based composite systems while having improved properties. The ideal material could be successfully used in areas of the world with limited infrastructure. Advances in our understanding of the interface between the restoration adhesive system and the stages of carious dentin can be used to promote remineralization. Application of fracture mechanics to adhesion at the tooth-restoration interface can provide insights for improvement. Research in polymer systems suggests alternatives to current composite resin matrix systems to overcome technique sensitivity, while advances in nano- and mesoparticle reinforcement and alignment in composite systems can increase material strength, toughness, and wear resistance, foreshadowing dental application. PMID:24129814

Recommendation System for Adaptive Learning.

PubMed

Chen, Yunxiao; Li, Xiaoou; Liu, Jingchen; Ying, Zhiliang

2018-01-01

An adaptive learning system aims at providing instruction tailored to the current status of a learner, differing from the traditional classroom experience. The latest advances in technology make adaptive learning possible, which has the potential to provide students with high-quality learning benefit at a low cost. A key component of an adaptive learning system is a recommendation system, which recommends the next material (video lectures, practices, and so on, on different skills) to the learner, based on the psychometric assessment results and possibly other individual characteristics. An important question then follows: How should recommendations be made? To answer this question, a mathematical framework is proposed that characterizes the recommendation process as a Markov decision problem, for which decisions are made based on the current knowledge of the learner and that of the learning materials. In particular, two plain vanilla systems are introduced, for which the optimal recommendation at each stage can be obtained analytically.

Technology Overview and Assessment for Small-Scale EDL Systems

NASA Technical Reports Server (NTRS)

Heidrich, Casey R.; Smith, Brandon P.; Braun, Robert D.

2016-01-01

Motivated by missions to land large rovers and humans at Mars and other bodies, high-mass EDL technologies are a prevalent trend in the research community. In contrast, EDL systems for low-mass payloads have attracted less attention. Significant potential in science and discovery exists in small-scale EDL systems. Payloads acting secondary to a flagship mission are a currently under-utilzed resource. Before taking advantage of these opportunities, further developed of scaled EDL technologies is required. The key limitations identified in this study are compact decelerators and deformable impact systems. Current technologies may enable rough landing of small payloads, with moderate restrictions in packaging volume. Utilization of passive descent and landing stages will greatly increase the applicability of small systems, allowing for vehicles robust to entry environment uncertainties. These architectures will provide an efficient means of achieving science and support objectives while reducing cost and risk margins of a parent mission.

Role of Chemotherapy and Targeted Therapy in Early-Stage Non-Small Cell Lung Cancer.

PubMed

Gadgeel, Shirish M

2017-01-01

On the basis of several randomized trials and meta-analyses, adjuvant chemotherapy is the accepted standard of care for certain patients with early-stage non-small cell lung cancer (NSCLC). Patients with stage II, IIIA, or large (≥ 4 cm) IB tumors are candidates for adjuvant chemotherapy. The survival improvement with adjuvant chemotherapy is approximately 5% at 5 years, though certain trials have suggested that it can be 8% to 10%. Neoadjuvant chemotherapy also has shown a survival advantage, though the volume of data with this approach is far less than that of adjuvant chemotherapy. The combination of cisplatin and vinorelbine is the most well-studied regimen, but current consensus is to use four cycles of any of the platinum-based chemotherapy regimens commonly used as front-line therapy for patients with advanced-stage NSCLC. Trials to define biomarkers that can predict benefit from adjuvant chemotherapy have not been successful, but results of other such trials are still awaited. On the basis of the benefit observed with targeted agents in patients with advanced-stage disease and driver genetic alterations in their tumors, ongoing trials are evaluating the utility of these targeted agents as adjuvant therapy. Similarly, clinical benefit observed with checkpoint inhibitors has prompted assessment of these drugs in patients with early-stage NSCLC. It is very likely, in the future, that factors other than the anatomy of the tumor will be used to select patients with early-stage NSCLC for systemic therapy and that the choice of systemic therapy will extend beyond platinum-based chemotherapy.

Psychosocial treatments for schizophrenia.

PubMed

Mueser, Kim T; Deavers, Frances; Penn, David L; Cassisi, Jeffrey E

2013-01-01

The current state of the literature regarding psychosocial treatments for schizophrenia is reviewed within the frameworks of the recovery model of mental health and the expanded stress-vulnerability model. Interventions targeting specific domains of functioning, age groups, stages of illness, and human service system gaps are classified as evidence-based practices or promising practices according to the extent to which their efficacy is currently supported by meta-analyses and individual randomized controlled trials (RCTs). Evidence-based practices include assertive community treatment (ACT), cognitive behavior therapy (CBT) for psychosis, cognitive remediation, family psychoeducation, illness self-management training, social skills training, and supported employment. Promising practices include cognitive adaptive therapy, CBT for posttraumatic stress disorder, first-episode psychosis intervention, healthy lifestyle interventions, integrated treatment for co-occurring disorders, interventions targeting older individuals, peer support services, physical disease management, prodromal stage intervention, social cognition training, supported education, and supported housing. Implications and future directions are discussed.

Status, Plans and Initial Results for Ares I Crew Launch Vehicle Aerodynamics

NASA Technical Reports Server (NTRS)

Huebner, Lawrence D.; Hall, Robert M.; Haynes, Davy A.; Pamadi, Bandu N.; Taylor, Terry L.; Seaford, C. Mark

2008-01-01

Following the completion of NASA s Exploration Systems Architecture Study in August 2004 for the NASA Exploration Systems Mission Directorate (ESMD), the Ares Projects Office at the NASA Marshall Space Flight Center was assigned project management responsibilities for the design and development of the first vehicle in the architecture, the Ares I Crew Launch Vehicle (CLV), which will be used to launch astronauts to low earth orbit and rendezvous with either the International Space Station or the ESMD s earth departure stage for lunar or other future missions beyond low Earth orbit. The primary elements of the Ares I CLV project are the first stage, the upper stage, the upper stage engine, and vehicle integration. Within vehicle integration is an effort in integrated design and analysis which is comprised of a number of technical disciplines needed to support vehicle design and development. One of the important disciplines throughout the life of the project is aerodynamics. This paper will present the status, plans, and initial results of Ares I CLV aerodynamics as the project was preparing for the Ares I CLV Systems Requirements Review. Following a discussion of the specific interactions with other technical panels and a status of the current activities, the plans for aerodynamic support of the Ares I CLV until the initial crewed flights will be presented. Keywords: Ares I Crew Launch Vehicle, aerodynamics, wind tunnel testing, computational fluid dynamics

Consumer effects on the vital rates of their resource can determine the outcome of competition between consumers.

PubMed

Lee, Charlotte T; Miller, Tom E X; Inouye, Brian D

2011-10-01

Current competition theory does not adequately address the fact that competitors may affect the survival, growth, and reproductive rates of their resources. Ecologically important interactions in which consumers affect resource vital rates range from parasitism and herbivory to mutualism. We present a general model of competition that explicitly includes consumer-dependent resource vital rates. We build on the classic MacArthur model of competition for multiple resources, allowing direct comparison with expectations from established concepts of resource-use overlap. Consumers share a stage-structured resource population but may use the different stages to different extents, as they do the different independent resources in the classic model. Here, however, the stages are dynamically linked via consumer-dependent vital rates. We show that consumers' effects on resource vital rates result in two important departures from classic results. First, consumers can coexist despite identical use of resource stages, provided each competitor shifts the resource stage distribution toward stages that benefit other species. Second, consumers specializing on different resource stages can compete strongly, possibly resulting in competitive exclusion despite a lack of resource stage-use overlap. Our model framework demonstrates the critical role that consumer-dependent resource vital rates can play in competitive dynamics in a wide range of biological systems.

Implementation of a Single-Stage-To-Orbit (SSTO) model for stability and control analysis

NASA Astrophysics Data System (ADS)

Ingalls, Stephen A.

1995-07-01

Three NASA centers: Marshall Space Flight Center (MSFC), Langley Research Center (LaRC), and Johnson Space Center (JSC) are currently involved in studying a family of single-stage- and two-stage-to-orbit (SSTO/TSTO) vehicles to serve as the next generation space transportation system (STS). A rocketed winged-body is the current focus. The configuration (WB001) is a vertically-launched, horizontally-landing system with circular cross-section. Preliminary aerodynamic data was generated by LaRC and is a combination of wind-tunnel data, empirical methods, and Aerodynamic Preliminary Analysis System-(APAS) generated values. JSC's efforts involve descent trajectory design, stability analysis, and flight control system synthesis. Analysis of WB001's static stability indicates instability in 'tuck' (C(sub mu) less than 0: Mach = 0.30, alpha greater than 3.25 deg; Mach = 0.60, alpha greater than 8.04), an unstable dihedral effects (C(sub l(beta)) greater than 0: Mach = 30,alpha less than 12 deg.; Mach = 0.60, alpha less than 10.00 deg.), and, most significantly, an unstable weathercock stability derivative, C(sub n(beta)), at all angles of attack and subsonic Mach numbers. Longitudinal trim solutions for Mach = 0.30 and 0.60 indicate flight path angle possibilities ranging from around 12 (M = 0.30) to slightly over 20 degrees at Mach = 0.60. Trim angles of attack increase from 6.24 at Mach 0.60 and 10,000 feet to 17.7 deg. at Mach 0.30, sea-level. Lateral trim was attempted for a design cross-wind of 25.0 knots. The current vehicle aerodynamic and geometric characteristics will only yield a lateral trim solution at impractical tip-fin deflections (approximately equal to 43 deg.) and bank angles (21 deg.). A study of the lateral control surfaces, tip-fin controllers for WB001, indicate increased surface area would help address these instabilities, particularly the deficiency in C(sub n(beta)), but obviously at the expense of increased vehicle weight. Growth factors of approximately 7 were determined using a design C(sub n(beta)) of 0.100/radian (approximate subsonic values for the orbiter).

NASA's Space Launch System: A Transformative Capability for Deep Space Missions

NASA Technical Reports Server (NTRS)

Creech, Stephen D.

2017-01-01

Already making substantial progress toward its first launches, NASA’s Space Launch System (SLS) exploration-class launch vehicle presents game-changing new opportunities in spaceflight, enabling human exploration of deep space, as well as a variety of missions and mission profiles that are currently impossible. Today, the initial configuration of SLS, able to deliver more than 70 metric tons of payload to low Earth orbit (LEO), is well into final production and testing ahead of its planned first flight, which will send NASA’s new Orion crew vehicle around the moon and will deploy 13 CubeSats, representing multiple disciplines, into deep space. At the same time, production work is already underway toward the more-capable Block 1B configuration, planned to debut on the second flight of SLS, and capable of lofting 105 tons to LEO or of co-manifesting large exploration systems with Orion on launches to the lunar vicinity. Progress being made on the vehicle for that second flight includes initial welding of its core stage and testing of one of its engines, as well as development of new elements such as the powerful Exploration Upper Stage and the Universal Stage Adapter “payload bay.” Ultimately, SLS will evolve to a configuration capable of delivering more than 130 tons to LEO to support humans missions to Mars. In order to enable human deep-space exploration, SLS provides unrivaled mass, volume, and departure energy for payloads, offering numerous benefits for a variety of other missions. For robotic science probes to the outer solar system, for example, SLS can cut transit times to less than half that of currently available vehicles or substantially increased spacecraft mass. In the field of astrophysics, SLS’ high payload volume, in the form of payload fairings with a diameter of up to 10 meters, creates the opportunity for launch of large-aperture telescopes providing an unprecedented look at our universe. This presentation will give an overview of SLS’ capabilities and its current status, and discuss the vehicle’s potential for human exploration of deep space and other game-changing utilization opportunities.

Molecular Physiology of Root System Architecture in Model Grasses

NASA Astrophysics Data System (ADS)

Hixson, K.; Ahkami, A. H.; Anderton, C.; Veličković, D.; Myers, G. L.; Chrisler, W.; Lindenmaier, R.; Fang, Y.; Yabusaki, S.; Rosnow, J. J.; Farris, Y.; Khan, N. E.; Bernstein, H. C.; Jansson, C.

2017-12-01

Unraveling the molecular and physiological mechanisms involved in responses of Root System Architecture (RSA) to abiotic stresses and shifts in microbiome structure is critical to understand and engineer plant-microbe-soil interactions in the rhizosphere. In this study, accessions of Brachypodium distachyon Bd21 (C3 model grass) and Setaria viridis A10.1 (C4 model grass) were grown in phytotron chambers under current and elevated CO2 levels. Detailed growth stage-based phenotypic analysis revealed different above- and below-ground morphological and physiological responses in C3 and C4 grasses to enhanced CO2 levels. Based on our preliminary results and by screening values of total biomass, water use efficiency, root to shoot ratio, RSA parameters and net assimilation rates, we postulated a three-phase physiological mechanism, i.e. RootPlus, BiomassPlus and YieldPlus phases, for grass growth under elevated CO2 conditions. Moreover, this comprehensive set of morphological and process-based observations are currently in use to develop, test, and calibrate biophysical whole-plant models and in particular to simulate leaf-level photosynthesis at various developmental stages of C3 and C4 using the model BioCro. To further link the observed phenotypic traits at the organismal level to tissue and molecular levels, and to spatially resolve the origin and fate of key metabolites involved in primary carbohydrate metabolism in different root sections, we complement root phenotypic observations with spatial metabolomics data using mass spectrometry imaging (MSI) methods. Focusing on plant-microbe interactions in the rhizosphere, six bacterial strains with plant growth promoting features are currently in use in both gel-based and soil systems to screen root growth and development in Brachypodium. Using confocal microscopy, GFP-tagged bacterial systems are utilized to study the initiation of different root types of RSA, including primary root (PR), coleoptile node axile root (CNR) and leaf node axile root (LNR) during developmental stages of root formation. The root exudates also will be quantified and preliminary data will be used to engineer our microbial consortium to improve plant growth.

Implementation of a Single-Stage-To-Orbit (SSTO) model for stability and control analysis

NASA Technical Reports Server (NTRS)

Ingalls, Stephen A.

1995-01-01

Three NASA centers: Marshall Space Flight Center (MSFC), Langley Research Center (LaRC), and Johnson Space Center (JSC) are currently involved in studying a family of single-stage- and two-stage-to-orbit (SSTO/TSTO) vehicles to serve as the next generation space transportation system (STS). A rocketed winged-body is the current focus. The configuration (WB001) is a vertically-launched, horizontally-landing system with circular cross-section. Preliminary aerodynamic data was generated by LaRC and is a combination of wind-tunnel data, empirical methods, and Aerodynamic Preliminary Analysis System-(APAS) generated values. JSC's efforts involve descent trajectory design, stability analysis, and flight control system synthesis. Analysis of WB001's static stability indicates instability in 'tuck' (C(sub mu) less than 0: Mach = 0.30, alpha greater than 3.25 deg; Mach = 0.60, alpha greater than 8.04), an unstable dihedral effects (C(sub l(beta)) greater than 0: Mach = 30,alpha less than 12 deg.; Mach = 0.60, alpha less than 10.00 deg.), and, most significantly, an unstable weathercock stability derivative, C(sub n(beta)), at all angles of attack and subsonic Mach numbers. Longitudinal trim solutions for Mach = 0.30 and 0.60 indicate flight path angle possibilities ranging from around 12 (M = 0.30) to slightly over 20 degrees at Mach = 0.60. Trim angles of attack increase from 6.24 at Mach 0.60 and 10,000 feet to 17.7 deg. at Mach 0.30, sea-level. Lateral trim was attempted for a design cross-wind of 25.0 knots. The current vehicle aerodynamic and geometric characteristics will only yield a lateral trim solution at impractical tip-fin deflections (approximately equal to 43 deg.) and bank angles (21 deg.). A study of the lateral control surfaces, tip-fin controllers for WB001, indicate increased surface area would help address these instabilities, particularly the deficiency in C(sub n(beta)), but obviously at the expense of increased vehicle weight. Growth factors of approximately 7 were determined using a design C(sub n(beta)) of 0.100/radian (approximate subsonic values for the orbiter).

A pen-based system to support pre-operative data collection within an anaesthesia department.

PubMed Central

Sanz, M. F.; Gómez, E. J.; Trueba, I.; Cano, P.; Arredondo, M. T.; del Pozo, F.

1993-01-01

This paper describes the design and implementation of a pen-based computer system for remote preoperative data collection. The system is envisaged to be used by anaesthesia staff at different hospital scenarios where pre-operative data are generated. Pen-based technology offers important advantages in terms of portability and human-computer interaction, as direct manipulation interfaces by direct pointing, and "notebook user interfaces metaphors". Being the human factors analysis and user interface design a vital stage to achieve the appropriate user acceptability, a methodology that integrates the "usability" evaluation from the earlier development stages was used. Additionally, the selection of a pen-based computer system as a portable device to be used by health care personnel allows to evaluate the appropriateness of this new technology for remote data collection within the hospital environment. The work presented is currently being realised under the Research Project "TANIT: Telematics in Anaesthesia and Intensive Care", within the "A.I.M.--Telematics in Health CARE" European Research Program. PMID:8130488

Technology demonstration for reusable launchers

NASA Astrophysics Data System (ADS)

Baiocco, P.; Bonnal, Ch.

2016-03-01

Reusable launchers have been studied under CNES contracts for more than 30 years, with early concepts such as STS-2000 or Oriflamme, more recently with very significant efforts devoted to Liquid Fly Back Boosters as with the Bargouzin project led with Tsniimash, TSTO with the Everest concept studied by Airbus-DS as prime contractor or the RFS Reusable First Stage concept of a large first stage associated to a cryotechnic second stage. These investigations, summarized in the first part of the paper, enabled CNES to identify clearly the technology requirements associated to reusability, as well as cost efficiency through detailed non-recurring costs and mission costs analysis. In parallel, CNES set in place development logic for sub-systems and equipment based on demonstrators, hardware test benches enabling maturation of technologies up to a TRL such that an actual development can be decided with limited risk. This philosophy has been applied so far to a large number of cases, such as TPTech and TPX for Hydrogen turbo pump, GGPX as demonstrator of innovative gas generator, HX demonstrator of modern cryotechnic upper stage with a dozen of different objectives (Thermal Protection, 20K Helium storage, measurements …). This virtuous approach, "learn as you test", is currently applied in the phased approach towards scaled down reusable booster stage, whose possibility to be used as first stage of a microlaunch vehicle is under investigation. The selected technologies allow paving the way towards reusable booster stages for Ariane 6 evolutions or main reusable stage for a further generation of heavy launchers. The paper describes the logic behind this project, together with the demonstration objectives set for the various sub-systems as well as operations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merchant, Bion J.

The Seismo-Hydroacoustic Data Acquisition System (SHDAS) is undergoing evaluation in preparation for its engineering, development, and deployment by the U.S Navy as an ocean bottom seismic monitoring system. At the current stage of development, the production digitizers are being evaluated to confirm their performance prior to packaging and assembly for deployment. The testing of the digitizers is being conducted at Delta Group Electronics, the digitizer fabricator, in San Diego, California, performed by Sandia National Laboratories with the assistance of Leidos and Delta Group Electronics.

Reforming Dutch substance abuse treatment services.

PubMed

Schippers, Gerard M; Schramade, Mark; Walburg, Jan A

2002-01-01

The Dutch substance abuse treatment system is in the middle of a major reorganization. The goal is to improve outcomes by redesigning all major primary treatment processes and by implementing a system of regular monitoring and feedback of clinical outcome data. The new program includes implementing standardized psychosocial behavior-oriented treatment modalities and a stepped-care patient placement algorithm in a core-shell organizational model. This article outlines the new program and presents its objectives, developmental stages, and current status.

Renal Dialysis and its Financing.

PubMed

Borelli, Marisa; Paul, David P; Skiba, Michaeline

2016-01-01

The incidence of end-stage renal disease (ESRD) and its associated comorbidities such as diabetes and hypertension continue to increase as the population ages. As most ESRD patients qualify for Medicare coverage, the U.S. government initiated reforms of the payment system for dialysis facilities in an effort to decrease expenditures associated with ESRD reimbursement. The effects of reduced reimbursement rates, bundled payment options, and quality incentives on the current dialysis system, including kidney dialysis units, physicians, and patients, are examined.

Closed Classrooms, High Mountains and Strange Lands: An Inquiry into Culture and Caring.

ERIC Educational Resources Information Center

Kraft, Richard J.

1992-01-01

The current closed classroom system of education is not sufficient in preparing students for real world life. Proposes that the wilderness, cross-cultural, and international settings are a very powerful learning environment in which life-changing experiences can and do occur. Presents the Outward Bound process and Adler's stage theory of…

Tuning Primary Learning Style for Children with Secondary Behavioral Patterns

ERIC Educational Resources Information Center

Mosharraf, Maedeh

2016-01-01

Personalization is one of the most expected features in the current educational systems. User modeling is supposed to be the first stage of this process, which may incorporate learning style as an important part of the model. Learning style, which is a non-stable characteristic in the case of children, differentiates students in learning…

Funding Early Childhood Education: The President's Plan for the Future and States' Current Actions

ERIC Educational Resources Information Center

Best, Jane; Cohen, Courtney

2013-01-01

Increased attention to proposed federal early childhood education (ECE) legislation has sparked a debate on what the future holds for state-funded ECE systems. This brief explores how the goal of universal preschool is being shaped by the federal agenda and examines state programs in various stages of development. President Obama's Preschool for…

Ontology for Life-Cycle Modeling of Electrical Distribution Systems: Model View Definition

DTIC Science & Technology

2013-06-01

building information models ( BIM ) at the coordinated design stage of building construction. 1.3 Approach To...standard for exchanging Building Information Modeling ( BIM ) data, which defines hundreds of classes for common use in software, currently supported by...specifications, Construction Operations Building in- formation exchange (COBie), Building Information Modeling ( BIM ) 16. SECURITY CLASSIFICATION OF:

Staff supervision in residential care.

PubMed

Myers, Peter G; Bibbs, Tonya; Orozco, Candy

2004-04-01

Residential care workers must be offered opportunities for formalized and systematic supervision in individual and group formats to provide the highest possible level of care to children and adolescents whom they serve. Effective supervision with residential care staff should be open to exploring issues at all levels of their experience and in relation to each component of the broader organizational structure within which they work. Systems theory offers a useful lens through which to view supervising staff in residential treatment. Systems theory proposes that human behavior is shaped by interactional processes and internal factors. Although the development of the individual occurs within intrinsic cognitive and emotional spheres, it also is believed to be related to several other elements. These additional variables include the point at which the family and system function in their own life cycle, the historical and current emotional context, the current and changing structure of the system, narratives, and the cultural context. This article discussed how methods of training and supervision would be most effective if they were designed specifically for the developmental level of the participants. Some literature reviews have concluded that youth care workers, like all professionals, pass through developmental stages and progress through them in their work. To assist youth care workers in their jobs, supervisors must understand these stages and the ways in which they may be enacted in the workplace.

Powered Explicit Guidance Modifications and Enhancements for Space Launch System Block-1 and Block-1B Vehicles

NASA Technical Reports Server (NTRS)

Von der Porten, Paul; Ahmad, Naeem; Hawkins, Matt; Fill, Thomas

2018-01-01

NASA is currently building the Space Launch System (SLS) Block-1 launch vehicle for the Exploration Mission 1 (EM-1) test flight. NASA is also currently designing the next evolution of SLS, the Block-1B. The Block-1 and Block-1B vehicles will use the Powered Explicit Guidance (PEG) algorithm (of Space Shuttle heritage) for closed loop guidance. To accommodate vehicle capabilities and design for future evolutions of SLS, modifications were made to PEG for Block-1 to handle multi-phase burns, provide PEG updated propulsion information, and react to a core stage engine out. In addition, due to the relatively low thrust-to-weight ratio of the Exploration Upper Stage (EUS) and EUS carrying out Lunar Vicinity and Earth Escape missions, certain enhancements to the Block-1 PEG algorithm are needed to perform Block-1B missions to account for long burn arcs and target translunar and hyperbolic orbits. This paper describes the design and implementation of modifications to the Block-1 PEG algorithm as compared to Space Shuttle. Furthermore, this paper illustrates challenges posed by the Block-1B vehicle and the required PEG enhancements. These improvements make PEG capable for use on the SLS Block-1B vehicle as part of the Guidance, Navigation, and Control (GN&C) System.

Mechanisms important to later stages of streamer system development

NASA Astrophysics Data System (ADS)

Lehtinen, N. G.; Carlson, B.; Kochkin, P.; Østgaard, N.

2017-12-01

Typical streamer modeling focuses on the propagation of the streamer head and thus neglects processes such as electron detachment, electron energy relaxation, and thermalization of the electron energy distribution. These mechanisms, however, may become important at later stages of streamer system development, in particular following streamer collisions. We present a model of a later-stage streamer system development which includes these processes. A linear analysis suggests that these processes under some conditions can lead to new effects, such as excitation of waves similar to striations in the positive column of a glow discharge. Such instabilities do not occur if these mechanisms are neglected under the same conditions, although previous modeling suggested existence of wave-like phenomena during the streamer propagation [Luque et al, 2016, doi:10.1002/2015JA022234]. In the sea-level pressure air, the obtained striation-like waves may manifest as very high frequency range (>10 MHz) oscillations in plasma parameters and may have been detected in the electrode current and electromagnetic radiation measurements during laboratory spark experiments. We discuss whether the longitudinal electric field in such waves can efficiently transfer energy to charged particles, because such a process may play a role in production of x-rays.

Computer-Aided Modeling and Analysis of Power Processing Systems (CAMAPPS). Phase 1: Users handbook

NASA Technical Reports Server (NTRS)

Kim, S.; Lee, J.; Cho, B. H.; Lee, F. C.

1986-01-01

The EASY5 macro component models developed for the spacecraft power system simulation are described. A brief explanation about how to use the macro components with the EASY5 Standard Components to build a specific system is given through an example. The macro components are ordered according to the following functional group: converter power stage models, compensator models, current-feedback models, constant frequency control models, load models, solar array models, and shunt regulator models. Major equations, a circuit model, and a program listing are provided for each macro component.

Base drive circuit for a four-terminal power Darlington

DOEpatents

Lee, Fred C.; Carter, Roy A.

1983-01-01

A high power switching circuit which utilizes a four-terminal Darlington transistor block to improve switching speed, particularly in rapid turn-off. Two independent reverse drive currents are utilized during turn off in order to expel the minority carriers of the Darlington pair at their own charge sweep-out rate. The reverse drive current may be provided by a current transformer, the secondary of which is tapped to the base terminal of the power stage of the Darlington block. In one application, the switching circuit is used in each power switching element in a chopper-inverter drive of an electric vehicle propulsion system.

Intra- and interobserver reliability of the Eaton classification for trapeziometacarpal arthritis: a systematic review.

PubMed

Berger, Aaron J; Momeni, Arash; Ladd, Amy L

2014-04-01

Trapeziometacarpal, or thumb carpometacarpal (CMC), arthritis is a common problem with a variety of treatment options. Although widely used, the Eaton radiographic staging system for CMC arthritis is of questionable clinical utility, as disease severity does not predictably correlate with symptoms or treatment recommendations. A possible reason for this is that the classification itself may not be reliable, but the literature on this has not, to our knowledge, been systematically reviewed. We therefore performed a systematic review to determine the intra- and interobserver reliability of the Eaton staging system. We systematically reviewed English-language studies published between 1973 and 2013 to assess the degree of intra- and interobserver reliability of the Eaton classification for determining the stage of trapeziometacarpal joint arthritis and pantrapezial arthritis based on plain radiographic imaging. Search engines included: PubMed, Scopus(®), and CINAHL. Four studies, which included a total of 163 patients, met our inclusion criteria and were evaluated. The level of evidence of the studies included in this analysis was determined using the Oxford Centre for Evidence Based Medicine Levels of Evidence Classification by two independent observers. A limited number of studies have been performed to assess intra- and interobserver reliability of the Eaton classification system. The four studies included were determined to be Level 3b. These studies collectively indicate that the Eaton classification demonstrates poor to fair interobserver reliability (kappa values: 0.11-0.56) and fair to moderate intraobserver reliability (kappa values: 0.54-0.657). Review of the literature demonstrates that radiographs assist in the assessment of CMC joint disease, but there is not a reliable system for classification of disease severity. Currently, diagnosis and treatment of thumb CMC arthritis are based on the surgeon's qualitative assessment combining history, physical examination, and radiographic evaluation. Inconsistent agreement using the current common radiographic classification system suggests a need for better radiographic tools to quantify disease severity.

Flood-inundation maps for Suwanee Creek from the confluence of Ivy Creek to the Noblin Ridge Drive bridge, Gwinnett County, Georgia

USGS Publications Warehouse

Musser, Jonathan W.

2012-01-01

Digital flood-inundation maps for a 6.9-mile reach of Suwanee Creek, from the confluence of Ivy Creek to the Noblin Ridge Drive bridge, were developed by the U.S. Geological Survey (USGS) in cooperation with Gwinnett County, Georgia. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Suwanee Creek at Suwanee, Georgia (02334885). Current stage at this USGS streamgage may be obtained at http://waterdata.usgs.gov/ and can be used in conjunction with these maps to estimate near real-time areas of inundation. The National Weather Service (NWS) is incorporating results from this study into the Advanced Hydrologic Prediction Service (AHPS) flood-warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that commonly are collocated at USGS streamgages. The forecasted peak-stage information for the USGS streamgage at Suwanee Creek at Suwanee (02334885), available through the AHPS Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. A one-dimensional step-backwater model was developed using the U.S. Army Corps of Engineers HEC-RAS software for Suwanee Creek and was used to compute flood profiles for a 6.9-mile reach of the creek. The model was calibrated using the most current stage-discharge relations at the Suwanee Creek at Suwanee streamgage (02334885). The hydraulic model was then used to determine 19 water-surface profiles for flood stages at the Suwanee Creek streamgage at 0.5-foot intervals referenced to the streamgage. The profiles ranged from just above bankfull stage (7.0 feet) to approximately 1.7 feet above the highest recorded water level at the streamgage (16.0 feet). The simulated water-surface profiles were then combined with a geographic information system digital elevation model - derived from light detection and ranging (LiDAR) data having a 5.0-foot horizontal resolution - to delineate the area flooded for each 0.5-foot increment of stream stage. The availability of these maps, when combined with real-time stage information from USGS streamgages and forecasted stream stage from the NWS, provides emergency management personnel and residents with critical information during flood-response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

Progress Toward a Compact 0.05 K Magnet Refrigerator Operating from 10 K

NASA Technical Reports Server (NTRS)

Canavan, Edgar; Shirron, Peter; DiPirro, Micheal; Tuttle, James; Jackson, Michael; King, Todd; Numazawa, Takenori

2003-01-01

Much of the most interesting information regarding our universe is hidden in the sub-millimeter, infrared, and x-rays bands of the spectrum, to which our atmosphere is largely opaque. Thus, missions exploring these bands are a very important part of NASA s Space Science program. Coincidentally, the most sensitive detectors in these spectral regions operate at extremely low temperatures, typically 0.05 - 0.10 K. Generally these temperatures will be achieved using magnetic refrigerators, also know as Adiabatic Demagnetization Refrigerators, or ADRs. Current ADRs, such as the one used in the XRS-II instrument on the Astro-E2 satellite, use a single-stage to cool detectors from 1.3 K to 0.06 K. The ADR is designed so that it can absorb the heat on the detector stage for at least 24 hours before it must stop, warm up to the helium bath temperature (1.3 K), and dump the accumulated heat. Future detector arrays will be much larger and will have higher heat dissipation. Furthermore, future missions will use mechanical cryocoolers to provide upper stage cooling, but they can only reach 4 - 10 K. Trying to scale heavy (-15 kg) single stage ADRs up to the higher heat loads and higher heat rejection temperatures required leads to unacceptably large systems. The GSFC Cryogenics Branch has developed the Continuous ADR (CADR) to solve this problem. The CADR consists of a series of ADR stages that sequentially pass heat from the load up to the high temperature heat sink. The stage connected to the load remains at a constant temperature. The continuous stage effectively decouples detector operation from ADR operation, allowing the ADR stages to be cycled much more rapidly. Rapid cycling leads to higher cooling power density. The cascading, multistage arrangement allows the magnetic refrigerant of each stage to be optimized for its own temperature swing. In the past year, we have made good progress toward a 0.05 to 10K system. A four-stage system that operates from 4.2 K was demonstrated. Magnetic shielding was added to eliminate inter-stage coupling. Improvements were made to superconducting and passive gas-gap heat switches. A second type of passive gas gap switch, one meant for use at higher temperature, was demonstrated. The presentation will focus primarily on these recent design improvements, and on the challenges that remain on the progress toward a system that will operate from 10 K or higher.

Oil-free centrifugal hydrogen compression technology demonstration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heshmat, Hooshang

2014-05-31

One of the key elements in realizing a mature market for hydrogen vehicles is the deployment of a safe and efficient hydrogen production and delivery infrastructure on a scale that can compete economically with current fuels. The challenge, however, is that hydrogen, being the lightest and smallest of gases with a lower viscosity and density than natural gas, readily migrates through small spaces and is difficult to compresses efficiently. While efficient and cost effective compression technology is crucial to effective pipeline delivery of hydrogen, the compression methods used currently rely on oil lubricated positive displacement (PD) machines. PD compression technologymore » is very costly, has poor reliability and durability, especially for components subjected to wear (e.g., valves, rider bands and piston rings) and contaminates hydrogen with lubricating fluid. Even so called “oil-free” machines use oil lubricants that migrate into and contaminate the gas path. Due to the poor reliability of PD compressors, current hydrogen producers often install duplicate units in order to maintain on-line times of 98-99%. Such machine redundancy adds substantially to system capital costs. As such, DOE deemed that low capital cost, reliable, efficient and oil-free advanced compressor technologies are needed. MiTi’s solution is a completely oil-free, multi-stage, high-speed, centrifugal compressor designed for flow capacity of 500,000 kg/day with a discharge pressure of 1200 psig. The design employs oil-free compliant foil bearings and seals to allow for very high operating speeds, totally contamination free operation, long life and reliability. This design meets the DOE’s performance targets and achieves an extremely aggressive, specific power metric of 0.48 kW-hr/kg and provides significant improvements in reliability/durability, energy efficiency, sealing and freedom from contamination. The multi-stage compressor system concept has been validated through full scale performance testing of a single stage with helium similitude gas at full speed in accordance with ASME PTC-10. The experimental results indicated that aerodynamic performance, with respect to compressor discharge pressure, flow, power and efficiency exceeded theoretical prediction. Dynamic testing of a simulated multistage centrifugal compressor was also completed under a parallel program to validate the integrity and viability of the system concept. The results give strong confidence in the feasibility of the multi-stage design for use in hydrogen gas transportation and delivery from production locations to point of use.« less

Flood-inundation maps for the Flatrock River at Columbus, Indiana, 2012

USGS Publications Warehouse

Coon, William F.

2013-01-01

Digital flood-inundation maps for a 5-mile reach of the Flatrock River on the western side of Columbus, Indiana, from County Road 400N to the river mouth at the confluence with Driftwood River, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Department of Transportation. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ and the Federal Flood Inundation Mapper Web site at http://wim.usgs.gov/FIMI/FloodInundationMapper.html, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage on the Flatrock River at Columbus (station number 03363900). Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service, which also presents the USGS data, at http:/water.weather.gov/ahps/. Flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relation at the Flatrock River streamgage, high-water marks that were surveyed following the flood of June 7, 2008, and water-surface profiles from the current flood-insurance study for the City of Columbus. The hydraulic model was then used to compute 12 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum and ranging from 9 ft or near bankfull to 20 ft, which exceeds the stages that correspond to both the estimated 0.2-percent annual exceedance probability flood (500-year recurrence interval flood) and the maximum recorded peak flow. The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from Light Detection and Ranging (LiDAR) data having a 0.37 ft vertical accuracy and 3.9 ft horizontal resolution) to delineate the area flooded at each water level. The availability of these maps on the USGS Federal Flood Inundation Mapper Web site, along with Internet information regarding current stage from the USGS streamgage, will provide emergency management personnel and residents with information that is critical for flood response activities, such as evacuations and road closures, as well as for post-flood recovery efforts.

An expanded model: flood-inundation maps for the Leaf River at Hattiesburg, Mississippi, 2013

USGS Publications Warehouse

Storm, John B.

2014-01-01

Digital flood-inundation maps for a 6.8-mile reach of the Leaf River at Hattiesburg, Mississippi (Miss.), were created by the U.S. Geological Survey (USGS) in cooperation with the City of Hattiesburg, City of Petal, Forrest County, Mississippi Emergency Management Agency, Mississippi Department of Homeland Security, and the Emergency Management District. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Leaf River at Hattiesburg, Miss. (station no. 02473000). Current conditions for estimating near-real-time areas of inundation by use of USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. NWS-forecasted peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relations at the Leaf River at Hattiesburg, Miss. streamgage (02473000) and documented high-water marks from recent and historical floods. The hydraulic model was then used to determine 13 water-surface profiles for flood stages at 1.0-foot intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system (GIS) digital elevation model (DEM, derived from light detection and ranging (lidar) data having a 0.6-foot vertical and 9.84-foot horizontal resolution) in order to delineate the area flooded at each water level. Development of the estimated flood inundation maps as described in this report update previously published inundation estimates by including reaches of the Bouie and Leaf Rivers above their confluence. The availability of these maps along with Internet information regarding current stage from USGS streamgages and forecasted stream stages from the NWS provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post flood recovery efforts.

The formation of the solar system

NASA Astrophysics Data System (ADS)

Pfalzner, S.; Davies, M. B.; Gounelle, M.; Johansen, A.; Münker, C.; Lacerda, P.; Portegies Zwart, S.; Testi, L.; Trieloff, M.; Veras, D.

2015-06-01

The solar system started to form about 4.56 Gyr ago and despite the long intervening time span, there still exist several clues about its formation. The three major sources for this information are meteorites, the present solar system structure and the planet-forming systems around young stars. In this introduction we give an overview of the current understanding of the solar system formation from all these different research fields. This includes the question of the lifetime of the solar protoplanetary disc, the different stages of planet formation, their duration, and their relative importance. We consider whether meteorite evidence and observations of protoplanetary discs point in the same direction. This will tell us whether our solar system had a typical formation history or an exceptional one. There are also many indications that the solar system formed as part of a star cluster. Here we examine the types of cluster the Sun could have formed in, especially whether its stellar density was at any stage high enough to influence the properties of today’s solar system. The likelihood of identifying siblings of the Sun is discussed. Finally, the possible dynamical evolution of the solar system since its formation and its future are considered.

The mammalian respiratory system and critical windows of exposure for children's health.

PubMed Central

Pinkerton, K E; Joad, J P

2000-01-01

The respiratory system is a complex organ system composed of multiple cell types involved in a variety of functions. The development of the respiratory system occurs from embryogenesis to adult life, passing through several distinct stages of maturation and growth. We review embryonic, fetal, and postnatal phases of lung development. We also discuss branching morphogenesis and cellular differentiation of the respiratory system, as well as the postnatal development of xenobiotic metabolizing systems within the lungs. Exposure of the respiratory system to a wide range of chemicals and environmental toxicants during perinatal life has the potential to significantly affect the maturation, growth, and function of this organ system. Although the potential targets for exposure to toxic factors are currently not known, they are likely to affect critical molecular signals expressed during distinct stages of lung development. The effects of exposure to environmental tobacco smoke during critical windows of perinatal growth are provided as an example leading to altered cellular and physiological function of the lungs. An understanding of critical windows of exposure of the respiratory system on children's health requires consideration that lung development is a multistep process and cannot be based on studies in adults. Images Figure 1 Figure 4 PMID:10852845

An Improved X-Band Maser System for Deep Space Network Applications

NASA Astrophysics Data System (ADS)

Britcliffe, M.; Hanson, T.; Fernandez, J.

2000-01-01

An 8450-MHz (X-band) maser system utilizing a commercial Gifford--McMahon (GM) closed-cycle cryocooler (CCR) was designed, fabricated, and demonstrated. The CCR system was used to cool a maser operating at 8450 MHz. The prototype GM CCR system meets or exceeds all Deep Space Network requirements for maser performance. The two-stage GM CCR operates at 4.2 K; for comparison, the DSN's current three-stage cryocooler, which uses a Joule--Thompson cooling stage in addition to GM cooling, operates at 4.5 K. The new CCR withstands heat loads of 1.5 W at 4.2 K as compared to 1 W at 4.5 K for the existing DSN cryocooler used for cooling masers. The measured noise temperature, T_e, of the maser used for these tests is defined at the ambient connection to the antenna feed system. The T_e measured 5.0 K at a CCR temperature of 4.5 K, about 1.5 K higher than the noise temperature of a typical DSN Block II-A X-band traveling-wave maser (TWM). Reducing the temperature of the CCR significantly lowers the maser noise temperature and increases maser gain and bandwidth. The new GM CCR gives future maser systems significant operational advantages, including reduced maintenance time and logistics requirements. The results of a demonstration of this new system are presented. Advantages of using a GM-cooled maser and the effects of the reduced CCR temperature on maser performance are discussed.

Cavity ring down spectrometry for disease diagnostics using exhaled air

NASA Astrophysics Data System (ADS)

Revalde, G.; Grundšteins, K.; Alnis, J.; Skudra, A.

2017-12-01

In this paper we report the current stage of the development of a cavity ring-down spectrometer (CRDS) system using exhaled human breath analysis for the diagnostics of different diseases like diabetes and later lung cancer. The portable CRDS system is made in ultraviolet spectral region using Nd:Yag laser 266 nm pulsed light. Calibration of the CRDS system was performed using generated samples by KinTek automated permeation tube system and self-prepared mixtures with known concentration of benzene and acetone in air. First experiments showed that the limits of detection for benzene and acetone are several tens of ppb.

Flood-inundation maps for the Driftwood River and Sugar Creek near Edinburgh, Indiana

USGS Publications Warehouse

Fowler, Kathleen K.; Kim, Moon H.; Menke, Chad D.

2012-01-01

Digital flood-inundation maps for an 11.2 mile reach of the Driftwood River and a 5.2 mile reach of Sugar Creek, both near Edinburgh, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Camp Atterbury Joint Maneuver Training Center, Edinburgh, Indiana. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent of flooding corresponding to selected water levels (stages) at the USGS streamgage 03363000 Driftwood River near Edinburgh, Ind. Current conditions at the USGS streamgage in Indiana may be obtained on the Internet at http://waterdata.usgs.gov/in/nwis/current/?type=flow. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system at http://water.weather.gov/ahps/. The NWS forecasts flood hydrographs at many places that are often collocated at USGS streamgages. That forecasted peak-stage information, also available on the Internet, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. For this study, flood profiles were computed for the stream reaches by means of a one-dimensional step-backwater model. The model was calibrated using the most current stage-discharge relations at the USGS streamgage 03363000 Driftwood River near Edinburgh, Ind. The hydraulic model was then used to determine elevations throughout the study reaches for nine water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from bankfull to nearly the highest recorded water level at the USGS streamgage 03363000 Driftwood River near Edinburgh, Ind. The simulated water-surface profiles were then combined with a geospatial digital elevation model (derived from Light Detection and Ranging (LiDAR) data) in order to delineate the area flooded at each water level. The availability of these maps along with real-time information available online regarding current stage from USGS streamgages and forecasted stream stages from the NWS provide emergency management personnel and residents with information that is critical for flood response activities such as evacuations and road closures as well as for post flood recovery efforts.

Featuring of transient tunneling current by voltage pulse and application to an electrochemical biosensor

NASA Astrophysics Data System (ADS)

Yun, Jun Yeon; Lee, Won Cheol; Choi, Seong Wook; Park, Young June

2018-03-01

We suggest a voltage pulse method for detecting the transient tunneling current component (faradaic current component) in a metal/redox-active monolayer/electrolyte system. After applying the pulse to the metal electrode, the capacitive current prevails; therefore, it is difficult to extract the tunneling current, which carries information on the biochemical reactions occurring between the biomarkers in the electrolyte and the self-assembled monolayer (SAM) as the probe peptide system. Instead of waiting until the capacitive current diminishes, and thereby, the tunneling current also decreases, we try to extract the tunneling current in an early stage of the pulse. The method is based on the observation that the capacitive current becomes symmetrized in the positive and negative pulses after introducing the SAM on the metal electrode. When the energy level of the redox molecule is higher than the Fermi level of the metal under zero-bias condition, the tunneling current in the negative pulse can be extracted by subtracting the capacitive current obtained from the positive pulse, where the tunneling current is neglected. The experiment conducted for detecting trypsin as a biomarker shows that the method enhances the sensitivity and the specific-to-nonspecific ratio of the sensor device in the case of the nonspecific protein-abundant electrolyte solution, as evinced by cyclic voltammetry measurements in comparison.

Male breast cancer; analysis of 58 cases in Shiraz, South of Iran.

PubMed

Tahmasebi, Sedigheh; Akrami, Majid; Omidvari, Shapoor; Salehi, Alireza; Talei, Abdolrasoul

2010-01-01

male breast cancer (MBC) is very rare and accounts for less than one percent of all cancers in men. Because of the low incidence of MBC it has not attracted extensive studies. The current study is the first cohort of men with breast carcinoma reported in our country to date. We retrospectively reviewed the medical records of 58 MBC patients who had been treated at Shahid Faghihi Hospital in Shiraz, Iran, between 1990 and 2007. Data regarding general characteristics of patients including: age at time of diagnosis, family history of breast cancer, site, stage, size and location of tumor, histopathology of primary tumor, and treatment modalities (surgery, chemotherapy, radiation and hormone therapy) were obtained by reviewing medical records. among 58 MBC patients included in current study, 98.3% of patients were presented with a palpable mass, while 22.4% had breast skin deformity, and 12.1% patients had breast discharge. The median age at time of diagnosis was 60 years (range, 34-84 years). Infiltrative ductal carcinoma was found in 96.2% of patients, insitu ductal carcinoma in 3.8% of patients. The histopathological diagnosis of 5 breast tumors was missed. 4.3% of tumors were diagnosed in stage 0, 10.6% in stage one, 74.5% in stage two, and 10.6% in stage three. Regional lymph node involvement were diagnosed in 20.7% of patients, and 15.5% patients had distant metastasis at the time of diagnosis. this study, in spite of limitations, suggests that the incidence of MBC is increasing, and men are diagnosed with later-stage disease than women. Therefore, MBC screening should become a part of female breast cancer registry system.

Immigration and early life stages recruitment of the European flounder (Platichthys flesus) to an estuarine nursery: The influence of environmental factors

NASA Astrophysics Data System (ADS)

Amorim, Eva; Ramos, Sandra; Elliott, Michael; Bordalo, Adriano A.

2016-01-01

Connectivity between coastal spawning grounds and estuarine nurseries is a critical step in the life cycle of many fish species. Larval immigration and transport-associated physical-biological processes are determinants of recruitment success to nursery areas. The recruitment of the European flounder, Platichthys flesus, to estuarine nurseries located at the southern edge of the species distribution range, has been usually investigated during its juvenile stages, while estuarine recruitment during the earlier planktonic life stage remains largely unstudied. The present study investigated the patterns of flounder larval recruitment and the influence of environmental factors on the immigration of the early life stages to the Lima estuary (NW Portugal), integrating data on fish larvae and post-settlement individuals (< 50 mm length), collected over 7 years. Late-stage larvae arrived at the estuary between February and July and peak abundances were observed in April. Post-settlement individuals (< 50 mm) occurred later between April and October, whereas newly-settled ones (< 20 mm) were found only in May and June. Variables associated with the spawning, survival and growth of larvae in the ocean (sea surface temperature, chlorophyll a and inland hydrological variables) were the major drivers of flounder occurrence in the estuarine nursery. Although the adjacent coastal area is characterized by a current system with strong seasonality and mesoscale variability, we did not identify any influence of variables related with physical processes (currents and upwelling) on the occurrence of early life stages in the estuary. A wider knowledge on the influence of the coastal circulation variability and its associated effects upon ocean-estuarine connectivity is required to improve our understanding of the population dynamics of marine spawning fish that use estuarine nurseries.

Flood-inundation maps for the Suncook River in Epsom, Pembroke, Allenstown, and Chichester, New Hampshire

USGS Publications Warehouse

Flynn, Robert H.; Johnston, Craig M.; Hays, Laura

2012-01-01

Digital flood-inundation maps for a 16.5-mile reach of the Suncook River in Epsom, Pembroke, Allenstown, and Chichester, N.H., from the confluence with the Merrimack River to U.S. Geological Survey (USGS) Suncook River streamgage 01089500 at Depot Road in North Chichester, N.H., were created by the USGS in cooperation with the New Hampshire Department of Homeland Security and Emergency Management. The inundation maps presented in this report depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Suncook River at North Chichester, N.H. (station 01089500). The current conditions at the USGS streamgage may be obtained on the Internet (http://waterdata.usgs.gov/nh/nwis/uv/?site_no=01089500&PARAmeter_cd=00065,00060). The National Weather Service forecasts flood hydrographs at many places that are often collocated with USGS streamgages. Forecasted peak-stage information is available on the Internet at the National Weather Service (NWS) Advanced Hydrologic Prediction Service (AHPS) flood-warning system site (http://water.weather.gov/ahps/) and may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. These maps along with real-time stream stage data from the USGS Suncook River streamgage (station 01089500) and forecasted stream stage from the NWS will provide emergency management personnel and residents with information that is critical for flood-response activities, such as evacuations, road closures, disaster declarations, and post-flood recovery. The maps, along with current stream-stage data from the USGS Suncook River streamgage and forecasted stream-stage data from the NWS, can be accessed at the USGS Flood Inundation Mapping Science Web site http://water.usgs.gov/osw/flood_inundation/.

The effect of lactation number, stage, length, and milking frequency on milk yield in Korean Holstein dairy cows using automatic milking system

PubMed Central

Vijayakumar, Mayakrishnan; Park, Ji Hoo; Ki, Kwang Seok; Lim, Dong Hyun; Kim, Sang Bum; Park, Seong Min; Jeong, Ha Yeon; Park, Beom Young; Kim, Tae Il

2017-01-01

Objective The aim of the current study was to describe the relationship between milk yield and lactation number, stage, length and milking frequency in Korean Holstein dairy cows using an automatic milking system (AMS). Methods The original data set consisted of observations from April to October 2016 of 780 Holstein cows, with a total of 10,751 milkings. Each time a cow was milked by an AMS during the 24 h, the AMS management system recorded identification numbers of the AMS unit, the cow being milking, date and time of the milking, and milk yield (kg) as measured by the milk meters installed on each AMS unit, date and time of the lactation, lactation stage, milking frequency (NoM). Lactation stage is defined as the number of days milking per cows per lactation. Milk yield was calculated per udder quarter in the AMS and was added to 1 record per cow and trait for each milking. Milking frequency was measured the number of milkings per cow per 24 hour. Results From the study results, a significant relationship was found between the milk yield and lactation number (p<0.001), with the maximum milk yield occurring in the third lactation cows. We recorded the highest milk yield, in a greater lactation length period of early stage (55 to 90 days) at a 4× milking frequency/d, and the lowest milk yield was observed in the later stage (>201 days) of cows. Also, milking frequency had a significant influence on milk yield (p<0.001) in Korean Holstein cows using AMS. Conclusion Detailed knowledge of these factors such as lactation number, stage, length, and milking frequency associated with increasing milk yield using AMS will help guide future recommendations to producers for maximizing milk yield in Korean Dairy industries. PMID:28423887

Active magnetic bearings applied to industrial compressors

NASA Technical Reports Server (NTRS)

Kirk, R. G.; Hustak, J. F.; Schoeneck, K. A.

1993-01-01

The design and shop test results are given for a high-speed eight-stage centrifugal compressor supported by active magnetic bearings. A brief summary of the basic operation of active magnetic bearings and the required rotor dynamics analysis are presented with specific attention given to design considerations for optimum rotor stability. The concerns for retrofits of magnetic bearings in existing machinery are discussed with supporting analysis of a four-stage centrifugal compressor. The current status of industrial machinery in North America using this new support system is presented and recommendations are given on design and analysis requirements for successful machinery operation of either retrofit or new design turbomachinery.

Clinical outcome of head and neck cancer patients: a comparison between ENT patients referred via the 2 weeks wait pathway and alternative routes in the UK health system.

PubMed

Wong, B Y Winson; Fischer, S; Cruickshank, H E

2017-01-01

2 weeks wait (2ww) referral was intended to improve cancer outcomes in the UK. However, a previous study found that 2ww failed to detect early stage head and neck cancer. There is no current study to examine the survival outcome of head and neck cancer patients diagnosed on 2ww and non-2ww pathways. The aim of this study is to compare the outcome of cancer patients diagnosed on these pathways. We performed a retrospective review of head and neck cancer patients diagnosed between 2009 and 2013 in the ENT Department at Mid-Yorkshire NHS Hospitals Trust. Gender, age, disease staging, treatment modalities, route of referrals along with survival data were documented. Survival analysis was performed for 2ww and non-2ww cancer patients. There were 4123 patients referred on 2ww during the study period. 147 patients were diagnosed with cancers on 2ww and 89 patients were diagnosed on non-2ww. There were no statistical differences in clinical staging (p = 0.416) and overall survival (p = 0.376) between 2ww and non-2ww patients. This study failed to demonstrate a better overall survival in head and neck cancer patients diagnosed on 2ww pathway within the ENT cohort. Current referral system needs to be refined to improve the survival outcome in head and neck cancer patients.

Isotherms for Water Adsorption on Molecular Sieve 3A: Influence of Cation Composition

DOE PAGES

Lin, Ronghong; Ladshaw, Austin; Nan, Yue; ...

2015-06-16

This study is part of our continuing efforts to address engineering issues related to the removal of tritiated water from off-gases produced in used nuclear fuel reprocessing facilities. In the current study, adsorption equilibrium of water on molecular sieve 3A beads was investigated. Adsorption isotherms for water on the UOP molecular sieve 3A were measured by a continuous-flow adsorption system at 298, 313, 333, and 353 K. Experimental data collected were analyzed by the Generalized Statistical Thermodynamic Adsorption (GSTA) isotherm model. The K +/Na + molar ratio of this particular type of molecular sieve 3A was ~4:6. Our results showedmore » that the GSTA isotherm model worked very well to describe the equilibrium behavior of water adsorption on molecular sieve 3A. The optimum number of parameters for the current experimental data was determined to be a set of four equilibrium parameters. This result suggests that the adsorbent crystals contain four energetically distinct adsorption sites. In addition, it was found that water adsorption on molecular sieve 3A follows a three-stage adsorption process. This three-stage adsorption process confirmed different water adsorption sites in molecular sieve crystals. In addition, the second adsorption stage is significantly affected by the K +/Na + molar ratio. In this stage, the equilibrium adsorption capacity at a given water vapor pressure increases as the K +/Na + molar ratio increases.« less

A numerical modeling study of the East Australian Current encircling and overwashing a warm-core eddy

NASA Astrophysics Data System (ADS)

MacDonald, H. S.; Roughan, M.; Baird, M. E.; Wilkin, J.

2013-01-01