THz based electron bunch length monitoring at the quasi-cw SRF accelerator ELBE

NASA Astrophysics Data System (ADS)

Green, Bertram; Kovalev, Sergey; Fisher, Alan; Bauer, Christian; Kuntzsch, Michael; Lehnert, Ulf; Schurig, Rico; Goltz, Torsten; Michel, Peter; Stojanovic, Nikola; Gensch, Michael

2014-03-01

In the past few years the quasi-cw SRF electron accelerator ELBE has been upgraded so that it now allows to compress electron bunches to the sub-picosecond regime. The actual optimization and control of the electron bunch form represents one of the largest challenges of the coming years. In particular with respect to the midterm goal to utilize the ultra-short electron bunches for Laser-Thomson scattering experiments or high field THz experiments. Current developments of THz based electron bunch diagnostic are discussed and an outlook into future developments is given.

A 1 GeV CW FFAG High Intensity Proton Driver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnstone, C.; Sheehy, S. L.

2012-05-01

The drive for high beam power, high duty cycle, and reliable beams at reasonable cost has focused world attention on fixed-field accelerators, notably Fixed-Field Alternating Gradient accelerators (FFAGs). High-intensity GeV proton drivers are of particular interest, as these encounter duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotron. Recently, the concept of isochronous orbits has been explored and developed for non-scaling FFAGs using powerful new methodologies in FFAG accelerator design. These new breeds of FFAGs have been identified by international collaborations for serious study thanks to their potential applications including Accelerator Driven Subcriticalmore » Reactors (ADS) a nd Accelerator Transmutation of Waste. The extreme reliability requirements for ADS mandate CW operation capability and the FFAG s strong focusing, particularly in the vertical, will serve to mitigate the effect of space charge (as compared with the weak- focusing cyclotron). This paper reports on these new advances in FFAG accelerator technology and presents a stable, 0.25-1GeV isochronous FFAG for an accelerator driven subcritical reactor.« less

The Sao Paulo Microtron: Equipment and Planned Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martins, M. N.; Maidana, N. L.; Vanin, V. R.

2007-10-26

The Linear Accelerator Laboratory (LAL) of the Instituto de Fisica da Universidade de Sao Paulo (IFUSP) is building a two-stage racetrack microtron, which will generate continuous wave electron beams with energies up to 38 MeV. This paper describes the characteristics of the accelerator, and reports on the experimental equipment that will be available in order to pursue the photonuclear physics research program. Operation will begin with the first stage (5 MeV), and concentrate on NRF (Nuclear Resonance Fluorescence) measurements and radiation physics studies. Planned experiments for the second stage explore the cw character of the beam on coincidence experiments. Amore » photon tagger has been already tested with radioactive sources and is ready to be installed. Gamma and neutron detector arrays are being developed for the detailed study of photoneutron reactions. Plans include the study of NRF and pygmy resonances, near the neutron binding energy.« less

Modeling and simulation of continuous wave velocity radar based on third-order DPLL

NASA Astrophysics Data System (ADS)

Di, Yan; Zhu, Chen; Hong, Ma

2015-02-01

Second-order digital phase-locked-loop (DPLL) is widely used in traditional Continuous wave (CW) velocity radar with poor performance in high dynamic conditions. Using the third-order DPLL can improve the performance. Firstly, the echo signal model of CW radar is given. Secondly, theoretical derivations of the tracking performance in different velocity conditions are given. Finally, simulation model of CW radar is established based on Simulink tool. Tracking performance of the two kinds of DPLL in different acceleration and jerk conditions is studied by this model. The results show that third-order PLL has better performance in high dynamic conditions. This model provides a platform for further research of CW radar.

Very low scale Coleman-Weinberg inflation with nonminimal coupling

NASA Astrophysics Data System (ADS)

Kaneta, Kunio; Seto, Osamu; Takahashi, Ryo

2018-03-01

We study viable small-field Coleman-Weinberg (CW) inflation models with the help of nonminimal coupling to gravity. The simplest small-field CW inflation model (with a low-scale potential minimum) is incompatible with the cosmological constraint on the scalar spectral index. However, there are possibilities to make the model realistic. First, we revisit the CW inflation model supplemented with a linear potential term. We next consider the CW inflation model with a logarithmic nonminimal coupling and illustrate that the model can open a new viable parameter space that includes the model with a linear potential term. We also show parameter spaces where the Hubble scale during the inflation can be as small as 10-4 GeV , 1 GeV, 1 04 GeV , and 1 08 GeV for the number of e -folds of 40, 45, 50, and 55, respectively, with other cosmological constraints being satisfied.

Intermediate quality control tests in the development of a superconducting RF cryomodule for CW operation

NASA Astrophysics Data System (ADS)

Pattalwar, Shrikant; Jones, Thomas; Strachan, John; Bate, Robert; Davies, Phil; McIntosh, Peter

2012-06-01

Through an international cryomodule collaboration, ASTeC at Daresbury Laboratory has taken the primary responsibility in leading the development of an optimised Superconducting RF (SRF) cryomodule, operating in CW mode for energy recovery facilities and other high duty cycle accelerators. For high beam current operation, Higher Order Mode (HOM) absorbers are critical components of the SRF Cryomodule, ensuring excessive heating of the accelerating structures and beam instabilities are effectively managed. This paper describes some of the cold tests conducted on the HOM absorbers and other critical components during the construction phase, to ensure that the quality and reliable cryomodule performance is maintained.

Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alarcon, Ricardo; Balascuta, S.; Benson, Stephen V.

2013-11-01

We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-off, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that needmore » to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, multipactoring inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation when the machine is tuned for 130 MeV operation.« less

A Two-stage Injection-locked Magnetron for Accelerators with Superconducting Cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazakevich, Grigory; Flanagan, Gene; Johnson, Rolland

2012-05-01

A concept for a two-stage injection-locked CW magnetron intended to drive Superconducting Cavities (SC) for intensity-frontier accelerators has been proposed. The concept considers two magnetrons in which the output power differs by 15-20 dB and the lower power magnetron being frequency-locked from an external source locks the higher power magnetron. The injection-locked two-stage CW magnetron can be used as an RF power source for Fermilab's Project-X to feed separately each of the 1.3 GHz SC of the 8 GeV pulsed linac. We expect output/locking power ratio of about 30-40 dB assuming operation in a pulsed mode with pulse duration ofmore » ~ 8 ms and repetition rate of 10 Hz. The experimental setup of a two-stage magnetron utilising CW, S-band, 1 kW tubes operating at pulse duration of 1-10 ms, and the obtained results are presented and discussed in this paper.« less

Task-control of arousal and the effects of repeated unidirectional angular acceleration on human vestibular responses.

DOT National Transportation Integrated Search

1963-11-01

Subjects were exposed to a 10-day habituation series of 200 CW accelerations in total darkness while performing attention-demanding tasks. Decelerations were sub-threshold. Preliminary and post-tests indicated that slow-phase nystagmus and duration o...

Slow positron beam production by a 14 MeV C.W. electron accelerator

NASA Astrophysics Data System (ADS)

Begemann, M.; Gräff, G.; Herminghaus, H.; Kalinowsky, H.; Ley, R.

1982-10-01

A 14 MeV c.w. electron accelerator is used for pair production in a tungsten target of 0.7 radiation lengths thickness. A small fraction of the positrons is thermalized and diffuses out of the surface ofsurface of a well annealed tungsten foil coated with MgO which is positioned immediately behind the target. The slow positrons are extracted from the target region and magnetically guided over a distance of 10 m onto a channelplate multiplier at the end of an S-shaped solenoid. The positrons are identified by their annihilation radiation using two NaI-detectors. The intensity of the slow positrons is proportional to the accelerator electron beam current. The maximum intensity of 2.2 × 10 5 slow positrons per second reaching thedetector at an accelerator current of 15 μA was limited by the power deposited in the uncooled target. The energy of the positrons is concentrated in a small region at about 1 eV and clearly demonstrates the emission of thermal positrons.

Design of an 81.25 MHz continuous-wave radio-frequency quadrupole accelerator for Low Energy Accelerator Facility

NASA Astrophysics Data System (ADS)

Ma, Wei; Lu, Liang; Xu, Xianbo; Sun, Liepeng; Zhang, Zhouli; Dou, Weiping; Li, Chenxing; Shi, Longbo; He, Yuan; Zhao, Hongwei

2017-03-01

An 81.25 MHz continuous wave (CW) radio frequency quadrupole (RFQ) accelerator has been designed for the Low Energy Accelerator Facility (LEAF) at the Institute of Modern Physics (IMP) of the Chinese Academy of Science (CAS). In the CW operating mode, the proposed RFQ design adopted the conventional four-vane structure. The main design goals are providing high shunt impendence with low power losses. In the electromagnetic (EM) design, the π-mode stabilizing loops (PISLs) were optimized to produce a good mode separation. The tuners were also designed and optimized to tune the frequency and field flatness of the operating mode. The vane undercuts were optimized to provide a flat field along the RFQ cavity. Additionally, a full length model with modulations was set up for the final EM simulations. Following the EM design, thermal analysis of the structure was carried out. In this paper, detailed EM design and thermal simulations of the LEAF-RFQ will be presented and discussed. Structure error analysis was also studied.

The response of thermally and optically stimulated luminescence from Al2O3:C to high-energy heavy charged particles

NASA Technical Reports Server (NTRS)

Gaza, R.; Yukihara, E. G.; McKeever, S. W. S.

2004-01-01

The thermoluminescence (TL) and optically stimulated luminescence (OSL) response of Al2O3 dosimeters to high-energy heavy charged particles (HCP) has been studied using the heavy ion medical accelerator at Chiba, Japan. The samples were Al2O3 single-crystal chips, of the type usually known as TLD-500, and Luxel(TM) dosimeters (Al2O3:C powder in plastic) from Landauer Inc. The samples were exposed to 4He (150 MeV/u), 12C (400 MeV/u), 28Si (490 MeV/us) and 56Fe (500 MeV/u) ions, with linear energy transfer values covering the range from 2.26 to 189 keV/micrometers in water and doses from 1 to 100 mGy (to water). A 90Sr/90Y beta source, calibrated against a 60Co secondary standard, was used for calibration purposes. For OSL, we used both continuous-wave OSL measurements (CW-OSL, using green light stimulation at 525 nm) and pulsed OSL measurements (POSL, using 532 nm stimulation from a Nd:YAG Q-switched laser). The efficiencies (eta HCP, gamma) of the different HCPs at producing OSL or TL were observed to depend not only upon the linear energy transfer (LET) of the HCP, but also upon the sample type (single crystal chip or Luxel(TM)) and the luminescence method used to define the signal--i.e. TL, CW-OSL initial intensity, CW-OSL total area, or POSL. Observed changes in shape of the decay curve lead to potential methods for extracting LET information of unknown radiation fields. A discussion of the results is given, including the potential use of OSL from Al2O3 in the areas of space radiation dosimetry and radiation oncology. c2004 Elsevier Ltd. All rights reserved.

The response of thermally and optically stimulated luminescence from Al2O3:C to high-energy heavy charged particles.

PubMed

Gaza, R; Yukihara, E G; McKeever, S W S

2004-01-01

The thermoluminescence (TL) and optically stimulated luminescence (OSL) response of Al2O3 dosimeters to high-energy heavy charged particles (HCP) has been studied using the heavy ion medical accelerator at Chiba, Japan. The samples were Al2O3 single-crystal chips, of the type usually known as TLD-500, and Luxel(TM) dosimeters (Al2O3:C powder in plastic) from Landauer Inc. The samples were exposed to 4He (150 MeV/u), 12C (400 MeV/u), 28Si (490 MeV/us) and 56Fe (500 MeV/u) ions, with linear energy transfer values covering the range from 2.26 to 189 keV/micrometers in water and doses from 1 to 100 mGy (to water). A 90Sr/90Y beta source, calibrated against a 60Co secondary standard, was used for calibration purposes. For OSL, we used both continuous-wave OSL measurements (CW-OSL, using green light stimulation at 525 nm) and pulsed OSL measurements (POSL, using 532 nm stimulation from a Nd:YAG Q-switched laser). The efficiencies (eta HCP, gamma) of the different HCPs at producing OSL or TL were observed to depend not only upon the linear energy transfer (LET) of the HCP, but also upon the sample type (single crystal chip or Luxel(TM)) and the luminescence method used to define the signal--i.e. TL, CW-OSL initial intensity, CW-OSL total area, or POSL. Observed changes in shape of the decay curve lead to potential methods for extracting LET information of unknown radiation fields. A discussion of the results is given, including the potential use of OSL from Al2O3 in the areas of space radiation dosimetry and radiation oncology. c2004 Elsevier Ltd. All rights reserved.

Bulk metal concentrations versus total suspended solids in rivers: Time-invariant & catchment-specific relationships.

PubMed

Nasrabadi, Touraj; Ruegner, Hermann; Schwientek, Marc; Bennett, Jeremy; Fazel Valipour, Shahin; Grathwohl, Peter

2018-01-01

Suspended particles in rivers can act as carriers of potentially bioavailable metal species and are thus an emerging area of interest in river system monitoring. The delineation of bulk metals concentrations in river water into dissolved and particulate components is also important for risk assessment. Linear relationships between bulk metal concentrations in water (CW,tot) and total suspended solids (TSS) in water can be used to easily evaluate dissolved (CW, intercept) and particle-bound metal fluxes (CSUS, slope) in streams (CW,tot = CW + CSUS TSS). In this study, we apply this principle to catchments in Iran (Haraz) and Germany (Ammer, Goldersbach, and Steinlach) that show differences in geology, geochemistry, land use and hydrological characteristics. For each catchment, particle-bound and dissolved concentrations for a suite of metals in water were calculated based on linear regressions of total suspended solids and total metal concentrations. Results were replicable across sampling campaigns in different years and seasons (between 2013 and 2016) and could be reproduced in a laboratory sedimentation experiment. CSUS values generally showed little variability in different catchments and agree well with soil background values for some metals (e.g. lead and nickel) while other metals (e.g. copper) indicate anthropogenic influences. CW was elevated in the Haraz (Iran) catchment, indicating higher bioavailability and potential human and ecological health concerns (where higher values of CSUS/CW are considered as a risk indicator).

Bulk metal concentrations versus total suspended solids in rivers: Time-invariant & catchment-specific relationships

PubMed Central

Ruegner, Hermann; Schwientek, Marc; Bennett, Jeremy; Fazel Valipour, Shahin; Grathwohl, Peter

2018-01-01

Suspended particles in rivers can act as carriers of potentially bioavailable metal species and are thus an emerging area of interest in river system monitoring. The delineation of bulk metals concentrations in river water into dissolved and particulate components is also important for risk assessment. Linear relationships between bulk metal concentrations in water (CW,tot) and total suspended solids (TSS) in water can be used to easily evaluate dissolved (CW, intercept) and particle-bound metal fluxes (CSUS, slope) in streams (CW,tot = CW + CSUS TSS). In this study, we apply this principle to catchments in Iran (Haraz) and Germany (Ammer, Goldersbach, and Steinlach) that show differences in geology, geochemistry, land use and hydrological characteristics. For each catchment, particle-bound and dissolved concentrations for a suite of metals in water were calculated based on linear regressions of total suspended solids and total metal concentrations. Results were replicable across sampling campaigns in different years and seasons (between 2013 and 2016) and could be reproduced in a laboratory sedimentation experiment. CSUS values generally showed little variability in different catchments and agree well with soil background values for some metals (e.g. lead and nickel) while other metals (e.g. copper) indicate anthropogenic influences. CW was elevated in the Haraz (Iran) catchment, indicating higher bioavailability and potential human and ecological health concerns (where higher values of CSUS/CW are considered as a risk indicator). PMID:29342204

High power ring methods and accelerator driven subcritical reactor application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tahar, Malek Haj

2016-08-07

High power proton accelerators allow providing, by spallation reaction, the neutron fluxes necessary in the synthesis of fissile material, starting from Uranium 238 or Thorium 232. This is the basis of the concept of sub-critical operation of a reactor, for energy production or nuclear waste transmutation, with the objective of achieving cleaner, safer and more efficient process than today’s technologies allow. Designing, building and operating a proton accelerator in the 500-1000 MeV energy range, CW regime, MW power class still remains a challenge nowadays. There is a limited number of installations at present achieving beam characteristics in that class, e.g.,more » PSI in Villigen, 590 MeV CW beam from a cyclotron, SNS in Oakland, 1 GeV pulsed beam from a linear accelerator, in addition to projects as the ESS in Europe, a 5 MW beam from a linear accelerator. Furthermore, coupling an accelerator to a sub-critical nuclear reactor is a challenging proposition: some of the key issues/requirements are the design of a spallation target to withstand high power densities as well as ensure the safety of the installation. These two domains are the grounds of the PhD work: the focus is on the high power ring methods in the frame of the KURRI FFAG collaboration in Japan: upgrade of the installation towards high intensity is crucial to demonstrate the high beam power capability of FFAG. Thus, modeling of the beam dynamics and benchmarking of different codes was undertaken to validate the simulation results. Experimental results revealed some major losses that need to be understood and eventually overcome. By developing analytical models that account for the field defects, one identified major sources of imperfection in the design of scaling FFAG that explain the important tune variations resulting in the crossing of several betatron resonances. A new formula is derived to compute the tunes and properties established that characterize the effect of the field imperfections on the transverse beam dynamics. The results obtained allow to develop a correction scheme to minimize the tune variations of the FFAG. This is the cornerstone of a new fixed tune non-scaling FFAG that represents a potential candidate for high power applications. As part of the developments towards high power at the KURRI FFAG, beam dynamics studies have to account for space charge effects. In that framework, models have been installed in the tracking code ZGOUBI to account for the self-interaction of the particles in the accelerator. Application to the FFAG studies is shown. Finally, one focused on the ADSR concept as a candidate to solve the problem of nuclear waste. In order to establish the accelerator requirements, one compared the performance of ADSR with other conventional critical reactors by means of the levelized cost of energy. A general comparison between the different accelerator technologies that can satisfy these requirements is finally presented. In summary, the main drawback of the ADSR technology is the high Levelized Cost Of Energy compared to other advanced reactor concepts that do not employ an accelerator. Nowadays, this is a show-stopper for any industrial application aiming at producing energy (without dealing with the waste problem). Besides, the reactor is not intrinsically safer than critical reactor concepts, given the complexity of managing the target interface between the accelerator and the reactor core.« less

Design of a high-bunch-charge 112-MHz superconducting RF photoemission electron source

NASA Astrophysics Data System (ADS)

Xin, T.; Brutus, J. C.; Belomestnykh, Sergey A.; Ben-Zvi, I.; Boulware, C. H.; Grimm, T. L.; Hayes, T.; Litvinenko, Vladimir N.; Mernick, K.; Narayan, G.; Orfin, P.; Pinayev, I.; Rao, T.; Severino, F.; Skaritka, J.; Smith, K.; Than, R.; Tuozzolo, J.; Wang, E.; Xiao, B.; Xie, H.; Zaltsman, A.

2016-09-01

High-bunch-charge photoemission electron-sources operating in a continuous wave (CW) mode are required for many advanced applications of particle accelerators, such as electron coolers for hadron beams, electron-ion colliders, and free-electron lasers. Superconducting RF (SRF) has several advantages over other electron-gun technologies in CW mode as it offers higher acceleration rate and potentially can generate higher bunch charges and average beam currents. A 112 MHz SRF electron photoinjector (gun) was developed at Brookhaven National Laboratory to produce high-brightness and high-bunch-charge bunches for the coherent electron cooling proof-of-principle experiment. The gun utilizes a quarter-wave resonator geometry for assuring beam dynamics and uses high quantum efficiency multi-alkali photocathodes for generating electrons.

Installation, high-power conditioning and beam commissioning of the upgraded SARAF 4-rods RFQ

NASA Astrophysics Data System (ADS)

Weissman, L.; Perry, A.; Bechtold, A.; Berkovits, D.; Kaizer, B.; Luner, Y.; Niewieczerzal, P.; Rodnizki, J.; Silverman, I.; Shor, A.; Nusbaum, D.

2018-05-01

The original SARAF 3.8 m long 4-rod Radio Frequency Quadrupole (RFQ) has been successful in acceleration of 4 mA Continuous Wave (CW) proton beam and pulsed deuteron beam to 1.5 MeV/u. However, conditions for running CW deuteron beam have not been achieved in the original design. A new 4-rod structure has been designed and implemented, with the goal of reducing the RF power required for CW deuteron operation while slightly compromising the RFQ exit energy to 1.27 MeV/u. The new 4-rod structure was manufactured, and installed in place of the old rod electrodes. Superior field homogeneity was achieved. The RFQ was successfully conditioned to the RF power 200 kW required for CW deuteron operation, with sufficient power margin. The commissioning with proton and deuteron beams showed that most of beam parameters are close to the designed specifications. The first operation with CW RF power of 5 mA deuteron beam was demonstrated. In addition, a 1.1 mA CW deuteron beam was transported through the superconducting module. The future scope of RFQ improvements is discussed.

Lattice Design for a High-Power Infrared FEL

NASA Astrophysics Data System (ADS)

Douglas, D. R.

1997-05-01

A 1 kW infrared FEL, funded by the U.S. Navy, is under construction at Jefferson Lab. This device will be driven by a compact, 42 MeV, 5 mA, energy-recovering, CW SRF-based linear accelerator to produce light in the 3-6.6 μm range. The machine concept comprises a 10 MeV injector, a linac based on a single high-gradient Jefferson Lab accelerator cryomodule, a wiggler and optical cavity, and an energy-recovery recirculation arc. Energy recovery limits cost and technical risk by reducing the RF power requirements in the driver accelerator. Following deceleration to 10 MeV, the beam is dumped. Stringent phase space requirements at the wiggler, low beam energy, and high beam current subject the accelerator lattice to numerous constraints. Principal considerations include: transport and delivery to the FEL of a high-quality, high-current beam; the impact of coherent synchrotron radiation (CSR) during beam recirculation transport; beam optics aberration control, to provide low-loss energy-recovery transport of a 5% relative momentum spread, high-current beam; attention to possible beam breakup (BBU) instabilities in the recirculating accelerator; and longitudinal phase space management during beam transport, to optimize RF drive system control during energy recovery and FEL operation. The presentation will address the design process and design solution for an accelerator transport lattice that meets the requirements imposed by these physical phenomena and operational necessities.

R&D for a Soft X-Ray Free Electron Laser Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corlett, John; Attwood, David; Byrd, John

2009-06-08

Several recent reports have identified the scientific requirements for a future soft x-ray light source, and a high-repetition-rate free-electron laser (FEL) facility that is responsive to these requirements is now on the horizon. R&D in some critical areas is needed, however, to demonstrate technical performance, thus reducing technical risks and construction costs. Such a facility most likely will be based on a CW superconducting linear accelerator with beam supplied by a high-brightness, high-repetition-rate photocathode electron gun operating in CW mode, and on an array of FELs to which the accelerated beam is distributed, each operating at high repetition rate andmore » with even pulse spacing. Dependent on experimental requirements, the individual FELs can be configured for either self-amplified spontaneous emission (SASE), seeded, or oscillator mode of operation, including the use of high-gain harmonic generation (HGHG), echo-enhanced harmonic generation (EEHG), harmonic cascade, or other configurations. In this White Paper we identify the overall accelerator R&D needs, and highlight the most important pre-construction R&D tasks required to value-engineer the design configuration and deliverables for such a facility. In Section 1.4 we identify the comprehensive R&D ultimately needed. We identify below the highest-priority requirements for understanding machine performance and reduce risk and costs at this pre-conceptual design stage. Details of implementing the required tasks will be the subject of future evaluation. Our highest-priority R&D program is the injector, which must be capable of delivering a beam with bunches up to a nanocoulomb at MHz repetition rate and with normalized emittance {le} 1 mm {center_dot} mrad. This will require integrated accelerating structure, cathode, and laser systems development. Cathode materials will impact the choice of laser technology in wavelength and energy per pulse, as well as vacuum requirements in the accelerating structure. Demonstration experiments in advanced seeding techniques, such as EEHG, and other optical manipulations to enhance the FEL process are required to reduce technical risk in producing temporally coherent and ultrashort x-ray output using optical seed lasers. Success of EEHG in particular would result in reduced development and cost of laser systems and accelerator hardware for seeded FELs. With a 1.5-2.5 GeV linac, FELs could operate in the VUV-soft x-ray range, where the actual beam energy will be determined by undulator technology; for example, to use the lower energy would require the use of advanced designs for which undulator R&D is needed. Significant reductions in both unit costs and accelerator costs resulting from the lower electron beam energy required to achieve lasing at a particular wavelength could be obtained with undulator development. Characterization of the wakefields of the vacuum chambers in narrow-gap undulators will be needed to minimize risk in ability to deliver close to transform limited pulses. CW superconducting RF technology for an FEL facility with short bunches at MHz rate and up to mA average current will require selection of design choices in cavity frequency and geometry, higher order mode suppression and power dissipation, RF power supply and distribution, accelerating gradient, and cryogenics systems. R&D is needed to define a cost and performance optimum. Developments in laser technology are proceeding at rapid pace, and progress in high-power lasers, harmonic generation, and tunable sources will need to be tracked.« less

Reliability of constricted double-heterojunction AlGaAs diode lasers

NASA Technical Reports Server (NTRS)

Botez, D.; Connolly, J. C.; Ettenberg, M.; Gilbert, D. B.; Hughes, J. J.

1983-01-01

Constricted double-heterojunction diode lasers have been life tested at 70 C heatsink temperature and 3-4 mW/facet in CW operation. A median life of 7800 h is obtained at 70 C, which extrapolates to 400,000 h median life at room temperature. The extrapolated mean time to failure at room temperature is in excess of 1,000,000 h. Single-longitudinal-mode CW operation is maintained after 10,000 h of accelerated aging at 70 C.

Intracavity-pumped Raman laser action in a mid IR, continuous-wave (cw) MgO:PPLN optical parametric oscillator

NASA Astrophysics Data System (ADS)

Okishev, Andrey V.; Zuegel, Jonathan D.

2006-12-01

Intracavity-pumped Raman laser action in a fiber-laser pumped, single-resonant, continuous-wave (cw) MgO:PPLN optical parametric oscillator with a high-Q linear resonator has been observed for the first time to our knowledge. Experimental results of this phenomenon investigation will be discussed.

Measurements of Acceleration Due to Gravity.

ERIC Educational Resources Information Center

Crummett, Bill

1990-01-01

The principle means by which g has been measured are summarized. Discussed are "Kater's Reversible Pendulum," falling rules, and interferometry methods. Types of corrections and various sources of uncertainty are considered. (CW)

Power degradation and reliability study of high-power laser bars at quasi-CW operation

NASA Astrophysics Data System (ADS)

Zhang, Haoyu; Fan, Yong; Liu, Hui; Wang, Jingwei; Zah, Chungen; Liu, Xingsheng

2017-02-01

The solid state laser relies on the laser diode (LD) pumping array. Typically for high peak power quasi-CW (QCW) operation, both energy output per pulse and long term reliability are critical. With the improved bonding technique, specially Indium-free bonded diode laser bars, most of the device failures were caused by failure within laser diode itself (wearout failure), which are induced from dark line defect (DLD), bulk failure, point defect generation, facet mirror damage and etc. Measuring the reliability of LD under QCW condition will take a rather long time. Alternatively, an accelerating model could be a quicker way to estimate the LD life time under QCW operation. In this report, diode laser bars were mounted on micro channel cooler (MCC) and operated under QCW condition with different current densities and junction temperature (Tj ). The junction temperature is varied by modulating pulse width and repetition frequency. The major concern here is the power degradation due to the facet failure. Reliability models of QCW and its corresponding failures are studied. In conclusion, QCW accelerated life-time model is discussed, with a few variable parameters. The model is compared with CW model to find their relationship.

Multi-Maneuver Clohessy-Wiltshire Targeting

NASA Technical Reports Server (NTRS)

Dannemiller, David P.

2011-01-01

Orbital rendezvous involves execution of a sequence of maneuvers by a chaser vehicle to bring the chaser to a desired state relative to a target vehicle while meeting intermediate and final relative constraints. Intermediate and final relative constraints are necessary to meet a multitude of requirements such as to control approach direction, ensure relative position is adequate for operation of space-to-space communication systems and relative sensors, provide fail-safe trajectory features, and provide contingency hold points. The effect of maneuvers on constraints is often coupled, so the maneuvers must be solved for as a set. For example, maneuvers that affect orbital energy change both the chaser's height and downrange position relative to the target vehicle. Rendezvous designers use experience and rules-of-thumb to design a sequence of maneuvers and constraints. A non-iterative method is presented for targeting a rendezvous scenario that includes a sequence of maneuvers and relative constraints. This method is referred to as Multi-Maneuver Clohessy-Wiltshire Targeting (MM_CW_TGT). When a single maneuver is targeted to a single relative position, the classic CW targeting solution is obtained. The MM_CW_TGT method involves manipulation of the CW state transition matrix to form a linear system. As a starting point for forming the algorithm, the effects of a series of impulsive maneuvers on the state are derived. Simple and moderately complex examples are used to demonstrate the pattern of the resulting linear system. The general form of the pattern results in an algorithm for formation of the linear system. The resulting linear system relates the effect of maneuver components and initial conditions on relative constraints specified by the rendezvous designer. Solution of the linear system includes the straight-forward inverse of a square matrix. Inversion of the square matrix is assured if the designer poses a controllable scenario - a scenario where the the constraints can be met by the sequence of maneuvers. Matrices in the linear system are dependent on selection of maneuvers and constraints by the designer, but the matrices are independent of the chaser's initial conditions. For scenarios where the sequence of maneuvers and constraints are fixed, the linear system can be formed and the square matrix inverted prior to real-time operations. Example solutions are presented for several rendezvous scenarios to illustrate the utility of the method. The MM_CW_TGT method has been used during the preliminary design of rendezvous scenarios and is expected to be useful for iterative methods in the generation of an initial guess and corrections.

Design of a high-bunch-charge 112-MHz superconducting RF photoemission electron source

DOE PAGES

Xin, T.; Brutus, J. C.; Belomestnykh, Sergey A.; ...

2016-09-01

High-bunch-charge photoemission electron-sources operating in a continuous wave (CW) mode are required for many advanced applications of particle accelerators, such as electron coolers for hadron beams, electron-ion colliders, and free-electron lasers (FELs). Superconducting RF (SRF) has several advantages over other electron-gun technologies in CW mode as it offers higher acceleration rate and potentially can generate higher bunch charges and average beam currents. A 112 MHz SRF electron photoinjector (gun) was developed at Brookhaven National Laboratory (BNL) to produce high-brightness and high-bunch-charge bunches for the Coherent electron Cooling Proof-of-Principle (CeC PoP) experiment. Lastly, the gun utilizes a quarter-wave resonator (QWR) geometrymore » for assuring beam dynamics, and uses high quantum efficiency (QE) multi-alkali photocathodes for generating electrons.« less

Advances in Nonlinear Non-Scaling FFAGs

NASA Astrophysics Data System (ADS)

Johnstone, C.; Berz, M.; Makino, K.; Koscielniak, S.; Snopok, P.

Accelerators are playing increasingly important roles in basic science, technology, and medicine. Ultra high-intensity and high-energy (GeV) proton drivers are a critical technology for accelerator-driven sub-critical reactors (ADS) and many HEP programs (Muon Collider) but remain particularly challenging, encountering duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons; a 10-20 MW proton driver is not presently considered technically achievable with conventional re-circulating accelerators. One, as-yet, unexplored re-circulating accelerator, the Fixed-field Alternating Gradient or FFAG, is an attractive alternative to the other approaches to a high-power beam source. Its strong focusing optics can mitigate space charge effects and achieve higher bunch charges than are possible in a cyclotron, and a recent innovation in design has coupled stable tunes with isochronous orbits, making the FFAG capable of fixed-frequency, CW acceleration, as in the classical cyclotron but beyond their energy reach, well into the relativistic regime. This new concept has been advanced in non-scaling nonlinear FFAGs using powerful new methodologies developed for FFAG accelerator design and simulation. The machine described here has the high average current advantage and duty cycle of the cyclotron (without using broadband RF frequencies) in combination with the strong focusing, smaller losses, and energy variability that are more typical of the synchrotron. The current industrial and medical standard is a cyclotron, but a competing CW FFAG could promote a shift in this baseline. This paper reports on these new advances in FFAG accelerator technology and presents advanced modeling tools for fixed-field accelerators unique to the code COSY INFINITY.1

Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology.

PubMed

Sunaga, Hiroshi; Malhotra, Jaideep K; Yoon, Edward; Savarese, John J; Heerdt, Paul M

2010-04-01

CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. Six dogs were each studied four times during isoflurane-nitrous oxide anesthesia and recording of muscle twitch, arterial pressure, and heart rate. CW002 (0.08 mg/kg or 9 x ED95) was injected, and the time to spontaneous muscle recovery was determined. CW002 was then administered again followed 1 min later by 10, 20, 50, or 100 mg/kg L-cysteine (1 dose/experiment). After twitch recovery, CW002 was given a third time to determine whether residual L-cysteine influenced duration. Preliminary toxicology was performed in an additional group of dogs that received CW002 followed by vehicle (n = 8) or 200 mg/kg L-cysteine (n = 8). Animals were awakened and observed for 2 or 14 days before sacrificing and anatomic, biochemical, and histopathologic analyses. L-cysteine at all doses accelerated recovery from CW002, with both 50 and 100 mg/kg decreasing median duration from more than 70 min to less than 5 min. After reversal, duration of a subsequent CW002 dose was also decreased in a dose-dependent manner. Over the studied dose range, L-cysteine had less than 10% effect on blood pressure and heart rate. Animals receiving a single 200-mg/kg dose of L-cysteine showed no clinical, anatomic, biochemical, or histologic evidence of organ toxicity. The optimal L-cysteine dose for rapidly reversing the neuromuscular blockade produced by a large dose of CW002 in dogs is approximately 50 mg/kg, which has no concomitant hemodynamic effect. A dose of 200 mg/kg had no evident organ toxicity.

New low-dose 1-MeV cargo inspection system with backscatter imaging

NASA Astrophysics Data System (ADS)

Sapp, William W., Jr.; Rothschild, Peter J.; Schueller, Richard L.; Mishin, Andrey

2000-12-01

A new intermediate energy x-ray source is described which uses a cw electron linear accelerator created specifically for this application. This source has been installed in the hub of a hollow-spoked rotation wheel to form a scanning beam of x-rays. As cargo is transported through the inspection tunnel at speeds up to 6 inches per second it is raster-scanned by this beam to form digital images of the backscattered as well as the transmitted x-rays. The system will be described in detail, and sample images of a heavily loaded 8 foot wide ISO container will be presented. Environmental radiation due to the x-rays scattered from the cargo itself will be discussed in the context of the tradeoffs between penetration, spatial resolution, x-ray energy, and x-ray flux.

High-power linearly polarized diode-side-pumped a-cut Nd:GdVO4 rod laser

NASA Astrophysics Data System (ADS)

Li, Xiaowen; Qian, Jianqiang; Zhang, Baitao

2017-03-01

An efficiently high-power diode-side-pumped Nd:GdVO4 rod laser system was successfully demonstrated, operating in continuous wave (CW) and acousto-optically (AO) Q-switched regime. With a 65 mm-long a-cut Nd:GdVO4 crystal, a maximum linearly polarized CW output power of 60 W at 1063.2 nm was obtained under an absorbed pump power of 180 W, corresponding to a slope efficiency of 50.6%. The output laser beam was linearly polarized with a degree of polarization of 98%. In AO Q-switched operation, the highest output power, minimum pulse width, and highest peak power were achieved to be 42 W, 36 ns, and 58 kW at the pulse repetition frequency of 20 kHz.

Electron Accelerators for Research at the Frontiers of Nuclear Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartline, Beverly; Grunder, Hermann

1986-10-01

Electron accelerators for the frontiers of nuclear physics must provide high duty factor (gte 80) for coincidence measurements; few-hundred-MeV through few-GeV energy for work in the nucleonic, hadronic, and confinement regimes; energy resolution of ~ 10 -4; and high current (gte 100 zA). To fulfill these requirements new machines and upgrades of existing ones are being planned or constructed. Representative microtron-based facilities are the upgrade of MAMI at the University of Mainz (West Germany), the proposed two-stage cascade microtron at the University of Illinois (U.S.A.), and the three-stage Troitsk ``polytron'' (USSR). Representative projects to add pulse stretcher rings to existingmore » linacs are the upgrades at MIT-Bates (U.S.A.) and at NIKHEF-K (Netherlands). Recent advances in superconducting rf technology, especially in cavity design and fabrication, have made large superconducting cw linacs become feasible. Recirculating superconducting cw linacs are under construc« less

SRS modeling in high power CW fiber lasers for component optimization

NASA Astrophysics Data System (ADS)

Brochu, G.; Villeneuve, A.; Faucher, M.; Morin, M.; Trépanier, F.; Dionne, R.

2017-02-01

A CW kilowatt fiber laser numerical model has been developed taking into account intracavity stimulated Raman scattering (SRS). It uses the split-step Fourier method which is applied iteratively over several cavity round trips. The gain distribution is re-evaluated after each iteration with a standard CW model using an effective FBG reflectivity that quantifies the non-linear spectral leakage. This model explains why spectrally narrow output couplers produce more SRS than wider FBGs, as recently reported by other authors, and constitute a powerful tool to design optimized and innovative fiber components to push back the onset of SRS for a given fiber core diameter.

Design study of low-energy beam transport for multi-charge beams at RAON

NASA Astrophysics Data System (ADS)

Bahng, Jungbae; Qiang, Ji; Kim, Eun-San

2015-12-01

The Rare isotope Accelerator Of Newness (RAON) at the Rare Isotope Science Project (RISP) is being designed to simultaneously accelerate beams with multiple charge states. It includes a driver superconducting (SC) linac for producing 200 MeV/u and 400 kW continuous wave (CW) heavy ion beams from protons to uranium. The RAON consists of a few electron cyclotron resonance ion sources, a low-energy beam transport (LEBT) system, a CW 81.25 MHz, 500 keV/u radio frequency quadrupole (RFQ) accelerator, a medium-energy beam transport system, the SC linac, and a charge-stripper system. The LEBT system for the RISP accelerator facility consists of a high-voltage platform, two 90° dipoles, a multi-harmonic buncher (MHB), solenoids, electrostatic quadrupoles, a velocity equalizer, and a diagnostic system. The ECR ion sources are located on a high-voltage platform to reach an initial beam energy of 10 keV/u. After extraction, the ion beam is transported through the LEBT system to the RFQ accelerator. The generated charge states are selected by an achromatic bending system and then bunched by the MHB in the LEBT system. The MHB is used to achieve a small longitudinal emittance in the RFQ by generating a sawtooth wave with three harmonics. In this paper, we present the results and issues of the beam dynamics of the LEBT system.

Optically stimulated luminescence of natural NaCl mineral from Dead Sea exposed to gamma radiation.

PubMed

Roman-Lopez, J; Piña López, Y I; Cruz-Zaragoza, E; Marcazzó, J

2018-08-01

In this work, the continuous wave - optically stimulated luminescence (CW-OSL) emissions of natural salt minerals, collected from Dead Sea in summer of 2015, were studied. The CW-OSL dose response of natural salt showed a linear range between 0.5Gy and 10Gy of gamma radiation of 60 Co. Samples exposed at 3Gy exhibited good repeatability with a variation coefficient of 4.6%. The CW-OSL response as function of the preheating temperature (50-250°C) was analyzed. An increase of 15% of the CW-OSL response was observed in NaCl samples during storage period of 336h. The results showed that the natural Dead Sea salt minerals could be applied as natural dosimeter of gamma radiation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.

PubMed

Wang, Ging Kuo; Wang, Sho-Ya

2014-05-01

Lacosamide is an anticonvulsant hypothesized to enhance slow inactivation of neuronal Na(+) channels for its therapeutic action. Cardiac Na(+) channels display less and incomplete slow inactivation, but their sensitivity toward lacosamide remains unknown. We therefore investigated the action of lacosamide in human cardiac Nav1.5 and Nav1.5-CW inactivation-deficient Na(+) channels. Lacosamide showed little effect on hNav1.5 Na(+) currents at 300 µM when cells were held at -140 mV. With 30-second conditioning pulses from -90 to -50 mV; however, hNav1.5 Na(+) channels became sensitive to lacosamide with IC50 (50% inhibitory concentration) around 70-80 µM. Higher IC50 values were found at -110 and -30 mV. The development of lacosamide block at -70 mV was slow in wild-type Na(+) channels (τ; 8.04 ± 0.39 seconds, n = 8). This time constant was significantly accelerated in hNav1.5-CW inactivation-deficient counterparts. The recovery from lacosamide block at -70 mV for 10 seconds was relatively rapid in wild-type Na(+) channels (τ; 639 ± 90 milliseconds, n = 8). This recovery was accelerated further in hNav1.5-CW counterparts. Unexpectedly, lacosamide elicited a time-dependent block of persistent hNav1.5-CW Na(+) currents with an IC50 of 242 ± 19 µM (n = 5). Furthermore, both hNav1.5-CW/F1760K mutant and batrachotoxin-activated hNav1.5 Na(+) channels became completely lacosamide resistant, indicating that the lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin. Our results together suggest that lacosamide targets the intermediate preopen and open states of hNav1.5 Na(+) channels. Lacosamide may thus track closely the conformational changes at the hNav1.5-F1760 region along the activation pathway.

Block of Human Cardiac Sodium Channels by Lacosamide: Evidence for Slow Drug Binding along the Activation Pathway

PubMed Central

Wang, Sho-Ya

2014-01-01

Lacosamide is an anticonvulsant hypothesized to enhance slow inactivation of neuronal Na+ channels for its therapeutic action. Cardiac Na+ channels display less and incomplete slow inactivation, but their sensitivity toward lacosamide remains unknown. We therefore investigated the action of lacosamide in human cardiac Nav1.5 and Nav1.5-CW inactivation-deficient Na+ channels. Lacosamide showed little effect on hNav1.5 Na+ currents at 300 µM when cells were held at −140 mV. With 30-second conditioning pulses from −90 to −50 mV; however, hNav1.5 Na+ channels became sensitive to lacosamide with IC50 (50% inhibitory concentration) around 70–80 µM. Higher IC50 values were found at −110 and −30 mV. The development of lacosamide block at −70 mV was slow in wild-type Na+ channels (τ; 8.04 ± 0.39 seconds, n = 8). This time constant was significantly accelerated in hNav1.5-CW inactivation-deficient counterparts. The recovery from lacosamide block at −70 mV for 10 seconds was relatively rapid in wild-type Na+ channels (τ; 639 ± 90 milliseconds, n = 8). This recovery was accelerated further in hNav1.5-CW counterparts. Unexpectedly, lacosamide elicited a time-dependent block of persistent hNav1.5-CW Na+ currents with an IC50 of 242 ± 19 µM (n = 5). Furthermore, both hNav1.5-CW/F1760K mutant and batrachotoxin-activated hNav1.5 Na+ channels became completely lacosamide resistant, indicating that the lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin. Our results together suggest that lacosamide targets the intermediate preopen and open states of hNav1.5 Na+ channels. Lacosamide may thus track closely the conformational changes at the hNav1.5-F1760 region along the activation pathway. PMID:24563546

Linear Discriminant Analysis on a Spreadsheet.

ERIC Educational Resources Information Center

Busbey, Arthur Bresnahan III

1989-01-01

Described is a software package, "Trapeze," within which a routine called LinDis can be used. Discussed are teaching methods, the linear discriminant model and equations, the LinDis worksheet, and an example. The set up for this routine is included. (CW)

Cosmic Rays: "A Thin Rain of Charged Particles."

ERIC Educational Resources Information Center

Friedlander, Michael

1990-01-01

Discussed are balloons and electroscopes, understanding cosmic rays, cosmic ray paths, isotopes and cosmic-ray travel, sources of cosmic rays, and accelerating cosmic rays. Some of the history of the discovery and study of cosmic rays is presented. (CW)

RF Couplers for Normal-Conducting Photoinjector of High-Power CW FEL

NASA Astrophysics Data System (ADS)

Kurennoy, Sergey; Schrage, Dale; Wood, Richard; Schultheiss, Tom; Rathke, John; Young, Lloyd

2004-05-01

A high-current emittance-compensated RF photoinjector is a key enabling technology for a high-power CW FEL. A preliminary design of a normal-conducting, 2.5-cell pi-mode, 700-MHz CW RF photoinjector that will be build for demonstration purposes, is completed. This photoinjector will be capable of accelerating a 100-mA electron beam (3 nC per bunch at 35 MHz bunch repetition rate) to 2.7 MeV while providing an emittance below 7 mm-mrad at the wiggler. More than 1 MW of RF power will be fed into the photoinjector cavity through two ridge-loaded tapered waveguides. The waveguides are coupled to the cavity by "dog-bone" irises cut in a thick wall. Due to CW operation of the photoinjector, the cooling of the coupler irises is a rather challenging thermal management project. This paper presents results of a detailed electromagnetic modeling of the coupler-cavity system, which has been performed to select the coupler design that minimizes the iris heating due to RF power loss in its walls.

Generation of 14  W at 589  nm by frequency doubling of high-power CW linearly polarized Raman fiber laser radiation in MgO:sPPLT crystal.

PubMed

Surin, A A; Borisenko, T E; Larin, S V

2016-06-01

We introduce an efficient, single-mode, linearly polarized continuous wave (CW) Raman fiber laser (RFL), operating at 1178 nm, with 65 W maximum output power and a narrow linewidth of 0.1 nm. Single-pass second-harmonic generation was demonstrated using a 20 mm long MgO-doped stoichiometric periodically polled lithium tantalate (MgO:sPPLT) crystal pumped by RFL radiation. Output power of 14 W at 589 nm with 22% conversion efficiency was achieved. The possibility of further power scaling is considered, as no crystal degradation was observed at these power levels.

Heavy ion linear accelerator for radiation damage studies of materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.

A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response ofmore » the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for U-238(50+) and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.« less

Heavy ion linear accelerator for radiation damage studies of materials

NASA Astrophysics Data System (ADS)

Kutsaev, Sergey V.; Mustapha, Brahim; Ostroumov, Peter N.; Nolen, Jerry; Barcikowski, Albert; Pellin, Michael; Yacout, Abdellatif

2017-03-01

A new eXtreme MATerial (XMAT) research facility is being proposed at Argonne National Laboratory to enable rapid in situ mesoscale bulk analysis of ion radiation damage in advanced materials and nuclear fuels. This facility combines a new heavy-ion accelerator with the existing high-energy X-ray analysis capability of the Argonne Advanced Photon Source. The heavy-ion accelerator and target complex will enable experimenters to emulate the environment of a nuclear reactor making possible the study of fission fragment damage in materials. Material scientists will be able to use the measured material parameters to validate computer simulation codes and extrapolate the response of the material in a nuclear reactor environment. Utilizing a new heavy-ion accelerator will provide the appropriate energies and intensities to study these effects with beam intensities which allow experiments to run over hours or days instead of years. The XMAT facility will use a CW heavy-ion accelerator capable of providing beams of any stable isotope with adjustable energy up to 1.2 MeV/u for 238U50+ and 1.7 MeV for protons. This energy is crucial to the design since it well mimics fission fragments that provide the major portion of the damage in nuclear fuels. The energy also allows damage to be created far from the surface of the material allowing bulk radiation damage effects to be investigated. The XMAT ion linac includes an electron cyclotron resonance ion source, a normal-conducting radio-frequency quadrupole and four normal-conducting multi-gap quarter-wave resonators operating at 60.625 MHz. This paper presents the 3D multi-physics design and analysis of the accelerating structures and beam dynamics studies of the linac.

Precision CW laser automatic tracking system investigated

NASA Technical Reports Server (NTRS)

Lang, K. T.; Lucy, R. F.; Mcgann, E. J.; Peters, C. J.

1966-01-01

Precision laser tracker capable of tracking a low acceleration target to an accuracy of about 20 microradians rms is being constructed and tested. This laser tracking has the advantage of discriminating against other optical sources and the capability of simultaneously measuring range.

Field Emission in Superconducting Accelerators: Instrumented Measurements for Its Understanding and Mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geng, Rongli; Freyberger, Arne P.; Legg, Robert A.

Several new accelerator projects are adopting superconducting accelerator technology. When accelerating cavities maintain high RF gradients, field emission, the emission of electrons from cavity walls, can occur and may impact operational cavity gradient, radiological environment via activated components, and reliability. In this talk, we will discuss instrumented measurements of field emission from the two 1.1 GeV superconducting continuous wave (CW) linacs in CEBAF. The goal is to improve the understanding of field emission sources originating from cryomodule production, installation and operation. Such basic knowledge is needed in guiding field emission control, mitigation, and reduction toward high gradient and reliable operationmore » of superconducting accelerators.« less

Design study of a radio-frequency quadrupole for high-intensity beams

NASA Astrophysics Data System (ADS)

Bahng, Jungbae; Kim, Eun-San; Choi, Bong-Hyuk

2017-07-01

The Rare isotope Accelerator Of Newness (RAON) heavy-ion accelerator has been designed for the Rare Isotope Science Project (RISP) in Korea. The RAON will produce heavy-ion beams from 660-MeV-proton to 200-MeV/u-uranium with continuous wave (CW) power of 400 kW to support research in various scientific fields. Its system consists of an ECR ion source, LEBTs with 10 keV/u, CW RFQ accelerator with 81.25 MHz and 500 keV/u, a MEBT system, and a SC linac. In detail, the driver linac system consists of a Quarter Wave Resonator (QWR) section with 81.25 MHz and a Half Wave Resonator (HWR) section with 162.5 MHz, Linac-1, and a Spoke Cavity section with 325 MHz, Linac-2. These linacs have been designed to optimize the beam parameters to meet the required design goals. At the same time, a light-heavy ion accelerator with high-intensity beam, such as proton, deuteron, and helium beams, is required for experiments. In this paper, we present the design study of the high intensity RFQ for a deuteron beam with energies from 30 keV/u to 1.5 MeV/u and currents in the mA range. This system is composed of an Penning Ionization Gauge ion source, short LEBT with a RF deflector, and shared SC Linac. In order to increase acceleration efficiency in a short length with low cost, the 2nd harmonic of 162.5 MHz is applied as the operation frequency in the D+ RFQ design. The D+ RFQ is designed with 4.97 m, 1.52 bravery factor. Since it operates with 2nd harmonic frequency, the beam should be 50% of the duty factor while the cavity should be operated in CW mode, to protect the downstream linac system. We focus on avoiding emittance growth by the space-charge effect and optimizing the RFQ to achieve a high transmission and low emittance growth. Both the RFQ beam dynamics study and RFQ cavity design study for two and three dimensions will be discussed. Supported by Korea University Future Research Grant

Longitudinal driver model and collision warning and avoidance algorithms based on human driving databases

NASA Astrophysics Data System (ADS)

Lee, Kangwon

Intelligent vehicle systems, such as Adaptive Cruise Control (ACC) or Collision Warning/Collision Avoidance (CW/CA), are currently under development, and several companies have already offered ACC on selected models. Control or decision-making algorithms of these systems are commonly evaluated under extensive computer simulations and well-defined scenarios on test tracks. However, they have rarely been validated with large quantities of naturalistic human driving data. This dissertation utilized two University of Michigan Transportation Research Institute databases (Intelligent Cruise Control Field Operational Test and System for Assessment of Vehicle Motion Environment) in the development and evaluation of longitudinal driver models and CW/CA algorithms. First, to examine how drivers normally follow other vehicles, the vehicle motion data from the databases were processed using a Kalman smoother. The processed data was then used to fit and evaluate existing longitudinal driver models (e.g., the linear follow-the-leader model, the Newell's special model, the nonlinear follow-the-leader model, the linear optimal control model, the Gipps model and the optimal velocity model). A modified version of the Gipps model was proposed and found to be accurate in both microscopic (vehicle) and macroscopic (traffic) senses. Second, to examine emergency braking behavior and to evaluate CW/CA algorithms, the concepts of signal detection theory and a performance index suitable for unbalanced situations (few threatening data points vs. many safe data points) are introduced. Selected existing CW/CA algorithms were found to have a performance index (geometric mean of true-positive rate and precision) not exceeding 20%. To optimize the parameters of the CW/CA algorithms, a new numerical optimization scheme was developed to replace the original data points with their representative statistics. A new CW/CA algorithm was proposed, which was found to score higher than 55% in the performance index. This dissertation provides a model of how drivers follow lead-vehicles that is much more accurate than other models in the literature. Furthermore, the data-based approach was used to confirm that a CW/CA algorithm utilizing lead-vehicle braking was substantially more effective than existing algorithms, leading to collision warning systems that are much more likely to contribute to driver safety.

Study and development of CW room temperature rebuncher for SARAF accelerator

NASA Astrophysics Data System (ADS)

Kaizer, B.; Rodnizki, J.; Farber, E.; Perry, A.; Danon, L.; Horvitz, Z.; Mazor, O.; Friedman, A.; Di Giacomo, M.; Leyge, J.-F.; Michel, M.; Toussaint, P.

2017-11-01

The SARAF 176 MHz accelerator is designed to provide CW proton/deuteron beams up to 5 mA current and 40 MeV accelerated ion energy. Phase I of SARAF (up to 4-5 MeV) has been installed, commissioned, and is available for experimental work. Phase II of SARAF is currently in the design and first prototyping stage and will contain longer MEBT with three rebunchers and four cryomodules, each consisting of SC HWRs and solenoids. Phase II MEBT line is designed to follow a 1.3 MeV/u RFQ, is 4.5 m long, and contains three 176 MHz rebunchers providing a field integral of 105 kV. Different rebuncher configurations have been studied in order to minimize the RF losses and maximize the shunt impedance. Different apertures have also been tested with the 40 mm diameter required by beam dynamics. The simulations were done using CST Microwave Studio. CEA leads the design for SARAF phase II linac including the MEBT rebunchers and has studied a mixed solid copper and Cu plated stainless steel, 3-gap cavity. SNRC is developing a 4-gap OFHC copper rebuncher as a risk reduction. Both designs are presented and discussed in the paper.

Generation of an optical frequency comb with a Gaussian spectrum using a linear time-to-space mapping system.

PubMed

Hisatake, Shintaro; Tada, Keiji; Nagatsuma, Tadao

2010-03-01

We demonstrate the generation of an optical frequency comb (OFC) with a Gaussian spectrum using a continuous-wave (CW) laser, based on spatial convolution of a slit and a periodically moving optical beam spot in a linear time-to-space mapping system. A CW optical beam is linearly mapped to a spatial signal using two sinusoidal electro-optic (EO) deflections and an OFC is extracted by inserting a narrow spatial slit in the Fourier-transform plane of a second EO deflector (EOD). The spectral shape of the OFC corresponds to the spatial beam profile in the near-field region of the second EOD, which can be manipulated by a spatial filter without spectral dispersers. In a proof-of-concept experiment, a 16.25-GHz-spaced, 240-GHz-wide Gaussian-envelope OFC (corresponding to 1.8 ps Gaussian pulse generation) was demonstrated.

Improved Ablation Resistance of Silicone Rubber Composites by Introducing Montmorillonite and Silicon Carbide Whisker

PubMed Central

Zhang, Guangwu; Wang, Fuzhong; Huang, Zhixiong; Dai, Jing; Shi, Minxian

2016-01-01

Montmorillonite (MMT) was added to silicone rubber (SR) to improve the ablation resistance of the silicone. Following this, different quantities of silicon carbide whiskers (SiCw) were incorporated into the MMT/SR to yield a hybrid, ablative composite. The tensile strength and elongation at break of the composite increased after the addition of MMT. The ablation test results showed that MMT helped to form a covering layer by bonding with the silica and other components on the ablated surface. The linear and mass ablation rates exhibited decreases of 22.5% and 18.2%, respectively, in comparison to a control sample. After further incorporation of SiCw as the second filler, the resulting composites exhibited significantly higher tensile strength and ablation resistance, but not particularly lower elongation at break in comparison to the control sample. The SiCw/MMT fillers were beneficial in forming a dense and compact covering layer that delayed the heat and oxygen diffusion into the inner layers, which improved the ablation properties effectively. The remaining whiskers acted as a micro skeleton to maintain the composite’s char strength. Compared to the control sample, the linear and mass ablation rates of the composite after incorporating 6 phr SiCw and 10 phr MMT decreased by 59.2% and 43.6%, respectively. These experimental results showed that the fabricated composites exhibited outstanding mechanical properties and excellent ablation resistance. PMID:28773846

Improved Ablation Resistance of Silicone Rubber Composites by Introducing Montmorillonite and Silicon Carbide Whisker.

PubMed

Zhang, Guangwu; Wang, Fuzhong; Huang, Zhixiong; Dai, Jing; Shi, Minxian

2016-08-24

Montmorillonite (MMT) was added to silicone rubber (SR) to improve the ablation resistance of the silicone. Following this, different quantities of silicon carbide whiskers (SiCw) were incorporated into the MMT/SR to yield a hybrid, ablative composite. The tensile strength and elongation at break of the composite increased after the addition of MMT. The ablation test results showed that MMT helped to form a covering layer by bonding with the silica and other components on the ablated surface. The linear and mass ablation rates exhibited decreases of 22.5% and 18.2%, respectively, in comparison to a control sample. After further incorporation of SiCw as the second filler, the resulting composites exhibited significantly higher tensile strength and ablation resistance, but not particularly lower elongation at break in comparison to the control sample. The SiCw/MMT fillers were beneficial in forming a dense and compact covering layer that delayed the heat and oxygen diffusion into the inner layers, which improved the ablation properties effectively. The remaining whiskers acted as a micro skeleton to maintain the composite's char strength. Compared to the control sample, the linear and mass ablation rates of the composite after incorporating 6 phr SiCw and 10 phr MMT decreased by 59.2% and 43.6%, respectively. These experimental results showed that the fabricated composites exhibited outstanding mechanical properties and excellent ablation resistance.

Ultra-large core birefringent Yb-doped tapered double clad fiber for high power amplifiers.

PubMed

Fedotov, Andrey; Noronen, Teppo; Gumenyuk, Regina; Ustimchik, Vasiliy; Chamorovskii, Yuri; Golant, Konstantin; Odnoblyudov, Maxim; Rissanen, Joona; Niemi, Tapio; Filippov, Valery

2018-03-19

We present a birefringent Yb-doped tapered double-clad fiber with a record core diameter of 96 µm. An impressive gain of over 38 dB was demonstrated for linearly polarized CW and pulsed sources at a wavelength of 1040 nm. For the CW regime the output power was70 W. For a mode-locked fiber laser a pulse energy of 28 µJ with 292 kW peak power was reached at an average output power of 28 W for a 1 MHz repetition rate. The tapered double-clad fiber has a high value of polarization extinction ratio at 30 dB and is capable of delivering the linearly polarized diffraction-limited beam (M 2 = 1.09).

Design of a CW high charge state heavy ion RFQ for SSC-LINAC

NASA Astrophysics Data System (ADS)

Liu, G.; Lu, Y. R.; He, Y.; Wang, Z.; Xiao, C.; Gao, S. L.; Yang, Y. Q.; Zhu, K.; Yan, X. Q.; Chen, J. E.; Yuan, Y. J.; Zhao, H. W.

2013-02-01

The new linac injector SSC-LINAC has been proposed to replace the existing Separator Sector Cyclotron (SSC). This effort is to improve the beam efficiency of the Heavy Ion Research Facility of Lanzhou (HIRFL). As a key component of the linac, a continuous-wave (CW) mode high charge state heavy ion radio-frequency quadrupole (RFQ) accelerator has been designed. It accelerates ions with the ratio of mass to charge up to 7 from 3.728 keV/u to 143 keV/u. The requirements of CW mode operation and the transportation of intense beam have been considered as the greatest challenges. The design is based on 238U34+ beams, whose current is 0.5 pmA (0.5 particle mili-ampere, which is the measured 17 emA electric current divided by charge state of heavy ions). It achieves the transmission efficiency of 94% with 2508.46 mm long vanes in simulation. To improve the transmission efficiency and quality of the beams, the phase advance has been taken into account to analyze the reasons of beam loss and emittance growth. Parametric resonance and beam mismatch have been carefully avoided by adjusting the structure parameters. The parameter-sensitivity of the design is checked by transportation simulations of various input beams. To verify the applicability of machining, the effects of different vane manufacturing methods on beam dynamics are presented in this paper.

Direct sampling of chemical weapons in water by photoionization mass spectrometry.

PubMed

Syage, Jack A; Cai, Sheng-Suan; Li, Jianwei; Evans, Matthew D

2006-05-01

The vulnerability of water supplies to toxic contamination calls for fast and effective means for screening water samples for multiple threats. We describe the use of photoionization (PI) mass spectrometry (MS) for high-speed, high-throughput screening and molecular identification of chemical weapons (CW) threats and other hazardous compounds. The screening technology can detect a wide range of compounds at subacute concentrations with no sample preparation and a sampling cycle time of approximately 45 s. The technology was tested with CW agents VX, GA, GB, GD, GF, HD, HN1, and HN3, in addition to riot agents and precursors. All are sensitively detected and give simple PI mass spectra dominated by the parent ion. The target application of the PI MS method is as a routine, real-time early warning system for CW agents and other hazardous compounds in air and in water. In this work, we also present comprehensive measurements for water analysis and report on the system detection limits, linearity, quantitation accuracy, and false positive (FP) and false negative rates for concentrations at subacute levels. The latter data are presented in the form of receiver operating characteristic curves of the form of detection probability P(D) versus FP probability P(FP). These measurements were made using the CW surrogate compounds, DMMP, DEMP, DEEP, and DIMP. Method detection limits (3sigma) obtained using a capillary injection method yielded 1, 6, 3, and 2 ng/mL, respectively. These results were obtained using 1-microL injections of water samples without any preparation, corresponding to mass detection limits of 1, 6, 3, and 2 pg, respectively. The linear range was about 3-4 decades and the dynamic range about 4-5 decades. The relative standard deviations were generally <10% at CW subacute concentrations levels.

Diode-pumped quasi-three-level CW Nd:CLNGG and Nd:CNGG lasers.

PubMed

He, Kunna; Wei, Zhiyi; Li, Dehua; Zhang, Zhiguo; Zhang, Huaijin; Wang, Jiyang; Gao, Chunqing

2009-10-12

We have demonstrated what is to our knowledge the first quasi-three-level CW Nd:CLNGG laser with simple linear resonator. When the pump power was 18.2 W, a maximum output power of 1.63 W was obtained at the dual-wavelength of 935 nm and 928 nm. The optical-to-optical conversion efficiency was 9.0% and the slope efficiency was 11.5%. Lasing characteristics of a quasi-three-level CW Nd:CNGG laser were also investigated. A maximum output power of 1.87 W was obtained at the single-wavelength of 935 nm with 15.2 W pump power, corresponding to an optical-to-optical conversion efficiency of 12.3% and a slope efficiency of 15.6%.

Microstructure Evolution During Creep of Cold Worked Austenitic Stainless Steel

NASA Astrophysics Data System (ADS)

Krishan Yadav, Hari; Ballal, A. R.; Thawre, M. M.; Vijayanand, V. D.

2018-04-01

The 14Cr–15Ni austenitic stainless steel (SS) with additions of Ti, Si, and P has been developed for their superior creep strength and better resistance to void swelling during service as nuclear fuel clad and wrapper material. Cold working induces defects such as dislocations that interact with point defects generated by neutron irradiation and facilitates recombination to make the material more resistant to void swelling. In present investigation, creep properties of the SS in mill annealed condition (CW0) and 40 % cold worked (CW4) condition were studied. D9I stainless steel was solution treated at 1333 K for 30 minutes followed by cold rolling. Uniaxial creep tests were performed at 973 K for various stress levels ranging from 175-225 MPa. CW4 samples exhibited better creep resistance as compared to CW0 samples. During creep exposure, cold worked material exhibited phenomena of recovery and recrystallization wherein new strain free grains were observed with lesser dislocation network. In contrast CW0 samples showed no signs of recovery and recrystallization after creep exposure. Partial recrystallization on creep exposure led to higher drop in hardness in cold worked sample as compared to that in mill annealed sample. Accelerated precipitation of carbides at the grain boundaries was observed during creep exposure and this phenomenon was more pronounced in cold worked sample.

Role of algal biofilm in improving the performance of free surface, up-flow constructed wetland.

PubMed

Badhe, Neha; Saha, Shaswati; Biswas, Rima; Nandy, Tapas

2014-10-01

The role of algal biofilm in a pilot-scale, free-surface, up-flow constructed wetland (CW), was studied for its effect on chemical oxygen demand (COD), ammonia and phosphate removal during three seasons-autumn, winter and early spring. Effect of hydraulic retention time (HRT) was also investigated in presence and absence of algal biofilm. Principal Component Analysis was used to identify the independent factors governing the performance of CW. The study showed algal biofilm significantly improved nutrient removal, especially phosphate. Ammonia removal varied with HRT, biofilm and ambient temperature. Increase in biofilm thickness affected ammonia removal efficiency adversely. Algal biofilm-assisted COD removal compensated for reduced macrophyte density during winter. Two-way ANOVA test and the coefficients of dependent factors derived through multiple linear regression model confirmed role of algal biofilm in improving nutrient removal in CW. The study suggests that algal biofilm can be a green solution for bio-augmenting COD and nutrient removal in CW. Copyright © 2014 Elsevier Ltd. All rights reserved.

Estimation of Metal Acceleration by an SF5 Containing Explosive

DTIC Science & Technology

1991-06-30

cylinder wall acceleration, the wall energies for the baseline composition and for the composition CW2 were calculated by three different methods : KSM, 6...computaticno! method to calculate the cylinder energies needed for comparison with expermental data, it was decided to compare data from three known methods ...detonation pressure given for the GAB method in Reference 8. They are E(6mm) = 0.1272 (Isp X density)1 .5 - 0.021, and E(l9mm) = 0.1580 (Isp x density) 1 .5

Overtaking collision effects in a cw double-pass proton linac

DOE PAGES

Tao, Yue; Qiang, Ji; Hwang, Kilean

2017-12-22

The recirculating superconducting proton linac has the advantage of reducing the number of cavities in the accelerator and the corresponding construction and operational costs. Beam dynamics simulations were done recently in a double-pass recirculating proton linac using a single proton beam bunch. For continuous wave (cw) operation, the high-energy proton bunch during the second pass through the linac will overtake and collide with the low-energy bunch during the first pass at a number of locations of the linac. These collisions might cause proton bunch emittance growth and beam quality degradation. Here, we study the collisional effects due to Coulomb space-chargemore » forces between the high-energy bunch and the low-energy bunch. Our results suggest that these effects on the proton beam quality would be small and might not cause significant emittance growth or beam blowup through the linac. A 10 mA, 500 MeV cw double-pass proton linac is feasible without using extra hardware for phase synchronization.« less

Overtaking collision effects in a cw double-pass proton linac

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tao, Yue; Qiang, Ji; Hwang, Kilean

The recirculating superconducting proton linac has the advantage of reducing the number of cavities in the accelerator and the corresponding construction and operational costs. Beam dynamics simulations were done recently in a double-pass recirculating proton linac using a single proton beam bunch. For continuous wave (cw) operation, the high-energy proton bunch during the second pass through the linac will overtake and collide with the low-energy bunch during the first pass at a number of locations of the linac. These collisions might cause proton bunch emittance growth and beam quality degradation. Here, we study the collisional effects due to Coulomb space-chargemore » forces between the high-energy bunch and the low-energy bunch. Our results suggest that these effects on the proton beam quality would be small and might not cause significant emittance growth or beam blowup through the linac. A 10 mA, 500 MeV cw double-pass proton linac is feasible without using extra hardware for phase synchronization.« less

Interference susceptibility measurements for an MSK satellite communication link

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Fujikawa, Gene

1992-01-01

The results are presented of measurements of the degradation of an MSK satellite link due to modulated and CW (unmodulated) interference. These measurements were made using a hardware based satellite communication link simulator at NASA-Lewis. The results indicate the amount of bit error rate degradation caused by CW interference as a function of frequency and power level, and the degradation caused by adjacent channel and cochannel modulated interference as a function of interference power level. Results were obtained for both the uplink case (including satellite nonlinearity) and the downlink case (linear channel).

Process simulations for the LCLS-II cryogenic systems

NASA Astrophysics Data System (ADS)

Ravindranath, V.; Bai, H.; Heloin, V.; Fauve, E.; Pflueckhahn, D.; Peterson, T.; Arenius, D.; Bevins, M.; Scanlon, C.; Than, R.; Hays, G.; Ross, M.

2017-12-01

Linac Coherent Light Source II (LCLS-II), a 4 GeV continuous-wave (CW) superconducting electron linear accelerator, is to be constructed in the existing two mile Linac facility at the SLAC National Accelerator Laboratory. The first light from the new facility is scheduled to be in 2020. The LCLS-II Linac consists of thirty-five 1.3 GHz and two 3.9 GHz superconducting cryomodules. The Linac cryomodules require cryogenic cooling for the super-conducting niobium cavities at 2.0 K, low temperature thermal intercept at 5.5-7.5 K, and a thermal shield at 35-55 K. The equivalent 4.5 K refrigeration capacity needed for the Linac operations range from a minimum of 11 kW to a maximum of 24 kW. Two cryogenic plants with 18 kW of equivalent 4.5 K refrigeration capacity will be used for supporting the Linac cryogenic cooling requirements. The cryogenic plants are based on the Jefferson Lab’s CHL-II cryogenic plant design which uses the “Floating Pressure” design to support a wide variation in the cooling load. In this paper, the cryogenic process for the integrated LCLS-II cryogenic system and the process simulation for a 4.5 K cryoplant in combination with a 2 K cold compressor box, and the Linac cryomodules are described.

Heat transfer, thermal stress analysis and the dynamic behaviour of high power RF structures. [MARC and SUPERFISH codes

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKeown, J.; Labrie, J.P.

1983-08-01

A general purpose finite element computer code called MARC is used to calculate the temperature distribution and dimensional changes in linear accelerator rf structures. Both steady state and transient behaviour are examined with the computer model. Combining results from MARC with the cavity evaluation computer code SUPERFISH, the static and dynamic behaviour of a structure under power is investigated. Structure cooling is studied to minimize loss in shunt impedance and frequency shifts during high power operation. Results are compared with an experimental test carried out on a cw 805 MHz on-axis coupled structure at an energy gradient of 1.8 MeV/m.more » The model has also been used to compare the performance of on-axis and coaxial structures and has guided the mechanical design of structures suitable for average gradients in excess of 2.0 MeV/m at 2.45 GHz.« less

LCLS-II Cryomodules Production at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arkan, Tug; Grimm, Chuck; Kaluzny, Joshua

2017-05-01

LCLS-II is an upgrade project for the linear coherent light source (LCLS) at SLAC. The LCLS-II linac will consist of thirty-five 1.3 GHz and two 3.9 GHz superconducting RF continuous wave (CW) cryomodules that Fermilab and Jefferson Lab (JLab) will assemble in collaboration with SLAC. The LCLS-II 1.3 GHz cryomodule design is based on the European XFEL pulsed-mode cryomodule design with modifications needed for CW operation. Fermilab and JLab will each assemble and test a prototype 1.3 GHz cryomodule to assess the results of the CW modifications, in advance of 16 and 17 production 1.3 GHz cryomodules, respectively. Fermilab ismore » solely responsible for the 3.9 GHz cryomodules. After the prototype cryomodule tests are complete and lessons learned incorporated, both laboratories will increase their cryomodule production rates to meet the challenging LCLS-II project requirement of approximately one cryomodule per month per laboratory. This paper presents the Fermilab Cryomodule Assembly Facility (CAF) infrastructure for LCLS-II cryomodule production, the Fermilab prototype 1.3 GHz CW cryomodule (pCM) assembly and readiness for production assembly.« less

Design of spherical electron gun for ultra high frequency, CW power inductive output tube

NASA Astrophysics Data System (ADS)

Kaushik, Meenu; Joshi, L. M.

2016-03-01

Inductive Output Tube (IOT) is an amplifier that usually operates in UHF range. It is an electron tube whose basic structure is similar to conventional vacuum devices. This device is widely used in broadcast applications but is now being explored for scientific applications also specifically, particle accelerators and fusion plasma heating purposes. The paper describes the design approach of a spherical gridded electron gun of a 500 MHz, 100 kW CW power IOT. The electron gun structure has been simulated and optimized for operating voltage and current of 40kV and 3.5 A respectively. The electromagnetic analysis of this spherical electron gun has been carried out in CST and TRAK codes.

Design of spherical electron gun for ultra high frequency, CW power inductive output tube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaushik, Meenu, E-mail: mkceeri@gmail.com; Joshi, L. M., E-mail: lmj1953@gmail.com; Academy of Scientific and Innovative Research

Inductive Output Tube (IOT) is an amplifier that usually operates in UHF range. It is an electron tube whose basic structure is similar to conventional vacuum devices. This device is widely used in broadcast applications but is now being explored for scientific applications also specifically, particle accelerators and fusion plasma heating purposes. The paper describes the design approach of a spherical gridded electron gun of a 500 MHz, 100 kW CW power IOT. The electron gun structure has been simulated and optimized for operating voltage and current of 40kV and 3.5 A respectively. The electromagnetic analysis of this spherical electron gunmore » has been carried out in CST and TRAK codes.« less

Completely monolithic linearly polarized high-power fiber laser oscillator

NASA Astrophysics Data System (ADS)

Belke, Steffen; Becker, Frank; Neumann, Benjamin; Ruppik, Stefan; Hefter, Ulrich

2014-03-01

We have demonstrated a linearly polarized cw all-in-fiber oscillator providing 1 kW of output power and a polarization extinction ratio (PER) of up to 21.7 dB. The design of the laser oscillator is simple and consists of an Ytterbium-doped polarization maintaining large mode area (PLMA) fiber and suitable fiber Bragg gratings (FBG) in matching PLMA fibers. The oscillator has nearly diffraction-limited beam quality (M² < 1.2). Pump power is delivered via a high power 6+1:1 pump coupler. The slope efficiency of the laser is 75 %. The electro/optical efficiency of the complete laser system is ~30 % and hence in the range of Rofin's cw non-polarized fiber lasers. Choosing an adequate bending diameter for the Yb-doped PLMA fiber, one polarization mode as well as higher order modes are sufficiently supressed1. Resulting in a compact and robust linearly polarized high power single mode laser without external polarizing components. Linearly polarized lasers are well established for one dimensional cutting or welding applications. Using beam shaping optics radially polarized laser light can be generated to be independent from the angle of incident to the processing surface. Furthermore, high power linearly polarized laser light is fundamental for nonlinear frequency conversion of nonlinear materials.

Excitation of higher lying energy states in a rubidium DPAL

NASA Astrophysics Data System (ADS)

Wallerstein, A. J.; Perram, Glen; Rice, Christopher A.

2018-02-01

The spontaneous emission in a cw rubidium diode dumped alkali laser (DPAL) system was analyzed. The fluorescence from higher lying states decreases with additional buffer gas. The intermediate states (7S, 6P, 5D) decay more slowly with buffer gas and scale super-linearly with alkali density. A detailed kinetic model has been constructed, where the dominant mechanisms are energy pooling and single photon ionization. It also includes pumping into the non-Lorentzian wings of absorption profiles, fine structure mixing, collisional de-excitation, and Penning ionization. Effects of ionization in a high powered CW rubidium DPAL were assessed.

A laser based frequency modulated NL-OSL phenomenon

NASA Astrophysics Data System (ADS)

Mishra, D. R.; Bishnoi, A. S.; Soni, Anuj; Rawat, N. S.; Bhatt, B. C.; Kulkarni, M. S.; Babu, D. A. R.

2015-01-01

The detailed theoretical and experimental approach to novel technique of pulse frequency modulated stimulation (PFMS) method has been described for NL-OSL phenomenon. This method involved pulsed frequency modulation with respect to time for fixed pulse width of 532 nm continuous wave (CW)-laser light. The linearly modulated (LM)-, non-linearly (NL)-stimulation profiles have been generated using fast electromagnetic optical shutter. The PFMS parameters have been determined for present experimental setup. The PFMS based LM-, NL-OSL studies have been carried out on dosimetry grade single crystal α-Al2O3:C. The photo ionization cross section of α-Al2O3:C has been found to be ∼9.97 × 10-19 cm2 for 532 nm laser light using PFMS LM-OSL studies under assumption of first order of kinetic. This method of PFMS is found to be a potential alternative to generate different stimulation profiles using CW-light sources.

DOE Office of Scientific and Technical Information (OSTI.GOV)

J.K. Sekutowicz, P. Kneisel

This paper reports about our efforts to develop a flangeable coaxial coupler for both HOM and fundamental coupling for 9-cell TESLA/ILC-type cavities. The cavities were designed in early 90‘s for pulsed operation with a low duty factor, less than 1 %. The proposed design of the coupler has been done in a way, that the magnetic flux B at the flange connection is minimized and only a field of <5 mT would be present at the accelerating field Eacc of ~ 36 MV/m (B =150 mT in the cavity). Even though we achieved reasonably high Q-values at low field, themore » cavity/coupler combination was limited in the cw mode to only ~ 7 MV/m, where a thermally initiated degradation occurred. We have improved the cooling conditions by initially drilling radial channels every 30 degrees, then every 15 degrees into the shorting plate. The modified prototype performed well up to 9 MV/m in cw mode. This paper reports about our experiences with the further modified coaxial coupler and about test results in cw and low duty cycle pulsed mode, similar to the TESLA/ILC operation conditions.« less

Accelerators for Fusion Materials Testing

NASA Astrophysics Data System (ADS)

Knaster, Juan; Okumura, Yoshikazu

Fusion materials research is a worldwide endeavor as old as the parallel one working toward the long term stable confinement of ignited plasma. In a fusion reactor, the preservation of the required minimum thermomechanical properties of the in-vessel components exposed to the severe irradiation and heat flux conditions is an indispensable factor for safe operation; it is also an essential goal for the economic viability of fusion. Energy from fusion power will be extracted from the 14 MeV neutron freed as a product of the deuterium-tritium fusion reactions; thus, this kinetic energy must be absorbed and efficiently evacuated and electricity eventually generated by the conventional methods of a thermal power plant. Worldwide technological efforts to understand the degradation of materials exposed to 14 MeV neutron fluxes >1018 m-2s-1, as expected in future fusion power plants, have been intense over the last four decades. Existing neutron sources can reach suitable dpa (“displacement-per-atom”, the figure of merit to assess materials degradation from being exposed to neutron irradiation), but the differences in the neutron spectrum of fission reactors and spallation sources do not allow one to unravel the physics and to anticipate the degradation of materials exposed to fusion neutrons. Fusion irradiation conditions can be achieved through Li (d, xn) nuclear reactions with suitable deuteron beam current and energy, and an adequate flowing lithium screen. This idea triggered in the late 1970s at Los Alamos National Laboratory (LANL) a campaign working toward the feasibility of continuous wave (CW) high current linacs framed by the Fusion Materials Irradiation Test (FMIT) project. These efforts continued with the Low Energy Demonstrating Accelerator (LEDA) (a validating prototype of the canceled Accelerator Production of Tritium (APT) project), which was proposed in 2002 to the fusion community as a 6.7MeV, 100mA CW beam injector for a Li (d, xn) source to bridge with the International Fusion Materials Irradiation Facility (IFMIF) under discussion at the time. Worldwide technological efforts are maturing soundly and the time for a fusion-relevant neutron source has arrived according to world fusion roadmaps; if decisions are taken we could count the next decade with a powerful source of 14 MeV neutrons thanks to the expected significant results of the Engineering Validation and Engineering Design Activity (EVEDA) phase of the IFMIF project. The accelerator know-how has matured in all possible aspects since the times of FMIT conception in the 1970s; today, operating 125 mA deuteron beam at 40 MeV in CW with high availabilities seems feasible thanks to the understanding of the beam halo physics and the three main technological breakthroughs in accelerator technology: (1) the ECR ion source for light ions developed at Chalk River Laboratories in the early 1990s, (2) the RFQ operation of H+ in CW with 100 mA demonstrated by LEDA in LANL in the late 1990s, and (3) the growing maturity of superconducting resonators for light hadrons and low β beams achieved in recent years.

Accelerators for Fusion Materials Testing

NASA Astrophysics Data System (ADS)

Knaster, Juan; Okumura, Yoshikazu

Fusion materials research is a worldwide endeavor as old as the parallel one working toward the long term stable confinement of ignited plasma. In a fusion reactor, the preservation of the required minimum thermomechanical properties of the in-vessel components exposed to the severe irradiation and heat flux conditions is an indispensable factor for safe operation; it is also an essential goal for the economic viability of fusion. Energy from fusion power will be extracted from the 14 MeV neutron freed as a product of the deuterium-tritium fusion reactions; thus, this kinetic energy must be absorbed and efficiently evacuated and electricity eventually generated by the conventional methods of a thermal power plant. Worldwide technological efforts to understand the degradation of materials exposed to 14 MeV neutron fluxes > 1018 m-2s-1, as expected in future fusion power plants, have been intense over the last four decades. Existing neutron sources can reach suitable dpa ("displacement-per-atom", the figure of merit to assess materials degradation from being exposed to neutron irradiation), but the differences in the neutron spectrum of fission reactors and spallation sources do not allow one to unravel the physics and to anticipate the degradation of materials exposed to fusion neutrons. Fusion irradiation conditions can be achieved through Li (d, xn) nuclear reactions with suitable deuteron beam current and energy, and an adequate flowing lithium screen. This idea triggered in the late 1970s at Los Alamos National Laboratory (LANL) a campaign working toward the feasibility of continuous wave (CW) high current linacs framed by the Fusion Materials Irradiation Test (FMIT) project. These efforts continued with the Low Energy Demonstrating Accelerator (LEDA) (a validating prototype of the canceled Accelerator Production of Tritium (APT) project), which was proposed in 2002 to the fusion community as a 6.7MeV, 100mA CW beam injector for a Li (d, xn) source to bridge with the International Fusion Materials Irradiation Facility (IFMIF) under discussion at the time. Worldwide technological efforts are maturing soundly and the time for a fusion-relevant neutron source has arrived according to world fusion roadmaps; if decisions are taken we could count the next decade with a powerful source of 14 MeV neutrons thanks to the expected significant results of the Engineering Validation and Engineering Design Activity (EVEDA) phase of the IFMIF project. The accelerator know-how has matured in all possible aspects since the times of FMIT conception in the 1970s; today, operating 125 mA deuteron beam at 40 MeV in CW with high availabilities seems feasible thanks to the understanding of the beam halo physics and the three main technological breakthroughs in accelerator technology: (1) the ECR ion source for light ions developed at Chalk River Laboratories in the early 1990s, (2) the RFQ operation of H+ in CW with 100 mA demonstrated by LEDA in LANL in the late 1990s, and (3) the growing maturity of superconducting resonators for light hadrons and low β beams achieved in recent years.

Ultra-high vacuum photoelectron linear accelerator

DOEpatents

Yu, David U.L.; Luo, Yan

2013-07-16

An rf linear accelerator for producing an electron beam. The outer wall of the rf cavity of said linear accelerator being perforated to allow gas inside said rf cavity to flow to a pressure chamber surrounding said rf cavity and having means of ultra high vacuum pumping of the cathode of said rf linear accelerator. Said rf linear accelerator is used to accelerate polarized or unpolarized electrons produced by a photocathode, or to accelerate thermally heated electrons produced by a thermionic cathode, or to accelerate rf heated field emission electrons produced by a field emission cathode.

Eye safe high power laser diode in the 1410-1550nm range

NASA Astrophysics Data System (ADS)

Boucart, Julien; de Largy, Brian; Kearley, Mark; Lichtenstein, Norbert

2010-02-01

The demand for high power lasers emitting in the 14xx-15xxnm range is growing for applications in fields such as medical or homeland security. We demonstrate high power laser diodes with emission at 1430, 1470 and 1560 nm. Single multimode emitters at 1470nm emit about 3.5W in CW operation. Power conversion efficiency can reach values as high as 38.5%. With this base material, single and multi-emitter fiber coupled modules are built. Additionally, bars on passive and microchannel coolers are fabricated that deliver 25W and 38W respectively in CW mode, while obtaining more than 80 W in pulsed mode. All reliability tests show an outstanding stability of the material with no signs of wearout after 3750 hrs under strong acceleration conditions.

Enabling cost-effective high-current burst-mode operation in superconducting accelerators

DOE PAGES

Sheffield, Richard L.

2015-06-01

Superconducting (SC) accelerators are very efficient for CW or long-pulse operation, and normal conducting (NC) accelerators are cost effective for short-pulse operation. The addition of a short NC linac section to a SC linac can correct for the energy droop that occurs when pulsed high-current operation is required that exceeds the capability of the klystrons to replenish the cavity RF fields due to the long field fill-times of SC structures, or a requirement to support a broad range of beam currents results in variable beam loading. This paper describes the implementation of this technique to enable microseconds of high beam-current,more » 90 mA or more, in a 12 GeV SC long-pulse accelerator designed for the MaRIE 42-keV XFEL proposed for Los Alamos National Laboratory.« less

Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?

PubMed

Adair, Linda S; Martorell, Reynaldo; Stein, Aryeh D; Hallal, Pedro C; Sachdev, Harshpal S; Prabhakaran, Dorairaj; Wills, Andrew K; Norris, Shane A; Dahly, Darren L; Lee, Nanette R; Victora, Cesar G

2009-05-01

Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. We aimed to determine how birth weight (BW) and weight gain to midchildhood relate to blood pressure (BP) in young adults. We pooled data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa. We used conditional weight (CW), a residual of current weight regressed on prior weights, to represent deviations from expected weight gain from 0 to 12, 12 to 24, 24 to 48 mo, and 48 mo to adulthood. Adult BP and risk of prehypertension or hypertension (P/HTN) were modeled before and after adjustment for adult body mass index (BMI) and height. Interactions of CWs with small size-for-gestational age (SGA) at birth were tested. Higher CWs were associated with increased BP and odds of P/HTN, with coefficients proportional to the contribution of each CW to adult BMI. Adjusted for adult height and BMI, no child CW was associated with adult BP, but 1 SD of BW was related to a 0.5-mm Hg lower systolic BP and a 9% lower odds of P/HTN. BW and CW associations with systolic BP and P/HTN were not different between adults born SGA and those with normal BW, but higher CW at 48 mo was associated with higher diastolic BP in those born SGA. Greater weight gain at any age relates to elevated adult BP, but faster weight gains in infancy and young childhood do not pose a higher risk than do gains at other ages.

Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?123

PubMed Central

Martorell, Reynaldo; Stein, Aryeh D; Hallal, Pedro C; Sachdev, Harshpal S; Prabhakaran, Dorairaj; Wills, Andrew K; Norris, Shane A; Dahly, Darren L; Lee, Nanette R; Victora, Cesar G

2009-01-01

Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. Objective: We aimed to determine how birth weight (BW) and weight gain to midchildhood relate to blood pressure (BP) in young adults. Design: We pooled data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa. We used conditional weight (CW), a residual of current weight regressed on prior weights, to represent deviations from expected weight gain from 0 to 12, 12 to 24, 24 to 48 mo, and 48 mo to adulthood. Adult BP and risk of prehypertension or hypertension (P/HTN) were modeled before and after adjustment for adult body mass index (BMI) and height. Interactions of CWs with small size-for-gestational age (SGA) at birth were tested. Results: Higher CWs were associated with increased BP and odds of P/HTN, with coefficients proportional to the contribution of each CW to adult BMI. Adjusted for adult height and BMI, no child CW was associated with adult BP, but 1 SD of BW was related to a 0.5-mm Hg lower systolic BP and a 9% lower odds of P/HTN. BW and CW associations with systolic BP and P/HTN were not different between adults born SGA and those with normal BW, but higher CW at 48 mo was associated with higher diastolic BP in those born SGA. Conclusions: Greater weight gain at any age relates to elevated adult BP, but faster weight gains in infancy and young childhood do not pose a higher risk than do gains at other ages. PMID:19297457

Design, construction and evaluation of a 12.2 GHz, 4.0 kW-CW coupled-cavity traveling wave tube

NASA Technical Reports Server (NTRS)

Ayers, W. R.; Harman, W. A.

1973-01-01

An analytical and experimental program to study design techniques and to utilize these techniques to optimize the performance of an X-band 4 kW, CW traveling wave tube ultimately intended for satellite-borne television broadcast transmitters is described. The design is based on the coupled-cavity slow-wave circuit with velocity resynchronization to maximize the conversion efficiency. The design incorporates a collector which is demountable from the tube. This was done to facilitate multistage depressed collector experiments employing a NASA designed axisymmetric, electrostatic collector for linear beam microwave tubes after shipment of the tubes to NASA.

Multi-wavelength Yb:YAG/Nd³⁺:YVO₄ continuous-wave microchip Raman laser.

PubMed

Wang, Xiao-Lei; Dong, Jun; Wang, Xiao-Jie; Xu, Jie; Ueda, Ken-Ichi; Kaminskii, Alexander A

2016-08-01

Multi-wavelength continuous-wave (CW) Raman lasers in a laser diode pumped Yb:YAG/Nd³⁺:YVO₄ microchip Raman laser have been demonstrated for the first time to our best knowledge. The multi-wavelength laser of the first Stokes radiation around 1.08 μm has been achieved with a Raman shift of 261  cm^-1 for a-cut Nd:YVO₄ crystal corresponding to the fundamental wavelength at 1.05 μm. Multi-wavelength laser operation simultaneously around 1.05 and 1.08 μm has been achieved under the incident pump power between 1.5 and 1.7 W. Multi-wavelength Raman laser with frequency separation of 1 THz around 1.08 μm has been obtained when the incident pump power is higher than 1.7 W. The maximum Raman laser output power of 260 mW at 1.08 μm is obtained and the corresponding optical-to-optical conversion efficiency is 4.2%. Elliptically polarized fundamental laser and linearly polarized Raman laser were observed in an Yb:YAG/Nd:YVO₄ CW microchip Raman laser. The experimental results of linearly polarized, multi-wavelength Yb:YAG/Nd:YVO₄ CW microchip Raman laser with adjustable frequency separation provide a novel approach for developing potential compact laser sources for Terahertz generation.

Impact of cool-down conditions at Tc on the superconducting rf cavity quality factor

NASA Astrophysics Data System (ADS)

Vogt, J.-M.; Kugeler, O.; Knobloch, J.

2013-10-01

Many next-generation, high-gradient accelerator applications, from energy-recovery linacs to accelerator-driven systems (ADS) rely on continuous wave (CW) operation for which superconducting radio-frequency (SRF) systems are the enabling technology. However, while SRF cavities dissipate little power, they must be cooled by liquid helium and for many CW accelerators the complexity as well as the investment and operating costs of the cryoplant can prove to be prohibitive. We investigated ways to reduce the dynamic losses by improving the residual resistance (Rres) of niobium cavities. Both the material treatment and the magnetic shielding are known to have an impact. In addition, we found that Rres can be reduced significantly when the cool-down conditions during the superconducting phase transition of the niobium are optimized. We believe that not only do the cool-down conditions impact the level to which external magnetic flux is trapped in the cavity but also that thermoelectric currents are generated which in turn create additional flux that can be trapped. Therefore, we investigated the generation of flux and the dynamics of flux trapping and release in a simple model niobium-titanium system that mimics an SRF cavity in its helium tank. We indeed found that thermal gradients along the system during the superconducting transition can generate a thermoelectric current and magnetic flux, which subsequently can be trapped. These effects may explain the observed variation of the cavity’s Rres with cool-down conditions.

Direct current H- source for the medicine accelerator (invited)

NASA Astrophysics Data System (ADS)

Belchenko, Yu.; Savkin, V.

2004-05-01

A compact cw hydrogen negative ion source having reliable operation and a simplified maintenance is developed at Budker Institute of Nuclear Physics for a tandem accelerator of boron capture neutron therapy installation. The source uses a Penning discharge with a hydrogen and cesium feed through the hollows in the cathodes. Discharge voltage is about 60-80 V, current 9 A, hydrogen pressure 4-5 Pa, magnetic field 0.05-0.1 T, and cesium seed <1 mg/h. Negative ions are mainly produced on the cesiated anode surface due to conversion of hydrogen atoms. An optimal anode temperature is 250-350 °C. Negative ion beam current is directly proportional to the discharge current and to the emission hole area. A triode system for the beam extraction and acceleration system is used. The flux of accompanying extracted electrons was decreased by filtering in the transverse magnetic field. This electron flux was intercepted to the special electrode, biased at 4 kV potential with respect to the anode. Source stable cw operation for several hour runs was multiply tested. A H- ion beam with current up to 8 mA, beam energy 23 keV was produced regularly. Negative ion current of heavy impurities had a value of about 3% of the total beam current. Beam normalized emittance is about 0.3 π mm mrad and emission current density -0.1 A/cm2. A built-in cathode heater provides the operation quick start.

Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Vascular Endothelial Growth Factor with Dual-Labeled Bevacizumab.

PubMed

Zhang, Yin; Hong, Hao; Engle, Jonathan W; Yang, Yunan; Barnhart, Todd E; Cai, Weibo

2012-01-01

The pivotal role of vascular endothelial growth factor (VEGF) in cancer is underscored by the approval of bevacizumab (Bev, a humanized anti-VEGF monoclonal antibody) for first line treatment of cancer patients. The aim of this study was to develop a dual-labeled Bev for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging of VEGF. Bev was conjugated to a NIRF dye (i.e. 800CW) and 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA) before (64)Cu-labeling. Flow cytometry analysis of U87MG human glioblastoma cells revealed no difference in VEGF binding affinity/specificity between Bev and NOTA-Bev-800CW. (64)Cu-labeling of NOTA-Bev-800CW was achieved with high yield. Serial PET imaging of U87MG tumor-bearing female nude mice revealed that tumor uptake of (64)Cu-NOTA-Bev-800CW was 4.6 ± 0.7, 16.3 ± 1.6, 18.1 ± 1.4 and 20.7 ± 3.7 %ID/g at 4, 24, 48 and 72 h post-injection respectively (n = 4), corroborated by in vivo/ex vivo NIRF imaging and biodistribution studies. Tumor uptake as measured by ex vivo NIRF imaging had a good linear correlation with the %ID/g values obtained from PET (R(2) = 0.93). Blocking experiments and histology both confirmed the VEGF specificity of (64)Cu-NOTA-Bev-800CW. The persistent, prominent, and VEGF-specific uptake of (64)Cu-NOTA-Bev-800CW in the tumor, observed by both PET and NIRF imaging, warrants further investigation and future clinical translation of such Bev-based imaging agents.

Predictive performance of genomic selection methods for carcass traits in Hanwoo beef cattle: impacts of the genetic architecture.

PubMed

Mehrban, Hossein; Lee, Deuk Hwan; Moradi, Mohammad Hossein; IlCho, Chung; Naserkheil, Masoumeh; Ibáñez-Escriche, Noelia

2017-01-04

Hanwoo beef is known for its marbled fat, tenderness, juiciness and characteristic flavor, as well as for its low cholesterol and high omega 3 fatty acid contents. As yet, there has been no comprehensive investigation to estimate genomic selection accuracy for carcass traits in Hanwoo cattle using dense markers. This study aimed at evaluating the accuracy of alternative statistical methods that differed in assumptions about the underlying genetic model for various carcass traits: backfat thickness (BT), carcass weight (CW), eye muscle area (EMA), and marbling score (MS). Accuracies of direct genomic breeding values (DGV) for carcass traits were estimated by applying fivefold cross-validation to a dataset including 1183 animals and approximately 34,000 single nucleotide polymorphisms (SNPs). Accuracies of BayesC, Bayesian LASSO (BayesL) and genomic best linear unbiased prediction (GBLUP) methods were similar for BT, EMA and MS. However, for CW, DGV accuracy was 7% higher with BayesC than with BayesL and GBLUP. The increased accuracy of BayesC, compared to GBLUP and BayesL, was maintained for CW, regardless of the training sample size, but not for BT, EMA, and MS. Genome-wide association studies detected consistent large effects for SNPs on chromosomes 6 and 14 for CW. The predictive performance of the models depended on the trait analyzed. For CW, the results showed a clear superiority of BayesC compared to GBLUP and BayesL. These findings indicate the importance of using a proper variable selection method for genomic selection of traits and also suggest that the genetic architecture that underlies CW differs from that of the other carcass traits analyzed. Thus, our study provides significant new insights into the carcass traits of Hanwoo cattle.

2.5 MeV CW 4-vane RFQ accelerator design for BNCT applications

NASA Astrophysics Data System (ADS)

Zhu, Xiaowen; Wang, Hu; Lu, Yuanrong; Wang, Zhi; Zhu, Kun; Zou, Yubin; Guo, Zhiyu

2018-03-01

Boron Neutron Capture Therapy (BNCT) promises a bright future in cancer therapy for its highly selective destruction of cancer cells, using the 10B +n→7Li +4 He reaction. It offers a more satisfactory therapeutic effect than traditional methods for the treatment of malignant brain tumors, head and neck cancer, melanoma, liver cancer and so on. A CW 4-vane RFQ, operating at 162.5 MHz, provides acceleration of a 20 mA proton beam to 2.5 MeV, bombarding a liquid lithium target for neutron production with a soft neutron energy spectrum. The fast neutron yield is about 1.73×1013 n/s. We preliminarily develop and optimize a beam shaping assembly design for the 7Li(p, n)7Be reaction with a 2.5 MeV proton beam. The epithermal neutron flux simulated at the beam port will reach up to 1 . 575 ×109 n/s/cm2. The beam dynamics design, simulation and benchmark for 2.5 MeV BNCT RFQ have been performed with both ParmteqM (V3.05) and Toutatis, with a transmission efficiency higher than 99.6% at 20 mA. To ease the thermal management in the CW RFQ operation, we adopt a modest inter-vane voltage design (U = 65 kV), though this does increase the accelerator length (reaching 5.2 m). Using the well-developed 3D electromagnetic codes, CST MWS and ANSYS HFSS, we are able to deal with the complexity of the BNCT RFQ, taking the contribution of each component in the RF volume into consideration. This allows us to optimize the longitudinal field distribution in a full-length model. Also, the parametric modeling technique is of great benefit to extensive modifications and simulations. In addition, the resonant frequency tuning of this RFQ is studied, giving the tuning sensitivities of vane channel and wall channel as -16.3 kHz/°C and 12.4 kHz/°C, respectively. Finally, both the multipacting level of this RFQ and multipacting suppressing in the coaxial coupler are investigated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gündoğan, M. Tural, E-mail: mugetural@yahoo.com; Yavaş, Ö., E-mail: yavas@ankara.edu.tr; Kaya, Ç., E-mail: c.kaya@ankara.edu.tr

Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC.more » The design of the Button-type Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna design and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.« less

Secondary emission electron gun using external primaries

DOEpatents

Srinivasan-Rao, Triveni [Shoreham, NY; Ben-Zvi, Ilan [Setauket, NY

2009-10-13

An electron gun for generating an electron beam is provided, which includes a secondary emitter. The secondary emitter includes a non-contaminating negative-electron-affinity (NEA) material and emitting surface. The gun includes an accelerating region which accelerates the secondaries from the emitting surface. The secondaries are emitted in response to a primary beam generated external to the accelerating region. The accelerating region may include a superconducting radio frequency (RF) cavity, and the gun may be operated in a continuous wave (CW) mode. The secondary emitter includes hydrogenated diamond. A uniform electrically conductive layer is superposed on the emitter to replenish the extracted current, preventing charging of the emitter. An encapsulated secondary emission enhanced cathode device, useful in a superconducting RF cavity, includes a housing for maintaining vacuum, a cathode, e.g., a photocathode, and the non-contaminating NEA secondary emitter with the uniform electrically conductive layer superposed thereon.

Secondary emission electron gun using external primaries

DOEpatents

Srinivasan-Rao, Triveni [Shoreham, NY; Ben-Zvi, Ilan [Setauket, NY; Kewisch, Jorg [Wading River, NY; Chang, Xiangyun [Middle Island, NY

2007-06-05

An electron gun for generating an electron beam is provided, which includes a secondary emitter. The secondary emitter includes a non-contaminating negative-electron-affinity (NEA) material and emitting surface. The gun includes an accelerating region which accelerates the secondaries from the emitting surface. The secondaries are emitted in response to a primary beam generated external to the accelerating region. The accelerating region may include a superconducting radio frequency (RF) cavity, and the gun may be operated in a continuous wave (CW) mode. The secondary emitter includes hydrogenated diamond. A uniform electrically conductive layer is superposed on the emitter to replenish the extracted current, preventing charging of the emitter. An encapsulated secondary emission enhanced cathode device, useful in a superconducting RF cavity, includes a housing for maintaining vacuum, a cathode, e.g., a photocathode, and the non-contaminating NEA secondary emitter with the uniform electrically conductive layer superposed thereon.

A button - type beam position monitor design for TARLA facility

NASA Astrophysics Data System (ADS)

Gündoǧan, M. Tural; Kaya, ć.; Yavaş, Ö.

2016-03-01

Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC. The design of the Button-type Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna design and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.

On temporal dynamics of Sn2P2S6 oscillation in semi-linear cavity.

PubMed

Arciszewski, D; Shumelyuk, A; Odoulov, S

2013-06-01

Experimental measurements and calculations revealed an unusual type of oscillation dynamics of Sn(2)P(2)S(6) in the semi-linear cavity. It consists of a pronounced saw-tooth modulation of oscillation intensity--although it is not 100% in contrast--with the cw component being shifted in frequency with respect to the pump wave. This effect is attributed to the hybrid mode of two semi-linear oscillation geometries, one with a single pump wave and the other with two counterpropagating pump waves.

Compact diode-pumped continuous-wave and passively Q-switched Nd:GYSO laser at 1.07 μm

NASA Astrophysics Data System (ADS)

Lin, Zhi; Huang, Xiaoxu; Lan, Jinglong; Cui, Shengwei; Wang, Yi; Xu, Bin; Luo, Zhengqian; Xu, Huiying; Cai, Zhiping; Xu, Xiaodong; Zhang, Xiaoyan; Wang, Jun; Xu, Jun

2016-08-01

We report diode-pumped continuous-wave (CW) and Q-switched Nd:GYSO lasers using a compact two-mirror linear laser cavity. Single-wavelength laser emissions at 1074.11 nm with 4.1-W power and at 1058.27 nm with 1.47-W power have been obtained in CW mode. The slope efficiencies with respect to the absorbed pump powers are 48.5% and 22.9%, respectively. Wavelength tunability is also demonstrated with range of about 8 nm. Using a MoS2 saturable absorber, maximum average output power up to 410 mW at 1074 nm can be yielded with absorbed pump power 6.41 W and the maximum pulse energy reaches 1.20 μJ with pulse repetition rate of 342.5 kHz and shortest pulse width of 810 ns. The CW laser results represent the best laser performance and the Q-switching also present the highest output power for Q-switched Nd3+ lasers with MoS2 as saturable absorber.

Urinary carcinogenic 4-6 ring polycyclic aromatic hydrocarbons in coke oven workers and in subjects belonging to the general population: role of occupational and environmental exposure.

PubMed

Campo, Laura; Fustinoni, Silvia; Consonni, Dario; Pavanello, Sofia; Kapka, Lucyna; Siwinska, Ewa; Mielzyňska, Danuta; Bertazzi, PierAlberto

2014-03-01

A new solid phase microextraction-gas chromatography-mass spectrometry method (SPME-GC-MS) to detect urinary unmetabolized 3-, 6-ring polycyclic aromatic hydrocarbons (PAHs) was applied to coke oven workers and general population subjects with the aim to assess exposure to carcinogenic PAHs, to evaluate the role of occupational and environmental variables on PAHs levels, and to compare present results with those previously obtained with a less sensitive method. A total of 104 coke oven workers (CW) from Poland [recruited in 2000 (CW-2000; n=55) and 2006 (CW-2006; n=49)], and 45 control subjects from the same area, provided urine spot samples for measurement of 10 PAHs (from phenanthrene to benzo[g,h,i]perylene). The comparison between the two methods was performed only on CW-2000 subjects. Information regarding personal characteristics and job variables was collected by a questionnaire. The new method enables the quantification of 5-, 6-ring PAHs; precision and accuracy were in the 7.3-20.8% and 89.4-110% range, respectively; in CW-2000 samples results obtained with the new and the old method were highly correlated (Lin's concordance correlation coefficients: from 0.790 to 0.965); the mean difference between measured PAHS increased with the molecular weight of the analytes (from +5 to +27%). Urinary PAHs were above or equal to the quantification limit, depending on the compound, in 67-100% (min-max), 26-100% and 6-100% of samples from CW-2000, CW-2006 and controls, respectively. Chrysene and benz[a]anthracene were the most abundant carcinogenic PAHs with median levels of 43.4, 13.4, and 2.3 ng/L and 45.9, 14.9, and 0.7 ng/L in CW-2000, CW-2006, and controls, respectively, while benzo[a]pyrene levels were 6.5, 0.7 and <0.5 ng/L. The multiple linear regression model showed that the determinants of exposure were the use of wood and/or coke for house heating for controls, and job title or the plant for CW-2006. Urinary benzo[a]pyrene and other carcinogenic PAHs were, for the first time, quantified in urine samples from both occupationally and environmentally exposed subjects. These results show that urinary PAHs can discriminate exposure at different levels. Moreover, the simultaneous determination of several PAHs allows for the development of excretion profiles to assess exposure to specific compounds. Copyright © 2013 Elsevier GmbH. All rights reserved.

Superconducting traveling wave accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farkas, Z.D.

1984-11-01

This note considers the applicability of superconductivity to traveling wave accelerators. Unlike CW operation of a superconducting standing wave or circulating wave accelerator section, which requires improvement factors (superconductor conductivity divided by copper conductivity) of about 10/sup 6/ in order to be of practical use, a SUperconducting TRaveling wave Accelerator, SUTRA, operating in the pulsed mode requires improvement factors as low as about 10/sup 3/, which are attainable with niobium or lead at 4.2K, the temperature of liquid helium at atmospheric pressure. Changing from a copper traveling wave accelerator to SUTRA achieves the following. (1) For a given gradient SUTRAmore » reduces the peak and average power requirements typically by a factor of 2. (2) SUTRA reduces the peak power still further because it enables us to increase the filling time and thus trade pulse width for gradient. (3) SUTRA makes possible a reasonably long section at higher frequencies. (4) SUTRA makes possible recirculation without additional rf average power. 8 references, 6 figures, 1 table.« less

Single-grain growth in Si film by chevron-shaped cw laser beam scanning

NASA Astrophysics Data System (ADS)

Yeh, Wenchang; Yamazaki, Satoki; Ishimoto, Akihisa; Morito, Shigekazu

2016-02-01

A single grain with a length of 450 µm and a width of 5-6 µm was grown in a 60 nm Si film on SiO2 by scanning a chevron-shaped cw laser beam, which was formed by passing a linear laser beam through a novel one-sided Dove prism. The crystal did not have any dominant orientations in both the growth and normal directions. The orientation rotated about the transverse direction at a rate of 0.47-0.51°/µm in the forward direction, which suggests that the lattice constant at the film surface was 0.049-0.053% larger than that at the film bottom.

1-kilowatt CW all-fiber laser oscillator pumped with wavelength-beam-combined diode stacks.

PubMed

Xiao, Y; Brunet, F; Kanskar, M; Faucher, M; Wetter, A; Holehouse, N

2012-01-30

We have demonstrated a monolithic cladding-pumped ytterbium-doped single all-fiber laser oscillator generating 1 kW of CW signal power at 1080 nm with 71% slope efficiency and near diffraction-limited beam quality. Fiber components were highly integrated on "spliceless" passive fibers to promote laser efficiency and alleviate non-linear effects. The laser was pumped through a 7:1 pump combiner with seven 200-W 91x nm fiber-pigtailed wavelength-beam-combined diode-stack modules. The signal power of such a single all-fiber laser oscillator showed no evidence of roll-over, and the highest output was limited only by available pump power.

Optical limiting in gelatin stabilized Cu-PVP nanocomposite colloidal suspension

NASA Astrophysics Data System (ADS)

Tamgadge, Y. S.; Gedam, P. P.; Thakare, N. B.; Talwatkar, S. S.; Sunatkari, A. L.; Muley, G. G.

2018-05-01

This article illustrates investigations on optical limiting properties of Cu-PVP nanocomposite colloidal suspension. Gelatin stabilized Cu nanoparticles have been synthesized using chemical reduction method and thin films in PVP matrix have been obtained using spin coating technique. Thin films have been characterized by X-ray diffraction (XRD), Ultraviolet-visible (UV-vis) spectroscopy, etc. for structural and linear optical studies. Optical limiting properties of Colloidal Cu-PVP nanocomposites have been investigated at 808 nm diode CW laser. Minimum optical limiting threshold was found for GCu3-PVP nanocomposites sample. The strong optical limiting is thermal in origin as CW laser is used and effects are attributed to thermal lensing effect.

A Student Experiment to Demonstrate the Energy Loss and Straggling of Electrons in Matter.

ERIC Educational Resources Information Center

de Bruin, M.; Huijgen, F. W. J.

1990-01-01

Described is an introductory experiment that allows students to directly observe and measure the linear energy transfer in matter. Illustrated are the experimental setup including the radioactive source, electronic equipment, and the detector; measurement and calculations; and the results. (CW)

Optimal Control Strategies for Constrained Relative Orbits

DTIC Science & Technology

2007-09-01

the chief. The work assumes the Clohessy - Wiltshire closeness assump- tion between the deputy and chief is valid, however, elliptical chief orbits are...133 Appendix G. A Closed-Form Solution of the Linear Clohessy - Wiltshire Equa- tions...Counterspace . . . . . . . . . . . . . . . . . . . 1 CW Clohessy - Wiltshire . . . . . . . . . . . . . . . . . . . . . . 4 DARPA Defense Advanced Research

Laser induced white lighting of tungsten filament

NASA Astrophysics Data System (ADS)

Strek, W.; Tomala, R.; Lukaszewicz, M.

2018-04-01

The sustained bright white light emission of thin tungsten filament was induced under irradiation with focused beam of CW infrared laser diode. The broadband emission centered at 600 nm has demonstrated the threshold behavior on excitation power. Its intensity increased non-linearly with excitation power. The emission occurred only from the spot of focused beam of excitation laser diode. The white lighting was accompanied by efficient photocurrent flow and photoelectron emission which both increased non-linearly with laser irradiation power.

Asymmetry in the clockwise and counterclockwise rotation of the bacterial flagellar motor

PubMed Central

Yuan, Junhua; Fahrner, Karen A.; Turner, Linda; Berg, Howard C.

2010-01-01

Cells of Escherichia coli are able to swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, which spin alternately clockwise (CW) and counterclockwise (CCW). Rotation in either direction has been thought to be symmetric and exhibit the same torques and speeds. The relationship between torque and speed is one of the most important measurable characteristics of the motor, used to distinguish specific mechanisms of motor rotation. Previous measurements of the torque–speed relationship have been made with cells lacking the response regulator CheY that spin their motors exclusively CCW. In this case, the torque declines slightly up to an intermediate speed called the “knee speed” after which it falls rapidly to zero. This result is consistent with a “power-stroke” mechanism for torque generation. Here, we measure the torque–speed relationship for cells that express large amounts of CheY and only spin their motors CW. We find that the torque decreases linearly with speed, a result remarkably different from that for CCW rotation. We obtain similar results for wild-type cells by reexamining data collected in previous work. We speculate that CCW rotation might be optimized for runs, with higher speeds increasing the ability of cells to sense spatial gradients, whereas CW rotation might be optimized for tumbles, where the object is to change cell trajectories. But why a linear torque–speed relationship might be optimum for the latter purpose we do not know. PMID:20615986

Statistical study of the reliability of oxide-defined stripe cw lasers of (AlGa)As

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ettenberg, M.

1979-03-01

In this report, we describe a statistical study of the reliability of oxide-defined stripe-contact cw injection lasers of (AlGa)As. These devices have one facet coated with Al/sub 2/O/sub 3/ and one facet coated with an Al/sub 2/O/sub 3//Si dichroic reflector; the lasers are optimized for cw low-threshold currents at room temperature, with values typically about 50 mA. Lifetests were carried out at 70 /sup 0/C ambient, in the cw mode of operation with about 5 mW output. Previous lifetests showed that the degradation rate followed a 0.95-eV activation energy so the 70 /sup 0/C environment provides a degradation acceleration factormore » of 190 over that at room temperature. We have found that the device failures follow a log-normal distribution, characterized by a mean time before failure of 4200 h and a standard deviation of 1.3. This corresponds to a mean time to failure (MTTF) of 10/sup 6/ h at room temperature. Failure is defined here as the inability of the device to emit 1 mW of stimulated cw output at 70 /sup 0/C, and assumes that optical feedback will be employed to adjust the laser current during operation. If a constant-current drive is envisioned, the failures for a 3-dB drop in light output also follow a log-normal distribution with a similar slope (standard deviation=1.1) and a MTTF of 2000 h at 70 /sup 0/C (500 000 h at room temperature). The failures were found to be mainly due to bulk gradual degradation and not facet or contact failure. Careful study of lasers before and after lifetest showed a significant increase in contact thermal resistance. However, this increase accounts for only a small portion of the nearly 70% increase in room-temperature cw threshold after failure at 70 /sup 0/C. After failure at 70 /sup 0/C, we also noted a degradation in the near-field and associated far-field pattern of the laser.« less

Two-photon absorption in arsenic sulfide glasses

NASA Astrophysics Data System (ADS)

Chunaev, D. S.; Snopatin, G. E.; Plotnichenko, V. G.; Karasik, A. Ya.

2016-10-01

The two-photon absorption coefficient of 1047-{\\text{nm}} light in {\\text{As}}35{\\text{S}}65 chalcogenide glass has been measured. CW probe radiation has been used to observe the linear absorption in glass induced by two-photon excitation. The induced absorption lifetime was found to be ∼ 2 {\\text{ms}}.

RF structure design of the China Material Irradiation Facility RFQ

NASA Astrophysics Data System (ADS)

Li, Chenxing; He, Yuan; Xu, Xianbo; Zhang, Zhouli; Wang, Fengfeng; Dou, Weiping; Wang, Zhijun; Wang, Tieshan

2017-10-01

The radio frequency structure design of the radio frequency quadrupole (RFQ) for the front end of China Material Irradiation Facility (CMIF), which is an accelerator based neutron irradiation facility for fusion reactor material qualification, has been completed. The RFQ is specified to accelerate 10 mA continuous deuteron beams from the energies of 20 keV/u to 1.5 MeV/u within the vane length of 5250 mm. The working frequency of the RFQ is selected to 162.5 MHz and the inter-vane voltage is set to 65 kV. Four-vane cavity type is selected and the cavity structure is designed drawing on the experience of China Initiative Accelerator Driven System (CIADS) Injector II RFQ. In order to reduce the azimuthal asymmetry of the field caused from errors in fabrication and assembly, a frequency separation between the working mode and its nearest dipole mode is reached to 17.66 MHz by utilizing 20 pairs of π-mode stabilizing loops (PISLs) distributed along the longitudinal direction with equal intervals. For the purpose of tuning, 100 slug tuners were introduced to compensate the errors caused by machining and assembly. In order to obtain a homogeneous electrical field distribution along cavity, vane cutbacks are introduced and output endplate is modified. Multi-physics study of the cavity with radio frequency power and water cooling is performed to obtain the water temperature tuning coefficients. Through comparing to the worldwide CW RFQs, it is indicated that the power density of the designed structure is moderate for operation under continuous wave (CW) mode.

Remote Vibration Measurements at a Sud Aviation Alouette III Helicopter with a CW CO2-Laser System

DTIC Science & Technology

1993-09-28

mrad and a continuous output of 0.4 Watt. The purpose of our measurements was to measure the vibration spectra of a helicopter from the Dutch Air Force...detection 13 3.2.1 Non-linear effects in vibrometry 15 4 THE VIBRATION SOURCES OF A HELICOPTER 24 5 MEASUREMENTS 29 5.1 Measuring Method 29 5.2 Scenario...vibration in Hz. 3.2.1 Non-linear effects in vibrometry A brief explanation of the non-linear effects is given below. A FM receiver has a built-in limiter

Jefferson Lab 12 GEV Cebaf Upgrade

NASA Astrophysics Data System (ADS)

Rode, C. H.

2010-04-01

The existing continuous electron beam accelerator facility (CEBAF) at Thomas Jefferson National Accelerator Facility (TJNAF) is a 5-pass, recirculating cw electron Linac operating at ˜6 GeV and is devoted to basic research in nuclear physics. The 12 GeV CEBAF Upgrade is a 310 M project, sponsored by the Department of Energy (DOE) Office of Nuclear Physics, that will expand its research capabilities substantially by doubling the maximum energy and adding major new experimental apparatus. The project received construction approval in September 2008 and has started the major procurement process. The cryogenic aspects of the 12 GeV CEBAF Upgrade includes: doubling the accelerating voltages of the Linacs by adding ten new high-performance, superconducting radiofrequency (SRF) cryomodules (CMs) to the existing 42 1/4 cryomodules; doubling of the 2 K cryogenics plant; and the addition of eight superconducting magnets.

Linear beam dynamics and ampere class superconducting RF cavities at RHIC

NASA Astrophysics Data System (ADS)

Calaga, Rama R.

The Relativistic Heavy Ion Collider (RHIC) is a hadron collider designed to collide a range of ions from protons to gold. RHIC operations began in 2000 and has successfully completed five physics runs with several species including gold, deuteron, copper, and polarized protons. Linear optics and coupling are fundamental issues affecting the collider performance. Measurement and correction of optics and coupling are important to maximize the luminosity and sustain stable operation. A numerical approach, first developed at SLAC, was implemented to measure linear optics from coherent betatron oscillations generated by ac dipoles and recorded at multiple beam position monitors (BPMs) distributed around the collider. The approach is extended to a fully coupled 2D case and equivalence relationships between Hamiltonian and matrix formalisms are derived. Detailed measurements of the transverse coupling terms are carried out at RHIC and correction strategies are applied to compensate coupling both locally and globally. A statistical approach to determine BPM reliability and performance over the past three runs and future improvements also discussed. Aiming at a ten-fold increase in the average heavy-ion luminosity, electron cooling is the enabling technology for the next luminosity upgrade (RHIC II). Cooling gold ion beams at 100 GeV/nucleon requires an electron beam of approximately 54 MeV and a high average current in the range of 50-200 mA. All existing e-Coolers are based on low energy DC accelerators. The only viable option to generate high current, high energy, low emittance CW electron beam is through a superconducting energy-recovery linac (SC-ERL). In this option, an electron beam from a superconducting injector gun is accelerated using a high gradient (˜ 20 MV/m) superconducting RF (SRF) cavity. The electrons are returned back to the cavity with a 180° phase shift to recover the energy back into the cavity before being dumped. A design and development of a half-cell electron gun and a five-cell SRF linac cavity are presented. Several RF and beam dynamics issues ultimately resulting in an optimum cavity design are discussed in detail.

Linear Accelerator (LINAC)

MedlinePlus

... equipment? How is safety ensured? What is this equipment used for? A linear accelerator (LINAC) is the ... Therapy (SBRT) . top of page How does the equipment work? The linear accelerator uses microwave technology (similar ...

Neural processing of gravity information

NASA Technical Reports Server (NTRS)

Schor, Robert H.

1992-01-01

The goal of this project was to use the linear acceleration capabilities of the NASA Vestibular Research Facility (VRF) at Ames Research Center to directly examine encoding of linear accelerations in the vestibular system of the cat. Most previous studies, including my own, have utilized tilt stimuli, which at very low frequencies (e.g., 'static tilt') can be considered a reasonably pure linear acceleration (e.g., 'down'); however, higher frequencies of tilt, necessary for understanding the dynamic processing of linear acceleration information, necessarily involves rotations which can stimulate the semicircular canals. The VRF, particularly the Long Linear Sled, has promise to provide controlled pure linear accelerations at a variety of stimulus frequencies, with no confounding angular motion.

Satellite Formation Control Using Atmospheric Drag

DTIC Science & Technology

2007-03-01

of the formation. The linearized Clohessy - Wiltshire equations of motion are used to describe the motion of the two-satellite formation about an empty...control methods were applied to both the linear and nonlinear forms of the Clohessy - Wiltshire equations, and the performance of each control method was...r0δθ̈ = −2nδṙ + fθ (2.16) δz̈ = −n2δz + fz (2.17) These three equations are commonly known as Hill’s equations or the Clohessy - Wiltshire (CW

Department of Defense Joint Chemical and Biological Defense Program 2009 Annual Report to Congress

DTIC Science & Technology

2009-03-27

completion at the ECBC on the Edgewood Area of Aberdeen Proving Ground (APG), MD. The SRF is a collaborative effort, funded by the DoD, DHS, and...Accelerated Manufacture of Pharmaceuticals APB Acquisition Program Baseline APG Aberdeen Proving Ground ARC Annual Report to Congress ASC Active...Critical Reagents Program CUGV Chemical, Biological, Radiological, and Nuclear Unmanned Ground Vehicle CW Chemical Weapons CWA Chemical Warfare Agent CWC

Superconducting RF, the History, Challenges and Promise

ScienceCinema

Padamsee, Hasan

2018-01-01

After a short survey of on-going accelerator applications, I will discuss future applications prospects for this enabling technology, both near term and long term. A selection of technology highlights will serve as an introduction to outstanding issues for all types of applications, from pulsed high gradient to CW medium gradient. Finally I will touch upon the limits of niobium and the prospects of new materials. The talk will be targeted at a general audience.

Linear lesions in heart tissue using diffused laser radiation

NASA Astrophysics Data System (ADS)

Fried, Nathaniel M.; Lardo, Albert C.; Berger, Ronald D.; Calkins, Hugh; Halperin, Henry R.

2000-05-01

Transmural, continuous, and linear lesions may be necessary for successful catheter ablation of cardiac arrythmias such as atrial fibrillation. Laser ablation was studied as an alternative to radiofrequency ablation, which is noted to produce superficial and discontinuous lesions as well as tissue charring and vaporization. Samples of canine myocardium were placed in a saline bath and irradiated with an 1.06- micrometer Nd:YAG laser operated in either pulsed or continuous mode. For pulsed mode, the laser pulse duration was 10 s with 10 s cooling between pulses. Laser radiation was delivered radially through diffusing optical fiber tips oriented parallel to the endocardial surface. In CW mode, transmural (6-mm-deep), linear (16-mm-long), and continuous lesions were produced using a laser power of 30 W and an irradiation time of 180 s. Peak tissue temperatures measured 51 plus or minus 1 degree Celsius at the endocardial surface, 61 plus or minus 6 degrees Celsius in the mid-myocardium, and 55 plus or minus 6 degree Celsius at the epicardial surface. There was no evidence of tissue charring or vaporization. Pulsed laser irradiation produced comparable lesion depths to CW irradiation with more uniform heating of the subsurface myocardium, but at the expense of longer operation times. Further in vivo study of laser ablation is warranted for possible clinical applications.

Component resolved bleaching study in natural calcium fluoride using CW-OSL, LM-OSL and residual TL glow curves after bleaching.

PubMed

Angeli, Vasiliki; Polymeris, George S; Sfampa, Ioanna K; Tsirliganis, Nestor C; Kitis, George

2017-04-01

Natural calcium fluoride has been commonly used as thermoluminescence (TL) dosimeter due to its high luminescence intensity. The aim of this work includes attempting a correlation between specific TL glow curves after bleaching and components of linearly modulated optically stimulated luminescence (LM-OSL) as well as continuous wave OSL (CW-OSL). A component resolved analysis was applied to both integrated intensity of the RTL glow curves and all OSL decay curves, by using a Computerized Glow-Curve De-convolution (CGCD) procedure. All CW-OSL and LM-OSL components are correlated to the decay components of the integrated RTL signal, apart from two RTL components which cannot be directly correlated with either LM-OSL or CW-OSL component. The unique, stringent criterion for this correlation deals with the value of the decay constant λ of each bleaching component. There is only one, unique bleaching component present in all three luminescence entities which were the subject of the present study, indicating that each TL trap yields at least three different bleaching components; different TL traps can indicate bleaching components with similar values. According to the data of the present work each RTL bleaching component receives electrons from at least two peaks. The results of the present study strongly suggest that the traps that contribute to TL and OSL are the same. Copyright © 2017 Elsevier Ltd. All rights reserved.

Voltage regulation in linear induction accelerators

DOEpatents

Parsons, William M.

1992-01-01

Improvement in voltage regulation in a Linear Induction Accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance.

Is Africa a 'Graveyard' for Linear Accelerators?

PubMed

Reichenvater, H; Matias, L Dos S

2016-12-01

Linear accelerator downtimes are common and problematic in many African countries and may jeopardise the outcome of affected radiation treatments. The predicted increase in cancer incidence and prevalence on the African continent will require, inter alia, improved response with regard to a reduction in linear accelerator downtimes. Here we discuss the problems associated with the maintenance and repair of linear accelerators and propose alternative solutions relevant for local conditions in African countries. The paper is based on about four decades of experience in capacity building, installing, commissioning, calibrating, servicing and repairing linear accelerators in Africa, where about 40% of the low and middle income countries in the world are geographically located. Linear accelerators can successfully be operated, maintained and repaired in African countries provided proper maintenance and repair plans are put in place and executed. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Reproductive Biology of the Blue Swimming Crab Portunus pelagicus (Brachyura: Portunidae) in East Lampung Waters, Indonesia: Fecundity and Reproductive Potential

PubMed Central

Zairion; Wardiatno, Yusli; Boer, Mennofatria; Fahrudin, Achmad

2015-01-01

The blue swimming crab Portunus pelagicus is an important catch species for many coastal villages along the Java Sea coastline, but little is known regarding its reproductive biology or stock status. We examined the batch fecundity of female crabs that were collected monthly at landing sites from June 2011 to May 2012, calculated the relationships with body size, egg mass and month of the year, and determined the size at which females became potentially reproductive in the population inhabiting East Lampung waters (western Java Sea). Fecundity values ranged from 229,468 to 2,236,355 (mean = 926,638±30,975 [±SE]). The fecundity was positively and linearly correlated with carapace width (CW), but the relationships with body weight and egg mass were best described by logarithmic regression. A peaked, temporally cyclical pattern in fecundity was observed, with a peak period that was significantly different (F = 226.36; df = 22, p<0.05) from March to May 2012. Reproductive females were within the 111.0–155.9 mm CW size range; significantly higher reproductive potentials (F = 14.59; df = 30, p<0.05) were found in females within the 126.0–130.9 mm CW size group. The current minimum legal size (MLS = 100 mm CW) is not an appropriate limit reference point, and a precautionary approach is needed for a sustainable harvesting strategy. Resetting the MLS to 115 mm CW would potentially provide adequate protection for spawning females and increase total egg production, thereby maintaining population productivity and enhancing resilience in the face of current fishing pressures. PMID:26019748

Present developments and status of electron sources for high power gyrotron tubes and free electron masers

NASA Astrophysics Data System (ADS)

Thumm, M.

1997-02-01

Gyrotron oscillators are mainly used as high power mm-wave sources for start-up, electron cyclotron heating (ECH) and diagnostics of magnetically confined plasmas for controlled thermonuclear fusion research. 140 GHz (110 GHz) gyrotrons with output power Pout = 0.55 MW (0.93 MW), pulse length τ = 3.0 s (2.0 s) and efficiency η = 40% (38%) are commercially available. Total efficiencies around 50% have been achieved using single-stage depressed collectors. Diagnostic gyrotrons deliver Pout = 40 kW with τ = 40 μs at frequencies up to 650 GHz ( η≥4%). Recently, gyrotron oscillators have also been successfully used in materials processing, for example sintering of high performance, structural and functional ceramics. Such technological applications require gyrotrons with f≥24 GHz, Pout = 10-100 kW, CW, η≥30%. This paper reports on recent achievements in the development of very high power mm-wave gyrotron oscillators for long pulse or CW operation. In addition a short overview of the present development status of gyrotrons for technological applications, gyroklystron amplifiers, gyro-TWT amplifiers, cyclotron autoresonance masers (CARMs) and free electron masers (FEMs) is given. The most impressive FEM output parameters are: Pout = 2GW, τ = 20 ns, η = 13% at 140 GHz (LLNL) and Pout = 15 kW, τ = 20 μs, η = 5% in the range from 120 to 900 GHz (UCSB). In gyro-devices, magnetron injection guns (MIGs) operating in the temperature limited current regime have thus far been used most successfully. Diode guns as well as triode guns with a modulating anode are employed. Tests of a MIG operated under space-charge limited conditions have been not very successful. Electrostatic CW FEMs are driven by thermionic Pierce guns whereas pulsed high power devices employ many types of accelerators as drivers for example pulse-line accelerators, microtrons and induction or rf linacs, using field and photo emission cathodes.

Beam dynamics simulation of a double pass proton linear accelerator

DOE PAGES

Hwang, Kilean; Qiang, Ji

2017-04-03

A recirculating superconducting linear accelerator with the advantage of both straight and circular accelerator has been demonstrated with relativistic electron beams. The acceleration concept of a recirculating proton beam was recently proposed and is currently under study. In order to further support the concept, the beam dynamics study on a recirculating proton linear accelerator has to be carried out. In this paper, we study the feasibility of a two-pass recirculating proton linear accelerator through the direct numerical beam dynamics design optimization and the start-to-end simulation. This study shows that the two-pass simultaneous focusing without particle losses is attainable including fullymore » 3D space-charge effects through the entire accelerator system.« less

The Role of Linear Acceleration in Visual-Vestibular Interactions and Implications in Aircraft Operations

NASA Technical Reports Server (NTRS)

Correia, Manning J.; Luke, Brian L.; McGrath, Braden J.; Clark, John B.; Rupert, Angus H.

1996-01-01

While considerable attention has been given to visual-vestibular interaction (VVI) during angular motion of the head as might occur during an aircraft spin, much less attention has been given to VVI during linear motion of the head. Such interaction might occur, for example, while viewing a stationary or moving display during vertical take-off and landing operations Research into linear VVI, particularly during prolonged periods of linear acceleration, has been hampered by the unavailability of a programmable translator capable of large excursions We collaborated with Otis Elevator Co. and used their research tower and elevator, whose motion could be digitally programmed, to vertically translate human subjects over a distance of 92.3 meters with a peak linear acceleration of 2 meters/sec(exp 2) During pulsatile or sinusoidal translation, the subjects viewed moving stripes (optokinetic stimulus) or a fixed point source (light emitting diode, led, display), respectively and it was generally found that. The direction of linear acceleration relative to the cardinal head axes and the direction of the slow component of optokinetic nystagmus (OKN) determined the extent of VVI during concomitant stripe motion and linear acceleration. Acceleration along the z head axis (A(sub z)) produced the largest VVI, particularly when the slow component of OKN was in the same direction as eye movements produced by the linear acceleration and Eye movements produced by linear acceleration are suppressed by viewing a fixed target at frequencies below 10 Hz But, above this frequency the suppression produced by VVI is removed. Finally, as demonstrated in non-human primates, vergence of the eyes appears to modulate the vertical eye movement response to linear acceleration in humans.

Voltage regulation in linear induction accelerators

DOEpatents

Parsons, W.M.

1992-12-29

Improvement in voltage regulation in a linear induction accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core is disclosed. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance. 4 figs.

A High Peak Current Source for the CEBAF Injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yunn, Byung; Sinclair, Charles; Krafft, Geoffrey

1992-07-01

The CEBAF accelerator can drive high power IR and UV FELs, if a high peak current source is added to the existing front end. We present a design for a high peak current injector which is compatible with simultaneous operation of the accelerator for cw nulear physics (NP) beam. The high peak current injector provides 60 A peak current in 2 psec long bunches carrying 120 pC charge at 7.485 MHz. At 10 MeV that beam is combined with 5 MeV NP beam (0.13pC, 2 psec long bunches at 1497 MHz) in an energy combination chicane for simultaneous acceleration inmore » the injector linac. The modifications to the low-energy NP transport are described. Results of optical and beam dynamics calculations for both high peak current and NP beams in combined operation are presented.« less

THE BARYON CYCLE AT HIGH REDSHIFTS: EFFECTS OF GALACTIC WINDS ON GALAXY EVOLUTION IN OVERDENSE AND AVERAGE REGIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sadoun, Raphael; Shlosman, Isaac; Choi, Jun-Hwan

2016-10-01

We employ high-resolution cosmological zoom-in simulations focusing on a high-sigma peak and an average cosmological field at z ∼ 6–12 in order to investigate the influence of environment and baryonic feedback on galaxy evolution in the reionization epoch. Strong feedback, e.g., galactic winds, caused by elevated star formation rates (SFRs) is expected to play an important role in this evolution. We compare different outflow prescriptions: (i) constant wind velocity (CW), (ii) variable wind scaling with galaxy properties (VW), and (iii) no outflows (NW). The overdensity leads to accelerated evolution of dark matter and baryonic structures, absent from the “normal” region,more » and to shallow galaxy stellar mass functions at the low-mass end. Although CW shows little dependence on the environment, the more physically motivated VW model does exhibit this effect. In addition, VW can reproduce the observed specific SFR (sSFR) and the sSFR–stellar mass relation, which CW and NW fail to satisfy simultaneously. Winds also differ substantially in affecting the state of the intergalactic medium (IGM). The difference lies in the volume-filling factor of hot, high-metallicity gas, which is near unity for CW, while such gas remains confined in massive filaments for VW, and locked up in galaxies for NW. Such gas is nearly absent from the normal region. Although all wind models suffer from deficiencies, the VW model seems to be promising in correlating the outflow properties with those of host galaxies. Further constraints on the state of the IGM at high z are needed to separate different wind models.« less

The Baryon Cycle at High Redshifts: Effects of Galactic Winds on Galaxy Evolution in Overdense and Average Regions

NASA Astrophysics Data System (ADS)

Sadoun, Raphael; Shlosman, Isaac; Choi, Jun-Hwan; Romano-Díaz, Emilio

2016-10-01

We employ high-resolution cosmological zoom-in simulations focusing on a high-sigma peak and an average cosmological field at z ˜ 6-12 in order to investigate the influence of environment and baryonic feedback on galaxy evolution in the reionization epoch. Strong feedback, e.g., galactic winds, caused by elevated star formation rates (SFRs) is expected to play an important role in this evolution. We compare different outflow prescriptions: (I) constant wind velocity (CW), (II) variable wind scaling with galaxy properties (VW), and (III) no outflows (NW). The overdensity leads to accelerated evolution of dark matter and baryonic structures, absent from the “normal” region, and to shallow galaxy stellar mass functions at the low-mass end. Although CW shows little dependence on the environment, the more physically motivated VW model does exhibit this effect. In addition, VW can reproduce the observed specific SFR (sSFR) and the sSFR-stellar mass relation, which CW and NW fail to satisfy simultaneously. Winds also differ substantially in affecting the state of the intergalactic medium (IGM). The difference lies in the volume-filling factor of hot, high-metallicity gas, which is near unity for CW, while such gas remains confined in massive filaments for VW, and locked up in galaxies for NW. Such gas is nearly absent from the normal region. Although all wind models suffer from deficiencies, the VW model seems to be promising in correlating the outflow properties with those of host galaxies. Further constraints on the state of the IGM at high z are needed to separate different wind models.

The Spallation Neutron Source accelerator system design

NASA Astrophysics Data System (ADS)

Henderson, S.; Abraham, W.; Aleksandrov, A.; Allen, C.; Alonso, J.; Anderson, D.; Arenius, D.; Arthur, T.; Assadi, S.; Ayers, J.; Bach, P.; Badea, V.; Battle, R.; Beebe-Wang, J.; Bergmann, B.; Bernardin, J.; Bhatia, T.; Billen, J.; Birke, T.; Bjorklund, E.; Blaskiewicz, M.; Blind, B.; Blokland, W.; Bookwalter, V.; Borovina, D.; Bowling, S.; Bradley, J.; Brantley, C.; Brennan, J.; Brodowski, J.; Brown, S.; Brown, R.; Bruce, D.; Bultman, N.; Cameron, P.; Campisi, I.; Casagrande, F.; Catalan-Lasheras, N.; Champion, M.; Champion, M.; Chen, Z.; Cheng, D.; Cho, Y.; Christensen, K.; Chu, C.; Cleaves, J.; Connolly, R.; Cote, T.; Cousineau, S.; Crandall, K.; Creel, J.; Crofford, M.; Cull, P.; Cutler, R.; Dabney, R.; Dalesio, L.; Daly, E.; Damm, R.; Danilov, V.; Davino, D.; Davis, K.; Dawson, C.; Day, L.; Deibele, C.; Delayen, J.; DeLong, J.; Demello, A.; DeVan, W.; Digennaro, R.; Dixon, K.; Dodson, G.; Doleans, M.; Doolittle, L.; Doss, J.; Drury, M.; Elliot, T.; Ellis, S.; Error, J.; Fazekas, J.; Fedotov, A.; Feng, P.; Fischer, J.; Fox, W.; Fuja, R.; Funk, W.; Galambos, J.; Ganni, V.; Garnett, R.; Geng, X.; Gentzlinger, R.; Giannella, M.; Gibson, P.; Gillis, R.; Gioia, J.; Gordon, J.; Gough, R.; Greer, J.; Gregory, W.; Gribble, R.; Grice, W.; Gurd, D.; Gurd, P.; Guthrie, A.; Hahn, H.; Hardek, T.; Hardekopf, R.; Harrison, J.; Hatfield, D.; He, P.; Hechler, M.; Heistermann, F.; Helus, S.; Hiatt, T.; Hicks, S.; Hill, J.; Hill, J.; Hoff, L.; Hoff, M.; Hogan, J.; Holding, M.; Holik, P.; Holmes, J.; Holtkamp, N.; Hovater, C.; Howell, M.; Hseuh, H.; Huhn, A.; Hunter, T.; Ilg, T.; Jackson, J.; Jain, A.; Jason, A.; Jeon, D.; Johnson, G.; Jones, A.; Joseph, S.; Justice, A.; Kang, Y.; Kasemir, K.; Keller, R.; Kersevan, R.; Kerstiens, D.; Kesselman, M.; Kim, S.; Kneisel, P.; Kravchuk, L.; Kuneli, T.; Kurennoy, S.; Kustom, R.; Kwon, S.; Ladd, P.; Lambiase, R.; Lee, Y. Y.; Leitner, M.; Leung, K.-N.; Lewis, S.; Liaw, C.; Lionberger, C.; Lo, C. C.; Long, C.; Ludewig, H.; Ludvig, J.; Luft, P.; Lynch, M.; Ma, H.; MacGill, R.; Macha, K.; Madre, B.; Mahler, G.; Mahoney, K.; Maines, J.; Mammosser, J.; Mann, T.; Marneris, I.; Marroquin, P.; Martineau, R.; Matsumoto, K.; McCarthy, M.; McChesney, C.; McGahern, W.; McGehee, P.; Meng, W.; Merz, B.; Meyer, R.; Meyer, R.; Miller, B.; Mitchell, R.; Mize, J.; Monroy, M.; Munro, J.; Murdoch, G.; Musson, J.; Nath, S.; Nelson, R.; Nelson, R.; O`Hara, J.; Olsen, D.; Oren, W.; Oshatz, D.; Owens, T.; Pai, C.; Papaphilippou, I.; Patterson, N.; Patterson, J.; Pearson, C.; Pelaia, T.; Pieck, M.; Piller, C.; Plawski, T.; Plum, M.; Pogge, J.; Power, J.; Powers, T.; Preble, J.; Prokop, M.; Pruyn, J.; Purcell, D.; Rank, J.; Raparia, D.; Ratti, A.; Reass, W.; Reece, K.; Rees, D.; Regan, A.; Regis, M.; Reijonen, J.; Rej, D.; Richards, D.; Richied, D.; Rode, C.; Rodriguez, W.; Rodriguez, M.; Rohlev, A.; Rose, C.; Roseberry, T.; Rowton, L.; Roybal, W.; Rust, K.; Salazer, G.; Sandberg, J.; Saunders, J.; Schenkel, T.; Schneider, W.; Schrage, D.; Schubert, J.; Severino, F.; Shafer, R.; Shea, T.; Shishlo, A.; Shoaee, H.; Sibley, C.; Sims, J.; Smee, S.; Smith, J.; Smith, K.; Spitz, R.; Staples, J.; Stein, P.; Stettler, M.; Stirbet, M.; Stockli, M.; Stone, W.; Stout, D.; Stovall, J.; Strelo, W.; Strong, H.; Sundelin, R.; Syversrud, D.; Szajbler, M.; Takeda, H.; Tallerico, P.; Tang, J.; Tanke, E.; Tepikian, S.; Thomae, R.; Thompson, D.; Thomson, D.; Thuot, M.; Treml, C.; Tsoupas, N.; Tuozzolo, J.; Tuzel, W.; Vassioutchenko, A.; Virostek, S.; Wallig, J.; Wanderer, P.; Wang, Y.; Wang, J. G.; Wangler, T.; Warren, D.; Wei, J.; Weiss, D.; Welton, R.; Weng, J.; Weng, W.-T.; Wezensky, M.; White, M.; Whitlatch, T.; Williams, D.; Williams, E.; Wilson, K.; Wiseman, M.; Wood, R.; Wright, P.; Wu, A.; Ybarrolaza, N.; Young, K.; Young, L.; Yourd, R.; Zachoszcz, A.; Zaltsman, A.; Zhang, S.; Zhang, W.; Zhang, Y.; Zhukov, A.

2014-11-01

The Spallation Neutron Source (SNS) was designed and constructed by a collaboration of six U.S. Department of Energy national laboratories. The SNS accelerator system consists of a 1 GeV linear accelerator and an accumulator ring providing 1.4 MW of proton beam power in microsecond-long beam pulses to a liquid mercury target for neutron production. The accelerator complex consists of a front-end negative hydrogen-ion injector system, an 87 MeV drift tube linear accelerator, a 186 MeV side-coupled linear accelerator, a 1 GeV superconducting linear accelerator, a 248-m circumference accumulator ring and associated beam transport lines. The accelerator complex is supported by ~100 high-power RF power systems, a 2 K cryogenic plant, ~400 DC and pulsed power supply systems, ~400 beam diagnostic devices and a distributed control system handling ~100,000 I/O signals. The beam dynamics design of the SNS accelerator is presented, as is the engineering design of the major accelerator subsystems.

Drift tube suspension for high intensity linear accelerators

DOEpatents

Liska, D.J.; Schamaun, R.G.; Clark, D.C.; Potter, R.C.; Frank, J.A.

1980-03-11

The disclosure relates to a drift tube suspension for high intensity linear accelerators. The system comprises a series of box-sections girders independently adjustably mounted on a linear accelerator. A plurality of drift tube holding stems are individually adjustably mounted on each girder.

Design, construction and evaluation of a 12.2 GHz, 4.0 kW-CW high efficiency klystron amplifier. [for satellite-borne TV broadcast transmitters

NASA Technical Reports Server (NTRS)

Vishida, J. M.; Brodersen, L. K.

1974-01-01

An analytical and experimental program is described, for studying design techniques for optimizing the conversion efficiency of klystron amplifiers, and to utilize these techniques in the development and fabrication of an X-band 4 kW cw klystron, for use in satellite-borne television broadcast transmitters. The design is based on a technique for increasing the RF beam current by using the second harmonic space charge forces in the bunched beam. Experimental analysis was also made of a method to enhance circuit efficiency in the klystron cavities. The design incorporates a collector which is demountable from the tube to facilitate multistage depressed collector experiments employing an axisymmetric, electrostatic collector for linear beam microwave tubes.

Luminosity Limitations of Linear Colliders Based on Plasma Acceleration

DOE PAGES

Lebedev, Valeri; Burov, Alexey; Nagaitsev, Sergei

2016-01-01

Particle acceleration in plasma creates a possibility of exceptionally high accelerating gradients and appears as a very attractive option for future linear electron-positron and/or photon-photon colliders. These high accelerating gradients were already demonstrated in a number of experiments. Furthermore, a linear collider requires exceptionally high beam brightness which still needs to be demonstrated. In this article we discuss major phenomena which limit the beam brightness of accelerated beam and, consequently, the collider luminosity.

Neural Network Model Of The PXIE RFQ Cooling System and Resonant Frequency Response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edelen, Auralee; Biedron, Sandra; Bowring, Daniel

2016-06-01

As part of the PIP-II Injector Experiment (PXIE) accel-erator, a four-vane radio frequency quadrupole (RFQ) accelerates a 30-keV, 1-mA to 10-mA H' ion beam to 2.1 MeV. It is designed to operate at a frequency of 162.5 MHz with arbitrary duty factor, including continuous wave (CW) mode. The resonant frequency is controlled solely by a water-cooling system. We present an initial neural network model of the RFQ frequency response to changes in the cooling system and RF power conditions during pulsed operation. A neural network model will be used in a model predictive control scheme to regulate the resonant frequencymore » of the RFQ.« less

Molecular diversity of HLA-Cw alleles in the Maratha community of Mumbai, Maharashtra, western India.

PubMed

Shankarkumar, U; Ghosh, K; Mohanty, D

2005-08-01

Recent advances suggest a significant role for the HLA-C locus as a target of alloreactions after bone marrow transplantation. The biological importance of products of the HLA-C locus, both as transplant antigens and as ligands for natural killer (NK) cells, is well established. A total of 10 different serologically defined HLA-Cw antigen specificities (Cw1-Cw10) are encoded by the C locus; however, there are now 151 different alleles that can be identified by molecular methods. Serological definition of Cw alleles therefore includes 20-50% blanks, which cannot be detected by the available antisera. We used the molecular method of polymerase chain reaction (PCR)-based sequence-specific amplification and probe hybridization to define Cw alleles in 91 individuals from the Maratha community, and compared the data with data for 92 serologically typed Maratha individuals from India. We identified Cw*12, Cw*14, Cw*15, Cw*16 and Cw*18, along with the serologically identified Cw*01, Cw*02, Cw*03, Cw*04, Cw*06 and Cw*07 alleles. The HLA-Cw blank allele frequency in the Maratha was reduced from 0.5706 to 0.00. Furthermore, by using a molecular technique, it was possible to identify novel allele subtypes, such as Cw*0104, Cw*0203 and Cw*0707, and a high frequency of Cw* 1801 in the Maratha community compared with other Indian and world populations. Our results will have clinical implications in related and unrelated HLA-matched bone marrow transplantation in India.

Status of the Warm Front End of PIP-II Injector Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shemyakin, Alexander; Alvarez, Matthew; Andrews, Richard

The Proton Improvement Plan II (PIP-II) at Fermilab is a program of upgrades to the injection complex. At its core is the design and construction of a CW-compatible, pulsed H⁻ SRF linac. To validate the concept of the front-end of such machine, a test accelerator known as PIP-II Injector Test is under construction. It includes a 10 mA DC, 30 keV H⁻ ion source, a 2 m-long Low Energy Beam Transport (LEBT), a 2.1 MeV CW RFQ, followed by a Medium Energy Beam Transport (MEBT) that feeds the first of 2 cryomodules increasing the beam energy to about 25 MeV,more » and a High Energy Beam Transport section (HEBT) that takes the beam to a dump. The ion source, LEBT, RFQ, and initial version of the MEBT have been built, installed, and commissioned. This report presents the overall status of the warm front end.« less

Production of High Intracavity UV Power From a CW Laser Source

NASA Technical Reports Server (NTRS)

David, R. T.; Chyba, T. H.; Keppel, C. E.; Gaskell, D.; Ent, R.

1998-01-01

The goal of this research project is to create a prototype high power CW source of ultraviolet (UV) photons for photon-electron scattering at the Thomas Jefferson National Accelerator Facility (TJNAF), Hall B. The facility will use optical resonant cavities to produce a high photon flux. The technical approach will be to frequency-double the 514.5 mn light from an Argon-Ion Laser to create 0.1 to 1.0 watt in the UV. The produced UV power will be stored in a resonant cavity to generate an high intracavity UV power of 102 to 103 watts. The specific aim of this project is to first design and construct the low-Q doubling cavity and lock it to the Argon-Ion wavelength. Secondly, the existing 514.5 nm high-Q build-up cavity and its locking electronics will be modified to create high intracavity UV power. The entire system will then be characterized and evaluated for possible beam line use.

A 350 MHz, 200 kW CW, Multiple Beam Inductive Output Tube - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

R.Lawrece Ives; George Collins; David Marsden Michael Read

2012-11-28

This program developed a 200 kW CW, 350 MHz, multiple beam inductive output tube (MBIOT) for driving accelerator cavities. The MBIOT operates at 30 kV with a gain of 23 dB. The estimated efficiency is 70%. The device uses seven electron beams, each transmitting 1.4 A of current. The tube is approximately six feet long and weighs approximately 400 lbs. The prototype device will be evaluated as a potential RF source for the Advanced Photon Source at Argonne National Laboratory (ANL). Because of issues related to delivery of the electron guns, it was not possible to complete assembly and testmore » of the MBIOT during the Phase II program. The device is being completed with support from Calabazas Creek Research, Inc., Communications & Power Industries, LLC. and the Naval Surface Weapons Center (NSWC) in Dahlgren, VA. The MBIOT will be initially tested at NSWC before delivery to ANL. The testing at NSWC is scheduled for February 2013.« less

Operating Experience and Reliability Improvements on the 5 kW CW Klystron at Jefferson Lab

NASA Astrophysics Data System (ADS)

Nelson, R.; Holben, S.

1997-05-01

With substantial operating hours on the RF system, considerable information on reliability of the 5 kW CW klystrons has been obtained. High early failure rates led to examination of the operating conditions and failure modes. Internal ceramic contamination caused premature failure of gun potting material and ultimate tube demise through arcing or ceramic fracture. A planned course of repotting and reconditioning of approximately 300 klystrons, plus careful attention to operating conditions and periodic analysis of operational data, has substantially reduced the failure rate. It is anticipated that implementation of planned supplemental monitoring systems for the klystrons will allow most catastrophic failures to be avoided. By predicting end of life, tubes can be changed out before they fail, thus minimizing unplanned downtime. Initial tests have also been conducted on this same klystron operated at higher voltages with resultant higher output power. The outcome of these tests will provide information to be considered for future upgrades to the accelerator.

Saddle antenna radio frequency ion sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudnikov, V., E-mail: vadim@muonsinc.com; Johnson, R.; Murray, S.

Existing RF ion sources for accelerators have specific efficiencies for H{sup +} and H{sup −} ion generation ∼3–5 mA/cm{sup 2} kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) surface plasma source (SPS) described here was developed to improve H{sup −} ion production efficiency, reliability, and availability. In SA RF ion source, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm{sup 2} kW. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA withmore » RF power ∼1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with ∼4 kW RF. Continuous wave (CW) operation of the SA SPS has been tested on the test stand. The general design of the CW SA SPS is based on the pulsed version. Some modifications were made to improve the cooling and cesiation stability. CW operation with negative ion extraction was tested with RF power up to ∼1.2 kW in the plasma with production up to Ic = 7 mA. A stable long time generation of H{sup −} beam without degradation was demonstrated in RF discharge with AlN discharge chamber.« less

Tunable cw Single-Frequency Source for Injection Seeding 2-micrometer Lasers

DTIC Science & Technology

1990-06-01

Nd:glass Slab Asilomar, CA, January, 1989. Laser for X-ray Lithography ," presented at Lasers 11. R. L. Byer, "Solid State Lasers for Accelerator 89, New...Alumni Association (Stanford Club of M.K. Reed and R.L. Byer, "A Nd:glass Slab Connecticut), April, 1989. Laserfor X-ray Lithography ," to be...and R.L. Byer, "A Nd:Glass Slab asymmetric quantum wells," invited paper QWA1 Laser for Soft X-ray Lithography ", paper MB4, International Quantum

Neuromuscular Control of Rapid Linear Accelerations in Fish

DTIC Science & Technology

2016-06-22

2014 30-Apr-2015 Approved for Public Release; Distribution Unlimited Final Report: Neuromuscular Control of Rapid Linear Accelerations in Fish The...it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. Tufts University Research... Control of Rapid Linear Accelerations in Fish Report Title In this project, we measured muscle activity, body movements, and flow patterns during linear

Design of four-beam IH-RFQ linear accelerator

NASA Astrophysics Data System (ADS)

Ikeda, Shota; Murata, Aki; Hayashizaki, Noriyosu

2017-09-01

The multi-beam acceleration method is an acceleration technique for low-energy high-intensity heavy ion beams, which involves accelerating multiple beams to decrease space charge effects, and then integrating these beams by a beam funneling system. At the Tokyo Institute of Technology a two beam IH-RFQ linear accelerator was developed using a two beam laser ion source with direct plasma injection scheme. This system accelerated a carbon ion beam with a current of 108 mA (54 mA/channel × 2) from 5 up to 60 keV/u. In order to demonstrate that a four-beam IH-RFQ linear accelerator is suitable for high-intensity heavy ion beam acceleration, we have been developing a four-beam prototype. A four-beam IH-RFQ linear accelerator consists of sixteen RFQ electrodes (4 × 4 set) with stem electrodes installed alternately on the upper and lower ridge electrodes. As a part of this development, we have designed a four-beam IH-RFQ linear accelerator using three dimensional electromagnetic simulation software and beam tracking simulation software. From these simulation results, we have designed the stem electrodes, the center plate and the side shells by evaluating the RF properties such as the resonance frequency, the power loss and the electric strength distribution between the RFQ electrodes.

Environmental and biological monitoring of PAHs exposure in coke-oven workers at the Taranto plant compared to two groups from the general population of Apulia, Italy.

PubMed

Campo, Laura; Vimercati, L; Carrus, A; Bisceglia, Lucia; Pesatori, Angela Cecilia; Bertazzi, P A; Assennato, G; Fustinoni, Silvia

2012-01-01

Polycyclic aromatic hydrocarbons (PAHs) exposure in the coke industry poses a risk for workers' health as well as for subjects living in the plant vicinity. To assess PAHs exposure in coke-oven workers (CW) at the Taranto plant, Apulia, and in subjects from the general population living near (NC) and far away (FC) from the plant. Exposure was assessed by personal air sampling and urinary 1-hydroxypyrene (1-OHP) measured in 100 CW 18 NC and 15 FC. Median airborne benzo[a]pyrene (BaP) levels were 152, 1.5, and 3.6 ng/m3 in CW NC, and FC, respectively. In CW, median 1-OHP increased from 1.45 to 1.96 microg/g creatinine (crt) during the work shift (p > 0.05); in NC and FC, 1-OHP levels were 0.56 and 0.53 microg/g crt. No significant differences between NC and FC for both air and urinary indices were found. BaP exposure in CW exceeded the recently proposed German acceptable (70 ng/m3) and tolerable (700 ng/m3) risk-based limit values in 82 and 11% of subjects, respectively. In NC and FC, BaP exposure exceeded the European target value for ambient air (1 ng/m3) in 67 and 60% of subjects, respectively. Biomonitoring showed that 21% of CW had 1-OHP levels higher than the proposed biological limit value for the coke-oven industry (4.4 microg/g crt), while 93% of FC, and 88% of NC, had 1-OHP levels exceeding the Italian reference value (0.3 microg/g crt). Among non-smokers, a linear regression between 1-OHP and BaP (Pearson value r = 0.65, p < 0.05) allowed us to estimate levels of 1.2 and 1.9 microg/g crt for 1-OHP end-of-shift corresponding to acceptable and tolerable limit values. Although lower than in the past, PAHs exposure in the coke plant still poses a health risk for workers and the general population and requires further efforts to improve workplace conditions.

TU-H-BRA-06: Characterization of a Linear Accelerator Operating in a Compact MRIGuided Radiation Therapy System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, O; Mutic, S; Li, H

2016-06-15

Purpose: To describe the performance of a linear accelerator operating in a compact MRI-guided radiation therapy system. Methods: A commercial linear accelerator was placed in an MRI unit that is employed in a commercial MR-based image guided radiation therapy (IGRT) system. The linear accelerator components were placed within magnetic field-reducing hardware that provided magnetic fields of less than 40 G for the magnetron, gun driver, and port circulator, with 1 G for the linear accelerator. The system did not employ a flattening filter. The test linear accelerator was an industrial 4 MV model that was employed to test the abilitymore » to run an accelerator in the MR environment. An MR-compatible diode detector array was used to measure the beam profiles with the accelerator outside and inside the MR field and with the gradient coils on and off to examine if there was any effect on the delivered dose distribution. The beam profiles and time characteristics of the beam were measured. Results: The beam profiles exhibited characteristic unflattened Bremsstrahlung features with less than ±1.5% differences in the profile magnitude when the system was outside and inside the magnet and less than 1% differences with the gradient coils on and off. The central axis dose rate fluctuated by less than 1% over a 30 second period when outside and inside the MRI. Conclusion: A linaccompatible MR design has been shown to be effective in not perturbing the operation of a commercial linear accelerator. While the accelerator used in the tests was 4MV, there is nothing fundamentally different with the operation of a 6MV unit, implying that the design will enable operation of the proposed clinical unit. Research funding provided by ViewRay, Inc.« less

Luis Alvarez, the Hydrogen Bubble Chamber, Tritium, and Dinosaurs

Science.gov Websites

linear accelerator, patented three types of radar still used today, designed an instrument that for 15 is available in documents and on the Web. Documents: Berkeley Proton Linear Accelerator, DOE Technical Report Download Adobe PDF Reader , June 1985 History of Proton Linear Accelerators, DOE Technical

MeRHIC - staging approach to eRHIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ptitsyn,V.; Beebe-Wang, J.; Ben-Zvi, I.

Design of a medium energy electron-ion collider (MeRHIC) is under development at the Collider-Accelerator Department at BNL. The design envisions construction of a 4 GeV electron accelerator in a local area inside and near the RHIC tunnel. Electrons will be produced by a polarized electron source and accelerated in energy recovery linacs. Collisions of the electron beam with 100 GeV/u heavy ions or with 250 GeV polarized protons will be arranged in the existing IP2 interaction region of RHIC. The luminosity of electron-proton collisions at the 10{sup 32} cm{sup -2}s{sup -1} level will be achieved with 50 mA CW electronmore » current and presently available proton beam parameters. Efficient proton beam cooling at collision energy may bring the luminosity to 10{sup 33} cm{sup -2}s{sup -1}. An important feature of MeRHIC is that it serves as a first stage of eRHIC, a future electron-ion collider at BNL with both higher luminosity and energy reach. The majority of MeRHIC accelerator components will be used in eRHIC.« less

Design, construction and evaluation of a 12.045 GHz, 2.0 kW-cw permanent-magnet focused klystron amplifier

NASA Technical Reports Server (NTRS)

Nishida, J. M.

1975-01-01

An analytical and experimental program to demonstrate the technical feasibility of a lightweight, high-efficiency, 1-2 kW cw, permanent magnet focused klystron operating at 12.0 GHz was described. The design is based on use of a samarium-cobalt permanent magnet for focusing of the electron beam and choice of the most optimum parameters for maximum efficiency. A filter-loaded output circuit is used for the required bandwidth. The design incorporates a collector which is demountable from the tube to facilitate multistage depressed collector experiments, permitting replacement with a NASA-designed axisymmetric, electrostatic collector for linear beam microwave tubes. A further requirement is that the focusing field between the last interaction gap and the collector decay in a prescribed manner referred to as adiabatic expansion.

CW-OSL measurement protocols using optical fibre Al2O3:C dosemeters.

PubMed

Edmund, J M; Andersen, C E; Marckmann, C J; Aznar, M C; Akselrod, M S; Bøtter-Jensen, L

2006-01-01

A new system for in vivo dosimetry during radiotherapy has been introduced. Luminescence signals from a small crystal of carbon-doped aluminium oxide (Al2O3:C) are transmitted through an optical fibre cable to an instrument that contains optical filters, a photomultiplier tube and a green (532 nm) laser. The prime output is continuous wave optically stimulated luminescence (CW-OSL) used for the measurement of the integrated dose. We demonstrate a measurement protocol with high reproducibility and improved linearity, which is suitable for clinical dosimetry. A crystal-specific minimum pre-dose is necessary for signal stabilisation. Simple background subtraction only partially removes the residual signal present at long integration times. Instead, the measurement protocol separates the decay curve into three individual components and only the fast and medium components were used.

Dual-wavelength, continuous-wave Yb:YAG laser for high-resolution photothermal common-path interferometry.

PubMed

Zhuang, Fengjiang; Jungbluth, Bernd; Gronloh, Bastian; Hoffmann, Hans-Dieter; Zhang, Ge

2013-07-20

We present a continuous-wave (CW) intracavity frequency-doubled Yb:YAG laser providing 1030 and 515 nm output simultaneously. This laser system was designed for photothermal common-path interferometry to measure spatially resolved profiles of the linear absorption in dielectric media and coatings for visible or infrared light as well as of the nonlinear absorption for the combination of both. A Z-shape laser cavity was designed, providing a beam waist in which an LBO crystal was located for effective second-harmonic generation (SHG). Suitable frequency conversion parameters and cavity configurations were discussed to achieve the optimal performance of a diode-pumped CW SHG laser. A 12.4 W 1030 nm laser and 5.4 W 515 nm laser were developed simultaneously in our experiment.

Study of optically stimulated luminescence in LiSrAlF6:Eu2+

NASA Astrophysics Data System (ADS)

More, Y. K.; Nikam, M. S.; Wankhede, S. P.; Moharil, S. V.

2018-05-01

In this context the results on beta induced thermoluminescence and optically stimulated luminescence properties of LiSrAlF6:Eu2+ are reported. Phosphor shows good luminescence properties for both thermal and optical stimulation. The continuous wave optically stimulated luminescence (CW-OSL) signal as recorded using blue (470 nm) stimulation was found to be 37 % that of standard phosphor Lithium Magnesium Phosphate. The phosphor shows linear response of CW-OSL for various exposures ranging from 20 mGy to 10 Gy with minimum detectable dose approximately equal to 13 µGy. About 20% reduction in the TL signal of the phosphor after OSL readout was observed. About 50% fading of OSL signal was observed within three days of irradiation out of which about 35% OSL signal depleted within a day after irradiation.

Distribution of HLA class I alleles and haplotypes in Korean.

PubMed Central

Kim, T. G.; Han, H.; Lim, B. U.; Kim, W.; Kim, S. M.

1993-01-01

The antigen (phenotype), gene (allele) and haplotype frequencies of HLA class I were analysed in 4,622 Koreans. With allele frequencies of over 0.05, the most frequent HLA-A,-B and -C antigens were A2, A24, A33, A11, A26, A31; B62, B51, B44, B54, B61, B35, B58, B60; Cw3, Cw1, Cw4, Cw7. Of these A2, A24, Cw1 and Cw3 were present in very high frequencies, respectively (0.3211, 0.2200, 0.2204, and 0.3737). The most common haplotypes with frequencies larger than 0.02 were A2-Blank, A33-B44, A33-B58, A11-B62, A24-B51, A24-B54, A2-B27, B54-Cw1, B58-Cw3, B51-Blank, B61-Cw3, B62-Cw4, B35-Cw3, B44-Blank, B60-Cw3, B27-Cw1, A2-Cw3, A2-Cw1, A24-Cw1, A33-Cw3, A26-Cw3, and A11-Cw4. A significant negative linkage disequilibrium was found for the haplotypes of A2-B7, A2-B44, A2-B58, A24-B13, A24-B27, A33-B54 and A33-B62, of which frequencies were larger than 0.003. The B-C and A-C haplotypes which showed the significant negative linkage disequilibrium were B44-Cw1, B51-Cw1, B44-Cw3,B62-Blank, A2-Cw4, A2-Blank, A11-Cw3, A11-Blank and A33-Cw1 and had frequencies higher than 0.01. The findings presented here could be used per se to estimate the populational relationships or as the control data for HLA-disease investigation. Furthermore they could provide the scope for the definition of new antigens. PMID:8240747

Terahertz-driven linear electron acceleration

PubMed Central

Nanni, Emilio A.; Huang, Wenqian R.; Hong, Kyung-Han; Ravi, Koustuban; Fallahi, Arya; Moriena, Gustavo; Dwayne Miller, R. J.; Kärtner, Franz X.

2015-01-01

The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30–50 MeV m−1 gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional radio-frequency structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing requirements due to the short wavelength of operation. Here we demonstrate linear acceleration of electrons with keV energy gain using optically generated terahertz pulses. Terahertz-driven accelerating structures enable high-gradient electron/proton accelerators with simple accelerating structures, high repetition rates and significant charge per bunch. These ultra-compact terahertz accelerators with extremely short electron bunches hold great potential to have a transformative impact for free electron lasers, linear colliders, ultrafast electron diffraction, X-ray science and medical therapy with X-rays and electron beams. PMID:26439410

Terahertz-driven linear electron acceleration

DOE PAGES

Nanni, Emilio A.; Huang, Wenqian R.; Hong, Kyung-Han; ...

2015-10-06

The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30–50 MeVm -1 gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional radio-frequency structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing requirements due to the short wavelength of operation. Here we demonstrate linear acceleration of electrons with keV energy gain using optically generated terahertz pulses. Terahertz-driven accelerating structures enable high-gradient electron/protonmore » accelerators with simple accelerating structures, high repetition rates and significant charge per bunch. As a result, these ultra-compact terahertz accelerators with extremely short electron bunches hold great potential to have a transformative impact for free electron lasers, linear colliders, ultrafast electron diffraction, X-ray science and medical therapy with X-rays and electron beams.« less

High-efficiency acceleration in the laser wakefield by a linearly increasing plasma density

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, Kegong; Wu, Yuchi; Zhu, Bin

The acceleration length and the peak energy of the electron beam are limited by the dephasing effect in the laser wakefield acceleration with uniform plasma density. Based on 2D-3V particle in cell simulations, the effects of a linearly increasing plasma density on the electron acceleration are investigated broadly. Comparing with the uniform plasma density, because of the prolongation of the acceleration length and the gradually increasing accelerating field due to the increasing plasma density, the electron beam energy is twice higher in moderate nonlinear wakefield regime. Because of the lower plasma density, the linearly increasing plasma density can also avoidmore » the dark current caused by additional injection. At the optimal acceleration length, the electron energy can be increased from 350 MeV (uniform) to 760 MeV (linearly increasing) with the energy spread of 1.8%, the beam duration is 5 fs and the beam waist is 1.25 μm. This linearly increasing plasma density distribution can be achieved by a capillary with special gas-filled structure, and is much more suitable for experiment.« less

MO-F-16A-02: Simulation of a Medical Linear Accelerator for Teaching Purposes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlone, M; Lamey, M; Anderson, R

Purpose: Detailed functioning of linear accelerator physics is well known. Less well developed is the basic understanding of how the adjustment of the linear accelerator's electrical components affects the resulting radiation beam. Other than the text by Karzmark, there is very little literature devoted to the practical understanding of linear accelerator functionality targeted at the radiotherapy clinic level. The purpose of this work is to describe a simulation environment for medical linear accelerators with the purpose of teaching linear accelerator physics. Methods: Varian type lineacs were simulated. Klystron saturation and peak output were modelled analytically. The energy gain of anmore » electron beam was modelled using load line expressions. The bending magnet was assumed to be a perfect solenoid whose pass through energy varied linearly with solenoid current. The dose rate calculated at depth in water was assumed to be a simple function of the target's beam current. The flattening filter was modelled as an attenuator with conical shape, and the time-averaged dose rate at a depth in water was determined by calculating kerma. Results: Fifteen analytical models were combined into a single model called SIMAC. Performance was verified systematically by adjusting typical linac control parameters. Increasing klystron pulse voltage increased dose rate to a peak, which then decreased as the beam energy was further increased due to the fixed pass through energy of the bending magnet. Increasing accelerator beam current leads to a higher dose per pulse. However, the energy of the electron beam decreases due to beam loading and so the dose rate eventually maximizes and the decreases as beam current was further increased. Conclusion: SIMAC can realistically simulate the functionality of a linear accelerator. It is expected to have value as a teaching tool for both medical physicists and linear accelerator service personnel.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hwang, Kilean; Qiang, Ji

A recirculating superconducting linear accelerator with the advantage of both straight and circular accelerator has been demonstrated with relativistic electron beams. The acceleration concept of a recirculating proton beam was recently proposed and is currently under study. In order to further support the concept, the beam dynamics study on a recirculating proton linear accelerator has to be carried out. In this paper, we study the feasibility of a two-pass recirculating proton linear accelerator through the direct numerical beam dynamics design optimization and the start-to-end simulation. This study shows that the two-pass simultaneous focusing without particle losses is attainable including fullymore » 3D space-charge effects through the entire accelerator system.« less

A system for monitoring the radiation effects of a proton linear accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skorkin, V. M., E-mail: skorkin@inr.ru; Belyanski, K. L.; Skorkin, A. V.

2016-12-15

The system for real-time monitoring of radioactivity of a high-current proton linear accelerator detects secondary neutron emission from proton beam losses in transport channels and measures the activity of radionuclides in gas and aerosol emissions and the radiation background in the environment affected by a linear accelerator. The data provided by gamma, beta, and neutron detectors are transferred over a computer network to the central server. The system allows one to monitor proton beam losses, the activity of gas and aerosol emissions, and the radiation emission level of a linear accelerator in operation.

Isochronous (CW) Non-Scaling FFAGs: Design and Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnstone, C.; Berz, M.; Makino, K.

2010-11-04

The drive for higher beam power, high duty cycle, and reliable beams at reasonable cost has focused international attention and design effort on fixed field accelerators, notably Fixed-Field Alternating Gradient accelerators (FFAGs). High-intensity GeV proton drivers encounter duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons. A 10-20 MW proton driver is challenging, if even technically feasible, with conventional accelerators--with the possible exception of a SRF linac, which has a large associated cost and footprint. Recently, the concept of isochronous orbits has been explored and developed for nonscaling FFAGs using powerful new methodologiesmore » in FFAG accelerator design and simulation. The property of isochronous orbits enables the simplicity of fixed RF and, by tailoring a nonlinear radial field profile, the FFAG can remain isochronous beyond the energy reach of cyclotrons, well into the relativistic regime. With isochronous orbits, the machine proposed here has the high average current advantage and duty cycle of the cyclotron in combination with the strong focusing, smaller losses, and energy variability that are more typical of the synchrotron. This paper reports on these new advances in FFAG accelerator technology and presents advanced modeling tools for fixed-field accelerators unique to the code COSY INFINITY.« less

Sci—Fri PM: Topics — 05: Experience with linac simulation software in a teaching environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlone, Marco; Harnett, Nicole; Jaffray, David

Medical linear accelerator education is usually restricted to use of academic textbooks and supervised access to accelerators. To facilitate the learning process, simulation software was developed to reproduce the effect of medical linear accelerator beam adjustments on resulting clinical photon beams. The purpose of this report is to briefly describe the method of operation of the software as well as the initial experience with it in a teaching environment. To first and higher orders, all components of medical linear accelerators can be described by analytical solutions. When appropriate calibrations are applied, these analytical solutions can accurately simulate the performance ofmore » all linear accelerator sub-components. Grouped together, an overall medical linear accelerator model can be constructed. Fifteen expressions in total were coded using MATLAB v 7.14. The program was called SIMAC. The SIMAC program was used in an accelerator technology course offered at our institution; 14 delegates attended the course. The professional breakdown of the participants was: 5 physics residents, 3 accelerator technologists, 4 regulators and 1 physics associate. The course consisted of didactic lectures supported by labs using SIMAC. At the conclusion of the course, eight of thirteen delegates were able to successfully perform advanced beam adjustments after two days of theory and use of the linac simulator program. We suggest that this demonstrates good proficiency in understanding of the accelerator physics, which we hope will translate to a better ability to understand real world beam adjustments on a functioning medical linear accelerator.« less

Assessment of laser-induced acceleration effects in optical clearing of in vivo human skin by optical coherence tomography

NASA Astrophysics Data System (ADS)

Zhan, Zhigang; Wei, Huajiang; Jin, Ying

2015-02-01

Laser irradiation is considered to be a promising innovative technology which has been developed in an attempt to increase transdermal drug delivery. In this study, a near-infrared CW diode laser (785 nm) was applied to increase permeability of glycerol solutions in human skin in vivo and improve the optical clearing efficacy. Results show that for both 15%v/v and 30%v/v glycerol, the permeability coefficient increased significantly if the detected area of the skin tissue was treated with laser irradiation before optical clearing agents (OCAs) were applied. This study based on optical coherence tomography imaging technique and optical clearing effect finds laser irradiation a new approach for enhancing the penetration of OCAs and accelerating the rate of transdermal drug delivery.

Variable-energy drift-tube linear accelerator

DOEpatents

Swenson, Donald A.; Boyd, Jr., Thomas J.; Potter, James M.; Stovall, James E.

1984-01-01

A linear accelerator system includes a plurality of post-coupled drift-tubes wherein each post coupler is bistably positionable to either of two positions which result in different field distributions. With binary control over a plurality of post couplers, a significant accumlative effect in the resulting field distribution is achieved yielding a variable-energy drift-tube linear accelerator.

Variable-energy drift-tube linear accelerator

DOEpatents

Swenson, D.A.; Boyd, T.J. Jr.; Potter, J.M.; Stovall, J.E.

A linear accelerator system includes a plurality of post-coupled drift-tubes wherein each post coupler is bistably positionable to either of two positions which result in different field distributions. With binary control over a plurality of post couplers, a significant accumlative effect in the resulting field distribution is achieved yielding a variable-energy drift-tube linear accelerator.

Free electron lasers driven by linear induction accelerators: High power radiation sources

NASA Technical Reports Server (NTRS)

Orzechowski, T. J.

1989-01-01

The technology of Free Electron Lasers (FELs) and linear induction accelerators (LIAs) is addressed by outlining the following topics: fundamentals of FELs; basic concepts of linear induction accelerators; the Electron Laser Facility (a microwave FEL); PALADIN (an infrared FEL); magnetic switching; IMP; and future directions (relativistic klystrons). This presentation is represented by viewgraphs only.

Electron Source based on Superconducting RF

NASA Astrophysics Data System (ADS)

Xin, Tianmu

High-bunch-charge photoemission electron-sources operating in a Continuous Wave (CW) mode can provide high peak current as well as the high average current which are required for many advanced applications of accelerators facilities, for example, electron coolers for hadron beams, electron-ion colliders, and Free-Electron Lasers (FELs). Superconducting Radio Frequency (SRF) has many advantages over other electron-injector technologies, especially when it is working in CW mode as it offers higher repetition rate. An 112 MHz SRF electron photo-injector (gun) was developed at Brookhaven National Laboratory (BNL) to produce high-brightness and high-bunch-charge bunches for electron cooling experiments. The gun utilizes a Quarter-Wave Resonator (QWR) geometry for a compact structure and improved electron beam dynamics. The detailed RF design of the cavity, fundamental coupler and cathode stalk are presented in this work. A GPU accelerated code was written to improve the speed of simulation of multipacting, an important hurdle the SRF structure has to overcome in various locations. The injector utilizes high Quantum Efficiency (QE) multi-alkali photocathodes (K2CsSb) for generating electrons. The cathode fabrication system and procedure are also included in the thesis. Beam dynamic simulation of the injector was done with the code ASTRA. To find the optimized parameters of the cavities and beam optics, the author wrote a genetic algorithm Python script to search for the best solution in this high-dimensional parameter space. The gun was successfully commissioned and produced world record bunch charge and average current in an SRF photo-injector.

Accelerator Science: Circular vs. Linear

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

Computation of linear acceleration through an internal model in the macaque cerebellum

PubMed Central

Laurens, Jean; Meng, Hui; Angelaki, Dora E.

2013-01-01

A combination of theory and behavioral findings has supported a role for internal models in the resolution of sensory ambiguities and sensorimotor processing. Although the cerebellum has been proposed as a candidate for implementation of internal models, concrete evidence from neural responses is lacking. Here we exploit un-natural motion stimuli, which induce incorrect self-motion perception and eye movements, to explore the neural correlates of an internal model proposed to compensate for Einstein’s equivalence principle and generate neural estimates of linear acceleration and gravity. We show that caudal cerebellar vermis Purkinje cells and cerebellar nuclei neurons selective for actual linear acceleration also encode erroneous linear acceleration, as expected from the internal model hypothesis, even when no actual linear acceleration occurs. These findings provide strong evidence that the cerebellum might be involved in the implementation of internal models that mimic physical principles to interpret sensory signals, as previously hypothesized by theorists. PMID:24077562

Applications of High Intensity Proton Accelerators

NASA Astrophysics Data System (ADS)

Raja, Rajendran; Mishra, Shekhar

2010-06-01

Superconducting radiofrequency linac development at Fermilab / S. D. Holmes -- Rare muon decay experiments / Y. Kuno -- Rare kaon decays / D. Bryman -- Muon collider / R. B. Palmer -- Neutrino factories / S. Geer -- ADS and its potential / J.-P. Revol -- ADS history in the USA / R. L. Sheffield and E. J. Pitcher -- Accelerator driven transmutation of waste: high power accelerator for the European ADS demonstrator / J. L. Biarrotte and T. Junquera -- Myrrha, technology development for the realisation of ADS in EU: current status & prospects for realisation / R. Fernandez ... [et al.] -- High intensity proton beam production with cyclotrons / J. Grillenberger and M. Seidel -- FFAG for high intensity proton accelerator / Y. Mori -- Kaon yields for 2 to 8 GeV proton beams / K. K. Gudima, N. V. Mokhov and S. I. Striganov -- Pion yield studies for proton driver beams of 2-8 GeV kinetic energy for stopped muon and low-energy muon decay experiments / S. I. Striganov -- J-Parc accelerator status and future plans / H. Kobayashi -- Simulation and verification of DPA in materials / N. V. Mokhov, I. L. Rakhno and S. I. Striganov -- Performance and operational experience of the CNGS facility / E. Gschwendtner -- Particle physics enabled with super-conducting RF technology - summary of working group 1 / D. Jaffe and R. Tschirhart -- Proton beam requirements for a neutrino factory and muon collider / M. S. Zisman -- Proton bunching options / R. B. Palmer -- CW SRF H linac as a proton driver for muon colliders and neutrino factories / M. Popovic, C. M. Ankenbrandt and R. P. Johnson -- Rapid cycling synchrotron option for Project X / W. Chou -- Linac-based proton driver for a neutrino factory / R. Garoby ... [et al.] -- Pion production for neutrino factories and muon colliders / N. V. Mokhov ... [et al.] -- Proton bunch compression strategies / V. Lebedev -- Accelerator test facility for muon collider and neutrino factory R&D / V. Shiltsev -- The superconducting RF linac for muon collider and neutrino factory - summary of working group 2 / J. Galambos, R. Garoby and S. Geer -- Prospects for a very high power CW SRF linac / R. A. Rimmer -- Indian accelerator program for ADS applications / V. C. Sahni and P. Singh -- Ion accelerator activities at VECC (particularly, operating at low temperature) / R. K. Bhandari -- Chinese efforts in high intensity proton accelerators / S. Fu, J. Wang and S. Fang -- ADSR activity in the UK / R. J. Barlow -- ADS development in Japan / K. Kikuchi -- Project-X, SRF, and very large power stations / C. M. Ankenbrandt, R. P. Johnson and M. Popovic -- Power production and ADS / R. Raja -- Experimental neutron source facility based on accelerator driven system / Y. Gohar -- Transmutation mission / W. S. Yang -- Safety performance and issues / J. E. Cahalan -- Spallation target design for accelerator-driven systems / Y. Gohar -- Design considerations for accelerator transmutation of waste system / W. S. Yang -- Japan ADS program / T. Sasa -- Overview of members states' and IAEA activities in the field of Accelerator Driven Systems (ADS) / A. Stanculescu -- Linac for ADS applications - accelerator technologies / R. W. Garnett and R. L. Sheffield -- SRF linacs and accelerator driven sub-critical systems - summary working groups 3 & 4 / J. Delayen -- Production of Actinium-225 via high energy proton induced spallation of Thorium-232 / J. Harvey ... [et al.] -- Search for the electric dipole moment of Radium-225 / R. J. Holt, Z.-T. Lu and R. Mueller -- SRF linac and material science and medicine - summary of working group 5 / J. Nolen, E. Pitcher and H. Kirk.

Design of Linear Accelerator (LINAC) tanks for proton therapy via Particle Swarm Optimization (PSO) and Genetic Algorithm (GA) approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castellano, T.; De Palma, L.; Laneve, D.

2015-07-01

A homemade computer code for designing a Side- Coupled Linear Accelerator (SCL) is written. It integrates a simplified model of SCL tanks with the Particle Swarm Optimization (PSO) algorithm. The computer code main aim is to obtain useful guidelines for the design of Linear Accelerator (LINAC) resonant cavities. The design procedure, assisted via the aforesaid approach seems very promising, allowing future improvements towards the optimization of actual accelerating geometries. (authors)

Investigation of Ion Beam Production and Acceleration Using Linear Electron Beams and a Pulse Powered Plasma Focus.

DTIC Science & Technology

1984-03-01

POWERED PLASMA FOCUS Contract No. AFOSR-83-0145 PROGRESS REPORT For the Period April 1, 1983 through March 31, 1984 Submitted to Air Force Office of...AND ACCELERATION USING LINEAR ELECTRON BEAMS AND A PULSE POWERED PLASMA FOCUS Contract No. AFOSR-83-0145 PROGRESS REPORT For the Period April 1, 1983...Acceleration Using Linear Electron Beams and a Pulse Powered Plasma Focus " 01 €,G APRIL 1, 1983 THROUGH MRCH 31, 1984 A. Collective Acceleration and Related

The Rim Inertial Measuring System (RIMS). [to measure angular rate and linear acceleration of a moving vehicle

NASA Technical Reports Server (NTRS)

Groom, N. J.

1979-01-01

The rim inertial measuring system (RIMS) is introduced and an approach for extracting angular rate and linear acceleration information from a RIMS unit is presented and discussed. The RIMS consists of one or more small annular momentum control devices (AMCDs), mounted in a strapped down configuration, which are used to measure angular rates and linear accelerations of a moving vehicle. An AMCD consists of a spinning rim, a set of noncontacting magnetic bearings for supporting the rim, and a noncontacting electromagnetic spin motor. The approach for extracting angular rate and linear acceleration information is for a single spacecraft mounted RIMS unit.

MABE multibeam accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasti, D.E.; Ramirez, J.J.; Coleman, P.D.

1985-01-01

The Megamp Accelerator and Beam Experiment (MABE) was the technology development testbed for the multiple beam, linear induction accelerator approach for Hermes III, a new 20 MeV, 0.8 MA, 40 ns accelerator being developed at Sandia for gamma-ray simulation. Experimental studies of a high-current, single-beam accelerator (8 MeV, 80 kA), and a nine-beam injector (1.4 MeV, 25 kA/beam) have been completed, and experiments on a nine-beam linear induction accelerator are in progress. A two-beam linear induction accelerator is designed and will be built as a gamma-ray simulator to be used in parallel with Hermes III. The MABE pulsed power systemmore » and accelerator for the multiple beam experiments is described. Results from these experiments and the two-beam design are discussed. 11 refs., 6 figs.« less

Accelerator Science: Circular vs. Linear

ScienceCinema

Lincoln, Don

2018-06-12

Particle accelerator are scientific instruments that allow scientists to collide particles together at incredible energies to study the secrets of the universe. However, there are many manners in which particle accelerators can be constructed. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of circular and linear accelerators.

Experimental evidence of space charge driven resonances in high intensity linear accelerators

DOE PAGES

Jeon, Dong -O

2016-01-12

In the construction of high intensity accelerators, it is the utmost goal to minimize the beam loss by avoiding or minimizing contributions of various halo formation mechanisms. As a halo formation mechanism, space charge driven resonances are well known for circular accelerators. However, the recent finding showed that even in linear accelerators the space charge potential can excite the 4σ = 360° fourth order resonance [D. Jeon et al., Phys. Rev. ST Accel. Beams 12, 054204 (2009)]. This study increased the interests in space charge driven resonances of linear accelerators. Experimental studies of the space charge driven resonances of highmore » intensity linear accelerators are rare as opposed to the multitude of simulation studies. This paper presents an experimental evidence of the space charge driven 4σ ¼ 360° resonance and the 2σ x(y) – 2σ z = 0 resonance of a high intensity linear accelerator through beam profile measurements from multiple wire-scanners. Moreover, measured beam profiles agree well with the characteristics of the space charge driven 4σ = 360° resonance and the 2σ x(y) – 2σ z = 0 resonance that are predicted by the simulation.« less

Modeling of matter-wave solitons in a nonlinear inductor-capacitor network through a Gross-Pitaevskii equation with time-dependent linear potential

NASA Astrophysics Data System (ADS)

Kengne, E.; Lakhssassi, A.; Liu, W. M.

2017-08-01

A lossless nonlinear L C transmission network is considered. With the use of the reductive perturbation method in the semidiscrete limit, we show that the dynamics of matter-wave solitons in the network can be modeled by a one-dimensional Gross-Pitaevskii (GP) equation with a time-dependent linear potential in the presence of a chemical potential. An explicit expression for the growth rate of a purely growing modulational instability (MI) is presented and analyzed. We find that the potential parameter of the GP equation of the system does not affect the different regions of the MI. Neglecting the chemical potential in the GP equation, we derive exact analytical solutions which describe the propagation of both bright and dark solitary waves on continuous-wave (cw) backgrounds. Using the found exact analytical solutions of the GP equation, we investigate numerically the transmission of both bright and dark solitary voltage signals in the network. Our numerical studies show that the amplitude of a bright solitary voltage signal and the depth of a dark solitary voltage signal as well as their width, their motion, and their behavior depend on (i) the propagation frequencies, (ii) the potential parameter, and (iii) the amplitude of the cw background. The GP equation derived in this paper with a time-dependent linear potential opens up different ideas that may be of considerable theoretical interest for the management of matter-wave solitons in nonlinear L C transmission networks.

Intern Programs | Tours

Science.gov Websites

accelerated through the Linac (Linear Accelerator) to an energy of 400 MeV. The Linac consists of two main of linear accelerators at NML ! Meet at the South entrance to NML (New Muon Lab) Building. 1:00 PM 1

Perception of linear acceleration in weightlessness

NASA Technical Reports Server (NTRS)

Arrott, A. P.; Young, L. R.

1987-01-01

Eye movements and subjective detection of acceleration were measured on human experimental subjects during vestibular sled acceleration during the D1 Spacelab Mission. Methods and results are reported on the time to detection of small acceleration steps, the threshold for detection of linear acceleration, perceived motion path, and CLOAT. A consistently shorter time to detection of small acceleration steps is found. Subjective reports of perceived motion during sinusoidal oscillation in weightlessness were qualitatively similar to reports on earth.

Evaluating activation of the shielding walls of a treatment room using the Monte Carlo method

NASA Astrophysics Data System (ADS)

Lee, D.-Y.; Kim, J.-H.

2018-05-01

This study investigates the radiation activation process in a medical linear accelerator, which creates a photon beam with the energy acquired from accelerated electrons. The concrete shielding walls used in conjunction with a medical linear accelerator occupy the largest portion of facility decommissioning costs. Therefore, to evaluate the activation of the shielding wall, this study simulated the operation of a linear accelerator with high-energy photon beams (10, 15, and 20 MV). The results of the simulations showed that the high-energy photon beams produced a large number of neutrons in the areas around the linear accelerator head. Several radionuclides were identified, and their half-lives and radioactivity levels were calculated. Half-lives ranged from 2.62 hours to 3.68E+06 years, and the radioactivity levels of most of the radionuclides were found to satisfy their respective clearance requirements. These results indicate that photon beams of 15 MV or lower satisfy the clearance requirements for decommissioning a linear accelerator facility, whereas those of 20 MV or higher lie partially above the regulatory clearance levels.

Redesign of the End Group in the 3.9 GHz LCLS-II Cavity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lunin, Andrei; Gonin, Ivan; Khabiboulline, Timergali

Development and production of Linac Coherent Light Source II (LCLS-II) is underway. The central part of LCLS-II is a continuous wave superconducting RF (CW SCRF) electron linac. The 3.9 GHz third harmonic cavity similar to the XFEL design will be used in LCLS-II for linearizing the longitudinal beam profile*. The initial design of the 3.9 GHz cavity developed for XFEL project has a large, 40 mm, beam pipe aperture for better higher-order mode (HOM) damping. It is resulted in dipole HOMs with frequencies nearby the operating mode, which causes difficulties with HOM coupler notch filter tuning. The CW linac operationmore » requires an extra caution in the design of the HOM coupler in order to prevent its possible overheating. In this paper we present the modified 3.9 GHz cavity End Group for meeting the LCLS-II requirements« less

Augmentation of Antitumor T-Cell Responses by Increasing APC T-Cell C5a/C3a-C5aR/C3aR Interactions

DTIC Science & Technology

2013-03-01

the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes. The Journal of experimental medicine . 1984;160(5...cell immunity. The Journal of experimental medicine . 2005;201(10):1523-30. PubMed PMID: 15883171. 3. Vogel CW, Wilkie SD, Morgan AC. In vivo studies...with covalent conjugates of cobra venom factor and monoclonal antibodies to human tumors. Haematology and blood transfusion. 1985;29:514- 7. Epub

Linear Motor With Air Slide

NASA Technical Reports Server (NTRS)

Johnson, Bruce G.; Gerver, Michael J.; Hawkey, Timothy J.; Fenn, Ralph C.

1993-01-01

Improved linear actuator comprises air slide and linear electric motor. Unit exhibits low friction, low backlash, and more nearly even acceleration. Used in machinery in which positions, velocities, and accelerations must be carefully controlled and/or vibrations must be suppressed.

Intraoperative radiation therapy using mobile electron linear accelerators: report of AAPM Radiation Therapy Committee Task Group No. 72.

PubMed

Beddar, A Sam; Biggs, Peter J; Chang, Sha; Ezzell, Gary A; Faddegon, Bruce A; Hensley, Frank W; Mills, Michael D

2006-05-01

Intraoperative radiation therapy (IORT) has been customarily performed either in a shielded operating suite located in the operating room (OR) or in a shielded treatment room located within the Department of Radiation Oncology. In both cases, this cancer treatment modality uses stationary linear accelerators. With the development of new technology, mobile linear accelerators have recently become available for IORT. Mobility offers flexibility in treatment location and is leading to a renewed interest in IORT. These mobile accelerator units, which can be transported any day of use to almost any location within a hospital setting, are assembled in a nondedicated environment and used to deliver IORT. Numerous aspects of the design of these new units differ from that of conventional linear accelerators. The scope of this Task Group (TG-72) will focus on items that particularly apply to mobile IORT electron systems. More specifically, the charges to this Task Group are to (i) identify the key differences between stationary and mobile electron linear accelerators used for IORT, (ii) describe and recommend the implementation of an IORT program within the OR environment, (iii) present and discuss radiation protection issues and consequences of working within a nondedicated radiotherapy environment, (iv) describe and recommend the acceptance and machine commissioning of items that are specific to mobile electron linear accelerators, and (v) design and recommend an efficient quality assurance program for mobile systems.

A Comparison of Potential IM-CW Lidar Modulation Techniques for ASCENDS CO2 Column Measurements From Space

NASA Technical Reports Server (NTRS)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. Wallace; Obland, Michael D.; Ismail, Syed

2014-01-01

Global atmospheric carbon dioxide (CO2) measurements through the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) Decadal Survey recommended space mission are critical for improving our understanding of CO2 sources and sinks. IM-CW (Intensity Modulated Continuous Wave) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS science requirements. In previous laboratory and flight experiments we have successfully used linear swept frequency modulation to discriminate surface lidar returns from intermediate aerosol and cloud contamination. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate clouds, which is a requirement for the inversion of the CO2 column-mixing ratio from the instrument optical depth measurements, has been demonstrated with the linear swept frequency modulation technique. We are concurrently investigating advanced techniques to help improve the auto-correlation properties of the transmitted waveform implemented through physical hardware to make cloud rejection more robust in special restricted scenarios. Several different carrier based modulation techniques are compared including orthogonal linear swept, orthogonal non-linear swept, and Binary Phase Shift Keying (BPSK). Techniques are investigated that reduce or eliminate sidelobes. These techniques have excellent auto-correlation properties while possessing a finite bandwidth (by way of a new cyclic digital filter), which will reduce bias error in the presence of multiple scatterers. Our analyses show that the studied modulation techniques can increase the accuracy of CO2 column measurements from space. A comparison of various properties such as signal to noise ratio (SNR) and time-bandwidth product are discussed.

Continuous correction of differential path length factor in near-infrared spectroscopy

PubMed Central

Moore, Jason H.; Diamond, Solomon G.

2013-01-01

Abstract. In continuous-wave near-infrared spectroscopy (CW-NIRS), changes in the concentration of oxyhemoglobin and deoxyhemoglobin can be calculated by solving a set of linear equations from the modified Beer-Lambert Law. Cross-talk error in the calculated hemodynamics can arise from inaccurate knowledge of the wavelength-dependent differential path length factor (DPF). We apply the extended Kalman filter (EKF) with a dynamical systems model to calculate relative concentration changes in oxy- and deoxyhemoglobin while simultaneously estimating relative changes in DPF. Results from simulated and experimental CW-NIRS data are compared with results from a weighted least squares (WLSQ) method. The EKF method was found to effectively correct for artificially introduced errors in DPF and to reduce the cross-talk error in simulation. With experimental CW-NIRS data, the hemodynamic estimates from EKF differ significantly from the WLSQ (p<0.001). The cross-correlations among residuals at different wavelengths were found to be significantly reduced by the EKF method compared to WLSQ in three physiologically relevant spectral bands 0.04 to 0.15 Hz, 0.15 to 0.4 Hz and 0.4 to 2.0 Hz (p<0.001). This observed reduction in residual cross-correlation is consistent with reduced cross-talk error in the hemodynamic estimates from the proposed EKF method. PMID:23640027

Continuous correction of differential path length factor in near-infrared spectroscopy

NASA Astrophysics Data System (ADS)

Talukdar, Tanveer; Moore, Jason H.; Diamond, Solomon G.

2013-05-01

In continuous-wave near-infrared spectroscopy (CW-NIRS), changes in the concentration of oxyhemoglobin and deoxyhemoglobin can be calculated by solving a set of linear equations from the modified Beer-Lambert Law. Cross-talk error in the calculated hemodynamics can arise from inaccurate knowledge of the wavelength-dependent differential path length factor (DPF). We apply the extended Kalman filter (EKF) with a dynamical systems model to calculate relative concentration changes in oxy- and deoxyhemoglobin while simultaneously estimating relative changes in DPF. Results from simulated and experimental CW-NIRS data are compared with results from a weighted least squares (WLSQ) method. The EKF method was found to effectively correct for artificially introduced errors in DPF and to reduce the cross-talk error in simulation. With experimental CW-NIRS data, the hemodynamic estimates from EKF differ significantly from the WLSQ (p<0.001). The cross-correlations among residuals at different wavelengths were found to be significantly reduced by the EKF method compared to WLSQ in three physiologically relevant spectral bands 0.04 to 0.15 Hz, 0.15 to 0.4 Hz and 0.4 to 2.0 Hz (p<0.001). This observed reduction in residual cross-correlation is consistent with reduced cross-talk error in the hemodynamic estimates from the proposed EKF method.

ON THE PROBLEM OF PARTICLE GROUPINGS IN A TRAVELING WAVE LINEAR ACCELERATOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhileyko, G.I.

1957-01-01

A linear accelerator with traveling'' waves may be used for the production of especially short electron momenta, although in many cases the grouping capacity of the accelerator is not sufficient. Theoretically the case is derived in which grouping of the electrons takes place in the accelerator itself. (With 3 illustrations and 1 Slavic Reference). (TCO)

LINEAR ACCELERATOR

DOEpatents

Christofilos, N.C.; Polk, I.J.

1959-02-17

Improvements in linear particle accelerators are described. A drift tube system for a linear ion accelerator reduces gap capacity between adjacent drift tube ends. This is accomplished by reducing the ratio of the diameter of the drift tube to the diameter of the resonant cavity. Concentration of magnetic field intensity at the longitudinal midpoint of the external sunface of each drift tube is reduced by increasing the external drift tube diameter at the longitudinal center region.

A CW radiofrequency ion source for production of negative hydrogen ion beams for cyclotrons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalvas, T.; Tarvainen, O.; Komppula, J.

2015-04-08

A CW 13.56 MHz radiofrequency-driven ion source RADIS for production of H{sup −} and D{sup −} beams is under development for replacing the filament-driven ion source of the MCC30/15 cyclotron. The RF ion source has a 16-pole multicusp plasma chamber, an electromagnet-based magnetic filter and an external planar spiral RF antenna behind an AlN window. The extraction is a 5-electrode system with an adjustable puller electrode voltage for optimizing the beam formation, a water-cooled electron dump electrode and an accelerating einzel lens. At 2650 W of RF power, the source produces 1 mA of H{sup −} (2.6 mA/cm{sup 2}), which is the intensity neededmore » at injection for production of 200 µA H{sup +} with the filament-driven ion source. A simple pepperpot device has been developed for characterizing the beam emittance. Plans for improving the power efficiency with the use of a new permanent magnet front plate is discussed.« less

Resonant Frequency Control For the PIP-II Injector Test RFQ: Control Framework and Initial Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edelen, A. L.; Biedron, S. G.; Milton, S. V.

For the PIP-II Injector Test (PI-Test) at Fermilab, a four-vane radio frequency quadrupole (RFQ) is designed to accelerate a 30-keV, 1-mA to 10-mA, H- beam to 2.1 MeV under both pulsed and continuous wave (CW) RF operation. The available headroom of the RF amplifiers limits the maximum allowable detuning to 3 kHz, and the detuning is controlled entirely via thermal regulation. Fine control over the detuning, minimal manual intervention, and fast trip recovery is desired. In addition, having active control over both the walls and vanes provides a wider tuning range. For this, we intend to use model predictive controlmore » (MPC). To facilitate these objectives, we developed a dedicated control framework that handles higher-level system decisions as well as executes control calculations. It is written in Python in a modular fashion for easy adjustments, readability, and portability. Here we describe the framework and present the first control results for the PI-Test RFQ under pulsed and CW operation.« less

RF Simulation of the 187 MHz CW Photo-RF Gun Cavity at LBNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Tong-Ming

2008-12-01

A 187 MHz normal conducting Photo-RF gun cavity is designed for the next generation light sources. The cavity is capable of operating in CW mode. As high as 750 kV gap voltage can be achieved with a 20 MV/m acceleration gradient. The original cavity optimization is conducted using Superfish code (2D) by Staples. 104 vacuum pumping slots are added and evenly spaced over the cavity equator in order to achieve better than 10 -10-Tor of vacuum. Two loop couplers will be used to feed RF power into the cavity. 3D simulations are necessary to study effects from the vacuum pumpingmore » slots, couplers and possible multipactoring. The cavity geometry is optimized to minimize the power density and avoid multipactoring at operating field level. The vacuum slot dimensions are carefully chosen in consideration of both the vacuum conduction, local power density enhancement and the power attenuation at the getter pumps. This technical note gives a summary of 3D RF simulation results, multipactoring simulations (2D) and preliminary electromagnetic-thermal analysis using ANSYS code.« less

Minimizing Secular J2 Perturbation Effects on Satellite Formations

DTIC Science & Technology

2008-03-01

linear set of differential equations describing the relative motion was established by Hill as well as Clohessy and Wiltshire , with a slightly... Wiltshire (CW) equations, and Hill- Clohessy - Wiltshire (HCW) equations. In the simplest form these differential equations can be expressed as: 2 2 2 3 2...different orientation. Because these equations are much alike, the differential equations established are referred to as Hill’s equations, Clohessy

Optimal Control of a Circular Satellite Formation Subject to Gravitational Perturbations

DTIC Science & Technology

2007-03-01

fundamental reference in the study of the dynamics of close-proximity spacecraft is the paper by Clohessy and Wiltshire (5). In this work, the linear...dynamics for a satellite rendezvous problem are derived, which are now commonly known as either the Clohessy - Wiltshire (CW) equations or Hill’s...themselves to closed-form solutions, as did the Clohessy - Wiltshire development. When the nonlinear approach is undertaken, the numeric integration

Non-perturbative aspects of particle acceleration in non-linear electrodynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burton, David A.; Flood, Stephen P.; Wen, Haibao

2015-04-15

We undertake an investigation of particle acceleration in the context of non-linear electrodynamics. We deduce the maximum energy that an electron can gain in a non-linear density wave in a magnetised plasma, and we show that an electron can “surf” a sufficiently intense Born-Infeld electromagnetic plane wave and be strongly accelerated by the wave. The first result is valid for a large class of physically reasonable modifications of the linear Maxwell equations, whilst the second result exploits the special mathematical structure of Born-Infeld theory.

Detecting chaos in particle accelerators through the frequency map analysis method.

PubMed

Papaphilippou, Yannis

2014-06-01

The motion of beams in particle accelerators is dominated by a plethora of non-linear effects, which can enhance chaotic motion and limit their performance. The application of advanced non-linear dynamics methods for detecting and correcting these effects and thereby increasing the region of beam stability plays an essential role during the accelerator design phase but also their operation. After describing the nature of non-linear effects and their impact on performance parameters of different particle accelerator categories, the theory of non-linear particle motion is outlined. The recent developments on the methods employed for the analysis of chaotic beam motion are detailed. In particular, the ability of the frequency map analysis method to detect chaotic motion and guide the correction of non-linear effects is demonstrated in particle tracking simulations but also experimental data.

Wireless acceleration sensor of moving elements for condition monitoring of mechanisms

NASA Astrophysics Data System (ADS)

Sinitsin, Vladimir V.; Shestakov, Aleksandr L.

2017-09-01

Comprehensive analysis of the angular and linear accelerations of moving elements (shafts, gears) allows an increase in the quality of the condition monitoring of mechanisms. However, existing tools and methods measure either linear or angular acceleration with postprocessing. This paper suggests a new construction design of an angular acceleration sensor for moving elements. The sensor is mounted on a moving element and, among other things, the data transfer and electric power supply are carried out wirelessly. In addition, the authors introduce a method for processing the received information which makes it possible to divide the measured acceleration into the angular and linear components. The design has been validated by the results of laboratory tests of an experimental model of the sensor. The study has shown that this method provides a definite separation of the measured acceleration into linear and angular components, even in noise. This research contributes an advance in the range of methods and tools for condition monitoring of mechanisms.

1985 Particle Accelerator Conference: Accelerator Engineering and Technology, 11th, Vancouver, Canada, May 13-16, 1985, Proceedings

NASA Astrophysics Data System (ADS)

Strathdee, A.

1985-10-01

The topics discussed are related to high-energy accelerators and colliders, particle sources and electrostatic accelerators, controls, instrumentation and feedback, beam dynamics, low- and intermediate-energy circular accelerators and rings, RF and other acceleration systems, beam injection, extraction and transport, operations and safety, linear accelerators, applications of accelerators, radiation sources, superconducting supercolliders, new acceleration techniques, superconducting components, cryogenics, and vacuum. Accelerator and storage ring control systems are considered along with linear and nonlinear orbit theory, transverse and longitudinal instabilities and cures, beam cooling, injection and extraction orbit theory, high current dynamics, general beam dynamics, and medical and radioisotope applications. Attention is given to superconducting RF structures, magnet technology, superconducting magnets, and physics opportunities with relativistic heavy ion accelerators.

Linear laser diode arrays for improvement in optical disk recording for space stations

NASA Technical Reports Server (NTRS)

Alphonse, G. A.; Carlin, D. B.; Connolly, J. C.

1990-01-01

The design and fabrication of individually addressable laser diode arrays for high performance magneto-optic recording systems are presented. Ten diode arrays with 30 mW cW light output, linear light vs. current characteristics and single longitudinal mode spectrum were fabricated using channel substrate planar (CSP) structures. Preliminary results on the inverse CSP structure, whose fabrication is less critically dependent on device parameters than the CSP, are also presented. The impact of systems parameters and requirements, in particular, the effect of feedback on laser design is assessed, and techniques to reduce feedback or minimize its effect on systems performance, including mode-stabilized structures, are evaluated.

Design and Analysis of Megawatt Class Free Electron Laser Weapons

DTIC Science & Technology

2015-12-01

accelerating structure. The SRF linear accelerator stores RF fields within its niobium cavities. Superconductors require less average RF power than...is needed to cool the superconductor for the SRF linear accelerator. A current outstanding research topic is the RF frequency to use for the SRF

Superconducting six-axis accelerometer

NASA Technical Reports Server (NTRS)

Paik, H. J.

1990-01-01

A new superconducting accelerometer, capable of measuring both linear and angular accelerations, is under development at the University of Maryland. A single superconducting proof mass is magnetically levitated against gravity or any other proof force. Its relative positions and orientations with respect to the platform are monitored by six superconducting inductance bridges sharing a single amplifier, called the Superconducting Quantum Interference Device (SQUID). The six degrees of freedom, the three linear acceleration components and the three angular acceleration components, of the platform are measured simultaneously. In order to improve the linearity and the dynamic range of the instrument, the demodulated outputs of the SQUID are fed back to appropriate levitation coils so that the proof mass remains at the null position for all six inductance bridges. The expected intrinsic noise of the instrument is 4 x 10(exp -12)m s(exp -2) Hz(exp -1/2) for linear acceleration and 3 x 10(exp -11) rad s(exp -2) Hz(exp -1/2) for angular acceleration in 1-g environment. In 0-g, the linear acceleration sensitivity of the superconducting accelerometer could be improved by two orders of magnitude. The design and the operating principle of a laboratory prototype of the new instrument is discussed.

Characterizing fluorescent imaging properties of antibodies conjugated to IRDye800CW for use in imaging of head and neck cancer

NASA Astrophysics Data System (ADS)

Foster, Robert C.; Krell, Asher M.; Chung, Thomas K.; Warram, Jason M.; Zinn, Kurt R.; Rosenthal, Eben L.

2014-03-01

Introduction: Proteins conjugated to the near infrared (NIR) moieties for detection of head and neck cancers are being translated to the clinic. However, little is known about the fluorescent properties of IRDye800CW after conjugation to antibodies. We investigated factors that may alter the real-time observed fluorescence of antibody conjugated dye and the rate of fluorescent signal loss. Methods: Signal loss was examined using three FDA approved monoclonal antibodies conjugated to IRDye800CW (LICOR) over a period of 15 days. Temperature effects on fluorescence were examined for conjugated dye in both solution and a mouse tumor model. Samples were cooled to -20°C then warmed to predetermined temperatures up to 60°C with imaging performed using the PEARL Impulse (LI-COR) and LUNA (Novadaq) systems. Results: Short term fluorescent signal loss (< 1 hour) was linear, while long term loss (15 days) was exponential with significant increases in rate observed with light exposure and increased temperatures. Cooling of tumor tissue at -20°C was shown to significantly increase tumor fluorescence on both imaging modalities when compared to room temperature (p=0.008, p=0.019). Concurrently the ratio of tumor to background fluorescent signal (TBR) increased with decreasing temperature with statistically significant increases seen at -20°C and 4°C (p=0.0015, p=0.03). Conclusions: TBR is increased with decreasing sample temperature, suggesting that the clinical exam of fluorescently labeled tissues may be improved at cooler temperatures. Our results indicate that both the rate of signal loss and the change in fluorescence with temperature observed for IRDye800CW are independent of the conjugating antibody.

Coupling and decoupling of the accelerating units for pulsed synchronous linear accelerator

NASA Astrophysics Data System (ADS)

Shen, Yi; Liu, Yi; Ye, Mao; Zhang, Huang; Wang, Wei; Xia, Liansheng; Wang, Zhiwen; Yang, Chao; Shi, Jinshui; Zhang, Linwen; Deng, Jianjun

2017-12-01

A pulsed synchronous linear accelerator (PSLA), based on the solid-state pulse forming line, photoconductive semiconductor switch, and high gradient insulator technologies, is a novel linear accelerator. During the prototype PSLA commissioning, the energy gain of proton beams was found to be much lower than expected. In this paper, the degradation of the energy gain is explained by the circuit and cavity coupling effect of the accelerating units. The coupling effects of accelerating units are studied, and the circuit topologies of these two kinds of coupling effects are presented. Two methods utilizing inductance and membrane isolations, respectively, are proposed to reduce the circuit coupling effects. The effectiveness of the membrane isolation method is also supported by simulations. The decoupling efficiency of the metal drift tube is also researched. We carried out the experiments on circuit decoupling of the multiple accelerating cavity. The result shows that both circuit decoupling methods could increase the normalized voltage.

Cast dielectric composite linear accelerator

DOEpatents

Sanders, David M [Livermore, CA; Sampayan, Stephen [Manteca, CA; Slenes, Kirk [Albuquerque, NM; Stoller, H M [Albuquerque, NM

2009-11-10

A linear accelerator having cast dielectric composite layers integrally formed with conductor electrodes in a solventless fabrication process, with the cast dielectric composite preferably having a nanoparticle filler in an organic polymer such as a thermosetting resin. By incorporating this cast dielectric composite the dielectric constant of critical insulating layers of the transmission lines of the accelerator are increased while simultaneously maintaining high dielectric strengths for the accelerator.

A General Accelerated Degradation Model Based on the Wiener Process.

PubMed

Liu, Le; Li, Xiaoyang; Sun, Fuqiang; Wang, Ning

2016-12-06

Accelerated degradation testing (ADT) is an efficient tool to conduct material service reliability and safety evaluations by analyzing performance degradation data. Traditional stochastic process models are mainly for linear or linearization degradation paths. However, those methods are not applicable for the situations where the degradation processes cannot be linearized. Hence, in this paper, a general ADT model based on the Wiener process is proposed to solve the problem for accelerated degradation data analysis. The general model can consider the unit-to-unit variation and temporal variation of the degradation process, and is suitable for both linear and nonlinear ADT analyses with single or multiple acceleration variables. The statistical inference is given to estimate the unknown parameters in both constant stress and step stress ADT. The simulation example and two real applications demonstrate that the proposed method can yield reliable lifetime evaluation results compared with the existing linear and time-scale transformation Wiener processes in both linear and nonlinear ADT analyses.

A General Accelerated Degradation Model Based on the Wiener Process

PubMed Central

Liu, Le; Li, Xiaoyang; Sun, Fuqiang; Wang, Ning

2016-01-01

Accelerated degradation testing (ADT) is an efficient tool to conduct material service reliability and safety evaluations by analyzing performance degradation data. Traditional stochastic process models are mainly for linear or linearization degradation paths. However, those methods are not applicable for the situations where the degradation processes cannot be linearized. Hence, in this paper, a general ADT model based on the Wiener process is proposed to solve the problem for accelerated degradation data analysis. The general model can consider the unit-to-unit variation and temporal variation of the degradation process, and is suitable for both linear and nonlinear ADT analyses with single or multiple acceleration variables. The statistical inference is given to estimate the unknown parameters in both constant stress and step stress ADT. The simulation example and two real applications demonstrate that the proposed method can yield reliable lifetime evaluation results compared with the existing linear and time-scale transformation Wiener processes in both linear and nonlinear ADT analyses. PMID:28774107

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunlap, Neal E.; Cai, Jing; Biedermann, Gregory B.

Purpose: To identify the dose-volume parameters that predict the risk of chest wall (CW) pain and/or rib fracture after lung stereotactic body radiotherapy. Methods and Materials: From a combined, larger multi-institution experience, 60 consecutive patients treated with three to five fractions of stereotactic body radiotherapy for primary or metastatic peripheral lung lesions were reviewed. CW pain was assessed using the Common Toxicity Criteria for pain. Peripheral lung lesions were defined as those located within 2.5 cm of the CW. A minimal point dose of 20 Gy to the CW was required. The CW volume receiving >=20, >=30, >=40, >=50, andmore » >=60 Gy was determined and related to the risk of CW toxicity. Results: Of the 60 patients, 17 experienced Grade 3 CW pain and five rib fractures. The median interval to the onset of severe pain and/or fracture was 7.1 months. The risk of CW toxicity was fitted to the median effective concentration dose-response model. The CW volume receiving 30 Gy best predicted the risk of severe CW pain and/or rib fracture (R{sup 2} = 0.9552). A volume threshold of 30 cm{sup 3} was observed before severe pain and/or rib fracture was reported. A 30% risk of developing severe CW toxicity correlated with a CW volume of 35 cm{sup 3} receiving 30 Gy. Conclusion: The development of CW toxicity is clinically relevant, and the CW should be considered an organ at risk in treatment planning. The CW volume receiving 30 Gy in three to five fractions should be limited to <30 cm{sup 3}, if possible, to reduce the risk of toxicity without compromising tumor coverage.« less

Thermo-optical dynamics in an optically pumped Photonic Crystal nano-cavity.

PubMed

Brunstein, M; Braive, R; Hostein, R; Beveratos, A; Rober-Philip, I; Sagnes, I; Karle, T J; Yacomotti, A M; Levenson, J A; Moreau, V; Tessier, G; De Wilde, Y

2009-09-14

Linear and non-linear thermo-optical dynamical regimes were investigated in a photonic crystal cavity. First, we have measured the thermal relaxation time in an InP-based nano-cavity with quantum dots in the presence of optical pumping. The experimental method presented here allows one to obtain the dynamics of temperature in a nanocavity based on reflectivity measurements of a cw probe beam coupled through an adiabatically tapered fiber. Characteristic times of 1.0+/-0.2 micros and 0.9+/-0.2 micros for the heating and the cooling processes were obtained. Finally, thermal dynamics were also investigated in a thermo-optical bistable regime. Switch-on/off times of 2 micros and 4 micros respectively were measured, which could be explained in terms of a simple non-linear dynamical representation.

LINEAR LATTICE AND TRAJECTORY RECONSTRUCTION AND CORRECTION AT FAST LINEAR ACCELERATOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanov, A.; Edstrom, D.; Halavanau, A.

2017-07-16

The low energy part of the FAST linear accelerator based on 1.3 GHz superconducting RF cavities was successfully commissioned [1]. During commissioning, beam based model dependent methods were used to correct linear lattice and trajectory. Lattice correction algorithm is based on analysis of beam shape from profile monitors and trajectory responses to dipole correctors. Trajectory responses to field gradient variations in quadrupoles and phase variations in superconducting RF cavities were used to correct bunch offsets in quadrupoles and accelerating cavities relative to their magnetic axes. Details of used methods and experimental results are presented.

A method for evaluating dynamical friction in linear ball bearings.

PubMed

Fujii, Yusaku; Maru, Koichi; Jin, Tao; Yupapin, Preecha P; Mitatha, Somsak

2010-01-01

A method is proposed for evaluating the dynamical friction of linear bearings, whose motion is not perfectly linear due to some play in its internal mechanism. In this method, the moving part of a linear bearing is made to move freely, and the force acting on the moving part is measured as the inertial force given by the product of its mass and the acceleration of its centre of gravity. To evaluate the acceleration of its centre of gravity, the acceleration of two different points on it is measured using a dual-axis optical interferometer.

The Ability of American Football Helmets to Manage Linear Acceleration With Repeated High-Energy Impacts.

PubMed

Cournoyer, Janie; Post, Andrew; Rousseau, Philippe; Hoshizaki, Blaine

2016-03-01

Football players can receive up to 1400 head impacts per season, averaging 6.3 impacts per practice and 14.3 impacts per game. A decrease in the capacity of a helmet to manage linear acceleration with multiple impacts could increase the risk of traumatic brain injury. To investigate the ability of football helmets to manage linear acceleration with multiple high-energy impacts. Descriptive laboratory study. Laboratory. We collected linear-acceleration data for 100 impacts at 6 locations on 4 helmets of different models currently used in football. Impacts 11 to 20 were compared with impacts 91 to 100 for each of the 6 locations. Linear acceleration was greater after multiple impacts (91-100) than after the first few impacts (11-20) for the front, front-boss, rear, and top locations. However, these differences are not clinically relevant as they do not affect the risk for head injury. American football helmet performance deteriorated with multiple impacts, but this is unlikely to be a factor in head-injury causation during a game or over a season.

Phonological and Phonetic Asymmetries of Cw Combinations

ERIC Educational Resources Information Center

Suh, Yunju

2009-01-01

This thesis investigates the relationship between the phonological distribution of Cw combinations, and the acoustic/perceptual distinctiveness between syllables with plain C onsets and with Cw combination onsets. Distributional asymmetries of Cw combinations discussed in this thesis include the avoidance of Cw combinations in the labial consonant…

Applications of Electron Linear Induction Accelerators

NASA Astrophysics Data System (ADS)

Westenskow*, Glen; Chen, Yu-Jiuan

Linear Induction Accelerators (LIAs) can readily produce intense electron beams. For example, the ATA accelerator produced a 500 GW beam and the LIU-30 a 4 TW beam (see Chap. 2). Since the induction accelerator concept was proposed in the late 1950s [1, 2], there have been many proposed schemes to convert the beam power to other forms. Categories of applications that have been demonstrated for electron LIAs include:

Two Step Acceleration Process of Electrons in the Outer Van Allen Radiation Belt by Time Domain Electric Field Bursts and Large Amplitude Chorus Waves

NASA Astrophysics Data System (ADS)

Agapitov, O. V.; Mozer, F.; Artemyev, A.; Krasnoselskikh, V.; Lejosne, S.

2014-12-01

A huge number of different non-linear structures (double layers, electron holes, non-linear whistlers, etc) have been observed by the electric field experiment on the Van Allen Probes in conjunction with relativistic electron acceleration in the Earth's outer radiation belt. These structures, found as short duration (~0.1 msec) quasi-periodic bursts of electric field in the high time resolution electric field waveform, have been called Time Domain Structures (TDS). They can quite effectively interact with radiation belt electrons. Due to the trapping of electrons into these non-linear structures, they are accelerated up to ~10 keV and their pitch angles are changed, especially for low energies (˜1 keV). Large amplitude electric field perturbations cause non-linear resonant trapping of electrons into the effective potential of the TDS and these electrons are then accelerated in the non-homogeneous magnetic field. These locally accelerated electrons create the "seed population" of several keV electrons that can be accelerated by coherent, large amplitude, upper band whistler waves to MeV energies in this two step acceleration process. All the elements of this chain acceleration mechanism have been observed by the Van Allen Probes.

Seaworthy Quantum Key Distribution Design and Validation (SEAKEY)

DTIC Science & Technology

2016-05-26

shot noise limited performance for the homodyne receiver, which includes the stable CW local oscillator and balanced detector. TECHNICAL RESULTS...each piece of equipment that limited the performance of the receiver from achieving the shot noise limit. • Balanced detector: Thorlabs PDB450C o...Issue: This detector had specification for linearity to 5 mW of laser power on each detector of the pair. Upon calling the company, we were informed

Amplitude-dependent orbital period in alternating gradient accelerators

DOE PAGES

Machida, S.; Kelliher, D. J.; Edmonds, C. S.; ...

2016-03-16

Orbital period in a ring accelerator and time of flight in a linear accelerator depend on the amplitude of betatron oscillations. The variation is negligible in ordinary particle accelerators with relatively small beam emittance. In an accelerator for large emittance beams like muons and unstable nuclei, however, this effect cannot be ignored. In this study, we measured orbital period in a linear non-scaling fixed-field alternating-gradient accelerator, which is a candidate for muon acceleration, and compared it with the theoretical prediction. The good agreement between them gives important ground for the design of particle accelerators for a new generation of particlemore » and nuclear physics experiments.« less

Instrumented mouthguard acceleration analyses for head impacts in amateur rugby union players over a season of matches.

PubMed

King, Doug; Hume, Patria A; Brughelli, Matt; Gissane, Conor

2015-03-01

Direct impacts with the head (linear acceleration or pressure) and inertial loading of the head (rotational acceleration or strain) have been postulated as the 2 major mechanisms of head-related injuries such as concussion. Although data are accumulating for soccer and American football, there are no published data for nonhelmeted collision sports such as rugby union. To quantify head impacts via instrumented mouthguard acceleration analyses for rugby union players over a season of matches. Descriptive epidemiology study. Data on impact magnitude and frequency were collected with molded instrumented mouthguards worn by 38 premier amateur senior rugby players participating in the 2013 domestic season of matches. A total of 20,687 impacts >10g (range, 10.0-164.9g) were recorded over the duration of the study. The mean ± SD number of impacts per player over the duration of the season of matches was 564 ± 618, resulting in a mean ± SD of 95 ± 133 impacts to the head per player, per match over the duration of the season of matches. The impact magnitudes for linear accelerations were skewed to the lower values (Sp = 3.7 ± 0.02; P < .001), with a mean linear acceleration of 22.2 ± 16.2g. Rotational accelerations were also skewed to the lower values (Sp = 2.0 ± 0.02; P < .001), with a mean rotational acceleration of 3902.9 ± 3948.8 rad/s(2). The acceleration magnitudes and number of head impacts in amateur rugby union players over a season of matches, measured via instrumented mouthguard accelerations, were higher than for most sports previously reported. Mean linear acceleration measured over a season of matches was similar to the mean linear accelerations previously reported for youth, high school, and collegiate American football players but lower than that for female youth soccer players. Mean rotational acceleration measured over a season of matches was similar to mean rotational accelerations for youth, high school, and collegiate American football players but less than those for female youth soccer players, concussed American collegiate players, collegiate American football players, and professional American football players. © 2014 The Author(s).

Dual linear accelerator system for use in sterilization of medical disposable supplies

NASA Astrophysics Data System (ADS)

Sadat, Theo

1991-05-01

Accelerators can be used for sterilization or decontamination (medical disposables, food, plastics, hospital waste, etc.). Most of these accelerators are located in an industrial environment and must have a high availability. A dual accelerator system (composed of two accelerators) offers optimal flexibility and reliability. The main advantage of this system is "all-in all-out" because it does not need a turnover of products. Such a dual system, composed of two 10 MeV 20 kW linear accelerators (instead of one 40 kW linac), has been chosen by a Swedish company (Mölnlycke).

NOVEL TECHNIQUE OF POWER CONTROL IN MAGNETRON TRANSMITTERS FOR INTENSE ACCELERATORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazakevich, G.; Johnson, R.; Neubauer, M.

A novel concept of a high-power magnetron transmitter allowing dynamic phase and power control at the frequency of locking signal is proposed. The transmitter compensating parasitic phase and amplitude modulations inherent in Superconducting RF (SRF) cavities within closed feedback loops is intended for powering of the intensity-frontier superconducting accelerators. The con- cept uses magnetrons driven by a sufficient resonant (in- jection-locking) signal and fed by the voltage which can be below the threshold of self-excitation. This provides an extended range of power control in a single magnetron at highest efficiency minimizing the cost of RF power unit and the operationmore » cost. Proof-of-principle of the proposed concept demonstrated in pulsed and CW regimes with 2.45 GHz, 1kW magnetrons is discussed here. A conceptual scheme of the high-power transmitter allowing the dynamic wide-band phase and y power controls is presented and discussed.« less

The Use of Correcting Coils in End Magnets Accelerators

NASA Astrophysics Data System (ADS)

Kassab, L. R. P.; Gouffon, P.

1997-05-01

The end magnets of the race-track microtron booster (L.R.P. Kassab, PhD Thesis, IFUSP, 1996) , which is the second stage of the 30.0 MeV cw electron accelerator under construction at IFUSP, play a fundamental role in terms of the beam quality. Their efficiency depends on the behavior of the magnetic fields that deflect, focus and return the beam to the accelerating section. The use of correcting coils, based on the inhomogeneities of the magnetic field and attached to the pole faces, assured uniformity of 10-5. We present the performance of these coils when operating the end magnets with currents that differ from the one used in the mappings that originated the coils copper leads. For one of the magnets, adjusting conveniently the current of the correcting coils, made it possible to homogenize field distributions of different intensities, once their shapes are identical to those that originated the coils. For the other one, the shapes are smoothly changed and the coils are less efficient. This is related to intrinsic factors that determine the inhomogeneities. However, in both cases we obtained uniformity of 10-5.

Correcting coils in end magnets of accelerators

NASA Astrophysics Data System (ADS)

Kassab, L. R.; Gouffon, P.

1998-05-01

We present an empirical investigation of the correcting coils behavior used to homogenize the field distribution of the race-track microtron accelerator end magnets. These end magnets belong to the second stage of the 30.0 MeV cw electron accelerator under construction at IFUSP, the race-track microtron booster, in which the beam energy is raised from 1.97 to 5.1 MeV. The correcting coils are attached to the pole faces and are based on the inhomogeneities of the magnetic field measured. The performance of these coils, when operating the end magnets with currents that differ by +/-10% from the one used in the mappings that originated the coils copper leads, is presented. For one of the magnets, adjusting conveniently the current of the correcting coils makes it possible to homogenize field distributions of different intensities, once their shapes are practically identical to those that originated the coils. For the other one, the shapes are changed and the coils are less efficient. This is related to intrinsic factors that determine the inhomogeneities. However, we obtained uniformity of 0.001% in both cases.

Monopole HOMs Dumping in the LCLS-II 1.3 GHz Structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lunin, Andrei; Khabiboulline, Timergali; Solyak, Nikolay

2017-05-01

Developing an upgrade of Linac Coherent Light Source (LCLS-II) is currently underway. The central part of LCLS-II is a continuous wave superconducting RF (CW SRF) electron linac. High order modes (HOMs) excited in SRF structures by passing beam may deteriorate beam quality and affect beam stability. In this paper we report the simulation results of monopole High Order Modes (HOM) spectrum in the 1.3 GHz accelerating structure. Optimum parameters of the HOM feedthrough are suggested for minimizing RF losses on the HOM antenna tip and for preserving an efficiency of monopole HOMs damping simultaneously.

Duty factor variation possibility from 1% to 100% with PKU microwave driven Cs-free volume H{sup −} sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, S. X., E-mail: sxpeng@pku.edu.cn; Zhang, T.; Ren, H. T.

Microwave driven cesium-free volume H{sup −} sources, that have the ability to deliver tens of mA H{sup −} at 35 keV both in CW and 10% duty factor (100 Hz/1 ms), were developed at Peking University (PKU) [S. X. Peng et al., in Proceeding of IPAC 2015, WEPWA027, Richmond, Virginia, USA, 3–8 May 2015]. Recently, special efforts were paid on the investigation of duty factor variation possibility from 1% to 100% with them. Most of the experiments were carried out with a pulsed length (τ) of 1 ms and different intervals of 99 ms, 49 ms, 39 ms, 29 ms,more » 19 ms, 9 ms, 4 ms, 2 ms, 1 ms, 0.5 ms, and 0 ms, respectively. Other experiments were focused on CW operation and fixed duty factor of 1%. Experimental results prove that PKU H{sup −} sources can deliver tens of mA H{sup −} at duty factor from 1% to 100%. The RF power efficiency increases steadily with the increasing of duty factor from 1% to CW at a fixed pulsed length. Under a given duty factor and pulsed length, RF power efficiency keeps constant and the H{sup −} current increases with RF power linearly. Details will be presented in the paper.« less

Optically stimulated luminescence and thermoluminescence efficiencies for high-energy heavy charged particle irradiation in Al2O3:C.

PubMed

Yukihara, E G; Gaza, R; McKeever, S W S; Soares, C G

2004-02-01

The thermally and optically stimulated luminescence (TL and OSL) response to high energy heavy-charged particles (HCPs) was investigated for two types of Al2O3:C luminescence dosimeters. The OSL signal was measured in both continuous-wave (CW) and pulsed mode. The efficiencies of the HCPs at producing TL or OSL, relative to gamma radiation, were obtained using four different HCPs beams (150 MeV/u 4He, 400 MeV/u 12C, 490 MeV/u 28Si, and 500 MeV/u 56Fe). The efficiencies were determined as a function of the HCP linear energy transfer (LET). It was observed that the efficiency depends on the type of detector, measurement technique, and the choice of signal. Additionally, it is shown that the shape of the CW-OSL decay curve from Al2O3:C depends on the type of radiation, and, in principle, this can be used to extract information concerning the LET of an unknown radiation field. The response of the dosimeters to low-LET radiation was also investigated for doses in the range from about 1-1000 Gy. These data were used to explain the different efficiency values obtained for the different materials and techniques, as well as the LET dependence of the CW-OSL decay curve shape. c2003 Elsevier Ltd. All rights reserved.

Is supervision necessary? Examining the effects of internet-based CBT training with and without supervision.

PubMed

Rakovshik, Sarah G; McManus, Freda; Vazquez-Montes, Maria; Muse, Kate; Ougrin, Dennis

2016-03-01

To investigate the effect of Internet-based training (IBT), with and without supervision, on therapists' (N = 61) cognitive-behavioral therapy (CBT) skills in routine clinical practice. Participants were randomized into 3 conditions: (1) Internet-based training with use of a consultation worksheet (IBT-CW); (2) Internet-based training with CBT supervision via Skype (IBT-S); and (3) "delayed-training" controls (DTs), who did not receive the training until all data collection was completed. The IBT participants received access to training over a period of 3 months. CBT skills were evaluated at pre-, mid- and posttraining/wait using assessor competence ratings of recorded therapy sessions. Hierarchical linear analysis revealed that the IBT-S participants had significantly greater CBT competence at posttraining than did IBT-CW and DT participants at both the mid- and posttraining/wait assessment points. There were no significant differences between IBT-CW and the delayed (no)-training DTs. IBT programs that include supervision may be a scalable and effective method of disseminating CBT into routine clinical practice, particularly for populations without ready access to more-traditional "live" methods of training. There was no evidence for a significant effect of IBT without supervision over a nontraining control, suggesting that merely providing access to IBT programs may not be an effective method of disseminating CBT to routine clinical practice. (c) 2016 APA, all rights reserved).

Ring laser having an output at a single frequency

DOEpatents

Hackell, Lloyd A.

1991-01-01

A ring laser is disclosed that produces a single frequency of laser radiation in either the pulsed mode of operation or the continuous waveform (cw) mode of operation. The laser comprises a ring laser in a bowtie configuration, a birefringent gain material such as Nd:YLF, an improved optical diode that supports laser oscillation having a desired direction of travel and linear polarization, and a Q-switch. An output coupler (mirror) having a high reflectivity, such as 94%, is disclosed. Also disclosed is a self-seeded method of operation in which the laser can provide a pulse or a series of pulses of high power laser radiation at a consistent single frequency with a high degree of amplitude stability and temporal stability. In operation, the laser is operated in continuous waveform (cw) at a low power output with the Q-switch introducing a loss into the resonating cavity. Pumping is continued at a high level, causing the gain material to store energy. When a pulse is desired, the Q-switch is actuated to substantially reduce the losses so that a pulse can build up based on the low level cw oscillation. The pulse quickly builds, using the stored energy in the gain medium to provide a high power output pulse. The process may be repeated to provide a series of high power pulses of a consistent single frequency.

Optically stimulated luminescence and thermoluminescence efficiencies for high-energy heavy charged particle irradiation in Al2O3:C

NASA Technical Reports Server (NTRS)

Yukihara, E. G.; Gaza, R.; McKeever, S. W. S.; Soares, C. G.

2004-01-01

The thermally and optically stimulated luminescence (TL and OSL) response to high energy heavy-charged particles (HCPs) was investigated for two types of Al2O3:C luminescence dosimeters. The OSL signal was measured in both continuous-wave (CW) and pulsed mode. The efficiencies of the HCPs at producing TL or OSL, relative to gamma radiation, were obtained using four different HCPs beams (150 MeV/u 4He, 400 MeV/u 12C, 490 MeV/u 28Si, and 500 MeV/u 56Fe). The efficiencies were determined as a function of the HCP linear energy transfer (LET). It was observed that the efficiency depends on the type of detector, measurement technique, and the choice of signal. Additionally, it is shown that the shape of the CW-OSL decay curve from Al2O3:C depends on the type of radiation, and, in principle, this can be used to extract information concerning the LET of an unknown radiation field. The response of the dosimeters to low-LET radiation was also investigated for doses in the range from about 1-1000 Gy. These data were used to explain the different efficiency values obtained for the different materials and techniques, as well as the LET dependence of the CW-OSL decay curve shape. c2003 Elsevier Ltd. All rights reserved.

Cavity-enhanced resonant photoacoustic spectroscopy with optical feedback cw diode lasers: A novel technique for ultratrace gas analysis and high-resolution spectroscopy.

PubMed

Hippler, Michael; Mohr, Christian; Keen, Katherine A; McNaghten, Edward D

2010-07-28

Cavity-enhanced resonant photoacoustic spectroscopy with optical feedback cw diode lasers (OF-CERPAS) is introduced as a novel technique for ultratrace gas analysis and high-resolution spectroscopy. In the scheme, a single-mode cw diode laser (3 mW, 635 nm) is coupled into a high-finesse linear cavity and stabilized to the cavity by optical feedback. Inside the cavity, a build-up of laser power to at least 2.5 W occurs. Absorbing gas phase species inside the cavity are detected with high sensitivity by the photoacoustic effect using a microphone embedded in the cavity. To increase sensitivity further, coupling into the cavity is modulated at a frequency corresponding to a longitudinal resonance of an organ pipe acoustic resonator (f=1.35 kHz and Q approximately 10). The technique has been characterized by measuring very weak water overtone transitions near 635 nm. Normalized noise-equivalent absorption coefficients are determined as alpha approximately 4.4x10(-9) cm(-1) s(1/2) (1 s integration time) and 2.6x10(-11) cm(-1) s(1/2) W (1 s integration time and 1 W laser power). These sensitivities compare favorably with existing state-of-the-art techniques. As an advantage, OF-CERPAS is a "zero-background" method which increases selectivity and sensitivity, and its sensitivity scales with laser power.

Acceleration modules in linear induction accelerators

NASA Astrophysics Data System (ADS)

Wang, Shao-Heng; Deng, Jian-Jun

2014-05-01

The Linear Induction Accelerator (LIA) is a unique type of accelerator that is capable of accelerating kilo-Ampere charged particle current to tens of MeV energy. The present development of LIA in MHz bursting mode and the successful application into a synchrotron have broadened LIA's usage scope. Although the transformer model is widely used to explain the acceleration mechanism of LIAs, it is not appropriate to consider the induction electric field as the field which accelerates charged particles for many modern LIAs. We have examined the transition of the magnetic cores' functions during the LIA acceleration modules' evolution, distinguished transformer type and transmission line type LIA acceleration modules, and re-considered several related issues based on transmission line type LIA acceleration module. This clarified understanding should help in the further development and design of LIA acceleration modules.

Classical-trajectory simulation of accelerating neutral atoms with polarized intense laser pulses

NASA Astrophysics Data System (ADS)

Xia, Q. Z.; Fu, L. B.; Liu, J.

2013-03-01

In the present paper, we perform the classical trajectory Monte Carlo simulation of the complex dynamics of accelerating neutral atoms with linearly or circularly polarized intense laser pulses. Our simulations involve the ion motion as well as the tunneling ionization and the scattering dynamics of valence electron in the combined Coulomb and electromagnetic fields, for both helium (He) and magnesium (Mg). We show that for He atoms, only linearly polarized lasers can effectively accelerate the atoms, while for Mg atoms, we find that both linearly and circularly polarized lasers can successively accelerate the atoms. The underlying mechanism is discussed and the subcycle dynamics of accelerating trajectories is investigated. We have compared our theoretical results with a recent experiment [Eichmann Nature (London)NATUAS0028-083610.1038/nature08481 461, 1261 (2009)].

[A study of magnetic shielding design for a magnetic resonance imaging linac system].

PubMed

Zhang, Zheshun; Chen, Wenjing; Qiu, Yang; Zhu, Jianming

2017-12-01

One of the main technical challenges when integrating magnetic resonance imaging (MRI) systems with medical linear accelerator is the strong interference of fringe magnetic fields from the MRI system with the electron beams of linear accelerator, making the linear accelerator not to work properly. In order to minimize the interference of magnetic fields, a magnetic shielding cylinder with an open structure made of high permeability materials is designed. ANSYS Maxwell was used to simulate Helmholtz coil which generate uniform magnetic field instead of the fringe magnetic fields which affect accelerator gun. The parameters of shielding tube, such as permeability, radius, length, side thickness, bottom thickness and fringe magnetic fields strength are simulated, and the data is processed by MATLAB to compare the shielding performance. This article gives out a list of magnetic shielding effectiveness with different side thickness and bottom thickness under the optimal radius and length, which showes that this design can meet the shielding requirement for the MRI-linear accelerator system.

Differences in 1D electron plasma wake field acceleration in MeV versus GeV and linear versus blowout regimes

NASA Astrophysics Data System (ADS)

Tsiklauri, David

2018-03-01

In some laboratory and most astrophysical situations, plasma wake-field acceleration of electrons is one dimensional, i.e., variation transverse to the beam's motion can be ignored. Thus, one dimensional, particle-in-cell (PIC), fully electromagnetic simulations of electron plasma wake field acceleration are conducted in order to study the differences in electron plasma wake field acceleration in MeV versus GeV and linear versus blowout regimes. First, we show that caution needs to be taken when using fluid simulations, as PIC simulations prove that an approximation for an electron bunch not to evolve in time for a few hundred plasma periods only applies when it is sufficiently relativistic. This conclusion is true irrespective of the plasma temperature. We find that in the linear regime and GeV energies, the accelerating electric field generated by the plasma wake is similar to the linear and MeV regimes. However, because GeV energy driving bunch stays intact for a much longer time, the final acceleration energies are much larger in the GeV energies case. In the GeV energy range and blowout regime, the wake's accelerating electric field is much larger in amplitude compared with the linear case and also plasma wake geometrical size is much larger. Thus, the correct positioning of the trailing bunch is needed to achieve the efficient acceleration. For the considered case, optimally, there should be approximately (90-100)c/ωpe distance between the trailing and driving electron bunches in the GeV blowout regime.

Distinguishing familiarity from fluency for the compound word pair effect in associative recognition.

PubMed

Ahmad, Fahad N; Hockley, William E

2017-09-01

We examined whether processing fluency contributes to associative recognition of unitized pre-experimental associations. In Experiments 1A and 1B, we minimized perceptual fluency by presenting each word of pairs on separate screens at both study and test, yet the compound word (CW) effect (i.e., hit and false-alarm rates greater for CW pairs with no difference in discrimination) did not reduce. In Experiments 2A and 2B, conceptual fluency was examined by comparing transparent (e.g., hand bag) and opaque (e.g., rag time) CW pairs in lexical decision and associative recognition tasks. Lexical decision was faster for transparent CWs (Experiment 2A) but in associative recognition, the CW effect did not differ by CW pair type (Experiment 2B). In Experiments 3A and 3B, we examined whether priming that increases processing fluency would influence the CW effect. In Experiment 3A, CW and non-compound word pairs were preceded with matched and mismatched primes at test in an associative recognition task. In Experiment 3B, only transparent and opaque CW pairs were presented. Results showed that presenting matched versus mismatched primes at test did not influence the CW effect. The CW effect in yes-no associative recognition is due to reliance on enhanced familiarity of unitized CW pairs.

Dose-volume parameters predict for the development of chest wall pain after stereotactic body radiation for lung cancer.

PubMed

Mutter, Robert W; Liu, Fan; Abreu, Andres; Yorke, Ellen; Jackson, Andrew; Rosenzweig, Kenneth E

2012-04-01

Chest wall (CW) pain has recently been recognized as an important adverse effect of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). We developed a dose-volume model to predict the development of this toxicity. A total of 126 patients with primary, clinically node-negative NSCLC received three to five fractions of SBRT to doses of 40-60 Gy and were prospectively followed. The dose-absolute volume histograms of two different definitions of the CW as an organ at risk (CW3cm and CW2cm) were examined for all 126 patients. With a median follow-up of 16 months, the 2-year estimated actuarial incidence of Grade ≥ 2 CW pain was 39%. The median time to onset of Grade ≥ 2 CW pain (National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0) was 9 months. There was no predictive advantage for biologically corrected dose over physical dose. Neither fraction number (p = 0.07) nor prescription dose (p = 0.07) were significantly correlated with the development of Grade ≥ 2 CW pain. Cox Proportional Hazards analysis identified significant correlation with a broad range of dose-volume combinations, with the CW volume receiving 30 Gy (V30) as one of the strongest predictors (p < 0.001). CW2cm consistently enabled better prediction of CW toxicity. When a physical dose of 30 Gy was received by more than 70 cm(3) of CW2cm, there was a significant correlation with Grade ≥ 2 CW pain (p = 0.004). CW toxicity after SBRT is common and long-term follow-up is needed to identify affected patients. A volume of CW ≥ 70 cm(3) receiving 30 Gy is significantly correlated with Grade ≥ 2 CW pain. We are currently applying this constraint at our institution for patients receiving thoracic SBRT. An actuarial atlas of our data is provided as an electronic supplement to facilitate data-sharing and meta-analysis relating to CW pain. Copyright © 2012 Elsevier Inc. All rights reserved.

Dose-Volume Parameters Predict for the Development of Chest Wall Pain After Stereotactic Body Radiation for Lung Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mutter, Robert W.; Liu Fan; Abreu, Andres

Purpose: Chest wall (CW) pain has recently been recognized as an important adverse effect of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). We developed a dose-volume model to predict the development of this toxicity. Methods and Materials: A total of 126 patients with primary, clinically node-negative NSCLC received three to five fractions of SBRT to doses of 40-60 Gy and were prospectively followed. The dose-absolute volume histograms of two different definitions of the CW as an organ at risk (CW3cm and CW2cm) were examined for all 126 patients. Results: With a median follow-up of 16 months, themore » 2-year estimated actuarial incidence of Grade {>=} 2 CW pain was 39%. The median time to onset of Grade {>=} 2 CW pain (National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3.0) was 9 months. There was no predictive advantage for biologically corrected dose over physical dose. Neither fraction number (p = 0.07) nor prescription dose (p = 0.07) were significantly correlated with the development of Grade {>=} 2 CW pain. Cox Proportional Hazards analysis identified significant correlation with a broad range of dose-volume combinations, with the CW volume receiving 30 Gy (V30) as one of the strongest predictors (p < 0.001). CW2cm consistently enabled better prediction of CW toxicity. When a physical dose of 30 Gy was received by more than 70 cm{sup 3} of CW2cm, there was a significant correlation with Grade {>=} 2 CW pain (p = 0.004). Conclusions: CW toxicity after SBRT is common and long-term follow-up is needed to identify affected patients. A volume of CW {>=} 70 cm{sup 3} receiving 30 Gy is significantly correlated with Grade {>=} 2 CW pain. We are currently applying this constraint at our institution for patients receiving thoracic SBRT. An actuarial atlas of our data is provided as an electronic supplement to facilitate data-sharing and meta-analysis relating to CW pain.« less

Photoelectron linear accelerator for producing a low emittance polarized electron beam

DOEpatents

Yu, David U.; Clendenin, James E.; Kirby, Robert E.

2004-06-01

A photoelectron linear accelerator for producing a low emittance polarized electric beam. The accelerator includes a tube having an inner wall, the inner tube wall being coated by a getter material. A portable, or demountable, cathode plug is mounted within said tube, the surface of said cathode having a semiconductor material formed thereon.

Broadband Energy Harvester Using Non-linear Polymer Spring and Electromagnetic/Triboelectric Hybrid Mechanism

PubMed Central

Gupta, Rahul Kumar; Shi, Qiongfeng; Dhakar, Lokesh; Wang, Tao; Heng, Chun Huat; Lee, Chengkuo

2017-01-01

Over the years, several approaches have been devised to widen the operating bandwidth, but most of them can only be triggered at high accelerations. In this work, we investigate a broadband energy harvester based on combination of non-linear stiffening effect and multimodal energy harvesting to obtain high bandwidth over wide range of accelerations (0.1 g–2.0 g). In order to achieve broadband behavior, a polymer based spring exhibiting multimodal energy harvesting is used. Besides, non-linear stiffening effect is introduced by using mechanical stoppers. At low accelerations (<0.5 g), the nearby mode frequencies of polymer spring contribute to broadening characteristics, while proof mass engages with mechanical stoppers to introduce broadening by non-linear stiffening at higher accelerations. The electromagnetic mechanism is employed in this design to enhance its output at low accelerations when triboelectric output is negligible. Our device displays bandwidth of 40 Hz even at low acceleration of 0.1 g and it is increased up to 68 Hz at 2 g. When non-linear stiffening is used along with multimodal energy-harvesting, the obtained bandwidth increases from 23 Hz to 68 Hz with percentage increment of 295% at 1.8 g. Further, we have demonstrated the triboelectric output measured as acceleration sensing signals in terms of voltage and current sensitivity of 4.7 Vg−1 and 19.7 nAg−1, respectively. PMID:28120924

The influence of acceleration loading curve characteristics on traumatic brain injury.

PubMed

Post, Andrew; Blaine Hoshizaki, T; Gilchrist, Michael D; Brien, Susan; Cusimano, Michael D; Marshall, Shawn

2014-03-21

To prevent brain trauma, understanding the mechanism of injury is essential. Once the mechanism of brain injury has been identified, prevention technologies could then be developed to aid in their prevention. The incidence of brain injury is linked to how the kinematics of a brain injury event affects the internal structures of the brain. As a result it is essential that an attempt be made to describe how the characteristics of the linear and rotational acceleration influence specific traumatic brain injury lesions. As a result, the purpose of this study was to examine the influence of the characteristics of linear and rotational acceleration pulses and how they account for the variance in predicting the outcome of TBI lesions, namely contusion, subdural hematoma (SDH), subarachnoid hemorrhage (SAH), and epidural hematoma (EDH) using a principal components analysis (PCA). Monorail impacts were conducted which simulated falls which caused the TBI lesions. From these reconstructions, the characteristics of the linear and rotational acceleration were determined and used for a PCA analysis. The results indicated that peak resultant acceleration variables did not account for any of the variance in predicting TBI lesions. The majority of the variance was accounted for by duration of the resultant and component linear and rotational acceleration. In addition, the components of linear and rotational acceleration characteristics on the x, y, and z axes accounted for the majority of the remainder of the variance after duration. Copyright © 2014 Elsevier Ltd. All rights reserved.

Broadband Energy Harvester Using Non-linear Polymer Spring and Electromagnetic/Triboelectric Hybrid Mechanism

NASA Astrophysics Data System (ADS)

Gupta, Rahul Kumar; Shi, Qiongfeng; Dhakar, Lokesh; Wang, Tao; Heng, Chun Huat; Lee, Chengkuo

2017-01-01

Over the years, several approaches have been devised to widen the operating bandwidth, but most of them can only be triggered at high accelerations. In this work, we investigate a broadband energy harvester based on combination of non-linear stiffening effect and multimodal energy harvesting to obtain high bandwidth over wide range of accelerations (0.1 g-2.0 g). In order to achieve broadband behavior, a polymer based spring exhibiting multimodal energy harvesting is used. Besides, non-linear stiffening effect is introduced by using mechanical stoppers. At low accelerations (<0.5 g), the nearby mode frequencies of polymer spring contribute to broadening characteristics, while proof mass engages with mechanical stoppers to introduce broadening by non-linear stiffening at higher accelerations. The electromagnetic mechanism is employed in this design to enhance its output at low accelerations when triboelectric output is negligible. Our device displays bandwidth of 40 Hz even at low acceleration of 0.1 g and it is increased up to 68 Hz at 2 g. When non-linear stiffening is used along with multimodal energy-harvesting, the obtained bandwidth increases from 23 Hz to 68 Hz with percentage increment of 295% at 1.8 g. Further, we have demonstrated the triboelectric output measured as acceleration sensing signals in terms of voltage and current sensitivity of 4.7 Vg-1 and 19.7 nAg-1, respectively.

Safety of panitumumab-IRDye800CW and cetuximab-IRDye800CW for fluorescence-guided surgical navigation in head and neck cancers.

PubMed

Gao, Rebecca W; Teraphongphom, Nutte; de Boer, Esther; van den Berg, Nynke S; Divi, Vasu; Kaplan, Michael J; Oberhelman, Nicholas J; Hong, Steven S; Capes, Elissa; Colevas, A Dimitrios; Warram, Jason M; Rosenthal, Eben L

2018-01-01

Purpose: To demonstrate the safety and feasibility of leveraging therapeutic antibodies for surgical imaging. Procedures: We conducted two phase I trials for anti-epidermal growth factor receptor antibodies cetuximab-IRDye800CW (n=12) and panitumumab-IRDye800CW (n=15). Adults with biopsy-confirmed head and neck squamous cell carcinoma scheduled for standard-of-care surgery were eligible. For cetuximab-IRDye800CW, cohort 1 was intravenously infused with 2.5 mg/m 2 , cohort 2 received 25 mg/m 2 , and cohort 3 received 62.5 mg/m 2 . For panitumumab-IRDye800CW, cohorts received 0.06 mg/kg, 0.5 mg/kg, and 1 mg/kg, respectively. Electrocardiograms and blood samples were obtained, and patients were followed for 30 days post-study drug infusion. Results: Both fluorescently labeled antibodies had similar pharmacodynamic properties and minimal toxicities. Two infusion reactions occurred with cetuximab and none with panitumumab. There were no grade 2 or higher toxicities attributable to cetuximab-IRDye800CW or panitumumab-IRDye800CW; fifteen grade 1 adverse events occurred with cetuximab-IRDye800CW, and one grade 1 occurred with panitumumab-IRDye800CW. There were no significant differences in QTc prolongation between the two trials (p=0.8). Conclusions: Panitumumab-IRDye800CW and cetuximab-IRDye800CW have toxicity and pharmacodynamic profiles that match the parent compound, suggesting that other therapeutic antibodies may be repurposed as imaging agents with limited preclinical toxicology data.

Technical Note: Mobile accelerator guidance using an optical tracker during docking in IOERT procedures.

PubMed

Marinetto, Eugenio; Victores, Juan González; García-Sevilla, Mónica; Muñoz, Mercedes; Calvo, Felipe Ángel; Balaguer, Carlos; Desco, Manuel; Pascau, Javier

2017-10-01

Intraoperative electron radiation therapy (IOERT) involves the delivery of a high radiation dose during tumor resection in a shorter time than other radiation techniques, thus improving local control of tumors. However, a linear accelerator device is needed to produce the beam safely. Mobile linear accelerators have been designed as dedicated units that can be moved into the operating room and deliver radiation in situ. Correct and safe dose delivery is a key concern when using mobile accelerators. The applicator is commonly fixed to the patient's bed to ensure that the dose is delivered to the prescribed location, and the mobile accelerator is moved to dock the applicator to the radiation beam output (gantry). In a typical clinical set-up, this task is time-consuming because of safety requirements and the limited degree of freedom of the gantry. The objective of this study was to present a navigation solution based on optical tracking for guidance of docking to improve safety and reduce procedure time. We used an optical tracker attached to the mobile linear accelerator to track the prescribed localization of the radiation collimator inside the operating room. Using this information, the integrated navigation system developed computes the movements that the mobile linear accelerator needs to perform to align the applicator and the radiation gantry and warns the physician if docking is unrealizable according to the available degrees of freedom of the mobile linear accelerator. Furthermore, we coded a software application that connects all the necessary functioning elements and provides a user interface for the system calibration and the docking guidance. The system could safeguard against the spatial limitations of the operating room, calculate the optimal arrangement of the accelerator and reduce the docking time in computer simulations and experimental setups. The system could be used to guide docking with any commercial linear accelerator. We believe that the docking navigator we present is a major contribution to IOERT, where docking is critical when attempting to reduce surgical time, ensure patient safety and guarantee that the treatment administered follows the radiation oncologist's prescription. © 2017 American Association of Physicists in Medicine.

Efficient Low-Voltage Operation of a CW Gyrotron Oscillator at 233 GHz.

PubMed

Hornstein, Melissa K; Bajaj, Vikram S; Griffin, Robert G; Temkin, Richard J

2007-02-01

The gyrotron oscillator is a source of high average power millimeter-wave through terahertz radiation. In this paper, we report low beam power and high-efficiency operation of a tunable gyrotron oscillator at 233 GHz. The low-voltage operating mode provides a path to further miniaturization of the gyrotron through reduction in the size of the electron gun, power supply, collector, and cooling system, which will benefit industrial and scientific applications requiring portability. Detailed studies of low-voltage operation in the TE(2) (,) (3) (,) (1) mode reveal that the mode can be excited with less than 7 W of beam power at 3.5 kV. During CW operation with 3.5-kV beam voltage and 50-mA beam current, the gyrotron generates 12 W of RF power at 233.2 GHz. The EGUN electron optics code describes the low-voltage operation of the electron gun. Using gun-operating parameters derived from EGUN simulations, we show that a linear theory adequately predicts the low experimental starting currents.

Efficient Low-Voltage Operation of a CW Gyrotron Oscillator at 233 GHz

PubMed Central

Hornstein, Melissa K.; Bajaj, Vikram S.; Griffin, Robert G.; Temkin, Richard J.

2007-01-01

The gyrotron oscillator is a source of high average power millimeter-wave through terahertz radiation. In this paper, we report low beam power and high-efficiency operation of a tunable gyrotron oscillator at 233 GHz. The low-voltage operating mode provides a path to further miniaturization of the gyrotron through reduction in the size of the electron gun, power supply, collector, and cooling system, which will benefit industrial and scientific applications requiring portability. Detailed studies of low-voltage operation in the TE2,3,1 mode reveal that the mode can be excited with less than 7 W of beam power at 3.5 kV. During CW operation with 3.5-kV beam voltage and 50-mA beam current, the gyrotron generates 12 W of RF power at 233.2 GHz. The EGUN electron optics code describes the low-voltage operation of the electron gun. Using gun-operating parameters derived from EGUN simulations, we show that a linear theory adequately predicts the low experimental starting currents. PMID:17687412

Impact attenuation of protective boxing and taekwondo headgear.

PubMed

O'Sullivan, David M; Fife, Gabriel P

2016-11-01

This study aimed to compare the impact attenuation performance of boxing and taekwondo headgear in terms of peak linear and rotational acceleration. To measure the impact attenuation of headgear, a standardized (American Society for Testing and Materials (ASTM) F-2397) martial arts headgear striker was used to impart impacts to a 50th Percentile Male Hybrid III Crash Test Dummy head and neck complex. Two boxing (Adidas and Greenhill) and two taekwondo (Adidas and Nike) headgear, approved by the Association Internationale de Boxe Amateur and the World Taekwondo Federation (WTF), were selected. Each of the selected headgear was fitted to the Hybrid III head and subsequently subjected to five impacts at the front and side with a maximum impact interim time of 60 seconds by the rotating striker at 8 ± 0.3 m/s. Linear and rotational acceleration were recorded at 10,000 Hz. There were significant interactions of the impact location and brand on the rotational acceleration, F(3,40) = 6.7, p < .05. There were significant main effects of both impact location F(1,40) = 9.07, p < .05 and headgear brand F(3,40) = 9.9, p < .05 on the linear acceleration. Pairwise comparisons show significant differences between the front and side for both linear and rotational acceleration. The headgear tested failed the ASTM high impact test requirement to reduce the linear acceleration to below a threshold of 150 g. Further development of headgear to reduce impact linear and rotational acceleration magnitudes should be called for by the relevant sport governing bodies and initiated by headgear manufactures.

KLYNAC: Compact linear accelerator with integrated power supply

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malyzhenkov, Alexander

Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scienti c community is working towards improving the quality of the accelerated beam and its parameters while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype, resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RFmore » source, an accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simpli ed theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using particle-in-cell simulation studies for mono- resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.« less

Klynac: Compact Linear Accelerator with Integrated Power Supply

NASA Astrophysics Data System (ADS)

Malyzhenkov, A. V.

Accelerators and accelerator-based light sources have a wide range of applications in science, engineering technology and medicine. Today the scientific community is working towards improving the quality of the accelerated beam and its parameters, while trying to develop technology for reducing accelerator size. This work describes a design of a compact linear accelerator (linac) prototype: resonant Klynac device, which is a combined linear accelerator and its power supply - klystron. The intended purpose of a Klynac device is to provide a compact and inexpensive alternative to a conventional 1 to 6 MeV accelerator, which typically requires a separate RF source, accelerator itself and all the associated hardware. Because the Klynac is a single structure, it has the potential to be much less sensitive to temperature variations than a system with separate klystron and linac. We start by introducing a simplified theoretical model for a Klynac device. We then demonstrate how a prototype is designed step-by-step using Particle-In-Cell simulation studies for mono-resonant and bi-resonant structures. Finally, we discuss design options from a stability point of view and required input power as well as behavior of competing modes for the actual built device.

Pros and Cons of the Acceleration Scheme (NF-IDS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bogacz, Alex; Bogacz, Slawomir

The overall goal of the acceleration systems: large acceptance acceleration to 25 GeV and beam shaping can be accomplished by various fixed field accelerators at different stages. They involve three superconducting linacs: a single pass linear Pre-accelerator followed by a pair of multi-pass Recirculating Linear Accelerators (RLA) and finally a nonâ scaling FFAG ring. The present baseline acceleration scenario has been optimized to take maximum advantage of appropriate acceleration scheme at a given stage. Pros and cons of various stages are discussed here in detail. The solenoid based Pre-accelerator offers very large acceptance and facilitates correction of energy gain acrossmore » the bunch and significant longitudinal compression trough induced synchrotron motion. However, far off-crest acceleration reduces the effective acceleration gradient and adds complexity through the requirement of individual RF phase control for each cavity. Close proximity of strong solenoids and superc« less

Electron acceleration via magnetic island coalescence

NASA Astrophysics Data System (ADS)

Shinohara, I.; Yumura, T.; Tanaka, K. G.; Fujimoto, M.

2009-06-01

Electron acceleration via fast magnetic island coalescence that happens as quick magnetic reconnection triggering (QMRT) proceeds has been studied. We have carried out a three-dimensional full kinetic simulation of the Harris current sheet with a large enough simulation run for two magnetic islands coalescence. Due to the strong inductive electric field associated with the non-linear evolution of the lower-hybrid-drift instability and the magnetic island coalescence process observed in the non-linear stage of the collisionless tearing mode, electrons are significantly accelerated at around the neutral sheet and the subsequent X-line. The accelerated meandering electrons generated by the non-linear evolution of the lower-hybrid-drift instability are resulted in QMRT, and QMRT leads to fast magnetic island coalescence. As a whole, the reconnection triggering and its transition to large-scale structure work as an effective electron accelerator.

Laser-plasma-based linear collider using hollow plasma channels

DOE PAGES

Schroeder, C. B.; Benedetti, C.; Esarey, E.; ...

2016-03-03

A linear electron–positron collider based on laser-plasma accelerators using hollow plasma channels is considered. Laser propagation and energy depletion in the hollow channel is discussed, as well as the overall efficiency of the laser-plasma accelerator. Example parameters are presented for a 1-TeV and 3-TeV center-of-mass collider based on laser-plasma accelerators.

Electron stripping processes of H⁻ ion beam in the 80 kV high voltage extraction column and low energy beam transport line at LANSCE.

PubMed

Draganic, I N

2016-02-01

Basic vacuum calculations were performed for various operating conditions of the Los Alamos National Neutron Science H(-) Cockcroft-Walton (CW) injector and the Ion Source Test Stand (ISTS). The vacuum pressure was estimated for both the CW and ISTS at five different points: (1) inside the H(-) ion source, (2) in front of the Pierce electrode, (3) at the extraction electrode, (4) at the column electrode, and (5) at the ground electrode. A static vacuum analysis of residual gases and the working hydrogen gas was completed for the normal ion source working regime. Gas density and partial pressure were estimated for the injected hydrogen gas. The attenuation of H(-) beam current and generation of electron current in the high voltage acceleration columns and low energy beam transport lines were calculated. The interaction of H(-) ions on molecular hydrogen (H2) is discussed as a dominant collision process in describing electron stripping rates. These results are used to estimate the observed increase in the ratio of electrons to H(-) ion beam in the ISTS beam transport line.

Nanoslit cavity plasmonic modes and built-in fields enhance the CW THz radiation in an unbiased antennaless photomixers array.

PubMed

Mohammad-Zamani, Mohammad Javad; Neshat, Mohammad; Moravvej-Farshi, Mohammad Kazem

2016-01-15

A new generation unbiased antennaless CW terahertz (THz) photomixer emitters array made of asymmetric metal-semiconductor-metal (MSM) gratings with a subwavelength pitch, operating in the optical near-field regime, is proposed. We take advantage of size effects in near-field optics and electrostatics to demonstrate the possibility of enhancing the THz power by 4 orders of magnitude, compared to a similar unbiased antennaless array of the same size that operates in the far-field regime. We show that, with the appropriate choice of grating parameters in such THz sources, the first plasmonic resonant cavity mode in the nanoslit between two adjacent MSMs can enhance the optical near-field absorption and, hence, the generation of photocarriers under the slit in the active medium. These photocarriers, on the other hand, are accelerated by the large built-in electric field sustained under the nanoslits by two dissimilar Schottky barriers to create the desired large THz power that is mainly radiated downward. The proposed structure can be tuned in a broadband frequency range of 0.1-3 THz, with output power increasing with frequency.

Safety of panitumumab-IRDye800CW and cetuximab-IRDye800CW for fluorescence-guided surgical navigation in head and neck cancers

PubMed Central

Gao, Rebecca W.; Teraphongphom, Nutte; de Boer, Esther; van den Berg, Nynke S.; Divi, Vasu; Kaplan, Michael J.; Oberhelman, Nicholas J.; Hong, Steven S.; Capes, Elissa; Colevas, A. Dimitrios; Warram, Jason M.; Rosenthal, Eben L.

2018-01-01

Purpose: To demonstrate the safety and feasibility of leveraging therapeutic antibodies for surgical imaging. Procedures: We conducted two phase I trials for anti-epidermal growth factor receptor antibodies cetuximab-IRDye800CW (n=12) and panitumumab-IRDye800CW (n=15). Adults with biopsy-confirmed head and neck squamous cell carcinoma scheduled for standard-of-care surgery were eligible. For cetuximab-IRDye800CW, cohort 1 was intravenously infused with 2.5 mg/m2, cohort 2 received 25 mg/m2, and cohort 3 received 62.5 mg/m2. For panitumumab-IRDye800CW, cohorts received 0.06 mg/kg, 0.5 mg/kg, and 1 mg/kg, respectively. Electrocardiograms and blood samples were obtained, and patients were followed for 30 days post-study drug infusion. Results: Both fluorescently labeled antibodies had similar pharmacodynamic properties and minimal toxicities. Two infusion reactions occurred with cetuximab and none with panitumumab. There were no grade 2 or higher toxicities attributable to cetuximab-IRDye800CW or panitumumab-IRDye800CW; fifteen grade 1 adverse events occurred with cetuximab-IRDye800CW, and one grade 1 occurred with panitumumab-IRDye800CW. There were no significant differences in QTc prolongation between the two trials (p=0.8). Conclusions: Panitumumab-IRDye800CW and cetuximab-IRDye800CW have toxicity and pharmacodynamic profiles that match the parent compound, suggesting that other therapeutic antibodies may be repurposed as imaging agents with limited preclinical toxicology data. PMID:29721094

Anthropometrics and maturity status: A preliminary study of youth football head impact biomechanics.

PubMed

Yeargin, Susan W; Kingsley, Payton; Mensch, Jim M; Mihalik, Jason P; Monsma, Eva V

2017-10-03

There is a paucity of head impact biomechanics research focusing on youth athletes. Little is known about how youth subconcussive head impact tolerances are related to physical size and maturation. To examine the effects of age, anthropometric and maturational status variability on head impact biomechanics. Cross-sectional. Outdoor youth football facilities in South Carolina. Thirty-four male recreational youth football players, 8 to 13yrs. Categorized by CDC standards, independent variables were: age, height, mass, BMI, and estimated peak height velocity (PHV). Participants wore a designated head impact sensor (xPatch) on their mastoid process during practices and games. Linear acceleration (g) and rotational acceleration (rad/s 2 ). Boys in the older age category had a greater linear (F=17.72; P<0.001) and rotational acceleration (F=10.74; P<0.001) than those in the younger category. Post-PHV boys had higher linear (F=9.09, P=0.002) and rotational (F=5.57, P=0.018) accelerations than those who were pre-PHV. Rotational, but not linear acceleration differed by height category with lowest impacts found for the tallest category, whereas both linear and rotational accelerations by mass differences favored average and heavy categories. BMI overweight boys, had the greatest linear (F=5.25; P=0.011) and rotational acceleration (F=4.13; P=0.260) means. Post-PHV boys who were older, taller and had longer legs, but who were not heavier, had higher impacts perhaps due to the type of impacts sustained. Taller boys' heads are above their peers possibly encouraging hits in the torso region resulting in lower impact accelerations. Obese boys did not have sequential results compared to boys in the other BMI categories probably due to league rules, player position, and lack of momentum produced. Copyright © 2017 Elsevier B.V. All rights reserved.

Technology evaluation of man-rated acceleration test equipment for vestibular research

NASA Technical Reports Server (NTRS)

Taback, I.; Kenimer, R. L.; Butterfield, A. J.

1983-01-01

The considerations for eliminating acceleration noise cues in horizontal, linear, cyclic-motion sleds intended for both ground and shuttle-flight applications are addressed. the principal concerns are the acceleration transients associated with change in direction-of-motion for the carriage. The study presents a design limit for acceleration cues or transients based upon published measurements for thresholds of human perception to linear cyclic motion. The sources and levels for motion transients are presented based upon measurements obtained from existing sled systems. The approaches to a noise-free system recommends the use of air bearings for the carriage support and moving-coil linear induction motors operating at low frequency as the drive system. Metal belts running on air bearing pulleys provide an alternate approach to the driving system. The appendix presents a discussion of alternate testing techniques intended to provide preliminary type data by means of pendulums, linear motion devices and commercial air bearing tables.

Critical system issues and modeling requirements: The problem of beam energy sweep in an electron linear induction accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, W.C.; Barrett, D.M.; Sampayan, S.E.

1990-08-06

In this paper we discuss system issues and modeling requirements within the context of energy sweep in an electron linear induction accelerator. When needed, particular parameter values are taken from the ETA-II linear induction accelerator at Lawrence Livermore National Laboratory. For this paper, the most important parameter is energy sweep during a pulse. It is important to have low energy sweep to satisfy the FEL resonance condition and to limit the beam corkscrew motion. It is desired to achieve {Delta}E/E = {plus minus}1% for a 50-ns flattop whereas the present level of performance is {Delta}E/E = {plus minus}1% in 10more » ns. To improve this situation we will identify a number of areas in which modeling could help increase understanding and improve our ability to design linear induction accelerators.« less

Analysis of Monte Carlo accelerated iterative methods for sparse linear systems: Analysis of Monte Carlo accelerated iterative methods for sparse linear systems

DOE PAGES

Benzi, Michele; Evans, Thomas M.; Hamilton, Steven P.; ...

2017-03-05

Here, we consider hybrid deterministic-stochastic iterative algorithms for the solution of large, sparse linear systems. Starting from a convergent splitting of the coefficient matrix, we analyze various types of Monte Carlo acceleration schemes applied to the original preconditioned Richardson (stationary) iteration. We expect that these methods will have considerable potential for resiliency to faults when implemented on massively parallel machines. We also establish sufficient conditions for the convergence of the hybrid schemes, and we investigate different types of preconditioners including sparse approximate inverses. Numerical experiments on linear systems arising from the discretization of partial differential equations are presented.

Applications of the Strategic Defense Initiative's compact accelerators

NASA Technical Reports Server (NTRS)

Montanarelli, Nick; Lynch, Ted

1991-01-01

The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators. These accelerators, in turn, have produced spinoffs in several areas: the radio frequency quadrupole linear accelerator (RFQ linac) was recently incorporated into the design of a cancer therapy unit at the Loma Linda University Medical Center, an SDI-sponsored compact induction linear accelerator may replace Cobalt-60 radiation and hazardous ethylene-oxide as a method for sterilizing medical products, and other SDIO-funded accelerators may be used to produce the radioactive isotopes oxygen-15, nitrogen-13, carbon-11, and fluorine-18 for positron emission tomography (PET). Other applications of these accelerators include bomb detection, non-destructive inspection, decomposing toxic substances in contaminated ground water, and eliminating nuclear waste.

Two-dimensional spatiotemporal coding of linear acceleration in vestibular nuclei neurons

NASA Technical Reports Server (NTRS)

Angelaki, D. E.; Bush, G. A.; Perachio, A. A.

1993-01-01

Response properties of vertical (VC) and horizontal (HC) canal/otolith-convergent vestibular nuclei neurons were studied in decerebrate rats during stimulation with sinusoidal linear accelerations (0.2-1.4 Hz) along different directions in the head horizontal plane. A novel characteristic of the majority of tested neurons was the nonzero response often elicited during stimulation along the "null" direction (i.e., the direction perpendicular to the maximum sensitivity vector, Smax). The tuning ratio (Smin gain/Smax gain), a measure of the two-dimensional spatial sensitivity, depended on stimulus frequency. For most vestibular nuclei neurons, the tuning ratio was small at the lowest stimulus frequencies and progressively increased with frequency. Specifically, HC neurons were characterized by a flat Smax gain and an approximately 10-fold increase of Smin gain per frequency decade. Thus, these neurons encode linear acceleration when stimulated along their maximum sensitivity direction, and the rate of change of linear acceleration (jerk) when stimulated along their minimum sensitivity direction. While the Smax vectors were distributed throughout the horizontal plane, the Smin vectors were concentrated mainly ipsilaterally with respect to head acceleration and clustered around the naso-occipital head axis. The properties of VC neurons were distinctly different from those of HC cells. The majority of VC cells showed decreasing Smax gains and small, relatively flat, Smin gains as a function of frequency. The Smax vectors were distributed ipsilaterally relative to the induced (apparent) head tilt. In type I anterior or posterior VC neurons, Smax vectors were clustered around the projection of the respective ipsilateral canal plane onto the horizontal head plane. These distinct spatial and temporal properties of HC and VC neurons during linear acceleration are compatible with the spatiotemporal organization of the horizontal and the vertical/torsional ocular responses, respectively, elicited in the rat during linear translation in the horizontal head plane. In addition, the data suggest a spatially and temporally specific and selective otolith/canal convergence. We propose that the central otolith system is organized in canal coordinates such that there is a close alignment between the plane of angular acceleration (canal) sensitivity and the plane of linear acceleration (otolith) sensitivity in otolith/canal-convergent vestibular nuclei neurons.

Signature energetic analysis of accelerate electron beam after first acceleration station by accelerating stand of Joint Institute for Nuclear Research

NASA Astrophysics Data System (ADS)

Sledneva, A. S.; Kobets, V. V.

2017-06-01

The linear electron accelerator based on the LINAC - 800 accelerator imported from the Netherland is created at Joint Institute for Nuclear Research in the framework of the project on creation of the Testbed with an electron beam of a linear accelerator with an energy up to 250 MV. Currently two accelerator stations with a 60 MV energy of a beam are put in operation and the work is to put the beam through accelerating section of the third accelerator station. The electron beam with an energy of 23 MeV is used for testing the crystals (BaF2, CsI (native), and LYSO) in order to explore the opportunity to use them in particle detectors in experiments: Muon g-2, Mu2e, Comet, whose preparation requires a detailed study of the detectors properties such as their irradiation by the accelerator beams.

Self-shielded electron linear accelerators designed for radiation technologies

NASA Astrophysics Data System (ADS)

Belugin, V. M.; Rozanov, N. E.; Pirozhenko, V. M.

2009-09-01

This paper describes self-shielded high-intensity electron linear accelerators designed for radiation technologies. The specific property of the accelerators is that they do not apply an external magnetic field; acceleration and focusing of electron beams are performed by radio-frequency fields in the accelerating structures. The main characteristics of the accelerators are high current and beam power, but also reliable operation and a long service life. To obtain these characteristics, a number of problems have been solved, including a particular optimization of the accelerator components and the application of a variety of specific means. The paper describes features of the electron beam dynamics, accelerating structure, and radio-frequency power supply. Several compact self-shielded accelerators for radiation sterilization and x-ray cargo inspection have been created. The introduced methods made it possible to obtain a high intensity of the electron beam and good performance of the accelerators.

First Observations of Laser-Driven Acceleration of Relativistic Electrons in a Semi-Infinite Vacuum Space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plettner, T.; Byer, R.L.; Smith, T.I.

2006-02-17

We have observed acceleration of relativistic electrons in vacuum driven by a linearly polarized visible laser beam incident on a thin gold-coated reflective boundary. The observed energy modulation effect follows all the characteristics expected for linear acceleration caused by a longitudinal electric field. As predicted by the Lawson-Woodward theorem the laser driven modulation only appears in the presence of the boundary. It shows a linear dependence with the strength of the electric field of the laser beam and also it is critically dependent on the laser polarization. Finally, it appears to follow the expected angular dependence of the inverse transitionmore » radiation process. experiment as the Laser Electron Accelerator Project (LEAP).« less

Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry.

PubMed

Coroller, Thibaud P; Mak, Raymond H; Lewis, John H; Baldini, Elizabeth H; Chen, Aileen B; Colson, Yolonda L; Hacker, Fred L; Hermann, Gretchen; Kozono, David; Mannarino, Edward; Molodowitch, Christina; Wee, Jon O; Sher, David J; Killoran, Joseph H

2014-01-01

To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) for patients receiving lung stereotactic body radiotherapy (SBRT) using treatment planning methods to minimize CW dose and a risk-adapted fractionation scheme. We reviewed data from 72 treatment plans, from 69 lung SBRT patients with at least one year of follow-up or CW toxicity, who were treated at our center between 2010 and 2013. Treatment plans were optimized to reduce CW dose and patients received a risk-adapted fractionation of 18 Gy×3 fractions (54 Gy total) if the CW V30 was less than 30 mL or 10-12 Gy×5 fractions (50-60 Gy total) otherwise. The association between CW toxicity and patient characteristics, treatment parameters and dose metrics, including biologically equivalent dose, were analyzed using logistic regression. With a median follow-up of 20 months, 6 (8.3%) patients developed CW pain including three (4.2%) grade 1, two (2.8%) grade 2 and one (1.4%) grade 3. Five (6.9%) patients developed rib fractures, one of which was symptomatic. No significant associations between CW toxicity and patient and dosimetric variables were identified on univariate nor multivariate analysis. Optimization of treatment plans to reduce CW dose and a risk-adapted fractionation strategy of three or five fractions based on the CW V30 resulted in a low incidence of CW toxicity. Under these conditions, none of the patient characteristics or dose metrics we examined appeared to be predictive of CW pain.

Short-Term and Working Memory Skills in Primary School-Aged Children with Specific Language Impairment and Children with Pragmatic Language Impairment: Phonological, Linguistic and Visuo-Spatial Aspects

ERIC Educational Resources Information Center

Freed, Jenny; Lockton, Elaine; Adams, Catherine

2012-01-01

Background: Children with specific language impairment (CwSLI) are consistently reported to have short-term memory (STM) and working memory (WM) difficulties. Aim: To compare STM and WM abilities in CwSLI with children with pragmatic language impairment (CwPLI). Methods & Procedures: Primary school-aged CwSLI (n = 12) and CwPLI (n = 23) were…

Inviscid linear stability analysis of two vertical columns of different densities in a gravitational acceleration field

DOE PAGES

Prathama, Aditya Heru; Pantano, Carlos

2017-08-09

Here, we study the inviscid linear stability of a vertical interface separating two fluids of different densities and subject to a gravitational acceleration field parallel to the interface. In this arrangement, the two free streams are constantly accelerated, which means that the linear stability analysis is not amenable to Fourier or Laplace solution in time. Instead, we derive the equations analytically by the initial-value problem method and express the solution in terms of the well-known parabolic cylinder function. The results, which can be classified as an accelerating Kelvin–Helmholtz configuration, show that even in the presence of surface tension, the interfacemore » is unconditionally unstable at all wavemodes. This is a consequence of the ever increasing momentum of the free streams, as gravity accelerates them indefinitely. The instability can be shown to grow as the exponential of a quadratic function of time.« less

Enhanced accuracy of the microwave field strength measurement in a CW-EPR by pulsed modulation technique

NASA Astrophysics Data System (ADS)

Rakvin, B.; Carić, D.; Kveder, M.

2018-02-01

The microwave magnetic field strength, B1, in the cavity of a conventional continuous wave electron paramagnetic resonance, CW-EPR, spectrometer was measured by employing modulation sidebands, MS, in the EPR spectrum. MS spectrum in CW-EPR is produced by applying the modulation frequency, ωrf, which exceeds the linewidth, δB, given in frequency units. An amplitude-modulated CW-EPR, AM-CW-EPR, was selected as detection method. Theoretical description of AM-CW-EPR spectrum was modified by adding Bloch-Siegert-like shift obtained by taking into account the cumulative effect of the non-resonant interactions between the driving fields and the spin system. This approach enables to enhance the precision of B1 measurement. In order to increase the sensitivity of the method when saturation effects, due to higher intensity of B1, decrease the resolution of AM-CW-EPR spectrum, detection at the second harmonic of CW-EPR has been employed.

Enhanced accuracy of the microwave field strength measurement in a CW-EPR by pulsed modulation technique.

PubMed

Rakvin, B; Carić, D; Kveder, M

2018-02-01

The microwave magnetic field strength, B 1 , in the cavity of a conventional continuous wave electron paramagnetic resonance, CW-EPR, spectrometer was measured by employing modulation sidebands, MS, in the EPR spectrum. MS spectrum in CW-EPR is produced by applying the modulation frequency, ω rf , which exceeds the linewidth, δB, given in frequency units. An amplitude-modulated CW-EPR, AM-CW-EPR, was selected as detection method. Theoretical description of AM-CW-EPR spectrum was modified by adding Bloch-Siegert-like shift obtained by taking into account the cumulative effect of the non-resonant interactions between the driving fields and the spin system. This approach enables to enhance the precision of B 1 measurement. In order to increase the sensitivity of the method when saturation effects, due to higher intensity of B 1 , decrease the resolution of AM-CW-EPR spectrum, detection at the second harmonic of CW-EPR has been employed. Copyright © 2018 Elsevier Inc. All rights reserved.

International Workshop on Linear Colliders 2010

ScienceCinema

Lebrun, Ph.

2018-06-20

IWLC2010 International Workshop on Linear Colliders 2010ECFA-CLIC-ILC joint meeting: Monday 18 October - Friday 22 October 2010Venue: CERN and CICG (International Conference Centre Geneva, Switzerland). This year, the International Workshop on Linear Colliders organized by the European Committee for Future Accelerators (ECFA) will study the physics, detectors and accelerator complex of a linear collider covering both CLIC and ILC options. Contact Workshop Secretariat  IWLC2010 is hosted by CERN.

International Workshop on Linear Colliders 2010

ScienceCinema

Yamada, Sakue

2018-05-24

IWLC2010 International Workshop on Linear Colliders 2010ECFA-CLIC-ILC joint meeting: Monday 18 October - Friday 22 October 2010Venue: CERN and CICG (International Conference Centre Geneva, Switzerland) This year, the International Workshop on Linear Colliders organized by the European Committee for Future Accelerators (ECFA) will study the physics, detectors and accelerator complex of a linear collider covering both CLIC and ILC options. Contact Workshop Secretariat  IWLC2010 is hosted by CERN

Source apportionment modeling of volatile organic compounds in streams

USGS Publications Warehouse

Pankow, J.F.; Asher, W.E.; Zogorski, J.S.

2006-01-01

It often is of interest to understand the relative importance of the different sources contributing to the concentration cw of a contaminant in a stream; the portions related to sources 1, 2, 3, etc. are denoted cw,1, cw,2, cw,3, etc. Like c w, 'he fractions ??1, = cw,1/c w, ??2 = cw,2/cw, ??3 = cw,3/cw, etc. depend on location and time. Volatile organic compounds (VOCs) can undergo absorption from the atmosphere into stream water or loss from stream water to the atmosphere, causing complexities affecting the source apportionment (SA) of VOCs in streams. Two SA rules are elaborated. Rule 1: VOC entering a stream across the air/water interface exclusively is assigned to the atmospheric portion of cw. Rule 2: VOC loss by volatilization, flow loss to groundwater, in-stream degradation, etc. is distributed over cw,1 cw,2, c w,3, etc. in proportion to their corresponding ?? values. How the two SA rules are applied, as well as the nature of the SA output for a given case, will depend on whether transport across the air/water interface is handled using the net flux F convention or using the individual fluxes J convention. Four hypothetical stream cases involving acetone, methyl-tert-butyl ether (MTBE), benzene, chloroform, and perchloroethylene (PCE) are considered. Acetone and MTBE are sufficiently water soluble from air for a domestic atmospheric source to be capable of yielding cw values approaching the common water quality guideline range of 1 to 10 ??g/L. For most other VOCs, such levels cause net outgassing (F > 0). When F > 0 in a given section of stream, in the net flux convention, all of the ??j, for the compound remain unchanged over that section while cw decreases. A characteristic time ??d can be calculated to predict when there will be differences between SA results obtained by the net flux convention versus the individual fluxes convention. Source apportionment modeling provides the framework necessary for comparing different strategies for mitigating contamination at points of interest along a stream. ?? 2006 SETAC.

Adaptation to vestibular disorientation. IX, Influence of head position on the habituation of vertical nystagmus.

DOT National Transportation Integrated Search

1968-03-01

Interactions of linear and angular accelerations are frequently experienced by pilots during aircraft maneuvers. Several recent studies have indicated that the otoliths (detectors of linear acceleration) may influence responses of the semicircular ca...

Conduction cooling systems for linear accelerator cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kephart, Robert

A conduction cooling system for linear accelerator cavities. The system conducts heat from the cavities to a refrigeration unit using at least one cavity cooler interconnected with a cooling connector. The cavity cooler and cooling connector are both made from solid material having a very high thermal conductivity of approximately 1.times.10.sup.4 W m.sup.-1 K.sup.-1 at temperatures of approximately 4 degrees K. This allows for very simple and effective conduction of waste heat from the linear accelerator cavities to the cavity cooler, along the cooling connector, and thence to the refrigeration unit.

Assessment of human exposure doses received by activation of medical linear accelerator components

NASA Astrophysics Data System (ADS)

Lee, D.-Y.; Kim, J.-H.; Park, E.-T.

2017-08-01

This study analyzes the radiation exposure dose that an operator can receive from radioactive components during maintenance or repair of a linear accelerator. This study further aims to evaluate radiological safety. Simulations are performed on 10 MV and 15 MV photon beams, which are the most frequently used high-energy beams in clinics. The simulation analyzes components in order of activity and the human exposure dose based on the amount of neutrons received. As a result, the neutron dose, radiation dose, and human exposure dose are ranked in order of target, primary collimator, flattening filter, multi-leaf collimator, and secondary collimator, where the minimum dose is 9.34E-07 mSv/h and the maximum is 1.71E-02 mSv/h. When applying the general dose limit (radiation worker 20 mSv/year, pubic 1 mSv/year) in accordance with the Nuclear Safety Act, all components of a linear accelerator are evaluated as below the threshold value. Therefore, the results suggest that there is no serious safety issue for operators in maintaining and repairing a linear accelerator. Nevertheless, if an operator recognizes an exposure from the components of a linear accelerator during operation and considers the operating time and shielding against external exposure, exposure of the operator is expected to be minimized.

Third party EPID with IGRT capability retrofitted onto an existing medical linear accelerator

PubMed Central

Odero, DO; Shimm, DS

2009-01-01

Radiation therapy requires precision to avoid unintended irradiation of normal organs. Electronic Portal Imaging Devices (EPIDs), can help with precise patient positioning for accurate treatment. EPIDs are now bundled with new linear accelerators, or they can be purchased from the Linac manufacturer for retrofit. Retrofitting a third party EPID to a linear accelerator can pose challenges. The authors describe a relatively inexpensive third party CCD camera-based EPID manufactured by TheraView (Cablon Medical B.V.), installed onto a Siemens Primus linear accelerator, and integrated with a Lantis record and verify system, an Oldelft simulator with Digital Therapy Imaging (DTI) unit, and a Philips ADAC Pinnacle treatment planning system (TPS). This system integrates well with existing equipment and its software can process DICOM images from other sources. The system provides a complete imaging system that eliminates the need for separate software for portal image viewing, interpretation, analysis, archiving, image guided radiation therapy and other image management applications. It can also be accessed remotely via safe VPN tunnels. TheraView EPID retrofit therefore presents an example of a less expensive alternative to linear accelerator manufacturers’ proprietary EPIDs suitable for implementation in third world countries radiation therapy departments which are often faced with limited financial resources. PMID:21611056

Third party EPID with IGRT capability retrofitted onto an existing medical linear accelerator.

PubMed

Odero, D O; Shimm, D S

2009-07-01

Radiation therapy requires precision to avoid unintended irradiation of normal organs. Electronic Portal Imaging Devices (EPIDs), can help with precise patient positioning for accurate treatment. EPIDs are now bundled with new linear accelerators, or they can be purchased from the Linac manufacturer for retrofit. Retrofitting a third party EPID to a linear accelerator can pose challenges. The authors describe a relatively inexpensive third party CCD camera-based EPID manufactured by TheraView (Cablon Medical B.V.), installed onto a Siemens Primus linear accelerator, and integrated with a Lantis record and verify system, an Oldelft simulator with Digital Therapy Imaging (DTI) unit, and a Philips ADAC Pinnacle treatment planning system (TPS). This system integrates well with existing equipment and its software can process DICOM images from other sources. The system provides a complete imaging system that eliminates the need for separate software for portal image viewing, interpretation, analysis, archiving, image guided radiation therapy and other image management applications. It can also be accessed remotely via safe VPN tunnels. TheraView EPID retrofit therefore presents an example of a less expensive alternative to linear accelerator manufacturers' proprietary EPIDs suitable for implementation in third world countries radiation therapy departments which are often faced with limited financial resources.

Detection of undistorted continuous wave (CW) electron paramagnetic resonance (EPR) spectra with non-adiabatic rapid sweep (NARS) of the magnetic field

PubMed Central

Kittell, Aaron W.; Camenisch, Theodore G.; Ratke, Joseph J.; Sidabras, Jason W.; Hyde, James S.

2011-01-01

A continuous wave (CW) electron paramagnetic resonance (EPR) spectrum is typically displayed as the first harmonic response to the application of 100 kHz magnetic field modulation, which is used to enhance sensitivity by reducing the level of 1/f noise. However, magnetic field modulation of any amplitude causes spectral broadening and sacrifices EPR spectral intensity by at least a factor of two. In the work presented here, a CW rapid-scan spectroscopic technique that avoids these compromises and also provides a means of avoiding 1/f noise is developed. This technique, termed non-adiabatic rapid sweep (NARS) EPR, consists of repetitively sweeping the polarizing magnetic field in a linear manner over a spectral fragment with a small coil at a repetition rate that is sufficiently high that receiver noise, microwave phase noise, and environmental microphonics, each of which has 1/f characteristics, are overcome. Nevertheless, the rate of sweep is sufficiently slow that adiabatic responses are avoided and the spin system is always close to thermal equilibrium. The repetitively acquired spectra from the spectral fragment are averaged. Under these conditions, undistorted pure absorption spectra are obtained without broadening or loss of signal intensity. A digital filter such as a moving average is applied to remove high frequency noise, which is approximately equivalent in bandwidth to use of an integrating time constant in conventional field modulation with lock-in detection. Nitroxide spectra at L- and X-band are presented. PMID:21741868

Continuous-wave and quasi-continuous wave thulium-doped all-fiber laser: implementation on kidney stone fragmentations.

PubMed

Pal, Debasis; Ghosh, Aditi; Sen, Ranjan; Pal, Atasi

2016-08-10

A continuous-wave (CW) as well as quasi-continuous wave (QCW) thulium-doped all-fiber laser at 1.94 μm has been designed for targeting applications in urology. The thulium-doped active fiber with an octagonal-shaped inner cladding is pumped at 793 nm to achieve stable CW laser power of 10 W with 32% lasing efficiency (against launched pump power). The linear variation of laser power with pump offers a scope of further power scaling. A QCW operation with variation of duty cycle from 0.5% to 90%, repetition rate from 0.1 Hz to 1 kHz, and pulse width from 40 μs to 2 s has been presented. Laser power of 9.5 W in CW mode of operation and average power of 5.2 W with energy range of 10.4-104 mJ in QCW mode of operation has been employed to fragment calcium oxalate monohydrate kidney stones (size of 1.5-4 cm) having different colors and composition. Dependence of ablation threshold, ablation rate, and average fragmented particle size on the average power and energy has been studied. One minute of laser exposure results in fragmentation of a stone surface with ablation rate of 8  mg/min having minimum particle size of 6.54 μm with an average size of 20-100 μm ensuring the natural removal of fragmented parts through the urethra.

A 20fs synchronization system for lasers and cavities in accelerators and FELs

NASA Astrophysics Data System (ADS)

Wilcox, R. B.; Byrd, J. M.; Doolittle, L. R.; Huang, G.; Staples, J. W.

2010-02-01

A fiber-optic RF distribution system has been developed for synchronizing lasers and RF plants in short pulse FELs. Typical requirements are 50-100fs rms over time periods from 1ms to several hours. Our system amplitude modulates a CW laser signal, senses fiber length using an interferometer, and feed-forward corrects the RF phase digitally at the receiver. We demonstrate less than 15fs rms error over 12 hours, between two independent channels with a fiber path length difference of 200m and transmitting S-band RF. The system is constructed using standard telecommunications components, and uses regular telecom fiber.

Permanent magnet focused X-band photoinjector

DOEpatents

Yu, David U. L.; Rosenzweig, James

2002-09-10

A compact high energy photoelectron injector integrates the photocathode directly into a multicell linear accelerator with no drift space between the injection and the linac. High electron beam brightness is achieved by accelerating a tightly focused electron beam in an integrated, multi-cell, X-band rf linear accelerator (linac). The photoelectron linac employs a Plane-Wave-Transformer (PWT) design which provides strong cell-to-cell coupling, easing manufacturing tolerances and costs.

Staging optics considerations for a plasma wakefield acceleration linear collider

NASA Astrophysics Data System (ADS)

Lindstrøm, C. A.; Adli, E.; Allen, J. M.; Delahaye, J. P.; Hogan, M. J.; Joshi, C.; Muggli, P.; Raubenheimer, T. O.; Yakimenko, V.

2016-09-01

Plasma wakefield acceleration offers acceleration gradients of several GeV/m, ideal for a next-generation linear collider. The beam optics requirements between plasma cells include injection and extraction of drive beams, matching the main beam beta functions into the next cell, canceling dispersion as well as constraining bunch lengthening and chromaticity. To maintain a high effective acceleration gradient, this must be accomplished in the shortest distance possible. A working example is presented, using novel methods to correct chromaticity, as well as scaling laws for a high energy regime.

HEAVY ION LINEAR ACCELERATOR

DOEpatents

Van Atta, C.M.; Beringer, R.; Smith, L.

1959-01-01

A linear accelerator of heavy ions is described. The basic contributions of the invention consist of a method and apparatus for obtaining high energy particles of an element with an increased charge-to-mass ratio. The method comprises the steps of ionizing the atoms of an element, accelerating the resultant ions to an energy substantially equal to one Mev per nucleon, stripping orbital electrons from the accelerated ions by passing the ions through a curtain of elemental vapor disposed transversely of the path of the ions to provide a second charge-to-mass ratio, and finally accelerating the resultant stripped ions to a final energy of at least ten Mev per nucleon.

Angular Impact Mitigation System for Bicycle Helmets to Reduce Head Acceleration and Risk of Traumatic Brain Injury

PubMed Central

Hansen, Kirk; Dau, Nathan; Feist, Florian; Deck, Caroline; Willinger, Rémy; Madey, Steven M.; Bottlang, Michael

2013-01-01

Angular acceleration of the head is a known cause of traumatic brain injury (TBI), but contemporary bicycle helmets lack dedicated mechanisms to mitigate angular acceleration. A novel Angular Impact Mitigation (AIM) system for bicycle helmets has been developed that employs an elastically suspended aluminum honeycomb liner to absorb linear acceleration in normal impacts as well as angular acceleration in oblique impacts. This study tested bicycle helmets with and without AIM technology to comparatively assess impact mitigation. Normal impact tests were performed to measure linear head acceleration. Oblique impact tests were performed to measure angular head acceleration and neck loading. Furthermore, acceleration histories of oblique impacts were analyzed in a computational head model to predict the resulting risk of TBI in the form of concussion and diffuse axonal injury (DAI). Compared to standard helmets, AIM helmets resulted in a 14% reduction in peak linear acceleration (p < 0.001), a 34% reduction in peak angular acceleration (p < 0.001), and a 22% to 32% reduction in neck loading (p < 0.001). Computational results predicted that AIM helmets reduced the risk of concussion and DAI by 27% and 44%, respectively. In conclusion, these results demonstrated that AIM technology could effectively improve impact mitigation compared to a contemporary expanded polystyrene-based bicycle helmet, and may enhance prevention of bicycle-related TBI. Further research is required. PMID:23770518

The detrimental effect of friction on space microgravity robotics

NASA Technical Reports Server (NTRS)

Newman, Wyatt S.; Glosser, Gregory D.; Miller, Jeffrey H.; Rohn, Douglas

1992-01-01

The authors present an analysis of why control systems are ineffective in compensating for acceleration disturbances due to Coulomb friction. Linear arguments indicate that the effects of Coulomb friction on a body are most difficult to reject when the control actuator is separated from the body of compliance. The linear arguments were illustrated in a nonlinear simulation of optimal linear tracking control in the presence of nonlinear friction. The results of endpoint acceleration measurements for four robot designs are presented and are compared with simulation and to equivalent measurements on a human. It is concluded that Coulomb friction in common bearings and transmission induces unacceptable levels of endpoint acceleration, that these accelerations cannot be adequately attenuated by control, and that robots for microgravity work will require special design considerations for inherently low friction.

Industrialization of the nitrogen-doping preparation for SRF cavities for LCLS-II

DOE PAGES

Gonnella, D.; Aderhold, S.; Burrill, A.; ...

2017-12-02

The Linac Coherent Light Source II (LCLS-II) is a new state-of-the-art coherent X-ray source being constructed at SLAC National Accelerator Laboratory. It employs 280 superconducting radio frequency (SRF) cavities in order operate in continuous wave (CW) mode. To reduce the overall cryogenic cost of such a large accelerator, nitrogen-doping of the SRF cavities is being used. Nitrogen-doping has consistently been shown to increase the efficiency of SRF cavities operating in the 2.0 K regime and at medium fields (15–20 MV/m) in vertical cavity tests and horizontal cryomodule tests. While nitrogen-doping’s efficacy for improvement of cavity performance was demonstrated at threemore » independent labs, Fermilab, Jefferson Lab, and Cornell University, transfer of the technology to industry for LCLS-II production was not without challenges. Here in this paper, we present results from the beginning of LCLS-II cavity production. We discuss qualification of the cavity vendors and the first cavities from each vendor. Finally, we demonstrate that nitrogen-doping has been successfully transferred to SRF cavity vendors, resulting in consistent production of cavities with better cryogenic efficiency than has ever been achieved for a large-scale accelerator.« less

Industrialization of the nitrogen-doping preparation for SRF cavities for LCLS-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonnella, D.; Aderhold, S.; Burrill, A.

The Linac Coherent Light Source II (LCLS-II) is a new state-of-the-art coherent X-ray source being constructed at SLAC National Accelerator Laboratory. It employs 280 superconducting radio frequency (SRF) cavities in order operate in continuous wave (CW) mode. To reduce the overall cryogenic cost of such a large accelerator, nitrogen-doping of the SRF cavities is being used. Nitrogen-doping has consistently been shown to increase the efficiency of SRF cavities operating in the 2.0 K regime and at medium fields (15–20 MV/m) in vertical cavity tests and horizontal cryomodule tests. While nitrogen-doping’s efficacy for improvement of cavity performance was demonstrated at threemore » independent labs, Fermilab, Jefferson Lab, and Cornell University, transfer of the technology to industry for LCLS-II production was not without challenges. Here in this paper, we present results from the beginning of LCLS-II cavity production. We discuss qualification of the cavity vendors and the first cavities from each vendor. Finally, we demonstrate that nitrogen-doping has been successfully transferred to SRF cavity vendors, resulting in consistent production of cavities with better cryogenic efficiency than has ever been achieved for a large-scale accelerator.« less

Industrialization of the nitrogen-doping preparation for SRF cavities for LCLS-II

NASA Astrophysics Data System (ADS)

Gonnella, D.; Aderhold, S.; Burrill, A.; Daly, E.; Davis, K.; Grassellino, A.; Grimm, C.; Khabiboulline, T.; Marhauser, F.; Melnychuk, O.; Palczewski, A.; Posen, S.; Ross, M.; Sergatskov, D.; Sukhanov, A.; Trenikhina, Y.; Wilson, K. M.

2018-03-01

The Linac Coherent Light Source II (LCLS-II) is a new state-of-the-art coherent X-ray source being constructed at SLAC National Accelerator Laboratory. It employs 280 superconducting radio frequency (SRF) cavities in order operate in continuous wave (CW) mode. To reduce the overall cryogenic cost of such a large accelerator, nitrogen-doping of the SRF cavities is being used. Nitrogen-doping has consistently been shown to increase the efficiency of SRF cavities operating in the 2.0 K regime and at medium fields (15-20 MV/m) in vertical cavity tests and horizontal cryomodule tests. While nitrogen-doping's efficacy for improvement of cavity performance was demonstrated at three independent labs, Fermilab, Jefferson Lab, and Cornell University, transfer of the technology to industry for LCLS-II production was not without challenges. Here we present results from the beginning of LCLS-II cavity production. We discuss qualification of the cavity vendors and the first cavities from each vendor. Finally, we demonstrate that nitrogen-doping has been successfully transferred to SRF cavity vendors, resulting in consistent production of cavities with better cryogenic efficiency than has ever been achieved for a large-scale accelerator.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonnella, D.; Aderhold, S.; Burrill, A.

The Linac Coherent Light Source II (LCLS-II) is a new state-of-the-art coherent X-ray source being constructed at SLAC National Accelerator Laboratory. It employs 280 superconducting radio frequency (SRF) cavities in order operate in continuous wave (CW) mode. To reduce the overall cryogenic cost of such a large accelerator, nitrogen-doping of the SRF cavities is being used. Nitrogen-doping has consistently been shown to increase the efficiency of SRF cavities operating in the 2.0 K regime and at medium fields (15–20 MV/m) in vertical cavity tests and horizontal cryomodule tests. While nitrogen-doping’s efficacy for improvement of cavity performance was demonstrated at threemore » independent labs, Fermilab, Jefferson Lab, and Cornell University, transfer of the technology to industry for LCLS-II production was not without challenges. Here in this paper, we present results from the beginning of LCLS-II cavity production. We discuss qualification of the cavity vendors and the first cavities from each vendor. Finally, we demonstrate that nitrogen-doping has been successfully transferred to SRF cavity vendors, resulting in consistent production of cavities with better cryogenic efficiency than has ever been achieved for a large-scale accelerator.« less

Sequence and structural characterization of great salt lake bacteriophage CW02, a member of the T7-like supergroup.

PubMed

Shen, Peter S; Domek, Matthew J; Sanz-García, Eduardo; Makaju, Aman; Taylor, Ryan M; Hoggan, Ryan; Culumber, Michele D; Oberg, Craig J; Breakwell, Donald P; Prince, John T; Belnap, David M

2012-08-01

Halophage CW02 infects a Salinivibrio costicola-like bacterium, SA50, isolated from the Great Salt Lake. Following isolation, cultivation, and purification, CW02 was characterized by DNA sequencing, mass spectrometry, and electron microscopy. A conserved module of structural genes places CW02 in the T7 supergroup, members of which are found in diverse aquatic environments, including marine and freshwater ecosystems. CW02 has morphological similarities to viruses of the Podoviridae family. The structure of CW02, solved by cryogenic electron microscopy and three-dimensional reconstruction, enabled the fitting of a portion of the bacteriophage HK97 capsid protein into CW02 capsid density, thereby providing additional evidence that capsid proteins of tailed double-stranded DNA phages have a conserved fold. The CW02 capsid consists of bacteriophage lambda gpD-like densities that likely contribute to particle stability. Turret-like densities were found on icosahedral vertices and may represent a unique adaptation similar to what has been seen in other extremophilic viruses that infect archaea, such as Sulfolobus turreted icosahedral virus and halophage SH1.

Capillary waves and the decay of density correlations at liquid surfaces

NASA Astrophysics Data System (ADS)

Hernández-Muñoz, Jose; Chacón, Enrique; Tarazona, Pedro

2016-12-01

Wertheim predicted strong density-density correlations at free liquid surfaces, produced by capillary wave fluctuations of the interface [M. S. Wertheim, J. Chem. Phys. 65, 2377 (1976), 10.1063/1.433352]. That prediction has been used to search for a link between capillary wave (CW) theory and density functional (DF) formalism for classical fluids. In particular, Parry et al. have recently analyzed the decaying tails of these CW effects moving away from the interface as a clue for the extended CW theory [A. O. Parry et al., J. Phys.: Condens. Matter 28, 244013 (2016), 10.1088/0953-8984/28/24/244013], beyond the strict long-wavelength limit studied by Wertheim. Some apparently fundamental inconsistencies between the CW and the DF theoretical views of the fluid interfaces arose from the asymptotic analysis of the CW signal. In this paper we revisit the problem of the CW asymptotic decay with a separation of local non-CW surface correlation effects from those that are a truly nonlocal propagation of the CW fluctuations from the surface towards the liquid bulk.

Performance assessment of aeration and radial oxygen loss assisted cathode based integrated constructed wetland-microbial fuel cell systems.

PubMed

Srivastava, Pratiksha; Dwivedi, Saurabh; Kumar, Naresh; Abbassi, Rouzbeh; Garaniya, Vikram; Yadav, Asheesh Kumar

2017-11-01

The present study explores low-cost cathode development possibility using radial oxygen loss (ROL) of Canna indica plants and intermittent aeration (IA) for wastewater treatment and electricity generation in constructed wetland-microbial fuel cell (CW-MFC) system. Two CW-MFC microcosms were developed. Amongst them, one microcosm was planted with Canna indica plants for evaluating the ROL dependent cathode reaction (CW-MFC dependent on ROL) and another microcosm was equipped with intermittent aeration for evaluating the intermittent aeration dependent cathode reaction (CW-MFC with additional IA). The CW-MFC with additional IA has achieved 78.71% and 53.23%, and CW-MFC dependent on ROL has achieved 72.17% and 46.77% COD removal from synthetic wastewater containing glucose loads of 0.7gL -1 and 2.0gL -1 , respectively. The maximum power density of 31.04mWm -3 and 19.60mWm -3 was achieved in CW-MFC with additional IA and CW-MFC dependent on ROL, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

Comparison of isolate dadih with yeast dadih in improving nutrition quality of Cassava Waste (CW)

NASA Astrophysics Data System (ADS)

Ginting, N.

2018-03-01

The cassava industry in North Sumatra Province was one of the most significant agricultural industries. Waste from the cassava industry which was called cassava waste/CW/Onggok was used as feed for ruminants such as cattle, sheep and monogastric such as pigs. The low nutrients in CW caused the need to find a way for improving the nutrients quality. This research was conducted with the aim to help livestockers to ferment their livestock feed. This study compared the ability of fermentation between dadih isolate with dadih yeast. Dadih is traditional food in Indonesia where milk is fermented in bamboo tube. Dadih yeast was made by mixing dadih and whey with flour, made in around shape and sun dried. The results showed that pH of CW by dadih isolate was the lowest while crude protein, crude fiber and fat in CW treated with dadih isolate were improved significantly compared either to control or to dadih starter while fermented CW was better than non-fermented CW. It was recommended livestockers to ferment CW by using either by dadih isolate or dadih starter.

Development of a dual-pulse RF driver for an S-band (= 2856 MHz) RF electron linear accelerator

NASA Astrophysics Data System (ADS)

Cha, Sungsu; Kim, Yujong; Lee, Byeong-No; Lee, Byung Cheol; Cha, Hyungki; Ha, Jang Ho; Park, Hyung Dal; Lee, Seung Hyun; Kim, Hui Su; Buaphad, Pikad

2016-04-01

The radiation equipment research division of Korea Atomic Energy Research Institute has developed a Container Inspection System (CIS) using a Radio Frequency (RF) electron linear accelerator for port security. The primary purpose of the CIS is to detect nuclear materials and explosives, as well country-specific prohibited substances, e.g., smuggled. The CIS consists of a 9/6 MeV dualenergy electron linear accelerator for distinguishing between organic and inorganic materials. The accelerator consists of an electron gun, an RF accelerating structure, an RF driver, a modulator, electromagnets, a cooling system, a X-ray generating target, X-ray collimator, a detector, and a container moving system. The RF driver is an important part of the configuration because it is the RF power source: it supplies the RF power to the accelerating structure. A unique aspect of the RF driver is that it generates dual RF power to generate dual energy (9/6 MeV). The advantage of this RF driver is that it can allow the pulse width to vary and can be used to obtain a wide range of energy output, and pulse repetition rates up to 300 Hz. For this reason, 140 W (5 MW - 9 MeV) and 37 W (3.4 MW - 6 MeV) power outputs are available independently. A high power test for 20 minutes demonstrate that stable dual output powers can be generated. Moreover, the dual power can be applied to the accelerator which has stable accelerator operation. In this paper, the design, fabrication and high power test of the RF driver for the RF electron linear accelerator (linac) are presented.

Study of quality assurance regulations for linear accelerators in Korea: A comparison study between the current status in Korea and the international guidelines

NASA Astrophysics Data System (ADS)

Lee, Hyunho; Jeong, Seonghoon; Jo, Yunhui; Yoon, Myonggeun

2015-07-01

Quality assurance (QA) for medical linear accelerators is indispensable for appropriate cancer treatment. Some international organizations and advanced Western countries have provided QA guidelines for linear accelerators. Currently, QA regulations for linear accelerators in Korean hospitals specify a system in which each hospital stipulates its independent hospital-based protocols for QA procedures (HP_QAPs) and conducts QA based on those HP_QAPs while regulatory authorities verify whether items under those HP_QAPs have been performed. However, because this regulatory method cannot guarantee the quality of universal treatment and QA items with tolerance criteria are different in many hospitals, the presentation of standardized QA items and tolerance criteria is essential. In this study, QA items in HP_QAPs from various hospitals and those presented by international organizations, such as the International Atomic Energy Agency, the European Union, and the American Association of Physicist in Medicine, and by advanced Western countries, such as the USA, the UK, and Canada, were compared. Concordance rates between QA items for linear accelerators that were presented by the aforementioned organizations and those currently being implemented in Korean hospitals were shown to exhibit a daily QA of 50%, a weekly QA of 22%, a monthly QA of 43%, and an annual QA of 65%, and the overall concordance rates of all QA items were approximately 48%. In the comparison between QA items being implemented in Korean hospitals and those being implemented in advanced Western countries, concordance rates were shown to exhibit a daily QA of 50%, a weekly QA of 33%, a monthly QA of 60%, and an annual QA of 67%, and the overall concordance rates of all QA items were approximately 57%. The results of this study indicate that the HP_QAPs currently implemented by Korean hospitals as QA standards for linear accelerators used in radiation therapy do not meet international standards. If this problem is to be solved, national standardized QA items and procedures for linear accelerators need to be developed.

Storm event-scale nutrient attenuation in constructed wetlands experiencing a Mediterranean climate: A comparison of a surface flow and hybrid surface-subsurface flow system.

PubMed

Adyel, Tanveer M; Oldham, Carolyn E; Hipsey, Matthew R

2017-11-15

Among different Water Sensitive Urban Design options, constructed wetlands (CWs) are used to protect and restore downstream water quality by attenuating nutrients generated by stormwater runoff. This research compared the nutrient attenuation ability during a diverse population of storm events of two CWs: (a) a hybrid CW with multiple alternating surface flow (SF) and laterite-based subsurface flow (SSF) compartments, and (b) a single stage SF CW. Within-storm variability, nutrient concentrations were assessed at 2 to 3-h intervals at both the main inlet and outlet of each CW. Dissolved oxygen concentrations of the surface waters were also monitored at 10-min intervals using high frequency in situ sensors. Nutrient loads into the CWs were observed to be higher when a high rainfall event occurred, particularly after longer antecedent dry conditions. Longer hydraulic retention times promoted higher attenuation at both sites. However, the relative extent of nutrient attenuation differed between the CW types; the mean total nitrogen (TN) attenuation in the hybrid and SF CW was 45 and 48%, respectively. The hybrid CW attenuated 67% total phosphorus (TP) loads on average, while the SF CW acted as a net TP source. Periodic storm events transitioned the lentic CW into a lotic CW and caused riparian zone saturation; it was therefore hypothesized that such saturation of organic matter rich-riparian zones led to release of TP in the system. The hybrid CW attenuated the released TP in the downstream laterite-based SSF compartments. Diel oxygen metabolism calculated before and after the storm events was found to be strongly correlated with water temperature, solar exposure and antecedent dry condition during the pre-storm conditions. Furthermore, the SF CW showed a significant relationship between overall nutrient load attenuation and the change in oxygen metabolism during the storm perturbation, suggesting oxygen variation could be a useful proxy indicator of CW function. Copyright © 2017 Elsevier B.V. All rights reserved.

Combined effects of HLA-Cw6, body mass index and waist-hip ratio on psoriasis vulgaris in Chinese Han population.

PubMed

Jin, Yongtang; Zhang, Fengyu; Yang, Sen; Kong, Yunming; Xiao, Fengli; Hou, Yong; Fan, Xing; Zhang, Xuejun

2008-11-01

Psoriasis is a chronic inflammatory skin disease associated with an HLA-Cw6 allele. Higher waist-hip ratio (WHR) and body mass index (BMI) may increase the risk of psoriasis vulgaris, but, to our knowledge, no evidence of the combined effects of HLA-Cw6 and BMI, WHR are available. To evaluate the combined effect of HLA-Cw6, BMI and WHR on psoriasis vaulgaris. The data of 466 patients and 177 controls were investigated and analyzed by a hospital-based case-control study and non-condition logistic regress model. There was a graded positive association of WHR and BMI with psoriasis vulgaris. Compared with a WHR of 0.80 or less than 0.80, the odds ratio (OR) was 2.36 (p < 0.01) for WHR 0.80-0.85, and 2.74 (p < 0.01) for WHR greater than 0.85. Compared with subjects with a BMI of 20 or less than 20, the multivariate OR of psoriasis were 1.20 (p > 0.05) for a BMI of 20-25, 1.84 (p < 0.05) for a BMI of more than 25 corresponding overweight (p for trend, <0.01). We found not only the risk of psoriasis for the individual with HLA-Cw6+ was 8.33 times greater than that for individual with HLA-Cw6(-) but also the risk increased approximately 35 times in individuals with HLA-Cw6+ and a overweight as compared with one with HLA-Cw6(-) and a non-overweight, and 17-fold when the individuals with HLA-Cw6+ and a WHR of more than 0.80 were compared with individuals with HLA-Cw6(-) and a WHR of 0.80 or less than 0.80, displaying the combined effect of HLA-Cw6, BMI and WHR (all p < 001). This study suggested that HLA-Cw6, overweight and higher waist-hip ratio are material risk factors of psoriasis vulgaris, specially the combined effects of HLA-Cw6 and BMI, WHR on psoriasis vulgaris in Chinese population.

The hydrodynamics of linear accelerations in bluegill sunfish, Lepomis macrochirus

NASA Astrophysics Data System (ADS)

Wise, Tyler; Boden, Alex; Schwalbe, Margot; Tytell, Eric

2015-11-01

As fish swim, their body interacts with the fluid around them in order to generate thrust. In this study, we examined the hydrodynamics of linear acceleration by bluegill sunfish, Lepomis macrochirus, which swims using a carangiform mode. Carangiform swimmers primarily use their caudal fin and posterior body for propulsion, which is different from anguilliform swimmers, like eels, that undulate almost their whole body to swim. Most previous studies have examined steady swimming, but few have looked at linear accelerations, even though most fish do not often swim steadily. During steady swimming, thrust and drag forces are balanced, which makes it difficult to separate the two, but during acceleration, thrust exceeds drag, making it easier to measure; this may reveal insights into how thrust is produced. This study used particle image velocimetry (PIV) to compare the structure of the wake during steady swimming and acceleration and to estimate the axial force. Axial force increased during acceleration, but the orientation of the vortices did not differ between steady swimming and acceleration, which is different than anguilliform swimmers, whose wakes change structure during acceleration. This difference may point to fundamental differences between the two swimming modes. This material is based upon work supported by the U. S. Army Research Office under grant number W911NF-14-1-0494.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Salman, E-mail: sksafi@comsats.edu.pk

The dynamics of tripartite entanglement of fermionic system in noninertial frames through linear contraction criterion when one or two observers are accelerated is investigated. In one observer accelerated case the entanglement measurement is not invariant with respect to the partial realignment of different subsystems and for two observers accelerated case it is invariant. It is shown that the acceleration of the frame does not generate entanglement in any bipartite subsystems. Unlike the bipartite states, the genuine tripartite entanglement does not completely vanish in both one observer accelerated and two observers accelerated cases even in the limit of infinite acceleration. Themore » degradation of tripartite entanglement is fast when two observers are accelerated than when one observer is accelerated. It is shown that tripartite entanglement is a better resource for quantum information processing than the bipartite entanglement in noninertial frames. - Highlights: • Tripartite entanglement of fermionic system in noninertial frames is studied. • Linear contraction criterion for quantifying tripartite entanglement is used. • Acceleration does not produce any bipartite entanglement. • The invariance of entanglement quantifier depends on accelerated observers. • The tripartite entanglement degrades against the acceleration, it never vanishes.« less

Determination of temperature and residual laser energy on film fiber-optic thermal converter for diode laser surgery.

PubMed

Liu, Weichao; Kong, Yaqun; Shi, Xiafei; Dong, Xiaoxi; Wang, Hong; Zhao, Jizhi; Li, Yingxin

2017-12-01

The diode laser was utilized in soft tissue incision of oral surgery based on the photothermic effect. The contradiction between the ablation efficiency and the thermal damage has always been in diode laser surgery, due to low absorption of its radiation in the near infrared region by biological tissues. Fiber-optic thermal converters (FOTCs) were used to improve efficiency for diode laser surgery. The purpose of this study was to determine the photothermic effect by the temperature and residual laser energy on film FOTCs. The film FOTC was made by a distal end of optical fiber impacting on paper. The external surface of the converter is covered by a film contained amorphous carbon. The diode laser with 810 nm worked at the different rated power of 1.0 W, 1.5 W, 2.0 W, 3.0 W, 4.0 W, 5.0 W, 6.0 W, 7.0 W, 8.0 W in continuous wave (CW)and pulse mode. The temperature of the distal end of optical fiber was recorded and the power of the residual laser energy from the film FOTC was measured synchronously. The temperature, residual power and the output power were analyzed by linear or exponential regression model and Pearson correlations analysis. The residual power has good linearity versus output power in CW and pulse modes (R 2  = 0.963, P < 0.01 for both). The temperature on film FOTCs increases exponentially with adjusted R 2  = 0.959 in continuous wave mode, while in pulsed mode with adjusted R 2  = 0.934. The temperature was elevated up to about 210 °C and eventually to be a stable state. Film FOTCs centralized approximately 50% of laser energy on the fiber tip both in CW and pulsed mode while limiting the ability of the laser light to interact directly with target tissue. Film FOTCs can concentrate part of laser energy transferred to heat on distal end of optical fiber, which have the feasibility of improving efficiency and reducing thermal damage of deep tissue.

Total Warrant Officer System (TWOS). Volume 1

DTIC Science & Technology

1985-08-30

Compensation DiGirolamo, Nicholas A. CW4 OD ARNG Representative Dougherty, John R. CW4 AV Action Officer Hawk, Chuck CW4 AV Branch Chief Jinks, Dennis M. CW4...NCOIC Knight, Lewis D. SSG 81E Illustrator Cunningham, Linda L. SGT 71C Secretary/ Steno Grigsby, Steven A. SP4 64C Driver iv - ---- . "%o EXECUTIVE

Induction linear accelerators

NASA Astrophysics Data System (ADS)

Birx, Daniel

1992-03-01

Among the family of particle accelerators, the Induction Linear Accelerator is the best suited for the acceleration of high current electron beams. Because the electromagnetic radiation used to accelerate the electron beam is not stored in the cavities but is supplied by transmission lines during the beam pulse it is possible to utilize very low Q (typically<10) structures and very large beam pipes. This combination increases the beam breakup limited maximum currents to of order kiloamperes. The micropulse lengths of these machines are measured in 10's of nanoseconds and duty factors as high as 10-4 have been achieved. Until recently the major problem with these machines has been associated with the pulse power drive. Beam currents of kiloamperes and accelerating potentials of megavolts require peak power drives of gigawatts since no energy is stored in the structure. The marriage of liner accelerator technology and nonlinear magnetic compressors has produced some unique capabilities. It now appears possible to produce electron beams with average currents measured in amperes, peak currents in kiloamperes and gradients exceeding 1 MeV/meter, with power efficiencies approaching 50%. The nonlinear magnetic compression technology has replaced the spark gap drivers used on earlier accelerators with state-of-the-art all-solid-state SCR commutated compression chains. The reliability of these machines is now approaching 1010 shot MTBF. In the following paper we will briefly review the historical development of induction linear accelerators and then discuss the design considerations.

Quantitative Approach to Failure Mode and Effect Analysis for Linear Accelerator Quality Assurance

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Daniel, Jennifer C., E-mail: jennifer.odaniel@duke.edu; Yin, Fang-Fang

Purpose: To determine clinic-specific linear accelerator quality assurance (QA) TG-142 test frequencies, to maximize physicist time efficiency and patient treatment quality. Methods and Materials: A novel quantitative approach to failure mode and effect analysis is proposed. Nine linear accelerator-years of QA records provided data on failure occurrence rates. The severity of test failure was modeled by introducing corresponding errors into head and neck intensity modulated radiation therapy treatment plans. The relative risk of daily linear accelerator QA was calculated as a function of frequency of test performance. Results: Although the failure severity was greatest for daily imaging QA (imaging vsmore » treatment isocenter and imaging positioning/repositioning), the failure occurrence rate was greatest for output and laser testing. The composite ranking results suggest that performing output and lasers tests daily, imaging versus treatment isocenter and imaging positioning/repositioning tests weekly, and optical distance indicator and jaws versus light field tests biweekly would be acceptable for non-stereotactic radiosurgery/stereotactic body radiation therapy linear accelerators. Conclusions: Failure mode and effect analysis is a useful tool to determine the relative importance of QA tests from TG-142. Because there are practical time limitations on how many QA tests can be performed, this analysis highlights which tests are the most important and suggests the frequency of testing based on each test's risk priority number.« less

Interplay effect on a 6-MV flattening-filter-free linear accelerator with high dose rate and fast multi-leaf collimator motion treating breast and lung phantoms.

PubMed

Netherton, Tucker; Li, Yuting; Nitsch, Paige; Shaitelman, Simona; Balter, Peter; Gao, Song; Klopp, Ann; Muruganandham, Manickam; Court, Laurence

2018-06-01

Using a new linear accelerator with high dose rate (800 MU/min), fast MLC motions (5.0 cm/s), fast gantry rotation (15 s/rotation), and 1 cm wide MLCs, we aimed to quantify the effects of complexity, arc number, and fractionation on interplay for breast and lung treatments under target motion. To study lung interplay, eight VMAT plans (1-6 arcs) and four-nine-field sliding-window IMRT plans varying in complexity were created. For the breast plans, four-four-field sliding-window IMRT plans were created. Using the Halcyon 1.0 linear accelerator, each plan was delivered five times each under sinusoidal breathing motion to a phantom with 20 implanted MOSFET detectors; MOSFET dose (cGy), delivery time, and MU/cGy values were recorded. Maximum and mean dose deviations were calculated from MOSFET data. The number of MOSFETs with at least 19 of 20 detectors agreeing with their expected dose within 5% per fraction was calculated across 10 6 iterations to model dose deviation as function of fraction number for all plan variants. To put interplay plans into clinical context, additional IMRT and VMAT plans were created and delivered for the sites of head and neck, prostate, whole brain, breast, pelvis, and lung. Average modulation and interplay effect were compared to those from conventional linear accelerators, as reported from previous studies. The mean beam modulation for plans created for the Halcyon 1.0 linear accelerator was 2.9 MU/cGy (two- to four-field IMRT breast plans), 6.2 MU/cGy (at least five-field IMRT), and 3.6 MU/cGy (four-arc VMAT). To achieve treatment plan objectives, Halcyon 1.0 VMAT plans require more arcs and modulation than VMAT on conventional linear accelerators. Maximum and mean dose deviations increased with increasing plan complexity under tumor motion for breast and lung treatments. Concerning VMAT plans under motion, maximum, and mean dose deviations were higher for one arc than for two arcs regardless of plan complexity. For plan variants with maximum dose deviations greater than 3.7%, dose deviation as a function of fraction number was protracted. For treatments on the Halcyon 1.0 linear accelerator, the convergence of dose deviation with fraction number happened more slowly than reported for conventional linear accelerators. However, if plan complexity is reduced for IMRT and if tumor motion is less than ~10-mm, interplay is greatly reduced. To minimize dose deviations across multiple fractions for dynamic targets, we recommend limiting treatment plan complexity and avoiding one-arc VMAT on the Halcyon 1.0 linear accelerator when interplay is a concern. © 2018 American Association of Physicists in Medicine.

Introduction

NASA Astrophysics Data System (ADS)

Takayama, Ken; Briggs*, Richard J.

The motivation for the initial development of linear induction accelerators starting in the early 1960s came mainly from applications requiring intense electron pulses with beam currents and a charge per pulse above the range accessible to RF accelerators, and with particle energies beyond the capabilities of single stage pulsed-power diodes. The linear induction accelerators developed to meet these needs utilize a series of induction cells containing magnetic cores (torroidal geometry) driven directly by pulse modulators (pulsed power sources). This multistage "one-to-one transformer" configuration with non-resonant, low impedance induction cells accelerates kilo-Ampere-scale electron beam current pulses in induction linacs.

Beam breakup in an advanced linear induction accelerator

DOE PAGES

Ekdahl, Carl August; Coleman, Joshua Eugene; McCuistian, Brian Trent

2016-07-01

Two linear induction accelerators (LIAs) have been in operation for a number of years at the Los Alamos Dual Axis Radiographic Hydrodynamic Test (DARHT) facility. A new multipulse LIA is being developed. We have computationally investigated the beam breakup (BBU) instability in this advanced LIA. In particular, we have explored the consequences of the choice of beam injector energy and the grouping of LIA cells. We find that within the limited range of options presently under consideration for the LIA architecture, there is little adverse effect on the BBU growth. The computational tool that we used for this investigation wasmore » the beam dynamics code linear accelerator model for DARHT (LAMDA). In conclusion, to confirm that LAMDA was appropriate for this task, we first validated it through comparisons with the experimental BBU data acquired on the DARHT accelerators.« less

SYMBMAT: Symbolic computation of quantum transition matrix elements

NASA Astrophysics Data System (ADS)

Ciappina, M. F.; Kirchner, T.

2012-08-01

We have developed a set of Mathematica notebooks to compute symbolically quantum transition matrices relevant for atomic ionization processes. The utilization of a symbolic language allows us to obtain analytical expressions for the transition matrix elements required in charged-particle and laser induced ionization of atoms. Additionally, by using a few simple commands, it is possible to export these symbolic expressions to standard programming languages, such as Fortran or C, for the subsequent computation of differential cross sections or other observables. One of the main drawbacks in the calculation of transition matrices is the tedious algebraic work required when initial states other than the simple hydrogenic 1s state need to be considered. Using these notebooks the work is dramatically reduced and it is possible to generate exact expressions for a large set of bound states. We present explicit examples of atomic collisions (in First Born Approximation and Distorted Wave Theory) and laser-matter interactions (within the Dipole and Strong Field Approximations and different gauges) using both hydrogenic wavefunctions and Slater-Type Orbitals with arbitrary nlm quantum numbers as initial states. Catalogue identifier: AEMI_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMI_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC license, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 71 628 No. of bytes in distributed program, including test data, etc.: 444 195 Distribution format: tar.gz Programming language: Mathematica Computer: Single machines using Linux or Windows (with cores with any clock speed, cache memory and bits in a word) Operating system: Any OS that supports Mathematica. The notebooks have been tested under Windows and Linux and with versions 6.x, 7.x and 8.x Classification: 2.6 Nature of problem: The notebooks generate analytical expressions for quantum transition matrix elements required in diverse atomic processes: ionization by ion, electron, or photon impact and ionization within the framework of strong field physics. In charged-particle collisions approaches based on perturbation theory enjoy widespread utilization. Accordingly, we have chosen the First Born Approximation and Distorted Wave theories as examples. In light-matter interactions, the main ingredient for many types of calculations is the dipole transition matrix in its different formulations, i.e. length, velocity, and acceleration gauges. In all these cases the transitions of interest occur between a bound state and a continuum state which can be described in different ways. With the notebooks developed in the present work it is possible to calculate transition matrix elements analytically for any set of quantum numbers nlm of initial hydrogenic states or Slater-Type Orbitals and for plane waves or Coulomb waves as final continuum states. Solution method: The notebooks employ symbolic computation to generate analytical expressions for transition matrix elements used in both collision and light-matter interaction physics. fba_hyd.nb - This notebook computes analytical expressions for the transition matrix of collision-induced ionization in the First Born Approximation (FBA). The transitions considered are from a bound hydrogenic state with arbitrary quantum numbers nlm to a continuum state represented by a plane wave (PW) or a Coulomb wave (CW). distorted_hyd.nb - This notebook computes analytical expressions for the transition matrix of collision-induced ionization in Distorted Wave (DW) theories. The transitions considered are from a (distorted) bound hydrogenic state with arbitrary quantum numbers nlm to a distorted-wave continuum state. The computations are based on scalar and vectorial integrals (see the text for details). dipoleLength_hyd.nb - This notebook computes analytical expressions for the dipole transition matrix in length gauge. The transitions considered are from a bound hydrogenic state with arbitrary quantum numbers nlm to a continuum state represented by a PW (the Strong Field Approximation (SFA)) or a CW (the Coulomb-Volkov Approximation (CVA)). dipoleVelocity_hyd.nb - This notebook computes analytical expressions for the dipole transition matrix in velocity gauge. The transitions considered are from a bound hydrogenic state with arbitrary quantum numbers nlm to a continuum state represented by a PW (the SFA) or a CW (the CVA). dipoleAcceleration_hyd.nb - This notebook computes analytical expressions for the dipole transition matrix in acceleration gauge. The transitions considered are from a bound hydrogenic state with arbitrary quantum numbers nlm to a continuum state represented by a PW (the SFA). For the case of the CVA we only include the transition from the 1s state to a continuum state represented by a CW. fba_STO.nb - This notebook computes analytical expressions for the transition matrix of collision-induced ionization in the FBA. The transitions considered are from a Slater-Type Orbital (STO) with arbitrary quantum numbers nlm to a continuum state represented by a PW or a CW. distorted_STO.nb - This notebook computes analytical expressions for the transition matrix of collision-induced ionization in DW theories. The transitions considered are from a (distorted) STO with arbitrary quantum numbers nlm to a distorted-wave continuum state. The computations are based on scalar and vectorial integrals (see the text for details). dipoleLength_STO.nb - This notebook computes analytical expressions for the dipole transition matrix in length gauge. The transitions considered are from an STO with arbitrary quantum numbers nlm to a continuum state represented by a PW (the SFA) or a CW (the CVA). dipoleVelocity_STO.nb - This notebook computes analytical expressions for the dipole transition matrix in velocity gauge. The transitions considered are from an STO with arbitrary quantum numbers nlm to a continuum state represented by a PW (the SFA) or a CW (the CVA). dipoleAcceleration_STO.nb - This notebook computes analytical expressions for the dipole transition matrix in acceleration gauge. The transitions considered are from an STO with arbitrary quantum numbers nlm to a continuum state represented by a PW (the SFA). The symbolic expressions obtained within each notebook can be exported to standard programming languages such as Fortran or C using the Format.m package (see the text and Ref. Sofroniou (1993) [16] for details). Running time: Computational times vary according to the transition matrix selected and quantum numbers nlm of the initial state used. The typical running time is several minutes, but it will take longer for large values of nlm.

Motion sickness and otolith sensitivity - A pilot study of habituation to linear acceleration

NASA Technical Reports Server (NTRS)

Potvin, A. R.; Sadoff, M.; Billingham, J.

1977-01-01

Astronauts, particularly in Skylab flights, experienced varying degrees of motion sickness lasting 3-5 days. One possible mechanism for this motion sickness adaptation is believed to be a reduction in otolith sensitivity with an attendant reduction in sensory conflict. In an attempt to determine if this hypothesis is valid, a ground-based pilot study was conducted on a vertical linear accelerator. The extent of habituation to accelerations which initially produced motion sickness was evaluated, along with the possible value of habituation training to minimize the space motion sickness problem. Results showed that habituation occurred for 6 of the 8 subjects tested. However, in tests designed to measure dynamic and static otolith function, no significant differences between pre- and post-habituation tests were observed. Cross habituation effects to a standard Coriolis acceleration test were not significant. It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness.

Orbit covariance propagation via quadratic-order state transition matrix in curvilinear coordinates

NASA Astrophysics Data System (ADS)

Hernando-Ayuso, Javier; Bombardelli, Claudio

2017-09-01

In this paper, an analytical second-order state transition matrix (STM) for relative motion in curvilinear coordinates is presented and applied to the problem of orbit uncertainty propagation in nearly circular orbits (eccentricity smaller than 0.1). The matrix is obtained by linearization around a second-order analytical approximation of the relative motion recently proposed by one of the authors and can be seen as a second-order extension of the curvilinear Clohessy-Wiltshire (C-W) solution. The accuracy of the uncertainty propagation is assessed by comparison with numerical results based on Monte Carlo propagation of a high-fidelity model including geopotential and third-body perturbations. Results show that the proposed STM can greatly improve the accuracy of the predicted relative state: the average error is found to be at least one order of magnitude smaller compared to the curvilinear C-W solution. In addition, the effect of environmental perturbations on the uncertainty propagation is shown to be negligible up to several revolutions in the geostationary region and for a few revolutions in low Earth orbit in the worst case.

Coherent multi-heterodyne spectroscopy using acousto-optic frequency combs.

PubMed

Durán, Vicente; Schnébelin, Cȏme; Guillet de Chatellus, Hugues

2018-05-28

We propose and characterize experimentally a new source of optical frequency combs for performing multi-heterodyne spectrometry. This comb modality is based on a frequency-shifting loop seeded with a continuous-wave (CW) monochromatic laser. The comb lines are generated by successive passes of the CW laser through an acousto-optic frequency shifter. We report the generation of frequency combs with more than 1500 mutually coherent lines, without resorting to non-linear broadening phenomena or external electronic modulation. The comb line spacing is easily reconfigurable from tens of MHz down to the kHz region. We first use a single acousto-optic frequency comb to conduct self-heterodyne interferometry with a high frequency resolution (500 kHz). By increasing the line spacing to 80 MHz, we demonstrate molecular spectroscopy on the sub-millisecond time scale. In order to reduce the detection bandwidth, we subsequently implement an acousto-optic dual-comb spectrometer with the aid of two mutually coherent frequency shifting loops. In each architecture, the potentiality of acousto-optic frequency combs for spectroscopy is validated by spectral measurements of hydrogen cyanide in the near-infrared region.

Coherent multi-heterodyne spectroscopy using acousto-optic frequency combs

NASA Astrophysics Data System (ADS)

Durán, Vicente; Schnébelin, Cȏme; Guillet de Chatellus, Hugues

2018-05-01

We propose and characterize experimentally a new source of optical frequency combs for performing multi-heterodyne spectrometry. This comb modality is based on a frequency shifting loop seeded with a CW monochromatic laser. The comb lines are generated by successive passes of the CW laser through an acousto-optic frequency shifter. We report the generation of frequency combs with more than 1500 mutually coherent lines, without resorting to non-linear broadening phenomena or external electronic modulation. The comb line spacing is easily reconfigurable from tens of MHz down to the kHz region. We first use a single acousto-optic frequency comb to conduct self-heterodyne interferometry with a high frequency resolution (500 kHz). By increasing the line spacing to 80 MHz, we demonstrate molecular spectroscopy on the sub-millisecond time scale. In order to reduce the detection bandwidth, we subsequently implement an acousto-optic dual-comb spectrometer with the aid of two mutually coherent frequency shifting loops. In each architecture, the potentiality of acousto-optic frequency combs for spectroscopy is validated by spectral measurements of hydrogen cyanide in the near-infrared region.

Dual line CW fiber laser module based on FBG combination

NASA Astrophysics Data System (ADS)

Dobashi, Kazuma; Hoshi, Masayuki; Hirohashi, Junji; Makio, Satoshi

2018-02-01

We developed the dual line fiber laser module based on FBG combination. The proposed configuration has several advantages such as compact, simple, and inexpensive. The laser was composed pump LD (40W), two HR FBGs for 1053 nm and 1058 nm, Yb-doped fiber, two OC FBGs for 1053 nm and 1058 nm, and delivery fiber. All single mode fibers were polarization maintained with approximately 6 micron core. All FBGs were mounted on holders with TECs and their temperatures were controlled independently. The center wavelengths of HR and OC FBGs were temperature dependent and their shifts are approximately 7 nm/degree-C for all integrated FBG. By adjusting the temperature, it is possible to realize the resonant condition for only 1053 nm or only for 1058 nm. Based on this configuration, we demonstrated dual line CW fiber laser module. This module was compact with the size of 200 mm X 150 mm X 23 mm. By adjusting the FBG temperatures, we obtained the output power of more than 10 W at 1053 nm and 1058 nm with linear polarization.

TL-OSL correlation studies of LiMgPO4:Tb,B dosimetric phosphor

NASA Astrophysics Data System (ADS)

Singh, A. K.; Menon, S. N.; Dhabekar, Bhushan; Kadam, Sonal; Chougaonkar, M. P.; Mayya, Y. S.

2012-03-01

The recently synthesized LiMgPO4:Tb,B (LMP) is a highly sensitive Optically Stimulated Luminescence (OSL) phosphor for dosimetric applications. Studies were carried out to assess the correlation between thermoluminescence (TL) and OSL of this phosphor. Measurements like Residual TL (R-TL), Continuous Wave OSL (CW-OSL) and Linearly Modulated OSL (LM-OSL) of LMP were carried out and various curves thus obtained were de-convolved using Computerized Curve Deconvolution (CCD) program. The deconvolution of CW-OSL and LM-OSL curves showed five different first order components in LMP. It was observed that OSL signal of LMP has its origin from five traps having different photo-ionization cross-sections. Same traps were found to be responsible for both TL and OSL in this phosphor. Bleaching decay rates were calculated for each R-TL glow peaks and compared with the decay rates of individual OSL components. The value of decay rates of R-TL and OSL matches well. Experimental verification of presence of individual OSL components using tbleach-tmax method was carried out.

First study to explore the feasibility of applying microbial fuel cells into constructed wetlands for COD monitoring.

PubMed

Xu, Lei; Zhao, Yaqian; Fan, Chuang; Fan, Zhiren; Zhao, Fangchao

2017-11-01

Chemical oxygen demand (COD) is one of the major targets to remove in constructed wetlands (CWs) system. Traditional method for COD measurement is a complex, time-consuming and highly toxic reagents participated procedure. In this study, microbial fuel cell (MFC) was successfully integrated into CW for indicating COD concentration. Results showed that there are two linear correlations between bioelectrical signals (output voltage from MFC) and COD concentration (acetate), which are COD from 0 to 500mg/L (101.99±7.42 to 631.74±7.41mV, R 2 =0.9710) and then from 500 to 1000mg/L (631.74±7.41 to 668.46±0.01mV, R 2 =0.9245). Furthermore, results also revealed the specificity of the system in terms of different types of carbon source. Overall, this work presented the feasibility of using CW-MFC for in-situ sensing COD during the wastewater treatment process, which will be a promising technique for water quality monitoring within CWs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Microwave and Electron Beam Computer Programs

DTIC Science & Technology

1988-06-01

Research (ONR). SCRIBE was adapted by MRC from the Stanford Linear Accelerator Center Beam Trajectory Program, EGUN . oTIC NSECE Acc !,,o For IDL1C I...achieved with SCRIBE. It is a ver- sion of the Stanford Linear Accelerator (SLAC) code EGUN (Ref. 8), extensively modified by MRC for research on

SOME PROBLEMS IN THE CONSTRUCTION OF AN ELECTRON LINEAR ACCELERATOR (in Dutch)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Verhaeghe, J.; Vanhuyse, V.; Van Leuven, P.

1959-01-01

Special problems encountered in the construction of the electron linear accelerator of the Natuurkundig Laboratorium der Rijksuniversiteit of Ghent are discussed. The subjects considered are magnetic focusing, magnetic screening of the electron gun cathode, abnormal attenuation-multipactor effects, and electron energy control. (J.S.R.)

Behind the Scenes of the Spallation Neutron Source – The Linear Accelerator

ScienceCinema

Galambos, John

2018-06-25

The Spallation Neutron Source at Oak Ridge National Laboratory is a one-of-a-kind research facility that provides the most intense pulsed neutron beams in the world for scientific research and industrial development. Take a look inside the facility's linear accelerator.

Arbuscular mycorrhizal fungi in two vertical-flow wetlands constructed for heavy metal-contaminated wastewater bioremediation.

PubMed

Xu, Zhouying; Wu, Yang; Jiang, Yinghe; Zhang, Xiangling; Li, Junli; Ban, Yihui

2018-05-01

Over the last three decades, the presence of arbuscular mycorrhizal fungi (AMF) in wetland habitats had been proven, and their roles played in wetland ecosystems and potential functions in wastewater bioremediation technical installations are interesting issues. To increase knowledge on the functions of AMF in the plant-based bioremediation of wastewater, we constructed two vertical-flow wetlands planting with Phragmites australis and investigated AMF distribution in plant roots and their roles played in purification of wastewater polluted by heavy metals (HMs), utilizing the Illumina sequencing technique. A total of 17 operational taxonomic units (OTUs) from 33,031 AMF sequences were obtained, with Glomus being the most dominant. P. australis living in the two vertical-flow constructed wetlands (CWs) harbored diverse AMF comparable with the AM fungal communities in upland habitats. The AMF composition profiles of CW1 (vegetated with non-inoculated plants) and CW2 (vegetated with mycorrhizal plants inoculated with Rhizophagus intraradices) were significantly different. CW1 (15 OTUs) harbored more diverse AMF than CW2 (7 OTUs); however, CW2 harbored much more OTU13 than CW1. In addition, a zipf species abundance distribution (SAD), which might due to the heavy overdominance of OTU13, was observed across AM fugal taxa in P. australis roots of the two CWs. CW1 and CW2 showed high (> 70%) removal capacity of HMs. CW2 exhibited significant higher Cd and Zn removal efficiencies than CW1 (CK) (p = 0.005 and p = 0.008, respectively). It was considered that AMF might play a role in HM removal in CWs.

Radio frequency quadrupole resonator for linear accelerator

DOEpatents

Moretti, Alfred

1985-01-01

An RFQ resonator for a linear accelerator having a reduced level of interfering modes and producing a quadrupole mode for focusing, bunching and accelerating beams of heavy charged particles, with the construction being characterized by four elongated resonating rods within a cylinder with the rods being alternately shorted and open electrically to the shell at common ends of the rods to provide an LC parallel resonant circuit when activated by a magnetic field transverse to the longitudinal axis.

Radio-frequency quadrupole resonator for linear accelerator

DOEpatents

Moretti, A.

1982-10-19

An RFQ resonator for a linear accelerator having a reduced level of interfering modes and producing a quadrupole mode for focusing, bunching and accelerating beams of heavy charged particles, with the construction being characterized by four elongated resonating rods within a cylinder with the rods being alternately shorted and open electrically to the shell at common ends of the rods to provide an LC parallel resonant circuit when activated by a magnetic field transverse to the longitudinal axis.

Vestibular coriolis effect differences modeled with three-dimensional linear-angular interactions.

PubMed

Holly, Jan E

2004-01-01

The vestibular coriolis (or "cross-coupling") effect is traditionally explained by cross-coupled angular vectors, which, however, do not explain the differences in perceptual disturbance under different acceleration conditions. For example, during head roll tilt in a rotating chair, the magnitude of perceptual disturbance is affected by a number of factors, including acceleration or deceleration of the chair rotation or a zero-g environment. Therefore, it has been suggested that linear-angular interactions play a role. The present research investigated whether these perceptual differences and others involving linear coriolis accelerations could be explained under one common framework: the laws of motion in three dimensions, which include all linear-angular interactions among all six components of motion (three angular and three linear). The results show that the three-dimensional laws of motion predict the differences in perceptual disturbance. No special properties of the vestibular system or nervous system are required. In addition, simulations were performed with angular, linear, and tilt time constants inserted into the model, giving the same predictions. Three-dimensional graphics were used to highlight the manner in which linear-angular interaction causes perceptual disturbance, and a crucial component is the Stretch Factor, which measures the "unexpected" linear component.

Tools for the Future of Nuclear Physics

NASA Astrophysics Data System (ADS)

Geesaman, Donald

2014-03-01

The challenges of Nuclear Physics, especially in understanding strongly interacting matter in all its forms in the history of the universe, place ever higher demands on the tools of the field, including the workhorse, accelerators. These demands are not just higher energy and higher luminosity. To recreate the matter that fleetingly was formed in the origin of the heavy elements, we need higher power heavy-ion accelerators and creative techniques to harvest the isotopes. We also need high-current low-energy accelerators deep underground to detect the very slow rate reactions in stellar burning. To explore the three dimensional distributions of high-momentum quarks in hadrons and to search for gluonic excitations we need high-current CW electron accelerators. Understanding the gluonic structure of nuclei and the three dimensional distributions of partons at lower x, we need high-luminosity electron-ion colliders that also have the capabilities to prepare, preserve and manipulate the polarization of both beams. A search for the critical point in the QCD phase diagram demands high luminosity beams over a broad range of species and energy. With advances in cavity design and construction, beam manipulation and cooling, and ion sources and targets, the Nuclear Physics community, in the U.S. and internationally has a coordinated vision to deliver this exciting science. This work is supported by DOE, Office of Nuclear Physics, under contract DE-AC02-06CH11357.

A 10 Billion MeV Cyclotron

ERIC Educational Resources Information Center

Edge, R. D.

1974-01-01

Discusses the design of a device which serves to demonstrate the principle of acceleration and phase stability by accelerating gravitationally a ball bearing along a spiral groove. Application of the design principle to the acceleration aspect of a linear accelerator is recommended. (CC)

Electron stripping processes of H{sup −} ion beam in the 80 kV high voltage extraction column and low energy beam transport line at LANSCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draganic, I. N., E-mail: draganic@lanl.gov

Basic vacuum calculations were performed for various operating conditions of the Los Alamos National Neutron Science H{sup −} Cockcroft-Walton (CW) injector and the Ion Source Test Stand (ISTS). The vacuum pressure was estimated for both the CW and ISTS at five different points: (1) inside the H{sup −} ion source, (2) in front of the Pierce electrode, (3) at the extraction electrode, (4) at the column electrode, and (5) at the ground electrode. A static vacuum analysis of residual gases and the working hydrogen gas was completed for the normal ion source working regime. Gas density and partial pressure weremore » estimated for the injected hydrogen gas. The attenuation of H{sup −} beam current and generation of electron current in the high voltage acceleration columns and low energy beam transport lines were calculated. The interaction of H{sup −} ions on molecular hydrogen (H{sub 2}) is discussed as a dominant collision process in describing electron stripping rates. These results are used to estimate the observed increase in the ratio of electrons to H{sup −} ion beam in the ISTS beam transport line.« less

Beam-driven acceleration in ultra-dense plasma media

DOE PAGES

Shin, Young-Min

2014-09-15

Accelerating parameters of beam-driven wakefield acceleration in an extremely dense plasma column has been analyzed with the dynamic framed particle-in-cell plasma simulator, and compared with analytic calculations. In the model, a witness beam undergoes a TeV/m scale alternating potential gradient excited by a micro-bunched drive beam in a 10 25 m -3 and 1.6 x 10 28 m -3 plasma column. The acceleration gradient, energy gain, and transformer ratio have been extensively studied in quasi-linear, linear-, and blowout-regimes. The simulation analysis indicated that in the beam-driven acceleration system a hollow plasma channel offers 20 % higher acceleration gradient by enlargingmore » the channel radius (r) from 0.2 Ap to 0.6 .Ap in a blowout regime. This paper suggests a feasibility of TeV/m scale acceleration with a hollow crystalline structure (e.g. nanotubes) of high electron plasma density.« less

The adequate stimulus for avian short latency vestibular responses to linear translation

NASA Technical Reports Server (NTRS)

Jones, T. A.; Jones, S. M.; Colbert, S.

1998-01-01

Transient linear acceleration stimuli have been shown to elicit eighth nerve vestibular compound action potentials in birds and mammals. The present study was undertaken to better define the nature of the adequate stimulus for neurons generating the response in the chicken (Gallus domesticus). In particular, the study evaluated the question of whether the neurons studied are most sensitive to the maximum level of linear acceleration achieved or to the rate of change in acceleration (da/dt, or jerk). To do this, vestibular response thresholds were measured as a function of stimulus onset slope. Traditional computer signal averaging was used to record responses to pulsed linear acceleration stimuli. Stimulus onset slope was systematically varied. Acceleration thresholds decreased with increasing stimulus onset slope (decreasing stimulus rise time). When stimuli were expressed in units of jerk (g/ms), thresholds were virtually constant for all stimulus rise times. Moreover, stimuli having identical jerk magnitudes but widely varying peak acceleration levels produced virtually identical responses. Vestibular response thresholds, latencies and amplitudes appear to be determined strictly by stimulus jerk magnitudes. Stimulus attributes such as peak acceleration or rise time alone do not provide sufficient information to predict response parameter quantities. Indeed, the major response parameters were shown to be virtually independent of peak acceleration levels or rise time when these stimulus features were isolated and considered separately. It is concluded that the neurons generating short latency vestibular evoked potentials do so as "jerk encoders" in the chicken. Primary afferents classified as "irregular", and which traditionally fall into the broad category of "dynamic" or "phasic" neurons, would seem to be the most likely candidates for the neural generators of short latency vestibular compound action potentials.

Influence of tungsten fiber’s slow drift on the measurement of G with angular acceleration method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, Jie; Wu, Wei-Huang; Zhan, Wen-Ze

In the measurement of the gravitational constant G with angular acceleration method, the equilibrium position of torsion pendulum with tungsten fiber undergoes a linear slow drift, which results in a quadratic slow drift on the angular velocity of the torsion balance turntable under feedback control unit. The accurate amplitude determination of the useful angular acceleration signal with known frequency is biased by the linear slow drift and the coupling effect of the drifting equilibrium position and the room fixed gravitational background signal. We calculate the influences of the linear slow drift and the complex coupling effect on the value ofmore » G, respectively. The result shows that the bias of the linear slow drift on G is 7 ppm, and the influence of the coupling effect is less than 1 ppm.« less

Influence of tungsten fiber's slow drift on the measurement of G with angular acceleration method.

PubMed

Luo, Jie; Wu, Wei-Huang; Xue, Chao; Shao, Cheng-Gang; Zhan, Wen-Ze; Wu, Jun-Fei; Milyukov, Vadim

2016-08-01

In the measurement of the gravitational constant G with angular acceleration method, the equilibrium position of torsion pendulum with tungsten fiber undergoes a linear slow drift, which results in a quadratic slow drift on the angular velocity of the torsion balance turntable under feedback control unit. The accurate amplitude determination of the useful angular acceleration signal with known frequency is biased by the linear slow drift and the coupling effect of the drifting equilibrium position and the room fixed gravitational background signal. We calculate the influences of the linear slow drift and the complex coupling effect on the value of G, respectively. The result shows that the bias of the linear slow drift on G is 7 ppm, and the influence of the coupling effect is less than 1 ppm.

Influence of tungsten fiber's slow drift on the measurement of G with angular acceleration method

NASA Astrophysics Data System (ADS)

Luo, Jie; Wu, Wei-Huang; Xue, Chao; Shao, Cheng-Gang; Zhan, Wen-Ze; Wu, Jun-Fei; Milyukov, Vadim

2016-08-01

In the measurement of the gravitational constant G with angular acceleration method, the equilibrium position of torsion pendulum with tungsten fiber undergoes a linear slow drift, which results in a quadratic slow drift on the angular velocity of the torsion balance turntable under feedback control unit. The accurate amplitude determination of the useful angular acceleration signal with known frequency is biased by the linear slow drift and the coupling effect of the drifting equilibrium position and the room fixed gravitational background signal. We calculate the influences of the linear slow drift and the complex coupling effect on the value of G, respectively. The result shows that the bias of the linear slow drift on G is 7 ppm, and the influence of the coupling effect is less than 1 ppm.

Removal of nutrients from septic tank effluent with baffle subsurface-flow constructed wetlands

Treesearch

Lihu Cui; Ying Ouyang; Weizhi Yang; Zhujian Huang; Qiaoling Xu; Guangwei Yu

2015-01-01

Three new baffle flow constructed wetlands (CWs), namely the baffle horizontal flow CW (Z1), baffle vertical flow CW (Z2) and baffle hybrid flow CW (Z3), along with one traditional horizontal subsurface flow CW (Z4) were designed to test the removal efficiency of nitrogen (N) and phosphorus (P) from the septic tank effluent under varying hydraulic retention times (HRTs...

Performance of different substrates in constructed wetlands planted with E. crassipes treating low-strength sewage under subtropical conditions.

PubMed

Lima, M X; Carvalho, K Q; Passig, F H; Borges, A C; Filippe, T C; Azevedo, J C R; Nagalli, A

2018-07-15

The present study aimed to assess removal potential of chemical oxygen demand (COD), total Kjeldahl nitrogen (TKN), total ammonia nitrogen (TAN), total phosphorus (TP) and acetylsalicylic acid (ASA) in synthetic wastewater simulating low-strength sewage by sequencing-batch mode constructed wetlands (CWs). Six CWs with three substrates (gravel, light expanded clay and clay bricks) and one CW of each substrate was planted with E. crassipes to verify the feasibility of using a floating macrophyte in CWs and verify the best optimized substrate. Results showed that the presence of E. crassipes enhanced the removal of COD for systems with gravel, increasing the removal efficiency from 37% in the unplanted system (CW G-U ) to 60% in the planted system (CW G-P ). The vegetated CW with clay bricks (CW B-P ) presented the best performance for both TKN and TAN removal, with maximum removal efficiencies of 68% and 35%, respectively. Phosphorus was observed to be efficiently removed in systems with clay bricks, both planted (CW B-U ) and unplanted (CW B-P ), with mean removal efficiencies of 82% and 87%, respectively, probably via adsorption. It was also observed that after 296days of operation, no desorption or increase on phosphorus in effluent samples were observed, thus indicating that the material was not yet saturated and phosphorus probably presents a strong binding to the media. ASA removal efficiency varied from 34% to 92% in CWs, probably due to plant uptake through roots and microbial biodegradation. Plant direct uptake varied from 4 to 74% of the total nitrogen and from 26 to 71% of the total phosphorus removed in CW G-P , CW C-P and CW B-P . E. crassipes was able to uptake up to 4.19g of phosphorus in CW C-P and 11.84g of nitrogen in CW B-P . The findings on this study suggest that E. crassipes could be used in CWs and clay bricks could significantly enhance phosphorus removal capacity in CWs. Copyright © 2018 Elsevier B.V. All rights reserved.

Cell wall composition and digestibility alterations in Brachypodium distachyon achieved through reduced expression of the UDP-arabinopyranose mutase

PubMed Central

Rancour, David M.; Hatfield, Ronald D.; Marita, Jane M.; Rohr, Nicholas A.; Schmitz, Robert J.

2015-01-01

Nucleotide-activated sugars are essential substrates for plant cell-wall carbohydrate-polymer biosynthesis. The most prevalent grass cell wall (CW) sugars are glucose (Glc), xylose (Xyl), and arabinose (Ara). These sugars are biosynthetically related via the UDP–sugar interconversion pathway. We sought to target and generate UDP–sugar interconversion pathway transgenic Brachypodium distachyon lines resulting in CW carbohydrate composition changes with improved digestibility and normal plant stature. Both RNAi-mediated gene-suppression and constitutive gene-expression approaches were performed. CWs from 336 T0 transgenic plants with normal appearance were screened for complete carbohydrate composition. RNAi mutants of BdRGP1, a UDP-arabinopyranose mutase, resulted in large alterations in CW carbohydrate composition with significant decreases in CW Ara content but with minimal change in plant stature. Five independent RNAi-RGP1 T1 plant lines were used for in-depth analysis of plant CWs. Real-time PCR analysis indicated that gene expression levels for BdRGP1, BdRGP2, and BdRGP3 were reduced in RNAi-RGP1 plants to 15–20% of controls. CW Ara content was reduced by 23–51% of control levels. No alterations in CW Xyl and Glc content were observed. Corresponding decreases in CW ferulic acid (FA) and ferulic acid-dimers (FA-dimers) were observed. Additionally, CW p-coumarates (pCA) were decreased. We demonstrate the CW pCA decrease corresponds to Ara-coupled pCA. Xylanase-mediated digestibility of RNAi-RGP1 Brachypodium CWs resulted in a near twofold increase of released total carbohydrate. However, cellulolytic hydrolysis of CW material was inhibited in leaves of RNAi-RGP1 mutants. Our results indicate that targeted manipulation of UDP–sugar biosynthesis can result in biomass with substantially altered compositions and highlights the complex effect CW composition has on digestibility. PMID:26136761

Calculations of beam dynamics in Sandia linear electron accelerators, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poukey, J.W.; Coleman, P.D.

1985-03-01

A number of code and analytic studies were made during 1984 which pertain to the Sandia linear accelerators MABE and RADLAC. In this report the authors summarize the important results of the calculations. New results include a better understanding of gap-induced radial oscillations, leakage currents in a typical MABE gas, emittance growth in a beam passing through a series of gaps, some new diocotron results, and the latest diode simulations for both accelerators. 23 references, 30 figures, 1 table.

Numerical Modeling of the Nearshore Region.

DTIC Science & Technology

1982-06-01

Model 10 f = 0.01 i0 _ -- 2 Linear’Model f = 0.015 - 3 Linear Modelf 0 .02 EN 41 Data Set 1 600- U 40 4 -C 20 T Longshore Current Velocity V (r/sec...IX CZ Oxn 0 00 Cw LU 39’L 0f C:1- 3 LU x 4 3 00 0~ ~ -L U - 3 0 0 f, c0 ID - ox (9 o. 0 o4, n -i u x --- C- 0 cc 1*j.i Ix~ > A a, 0 r- w-0 4 1 En 00U...r AD-AL1A 518 DELAWARE UN IV NEWARK DEPT OF CIVIL ENGINEERING F/G 8/ 3 NUMER ICAL MODELI NG OF THE NEARS" ORE REGION U) JUN 82 j T KIRBY, R A OALR

Analog detection for cavity lifetime spectroscopy

DOEpatents

Zare, Richard N.; Harb, Charles C.; Paldus, Barbara A.; Spence, Thomas G.

2001-05-15

An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

Analog detection for cavity lifetime spectroscopy

DOEpatents

Zare, Richard N.; Harb, Charles C.; Paldus, Barbara A.; Spence, Thomas G.

2003-01-01

An analog detection system for determining a ring-down rate or decay rate 1/.tau. of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

Characterization of edible coatings consisting of pea starch, whey protein isolate, and Carnauba wax and their effects on oil rancidity and sensory properties of walnuts and pine nuts.

PubMed

Mehyar, Ghadeer F; Al-Ismail, Khalid; Han, Jung H; Chee, Grace W

2012-02-01

Edible coatings made of whey protein isolate (WPI), pea starch (PS), and their combinations with carnauba wax (CW) were prepared and characterized. WPI combined with CW formed stable emulsion while PS with CW formed unstable emulsion and both formulations produced non-homogeneous films. Addition of PS to WPI: CW combination at the ratio of 1:1:1, respectively, resulted in stable emulsion and homogenous films. The emulsion PS: WPI: CW (1:1:2) was stable and formed a continuous film but had less homogenous droplets size distribution when compared to 1:1:1 film. Combined films had a reduced tensile strength and elongation compared to single component films. WPI : CW (1:1) films had higher elastic modulus than the WPI films, but the modulus reduced by the addition of PS. All the coating formulations were effective in preventing oxidative and hydrolytic rancidity of walnuts and pine nuts stored at 25 °C throughout the storage (12 d) but were less effective at 50 °C. Increasing the concentration of CW from 1:1:1 to 1:1:2 in PS: WPI: CW formulation did not contribute in further prevention of oil rancidity at 25 °C. Using of PS: WPI: CW (1:1:1) coating on both nuts significantly (P < 0.05) improved their smoothness and taste but the PS: WPI: CW (1:1:2) coatings imparted unacceptable yellowish color on walnuts. Edible coating of walnuts and pine nuts by whey protein isolate, pea starch, and carnauba wax reduced the oxidative and hydrolytic rancidity of the nuts and improved sensory characteristics. © 2012 Institute of Food Technologists®

Anaerobic digestion of cheese whey: Energetic and nutritional potential for the dairy sector in developing countries.

PubMed

Escalante, H; Castro, L; Amaya, M P; Jaimes, L; Jaimes-Estévez, J

2018-01-01

Cheese whey (CW) is the main waste generated in the cheesemaking process and has high organic matter content and acidity. Therefore, CW disposal is a challenge for small to medium enterprises (SMEs) in the dairy industry that do not have any type of treatment plant. Anaerobic digestion (AD) is an attractive process for solving this problem. The aim of this research was to determine the biomethane and struvite precipitation potentials of CW from four dairy SMEs. First, changes in CW properties (organic matter and pH) were evaluated. Second, biomethane and struvite potentials were assessed using cattle slurry as inoculum. The organic matter in CW varied from 40 to 65gVS/kg, 65 to 140g COD/L, and 2 to 10g/L for VFAs depending on the sampling time and type of sample. The pH of the CW samples ranged from 3 to 6.5. In the anaerobic biodegradability analysis, methane yields reached 0.51 to 0.60L CH 4 /g VS added , which represented electrical and caloric potentials of 54 and 108kWh/m 3 for CW, respectively. Organic matter removal in all experiments was above 83%. Moreover, anaerobic digestates presented NH 4 + /PO 4 3- molar ratios between 2.6 and 4.0, which are adequate for struvite precipitation with potential production of 8.5-10.4g struvite/L CW. Finally, the use of biogas as energetic supplement and struvite as soil fertilizer, represents economics saves of US$ 6.91/m 3 CW and US$ 5.75/m 3 CW in therms of electricity and fertilizer use, respectively. The energetic, agricultural and economic potentials, evidence that AD process is a feasible alternative for cheese whey treatment. Copyright © 2017. Published by Elsevier Ltd.

Astronaut mass measurement using linear acceleration method and the effect of body non-rigidity

NASA Astrophysics Data System (ADS)

Yan, Hui; Li, LuMing; Hu, ChunHua; Chen, Hao; Hao, HongWei

2011-04-01

Astronaut's body mass is an essential factor of health monitoring in space. The latest mass measurement device for the International Space Station (ISS) has employed a linear acceleration method. The principle of this method is that the device generates a constant pulling force, and the astronaut is accelerated on a parallelogram motion guide which rotates at a large radius to achieve a nearly linear trajectory. The acceleration is calculated by regression analysis of the displacement versus time trajectory and the body mass is calculated by using the formula m= F/ a. However, in actual flight, the device is instable that the deviation between runs could be 6-7 kg. This paper considers the body non-rigidity as the major cause of error and instability and analyzes the effects of body non-rigidity from different aspects. Body non-rigidity makes the acceleration of the center of mass (C.M.) oscillate and fall behind the point where force is applied. Actual acceleration curves showed that the overall effect of body non-rigidity is an oscillation at about 7 Hz and a deviation of about 25%. To enhance body rigidity, better body restraints were introduced and a prototype based on linear acceleration method was built. Measurement experiment was carried out on ground on an air table. Three human subjects weighing 60-70 kg were measured. The average variance was 0.04 kg and the average measurement error was 0.4%. This study will provide reference for future development of China's own mass measurement device.

Estimation of Relative Economic Weights of Hanwoo Carcass Traits Based on Carcass Market Price

PubMed Central

Choy, Yun Ho; Park, Byoung Ho; Choi, Tae Jung; Choi, Jae Gwan; Cho, Kwang Hyun; Lee, Seung Soo; Choi, You Lim; Koh, Kyung Chul; Kim, Hyo Sun

2012-01-01

The objective of this study was to estimate economic weights of Hanwoo carcass traits that can be used to build economic selection indexes for selection of seedstocks. Data from carcass measures for determining beef yield and quality grades were collected and provided by the Korean Institute for Animal Products Quality Evaluation (KAPE). Out of 1,556,971 records, 476,430 records collected from 13 abattoirs from 2008 to 2010 after deletion of outlying observations were used to estimate relative economic weights of bid price per kg carcass weight on cold carcass weight (CW), eye muscle area (EMA), backfat thickness (BF) and marbling score (MS) and the phenotypic relationships among component traits. Price of carcass tended to increase linearly as yield grades or quality grades, in marginal or in combination, increased. Partial regression coefficients for MS, EMA, BF, and for CW in original scales were +948.5 won/score, +27.3 won/cm2, −95.2 won/mm and +7.3 won/kg when all three sex categories were taken into account. Among four grade determining traits, relative economic weight of MS was the greatest. Variations in partial regression coefficients by sex categories were great but the trends in relative weights for each carcass measures were similar. Relative economic weights of four traits in integer values when standardized measures were fit into covariance model were +4:+1:−1:+1 for MS:EMA:BF:CW. Further research is required to account for the cost of production per unit carcass weight or per unit production under different economic situations. PMID:25049531

Reinventing the Accelerator for the High Energy Frontier

ScienceCinema

Rosenzweig, James [UCLA, Los Angeles, California, United States

2017-12-09

The history of discovery in high-energy physics has been intimately connected with progress in methods of accelerating particles for the past 75 years. This remains true today, as the post-LHC era in particle physics will require significant innovation and investment in a superconducting linear collider. The choice of the linear collider as the next-generation discovery machine, and the selection of superconducting technology has rather suddenly thrown promising competing techniques -- such as very large hadron colliders, muon colliders, and high-field, high frequency linear colliders -- into the background. We discuss the state of such conventional options, and the likelihood of their eventual success. We then follow with a much longer view: a survey of a new, burgeoning frontier in high energy accelerators, where intense lasers, charged particle beams, and plasmas are all combined in a cross-disciplinary effort to reinvent the accelerator from its fundamental principles on up.

Recording the synchrotron radiation by a picosecond streak camera for bunch diagnostics in cyclic accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vereshchagin, A K; Vorob'ev, N S; Gornostaev, P B

2016-02-28

A PS-1/S1 picosecond streak camera with a linear sweep is used to measure temporal characteristics of synchrotron radiation pulses on a damping ring (DR) at the Budker Institute of Nuclear Physics (BINP) of the Siberian Branch of the Russian Academy of Sciences (Novosibirsk). The data obtained allow a conclusion as to the formation processes of electron bunches and their 'quality' in the DR after injection from the linear accelerator. The expediency of employing the streak camera as a part of an optical diagnostic accelerator complex for adjusting the injection from a linear accelerator is shown. Discussed is the issue ofmore » designing a new-generation dissector with a time resolution up to a few picoseconds, which would allow implementation of a continuous bunch monitoring in the DR during mutual work with the electron-positron colliders at the BINP. (acoustooptics)« less

Initial Human Response to Nuclear Radiation

DTIC Science & Technology

1982-04-01

radiation from a linear accelerator . Victim A , age 31, received a dose of 100 rads; victim B, age 29... The radiation has always been in the million-electron- volt range, usually from a cobalt 60 source but sometimes using linear accelerators prouucing up...more recent medical experience, Appendix B presents comments by a radiation oncologist on the

Cocos nucifera L. water improves reproductive indices in Wistar Rats.

PubMed

Kunle-Alabi, O T; Akindele, O O; Oyovwi, M O; Duro-Ladipo, M A; Raji, Y

2014-12-01

This study explored the effects of Cocos nucifera L. water (CW) on the hypothalamo-pituitary-gonadal axis (HPG) and fertility in Wistar rats. Adult male and female Wistar rats were treated orally as follows; Study 1: Group 1: control (distilled water), group 2: 20 ml/kg corn oil (danazol vehicle), group 3: 20 ml/kg CW, group 4: 40 ml/kg CW, group 5: danazol, group 6: danazol + 20 ml/kg CW and group 7: danazol + 40 ml/kg CW. 200 mg/ kg danazol was administered. Serum levels of LH, FSH, estradiol and testosterone; gonadal weights and sperm indices were assessed. Study 2: Group 1: control (distilled water), group 2: 20 ml/kg CW, group 3: 40 ml/kg CW for 6 and 2 weeks prior to mating in male and female rats respectively. Significant (p < 0.05) increases in estradiol concentration were observed in groups 3, 4, 6 and 7. Significant reductions in LH, FSH, estradiol and testosterone levels were observed in group 5 which were ameliorated in groups 6 and 7. Males showed significant increases in sperm count and motility in groups 3, 4, 6 and 7, and reductions in these variables along with viability in group 5. CW pre-treatment increased fecundity index and proportion of female pups from dams, while the pups from sires showed higher birth weights. CW acts on the HPG to positively influence reproductive function in both males and females and may aid in maternal preconception sex selection of female offspring.

Indirectly sensing accelerator beam currents for limiting maximum beam current magnitude

DOEpatents

Bogaty, J.M.; Clifft, B.E.; Bollinger, L.M.

1995-08-08

A beam current limiter is disclosed for sensing and limiting the beam current in a particle accelerator, such as a cyclotron or linear accelerator, used in scientific research and medical treatment. A pair of independently operable capacitive electrodes sense the passage of charged particle bunches to develop an RF signal indicative of the beam current magnitude produced at the output of a bunched beam accelerator. The RF signal produced by each sensing electrode is converted to a variable DC voltage indicative of the beam current magnitude. The variable DC voltages thus developed are compared to each other to verify proper system function and are further compared to known references to detect beam currents in excess of pre-established limits. In the event of a system malfunction, or if the detected beam current exceeds pre-established limits, the beam current limiter automatically inhibits further accelerator operation. A high Q tank circuit associated with each sensing electrode provides a narrow system bandwidth to reduce noise and enhance dynamic range. System linearity is provided by injecting, into each sensing electrode, an RF signal that is offset from the bunching frequency by a pre-determined beat frequency to ensure that subsequent rectifying diodes operate in a linear response region. The system thus provides a large dynamic range in combination with good linearity. 6 figs.

Indirectly sensing accelerator beam currents for limiting maximum beam current magnitude

DOEpatents

Bogaty, John M.; Clifft, Benny E.; Bollinger, Lowell M.

1995-01-01

A beam current limiter for sensing and limiting the beam current in a particle accelerator, such as a cyclotron or linear accelerator, used in scientific research and medical treatment. A pair of independently operable capacitive electrodes sense the passage of charged particle bunches to develop an RF signal indicative of the beam current magnitude produced at the output of a bunched beam accelerator. The RF signal produced by each sensing electrode is converted to a variable DC voltage indicative of the beam current magnitude. The variable DC voltages thus developed are compared to each other to verify proper system function and are further compared to known references to detect beam currents in excess of pre-established limits. In the event of a system malfunction, or if the detected beam current exceeds pre-established limits, the beam current limiter automatically inhibits further accelerator operation. A high Q tank circuit associated with each sensing electrode provides a narrow system bandwidth to reduce noise and enhance dynamic range. System linearity is provided by injecting, into each sensing electrode, an RF signal that is offset from the bunching frequency by a pre-determined beat frequency to ensure that subsequent rectifying diodes operate in a linear response region. The system thus provides a large dynamic range in combination with good linearity.

Distributed coupling high efficiency linear accelerator

DOEpatents

Tantawi, Sami G.; Neilson, Jeffrey

2016-07-19

A microwave circuit for a linear accelerator includes multiple monolithic metallic cell plates stacked upon each other so that the beam axis passes vertically through a central acceleration cavity of each plate. Each plate has a directional coupler with coupling arms. A first coupling slot couples the directional coupler to an adjacent directional coupler of an adjacent cell plate, and a second coupling slot couples the directional coupler to the central acceleration cavity. Each directional coupler also has an iris protrusion spaced from corners joining the arms, a convex rounded corner at a first corner joining the arms, and a corner protrusion at a second corner joining the arms.

Free electron laser

DOEpatents

Villa, Francesco

1990-01-01

A high gain, single-pass free electron laser formed of a high brilliance electron injector source, a linear accelerator which imparts high energy to the electron beam, and an undulator capable of extremely high magnetic fields, yet with a very short period. The electron injector source is the first stage (gap) of the linear accelerator or a radial line transformer driven by fast circular switch. The linear accelerator is formed of a plurality of accelerating gaps arranged in series. These gaps are energized in sequence by releasing a single pulse of energy which propagates simultaneously along a plurality of transmission lines, each of which feeds the gaps. The transmission lines are graduated in length so that pulse power is present at each gap as the accelerated electrons pass therethrough. The transmission lines for each gap are open circuited at their ends. The undualtor has a structure similar to the accelerator, except that the transmission lines for each gap are substantially short circuited at their ends, thus converting the electric field into magnetic field. A small amount of resistance is retained in order to generate a small electric field for replenishing the electron bunch with the energy lost as it traverses through the undulator structure.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Henan, E-mail: wuhenanby@163.com; Chen, Qiufan; Yue, Xiaoqing

The Lie conformal algebra of loop Virasoro algebra, denoted by CW, is introduced in this paper. Explicitly, CW is a Lie conformal algebra with C[∂]-basis (L{sub i} | i∈Z) and λ-brackets [L{sub i} {sub λ} L{sub j}] = (−∂−2λ)L{sub i+j}. Then conformal derivations of CW are determined. Finally, rank one conformal modules and Z-graded free intermediate series modules over CW are classified.

Anatomical Variations of the Circulus Arteriosus in Cadaveric Human Brains

PubMed Central

Gunnal, S. A.; Farooqui, M. S.; Wabale, R. N.

2014-01-01

Objective. Circulus arteriosus/circle of Willis (CW) is a polygonal anastomotic channel at the base of the brain which unites the internal carotid and vertebrobasilar system. It maintains the steady and constant supply to the brain. The variations of CW are seen often. The Aim of the present work is to find out the percentage of normal pattern of CW, and the frequency of variations of the CW and to study the morphological and morphometric aspects of all components of CW. Methods. Circulus arteriosus of 150 formalin preserved brains were dissected. Dimensions of all the components forming circles were measured. Variations of all the segments were noted and well photographed. The variations such as aplasia, hypoplasia, duplication, fenestrations, and difference in dimensions with opposite segments were noted. The data collected in the study was analyzed. Results. Twenty-one different types of CW were found in the present study. Normal and complete CW was found in 60%. CW with gross morphological variations was seen in 40%. Maximum variations were seen in the PCoA followed by the ACoA in 50% and 40%, respectively. Conclusion. As it confirms high percentage of variations, all surgical interventions should be preceded by angiography. Awareness of these anatomical variations is important in neurovascular procedures. PMID:24891951

Phytoremediation of domestic wastewaters in free water surface constructed wetlands using Azolla pinnata.

PubMed

Akinbile, Christopher O; Ogunrinde, Temitope A; Che Bt Man, Hasfalina; Aziz, Hamidi Abdul

2016-01-01

Two constructed wetlands, one with Azolla pinnata plant (CW1) and the other without (CW2) for treating domestic wastewaters were developed. Fifteen water parameters which include: Dissolved Oxygen (DO), Biochemical Oxygen Demand (BOD5), Chemical Oxygen Demand (COD), Total Suspended Solid (TSS), Total Phosphorus (TP), Total Nitrogen (TN), Ammoniacal Nitrogen (NH3N), Turbidity, pH, Electrical Conductivity (EC), Iron (Fe), Magnesium (Mg), Manganese (Mn), and heavy metals such as Lead (Pb) and Zinc (Zn) were analyzed using standard laboratory procedures. The experiments were conducted in two (dry and wet) seasons simultaneously. Results showed considerable reductions in all parameters and metals including Zn in CW1 compared with CW2 in the two seasons considered while Pb and Mn were not detected throughout the study. Zn concentration levels reduced significantly in both seasons just as removal efficiencies of 70.03% and 64.51% were recorded for CW1 while 35.17% and 33.45% were recorded for CW2 in both seasons. There were no significant differences in the removal efficiencies of Fe in both seasons as 99.55%, 59.09%, 88.89%, and 53.56% were recorded in CW1 and CW2 respectively. Azolla pinnata has proved effective in domestic wastewater phytoremediation studies.

TU-H-BRA-01: The Physics of High Power Radiofrequency Isolation in a Novel Compact Linear Accelerator Based MRI Guided Radiation Therapy System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamb, J; Low, D; Mutic, S

Purpose: To develop a method for isolating the radiofrequency waves emanating from linear accelerator components from the magnetic resonance imaging (MRI) system of an integrated MRI-linac. Methods: An MRI-guided radiation therapy system has been designed that integrates a linear accelerator with simultaneous MR imaging. The radiofrequency waves created by the accelerating process would degrade MR image quality, so a method for containing the radiofrequency waves and isolating the MR imager from them was developed. The linear accelerator radiofrequency modulator was placed outside the room, so a filter was designed to eliminate the radiofrequency corresponding to the proton Larmour frequency ofmore » 14.7 MHz. Placing the radiofrequency emitting components in a typical Faraday cage would have reduced the radiofrequency emissions, but the design would be susceptible to small gaps in the shield due to the efficiency of the Faraday cage reflecting internal radiofrequency emissions. To reduce internal radiofrequency reflections, the Faraday cage was lined with carbon fiber sheets. Carbon fiber has the property of attenuating the radiofrequency energy so that the overall radiofrequency field inside the Faraday cage is reduced, decreasing any radiofrequency energy emitted from small gaps in the cage walls. Results: Within a 1.2 MHz band centered on the Larmor frequency, the radiofrequency (RF) leakage from the Faraday cage was measured to be −90 dB with no RF on, −40 dB with the RF on and no shield, returning to −90 dB with the RF on and shields in place. The radiofrequency filter attenuated the linear accelerator modulator emissions in the 14.7 MHz band by 70 dB. Conclusions: One of the major challenges in designing a compact linear accelerator based MRI-guided radiation therapy system, that of isolating the high power RF system from the MRI, has been solved. The measured radiofrequency emissions are sufficiently small to enable system integration. This research was funded by ViewRay, Inc., Oakwood, OH.« less

TU-H-BRA-02: The Physics of Magnetic Field Isolation in a Novel Compact Linear Accelerator Based MRI-Guided Radiation Therapy System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Low, D; Mutic, S; Shvartsman, S

Purpose: To develop a method for isolating the MRI magnetic field from field-sensitive linear accelerator components at distances close to isocenter. Methods: A MRI-guided radiation therapy system has been designed that integrates a linear accelerator with simultaneous MR imaging. In order to accomplish this, the magnetron, port circulator, radiofrequency waveguide, gun driver, and linear accelerator needed to be placed in locations with low magnetic fields. The system was also required to be compact, so moving these components far from the main magnetic field and isocenter was not an option. The magnetic field sensitive components (exclusive of the waveguide) were placedmore » in coaxial steel sleeves that were electrically and mechanically isolated and whose thickness and placement were optimized using E&M modeling software. Six sets of sleeves were placed 60° apart, 85 cm from isocenter. The Faraday effect occurs when the direction of propagation is parallel to the magnetic RF field component, rotating the RF polarization, subsequently diminishing RF power. The Faraday effect was avoided by orienting the waveguides such that the magnetic field RF component was parallel to the magnetic field. Results: The magnetic field within the shields was measured to be less than 40 Gauss, significantly below the amount needed for the magnetron and port circulator. Additional mu-metal was employed to reduce the magnetic field at the linear accelerator to less than 1 Gauss. The orientation of the RF waveguides allowed the RT transport with minimal loss and reflection. Conclusion: One of the major challenges in designing a compact linear accelerator based MRI-guided radiation therapy system, that of creating low magnetic field environments for the magnetic-field sensitive components, has been solved. The measured magnetic fields are sufficiently small to enable system integration. This work supported by ViewRay, Inc.« less

Detection of linear ego-acceleration from optic flow.

PubMed

Festl, Freya; Recktenwald, Fabian; Yuan, Chunrong; Mallot, Hanspeter A

2012-07-20

Human observers are able to estimate various ego-motion parameters from optic flow, including rotation, translational heading, time-to-collision (TTC), time-to-passage (TTP), etc. The perception of linear ego-acceleration or deceleration, i.e., changes of translational velocity, is less well understood. While time-to-passage experiments indicate that ego-acceleration is neglected, subjects are able to keep their (perceived) speed constant under changing conditions, indicating that some sense of ego-acceleration or velocity change must be present. In this paper, we analyze the relation of ego-acceleration estimates and geometrical parameters of the environment using simulated flights through cylindrical and conic (narrowing or widening) corridors. Theoretical analysis shows that a logarithmic ego-acceleration parameter, called the acceleration rate ρ, can be calculated from retinal acceleration measurements. This parameter is independent of the geometrical layout of the scene; if veridical ego-motion is known at some instant in time, acceleration rate allows updating of ego-motion without further depth-velocity calibration. Results indicate, however, that subjects systematically confuse ego-acceleration with corridor narrowing and ego-deceleration with corridor widening, while veridically judging ego-acceleration in straight corridors. We conclude that judgments of ego-acceleration are based on first-order retinal flow and do not make use of acceleration rate or retinal acceleration.

Enhanced chemical weapon warning via sensor fusion

NASA Astrophysics Data System (ADS)

Flaherty, Michael; Pritchett, Daniel; Cothren, Brian; Schwaiger, James

2011-05-01

Torch Technologies Inc., is actively involved in chemical sensor networking and data fusion via multi-year efforts with Dugway Proving Ground (DPG) and the Defense Threat Reduction Agency (DTRA). The objective of these efforts is to develop innovative concepts and advanced algorithms that enhance our national Chemical Warfare (CW) test and warning capabilities via the fusion of traditional and non-traditional CW sensor data. Under Phase I, II, and III Small Business Innovative Research (SBIR) contracts with DPG, Torch developed the Advanced Chemical Release Evaluation System (ACRES) software to support non real-time CW sensor data fusion. Under Phase I and II SBIRs with DTRA in conjunction with the Edgewood Chemical Biological Center (ECBC), Torch is using the DPG ACRES CW sensor data fuser as a framework from which to develop the Cloud state Estimation in a Networked Sensor Environment (CENSE) data fusion system. Torch is currently developing CENSE to implement and test innovative real-time sensor network based data fusion concepts using CW and non-CW ancillary sensor data to improve CW warning and detection in tactical scenarios.

Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.

PubMed

Fan, Q R; Long, E O; Wiley, D C

2001-05-01

Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal. Most of the amino acids that differ between human and chimpanzee KIRs with HLA-C specificities form solvent-accessible clusters outside the KIR-HLA interface, which suggests undiscovered interactions by KIRs.

ALMA data suggest the presence of spiral structure in the inner wind of CW Leonis

NASA Astrophysics Data System (ADS)

Decin, L.; Richards, A. M. S.; Neufeld, D.; Steffen, W.; Melnick, G.; Lombaert, R.

2015-02-01

Context. Evolved low-mass stars lose a significant fraction of their mass through stellar winds. While the overall morphology of the stellar wind structure during the asymptotic giant branch (AGB) phase is thought to be roughly spherically symmetric, the morphology changes dramatically during the post-AGB and planetary nebula phase, during which bipolar and multi-polar structures are often observed. Aims: We aim to study the inner wind structure of the closest well-known AGB star CW Leo. Different diagnostics probing different geometrical scales have implied a non-homogeneous mass-loss process for this star: dust clumps are observed at milli-arcsec scale, a bipolar structure is seen at arcsecond-scale, and multi-concentric shells are detected beyond 1''. Methods: We present the first ALMA Cycle 0 band 9 data around 650 GHz (450 μm) tracing the inner wind of CW Leo. The full-resolution data have a spatial resolution of 0.̋42 × 0.̋24, allowing us to study the morpho-kinematical structure of CW Leo within ~6''. Results: We have detected 25 molecular emission lines in four spectral windows. The emission of all but one line is spatially resolved. The dust and molecular lines are centered around the continuum peak position, which is assumed to be dominated by stellar emission. The dust emission has an asymmetric distribution with a central peak flux density of ~2 Jy. The molecular emission lines trace different regions in the wind acceleration region and imply that the wind velocity increases rapidly from about 5 R⋆, almost reaching the terminal velocity at ~11 R⋆. The images prove that vibrational lines are excited close to the stellar surface and that SiO is a parent molecule. The channel maps for the brighter lines show a complex structure; specifically, for the 13CO J = 6-5 line, different arcs are detected within the first few arcseconds. The curved structure in the position-velocity (PV) map of the 13CO J = 6-5 line can be explained by a spiral structure in the inner wind of CW Leo, probably induced by a binary companion. From modelling the ALMA data, we deduce that the potential orbital axis for the binary system lies at a position angle of ~10-20° to the north-east and that the spiral structure is seen almost edge-on. We infer an orbital period of 55 yr and a binary separation of 25 au (or ~8.2 R⋆). We tentatively estimate that the companion is an unevolved low-mass main-sequence star. Conclusions: A scenario of a binary-induced spiral shell can explain the correlated structure seen in the ALMA PV images of CW Leo. Moreover, this scenario can also explain many other observational signatures seen at different spatial scales and in different wavelength regions, such as the bipolar structure and the almost concentric shells. ALMA data hence for the first time provide the crucial kinematical link between the dust clumps seen at milli-arcsecond scale and the almost concentric arcs seen at arcsecond scale. Appendix A is available in electronic form at http://www.aanda.org

Development of sub-100 femtosecond timing and synchronization system

NASA Astrophysics Data System (ADS)

Lin, Zhenyang; Du, Yingchao; Yang, Jin; Xu, Yilun; Yan, Lixin; Huang, Wenhui; Tang, Chuanxiang; Huang, Gang; Du, Qiang; Doolittle, Lawrence; Wilcox, Russell; Byrd, John

2018-01-01

The precise timing and synchronization system is an essential part for the ultra-fast electron and X-ray sources based on the photocathode injector where strict synchronization among RF, laser, and beams are required. In this paper, we present an integrated sub-100 femtosecond timing and synchronization system developed and demonstrated recently in Tsinghua University based on the collaboration with Lawrence Berkeley National Lab. The timing and synchronization system includes the fiber-based CW carrier phase reference distribution system for delivering stabilized RF phase reference to multiple receiver clients, the Low Level RF (LLRF) control system to monitor and generate the phase and amplitude controllable pulse RF signal, and the laser-RF synchronization system for high precision synchronization between optical and RF signals. Each subsystem is characterized by its blocking structure and is also expansible. A novel asymmetric calibration sideband signal method was proposed for eliminating the non-linear distortion in the optical synchronization process. According to offline and online tests, the system can deliver a stable signal to each client and suppress the drift and jitter of the RF signal for the accelerator and the laser oscillator to less than 100 fs RMS (˜0.1° in 2856 MHz frequency). Moreover, a demo system with a LLRF client and a laser-RF synchronization client is deployed and operated successfully at the Tsinghua Thomson scattering X-ray source. The beam-based jitter measurement experiments have been conducted to evaluate the overall performance of the system, and the jitter sources are discussed.

Development of sub-100 femtosecond timing and synchronization system.

PubMed

Lin, Zhenyang; Du, Yingchao; Yang, Jin; Xu, Yilun; Yan, Lixin; Huang, Wenhui; Tang, Chuanxiang; Huang, Gang; Du, Qiang; Doolittle, Lawrence; Wilcox, Russell; Byrd, John

2018-01-01

The precise timing and synchronization system is an essential part for the ultra-fast electron and X-ray sources based on the photocathode injector where strict synchronization among RF, laser, and beams are required. In this paper, we present an integrated sub-100 femtosecond timing and synchronization system developed and demonstrated recently in Tsinghua University based on the collaboration with Lawrence Berkeley National Lab. The timing and synchronization system includes the fiber-based CW carrier phase reference distribution system for delivering stabilized RF phase reference to multiple receiver clients, the Low Level RF (LLRF) control system to monitor and generate the phase and amplitude controllable pulse RF signal, and the laser-RF synchronization system for high precision synchronization between optical and RF signals. Each subsystem is characterized by its blocking structure and is also expansible. A novel asymmetric calibration sideband signal method was proposed for eliminating the non-linear distortion in the optical synchronization process. According to offline and online tests, the system can deliver a stable signal to each client and suppress the drift and jitter of the RF signal for the accelerator and the laser oscillator to less than 100 fs RMS (∼0.1° in 2856 MHz frequency). Moreover, a demo system with a LLRF client and a laser-RF synchronization client is deployed and operated successfully at the Tsinghua Thomson scattering X-ray source. The beam-based jitter measurement experiments have been conducted to evaluate the overall performance of the system, and the jitter sources are discussed.

Heating and Acceleration of Charged Particles by Weakly Compressible Magnetohydrodynamic Turbulence

NASA Astrophysics Data System (ADS)

Lynn, Jacob William

We investigate the interaction between low-frequency magnetohydrodynamic (MHD) turbulence and a distribution of charged particles. Understanding this physics is central to understanding the heating of the solar wind, as well as the heating and acceleration of other collisionless plasmas. Our central method is to simulate weakly compressible MHD turbulence using the Athena code, along with a distribution of test particles which feel the electromagnetic fields of the turbulence. We also construct analytic models of transit-time damping (TTD), which results from the mirror force caused by compressible (fast or slow) MHD waves. Standard linear-theory models in the literature require an exact resonance between particle and wave velocities to accelerate particles. The models developed in this thesis go beyond standard linear theory to account for the fact that wave-particle interactions decorrelate over a short time, which allows particles with velocities off resonance to undergo acceleration and velocity diffusion. We use the test particle simulation results to calibrate and distinguish between different models for this velocity diffusion. Test particle heating is larger than the linear theory prediction, due to continued acceleration of particles with velocities off-resonance. We also include an artificial pitch-angle scattering to the test particle motion, representing the effect of high-frequency waves or velocity-space instabilities. For low scattering rates, we find that the scattering enforces isotropy and enhances heating by a modest factor. For much higher scattering rates, the acceleration is instead due to a non-resonant effect, as particles "frozen" into the fluid adiabatically gain and lose energy as eddies expand and contract. Lastly, we generalize our calculations to allow for relativistic test particles. Linear theory predicts that relativistic particles with velocities much higher than the speed of waves comprising the turbulence would undergo no acceleration; resonance-broadening modifies this conclusion and allows for a continued Fermi-like acceleration process. This may affect the observed spectra of black hole accretion disks by accelerating relativistic particles into a quasi-powerlaw tail.

Development work for a superconducting linear collider

NASA Technical Reports Server (NTRS)

Matheisen, Axel

1995-01-01

For future linear e(+)e(-) colliders in the TeV range several alternatives are under discussion. The TESLA approach is based on the advantages of superconductivity. High Q values of the accelerator structures give high efficiency for converting RF power into beam power. A low resonance frequency for the RF structures can be chosen to obtain a large number of electrons (positrons) per bunch. For a given luminosity the beam dimensions can be chosen conservatively which leads to relaxed beam emittance and tolerances at the final focus. Each individual superconducting accelerator component (resonator cavity) of this linear collider has to deliver an energy gain of 25 MeV/m to the beam. Today s.c. resonators are in use at CEBAF/USA, at DESY/Germany, Darmstadt/Germany KEK/Japan and CERN/Geneva. They show acceleration gradients between 5 MV/m and 10 MV/m. Encouraging experiments at CEA Saclay and Cornell University showed acceleration gradients of 20 MV/m and 25 MV/m in single and multicell structures. In an activity centered at DESY in Hamburg/Germany the TESLA collaboration is constructing a 500 MeV superconducting accelerator test facility (TTF) to demonstrate that a linear collider based on this technique can be built in a cost effective manner and that the necessary acceleration gradients of more than 15 MeV/m can be reached reproducibly. The test facility built at DESY covers an area of 3.000 m2 and is divided into 3 major activity areas: (1) The testlinac, where the performance ofthe modular components with an electron beam passing the 40 m long acceleration section can be demonstrated. (2) The test area, where all individual resonators are tested before installation into a module. (3) The preparation and assembly area, where assembly of cavities and modules take place. We report here on the design work to reach a reduction of costs compared to actual existing superconducting accelerator structures and on the facility set up to reach high acceleration gradients in a reproducible way.

Vestibular afferent responses to linear accelerations in the alert squirrel monkey

NASA Technical Reports Server (NTRS)

Somps, Christopher J.; Schor, Robert H.; Tomko, David L.

1994-01-01

The spontaneous activity of 40 otolith afferents and 44 canal afferents was recorded in 4 alert, intact squirrel monkeys. Polarization vectors and response properties of otolith afferents were determined during static re-orientations relative to gravity and during Earth-horizontal, sinusoidal, linear oscillations. Canal afferents were tested for sensitivity to linear accelerations. For regular otolith afferents, a significant correlation between upright discharge rate and sensitivity to dynamic acceleration in the horizontal plane was observed. This correlation was not present in irregular units. The sensitivity of otolith afferents to both static tilts and dynamic linear acceleration was much greater in irregularly discharging units than in regularly discharging units. The spontaneous activity and static and dynamic response properties of regularly discharging otolith afferents were similar to those reported in barbiturate-anesthetized squirrel monkeys. Irregular afferents also had similar dynamic response properties when compared to anesthetized monkeys. However, this sample of irregular afferents in alert animals had higher resting discharge rates and greater sensitivity to static tilts. The majority of otolith polarization vectors were oriented near the horizontal in the plane of the utricular maculae; however, directions of maximum sensitivity were different during dynamic and static testing. Canal afferents were not sensitive to static tilts or linear oscillations of the head.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartolac, S; Letourneau, D; University of Toronto, Toronto, Ontario

Purpose: Application of process control theory in quality assurance programs promises to allow earlier identification of problems and potentially better quality in delivery than traditional paradigms based primarily on tolerances and action levels. The purpose of this project was to characterize underlying seasonal variations in linear accelerator output that can be used to improve performance or trigger preemptive maintenance. Methods: Review of runtime plots of daily (6 MV) output data acquired using in house ion chamber based devices over three years and for fifteen linear accelerators of varying make and model were evaluated. Shifts in output due to known interventionsmore » with the machines were subtracted from the data to model an uncorrected scenario for each linear accelerator. Observable linear trends were also removed from the data prior to evaluation of periodic variations. Results: Runtime plots of output revealed sinusoidal, seasonal variations that were consistent across all units, irrespective of manufacturer, model or age of machine. The average amplitude of the variation was on the order of 1%. Peak and minimum variations were found to correspond to early April and September, respectively. Approximately 48% of output adjustments made over the period examined were potentially avoidable if baseline levels had corresponded to the mean output, rather than to points near a peak or valley. Linear trends were observed for three of the fifteen units, with annual increases in output ranging from 2–3%. Conclusion: Characterization of cyclical seasonal trends allows for better separation of potentially innate accelerator behaviour from other behaviours (e.g. linear trends) that may be better described as true out of control states (i.e. non-stochastic deviations from otherwise expected behavior) and could indicate service requirements. Results also pointed to an optimal setpoint for accelerators such that output of machines is maintained within set tolerances and interventions are required less frequently.« less

Spatiotemporal processing of linear acceleration: primary afferent and central vestibular neuron responses

NASA Technical Reports Server (NTRS)

Angelaki, D. E.; Dickman, J. D.

2000-01-01

Spatiotemporal convergence and two-dimensional (2-D) neural tuning have been proposed as a major neural mechanism in the signal processing of linear acceleration. To examine this hypothesis, we studied the firing properties of primary otolith afferents and central otolith neurons that respond exclusively to horizontal linear accelerations of the head (0.16-10 Hz) in alert rhesus monkeys. Unlike primary afferents, the majority of central otolith neurons exhibited 2-D spatial tuning to linear acceleration. As a result, central otolith dynamics vary as a function of movement direction. During movement along the maximum sensitivity direction, the dynamics of all central otolith neurons differed significantly from those observed for the primary afferent population. Specifically at low frequencies (

Exploring the feasibility of focusing CW light through a scattering medium into closely spaced twin peaks via numerical solutions of Maxwell’s equations

NASA Astrophysics Data System (ADS)

Tseng, Snow H.; Chang, Shih-Hui

2018-04-01

Here we present a numerical simulation to analyze the effect of scattering on focusing light into closely-spaced twin peaks. The pseudospectral time-domain (PSTD) is implemented to model continuous-wave (CW) light propagation through a scattering medium. Simulations show that CW light can propagate through a scattering medium and focus into closely-spaced twin peaks. CW light of various wavelengths focusing into twin peaks with sub-diffraction spacing is simulated. In advance, light propagation through scattering media of various number densities is simulated to decipher the dependence of CW light focusing phenomenon on the scattering medium. The reported simulations demonstrate the feasibility of focusing CW light into twin peaks with sub-diffraction dimensions. More importantly, based upon numerical solutions of Maxwell’s equations, research findings show that the sub-diffraction focusing phenomenon can be achieved with scarce or densely-packed scattering media.

Symposium on electron linear accelerators in honor of Richard B. Neal's 80th birthday: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Siemann, R.H.

The papers presented at the conference are: (1) the construction of SLAC and the role of R.B. Neal; (2) symposium speech; (3) lessons learned from the SLC; (4) alternate approaches to future electron-positron linear colliders; (5) the NLC technical program; (6) advanced electron linacs; (7) medical uses of linear accelerators; (8) linac-based, intense, coherent X-ray source using self-amplified spontaneous emission. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

Removal of selected emerging PPCP compounds using greater duckweed (Spirodela polyrhiza) based lab-scale free water constructed wetland.

PubMed

Li, Jianan; Zhou, Qizhi; Campos, Luiza C

2017-12-01

Greater duckweed (Spirodela polyrhiza) based lab-scale free water constructed wetland (CW) was employed for removing four emerging pharmaceuticals and personal care products (PPCPs) (i.e. DEET, paracetamol, caffeine and triclosan). Orthogonal design was used to test the effect of light intensity, aeration, E.coli abundance and plant biomass on the target compounds. Synthetic wastewater contaminated with the target compounds at concentration of 25 μg/L was prepared, and both batch and continuous flow experiments were conducted. Up to 100% removals were achieved for paracetamol (PAR), caffeine (CAF) and tricolsan (TCS) while the highest removal for DEET was 32.2% in batch tests. Based on orthogonal Duncan analysis, high light intensity (240 μmolmm -2 s -1 ), full aeration, high plant biomass (1.00 kg/m 2 ) and high E.coli abundance (1.0 × 10 6  CFU/100 mL) favoured elimination of the PPCPs. Batch verification test achieved removals of 17.1%, 98.8%, 96.4% and 95.4% for DEET, PAR, CAF and TCS respectively. Continuous flow tests with CW only and CW followed by stabilization tank (CW-ST) were carried out. Final removals of the PPCP contaminants were 32.6%, 97.7%, 98.0% and 100% for DEET, PAR, CAF and TCS, respectively, by CW system alone, while 43.3%, 97.5%, 98.2% and 100%, respectively, were achieved by CW-ST system. By adding the ST tank, PPCP concentrations decreased significantly faster (p < 0.05) compared with continuous flow CW alone. In addition, after removing aerators during continuous flow CW experiments, the treatment systems presented good stability for the PPCP removals. CW-ST showed better chemical oxygen demand (COD) and total organic carbon (TOC) removals (89.3%, 91.2%, respectively) than CW only (79.4%, 85.2%, respectively). However, poor DEET removal (<50%) and high E.coli abundance (up to 1.7 log increase) in the final treated water indicated further treatment processes may be required. Statistical analysis showed significant correlations (p < 0.05) between PPCPs and water quality parameters (e.g. COD, nitrate, phosphate), and between the four PPCP compounds for the continuous flow CW and CW-ST systems. Positive results encourage further test of Greater duckweed at pilot scale CW using real wastewater. Copyright © 2017 Elsevier Ltd. All rights reserved.

Spin dynamics in storage rings and linear accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irwin, J.

1994-12-01

The purpose of these lectures is to survey the subject of spin dynamics in accelerators: to give a sense of the underlying physics, the typical analytic and numeric methods used, and an overview of results achieved. Consideration will be limited to electrons and protons. Examples of experimental and theoretical results in both linear and circular machines are included.

Finite element analyses of a linear-accelerator electron gun

NASA Astrophysics Data System (ADS)

Iqbal, M.; Wasy, A.; Islam, G. U.; Zhou, Z.

2014-02-01

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

Finite element analyses of a linear-accelerator electron gun.

PubMed

Iqbal, M; Wasy, A; Islam, G U; Zhou, Z

2014-02-01

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

Advances in high power linearly polarized fiber laser and its application

NASA Astrophysics Data System (ADS)

Zhou, Pu; Huang, Long; Ma, Pengfei; Xu, Jiangming; Su, Rongtao; Wang, Xiaolin

2017-10-01

Fiber lasers are now attracting more and more research interest due to their advantages in efficiency, beam quality and flexible operation. Up to now, most of the high power fiber lasers have random distributed polarization state. Linearlypolarized (LP) fiber lasers, which could find wide application potential in coherent detection, coherent/spectral beam combining, nonlinear frequency conversion, have been a research focus in recent years. In this paper, we will present a general review on the achievements of various kinds of high power linear-polarized fiber laser and its application. The recent progress in our group, including power scaling by using power amplifier with different mechanism, high power linearly polarized fiber laser with diversified properties, and various applications of high power linear-polarized fiber laser, are summarized. We have achieved 100 Watt level random distributed feedback fiber laser, kilowatt level continuous-wave (CW) all-fiber polarization-maintained fiber amplifier, 600 watt level average power picosecond polarization-maintained fiber amplifier and 300 watt level average power femtosecond polarization-maintained fiber amplifier. In addition, high power linearly polarized fiber lasers have been successfully applied in 5 kilowatt level coherent beam combining, structured light field and ultrasonic generation.

Enhancing the Process of Anaerobic Ammonium Oxidation Coupled to Iron Reduction in Constructed Wetland Mesocosms with Supplementation of Ferric Iron Hydroxides

NASA Astrophysics Data System (ADS)

Shuai, W.; Jaffe, P. R.

2017-12-01

Effective ammonium (NH4+) removal has been a challenge in wastewater treatment processes. Aeration, which is required for the conventional NH4+ removal approach by ammonium oxidizing bacteria, is an energy intensive process during the operation of wastewater treatment plant. The efficiency of NH4+ oxidation in natural systems is also limited by oxygen transfer in water and sediments. The objective of this study is to enhance NH4+ removal by applying a novel microbial process, anaerobic NH4+ oxidation coupled to iron (Fe) reduction (also known as Feammox), in constructed wetlands (CW). Our studies have shown that an Acidimicrobiaceae bacterium named A6 can carry out the Feammox process using ferric Fe (Fe(III)) minerals like ferrihydrite as their electron acceptor. To investigate the properties of the Feammox process in CW as well as the influence of electrodes, Feammox bacterium A6 was inoculated in planted CW mesocosms with electrodes installed at multiple depths. CW mesocosms were operated using high NH4+ nutrient solution as inflow under high or low sediment Fe(III) level. During the operation, NH4+ and ferrous Fe concentration, pore water pH, voltages between electrodes, oxidation reduction potential and dissolved oxygen were measured. At the end of the experiment, CW sediment samples at different depths were taken, DNAs were extracted and quantitative polymerase chain reaction and pyrosequencing were performed to analyze the microbial communities. The results show that the high Fe level CW mesocosm has much higher NH4+ removal ability than the low Fe level CW mesocosm after Fe-reducing conditions are developed. This indicates the enhanced NH4+ removal can be attributed to elevated Feammox activity in high Fe level CW mesocosm. The microbial community structures are different in high or low Fe level CW mesocosms and on or away from the installed electrodes. The voltages between cathode and anode increased after the injection of A6 enrichment culture in low Fe level CW mesocosm but remained stable in high Fe level CW mesocosm, indicating A6 may use electrodes as their electron acceptor in the scarcity of Fe(III). The application of Feammox process in Fe-rich CW is promising in providing a cost and energy effective NH4+ removal approach, and the electrogenesis of A6 may also be useful in enhancing the Feammox process.

In vivo near-infrared fluorescence imaging of CD105 expression during tumor angiogenesis.

PubMed

Yang, Yunan; Zhang, Yin; Hong, Hao; Liu, Glenn; Leigh, Bryan R; Cai, Weibo

2011-11-01

Angiogenesis is an indispensable process during tumor development. The currently accepted standard method for quantifying tumor angiogenesis is to assess microvessel density (MVD) based on CD105 staining, which is an independent prognostic factor for survival in patients with most solid tumor types. The goal of this study is to evaluate tumor angiogenesis in a mouse model by near-infrared fluorescence (NIRF) imaging of CD105 expression. TRC105, a human/murine chimeric anti-CD105 monoclonal antibody, was conjugated to an NIRF dye (IRDye 800CW; Ex: 778 nm; Em: 806 nm). FACS analysis and microscopy studies were performed to compare the CD105 binding affinity of TRC105 and 800CW-TRC105. In vivo/ex vivo NIRF imaging, blocking studies, and ex vivo histology were performed on 4T1 murine breast tumor-bearing mice to evaluate the ability of 800CW-TRC105 to target tumor angiogenesis. Another chimeric antibody, cetuximab, was used as an isotype-matched control. FACS analysis of human umbilical vein endothelial cells (HUVECs) revealed no difference in CD105 binding affinity between TRC105 and 800CW-TRC105, which was further validated by fluorescence microscopy. 800CW conjugation of TRC105 was achieved in excellent yield (> 85%), with an average of 0.4 800CW molecules per TRC105. Serial NIRF imaging after intravenous injection of 800CW-TRC105 revealed that the 4T1 tumor could be clearly visualized as early as 30 min post-injection. Quantitative region of interest (ROI) analysis showed that the tumor uptake peaked at about 16 h post-injection. Based on ex vivo NIRF imaging at 48 h post-injection, tumor uptake of 800CW-TRC105 was higher than most organs, thus providing excellent tumor contrast. Blocking experiments, control studies with 800CW-cetuximab and 800CW, as well as ex vivo histology all confirmed the in vivo target specificity of 800CW-TRC105. This is the first successful NIRF imaging study of CD105 expression in vivo. Fast, prominent, persistent, and CD105-specific uptake of the probe during tumor angiogenesis was observed in a mouse model. 800CW-TRC105 may be used in the clinic for imaging tumor angiogenesis within the lesions close to the skin surface, tissues accessible by endoscopy, or during image-guided surgery.

Calibration of a Six-Degree-of-Freedom Acceleration Measurement Device

DOT National Transportation Integrated Search

1994-12-01

This report describes the calibration of a six-degree-of-freedom acceleration measurement system designed for use in the measurement of linear and angular head accelerations of anthropomorphic dummies during crash tests. The calibration methodology, ...

Loss of plasmid-mediated resistance after conversion of a group B streptococcus strain to a stable cell wall deficient variant.

PubMed

Schmitt-Slomska, J; Caravano, R; El-Solh, N

1979-01-01

A group B streptococcus strain carrying plasmid DNA determining resistance to several drugs was converted by penicillin to cell wall (CW) defective and then to CW deficient variants (L-forms). The stable CW deficient variants became susceptible to antibiotics in study. Dye-buoyant density analysis of the DNA of CW deficient variants showed that the loss of antibiotic resistance was associated with the loss of extrachromosomal DNA.

Effects of metal ions and pH on ofloxacin sorption to cassava residue-derived biochar.

PubMed

Huang, Peng; Ge, Chengjun; Feng, Dan; Yu, Huamei; Luo, Jiwei; Li, Jiatong; Strong, P J; Sarmah, Ajit K; Bolan, Nanthi S; Wang, Hailong

2018-03-01

In this study, the impacts of various cations, cation strength and pH on ofloxacin (OFL) adsorption to cassava residue-derived biochars were determined. The associated adsorption mechanisms are discussed. The biochars were prepared at pyrolysis temperatures ranging from 350°C to 750°C, and labeled as CW350, CW450, CW550, CW650 and CW750. The Freundlich model provided the best fit to describe the adsorption capacity of OFL and the Freundlich coefficient (logK f ) increased with increasing pyrolysis temperature. The inclusion of Zn 2+ or Al 3+ increased OFL sorption capacities of five biochars, while Cu 2+ reduced sorption to CW450 and CW550. No significant impacts on OFL sorption were observed in the presence of K + and Ca 2+ . The concentration of Ca 2+ affected the adsorption capacity of CW550, but had no significant impact on other biochars. The pH of OFL solution, ranging from 3 to 9, had no significant changes on OFL adsorption by all the tested biochars. Results of FTIR spectra and zeta potential indicated that electrostatic interactions, cationic exchange, metal bridging and micropore filling could be the main sorption mechanism between OFL and biochars. These studies indicated that cassava residue can be converted into biochars that are effective adsorbents for removing OFL from aqueous solution. Copyright © 2017 Elsevier B.V. All rights reserved.

Effects of gamma irradiation on cell-wall constituents of some agricultural residues

NASA Astrophysics Data System (ADS)

Al-Masri, M. R.; Zarkawi, M.

1994-12-01

The effects of 150 kilogray (kGy) of γ irradiation on cell-wall constituents of cottonwood (CW), lentils straw (LS), apple pruning products (AP) and olive cake (OC) were investigated. Samples were irradiated by γ irradiation at a dose level of 150 kGy under identical conditions of temperature and humidity and analyzed for crude fibre (CF), neutral-detergent fibre (NDF), acid detergent fibre (ADF) and acid-detergent lignin (ADL). The results indicate that γ irradiation decreased CF contents by about 29% for CW, LS and AP and by 17% for OC. NDF values were also decreased by about 4% for CW and OC, and by about 12% for LS and AP. γ Irradiation treatment also decreased ADF values only for CW by 8%. ADL contents decreased by 8% for CW and 5% for OC with no effects for LS and AP. The percentage of cellulose (CL): CF ratio increased by 30, 34, 38 and 20% for CW, LS, AP and OC, respectively. Also, the percentage of hemicellulose (HCL): CF increased by 57% for CW and 16% for OC and decreased by 7% for LS and AP. The percentage of HCL: ADL increased by 22% for CW but decreased by 33% for LS and AP with no changes for OC. There were no changes in CL: ADL ratio for all residues.

Identification and phylogenetic analysis of new sulfate-reducing bacteria isolated from oilfield samples.

PubMed

Chen, Wu; Xiang, Fu; Fu, Jie; Wang, Qiang; Wang, Wenjun; Zeng, Qingfu; Yu, Longjiang

2009-01-01

Microbiologically influenced corrosion (MIC) caused by sulfate-reducing bacteria (SRB) has been investigated in an oilfield injection water system. Strain CW-01 was isolated from an oilfield and strain CW-04 was isolated from biofilm dirt of pipeline walls. The strains were facultative anaerobes, non-motile, Gram-positive, pole flagellum, and spore-forming curved rods. The growth was observed over the temperature range 20-70 degrees C. Strain CW-01 grew optimally at 37 degrees C. The pH range for growth was 3.0-11, optimal at pH 6.0. Strain CW-04 grew optimally at 48 degrees C. The pH range for growth was 3.0-10, optimal at pH 7.2. The strains grew at a very broad range of salt concentrations. Optimal growth was observed with 1.5 g/L NaCl for strain CW-01 and 0.7 g/L NaCl for strain CW-04. The strains showed most similarity in physiological characteristics, except for acetone and saccharose. Analysis of the 16S rDNA sequences allowed strains CW-01 and CW-04 to be classified into the genus Desulfotomaculum. The corrosion speciality of the strains had been comparatively investigated. Especially SRB's growth curve, bearable oxygen capability, drug fastness and corrosion rate had been analyzed. The results showed that it is difficult to prevent bacterial corrosion caused by these two strains.

Redefining fluids relative permeability for reservoir sands. (Osland oil and gas field, offshore Niger Delta, Nigeria)

NASA Astrophysics Data System (ADS)

Richardson, M. A.-A.; Taioli, F.

2018-06-01

Redefining oil and water relative permeability for the evaluation of reservoir sands, a case study of Osland oil and gas field, Offshore Niger Delta, Nigeria has been carried out. The aim of this study is to modify water relative permeability (Kwr) and oil relative permeability (Kor) equations in sandstone units. The objectives are to provide alternative expressions for Kwr and Kor in sandstone units, use the equations as inputs in a simplified water cut (Cw) equation to predict the volume of water that will be associated with the recoverable volume of oil (VRo) in penetrated reservoirs. The relationship between porosity (Φ) and water saturation (Sw) , with the relationship between porosity and hydrocarbon saturation ( Sh), were used to evaluate KWr and Kor in order to predict Cw in the selected reservoirs. Reservoir X in Well D1 shows about 2.0 ×106bbl for VRo and 18.78% for Cw but in D2 it shows about 7.4 ×106bbl and 1.73% for VRo and Cw respectively. Similarly, in Reservoir Y, D1 has about 6.8 ×106bbl of VRo and 0.034% of Cw , but in D2 it has about 9.3 ×106 bbl of VRo and 0.015% of Cw . The results suggest that high Φ with corresponding high Sw resulted in high associated Cw in Reservoir X. The evaluation also confirmed that the decrease in the ratio of oil relative permeability to water relative permeability (Kor /Kwr) corresponds to the increase in Cw . The total recoverable volumes of hydrocarbons from the two wells are estimated at 7.7 ×109cu .ft for gas and at 2.54 ×107bbl for oil. With the present conditions of the two reservoirs, the values of Cw in Reservoir X are low and are extremely low and negligible in Reservoir Y. Reservoir X in Well D1 has a smaller volume of VRo but the Cw is higher than others. Nonetheless, the Cw in Reservoir X is still within acceptable range.

Associations between intensity of child welfare involvement and child development among young children in child welfare.

PubMed

Stahmer, Aubyn C; Hurlburt, Michael; Horwitz, Sarah McCue; Landsverk, John; Zhang, Jinjin; Leslie, Laurel K

2009-09-01

To examine developmental and behavioral status of children in child welfare (CW) over time, by intensity of CW involvement using a national probability sample. As part of the National Survey of Child and Adolescent Well-being (NSCAW), data were collected on 1,049 children 12-47 months old investigated by CW agencies for possible abuse or neglect. Analyses used descriptive statistics to characterize developmental and behavioral status across four domains (developmental/cognitive, language, adaptive functioning, and behavior) by intensity of CW involvement (in-home with CW services, in-home with no CW services or out-of-home care) over time. Multivariate analyses were used to examine the relationship between independent variables (age, gender, home environment, race/ethnicity, maltreatment history, intensity of CW involvement) and follow-up domain scores. On average, children improved in developmental/cognitive, communication/language status over time, but these improvements did not differ by intensity of CW involvement. Analyses revealed a positive relationship between the home environment and change in language and adaptive behavior standard scores over time, and few predictors of change in behavioral status. An interaction between intensity of CW involvement and initial developmental/cognitive status was present. Across domains, intensity of CW involvement does not appear to have a significant effect on change in developmental and behavioral status, although out-of-home care does have differential relationships with children's developmental/cognitive status for those with very low initial cognitive/developmental status. Facilitating development in children in CW may require supportive, enriched care environments both for children remaining at home and those in foster care. Toddler and preschool age children known to child welfare are likely to have difficulties with development whether they are removed from their homes or not. It would be helpful if child welfare workers were trained to screen for developmental, language, adaptive behavior and behavioral difficulties in children in foster care, and those remaining at home. Additional support for biological, foster, and kinship caregivers in encouraging development is important for the attainment of critical developmental skills, especially for children with developmental difficulties.

A strong-focusing 800 MeV cyclotron for high-current applications

NASA Astrophysics Data System (ADS)

Pogue, N.; Assadi, S.; Badgley, K.; Comeaux, J.; Kellams, J.; McInturff, A.; McIntyre, P.; Sattarov, A.

2013-04-01

A superconducting strong-focusing cyclotron (SFC) is being developed for high-current applications. It incorporates four innovations. Superconducting quarter-wave cavities are used to provide >20 MV/turn acceleration. The orbit separation is thereby opened so that bunch-bunch interactions between successive orbits are eliminated. Quadrapole focusing channels are incorporated within the sectors so that alternating-gradient strong-focusing transport is maintained throughout. Dipole windings on the inner and outer orbits provide enhanced control for injection and extraction of bunches. Finally each sector magnet is configured as a flux-coupled stack of independent apertures, so that any desired number of independent cyclotrons can be integrated within a common footprint. Preliminary simulations indicate that each SFC should be capable of accelerating 10 mA CW to 800 MeV with very low loss and >50% energy efficiency. A primary motivation for SFC is as a proton driver for accelerator-driven subcritical fission in a molten salt core. The cores are fueled solely with the transuranics from spent nuclear fuel from a conventional nuclear power plant. The beams from one SFC stack would destroy all of the transuranics and long-lived fission products that are produced by a GWe reactor [1]. This capability offers the opportunity to close the nuclear fuel cycle and provide a path to green nuclear energy.

[Statocyst regulation of the heart and statokinetic reflexes in the crab, Hemigrapsus sanguineus, during linear acceleration].

PubMed

Kuntsova, M Ia; Sveshnikov, V G; Timofeeva, E V

1978-01-01

In experiments on the shore crab H. sanguineus studies have been made of the effect of variable longitudinal acceleration during swinging (for 15--30 min) upon cardiac activity and gravitational reflexes. High sensitivity of gravitational receptors of the canal statocyst to the effect of acceleration was demonstrated. Removal of the statocysts increases the frequency and amplitude of cardiac contractions as revealed by ECG recording. Changes in stato-kinetic coordinations cause both the disorder of overturning reactions and the disorder of reciprocal inhibition in antagonistic muscles of the dactylopodite. Statocyst regulation of skeletal muscles and heart is presumably realised via contralateral inhibitory canal which is sensitive to linear accelerations.

Novel packaging for CW and QCW diode laser modules for operation with high power and duty cycles

NASA Astrophysics Data System (ADS)

Fassbender, Wilhelm; Lotz, Jens; Kissel, Heiko; Biesenbach, Jens

2018-02-01

Continuous wave (CW) and quasi-continuous wave (QCW) operated diode laser bars and arrays have found a wide range of industrial, medical, scientific, military and space applications with a broad variety in wavelength, pulse energy, pulse duration and beam quality. Recent applications require even higher power, duty cycles and power density. The heat loss will be dissipated by conductive cooling or liquid cooling close to the bars. We present the latest performance and reliability data of two novel high-brightness CW and QCW arrays of customized and mass-production modules, in compact and robust industry design for operation with high power and high duty cycles. All designs are based on single diode packages consisting of 10mm laser bars, soft or hard soldered between expansion matched submounts. The modular components cover a wide span of designs which differ basically in water/conduction (active/passive) cooled, single, linear (horizontal and vertical) arranged designs, as well as housed and unhoused modules. The different assembling technologies of active and passive cooled base plates affect the heat dissipation and therefore the reachable power at different QCW operating conditions, as well as the lifetime. As an example, a package consisting of 8 laser diodes, connected to a 28.8*13.5*7.0mm3 DCB (direct copper bonded) submount, passively or actively cooled is considered. This design is of particular interest for mobile applications seamless module to module building system, with an infinite number of laser bars at 1.7mm pitch. Using 940nm bars we can reach an optical output power per bar of 450W at 25°C base plate temperature with 10Hz, 1.2% duty cycle and 1.2ms pulse duration. As an additional example, micro channel coolers can be vertically stacked up to 50 diodes with a 1,15mm pitch. This design is suitable for all applications, demanding also compactness and light weight and high power density. Using near infrared bars and others, we can reach an optical output power of 250W per bar at 25°C coolant temperature at CW operation.

BPA and NP removal from municipal wastewater by tropical horizontal subsurface constructed wetlands.

PubMed

Toro-Vélez, A F; Madera-Parra, C A; Peña-Varón, M R; Lee, W Y; Bezares-Cruz, J C; Walker, W S; Cárdenas-Henao, H; Quesada-Calderón, S; García-Hernández, H; Lens, P N L

2016-01-15

It has been recognized that numerous synthetic compounds like Bisphenol A (BPA) and nonylphenols (NP) are present in effluents from wastewater treatment plants (WWTP) at levels of parts per billion (μg L(-1)) or even parts per trillion (ng L(-1)) with a high potential to cause endocrine disruption in the aquatic environment. Constructed wetlands (CW) are a cost-effective wastewater treatment alternative with promising performance to treat these afore mentioned compounds. This research was aimed to evaluate the efficacy of CW treatment of WWTP effluent for mitigating the effects endocrine disrupting compounds (EDCs). This research goal was accomplished by (1) quantifying the removal of BPA and NP in CWs; (2) isolating CW fungal strains and testing for laccase production; and (3) performing endocrine disruption (reproduction) bioassays using the fruit fly Drosophila melanogaster. Three pilot scale horizontal subsurface flow constructed wetlands (HSSF-CW) were operated for eight weeks: one planted with Phragmites australis; one planted with Heliconia psitacorum; and one unplanted. The Heliconia CW showed a removal efficiency of 73.3(± 19%) and 62.8(± 20.1%) for BPA and NP, respectively; while the Phragmites CW demonstrated a similar removal for BPA (70.2 ± 27%) and lower removal efficiency for NP 52.1(± 37.1%).The unplanted CW achieved 62.2 (± 33%) removal for BPA and 25.3(± 37%) removal for NP. Four of the eleven fungal strains isolated from the Heliconia-CW showed the capacity to produce laccase. Even though complete removal of EDCs was not achieved by the CWs, the bioassay confirmed a significant improvement (p < 0.05) in fly viability for all CWs, with Heliconia sp. being the most effective at mitigating adverse effects on first and second generational reproduction. This study showed that a CW planted with a native Heliconia sp. CW demonstrated a higher removal of endocrine disrupting compounds and better mitigation of reproductive disruption in the bioassay.

Incidence of Dentinal Cracks after Root Canal Preparation with Twisted File Adaptive Instruments Using Different Kinematics.

PubMed

Karataş, Ertuğrul; Arslan, Hakan; Alsancak, Meltem; Kırıcı, Damla Özsu; Ersoy, İbrahim

2015-07-01

The purpose of the present study was to assess the effect of root canal instrumentation using Twisted File Adaptive instruments (Axis/SybronEndo, Orange, CA) with different kinematics (adaptive motion, 90° clockwise [CW]-30° counterclockwise [CCW], 150° CW-30° CCW, 210° CW-30° CCW, and continuous rotation) on crack formation. One hundred five mandibular central incisor teeth were selected. Fifteen teeth were left unprepared (control group), and the remaining 90 teeth were assigned to the 5 root canal shaping groups as follows (n = 15): adaptive motion, 90° CW-30° CCW, 150° CW-30° CCW, 210° CW-30° CCW, continuous rotation, and hand file. All the roots were sectioned horizontally at 3, 6, and 9 mm from the apex with a low-speed saw under water cooling, and the slices were then viewed through a stereomicroscope at 25× magnification. Digital images of each slice were captured using a camera to determine the presence of dentinal cracks. No cracks were observed in the control group, and the continuous rotation group had more cracks than the reciprocation groups (90° CW-30° CCW, 150° CW-30° CCW, and 210° CW-30° CCW) (P < .05). Both the continuous rotation and adaptive motion groups had significantly more dentinal cracks than the hand file group (P < .05). Regarding the different sections (3, 6, and 9 mm), there was a significant difference between the experimental groups at the 9-mm level (P < .05). The incidence of dentinal cracks is less with TF Adaptive instruments working in 210° CW-30° CCW reciprocating motion compared with working in continuous rotation and adaptive motion. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Individual Impact Magnitude vs. Cumulative Magnitude for Estimating Concussion Odds.

PubMed

O'Connor, Kathryn L; Peeters, Thomas; Szymanski, Stefan; Broglio, Steven P

2017-08-01

Helmeted impact devices have allowed researchers to investigate the biomechanics of head impacts in vivo. While increased impact magnitude has been associated with greater concussion risk, a definitive concussive threshold has not been established. It is likely that concussion risk is not determined by a single impact itself, but a host of predisposing factors. These factors may include genetics, fatigue, and/or prior head impact exposure. The objective of the current paper is to investigate the association between cumulative head impact magnitude and concussion risk. It is hypothesized that increased cumulative magnitudes will be associated with greater concussion risk. This retrospective analysis included participants that were recruited from regional high-schools in Illinois and Michigan from 2007 to 2014 as part of an ongoing study on concussion biomechanics. Across seven seasons, 185 high school football athletes were instrumented with the Head Impact Telemetry system. Out of 185 athletes, 31 (17%) sustained a concussion, with two athletes sustaining two concussions over the study period, yielding 33 concussive events. The system recorded 78,204 impacts for all concussed players. Linear acceleration, rotational acceleration, and head impact telemetry severity profile (HITsp) magnitudes were summed within five timeframes: the day of injury, three days prior to injury, seven days prior to injury, 30 days prior to injury, and prior in-season exposure. Logistic regressions were modeled to explain concussive events based on the singular linear acceleration, rotational acceleration, and HITsp event along with the calculated summations over time. Linear acceleration, rotational acceleration, and HITsp all produced significant models estimating concussion (p < 0.05). The strongest estimators of a concussive impact were the linear acceleration (OR = 1.040, p < 0.05), rotational acceleration (OR = 1.001, p < 0.05), and HITsp (OR = 1.003, p < 0.05) for the singular impact rather than any of the cumulative magnitude calculations. Moreover, no cumulative count measure was significant for linear or rotational acceleration. Results from this investigation support the growing literature indicating cumulative magnitude is not related to concussion likelihood. Cumulative magnitude is a simplistic measure of the total exposure sustained by a player over a given period. However, this measure is limited as it assumes the brain is a static structure unable to undergo self-repair. Future research should consider how biological recovery between impacts may influence concussion risk.

Leaf carbohydrate metabolism during defense

PubMed Central

Essmann, Jutta; Bones, Philipp; Weis, Engelbert

2008-01-01

The significance of cell wall invertase (cwINV) for plant defense was investigated by comparing wild type (wt) tobacco Nicotiana tabacum L. Samsun NN (SNN) with plants with RNA interference-mediated repression of cwINV (SNN::cwINV) during the interaction with the oomycetic phytopathogen Phytophthora nicotianae. We have previously shown that the transgenic plants developed normally under standard growth conditions, but exhibited weaker defense reactions in infected source leaves and were less tolerant to the pathogen. Here, we show that repression of cwINV was not accompanied by any compensatory activities of intracellular sucrose-cleaving enzymes such as vacuolar and alkaline/neutral invertases or sucrose synthase (SUSY), neither in uninfected controls nor during infection. In wt source leaves vacuolar invertase did not respond to infection, and the activity of alkaline/neutral invertases increased only slightly. SUSY however, was distinctly stimulated, in parallel to enhanced cwINV. In SNN::cwINV SUSY-activation was largely repressed upon infection. SUSY may serve to allocate sucrose into callose deposition and other carbohydrate-consuming defense reactions. Its activity, however, seems to be directly affected by cwINV and the related reflux of carbohydrates from the apoplast into the mesophyll cells. PMID:19704530

HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey.

PubMed

Karabay-Bayazit, A; Noyan, A; Bayazit, Y; Ozel, A; Anarat, A

2001-01-01

The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of them were steroid sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types of nephrotic syndrome. The results were compared with 133 healthy subjects for HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group were found significantly increased when compared to healthy controls. MCD patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p < 0.05). In conclusion, HLA groups may help in the early diagnosis of these variants.

3 μm CW lasers for myringotomy and microsurgery.

PubMed

Linden, Kurt J; Pfeffer, Christian P; Sousa, John Gary; D'Alleva, Nicholas; Aslani, Arash; Gorski, Grzegorz; Kenna, Margaret; Poe, Dennis S

2013-03-08

This paper describes the development and implementation of 3 μm lasers for myringotomy and microsurgery. Two different lasers were investigated. The first, an Er-doped, CW zirconate glass fiber laser optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.76 μm with concomitant green incoherent emission that served as a convenient visible illumination beam. The second, a 1 W CW Er:YAG solid-state laser also optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.94 μm, coincident with the strongest infrared water absorption peak. Running CW, both lasers are expected to avoid the loud acoustical shocks associated with pulsed lasers. Myringotomies were carried out with the Er:YAG laser on anaesthetized guinea pigs and the effects of the laser were documented. Laser ablated samples of tympanic membrane, soft tissue and bone were histologically examined. Histology results indicated that the CW Er:YAG laser is a potential candidate for a new myringotomy tool and possibly for otologic microsurgery, but deliverable power levels need to be increased to the 2 W (or higher) level. This work was funded under NIH SBIR Grant No. 5R44DC004899.

3-μm CW lasers for myringotomy and microsurgery

NASA Astrophysics Data System (ADS)

Linden, Kurt J.; Pfeffer, Christian P.; Sousa, John Gary; D'Alleva, Nicholas; Aslani, Arash; Gorski, Grzegorz; Kenna, Margaret; Poe, Dennis S.

2013-03-01

This paper describes the development and implementation of 3 μm lasers for myringotomy and microsurgery. Two different lasers were investigated. The first, an Er-doped, CW zirconate glass fiber laser optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.76 μm with concomitant green incoherent emission that served as a convenient visible illumination beam. The second, a 1 W CW Er:YAG solid-state laser also optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.94 μm, coincident with the strongest infrared water absorption peak. Running CW, both lasers are expected to avoid the loud acoustical shocks associated with pulsed lasers. Myringotomies were carried out with the Er:YAG laser on anaesthetized guinea pigs and the effects of the laser were documented. Laser ablated samples of tympanic membrane, soft tissue and bone were histologically examined. Histology results indicated that the CW Er:YAG laser is a potential candidate for a new myringotomy tool and possibly for otologic microsurgery, but deliverable power levels need to be increased to the 2 W (or higher) level. This work was funded under NIH SBIR Grant No. 5R44DC004899.

3 μm CW lasers for myringotomy and microsurgery

PubMed Central

Linden, Kurt J.; Pfeffer, Christian P.; Sousa, John Gary; D’Alleva, Nicholas; Aslani, Arash; Gorski, Grzegorz; Kenna, Margaret; Poe, Dennis S.

2013-01-01

This paper describes the development and implementation of 3 μm lasers for myringotomy and microsurgery. Two different lasers were investigated. The first, an Er-doped, CW zirconate glass fiber laser optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.76 μm with concomitant green incoherent emission that served as a convenient visible illumination beam. The second, a 1 W CW Er:YAG solid-state laser also optically pumped by a 970 nm diode laser, emitted > 1 W of CW power at 2.94 μm, coincident with the strongest infrared water absorption peak. Running CW, both lasers are expected to avoid the loud acoustical shocks associated with pulsed lasers. Myringotomies were carried out with the Er:YAG laser on anaesthetized guinea pigs and the effects of the laser were documented. Laser ablated samples of tympanic membrane, soft tissue and bone were histologically examined. Histology results indicated that the CW Er:YAG laser is a potential candidate for a new myringotomy tool and possibly for otologic microsurgery, but deliverable power levels need to be increased to the 2 W (or higher) level. This work was funded under NIH SBIR Grant No. 5R44DC004899. PMID:24382990

The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.

PubMed

Perry, Jason; Zhao, Yunde

2003-11-01

A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.

The sense of balance in humans: Structural features of otoconia and their response to linear acceleration

PubMed Central

Kniep, Rüdiger; Zahn, Dirk; Wulfes, Jana

2017-01-01

We explored the functional role of individual otoconia within the otolith system of mammalians responsible for the detection of linear accelerations and head tilts in relation to the gravity vector. Details of the inner structure and the shape of intact human and artificial otoconia were studied using environmental scanning electron microscopy (ESEM), including decalcification by ethylenediaminetetraacetic acid (EDTA) to discriminate local calcium carbonate density. Considerable differences between the rhombohedral faces of human and artificial otoconia already indicate that the inner architecture of otoconia is not consistent with the point group -3m. This is clearly confirmed by decalcified otoconia specimen which are characterized by a non-centrosymmetric volume distribution of the compact 3+3 branches. This structural evidence for asymmetric mass distribution was further supported by light microscopy in combination with a high speed camera showing the movement of single otoconia specimen (artificial specimen) under gravitational influence within a viscous medium (artificial endolymph). Moreover, the response of otoconia to linear acceleration forces was investigated by particle dynamics simulations. Both, time-resolved microscopy and computer simulations of otoconia acceleration show that the dislocation of otoconia include significant rotational movement stemming from density asymmetry. Based on these findings, we suggest an otolith membrane expansion/stiffening mechanism for enhanced response to linear acceleration transmitted to the vestibular hair cells. PMID:28406968

Microbial fuel cells for clogging assessment in constructed wetlands.

PubMed

Corbella, Clara; García, Joan; Puigagut, Jaume

2016-11-01

Clogging in HSSF CW may result in a reduction of system's life-span or treatment efficiency. Current available techniques to assess the degree of clogging in HSSF CW are time consuming and cannot be applied on a continuous basis. Main objective of this work was to assess the potential applicability of microbial fuel cells for continuous clogging assessment in HSSF CW. To this aim, two replicates of a membrane-less microbial fuel cell (MFC) were built up and operated under laboratory conditions for five weeks. The MFC anode was gravel-based to simulate the filter media of HSSF CW. MFC were weekly loaded with sludge that had been accumulating for several years in a pilot HSSF CW treating domestic wastewater. Sludge loading ranged from ca. 20kgTS·m(-3)CW·year(-1) at the beginning of the study period up to ca. 250kgTS·m(-3)CW·year(-1) at the end of the study period. Sludge loading applied resulted in sludge accumulated within the MFC equivalent to a clogging degree ranging from 0.2years (ca. 0.5kgTS·m(-3)CW) to ca. 5years (ca. 10kgTS·m(-3)CW). Results showed that the electric charge was negatively correlated to the amount of sludge accumulated (degree of clogging). Electron transference (expressed as electric charge) almost ceased when accumulated sludge within the MFC was equivalent to ca. 5years of clogging (ca. 10kgTS·m(-3)CW). This result suggests that, although longer study periods under more realistic conditions shall be further performed, HSSF CW operated as a MFC has great potential for clogging assessment. Copyright © 2016. Published by Elsevier B.V.

Physiological effects of night vision goggle counterweights on neck musculature of military helicopter pilots.

PubMed

Harrison, Michael F; Neary, J Patrick; Albert, Wayne J; Veillette, Major Dan W; Forcest, Canadian; McKenzie, Neil P; Croll, James C

2007-08-01

Increased helmet-mounted mass and specific neck postures have been found to be a cause of increased muscular activity and stress. However, pilots who use night vision goggles (NVG) frequently use counterweight (CW) equipment such as a lead mass that is attached to the back of the flight helmet to provide balance to counter the weight of the NVG equipment mounted to the front of the flight helmet. It is proposed that this alleviates this stress. However, no study has yet investigated the physiological effects of CW during an extended period of time during which the pilots performed normal operational tasks. Thirty-one Canadian Forces pilots were monitored on consecutive days during a day and a NVG mission in a CH-146 flight simulator. Near infrared spectroscopy probes were attached bilaterally to the trapezius muscles and hemodynamics, i.e., total oxygenation index, total hemoglobin, oxyhemoglobin, and deoxyhemoglobin, were monitored for the duration of the mission. Pilots either wore CW (n = 25) or did not wear counterweights (nCW, n = 6) as per their usual operational practice. Levene's statistical tests were conducted to test for homogeneity and only total oxygenation index returned a significant result (p < or = 0.05). For the near infrared spectroscopy variables, significant differences were found to exist between CW and nCW pilots for total hemoglobin, deoxyhemoglobin, and oxyhemoglobin during NVG flights. The CW pilots displayed less metabolic and hemodynamic stress during simulated missions as compared to the nCW pilots. The results of this study would suggest that the use of CW equipment during NVG missions in military helicopter pilots does minimize the metabolic and hemodynamic responses of the trapezius muscles.

Acceleration of boundary element method for linear elasticity

NASA Astrophysics Data System (ADS)

Zapletal, Jan; Merta, Michal; Čermák, Martin

2017-07-01

In this work we describe the accelerated assembly of system matrices for the boundary element method using the Intel Xeon Phi coprocessors. We present a model problem, provide a brief overview of its discretization and acceleration of the system matrices assembly using the coprocessors, and test the accelerated version using a numerical benchmark.

Single linearly polarized, widely and freely tunable two wavelengths Yb3+-doped fiber laser

NASA Astrophysics Data System (ADS)

Liu, Dongfeng; Wang, Chinhua

2010-01-01

We report a novel single linearly polarized, widely, freely and continuously tunable two wavelengths Yb3+-doped fiber laser. The laser generates stable arbitrary two wavelengths output between 1003.1 and 1080.7 nm peak wavelengths simultaneously with a 346.0 mW CW power by using polarization beam splitting (PBS) for separation of two wavelengths. Each lasing line shows a single polarization with a polarization extinction ratio of >20 dB under different pump levels. The central and the interval of the two wavelengths can be tuned smoothly and independently in the entire gain region of >70 nm of PM Yb3+-doped single mode fiber. Strongly enhanced polarization-hole burning (PHB) phenomena in polarization maintain (PM) Yb3+-doped fiber was observed in the tunable two wavelengths Yb3+-doped fiber laser.

Primer vector theory applied to the linear relative-motion equations. [for N-impulse space trajectory optimization

NASA Technical Reports Server (NTRS)

Jezewski, D.

1980-01-01

Prime vector theory is used in analyzing a set of linear relative-motion equations - the Clohessy-Wiltshire (C/W) equations - to determine the criteria and necessary conditions for an optimal N-impulse trajectory. The analysis develops the analytical criteria for improving a solution by: (1) moving any dependent or independent variable in the initial and/or final orbit, and (2) adding intermediate impulses. If these criteria are violated, the theory establishes a sufficient number of analytical equations. The subsequent satisfaction of these equations will result in the optimal position vectors and times of an N-impulse trajectory. The solution is examined for the specific boundary conditions of: (1) fixed-end conditions, two impulse, and time-open transfer; (2) an orbit-to-orbit transfer; and (3) a generalized renezvous problem.

Cryogenic studies for the proposed CERN large hadron electron collider (LHEC)

NASA Astrophysics Data System (ADS)

Haug, F.; LHeC Study Team, The

2012-06-01

The LHeC (Large Hadron electron Collider) is a proposed future colliding beam facility for lepton-nucleon scattering particle physics at CERN. A new 60 GeV electron accelerator will be added to the existing 27 km circumference 7 TeV LHC for collisions of electrons with protons and heavy ions. Two basic design options are being pursued. The first is a circular accelerator housed in the existing LHC tunnel which is referred to as the "Ring-Ring" version. Low field normal conducting magnets guide the particle beam while superconducting (SC) RF cavities cooled to 2 K are installed at two opposite locations at the LHC tunnel to accelerate the beams. For this version in addition a 10 GeV re-circulating SC injector will be installed. In total four refrigerators with cooling capacities between 1.2 kW and 3 kW @ 4.5 K are needed. The second option, referred to as the "Linac-Ring" version consists of a race-track re-circulating energyrecovery type machine with two 1 km long straight acceleration sections. The 944 high field 2 K SC cavities dissipate 30 kW at CW operation. Eight 10 kW @ 4.5 K refrigerators are proposed. The particle detector contains a combined SC solenoid and dipole forming the cold mass and an independent liquid argon calorimeter. Cooling is done with two individual small sized cryoplants; a 4.5 K helium, and a 87 K liquid nitrogen plant.

Chandler wobble: two more large phase jumps revealed

NASA Astrophysics Data System (ADS)

Malkin, Zinovy; Miller, Natalia

2010-12-01

Investigations of the anomalies in the Earth rotation, in particular, the polar motion components, play an important role in our understanding of the processes that drive changes in the Earth's surface, interior, atmosphere, and ocean. This paper is primarily aimed at investigation of the Chandler wobble (CW) at the whole available 163-year interval to search for the major CW amplitude and phase variations. First, the CW signal was extracted from the IERS (International Earth Rotation and Reference Systems Service) Pole coordinates time series using two digital filters: the singular spectrum analysis and Fourier transform. The CW amplitude and phase variations were examined by means of the wavelet transform and Hilbert transform. Results of our analysis have shown that, besides the well-known CW phase jump in the 1920s, two other large phase jumps have been found in the 1850s and 2000s. As in the 1920s, these phase jumps occurred contemporarily with a sharp decrease in the CW amplitude.

The Feasibility of Linear Motors and High-Energy Thrusters for Massive Aerospace Vehicles

NASA Astrophysics Data System (ADS)

Stull, M. A.

A combination of two propulsion technologies, superconducting linear motors using ambient magnetic fields and high- energy particle beam thrusters, may make it possible to develop massive aerospace vehicles the size of aircraft carriers. If certain critical thresholds can be attained, linear motors can enable massive vehicles to fly within the atmosphere and can propel them to orbit. Thrusters can do neither, because power requirements are prohibitive. However, unless superconductors having extremely high critical current densities can be developed, the interplanetary magnetic field is too weak for linear motors to provide sufficient acceleration to reach even nearby planets. On the other hand, high-energy thrusters can provide adequate acceleration using a minimal amount of reaction mass, at achievable levels of power generation. If the requirements for linear motor propulsion can be met, combining the two modes of propulsion could enable huge nuclear powered spacecraft to reach at least the inner planets of the solar system, the asteroid belt, and possibly Jupiter, in reasonably short times under continuous acceleration, opening them to exploration, resource development and colonization.

SU-F-T-554: Dark Current Effect On CyberKnife Beam Dosimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, H; Chang, A

Purpose: All RF linear accelerators produce dark current to varying degrees when an accelerating voltage and RF input is applied in the absence of electron gun injection. This study is to evaluate how dark current from the linear accelerator of CyberKnife affect the dose in the reference dosimetry. Methods: The G4 CyberKnife system with 6MV photon beam was used in this study. Using the ion chamber and the diode detector, the dose was measured in water with varying time delay between acquiring charges and staring beam-on after applying high-voltage into the linear accelerator. The dose was measured after the timemore » delay with over the range of 0 to 120 seconds in the accelerating high-voltage mode without beam-on, applying 0, 10, 50, 100, and 200 MUs. For the measurements, the collimator of 60 mm was used and the detectors were placed at the depths of 10 cm with the source-to-surface distance of 80 cm. Results: The dark current was constant over time regardless of MU. The dose due to the dark current increased over time linearly with the R-squared value of 0.9983 up to 4.4 cGy for the time 120 seconds. In the dose rate setting of 720 MU/min, the relative dose when applying the accelerating voltage without beam-on was increased over time up to 0.6% but it was less than the leakage radiation resulted from the accelerated head. As the reference dosimetry condition, when 100 MU was delivered after 10 seconds time delay, the relative dose increased by 0.7% but 6.7% for the low MU (10 MU). Conclusion: In the dosimetry using CyberKnife system, the constant dark current affected to the dose. Although the time delay in the accelerating high-voltage mode without beam-on is within 10 seconds, the dose less than 100 cGy can be overestimated more than 1%.« less

Generation and Characterization of Electron Bunches with Ramped Current Profiles in a Dual-Frequency Superconducting Linear Accelerator

DOE PAGES

Piot, P.; Behrens, C.; Gerth, C.; ...

2011-09-07

We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radiofrequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced {approx} 700-MeV bunches have peak currents of the order of a kilo-Ampere. Data taken for various accelerator settings demonstrate the versatility of the method and in particular its ability to produce current profiles that have a quasi-linear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak acceleratingmore » electric fields with transformer ratios larger than 2 in dielectric-lined waveguides.« less

Finite element analyses of a linear-accelerator electron gun

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iqbal, M., E-mail: muniqbal.chep@pu.edu.pk, E-mail: muniqbal@ihep.ac.cn; Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049; Wasy, A.

Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gunmore » is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.« less

Perception of linear acceleration in weightlessness

NASA Technical Reports Server (NTRS)

Arrott, Anthony P.; Young, Laurence R.; Merfeld, Daniel M.

1991-01-01

Tests of the perception and use of linear acceleration sensory information were performed on the science crews of the Spacelab 1 (SL-1) and D-1 missions using linear 'sleds' in-flight (D-1) and pre-post flight. The time delay between the acceleration step stimulus and the subjective response was consistently reduced during weightlessness, but was neither statistically significant nor of functional importance. Increased variability of responses when going from one environment to the other was apparent from measurements on the first day of the mission and in the first days post-flight. Subjective reports of perceived motion during sinusoidal oscillation in weightlessness were qualitatively similar to reports on earth. In a closed-loop motion nulling task, enhanced performance was observed post-flight in all crewmembers tested in the Y or Z axes.

Perception of linear acceleration in weightlessness

NASA Technical Reports Server (NTRS)

Arrott, A. P.; Young, L. R.; Merfeld, D. M.

1990-01-01

Tests of the perception and use of linear acceleration sensory information were performed on the science crews of the Spacelab 1 (SL-1) and D-1 missions using linear "sleds" in-flight (D-1) and pre-post flight. The time delay between the acceleration step stimulus and the subjective response was consistently reduced during weightlessness, but was neither statistically significant nor of functional importance. Increased variability of responses when going from one environment to the other was apparent from measurements on the first day of the mission and in the first days post-flight. Subjective reports of perceived motion during sinusoidal oscillation in weightlessness were qualitatively similar to reports on earth. In a closed-loop motion nulling task, enhanced performance was observed post-flight in all crewmembers tested in the Y or Z axes.

Accuracy of the Yamax CW-701 Pedometer for measuring steps in controlled and free-living conditions

PubMed Central

Coffman, Maren J; Reeve, Charlie L; Butler, Shannon; Keeling, Maiya; Talbot, Laura A

2016-01-01

Objective The Yamax Digi-Walker CW-701 (Yamax CW-701) is a low-cost pedometer that includes a 7-day memory, a 2-week cumulative memory, and automatically resets to zero at midnight. To date, the accuracy of the Yamax CW-701 has not been determined. The purpose of this study was to assess the accuracy of steps recorded by the Yamax CW-701 pedometer compared with actual steps and two other devices. Methods The study was conducted in a campus-based lab and in free-living settings with 22 students, faculty, and staff at a mid-sized university in the Southeastern US. While wearing a Yamax CW-701, Yamax Digi-Walker SW-200, and an ActiGraph GTX3 accelerometer, participants engaged in activities at variable speeds and conditions. To assess accuracy of each device, steps recorded were compared with actual step counts. Statistical tests included paired sample t-tests, percent accuracy, intraclass correlation coefficient, and Bland–Altman plots. Results The Yamax CW-701 demonstrated reliability and concurrent validity during walking at a fast pace and walking on a track, and in free-living conditions. Decreased accuracy was noted walking at a slow pace. Conclusions These findings are consistent with prior research. With most pedometers and accelerometers, adequate force and intensity must be present for a step to register. The Yamax CW-701 is accurate in recording steps taken while walking at a fast pace and in free-living settings. PMID:29942555

Accuracy of the Yamax CW-701 Pedometer for measuring steps in controlled and free-living conditions.

PubMed

Coffman, Maren J; Reeve, Charlie L; Butler, Shannon; Keeling, Maiya; Talbot, Laura A

2016-01-01

The Yamax Digi-Walker CW-701 (Yamax CW-701) is a low-cost pedometer that includes a 7-day memory, a 2-week cumulative memory, and automatically resets to zero at midnight. To date, the accuracy of the Yamax CW-701 has not been determined. The purpose of this study was to assess the accuracy of steps recorded by the Yamax CW-701 pedometer compared with actual steps and two other devices. The study was conducted in a campus-based lab and in free-living settings with 22 students, faculty, and staff at a mid-sized university in the Southeastern US. While wearing a Yamax CW-701, Yamax Digi-Walker SW-200, and an ActiGraph GTX3 accelerometer, participants engaged in activities at variable speeds and conditions. To assess accuracy of each device, steps recorded were compared with actual step counts. Statistical tests included paired sample t -tests, percent accuracy, intraclass correlation coefficient, and Bland-Altman plots. The Yamax CW-701 demonstrated reliability and concurrent validity during walking at a fast pace and walking on a track, and in free-living conditions. Decreased accuracy was noted walking at a slow pace. These findings are consistent with prior research. With most pedometers and accelerometers, adequate force and intensity must be present for a step to register. The Yamax CW-701 is accurate in recording steps taken while walking at a fast pace and in free-living settings.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polulyakh, Valeriy; Poutivski, Iouri

Laser Doppler Vibrometer and Range Meter (3D-MRV) is designed for middle range distances [1–100 meters]. 3D-MRV combines more than one laser in one device for a simultaneous real time measuring the distance and movement of the targets. The first laser has a short pulse (t∼30psec) and low energy (E∼200nJ) for distance measurement and the second one is a CW (continuous wave) single frequency laser for the velocity measurement with output power (P∼30mW). Both lasers perform on the eye-safe wavelength 1.5 μm. 3D-MRV uses the same mono-static optical transmitting and receiving channel for both lasers including an output telescope and amore » scanning angular system. 3D-MRV has an optical polarization switch to combine linear polarized laser beams from two lasers into one optical channel. The laser beams from both lasers by turns illuminate the target and the scattered laser radiation is collected by the telescope on a photo detector. The electrical signal from photo detector is used for measuring the distance to the target and its movement. For distance measurement the time of flight method is employed. For targets movement the optical heterodyne method is employed. The received CW laser radiation is mixed on a photo detector with the frequency-shifted laser radiation that is taken from CW laser and passed through an acousto-optic cell. The electrical signal from a photo detector on the difference frequency and phase has information about movement of the scattered targets. 3D-MVR may be used for the real time picturing of vibration of the extensive targets like bridges or aircrafts.« less

Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets.

PubMed

Poletto, R; Steibel, J P; Siegford, J M; Zanella, A J

2006-01-05

Pigs weaned at young ages show more abnormal and aggressive behaviors and cognitive deficits compared to later weaned pigs. We investigated the effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11beta-hydroxysteroid dehydrogenases 1 and 2 (11beta-HSD1 and 11beta-HSD2)] in the frontal cortex and hippocampus. Early- (EW; n = 6) and conventionally-weaned (CW; n = 6) piglets were weaned at 10 and 21 days after birth, respectively. Non-weaned (NW) piglets of both ages (NW; n = 6/group) remained with their dams. Immediately before euthanasia, half of CW, EW and NW animals were socially isolated for 15 min at 12 (EW, NW) and 23 (CW, NW) days of age. Differences in amounts of 11beta-HSD1, 11beta-HSD2, GR and MR mRNA were determined by quantitative real-time RT-PCR and data subjected to multivariate linear mixed model analysis. When compared with NW piglets at 12 days of age, the hippocampi of EW piglets showed decreased gene expression (P < 0.01). Social isolation decreased gene expression (P < 0.05) in the frontal cortex of all piglets. Twelve-day-old piglets showed higher MR mRNA in the frontal cortex (P < 0.01) and lower 11beta-HSD2 and GR mRNA (P < 0.05) in the hippocampus compared to 23-day-old animals. Results indicate that EW affected the hippocampus of piglets at 12 days of age, while social isolation affected frontal cortex regardless of age. These results may be correlated with behavioral and cognitive changes reported in EW piglets.

Cutaneous porphyrins exhibit anti-stokes fluorescence that is detectable in sebum (Conference Presentation)

NASA Astrophysics Data System (ADS)

Tian, Giselle; Zeng, Haishan; Zhao, Jianhua; Wu, Zhenguo; Al Jasser, Mohammed; Lui, Harvey; Mclean, David I.

2016-02-01

Porphyrins produced by Propionibacterium acnes represent the principal fluorophore associated with acne, and appear as orange-red luminescence under the Wood's lamp. Assessment of acne based on Wood's lamp (UV) or visible light illumination is limited by photon penetration depth and has limited sensitivity for earlier stage lesions. Inducing fluorescence with near infrared (NIR) excitation may provide an alternative way to assess porphyrin-related skin disorders. We discovered that under 785 nm CW laser excitation PpIX powder exhibits fluorescence emission in the shorter wavelength range of 600-715 nm with an intensity that is linearly dependent on the excitation power. We attribute this shorter wavelength emission to anti-Stokes fluorescence. Similar anti-Stokes fluorescence was also detected focally in all skin-derived samples containing porphyrins. Regular (Stokes) fluorescence was present under UV and visible light excitation on ex vivo nasal skin and sebum from uninflamed acne, but not on nose surface smears or sebum from inflamed acne. Co-registered CW laser-excited anti-Stokes fluorescence and fs laser-excited multi-photon fluorescence images of PpIX powder showed similar features. In the skin samples because of the anti-Stokes effect, the NIR-induced fluorescence was presumably specific for porphyrins since there appeared to be no anti-Stokes emission signals from other typical skin fluorophores such as lipids, keratins and collagen. Anti-Stokes fluorescence under NIR CW excitation is more sensitive and specific for porphyrin detection than UV- or visible light-excited regular fluorescence and fs laser-excited multi-photon fluorescence. This approach also has higher image contrast compared to NIR fs laser-based multi-photon fluorescence imaging. The anti-Stokes fluorescence of porphyrins within sebum could potentially be applied to detecting and targeting acne lesions for treatment via fluorescence image guidance.

Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein.

PubMed

Yin, Gang; Tang, Decai; Dai, Jianguo; Liu, Min; Wu, Mianhua; Sun, Y U; Yang, Zhijian; Hoffman, Robert M; Li, Lin; Zhang, Shuo; Guo, Xiuxia

2015-06-01

The present study determined the efficacy of extracts of Astragalus membranaceus (AM) and Curcuma wenyujin (CW), a traditional Chinese medicine herbal mixture, at different tumor stages of an orthotopic nude mouse model of human ovarian cancer expressing red fluorescent protein. The tumor-bearing mice were treated with cisplatinum (CDDP), AM, CW, or a combination of AM and CW in each of three tumor stages, using the same regimen. Group 1 received saline as negative control. Group 2 received CDDP i.p. as positive control with a dose of 2 mg/kg, every three days. Group 3 received AM daily via oral gavage, at a dose of 9120 mg/kg. Group 4 received CW daily via oral gavage, at a dose of 4560 mg/kg. Groups 5, 6 and 7 received combinations of AM and CW daily via oral gavage at low (AM, 2280 mg/kg; CW, 1140 mg/kg), medium (AM, 4560 mg/kg; CW 2280 mg/kg), and high (AM, 9120 mg/kg; CW, 4560 mg/kg) doses. The expression of angiogenesis- and apoptosis-related genes in the tumors were analyzed by immunohistochemistry for matrix metalloproteinase 2 (MMP-2), vascular endothelial growth factor (VEGF) fibroblast growth factor 2 (FGF-2), B-cell lymphoma 2 (Bcl-2) and cyclooxygenase 2 (Cox-2), and by polymerase chain reaction for MMP-2, FGF-2 and Bcl-2. CDDP, AM, and its combination with CW-induced significant growth inhibition of Stage I tumors. Strong efficacy of the combination of AM and CW at high dose was observed. Monotherapy with CDDP, AM, CW, and the combination treatments did not significantly inhibit Stage II and III tumors. The expression of MMP-2, VEGF, FGF-2, and Cox-2 was significantly reduced in Stage I tumors treated with AM, CW, and their combination, suggesting a possible role of these angiogenesis- and apoptosis-related genes in the observed efficacy of the agents tested. This study is the first report on the efficacy of anticancer agents at different stages of ovarian cancer in an orthotopic mouse model. As the tumor progressed, it became treatment-resistant, similar to the clinical situation, further demonstrating the utility of the model and the need for agents acrtive in advanced-stage ovarian cancer. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Linear induction accelerators made from pulse-line cavities with external pulse injection.

PubMed

Smith, I

1979-06-01

Two types of linear induction accelerator have been reported previously. In one, unidirectional voltage pulses are generated outside the accelerator and injected into the accelerator cavity modules, which contain ferromagnetic material to reduce energy losses in the form of currents induced, in parallel with the beam, in the cavity structure. In the other type, the accelerator cavity modules are themselves pulse-forming lines with energy storage and switches; parallel current losses are made zero by the use of circuits that generate bidirectional acceleration waveforms with a zero voltage-time integral. In a third type of design described here, the cavities are externally driven, and 100% efficient coupling of energy to the beam is obtained by designing the external pulse generators to produce bidirectional voltage waveforms with zero voltage-time integral. A design for such a pulse generator is described that is itself one hundred percent efficient and which is well suited to existing pulse power techniques. Two accelerator cavity designs are described that can couple the pulse from such a generator to the beam; one of these designs provides voltage doubling. Comparison is made between the accelerating gradients that can be obtained with this and the preceding types of induction accelerator.

Aligning the magnetic field of a linear induction accelerator with a low-energy electron beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, J.C.; Deadrick, F.J.; Kallman, J.S.

1989-03-10

The Experimental Test Accelerator II (ETA-II) linear induction accelerator at Lawrence Livermore National Laboratory uses a solenoid magnet in each acceleration cell to focus and transport an electron beam over the length of the accelerator. To control growth of the corkscrew mode the magnetic field must be precisely aligned over the full length of the accelerate. Concentric with each solenoid magnet is sine/cosmic-wound correction coil to steer the beam and correct field errors. A low-energy electron probe traces the central flux line through the accelerator referenced to a mechanical axis that is defined by a copropagating laser beam. Correction coilsmore » are activated to force the central flux line to cross the mechanical axis at the end of each acceleration cell. The ratios of correction coil currents determined by the low-energy electron probe are then kept fixed to correct for field errors during normal operation with an accelerated beam. We describe the construction of the low-energy electron probe and report the results of experiments we conducted to measure magnetic alignment with and without the correction coils activated. 5 refs., 3 figs.« less

An efficient magnetron transmitter for superconducting accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kazakevich, G.; Lebedev, V.; Yakovlev, V.

A concept of a highly-efficient high-power magnetron transmitter allowing wide-band phase and the mid-frequency power control at the frequency of the locking signal is proposed. The proposal is aimed for powering Superconducting RF (SRF) cavities of intensity-frontier accelerators. The transmitter is intended to operate with phase and amplitude control feedback loops allowing suppression of microphonics and beam loading in the SRF cavities. The concept utilizes injectionlocked magnetrons controlled in phase by the locking signal supplied by a feedback system. The injection-locking signal pre-excites the magnetron and allows its operation below the critical voltage. This realizes control of the magnetron powermore » in a wide range by control of the magnetron current. Pre-excitation of the magnetron by the locking signal provides an output power range up to 10 dB. Experimental studies were carried out with 2.45 GHz, 1 kW, CW magnetrons. They demonstrated stable operation of the magnetrons and power control at a low noise level. In conclusion, an analysis of the kinetics of the drifting charge in the drift approximation substantiates the concept and the experimental results.« less

Salt Stress–Induced Disassembly of Arabidopsis Cortical Microtubule Arrays Involves 26S Proteasome–Dependent Degradation of SPIRAL1[C][W

PubMed Central

Wang, Songhu; Kurepa, Jasmina; Hashimoto, Takashi; Smalle, Jan A.

2011-01-01

The dynamic instability of cortical microtubules (MTs) (i.e., their ability to rapidly alternate between phases of growth and shrinkage) plays an essential role in plant growth and development. In addition, recent studies have revealed a pivotal role for dynamic instability in the response to salt stress conditions. The salt stress response includes a rapid depolymerization of MTs followed by the formation of a new MT network that is believed to be better suited for surviving high salinity. Although this initial depolymerization response is essential for the adaptation to salt stress, the underlying molecular mechanism has remained largely unknown. Here, we show that the MT-associated protein SPIRAL1 (SPR1) plays a key role in salt stress–induced MT disassembly. SPR1, a microtubule stabilizing protein, is degraded by the 26S proteasome, and its degradation rate is accelerated in response to high salinity. We show that accelerated SPR1 degradation is required for a fast MT disassembly response to salt stress and for salt stress tolerance. PMID:21954463

Design and development of a radio frequency quadrupole linac postaccelerator for the Variable Energy Cyclotron Center rare ion beam project.

PubMed

Dechoudhury, S; Naik, V; Mondal, M; Chatterjee, A; Pandey, H K; Mandi, T K; Bandyopadhyay, A; Karmakar, P; Bhattacharjee, S; Chouhan, P S; Ali, S; Srivastava, S C L; Chakrabarti, A

2010-02-01

A four-rod type heavy-ion radio frequency quadrupole (RFQ) linac has been designed, constructed, and tested for the rare ion beam (RIB) facility project at VECC. Designed for cw operation, this RFQ is the first postaccelerator in the RIB beam line. It will accelerate A/q < or = 14 heavy ions coming from the ion source to the energy of around 100 keV/u for subsequent acceleration in a number of Interdigital H-Linac. Operating at a resonance frequency of 37.83 MHz, maximum intervane voltage of around 54 kV will be needed to achieve the final energy over a vane length of 3.12 m for a power loss of 35 kW. In the first beam tests, transmission efficiency of about 90% was measured at the QQ focus after the RFQ for O(5+) beam. In this article the design of the RFQ including the effect of vane modulation on the rf characteristics and results of beam tests will be presented.

Progress update on cryogenic system for ARIEL E-linac at TRIUMF

NASA Astrophysics Data System (ADS)

Koveshnikov, A.; Bylinskii, I.; Hodgson, G.; Yosifov, D.

2014-01-01

TRIUMF is involved in a major upgrade. The Advanced Rare IsotopeE Laboratory (ARIEL) has become a fully funded project in July 2010. A 10 mA 50 MeV SRF electron linac (e-linac) operating CW at 1.3 GHz is the key component of this initiative. This machine will serve as a second independent photo-fission driver for Rare Isotope Beams (RIB) production at TRIUMF's Isotope Separator and Accelerator (ISAC) facility. The cryogens delivery system requirements are driven by the electron accelerator cryomodule design [1, 2]. Since commencement of the project in 2010 the cryogenic system of e-linac has moved from the conceptual design phase into engineering design and procurement stage. The present document summarizes the progress in cryogenic system development and construction. Current status of e-linac cryogenic system including details of LN2 storage and delivery systems, and helium subatmospheric (SA) system is presented. The first phase of e-linac consisting of two cryomodules, cryogens storage, delivery, and distribution systems, and a 600 W class liquid helium cryoplant is scheduled for installation and commissioning by year 2014.

An efficient magnetron transmitter for superconducting accelerators

DOE PAGES

Kazakevich, G.; Lebedev, V.; Yakovlev, V.; ...

2016-09-22

A concept of a highly-efficient high-power magnetron transmitter allowing wide-band phase and the mid-frequency power control at the frequency of the locking signal is proposed. The proposal is aimed for powering Superconducting RF (SRF) cavities of intensity-frontier accelerators. The transmitter is intended to operate with phase and amplitude control feedback loops allowing suppression of microphonics and beam loading in the SRF cavities. The concept utilizes injectionlocked magnetrons controlled in phase by the locking signal supplied by a feedback system. The injection-locking signal pre-excites the magnetron and allows its operation below the critical voltage. This realizes control of the magnetron powermore » in a wide range by control of the magnetron current. Pre-excitation of the magnetron by the locking signal provides an output power range up to 10 dB. Experimental studies were carried out with 2.45 GHz, 1 kW, CW magnetrons. They demonstrated stable operation of the magnetrons and power control at a low noise level. In conclusion, an analysis of the kinetics of the drifting charge in the drift approximation substantiates the concept and the experimental results.« less

Multisite EPR oximetry from multiple quadrature harmonics.

PubMed

Ahmad, R; Som, S; Johnson, D H; Zweier, J L; Kuppusamy, P; Potter, L C

2012-01-01

Multisite continuous wave (CW) electron paramagnetic resonance (EPR) oximetry using multiple quadrature field modulation harmonics is presented. First, a recently developed digital receiver is used to extract multiple harmonics of field modulated projection data. Second, a forward model is presented that relates the projection data to unknown parameters, including linewidth at each site. Third, a maximum likelihood estimator of unknown parameters is reported using an iterative algorithm capable of jointly processing multiple quadrature harmonics. The data modeling and processing are applicable for parametric lineshapes under nonsaturating conditions. Joint processing of multiple harmonics leads to 2-3-fold acceleration of EPR data acquisition. For demonstration in two spatial dimensions, both simulations and phantom studies on an L-band system are reported. Copyright © 2011 Elsevier Inc. All rights reserved.

Noninterceptive transverse emittance measurements using BPM for Chinese ADS R&D project

NASA Astrophysics Data System (ADS)

Wang, Zhi-Jun; Feng, Chi; He, Yuan; Dou, Weiping; Tao, Yue; Chen, Wei-long; Jia, Huan; Liu, Shu-hui; Wang, Wang-sheng; Zhang, Yong; Wu, Jian-qiang; Zhang, Sheng-hu; Zhang, X. L.

2016-04-01

The noninterceptive four-dimensional transverse emittance measurements are essential for commissioning the high power continue-wave (CW) proton linacs as well as their operations. The conventional emittance measuring devices such as slits and wire scanners are not well suited under these conditions due to sure beam damages. Therefore, the method of using noninterceptive Beam Position Monitor (BPM) is developed and demonstrated on Injector Scheme II at the Chinese Accelerator Driven Sub-critical System (China-ADS) proofing facility inside Institute of Modern Physics (IMP) [1]. The results of measurements are in good agreements with wire scanners and slits at low duty-factor pulsed (LDFP) beam. In this paper, the detailed experiment designs, data analysis and result benchmarking are presented.

Thermally stimulated nonlinear refraction in gelatin stabilized Cu-PVP nanocomposite thin films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamgadge, Y. S., E-mail: ystamgadge@gmail.com; Atkare, D. V.; Pahurkar, V. G.

2016-05-06

This article illustrates investigations on thermally stimulated third order nonlinear refraction of Cu-PVP nanocomposite thin films. Cu nanoparticles have been synthesized using chemical reduction method and thin films in PVP matrix have been obtained using spin coating technique. Thin films have been characterized by X-ray diffraction (XRD) and Ultraviolet-visible (UV-vis) spectroscopyfor structural and linear optical studies. Third order nonlinear refraction studies have been performed using closed aperture z-scan technique under continuous wave (CW) He-Ne laser. Cu-PVP nanocomposites are found to exhibit strong nonlinear refractive index stimulated by thermal lensing effect.

The Effect of Rician Fading and Partial-Band Interference on Noise- Normalized Fast Frequency-Hopped MFSK Receivers

DTIC Science & Technology

1994-03-01

FSK 16. PmCI coot 17. SECURITY CLASSWsAI1OW IL SICUURW CLA$SIICATION SECURITY CLASSIICATION 20. LIMIATION Of ABSTRACT CW REPOW ? OF TiNS PAU OF ...hop k of a symbol when partial-band interference is present is obtained from (11) and the linear transformation of random variables given by (3) as...from (13) and the transformation of random variables indicated by (9) as [16] fzwjm(zwik) = f cTak!X. (Xmk, = ZmkOkI17) f~(0,kdo . -- (,.U(zk’ )fE2

Thermal lens and all optical switching of new organometallic compound doped polyacrylamide gel

NASA Astrophysics Data System (ADS)

Badran, Hussain Ali

In this work thermal lens spectrometry (TLS) is applied to investigate the thermo-optical properties of new organometallic compound containing azomethine group, Dichloro bis [2-(2-hydroxybenzylideneamino)-5-methylphenyl] telluride platinum(II), doped polyacrylamide gel using transistor-transistor logic (TTL) modulated cw 532 nm laser beam as an excitation beam modulated at 10 Hz frequency and probe beam wavelength 635 nm at 14 mW. The technique is applied to determine the thermal diffusivities, ds/dT and the linear thermal expansion coefficient of the sample. All-optical switching effects with low background and high stability are demonstrated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clendenin, James E

The International Committee supported the proposal of the Chairman of the XVIII International Linac Conference to issue a new Compendium of linear accelerators. The last one was published in 1976. The Local Organizing Committee of Linac96 decided to set up a sub-committee for this purpose. Contrary to the catalogues of the High Energy Accelerators which compile accelerators with energies above 1 GeV, we have not defined a specific limit in energy. Microtrons and cyclotrons are not in this compendium. Also data from thousands of medical and industrial linacs has not been collected. Therefore, only scientific linacs are listed in themore » present compendium. Each linac found in this research and involved in a physics context was considered. It could be used, for example, either as an injector for high energy accelerators, or in nuclear physics, materials physics, free electron lasers or synchrotron light machines. Linear accelerators are developed in three continents only: America, Asia, and Europe. This geographical distribution is kept as a basis. The compendium contains the parameters and status of scientific linacs. Most of these linacs are operational. However, many facilities under construction or design studies are also included. A special mention has been made at the end for the studies of future linear colliders.« less

Radio to Gamma-Ray Emission from Shell-Type Supernova Remnants: Predictions from Non-Linear Shock Acceleration Models

NASA Technical Reports Server (NTRS)

Baring, Matthew G.; Ellison, Donald C.; Reynolds, Stephen P.; Grenier, Isabelle A.; Goret, Philippe

1998-01-01

Supernova remnants (SNRs) are widely believed to be the principal source of galactic cosmic rays, produced by diffusive shock acceleration in the environs of the remnant's expanding blast wave. Such energetic particles can produce gamma-rays and lower energy photons via interactions with the ambient plasma. The recently reported observation of TeV gamma-rays from SN1006 by the CANGAROO Collaboration, combined with the fact that several unidentified EGRET sources have been associated with known radio/optical/X-ray-emitting remnants, provides powerful motivation for studying gamma-ray emission from SNRs. In this paper, we present results from a Monte Carlo simulation of non-linear shock structure and acceleration coupled with photon emission in shell-like SNRs. These non-linearities are a by-product of the dynamical influence of the accelerated cosmic rays on the shocked plasma and result in distributions of cosmic rays which deviate from pure power-laws. Such deviations are crucial to acceleration efficiency considerations and impact photon intensities and spectral shapes at all energies, producing GeV/TeV intensity ratios that are quite different from test particle predictions.

Optimizing charge breeding techniques for ISOL facilities in Europe: Conclusions from the EMILIE project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delahaye, P., E-mail: delahaye@ganil.fr; Jardin, P.; Maunoury, L.

The present paper summarizes the results obtained from the past few years in the framework of the Enhanced Multi-Ionization of short-Lived Isotopes for Eurisol (EMILIE) project. The EMILIE project aims at improving the charge breeding techniques with both Electron Cyclotron Resonance Ion Sources (ECRIS) and Electron Beam Ion Sources (EBISs) for European Radioactive Ion Beam (RIB) facilities. Within EMILIE, an original technique for debunching the beam from EBIS charge breeders is being developed, for making an optimal use of the capabilities of CW post-accelerators of the future facilities. Such a debunching technique should eventually resolve duty cycle and time structuremore » issues which presently complicate the data-acquisition of experiments. The results of the first tests of this technique are reported here. In comparison with charge breeding with an EBIS, the ECRIS technique had lower performance in efficiency and attainable charge state for metallic ion beams and also suffered from issues related to beam contamination. In recent years, improvements have been made which significantly reduce the differences between the two techniques, making ECRIS charge breeding more attractive especially for CW machines producing intense beams. Upgraded versions of the Phoenix charge breeder, originally developed by LPSC, will be used at SPES and GANIL/SPIRAL. These two charge breeders have benefited from studies undertaken within EMILIE, which are also briefly summarized here.« less

Wastewater polishing by a channelized macrophyte-dominated wetland and anaerobic digestion of the harvested phytomass

USDA-ARS?s Scientific Manuscript database

: Constructed wetlands (CW) offer a mechanism to meet regulatory standards for wastewater treatment while minimizing energy inputs. To optimize CW wastewater polishing activities and investigate integration of CW with energy production from anaerobic digestion we constructed a pair of three-tier ch...

Quasi-linear heating and acceleration in bi-Maxwellian plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hellinger, Petr; Passot, Thierry; Sulem, Pierre-Louis

2013-12-15

Quasi-linear acceleration and heating rates are derived for drifting bi-Maxwellian distribution functions in a general nonrelativistic case for arbitrary wave vectors, propagation angles, and growth/damping rates. The heating rates in a proton-electron plasma due to ion-cyclotron/kinetic Alfvén and mirror waves for a wide range of wavelengths, directions of propagation, and growth or damping rates are explicitly computed.

Carbon nanotube coatings as chemical absorbers

DOEpatents

Tillotson, Thomas M.; Andresen, Brian D.; Alcaraz, Armando

2004-06-15

Airborne or aqueous organic compound collection using carbon nanotubes. Exposure of carbon nanotube-coated disks to controlled atmospheres of chemical warefare (CW)-related compounds provide superior extraction and retention efficiencies compared to commercially available airborne organic compound collectors. For example, the carbon nanotube-coated collectors were four (4) times more efficient toward concentrating dimethylmethyl-phosphonate (DMMP), a CW surrogate, than Carboxen, the optimized carbonized polymer for CW-related vapor collections. In addition to DMMP, the carbon nanotube-coated material possesses high collection efficiencies for the CW-related compounds diisopropylaminoethanol (DIEA), and diisopropylmethylphosphonate (DIMP).

Modelling and experimental study of temperature profiles in cw laser diode bars

NASA Astrophysics Data System (ADS)

Bezotosnyi, V. V.; Gordeev, V. P.; Krokhin, O. N.; Mikaelyan, G. T.; Oleshchenko, V. A.; Pevtsov, V. F.; Popov, Yu M.; Cheshev, E. A.

2018-02-01

Three-dimensional simulation is used to theoretically assess temperature profiles in proposed 10-mm-wide cw laser diode bars packaged in a standard heat spreader of the C - S mount type with the aim of raising their reliable cw output power. We obtain calculated temperature differences across the emitting aperture and along the cavity. Using experimental laser bar samples with up to 60 W of cw output power, the emission spectra of individual clusters are measured at different pump currents. We compare and discuss the simulation results and experimental data.

A model for a continuous-wave iodine laser

NASA Technical Reports Server (NTRS)

Hwang, In H.; Tabibi, Bagher M.

1990-01-01

A model for a continuous-wave (CW) iodine laser has been developed and compared with the experimental results obtained from a solar-simulator-pumped CW iodine laser. The agreement between the calculated laser power output and the experimental results is generally good for various laser parameters even when the model includes only prominent rate coefficients. The flow velocity dependence of the output power shows that the CW iodine laser cannot be achieved with a flow velocity below 1 m/s for the present solar-simulator-pumped CW iodine laser system.

Characteristic of the carbon-tungsten co-deposition layers prepared by RF magnetron sputtering in a D2/Ar plasma

NASA Astrophysics Data System (ADS)

Tang, X. H.; Zhang, W. Z.; Shi, L. Q.; Qi, Q.; Zhang, B.; Zhang, W. Y.; Wang, K.; Hu, J. S.

2013-06-01

A C-W co-deposition layer, formed by radio frequency magnetron sputtering, was investigated to identify the characteristics of C-W mixed layers in fusion experimental reactors. The layers were characterized by ion beam analysis, Raman spectroscopy, X-ray diffraction and scanning electron microscopy. It was found that D atoms in C-W layers were mainly trapped by the C atoms. The ratio of C/W and D concentrations in the C-W layers deposited at a pressure of 5.0 Pa and a fixed flow rate ratio were 54/31 and 5%, respectively. They all increased significantly with increased flow rate of D2 but decreased with temperature at a relatively low level. The pressure dependence of the D concentration showed a maximum value around 5 Pa and it decreased with rising or decreasing pressure. Both Raman and X-ray analysis revealed that the structure of the C-W layers became more graphite-like with increasing temperature. Moreover, deuterium introduction made the tungsten carbide phase disappear in the deuterated C-W layers. Only erosion caves on the surface of the sample prepared at 300 K were observed by SEM. When the temperature increased, they disappeared, and convex bodies appeared.

A linear accelerator for simulated micrometeors.

NASA Technical Reports Server (NTRS)

Slattery, J. C.; Becker, D. G.; Hamermesh, B.; Roy, N. L.

1973-01-01

Review of the theory, design parameters, and construction details of a linear accelerator designed to impart meteoric velocities to charged microparticles in the 1- to 10-micron diameter range. The described linac is of the Sloan Lawrence type and, in a significant departure from conventional accelerator practice, is adapted to single particle operation by employing a square wave driving voltage with the frequency automatically adjusted from 12.5 to 125 kHz according to the variable velocity of each injected particle. Any output velocity up to about 30 km/sec can easily be selected, with a repetition rate of approximately two particles per minute.

Experimental demonstration of high efficiency electron cyclotron autoresonance acceleration

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaPointe, M.A.; Yoder, R.B.; Wang, C.

1996-04-01

First experimental results are reported on the operation of a multimegawatt 2.856 GHz cyclotron autoresonance accelerator (CARA). A 90{endash}100 kV, 2{endash}3 MW linear electron beam has had up to6.6 MW added to it in CARA, with an rf-to-beam power efficiency of up to 96{percent}. This efficiency level is larger than that reported for any fast-wave interaction between radiation and electrons, and also larger than that in normal conducting rf linear accelerators. The results obtained are in good agreement with theoretical predictions. {copyright} {ital 1996 The American Physical Society.}

Head impact exposure sustained by football players on days of diagnosed concussion.

PubMed

Beckwith, Jonathan G; Greenwald, Richard M; Chu, Jeffrey J; Crisco, Joseph J; Rowson, Steven; Duma, Stefan M; Broglio, Steven P; McAllister, Thomas W; Guskiewicz, Kevin M; Mihalik, Jason P; Anderson, Scott; Schnebel, Brock; Brolinson, P Gunnar; Collins, Michael W

2013-04-01

This study compares the frequency and severity of head impacts sustained by football players on days with and without diagnosed concussion and to identify the sensitivity and specificity of single-impact severity measures to diagnosed injury. One thousand two hundred eight players from eight collegiate football teams and six high school football teams wore instrumented helmets to measure head impacts during all team sessions, of which 95 players were diagnosed with concussion. Eight players sustained two injuries and one sustained three, providing 105 injury cases. Measures of head kinematics (peak linear and rotational acceleration, Gadd severity index, head injury criteria (HIC15), and change in head velocity (Δv)) and the number of head impacts sustained by individual players were compared between days with and without diagnosed concussion. Receiver operating characteristic curves were generated to evaluate the sensitivity and specificity of each kinematic measure to diagnosed concussion using only those impacts that directly preceded diagnosis. Players sustained a higher frequency of impacts and impacts with more severe kinematic properties on days of diagnosed concussion than on days without diagnosed concussion. Forty-five injury cases were immediately diagnosed after head impact. For these cases, peak linear acceleration and HIC15 were most sensitive to immediately diagnosed concussion (area under the curve = 0.983). Peak rotational acceleration was less sensitive to diagnosed injury than all other kinematic measures (P = 0.01), which are derived from linear acceleration (peak linear, HIC15, Gadd severity index, and Δv). Players sustained more impacts and impacts of higher severity on days of diagnosed concussion than on days without diagnosed concussion. In addition, of historical measures of impact severity, those associated with peak linear acceleration are the best predictors of immediately diagnosed concussion.

Head Impact Exposure Sustained by Football Players on Days of Diagnosed Concussion

PubMed Central

Beckwith, Jonathan G.; Greenwald, Richard M.; Chu, Jeffrey J.; Crisco, Joseph J.; Rowson, Steven; Duma, Stefan M.; Broglio, Steven P.; McAllister, Thomas W.; Guskiewicz, Kevin M.; Mihalik, Jason P.; Anderson, Scott; Schnebel, Brock; Brolinson, P. Gunnar; Collins, Michael W.

2012-01-01

Purpose This study compares the frequency and severity of head impacts sustained by football players on days with and without diagnosed concussion and to identify the sensitivity and specificity of single impact severity measures to diagnosed injury. Methods 1,208 players from eight collegiate and six high school football teams wore instrumented helmets to measure head impacts during all team sessions, of which 95 players were diagnosed with concussion. Eight players sustained two injuries and one three, providing 105 injury cases. Measures of head kinematics (peak linear and rotational acceleration, Gadd Severity Index (GSI), Head Injury Criteria (HIC15), change in head velocity (Δv)) and the number of head impacts sustained by individual players were compared between days with and without diagnosed concussion. Receiver operator characteristic curves were generated to evaluate the sensitivity and specificity of each kinematic measure to diagnosed concussion using only those impacts that directly preceded diagnosis. Results Players sustained a higher frequency of impacts and impacts with more severe kinematic properties on days of diagnosed concussion than on days without diagnosed concussion. Forty-five injury cases were immediately diagnosed following head impact. For these cases, peak linear acceleration and HIC15 were most sensitive to immediately diagnosed concussion (AUC = 0.983). Peak rotational acceleration was less sensitive to diagnosed injury than all other kinematic measures (p = 0.01) which are derived from linear acceleration (peak linear, HIC15, GSI, and Δv). Conclusions Players sustain more impacts and impacts of higher severity on days of diagnosed concussion than on days without diagnosed concussion. Additionally, of historical measures of impact severity, those associated with peak linear acceleration are the best predictors of immediately diagnosed concussion. PMID:23135363

Analysis of peripheral doses for base of tongue treatment by linear accelerator and helical TomoTherapy IMRT

PubMed Central

Lamba, Michael A. S.; Elson, Howard R.

2010-01-01

The purpose of this study was to compare the peripheral doses to various organs from a typical head and neck intensity‐modulated radiation therapy (IMRT) treatment delivered by linear accelerator (linac) and helical TomoTherapy. Multiple human CT data sets were used to segment critical structures and organs at risk, fused and adjusted to an anthropomorphic phantom. Eighteen contours were designated for thermoluminescent dosimeter (TLD) placement. Following the RTOG IMRT Protocol 0522, treatment of the primary tumor and involved nodes (PTV70) and subclinical disease sites (PTV56) was planned utilizing IMRT to 70 Gy and 56 Gy. Clinically acceptable treatment plans were produced for linac and TomoTherapy treatments. TLDs were placed and each treatment plan was delivered to the anthropomorphic phantom four times. Within 2.5 cm (one helical TomoTherapy field width) superior and inferior to the field edges, normal tissue doses were on average 45% lower using linear accelerator. Beyond 2.5 cm, the helical TomoTherapy normal tissue dose was an average of 52% lower. The majority of points proved to be statistically different using the Student's t‐test with p<0.05. Using one method of calculation, probability of a secondary malignancy was 5.88% for the linear accelerator and 4.08% for helical TomoTherapy. Helical TomoTherapy delivers more dose than a linac immediately above and below the treatment field, contributing to the higher peripheral doses adjacent to the field. At distances beyond one field width (where leakage is dominant), helical TomoTherapy doses are lower than linear accelerator doses. PACS number: 87.50.cm Dosimetry/exposure assessment

Endoluminal laser delivery mode and wavelength effects on varicose veins in an ex vivo model.

PubMed

Massaki, Ane B M N; Kiripolsky, Monika G; Detwiler, Susan P; Goldman, Mitchel P

2013-02-01

Endovenous laser ablation (EVLA) has been shown to be effective for the elimination of saphenous veins and associated reflux. Mechanism is known to be heat related, but precise way in which heat causes vein ablation is not completely known. This study aimed to determine the effects of various endovenous laser wavelengths and delivery modes on ex vivo human vein both macroscopically and microscopically. We also evaluated whether protected-tip fibers, consisting of prototype silica fibers with a metal tube over the distal end, reduced vein wall perforations compared with non-protected-tip fibers. An ex vivo EVLA model with human veins harvested during ambulatory phlebectomy procedures was used. Six laser fiber combinations were tested: 810 nm continuous wave (CW) diode laser with a flat tip fiber, 810 CW diode laser with a protected tip fiber, 1,320 nm pulsed Nd:YAG laser, 1,310 nm CW diode laser, 1,470 nm CW diode laser, and 2,100 nm pulsed Ho:YAG laser. Perforation or full thickness necrosis of a portion of the vein wall was observed in 5/11 (45%), 0/11 (0%), 3/22 (14%), 7/11 (64%), 4/6 (67%), and 5/10 (50%) of cross-sections of veins treated with the 810 nm CW diode laser with a flat tip fiber, the 810 CW diode laser with a protected tip fiber, the 1,320 nm pulsed Nd:YAG laser, the 1,310 nm CW diode laser, the 1,470 nm CW diode laser, and the 2,100 nm pulsed Ho:YAG laser, respectively. Our results have shown that the delivery mode, pulsed Nd:YAG versus CW, may be just as important as the wavelength. Therefore, the 1,310 nm CW laser may not be equivalent to the 1,320 nm pulsed laser. In addition, protected 810 nm fibers may be less likely to yield wall perforations than their non-protected counterparts. Copyright © 2012 Wiley Periodicals, Inc.

Developmental and Behavioral Needs and Service Use for Young Children in Child Welfare

PubMed Central

Stahmer, Aubyn C.; Leslie, Laurel K.; Hurlburt, Michael; Barth, Richard P.; Webb, Mary Bruce; Landsverk, John; Zhang, Jinjin

2006-01-01

Objective To determine the level of developmental and behavioral need in young children entering child welfare (CW), estimate early intervention services use, and examine variation in need and service use based on age and level of involvement with CW by using a national probability sample in the United States. Methods As part of the National Survey of Child and Adolescent Well-Being, data were collected on 2813 children <6 years old for whom possible abuse or neglect was investigated by CW agencies. Analyses used descriptive statistics to determine developmental and behavioral needs across 5 domains (cognition, behavior, communication, social, and adaptive functioning) and service use. Logistic regression was used to examine the relationship between independent variables (age, gender, race-ethnicity, maltreatment history, level of CW involvement, and developmental or behavior problems) and service use. Results Results indicate that age and level of CW involvement predict service use when controlling for need. Both toddlers (41.8%) and preschoolers (68.1%) in CW have high developmental and behavioral needs; however, few children are receiving services for these issues (22.7% overall). Children that remain with their biological parents have similar needs to those in out-of-home care but are less likely to use services. Children <3 years of age are least likely to use services. Conclusions Children referred to CW have high developmental and behavioral need regardless of the level of CW involvement. Both age and level of involvement influence service use when controlling for need. Mechanisms need to be developed to address disparities in access to intervention. PMID:16199698

Including arm exercise during a cold water immersion recovery better assists restoration of sprint cycling performance.

PubMed

Crampton, D; Egaña, M; Donne, B; Warmington, S A

2014-08-01

Sprint (high-intensity) exercise performance is reduced when immediately preceded by cold water immersion (CWI). We aimed to investigate whether this performance effect could be attenuated by combining an active recovery (arm exercise) with hip-level CWI, and whether this attenuation may be related to an effect on core temperature (Tcore ). Participants (n = 8) completed three Wingate tests before (Ex1) and after (Ex2) four different 30-min recovery interventions: CWI at 15 °C (CW15), arm exercise during CWI at 15 °C (CW15+AE), arm exercise during thermoneutral immersion at 34 °C (TW34+AE) and non-immersed arm exercise (AE). After AE and TW34+AE, performance during Ex2 was not different from Ex1; while after CW15+AE and CW15, performance was reduced by 4.9% and 7.6%, respectively. Arm exercise maintained Tcore during recovery in CW15+AE, while it declined to a larger extent upon commencement of Ex2 (-0.9 °C) when compared with CW15 (-0.6 °C). This suggests similar leg muscle cooling during recovery in CW15 and CW15+AE. Without any other significant effects (e.g., on blood lactate), these data suggest that the improvement in sprint performance following an active CWI recovery, over CWI alone, may be related to maintained Tcore and its effect on neurophysiological mechanisms that drive muscle activation, but not by reduced muscle cooling. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

An extended macro model accounting for acceleration changes with memory and numerical tests

NASA Astrophysics Data System (ADS)

Cheng, Rongjun; Ge, Hongxia; Sun, Fengxin; Wang, Jufeng

2018-09-01

Considering effect of acceleration changes with memory, an improved continuum model of traffic flow is proposed in this paper. By applying the linear stability theory, we derived the new model's linear stability condition. Through nonlinear analysis, the KdV-Burgers equation is derived to describe the propagating behavior of traffic density wave near the neutral stability line. Numerical simulation is carried out to study the extended traffic flow model, which explores how acceleration changes with memory affected each car's velocity, density and fuel consumption and exhaust emissions. Numerical results demonstrate that acceleration changes with memory have significant negative effect on dynamic characteristic of traffic flow. Furthermore, research results verify that the effect of acceleration changes with memory will deteriorate the stability of traffic flow and increase cars' total fuel consumptions and emissions during the whole evolution of small perturbation.

Separated-orbit bisected energy-recovered linear accelerator

DOEpatents

Douglas, David R.

2015-09-01

A separated-orbit bisected energy-recovered linear accelerator apparatus and method. The accelerator includes a first linac, a second linac, and a plurality of arcs of differing path lengths, including a plurality of up arcs, a plurality of downgoing arcs, and a full energy arc providing a path independent of the up arcs and downgoing arcs. The up arcs have a path length that is substantially a multiple of the RF wavelength and the full energy arc includes a path length that is substantially an odd half-integer multiple of the RF wavelength. Operation of the accelerator includes accelerating the beam utilizing the linacs and up arcs until the beam is at full energy, at full energy executing a full recirculation to the second linac using a path length that is substantially an odd half-integer of the RF wavelength, and then decelerating the beam using the linacs and downgoing arcs.

Enhanced dielectric-wall linear accelerator

DOEpatents

Sampayan, S.E.; Caporaso, G.J.; Kirbie, H.C.

1998-09-22

A dielectric-wall linear accelerator is enhanced by a high-voltage, fast e-time switch that includes a pair of electrodes between which are laminated alternating layers of isolated conductors and insulators. A high voltage is placed between the electrodes sufficient to stress the voltage breakdown of the insulator on command. A light trigger, such as a laser, is focused along at least one line along the edge surface of the laminated alternating layers of isolated conductors and insulators extending between the electrodes. The laser is energized to initiate a surface breakdown by a fluence of photons, thus causing the electrical switch to close very promptly. Such insulators and lasers are incorporated in a dielectric wall linear accelerator with Blumlein modules, and phasing is controlled by adjusting the length of fiber optic cables that carry the laser light to the insulator surface. 6 figs.

Enhanced dielectric-wall linear accelerator

DOEpatents

Sampayan, Stephen E.; Caporaso, George J.; Kirbie, Hugh C.

1998-01-01

A dielectric-wall linear accelerator is enhanced by a high-voltage, fast e-time switch that includes a pair of electrodes between which are laminated alternating layers of isolated conductors and insulators. A high voltage is placed between the electrodes sufficient to stress the voltage breakdown of the insulator on command. A light trigger, such as a laser, is focused along at least one line along the edge surface of the laminated alternating layers of isolated conductors and insulators extending between the electrodes. The laser is energized to initiate a surface breakdown by a fluence of photons, thus causing the electrical switch to close very promptly. Such insulators and lasers are incorporated in a dielectric wall linear accelerator with Blumlein modules, and phasing is controlled by adjusting the length of fiber optic cables that carry the laser light to the insulator surface.

Sex-structure, depth distribution, intermoult period and reproductive pattern of the deep-sea red crab Chaceon affinis (Brachyura, Geryonidae) in two populations in the north-eastern Atlantic

NASA Astrophysics Data System (ADS)

Biscoito, Manuel; Freitas, Mafalda; Pajuelo, José G.; Triay-Portella, Raül; Santana, José I.; Costa, Ana L.; Delgado, João; González, José A.

2015-01-01

This work investigated the biology of Chaceon affinis in two isolated populations of the Atlantic Ocean, including depth distribution, sexual structure, reproductive patterns and intermoult period. Males were larger and heavier than females. Mean size decreased with depth for both males and females. The highest abundance was found at 600-799 m of depth for males and at 800-999 m depth stratum for females. The highest abundance of ovigerous females was found at the 800-999 m depth stratum. Of the different ovaries' colour or colour shades recorded, only six categories were histologically characterized. The presence of spermatophores in the spermatheca of females in carapace stages II and III suggests that spermatophores are viable and used during the intermoult period. The size at sexual maturity in females was estimated at 104.4-104.7 mm carapace width (CW) in Madeira, and 109.3-110.5 mm CW in the Canary Islands. Only three categories of testes were identified. Mature testes consisted in a large mass, with highly coiled vasa deferentia visible to the naked eye. The size at sexual maturity in males was estimated at 113.8 mm CW in Madeira and 118.9 mm CW in the Canaries. The relative growth of males showed significant changes along the ontogeny and size at which allometric growth changes, as an indicator of morphometric maturity, occurred between 103.2 and 103.6 mm CW in Madeira and between 111.4 and 113.1 mm CW in the Canaries. In females, size at which allometric growth changes was found for maximum width of fifth abdominal somite (AS5W) at 98.2 mm CW in Madeira and 103.0 mm CW in the Canaries. The size at maturity obtained for C. affinis indicates that the minimum landing size (MLS) should not be set smaller than 125 mm CW in Madeira and 130 mm CW in the Canaries. This conservative MLS, higher than length at functional maturity, would safeguard immature individuals until they reach the size at which they can contribute to the reproductive capacity of the population. Ovigerous females were observed from October to April in Madeira, and in all months in the Canaries. Moreover, the observation of berried females in the last developmental stage in all quarters of the year suggests that gonad maturation and release of larvae are asynchronous throughout the spawning season. A total of 138 crabs with CW between 96 and 154 mm were tagged off Madeira. Of these, nine were recovered in the same area, more than 900 days after tagging. Eight of the recaptures were females with a wide range of CW confirming intermoult periods exceeding three years with expected growth per moult of less than 20 mm CW.

High-power pulsed and CW diode-pumped mode-locked Nd:YAG lasers

NASA Technical Reports Server (NTRS)

Marshall, Larry R.; Hays, A. D.; Kaz, Alex; Kasinski, Jeff; Burnham, R. L.

1991-01-01

The operation of both pulsed and CW diode-pumped mode-locked Nd:YAG lasers are presented. The pulsed laser produced 1.0 mJ with pulsewidths of 90 psec at 20 Hz. The CW pumped laser produced 6 W output at 1.064 microns and 3 W output at 532 nm.

Worldwide governmental efforts to locate and destroy chemical weapons and weapons materials: minimizing risk in transport and destruction.

PubMed

Trapp, Ralf

2006-09-01

The article gives an overview on worldwide efforts to eliminate chemical weapons and facilities for their production in the context of the implementation of the 1997 Chemical Weapons Convention (CWC). It highlights the objectives of the Organisation for the Prohibition of Chemical Weapons (OPCW), the international agency set up in The Hague to implement the CWC, and provides an overview of the present status of implementation of the CWC requirements with respect to chemical weapons (CW) destruction under strict international verification. It addresses new requirements that result from an increased threat that terrorists might attempt to acquire or manufacture CW or related materials. The article provides an overview of risks associated with CW and their elimination, from storage or recovery to destruction. It differentiates between CW in stockpile and old/abandoned CW, and gives an overview on the factors and key processes that risk assessment, management, and communication need to address. This discussion is set in the overall context of the CWC that requires the completion of the destruction of all declared CW stockpiles by 2012 at the latest.

Removal of nutrients from septic tank effluent with baffle subsurface-flow constructed wetlands.

PubMed

Cui, Lihua; Ouyang, Ying; Yang, Weizhi; Huang, Zhujian; Xu, Qiaoling; Yu, Guangwei

2015-04-15

Three new baffle flow constructed wetlands (CWs), namely the baffle horizontal flow CW (Z1), baffle vertical flow CW (Z2) and baffle hybrid flow CW (Z3), along with one traditional horizontal subsurface flow CW (Z4) were designed to test the removal efficiency of nitrogen (N) and phosphorus (P) from the septic tank effluent under varying hydraulic retention times (HRTs). Results showed that the optimal HRT was two days for maximal removal of N and P from the septic tank effluent among the four CWs. At this HRT, the Z1, Z2, Z3 and Z4 CWs removed, respectively, 49.93, 58.50, 46.01 and 44.44% of TN as well as 87.82, 93.23, 95.97 and 91.30% of TP. Our study further revealed that the Z3 CW was the best design for overall removal of N and P from the septic tank effluent due to its hybrid flow directions with better oxygen supply inside the CW system. Copyright © 2015 Elsevier Ltd. All rights reserved.

Light Source Effects on Aerosol Photoacoustic Spectroscopy Measurements

PubMed Central

Radney, James G.; Zangmeister, Christopher D.

2016-01-01

Photoacoustic spectroscopy measurements of flame-generated soot aerosol coated with small amounts of water yielded absorption enhancements that were dependent on the laser used: quasi-continuous wave (Q-CW, ≈ 650 ps pulse duration and 78 MHz repetition rate) versus continuous wave (CW). Water coating thickness was controlled by exposing the aerosol to a set relative humidity (RH). At ≈ 85 % RH, the mass of the soot particles increased by an amount comparable to a monolayer of water being deposited and enhanced the measured absorption by 36 % and 15 % for the Q-CW and CW lasers, respectively. Extinction measurements were also performed using a cavity ring-down spectrometer (extinction equals the sum of absorption and scattering) with a CW laser and negligible enhancement was observed at all RH. These findings demonstrate that source choice can impact measurements of aerosols with volatile coatings and that the absorption enhancements at high RH previously measured by Radney and Zangmeister (2015) [1] are the result of laser source used (Q-CW) and not from an increase in the particle absorption cross section. PMID:28066027

Improving associative memory in older adults with unitization.

PubMed

Ahmad, Fahad N; Fernandes, Myra; Hockley, William E

2015-01-01

We examined if unitization inherent preexperimentally could reduce the associative deficit in older adults. In Experiment 1, younger and older adults studied compound word (CW; e.g., store keeper) and noncompound word (NCW; e.g., needle birth) pairs. We found a reduction in the age-related associative deficit such that older but not younger adults showed a discrimination advantage for CW relative to NCW pairs on a yes-no associative recognition test. These results suggest that CW compared to NCW word pairs provide schematic support that older adults can use to improve their memory. In Experiment 2, reducing study time in younger adults decreased associative recognition performance, but did not produce a discrimination advantage for CW pairs. In Experiment 3, both older and younger adults showed a discrimination advantage for CW pairs on a two-alternative forced-choice recognition test, which encourages greater use of familiarity. These results suggest that test format influenced young adults' use of familiarity during associative recognition of unitized pairs, and that older adults rely more on familiarity than recollection for associative recognition. Unitization of preexperimental associations, as in CW pairs, can alleviate age-related associative deficits.

Model development, testing and experimentation in a CyberWorkstation for Brain-Machine Interface research.

PubMed

Rattanatamrong, Prapaporn; Matsunaga, Andrea; Raiturkar, Pooja; Mesa, Diego; Zhao, Ming; Mahmoudi, Babak; Digiovanna, Jack; Principe, Jose; Figueiredo, Renato; Sanchez, Justin; Fortes, Jose

2010-01-01

The CyberWorkstation (CW) is an advanced cyber-infrastructure for Brain-Machine Interface (BMI) research. It allows the development, configuration and execution of BMI computational models using high-performance computing resources. The CW's concept is implemented using a software structure in which an "experiment engine" is used to coordinate all software modules needed to capture, communicate and process brain signals and motor-control commands. A generic BMI-model template, which specifies a common interface to the CW's experiment engine, and a common communication protocol enable easy addition, removal or replacement of models without disrupting system operation. This paper reviews the essential components of the CW and shows how templates can facilitate the processes of BMI model development, testing and incorporation into the CW. It also discusses the ongoing work towards making this process infrastructure independent.

Stroop tasks reveal abnormal selective attention among psychopathic offenders.

PubMed

Hiatt, Kristina D; Schmitt, William A; Newman, Joseph P

2004-01-01

Selective attention among offenders with psychopathy was investigated using 3 Stroop paradigms: a standard color-word (CW) Stroop, a picture-word (PW) Stroop, and a color-word Stroop in which the word and color were spatially separated (separated CW). Consistent with "overselective" attention, offenders with psychopathy displayed reduced Stroop interference on the separated CW and PW tasks relative to offenders who were not psychopathic. However, offenders with psychopathy displayed normal Stroop interference on the standard CW Stroop. Further, the reduced interference of offenders with psychopathy on the separated CW Stroop was accompanied by normal facilitation. These findings suggest a circumscribed attentional deficit in psychopathy that hinders the use of unattended information that is (a) not integrated with deliberately attended information and (b) not compatible with current goal-directed behavior. ((c) 2004 APA, all rights reserved)

Response of an Impact Test Apparatus for Fall Protective Headgear Testing Using a Hybrid-III Head/Neck Assembly

PubMed Central

Caccese, V.; Ferguson, J.; Lloyd, J.; Edgecomb, M.; Seidi, M.; Hajiaghamemar, M.

2017-01-01

A test method based upon a Hybrid-III head and neck assembly that includes measurement of both linear and angular acceleration is investigated for potential use in impact testing of protective headgear. The test apparatus is based upon a twin wire drop test system modified with the head/neck assembly and associated flyarm components. This study represents a preliminary assessment of the test apparatus for use in the development of protective headgear designed to prevent injury due to falls. By including angular acceleration in the test protocol it becomes possible to assess and intentionally reduce this component of acceleration. Comparisons of standard and reduced durometer necks, various anvils, front, rear, and side drop orientations, and response data on performance of the apparatus are provided. Injury measures summarized for an unprotected drop include maximum linear and angular acceleration, head injury criteria (HIC), rotational injury criteria (RIC), and power rotational head injury criteria (PRHIC). Coefficient of variation for multiple drops ranged from 0.4 to 6.7% for linear acceleration. Angular acceleration recorded in a side drop orientation resulted in highest coefficient of variation of 16.3%. The drop test apparatus results in a reasonably repeatable test method that has potential to be used in studies of headgear designed to reduce head impact injury. PMID:28216804

A Conforming Multigrid Method for the Pure Traction Problem of Linear Elasticity: Mixed Formulation

NASA Technical Reports Server (NTRS)

Lee, Chang-Ock

1996-01-01

A multigrid method using conforming P-1 finite element is developed for the two-dimensional pure traction boundary value problem of linear elasticity. The convergence is uniform even as the material becomes nearly incompressible. A heuristic argument for acceleration of the multigrid method is discussed as well. Numerical results with and without this acceleration as well as performance estimates on a parallel computer are included.

Visual-vestibular interaction

NASA Technical Reports Server (NTRS)

Young, Laurence R.; Merfeld, D.

1994-01-01

Significant progress was achieved during the period of this grant on a number of different fronts. A list of publications, abstracts, and theses supported by this grant is provided at the end of this document. The completed studies focused on three general areas: eye movements induced by dynamic linear acceleration, eye movements and vection reports induced by visual roll stimulation, and the separation of gravito-inertial force into central estimates of gravity and linear acceleration.

Linear induction accelerator

DOEpatents

Buttram, M.T.; Ginn, J.W.

1988-06-21

A linear induction accelerator includes a plurality of adder cavities arranged in a series and provided in a structure which is evacuated so that a vacuum inductance is provided between each adder cavity and the structure. An energy storage system for the adder cavities includes a pulsed current source and a respective plurality of bipolar converting networks connected thereto. The bipolar high-voltage, high-repetition-rate square pulse train sets and resets the cavities. 4 figs.

On the measurement of wind speeds in tornadoes with a portable CW/FM-CW Doppler radar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bluestein, H.B.; Unruh, W.P.

1991-01-01

Both the formation mechanism and structure of tornadoes are not yet well understood. The Doppler radar is probably the best remote-sensing instrument at present for determining the wind field in tornadoes. Although much has been learned about the non-supercell tornado from relatively close range using Doppler radars at fixed sites, close-range measurements in supercell tornadoes are relatively few. Doppler radar can increase significantly the number of high-resolution, sub-cloud base measurements of both the tornado vortex and its parent vortex in supercells, with simultaneous visual documentation. The design details and operation of the CW/FM-CW Doppler radar developed at the Los Alamosmore » National Laboratory and used by storm-intercept teams at the Univ. of Oklahoma are described elsewhere. The radar transmits 1 W at 3 cm, and can be switched back and forth between CW and FM-CW modes. In the FM-CW mode the sweep repetition frequency is 15.575 kHz and the sweep width 1.9 MHz; the corresponding maximum unambiguous range and velocity, and range resolution are 5 km, {plus minus} 115 m s{sup {minus}1}, and 78 m respectively. The bistatic antennas, which have half-power beamwidths of 5{degree}, are easily pointed wit the aid of a boresighted VCR. FM-CW Data are recorded on the VCR, while voice documentation is recorded on the audio tape; video is recorded on another VCR. The radar and antennas are easily mounted on a tripod, and can be set up by three people in a minute or two. The purpose of this paper is to describe the signal processing techniques used to determine the Doppler spectrum in the FM-CW mode and a method of its interpretation in real time, and to present data gathered in a tornadic storm in 1990. 15 refs., 7 figs.« less

Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle

PubMed Central

2012-01-01

Background Significant quantitative trait loci (QTL) for carcass weight were previously mapped on several chromosomes in Japanese Black half-sib families. Two QTL, CW-1 and CW-2, were narrowed down to 1.1-Mb and 591-kb regions, respectively. Recent advances in genomic tools allowed us to perform a genome-wide association study (GWAS) in cattle to detect associations in a general population and estimate their effect size. Here, we performed a GWAS for carcass weight using 1156 Japanese Black steers. Results Bonferroni-corrected genome-wide significant associations were detected in three chromosomal regions on bovine chromosomes (BTA) 6, 8, and 14. The associated single nucleotide polymorphisms (SNP) on BTA 6 were in linkage disequilibrium with the SNP encoding NCAPG Ile442Met, which was previously identified as a candidate quantitative trait nucleotide for CW-2. In contrast, the most highly associated SNP on BTA 14 was located 2.3-Mb centromeric from the previously identified CW-1 region. Linkage disequilibrium mapping led to a revision of the CW-1 region within a 0.9-Mb interval around the associated SNP, and targeted resequencing followed by association analysis highlighted the quantitative trait nucleotides for bovine stature in the PLAG1-CHCHD7 intergenic region. The association on BTA 8 was accounted for by two SNP on the BovineSNP50 BeadChip and corresponded to CW-3, which was simultaneously detected by linkage analyses using half-sib families. The allele substitution effects of CW-1, CW-2, and CW-3 were 28.4, 35.3, and 35.0 kg per allele, respectively. Conclusion The GWAS revealed the genetic architecture underlying carcass weight variation in Japanese Black cattle in which three major QTL accounted for approximately one-third of the genetic variance. PMID:22607022

DNA typing revealing high HLA-Cw polymorphism completes availability of major histocompatibility complex loci in forensic medicine.

PubMed

Keresztury, L; Rajczy, K; Tauszik, T; Gyódi, E; Petrányi, G G; Falus, A

2003-03-01

Studies of human population genetics in Hungary have revealed relevant heterogeneity in the major histocompatibility complex. In the present studies, two isolated ethnic groups were chosen: people living in the Káli Basin westward from the Danube River, and those living in Opusztaszer, a village eastward from Danube, who are known as native ancient Hungarians. Blood samples were collected from 70 people in the Káli Basin and from 45 people in Opusztaszer. The frequency of HLA-Cw alleles was determined by serology as well as by DNA typing in 46 and 32 samples of the two populations, respectively, and in 44 randomly selected subjects of Hungarian origin. Compared with a random population of cadaver donors (the deaths having resulted mostly from accidents or, in a smaller number, strokes or heart infarcts) and voluntary bone marrow donors (typed in the last 10 years) recruited from all parts of Hungary and representing the mixed Hungarian population, remarkable differences were found in haplotype and allele frequencies. HLA-A, -B, -Cw typing was performed by serology and, in the case of the HLA-Cw locus, by polymerase chain reaction (PCR)-SSP and/or PCR-SSOP techniques, as well. The PCR-SSO oligotyping procedure allowed the identification of 32 Cw alleles in contrast with the 9 serologically detectable types. Because of the combination of low antigen expression and the lack of specific serologic reagents of good quality, no HLA-Cw antigens were detectable in 41%, and only one was detected in 48%, of the investigated individuals by standard serologic typing. With PCR-SSO typing, however, 97% of the investigated individuals proved to be heterozygous for HLA-Cw alleles. The two isolated populations differed from each other, from mixed Hungarian and other Caucasian populations in HLA-Cw* allele frequencies, as well as in haplotype distribution. This newly recognized polymorphism at the HLA-Cw locus completes the availability of major histocompatibility complex typing in forensic science and practice.

Laser-Induced Linear-Field Particle Acceleration in Free Space.

PubMed

Wong, Liang Jie; Hong, Kyung-Han; Carbajo, Sergio; Fallahi, Arya; Piot, Philippe; Soljačić, Marin; Joannopoulos, John D; Kärtner, Franz X; Kaminer, Ido

2017-09-11

Linear-field particle acceleration in free space (which is distinct from geometries like the linac that requires components in the vicinity of the particle) has been studied for over 20 years, and its ability to eventually produce high-quality, high energy multi-particle bunches has remained a subject of great interest. Arguments can certainly be made that linear-field particle acceleration in free space is very doubtful given that first-order electron-photon interactions are forbidden in free space. Nevertheless, we chose to develop an accurate and truly predictive theoretical formalism to explore this remote possibility when intense, few-cycle electromagnetic pulses are used in a computational experiment. The formalism includes exact treatment of Maxwell's equations and exact treatment of the interaction among the multiple individual particles at near and far field. Several surprising results emerge. We find that electrons interacting with intense laser pulses in free space are capable of gaining substantial amounts of energy that scale linearly with the field amplitude. For example, 30 keV electrons (2.5% energy spread) are accelerated to 61 MeV (0.5% spread) and to 205 MeV (0.25% spread) using 250 mJ and 2.5 J lasers respectively. These findings carry important implications for our understanding of ultrafast electron-photon interactions in strong fields.

Klystron-linac combination

DOEpatents

Stein, W.E.

1980-04-24

A combination klystron-linear accelerator which utilizes anti-bunch electrons generated in the klystron section as a source of electrons to be accelerated in the accelerator section. Electron beam current is controlled by second harmonic bunching, constrictor aperture size and magnetic focusing. Rf coupling is achieved by internal and external coupling.

Adaptation to vestibular disorientation. XI, The influence of specific and nonspecific gravi-receptors on nystagmic responses to angular acceleration.

DOT National Transportation Integrated Search

1969-10-01

Data from several recent experiments indicate that the otoliths (detectors of linear acceleration) may exert regulatory effects on responses of the semicircular canals (detectors of angular acceleration). This study was designed to explore further th...

Pulsed-focusing recirculating linacs for muon acceleration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Rolland

2014-12-31

Since the muon has a short lifetime, fast acceleration is essential for high-energy applications such as muon colliders, Higgs factories, or neutrino factories. The best one can do is to make a linear accelerator with the highest possible accelerating gradient to make the accelerating time as short as possible. However, the cost of such a single linear accelerator is prohibitively large due to expensive power sources, cavities, tunnels, and related infrastructure. As was demonstrated in the Thomas Jefferson Accelerator Facility (Jefferson Lab) Continuous Electron Beam Accelerator Facility (CEBAF), an elegant solution to reduce cost is to use magnetic return arcsmore » to recirculate the beam through the accelerating RF cavities many times, where they gain energy on each pass. In such a Recirculating Linear Accelerator (RLA), the magnetic focusing strength diminishes as the beam energy increases in a conventional linac that has constant strength quadrupoles. After some number of passes the focusing strength is insufficient to keep the beam from going unstable and being lost. In this project, the use of fast pulsed quadrupoles in the linac sections was considered for stronger focusing as a function of time to allow more successive passes of a muon beam in a recirculating linear accelerator. In one simulation, it was shown that the number of passes could be increased from 8 to 12 using pulsed magnet designs that have been developed and tested. This could reduce the cost of linac sections of a muon RLA by 8/12, where more improvement is still possible. The expense of a greater number of passes and corresponding number of return arcs was also addressed in this project by exploring the use of ramped or FFAG-style magnets in the return arcs. A better solution, invented in this project, is to use combined-function dipole-quadrupole magnets to simultaneously transport two beams of different energies through one magnet string to reduce costs of return arcs by almost a factor of two. A patent application was filed for this invention and a detailed report published in Physical Review Special Topics. A scaled model using an electron beam was developed and proposed to test the concept of a dog bone RLA with combined-function return arcs. The efforts supported by this grant were reported in a series of contributions to particle accelerator conferences that are reproduced in the appendices and summarized in the body of this report.« less

Continuous wave cavity ring-down spectroscopy for velocity distribution measurements in plasma.

PubMed

McCarren, D; Scime, E

2015-10-01

We report the development of a continuous wave cavity ring-down spectroscopic (CW-CRDS) diagnostic for real-time, in situ measurement of velocity distribution functions of ions and neutral atoms in plasma. This apparatus is less complex than conventional CW-CRDS systems. We provide a detailed description of the CW-CRDS apparatus as well as measurements of argon ions and neutrals in a high-density (10(9) cm(-3) < plasma density <10(13) cm(-3)) plasma. The CW-CRDS measurements are validated through comparison with laser induced fluorescence measurements of the same absorbing states of the ions and neutrals.

Perception of the dynamic visual vertical during sinusoidal linear motion.

PubMed

Pomante, A; Selen, L P J; Medendorp, W P

2017-10-01

The vestibular system provides information for spatial orientation. However, this information is ambiguous: because the otoliths sense the gravitoinertial force, they cannot distinguish gravitational and inertial components. As a consequence, prolonged linear acceleration of the head can be interpreted as tilt, referred to as the somatogravic effect. Previous modeling work suggests that the brain disambiguates the otolith signal according to the rules of Bayesian inference, combining noisy canal cues with the a priori assumption that prolonged linear accelerations are unlikely. Within this modeling framework the noise of the vestibular signals affects the dynamic characteristics of the tilt percept during linear whole-body motion. To test this prediction, we devised a novel paradigm to psychometrically characterize the dynamic visual vertical-as a proxy for the tilt percept-during passive sinusoidal linear motion along the interaural axis (0.33 Hz motion frequency, 1.75 m/s 2 peak acceleration, 80 cm displacement). While subjects ( n =10) kept fixation on a central body-fixed light, a line was briefly flashed (5 ms) at different phases of the motion, the orientation of which had to be judged relative to gravity. Consistent with the model's prediction, subjects showed a phase-dependent modulation of the dynamic visual vertical, with a subject-specific phase shift with respect to the imposed acceleration signal. The magnitude of this modulation was smaller than predicted, suggesting a contribution of nonvestibular signals to the dynamic visual vertical. Despite their dampening effect, our findings may point to a link between the noise components in the vestibular system and the characteristics of dynamic visual vertical. NEW & NOTEWORTHY A fundamental question in neuroscience is how the brain processes vestibular signals to infer the orientation of the body and objects in space. We show that, under sinusoidal linear motion, systematic error patterns appear in the disambiguation of linear acceleration and spatial orientation. We discuss the dynamics of these illusory percepts in terms of a dynamic Bayesian model that combines uncertainty in the vestibular signals with priors based on the natural statistics of head motion. Copyright © 2017 the American Physiological Society.

Backfilling behavior of a mixed aggregate based on construction waste and ultrafine tailings

PubMed Central

Zhang, Qinli; Xiao, Chongchun; Chen, Xin

2017-01-01

To study the possibility of utilizing mixed construction waste and ultrafine tailings (CW&UT) as a backfilling aggregate that can be placed underground in a mine, physicochemical evaluation, proportioning strength tests, and pumpability experiments were conducted. It was revealed that mixed CW&UT can be used as a backfilling aggregate due to the complementarities of their physicochemical properties. In addition, as the results of the proportioning strength tests show, the compressive strength of a cemented CW&UT backfilling specimen cured for 28 days, with a mass fraction of 72–74%, a cement-sand ratio of 1:12, and a CW proportion of 30%, is higher than 1.0 MPa, which meets the safety requirements and economic consideration of backfilling technology in many underground metal mines, and can also be enhanced with an increase in the cement-sand ratio. The results of the pumpability experiments show that cemented backfilling slurry based on CW&UT can be transported to the stope underground with a common filling pump, with a 16.6 MPa maximum pressure, with the condition that the time of emergency shut-down is less than approximately 20 min. All in all, the research to utilize mixed CW&UT as a backfilling aggregate can not only provide a way to dispose of CW&UT but also will bring large economic benefits and can provide constructive guidance for environmental protection. PMID:28662072

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant.

PubMed

Hoashi, Yohei; Tozuka, Yuichi; Takeuchi, Hirofumi

2013-02-01

Solventless dry powder coating methods have many advantages compared to solvent-based methods: they are more economical, simpler, safer, more environmentally friendly and easier to scale up. The purpose of this study was to investigate a highly effective dry powder coating method using the mechanofusion system, a mechanochemical treatment equipped with high compressive and shearing force. Acetaminophen (AAP) and carnauba wax (CW) were selected as core particles of the model drug and coating material, respectively. Mixtures of AAP and CW with and without talc were processed using the mechanofusion system. Sustained AAP release was observed by selecting appropriate processing conditions for the rotation speed and the slit size. The dissolution rate of AAP processed with CW substantially decreased with an increase in talc content up to 40% of the amount of CW loaded. Increasing the coating amount by two-step addition of CW led to more effective coating and extended drug release. Scanning electron micrographs indicated that CW adhered and showed satisfactory coverage of the surface of AAP particles. Effective CW coating onto the AAP surface was successfully achieved by strictly controlling the processing conditions and the composition of core particles, coating material and glidant. Our mechanochemical dry powder coating method using the mechanofusion system is a simple and promising means of solventless pharmaceutical coating.

Backfilling behavior of a mixed aggregate based on construction waste and ultrafine tailings.

PubMed

Chen, Qiusong; Zhang, Qinli; Xiao, Chongchun; Chen, Xin

2017-01-01

To study the possibility of utilizing mixed construction waste and ultrafine tailings (CW&UT) as a backfilling aggregate that can be placed underground in a mine, physicochemical evaluation, proportioning strength tests, and pumpability experiments were conducted. It was revealed that mixed CW&UT can be used as a backfilling aggregate due to the complementarities of their physicochemical properties. In addition, as the results of the proportioning strength tests show, the compressive strength of a cemented CW&UT backfilling specimen cured for 28 days, with a mass fraction of 72-74%, a cement-sand ratio of 1:12, and a CW proportion of 30%, is higher than 1.0 MPa, which meets the safety requirements and economic consideration of backfilling technology in many underground metal mines, and can also be enhanced with an increase in the cement-sand ratio. The results of the pumpability experiments show that cemented backfilling slurry based on CW&UT can be transported to the stope underground with a common filling pump, with a 16.6 MPa maximum pressure, with the condition that the time of emergency shut-down is less than approximately 20 min. All in all, the research to utilize mixed CW&UT as a backfilling aggregate can not only provide a way to dispose of CW&UT but also will bring large economic benefits and can provide constructive guidance for environmental protection.

Effect of boron waste on the properties of mortar and concrete.

PubMed

Topçu, Iker Bekir; Boga, Ahmet Raif

2010-07-01

Utilization of by-products or waste materials in concrete production are important subjects for sustainable development and industrial ecology concepts. The usages as mineral admixtures or fine aggregates improve the durability properties of concrete and thus increase the economic and environmental advantages for the concrete industry. The effect of clay waste (CW) containing boron on the mechanical properties of concrete was investigated. CW was added in different proportions as cement additive in concrete. The effect of CW on workability and strength of concrete were analysed by fresh and hardened concrete tests. The results obtained were compared with control concrete properties and Turkish standard values. The results showed that the addition of CW had a small effect upon the workability of the concrete but an important effect on the reduction of its strength. It was observed that strength values were quite near to that of control concrete when not more than 10% CW was used in place of cement. In addition to concrete specimens, replacing cement with CW produced mortar specimens, which were investigated for their strength and durability properties. The tests of SO( 4) (2-) and Cl(-) effect as well as freeze-thaw behaviour related to the durability of mortar were performed. Consequently, it can be said that some improvements were obtained in durability properties even if mechanical properties had decreased with increasing CW content.

Generation and characterization of electron bunches with ramped current profiles in a dual-frequency superconducting linear accelerator.

PubMed

Piot, P; Behrens, C; Gerth, C; Dohlus, M; Lemery, F; Mihalcea, D; Stoltz, P; Vogt, M

2012-01-20

We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radio frequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced ~700-MeV bunches have peak currents of the order of a kilo-Ampère. Data taken for various accelerator settings demonstrate the versatility of the method and, in particular, its ability to produce current profiles that have a quasilinear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak accelerating electric fields with transformer ratios larger than 2 in dielectric-lined waveguides. © 2012 American Physical Society

Choosing order of operations to accelerate strip structure analysis in parameter range

NASA Astrophysics Data System (ADS)

Kuksenko, S. P.; Akhunov, R. R.; Gazizov, T. R.

2018-05-01

The paper considers the issue of using iteration methods in solving the sequence of linear algebraic systems obtained in quasistatic analysis of strip structures with the method of moments. Using the analysis of 4 strip structures, the authors have proved that additional acceleration (up to 2.21 times) of the iterative process can be obtained during the process of solving linear systems repeatedly by means of choosing a proper order of operations and a preconditioner. The obtained results can be used to accelerate the process of computer-aided design of various strip structures. The choice of the order of operations to accelerate the process is quite simple, universal and could be used not only for strip structure analysis but also for a wide range of computational problems.

Modelling and Closed-Loop System Identification of a Quadrotor-Based Aerial Manipulator

NASA Astrophysics Data System (ADS)

Dube, Chioniso; Pedro, Jimoh O.

2018-05-01

This paper presents the modelling and system identification of a quadrotor-based aerial manipulator. The aerial manipulator model is first derived analytically using the Newton-Euler formulation for the quadrotor and Recursive Newton-Euler formulation for the manipulator. The aerial manipulator is then simulated with the quadrotor under Proportional Derivative (PD) control, with the manipulator in motion. The simulation data is then used for system identification of the aerial manipulator. Auto Regressive with eXogenous inputs (ARX) models are obtained from the system identification for linear accelerations \\ddot{X} and \\ddot{Y} and yaw angular acceleration \\ddot{\\psi }. For linear acceleration \\ddot{Z}, and pitch and roll angular accelerations \\ddot{θ } and \\ddot{φ }, Auto Regressive Moving Average with eXogenous inputs (ARMAX) models are identified.

Linear fixed-field multipass arcs for recirculating linear accelerators

DOE PAGES

Morozov, V. S.; Bogacz, S. A.; Roblin, Y. R.; ...

2012-06-14

Recirculating Linear Accelerators (RLA's) provide a compact and efficient way of accelerating particle beams to medium and high energies by reusing the same linac for multiple passes. In the conventional scheme, after each pass, the different energy beams coming out of the linac are separated and directed into appropriate arcs for recirculation, with each pass requiring a separate fixed-energy arc. In this paper we present a concept of an RLA return arc based on linear combined-function magnets, in which two and potentially more consecutive passes with very different energies are transported through the same string of magnets. By adjusting themore » dipole and quadrupole components of the constituting linear combined-function magnets, the arc is designed to be achromatic and to have zero initial and final reference orbit offsets for all transported beam energies. We demonstrate the concept by developing a design for a droplet-shaped return arc for a dog-bone RLA capable of transporting two beam passes with momenta different by a factor of two. Finally, we present the results of tracking simulations of the two passes and lay out the path to end-to-end design and simulation of a complete dog-bone RLA.« less

Efficient non-linear two-photon effects from the Cesium 6D manifold

NASA Astrophysics Data System (ADS)

Haluska, Nathan D.; Perram, Glen P.; Rice, Christopher A.

2018-02-01

We report several non-linear process that occur when two-photon pumping the cesium 6D states. Cesium vapor possess some of the largest two-photon pump cross sections in nature. Pumping these cross sections leads to strong amplified spontaneous emission that we observe on over 17 lasing lines. These new fields are strong enough to couple with the pump to create additional tunable lines. We use a heat pipe with cesium densities of 1014 to 1016 cm-3 and 0 to 5 Torr of helium buffer gas. The cesium 6D States are interrogated by both high energy pulses and low power CW sources. We observe four-wave mixing, six-wave mixing, potential two-photon lasing, other unknown nonlinear processes, and the persistence of some processes at low thresholds. This system is also uniquely qualified to support two-photon lasing under the proper conditions.

Linear laser diode arrays for improvement in optical disk recording

NASA Technical Reports Server (NTRS)

Alphonse, G. A.; Carlin, D. B.; Connolly, J. C.

1990-01-01

The development of individually addressable laser diode arrays for multitrack magneto-optic recorders for space stations is discussed. Three multi-element channeled substrate planar (CSP) arrays with output power greater than 30 mW with linear light vs current characteristics and stable single mode spectra were delivered to NASA. These devices have been used to demonstrate for the first time the simultaneous recording of eight data tracks on a 14-inch magneto-optic erasable disk. The yield of these devices is low, mainly due to non-uniformities inherent to the LPE growth that was used to fabricate them. The authors have recently developed the inverted CSP, based on the much more uniform MOCVD growth techniques, and have made low threshold quantum well arrays requiring about three times less current than the CSP to deliver 30 mW CW in a single spatial mode. The inverted CSP is very promising for use in space flight recorder applications.

Two-photon microscopy using fiber-based nanosecond excitation.

PubMed

Karpf, Sebastian; Eibl, Matthias; Sauer, Benjamin; Reinholz, Fred; Hüttmann, Gereon; Huber, Robert

2016-07-01

Two-photon excitation fluorescence (TPEF) microscopy is a powerful technique for sensitive tissue imaging at depths of up to 1000 micrometers. However, due to the shallow penetration, for in vivo imaging of internal organs in patients beam delivery by an endoscope is crucial. Until today, this is hindered by linear and non-linear pulse broadening of the femtosecond pulses in the optical fibers of the endoscopes. Here we present an endoscope-ready, fiber-based TPEF microscope, using nanosecond pulses at low repetition rates instead of femtosecond pulses. These nanosecond pulses lack most of the problems connected with femtosecond pulses but are equally suited for TPEF imaging. We derive and demonstrate that at given cw-power the TPEF signal only depends on the duty cycle of the laser source. Due to the higher pulse energy at the same peak power we can also demonstrate single shot two-photon fluorescence lifetime measurements.

Antigraviceptive neck muscle responses to "moving up and moving down" in human.

PubMed

Aoki, M; Han, X Y; Yamada, H; Muto, T; Satake, H; Ito, Y; Matsunami, K

2000-07-01

The responses of neck muscle to sudden transit from one 'g' to hyper 'g', work to support the head and remain the relative position of head on trunk as common observed: i.e. in sudden acceleration or deceleration by car or ejection of pilot from aircraft. Accordingly it is highly possible that the neck muscle responses to moving up may be important to prevent the neck injury due to sudden linear acceleration such as moving up against gravity. However little is known about the evaluation of mechanism of this reflex. Therefore the present study was conducted with two aims. The first aim was to investigate the neck muscle responses to vertical linear acceleration bv 0.4 g produced with an electro-hydraulic servo-system. We chose the vertical linear acceleration because it activates mainly sacculus, from which afferents have been demonstrated to be connected directly to sternocleidomastoid muscle in animals and human. The second aim was to determine whether there is a difference of neck muscle response to moving down and moving up.

Antigraviceptive neck muscle responses to "moving up and moving down" in human

NASA Technical Reports Server (NTRS)

Aoki, M.; Han, X. Y.; Yamada, H.; Muto, T.; Satake, H.; Ito, Y.; Matsunami, K.

2000-01-01

The responses of neck muscle to sudden transit from one 'g' to hyper 'g', work to support the head and remain the relative position of head on trunk as common observed: i.e. in sudden acceleration or deceleration by car or ejection of pilot from aircraft. Accordingly it is highly possible that the neck muscle responses to moving up may be important to prevent the neck injury due to sudden linear acceleration such as moving up against gravity. However little is known about the evaluation of mechanism of this reflex. Therefore the present study was conducted with two aims. The first aim was to investigate the neck muscle responses to vertical linear acceleration bv 0.4 g produced with an electro-hydraulic servo-system. We chose the vertical linear acceleration because it activates mainly sacculus, from which afferents have been demonstrated to be connected directly to sternocleidomastoid muscle in animals and human. The second aim was to determine whether there is a difference of neck muscle response to moving down and moving up.

Accelerator Generation and Thermal Separation (AGATS) of Technetium-99m

ScienceCinema

Grover, Blaine

2018-05-01

Accelerator Generation and Thermal Separation (AGATS) of Technetium-99m is a linear electron accelerator-based technology for producing medical imaging radioisotopes from a separation process that heats, vaporizes and condenses the desired radioisotope. You can learn more about INL's education programs at http://www.facebook.com/idahonationallaboratory.

Acceleration of a trailing positron bunch in a plasma wakefield accelerator

DOE PAGES

Doche, A.; Beekman, C.; Corde, S.; ...

2017-10-27

High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation colliders. Here in these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positronmore » bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. Finally, the results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.« less

Acceleration of a trailing positron bunch in a plasma wakefield accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doche, A.; Beekman, C.; Corde, S.

High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation colliders. Here in these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positronmore » bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. Finally, the results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.« less

Association of HLA haplotype with alopecia areata in Chinese Hans.

PubMed

Xiao, F-L; Ye, D-Q; Yang, S; Zhou, F-S; Zhou, S-M; Zhu, Y-G; Liang, Y-H; Ren, Y-Q; Zhang, X-J

2006-11-01

Some studies have shown discrepancies in human leucocyte antigen (HLA) associated with alopecia areata (AA) between different ethnic populations. To investigate whether HLA-I, -DQA1 and -DQB1 alleles and the HLA haplotype are associated with AA, and the correlation between the HLA haplotype profile, age of onset and severity of AA in Chinese Hans. The polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to analyse the frequencies of HLA class I, -DQA1 and -DQB1 alleles in 192 patients with AA and 252 controls in Chinese Hans. The linkage disequilibrium was calculated using the 2 x 2 table. The 24 two-locus haplotypes [including A*02-B*18, A*02-B*27, A*02-B*52, A*02-Cw*0704, A*02-DQA1*0104, A*02-DQB1*0604, A*02-DQB1*0606, B*18-Cw*0704, B*18-DQA1*0104, B*18-DQA1*0302, B*18-DQB1*0606, B*27-Cw*0704, B*27-DQA1*0104, B*27-DQA1*0302, B*52-Cw*0704, B*52-DQA1*0104, B*52-DQA1*0302, B52-DQB1*0606, Cw*0704-DQA1*0104, Cw*0704-DQA1*0302, Cw*0704-DQB1*0606, DQA1*0104-DQB1*0604, DQA1*0104-DQB1*0606, DQA1*0302-DQB1*0606 (P<0.05)] were associated with AA, while eight extended haplotypes (A*02-B*18-DQA1*0104, A*02-B*27-DQA1*0104, A*02-B*52-DQA1*0104, A*02-B*52-DQA1*0302, A*02-B*52-DQB1*0606, B*52-Cw*0704-DQA1*0104, B*52-Cw*0704-DQA1*0302, A*02-B*52-DQA1*0302-DQB1*0606) were found to be related to AA in Chinese Hans. Through stratified analysis, we found that the extended haplotype B*52-Cw*0704-DQA1*0302 was related to early onset of AA, and no haplotype was only associated with severe AA. This is the first detailed report to elucidate HLA haplotypes associated with AA and that demonstrates the significant HLA haplotypes in Chinese Hans AA. The haplotype B*52-Cw*0704-DQA1*0302 was identified to be related to early onset of AA. Our results provide some information for future research on predisposing genes in HLA regions in Chinese Hans.

Plasma block acceleration based upon the interaction between double targets and an ultra-intense linearly polarized laser pulse

NASA Astrophysics Data System (ADS)

Xu, Yanxia; Wang, Jiaxiang; Hora, Heinrich; Qi, Xin; Xing, Yifan; Yang, Lei; Zhu, Wenjun

2018-04-01

A new scheme of plasma block acceleration based upon the interaction between double targets and an ultra-intense linearly polarized laser pulse with intensity I ˜ 1022 W/cm2 is investigated via two-dimensional particle-in-cell simulations. The targets are composed of a pre-target of low-density aluminium plasma and an overdense main-target of hydrogen plasma. Through intensive parameter optimization, we have observed highly efficient plasma block accelerations with a monochromatic proton beam peaked at GeVs. The underlying mechanism is attributed to the enhancement of the charge separation field due to the properly selected pre-target.

QALMA: A computational toolkit for the analysis of quality protocols for medical linear accelerators in radiation therapy

NASA Astrophysics Data System (ADS)

Rahman, Md Mushfiqur; Lei, Yu; Kalantzis, Georgios

2018-01-01

Quality Assurance (QA) for medical linear accelerator (linac) is one of the primary concerns in external beam radiation Therapy. Continued advancements in clinical accelerators and computer control technology make the QA procedures more complex and time consuming which often, adequate software accompanied with specific phantoms is required. To ameliorate that matter, we introduce QALMA (Quality Assurance for Linac with MATLAB), a MALAB toolkit which aims to simplify the quantitative analysis of QA for linac which includes Star-Shot analysis, Picket Fence test, Winston-Lutz test, Multileaf Collimator (MLC) log file analysis and verification of light & radiation field coincidence test.

Effect of dynamic factors of space flights on the green alga Chlorella vulgaris.

PubMed

Moskvitin, E V; Vaulina, E N

1974-01-01

The biological effects of vibrational and linear acceleration on the alga Chlorella vulgaris were studied. Periodic vibration in the frequency range of 4-4000 Hz with vibrational acceleration up to 16 g did not affect the survival and mutability of Chlorella cells and did not modify the effects of acute gamma-radiation. However, random vibration similar to that occurring during launch of spaceships, combined with linear acceleration increased the radiation damage to algae produced by acute gamma-radiation at a dose of 10000 r. This effect is seen only in cells at the beginning of the G1 stage, which precedes DNA synthesis.

Preliminary design of a high-intensity continuous-wave deuteron RFQ

NASA Astrophysics Data System (ADS)

Liu, X.; Kamigaito, O.; Sakamoto, N.; Yamada, K.

2017-07-01

A high-intensity deuteron linear accelerator is currently being studied as a promising candidate to treat high-level radioactive waste through the nuclear transmutation process. This paper presents the study on a design of a 75.5 MHz, 400 mA, continuous-wave deuteron radio-frequency quadrupole (RFQ), which is proposed as the front-end of such a linear accelerator. The results of the beam dynamics simulation suggest that the designed RFQ can accelerate a 400-mA deuteron beam from 100 keV to 2.5 MeV with a transmission rate of 92.0 ∼ 93.3%, depending on the assumed input transverse emittance.

Preclinical Comparison of Near-Infrared-Labeled Cetuximab and Panitumumab for Optical Imaging of Head and Neck Squamous Cell Carcinoma

PubMed Central

Day, Kristine E.; Sweeny, Larissa; Kulbersh, Brian; Zinn, Kurt R.; Rosenthal, Eben L.

2014-01-01

Purpose: Though various targets have been proposed and evaluated, no agent has yet been investigated in a clinical setting for head and neck cancer. The present study aimed to compare two fluorescently labeled anti-epidermal growth factor receptor (EGFR) antibodies for detection of head and neck squamous cell carcinoma (HNSCC). Procedures: Antigen specificities and in vitro imaging of the fluorescently labeled anti-EGFR antibodies were performed. Next, immunodeficient mice (n=22) bearing HNSCC (OSC-19 and SCC-1) tongue tumors received systemic injections of cetuximab-IRDye800CW, panitumumab-IRDye800CW, or IgG-IRDye800CW (a nonspecific control). Tumors were imaged and resected using two near-infrared imaging systems, SPY and Pearl. Fluorescent lymph nodes were also identified, and all resected tissues were sent for pathology. Results: Panitumumab-IRDye800CW and cetuximab-IRDye800CW had specific and high affinity binding for EGFR (KD=0.12 and 0.31 nM, respectively). Panitumumab-IRDye800CW demonstrated a 2-fold increase in fluorescence intensity compared to cetuximab-IRDye800CW in vitro. In vivo, both fluorescently labeled antibodies produced higher tumor-to-background ratios compared to IgG-IRDye800CW. However, there was no significant difference between the two in either cell line or imaging modality (OSC-19: p=0.08 SPY, p=0.48 Pearl; SCC-1: p=0.77 SPY, p=0.59 Pearl; paired t tests). Conclusions: There was no significant difference between the two fluorescently labeled anti-EGFR monoclonal antibodies in murine models of HNSCC. Both cetuximab and panitumumab can be considered suitable targeting agents for fluorescent intraoperative detection of HNSCC. PMID:23715932

Major depressive episodes are associated with poor concordance with therapy in rheumatoid arthritis patients: the impact on disease outcomes.

PubMed

Cabrera-Marroquín, Ricardo; Contreras-Yáñez, Irazú; Alcocer-Castillejos, Natasha; Pascual-Ramos, Virginia

2014-01-01

Our objective was to investigate associations between major depressive episodes (MDE), concordance with therapy (CwT) and disease outcomes in rheumatoid arthritis patients. Seventy-eight outpatients receiving ≥1 disease modifying anti-rheumatic drug and without significant comorbidity had concomitant rheumatic and psychiatric evaluations. CwT was defined according to a questionnaire. MDE was defined using the Mini International Neuropsychiatric Interview and the severity of depressive symptoms was assessed with the Beck Depression Inventory (BDI-II). Appropriated statistic was used. IRB approval was obtained. Patients included (73 ♀) had (mean±SD) age of 44±10 years and (median, range) disease duration of 10 years (5.2-15.8). Current MDE were diagnosed in 24 patients (30.8%); 60 patients (76.9%) were CwT. Patient-non-CwT were more frequently diagnosed with MDE and tend to have higher BDI scores. They had significantly more disease activity according to patient-pain VAS and swollen joint counts. Both groups were similar regarding demographic variables, treatment and comorbid conditions. Forty-one patients (53%) had clinically important depressive symptoms (BDI≥10), among them 20 had mild depression, 14 moderate and 7 severe depression. Patient-non-CwT had more frequently moderate depression (according to BDI score) than their counterparts and similar tendency was found regarding severe depression. Patient-CwT who additionally had lower BDI scores had better disease outcomes than concordant patients with higher BDI scores. Similar results were found in non-CwT patients but statistical significance was limited to disease activity. Prevalence of current MDE in RA patients was of 31%; those patients had poorer CwT and worse outcomes than mentally healthy patients.

Electricity production from Azo dye wastewater using a microbial fuel cell coupled constructed wetland operating under different operating conditions.

PubMed

Fang, Zhou; Song, Hai-Liang; Cang, Ning; Li, Xian-Ning

2015-06-15

Microbial fuel cells (MFCs) have got tremendous attention for their capability to enhance the degradation of some recalcitrant pollutants and simultaneous electricity production. A microbial fuel cell coupled constructed wetland (CW-MFC) is a new device to treat the wastewater and produce energy which has more wastewater treatment volume and more easily to maintenance than others MFCs. The studies on the performance of CW-MFCs are necessary. In this work, the effects of hydraulic residence time (HRT), reactive brilliant red X-3B (ABRX3) proportion and COD concentration on the electricity production of CW-MFC and the degradation characteristics of ABRX3 were investigated. The decolorization rate and the electricity production increased to a peak before slowing down with the elongation of HRT. The highest decolorization rate and electricity production were obtained when HRT was 3 days. The ABRX3 proportion (calculated as COD) in the wastewater played an important role in decolorization and electricity production, which may influence the distribution of electrons in the system. The power density of CW-MFC and the decolorization rate decreased concomitantly with an increasing ABRX3 proportion. The COD concentration influenced the CW-MFC performance slightly. The highest decolorization rate and power density reached 95.6% and 0.852 W/m(3), respectively, when the COD concentration was 300 mg/L while the ABRX3 proportion was 30%. The coulombic efficiency of the CW-MFC depended on glucose and ABRX3 proportions in the wastewater. ABRX3 acquired more electrons than the anode. Further investigations are needed to optimize CW-MFC performance and explain the mechanism of biorefractory compounds degradation and electron motion in CW-MFCs. Copyright © 2014 Elsevier B.V. All rights reserved.

Terahertz transmission properties of silicon wafers using continuous-wave terahertz spectroscopy

NASA Astrophysics Data System (ADS)

Kim, Chihoon; Ahn, Jae Sung; Ji, Taeksoo; Eom, Joo Beom

2017-04-01

We present the spectral properties of Si wafers using continuous-wave terahertz (CW-THz) spectroscopy. By using a tunable laser source and a fixed distributed-feedback laser diode (DFB-LD), a stably tunable beat source for CW-THz spectroscopy system can be implemented. THz radiation is generated in the frequency range of 100 GHz-800 GHz by photomixing in a photoconductive antenna. We also measured CW-THz waveforms by changing the beat frequency and confirmed repeatability through repeated measurement. We calculated the peaks of the THz frequency by taking fast Fourier transforms (FFTs) of measured THz waveforms. The feasibility of CW-THz spectroscopy is demonstrated by the THz spectra of Si wafers with different resistivities, mobilities, and carrier concentrations. The results show that Si wafers with a lower resistivity absorb more THz waves. Thus, we expect our CW-THz system to have the advantage of being able to perform fast non-destructive analysis.

The ability of non-computer tasks to increase biomechanical exposure variability in computer-intensive office work.

PubMed

Barbieri, Dechristian França; Srinivasan, Divya; Mathiassen, Svend Erik; Nogueira, Helen Cristina; Oliveira, Ana Beatriz

2015-01-01

Postures and muscle activity in the upper body were recorded from 50 academics office workers during 2 hours of normal work, categorised by observation into computer work (CW) and three non-computer (NC) tasks (NC seated work, NC standing/walking work and breaks). NC tasks differed significantly in exposures from CW, with standing/walking NC tasks representing the largest contrasts for most of the exposure variables. For the majority of workers, exposure variability was larger in their present job than in CW alone, as measured by the job variance ratio (JVR), i.e. the ratio between min-min variabilities in the job and in CW. Calculations of JVRs for simulated jobs containing different proportions of CW showed that variability could, indeed, be increased by redistributing available tasks, but that substantial increases could only be achieved by introducing more vigorous tasks in the job, in casu illustrated by cleaning.

Measurement of the 1s2s ^1S0 - 1s2p ^3P1 interval in helium-like silicon.

NASA Astrophysics Data System (ADS)

Redshaw, M.; Harry, R.; Myers, E. G.; Weatherford, C. A.

2001-05-01

Accurate calculation of the energy levels of helium-like ions is a basic problem in relativistic atomic theory. For the n=3D2 levels at moderate Z, published calculations give all ``structure'' but not all explicit QED contributions to order (Zα)^4 a.u.(D.R. Plante, W.R. Johnson and J. Sapirstein, Phys. Rev. A 49), 3519 (1994).^, (K.T. Cheng, M.H. Chen, W.R. Johnson and J. Sapirstein, Phys. Rev. A 50), 247 (1994).. Measurements of the 1s2p ^3P - 1s2s ^3S transitions, which lie in the vacuum ultra-violet, are barely precise enough to challenge the theory. However, the intercombination 1s2s ^1S0 - 1s2p ^3P1 interval lies in the infra-red for Z<40 and enables precision measurements using laser spectroscopy(E.G. Myers, J.K. Thompson, E.P. Gavathas, N.R. Claussen, J.D. Silver and D.J.H. Howie, Phys. Rev. Lett. 75), 3637 (1995).. We aim to measure this interval in Si^12+ using a foil-stripped 1 MeV/u ion beam from the Florida State Van de Graaff accelerator and a single-mode c.w. Nd:YAG laser at 1.319 μm. To obtain a sufficient transition probability, the Si^12+ beam is merged co-linearly with the laser light inside an ultra-high finesse build-up cavity. The results should provide a clear test of current and developing calculations of QED contributions in two-electron ions.