International Developments in Post-Secondary, Short-Cycle Education: Report of a Wingspread Conference convened by the American Association of Community and Junior Colleges in cooperation with the Johnson Foundation at Wingspread (Racine, Wisconsin, October 25-27, 1978)

ERIC Educational Resources Information Center

Fersh, Seymour, Ed.

At the "International Developments in Post-Secondary, Short-Cycle Education Conference," attention centered on the common interests of community colleges in the United States and institutions with like roles in other countries. Among the mutual interests and topics discussed were: community involvement in planning and conducting…

From Beginning to End: How Engineering Students Think and Talk about Sustainability across the Life Cycle. Research Brief

ERIC Educational Resources Information Center

Kilgore, Deborah; Jocuns, Andrew; Yasuhara, Ken; Atman, Cynthia J.

2009-01-01

The Academic Pathways Study (APS) is a multi-institution, mixed-methods, longitudinal study which examines engineering students' learning and development as they move into, through, and beyond their undergraduate institutions (Atman et al., 2008; Sheppard et al., 2004). It is part of the Center for the Advancement of Engineering Education…

The Economic Impact of Community College Capacity Development in Developing Countries: A Longitudinal Analysis

ERIC Educational Resources Information Center

Tyndorf, Darryl M., Jr.; Glass, Chris R.

2017-01-01

Developing countries have significantly expanded efforts to import more flexible short-cycle institutions based on the United States community college model. The U.S. community college model addresses human capital needs of the labor market in developing countries by increasing access to an affordable education. However, there is limited research…

Nuclear materials safeguards for the future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tape, J.W.

Basic concepts of domestic and international safeguards are described, with an emphasis on safeguards systems for the fuel cycles of commercial power reactors. Future trends in institutional and technical measures for nuclear materials safeguards are outlined. The conclusion is that continued developments in safeguards approaches and technology, coupled with institutional measures that facilitate the global management and protection of nuclear materials, are up to the challenge of safeguarding the growing inventories of nuclear materials in commercial fuel cycles in technologically advanced States with stable governments that have signed the nonproliferation treaty. These same approaches also show promise for facilitating internationalmore » inspection of excess weapons materials and verifying a fissile materials cutoff convention.« less

Exploring Home Economics Related Careers. Introduction to Vocations.

ERIC Educational Resources Information Center

Hoggatt, Carolyn, Ed.

Developed to meet the career educational needs of students enrolled in home economics courses and/or an introductory vocational program, this document (teacher's copy) contains six units of study focusing on the home economics related careers cycles of: child development and care; clothing, textiles and fashion; food services; institutional,…

NREL: U.S. Life Cycle Inventory Database - Related Links

Science.gov Websites

) information, LCA tools, research institutes utilizing LCA, labeling initiatives and organizations , international LCA initiatives, LCA online forums. Life Cycle Inventory Data Ecoinvent: Swiss Centre for Life Institute for Environmental Research and Education): The American Center for Life Cycle Assessment SETAC

A model for a knowledge-based system's life cycle

NASA Technical Reports Server (NTRS)

Kiss, Peter A.

1990-01-01

The American Institute of Aeronautics and Astronautics has initiated a Committee on Standards for Artificial Intelligence. Presented here are the initial efforts of one of the working groups of that committee. The purpose here is to present a candidate model for the development life cycle of Knowledge Based Systems (KBS). The intent is for the model to be used by the Aerospace Community and eventually be evolved into a standard. The model is rooted in the evolutionary model, borrows from the spiral model, and is embedded in the standard Waterfall model for software development. Its intent is to satisfy the development of both stand-alone and embedded KBSs. The phases of the life cycle are detailed as are and the review points that constitute the key milestones throughout the development process. The applicability and strengths of the model are discussed along with areas needing further development and refinement by the aerospace community.

A puzzle used to teach the cardiac cycle.

PubMed

Marcondes, Fernanda K; Moura, Maria J C S; Sanches, Andrea; Costa, Rafaela; de Lima, Patricia Oliveira; Groppo, Francisco Carlos; Amaral, Maria E C; Zeni, Paula; Gaviao, Kelly Cristina; Montrezor, Luís H

2015-03-01

The aim of the present article is to describe a puzzle developed for use in teaching cardiac physiology classes. The puzzle presents figures of phases of the cardiac cycle and a table with five columns: phases of cardiac cycle, atrial state, ventricular state, state of atrioventricular valves, and pulmonary and aortic valves. Chips are provided for use to complete the table. Students are requested to discuss which is the correct sequence of figures indicating the phases of cardiac cycle. Afterward, they should complete the table with the chips. Students of biology, dentistry, medicine, pharmacy, and nursing graduation courses from seven institutions performed the puzzle evaluation. They were invited to indicate whether the puzzle had been useful for learning about the subject by filling one of four alternatives. Of the students, 4.6% answered that it was not necessary but helped them to confirm what they had learned, 64.5% reported that although they had previously understood the cardiac cycle, the puzzle helped them to solve doubts and promoted a better understanding of it, and 30.9% said that they needed the puzzle to understand the cardiac cycle, without differences among courses, institutions, and course semesters. The results of the present study suggest that a simple and inexpensive puzzle may be useful as an active learning methodology applied after the theoretical lecture, as a complementary tool for studying cardiac cycle physiology. Copyright © 2015 The American Physiological Society.

Establishing a Consortium for the Study of Rare Diseases: The Urea Cycle Disorders Consortium

PubMed Central

Seminara, Jennifer; Tuchman, Mendel; Krivitzky, Lauren; Krischer, Jeffrey; Lee, Hye-Seung; LeMons, Cynthia; Baumgartner, Matthias; Cederbaum, Stephen; Diaz, George A.; Feigenbaum, Annette; Gallagher, Renata C.; Harding, Cary O.; Kerr, Douglas S.; Lanpher, Brendan; Lee, Brendan; Lichter-Konecki, Uta; McCandless, Shawn E.; Merritt, J. Lawrence; Oster-Granite, Mary Lou; Seashore, Margretta R.; Stricker, Tamar; Summar, Marshall; Waisbren, Susan; Yudkoff, Marc; Batshaw, Mark L.

2010-01-01

The Urea Cycle Disorders Consortium (UCDC) was created as part of a larger network established by the National Institutes of Health to study rare diseases. This paper reviews the UCDC’s accomplishments over the first six years, including how the Consortium was developed and organized, clinical research studies initiated, and the importance of creating partnerships with patient advocacy groups, philanthropic foundations and biotech and pharmaceutical companies. PMID:20188616

Using Quality Enhancement Processes to Achieve Sustainable Development and Support for Sessional Staff

ERIC Educational Resources Information Center

Lekkas, D.; Winning, T. A.

2017-01-01

Consistent with quality enhancement, we report on how we used a continuous improvement cycle to formalise and embed an academic development and support programme for our School's sessional staff. Key factors in establishing and maintaining the programme included: local change agents supported initially by institutional project funding; School…

Institutional Planning as a Participative Process: A Community College Self Study.

ERIC Educational Resources Information Center

Sturtz, Alan J.

In 1981, South Central Community College received funding to develop a long-range planning process. The process was to be modeled on the 3-year planning cycle developed by the National Center for Higher Education Management Systems and to use the college's existing organizational structure. Since November 1981, the planning process at the college…

Academic Program Life Cycle: A Redefined Approach to Understanding Market Demands

ERIC Educational Resources Information Center

Mukerji, Siran; Tripathi, Purnendu

2004-01-01

Education can develop intellectual capability in people, which may in turn lead toward development of a more humane society. Open and distance learning (ODL) has provided one means of achieving social objectives democratically. In India significant success has been achieved through a network of 10 open universities and 104 institutes of open and…

Technology-Driven Planning: Principles to Practice.

ERIC Educational Resources Information Center

Boettcher, Judith V., Ed.; Doyle, Mary M., Ed.; Jensen, Richard W., Ed.

The selections in this collection explore topics related to the future of information technology and strategic, academic, resource, and facilities planning in institutions of higher education. Part 1, "Developing the Vision: Principles, Paradigms, Life Cycles, and Values," contains: (1) "Mega-Level Strategic Planning: Beyond Conventional Wisdom"…

75 FR 5601 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-03

... Mouse Models for Cytogenetic Disorders. Date: February 16, 2010. Time: 2 p.m. to 3 p.m. Agenda: To... to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of...

Perimenarchal air pollution exposure and menstrual disorders.

PubMed

Mahalingaiah, S; Missmer, S E; Cheng, J J; Chavarro, J; Laden, F; Hart, J E

2018-01-25

What is the association between perimenarchal exposure to total suspended particulate (TSP) in air, menstrual irregularity phenotypes and time to menstrual cycle regularity? Exposures to TSP during high school are associated with slightly increased odds of menstrual irregularity and longer time to regularity in high school and early adulthood. The menstrual cycle is responsive to hormonal regulation. Particulate matter air pollution has demonstrated hormonal activity. However, it is not known if air pollution is associated with menstrual cycle regularity. Cross sectional study of 34 832 of the original 116 430 women (29.91%) enrolled in 1989 from the Nurses' Health Study II (NHSII). The follow-up rate for this analytic sample was 97.76% at the 1991 survey. Annual averages of TSP were available for each year of high school attendance. We created three case definitions including high school menstrual irregularity and androgen excess. The time to menstrual cycle regularity was reported by participants as <1 year, 1-2 years, 3-4 years, 5 years or longer, or never on the baseline questionnaire. Odds ratios and 95% confidence intervals (CI) were calculated for 45 μg/m3 increases in TSP exposure, adjusted for risk factors for menstrual irregularity. In multivariable adjusted models, we observed that for every 45 μg/m3 increase in average high school TSP there was an increased odds (95%CI) of 1.08 (1.03-1.14), 1.08 (1.02-1.15) and 1.10 (0.98-1.25) for moderate, persistent, and persistent with androgen excess irregularity phenotypes, respectively. TSP was also associated with a longer time to cycle regularity, with stronger results among women with older ages at menarche and those living in the Northeast or the West. The outcomes of menstrual regularity and time to cycle regularity were retrospectively assessed outcomes and may be susceptible to recall bias. There is also the potential for selection bias, as women had to live until 2011 to provide addresses. Temporal exposure to air pollution in the adolescent and early adulthood window may be especially important, given its association with phenotypes of menstrual irregularity. The data from this study agrees with existing literature regarding air pollution and reproductive tract diseases. Shruthi Mahalingaiah: Reproductive Scientist Development Program HD000849, and a research grant from the Boston University Department of Obstetrics and Gynecology, Stacey Missmer: R01HD57210 from the National Institute of Child Health and Human Development and the Massachusetts Institute of Technology Center for Environmental Health Sciences Translational Pilot Project Program, R01CA50385 from the National Cancer Institute, Jaime Hart and Francine Laden: 5R01ES017017 from the National Institute for Environmental Health Sciences, Jaime Hart: P30 ES00002 from the National Institute for Environmental Health Sciences at the National Institute of Health, The Nurses' Health Study II is supported by infrastructure grant UM1CA176726 from the National Cancer Institute, NIH, U.S. Department of Health and Human Services The authors have no conflicts of interest to declare. © The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

A hybrid water-splitting cycle using copper sulfate and mixed copper oxides

NASA Technical Reports Server (NTRS)

Schreiber, J. D.; Remick, R. J.; Foh, S. E.; Mazumder, M. M.

1980-01-01

The Institute of Gas Technology has derived and developed a hybrid thermochemical water-splitting cycle based on mixed copper oxides and copper sulfate. Similar to other metal oxide-metal sulfate cycles that use a metal oxide to 'concentrate' electrolytically produced sulfuric acid, this cycle offers the advantage of producing oxygen (to be vented) and sulfur dioxide (to be recycled) in separate steps, thereby eliminating the need of another step to separate these gases. The conceptual process flow-sheet efficiency of the cycle promises to exceed 50%. It has been completely demonstrated in the laboratory with recycled materials. Research in the electrochemical oxidation of sulfur dioxide to produce sulfuric acid and hydrogen performed at IGT indicates that the cell performance goals of 200 mA/sq cm at 0.5 V will be attainable using relatively inexpensive electrode materials.

Long Waves and Journalism Ideology in America, 1835-1985.

ERIC Educational Resources Information Center

Kaul, Arthur J.; McKerns, Joseph P.

Framed by the heuristic device of "long waves" of capitalist development, journalism ideology is historically anchored to competitive media economics. (Long waves are 50-year economic cycles comprised of alternating 25-year periods of economic expansion followed by contraction periods.) With each long wave, a new institutional ecology…

Key Challenges to Collegiate Music Education Programs in North America

ERIC Educational Resources Information Center

Jones, Patrick M.

2012-01-01

Higher education is the linchpin of music education in North America. It is primarily in collegiate institutions that music teachers are educated throughout the life cycles of their careers. This begins with preservice programs, typically at the baccalaureate level, and continues with in-service professional development and graduate degree…

Management Information Systems for Higher Education. Studies in Institutional Management in Higher Education.

ERIC Educational Resources Information Center

Hussain, K. M., Ed.

Contents include an introduction to information systems (basic concepts and life-cycle); development of an information system (design, implementation, testing, and conversion); operation (evaluation and maintenance, quality control, and economics); and case studies of such systems at the New University of Lisbon, Bath University, Laval University…

Environmental Scan: 1993-94 Planning/Budgeting Cycle.

ERIC Educational Resources Information Center

Sinclair Community Coll., Dayton, OH. Office of Institutional Planning and Research.

In the past, environmental scanning reports produced by Sinclair Community College (SCC) in Ohio were designed to provide a brief, eclectic, and provocative overview of major trends and issues likely to influence the development of the institution during the upcoming fiscal year. The 1993 Environmental Scan report speculates about long-term…

The 2nd State of the Carbon Cycle Report (SOCCR-2): Process, Progress and Institutional Context

NASA Astrophysics Data System (ADS)

Shrestha, G.; Cavallaro, N.; Zhu, Z.; Larson, E. K.; Butler, J. H.

2017-12-01

Over 200 scientists and program managers from U.S., Mexican and Canadian government and non-government institutions have been collaborating on SOCCR-2 since 2015. Responding to the U.S. Global Change Research Act (1990) and the U.S. Carbon Cycle Science Plan (2011), this special Sustained National Climate Assessment report covers many of the GCRA mandated sectors such as agriculture, energy, forestry, aquatic systems, coasts, wetlands, atmospheric and human social systems, integrating the scientific uncertainties and analyzing the effects of global change on the carbon cycle and vice versa, including projections for both human- induced and natural changes. This presentation covers the SOCCR-2 process, progress and institutional context, providing a historical perspective on the interagency instruments and mechanisms that have facilitated the last decades of carbon cycle science reflected in SOCCR-2.

Exploring Institutional Mechanisms for Scientific Input into the Management Cycle of the National Protected Area Network of Peru: Gaps and Opportunities.

PubMed

López-Rodríguez, M D; Castro, H; Arenas, M; Requena-Mullor, J M; Cano, A; Valenzuela, E; Cabello, J

2017-12-01

Understanding how to improve decision makers' use of scientific information across their different scales of management is a core challenge for narrowing the gap between science and conservation practice. Here, we present a study conducted in collaboration with decision makers that aims to explore the functionality of the mechanisms for scientific input within the institutional setting of the National Protected Area Network of Peru. First, we analyzed institutional mechanisms to assess the scientific information recorded by decision makers. Second, we developed two workshops involving scientists, decision makers and social actors to identify barriers to evidence-based conservation practice. Third, we administered 482 questionnaires to stakeholders to explore social perceptions of the role of science and the willingness to collaborate in the governance of protected areas. The results revealed that (1) the institutional mechanisms did not effectively promote the compilation and application of scientific knowledge for conservation practice; (2) six important barriers hindered scientific input in management decisions; and (3) stakeholders showed positive perceptions about the involvement of scientists in protected areas and expressed their willingness to collaborate in conservation practice. This collaborative research helped to (1) identify gaps and opportunities that should be addressed for increasing the effectiveness of the institutional mechanisms and (2) support institutional changes integrating science-based strategies for strengthening scientific input in decision-making. These insights provide a useful contextual orientation for scholars and decision makers interested in conducting empirical research to connect scientific inputs with operational aspects of the management cycle in other institutional settings around the world.

Exploring Institutional Mechanisms for Scientific Input into the Management Cycle of the National Protected Area Network of Peru: Gaps and Opportunities

NASA Astrophysics Data System (ADS)

López-Rodríguez, M. D.; Castro, H.; Arenas, M.; Requena-Mullor, J. M.; Cano, A.; Valenzuela, E.; Cabello, J.

2017-12-01

Understanding how to improve decision makers' use of scientific information across their different scales of management is a core challenge for narrowing the gap between science and conservation practice. Here, we present a study conducted in collaboration with decision makers that aims to explore the functionality of the mechanisms for scientific input within the institutional setting of the National Protected Area Network of Peru. First, we analyzed institutional mechanisms to assess the scientific information recorded by decision makers. Second, we developed two workshops involving scientists, decision makers and social actors to identify barriers to evidence-based conservation practice. Third, we administered 482 questionnaires to stakeholders to explore social perceptions of the role of science and the willingness to collaborate in the governance of protected areas. The results revealed that (1) the institutional mechanisms did not effectively promote the compilation and application of scientific knowledge for conservation practice; (2) six important barriers hindered scientific input in management decisions; and (3) stakeholders showed positive perceptions about the involvement of scientists in protected areas and expressed their willingness to collaborate in conservation practice. This collaborative research helped to (1) identify gaps and opportunities that should be addressed for increasing the effectiveness of the institutional mechanisms and (2) support institutional changes integrating science-based strategies for strengthening scientific input in decision-making. These insights provide a useful contextual orientation for scholars and decision makers interested in conducting empirical research to connect scientific inputs with operational aspects of the management cycle in other institutional settings around the world.

Institutional Context of Carbon Cycle Science Research in the U.S. and North America - A SOCCR perspective

NASA Astrophysics Data System (ADS)

Shrestha, G.; Cavallaro, N.; Ste-Marie, C.

2016-12-01

Carbon cycle science has been a research priority in the U.S. for decades. Interagency coordination interests and research needs in U.S. carbon cycle science led to the establishment of the U.S. Carbon Cycle Science Program, the North American Carbon Program (NACP), the Ocean Carbon and Biogeochemistry Program (OCB) and other intergovernmental collaboration platforms such as CarboNA, involving the U.S., Mexico and Canada. This presentation highlights some of these activities, and the historical context, the institutional frameworks and the operational mechanisms that have helped to facilitate and advance large scale collaborative research in carbon cycle in the U.S. and North America.

Nuclear proliferation-resistance and safeguards for future nuclear fuel cycle

NASA Astrophysics Data System (ADS)

Kuno, Y.; Inoue, N.; Senzaki, M.

2009-03-01

Corresponding to the world nuclear security concerns, future nuclear fuel cycle (NFC) should have high proliferation-resistance (PR) and physical protection (PP), while promotion of the peaceful use of the nuclear energy must not be inhibited. In order to accomplish nuclear non-proliferation from NFC, a few models of the well-PR systems should be developed so that international community can recognize them as worldwide norms. To find a good balance of 'safeguard-ability (so-called extrinsic measure or institutional barrier)' and 'impede-ability (intrinsic feature or technical barrier)' will come to be essential for NFC designers to optimize civilian nuclear technology with nuclear non-proliferation, although the advanced safeguards with high detectability can still play a dominant role for PR in the states complying with full institutional controls. Accomplishment of such goal in a good economic efficiency is a future key challenge.

Repositories for Research: Southampton's Evolving Role in the Knowledge Cycle

ERIC Educational Resources Information Center

Simpson, Pauline; Hey, Jessie

2006-01-01

Purpose: To provide an overview of how open access (OA) repositories have grown to take a premier place in the e-research knowledge cycle and offer Southampton's route from project to sustainable institutional repository. Design/methodology/approach: The evolution of institutional repositories and OA is outlined raising questions of multiplicity…

Breaking the Cycle of Poverty: Whole Family Approach

ERIC Educational Resources Information Center

Bernard van Leer Foundation, 2016

2016-01-01

"The demographics of families in poverty around the globe may be diverse, but parents' dreams for their children are similar everywhere: good health, a good education, economic stability, and a better future." This new report from the Bernard van Leer Foundation and Ascend at The Aspen Institute develops a "two generation"…

Strategic Decision Making Cycle in Higher Education: Case Study of E-Learning

ERIC Educational Resources Information Center

Divjak, Blaženka; Redep, Nina Begicevic

2015-01-01

This paper presents the methodology for strategic decision making in higher education (HE). The methodology is structured as a cycle of strategic decision making with four phases, and it is focused on institutional and national perspective, i.e. on decision making that takes place at institutions of HE and relevant national authorities, in case…

Artificial Intelligence Software Engineering (AISE) model

NASA Technical Reports Server (NTRS)

Kiss, Peter A.

1990-01-01

The American Institute of Aeronautics and Astronautics has initiated a committee on standards for Artificial Intelligence. Presented are the initial efforts of one of the working groups of that committee. A candidate model is presented for the development life cycle of knowledge based systems (KBSs). The intent is for the model to be used by the aerospace community and eventually be evolved into a standard. The model is rooted in the evolutionary model, borrows from the spiral model, and is embedded in the standard Waterfall model for software development. Its intent is to satisfy the development of both stand-alone and embedded KBSs. The phases of the life cycle are shown and detailed as are the review points that constitute the key milestones throughout the development process. The applicability and strengths of the model are discussed along with areas needing further development and refinement by the aerospace community.

Turning science into health solutions: KEMRI’s challenges as Kenya’s health product pathfinder

PubMed Central

2010-01-01

Background A traditional pathway for developing new health products begins with public research institutes generating new knowledge, and ends with the private sector translating this knowledge into new ventures. But while public research institutes are key drivers of basic research in sub-Saharan Africa, the private sector is inadequately prepared to commercialize ideas that emerge from these institutes, resulting in these institutes taking on the role of product development themselves to alleviate the local disease burden. In this article, the case study method is used to analyze the experience of one such public research institute: the Kenya Medical Research Institute (KEMRI). Discussion Our analysis indicates that KEMRI’s product development efforts began modestly, and a manufacturing facility was constructed with a strategy for the facility’s product output which was not very successful. The intended products, HIV and Hepatitis B diagnostic kits, had a short product life cycle, and an abrupt change in regulatory requirements left KEMRI with an inactive facility. These problems were the result of poor innovation management capacity, variability in domestic markets, lack of capital to scale up technologies, and an institutional culture that lacked innovation as a priority. However, KEMRI appears to have adapted by diversifying its product line to mitigate risk and ensure continued use of its manufacturing facility. It adopted an open innovation business model which linked it with investors, research partnerships, licensing opportunities, and revenue from contract manufacturing. Other activities that KEMRI has put in place over several years to enhance product development include the establishment of a marketing division, development of an institutional IP policy, and training of its scientists on innovation management. Summary KEMRI faced many challenges in its attempt at health product development, including shifting markets, lack of infrastructure, inadequate financing, and weak human capital with respect to innovation. However, it overcame them through diversification, partnerships and changes in culture. The findings could have implications for other research institutes in Sub-Saharan Africa seeking to develop health products. Such institutes must analyze potential demand and uptake, yet be prepared to face the unexpected and develop appropriate risk-mitigating strategies. PMID:21144070

Turning science into health solutions: KEMRI's challenges as Kenya's health product pathfinder.

PubMed

Simiyu, Ken; Masum, Hassan; Chakma, Justin; Singer, Peter A

2010-12-13

A traditional pathway for developing new health products begins with public research institutes generating new knowledge, and ends with the private sector translating this knowledge into new ventures. But while public research institutes are key drivers of basic research in sub-Saharan Africa, the private sector is inadequately prepared to commercialize ideas that emerge from these institutes, resulting in these institutes taking on the role of product development themselves to alleviate the local disease burden. In this article, the case study method is used to analyze the experience of one such public research institute: the Kenya Medical Research Institute (KEMRI). Our analysis indicates that KEMRI's product development efforts began modestly, and a manufacturing facility was constructed with a strategy for the facility's product output which was not very successful. The intended products, HIV and Hepatitis B diagnostic kits, had a short product life cycle, and an abrupt change in regulatory requirements left KEMRI with an inactive facility. These problems were the result of poor innovation management capacity, variability in domestic markets, lack of capital to scale up technologies, and an institutional culture that lacked innovation as a priority.However, KEMRI appears to have adapted by diversifying its product line to mitigate risk and ensure continued use of its manufacturing facility. It adopted an open innovation business model which linked it with investors, research partnerships, licensing opportunities, and revenue from contract manufacturing. Other activities that KEMRI has put in place over several years to enhance product development include the establishment of a marketing division, development of an institutional IP policy, and training of its scientists on innovation management. KEMRI faced many challenges in its attempt at health product development, including shifting markets, lack of infrastructure, inadequate financing, and weak human capital with respect to innovation. However, it overcame them through diversification, partnerships and changes in culture. The findings could have implications for other research institutes in Sub-Saharan Africa seeking to develop health products. Such institutes must analyze potential demand and uptake, yet be prepared to face the unexpected and develop appropriate risk-mitigating strategies.

The application of Legacy Cycles in the development of Earth Science curriculum

NASA Astrophysics Data System (ADS)

Ellins, K.; Abernathy, E.; Negrito, K.; McCall, L.

2009-04-01

The Institute for Geophysics in the Jackson School of Geosciences at The University of Texas at Austin actively contributes to K-12 education, including the development of rigorous Earth and Space Science curriculum designed for secondary school learning environments. Here we report on our efforts to apply an innovative new pedagogical approach, the Legacy Cycle, to scientific ocean drilling paleoclimate data from fossil corals collected offshore Barbados in 2006 and to the creation of a high school water resources education program for Texas high school students supported by a grant from the Texas Water Development Board. The Legacy Cycle makes use of the Internet and computer technology to engage students in extended inquiry learning. A series of inquiry activities are organized around a set of three driving questions, or challenges. Students mimic the work of scientists by generating ideas to address a given challenge, listening to multiple perspectives from experts on the topic, researching a set of sub-questions and revising their original ideas, testing their mettle with labs and quizzes, and finally composing a project or paper that answers the original challenge. The technology makes it easy for students to move through the challenges and the organizational framework since there are hyperlinks to each of the sections (and to reach the other challenges) at the bottom of each webpage. Students' final work is posted to the Internet for others to see, and in this way they leave behind their legacy. Our Legacy Cycle activities use authentic hydrologic, water quality, geochemical, geophysical data, as well as remotely sensed data such as is collected by satellites. They are aligned with the U.S. National Science Education Standards, the new Ocean, Climate and Earth Science Literacy Principles (in development), and the Texas Essential Knowledge and Skills for Earth and Space Science. The work represents a collaboration involving teachers from The University of Texas' UTeach program, the NSF-sponsored Texas Earth and Space Science (TXESS) Revolution program of teacher professional development, and the Texas Regional Collaboratives for Excellence in Science and Mathematics Teaching, and scientists from the Institute for Geophysics, the Lamont-Doherty Earth Observatory and the Texas Water Development Board.

Examining Teachers' Understanding of the Mathematical Learning Progression through Vertical Articulation during Lesson Study

ERIC Educational Resources Information Center

Suh, Jennifer; Seshaiyer, Padmanabhan

2015-01-01

This study examines elementary- and middle-grade teachers' understanding of the mathematical learning progression as they participated in a 6-month professional learning project. Teachers participated in a professional development project that consisted of a 1-week summer content-focused institute with school-based follow-up Lesson Study cycles in…

LCA Study for Pilot Scale Production of Cellulose Nano Crystals (CNC) from Wood Pulp

Treesearch

Hongmei Gu; Richard Reiner; Richard Bergman; Alan Rudie

2015-01-01

Interest in cellulose nanocrystals (CNC)/cellulose nanofibrils (CNF) made from woody biomass has been growing rapidly with close attention from pulp and paper industry, governments, universities, and research institutes. Many new products development with CNCs have been studied intensively. However, little life-cycle analysis (LCA) has been conducted for the...

IEEE Computer Society/Software Engineering Institute Software Process Achievement (SPA) Award 2009

DTIC Science & Technology

2011-03-01

capabilities to our GDM. We also introduced software as a service ( SaaS ) as part our technology solutions and have further enhanced our ability to...model PROSPER Infosys production support methodology Q&P quality and productivity R&D research and development SaaS software as a service ... Software Development Life Cycle (SDLC) 23 Table 10: Scientific Estimation Coverage by Service Line 27 CMU/SEI-2011-TR-008 | vi CMU/SEI-2011

Arterial signal timing optimization using PASSER II-87

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, E.C.P.; Messer, C.J.; Garza, R.U.

1988-11-01

PASSER is the acronym for the Progression Analysis and Signal System Evaluation Routine. PASSER II was originally developed by the Texas Transportation Institute (TTI) for the Dallas Corridor Project. The Texas State Department of Highways and Public Transportation (SDHPT) has sponsored the subsequent program development on both mainframe computers and microcomputers. The theory, model structure, methodology, and logic of PASSER II have been evaluated and well documented. PASSER II is widely used because of its ability to easily select multiple-phase sequences by adjusting the background cycle length and progression speeds to find the optimal timing plants, such as cycle, greenmore » split, phase sequence, and offsets, that can efficiently maximize the two-way progression bands.« less

Benchmarks: Reports of the NASA Science Institutes Team

NASA Technical Reports Server (NTRS)

Diaz, A. V.

1995-01-01

This report results from a benchmarking study undertaken by NASA as part of its planning for the possible creation of new science Institutes. Candidate Institutes under consideration cover a range of scientific and technological activities ranging from biomedical to astrophysical research and from the global hydrological cycle to microgravity material science. Should NASA create these Institutes, the intent will be to preserve and strengthen key science and technology activities now being performed by Government employees at NASA Field Centers. Because the success of these projected non-Government-operated Institutes is vital for the continued development of space science and applications, NASA has sought to identify the best practices of successful existing scientific and technological research institutions as they carry out those processes that will be most important for the new science Institutes. While many individuals and organizations may be interested in our findings, the primary use of this report will be to formulate plas for establishing the new science Institutes. As a result, the report is organized to that the "best practices" of the finest institutes are associated with characteristics of all institutes. These characteristics or "attributes" serve as the headings for the main body of this report.

The influence of sporadic anovulation on hormone levels in ovulatory cycles

PubMed Central

Hambridge, H.L.; Mumford, S.L.; Mattison, D.R.; Ye, A.; Pollack, A.Z.; Bloom, M.S.; Mendola, P.; Lynch, K.L.; Wactawski-Wende, J.; Schisterman, E.F.

2013-01-01

STUDY QUESTION Do ovulatory hormone profiles among healthy premenopausal women differ between women with and without sporadic anovulation? SUMMARY ANSWER Women with one anovulatory cycle tended to have lower estradiol, progesterone and LH peak levels during their ovulatory cycle. WHAT IS KNOWN ALREADY Anovulation occurs sporadically in healthy premenopausal women, but the influence of hormones in a preceding cycle and the impact on a subsequent cycle's hormone levels is unknown. STUDY DESIGN, SIZE, DURATION The BioCycle Study was a prospective cohort including 250 healthy regularly menstruating women, 18–44 years of age, from Western New York with no history of menstrual or ovulation disorders. The women were followed with up to eight study visits per cycle for two cycles, most of which were consecutive. PARTICIPANTS/MATERIALS, SETTING AND METHODS All study visits were timed to menstrual cycle phase using fertility monitors and located at the University at Buffalo women's health research center from 2005 to 2007. The main outcomes measured were estradiol, progesterone, LH and follicle-stimulating hormone levels in serum at up to 16 visits over two cycles. Anovulation was defined as peak serum progesterone concentrations ≤5 ng/ml and no serum LH peak detected during the mid- or late-luteal phase visit. MAIN RESULTS AND THE ROLE OF CHANCE Reproductive hormone concentrations were lower during anovulatory cycles, but significant reductions were also observed in estradiol (−25%, P = 0.003) and progesterone (−22%, P = 0.001) during the ovulatory cycles of women with one anovulatory cycle compared with women with two ovulatory cycles. LH peak concentrations were decreased in the ovulatory cycle of women with an anovulatory cycle (significant amplitude effect, P = 0.004; geometric mean levels 38% lower, P < 0.05). LIMITATIONS, REASONS FOR CAUTION Follow-up was limited to two menstrual cycles, and no ultrasound assessment of ovulation was available. Data were missing for a total of 168 of a possible 4072 cycle visits (4.1%), though all women had at least five visits per cycle (94% had seven or more per cycle). WIDER IMPLICATIONS OF THE FINDINGS These results suggest a possible underlying cause of anovulation, such as a longer-term subclinical follicular, ovarian or hypothalamic/pituitary dysfunction, even among healthy, regularly menstruating women. STUDY FUNDING/COMPETING INTERESTS This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (Contract no. HHSN275200403394C). The authors have no potential competing interests. PMID:23589536

Aircraft stress sequence development: A complex engineering process made simple

NASA Technical Reports Server (NTRS)

Schrader, K. H.; Butts, D. G.; Sparks, W. A.

1994-01-01

Development of stress sequences for critical aircraft structure requires flight measured usage data, known aircraft loads, and established relationships between aircraft flight loads and structural stresses. Resulting cycle-by-cycle stress sequences can be directly usable for crack growth analysis and coupon spectra tests. Often, an expert in loads and spectra development manipulates the usage data into a typical sequence of representative flight conditions for which loads and stresses are calculated. For a fighter/trainer type aircraft, this effort is repeated many times for each of the fatigue critical locations (FCL) resulting in expenditure of numerous engineering hours. The Aircraft Stress Sequence Computer Program (ACSTRSEQ), developed by Southwest Research Institute under contract to San Antonio Air Logistics Center, presents a unique approach for making complex technical computations in a simple, easy to use method. The program is written in Microsoft Visual Basic for the Microsoft Windows environment.

On the Creation, Utility and Sustaining of Rare Diseases Research Networks: Lessons learned from the Urea Cycle Disorders Consortium, the Japanese Urea Cycle Disorders Consortium and the European Registry and Network for Intoxication Type Metabolic Diseases.

PubMed

Summar, Marshall L; Endo, Fumio; Kölker, Stefan

2014-01-01

The past two decades has seen a rapid expansion in the scientific and public interest in rare diseases and their treatment. One consequence of this has been the formation of registries/longitudinal natural history studies for these disorders. Given the expense and effort needed to develop and maintain such programs, we describe our experience with three linked registries on the same disease group, urea cycle disorders. The Urea Cycle Disorders Consortium (UCDC) was formed in the U.S. in 2003 in response to a request for application from the National Institutes of Health (NIH); the European Registry and Network for Intoxication Type Metabolic Diseases (E-IMD) was formed in 2011 in response to a request for applications from the Directorate-General for Health and Consumers (DG SANCO) of the EU; and the Japanese Urea Cycle Disorders Consortium (JUCDC) was founded in 2012 as a sister organization to the UCDC and E-IMD. The functions of these groups are to collect natural history data, educate the professional and lay population, develop and test new treatments, and establish networks of excellence for the care for these disorders. The UCDC and JUCDC focus exclusively on urea cycle disorders while the E-IMD includes patients with urea cycle disorders and organic acidurias. More than 1400 patients have been enrolled in the three consortia, and numerous projects have been developed and joint meetings held including an international UCDC/E-IMD/JUCDC Urea Cycle meeting in Barcelona in 2013. This article summarizes some of the experiences from the three groups regarding formation, funding, and models for sustainability. Copyright © 2014 Elsevier Inc. All rights reserved.

On the Creation, Utility and Sustaining of Rare Diseases Research Networks: Lessons learned from the Urea Cycle Disorders Consortium, the Japanese Urea Cycle Disorders Consortium and the European Registry and Network for Intoxication Type Metabolic Diseases

PubMed Central

Summar, Marshall L.; Endo, Fumio; Kölker, Stefan

2016-01-01

The past two decades has seen a rapid expansion in the scientific and public interest in rare diseases and their treatment. One consequence of this has been the formation of registries/longitudinal natural history studies for these disorders. Given the expense and effort needed to develop and maintain such programs, we describe our experience with three linked registries on the same disease group, urea cycle disorders. The Urea Cycle Disorders Consortium (UCDC) was formed in the U.S. in 2003 in response to a request for application from the National Institutes of Health (NIH); the European Registry and Network for Intoxication Type Metabolic Diseases (E-IMD) was formed in 2011 in response to a request for applications from the Directorate-General for Health and Consumers (DG SANCO) of the EU; and the Japanese Urea Cycle Disorders Consortium (JUCDC) was founded in 2012 as a sister organization to the UCDC and E-IMD. The functions of these groups are to collect natural history data, educate the professional and lay population, develop and test new treatments, and establish networks of excellence for the care for these disorders. The UCDC and JUCDC focus exclusively on urea cycle disorders while the E-IMD includes patients with urea cycle disorders and organic acidurias. More than 1400 patients have been enrolled in the three consortia, and numerous projects have been developed and joint meetings held including an international UCDC/E-IMD/JUCDC Urea Cycle meeting in Barcelona in 2013. This article summarizes some of the experiences from the three groups regarding formation, funding, and models for sustainability. PMID:25261246

Performance and durability testing of parabolic trough receivers

NASA Astrophysics Data System (ADS)

Lei, Dongqiang; Fu, Xuqiang; Zhao, Dongming; Yuan, Guofeng; Wang, Zhifeng; Guo, Minghuan

2017-06-01

The paper describes the key performance and durability testing facilities of the parabolic trough receiver developed by Institute of Electrical Engineering, Chinese Academy of Sciences. The indoor heat loss test can be applied at 4-7 different temperature levels within 200-550 on receivers. The optical efficiency test bench consists of 12 metal halide lamps as the solar simulator and a 5 m length half-elliptical cylinder reflector with flat end reflectors. 3 ultra-precision temperature sensors are used in receiver each end to get the temperature difference. The residual gas analysis test bench is applied to analyze and predict the vacuum lifetime of the receiver. It can test the variations of composition and partial pressure of residual gases with temperature and time in the receiver annulus space by a high sensitivity quadrupole mass spectrometer gas analyzer. A coating accelerated ageing test bench, which is also used to test the thermal cycle, has been developed. This test bench uses the absorber tube of the recevier as the resistance heater to heat up the whole receiver. The coating lifetime can be predicted by the Arrhenius parameters. For the cycling test, the compressed air is used to directly cool the inner surface of the absorber tube. The thermal cycling test is performed with temperature cycles from 150 °C to 450 °C for 160 cycles. The maximum thermal cycling frequency is 8 cycles per day. The mechanical fatigue test bench is used to test the bellows and the glass-to-metal seals durability at the same time. Both bellows are expanded and compressed to 6.5 mm in turn with 10,000 cycles. A new rotating test bench was also developed to test the thermal efficiency of the receiver.

Managing Fault Management Development

NASA Technical Reports Server (NTRS)

McDougal, John M.

2010-01-01

As the complexity of space missions grows, development of Fault Management (FM) capabilities is an increasingly common driver for significant cost overruns late in the development cycle. FM issues and the resulting cost overruns are rarely caused by a lack of technology, but rather by a lack of planning and emphasis by project management. A recent NASA FM Workshop brought together FM practitioners from a broad spectrum of institutions, mission types, and functional roles to identify the drivers underlying FM overruns and recommend solutions. They identified a number of areas in which increased program and project management focus can be used to control FM development cost growth. These include up-front planning for FM as a distinct engineering discipline; managing different, conflicting, and changing institutional goals and risk postures; ensuring the necessary resources for a disciplined, coordinated approach to end-to-end fault management engineering; and monitoring FM coordination across all mission systems.

78 FR 67348 - Invitation for Public Comment on Draft Test Plan for the High Burnup Dry Storage Cask Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

... will be executed will be added when Dominion Virginia Power, who is part of the Electric Power research... Electric Power Research Institute (EPRI) to document what is planned to be accomplished by the CDP. DOE is... Storage Cask Research and Development Project (CDP) AGENCY: Fuel Cycle Technologies, Office of Nuclear...

IRIS: Supporting & Managing the Research Life-Cycle

ERIC Educational Resources Information Center

Bollini, Andrea; Mennielli, Michele; Mornati, Susanna; Palmer, David T.

2016-01-01

IRIS is a new Current Research Information System (CRIS) developed by Cineca to upgrade and replace two previous solutions that have been used by Italian universities in the last 10 years. At the end of 2015, sixty-three Italian institutions are using IRIS. One of the main components of IRIS is DSpace-CRIS, an open source solution that can also be…

The Role and Scope of Institutional Research in State University Planning and Budgeting. AIR Forum 1982 Paper.

ERIC Educational Resources Information Center

Freeman, Thomas M.; Kopf, Kathleen E.

A Multiphase Rolling Plan (MRP) implemented by the State University of New York to deal with declining percentages of state tax resources and projections for stabilized enrollments is described. For the preliminary budget cycle for fiscal year 1982-1983, academic and mission plans were linked to the annual budgeting process. Developed to ensure…

Engineering Margin Factors Used in the Design of the VVER Fuel Cycles

NASA Astrophysics Data System (ADS)

Lizorkin, M. P.; Shishkov, L. K.

2017-12-01

The article describes methods for determination of the engineering margin factors currently used to estimate the uncertainties of the VVER reactor design parameters calculated via the KASKAD software package developed at the National Research Center Kurchatov Institute. These margin factors ensure the meeting of the operating (design) limits and a number of other restrictions under normal operating conditions.

75 FR 80512 - National Institute on Drug Abuse; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis...D, Scientific Review Administrator, Office of Extramural Affairs, National Institute on Drug Abuse... limitations imposed by the review and funding cycle. Name of Committee: National Institute on Drug Abuse...

78 FR 56238 - National Institute on Drug Abuse; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel Multisite... Officer, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4234, MSC 9550... review and funding cycle. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; I...

75 FR 42104 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel Systems... Administrator, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 220, MSC 8401... review and funding cycle. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel 2010...

A summary of the recommendations adopted unanimously at the Fourth World Conference on Women (4-15 September 1995).

PubMed

1996-01-01

This article presents a summary of the platform of action recommendations adopted unanimously at the Fourth World Conference on Women in 1995. The Platform called for the empowerment of women; the protection of human rights and freedoms throughout the life cycle; and equity at home, at work, and abroad, items that reinforced the Beijing Declaration. This article identifies recommended actions on poverty, education and training, health, domestic violence, armed conflict, economy, decision-making, institutional mechanisms, human rights, mass media, environment, the girl-child, and institutional and financial arrangements. The Platform recommends, for example, action to create macroeconomic policies and development strategies that address the needs of women in poverty. It recommends changes in laws and administrative practices to ensure women's equal rights and access to economic resources. It recommends action to ensure equal access to education throughout the life cycle, to eradicate illiteracy among women, to develop nondiscriminatory education and training, and to allocate sufficient resources for educational reform. It recommends action to increase women's access throughout the life cycle to appropriate, affordable, and quality health care, information, and related services. Action should reduce maternal mortality by at least 50% of 1990 levels by the year 2000, and a further 50% by 2015. Legislation must be adopted to end violence against women in peace and wartime. Action must promote women's economic and human rights and women's equal access to and full participation in power structures and government decision-making.

Achieving Hand Hygiene Success With a Partnership Between Graduate Medical Education, Hospital Leadership, and Physicians.

PubMed

Rosenbluth, Glenn; Garritson, Susan; Green, Adrienne L; Milev, Dimiter; Vidyarthi, Arpana R; Auerbach, Andrew D; Baron, Robert B

2016-11-01

Engaging physicians in hand hygiene programs is a challenge faced by many academic medical centers. Partnerships between education and academic leaders present opportunities for effective collaboration and improvement. The authors developed a robust hand hygiene quality improvement program, with attention to rapid-cycle improvements, including all levels of staff and health care providers. The program included a defined governance structure, clear data collection process, educational interventions, rapid-cycle improvements, and financial incentive for staff and physicians (including residents and fellows). Outcomes were measured on patients in all clinical areas. Run charts were used to document compliance in aggregate and by subgroups throughout the project duration. Institutional targets were achieved and then exceeded, with sustained hand hygiene compliance >90%. Physician compliance lagged behind aggregate compliance but ultimately was sustained at a level exceeding the target. Successfully achieving the institutional goal required collaboration among all stakeholders. Physician-specific data and physician champions were essential to drive improvement. © The Author(s) 2015.

The NEWS Water Cycle Climatology

NASA Astrophysics Data System (ADS)

Rodell, M.; Beaudoing, H. K.; L'Ecuyer, T.; Olson, W. S.

2012-12-01

NASA's Energy and Water Cycle Study (NEWS) program fosters collaborative research towards improved quantification and prediction of water and energy cycle consequences of climate change. In order to measure change, it is first necessary to describe current conditions. The goal of the first phase of the NEWS Water and Energy Cycle Climatology project was to develop "state of the global water cycle" and "state of the global energy cycle" assessments based on data from modern ground and space based observing systems and data integrating models. The project was a multi-institutional collaboration with more than 20 active contributors. This presentation will describe the results of the water cycle component of the first phase of the project, which include seasonal (monthly) climatologies of water fluxes over land, ocean, and atmosphere at continental and ocean basin scales. The requirement of closure of the water budget (i.e., mass conservation) at various scales was exploited to constrain the flux estimates via an optimization approach that will also be described. Further, error assessments were included with the input datasets, and we examine these in relation to inferred uncertainty in the optimized flux estimates in order to gauge our current ability to close the water budget within an expected uncertainty range.

The NEWS Water Cycle Climatology

NASA Technical Reports Server (NTRS)

Rodell, Matthew; Beaudoing, Hiroko Kato; L'Ecuyer, Tristan; William, Olson

2012-01-01

NASA's Energy and Water Cycle Study (NEWS) program fosters collaborative research towards improved quantification and prediction of water and energy cycle consequences of climate change. In order to measure change, it is first necessary to describe current conditions. The goal of the first phase of the NEWS Water and Energy Cycle Climatology project was to develop "state of the global water cycle" and "state of the global energy cycle" assessments based on data from modern ground and space based observing systems and data integrating models. The project was a multi-institutional collaboration with more than 20 active contributors. This presentation will describe the results of the water cycle component of the first phase of the project, which include seasonal (monthly) climatologies of water fluxes over land, ocean, and atmosphere at continental and ocean basin scales. The requirement of closure of the water budget (i.e., mass conservation) at various scales was exploited to constrain the flux estimates via an optimization approach that will also be described. Further, error assessments were included with the input datasets, and we examine these in relation to inferred uncertainty in the optimized flux estimates in order to gauge our current ability to close the water budget within an expected uncertainty range.

Improvement of tritium accountancy technology for ITER fuel cycle safety enhancement

NASA Astrophysics Data System (ADS)

O'hira, S.; Hayashi, T.; Nakamura, H.; Kobayashi, K.; Tadokoro, T.; Nakamura, H.; Itoh, T.; Yamanishi, T.; Kawamura, Y.; Iwai, Y.; Arita, T.; Maruyama, T.; Kakuta, T.; Konishi, S.; Enoeda, M.; Yamada, M.; Suzuki, T.; Nishi, M.; Nagashima, T.; Ohta, M.

2000-03-01

In order to improve the safe handling and control of tritium for the ITER fuel cycle, effective in situ tritium accounting methods have been developed at the Tritium Process Laboratory in the Japan Atomic Energy Research Institute under one of the ITER-EDA R&D tasks. The remote and multilocation analysis of process gases by an application of laser Raman spectroscopy developed and tested could provide a measurement of hydrogen isotope gases with a detection limit of 0.3 kPa analytical periods of 120 s. An in situ tritium inventory measurement by application of a `self-assaying' storage bed with 25 g tritium capacity could provide a measurement with the required detection limit of less than 1% and a design proof of a bed with 100 g tritium capacity.

Fixedwing UAV soundings of the boundary layer during the ScaleX 2015 summer campaign in southern Germany

NASA Astrophysics Data System (ADS)

Philipp, Andreas; Groos, Alexander; Petersen, Erik; Bischoff, Julian; Szogs, Sebastian; Beck, Christoph; Hähner, Jörg; Jacobeit, Jucundus

2016-04-01

In order to examine the potential to close the local water cycle budget and to evaluate models on different scales (among other aims) a fleet of 6 fixed wing UAVs has been operated by the Institute for Geography and the Institute for Informatics of the University of Augsburg during the ScaleX measurement campaign of the KIT/IMK-IFU (Karlsruher Institut für Technologie/Institut für Meteorologie und Klimatologie, Garmisch Partenkirchen). The site is located in southern Germany in a rural, hilly landscape at a small catchment tributing to the Ammersee and equipped with several ground based and remote sensing hydrological instruments. In order to complement these instruments by in situ measurements of the boundary layer, three intensive observation periods (IOPs) for taking temperature and humidity profiles took place, each with a different set up in order to evaluate optimal operation modes. The UAVs are all operated by the open hardware Apogee autopilot and sensor controller developed by ENAC (Ecole Nationale de l'Aviation Civile, Toulouse) operated by the PPRZ open source software package. The first IOP (30.06.-01.07.2015) was an experiment to cover a small site of 500 by 500 meters (well-apointed with hydrological instruments) in a 24 hours period as dense as possible. Thus three simultaneous helical profile flights (radius 70 m) have been run at each full hour around three different centres with heights ranging up to 1000 m above ground level (with special permissions). During a second IOP (15.07.2015) it has been tried to increase the frequence of profile flights up to 2 flights per hours between 7:30 and 14:00 CEST. These soundings have been accompanied by flyovers of a manned ultra light aircraft of the IMK-IFU. Finally a third experiment (06.08.2015) tried to evaluate longer flights (up to 55 minutes) of two UAVs at constant levels of 300 and 500 m above ground level between 6:00 and 14:00 CEST in order to cover the early diurnal cycle even more constantly by the in situ measurements. A midnight profile for measuring the staring conditions of the development has been measured up to a hight of 1600 m, which was the permitted limit for this campaign. Data analysis using a newly developed 3D software showed that these flight experiments are able to reveal several distinct meteorological processes developing during the diurnal cycle which are shortly discussed on the poster.

10 CFR 455.64 - Life-cycle cost methodology.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life-cycle cost methodology. 455.64 Section 455.64 Energy..., Hospitals, Units of Local Government, and Public Care Institutions § 455.64 Life-cycle cost methodology. (a) The life-cycle cost methodology under § 455.63(b) of this part is a systematic comparison of the...

10 CFR 455.64 - Life-cycle cost methodology.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life-cycle cost methodology. 455.64 Section 455.64 Energy..., Hospitals, Units of Local Government, and Public Care Institutions § 455.64 Life-cycle cost methodology. (a) The life-cycle cost methodology under § 455.63(b) of this part is a systematic comparison of the...

Preliminary Design of the Brazilian's National Institute for Space Research Broadband Radiometer for Solar Observations

NASA Astrophysics Data System (ADS)

Berni, L. A.; Vieira, L. E. A.; Savonov, G. S.; Dal Lago, A.; Mendes, O.; Silva, M. R.; Guarnieri, F.; Sampaio, M.; Barbosa, M. J.; Vilas Boas, J. V.; Branco, R. H. F.; Nishimori, M.; Silva, L. A.; Carlesso, F.; Rodríguez Gómez, J. M.; Alves, L. R.; Vaz Castilho, B.; Santos, J.; Silva Paula, A.; Cardoso, F.

2017-10-01

The Total Solar Irradiance (TSI), which is the total radiation arriving at Earth's atmosphere from the Sun, is one of the most important forcing of the Earths climate. Measurements of the TSI have been made employing instruments on board several space-based platforms during the last four solar cycles. However, combining these measurements is still challenging due to the degradation of the sensor elements and the long-term stability of the electronics. Here we describe the preliminary efforts to design an absolute radiometer based on the principle of electrical substitution that is under development at Brazilian's National Institute for Space Research (INPE).

Interdisciplinary research career development: building interdisciplinary research careers in women's health program best practices.

PubMed

Domino, Steven E; Bodurtha, Joann; Nagel, Joan D

2011-11-01

The Office of Research on Women's Health (ORWH) and the National Institutes of Health (NIH) Institutes and Centers and the Agency for Health Care Research and Quality (AHRQ) have sponsored an interdisciplinary research career development program in five funding cycles since 2000 through a K12 mechanism titled "Building Interdisciplinary Research Careers in Women's Health (BIRCWH)." As of 2010, 407 scholars have been supported in interdisciplinary women's health research and a total of 63 BIRCWH program awards have been made to 41 institutions across the U.S. In an effort to share practical approaches to interdisciplinary research training, currently funded BIRCWH sites were invited to submit 300-word bullet-point style summaries describing their best practices in interdisciplinary research training following a common format with an emphasis on practices that are innovative, can be reproduced in other places, and advance women's health research. Twenty-six program narratives provide unique perspectives along with common elements and themes in interdisciplinary research training best practices.

Growing a New Culture of Assessment: Planting ePortfolios in the Metro Academies Program

ERIC Educational Resources Information Center

Shada, Alycia; Kelly, Kevin; Cox, Ruth; Malik, Savita

2011-01-01

This paper provides a look at the development of a new culture of assessment in higher education with the use of electronic portfolios (ePortfolios). It uses the metaphor of horticulture to describe how an inter-institutional program, Metro Academies of Health, has gone through the first two parts of the ePorticulture cycle--preparing for the use…

Georgetown University Integrated Community Energy System (GU-ICES). Phase III, Stage I. Feasibility analysis. Final report. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This Feasibility Analysis covers a wide range of studies and evaluations. The Report is divided into five parts. Section 1 contains all material relating to the Institutional Assessment including consideration of the requirements and position of the Potomac Electric Co. as they relate to cogeneration at Georgetown in parallel with the utility (Task 1). Sections 2 through 7 contain all technical information relating to the Alternative Subsystems Analysis (Task 4). This includes the energy demand profiles upon which the evaluations were based (Task 3). It further includes the results of the Life-Cycle-Cost Analyses (Task 5) which are developed in detailmore » in the Appendix for evaluation in the Technical Report. Also included is the material relating to Incremental Savings and Optimization (Task 6) and the Conceptual Design for candidate alternate subsystems (Task 7). Section 8 contains all material relating to the Environmental Impact Assessment (Task 2). The Appendix contains supplementary material including the budget cost estimates used in the life-cycle-cost analyses, the basic assumptions upon which the life-cycle analyses were developed, and the detailed life-cycle-cost anlysis for each subsystem considered in detail.« less

On the design of anaesthesia record forms.

PubMed

Fisher, J A; Bromberg, I L; Eisen, L B

1994-10-01

The purpose of this report is to develop a rational approach to the design of anaesthesia record forms. The history of anaesthesia record forms was reviewed. A logical approach to the design of an anaesthesia record was developed. The theoretical ideal anaesthetic record was contemplated and criteria were developed for the selection of items to be included in or excluded from the record. Principles were outlined which lead to logical organization of information on the form, improved ergonomics of data entry, and ready access to entered information. A desktop publishing system was used to execute quickly numerous form artwork revision cycles and iteratively converge on a complete design. This approach has resulted in the development and production of a new anaesthesia record for our institution. The record was well accepted by our colleagues. The rationale that has been developed is presented in the hope that it will be useful to others in the process of designing anaesthesia records for their institutions.

Developing Institutional Capacity for Reproductive Health in Humanitarian Settings: A Descriptive Study

PubMed Central

Tran, Nguyen-Toan; Dawson, Angela; Meyers, Janet; Krause, Sandra; Hickling, Carina

2015-01-01

Introduction Institutions play a central role in advancing the field of reproductive health in humanitarian settings (RHHS), yet little is known about organizational capacity to deliver RHHS and how this has developed over the past decade. This study aimed to document the current institutional experiences and capacities related to RHHS. Materials and Methods Descriptive study using an online questionnaire tool. Results Respondents represented 82 institutions from 48 countries, of which two-thirds originated from low-and middle-income countries. RHHS work was found not to be restricted to humanitarian agencies (25%), but was also embraced by development organizations (25%) and institutions with dual humanitarian and development mandates (50%). Agencies reported working with refugees (81%), internally-displaced (87%) and stateless persons (20%), in camp-based settings (78%), and in urban (83%) and rural settings (78%). Sixty-eight percent of represented institutions indicated having an RHHS-related policy, 79% an accountability mechanism including humanitarian work, and 90% formal partnerships with other institutions. Seventy-three percent reported routinely appointing RH focal points to ensure coordination of RHHS implementation. There was reported progress in RHHS-related disaster risk reduction (DRR), emergency management and coordination, delivery of the Minimum Initial Services Package (MISP) for RH, comprehensive RH services in post-crisis/recovery situations, gender mainstreaming, and community-based programming. Other reported institutional areas of work included capacity development, program delivery, advocacy/policy work, followed by research and donor activities. Except for abortion-related services, respondents cited improved efforts in advocacy, capacity development and technical support in their institutions for RHHS to address clinical services, including maternal and newborn health, sexual violence prevention and response, HIV prevention, management of sexually-transmitted infections, adolescent RH, and family planning. Approximately half of participants reported that their institutions had experienced an increase in dedicated budget and staff for RHHS, a fifth no change, and 1 in 10 a decrease. The Interagency RH Kits were reportedly the most commonly used supplies to support RHHS implementation. Conclusion The results suggest overall growth in institutional capacity in RHHS over the past decade, indicating that the field has matured and expanded from crisis response to include RHHS into DRR and other elements of the emergency management cycle. It is critical to consolidate the progress to date, address gaps, and sustain momentum. PMID:26331474

75 FR 32957 - National Human Genome Research Institute; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Human Genome... unwarranted invasion of personal privacy. Name of Committee: National Human Genome Research Institute Special... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome Research...

Assessment of ovarian cycles in the African elephant (Loxodonta africana) by measurement of salivary progesterone metabolites.

PubMed

Illera, Juan-Carlos; Silván, Gema; Cáceres, Sara; Carbonell, Maria-Dolores; Gerique, Cati; Martínez-Fernández, Leticia; Munro, Coralie; Casares, Miguel

2014-01-01

Monitoring ovarian cycles through hormonal analysis is important in order to improve breeding management of captive elephants, and non-invasive collection techniques are particularly interesting for this purpose. However, there are some practical difficulties in collecting proper samples, and easier and more practical methods may be an advantage for some institutions and/or some animals. This study describes the development and validation of an enzymeimmunoassay (EIA) for progestins in salivary samples of African elephants, Loxodonta africana. Weekly urinary and salivary samples from five non-pregnant elephant cows aged 7-12 years were obtained for 28 weeks and analyzed using EIA. Both techniques correlated positively (r = 0.799; P < 0.001), and the cycle characteristics obtained were identical. The results clearly show that ovarian cycles can be monitored by measuring progestins from salivary samples in the African elephant. This is a simple and non-invasive method that may be a practical alternative to other sampling methods used in the species. © 2014 Wiley Periodicals, Inc.

The carbon cycle revisited

NASA Technical Reports Server (NTRS)

Bolin, Bert; Fung, Inez

1992-01-01

Discussions during the Global Change Institute indicated a need to present, in some detail and as accurately as possible, our present knowledge about the carbon cycle, the uncertainties in this knowledge, and the reasons for these uncertainties. We discuss basic issues of internal consistency within the carbon cycle, and end by summarizing the key unknowns.

Protecting Ideas: Ethical and Legal Considerations When a Grant's Principal Investigator Changes.

PubMed

Koniaris, Leonidas G; Coombs, Mary I; Meslin, Eric M; Zimmers, Teresa A

2016-08-01

Ethical issues related the responsible conduct of research involve questions concerning the rights and obligations of investigators to propose, design, implement, and publish research. When a principal investigator (PI) transfers institutions during a grant cycle, financial and recognition issues need to be addressed to preserve all parties' obligations and best interests in a mutually beneficial way. Although grants often transfer with the PI, sometimes they do not. Maintaining a grant at an institution after the PI leaves does not negate the grantee institution's obligation to recognize the PI's original ideas, contributions, and potential rights to some forms of expression and compensation. Issues include maintaining a role for the PI in determining how to take credit for, share and publish results that involve his or her original ideas. Ascribing proper credit can become a thorny issue. This paper provides a framework for addressing situations and disagreements that may occur when a new PI continues the work after the original PI transfers. Included are suggestions for proactively developing institutional mechanisms that address such issues. Considerations include how to develop solutions that comply with the responsible conduct of research, equitably resolve claims regarding reporting of results, and avoid the possibility of plagiarism.

Some observations on World Development Report 2011: conflict, security and development.

PubMed

Gangolli, Leena V

2011-01-01

The World Development Report 2011 describes the relationship between conflict, security and development and makes a strong argument in favour of strengthening legitimate institutions to reduce the fragility of countries facing protracted cycles of violence, and moving from violence to resilience in order to realise development goals. While highlighting some of the lessons learned from the report (the nature of violence in the 21st century, the global reach of seemingly local conflicts, the universality of conflict as an impediment to development, the role of the international community, and the impact on health), this comment discusses the role of development on conflict and security--particularly the role of imbalanced inequitable development on fuelling conflict and insecurity.

Identifying and Assessing Interaction Knowledge, Skills, and Attributes for Future Force Soldiers

DTIC Science & Technology

2007-05-01

Research Institute for the Behavioral and Social Sciences (ARI) SBIR request, the Army Interpersonal Skills Assessment ( AISA ) battery consists of five...Army evolves over the coming years, Soldiers will be placed in positions that require increasing interaction effectiveness. The goal of the AISA is...effective interpersonal KSAs may improve performance. In Phase II of this SBIR effort, the AISA battery underwent a full development cycle

A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice.

PubMed

Angelou, Anastasios; Andreatos, Nikolaos; Antoniou, Efstathios; Zacharioudaki, Argiro; Theodoropoulos, George; Damaskos, Christos; Garmpis, Nikolaos; Yuan, Chunhui; Xiao, Weidong; Theocharis, Stamatios; Zografos, George; Papalois, Apostolos; Margonis, Georgios Antonios

2018-06-01

Our aim was to develop an animal model of the precancerous stages of colitis-associated carcinogenesis by modifying the established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol. Six mice were treated with varying cycles of DSS following AOM administration as above (group 1: three mice received three 5-day cycles of 3.0% DSS and group 2: three mice received three 7-day cycles of 2.5% DSS; every cycle was followed by a 2-week rest period) and were sacrificed on day 84 of the experiment. By contrast, three female C57BL6 mice (group 3) were treated with a single intraperitoneal dose (10 mg/kg of body weight) of AOM followed by three 5-day cycles of oral 2.5% DSS, with each cycle interrupted by a 2-week rest period. The mice of this group were sacrificed at 60 days. In groups 1 and 2, cancer was noted in five out of the six mice. In group 3, adenomas with dysplastic lesions were noted in all of the mice, but none had developed adenocarcinoma. Our results suggest that the administration of three 5-day cycles of 2.5% DSS following an initial dose of AOM may successfully induce adenoma formation without the concurrent presence of carcinoma in female C57BL6 mice that are sacrificed on experimental day 60. In turn, this modification of the widely used AOM/DSS protocol may constitute a novel approach for investigating colitis-related colonic adenomas. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

75 FR 156 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Allergy and... and funding cycle. Name of Committee: National Institute of Allergy and Infectious Diseases Special...

76 FR 59415 - National Institute on Drug Abuse; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel, Multisites... Administrator, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4234, MSC 9550... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction...

Integrating repositories with fuel cycles: The airport authority model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forsberg, C.

2012-07-01

The organization of the fuel cycle is a legacy of World War II and the cold war. Fuel cycle facilities were developed and deployed without consideration of the waste management implications. This led to the fuel cycle model of a geological repository site with a single owner, a single function (disposal), and no other facilities on site. Recent studies indicate large economic, safety, repository performance, nonproliferation, and institutional incentives to collocate and integrate all back-end facilities. Site functions could include geological disposal of spent nuclear fuel (SNF) with the option for future retrievability, disposal of other wastes, reprocessing with fuelmore » fabrication, radioisotope production, other facilities that generate significant radioactive wastes, SNF inspection (navy and commercial), and related services such as SNF safeguards equipment testing and training. This implies a site with multiple facilities with different owners sharing some facilities and using common facilities - the repository and SNF receiving. This requires a different repository site institutional structure. We propose development of repository site authorities modeled after airport authorities. Airport authorities manage airports with government-owned runways, collocated or shared public and private airline terminals, commercial and federal military facilities, aircraft maintenance bases, and related operations - all enabled and benefiting the high-value runway asset and access to it via taxi ways. With a repository site authority the high value asset is the repository. The SNF and HLW receiving and storage facilities (equivalent to the airport terminal) serve the repository, any future reprocessing plants, and others with needs for access to SNF and other wastes. Non-public special-built roadways and on-site rail lines (equivalent to taxi ways) connect facilities. Airport authorities are typically chartered by state governments and managed by commissions with members appointed by the state governor, county governments, and city governments. This structure (1) enables state and local governments to work together to maximize job and tax benefits to local communities and the state, (2) provides a mechanism to address local concerns such as airport noise, and (3) creates an institutional structure with large incentives to maximize the value of the common asset, the runway. A repository site authority would have a similar structure and be the local interface to any national waste management authority. (authors)« less

Study on the financing mechanism and management for decommissioning of nuclear installations in Malaysia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saleh, Lydia Ilaiza, E-mail: lydiailaiza@gmail.com; Ryong, Kim Tae

The whole cycle of the decommissioning process development of repository requires the relevant bodies to have a financial system to ensure that it has sufficient funds for its whole life cycle (over periods of many decades). Therefore, the financing mechanism and management system shall respect the following status: the national position, institutional and legislative environment, technical capabilities, the waste origin, ownership, characteristics and inventories. The main objective of the studies is to focus on the cost considerations, alternative funding managements and mechanisms, technical and non-technical factors that may affect the repository life-cycle costs. As a conclusion, the outcomes of thismore » paper is to make a good recommendation and could be applied to the national planners, regulatory body, engineers, or the managers, to form a financial management plan for the decommissioning of the Nuclear Installation.« less

Proposal Auto-Categorizer and Manager for Time Allocation Review at Space Telescope Science Institute

NASA Astrophysics Data System (ADS)

Porter, Sophia; Strolger, Louis-Gregory; Lagerstrom, Jill; Weissman, Sarah

2016-01-01

The Space Telescope Science Institute annually receives more than one thousand formal proposals for Hubble Space Telescope time, exceeding the available time with the observatory by a factor of over four. With JWST, the proposal pressure will only increase, straining our ability to provide rigorous peer review of each proposal's scientific merit. Significant hurdles in this process include the proper categorization of proposals, to ensure Time Allocation Committees (TACs) have the required and desired expertise to fairly and appropriately judge each proposal, and the selection of reviewers themselves, to establish diverse and well-qualified TACs. The Panel Auto-Categorizer and Manager (PACMan; a naive Bayesian classifier) was developed to automatically sort new proposals into their appropriate science categories and, similarly, to appoint panel reviewers with the best qualifications to serve on the corresponding TACs. We will provide an overview of PACMan and present the results of its testing on five previous cycles of proposals. PACMan will be implemented in upcoming cycles to support and eventually replace the process for constructing the time allocation reviews.

Survey of alternative gas turbine engine and cycle design. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lukas, H.

1986-02-01

In the period of the 1940's to 1960's much experimentation was performed in the areas of intercooling, reheat, and recuperation, as well as the use of low-grade fuels in gas turbines. The Electric Power Research Institute (EPRI), in an effort to document past experience which can be used as the basis for current design activities, commissioned a study to document alternate cycles and components used in gas turbine design. The study was performed by obtaining the important technical and operational criteria of the cycles through a literature search of published documents, articles, and papers. Where possible the information was augmentedmore » through dialogue with persons associated with those cycles and with the manufacturers. The survey indicated that many different variations of the simple open-cycle gas turbine plant were used. Many of these changes resulted in increases in efficiency over the low simple-cycle efficiency of that period. Metallurgy, as well as compressor and turbine design, limited the simple-cycle efficiency to the upper teens. The cycle modifications increased those efficiencies to the twenties and thirties. Advances in metallurgy as well as compressor and turbine design, coupled with the decrease in flue cost, stopped the development of these complex cycles. Many of the plants operated successfully for many years, and only because newer simple-cycle gas turbine plants and large steam plants had better heat rates were these units shutdown or put into stand-by service. 24 refs., 25 figs., 114 tabs.« less

Influences On The Oceanic Biogeochemical Cycling Of The Hybrid-Type Metals: Cobalt, Iron, And Manganese

DTIC Science & Technology

2012-02-01

have been possible. We also thank Scot Birdwhistell in the Woods Hole Oceanographic Institution (WHOI) inductively coupled plasma mass spectrometry...Cobalt, Iron, and Manganese MIT/WHOI Joint Program in Oceanography/ Applied Ocean Science and Engineering Massachusetts Institute of Technology Woods Hole...by Abigail Emery Noble Massachusetts Institute of Technology Cambridge, Massachusetts 02139 and Woods Hole Oceanographic Institution Woods Hole

OSPREY Model Development Status Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veronica J Rutledge

2014-04-01

During the processing of used nuclear fuel, volatile radionuclides will be discharged to the atmosphere if no recovery processes are in place to limit their release. The volatile radionuclides of concern are 3H, 14C, 85Kr, and 129I. Methods are being developed, via adsorption and absorption unit operations, to capture these radionuclides. It is necessary to model these unit operations to aid in the evaluation of technologies and in the future development of an advanced used nuclear fuel processing plant. A collaboration between Fuel Cycle Research and Development Offgas Sigma Team member INL and a NEUP grant including ORNL, Syracuse University,more » and Georgia Institute of Technology has been formed to develop off gas models and support off gas research. Georgia Institute of Technology is developing fundamental level model to describe the equilibrium and kinetics of the adsorption process, which are to be integrated with OSPREY. This report discusses the progress made on expanding OSPREY to be multiple component and the integration of macroscale and microscale level models. Also included in this report is a brief OSPREY user guide.« less

Institutional Audits: A Comparison of the Experiences of Three South African Universities

ERIC Educational Resources Information Center

Botha, Jan; Favish, Judy; Stephenson, Sandra

2008-01-01

South Africa's external quality assurance agency, the Higher Education Quality Committee (HEQC), commenced its first cycle of institutional audits in 2004. During 2005, three public higher education institutions were audited, namely the University of Cape Town, the University of Stellenbosch and Rhodes University. The process of preparing for and…

78 FR 63996 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Allergy and Infectious Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the Federal... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Allergy and... limitations imposed by the review and funding cycle. Name of Committee: National Institute of Allergy and...

Defense ADP Acquisition Study.

DTIC Science & Technology

1981-11-30

Logistics ALS - Advanced Logistics System AMP - ADPS Master Plan ANSI - American National Standards Institute APR - Agency Procurement Request ASD(C...Computers IRM - Information Resources Management ISO - International Standards Organization L LCC - Life Cycle Costs LCM - Life Cycle Management LE...man- agement in the process * Lack of a mission orientation . Lack of systems management and life cycle perspectives * Lack of effective leadership

SERIIUS-MAGEEP Visiting Scholars Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ortega, Jesus D.

2014-08-28

Recent studies have assessed closed-loop supercritical carbon dioxide (s-CO 2) Brayton cycles to be a higher energy-density system in comparison to equivalent superheated steam Rankine systems. At turbine inlet conditions of 700°C and 20 MPa, a cycle thermal efficiency of ~50% can be achieved. Achieving these high efficiencies will help concentrating solar power (CSP) technologies to become a competitive alternative to current power generation methods. To incorporate an s-CO 2 Brayton power cycle in a solar power tower system, the development of a solar receiver capable of providing an outlet temperature of 700°C (at 20 MPa) is necessary. To satisfymore » the temperature requirements of an s-CO 2 Brayton cycle with recuperation and recompression, the s-CO 2 must undergo a temperature rise of ~200°C as it flows through the solar receiver. The main objective is to develop an optical-thermal-fluid and structural model to validate a tubular receiver that will receive a heat input ~0.33 MWth from the heliostat field at the National Solar Thermal Test Facility (NSTTF), Albuquerque, NM, USA. We also commenced the development of computational models and testing of air receivers being developed by the Indian Institute of Science (IISc) and the Indian Institute of Technology in Bombay (IIT-B). The helical tubular receiver is expected to counteract the effect of thermal expansion while using a cavity to reduce the radiative and convective losses. Initially, this receiver will be tested for a temperature range of 100-300°C under 1 MPa of pressurized air. The helical air receiver will be exposed to 10kWth to achieve a temperature rise of ~200°C. Preliminary tests to validate the modeling will be performed before the design and construction of a larger scale receiver. Lastly, I focused on the development of a new computational tool that would allow us to perform a nodal creep-fatigue analysis on the receivers and heat exchangers being developed. This tool was developed using MATLAB and is capable of processing the results obtained from ANSYS Fluent and Structural combined, which was limited when using commercial software. The main advantage of this code is that it can be modified to run in parallel making it more affordable and faster compared to commercial codes available. The code is in the process of validation and is currently being compared to nCode Design Life.« less

Third cycle university studies in Europe in the field of agricultural engineering and in the emerging discipline of biosystems engineering.

PubMed

Ayuga, F; Briassoulis, D; Aguado, P; Farkas, I; Griepentrog, H; Lorencowicz, E

2010-01-01

The main objectives of European Thematic Network entitled 'Education and Research in Agricultural for Biosystems Engineering in Europe (ERABEE-TN)' is to initiate and contribute to the structural development and the assurance of the quality assessment of the emerging discipline of Biosystems Engineering in Europe. ERABEE is co-financed by the European Community in the framework of the LLP Programme. The partnership consists of 35 participants from 27 Erasmus countries, out of which 33 are Higher Education Area Institutions (EDU) and 2 are Student Associations (ASS). 13 Erasmus participants (e.g. Thematic Networks, Professional Associations, and Institutions from Brazil, Croatia, Russia and Serbia) are also involved in the Thematic Network through synergies. To date, very few Biosystems Engineering programs exist in Europe and those that are initiated are at a very primitive stage of development. The innovative and novel goal of the Thematic Network is to promote this critical transition, which requires major restructuring in Europe, exploiting along this direction the outcomes accomplished by its predecessor; the USAEE-TN (University Studies in Agricultural Engineering in Europe). It also aims at enhancing the compatibility among the new programmes of Biosystems Engineering, aiding their recognition and accreditation at European and International level and facilitating greater mobility of skilled personnel, researchers and students. One of the technical objectives of ERABEE is dealing with mapping and promoting the third cycle studies (including European PhDs) and supporting the integration of research at the 1st and 2nd cycle regarding European Biosystems Engineering university studies. During the winter 2008 - spring 2009 period, members of ERABEE conducted a survey on the contemporary status of doctoral studies in Europe, and on a possible scheme for promotion of cooperation and synergies in the framework of the third cycle of studies and the European Doctorate in Biosystems Engineering in Europe. This paper presents the results of the survey. The legal regulations and their extent on the different countries concerning the third cycle are presented, along with the current structure of third cycle studies. The evolution and adaptation to the new EHEA in each country is also considered. Information was also gathered on the emerging topics of the Biosystems Engineering field and how these topics could be addressed by the new doctoral programmes at the European level.

Interdisciplinary Research Career Development: Building Interdisciplinary Research Careers in Women's Health Program Best Practices

PubMed Central

Bodurtha, Joann; Nagel, Joan D.

2011-01-01

Abstract Background The Office of Research on Women's Health (ORWH) and the National Institutes of Health (NIH) Institutes and Centers and the Agency for Health Care Research and Quality (AHRQ) have sponsored an interdisciplinary research career development program in five funding cycles since 2000 through a K12 mechanism titled “Building Interdisciplinary Research Careers in Women's Health (BIRCWH).” As of 2010, 407 scholars have been supported in interdisciplinary women's health research and a total of 63 BIRCWH program awards have been made to 41 institutions across the U.S. Methods In an effort to share practical approaches to interdisciplinary research training, currently funded BIRCWH sites were invited to submit 300-word bullet-point style summaries describing their best practices in interdisciplinary research training following a common format with an emphasis on practices that are innovative, can be reproduced in other places, and advance women's health research. Results and Conclusions Twenty-six program narratives provide unique perspectives along with common elements and themes in interdisciplinary research training best practices. PMID:21923414

Climate-Energy Nexus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sayler, Gary; Gentry, Randall; Zhuang, Jie

2010-07-01

The 140-page published proceedings of the workshop include individual articles and PowerPoint slides for all workshop presentations. The proceedings also contain pertinent background information on the China-US Joint Research Center, partnering organizations, and workshop goals and objectives. Overall, the workshop increased the understanding of the impacts of climate change on energy use and renewable energy production as well as the complex relationships among land use, energy production, and ecological restoration. The workshop served as an international platform for scientists and students of different research backgrounds to develop a unified perspective on energy and climate relationships. Such understanding will benefit futuremore » cooperation between China and the US in mitigating global climate change. The workshop’s agenda, which is highly interdisciplinary, explored many potential opportunities for international collaboration in ecosystem management, climate modeling, greenhouse gas emissions, and bioenergy sustainability. International research groups have been suggested in the areas of genomes and biotechnology of energy plants, sustainable management of soil and water resources, carbon sequestration, and microbial processes for ecological cycles. The project has attracted considerable attention from institutes beyond the China-US Joint Research Center partners, and several of them (such as Institute of Qing-Tibet Plateau Research, Institute of Soil and Water Conservation, Institute of Applied Ecology, CAS) have expressed interest in joining the partnership. In addition, the workshop played a significant role in facilitating establishment of private-public partnerships between government and private bioenergy companies (such as L.R. Shugarts and Associates, Inc.), including seed providers (Blade Energy Crops, Thousand Oaks, CA), pilot demonstration projects at coal-producing cities (e.g., Huaibei, Anhui province, China), and the development of methodology for assessment of the sustainable production of biofuels (such as life-cycle analysis, sustainability metrics, and land-use policy). Establishment of two US-China scientific research networks in the area of bioenergy and environmental science is a significant result of the workshop.« less

Institutional arrangements for the reduction of proliferation risks formulation, evaluation, and implementation of institutional concepts. Appendices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The purpose of this supporting analysis is to provide a foundation for developing a model, an international or multinational institution capable of accomodating the back end of the fuel cycle, while meeting US nonproliferation goals. The analysis is based on a review of selected, defunct and extant institutions which, although not necessarily concerned with nonproliferation, have faced a trade-off between acceptability and effectiveness in meeting their objectives. Discussion of the various institutions is divided into three categories: international organizations, multinational consortia, and cartels or producer associations. Examples of international organizations include the International Seabed Authority, Intelsat, the United Nations andmore » the International Atomic Energy Agency (IAEA). The International Seabed Authority is discussed. Multinational consortia are organizations that have been developed primarily to meet common commercial objectives. Membership includes at least three member nations. Examples include the Scandinavian Airline System (SAS), URENCO, Unilever, Royal Dutch Shell, Eurochemic, Eurodif, Euratom, European Coal and Steel Community, and Serena. Cartels or producer associations are multinational agreements that restrict market forces; viz, production, market share, customers or prices. Examples include the Intergovernmental Council of Copper Exporting Countries (CIPEC), the Organization of Petroleum Exporting Countries (OPEC), and the Fifth International Tin Agreement (ITA), as well as agreements governing diamonds and uranium, bauxite and coffee. OPEC, CIPEC and ITA are discussed.« less

Plan-Do-Check-Act and the Management of Institutional Research. AIR 1992 Annual Forum Paper.

ERIC Educational Resources Information Center

McLaughlin, Gerald W.; Snyder, Julie K.

This paper describes the application of a Total Quality Management strategy called Plan-Do-Check-Act (PDCA) to the projects and activities of an institutional research office at the Virginia Polytechnic Institute and State University. PDCA is a cycle designed to facilitate incremental continual improvement through change. The specific steps are…

National Study of Postsecondary Faculty (NSOPF-93), 1993: User's Manual--Public-Use Faculty and Institution Data.

ERIC Educational Resources Information Center

Selfa, Lance A.; Suter, Natalie; Koch, Shaun; Zahs, Daniel A.; Kuhr, Brian D.; Myers, Sharon; Johnson, Robert A.; Abraham, Sameer Y.; Zimbler, Linda J.

The 1992-93 National Study of Postsecondary Faculty (NSOPF-93), the second cycle of this study, surveyed institutions and faculty, with a sample of 974 public and private nonproprietary higher education institutions and 31,354 faculty members. The study was designed to provide a national profile of faculty, including their professional…

DMPTool: New Guidance, Resources, and Outreach for Quality Data Management Plans

NASA Astrophysics Data System (ADS)

Cruse, P.; Sallans, A.

2013-12-01

A growing number of US federal funding agencies require data management plans (DMP) as part of new research grant proposals. To help researchers with this requirement, several organizations (the California Digital Library, University of Illinois, University of Virginia, Smithsonian Institution, the DataONE consortium and the (UK) Digital Curation Centre) came together to develop the DMPTool in 2011. The goal of the DMPTool is to provide researchers with guidance, links to resources and help with writing data management plans. Thanks to a grant from the Alfred P. Sloan Foundation, these organizations have been able to develop DMPTool2, adding new features and functionality, while aiming to grow the number of users and funding requirements and build a community around DMP best practices. Researchers create plans in the tool by selecting their desired funding agency. The tool provides specific requirements from the selected agency as well as detailed help with each area of the plan. Users have access to complete DMP life cycle management, tracking changes through creation, editing, submission, evaluation, and publication. They may also perform enhanced keyword searches and view publicly available plans. With role-based user authorization, users may hold various roles within the interface: creators, collaborators, institutional administrators, and tool administrators. Furthermore, partner institutions can add significant value to the process with several special tool features. Along with institutional branding in the interface, they can provide links to resources they provide to users, such as to preservation repositories, consultation services, or news and event items. In addition, partner institutions can provide help with specific plan questions, and even suggest responses. Institutional administrators can also mine data on plans in order to better support researchers. Institutions may be represented in different roles: as a funder, a researcher's affiliate, or as an institution with its own DMP requirements.

Photorespiration participates in the assimilation of acetate in Chlorella sorokiniana under high light.

PubMed

Xie, Xiujun; Huang, Aiyou; Gu, Wenhui; Zang, Zhengrong; Pan, Guanghua; Gao, Shan; He, Linwen; Zhang, Baoyu; Niu, Jianfeng; Lin, Apeng; Wang, Guangce

2016-02-01

The development of microalgae on an industrial scale largely depends on the economic feasibility of mass production. High light induces productive suspensions during cultivation in a tubular photobioreactor. Herein, we report that high light, which inhibited the growth of Chlorella sorokiniana under autotrophic conditions, enhanced the growth of this alga in the presence of acetate. We compared pigments, proteomics and the metabolic flux ratio in C. sorokiniana cultivated under high light (HL) and under low light (LL) in the presence of acetate. Our results showed that high light induced the synthesis of xanthophyll and suppressed the synthesis of chlorophylls. Acetate in the medium was exhausted much more rapidly in HL than in LL. The data obtained from LC-MS/MS indicated that high light enhanced photorespiration, the Calvin cycle and the glyoxylate cycle of mixotrophic C. sorokiniana. The results of metabolic flux ratio analysis showed that the majority of the assimilated carbon derived from supplemented acetate, and photorespiratory glyoxylate could enter the glyoxylate cycle. Based on these data, we conclude that photorespiration provides glyoxylate to speed up the glyoxylate cycle, and releases acetate-derived CO2 for the Calvin cycle. Thus, photorespiration connects the glyoxylate cycle and the Calvin cycle, and participates in the assimilation of supplemented acetate in C. sorokiniana under high light. © 2015 Institute of Oceanography, Chinese Academy of Sciences (IOCAS). New Phytologist © 2015 New Phytologist Trust.

GEOSS Water Cycle Integrator

NASA Astrophysics Data System (ADS)

Koike, T.; Lawford, R. G.; Cripe, D.

2012-12-01

It is critically important to recognize and co-manage the fundamental linkages across the water-dependent domains; land use, including deforestation; ecosystem services; and food-, energy- and health-securities. Sharing coordinated, comprehensive and sustained observations and information for sound decision-making is a first step; however, to take full advantage of these opportunities, we need to develop an effective collaboration mechanism for working together across different disciplines, sectors and agencies, and thereby gain a holistic view of the continuity between environmentally sustainable development, climate change adaptation and enhanced resilience. To promote effective multi-sectoral, interdisciplinary collaboration based on coordinated and integrated efforts, the Global Earth Observation System of Systems (GEOSS) is now developing a "GEOSS Water Cycle Integrator (WCI)", which integrates "Earth observations", "modeling", "data and information", "management systems" and "education systems". GEOSS/WCI sets up "work benches" by which partners can share data, information and applications in an interoperable way, exchange knowledge and experiences, deepen mutual understanding and work together effectively to ultimately respond to issues of both mitigation and adaptation. (A work bench is a virtual geographical or phenomenological space where experts and managers collaborate to use information to address a problem within that space). GEOSS/WCI enhances the coordination of efforts to strengthen individual, institutional and infrastructure capacities, especially for effective interdisciplinary coordination and integration. GEO has established the GEOSS Asian Water Cycle Initiative (AWCI) and GEOSS African Water Cycle Coordination Initiative (AfWCCI). Through regional, inter-disciplinary, multi-sectoral integration and inter-agency coordination in Asia and Africa, GEOSS/WCI is now leading to effective actions and public awareness in support of water security and sustainable development.

Recovery of functionally-active protein from inclusion bodies using a thermal-cycling method.

PubMed

Sadavarte, Rahul; Filipe, Carlos D M; Ghosh, Raja

2017-01-01

Heterologous overexpression of genes in Escherichia coli has made it possible to obtain high titers of recombinant proteins. However, this can result in the formation of aggregated protein particles known as 'inclusion bodies'. Protein sequestered as inclusion body is inactive and needs to be converted back to its functional form by refolding using appropriate techniques. In the current study inclusion bodies of the enzyme aminoglycoside nucleotidyl transferase (or ANT(2″)-Ia) were first solubilized in urea and subsequently subjected to thermal cycling under controlled conditions as part of the refolding strategy. Thermal cycling led to disaggregation of the individual protein chains and simultaneously refolding the released protein molecules to their native state. The optimum condition was identified as 10-80°C thermal cycling at 3°C s -1 for 2 h. Enzyme activity measurements showed that thermal cycling under optimized conditions resulted in 257% activity recovery when compared with nonrefolded protein. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:133-139, 2017. © 2016 American Institute of Chemical Engineers.

Collaborative Project: Improving the Representation of Coastal and Estuarine Processes in Earth System Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryan, Frank; Dennis, John; MacCready, Parker

This project aimed to improve long term global climate simulations by resolving and enhancing the representation of the processes involved in the cycling of freshwater through estuaries and coastal regions. This was a collaborative multi-institution project consisting of physical oceanographers, climate model developers, and computational scientists. It specifically targeted the DOE objectives of advancing simulation and predictive capability of climate models through improvements in resolution and physical process representation.

Final Report Collaborative Project: Improving the Representation of Coastal and Estuarine Processes in Earth System Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryan, Frank; Dennis, John; MacCready, Parker

This project aimed to improve long term global climate simulations by resolving and enhancing the representation of the processes involved in the cycling of freshwater through estuaries and coastal regions. This was a collaborative multi-institution project consisting of physical oceanographers, climate model developers, and computational scientists. It specifically targeted the DOE objectives of advancing simulation and predictive capability of climate models through improvements in resolution and physical process representation.

APT, The Phase I Tool for HST Cycle 12

NASA Astrophysics Data System (ADS)

Blacker, B.; Berch, M.; Curtis, G.; Douglas, R.; Downes, R.; Krueger, A.; O'Dea, C.

2002-12-01

In our continuing effort to streamline our systems and improve service to the science community, the Space Telescope Science Institute (STScI) is developing and releasing, APT - The Astronomer's Proposal Tool as the new interface for Hubble Space Telescope (HST) Phase I and Phase II proposal submissions for HST Cycle 12. The goal of the APT, is to bring state of the art technology, more visual tools and power into the hands of proposers so that they can optimize the scientific return of their HST programs. Proposing for HST and other missions, consists of requesting observing time and/or archival research funding. This step is called Phase I, where the scientific merit of a proposal is considered by a community based peer-review process. Accepted proposals then proceed thru Phase II, where the observations are specified in sufficient detail to enable scheduling on the telescope. In this paper we will present our concept and implementation plans for our Phase I development and submission tool, APT. In addition, we will go behind the scenes and discuss the implications for the Science Policies Division (SPD) and other groups at the STScI caused by a new submission tool and submission output products. The Space Telescope Science Institute (STScI) is operated by the Association of Universities for Research in Astronomy, Inc., for the National Aeronautics and Space Administration.

Analysis of fuel cycle strategies and U.S. transition scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wigeland, Roald; Taiwo, Temitope A.

2016-10-17

The nuclear fuel cycle Evaluation and Screening (E&S) study that was completed in October 2014 [1] enabled the identification of four fuel cycle groups that are considered most promising based on a set of nine evaluation criteria: (a) six benefit criteria of Nuclear Waste Management, Proliferation Risk, Nuclear Material Security Risk, Safety, Environmental Impact, Resource Utilization, and (b) three challenge criteria of Development and Deployment Risk, Institutional Issues, Financial Risk and Economics. The E&S study was conducted at a level of analysis that is "technology- neutral," that is, without consideration of specific technologies, but using the fundamental physics characteristics ofmore » each part of the fuel cycle. The study focused on the fuel cycle performance benefits at the fuel cycle equilibrium state, with only limited consideration of transition and deployment impacts. Common characteristics of the four most promising fuel cycle options include continuous recycle of all U/Pu or U/TRU, the use of fast-spectrum reactors, and no use of uranium enrichment once fuel cycle equilibrium has been established. The high-level wastes are mainly from processing of irradiated fuel, and there would be no disposal of any spent fuel. Building on the findings of the E&S study, additional studies have been conducted in the last two years following the information exchange meeting, the 13th IEMPT, which was held in Seoul, the Republic of Korea in 2014. Insights are presented from the recent studies on the benefits and challenges of recycling minor actinides, and transition considerations to some of the most promising fuel cycle options.« less

Practices influenced by policy? An exploration of newly hired science teachers at sites in South Africa and the United States

NASA Astrophysics Data System (ADS)

Navy, S. L.; Luft, J. A.; Toerien, R.; Hewson, P. W.

2018-05-01

In many parts of the world, newly hired science teachers' practices are developing in a complex policy environment. However, little is known about how newly hired science teachers' practices are enacted throughout a cycle of instruction and how these practices can be influenced by macro-, meso-, and micro-policies. Knowing how policies impact practice can result in better policies or better support for certain policies in order to enhance the instruction of newly hired teachers. This comparative study investigated how 12 newly hired science teachers at sites in South Africa (SA) and the United States (US) progressed through an instructional cycle of planning, teaching, and reflection. The qualitative data were analysed through beginning teacher competency frameworks, the cycle of instruction, and institutional theory. Data analysis revealed prevailing areas of practice and connections to levels of policy within the instructional cycle phases. There were some differences between the SA and US teachers and among first-, second-, and third-year teachers. More importantly, this study indicates that newly hired teachers are susceptible to micro-policies and are progressively developing their practice. It also shows the importance of meso-level connectors. It suggests that teacher educators and policy makers must consider how to prepare and support newly hired science teachers to achieve the shared global visions of science teaching.

The Uphill Climb

ERIC Educational Resources Information Center

Stewart, Pearl

2012-01-01

Despite decades of research and recommendations, a revolving door continues to cycle Black and Hispanic faculty into and out of predominantly White higher education institutions. Interviews with the scholars and researchers who have examined this issue in recent years suggest that, although some institutions have ramped up their recruitment and…

76 FR 43347 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group on Diesel Aftertreatment Accelerated Aging Cycles--Heavy... Institute-- Cooperative Research Group on Diesel Aftertreatment Accelerated Aging Cycles--Heavy-Duty...

Legal, institutional, and political issues in transportation of nuclear materials at the back end of the LWR nuclear fuel cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lippek, H.E.; Schuller, C.R.

1979-03-01

A study was conducted to identify major legal and institutional problems and issues in the transportation of spent fuel and associated processing wastes at the back end of the LWR nuclear fuel cycle. (Most of the discussion centers on the transportation of spent fuel, since this activity will involve virtually all of the legal and institutional problems likely to be encountered in moving waste materials, as well.) Actions or approaches that might be pursued to resolve the problems identified in the analysis are suggested. Two scenarios for the industrial-scale transportation of spent fuel and radioactive wastes, taken together, high-light mostmore » of the major problems and issues of a legal and institutional nature that are likely to arise: (1) utilizing the Allied General Nuclear Services (AGNS) facility at Barnwell, SC, as a temporary storage facility for spent fuel; and (2) utilizing AGNS for full-scale commercial reprocessing of spent LWR fuel.« less

The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adaptive Designs Accelerating Promising Treatments Into Trials Project.

PubMed

Guetterman, Timothy C; Fetters, Michael D; Mawocha, Samkeliso; Legocki, Laurie J; Barsan, William G; Lewis, Roger J; Berry, Donald A; Meurer, William J

2017-01-01

Clinical trials are complicated, expensive, time-consuming, and frequently do not lead to discoveries that improve the health of patients with disease. Adaptive clinical trials have emerged as a methodology to provide more flexibility in design elements to better answer scientific questions regarding whether new treatments are efficacious. Limited observational data exist that describe the complex process of designing adaptive clinical trials. To address these issues, the Adaptive Designs Accelerating Promising Treatments Into Trials project developed six, tailored, flexible, adaptive, phase-III clinical trials for neurological emergencies, and investigators prospectively monitored and observed the processes. The objective of this work is to describe the adaptive design development process, the final design, and the current status of the adaptive trial designs that were developed. To observe and reflect upon the trial development process, we employed a rich, mixed methods evaluation that combined quantitative data from visual analog scale to assess attitudes about adaptive trials, along with in-depth qualitative data about the development process gathered from observations. The Adaptive Designs Accelerating Promising Treatments Into Trials team developed six adaptive clinical trial designs. Across the six designs, 53 attitude surveys were completed at baseline and after the trial planning process completed. Compared to baseline, the participants believed significantly more strongly that the adaptive designs would be accepted by National Institutes of Health review panels and non-researcher clinicians. In addition, after the trial planning process, the participants more strongly believed that the adaptive design would meet the scientific and medical goals of the studies. Introducing the adaptive design at early conceptualization proved critical to successful adoption and implementation of that trial. Involving key stakeholders from several scientific domains early in the process appears to be associated with improved attitudes towards adaptive designs over the life cycle of clinical trial development.

Bursaries and Student Success: A Study of Students from Low-Income Groups at Two Institutions in the South West

ERIC Educational Resources Information Center

Hatt, Sue; Hannan, Andrew; Baxter, Arthur

2005-01-01

This article draws on quantitative and qualitative data from two institutions to compare the student experience of those with and without bursary awards. Using the student life cycle model, the article examines the ways in which bursaries impact on the student experience before they enter the institution, in the early weeks of their studies and as…

From the field to classrooms: Scientists and educators collaborating to develop K-12 lessons on arctic carbon cycling and climate change that align with Next Generation Science Standards, and informal outreach programs that bring authentic data to informal audiences.

NASA Astrophysics Data System (ADS)

Brinker, R.; Cory, R. M.

2014-12-01

Next Generation Science Standards (NGSS) calls for students across grade levels to understand climate change and its impacts. To achieve this goal, the NSF-sponsored PolarTREC program paired an educator with scientists studying carbon cycling in the Arctic. The data collection and fieldwork performed by the team will form the basis of hands-on science learning in the classroom and will be incorporated into informal outreach sessions in the community. Over a 16-day period, the educator was stationed at Toolik Field Station in the High Arctic. (Toolik is run by the University of Alaska, Fairbanks, Institute of Arctic Biology.) She participated in a project that analyzed the effects of sunlight and microbial content on carbon production in Artic watersheds. Data collected will be used to introduce the following NGSS standards into the middle-school science curriculum: 1) Construct a scientific explanation based on evidence. 2) Develop a model to explain cycling of water. 3) Develop and use a model to describe phenomena. 4) Analyze and interpret data. 5) A change in one system causes and effect in other systems. Lessons can be telescoped to meet the needs of classrooms in higher or lower grades. Through these activities, students will learn strategies to model an aspect of carbon cycling, interpret authentic scientific data collected in the field, and conduct geoscience research on carbon cycling. Community outreach sessions are also an effective method to introduce and discuss the importance of geoscience education. Informal discussions of firsthand experience gained during fieldwork can help communicate to a lay audience the biological, physical, and chemical aspects of the arctic carbon cycle and the impacts of climate change on these features. Outreach methods will also include novel use of online tools to directly connect audiences with scientists in an effective and time-efficient manner.

Collaboration between practice, policy and research in local public health in the Netherlands.

PubMed

Jansen, Maria W J; De Vries, Nanne K; Kok, Gerjo; Van Oers, Hans A M

2008-05-01

The collaboration between policy, practice, and research in local public health was studied in a multiple case study. The assumption is that collaboration will result in more solid evidence and higher quality standards in public health. First, collaboration barriers were studied by analysing the work cycles of the three domains, which are considered to operate as niches. Actors at the administrative, institutional, and individual levels were identified. Theories that describe processes of the convergence of the three niches through practical strategies were sought. Finally, the application of the practical strategies in six cases was evaluated. When administrative, institutional, and individual changes develop in a similar fashion and in parallel with each other, the likelihood of successful collaboration that goes beyond the initial period is greater. The findings suggest that organisational development (OD) strategies that address collaboration at the institutional level make a relatively strong contribution. Top level consultations just after local elections, investments in OD strategies and a new kind of accountability in public health are recommended. The assumption that successful collaboration contributes to enhanced effectiveness, efficiency, and efficacy of public health could not yet be unequivocally confirmed.

JGI's Carbon Cycling Studies on Restored Marshes

ScienceCinema

Tringe, Susannah; Theroux, Susanna

2018-02-14

DOE Joint Genome Institute Metagenome Program Head, Susannah Tringe, and postdoc, Susie Theroux, discuss the lessons to be learned from studying the microbial diversity of marshes that have been converted to other uses, and are now being restored, as well as the potential impacts on the global carbon cycle.

PERFORMANCE OF A TWO-CYCLE REFRIGERATOR/FREEZER USING HFC REFRIGERANTS

EPA Science Inventory

A two-cycle 18 ft3 (0.51 m3) refrigerator/freezer (R/F) was tested utilizing American National Standards Institute (ANSI)/AHAM (1988) standards for energy consumption testing. A 34.9% energy consumption reduction was realized. This work presents a proven method of reducing the ...

75 FR 14191 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... DEPARTMENT OF JUSTICE Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Cooperative Research Group On: Diesel After Treatment Accelerated Aging Cycles--Heavy... Institute--Cooperative Research Group on Diesel After Treatment Accelerated Aging Cycles--Heavy-Duty...

Impact of Accreditation on Public and Private Universities: A Comparative Study

ERIC Educational Resources Information Center

Dattey, Kwame; Westerheijden, Don F.; Hofman, Wiecher H. Adriaan

2014-01-01

Based on two cycles of assessments for accreditation, this study assesses the differential impacts of accreditation on public and private universities in Ghana. Analysis of the evaluator reports indicates no statistically significant difference--improvement or deterioration--between the two cycles of evaluations for both types of institutions. A…

GEOSS Water Cycle Integrator

NASA Astrophysics Data System (ADS)

Koike, Toshio; Lawford, Richard; Cripe, Douglas

2013-04-01

It is critically important to recognize and co-manage the fundamental linkages across the water-dependent domains; land use, including deforestation; ecosystem services; and food-, energy- and health-securities. Sharing coordinated, comprehensive and sustained observations and information for sound decision-making is a first step; however, to take full advantage of these opportunities, we need to develop an effective collaboration mechanism for working together across different disciplines, sectors and agencies, and thereby gain a holistic view of the continuity between environmentally sustainable development, climate change adaptation and enhanced resilience. To promote effective multi-sectoral, interdisciplinary collaboration based on coordinated and integrated efforts, the intergovernmental Group on Earth Observations (GEO) is implementing the Global Earth Observation System of Systems (GEOSS). A component of GEOSS now under development is the "GEOSS Water Cycle Integrator (WCI)", which integrates Earth observations, modeling, data and information, management systems and education systems. GEOSS/WCI sets up "work benches" by which partners can share data, information and applications in an interoperable way, exchange knowledge and experiences, deepen mutual understanding and work together effectively to ultimately respond to issues of both mitigation and adaptation. (A work bench is a virtual geographical or phenomenological space where experts and managers collaborate to use information to address a problem within that space). GEOSS/WCI enhances the coordination of efforts to strengthen individual, institutional and infrastructure capacities, especially for effective interdisciplinary coordination and integration. GEO has established the GEOSS Asian Water Cycle Initiative (AWCI) and GEOSS African Water Cycle Coordination Initiative (AfWCCI). Through regional, inter-disciplinary, multi-sectoral integration and inter-agency coordination in Asia and Africa, GEOSS/WCI is now leading to effective actions and public awareness in support of water security and sustainable development.

Extraction of human gait signatures: an inverse kinematic approach using Groebner basis theory applied to gait cycle analysis

NASA Astrophysics Data System (ADS)

Barki, Anum; Kendricks, Kimberly; Tuttle, Ronald F.; Bunker, David J.; Borel, Christoph C.

2013-05-01

This research highlights the results obtained from applying the method of inverse kinematics, using Groebner basis theory, to the human gait cycle to extract and identify lower extremity gait signatures. The increased threat from suicide bombers and the force protection issues of today have motivated a team at Air Force Institute of Technology (AFIT) to research pattern recognition in the human gait cycle. The purpose of this research is to identify gait signatures of human subjects and distinguish between subjects carrying a load to those subjects without a load. These signatures were investigated via a model of the lower extremities based on motion capture observations, in particular, foot placement and the joint angles for subjects affected by carrying extra load on the body. The human gait cycle was captured and analyzed using a developed toolkit consisting of an inverse kinematic motion model of the lower extremity and a graphical user interface. Hip, knee, and ankle angles were analyzed to identify gait angle variance and range of motion. Female subjects exhibited the most knee angle variance and produced a proportional correlation between knee flexion and load carriage.

Value Criteria for School Furniture

ERIC Educational Resources Information Center

Spellman, Walter

2012-01-01

Making furniture decisions can involve many factors, and they vary from institution to institution. For fixtures, furnishings and equipment, comparing initial cost with the cost of ownership over a life cycle can be more challenging. It may be the functionality of the furnishings that provides the greatest return on investment. In this article,…

Autonomy versus Affirmative Action: What Price Social Justice?

ERIC Educational Resources Information Center

Cavalier, Anne; Slaughter, Sheila

1982-01-01

A study measured costs of an affirmative action/equal employment opportunity program at one institution through cost analysis of personnel, operating expenses, and capital replacement value. Costs incurred in one budget cycle were 0.4 percent of the total institutional budget, most spent indirectly through faculty time, and were found…

78 FR 18996 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... Allergy and Infectious Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the Federal... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Allergy and... review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.855, Allergy...

Evaluation of Undergraduate Teaching at Institutions of Higher Education in China: Problems and Reform

ERIC Educational Resources Information Center

Yukun, Chen

2009-01-01

This paper reviews the achievements of the first cycle of undergraduate teaching evaluation at institutions of higher education in China. Existing problems are identified, and suggestions are made for corresponding reforms for improving the standard and quality of China's undergraduate teaching evaluation.

Quality Assurance in Psychology Programmes across Europe: Survey and Reflections

ERIC Educational Resources Information Center

Marques, J. Frederico

2013-01-01

The present article examines how different institutions that offer psychology study cycles across Europe have adopted quality principles and have taken up particular quality assurance initiatives to raise standards and enhance quality. Thirty-eight different institutions from 32 countries who were members of a European psychology network responded…

Institutional Research in Australasia: Coming of Age or Coming Unstuck?

ERIC Educational Resources Information Center

Hanlon, Martin; Rothery, Michael; Daldy, Rob

2011-01-01

The scope of institutional research (IR) undertaken in Australasian universities is progressively expanding. A traditional focus on student life cycle elements such as enrolment, retention and satisfaction has been complemented for some years now by other areas of focus including research performance and community engagement. More recently,…

Mechatronics Education: From Paper Design to Product Prototype Using LEGO NXT Parts

NASA Astrophysics Data System (ADS)

Lofaro, Daniel M.; Le, Tony Truong Giang; Oh, Paul

The industrial design cycle starts with design then simulation, prototyping, and testing. When the tests do not match the design requirements the design process is started over again. It is important for students to experience this process before they leave their academic institution. The high cost of the prototype phase, due to CNC/Rapid Prototype machine costs, makes hands on study of this process expensive for students and the academic institutions. This document shows that the commercially available LEGO NXT Robot kit is a viable low cost surrogate to the expensive industrial CNC/Rapid Prototype portion of the industrial design cycle.

Different Applications of FORTRACC: From Convective Clouds to thunderstorms and radar fields

NASA Astrophysics Data System (ADS)

Morales, C.; Machado, L. A.

2009-09-01

The algorithm Forecasting and Tracking the Evolution of Cloud Clusters (ForTraCC), Vila et al. (2008), has been employed operationally in Brazil since 2005 to track and forecast the development of convective clouds. This technique depicts the main morphological features of the cloud systems and most importantly it reconstructs its entire life cycle. Based on this information, several relationships that use the area expansion and convective and stratiform fraction are employed to predict the life time duration and cloud area. Because of these features, the civil defense and power companies are using this information to mitigate the damages in the population. Further developments in FORTRACC included the integration of satellite rainfall retrievals, radar fields and thunderstorm initiation. These improvements try to address the following problems: a) most of the satellite rainfall retrievals do not take into account the life cycle stage that it is a key element on defining the rain area and rain intensity; b) by using the life cycle information it is possible to better predict the precipitation pattern observed in the radar fields; c) cloud signatures are associated to the development of systems that have lightning and no lightning activity. During the presentation, an overview of the different applications of FORTRACC will be presented including case studies and evaluation of the technique. Finally, the presentation will address how the users can have access to the algorithm to implement in their institute.

Final Technical Report: Quantification of Uncertainty in Extreme Scale Computations (QUEST)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knio, Omar M.

QUEST is a SciDAC Institute comprising Sandia National Laboratories, Los Alamos National Laboratory, University of Southern California, Massachusetts Institute of Technology, University of Texas at Austin, and Duke University. The mission of QUEST is to: (1) develop a broad class of uncertainty quantification (UQ) methods/tools, and (2) provide UQ expertise and software to other SciDAC projects, thereby enabling/guiding their UQ activities. The Duke effort focused on the development of algorithms and utility software for non-intrusive sparse UQ representations, and on participation in the organization of annual workshops and tutorials to disseminate UQ tools to the community, and to gather inputmore » in order to adapt approaches to the needs of SciDAC customers. In particular, fundamental developments were made in (a) multiscale stochastic preconditioners, (b) gradient-based approaches to inverse problems, (c) adaptive pseudo-spectral approximations, (d) stochastic limit cycles, and (e) sensitivity analysis tools for noisy systems. In addition, large-scale demonstrations were performed, namely in the context of ocean general circulation models.« less

Investigating Viruses during the Transformation of Molecular Biology

PubMed Central

2017-01-01

This Reflections article describes my early work on viral enzymes and the discovery of mRNA capping, how my training in medicine and biochemistry merged as I evolved into a virologist, the development of viruses as vaccine vectors, and how scientific and technological developments during the 1970s and beyond set the stage for the interrogation of nearly every step in the reproductive cycle of vaccinia virus (VACV), a large DNA virus with about 200 genes. The reader may view this article as a work in progress, because I remain actively engaged in research at the National Institutes of Health (NIH) notwithstanding 50 memorable years there. PMID:28154190

Development and Implementation of a Quality Improvement Process for Echocardiographic Laboratory Accreditation.

PubMed

Gilliland, Yvonne E; Lavie, Carl J; Ahmad, Homaa; Bernal, Jose A; Cash, Michael E; Dinshaw, Homeyar; Milani, Richard V; Shah, Sangeeta; Bienvenu, Lisa; White, Christopher J

2016-03-01

We describe our process for quality improvement (QI) for a 3-year accreditation cycle in echocardiography by the Intersocietal Accreditation Commission (IAC) for a large group practice. Echocardiographic laboratory accreditation by the IAC was introduced in 1996, which is not required but could impact reimbursement. To ensure high-quality patient care and community recognition as a facility committed to providing high-quality echocardiographic services, we applied for IAC accreditation in 2010. Currently, there is little published data regarding the IAC process to meet echocardiography standards. We describe our approach for developing a multicampus QI process for echocardiographic laboratory accreditation during the 3-year cycle of accreditation by the IAC. We developed a quarterly review assessing (1) the variability of the interpretations, (2) the quality of the examinations, (3) a correlation of echocardiographic studies with other imaging modalities, (4) the timely completion of reports, (5) procedure volume, (6) maintenance of Continuing Medical Education credits by faculty, and (7) meeting Appropriate Use Criteria. We developed and implemented a multicampus process for QI during the 3-year accreditation cycle by the IAC for Echocardiography. We documented both the process and the achievement of those metrics by the Echocardiography Laboratories at the Ochsner Medical Institutions. We found the QI process using IAC standards to be a continuous educational experience for our Echocardiography Laboratory physicians and staff. We offer our process as an example and guide for other echocardiography laboratories who wish to apply for such accreditation or reaccreditation. © 2016, Wiley Periodicals, Inc.

76 FR 34007 - Draft Regulatory Basis for a Potential Rulemaking on Spent Nuclear Fuel Reprocessing Facilities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... processes are more akin to fuel cycle processes. This framework was established in the 1970's to license the... nuclear power globally and close the nuclear fuel cycle through reprocessing spent fuel and deploying fast... Accounting;'' and a Nuclear Energy Institute white [[Page 34009

Andreae is New Editor of Global Biogeochemical Cycles

NASA Astrophysics Data System (ADS)

Andreae, Meinrat O.

2004-10-01

As the incoming editor of Global Biogeochemical Cycles, I would like to introduce myself and my ideas for the journal to Eos readers and to current and potential GBC authors. I've had a somewhat ``roaming'' scientific evolution, coming from ``straight'' chemistry through hard-rock geochemistry to chemical oceanography, the field in which I did my Ph.D. I taught marine chemistry at Florida State University for a number of years, and developed an interest in ocean/atmosphere interactions and atmospheric chemistry. In 1987 I took on my present job at the Max Planck Institute for Chemistry, in Mainz, Germany, and, after leaving the seacoast, my interests shifted to interactions between the terrestrial biosphere and atmosphere, including the role of vegetation fires. My present focus is on the role of biogenic aerosols and biomass smoke in regulating cloud properties and influencing climate.

Risk assessment of the National Institute of Standards and Technology petroleum crude oil standard water accommodated fraction: further application of a copepod-based, full life-cycle bioassay.

PubMed

Bejarano, Adriana C; Chandler, G Thomas; He, Lijian; Cary, Tawnya L; Ferry, John L

2006-07-01

The U.S. National Institute of Standards and Technology (NIST) petroleum crude oil was used to generate NIST water-accommodated hydrocarbon fractions (WAFs) for standardized assessment of crude oil effects on the copepod Amphiascus tenuiremis. Effects were assessed using a 96-well microplate, full life-cycle test. Briefly, nauplii (age, 24 h) were reared individually to adults (n > or =120 nauplii/treatment) in microplate wells containing 200 microl of treatment solution (seawater control [0%] or 10, 30, 50, or 100% NIST-WAF). Nauplii were monitored through development to adulthood, and mature virgin male:female pairs mated in wells containing original treatments (<30 d). A second bioassay using 0, 10, 30, and 50% WAFs (n > or =60 nauplii/treatment) was conducted to assess the effects of ultraviolet (UV) light on naupliar endpoints (<16 d). In the first experiment, nauplius-to-copepodite survival in exposures to 100% WAF was 27% +/- 6% lower than in controls (92% +/- 1%), but copepodite-to-adult survival was greater than 90% across all treatments. Analysis of development curves showed that nauplii in the 10% WAF developed into copepodites 25% faster, whereas nauplii in the 50 and 100% WAFs developed 17% slower, than controls. Copepodite development into male and female copepods was significantly delayed (2 and 4 d, respectively) in the 100% WAF compared to controls. Although none of the WAF exposures had significant effects on fertilization success or total viable production (p > 0.05), embryo hatching in the 100% WAF was significantly less (70.0% +/- 21.2%) than that in controls (87.0% +/- 19.4%). Results from the UV bioassay showed that relatively short exposures (<14 d) to 30 and 50% WAFs in the presence of UV light caused negative effects on copepod survival and development. Naupliar-stage survival and developmental endpoints were the most sensitive indicators of exposure to the NIST crude oil WAF

The U.S. Climate Change Science Program. Vision for the Program and Highlights of the Scientific Strategic Plan

DTIC Science & Technology

2003-07-01

CH4, N2O, O3, etc. Aerosols Clouds ATMOSPHERIC COMPOSITION WATER CYCLE LAND-USE/ LAND-COVER CHANGE HUMAN CONTRIBUTIONS AND RESPONSES CARBON...Oceanographic Institution. Climate Variability and Change ATMOSPHERIC COMPOSITION CLIMATE VARIABILITY AND CHANGE GLOBAL WATER CYCLE LAND-USE/LAND-COVER CHANGE...their access to and use of water. CCSP-supported research on the global water cycle focuses on how natural processes and human activities influence the

Using Geo-Data Corporately on the Response Phase of Emergency Management

NASA Astrophysics Data System (ADS)

Demir Ozbek, E.; Ates, S.; Aydinoglu, A. C.

2015-08-01

Response phase of emergency management is the most complex phase in the entire cycle because it requires cooperation between various actors relating to emergency sectors. A variety of geo-data is needed at the emergency response such as; existing data provided by different institutions and dynamic data collected by different sectors at the time of the disaster. Disaster event is managed according to elaborately defined activity-actor-task-geodata cycle. In this concept, every activity of emergency response is determined with Standard Operation Procedure that enables users to understand their tasks and required data in any activity. In this study, a general conceptual approach for disaster and emergency management system is developed based on the regulations to serve applications in Istanbul Governorship Provincial Disaster and Emergency Directorate. The approach is implemented to industrial facility explosion example. In preparation phase, optimum ambulance locations are determined according to general response time of the ambulance to all injury cases in addition to areas that have industrial fire risk. Management of the industrial fire case is organized according to defined actors, activities, and working cycle that describe required geo-data. A response scenario was prepared and performed for an industrial facility explosion event to exercise effective working cycle of actors. This scenario provides using geo-data corporately between different actors while required data for each task is defined to manage the industrial facility explosion event. Following developing web technologies, this scenario based approach can be effective to use geo-data on the web corporately.

78 FR 13359 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... Neurological Disorders and Stroke; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... Neurological Disorders and Stroke Initial Review Group Neurological Sciences and Disorders K. Date: March 7... review and funding cycle. Name of Committee: National Institute of Neurological Disorders and Stroke...

78 FR 70063 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; NIDDK Career Awards Review. Date... cycle. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Special...

77 FR 12857 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, PAR11-349 Research Using Subjects from... cycle. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Special...

75 FR 9911 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, Seeding Team Science in Diabetes... cycle. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Special...

76 FR 14672 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-17

... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meetings Pursuant to section 10(d) of the... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; PAR09-247 Ancillary Clinical Studies... review and funding cycle. Name of Committee: National Institute of Diabetes and Digestive and Kidney...

A Typology of Instructors in Higher Education

ERIC Educational Resources Information Center

Nazarova, Inna Borisovna

2008-01-01

In the present article, the relevant and little-studied issue of the typology of instructors in institutions of higher learning is examined using the example of educators conducting the cycle of economic disciplines. In 2003 and 2004 a survey was conducted of the corps of instructors in fourteen higher educational institutions of four cities…

Action Research, Assessment, and Institutional Review Boards (IRB): Conflicting Demands or Productive Tension for the Academic Librarian?

ERIC Educational Resources Information Center

Farrell, Robert

2014-01-01

This article puts forward an "assessment/action research/publication" cycle that integrates aspects of the assessment, research, and Institutional Review Board (IRB) processes to provide academic librarians with a systematic approach for balancing competing workplace demands and give library managers a roadmap for creating a…

76 FR 44597 - National Institute on Alcohol Abuse and Alcoholism; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... Alcohol Abuse and Alcoholism; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Alcohol Abuse... the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.271, Alcohol...

12 CFR 324.205 - VaR-based measure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... risk-based capital requirements. The FDIC-supervised institution must update data sets at least monthly... observation period of at least one year. Data used to determine the VaR-based measure must be relevant to the... portfolio over a full business cycle. An FDIC-supervised institution using this option must update its data...

77 FR 75633 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In... Public Law 92-463. Purpose: The Safety and Occupational Health Study Section will review, discuss, and... cycles pertaining to research issues in occupational safety and health, and allied areas. It is the...

75 FR 26266 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... Occupational Health Study Section (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In...) Public Law 92-463. Purpose: The Safety and Occupational Health Study Section will review, discuss, and... cycles pertaining to research issues in occupational safety and health, and allied areas. It is the...

78 FR 54269 - Electrolytic Manganese Dioxide From Australia and China; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-03

... business cycle for the Domestic Like Product that have occurred in the United States or in the market for... of business proprietary information (BPI) under an administrative protective order (APO) and APO... Institution: If you are a domestic producer, union/worker group, or trade/business association; import/export...

77 FR 39257 - Honey From Argentina and China Institution of Five-Year Reviews Concerning the Countervailing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the...-3088. Limited disclosure of business proprietary information (BPI) under an administrative protective... Institution: If you are a domestic producer, union/worker group, or trade/business association; import/export...

77 FR 53909 - Certain Pasta From Italy and Turkey; Institution of Five-year Reviews Concerning the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for.... Limited disclosure of business proprietary information (BPI) under an administrative protective order (APO... Institution: If you are a domestic producer, union/worker group, or trade/business association; import/export...

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

The Women's Malignancies Branch (WMB), Center for Cancer Research (CCR), National Cancer Institute (NCI) of the National Institutes of Health (NIH) is seeking outstanding postdoctoral candidates interested in studying DNA repair and cell cycle pathways in the context of ovarian cancer and drug resistance. Our broad goal is to explore the molecular and cellular mechanisms of

A U.S.--Russian Industrial Partnership to Develop a Low-Cost IUE-2

NASA Astrophysics Data System (ADS)

Haisch, B.; Robb, P.; Strong, K.; Stern, R.; Schrijver, C. J.; Lemen, J.

1995-12-01

In 18 years as a NASA observatory IUE has generated more than 10(5) spectra and 3000 articles, hosted over 2000 guest observers and launched more than 200 doctoral dissertations. On 1 October 1995 science operations were transferred entirely to ESA. IUE has been a central facility in many multiwavelength programs. It has also supported HST by carrying out projects that require more dedicated time than HST can accomodate, including the ability to carry out uninterrupted observations. Ready access to the UV spectrum has become a routine part of modern astronomical capability, especially with respect to surveying classes of objects and monitoring for variability and cycles. A feasibility study has been initiated in the Solar and Astrophysics Laboratory and the Optical Sciences Laboratory to examine an upgraded IUE-2 to be developed in partnership with the Vavilov State Optical Institute of St. Petersburg, Russia. The Vavilov Institute is the premier space optics facility in the former Soviet Union. The recent ``swords into plowshares'' industrial partnership with Vavilov and cost-effective capabilities involving commercial boosters such as LLV-2 and a version of the Commercial Remote Sensing Satellite (CRSS) bus open innovative new opportunities for developing scientific facilities in space. We are also investigating the economics of a shared launch on the large capacity Proton rocket now operated jointly at the Baikonur complex in Kazakhstan by Lockheed Martin, Khrunichev Enterprises and NPO Energia. The centerpiece of IUE-2 would be a lightweight, advanced techology silicon carbide mirror up to 1.2 m in diameter coupled to modern imaging detectors. The Vavilov Institute has developed a robust ceramic material of remarkable specific rigidity and thermal stability that shows no distortion or hysteresis when thermally cycled between cryogenic and room temperatures. Mirrors are routinely polished to 0.03 waves in the visible. Spectroscopic capabilities would be similar to the current IUE. The CRSS spacecraft provides 10 GBytes of onboard data storage. In the interest of cost-savings, a highly eccentric Exosat-like elliptical orbit is under consideration to provide uninterrupted viewing times of at least 12 hours. This study, now underway, will examine innovative ways in which a science-driven program can be successfully developed and provided to NASA as a purchased commercial product. Inputs are solicited, especially from IUE guest observers and potentially interested IUE-2 users.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grigoriev, Igor; Glass, N. Louise; Martin, Francis

The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) managed by Lawrence Berkeley National Laboratory, is the only user facility in the world devoted to problems of energy and environment. With over one million species, fungi—which include mushrooms—represent one of the largest under-explored branches of the Tree of Life. Together with its community of more than 1,000 scientific collaborators, JGI helping to unlock the secrets encoded in the genomes of fungi to advance a better understanding of the global carbon cycle and to develop new biotechnology products, next-generation biofuels, and medicines.

List of U.S. Army Research Institute Research and Technical Publications for Public Release/Unlimited Distribution. Fiscal Year 2007 (October 1, 2006 to September 30, 2007) With Author Index and Report Titles and Subject Terms Index

DTIC Science & Technology

2008-04-01

Sciences (ARI) SBIR request, the Army Interpersonal Skills Assessment ( AISA ) battery consists of five measures designed to evaluate the interpersonal...placed in positions that require increasing interaction effectiveness. The goal of the AISA is to gauge the Soldier’s aptitude to effectively manage...Phase II of this SBIR effort, the AISA battery underwent a full development cycle including focus group reviews by senior Non-Commissioned Officers

Advanced energy system program

NASA Astrophysics Data System (ADS)

Trester, K.

1989-02-01

The objectives of the program are to design, develop and demonstrate a natural-gas-fueled, highly recuperated, 50 kW Brayton-cycle cogeneration system for commercial, institutional, and multifamily residential applications. Marketing studies have shown that this Advanced Energy System (AES), with its many unique and cost-effective features, has the potential to offer significant reductions in annual electrical and thermal energy costs to the consumer. Specific advantages of the system that result in low cost of ownership are high electrical efficiency (30 percent, HHV), low maintenance, high reliability and long life (20 years).

Improving the Skill Component of Clothing and Textiles among Students in Second Cycle Institutions in Ghana and Its Effect on the Polytechnic Fashion Student. A Case Study of OLA Girls, Mawuko Girls and Mawuli Senior High School in Ho, Ghana

ERIC Educational Resources Information Center

Joana, Amankwa; Selase, Gbadegbe Richard; Selorm, Gbetodeme; Emefa, Agra Florence

2015-01-01

For a nation like Ghana to develop, it is necessary to pay much attention to Vocational and Technical Education. This is so because school programmes that place emphasis on theory courses or humanities are no longer useful to the nation.Graduates who offer such programmes find it very difficult to secure employment in the Ghanaian job market…

Environmental and economic comparisons of the satellite power system and six alternative energy technologies

NASA Astrophysics Data System (ADS)

Whitfield, R. G.; Habegger, L. J.; Levine, E. P.; Tanzman, E.

1981-04-01

The satellite power system (SPS) was compared with alternative systems on life cycle cost and environmental impacts. Environmental and economic effects are evaluated and subdivided into the following issue areas: human health and safety, environmental welfare, resources (land, materials, energy, water, labor), macroeconomics, socioeconomics, and institutional. These evaluations are based on technology characterization data and alternative futures scenarios, developed as part of CDEP. The technologies and the scenarios are described. The cost and performance of the SPS and the alternative technologies provide the basis of the macroeconomic analyses.

The Second-Cycle Reform of 1976 in Retrospect (The Implications of Vocationalism in France).

ERIC Educational Resources Information Center

Geiger, Roger L.

The attempt to give the third and fourth years of university study in France more vocational relevance (the second cycle reform of 1976) is analyzed in relation to the fundamental transformations taking place in French higher education in the areas of access to higher education, institutional diversification, and university governance. Although…

12 CFR 204.133 - Multiple savings deposits treated as a transaction account.

Code of Federal Regulations, 2010 CFR

2010-01-01

... make up to six transfers or withdrawals per month or statement cycle of at least four weeks. The... statement cycle, the depository institution may not classify the account as a savings deposit. If the... order to ensure an independent accounting of the funds held by each trust. (ii) X's Bank's suggestion to...

Charting the Course: Life Cycle Management of Mars Mission Digital Information

NASA Technical Reports Server (NTRS)

Reiz, Julie M.

2003-01-01

This viewgraph presentation reviews the life cycle management of MER Project information. This process was an essential key to the successful launch of the MER Project rovers. Incorporating digital information archive requirements early in the project life cycle resulted in: Design of an information system that included archive metadata, Reduced the risk of information loss through in-process appraisal, Easier transfer of project information to institutional online archive and Project appreciation for preserving information for reuse by future projects

What we were asked to do

NASA Technical Reports Server (NTRS)

1991-01-01

Recommendations are made after 32 interviews, lesson identification, lesson analysis, and mission characteristics identification. The major recommendations are as follows: (1) to develop end-to-end planning and scheduling operations concepts by mission class and to ensure their consideration in system life cycle documentation; (2) to create an organizational infrastructure at the Code 500 level, supported by a Directorate level steering committee with project representation, responsible for systems engineering of end-to-end planning and scheduling systems; (3) to develop and refine mission capabilities to assess impacts of early mission design decisions on planning and scheduling; and (4) to emphasize operational flexibility in the development of the Advanced Space Network, other institutional resources, external (e.g., project) capabilities and resources, operational software and support tools.

Development of Crystallizer for Advanced Aqueous Reprocessing Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tadahiro Washiya; Atsuhiro Shibata; Toshiaki Kikuchi

2006-07-01

Crystallization is one of the remarkable technologies for future fuel reprocessing process that has safety and economical advantages. Japan Atomic Energy Agency (JAEA) (former Japan Nuclear Cycle Development Institute), Mitsubishi Material Corporation and Saitama University have been developing the crystallization process. In previous study, we carried out experimental studies with uranium, MOX and spent fuel conditions, and flowsheet analysis was considered. In association with these studies, an innovative continuous crystallizer and its system was developed to ensure high process performance. From the design study, an annular type continuous crystallizer was selected as the most promising design, and performance was confirmedmore » by small-scale test and engineering scale demonstration at uranium crystallization conditions. In this paper, the design study and the demonstration test results are described. (authors)« less

Ocean Carbon Flux, Transport, and Burial Within the Western and Eastern US Coastal Zones

NASA Technical Reports Server (NTRS)

McWilliams, James C.; Moisan, John R.; Haidvogel, Dale B.; Miller, Arthur J.; Cornuelle, Bruce; Stolzenbach, Keith D.

2004-01-01

This project has been to develop and apply a regional. eddy-resolving circulation and biogeochemistry model of both the western and eastern U.S. coastal regions, capable of simulating the processes that control the carbon cycle. Validation has been by statistical comparison with analyses from various satellite measurements, including those from EOS sensors, as well as from in situ measurements. Sensitivity studies were carried out to investigate how the coastal ecosystem and biogeochemical cycles respond to changes in climate, large-scale eutrophication from indus- trial pollution, and other anthropogenic induced changes. The research has been conducted in collaboration with research groups at UCLA. NASA/GSFC (Wallops), Rutgers, and SIO. Overall. the project was focused on several key modeling issues, each of which tie back into completing the primary task of developing a coastal carbon model for both the eastern and western US. coasts. Individual groups within the entire program are still collaborating to address these specific tasks. These include: implementation of the coupled circulation/biogeochemical model within the U.S. West Coast. including high-resolution, embedded subdomains for the Southern California Bight and Monterey Bay region; development of a biogeochemical model with resolved carbon, nitrogen and oxygen cycles; development of data assimilation techniques for use of satellite data sets; reconfiguration of the model domain to U.S. East Coast; development of coastal forcing fields: development of methods to compare the model against remotely sensed data; and, the test of model sensitivity to environmental conditions. Below, we present a summary of the progress made toward achieving these soak. Because this has been a multi-institutional, collaborative effort, we note the groups involved with particular activities.

Adjuvant Chemoradiation for Gastric Cancer Using Epirubicin, Cisplatin, and 5-Fluorouracil Before and After Three-Dimensional Conformal Radiotherapy With Concurrent Infusional 5-Fluorouracil: A Multicenter Study of the Trans-Tasman Radiation Oncology Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leong, Trevor, E-mail: trevor.leong@petermac.or; Joon, Daryl Lim; Willis, David

Purpose: The INT0116 study has established postoperative chemoradiotherapy as the standard of care for completely resected gastric adenocarcinoma. However, the optimal chemoradiation regimen remains to be defined. We conducted a prospective, multicenter study to evaluate an alternative chemoradiation regimen that combines more current systemic treatment with modern techniques of radiotherapy delivery. Methods and Materials: Patients with adenocarcinoma of the stomach who had undergone an R0 resection were eligible. Adjuvant therapy consisted of one cycle of epirubicin, cisplatin, and 5-FU (ECF), followed by radiotherapy with concurrent infusional 5-FU, and then two additional cycles of ECF. Radiotherapy was delivered using precisely defined,more » multiple-field, three-dimensional conformal techniques. Results: A total of 54 assessable patients were enrolled from 19 institutions. The proportion of patients commencing Cycles 1, 2, and 3 of ECF chemotherapy were 100%, 81%, and 67% respectively. In all, 94% of patients who received radiotherapy completed treatment as planned. Grade 3/4 neutropenia occurred in 66% of patients with 7.4% developing febrile neutropenia. Most neutropenic episodes (83%) occurred in the post-radiotherapy period during cycles 2 and 3 of ECF. Grade 3/4 gastrointestinal toxicity occurred in 28% of patients. In all, 35% of radiotherapy treatment plans contained protocol deviations that were satisfactorily amended before commencement of treatment. At median follow-up of 36 months, the 3-year overall survival rate was estimated at 61.6%. Conclusions: This adjuvant regimen using ECF before and after three-dimensional conformal chemoradiation is feasible and can be safely delivered in a cooperative group setting. A regimen similar to this is currently being compared with the INT0116 regimen in a National Cancer Institute-sponsored, randomized Phase III trial.« less

Marketing Higher Education to New Students. ERIC Higher Education Research Currents.

ERIC Educational Resources Information Center

Trivett, David A.

The enrollment growth in higher education is slowing down. While the decline can be viewed as part of a long-term growth cycle, institutions still need to find students. Institutions may find students by expanding their educational mission, by ascertaining the instructional needs of a variety of students, and by offering the appropriate services…

78 FR 19524 - Polyethylene Terephthalate Film, Sheet, and Strip From India and Taiwan; Institution of Five-Year...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., at 202-205-3088. Limited disclosure of business proprietary information (BPI) under an administrative... to This Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

76 FR 74807 - Stainless Steel Bar From Brazil, India, Japan, and Spain; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO... This Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

77 FR 301 - Corrosion-Resistant Carbon Steel Flat Products From Germany and Korea: Institution of Five-Year...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the...-3088. Limited disclosure of business proprietary information (BPI) under an administrative protective... Institution: If you are a domestic producer, union/worker group, or trade/business association; import/export...

76 FR 45856 - Silicomanganese From Brazil, China, and Ukraine Institution of a Five-Year Review Concerning the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United... Verratti, Deputy Agency Ethics Official, at 202- 205-3088. Limited disclosure of business proprietary... THIS NOTICE OF INSTITUTION: If you are a domestic producer, union/worker group, or trade/business...

76 FR 38688 - Certain Welded Stainless Steel Pipe From Korea and Taiwan; Institution of a Five-Year Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... demand conditions or business cycle for the Domestic Like Product that have occurred in the United States... Carol McCue Verratti, Deputy Agency Ethics Official, at 202- 205-3088. Limited disclosure of business... Institution: If you are a domestic producer, union/worker group, or trade/business association; import/export...

76 FR 31629 - Helical Spring Lock Washers From China and Taiwan; Institution of Five-Year Reviews Concerning...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO... This Notice Of Institution: If you are a domestic producer, union/worker group, or trade/business...

Rigor + Results = Impact: Measuring Impact with Integrity (Invited)

NASA Astrophysics Data System (ADS)

Davis, H. B.; Scalice, D.

2013-12-01

Are you struggling to measure and explain the impact of your EPO efforts? The NASA Astrobiology Institute (NAI) is using an evaluation process to determine the impact of its 15 EPO projects with over 200 activities. What is the current impact? How can it be improved in the future? We have developed a process that preserves autonomy at the project implementation level while still painting a picture of the entire portfolio. The impact evaluation process looks at an education/public outreach activity through its entire project cycle. Working with an external evaluator, education leads: 1) rate the quality/health of an activity in each stage of its cycle, and 2) determine the impact based on the results of the evaluation and the rigor of the methods used. The process has created a way to systematically codify a project's health and its impact, while offering support for improving both impact and how it is measured.

Simulating Aerosol Indirect Effects with Improved Aerosol-Cloud- Precipitation Representations in a Coupled Regional Climate Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yang; Leung, L. Ruby; Fan, Jiwen

This is a collaborative project among North Carolina State University, Pacific Northwest National Laboratory, and Scripps Institution of Oceanography, University of California at San Diego to address the critical need for an accurate representation of aerosol indirect effect in climate and Earth system models. In this project, we propose to develop and improve parameterizations of aerosol-cloud-precipitation feedbacks in climate models and apply them to study the effect of aerosols and clouds on radiation and hydrologic cycle. Our overall objective is to develop, improve, and evaluate parameterizations to enable more accurate simulations of these feedbacks in high resolution regional and globalmore » climate models.« less

Investigating Viruses during the Transformation of Molecular Biology.

PubMed

Moss, Bernard

2017-03-10

This Reflections article describes my early work on viral enzymes and the discovery of mRNA capping, how my training in medicine and biochemistry merged as I evolved into a virologist, the development of viruses as vaccine vectors, and how scientific and technological developments during the 1970s and beyond set the stage for the interrogation of nearly every step in the reproductive cycle of vaccinia virus (VACV), a large DNA virus with about 200 genes. The reader may view this article as a work in progress, because I remain actively engaged in research at the National Institutes of Health (NIH) notwithstanding 50 memorable years there. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Practice-based learning and improvement for institutions: a case report.

PubMed

Kirk, Susan E; Howell, R Edward

2010-12-01

In 2006, the University of Virginia became one of the first academic medical institutions to be placed on probation, after the Accreditation Council for Graduate Medical Education (ACGME) Institutional Review Committee implemented a new classification system for institutional reviews. After University of Virginia reviewed its practices and implemented needed changes, the institution was able to have probation removed and full accreditation restored. Whereas graduate medical education committees and designated institutional officials are required to conduct internal reviews of each ACGME-accredited program midway through its accreditation cycle, no similar requirement exists for institutions. As we designed corrective measures at the University of Virginia, we realized that regularly scheduled audits of the entire institution would have prevented the accumulation of deficiencies. We suggest that institutional internal reviews be implemented to ensure that the ACGME institutional requirements for graduate medical education are met. This process represents practice-based learning and improvement at the institutional level and may prevent other institutions from receiving unfavorable accreditation decisions.

Practice-Based Learning and Improvement for Institutions: A Case Report

PubMed Central

Kirk, Susan E.; Howell, R. Edward

2010-01-01

Background In 2006, the University of Virginia became one of the first academic medical institutions to be placed on probation, after the Accreditation Council for Graduate Medical Education (ACGME) Institutional Review Committee implemented a new classification system for institutional reviews. Intervention After University of Virginia reviewed its practices and implemented needed changes, the institution was able to have probation removed and full accreditation restored. Whereas graduate medical education committees and designated institutional officials are required to conduct internal reviews of each ACGME–accredited program midway through its accreditation cycle, no similar requirement exists for institutions. Learning As we designed corrective measures at the University of Virginia, we realized that regularly scheduled audits of the entire institution would have prevented the accumulation of deficiencies. We suggest that institutional internal reviews be implemented to ensure that the ACGME institutional requirements for graduate medical education are met. This process represents practice-based learning and improvement at the institutional level and may prevent other institutions from receiving unfavorable accreditation decisions. PMID:22132290

The Division III Financial Aid Reporting Process: Findings and Review Results, 2005-06 through 2008-09

ERIC Educational Resources Information Center

National Collegiate Athletic Association (NJ1), 2009

2009-01-01

This report marks the completion of the 2008-09 reporting cycle and the fourth year of the Division III Financial Aid Reporting Program. The report examines findings for all reporting institutions from each of the four reporting cycles, and details the outcomes of the Division III Financial Aid Committee's 2008-09 review process. Four calculations…

The Reorganisation of the Curriculum in Educational Cycles in Codema College: A Positive Step

ERIC Educational Resources Information Center

Vasquez-Martinez, Claudio-Rafael; González-Gonzalez, Felipe; Flores, Francisco; Díaz, Josefina; Cardona-T., Jose-Gerardo; Rendon, Hector; Chavoya, Jorge; Gutiérrez-Cardenas, Sandra-Milena; Álvarez, María-Ines; Torres-Mata, Joaquín; Betancourt-Nuñez, Erik-Moises; Morfín, María; Álvarez, Miguel; Anguiano, Carlos

2017-01-01

The policy of reorganising schools in pedagogical cycles has been restored little by little in the state schools of the city of Bogota. This reform began in the year 2008 in Codema College, which faced a number of challenges, personal as much as institutional. The reform depended upon the participation and engagement of the educational community…

THE EMERGING FOCUS ON LIFE-CYCLE ASSESSMENT IN THE U. S. ENVIRONMENTAL PROTECTION AGENCY: JOURNAL ARTICLE

EPA Science Inventory

NRML-1126A Curran*, M.A. The Emerging Focus on Life-Cycle Assessment in the U. S. Environmental Protection Agency. 3rd Dixy Lee Ray memorial Sym, Washington, DC, 12/29-31/00. Techology: Journal of the Franklin Institute (Moghissi, A.A. (Ed.)) 8:287-290 (2002). EPA/600/J-02/239,...

The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adaptive Designs Accelerating Promising Treatments Into Trials Project

PubMed Central

Guetterman, Timothy C; Fetters, Michael D; Mawocha, Samkeliso; Legocki, Laurie J; Barsan, William G; Lewis, Roger J; Berry, Donald A; Meurer, William J

2017-01-01

Objectives: Clinical trials are complicated, expensive, time-consuming, and frequently do not lead to discoveries that improve the health of patients with disease. Adaptive clinical trials have emerged as a methodology to provide more flexibility in design elements to better answer scientific questions regarding whether new treatments are efficacious. Limited observational data exist that describe the complex process of designing adaptive clinical trials. To address these issues, the Adaptive Designs Accelerating Promising Treatments Into Trials project developed six, tailored, flexible, adaptive, phase-III clinical trials for neurological emergencies, and investigators prospectively monitored and observed the processes. The objective of this work is to describe the adaptive design development process, the final design, and the current status of the adaptive trial designs that were developed. Methods: To observe and reflect upon the trial development process, we employed a rich, mixed methods evaluation that combined quantitative data from visual analog scale to assess attitudes about adaptive trials, along with in-depth qualitative data about the development process gathered from observations. Results: The Adaptive Designs Accelerating Promising Treatments Into Trials team developed six adaptive clinical trial designs. Across the six designs, 53 attitude surveys were completed at baseline and after the trial planning process completed. Compared to baseline, the participants believed significantly more strongly that the adaptive designs would be accepted by National Institutes of Health review panels and non-researcher clinicians. In addition, after the trial planning process, the participants more strongly believed that the adaptive design would meet the scientific and medical goals of the studies. Conclusion: Introducing the adaptive design at early conceptualization proved critical to successful adoption and implementation of that trial. Involving key stakeholders from several scientific domains early in the process appears to be associated with improved attitudes towards adaptive designs over the life cycle of clinical trial development. PMID:29085638

A Physicist's Odyssey in the Public Schools

NASA Astrophysics Data System (ADS)

Blatt, S. Leslie

2004-03-01

My colleagues and I developed our "Discovering Physics" course a dozen years ago based on the best available research on (predominantly pre-college) student learning in the sciences. The hands-on small-group approach we subsequently adopted works quite nicely in the university environment, as well. As a major side benefit, we began consulting with and eventually working closely with teachers in the Worcester Public Schools. Over the years, we developed a regular collaborative cycle: 1.) A curriculum team of Clark faculty and K-12 teachers meets during the academic year for discussions and to design activities built around a "big idea" in the sciences; 2.) A summer institute is offered, for a larger group of teachers, based on the work of the curriculum team; 3.) A "Ways of Knowing in the Sciences" course is offered in the fall for Education Department students, centered on the previously-tested science content coupled with a variety of pedagogical approaches, as well as observations in the schools; and 4.) The cycle resumes with a new team and a different "big idea." The experience continues to be both rewarding and eye-opening.

Perspectives on the neuroscience of alcohol from the National Institute on Alcohol Abuse and Alcoholism.

PubMed

Reilly, Matthew T; Noronha, Antonio; Warren, Kenneth

2014-01-01

Mounting evidence over the last 40 years clearly indicates that alcoholism (alcohol dependence) is a disorder of the brain. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has taken significant steps to advance research into the neuroscience of alcohol. The Division of Neuroscience and Behavior (DNB) was formed within NIAAA in 2002 to oversee, fund, and direct all research areas that examine the effects of alcohol on the brain, the genetic underpinnings of alcohol dependence, the neuroadaptations resulting from excessive alcohol consumption, advanced behavioral models of the various stages of the addiction cycle, and preclinical medications development. This research portfolio has produced important discoveries in the etiology, treatment, and prevention of alcohol abuse and dependence. Several of these salient discoveries are highlighted and future areas of neuroscience research on alcohol are presented. © 2014 Elsevier B.V. All rights reserved.

Cultural implications of mentoring in sub-Saharan Africa: a qualitative study.

PubMed

Sawatsky, Adam P; Parekh, Natasha; Muula, Adamson S; Mbata, Ihunanya; Bui, Thuy

2016-06-01

Although many studies have demonstrated the benefits of mentoring in academic medicine, conceptual understanding has been limited to studies performed in North America and Europe. An ecological model of mentoring in academic medicine can provide structure for a broader understanding of the role of culture in mentoring. The goal of this study was to explore the role of culture in the development and maintenance of mentoring relationships within the context of the University of Malawi College of Medicine. A qualitative study using in-depth, semi-structured interviews and thematic analysis was conducted to explore the meaning of mentorship at the study institution. Criterion sampling was used to identify and recruit medical students, interns, registrars and faculty members. Study team members developed a codebook through open coding and applied it to all interview transcripts. Thematic analysis was used to identify and categorise themes according to an ecological model. A total of 46 participants from two major centres in Malawi were interviewed. Themes were identified within three domains: the intrapersonal; the interpersonal, and the institutional. Intrapersonal themes included Malawian politeness, mentoring needs, and friendliness and willingness to help. Interpersonal themes included understanding the role of the mentor, respect for elders, personal and professional boundaries, and perceptions of others. Institutional themes included the supervisor versus mentor, time pressures, tension about the scope of training, and the mentoring cycle. This study highlights the strengths of and challenges imposed by culture to the provision of mentoring relationships at the study institution. It also highlights the central role of culture in mentoring and proposes an updated model for mentoring in academic medicine. This model can inform future research on mentoring and may serve as a model in the larger effort to provide faculty development in mentoring across sub-Saharan Africa. © 2016 John Wiley & Sons Ltd.

Native American and Hispanic Students: Recruitment, Enrollment, Retention and Graduation Trends; Institutional Performance Measures and Targets; Institutional Action Plans

ERIC Educational Resources Information Center

New Mexico Higher Education Department, 2005

2005-01-01

New Mexicans of Native American and Hispanic ancestry participate less often and less successfully in the higher education system than do other groups. This fact has been demonstrated repeatedly in various studies and is exacerbated by a cycle of poverty, inadequate academic and financial preparation for college, and other issues related to…

CMS Software: Installation Guide and User Manual.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Straut, Christine

A Chemical Inventory Management System (CIMS) is a system or program that is used to track chemicals at a facility or institution. An effective CIMS begins tracking these chemicals at the point of procurement and continues through use and disposal. The management of chemicals throughout the life cycle (procurement to disposal) is a key concept for the secure management of chemicals at any institution.

The role of health professional associations in the promotion of global women's health.

PubMed

Lalonde, André B; Menendez, Hector; Perron, Liette

2010-11-01

Health professional associations, especially those from countries with the highest maternal death burden, have vital roles to play in improving maternal and newborn health and in achieving the Millennium Development Goals 4 and 5. Possessing the knowledge, skills, and influence to positively impact practice at the service delivery level, they can also advocate for change at the policy level and lobby for higher priority and greater investment in the maternal and newborn health field at the national level. The ability of professional associations to assume this leadership is nevertheless contingent on their institutional capacities to achieve planned goals and objectives in support of their organizational mission and strategic priorities. Since 1998, the Society of Obstetricians and Gynaecologists of Canada (SOGC) has been supporting the capacity development efforts of peer professional associations in low-resource countries. SOGC's work in this specific area has led it to develop and pilot an Organization Capacity Improvement Framework (OCIF) that guides professional associations, incrementally, in successive cycles of capacity development. Building on capacity developed within previous capacity-building cycles, this article summarizes and reports on the recent outcomes of the Asociación de Gynecoloígia y Obstetricia de Guatemala's (AGOG) organizational development efforts and the impact they have had in positioning the association as an important contributor in national efforts to improve maternal and newborn health outcomes in the country.

Integrating the Allen Brain Institute Cell Types Database into Automated Neuroscience Workflow.

PubMed

Stockton, David B; Santamaria, Fidel

2017-10-01

We developed software tools to download, extract features, and organize the Cell Types Database from the Allen Brain Institute (ABI) in order to integrate its whole cell patch clamp characterization data into the automated modeling/data analysis cycle. To expand the potential user base we employed both Python and MATLAB. The basic set of tools downloads selected raw data and extracts cell, sweep, and spike features, using ABI's feature extraction code. To facilitate data manipulation we added a tool to build a local specialized database of raw data plus extracted features. Finally, to maximize automation, we extended our NeuroManager workflow automation suite to include these tools plus a separate investigation database. The extended suite allows the user to integrate ABI experimental and modeling data into an automated workflow deployed on heterogeneous computer infrastructures, from local servers, to high performance computing environments, to the cloud. Since our approach is focused on workflow procedures our tools can be modified to interact with the increasing number of neuroscience databases being developed to cover all scales and properties of the nervous system.

Greenhouse Gas Emissions of Beef Cattle Production in the Southern Great Plains

NASA Astrophysics Data System (ADS)

Kannan, N.; Niraula, R.; Saleh, A.; Osei, E.; Cole, A.; Todd, R.; Waldrip, H.; Aljoe, H.

2017-12-01

A five-year USDA-funded study titled "Resilience and vulnerability of beef cattle production in the Southern Great Plains under changing climate, land use, and markets" was initiated as a multi-institutional collaboration involving Texas Institute for Applied Environmental Research (TIAER)—Tarleton State University, United States Department of Agriculture (USDA)—Agricultural Research Service (ARS) in El Reno, Oklahoma, USDA—ARS in Bushland, Texas, Kansas State University, Oklahoma State University, University of Oklahoma, and the Noble Research Institute in Ardmore, Oklahoma. The project goal is to safeguard and promote regional beef production while mitigating its environmental footprint. Conducting a full Life Cycle Analysis (LCA) is one of the major objectives of the study, in addition to field experiments, extension, outreach, and education. Estimation of all the resource use and greenhouse gas emissions are parts of the LCA. A computer model titled Animal Production Life Cycle Analysis Tool (APLCAT) is developed and applied to conduct the LCA on beef cattle production in the study region. The model estimates water use, energy requirements, and emissions of enteric methane, manure methane, nitrous oxide, and carbon dioxide. Also included in the LCA analysis are land-atmospheric exchanges of methane, nitrous oxide, carbon dioxide and the global warming potential. Our study is focused on the cow-calf and stocker phases of beef cattle production. The animal production system in the study region is predominantly forage based with protein and energy supplements when needed. Spring calving typical to the study region. In the cow-calf phase animals typically graze native prairie although introduced pasture grazing is also prevalent. Stockers use winter pasture as the major feed. The results of greenhouse gas emissions summarized per kg of hot carcass weight or animal fed will be presented.

Applying MHD Results to a Scramjet Vehicle

DTIC Science & Technology

2007-02-12

flow, arc formation and extinction, high temperature materials, and non-intrusive gas diagnostics. In this report, results from the DOE Program, and...3) Use of demonstrated non-intrusive diagnostics for plasma and boundary layer measurements, and (4) Testing of high - temperature materials for an MHD...cycle systems with researchers in Eindhoven, The Netherlands, and open-cycle systems with personnel at the High Temperature Institute, Moscow, Russia

Investigation of individual and group variability in estrous cycle characteristics in female Asian elephants (Elephas maximus) at the Oregon Zoo.

PubMed

Glaeser, S S; Hunt, K E; Martin, M S; Finnegan, M; Brown, J L

2012-07-15

Evaluating ovarian cycle activity through longitudinal progestagen monitoring is important for optimizing breeding management of captive elephants and understanding impact of life events (births, deaths, and transfers) on reproductive function. This study summarized serum progestagen profiles for eight Asian mainland elephants (Elephas maximus indicus) and one Bornean elephant (E. maximus borneensis) at the Oregon Zoo over a 20-yr interval, and represents the longest longitudinal dataset evaluated to date. Estrous cycle characteristics were more varied than previously reported for this species, with an overall duration of 12 to 19 wk, luteal phase duration of 4 to 15 wk, and follicular phase duration of 2 to 12 wk. In general, there was more cycle variability across than within individual elephants. Compared with other elephants in the group, the Borneo female exhibited consistently longer cycle lengths, higher progestagen concentrations, and greater cycle variability; however, it is not known if this represents a subspecies or an individual difference. Cycle durations did not appear to change over time or with age, and the first pubertal cycle was similar to subsequent cycles. Variability in duration of the follicular phase was greater than that of the luteal phase. In addition, there was a significant negative relationship between luteal and follicular phase durations, suggesting a possible regulatory role of the follicular phase in maintaining a relatively consistent cycle duration within individuals. Overall, we found these elephants to be highly resilient in that major life events (births, deaths, and changes in herd structure) had minimal effect on cycle dynamics over time. In conclusion, the higher range in cycle phase characteristics is likely because of the larger number of elephants studied and longer duration of longitudinal monitoring, and may be more representative of the captive population as a whole. Furthermore, identification of significant interanimal variability suggests that understanding the complexities of herd reproductive characteristics could facilitate development of more effective institution-specific breeding management strategies. Copyright © 2012 Elsevier Inc. All rights reserved.

EUV Irradiance Inputs to Thermospheric Density Models: Open Issues and Path Forward

NASA Astrophysics Data System (ADS)

Vourlidas, A.; Bruinsma, S.

2018-01-01

One of the objectives of the NASA Living With a Star Institute on "Nowcasting of Atmospheric Drag for low Earth orbit (LEO) Spacecraft" was to investigate whether and how to increase the accuracy of atmospheric drag models by improving the quality of the solar forcing inputs, namely, extreme ultraviolet (EUV) irradiance information. In this focused review, we examine the status of and issues with EUV measurements and proxies, discuss recent promising developments, and suggest a number of ways to improve the reliability, availability, and forecast accuracy of EUV measurements in the next solar cycle.

The role of cGMP signalling in regulating life cycle progression of Plasmodium.

PubMed

Hopp, Christine S; Bowyer, Paul W; Baker, David A

2012-08-01

The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented. Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Determination of silica deposition rates and thresholds applied towards protection of injection reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geothermal Development Associates; Don Michels Associates

1999-07-01

This program was instituted to quantify certain aspects of silica scaling deposition processes at the Miravalles Geothermal Field, Costa Rica. The program objective was to identify the highest temperature at which silica scale will develop from partially evaporated and significantly cooled geothermal liquid under operating conditions. Integral to the study objective was the quantification of certain aspects of silica deposition processes at the Miravalles Geothermal Field, Costa Rica. There, the objective was to reduce the scaling risk associated with adding a bottoming-cycle to generate more electricity from the liquids already being produced.

Multi-objective Optimization on Helium Liquefier Using Genetic Algorithm

NASA Astrophysics Data System (ADS)

Wang, H. R.; Xiong, L. Y.; Peng, N.; Meng, Y. R.; Liu, L. Q.

2017-02-01

Research on optimization of helium liquefier is limited at home and abroad, and most of the optimization is single-objective based on Collins cycle. In this paper, a multi-objective optimization is conducted using genetic algorithm (GA) on the 40 L/h helium liquefier developed by Technical Institute of Physics and Chemistry of the Chinese Academy of Science (TIPC, CAS), steady solutions are obtained in the end. In addition, the exergy loss of the optimized system is studied in the case of with and without liquid nitrogen pre-cooling. The results have guiding significance for the future design of large helium liquefier.

R&D in Vaccines Targeting Neglected Diseases: An Exploratory Case Study Considering Funding for Preventive Tuberculosis Vaccine Development from 2007 to 2014

PubMed Central

Costa Barbosa Bessa, Theolis; Santos de Aragão, Erika; Medeiros Guimarães, Jane Mary

2017-01-01

Based on an exploratory case study regarding the types of institutions funding the research and development to obtain new tuberculosis vaccines, this article intends to provoke discussion regarding the provision of new vaccines targeting neglected disease. Although our findings and discussion are mainly relevant to the case presented here, some aspects are more generally applicable, especially regarding the dynamics of development in vaccines to prevent neglected diseases. Taking into account the dynamics of innovation currently seen at work in the vaccine sector, a highly concentrated market dominated by few multinational pharmaceutical companies, we feel that global PDP models can play an important role throughout the vaccine development cycle. In addition, the authors call attention to issues surrounding the coordination of actors and resources in the research, development, manufacturing, and distribution processes of vaccine products arising from PDP involvement. PMID:28133608

Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study

PubMed Central

Mumford, Sunni L.; Dasharathy, Sonya S.; Pollack, Anna Z.; Perkins, Neil J.; Mattison, Donald R.; Cole, Stephen R.; Wactawski-Wende, Jean; Schisterman, Enrique F.

2013-01-01

STUDY QUESTION Do uric acid levels across the menstrual cycle show associations with endogenous estradiol (E2) and reproductive hormone concentrations in regularly menstruating women? SUMMARY ANSWER Mean uric acid concentrations were highest during the follicular phase, and were inversely associated with E2 and progesterone, and positively associated with FSH. WHAT IS KNOWN ALREADY E2 may decrease serum levels of uric acid in post-menopausal women; however, the interplay between endogenous reproductive hormones and uric acid levels among regularly menstruating women has not been elucidated. STUDY DESIGN, SIZE, DURATION The BioCycle study was a prospective cohort study conducted at the University at Buffalo research centre from 2005 to 2007, which followed healthy women for one (n = 9) or 2 (n = 250) menstrual cycle(s). PARTICIPANTS/MATERIALS, SETTING, METHODS Participants were healthy women aged 18–44 years. Hormones and uric acid were measured in serum eight times each cycle for up to two cycles. Marginal structural models with inverse probability of exposure weights were used to evaluate the associations between endogenous hormones and uric acid concentrations. MAIN RESULTS AND THE ROLE OF CHANCE Uric acid levels were observed to vary across the menstrual cycle, with the lowest levels observed during the luteal phase. Every log-unit increase in E2 was associated with a decrease in uric acid of 1.1% (β = −0.011; 95% confidence interval (CI): −0.019, −0.004; persistent-effects model), and for every log-unit increase in progesterone, uric acid decreased by ∼0.8% (β = −0.008; 95% CI: −0.012, −0.004; persistent-effects model). FSH was positively associated with uric acid concentrations, such that each log-unit increase was associated with a 1.6% increase in uric acid (β = 0.016; 95% CI: 0.005, 0.026; persistent-effects model). Progesterone and FSH were also associated with uric acid levels in acute-effects models. Of 509 cycles, 42 were anovulatory (8.3%). Higher uric acid levels were associated with increased odds of anovulation (odds ratio 2.39, 95% CI: 1.25, 4.56). LIMITATIONS, REASONS FOR CAUTION The change in uric acid levels among this cohort of healthy women was modest, and analysis was limited to two menstrual cycles. The women in this study were healthy and regularly menstruating, and as such there were few women with high uric acid levels and anovulatory cycles. WIDER IMPLICATIONS OF THE FINDINGS These findings demonstrate the importance of taking menstrual cycle phase into account when measuring uric acid in premenopausal women, and confirm the hypothesized beneficial lowering effects of endogenous E2 on uric acid levels. These findings suggest that there could be an underlying association affecting both sporadic anovulation and high uric acid levels among young, regularly menstruating women. Further studies are needed to confirm these findings and elucidate the connection between uric acid and reproductive and later cardiovascular health. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract # HHSN275200403394C). No competing interests declared. PMID:23562957

Ozone (Environmental Health Student Portal)

MedlinePlus

... Environmental Protection Agency) - Describes ozone depletion effects on human health, plants, marine ecosystems, and biogeochemical cycles. Ozone (Tox ... Medicine National Institutes of Health U.S. Department of Health and Human Services

Moving mountains together: strategic community leadership and systems change.

PubMed

Nissen, Laura Burney; Merrigan, Daniel M; Kraft, M Katherine

2005-01-01

Traditional leadership practice frameworks to guide systems change often fall short in today's practice environment. Reclaiming Futures is a national initiative to create an integrated, comprehensive, seamless system of care for teens with substance abuse problems involved in juvenile justice. It uses leadership and systems reform strategies to improve public health institutions. The premise is that interruption of the destructive cycle of drugs and delinquency can only be attained through the cultivation of shared strategic leadership. This article presents the limitations of traditional practice frameworks of leadership, describes the theory of this new approach to leadership development, and clarifies collaborative leadership and system change. The article includes an example of the framework in action, a discussion of lessons learned, and recommendations for community leadership development initiatives.

The Nitrogen Footprint Tool for Institutions: Comparing Results for a Diverse Group of Institutions

NASA Astrophysics Data System (ADS)

Castner, E.; Leach, A. M.; Galloway, J. N.; Hastings, M. G.; Lantz-Trissel, J.; Leary, N.; Kimiecik, J.; de la Reguera, E.

2015-12-01

Anthropogenic production of reactive nitrogen (Nr) has drastically altered the nitrogen cycle over the past few decades by causing it to accumulate in the environment. A nitrogen footprint (NF) estimates the amount of Nr released to the environment as a result of an entity's activities. The Nitrogen Footprint Tool (NFT) for universities and institutions provides a standardized method for quantifying the NF for the activities and operations of these entities. The NFT translates data on energy use, food purchasing, sewage treatment, and fertilizer use to the amount of Nr lost to the environment using NOx and N2O emission factors, virtual nitrogen factors (VNFs) for food production, N reduction rates from wastewater treatment, and nitrogen uptake factors for fertilizer. As part of the Nitrogen Footprint Project supported by the EPA, seven institutions (colleges, universities, and research institutions) have completed NFT assessments: University of Virginia, University of New Hampshire, Brown University, Dickinson College, Colorado State University, Eastern Mennonite University, and the Marine Biological Laboratory. The results of these assessments reveal the magnitude of impacts on the global nitrogen cycle by different activities and sectors, and will allow these institutions to set NF reduction goals along with management decisions based on scenarios and projections in the NFT. The trends revealed in early analysis of the results include geographic differences based on regional energy sources and local sewage treatment, as well as operational differences that stem from institution type and management. As an example of the impact of management, the amount and type of food served directly impacts the food production NF, which is a large percentage of the total NF for all institutions (35-75%). Comparison of these first NF results will shed light on the primary activities of institutions that add Nr to the environment and examine the differences between them.

Report on GeoData 2011 Workshop - Data Life Cycle, Integration and Citation

NASA Astrophysics Data System (ADS)

Signell, R.; Fox, P.

2012-04-01

The U.S. GeoData 2011 was inspired by a joint NSF-USGS identification of the need to hear from the broader 'geo' community on a variety of data related matters. While increasing attention needed to be paid to full life cycle of data, in the process of preparing and scoping the workshop two other hot issues were identified: integration and citation, giving the workshop three subject areas to delve into as well as to explore connections among them. Invited participants were drawn from all 'Geo' disciplines, and beyond, from information, computer and library science, from academia, agency and commercial organizations, and from student to senior faculty/ administrators. The workshop diversity provided a rich exchange of ideas, experiences and challenges for GeoData. Many key findings and recommendations have been extracted from the detail breakout discussions and syntheses during and after the workshop. Topical categories included: metadata, standards, standards-based tools, culture, collaboration and workforce. Key points that cut across all three-subject areas were: - A shift is needed within agencies to provide longer-term funding support, for communities to come together, remain coherent and to enable data stewardship, integration and citation within their communities and across to other communities (to the extent possible). - Agencies like USGS, NASA and NOAA must also play a key role in sustaining geoscience cyberinfrastructure by moving research advances into operations. - Community-wide standards and practices should build from demonstrated successes, be widely disseminated, and tools need to be developed to support them. - Education is critical to broader adoption. Marketing studies need to be conducted to provide the business case for full stewardship, integration and citation, and incentives are needed to encourage everyone to participate in making data integratable, citable, etc. While technology gaps are still evident across the three topic areas, there is recognition that human factors dominate, and often limit progress and effectiveness. Organizational and resource factors that would lead to a solid understanding of the business case behind, for example, making data preservable and integratable, come at a cost that is not well documented or supported when resource (funds and people) decisions are made. This presentation will report on the data life cycle findings and recommendations from the workshop. Recommendations: - Create an interagency working group to foster data life cycle management practices, support coordination and informatics science initiatives, and to develop a high level shared vision and strategy for data life cycle management - Create and fund a coordination office that works with the "working" level of agencies and academic institutions to facilitate working groups and workshops, adoption of standards and tools, and creation of sustainable archives - Support and actively participate in existing coordination groups, and create where needed, new communities of practice in data life cycle management across agencies, academic institutions, and the private sector - Establish an NSF working group to address the issue of incentives and cultural change needed to facilitate implementation of data life-cycle management http://tw.rpi.edu/web/Workshop/Community/GeoData2011, #geodata2011

Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome

PubMed Central

Diamond, Michael P.; Kruger, Michael; Santoro, Nanette; Zhang, Heping; Casson, Peter; Schlaff, William; Coutifaris, Christos; Brzyski, Robert; Christman, Gregory; Carr, Bruce R.; McGovern, Peter G.; Cataldo, Nicholas A.; Steinkampf, Michael P.; Gosman, Gabriella G.; Nestler, John E.; Carson, Sandra; Myers, Evan E.; Eisenberg, Esther; Legro, Richard S.

2013-01-01

Objective To estimate whether progestin-induced endometrial shedding, prior to ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCOS). Methods A secondary analysis of the data from 626 women with PCOS from the National Institutes of Child Health and Human Development Cooperative Reproductive Medicine Network trial was performed. Women had been randomized to up to six cycles of clomiphene citrate alone, metformin alone, or clomiphene citrate plus metformin. Women were assessed for occurrence of ovulation, conception, and live birth in relation to prior bleeding episodes (after either ovulation or exogenous progestin-induced withdrawal bleed). Results While ovulation rates were higher in cycles preceded by spontaneous endometrial shedding than after anovulatory cycles (with or without prior progestin withdrawal), both conception and live birth rates were significantly higher after anovulatory cycles without progestin-induced withdrawal bleeding (live birth per cycle: spontaneous menses 2.2%; anovulatory with progestin withdrawal 1.6%; anovulatory without progestin withdrawal 5.3%; p<0.001). The difference was more marked when rate was calculated per ovulation (live birth per ovulation: spontaneous menses 3.0%; anovulatory with progestin withdrawal 5.4%; anovulatory without progestin withdrawal 19.7%; p < .001). Conclusion Conception and live birth rates are lower in women with PCOS after a spontaneous menses or progestin-induced withdrawal bleeding as compared to anovulatory cycles without progestin withdrawal. The common clinical practice of inducing endometrial shedding with progestin prior to ovarian stimulation may have an adverse effect on rates of conception and live birth in anovulatory women with PCOS. PMID:22525900

Aerosol Modeling for the Global Model Initiative

NASA Technical Reports Server (NTRS)

Weisenstein, Debra K.; Ko, Malcolm K. W.

2001-01-01

The goal of this project is to develop an aerosol module to be used within the framework of the Global Modeling Initiative (GMI). The model development work will be preformed jointly by the University of Michigan and AER, using existing aerosol models at the two institutions as starting points. The GMI aerosol model will be tested, evaluated against observations, and then applied to assessment of the effects of aircraft sulfur emissions as needed by the NASA Subsonic Assessment in 2001. The work includes the following tasks: 1. Implementation of the sulfur cycle within GMI, including sources, sinks, and aqueous conversion of sulfur. Aerosol modules will be added as they are developed and the GMI schedule permits. 2. Addition of aerosol types other than sulfate particles, including dust, soot, organic carbon, and black carbon. 3. Development of new and more efficient parameterizations for treating sulfate aerosol nucleation, condensation, and coagulation among different particle sizes and types.

Development of a global backscatter model for NASA's laser atmospheric wind sounder

NASA Technical Reports Server (NTRS)

Bowdle, David; Collins, Laurie; Mach, Douglas; Mcnider, Richard; Song, Aaron

1992-01-01

During the Contract Period April 1, 1989, to September 30, 1992, the Earth Systems Science Laboratory (ESSL) in the Research Institute at the University of Alabama in Huntsville (UAH) conducted a program of basic research on atmospheric backscatter characteristics, leading to the development of a global backscatter model. The ESSL research effort was carried out in conjunction with the Earth System Observing Branch (ES43) at the National Aeronautics and Space Administration (NASA) Marshall Space Flight Center, as part of NASA Contract NAS8-37585 under the Atmospheric Dynamics Program at NASA Headquarters. This research provided important inputs to NASA's GLObal Backscatter Experiment (GLOBE) program, especially in the understanding of global aerosol life cycles, and to NASA's Doppler Lidar research program, especially the development program for their prospective space-based Laser Atmospheric Wind Sounder (LAWS).

Engineering and physical sciences in oncology: challenges and opportunities.

PubMed

Mitchell, Michael J; Jain, Rakesh K; Langer, Robert

2017-11-01

The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas.

Utilities and manufacturers: Pioneering partnerships and their lessons for the 21st century

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartsch, C.; DeVaul, D.

1994-12-31

Manufacturers who, in partnership with utilities, improved their production process through energy efficiency and waste minimization strategies are discussed. Frequently these investments changed the corporate culture and resulted in a commitment to continuous improvement that may ensure the industrialists adapt to a rapidly evolving marketplace. The Northeast-Midwest Institute`s work to record these case studies developed out of the observation that older manufacturing facilities too often are run until no longer competitive, then closed, and new plants are built somewhere else - increasingly overseas. Unemployment, poverty, and cycles of economic and social deterioration too often follow if a new economic basemore » cannot be created. At the same time, inefficient industrial plants tend to emit large quantities of waste materials; industry produces more than 600 million tons of hazardous wastes and approximately 13 billion tons of solid wastes each year. To help identify how to avoid such pitfalls, the Institute sought out manufacturers who modernized successfully. Case studies are presented that show that utilities often are instrumental in catalyzing change in their industrial partners. In fact, much can be gained from utilities and industries working together. Many manufacturers need technical and financial assistance to maintain peak productivity.« less

Architecture for nuclear energy in the 21st century

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arthu, E.D.; Cunningham, P.T.; Wagner, R.L. Jr.

1999-02-21

Global and regional scenarios for future energy demand have been assessed from the perspectives of nuclear materials management. From these the authors propose creation of a nuclear fuel cycle architecture which maximizes inherent protection of plutonium and other nuclear materials. The concept also provides technical and institutional flexibility for transition into other fuel cycle systems, particularly those involving breeder reactors. The system, its implementation timeline, and overall impact are described in the paper.

Trauma Quality Improvement: Reducing Triage Errors by Automating the Level Assignment Process.

PubMed

Stonko, David P; O Neill, Dillon C; Dennis, Bradley M; Smith, Melissa; Gray, Jeffrey; Guillamondegui, Oscar D

2018-04-12

Trauma patients are triaged by the severity of their injury or need for intervention while en route to the trauma center according to trauma activation protocols that are institution specific. Significant research has been aimed at improving these protocols in order to optimize patient outcomes while striving for efficiency in care. However, it is known that patients are often undertriaged or overtriaged because protocol adherence remains imperfect. The goal of this quality improvement (QI) project was to improve this adherence, and thereby reduce the triage error. It was conducted as part of the formal undergraduate medical education curriculum at this institution. A QI team was assembled and baseline data were collected, then 2 Plan-Do-Study-Act (PDSA) cycles were implemented sequentially. During the first cycle, a novel web tool was developed and implemented in order to automate the level assignment process (it takes EMS-provided data and automatically determines the level); the tool was based on the existing trauma activation protocol. The second PDSA cycle focused on improving triage accuracy in isolated, less than 10% total body surface area burns, which we identified to be a point of common error. Traumas were reviewed and tabulated at the end of each PDSA cycle, and triage accuracy was followed with a run chart. This study was performed at Vanderbilt University Medical Center and Medical School, which has a large level 1 trauma center covering over 75,000 square miles, and which sees urban, suburban, and rural trauma. The baseline assessment period and each PDSA cycle lasted 2 weeks. During this time, all activated, adult, direct traumas were reviewed. There were 180 patients during the baseline period, 189 after the first test of change, and 150 after the second test of change. All were included in analysis. Of 180 patients, 30 were inappropriately triaged during baseline analysis (3 undertriaged and 27 overtriaged) versus 16 of 189 (3 undertriaged and 13 overtriaged) following implementation of the web tool (p = 0.017 for combined errors). Overtriage dropped further from baseline to 10/150 after the second test of change (p = 0.005). The total number of triaged patients dropped from 92.3/week to 75.5/week after the second test of change. There was no statistically significant change in the undertriage rate. The combination of web tool implementation and protocol refinement decreased the combined triage error rate by over 50% (from 16.7%-7.9%). We developed and tested a web tool that improved triage accuracy, and provided a sustainable method to enact future quality improvement. This web tool and QI framework would be easily expandable to other hospitals. Copyright © 2018 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Tungsten joining with copper alloy and its high heat load performance

NASA Astrophysics Data System (ADS)

Liu, Xiang; Lian, Youyun; Chen, Lei; Cheng, Zengkui; Chen, Jiming; Duan, Xuru; Song, Jioupeng; Yu, Yang

2014-12-01

W-CuCrZr joining technology by using low activation Cu-Mn filler metal was developed at Southwestern Institute of Physics (SWIP) for the manufacturing of divertor components of fusion experiment devices. In addition, a fast W coating technology by chemical vapor deposition (CVD) was also developed and CVD-W/CuCrZr and CVD-W/C mockups with a W coating thickness of 2 mm were prepared. In order to assess their high heat flux (HHF) performances, a 60 kW Electron-beam Material testing Scenario (EMS-60) equipped with a 150 keV electron beam welding gun was constructed at SWIP. Experimental results indicated that brazed W/CuCrZr mockups can withstand 8 MW/m2 heat flux for 1000 cycles without visible damages and CVD-W/CuCrZr mockups with W-Cu gradient interface can survive 1000 cycles under 11 MW/m2 heat flux. An ultrasonic inspection method for non-destructive tests (NDT) of brazed W/CuCrZr mockups was established and 2 mm defect can be detected. Infinite element analysis and heat load tests indicated that 5 mm defect had less noticeable influence on the heat transfer.

Enterprise SRS: leveraging ongoing operations to advance nuclear fuel cycles research and development programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murray, A.M.; Marra, J.E.; Wilmarth, W.R.

2013-07-01

The Savannah River Site (SRS) is re-purposing its vast array of assets (including H Canyon - a nuclear chemical separation plant) to solve issues regarding advanced nuclear fuel cycle technologies, nuclear materials processing, packaging, storage and disposition. The vehicle for this transformation is Enterprise SRS which presents a new, radical view of SRS as a united endeavor for 'all things nuclear' as opposed to a group of distinct and separate entities with individual missions and organizations. Key among the Enterprise SRS strategic initiatives is the integration of research into SRS facilities but also in other facilities in conjunction with on-goingmore » missions to provide researchers from other national laboratories, academic institutions, and commercial entities the opportunity to demonstrate their technologies in a relevant environment and scale prior to deployment. To manage that integration of research demonstrations into site facilities, a center for applied nuclear materials processing and engineering research has been established in SRS.« less

Cyclic Hardness Test PHYBALCHT: A New Short-Time Procedure to Estimate Fatigue Properties of Metallic Materials

NASA Astrophysics Data System (ADS)

Kramer, Hendrik; Klein, Marcus; Eifler, Dietmar

Conventional methods to characterize the fatigue behavior of metallic materials are very time and cost consuming. That is why the new short-time procedure PHYBALCHT was developed at the Institute of Materials Science and Engineering at the University of Kaiserslautern. This innovative method requires only a planar material surface to perform cyclic force-controlled hardness indentation tests. To characterize the cyclic elastic-plastic behavior of the test material the change of the force-indentation-depth-hysteresis is plotted versus the number of indentation cycles. In accordance to the plastic strain amplitude the indentation-depth width of the hysteresis loop is measured at half minimum force and is called plastic indentation-depth amplitude. Its change as a function of the number of cycles of indentation can be described by power-laws. One of these power-laws contains the hardening-exponentCHT e II , which correlates very well with the amount of cyclic hardening in conventional constant amplitude fatigue tests.

The NCI Thesaurus quality assurance life cycle.

PubMed

de Coronado, Sherri; Wright, Lawrence W; Fragoso, Gilberto; Haber, Margaret W; Hahn-Dantona, Elizabeth A; Hartel, Francis W; Quan, Sharon L; Safran, Tracy; Thomas, Nicole; Whiteman, Lori

2009-06-01

The National Cancer Institute Enterprise Vocabulary Services (NCI EVS) uses a wide range of quality assurance (QA) techniques to maintain and extend NCI Thesaurus (NCIt). NCIt is a reference terminology and biomedical ontology used in a growing number of NCI and other systems that extend from translational and basic research through clinical care to public information and administrative activities. Both automated and manual QA techniques are employed throughout the editing and publication cycle, which includes inserting and editing NCIt in NCI Metathesaurus. NCI EVS conducts its own additional periodic and ongoing content QA. External reviews, and extensive evaluation by and interaction with EVS partners and other users, have also played an important part in the QA process. There have always been tensions and compromises between meeting the needs of dependent systems and providing consistent and well-structured content; external QA and feedback have been important in identifying and addressing such issues. Currently, NCI EVS is exploring new approaches to broaden external participation in the terminology development and QA process.

Harnessing the Flow of Data from Fungi at JGI

ScienceCinema

Grigoriev, Igor; Glass, N. Louise; Martin, Francis; Turgeon, Gillian; Spatafora, Joey; Berka, Randy

2018-06-12

The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) managed by Lawrence Berkeley National Laboratory, is the only user facility in the world devoted to problems of energy and environment. With over one million species, fungi—which include mushrooms—represent one of the largest under-explored branches of the Tree of Life. Together with its community of more than 1,000 scientific collaborators, JGI helping to unlock the secrets encoded in the genomes of fungi to advance a better understanding of the global carbon cycle and to develop new biotechnology products, next-generation biofuels, and medicines.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rebecca E. Smith

Internationally, the nuclear industry is represented by both commercial utilities and research institutions. Over the past two decades many of these entities have had to relocate inventories of spent nuclear fuel from underwater storage to dry storage. These efforts were primarily prompted by two factors: insufficient storage capacity (potentially precipitated by an open-ended nuclear fuel cycle) or deteriorating quality of existing underwater facilities. The intent of developing this bibliography is to assess what issues associated with fuel drying have been identified, to consider where concerns have been satisfactorily addressed, and to recommend where additional research would offer the most valuemore » to the commercial industry and the U. S. Department of Energy.« less

Final Report on Institutional Computing Project s15_hilaserion, “Kinetic Modeling of Next-Generation High-Energy, High-Intensity Laser-Ion Accelerators as an Enabling Capability”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albright, Brian James; Yin, Lin; Stark, David James

This proposal sought of order 1M core-hours of Institutional Computing time intended to enable computing by a new LANL Postdoc (David Stark) working under LDRD ER project 20160472ER (PI: Lin Yin) on laser-ion acceleration. The project was “off-cycle,” initiating in June of 2016 with a postdoc hire.

Soil Carbon and Nitrogen Cycle Modeling

NASA Astrophysics Data System (ADS)

Woo, D.; Chaoka, S.; Kumar, P.; Quijano, J. C.

2012-12-01

Second generation bioenergy crops, such as miscanthus (Miscantus × giganteus) and switchgrass (Panicum virgatum), are regarded as clean energy sources, and are an attractive option to mitigate the human-induced climate change. However, the global climate change and the expansion of perennial grass bioenergy crops have the power to alter the biogeochemical cycles in soil, especially, soil carbon storages, over long time scales. In order to develop a predictive understanding, this study develops a coupled hydrological-soil nutrient model to simulate soil carbon responses under different climate scenarios such as: (i) current weather condition, (ii) decreased precipitation by -15%, and (iii) increased temperature up to +3C for four different crops, namely miscanthus, switchgrass, maize, and natural prairie. We use Precision Agricultural Landscape Modeling System (PALMS), version 5.4.0, to capture biophysical and hydrological components coupled with a multilayer carbon and ¬nitrogen cycle model. We apply the model at daily time scale to the Energy Biosciences Institute study site, located in the University of Illinois Research Farms, in Urbana, Illinois. The atmospheric forcing used to run the model was generated stochastically from parameters obtained using available data recorded in Bondville Ameriflux Site. The model simulations are validated with observations of drainage and nitrate and ammonium concentrations recorded in drain tiles during 2011. The results of this study show (1) total soil carbon storage of miscanthus accumulates most noticeably due to the significant amount of aboveground plant carbon, and a relatively high carbon to nitrogen ratio and lignin content, which reduce the litter decomposition rate. Also, (2) the decreased precipitation contributes to the enhancement of total soil carbon storage and soil nitrogen concentration because of the reduced microbial biomass pool. However, (3) an opposite effect on the cycle is introduced by the increased temperature. The simulation results obtained in this study show differences in the soil biogeochemistry induced by the different crops analyzed. Considering the spatial scale at which this crops are cultivated this results suggest there could be important implications in the carbon and nitrogen cycle and indirect feedbacks on climate change. This study also helps us understand the future soil mineral cycle, and ensure a sustainable transition to bioenergy crops.

Slow-sand water filter: Design, implementation, accessibility and sustainability in developing countries

PubMed Central

Clark, Peter A.; Pinedo, Catalina Arango; Fadus, Matthew; Capuzzi, Stephen

2012-01-01

Summary The need for clean water has risen exponentially over the globe. Millions of people are affected daily by a lack of clean water, especially women and children, as much of their day is dedicated to collecting water. The global water crisis not only has severe medical implications, but social, political, and economic consequences as well. The Institute of Catholic Bioethics at Saint Joseph’s University has recognized this, and has designed a slow-sand water filter that is accessible, cost-effective, and sustainable. Through the implementation of the Institute’s slow-sand water filter and the utilization of microfinancing services, developing countries will not only have access to clean, drinkable water, but will also have the opportunity to break out of a devastating cycle of poverty. PMID:22739748

Water scarcity: moving beyond indexes to innovative institutions.

PubMed

Jarvis, W Todd

2013-01-01

Water scarcity is a media darling often times described as a trigger of conflict in arid regions, a by-product of human influences ranging from desertification to climate change, or a combination of natural- and human-induced changes in the water cycle. A multitude of indexes have been developed over the past 20 years to define water scarcity to map the "problem" and guide international donor investment. Few indexes include groundwater within the metrics of "scarcity." Institutional communication contributes to the recognition of local or regional water scarcity. However, evaluations that neglect groundwater resources may incorrectly define conditions as scarce. In cases where there is a perception of scarcity, the incorporation of groundwater and related storage in aquifers, political willpower, new policy tools, and niche diplomacy often results in a revised status, either reducing or even eliminating the moniker locally. Imaginative conceptualization and innovative uses of aquifers are increasingly used to overcome water scarcity. © 2013, National Ground Water Association.

Sunitinib-induced thyrotoxicosis - a not so rare entity.

PubMed

Jazvić, Marijana; Prpić, Marin; Jukić, Tomislav; Murgić, Jure; Jakšić, Blanka; Kust, Davor; Prgomet, Angela; Bolanča, Ante; Kusić, Zvonko

2015-01-01

The tyrosine kinase inhibitor (TKI) sunitinib malate is nowadays a standard first-line treatment option for patients with metastatic clear-cell renal cell carcinoma (mRCC). The aim of this study was to evaluate the incidence and clinical course of thyrotoxicosis in our cohort of patients treated with sunitinib. Medical records of all patients treated with first-line sunitinib for mRCC at our Institution between November 2008 and March 2014 were retrospectively reviewed. Thyroid function was assessed after every 2 cycles of therapy, during the 2 weeks off period. Out of the 62 included patients, hypothyroidism has developed during therapy in 12 patients (19%) and it was preceded by thyrotoxicosis in 2 (3.2%). Sunitinib-induced thyrotoxicosis (SIT), a not so rare entity, was followed by hypothyroidism. The patterns of occurrence and possible significance of SIT, as predictive marker of better treatment response to sunitinib, need to be validated in further studies. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Remote Sensing of Air Pollution from Geo with GEMS and TEMPO

NASA Astrophysics Data System (ADS)

Lasnik, J.; Nicks, D. K., Jr.; Baker, B.; Canova, B.; Chance, K.; Liu, X.; Suleiman, R. M.; Pennington, W. F.; Flittner, D. E.; Al-Saadi, J. A.; Rosenbaum, D. M.

2017-12-01

The Geostationary Environmental Monitoring System (GEMS) and Tropospheric Emissions: Monitoring of Pollution (TEMPO) instruments will provide a new capability for the understanding of air quality and pollution. Ball Aerospace is the instrument developer. The GEMS and TEMPO instruments use well-proven remote sensing techniques and take advantage of a geostationary orbit to take hourly measurements of the same geographical area. The high spatial and temporal resolution of these instruments will allow for measurements of the complex diurnal cycle of pollution driven by the combination of photochemistry, chemical composition and the dynamic nature of the atmosphere. Status of the manufacturing, test and calibration efforts will be presented.The GEMS instrument is being built for the Korea Aerospace Research Institute and their customer the National Institute of Environmental Research (NIER). The TEMPO instrument is being built for NASA under the Earth Venture Instrument EVI Program. NASA Langley Research Center (LaRC) is the managing center and the Principle Investigator (PI) is Kelly Chance of the Smithsonian Astrophysical Observatory (SAO).

Some recent developments in sheet metal forming for production of lightweight automotive parts

NASA Astrophysics Data System (ADS)

Tisza, M.; Lukács, Zs; Kovács, P.; Budai, D.

2017-09-01

Low cost manufacturing in the automotive industry is one of the main targets due to the ever increasing global competition among car manufacturers all over the World. Sheet metal forming is one of the most important key technologies in the automotive industry; therefore the elaboration of new, innovative low cost manufacturing processes is one of the main objectives in sheet metal forming as well. In 2015 with the initiative of the Imperial College London a research consortium was established under the umbrella Low Cost Materials Processing Technologies for Mass Production of Lightweight Vehicles. The primary aim of this project is to provide affordable low cost weight reduction in mass production of vehicles considering the entire life-cycle. In this project, 19 European Institutions (Universities and Research Institutions) from 9 European countries are participating with the above targets. The University of Miskolc is one of the members of this research Consortium. In this paper, some preliminary results with the contributions of the University of Miskolc will be introduced.

A community translational research pilot grants program to facilitate community--academic partnerships: lessons from Colorado's clinical translational science awards.

PubMed

Main, Deborah S; Felzien, Maret C; Magid, David J; Calonge, B Ned; O'Brien, Ruth A; Kempe, Allison; Nearing, Kathryn

2012-01-01

National growth in translational research has increased the need for practical tools to improve how academic institutions engage communities in research. One used by the Colorado Clinical and Translational Sciences Institute (CCTSI) to target investments in community-based translational research on health disparities is a Community Engagement (CE) Pilot Grants program. Innovative in design, the program accepts proposals from either community or academic applicants, requires that at least half of requested grant funds go to the community partner, and offers two funding tracks: One to develop new community-academic partnerships (up to $10,000), the other to strengthen existing partnerships through community translational research projects (up to $30,000). We have seen early success in both traditional and capacity building metrics: the initial investment of $272,742 in our first cycle led to over $2.8 million dollars in additional grant funding, with grantees reporting strengthening capacity of their community- academic partnerships and the rigor and relevance of their research.

Highly cited articles in wind tunnel-related research: a bibliometric analysis.

PubMed

Mo, Ziwei; Fu, Hui-Zhen; Ho, Yuh-Shan

2018-06-01

Wind tunnels have been widely employed in aerodynamic research. To characterize the high impact research, a bibliometric analysis was conducted on highly cited articles related to wind tunnel based on the Science Citation Index Expanded (SCI-EXPANDED) database from 1900 to 2014. Articles with at least 100 citations from the Web of Science Core Collection were selected and analyzed in terms of publication years, authors, institutions, countries/territories, journals, Web of Science categories, and citation life cycles. The results show that a total of 77 highly cited articles in 37 journals were published between 1959 and 2008. Journal of Fluid Mechanics published the most of highly cited articles. The USA was the most productive country and most frequent partner of internationally collaboration. The prolific institutions were mainly located in the USA and UK. The authors who were both first author and corresponding author published 88% of the articles. The Y index was also deployed to evaluate the publication characteristics of authors. Moreover, the articles with high citations in both history and the latest year with their citation life cycles were examined to provide insights for high impact research. The highly cited articles were almost earliest wind tunnel experimental data and reports on their own research specialty, and thus attracted high citations. It was revealed that classic works of wind tunnel research was frequently occurred in 1990s but much less in 2000s, probably due to the development of numerical models of computational fluid dynamic (CFD) in recent decades.

Acquisition Review Quarterly. Vol. 3, No. 2, Fall 1996

DTIC Science & Technology

1996-11-02

ACQUISITION Fall 1996 TABLE OF CONTENTS OPINION 79 - "CYCLE TIME" - A MILITARY IMPERATIVE Dr. Walter B. LaBerge Emphasis on "minimum cycle time" and...MILITARY IMPERATIVE AS WELL Dr. Walter B. LaBerge Dean Clubb, President of the Defense Systems of Electronics Group, Texas Instruments, Inc., makes in his...lives of resources to provide a broad range of tech- American personnel involved. Also, today Dr. LaBerge is Visiting Professor, Executive Institute at

Knowledge Based Simulation: An Artificial Intelligence Approach to System Modeling and Automating the Simulation Life Cycle.

DTIC Science & Technology

1988-04-13

Simulation: An Artificial Intelligence Approach to System Modeling and Automating the Simulation Life Cycle Mark S. Fox, Nizwer Husain, Malcolm...McRoberts and Y.V.Reddy CMU-RI-TR-88-5 Intelligent Systems Laboratory The Robotics Institute Carnegie Mellon University Pittsburgh, Pennsylvania D T T 13...years of research in the application of Artificial Intelligence to Simulation. Our focus has been in two areas: the use of Al knowledge representation

A Scientific Synthesis and Assessment of the Arctic Carbon Cycle

NASA Astrophysics Data System (ADS)

Hayes, Daniel J.; Guo, Laodong; McGuire, A. David

2007-06-01

The Arctic Monitoring and Assessment Programme (AMAP), along with the Climate and Cryosphere (CliC) Project and the International Arctic Science Committee (IASC), sponsored the Arctic Carbon Cycle Assessment Workshop, at the Red Lion Hotel in Seattle, Wash., between 27 February and 1 March 2007. The workshop was held in a general effort toward the scientific synthesis and assessment of the Arctic system carbon cycle, as well as to generate feedback on the working draft of an assessment document. The initial assessment was prepared by the Arctic carbon cycle assessment writing team, which is led by A. David McGuire (University of Alaska Fairbanks) and includes Leif Anderson (Goteborg University, Sweden), Torben Christensen (Lund University, Sweden), Scott Dallimore (Natural Resources Canada), Laodong Guo (University of Southern Mississippi), Martin Heimann (Max Planck Institute, Germany), Robie MacDonald (Department of Fisheries and Oceans, Canada), and Nigel Roulet (McGill University, Canada). The workshop brought together leading researchers in the fields of terrestrial, marine, and atmospheric science to report on and discuss the current state of knowledge on contemporary carbon stocks and fluxes in the Artie and their potential responses to a changing climate. The workshop was attended by 35 scientists representing institutions from 10 countries in addition to two representatives of the sponsor agencies (John Calder for AMAP and Diane Verseghy for CliC).

76 FR 75553 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel, Diabetes, Endocrinology, and Metabolism... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.847, Diabetes, Endocrinology and...

Enhancing the performance of gastrointestinal tumour board by improving documentation.

PubMed

Alsuhaibani, Roaa Saleh; Alzahrani, Hajer; Algwaiz, Ghada; Alfarhan, Haneen; Alolayan, Ashwaq; Abdelhafiz, Nafisa; Ali, Yosra; Jazieh, Abdul Rahman

2018-01-01

Tumour board contributes to providing better patient care by using a multidisciplinary team approach. In the efforts of evaluating the performance of the gastrointestinal tumour board at our institution, it was difficult to assess past performance due to lack of proper use of standardised documentation tool. This project aimed at improving adherence to the documentation tool and its recommendations in order to obtain performance measures for the tumour board. A multidisciplinary team and a plan were developed to improve documentation. Four rapid improvement cycles, Plan-Do-Study-Act (PDSA) cycles, were conducted. The first cycle focused on updating the case discussion summary form (CDSF) based on experts' input and previous identified deficiencies to enhance documentation and improve performance. The second PDSA cycle aimed at incorporating the CDSF into the electronic medical records system and assessing its functionality. The third cycle was to orient and train staff on using the form and launching it. The fourth PDSA cycle aimed at assessing the ability to obtain tumour board performance measures. Adherence to completion of the CDSF improved from 82% (baseline) to 94% after the fourth PDSA cycle. Over 104 consecutive cases discussed in the tumour board between January and July 2016 and 76 cases discussed in 2015, results were as follows: adherence to National Comprehensive Cancer Network guidelines in 2016 was observed in 141 (95%) recommendations, while it was observed in 90 (92%) recommendations in 2015. Changes in the management plans were observed in 37 (36%) cases in 2016 and in 6 (8%) cases in 2015. Regarding tumour board recommendations, 87% were done within 3 months of tumour board discussion in 2016, while 69% were done in 2015. Implementing electronic standardised documentation tool improved communication among the team and enabled getting accurate data about performance measures of the tumour board with positive impact on healthcare process and outcomes.

Enhancing the performance of gastrointestinal tumour board by improving documentation

PubMed Central

Alsuhaibani, Roaa Saleh; Alzahrani, Hajer; Algwaiz, Ghada; Alfarhan, Haneen; Alolayan, Ashwaq; Abdelhafiz, Nafisa; Ali, Yosra; Jazieh, Abdul Rahman

2018-01-01

Tumour board contributes to providing better patient care by using a multidisciplinary team approach. In the efforts of evaluating the performance of the gastrointestinal tumour board at our institution, it was difficult to assess past performance due to lack of proper use of standardised documentation tool. This project aimed at improving adherence to the documentation tool and its recommendations in order to obtain performance measures for the tumour board. A multidisciplinary team and a plan were developed to improve documentation. Four rapid improvement cycles, Plan–Do–Study–Act (PDSA) cycles, were conducted. The first cycle focused on updating the case discussion summary form (CDSF) based on experts’ input and previous identified deficiencies to enhance documentation and improve performance. The second PDSA cycle aimed at incorporating the CDSF into the electronic medical records system and assessing its functionality. The third cycle was to orient and train staff on using the form and launching it. The fourth PDSA cycle aimed at assessing the ability to obtain tumour board performance measures. Adherence to completion of the CDSF improved from 82% (baseline) to 94% after the fourth PDSA cycle. Over 104 consecutive cases discussed in the tumour board between January and July 2016 and 76 cases discussed in 2015, results were as follows: adherence to National Comprehensive Cancer Network guidelines in 2016 was observed in 141 (95%) recommendations, while it was observed in 90 (92%) recommendations in 2015. Changes in the management plans were observed in 37 (36%) cases in 2016 and in 6 (8%) cases in 2015. Regarding tumour board recommendations, 87% were done within 3 months of tumour board discussion in 2016, while 69% were done in 2015. Implementing electronic standardised documentation tool improved communication among the team and enabled getting accurate data about performance measures of the tumour board with positive impact on healthcare process and outcomes. PMID:29610771

Implementing and Sustaining Data Lifecycle best Practices: a Framework for Researchers and Repositories

NASA Astrophysics Data System (ADS)

Stall, S.

2016-02-01

Emerging data management mandates in conjunction with cross-domain international interoperability are posing new challenges for researchers and repositories. Domain repositories are serving in this critical, growing role monitoring and leading data management standards and capability within their own repository and working on mappings between repositories internationally. Leading research institutions and companies will also be important as they develop and expand data curation efforts. This landscape poses a number of challenges for developing and ensuring the use of best practices in curating research data, enabling discovery, elevating quality across diverse repositories, and helping researchers collect and organize it through the full data life cycle. This multidimensional challenge will continue to grow in complexity. The American Geophysical Union (AGU) is developing two programs to help researchers and data repositories develop and elevate best practices and address these challenges. The goal is to provide tools for the researchers and repositories, whether domain, institutional, or other, that improve performance throughout the data lifecycle across the Earth and space science community. For scientists and researchers, AGU is developing courses around handling data that can lead toward a certification in geoscience data management. Course materials will cover metadata management and collection, data analysis, integration of data, and data presentation. The course topics are being finalized by the advisory board with the first one planned to be available later this year. AGU is also developing a program aimed at helping data repositories, large and small, domain-specific to general, assess and improve data management practices. AGU has partnered with the CMMI® Institute to adapt their Data Management Maturity (DMM)SM framework within the Earth and space sciences. A data management assessment using the DMMSM involves identifying accomplishments and weaknesses compared to leading practices for data management. Recommendations can help improve quality and consistency across the community that will facilitate reuse in the data lifecycle. Through governance, quality, and architecture process areas the assessment can measure the ability for data to be discoverable and interoperable.

Information Product Development: Data product life cycle links engineering, science, and applications

NASA Astrophysics Data System (ADS)

Stavros, E. N.; Owen, S. E.

2016-12-01

Information products are assimilated and used to: a) conduct scientific research and b) provide decision support for management and policy. For example, aboveground biomass (i.e. an information product) can be integrated into Earth system models to test hypotheses about the changing world, or used to inform decision-making with respect to natural resource management and policy. Production and dissemination of an information product is referred to as the data product life cycle, which includes: 1) identifying needed information from decision-makers and researchers, 2) engineering an instrument and collecting the raw physical measurements (e.g, number of photons returned), 3) the scientific algorithm(s) for processing the data into an observable (e.g., number of dying trees), and 4) the integration and utilization of that observables by researchers and decision-makers. In this talk, I will discuss the data product life cycle in detail and provide examples from the pre-Hyperspectral Infrared Imager (HyspIRI) airborne campaign and the upcoming NASA-ISRO Synthetic Aperture Radar (NISAR) mission. Examples will focus on information products related to terrestrial ecosystems and natural resource management and will demonstrate that the key to providing information products for advancing scientific understanding and informing decision-makers, is the interdisciplinary integration of science, engineering and applied science - noting that applied science defines the wider impact and adoption of scientific principles by a wider community. As pre-HyspIRI airborne data is for research and development and NISAR is not yet launched, examples will include current plans for developing exemplar data products (from pre-HyspIRI) and the mission Applications Plan (for NISAR). Copyright 2016 California Institute of Technology. All Rights Reserved. We acknowledge support of the US Government, NASA, the Earth Science Division and Terrestrial Ecology program.

Building capacity in health facility management: guiding principles for skills transfer in Liberia.

PubMed

Rowe, Laura A; Brillant, Sister Barbara; Cleveland, Emily; Dahn, Bernice T; Ramanadhan, Shoba; Podesta, Mae; Bradley, Elizabeth H

2010-03-18

Management training is fundamental to developing human resources for health. Particularly as Liberia revives its health delivery system, facility and county health team managers are central to progress. Nevertheless, such management skills are rarely prioritized in health training, and sustained capacity building in this area is limited. We describe a health management delivery program in which a north and south institution collaborated to integrate classroom and field-based training in health management and to transfer the capacity for sustained management development in Liberia. We developed and implemented a 6-month training program in health management skills (i.e. strategic problem solving, financial management, human resource management and leadership) delivered by Yale University and Mother Patern College from Liberia, with support from the Clinton HIV/AIDS Initiative. Over three 6-month cycles, responsibility for course instruction was transferred from the north institution to the south institution. A self-administered survey was conducted of all participants completing the course to measure changes in self-rated management skills, the degree to which the course was helpful and met its stated objectives, and faculty members' responsiveness to participant needs as the transfer process occurred. Respondents (n=93, response rate 95.9%) reported substantial improvement in self-reported management skills, and rated the helpfulness of the course and the degree to which the course met its objectives highly. Levels of improvement and course ratings were similar over the three cohorts as the course was transferred to the south institution. We suggest a framework of five elements for implementing successful management training programs that can be transferred and sustained in resource-limited settings, including: 1) use a short-course format focusing on four key skill areas with practical tools; 2) include didactic training, on-site projects, and on-site mentoring; 3) collaborate with an in-country academic institution, willing and able to scale-up and maintain the training; 4) provide training for the in-country academic faculty; and 5) secure Ministry-level support to ensure participation. Our findings demonstrate key elements for scaling up and replicating educational initiatives that address management skills essential for long-term health systems strengthening in resource-poor settings.

Including information technology project management in the nursing informatics curriculum.

PubMed

Sockolow, Paulina; Bowles, Kathryn H

2008-01-01

Project management is a critical skill for nurse informaticists who are in prominent roles developing and implementing clinical information systems. It should be included in the nursing informatics curriculum, as evidenced by its inclusion in informatics competencies and surveys of important skills for informaticists. The University of Pennsylvania School of Nursing includes project management in two of the four courses in the master's level informatics minor. Course content includes the phases of the project management process; the iterative unified process methodology; and related systems analysis and project management skills. During the introductory course, students learn about the project plan, requirements development, project feasibility, and executive summary documents. In the capstone course, students apply the system development life cycle and project management skills during precepted informatics projects. During this in situ experience, students learn, the preceptors benefit, and the institution better prepares its students for the real world.

Talent identification and promotion programmes of Olympic athletes.

PubMed

Vaeyens, Roel; Güllich, Arne; Warr, Chelsea R; Philippaerts, Renaat

2009-11-01

The start of a new Olympic cycle offers a fresh chance for individuals and nations to excel at the highest level in sport. Most countries attempt to develop systematic structures to identify gifted athletes and to promote their development in a certain sport. However, forecasting years in advance the next generation of sporting experts and stimulating their development remains problematic. In this article, we discuss issues related to the identification and preparation of Olympic athletes. We provide field-based data suggesting that an earlier onset and a higher volume of discipline-specific training and competition, and an extended involvement in institutional talent promotion programmes, during adolescence need not necessarily be associated with greater success in senior international elite sport. Next, we consider some of the promising methods that have been (recently) presented in the literature and applied in the field. Finally, implications for talent identification and promotion and directions for future research are highlighted.

Population dynamics and rural poverty.

PubMed

Fong, M S

1985-01-01

An overview of the relationship between demographic factors and rural poverty in developing countries is presented. The author examines both the micro- and macro-level perspectives of this relationship and the determinants and consequences of population growth. The author notes the prospects for a rapid increase in the rural labor force and considers its implications for the agricultural production structure and the need for institutional change. Consideration is also given to the continuing demand for high fertility at the family level and the role of infant and child mortality in the poverty cycle. "The paper concludes by drawing attention to the need for developing the mechanism for reconciliation of social and individual optima with respect to family size and population growth." The need for rural development projects that take demographic factors into account is stressed as is the need for effective population programs. (summary in FRE, ITA) excerpt

CSP cogeneration of electricity and desalinated water at the Pentakomo field facility

NASA Astrophysics Data System (ADS)

Papanicolas, C. N.; Bonanos, A. M.; Georgiou, M. C.; Guillen, E.; Jarraud, N.; Marakkos, C.; Montenon, A.; Stiliaris, E.; Tsioli, E.; Tzamtzis, G.; Votyakov, E. V.

2016-05-01

The Cyprus Institute's Pentakomo Field Facility (PFF) is a major infrastructure for research, development and testing of technologies relating to concentrated solar power (CSP) and solar seawater desalination. It is located at the south coast of Cyprus near the sea and its environmental conditions are fully monitored. It provides a test facility specializing in the development of CSP systems suitable for island and coastal environments with particular emphasis on small units (<25 MWth) endowed with substantial storage, suitable for use in isolation or distributed in small power grids. The first major experiment to take place at the PFF concerns the development of a pilot/experimental facility for the co-generation of electricity and desalinated seawater from CSP. Specifically, the experimental plant consists of a heliostat-central receiver system for solar harvesting, thermal energy storage in molten salts followed by a Rankine cycle for electricity production and a multiple-effect distillation (MED) unit for desalination.

Electrochemical characteristics of needle coke refined by molten caustic leaching as an anode material for a lithium-ion battery

NASA Astrophysics Data System (ADS)

Kang, Hyeong-Gon; Park, Jong-Kwang; Han, Byoung-Sung; Lee, Haeseong

Needle coke, the remaining material after refining petroleum, is used as an anode of a lithium-ion secondary battery. Sulfur is separated from the needle coke to below 0.1 wt.% using the molten caustic leaching (MCL) method developed at the Korea Institute of Energy Research. The needle coke with high-purity is carbonized at various temperatures, namely 0, 500, 700 and 900 °C. The coke treated at 700 °C gives a first and second discharge capacity of more than 560 and 460 mAh g -1, respectively, between 0 and 2.0 V. By contrast, the first and second discharge capacity of untreated coke is over 420 and 340 mAh g -1, respectively, between 0.05 and 2.0 V.The first discharge capacity of 560 mAh g -1 is beyond the theoretical maximum capacity of 372 mAh g -1 for LiC 6. Though the cycle efficiency is not consistent, the needle coke heat-treated at 700 °C persistently maintains an efficiency of over 90% until the 50th cycle, except on the first cycle. This study demonstrates that the needle coke with high-purity could be a good candidate for an anode material in fabricating high-capacity lithium-ion secondary batteries.

Intermittent androgen suppression in the LuCaP 23.12 prostate cancer xenograft model.

PubMed

Buhler, K R; Santucci, R A; Royai, R A; Whitney, S C; Vessella, R L; Lange, P H; Ellis, W J

2000-04-01

Intermittent androgen suppression (IAS) has been proposed as a method of delaying the onset of androgen-independent growth in prostate cancer. While several pilot studies have demonstrated the feasibility of such a treatment, no study to date has defined the effect of IAS on survival. We developed an IAS protocol for mice bearing the LuCaP 23.12 human prostate cancer xenograft, with each cycle consisting of 1 week of androgen replacement with a testosterone pellet followed by 3 weeks of androgen withdrawal. Mice that responded to castration with a 40% or greater decrease in serum prostate-specific antigen (PSA) were randomized to treatment with either continuous androgen suppression (CAS) or IAS. Serum PSA, tumor volume, and overall survival were monitored. A total of 75 mice met the randomization criteria. There was no significant difference of survival between animals treated with CAS or IAS (185 vs. 239 days, P = 0.1835). Serum PSA showed evidence of cycling with hormonal manipulation. No cycling was noted in tumor volume. IAS is not associated with a decrease in survival compared to CAS, yet in patients may offer quality-of-life improvements. Further studies of IAS in the setting of Institutional Review Board (IRB) approved clinical trials should be encouraged. Prostate 43:63-70, 2000. Published 2000 Wiley-Liss, Inc.

Climate change impact on growing degree day accumulation values

NASA Astrophysics Data System (ADS)

Bekere, Liga; Sile, Tija; Bethers, Uldis; Sennikovs, Juris

2015-04-01

A well-known and often used method to assess and forecast plant growth cycle is the growing degree day (GDD) method with different formulas used for accumulation calculations. With this method the only factor that affects plant development is temperature. So with climate change and therefore also change in temperature the typical times of plant blooming or harvest can be expected to change. The goal of this study is to assess this change in the Northern Europe region. As an example strawberry bloom and harvest times are used. As the first part of this study it was required to define the current GDD amounts required for strawberry bloom and harvest. It was done using temperature data from the Danish Meteorological Institute's (DMI) NWP model HIRLAM for the years 2010-2012 and general strawberry growth observations in Latvia. This way we acquired an example amount of GDD required for strawberry blooming and harvest. To assess change in the plant growth cycle we used regional climate models (RCM) - Euro-CORDEX. RCM temperature data for both past and future periods was analyzed and bias correction was carried out. Then the GDD calculation methodology was applied on corrected temperature data and results showing change in strawberry growth cycle - bloom and harvest times - in Northern Europe were visualized.

A demand-centered, hybrid life-cycle methodology for city-scale greenhouse gas inventories.

PubMed

Ramaswami, Anu; Hillman, Tim; Janson, Bruce; Reiner, Mark; Thomas, Gregg

2008-09-01

Greenhouse gas (GHG) accounting for individual cities is confounded by spatial scale and boundary effects that impact the allocation of regional material and energy flows. This paper develops a demand-centered, hybrid life-cycle-based methodology for conducting city-scale GHG inventories that incorporates (1) spatial allocation of surface and airline travel across colocated cities in larger metropolitan regions, and, (2) life-cycle assessment (LCA) to quantify the embodied energy of key urban materials--food, water, fuel, and concrete. The hybrid methodology enables cities to separately report the GHG impact associated with direct end-use of energy by cities (consistent with EPA and IPCC methods), as well as the impact of extra-boundary activities such as air travel and production of key urban materials (consistent with Scope 3 protocols recommended by the World Resources Institute). Application of this hybrid methodology to Denver, Colorado, yielded a more holistic GHG inventory that approaches a GHG footprint computation, with consistency of inclusions across spatial scale as well as convergence of city-scale per capita GHG emissions (approximately 25 mt CO2e/person/year) with state and national data. The method is shown to have significant policy impacts, and also demonstrates the utility of benchmarks in understanding energy use in various city sectors.

Effects of 13 T Static Magnetic Fields (SMF) in the Cell Cycle Distribution and Cell Viability in Immortalized Hamster Cells and Human Primary Fibroblasts Cells

NASA Astrophysics Data System (ADS)

Zhao, Guoping; Chen, Shaopeng; Zhao, Ye; Zhu, Lingyan; Huang, Pei; Bao, Lingzhi; Wang, Jun; Wang, Lei; Wu, Lijun; Wu, Yuejin; Xu, An

2010-02-01

Magnetic resonance image (MRI) systems with a much higher magnetic flux density were developed and applied for potential use in medical diagnostic. Recently, much attention has been paid to the biological effects of static, strong magnetic fields (SMF). With the 13 T SMF facility in the Institute of Plasma Physics, Chinese Academy of Sciences, the present study focused on the cellular effects of the SMF with 13 T on the cell viability and the cell cycle distribution in immortalized hamster cells, such as human-hamster hybrid (AL) cells, Chinese hamster ovary (CHO) cells, DNA double-strand break repair deficient mutant (XRS-5) cells, and human primary skin fibroblasts (AG1522) cells. It was found that the exposure of 13 T SMF had less effect on the colony formation in either nonsynchronized or synchronized AL cells. Moreover, as compared to non-exposed groups, there were slight differences in the cell cycle distribution no matter in either synchronized or nonsynchronized immortalized hamster cells after exposure to 13 T SMF. However, it should be noted that the percentage of exposed AG1522 cells at G0/G1 phase was decreased by 10% as compared to the controls. Our data indicated that although 13 T SMF had minimal effects in immortalized hamster cells, the cell cycle distribution was slightly modified by SMF in human primary fibroblasts.

What does it mean to transform knowledge into action in falls prevention research? Perspectives from the Canadian Institutes of Health Research.

PubMed

Tetroe, Jacqueline M; Graham, Ian D; Scott, Vicky

2011-12-01

The concept of knowledge translation as defined by the Canadian Institutes for Health Research and the Knowledge to Action Cycle, described by Graham et al (Graham et al., 2006), are used to make a case for the importance of using a conceptual model to describe moving knowledge into action in the area of falls prevention. There is a large body of research in the area of falls prevention. It would seem that in many areas it is clear what is needed to prevent falls and further syntheses can determine where the evidence is sufficiently robust to warrant its implementation as well as where the gaps are that require further basic research. The phases of the action cycle highlight seven areas that should be paid attention to in order to maximize chances of successful implementation. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

The Role of Scientific Collections in Scientific Preparedness

PubMed Central

2015-01-01

Building on the findings and recommendations of the Interagency Working Group on Scientific Collections, Scientific Collections International (SciColl) aims to improve the rapid access to science collections across disciplines within the federal government and globally, between government agencies and private research institutions. SciColl offered a novel opportunity for the US Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, to explore the value of scientific research collections under the science preparedness initiative and integrate it as a research resource at each stage in the emergence of the infectious diseases cycle. Under the leadership of SciColl’s executive secretariat at the Smithsonian Institution, and with multiple federal and international partners, a workshop during October 2014 fully explored the intersections of the infectious disease cycle and the role scientific collections could play as an evidentiary scientific resource to mitigate risks associated with emerging infectious diseases. PMID:26380390

[Third preparatory committee for the International Conference on Population and Development. Peru presentation].

PubMed

Lopez, C

1994-01-01

This address by the Peruvian delegation to the Third Preparatory Committee Meeting for the International Conference on Population and Development focuses on four points in the proposed Plan of Action that might require further development. First, the link between drug trafficking and environmental degradation should be recognized. Cultivation of narcotic plants contributes to deforestation of the tropical forest and contamination of rivers, and along with terrorism has caused considerable population movement in Peru. The second point is that widespread poverty, limited investment in human capital, insufficient institutional capacity, and the external debt burden of the developing countries are clearly interrelated with sociodemographic processes and decisively affect the capacity of the nation to implement population policies and programs as a function of current and future international commitments. The third point is that, in the area of information, education, and communication, attention should be given to the entire life cycle and the entirety of themes related to population. Finally, coordinated programs between public and private institutions and nongovernmental organizations at the national level, and between the U.N. Population Fund, the Population Commission, and the Commission on Sustainable Development at the international level, should be organized to assure effective follow-up on Plan of Action proposals and agreements. Peru has participated in a wide variety of international conferences and activities related to population, and was a major participant in the subregional preparatory conference of the Andean nations.

Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development.

PubMed

Kinter, Lewis B; DeGeorge, Joseph J

2016-12-01

Human discovery of pharmacologically active substances is arguably the oldest of the biomedical sciences with origins >3500 years ago. Since ancient times, four major transformations have dramatically impacted pharmaceutical development, each driven by advances in scientific knowledge, technology, and/or regulation: (1) anesthesia, analgesia, and antisepsis; (2) medicinal chemistry; (3) regulatory toxicology; and (4) targeted drug discovery. Animal experimentation in pharmaceutical development is a modern phenomenon dating from the 20th century and enabling several of the four transformations. While each transformation resulted in more effective and/or safer pharmaceuticals, overall attrition, cycle time, cost, numbers of animals used, and low probability of success for new products remain concerns, and pharmaceutical development remains a very high risk business proposition. In this manuscript we review pharmaceutical development since ancient times, describe its coevolution with animal experimentation, and attempt to predict the characteristics of future transformations. © The Author 2016. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Antimicrobial Stewardship Program Using Plan-Do-Study-Act Cycles to Reduce Unjustified Antibiotic Prescribing in Children Admitted With an Asthma Exacerbation

PubMed Central

Dorzin, Sasha E.; Halaby, Claudia; Quintos, Maria Lyn; Noor, Asif

2017-01-01

OBJECTIVE Antimicrobial stewardship programs (ASPs) ensure appropriate antibiotic use, reduce health care costs, and minimize antibiotic resistance. National asthma guidelines do not recommend antibiotics during an exacerbation unless the child has an infection or comorbidities. The American Academy of Pediatrics (AAP) established a benchmark for unjustified antibiotic use at 6.6%.9 A retrospective study at our institution showed that 7.8% of antibiotics were prescribed without justification in children admitted for asthma. The purpose of this study was to reduce unjustified antibiotic use at our institution by 25% in children through an ASP directed toward asthma. METHODS The study period lasted from November 2015 to March 2016. Children 6 months to 17 years of age, admitted for an asthma exacerbation, were included while those with comorbidities were excluded. A multidisciplinary team from pediatric pharmacotherapy, pulmonology, emergency department (ED), infectious diseases, and quality improvement was formed to focus on process improvement. Interventions were executed in a series of Plan-Do-Study-Act cycles. In cycle 1, our asthma guidelines on appropriate antibiotic use were disseminated to pediatric house staff and posted in pediatric units. Cycle 2 encompassed presenting the ASP and guidelines to the pediatric ED staff. Cycle 3 consisted of a journal club with the pulmonary division to discuss the role of azithromycin in an asthma exacerbation. RESULTS In cycle 1, twenty-four patients were reviewed in November 2015. Antibiotics were prescribed in 8/24 (33%) children, with an unjustified rate of 2/24 (8.3%). In cycle 2, twenty-three patients were reviewed in December and January with 8/23 (35%) prescribed antibiotics and an unjustified rate of 2/23 (8.7%). For cycle 3, in February and March 2016, twenty-one children were reviewed. Antibiotics were prescribed in 6/21 (27%) children and all were justified. In total, 68 patients were included in our study and had an unjustified antibiotic prescribing rate of 4/68 (5.9%), a reduction of 25%. CONCLUSION Our ASP surpassed the benchmark set by AAP guidelines, by reducing the percentage of unjustified antibiotics in children with asthma to 5.9%. PMID:29290744

Wetlands, Microbes, and the Carbon Cycle: Behind the Scenes @ Berkeley Lab

ScienceCinema

Tringe, Susannah

2018-02-14

Susannah Tringe, who leads the Metagenome Program at the Department of Energy's Joint Genome Institute (JGI), a collaboration in which Berkeley Lab plays a leading role, takes us behind the scenes to show how DNA from unknown wild microbes is extracted and analyzed to see what role they play in the carbon cycle. Tringe collects samples of microbial communities living in the wetland muck of the Sacramento-San Joaquin River Delta, organisms that can determine how these wetlands store or release carbon.

Urbanization and human health in urban India: institutional analysis of water-borne diseases in Ahmedabad.

PubMed

Saravanan, V S; Ayessa Idenal, Marissa; Saiyed, Shahin; Saxena, Deepak; Gerke, Solvay

2016-10-01

Diseases are rapidly urbanizing. Ageing infrastructures, high levels of inequality, poor urban governance, rapidly growing economies and highly dense and mobile populations all create environments rife for water-borne diseases. This article analyzes the role of institutions as crosscutting entities among a myriad of factors that breed water-borne diseases in the city of Ahmedabad, India. It applies 'path dependency' and a 'rational choice' perspective to understand the factors facilitating the breeding of diseases. This study is based on household surveys of approximately 327 households in two case study wards and intermittent interviews with key informants over a period of 2 years. Principle component analysis is applied to reduce the data and convert a set of observations, which potentially correlate with each other, into components. Institutional analyses behind these components reveal the role of social actors in exploiting the deeply rooted inefficiencies affecting urban health. This has led to a vicious cycle; breaking this cycle requires understanding the political dynamics that underlie the exposure and prevalence of diseases to improve urban health. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Lessons Learned from the Deployment and Integration of a Microwave Sounder Based Tropical Cyclone Intensity and Surface Wind Estimation Algorithm into NOAA/NESDIS Satellite Product Operations

NASA Astrophysics Data System (ADS)

Longmore, S. P.; Knaff, J. A.; Schumacher, A.; Dostalek, J.; DeMaria, R.; Chirokova, G.; Demaria, M.; Powell, D. C.; Sigmund, A.; Yu, W.

2014-12-01

The Colorado State University (CSU) Cooperative Institute for Research in the Atmosphere (CIRA) has recently deployed a tropical cyclone (TC) intensity and surface wind radii estimation algorithm that utilizes Suomi National Polar-orbiting Partnership (S-NPP) satellite Advanced Technology Microwave Sounder (ATMS) and Advanced Microwave Sounding Unit (AMSU) from the NOAA18, NOAA19 and METOPA polar orbiting satellites for testing, integration and operations for the Product System Development and Implementation (PSDI) projects at NOAA's National Environmental Satellite, Data, and Information Service (NESDIS). This presentation discusses the evolution of the CIRA NPP/AMSU TC algorithms internally at CIRA and its migration and integration into the NOAA Data Exploitation (NDE) development and testing frameworks. The discussion will focus on 1) the development cycle of internal NPP/AMSU TC algorithms components by scientists and software engineers, 2) the exchange of these components into the NPP/AMSU TC software systems using the subversion version control system and other exchange methods, 3) testing, debugging and integration of the NPP/AMSU TC systems both at CIRA/NESDIS and 4) the update cycle of new releases through continuous integration. Lastly, a discussion of the methods that were effective and those that need revision will be detailed for the next iteration of the NPP/AMSU TC system.

Battery cycling and calendar aging: year one testing results.

DOT National Transportation Integrated Search

2016-07-01

This report is meant to provide an update on the ongoing battery testing performed by the Hawaii Natural Energy Institute to evaluate Electric Vehicle (EV) battery durability and reliability under electric utility grid operations. Commercial EV batte...

The continuity of bacterial and physicochemical evolution: theory and experiments.

PubMed

Spitzer, Jan

2014-01-01

The continuity of chemical and biological evolution, incorporating life's emergence, can be explored experimentally by energizing 'dead' bacterial biomacromolecules with nutrients under cycling physicochemical gradients. This approach arises from three evolutionary principles rooted in physical chemistry: (i) broken bacterial cells cannot spontaneously self-assemble into a living state without the supply of external energy - 2nd law of thermodynamics, (ii) the energy delivery must be cycling - the primary mechanism of chemical evolution at rotating planetary surfaces under solar irradiation, (iii) the cycling energy must act on chemical mixtures of high molecular diversity and crowding - provided by dead bacterial populations. Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Dispersed storage and generation case studies

NASA Technical Reports Server (NTRS)

Bahrami, K.; Stallkamp, J. A.; Walton, A.

1980-01-01

Three installations utilizing separate dispersed storage and generation (DSG) technologies were investigated. Each of the systems is described in costs and control. Selected institutional and environmental issues are discussed, including life cycle costs. No unresolved technical, environmental, or institutional problems were encountered in the installations. The wind and solar photovoltaic DSG were installed for test purposes, and appear to be presently uneconomical. However, a number of factors are decreasing the cost of DSG relative to conventional alternatives, and an increased DSG penetration level may be expected in the future.

Engineering and physical sciences in oncology: challenges and opportunities

PubMed Central

Mitchell, Michael J.; Jain, Rakesh K.; Langer, Robert

2017-01-01

The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas. PMID:29026204

Life cycle assessment: Existing building retrofit versus replacement

NASA Astrophysics Data System (ADS)

Darabi, Nura

The embodied energy in building materials constitutes a large part of the total energy required for any building (Thormark 2001, 429). In working to make buildings more energy efficient this needs to be considered. Integrating considerations about life cycle assessment for buildings and materials is one promising way to reduce the amount of energy consumption being used within the building sector and the environmental impacts associated with that energy. A life cycle assessment (LCA) model can be utilized to help evaluate the embodied energy in building materials in comparison to the buildings operational energy. This thesis takes into consideration the potential life cycle reductions in energy and CO2 emissions that can be made through an energy retrofit of an existing building verses demolition and replacement with a new energy efficient building. A 95,000 square foot institutional building built in the 1960`s was used as a case study for a building LCA, along with a calibrated energy model of the existing building created as part of a previous Masters of Building Science thesis. The chosen case study building was compared to 10 possible improvement options of either energy retrofit or replacement of the existing building with a higher energy performing building in order to see the life cycle relationship between embodied energy, operational energy, and C02 emissions. As a result of completing the LCA, it is shown under which scenarios building retrofit saves more energy over the lifespan of the building than replacement with new construction. It was calculated that energy retrofit of the chosen existing institutional building would reduce the amount of energy and C02 emissions associated with that building over its life span.

Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity.

PubMed

Chowdhary, Mudit; Sen, Neilayan; Jeans, Elizabeth B; Miller, Luke; Batus, Marta; Gitelis, Steven; Wang, Dian; Abrams, Ross A

2018-05-18

Patients with large, high-grade extremity soft tissue sarcoma (STS) are at high risk for both local and distant recurrence. RTOG 95-14, using a regimen of neoadjuvant interdigitated chemoradiotherapy with mesna, doxorubicin, ifosfamide, and dacarbazine followed by surgery and 3 cycles of adjuvant mesna, doxorubicin, ifosfamide, and dacarbazine, demonstrated high rates of disease control at the cost of significant toxicity (83% grade 4, 5% grade 5). As such, this regimen has not been widely adopted. Herein, we report our institutional outcomes utilizing a modified interdigitated chemoradiotherapy regimen, without dacarbazine, and current radiotherapy planning and delivery techniques for high-risk STS. Adults with large (≥5 cm; median, 12.9 cm), grade 3 extremity STS who were prospectively treated as part of our institutional standard of care from 2008 to 2016 are included. Neoadjuvant chemoradiotherapy consisted of 3 cycles of mesna, doxorubicin, and ifosfamide (MAI) and 44 Gy (22 Gy in 11 fractions between cycles of MAI) after which patients underwent surgical resection and received 3 additional cycles of MAI. Twenty-six patients received the MAI treatment protocol. At a median follow-up of 47.3 months, 23 (88.5%) patients are still alive. Three year locoregional recurrence-free survival, disease-free survival, and overall survival are 95.0%, 64.0%, and 95.0%, respectively. There have been no therapy-related deaths or secondary malignancies. The nonhematologic grade 4 toxicity rate was 7.7%. Neoadjuvant interdigitated MAI radiotherapy followed by resection and 3 cycles of adjuvant MAI has resulted in acceptable and manageable toxicity and highly favorable survival in patients at greatest risk for treatment failure.

TIRCAM2: The TIFR near infrared imaging camera

NASA Astrophysics Data System (ADS)

Naik, M. B.; Ojha, D. K.; Ghosh, S. K.; Poojary, S. S.; Jadhav, R. B.; Meshram, G. S.; Sandimani, P. R.; Bhagat, S. B.; D'Costa, S. L. A.; Gharat, S. M.; Bakalkar, C. B.; Ninan, J. P.; Joshi, J. S.

2012-12-01

TIRCAM2 (TIFR near infrared imaging camera - II) is a closed cycle cooled imager that has been developed by the Infrared Astronomy Group at the Tata Institute of Fundamental Research for observations in the near infrared band of 1 to 3.7 μm with existing Indian telescopes. In this paper, we describe some of the technical details of TIRCAM2 and report its observing capabilities, measured performance and limiting magnitudes with the 2-m IUCAA Girawali telescope and the 1.2-m PRL Gurushikhar telescope. The main highlight is the camera's capability of observing in the nbL (3.59 mum) band enabling our primary motivation of mapping of Polycyclic Aromatic Hydrocarbon (PAH) emission at 3.3 mum.

Nibbled to Death by Ducks: The Accumulation of Disadvantage

NASA Astrophysics Data System (ADS)

Simpson, Caroline E.

2010-05-01

One of the consequences of unconscious bias is the accumulation of advantage/disadvantage. Research has shown that over time, minor imbalances will accrue and eventually have major impacts regarding promotion, salary, prestige, and advancement to leadership positions. For example, an unconscious bias during an evaluation leading to an underestimate of performance will result in a lower success rate, which then feeds back into the next evaluation and the cycle repeats. How can we address this? We'll be discussing how to become informed and conscious of the problem, and we'll look at recommendations for developing and implementing departmental and institutional policies and practices aimed at increasing awareness and countering these accumulations of imbalances that impact us all.

Natural Gas and the Transformation of the U.S. Energy Sector: Electricity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, J.; Heath, G.; Macknick, J.

The Joint Institute for Strategic Energy Analysis (JISEA) designed this study to address four related key questions, which are a subset of the wider dialogue on natural gas: 1. What are the life cycle greenhouse gas (GHG) emissions associated with shale gas compared to conventional natural gas and other fuels used to generate electricity?; 2. What are the existing legal and regulatory frameworks governing unconventional gas development at federal, state, and local levels, and how are they changing in response to the rapid industry growth and public concerns?; 3. How are natural gas production companies changing their water-related practices?; andmore » 4. How might demand for natural gas in the electric sector respond to a variety of policy and technology developments over the next 20 to 40 years?« less

Comparing Life-Cycle Impacts of Solid Waste Management Strategies

EPA Science Inventory

The presentation is for a webinar by the Prodct Stewardship Institute (PSI)which is a national non-profit membership-based organization located in Boston, Massachusetts. PSI works with state and local government agencies to partner with manufacturers, retailers, environmental gr...

Overview of the INPRO Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kupitz, J.; Depisch, F.; Zou, Y.

2004-10-03

During the last fifty years remarkable results are achieved in the application of nuclear technology for the production of electricity. Looking ahead to the next fifty years it is clear that the demand for energy will grow considerably and also the requirements for the way the energy will be supplied. Within the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), the future of the energy demand and supply was explored and several scenario's identified. A leading requirement for energy supply is coming up and will play a crucial role: sustainability of the way the energy supply will bemore » realized. Fulfilling the growing need for energy in developing countries is as well an important issue. Based on these scenario's for the next fifty years, an inventory of requirements for the future of nuclear energy systems has been collected as well a methodology developed by INPRO to assess innovative nuclear systems and fuel cycles. On the base of this assessment, the need for innovations and breakthroughs in existing technology can be defined. To facilitate the deployment of innovative nuclear systems also the infrastructure, technical as well as institutional has to be adjusted to the anticipated changes in the world such as the globalization. As a contribution to the conference the main messages of INPRO will be presented.« less

A Water and Energy Community of Practice (WECoP)

NASA Astrophysics Data System (ADS)

Houser, P. R.

2008-12-01

Earth is a unique, living planet due to the abundance and vigorous cycling and replenishing of water throughout the global environment. The water cycle operates on a continuum of time and space scales and exchanges large amounts of energy as water undergoes phase changes and is moved from one part of the Earth system to another. Water is essential to life and is central to society's welfare, progress, and sustainable economic growth. However, global water cycle variability which regulates flood, drought, and disease hazards is being continuously transformed by climate change, erosion, pollution, salinization, and agriculture and civil engineering practices. The most visible manifestation that could be expected from climate warming would be changes in the distribution of precipitation and evaporation, and the exacerbation of extreme hydrologic events, floods and droughts. Technological advances, climate modeling and forecasting improvements and the emergence of earth system science will enable development of solutions for these daunting global water problems, and much of the needed scientific information is already available. A plethora of institutional, policy, management and communication problems have been neglected, which has resulted in significant underutilization of existing scientific information for solving contemporary and anticipated water issues. Effective communication and outreach is the critical task to enable existing science to be used to its full potential, to develop comprehensive solution strategies and to set future research priorities. The missing link is a water-focused Community of Practice (CoP) who has knowledge of both the decision support needs and the cutting-edge research results, and therefore can formulate a broad array of solutions to water problems today and into the future. The concept of a community of practice refers to the process of social learning that occurs when people who have a common interest in some subject or problem collaborate over an extended period to share ideas, find solutions, and build innovations. It refers as well to the stable group that is formed from such regular interactions. A CoP consists of three elements; developing these elements will cultivate the CoP: (1) A shared domain of interest - in this case water, (2) CoP members communicate, share information, engage in joint activities and learn from each other, and (3) Members of the CoP are engaged in a shared practice - developing a shared repertoire of resources, experiences, stories, case studies and tools. The NASA water-cycle solutions network project (WaterNet) mission is to improve our collective ability to routinely interact with and harness the results of scientific research so as to address water assessment, prediction and management challenges. This presentation will detail how WaterNet activities are helping to foster and enable a Water and Energy cycle CoP (WECoP), and how partnerships are cultivating an international Water Cycle Community of Practice, as follows: (1) Demonstration project and case studies. (2) Development of a web-based information portal, for sharing ideas and information. (3) Development of a knowledge base and water information search utility. (4) Fostering partnerships amon: CUAHSI, ESIP, NIDIS, GEOSS, GEWEX, NEWS, NCAR, etc. (5) Developing a newsletters and information guides. (6) Education and outreach activities. (7) Developing community-wide user needs, research capabilities and gap assessments. (8) Development of data integration capabilities. (9) Development of rapid-prototyping, test-bed and benchmarking capabilities. (10) Development and sharing of data, model and decision tool assets.

A factor analysis approach to examining relationships among ovarian steroid concentrations, gonadotrophin concentrations and menstrual cycle length characteristics in healthy, cycling women

PubMed Central

Barrett, E.S.; Thune, I.; Lipson, S.F.; Furberg, A.-S.; Ellison, P.T.

2013-01-01

STUDY QUESTION How are ovarian steroid concentrations, gonadotrophins and menstrual cycle characteristics inter-related within normal menstrual cycles? SUMMARY ANSWER Within cycles, measures of estradiol production are highly related to one another, as are measures of progesterone production; however, the two hormones also show some independence from one another, and measures of cycle length and gonadotrophin concentrations show even greater independence, indicating minimal integration within cycles. WHAT IS KNOWN ALREADY The menstrual cycle is typically conceptualized as a cohesive unit, with hormone levels, follicular development and ovulation all closely inter-related within a single cycle. Empirical support for this idea is limited, however, and to our knowledge, no analysis has examined the relationships among all of these components simultaneously. STUDY DESIGN, SIZE, DURATION A total of 206 healthy, cycling Norwegian women participated in a prospective cohort study (EBBA-I) over the duration of a single menstrual cycle. Of these, 192 contributed hormonal and cycle data to the current analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS Subjects provided daily saliva samples throughout the menstrual cycle from which estradiol and progesterone concentrations were measured. FSH and LH concentrations were measured in serum samples from three points in the same menstrual cycle and cycle length characteristics were calculated based on hormonal data and menstrual records. A factor analysis was conducted to examine the underlying relationships among 22 variables derived from the hormonal data and menstrual cycle characteristics. MAIN RESULTS AND THE ROLE OF CHANCE Six rotated factors emerged, explaining 80% of the variance in the data. Of these, factors representing estradiol and progesterone concentrations accounted for 37 and 13% of the variance, respectively. There was some association between measures of estradiol and progesterone production within cycles; however, cycle length characteristics and gonadotrophin concentrations showed little association with any measure of ovarian hormone concentrations. LIMITATIONS, REASONS FOR CAUTION Our summary measures of ovarian hormones may be imprecise in women with extremely long or short cycles, which could affect the patterns emerging in the factor analysis. Given that we only had data from one cycle on each woman, we cannot address how cycle characteristics may covary within individual women across multiple cycles. WIDER IMPLICATIONS OF THE FINDINGS Our findings are generalizable to other healthy populations with typical cycles, however, may not be applicable to cycles that are anovulatory, extreme in length or otherwise atypical. The results support previous findings that measures of estradiol production are highly correlated across the cycle, as are measures of progesterone production. Estradiol and progesterone concentrations are associated with one another, furthermore. However factor analysis also revealed more complex underlying patterns in the menstrual cycle, highlighting the fact that gonadotrophin concentrations and cycle length characteristics are virtually independent of ovarian hormones. These results suggest that despite integration of follicular and luteal ovarian steroid production across the cycle, cycle quality is a multi-faceted construct, rather than a single dimension. STUDY FUNDING/COMPETING INTEREST(S) The EBBA-I study was supported by a grant from the Norwegian Cancer Society (49 258, 05087); Foundation for the Norwegian Health and Rehabilitation Organizations (59010-2000/2001/2002); Aakre Foundation (5695-2000, 5754-2002) and Health Region East. The current analyses were completed under funding from the National Institutes of Health (K12 ES019852). No competing interests declared. PMID:23250924

Bortezomib-Containing Regimens for the Treatment of Newly Diagnosed and Relapsed Amyloid Light Chain Amyloidosis: A Single-Center Experience.

PubMed

Jimenez-Zepeda, Victor H; Duggan, Peter; Neri, Paola; Bahlis, Nizar J

2016-06-01

The proteasome is an exciting target for the development of novel anticancer therapies. Recent evidence has suggested that bortezomib, a dipeptide boronate proteasome inhibitor, exhibits unprecedented single-agent activity in amyloid light chain (AL) amyloidosis. We performed a retrospective review of the use of bortezomib-containing regimens to assess the rapidity and quality of response at our institution. A total of 52 patients with documented newly diagnosed and relapsed AL amyloidosis treated with bortezomib-containing regimens were identified from our institutional database. After a median of 4 cycles (range, 1-22 cycles), a hematologic response was seen in 49 patients (94.2%), including a complete response in 15 (28.8%), a very good partial response in 25 (48.1%), and a partial response in 9 (17.3%). At 6 weeks, 37 patients had already achieved a partial response. An organ response at 6 months was documented in 31 patients (59.6%). With respect to the cardiac response, a > 30% decrease in N-terminal pro-hormone brain natriuretic peptide (NT-proBNP) was observed in 17 of 35 evaluable patients (48.6%; NT-proBNP > 650 ng/L) at a median of 6 months. Overall survival was shorter for the patients with NT-proBNP > 5000 ng/L and for those who achieved less than a very good partial response. Bortezomib is a safe and well-tolerated therapy for patients with AL amyloidosis with a rapid hematologic response and cardiac response, as assessed by the NT-proBNP level. Copyright © 2016 Elsevier Inc. All rights reserved.

Impact on hepatic estrogen-sensitive proteins by a 1-year contraceptive vaginal ring delivering Nestorone® and ethinyl estradiol.

PubMed

Archer, D F; Thomas, M A; Conard, J; Merkatz, R B; Creasy, G W; Roberts, K; Plagianos, M; Blithe, D; Sitruk-Ware, R

2016-01-01

Estrogen-sensitive hepatic proteins were assessed in women using a contraceptive vaginal ring (CVR) delivering 150mcg Nestorone® (NES) and 15mcg ethinyl estradiol (EE). A substudy of the Contraceptive Clinical Trials Network of the National Institute of Child Health and Human Development enrolled 129 participants, with assessments of factor VIII, fibrinogen, protein S (PS) and sex hormone binding globulin (SHBG). Thirty-six participants had used combined hormonal contraceptives (CHCs) in the cycle preceding first CVR use (recent users) and 70 had no history of recent use (nonusers). Mean values at baseline were within the normal range for all four proteins but were higher for factor VIII, fibrinogen and SHBG and significantly lower for PS in recent compared to nonusers. During NES/EE CVR use, factor VIII, fibrinogen and PS were within the normal range; however, SHBG levels were increased by nearly 100% at Cycle 13. The change from baseline to final evaluation was statistically significant for all proteins in nonusers. The change in recent users was significant for factor VIII at Cycle 6 and for SHBG at Cycles 6 and 13, but not for PS or fibrinogen. NES/EE CVR for up to 13cycles was associated with changes from baseline in plasma levels of factor VIII, fibrinogen and PS that were within the normal range, with SHBG levels above the normal range by Cycle 6. Nonusers of CHC before CVR showed wider changes in values versus recent users whose baseline values were increased by previous EE exposure. Recent use of CHCs demonstrated significant changes in all four measured hepatic proteins at baseline compared to nonusers. Use of the NES/EE CVR further changed these hepatic protein markers, but values remained within the normal range. Prebaseline exposure to estrogen can obscure interpretation of hepatic proteins changes associated with a second CHC. Copyright © 2016 Elsevier Inc. All rights reserved.

Secular pattern of aneurismal rupture with the lunar cycle and season.

PubMed

Banfield, Jillian C; Abdolell, Mohamed; Shankar, Jai S

2017-02-01

Background The lunar cycle and seasons may be associated with rates of rupture of intracranial aneurysms, but the literature is mixed. Studies of the association between the lunar cycle and rates of aneurysm rupture used the eight qualitative moon phases. The purpose of this study was to assess any association of aneurysm rupture with the lunar cycle and with the season. Materials and methods We retrospectively reviewed all cases of subarachnoid haemorrhage secondary to ruptured intracranial aneurysm treated with endovascular coiling in our institution over a 10-year period. We included only cases with a known rupture date. We used the degree of illumination of the moon to quantitatively code the lunar cycle. Results A total of 212 cases were included in our analyses. The odds of aneurysm rupture were significantly greater ( p < 0.001) when the moon was least (new moon) and most (full moon) illuminated, as compared to the middle of the lunar cycle. The odds of rupture tended to be higher ( p = 0.059) in the summer, compared to autumn. Conclusions The odds of aneurysm rupture were greater when the moon was least illuminated (new moon) and most illuminated (full moon), compared to the middle of the lunar cycle.

Analysis of Perioperative Chemotherapy in Resected Pancreatic Cancer: Identifying the Number and Sequence of Chemotherapy Cycles Needed to Optimize Survival.

PubMed

Epelboym, Irene; Zenati, Mazen S; Hamad, Ahmad; Steve, Jennifer; Lee, Kenneth K; Bahary, Nathan; Hogg, Melissa E; Zeh, Herbert J; Zureikat, Amer H

2017-09-01

Receipt of 6 cycles of adjuvant chemotherapy (AC) is standard of care in pancreatic cancer (PC). Neoadjuvant chemotherapy (NAC) is increasingly utilized; however, optimal number of cycles needed alone or in combination with AC remains unknown. We sought to determine the optimal number and sequence of perioperative chemotherapy cycles in PC. Single institutional review of all resected PCs from 2008 to 2015. The impact of cumulative number of chemotherapy cycles received (0, 1-5, and ≥6 cycles) and their sequence (NAC, AC, or NAC + AC) on overall survival was evaluated Cox-proportional hazard modeling, using 6 cycles of AC as reference. A total of 522 patients were analyzed. Based on sample size distribution, four combinations were evaluated: 0 cycles = 12.1%, 1-5 cycles of combined NAC + AC = 29%, 6 cycles of AC = 25%, and ≥6 cycles of combined NAC + AC = 34%, with corresponding survival. 13.1, 18.5, 37, and 36.8 months. On MVA (P < 0.0001), tumor stage [hazard ratio (HR) 1.35], LNR (HR 4.3), and R1 margins (HR 1.77) were associated with increased hazard of death. Compared with 6 cycles AC, receipt of 0 cycles [HR 3.57, confidence interval (CI) 2.47-5.18] or 1-5 cycles in any combination (HR 2.37, CI 1.73-3.23) was associated with increased hazard of death, whereas receipt of ≥6 cycles in any sequence was associated with optimal and comparable survival (HR 1.07, CI 0.78-1.47). Receipt of 6 or more perioperative cycles of chemotherapy either as combined neoadjuvant and adjuvant or adjuvant alone may be associated with optimal and comparable survival in resected PC.

Continuing Education and Training.

ERIC Educational Resources Information Center

Alger, Ian, Ed.

1983-01-01

Reviews two conferences sponsored by the Ackerman Institute for Family Therapy: "Professional Systems and the Family," focusing on the interfaces among family therapists and professionals in education, health care, and human resources, and "Family Systems Over Time: The Fourth Dimension," focusing on the family life cycle, and…

Computing and Office Automation: Changing Variables.

ERIC Educational Resources Information Center

Staman, E. Michael

1981-01-01

Trends in computing and office automation and their applications, including planning, institutional research, and general administrative support in higher education, are discussed. Changing aspects of information processing and an increasingly larger user community are considered. The computing literacy cycle may involve programming, analysis, use…

Solar System Exploration Research Virtual Institute: Year Three Annual Report 2016

NASA Technical Reports Server (NTRS)

Pendleton, Yvonne; Schmidt, Greg; Kring, David; Horanyi, Mihaly; Heldmann, Jennifer; Glotch, Timothy; Rivkin, Andy; Farrell, William; Pieters, Carle; Bottke, William;

SU-F-T-665: Confocal Microscopy Imaging of Cell Cycle Distribution in Cells Treated with Pegylated Gold Nanoshells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sadetaporn, D; The University of Texas MD Anderson Cancer Center, Houston, TX; Flint, D

Purpose: To use confocal microscopy to distinguish cells in different phases of the cell cycle before and after treatment with pegylated gold nanoshells (PEG-AuNSs). Methods: Transfected fibrosarcoma cells (HT1080-EYFP-53BP1-FUCCI) were cultured in T-25 flasks and seeded in glass bottom dishes. These cells express the fluorescent probe AmCyan during the G2/S phases of the cell cycle, mCherry during the G1 phase, and EYFP tagged to the DNA repair protein 53BP1. After allowing cells 4 h to adhere to dishes, PEG-AuNS (Nanospectra Biosciences, Houston, TX) at a concentration of 0.15 OD were administered. At time points of 8, 16 and 24 hmore » following treatment, the PEG-AuNS-treated and control samples were washed with phosphate buffered saline (PBS) and fixed using 4% paraformaldehyde in PBS. Samples were imaged with an Olympus FV1200 confocal microscope using 473, 543, and 641 nm excitation lasers. We used band-pass filters to select AmCyan and mCherry fluorescence. Reflection from the 641 nm laser was used to detect PEG-AuNSs. Z-stack images were analyzed to assess cell cycle distribution through fluorescent probe expression. Live cells were imaged after PEG-AuNS treatment using a confocal microscope with a stage top CO2 incubator. Results: We were able to obtain high-resolution images of cells with internalized AuNSs. We were also able to distinguish cells in different phases of the cell cycle. Conclusion: This work demonstrates a new assay to investigate the effect of AuNSs on the cell cycle phase in live cells. Future work will employ confocal microscopy and flow cytometry to focus on effects of AuNS treatment on cell cycle distribution. This research was supported by the Sister Institution Network Fund and the Center for Radiation Oncology Research at The University of Texas MD Anderson Cancer Center and Cancer Prevention and Research Institute of Texas. Gabriel Sawakuchi has research support from Elekta Inc.« less

Rapporteur report: MHD electric power plants

NASA Technical Reports Server (NTRS)

Seikel, G. R.

1980-01-01

Five US papers from the Proceedings of the Seventh International Conference on MHD Electrical Power Generation at the Massachusetts Institute of Technology are summarized. Results of the initial parametric phase of the US effort on the study of potential early commercial MHD plants are reported and aspects of the smaller commercial prototype plant termed the Engineering Test Facility are discussed. The alternative of using a disk geometry generator rather than a linear generator in baseload MHD plants is examined. Closed-cycle as well as open-cycle MHD plants are considered.

Data Analysis of the NOAA-GIT (National Oceanic and Atmospheric Administration-Georgia Institute of Technology) Millimeter-Wave Propagation Experiment Near Flatville, Illinois.

DTIC Science & Technology

1985-08-01

nearby Lyman-a hygrometer with another wire ther- mometer within its gap, a prop-vane anemometer, and a psychrometer for mean temperature and...0.39-Hz pulse, the psychrometer gives six commutation cycles repeated at the 25-Hz rate. A commutation cycle consists of data from the wet and dry...bulbs and two reference values, four quantities in all. The psychrometer then returns toward thermal equilibrium until the next 0.39-Hz pulse calls for

Development and application of a double-piston configured, total-liquid ventilatory support device.

PubMed

Meinhardt, J P; Quintel, M; Hirschl, R B

2000-05-01

Perfluorocarbon liquid ventilation has been shown to enhance pulmonary mechanics and gas exchange in the setting of respiratory failure. To optimize the total liquid ventilation process, we developed a volume-limited, time-cycled liquid ventilatory support, consisting of an electrically actuated, microprocessor-controlled, double-cylinder, piston pump with two separate limbs for active inspiration and expiration. Prospective, controlled, animal laboratory study, involving sequential application of conventional gas ventilation, partial ventilation (PLV), and total liquid ventilation (TLV). Research facility at a university medical center. A total of 12 normal adult New Zealand rabbits weighing 3.25+/-0.1 kg. Anesthestized rabbits were supported with gas ventilation for 30 mins (respiratory rate, 20 cycles/min; peak inspiratory pressure, 15 cm H2O; end-expiratory pressure, 5 cm H2O), then PLV was established with perflubron (12 mL/kg). After 15 mins, TLV was instituted (tidal volume, 18 mL/kg; respiratory rate, 7 cycles/min; inspiratory/expiratory ratio, 1:2 cycles/min). After 4 hrs of TLV, PLV was re-established. Of 12 animals, nine survived the 4-hr TLV period. During TLV, mean values +/- SEM were as follows: PaO2, 363+/-30 torr; PaCO2, 39+/-1.5 torr; pH, 7.39+/-0.01; static peak inspiratory pressure, 13.2+/-0.2 cm H2O; static endexpiratory pressure, 5.5+/-0.1 cm H2O. No significant changes were observed. When compared with gas ventilation and PLV, significant increases occurred in mean arterial pressure (62.4+/-3.5 torr vs. 74.0+/-1.2 torr) and central venous pressure (5.6+/-0.7 cm H2O vs. 7.8+/-0.2 cm H2O) (p < .05). Total liquid ventilation can be performed successfully utilizing piston pumps with active expiration. Considering the enhanced flow profiles, this device configuration provides advantages over others.

Optimizing the post-graduate institutional program evaluation process.

PubMed

Lypson, Monica L; Prince, Mark E P; Kasten, Steven J; Osborne, Nicholas H; Cohan, Richard H; Kowalenko, Terry; Dougherty, Paul J; Reynolds, R Kevin; Spires, M Catherine; Kozlow, Jeffrey H; Gitlin, Scott D

2016-02-17

Reviewing program educational efforts is an important component of postgraduate medical education program accreditation. The post-graduate review process has evolved over time to include centralized oversight based on accreditation standards. The institutional review process and the impact on participating faculty are topics not well described in the literature. We conducted multiple Plan-Do-Study-Act (PDSA) cycles to identify and implement areas for change to improve productivity in our institutional program review committee. We also conducted one focus group and six in-person interviews with 18 committee members to explore their perspectives on the committee's evolution. One author (MLL) reviewed the transcripts and performed the initial thematic coding with a PhD level research associate and identified and categorized themes. These themes were confirmed by all participating committee members upon review of a detailed summary. Emergent themes were triangulated with the University of Michigan Medical School's Admissions Executive Committee (AEC). We present an overview of adopted new practices to the educational program evaluation process at the University of Michigan Health System that includes standardization of meetings, inclusion of resident members, development of area content experts, solicitation of committed committee members, transition from paper to electronic committee materials, and focus on continuous improvement. Faculty and resident committee members identified multiple improvement areas including the ability to provide high quality reviews of training programs, personal and professional development, and improved feedback from program trainees. A standing committee that utilizes the expertise of a group of committed faculty members and which includes formal resident membership has significant advantages over ad hoc or other organizational structures for program evaluation committees.

The Proposal Auto-Categorizer and Manager for Time Allocation Review at the Space Telescope Science Institute

NASA Astrophysics Data System (ADS)

Strolger, Louis-Gregory; Porter, Sophia; Lagerstrom, Jill; Weissman, Sarah; Reid, I. Neill; Garcia, Michael

2017-04-01

The Proposal Auto-Categorizer and Manager (PACMan) tool was written to respond to concerns about subjective flaws and potential biases in some aspects of the proposal review process for time allocation for the Hubble Space Telescope (HST), and to partially alleviate some of the anticipated additional workload from the James Webb Space Telescope (JWST) proposal review. PACMan is essentially a mixed-method Naive Bayesian spam filtering routine, with multiple pools representing scientific categories, that utilizes the Robinson method for combining token (or word) probabilities. PACMan was trained to make similar programmatic decisions in science category sorting, panelist selection, and proposal-to-panelists assignments to those made by individuals and committees in the Science Policies Group (SPG) at the Space Telescope Science Institute. Based on training from the previous cycle’s proposals, at an average of 87%, PACMan made the same science category assignments for proposals in Cycle 24 as the SPG. Tests for similar science categorizations, based on training using proposals from additional cycles, show that this accuracy can be further improved, to the > 95 % level. This tool will be used to augment or replace key functions in the Time Allocation Committee review processes in future HST and JWST cycles.

RMS: a platform for managing cross-disciplinary and multi-institutional research project collaboration.

PubMed

Luo, Jake; Apperson-Hansen, Carolyn; Pelfrey, Clara M; Zhang, Guo-Qiang

2014-11-30

Cross-institutional cross-disciplinary collaboration has become a trend as researchers move toward building more productive and innovative teams for scientific research. Research collaboration is significantly changing the organizational structure and strategies used in the clinical and translational science domain. However, due to the obstacles of diverse administrative structures, differences in area of expertise, and communication barriers, establishing and managing a cross-institutional research project is still a challenging task. We address these challenges by creating an integrated informatics platform to reduce the barriers to biomedical research collaboration. The Request Management System (RMS) is an informatics infrastructure designed to transform a patchwork of expertise and resources into an integrated support network. The RMS facilitates investigators' initiation of new collaborative projects and supports the management of the collaboration process. In RMS, experts and their knowledge areas are categorized and managed structurally to provide consistent service. A role-based collaborative workflow is tightly integrated with domain experts and services to streamline and monitor the life-cycle of a research project. The RMS has so far tracked over 1,500 investigators with over 4,800 tasks. The research network based on the data collected in RMS illustrated that the investigators' collaborative projects increased close to 3 times from 2009 to 2012. Our experience with RMS indicates that the platform reduces barriers for cross-institutional collaboration of biomedical research projects. Building a new generation of infrastructure to enhance cross-disciplinary and multi-institutional collaboration has become an important yet challenging task. In this paper, we share the experience of developing and utilizing a collaborative project management system. The results of this study demonstrate that a web-based integrated informatics platform can facilitate and increase research interactions among investigators.

The Duke Elder Lecture: The challenge of equitable eye care in Pakistan

PubMed Central

Khan, M D

2011-01-01

Purpose Pakistan, like many other developing countries, is caught in the vicious cycle of poverty, illiteracy, violence, and disease. Right from its inception, it has been facing serious challenges of fast growing population, longevity, unemployment, wars, floods, double burden of diseases including blindness, as well as earthquakes, insurgencies, and political instability. Despite such challenges, the country has managed to reduce the burden of blindness from 1.78% in 1987-88 to 0.9% in 2003.This paper will highlight the methods used to achieve such a difficult goal. Methods The country used the report of the World Health Organization (WHO) temporary consultant as the initial tool for advocacy to obtain political and professional commitment. Results from the first National Blindness Survey 1987–1990 were used as baseline for development of the programme. Under the Ministry of Health, national and provincial committees with respective coordinators were constituted. To ensure access and equity, the national programme was developed on the basis of district comprehensive eye care services. The concept was carefully tested in a laboratory and then piloted in a real district before it was rolled over to the country. Strong national institutes for human resource development, research and development, and service delivery were established. A strong network of high-quality national institutes was set up and run by powerful national non-governmental organizations. The second National Blindness Survey evaluated the achievements of the programme in 2001–2003. Conclusion National prevalence of blindness was reduced by 100% by improving the uptake of services at the district level, especially by females. PMID:21252948

The Duke Elder lecture: the challenge of equitable eye care in Pakistan.

PubMed

Khan, M D

2011-04-01

Pakistan, like many other developing countries, is caught in the vicious cycle of poverty, illiteracy, violence, and disease. Right from its inception, it has been facing serious challenges of fast growing population, longevity, unemployment, wars, floods, double burden of diseases including blindness, as well as earthquakes, insurgencies, and political instability. Despite such challenges, the country has managed to reduce the burden of blindness from 1.78% in 1987-88 to 0.9% in 2003.This paper will highlight the methods used to achieve such a difficult goal. The country used the report of the World Health Organization (WHO) temporary consultant as the initial tool for advocacy to obtain political and professional commitment. Results from the first National Blindness Survey 1987-1990 were used as baseline for development of the programme. Under the Ministry of Health, national and provincial committees with respective coordinators were constituted. To ensure access and equity, the national programme was developed on the basis of district comprehensive eye care services. The concept was carefully tested in a laboratory and then piloted in a real district before it was rolled over to the country. Strong national institutes for human resource development, research and development, and service delivery were established. A strong network of high-quality national institutes was set up and run by powerful national non-governmental organizations. The second National Blindness Survey evaluated the achievements of the programme in 2001-2003. National prevalence of blindness was reduced by 100% by improving the uptake of services at the district level, especially by females.

Application of agrometeorological spectral model in rice area in southern Brazil

NASA Astrophysics Data System (ADS)

Leivas, Janice F.; de C. Teixeira, Antonio Heriberto; Andrade, Ricardo G.; de C. Victoria, Daniel; Bayma-Silva, Gustavo; Bolfe, Edson L.

2015-10-01

The southern region is responsible for 70% of rice production in Brazil. In this study, rice areas of Rio Grande do Sul were selected, using the land use classification, scale 1: 100,000, provided by Brazilian Institute of Geography and Statistics (IBGE). MODIS Images were used and meteorological data, available by National Institute of Meteorology (INMET). The period of analysis was crop season 2011/2012, October to March. To obtain evapotranspiration was applied agrometeorological-spectral model SAFER (Simple Algorithm For Retrieving Evapotranspiration). From the analysis of the results, on planting and cultivation period , the average evapotranspiration (ET) daily was 1.93 +/- 0.96 mm.day-1. In the vegetative development period of rice, the daily ET has achieved 4.94 mm.day-1, with average value 2,31+/- 0.97 mm.day-1. In the period of harvest, evapotranspiration daily average was 1.84 +/- 0.80 mm.day-1. From results obtained, the estimation of evapotranspiration from satellite images may assist in monitoring the culture during the cycle, assisting in estimates of water productivity and crop yield.

SYNAPSE, Symposium for Young Neuroscientists and Professors of the Southeast: A One-day, Regional Neuroscience Meeting Focusing on Undergraduate Research

PubMed Central

Hurd, Mark W.; Lom, Barbara; Silver, Wayne L.

2011-01-01

The Symposium for Young Neuroscientists and Professors of the Southeast (SYNAPSE; synapse.cofc.edu) was designed to encourage contacts among faculty and students interested in neuroscience. Since its inception in 2003, the SYNAPSE conference has consistently drawn faculty and undergraduate interest from the region. This unique meeting provides undergraduates with a valuable opportunity for neuroscience education; students interact with noted neuroscience faculty, present research results, obtain feedback from neuroscientists at other institutions, and form connections with other neuroscientists in the region. Additionally, SYNAPSE allows undergraduate students and faculty to attend workshops and panel discussions about issues related to professional skills and career options. The SYNAPSE conference currently travels among host institutions in the southeastern United States in two-year cycles. This article briefly describes the genesis of SYNAPSE and reviews SYNAPSE conferences from 2006 through 2010. The goal of this paper is to highlight key issues organizers have experienced launching, sustaining, and hosting this regional undergraduate neuroscience conference as well as assist faculty to develop similar conferences. PMID:23493950

Safety measures associated with the use of organophosphate insecticides in the Haitian malaria control programme*

PubMed Central

Warren, McWilson; Ruebush, Trenton K.; Hobbs, Jesse H.; Hippolyte, Robert; Miller, Steve

1985-01-01

A programme emphasizing intensive training, use of protective equipment and uniforms, daily supervision of safety measures at work, and weekly monitoring of blood cholinesterase levels by the tintometric method was instituted to prevent toxicity in Haitian malaria workers during spraying with the organophosphate insecticides fenitrothion and malathion. The programme functioned well, depressed cholinesterase activity (≤ 50% of normal) being detected rapidly prior to the development of serious symptoms. Evidence of fenitrothion overexposure appeared in spraymen early in the first spray cycle, and was associated with faulty protective clothing and a failure to observe strictly the recommended safety measures at work. After these deficiencies were corrected, insecticide application continued without serious incidents or interruption of the programme. No serious reduction of cholinesterase activity was seen in a more limited study of spraymen using malathion. It is strongly recommended that similar training and monitoring programmes should be instituted whenever organophosphate pesticides are used as residual sprays for malaria control. This is particularly important in areas where the more toxic compound, fenitrothion, is to be used. PMID:3874715

76 FR 35223 - National Center for Research Resources; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research... clearly unwarranted invasion of personal privacy. Name of Committee: National Center for Research... cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333...

Savvy Spending

ERIC Educational Resources Information Center

Kennedy, Mike

2009-01-01

In the last several years, the growing demand that education institutions incorporate sustainable design and construction concepts in school facility plans has created a greater emphasis on using life-cycle costing. The use of long-lasting materials and equipment enables schools and universities to avoid the unnecessary consumption of energy and…

Reforming Again: Now Teachers

ERIC Educational Resources Information Center

Marx, Ronald W.

2014-01-01

Background: Educational reform responds to local and national pressures to improve educational outcomes, and reform efforts cycle as similar pressures recur. Currently, reform efforts focus on teachers, even though confidence in a host of American social institutions is dropping. One of the most widespread reforms regarding teachers is the…

Cutting the Roots of Violence.

ERIC Educational Resources Information Center

Koziey, Paul W.

1996-01-01

Violence is rooted in obedience to authority and in comparisons--foundations of our institutions of parenting and schooling. Obedience brings reward and punishment, comparison perpetuates a cycle of competition and conflict. Television violence is especially harmful because children easily understand visual images. The Reality Research approach to…

Prospects for genomic selection in cassava breeding

USDA-ARS?s Scientific Manuscript database

Cassava (Manihot esculenta Crantz) is a clonally propagated staple food crop in the tropics. Genomic selection (GS) has been implemented at three breeding institutions in Africa in order to reduce cycle times. Initial studies provided promising estimates of predictive abilities. Here, we expand on p...

Information Architecture: The Data Warehouse Foundation.

ERIC Educational Resources Information Center

Thomas, Charles R.

1997-01-01

Colleges and universities are initiating data warehouse projects to provide integrated information for planning and reporting purposes. A survey of 40 institutions with active data warehouse projects reveals the kinds of tools, contents, data cycles, and access currently used. Essential elements of an integrated information architecture are…

Proyecto multidisciplinar `Marte nos visita'

NASA Astrophysics Data System (ADS)

Merlo, D.; Merlo, N.; Parodi, B.; Garis, A.; Peralta, G.; Rovessi, V.; Urrutia, S.; Calderón, J.; Bustos Fierro, I.; Melia, R.

The planets Earth and Mars reached in August 2003 the most approximation in the last 58,000 years. In order to that we carried out a transversal study of red planet, joining the knowledges from several subjects of second school year of unified basic cycle (eighth basic general education) at I.P.E.M. No 249 "Nicolás Copérnico" (a public secondary institution from Córdoba, Argentine). In this study, activities in accordance with current contents has been proposed by common consents of each teacher. Besides, students visited Córdoba Astronomical Observatory in order to search informations and received a multimedia exposition about of astronomical event and a performance of the "Carl Sagan" Moveable Planetary. Finally, each student carried out practical works and wrote an integrative report, which one has been evaluated and exposed at ExpoIPEM 2003, an annual exhibition of several specialities that Institution offers in its specialization cycle (10-12 grade), where the annual students' activities are exhibited too (workshops, school projects, etc.).

Closure of a human tissue biobank: individual, institutional, and field expectations during cycles of promise and disappointment

PubMed Central

Stephens, Neil; Dimond, Rebecca

2015-01-01

Biobanks are increasingly being established to act as mediators between patient-donors and researchers. In practice, some of these will close. This paper details the experiences of one such bank. We report interviews with the bank's staff and oversight group during the period when the bank ceased biobanking activity, reconfigured as a disseminator of best practice, before then closing altogether. The paper makes three distinct contributions: (i) to provide a detailed account of the establishment, operational challenges, and eventual closure of the bank, which makes clear the rapid turnover in a cycle of promise and disappointment; (ii) to explore this in terms of a novel analytical focus upon field, institutional, and individual expectations; and (iii) to use this typology to demonstrate how, even after the bank's closure, aspects of its work were reconfigured and reused in new contexts. This provides a unique empirical analysis of the under-reported issue of biobank closure. PMID:26740793

Comprehensive evaluation on low-carbon development of coal enterprise groups.

PubMed

Wang, Bang-Jun; Wu, Yan-Fang; Zhao, Jia-Lu

2017-12-19

Scientifically evaluating the level of low-carbon development in terms of theoretical and practical significance is extremely important to coal enterprise groups for implementing national energy-related systems. This assessment can assist in building institutional mechanisms that are conducive for the economic development of coal business cycle and energy conservation as well as promoting the healthy development of coal enterprises to realize coal scientific development and resource utilization. First, by adopting systematic analysis method, this study builds low-carbon development evaluation index system for coal enterprise groups. Second, to determine the weight serving as guideline and criteria of the index, analytic hierarchy process (AHP) is applied using integrated linear weighted sum method to evaluate the level of low-carbon development of coal enterprise groups. Evaluation is also performed by coal enterprise groups, and the process comprises field analysis and evaluation. Finally, industrial policies are proposed regarding the development of low-carbon coal conglomerate strategies and measures. This study aims mainly to guide the low-carbon development of coal enterprise groups, solve the problem of coal mining and the destruction of ecological environment, support the conservation of raw materials and various resources, and achieve the sustainable development of the coal industry.

Generalized approach for identification and evaluation of technology-insertion options for military avionics systems

NASA Astrophysics Data System (ADS)

Harkness, Linda L.; Sjoberg, Eric S.

1996-06-01

The Georgia Tech Research Institute, sponsored by the Warner Robins Air Logistics Center, has developed an approach for efficiently postulating and evaluating methods for extending the life of radars and other avionics systems. The technique identified specific assemblies for potential replacement and evaluates the system level impact, including performance, reliability and life-cycle cost of each action. The initial impetus for this research was the increasing obsolescence of integrated circuits contained in the AN/APG-63 system. The operational life of military electronics is typically in excess of twenty years, which encompasses several generations of IC technology. GTRI has developed a systems approach to inserting modern technology components into older systems based upon identification of those functions which limit the system's performance or reliability and which are cost drivers. The presentation will discuss the above methodology and a technique for evaluating and ranking the different potential system upgrade options.

Catchments network on badlands around Mediterranean area (RESOBAM)

NASA Astrophysics Data System (ADS)

Copard, Yoann; Lebouteiller, Caroline; Regues-Munoz, David; Latron, Jerome; Solé-Benet, Albert; Canton, Yolanda; Nadal-Romero, Estela; Della Seta, Marta; Rossi, Mauro; Capolongo, Domenico; Maquaire, Olivier; Forey, Estelle; Di-Giovanni, Christian; Gallart, Francesc; Delmonte, Maurizio; Vergari, Francesca; Massei, Nicolas; Torri, Dino

2016-04-01

Between 2013 and 2014, a network funded by MISTRALS-ENVIMED institution, was born around some instrumented catchments developing a badland-type morphology. This network has grouped 3 countries (France, Spain and Italy) with 12 scientific labs. RESOBAM has concerned two sites in France (Draix-Bléone and Vaches Noires), three in Spain (Vallcebre, Araguas and El Cautivo) and some sites in Italy (Tuscany, Basilicata). Main goal of this network was to federate the research around badlands at the European scale, by proposing some scientific topics as: sediment and water transports / budget, (bio)geochemical cycles, agricultural (farming), education, restoration, cultural heritage, soil conservation / biodiversity, climatic change etc. Other main interests were also to propose some common scientific projects and the development of students exchanges. This communication presents the synthesis of our four meetings held at Draix, Zaragoza, Almeriá and Rouen and some perspectives to continue this network.

Virtual reality goes to war: a brief review of the future of military behavioral healthcare.

PubMed

Rizzo, Albert; Parsons, Thomas D; Lange, Belinda; Kenny, Patrick; Buckwalter, John G; Rothbaum, Barbara; Difede, JoAnn; Frazier, John; Newman, Brad; Williams, Josh; Reger, Greg

2011-06-01

Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in returning OEF/OIF military personnel is creating a significant healthcare challenge. These findings have served to motivate research on how to better develop and disseminate evidence-based treatments for PTSD. Virtual Reality delivered exposure therapy for PTSD has been previously used with reports of positive outcomes. This article details how virtual reality applications are being designed and implemented across various points in the military deployment cycle to prevent, identify and treat combat-related PTSD in OIF/OEF Service Members and Veterans. The summarized projects in these areas have been developed at the University of Southern California Institute for Creative Technologies, a U.S. Army University Affiliated Research Center, and this paper will detail efforts to use virtual reality to deliver exposure therapy, assess PTSD and cognitive function and provide stress resilience training prior to deployment.

An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome

PubMed Central

Ahmed, Tahmeed; Auble, David; Berkley, James A; Black, Robert; Ahern, Philip P; Hossain, Muttaquina; Hsieh, Andrea; Ireen, Santhia; Arabi, Mandana; Gordon, Jeffrey I

2014-01-01

The Sackler Institute for Nutrition Science and the World Health Organization (WHO) have worked together to formulate a research agenda for nutrition science. Undernutrition of children has profound effects on health, development, and achievement of full human capacity. Undernutrition is not simply caused by a lack of food, but results from a complex interplay of intra- and intergenerational factors. Representative preclinical models and comprehensive well-controlled longitudinal clinical studies are needed to further understand the contributions and the interrelationships among these factors and to develop interventions that are effective and durable. This paper summarizes work on mechanisms underlying the varied manifestations of childhood undernutrition and discusses current gaps in knowledge and challenges to our understanding of undernutrition and infection/immunity throughout the human life cycle, focusing on early childhood growth. It proposes a series of basic and clinical studies to address this global health challenge. PMID:25118072

Building capacity in health facility management: guiding principles for skills transfer in Liberia

PubMed Central

2010-01-01

Background Management training is fundamental to developing human resources for health. Particularly as Liberia revives its health delivery system, facility and county health team managers are central to progress. Nevertheless, such management skills are rarely prioritized in health training, and sustained capacity building in this area is limited. We describe a health management delivery program in which a north and south institution collaborated to integrate classroom and field-based training in health management and to transfer the capacity for sustained management development in Liberia. Methods We developed and implemented a 6-month training program in health management skills (i.e. strategic problem solving, financial management, human resource management and leadership) delivered by Yale University and Mother Patern College from Liberia, with support from the Clinton HIV/AIDS Initiative. Over three 6-month cycles, responsibility for course instruction was transferred from the north institution to the south institution. A self-administered survey was conducted of all participants completing the course to measure changes in self-rated management skills, the degree to which the course was helpful and met its stated objectives, and faculty members' responsiveness to participant needs as the transfer process occurred. Results Respondents (n = 93, response rate 95.9%) reported substantial improvement in self-reported management skills, and rated the helpfulness of the course and the degree to which the course met its objectives highly. Levels of improvement and course ratings were similar over the three cohorts as the course was transferred to the south institution. We suggest a framework of five elements for implementing successful management training programs that can be transferred and sustained in resource-limited settings, including: 1) use a short-course format focusing on four key skill areas with practical tools; 2) include didactic training, on-site projects, and on-site mentoring; 3) collaborate with an in-country academic institution, willing and able to scale-up and maintain the training; 4) provide training for the in-country academic faculty; and 5) secure Ministry-level support to ensure participation. Conclusion Our findings demonstrate key elements for scaling up and replicating educational initiatives that address management skills essential for long-term health systems strengthening in resource-poor settings. PMID:20298565

Enhancing environmental engineering education in Europe

NASA Astrophysics Data System (ADS)

Caporali, Enrica; Tuneski, Atanasko

2013-04-01

In the frame of knowledge triangle: education-innovation-research, the environmental engineering higher education is here discussed with reference to the TEMPUS-Trans European Mobility Programme for University Studies promoted by the European Commission. Among the focused aspects of TEMPUS are curricula harmonization and lifelong learning programme development in higher education. Two are the curricula, since the first TEMPUS project, coordinated in the period 2005-2008 by University of Firenze in cooperation with colleagues of the Ss Cyril and Methodius University, Skopje. The second three years TEMPUS Joint Project denominated DEREL-Development of Environment and Resources Engineering Learning, is active since October 2010. To the consortium activities participate 4 EU Universities (from Italy, Greece, Germany and Austria), 7 Partner Countries (PC) Universities (from FYR of Macedonia, Serbia and Albania), and 1 PC Ministry, 4 PC National Agencies, 1 PC non governmental organization and 1 PC enterprise. The same 4 EU Universities and the same Macedonian Institutions participated at the first TEMPUS JEP entitled DEREC-Development of Environmental and Resources Engineering Curriculum. Both the first and second cycle curriculum, developed through the co-operation, exchange of know-how and expertise between partners, are based on the European Credit Transfer System and are in accordance with the Bologna Process. Within DEREC a new three-years first cycle curriculum in Environmental and Resources Engineering was opened at the University Ss Cyril and Methodius, Skopje, and the necessary conditions for offering a Joint Degree Title, on the basis of an agreement between the Ss. Cyril and Methodius University and the University of Firenze, were fulfilled. The running DEREL project, as a continuation of DEREC, is aimed to introduce a new, up-to-date, postgraduate second cycle curriculum in Environment and Resources Engineering at the Ss Cyril and Methodius University in Skopje, FYR of Macedonia, University of Novi Sad, Serbia and Polytechnic University of Tirana, Albania, following the criteria and conditions for setting up a Joint Postgraduate Degree. The new second cycle degree curriculum has been just activated in the current academic year 2012/2013. In DEREL a second objective is to implement a sustainable regional network aimed to offer lifelong learning seminars for environment and resources engineering education and training of interested stakeholders and organize workshops focused on strengthening the links in the knowledge triangle: environment education-innovation-research, with participation of postgraduate students, public services, enterprises and NGO's.

APT, The Phase I tool for HST Cycle 12

NASA Astrophysics Data System (ADS)

Blacker, Brett S.; Bertch, Maria; Curtis, Gary; Douglas, Robert E., Jr.; Krueger, Anthony P.

2002-12-01

In the continuing effort to streamline our systems and improve service to the science community, the Space Telescope Science Institute (STScI) is developing and releasing, APT The Astronomer’s Proposal Tool as the new interface for Hubble Space Telescope (HST) Phase I and Phase II proposal submissions for HST Cycle 12. APT, was formerly called the Scientist’s Expert Assistant (SEA), which started as a prototype effort to try and bring state of the art technology, more visual tools and power into the hands of proposers so that they can optimize the scientific return of their programs as well as HST. Proposing for HST and other missions, consists of requesting observing time and/or archival research funding. This step is called Phase I, where the scientific merit of a proposal is considered by a community based peer-review process. Accepted proposals then proceed thru Phase II, where the observations are specified in sufficient detail to enable scheduling on the telescope. In this paper, we will present our concept and implementation plans for our Phase I development and submission tool, APT. More importantly, we will go behind the scenes and discuss why it’s important for the Science Policies Division (SPD) and other groups at the STScI to have a new submission tool and submission output products. This paper is an update of the status of the HST Phase I Proposal Processing System that was described in the published paper “A New Era for HST Phase I Development and Submission.”

Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression.

PubMed

Young, Steven L; Savaris, Ricardo F; Lessey, Bruce A; Sharkey, Andrew M; Balthazar, Ursula; Zaino, Richard J; Sherwin, Robert A; Fritz, Marc A

2017-09-01

What doses of secretory phase progesterone (P) in women are associated with altered endometrial structure and/or function? Consistently delayed histological maturation was seen at the lowest tested daily P dose (2.5 mg), whereas consistently altered functional response, as reflected by microarray analysis of gene expression was seen at both the 5 and 2.5 mg doses. Progesterone is absolutely required for normal embryo implantation and pregnancy survival. Progesterone supplementation is beneficial in ART cycles. In this case-control experimental trial, 46 healthy young female volunteers (age 19-34) underwent a single modeled endometrial cycle after GnRH down-regulation or monitored in natural cycles. In a university hospital, modeled cycles were obtained by GnRH agonist down-regulation, transdermal estradiol (E2) (0.2 mg/d), and daily injections of P in oil for 10 days: 2.5 mg (n = 6), 5 mg (n = 6), 10 mg (n = 12) or 40 mg (n = 12), after the 10th day of E2. Ten healthy, ovulatory women were used as controls. Endometrial biopsies were obtained on the 10th day of P exposure, or urinary LH surge (in controls). Analysis included histological dating, serum progesterone levels, microarray analysis of the whole genome, RT-PCR, western blot and comparison with the GEO database. In endometrial biopsies, a morphological delay appears in the 2.5 mg/day of P group. Higher sub-physiological levels of P (≥5 mg/day) resulted in normal histology, but aberrant gene expression. P levels required for consistent histological delay were lower than those in all ovulatory women. Gene expression abnormalities occurred at higher sub-physiological P concentrations, without a change in histology, a functional-morphological disassociation. The expression of some endometrial receptivity-associated genes appeared multiphasic, with peak or nadir of mean or median expression levels between the lowest and highest doses, suggesting sustained supraphysiological doses seen in ART treatment cycles may not be optimal. GEO DataSets ID: 200056980; GSE 56980. These results were obtained in fertile women, who may respond differently from infertile subjects. The dose of P required for normal endometrial structure (5 mg/day) corresponds to a P concentration well below that seen in ovulatory women, suggesting that persistently delayed mid-secretory histology cannot be solely due to inadequate P concentrations in an ovulatory cycle. Endometrial gene expression is differentially regulated by different doses of progesterone. The apparent multiphasic response of some genes to P dose suggests the possibility that P concentration kinetics may play a role in normal endometrial preparation for receptivity. These findings strongly confirm that histologic development is not a reliable measure of endometrial P action. Supported by The Eunice Kennedy Shriver National Institute for Child Health and Disease, National Institute of Health, USA (NICHD/NIH) (R01HD067721 and U54HD30476; SLY and BAL) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 240239/2012-1 (RFS). All authors have no competing interests. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Global Change Research Related to the Earth's Energy and Hydrologic Cycle

NASA Technical Reports Server (NTRS)

1998-01-01

The Institute for Global Change Research and Education (IGCRE) is a joint initiative of the Universities Space Research Association (USRA) and the University of Alabama in Huntsville (UAH) for coordinating and facilitating research and education relevant to global environmental change. Created in 1992 with primary support from the National Aeronautics and Space Administration (NASA), IGCRE fosters participation by university, private sector and government scientists who seek to develop long-term collaborative research in global change science, focusing on the role of water and energy in the Earth's atmosphere and physical climate system. IGCRE is also chartered to address educational needs of Earth system and global change science, including the preparation of future scientists and training of primary and secondary education teachers.

Vibrational fatigue failures in short cantilevered piping with socket-welding fittings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.K.

1996-12-01

Approximately 80% of the vibrational fatigue failures in nuclear power plants have been caused by high cycle vibrational fatigue. Many of these failures have occurred in short, small bore (2 in. nominal diameter and smaller), unbraced, cantilevered piping with socket-welding fittings. The fatigue failures initiated in the socket welds. These failures have been unexpected, and have caused costly, unscheduled outages in some cases. In order to reduce the number of vibrational fatigue failures in these short cantilevered pipes, an acceleration based vibrational fatigue screening criteria was developed under Electric Power Research Institute (EPRI) sponsorship. In this paper, the acceleration basedmore » criteria will be compared to the results obtained from detailed dynamic modeling of a short, cantilevered pipe.« less

76 FR 16797 - National Center for Research Resources; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research... unwarranted invasion of personal privacy. Name of Committee: National Center for Research Resources Special... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333...

Diversification of Tertiary Education in France.

ERIC Educational Resources Information Center

Didier, Paul

Following an outline of education, particularly secondary education, the French system of tertiary education is described. The orientation of studies offered in the three two-year cycles of study is described. The differences between the national institutes and the universities are explained. The remainder of the report contains admission…

Prerequisite Change and Its Effect on Intermediate Accounting Performance

ERIC Educational Resources Information Center

Huang, Jiunn; O'Shaughnessy, John; Wagner, Robin

2005-01-01

As of Fall 1996, San Francisco State University changed its introductory financial accounting course to focus on a "user's" perspective, de-emphasizing the accounting cycle. Anticipating that these changes could impair subsequent performance, the Department of Accounting instituted a new prerequisite for intermediate accounting: Students would…

Annual Report on Research, 1979 (U.S. Army Research Institute for the Behavioral and Social Sciences)

DTIC Science & Technology

1979-01-01

Research ........................................... 17 Command, Control and Communication (C3) with Automated Battlefield Systems ...19 Life Cycle Systems Management ............................. 22 Cost and Training Effectiveness Analysis ....................... 24 Operational Test...Training Center ................................... 66 Unit Training Programs and Management Systems ............... 68 Personnel and Manpower

Student Learning and the Menstrual Cycle: Myths and Realities.

ERIC Educational Resources Information Center

Richardson, John T. E.

1988-01-01

Available research evidence indicates that the process of menstruation has no effect on academic performance as measured by quantitative tests, and that subjective complaints of paramenstrual dysfunction originate in socially mediated beliefs rather than any objective impairment. The consequences for higher education institutions and student…

Predictive factors of early moderate/severe ovarian hyperstimulation syndrome in non-polycystic ovarian syndrome patients: a statistical model.

PubMed

Ashrafi, Mahnaz; Bahmanabadi, Akram; Akhond, Mohammad Reza; Arabipoor, Arezoo

2015-11-01

To evaluate demographic, medical history and clinical cycle characteristics of infertile non-polycystic ovary syndrome (NPCOS) women with the purpose of investigating their associations with the prevalence of moderate-to-severe OHSS. In this retrospective study, among 7073 in vitro fertilization and/or intracytoplasmic sperm injection (IVF/ICSI) cycles, 86 cases of NPCO patients who developed moderate-to-severe OHSS while being treated with IVF/ICSI cycles were analyzed during the period of January 2008 to December 2010 at Royan Institute. To review the OHSS risk factors, 172 NPCOS patients without developing OHSS, treated at the same period of time, were selected randomly by computer as control group. We used multiple logistic regression in a backward manner to build a prediction model. The regression analysis revealed that the variables, including age [odds ratio (OR) 0.9, confidence interval (CI) 0.81-0.99], antral follicles count (OR 4.3, CI 2.7-6.9), infertility cause (tubal factor, OR 11.5, CI 1.1-51.3), hypothyroidism (OR 3.8, CI 1.5-9.4) and positive history of ovarian surgery (OR 0.2, CI 0.05-0.9) were the most important predictors of OHSS. The regression model had an area under curve of 0.94, presenting an allowable discriminative performance that was equal with two strong predictive variables, including the number of follicles and serum estradiol level on human chorionic gonadotropin day. The predictive regression model based on primary characteristics of NPCOS patients had equal specificity in comparison with two mentioned strong predictive variables. Therefore, it may be beneficial to apply this model before the beginning of ovarian stimulation protocol.

Development and Validation of a Gas-Fired Residential Heat Pump Water Heater - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael Garrabrant; Roger Stout; Paul Glanville

2013-01-21

For gas-fired residential water heating, the U.S. and Canada is predominantly supplied by minimum efficiency storage water heaters with Energy Factors (EF) in the range of 0.59 to 0.62. Higher efficiency and higher cost ($700 - $2,000) options serve about 15% of the market, but still have EFs below 1.0, ranging from 0.65 to 0.95. To develop a new class of water heating products that exceeds the traditional limit of thermal efficiency, the project team designed and demonstrated a packaged water heater driven by a gas-fired ammonia-water absorption heat pump. This gas-fired heat pump water heater can achieve EFs ofmore » 1.3 or higher, at a consumer cost of $2,000 or less. Led by Stone Mountain Technologies Inc. (SMTI), with support from A.O. Smith, the Gas Technology Institute (GTI), and Georgia Tech, the cross-functional team completed research and development tasks including cycle modeling, breadboard evaluation of two cycles and two heat exchanger classes, heat pump/storage tank integration, compact solution pump development, combustion system specification, and evaluation of packaged prototype GHPWHs. The heat pump system extracts low grade heat from the ambient air and produces high grade heat suitable for heating water in a storage tank for domestic use. Product features that include conventional installation practices, standard footprint and reasonable economic payback, position the technology to gain significant market penetration, resulting in a large reduction of energy use and greenhouse gas emissions from domestic hot water production.« less

SiLix-C Nanocomposites

NASA Technical Reports Server (NTRS)

Henry, Francois

2015-01-01

For this Phase II project, Superior Graphite Co., in collaboration with the Georgia Institute of Technology and Streamline Nanotechnologies, Inc., developed, explored the properties of, and demonstrated the enhanced capabilities of novel nanostructured SiLix-C anodes. These anodes can retain high capacity at a rapid 2-hour discharge rate and at 0 C when used in Li-ion batteries. In Phase I, these advanced anode materials had specific capacity in excess of 1,000 mAh/g, minimal irreversible capacity losses, and stable performance for 20 cycles at C/1. The goals in Phase II were to develop and apply a variety of novel nanomaterials, fine-tune the properties of composite particles at the nanoscale, optimize the composition of the anodes, and select appropriate binder and electrolytes. In order to achieve a breakthrough in power characteristics of Li-ion batteries, the team developed new nanostructured SiLix-C anode materials to offer up to 1,200 mAh/g at C/2 at 0 C.

Accelerating Technology Development through Integrated Computation and Experimentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shekhawat, Dushyant; Srivastava, Rameshwar D.; Ciferno, Jared

2013-08-15

This special section of Energy & Fuels comprises a selection of papers presented at the topical conference “Accelerating Technology Development through Integrated Computation and Experimentation”, sponsored and organized by the United States Department of Energy’s National Energy Technology Laboratory (NETL) as part of the 2012 American Institute of Chemical Engineers (AIChE) Annual Meeting held in Pittsburgh, PA, Oct 28-Nov 2, 2012. That topical conference focused on the latest research and development efforts in five main areas related to fossil energy, with each area focusing on the utilization of both experimental and computational approaches: (1) gas separations (membranes, sorbents, and solventsmore » for CO{sub 2}, H{sub 2}, and O{sub 2} production), (2) CO{sub 2} utilization (enhanced oil recovery, chemical production, mineralization, etc.), (3) carbon sequestration (flow in natural systems), (4) advanced power cycles (oxy-combustion, chemical looping, gasification, etc.), and (5) fuel processing (H{sub 2} production for fuel cells).« less

Towards a politics of disaster response: presidential disaster instructions in China, 1998-2012.

PubMed

Tao, Peng; Chen, Chunliang

2018-04-01

China's disaster management system contains no law-based presidential disaster declarations; however, the national leader's instructions (pishi in Chinese) play a similar role to disaster declarations, which increase the intensity of disaster relief. This raises the question of what affects presidential disaster instructions within an authoritarian regime. This research shows that China's disaster politics depend on a crisis threshold system for operation and that the public and social features of disasters are at the core of this system. China's political cycle has no significant impact on disaster politics. A change in the emergency management system has a significant bearing on presidential disaster instructions, reflecting the strong influence of the concept of rule of law and benefiting the sustainable development of the emergency management system. In terms of disaster politics research, unlocking the black box of China's disaster politics and increasing the number of comparative political studies will benefit the development of empirical and theoretical study. © 2018 The Author(s). Disasters © Overseas Development Institute, 2018.

Ellis T. Cox: pragmatist with a public conscience. [Power; environmental concerns of Potomac Electric Co. for Washington, DC area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-05-01

A profile of Potomac Electric Power Co. executive Ellis T. Cox EPRI Advisory Board member the obligation he feels for preserving the unique qualities of the Washington, D.C. area by installing power plant pollution equipment, burning low-sulfur coal, and setting an example of concern for other companies and the legislators. Cox feels a commitment to not only meet civic responsibilities, but to demonstrate that an efficient, cost-effective company can also protect the environment. He sets long-term fuel supplies as a high priority for utility research and development and sees no alternative to shifts away from petroleum and further development ofmore » nuclear generating power. His other concerns are for streamlining the regulatory process, demonstrating the Civex process as an alternative fuel cycle, and a continuation of the joint efforts of utilities and the Electric Power Research Institute to solve practical problems of pollution control and develop new fuels and new combustion technologies.« less

Gender issues in reproductive health: a review.

PubMed

Adinma, Echendu D; Adinma, Brian-D J I

2011-01-01

Gender, for its impact on virtually every contemporary life issue, can rightly be regarded as a foremost component of reproductive health. Reproductive health basically emphasises on people and their rights to sexuality, reproduction, and family planning, and the information to actualize these right, which has been inextricably linked to development at the International Conference on Population and Development (ICPD) held in Cairo, Egypt, in 1994. Women's sexual and reproductive rights became recognised as universal human right, violations of which occur in some reproductive health areas including gender concerns. Gender inequality and inequity encompass gender based violence as well as gender discrimination which cuts across the life cycle of the woman; attitudes, religious and cultural practices of various nations; and issues related to employment, economy, politics, and development. The redress of gender inequality is a collective responsibility of nations and supranational agencies. Nations should adopt a framework hinged on three pedestals--legal, institutional and policy, employing the three recommended approaches of equal treatment, positive action, and gender mainstreaming.

The 2011 flood event in the Mekong Delta: preparedness, response, damage and recovery of private households and small businesses.

PubMed

Chinh, Do Thi; Bubeck, Philip; Dung, Nguyen Viet; Kreibich, Heidi

2016-10-01

Floods frequently cause substantial economic and human losses, particularly in developing countries. For the development of sound flood risk management schemes that reduce flood consequences, detailed insights into the different components of the flood risk management cycle, such as preparedness, response, flood impact analyses and recovery, are needed. However, such detailed insights are often lacking: commonly, only (aggregated) data on direct flood damage are available. Other damage categories such as losses owing to the disruption of production processes are usually not considered, resulting in incomplete risk assessments and possibly inappropriate recommendations for risk management. In this paper, data from 858 face-to-face interviews among flood-prone households and small businesses in Can Tho city in the Vietnamese Mekong Delta are presented to gain better insights into the damage caused by the 2011 flood event and its management by households and businesses. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.

Quality improvement utilizing in-situ simulation for a dual-hospital pediatric code response team.

PubMed

Yager, Phoebe; Collins, Corey; Blais, Carlene; O'Connor, Kathy; Donovan, Patricia; Martinez, Maureen; Cummings, Brian; Hartnick, Christopher; Noviski, Natan

2016-09-01

Given the rarity of in-hospital pediatric emergency events, identification of gaps and inefficiencies in the code response can be difficult. In-situ, simulation-based medical education programs can identify unrecognized systems-based challenges. We hypothesized that developing an in-situ, simulation-based pediatric emergency response program would identify latent inefficiencies in a complex, dual-hospital pediatric code response system and allow rapid intervention testing to improve performance before implementation at an institutional level. Pediatric leadership from two hospitals with a shared pediatric code response team employed the Institute for Healthcare Improvement's (IHI) Breakthrough Model for Collaborative Improvement to design a program consisting of Plan-Do-Study-Act cycles occurring in a simulated environment. The objectives of the program were to 1) identify inefficiencies in our pediatric code response; 2) correlate to current workflow; 3) employ an iterative process to test quality improvement interventions in a safe environment; and 4) measure performance before actual implementation at the institutional level. Twelve dual-hospital, in-situ, simulated, pediatric emergencies occurred over one year. The initial simulated event allowed identification of inefficiencies including delayed provider response, delayed initiation of cardiopulmonary resuscitation (CPR), and delayed vascular access. These gaps were linked to process issues including unreliable code pager activation, slow elevator response, and lack of responder familiarity with layout and contents of code cart. From first to last simulation with multiple simulated process improvements, code response time for secondary providers coming from the second hospital decreased from 29 to 7 min, time to CPR initiation decreased from 90 to 15 s, and vascular access obtainment decreased from 15 to 3 min. Some of these simulated process improvements were adopted into the institutional response while others continue to be trended over time for evidence that observed changes represent a true new state of control. Utilizing the IHI's Breakthrough Model, we developed a simulation-based program to 1) successfully identify gaps and inefficiencies in a complex, dual-hospital, pediatric code response system and 2) provide an environment in which to safely test quality improvement interventions before institutional dissemination. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Regional forecasting system of marine state and variability of dynamical processes in the easternmost part of the Black Sea

NASA Astrophysics Data System (ADS)

Kordzadze, Avtandil; Demetrashvili, Demuri

2014-05-01

The regional forecasting system for the easternmost part of the Black Sea developed at M. Nodia Institute of Geophysics of I. Javakhishvili Tbilisi State University under the EU framework projects ARENA and ECOOP is a part of the Black Sea basin-scale Nowcasting/Forecasting System. A core of the regional forecasting system is a baroclinic regional model of Black Sea dynamics with 1 km spacing based on hydrostatic primitive equations of ocean hydrothermodynamics, which are written in z-coordinates for deviations of thermodynamic values from their standard vertical distributions. To solve the problem the two-cycle method of splitting the model equation system with respect to both physical processes and coordinate planes and lines is used. The regional model of M. Nodia Institute of Geophysics is nested in the basin-scale model of Black Sea dynamics of Marine Hydrophysical Institute (Sevastopol/Ukraine). The regional forecasting system provides 3 days' forecasts of current, temperature and salinity for the easternmost part of the Black Sea, which is limited to the Caucasian and Turkish coastal lines and the western liquid boundary coinciding with the meridian 39.080E. Data needed on liquid and upper boundaries, also the 3-D initial hydrophysical fields for the easternmost regional area are provided in near operative mode from Marine hydrophysical Institute via Internet. These data on the liquid boundary are values of velocity components, temperature and salinity predicted by the basin-scale model of Black Sea dynamics of Marine Hydrophysical Institute and on the sea surface 2-D meteorological boundary fields - wind stress, heat fluxes, evaporation and precipitation rates predicted by the regional atmospheric model ALADIN are used. The analysis of the results of modeling and forecast of dynamic processes developed for 2010-2014 showed that the easternmost water area of the Black Sea is a dynamically very active zone, where continuously there are processes of generation, deformation and disappearance of the cyclonic and anticyclonic vortex formations of different sizes. Acknowledgement. The significant part of the researches was supported by the Shota Rustaveli National Science Foundation, Grant No. AR/373/9-120/12.

78 FR 47012 - Developing Software Life Cycle Processes Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes Used in... revised regulatory guide (RG), revision 1 of RG 1.173, ``Developing Software Life Cycle Processes for... Developing a Software Project Life Cycle Process,'' issued 2006, with the clarifications and exceptions as...

34 CFR 606.1 - What is the Developing Hispanic-Serving Institutions Program?

Code of Federal Regulations, 2011 CFR

2011-07-01

... INSTITUTIONS PROGRAM General § 606.1 What is the Developing Hispanic-Serving Institutions Program? The purpose of the Developing Hispanic-Serving Institutions Program is to provide grants to eligible institutions... 34 Education 3 2011-07-01 2011-07-01 false What is the Developing Hispanic-Serving Institutions...

Minding the gaps: new insights into R&D management and operational transitions of NOAA satellite products

NASA Astrophysics Data System (ADS)

Colton, Marie C.; Powell, Alfred M.; Jordan, Gretchen; Mote, Jonathon; Hage, Jerald; Frank, Donald

2004-10-01

The NESDIS Center for Satellite Applications and Research (STAR), formerly ORA, Office of Research and Applications, consists of three research and applications divisions that encompass satellite meteorology, oceanography, climatology, and cooperative research with academic institutions. With such a wide background of talent, and a charter to develop operational algorithms and applications, STAR scientists develop satellite-derived land, ice, ocean, and atmospheric environmental data products in support of all of NOAA"s mission goals. In addition, in close association with the Joint Center for Satellite Data Assimilation, STAR scientists actively work with the numerical modeling communities of NOAA, NASA, and DOD to support the development of new methods for assimilation of satellite data. In this new era of observations from many new satellite instruments, STAR aims to effectively integrate these data into multi-platform data products for utilization by the forecast and applications communities. Much of our work is conducted in close partnerships with other agencies, academic institutes, and industry. In order to support the nearly 400 current satellite-derived products for various users on a routine basis from our sister operations office, and to evolve to future systems requires an ongoing strategic planning approach that maps research and development activities from NOAA goals to user requirements. Since R&D accomplishments are not necessarily amenable to precise schedules, appropriate motivators and measures of scientific progress must be developed to assure that the product development cycle remains aligned with the other engineering segments of a satellite program. This article presents the status and results of this comprehensive effort to chart a course from the present set of operational satellites to the future.

Myeloablative therapy against high risk Ewing's sarcoma: A single institution experience and literature review

PubMed Central

Lopez, Jose Luis; Pérez, Concepcion; Marquez, Catalina; Cabrera, Patricia; Perez, Jose Maria; Ramirez, Gema Lucia; Ordoñez, Rafael; Praena-Fernandez, Juan Manuel; Ortiz, Maria Jose

2011-01-01

Background Attempts to improve survival outcomes of patients with high risk Ewing's sarcoma (ES) have focused on chemotherapy dose intensification strategies. Aim The objective of this study is to retrospectively evaluate clinical characteristics and outcome of pediatric patients with high risk ES treated at a single institution. Materials and methods From 1995 to 2008, seventeen patients (male:female, 14:3) were treated with dose-intensive therapy in our institution. Median age at diagnosis was 10 years (range: 2–15). Seven patients had metastases at diagnosis (lung in 6 cases and bone in one case). Eleven patients presented with unresectable disease. Fifteen (88.2%) received the Spanish Society of Pediatric Oncology protocol which includes six cycles of vincristine, doxorubicin, ifosfamide and etoposide. Two out of the six cases that were resectable received postoperative radiation. In addition, eleven patients received definitive radiation therapy. Finally, twelve (70.5%) out of 17 patients received myeloablative therapy with melphalan/etoposide. The rest of patients (N = 5) received busulfan/melphalan. Results Median follow-up was 78 months (range: 15–155 months). Initial responses were complete in all patients, but 9 of them developed progression disease. Seven patients became long-term event-free survivors. No patient died of toxicity after transplantation. The 2- and 5-year overall survival rates for all patients were 93% and 73%, respectively. Event-free survival rates were 74% and 54% at 2 and 5 years, respectively. Conclusion This single-institution experience suggests that myeloablative therapy against high risk ES is effective and safe. PMID:24376974

Longitudinal changes in prevalence of respiratory symptoms among Canadian grain elevator workers.

PubMed

Pahwa, Punam; McDuffie, Helen H; Dosman, James A

2006-06-01

To determine longitudinal changes in the prevalence of chronic respiratory symptoms among Canadian grain workers. Data on respiratory symptoms, smoking status, and pulmonary function were obtained approximately every 3 years (termed cycle) over 15 years beginning in 1978 from five regions of Canada. The number of grain workers participating in each cycle were as follows: cycle 1 (n = 5,702); cycle 2 (n = 5,491); cycle 3 (n = 3,713); cycle 4 (n = 2,847); and cycle 5 (n = 3,079). A procedure based on generalized estimating equations (PROC GENMOD; SAS Institute; Cary, NC) was used to fit marginal models to determine risk factors influencing the prevalence of chronic respiratory symptoms (wheeze, dyspnea, sputum, and cough). The prevalence (predicted probability based on the final model) of chronic respiratory symptoms had an increasing trend with increasing number of years in the grain industry from cycle 1 to cycle 3 (before dust control) for all three smoking categories (current smokers, ex-smokers, and nonsmokers). For cycle 4 and cycle 5 (after dust control), there was a reduction in the prevalence of these respiratory symptoms. For example, in cycle 1, the prevalence of chronic wheeze among current smoking grain workers increased from 12% (for those in the industry for < 5 years) to 44% (for those in the industry for > 35 years); in cycle 5, the prevalence of chronic wheeze among current smoking grain workers increased from 9% (for those in the industry for < 5 years) to 28% (for those in the industry for > 35 years). Similar trends were observed for ex-smokers and nonsmokers and for other chronic respiratory symptoms. Our results indicate that grain dust control was effective in reducing the prevalence of chronic respiratory symptoms among grain workers in all smoking and exposure categories.

EDOS operations concept and development approach

NASA Technical Reports Server (NTRS)

Knoble, G.; Garman, C.; Alcott, G.; Ramchandani, C.; Silvers, J.

1994-01-01

The Earth Observing System (EOS) Data and Operations System (EDOS) is being developed by the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) for the capture, level zero processing, distribution, and backup archiving of high speed telemetry data received from EOS spacecraft. All data received will conform to the Consultative Committee for Space Data Standards (CCSDS) recommendations. The major EDOS goals are to: (1) minimize EOS program costs to implement and operate EDOS; (2) respond effectively to EOS growth requirements; and (3) maintain compatibility with existing and enhanced versions of NASA institutional systems required to support EOS spacecraft. In order to meet these goals, the following objectives have been defined for EDOS: (1) standardize EDOS interfaces to maximize utility for future requirements; (2) emphasize life-cycle cost (LCC) considerations (rather than procurement costs) in making design decisions and meeting reliability, maintainability, availability (RMA) and upgradability requirements; (3) implement data-driven operations to the maximum extent possible to minimize staffing requirements and to maximize system responsiveness; (4) provide a system capable of simultaneously supporting multiple spacecraft, each in different phases of their life-cycles; (5) provide for technology insertion features to accommodate growth and future LCC reductions during the operations phase; and (6) provide a system that is sufficiently robust to accommodate incremental performance upgrades while supporting operations. Operations concept working group meetings were facilitated to help develop the EDOS operations concept. This provided a cohesive concept that met with approval of responsible personnel from the start. This approach not only speeded up the development process by reducing review cycles, it also provided a medium for generating good ideas that were immediately molded into feasible concepts. The operations concept was then used as a basis for the EDOS specification. When it was felt that concept elements did not support detailed requirements, the facilitator process was used to resolve discrepancies or to add new concept elements to support the specification. This method provided an ongoing revisal of the operations concept and prevented large revisions at the end of the requirement analysis phase of system development.

Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle.

PubMed

Patel, Pooja; De Boer, Leonore; Timms, Peter; Huston, Wilhelmina May

2014-08-01

Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle. Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

RDMO - Research Data Management Organiser

NASA Astrophysics Data System (ADS)

Klar, Jochen; Engelhardt, Claudia; Neuroth, Heike; Enke, Harry; Ludwig, Jens

2017-04-01

The Research Data Management Organiser (RDMO) is a new tool to support the structured planning and implementation of the research data management in a scientific project and, in addition, provide the scientist with a textual Data Management Plan (DMP). While DMP are in principle a great tool to optimise the data management during all stages of a research project and to serve as a roadmap for the various data management tasks, their current usage is strongly focused on the requirements of funding agencies. Existing software tools for DMP creation and editing are useful in that respect, but do not sufficiently support the full data life cycle of a project. The RDMO is meant to be a companion for data management issues during and after the whole project. Starting from a structured interview about the project and the data involved, it organizes the data management along tasks and comprises all relevant stakeholders, i.e. researchers, PIs, institutional data managers, IT departments. Adaptations to discipline-specific or institutional needs are supported. The installation of the tool into local environments and its integration into existing administrative IT infrastructure and work flows is given special consideration. The tool is multilingual (at first German and English). In my talk, I will present the different features of the software, show its current stage of development, and how RDMO can be deployed for your institution.

Recent Improvement Of The Institutional Radioactive Waste Management System In Slovenia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sueiae, S.; Fabjan, M.; Hrastar, U.

2008-07-01

The task of managing institutional radioactive waste was assigned to the Slovenian National Agency for Radwaste Management by the Governmental Decree of May 1999. This task ranges from the collection of waste at users' premises to the storage in the Central Storage Facility in (CSF) and afterwards to the planned Low and Intermediate Level Waste (LILW) repository. By this Decree ARAO also became the operator of the CSF. The CSF has been in operation since 1986. Recent improvements of the institutional radioactive waste management system in Slovenia are presented in this paper. ARAO has been working on the reestablishment ofmore » institutional radioactive waste management since 1999. The Agency has managed to prepare the most important documents and carry out the basic activities required by the legislation to assure a safe and environmentally acceptable management of the institutional radioactive waste. With the aim to achieve a better organized operational system, ARAO took the advantage of the European Union Transition Facility (EU TF) financing support and applied for the project named 'Improvement of the management of institutional radioactive waste in Slovenia via the design and implementation of an Information Business System'. Through a public invitation for tenders one of the Slovenian largest software company gained the contract. Two international radwaste experts from Belgium were part of their project team. The optimization of the operational system has been carried out in 2007. The project was executed in ten months and it was divided into two phases. The first phase of the project was related with the detection of weaknesses and implementation of the necessary improvements in the current ARAO operational system. With the evaluation of the existing system, possible improvements were identified. In the second phase of the project the software system Information Business System (IBS) was developed and implemented by the group of IT experts. As a software development life-cycle methodology the Waterfall methodology was used. The reason for choosing this methodology lied in its simple approach: analyze the problem, design the solution, implement the code, test the code, integrate and deploy. ARAO's institutional radioactive waste management process was improved in the way that it is more efficient, better organized, allowing traceability and availability of all documents and operational procedures within the field of institutional radioactive waste. The tailored made IBS system links all activities of the institutional radioactive waste management process: collection, transportation, takeover, acceptance, storing, treatment, radiation protection, etc. into one management system. All existing and newly designed evidences, operational procedures and other documents can be searched and viewed via secured Internet access from different locations. (authors)« less

34 CFR 606.2 - What institutions are eligible to receive a grant under the Developing Hispanic-Serving...

Code of Federal Regulations, 2011 CFR

2011-07-01

... the Developing Hispanic-Serving Institutions Program? 606.2 Section 606.2 Education Regulations of the... EDUCATION DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM General § 606.2 What institutions are eligible to receive a grant under the Developing Hispanic-Serving Institutions Program? (a) An institution of higher...

34 CFR 606.2 - What institutions are eligible to receive a grant under the Developing Hispanic-Serving...

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Developing Hispanic-Serving Institutions Program? 606.2 Section 606.2 Education Regulations of the... EDUCATION DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM General § 606.2 What institutions are eligible to receive a grant under the Developing Hispanic-Serving Institutions Program? (a) An institution of higher...

Molecular isomerization induced by ultrashort infrared pulses. I. Few-cycle to sub-one-cycle Gaussian pulses and the role of the carrier-envelope phase.

PubMed

Uiberacker, Christoph; Jakubetz, Werner

2004-06-22

Using 550 previously calculated vibrational energy levels and dipole moments we performed simulations of the HCN-->HNC isomerization dynamics induced by sub-one-cycle and few-cycle IR pulses, which we represent as Gaussian pulses with 0.25-2 optical cycles in the pulse width. Starting from vibrationally pre-excited states, isomerization probabilities of up to 50% are obtained for optimized pulses. With decreasing number of optical cycles a strong dependence on the carrier-envelope phase (CEP) emerges. Although the optimized pulse parameters change significantly with the number of optical cycles, the distortion by the Gaussian envelope produces nearly equal fields, with a positive lobe followed by a negative one. The positions and areas of the lobes are also almost unchanged, irrespective of the number of cycles in the half-width. Isomerization proceeds via a pump-dumplike mechanism induced by the sequential lobes. The first lobe prepares a wave packet incorporating many delocalized states above the barrier. It is the motion of this wave packet across the barrier, which determines the timing of the pump and dump lobes. The role of the pulse parameters, and in particular of the CEP, is to produce the correct lobe sequence, size and timing within a continuous pulse. (c) 2004 American Institute of Physics.

Analysis of the weekly cycle in the atmosphere near Moscow

NASA Astrophysics Data System (ADS)

Gruzdev, A. N.

2013-03-01

Using the spectral method and the method of grouping by days of week, we analyzed the weekly cycles by standard air sounding data obtained at the Dolgoprudny station near Moscow and by the results of measurements of NO2 content in the stratosphere and the atmospheric boundary layer at the Zvenigorod Research Station of the Obukhov Institute of Atmospheric Physics, Russian Academy of Sciences, in 1990-2010. We revealed weekly cycles of the NO2 content in the vertical column of the stratosphere, temperature, geopotential, meridional wind velocity in the troposphere and lower stratosphere, and the tropopause height in the warm half of the year (mid-April to mid-October). The weekly variations in temperature in the troposphere are positive in the first half of the week and negative in the second half, and the variations in temperature in the tropopause layer and in the lower stratosphere are opposite in sign to the tropospheric variations. The weekly cycle of the tropopause height is approximately in phase with the cycle of tropospheric temperature, and the weekly cycle of the NO2 content in the stratospheric column is opposite in phase to the cycle of the tropopause height. Weekly variations were also observed in the total ozone content over Moscow. This finding was confirmed by calculations based on regression relationships between the vertical distribution of ozone and tropopause height. Conceptual mechanisms of weekly cycles were proposed.

Satellite Remote Sensing is Key to Water Cycle Integrator

NASA Astrophysics Data System (ADS)

Koike, T.

2016-12-01

To promote effective multi-sectoral, interdisciplinary collaboration based on coordinated and integrated efforts, the Global Earth Observation System of Systems (GEOSS) is now developing a "GEOSS Water Cycle Integrator (WCI)", which integrates "Earth observations", "modeling", "data and information", "management systems" and "education systems". GEOSS/WCI sets up "work benches" by which partners can share data, information and applications in an interoperable way, exchange knowledge and experiences, deepen mutual understanding and work together effectively to ultimately respond to issues of both mitigation and adaptation. (A work bench is a virtual geographical or phenomenological space where experts and managers collaborate to use information to address a problem within that space). GEOSS/WCI enhances the coordination of efforts to strengthen individual, institutional and infrastructure capacities, especially for effective interdisciplinary coordination and integration. GEOSS/WCI archives various satellite data to provide various hydrological information such as cloud, rainfall, soil moisture, or land-surface snow. These satellite products were validated using land observation in-situ data. Water cycle models can be developed by coupling in-situ and satellite data. River flows and other hydrological parameters can be simulated and validated by in-situ data. Model outputs from weather-prediction, seasonal-prediction, and climate-prediction models are archived. Some of these model outputs are archived on an online basis, but other models, e.g., climate-prediction models are archived on an offline basis. After models are evaluated and biases corrected, the outputs can be used as inputs into the hydrological models for predicting the hydrological parameters. Additionally, we have already developed a data-assimilation system by combining satellite data and the models. This system can improve our capability to predict hydrological phenomena. The WCI can provide better predictions of the hydrological parameters for integrated water resources management (IWRM) and also assess the impact of climate change and calculate adaptation needs.

Ending the Tech Refresh Nightmare

ERIC Educational Resources Information Center

Demski, Jennifer

2010-01-01

As higher education budgets tighten in the ongoing recession, colleges and universities have found themselves questioning, lengthening, and even eliminating tech refresh cycles. Yet how deep an institution cuts into its refresh program can compromise its ability to provide an up-to-date and competitive computing environment for students and a…

A Multilevel Competing Risks Model for Analysis of University Students' Careers in Italy

ERIC Educational Resources Information Center

Meggiolaro, Silvia; Giraldo, Anna; Clerici, Renata

2017-01-01

This paper examines individual and institutional characteristics which may influence the outcomes of university students' careers. Withdrawals, course changes, delays and graduations of students enrolled in first-cycle degree courses in a large public university in Italy are examined. Individual longitudinal data from administrative archives were…

Schools and Disadvantage

ERIC Educational Resources Information Center

Smith, Emma

2011-01-01

The three books reviewed in this essay all have a similar theme: the role that schools and other institutions can play in improving the life-chances of young people and breaking the cycle of socio-economic disadvantage and low educational attainment that is characteristic of school systems around the world. Through an evaluation of the Academies…

78 FR 16859 - Office of the Director, National Institutes of Health; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.14, Intramural Research Training....936, NIH Acquired Immunodeficiency Syndrome Research Loan Repayment Program; 93.187, Undergraduate... Programs Special Emphasis Panel; Research Resource of Human Organs and Tissues. Date: April 2, 2013. Time...

From Elites to Everybody: A Changing Agenda for Sport Sociological Study.

ERIC Educational Resources Information Center

Coakley, Jay J.

1983-01-01

Sociology of sport research has focused on describing sports and sports participants. Future research should study: (1) structural diversity of sports programs and their implications for behavior; (2) participation of males and females throughout the life cycle; and (3) links between sports and other social institutions. (PP)

76 FR 18248 - Sulfanilic Acid From China and India

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United... of business proprietary information (BPI) under an administrative protective order (APO) and APO... to This Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

75 FR 9252 - Magnesium From China and Russia

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... Verratti, Deputy Agency Ethics Official, at 202- 205-3088. Limited disclosure of business proprietary... this Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

78 FR 40172 - Steel Nails From China; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for... of business proprietary information (BPI) under an administrative protective order (APO) and APO... producer or exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or...

77 FR 32669 - Ammonium Nitrate from Ukraine Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United... Official, at 202-205-3088. Limited disclosure of business proprietary information (BPI) under an... business association, or another interested party (including an explanation). If you are a union/worker...

77 FR 5049 - Pure Magnesium From China; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO... Subject Merchandise, a U.S. or foreign trade or business association, or another interested party...

77 FR 12614 - Activated Carbon From China; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information..., a U.S. or foreign trade or business association, or another interested party (including an...

The Returns to Community College

ERIC Educational Resources Information Center

Agan, Amanda Yvonne

2013-01-01

Almost half of postsecondary students are currently enrolled in community colleges. These institutions imply that even amongst students with the same degree outcome there is considerable heterogeneity in the path taken to get there. I estimate the life-cycle private and social returns to the different postsecondary paths and sequential decisions…

78 FR 39319 - Laminated Woven Sacks From China; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information... Subject Merchandise, a U.S. or foreign trade or business association, or another interested party...

75 FR 74746 - Solid Urea From Russia and Ukraine

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO... To this Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

75 FR 28810 - National Institute of General Medical Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-24

... funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.375, Minority Biomedical Research Support; 93.821, Cell Biology and Biophysics Research; 93.859, Pharmacology, Physiology, and Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

Sustaining Transformation: "Resiliency in Hard Times"

ERIC Educational Resources Information Center

Guarasci, Richard; Lieberman, Devorah

2009-01-01

The strategic, systemic, and encompassing evolution of a college or university spans a number of years, and the vagaries of economic cycles inevitably catch transforming institutions in mid-voyage. "Sustaining Transformation: Resiliency in Hard Times" presents a study of Wagner College as it moves into its second decade of purposeful…

MMPM - Mission implementation of Mars MetNet Precursor

NASA Astrophysics Data System (ADS)

Harri, A.-M.

2009-04-01

We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The key technical aspects and solutions of the mission will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

Impact of a statistical bias correction on the projected simulated hydrological changes obtained from three GCMs and two hydrology models

NASA Astrophysics Data System (ADS)

Hagemann, Stefan; Chen, Cui; Haerter, Jan O.; Gerten, Dieter; Heinke, Jens; Piani, Claudio

2010-05-01

Future climate model scenarios depend crucially on their adequate representation of the hydrological cycle. Within the European project "Water and Global Change" (WATCH) special care is taken to couple state-of-the-art climate model output to a suite of hydrological models. This coupling is expected to lead to a better assessment of changes in the hydrological cycle. However, due to the systematic model errors of climate models, their output is often not directly applicable as input for hydrological models. Thus, the methodology of a statistical bias correction has been developed, which can be used for correcting climate model output to produce internally consistent fields that have the same statistical intensity distribution as the observations. As observations, global re-analysed daily data of precipitation and temperature are used that are obtained in the WATCH project. We will apply the bias correction to global climate model data of precipitation and temperature from the GCMs ECHAM5/MPIOM, CNRM-CM3 and LMDZ-4, and intercompare the bias corrected data to the original GCM data and the observations. Then, the orginal and the bias corrected GCM data will be used to force two global hydrology models: (1) the hydrological model of the Max Planck Institute for Meteorology (MPI-HM) consisting of the Simplified Land surface (SL) scheme and the Hydrological Discharge (HD) model, and (2) the dynamic vegetation model LPJmL operated by the Potsdam Institute for Climate Impact Research. The impact of the bias correction on the projected simulated hydrological changes will be analysed, and the resulting behaviour of the two hydrology models will be compared.

Seasonal and interannual variability of fast ice extent in the southeastern Laptev Sea between 1999 and 2013

NASA Astrophysics Data System (ADS)

Selyuzhenok, V.; Krumpen, T.; Mahoney, A.; Janout, M.; Gerdes, R.

2015-12-01

Along with changes in sea ice extent, thickness, and drift speed, Arctic sea ice regime is characterized by a decrease of fast ice season and reduction of fast ice extent. The most extensive fast ice cover in the Arctic develops in the southeastern Laptev Sea. Using weekly operational sea ice charts produced by Arctic and Antarctic Research Institute (AARI, Russia) from 1999 to 2013, we identified five main key events that characterize the annual evolution of fast ice in the southeastern Laptev Sea. Linking the occurrence of the key events with the atmospheric forcing, bathymetry, freezeup, and melt onset, we examined the processes driving annual fast ice cycle. The analysis revealed that fast ice in the region is sensitive to thermodynamic processes throughout a season, while the wind has a strong influence only on the first stages of fast ice development. The maximal fast ice extent is closely linked to the bathymetry and local topography and is primarily defined by the location of shoals, where fast ice is likely grounded. The annual fast ice cycle shows significant changes over the period of investigation, with tendencies toward later fast ice formation and earlier breakup. These tendencies result in an overall decrease of the fast ice season by 2.8 d/yr, which is significantly higher than previously reported trends.

Sharing lessons learned and best practices in deactivation and decommissioning techniques among U.S. Department of Energy contractors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lackey, Michael B.; Waisley, Sandra L.; Dusek, Lansing G.

2007-07-01

Approximately $153.2 billion of work currently remains in the United States Department of Energy's (DOE's) Office of Environmental Management (EM) life cycle budget for United States projects. Contractors who manage facilities for the DOE have been challenged to identify transformational changes to reduce the life cycle costs and develop a knowledge management system that identifies, disseminates, and tracks the implementation of lessons learned and best practices. At the request of the DOE's EM Office of Engineering and Technology, the Energy Facility Contractors Group (EFCOG) responded to the challenge with formation of the Deactivation and Decommissioning (D and D) and Facilitymore » Engineering (DD/FE) Working Group. Since October 2006, members have already made significant progress in realizing their goals: adding new D and D best practices to the existing EFCOG Best Practices database; participating in lessons learned forums; and contributing to a DOE initiative on identifying technology needs. The group is also participating in a DOE project management initiative to develop implementation guidelines, as well as a DOE radiation protection initiative to institute a more predictable and standardized approach to approving authorized limits and independently verifying cleanup completion at EM sites. Finally, a D and D hotline to provide real-time solutions to D and D challenges is also being launched. (authors)« less

Increase Return on Investment of Software Development Life Cycle by Managing the Risk - A Case Study

DTIC Science & Technology

2015-04-01

for increasing the return on investment during the Software Development Life Cycle ( SDLC ) through selected quantitative analyses employing both the...defect rate, return on investment (ROI), software development life cycle ( SDLC ) DE FE N SE A C Q U IS IT IO N UN IVERSITY ALU M N I A SSO C IATIO N R...becomes comfortable due to its intricacies and learning cycle. The same may be said with respect to software development life cycle ( SDLC ) management

United States Advanced Ultra-Supercritical Component Test Facility for 760°C Steam Power Plants ComTest Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hack, Horst; Purgert, Robert Michael

Following the successful completion of a 15-year effort to develop and test materials that would allow coal-fired power plants to be operated at advanced ultra-supercritical (A-USC) steam conditions, a United States-based consortium is presently engaged in a project to build an A-USC component test facility (ComTest). A-USC steam cycles have the potential to improve cycle efficiency, reduce fuel costs, and reduce greenhouse gas emissions. Current development and demonstration efforts are focused on enabling the construction of A-USC plants, operating with steam temperatures as high as 1400°F (760°C) and steam pressures up to 5000 psi (35 MPa), which can potentially increasemore » cycle efficiencies to 47% HHV (higher heating value), or approximately 50% LHV (lower heating value), and reduce CO 2 emissions by roughly 25%, compared to today’s U.S. fleet. A-USC technology provides a lower-cost method to reduce CO 2 emissions, compared to CO 2 capture technologies, while retaining a viable coal option for owners of coal generation assets. Among the goals of the ComTest facility are to validate that components made from advanced nickel-based alloys can operate and perform under A-USC conditions, to accelerate the development of a U.S.-based supply chain for the full complement of A-USC components, and to decrease the uncertainty of cost estimates for future A-USC power plants. The configuration of the ComTest facility would include the key A-USC technology components that were identified for expanded operational testing, including a gas-fired superheater, high-temperature steam piping, steam turbine valve, and cycling header component. Membrane walls in the superheater have been designed to operate at the full temperatures expected in a commercial A-USC boiler, but at a lower (intermediate) operating pressure. This superheater has been designed to increase the temperature of the steam supplied by the host utility boiler up to 1400°F (760°C). The steam turbine stop and control valve component has been designed to operate at full A-USC temperatures, and would be tested both in throttling operation and to accumulate accelerated, repetitive stroke cycles. A cycling header component has been designed to confirm the suitability of new high-temperature nickel alloys to cycling operation, expected of future coal-fired power plants. Current test plans would subject these components to A-USC operating conditions for at least 8,000 hours by September 2020. The ComTest project is managed by Energy Industries of Ohio, and technically directed by the Electric Power Research Institute, Inc., with General Electric designing the A-USC components. This consortium is completing the Detailed Engineering phase of the project, with procurement scheduled to begin in late 2017. The effort is primarily funded by the U.S. Department of Energy, through the National Energy Technology Laboratory, along with the Ohio Development Services Agency. This presentation outlines the motivation for the project, explains the project’s structure and schedule, and provides technical details on the design of the ComTest facility.« less

Magnetic resonance imaging (MRI) of hormone-induced breast changes in young premenopausal women.

PubMed

Clendenen, Tess V; Kim, Sungheon; Moy, Linda; Wan, Livia; Rusinek, Henry; Stanczyk, Frank Z; Pike, Malcolm C; Zeleniuch-Jacquotte, Anne

2013-01-01

We conducted a pilot study to identify whether MRI parameters are sensitive to hormone-induced changes in the breast during the natural menstrual cycle and whether changes could also be observed during an oral contraceptive (OC) cycle. The New York University Langone Medical Center Institutional Review Board approved this HIPAA-compliant prospective study. All participants provided written informed consent. Participants were aged 24-31 years.We measured several non-contrast breast MRI parameters during each week of a single menstrual cycle (among 9 women) and OC cycle (among 8 women). Hormones were measured to confirm ovulation and classify menstrual cycle phase among naturally cycling women and to monitor OC compliance among OC users. We investigated how the non-contrast MRI parameters of breast fibroglandular tissue (FGT), apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR), and transverse relaxation time (T2) varied over the natural and the OC cycles. We observed significant increases in MRI FGT% and ADC in FGT, and longer T2 in FGT in the luteal vs. follicular phase of the menstrual cycle. We did not observe any consistent pattern of change for any of the MRI parameters among women using OCs. MRI is sensitive to hormone-induced breast tissue changes during the menstrual cycle. Larger studies are needed to assess whether MRI is also sensitive to the effects of exogenous hormones, such as various OC formulations, on the breast tissue of young premenopausal women. Copyright © 2013 Elsevier Inc. All rights reserved.

77 FR 50724 - Developing Software Life Cycle Processes for Digital Computer Software Used in Safety Systems of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes for Digital... Software Life Cycle Processes for Digital Computer Software used in Safety Systems of Nuclear Power Plants... clarifications, the enhanced consensus practices for developing software life-cycle processes for digital...

Understanding bicycling in cities using system dynamics modelling.

PubMed

Macmillan, Alexandra; Woodcock, James

2017-12-01

Increasing urban bicycling has established net benefits for human and environmental health. Questions remain about which policies are needed and in what order, to achieve an increase in cycling while avoiding negative consequences. Novel ways of considering cycling policy are needed, bringing together expertise across policy, community and research to develop a shared understanding of the dynamically complex cycling system. In this paper we use a collaborative learning process to develop a dynamic causal model of urban cycling to develop consensus about the nature and order of policies needed in different cycling contexts to optimise outcomes. We used participatory system dynamics modelling to develop causal loop diagrams (CLDs) of cycling in three contrasting contexts: Auckland, London and Nijmegen. We combined qualitative interviews and workshops to develop the CLDs. We used the three CLDs to compare and contrast influences on cycling at different points on a "cycling trajectory" and drew out policy insights. The three CLDs consisted of feedback loops dynamically influencing cycling, with significant overlap between the three diagrams. Common reinforcing patterns emerged: growing numbers of people cycling lifts political will to improve the environment; cycling safety in numbers drives further growth; and more cycling can lead to normalisation across the population. By contrast, limits to growth varied as cycling increases. In Auckland and London, real and perceived danger was considered the main limit, with added barriers to normalisation in London. Cycling congestion and "market saturation" were important in the Netherlands. A generalisable, dynamic causal theory for urban cycling enables a more ordered set of policy recommendations for different cities on a cycling trajectory. Participation meant the collective knowledge of cycling stakeholders was represented and triangulated with research evidence. Extending this research to further cities, especially in low-middle income countries, would enhance generalizability of the CLDs.

Toward Optimal Cryopreservation and Storage for Achievement of High Cell Recovery and Maintenance of Cell Viability and T Cell Functionality.

PubMed

Angel, Stephanie; von Briesen, Hagen; Oh, Young-Joo; Baller, Marko K; Zimmermann, Heiko; Germann, Anja

2016-12-01

Cryopreservation of biological materials such as cells, tissues, and organs is a prevailing topic of high importance. It is employed not only in many research fields but also in the clinical area. Cryopreservation is of great importance for reproductive medicine and clinical studies, as well as for the development of vaccines. Peripheral blood mononuclear cells (PBMCs) are commonly used in vaccine research where comparable and reliable results between different research institutions and laboratories are of high importance. Whereas freezing and thawing processes are well studied, controlled, and standardized, storage conditions are often disregarded. To close this gap, we investigated the influence of suboptimal storage conditions during low-temperature storage on PBMC viability, recovery, and T cell functionality. For this purpose, PBMCs were isolated and exposed with help of a robotic system in a low-temperature environment from 0 up to 350 temperature fluctuation cycles in steps of 50 cycles to simulate storage conditions in large biorepositories with sample storage, removal, and sorting functions. After the simulation, the viability, recovery, and T cell functionality were analyzed to determine the number of temperature rises, which ultimately lead to significant cell damage. All studied parameters decreased with increasing number of temperature cycles. Sometimes after as little as only 50 temperature cycles, a significant effect was observed. These results are very important for all fields in which cell cryopreservation is employed, particularly for clinical and multicenter studies wherein the comparability and reproducibility of results play a crucial role. To obtain reliable results and to maintain the quality of the cells, not only the freezing and thawing processes but also the storage conditions should be controlled and standardized, and any deviations should be documented.

Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective study.

PubMed

Altwerger, Gary; Gressel, Gregory M; English, Diana P; Nelson, Wendelin K; Carusillo, Nina; Silasi, Dan-Arin; Azodi, Masoud; Santin, Alessandro; Schwartz, Peter E; Ratner, Elena S

2017-01-01

The carboplatin desensitization (CD) protocol presented here allows patients with either a positive skin test or a prior hypersensitivity reaction (HSR) to safely, rapidly and effectively continue with carboplatin infusions. Newly described factors can identify patients at risk for developing adverse events during CD. A retrospective review was performed on patients with gynecologic cancer who underwent CD between 2005 and 2014. The CD protocol uses a four-step dilution process over 3.5h. 129 patients underwent CD and completed a total of 788cycles. The desensitization protocol prevented HSRs in 96% (753 out of 788) of these cycles. Patients achieved an average of 6.1cycles (SD±4.55, range 0-23) with CD. The CD protocol allowed 73% (94 of 129) of the patients to undergo carboplatin infusion without reaction. Patients with moderate to life-threatening HSRs (grade 2 through 4) were 10.5years younger at initial CD than patients with grades 0 or 1 HSRs (52.3 vs. 63, P = 0.0307). One patient death occurred during her thirteenth desensitization cycle. The HSR in this case was complicated by pre-exisiting pulmonary hypertension. This is the largest study of its kind showing a safe, effective and rapid (3.5h) CD protocol. The majority of patients with a history of either carboplatin hypersensitivity reaction or a positive skin test completed the CD protocol without HSRs. Age was identified as a risk factor for HSR severity during CD. Age can be employed along with pre-load dependent cardiac conditions as a way to help risk stratify patients undergoing CD. Copyright © 2016 Elsevier Inc. All rights reserved.

Multidisciplinary life cycle metrics and tools for green buildings.

PubMed

Helgeson, Jennifer F; Lippiatt, Barbara C

2009-07-01

Building sector stakeholders need compelling metrics, tools, data, and case studies to support major investments in sustainable technologies. Proponents of green building widely claim that buildings integrating sustainable technologies are cost effective, but often these claims are based on incomplete, anecdotal evidence that is difficult to reproduce and defend. The claims suffer from 2 main weaknesses: 1) buildings on which claims are based are not necessarily "green" in a science-based, life cycle assessment (LCA) sense and 2) measures of cost effectiveness often are not based on standard methods for measuring economic worth. Yet, the building industry demands compelling metrics to justify sustainable building designs. The problem is hard to solve because, until now, neither methods nor robust data supporting defensible business cases were available. The US National Institute of Standards and Technology (NIST) Building and Fire Research Laboratory is beginning to address these needs by developing metrics and tools for assessing the life cycle economic and environmental performance of buildings. Economic performance is measured with the use of standard life cycle costing methods. Environmental performance is measured by LCA methods that assess the "carbon footprint" of buildings, as well as 11 other sustainability metrics, including fossil fuel depletion, smog formation, water use, habitat alteration, indoor air quality, and effects on human health. Carbon efficiency ratios and other eco-efficiency metrics are established to yield science-based measures of the relative worth, or "business cases," for green buildings. Here, the approach is illustrated through a realistic building case study focused on different heating, ventilation, air conditioning technology energy efficiency. Additionally, the evolution of the Building for Environmental and Economic Sustainability multidisciplinary team and future plans in this area are described.

A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma.

PubMed

Slomovitz, Brian M; Lu, Karen H; Johnston, Taren; Coleman, Robert L; Munsell, Mark; Broaddus, Russell R; Walker, Cheryl; Ramondetta, Lois M; Burke, Thomas W; Gershenson, David M; Wolf, Judith

2010-12-01

Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110α catalytic subunit of phosphatidylinositol-3-kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in constitutive activation of AKT, which leads to up-regulation of mammalian target of rapamycin (mTOR). Everolimus is an oral rapamycin analog that acts by selectively inhibiting mTOR. A single-institution, open-labeled, phase 2 study of everolimus in patients with measurable recurrent EC who had failed at least 1 and no more than 2 prior chemotherapeutic regimens was performed. Everolimus was administered at a dose of 10 mg orally daily for 28-day cycles. Patients were treated until disease progression or toxicity. The primary endpoint was clinical benefit response (CBR), defined as a confirmed complete or partial response or prolonged stable disease (SD) (≥8 weeks). Inclusion was limited to patients with endometrioid histology. A total of 35 patients were enrolled (median age, 58 years; range, 38-81 years). A total of 81 cycles were administered. Twelve of 28 (43%) evaluable patients had not developed disease progression at the time of the first objective evaluation (8 weeks). All these patients had SD (median, 4.5 cycles; range, 2-10 cycles). Six of the 28 (21%) patients had a confirmed CBR at 20 weeks of therapy. Patients with CBR discontinued treatment because of toxicity (6 patients), disease progression (5 patients), and noncompliance (1 patient). Seven patients were unevaluable after receiving ≤1 cycle because of toxicity (5 patients) or noncompliance (2 patients). The most common drug-related toxicities were fatigue, anemia, pain, lymphopenia, and nausea. Everolimus demonstrated encouraging single-agent CBR in pretreated patients with recurrent endometrioid EC. Future studies will evaluate this agent in combination with hormonal and/or cytotoxic therapy. Copyright © 2010 American Cancer Society.

Final Report Collaborative Project. Improving the Representation of Coastal and Estuarine Processes in Earth System Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryan, Frank; Dennis, John; MacCready, Parker

This project aimed to improve long term global climate simulations by resolving and enhancing the representation of the processes involved in the cycling of freshwater through estuaries and coastal regions. This was a collaborative multi-institution project consisting of physical oceanographers, climate model developers, and computational scientists. It specifically targeted the DOE objectives of advancing simulation and predictive capability of climate models through improvements in resolution and physical process representation. The main computational objectives were: 1. To develop computationally efficient, but physically based, parameterizations of estuary and continental shelf mixing processes for use in an Earth System Model (CESM). 2. Tomore » develop a two-way nested regional modeling framework in order to dynamically downscale the climate response of particular coastal ocean regions and to upscale the impact of the regional coastal processes to the global climate in an Earth System Model (CESM). 3. To develop computational infrastructure to enhance the efficiency of data transfer between specific sources and destinations, i.e., a point-to-point communication capability, (used in objective 1) within POP, the ocean component of CESM.« less

Teaching forensic medicine in the University of Porto.

PubMed

Magalhães, Teresa; Dinis-Oliveira, Ricardo Jorge; Santos, Agostinho

2014-07-01

The University of Porto (UP) provides education in Forensic Medicine (FM) through the 1st, 2nd and 3rd cycle of studies, post-graduation and continuing education courses. This education is related to forensic pathology, clinical forensic medicine (including forensic psychology and psychiatry), forensic chemistry and toxicology, forensic genetics and biology, and criminalistics. With this work we intent to reflect on how we are currently teaching FM in the UP, at all levels of university graduation. We will present our models, regarding the educational objectives, curricular program and teaching/learning methodologies of each cycle of studies as well as in post-graduate and continuing education courses. Historically, and besides related administratively to the Ministry of Justice, the Portuguese Medico-Legal Institutes (since 1918) and more recently the National Institute of Legal Medicine and Forensic Sciences (INMLCF) also have educational and research responsibilities. Thus, it lends space and cooperates with academic institutions and this contribution, namely regarding teaching forensic sciences in Portugal has been judged as an example for other Countries. This contribution is so important that in UP, the Department of Legal Medicine and Forensic Sciences of the Faculty of Medicine (FMUP) shares, until now, the same physical space with North Branch of the INMLCF, which represents a notorious advantage, since it makes possible the "learning by doing". Copyright © 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Building policy-making capacity in the Ministry of Health: the Kazakhstan experience.

PubMed

Chanturidze, Tata; Adams, Orvill; Tokezhanov, Bolat; Naylor, Mike; Richardson, Erica

2015-01-20

Recent economic growth in Kazakhstan has been accompanied by slower improvements in population health and this has renewed impetus for health system reform. Strengthening strategic planning and policy-making capacity in the Ministry of Health has been identified as an important priority, particularly as the Ministry of Health is leading the health system reform process. The intervention was informed by the United Nations Development Programme (UNDP) framework for capacity building which views capacity building as an ongoing process embedded in local institutions and practices. In response to local needs extra elements were included in the framework to tailor the capacity building programme according to the existing policy and budget cycles and respective competence requirements, and link it with transparent career development structures of the Ministry of Health. This aspect of the programme was informed by the institutional capability assessment model used by the United Kingdom National Health Service (NHS) which was adapted to examine the specific organizational and individual competences of the Ministry of Health in Kazakhstan. There were clear successes in building capacity for policy making and strategic planning within the Ministry of Health in Kazakhstan, including better planned, more timely and in-depth responses to policy assignments. Embedding career development as a part of this process was more challenging. This case study highlights the importance of strong political will and high level support for capacity building in ensuring the sustainability of programmes. It also shows that capacity-building programmes need to ensure full engagement with all local stakeholders, or where this is not possible, programmes need to be targeted narrowly to those stakeholders who will benefit most, for the greatest impact to be achieved. In sum, high quality tailor-made capacity development programmes should be based on thorough needs assessment of individual and organizational competences in a specific institutional setting. The experience showed that complementary approaches to human resource development worked effectively in the context of organizations and systems, where an enabling environment was present, and country ownership and political will was complemented by strong technical assistance to design and deliver high quality tailor-made capacity building initiatives.

MetNet - Martian Network Mission

NASA Astrophysics Data System (ADS)

Harri, A.-M.

2009-04-01

We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The actual practical mission development work started in January 2009 with participation from various countries and space agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2009/2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Detailed characterization of the Martian atmospheric circulation patterns, boundary layer phenomena, and climatology cycles, require simultaneous in-situ measurements by a network of observation posts on the Martian surface. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. Currently the INTA (Instituto Nacional de Técnica Aeroespacial) from Spain is also participating in the MetNet payload development.

4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study.

PubMed

Takase, Naoto; Matsumoto, Koji; Onoe, Takuma; Kitao, Akihito; Tanioka, Maki; Kikukawa, Yoshitaka; Yamaguchi, Satoshi; Fujiwara, Kiyoshi; Negoro, Shunichi

2015-06-01

Platinum agents are essential for treating gynecological malignancies, particularly ovarian cancer. However, multiple carboplatin doses may cause hypersensitivity reactions (HSRs). Carboplatin desensitization prevents life-threatening HSRs and promotes the successful completion of planned chemotherapy. Since January 2010, carboplatin desensitization was performed at our institution. Solutions with 1/1000, 1/100, and 1/10 dilutions of carboplatin and an undiluted solution were prepared in 250 mL of 5% glucose. Each solution was administered as a 1-h intravenous infusion (4-step 4-h protocol). This retrospective analysis was approved by the institutional review board. From January 2010 to December 2013, 20 patients with gynecological malignancies (median age 62 years, range 43-74 years) received desensitization treatment. The International Federation of Gynecology and Obstetrics stages at presentation were I, II, III, and IV in 1, 1, 15, 13 patients, respectively. During first-line and second-line treatments, 3 and 17 patients, respectively, experienced carboplatin-induced HSRs. The median carboplatin cycle number was 11 (range 2-16). In the first desensitization cycle, 17 (85%) patients completed treatment without adverse events, 2 experienced Grade 1 HSRs but completed treatment, and 1 experienced Grade 3 HSR and discontinued treatment. The first desensitization cycle completion rate was 95%. Of 83 desensitization cycles administered, 79 (95.2%) were completed. No treatment-related deaths occurred. Most patients completed the planned chemotherapy. Our protocol could be conducted safely with shorter duration and simpler procedures than previous protocols. Carboplatin desensitization seems beneficial for patients with a history of carboplatin-induced HSRs; however, the risk of HSR recurrence still remains. Desensitization should therefore be performed only by well-trained staff.

Characteristics of a liquid-helium-free calibration apparatus for cryogenic thermometers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shimazaki, T.

2013-09-11

Closed-cycle Joule-Thomson (JT) cryocoolers have been developed at National Metrology Institute of Japan (NMIJ)/National Institute of Advanced Industrial Science and Technology (AIST) with the aim of realizing a liquid-helium-free calibration apparatus for cryogenic thermometers between 0.65 K and 25 K. The latest JT cryocooler at NMIJ/AIST consists of a {sup 3}He JT cooling circuit and a pulse tube mechanical refrigerator. The characteristics of the apparatus including a residual gas analysis of the JT cooling circuit are presented in this paper. Currently the initial cool-down is performed using a heat-exchange gas. It normally takes about 30 h to reduce the temperaturemore » from room temperature to 5 K at the thermometer comparison block of the apparatus. The correct timing of the removal of the heatexchange gas is important for the efficient operation of the apparatus. Incomplete removal of the heat-exchange gas induces excess heat load on the apparatus and thermal disturbances. Some examples of abrupt temperature bursts are discussed in this paper. Mechanical refrigerators generate cyclic mechanical vibrations, and precision resistance thermometers are usually very sensitive to a mechanical vibration. The measured vibration level of the developed apparatus is reported. The damage to the apparatus due to the magnitude 9.0 earthquake on March 11, 2011, and possible countermeasures in the case of future earthquakes are also discussed.« less

Enhancement of environment and resources engineering studies through an international cooperation network

NASA Astrophysics Data System (ADS)

Caporali, E.; Tuneski, A.

2012-12-01

Higher education plays a very important role in the modern societies development, enhancing social, cultural and economic development for a sustainable growth, environment respectful. In this framework, the European Commission promotes the TEMPUS-Trans European Mobility Programme for University Studies. Curricula harmonization and lifelong learning programme development in higher education are among the focused aspects of the TEMPUS programme. The DEREL-Development of Environment and Resources Engineering Learning, is a three years TEMPUS project coordinated by the University of Firenze, in cooperation with colleagues of the Ss Cyril and Methodius University, Skopje financed and activated since October 2010. The DEREL Project Consortium consists of 4 EU Universities (from Italy, Greece, Germany and Austria), 7 Partner Countries (PC) Universities (from FYR of Macedonia, Serbia and Albania), and 1 PC Ministry, 4 PC National Agencies, 1 PC non governmental organization and 1 PC enterprise. In cooperation with the same 4 EU Universities and the same Macedonian Institutions, in the period 2005-2008 also a TEMPUS JEP entitled DEREC-Development of Environmental and Resources Engineering Curriculum, was also carried out by the University of Firenze in cooperation with colleagues of the Ss Cyril and Methodius University. Within DEREC a new three-years first cycle curriculum in Environmental and Resources Engineering was opened at the University Ss Cyril and Methodius, Skopje, and the necessary conditions for offering a Joint Degree Title, on the basis of an agreement between the Ss. Cyril and Methodius University and the University of Firenze, were fulfilled. The running DEREL project, as a continuation of DEREC, is aimed to introduce a new, up-to-date, postgraduate second cycle curriculum in Environment and Resources Engineering at the Ss Cyril and Methodius University in Skopje, FYR of Macedonia, University of Novi Sad, Serbia and Polytechnic University of Tirana, Albania, following the criteria and conditions for setting up a Joint Postgraduate Degree. The new second cycle degree courses are going to be activated in the academic year 2012/2012. Both the first and second cycle curricula, developed through the co-operation, exchange of know-how and expertise between partners, are based on the European Credit Transfer System and are in accordance with the Bologna Process. In DEREL a second objective is to implement a sustainable regional network aimed to offer lifelong learning seminars for environment and resources engineering education and training of interested stakeholders and organize workshops focused on strengthening the links in the knowledge triangle: environment education-innovation-research, with participation of postgraduate students, public services, enterprises and NGO's. Also, the good collaborative environment created, since 2005, with the project partners can be surely mentioned as an additional valuable objective of the two TEMPUS projects, enabling implementation of a sustainable international network for environment and resources engineering studies enhancement and development.

Cycling induced by functional electrical stimulation in children affected by cerebral palsy: case report.

PubMed

Trevisi, E; Gualdi, S; De Conti, C; Salghetti, A; Martinuzzi, A; Pedrocchi, A; Ferrante, S

2012-03-01

Recently, the efficacy of functional electrical stimulation (FES) cycling have been demonstrated on the improvement of strength and motor control in adults with stroke. FES-cycling, providing a repetitive goal-oriented task, could facilitate cortical reorganization and utilization of residual cortico-spinal pathways. These benefits could be more enhanced in children because of the greater plasticity and flexibility of their central nervous system. The aim of the present case report study was to explore the feasibility of FES-cycling in children with cerebral palsy (CP) and to provide a set of instrumental measures able to evaluate the effects of this novel treatment on cycling and walking ability. Interventional study. Two ambulant outpatient children with diplegic CP were recruited by the "E. Medea" Scientific Institute. Patients followed a FES-cycling treatment for 30 minutes a day, 3 days a week for 7 weeks. Pre and post treatment tests were performed, namely clinical measures and electromyographic, kinematic and oxygen expenditure analysis during gait and cycling. The treatment was safe, feasible and well accepted by the 2 children. After treatment both patients achieved a more symmetrical muscular strategy during voluntary cycling and gait and a significant reduction of muscle co-contractions during cycling. These improvements were corroborated by a decrease in oxygen expenditure during the post test for one of the two children, the less impaired, implying a better exploiting of bi-articular muscles. FES-cycling is feasible and safe and it may be an alternative rehabilitation method for diplegic CP patients. The set of instrumental measurements proposed seems to be a valuable tool for functional assessment to identify subclinical anomalies and improvements on cycling and gait in CP patients.

Analyzing the carbon cycle with the local ensemble transform Kalman filter, online transport model and real observation data

NASA Astrophysics Data System (ADS)

Maki, T.; Sekiyama, T. T.; Shibata, K.; Miyazaki, K.; Miyoshi, T.; Yamada, K.; Yokoo, Y.; Iwasaki, T.

2011-12-01

In the current carbon cycle analysis, inverse modeling plays an important role. However, it requires enormous computational resources when we deal with more flux regions and more observations. The local ensemble transform Kalman filter (LETKF) is an alternative approach to reduce such problems. We constructed a carbon cycle analysis system with the LETKF and MRI (Meteorological Research Institute) online transport model (MJ98-CDTM). In MJ98-CDTM, an off-line transport model (CDTM) is directly coupled with the MRI/JMA GCM (MJ98). We further improved vertical transport processes in MJ98-CDTM from previous study. The LETKF includes enhanced features such as smoother to assimilate future observations, adaptive inflation and bias correction scheme. In this study, we use CO2 observations of surface data (continuous and flask), aircraft data (CONTRAIL) and satellite data (GOSAT), although we plan to assimilate AIRS tropospheric CO2 data. We developed a quality control system. We estimated 3-day-mean CO2 flux at a resolution of T42. Here, only CO2 concentrations and fluxes are analyzed whereas meteorological fields are nudged by the Japanese reanalysis (JCDAS). The horizontal localization length scale and assimilation window are chosen to be 1000 km and 3 days, respectively. The results indicate that the assimilation system works properly, better than free transport model run when we validate with independent CO2 concentration observational data and CO2 analysis data.

Simulation and source identification of X-ray contrast media in the water cycle of Berlin.

PubMed

Knodel, J; Geissen, S-U; Broll, J; Dünnbier, U

2011-11-01

This article describes the development of a model to simulate the fate of iodinated X-ray contrast media (XRC) in the water cycle of the German capital, Berlin. It also handles data uncertainties concerning the different amounts and sources of input for XRC via source densities in single districts for the XRC usage by inhabitants, hospitals, and radiologists. As well, different degradation rates for the behavior of the adsorbable organic iodine (AOI) were investigated in single water compartments. The introduced model consists of mass balances and includes, in addition to naturally branched bodies of water, the water distribution network between waterways and wastewater treatment plants, which are coupled to natural surface waters at numerous points. Scenarios were calculated according to the data uncertainties that were statistically evaluated to identify the scenario with the highest agreement among the provided measurement data. The simulation of X-ray contrast media in the water cycle of Berlin showed that medical institutions have to be considered as point sources for congested urban areas due to their high levels of X-ray contrast media emission. The calculations identified hospitals, represented by their capacity (number of hospital beds), as the most relevant point sources, while the inhabitants served as important diffusive sources. Deployed for almost inert substances like contrast media, the model can be used for qualitative statements and, therefore, as a decision-support tool. Copyright © 2011 Elsevier Ltd. All rights reserved.

75 FR 10491 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel Medical Rehabilitation Research... Institute, of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, 301-435...

76 FR 40737 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Children's Research, Institute For... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...

Synchronized mammalian cell culture: part I--a physical strategy for synchronized cultivation under physiological conditions.

PubMed

Barradas, Oscar Platas; Jandt, Uwe; Becker, Max; Bahnemann, Janina; Pörtner, Ralf; Zeng, An-Ping

2015-01-01

Conventional analysis and optimization procedures of mammalian cell culture processes mostly treat the culture as a homogeneous population. Hence, the focus is on cell physiology and metabolism, cell line development, and process control strategy. Impact on cultivations caused by potential variations in cellular properties between different subpopulations, however, has not yet been evaluated systematically. One main cause for the formation of such subpopulations is the progress of all cells through the cell cycle. The interaction of potential cell cycle specific variations in the cell behavior with large-scale process conditions can be optimally determined by means of (partially) synchronized cultivations, with subsequent population resolved model analysis. Therefore, it is desirable to synchronize a culture with minimal perturbation, which is possible with different yield and quality using physical selection methods, but not with frequently used chemical or whole-culture methods. Conventional nonsynchronizing methods with subsequent cell-specific, for example, flow cytometric analysis, can only resolve cell-limited effects of the cell cycle. In this work, we demonstrate countercurrent-flow centrifugal elutriation as a useful physical method to enrich mammalian cell populations within different phases of a cell cycle, which can be further cultivated for synchronized growth in bioreactors under physiological conditions. The presented combined approach contrasts with other physical selection methods especially with respect to the achievable yield, which makes it suitable for bioreactor scale cultivations. As shown with two industrial cell lines (CHO-K1 and human AGE1.HN), synchronous inocula can be obtained with overall synchrony degrees of up to 82% in the G1 phase, 53% in the S phase and 60% in the G2/M phase, with enrichment factors (Ysync) of 1.71, 1.79, and 4.24 respectively. Cells are able to grow with synchrony in bioreactors over several cell cycles. This strategy, combined with population-resolved model analysis and parameter extraction as described in the accompanying paper, offers new possibilities for studies of cell lines and processes at levels of cell cycle and population under physiological conditions. © 2014 American Institute of Chemical Engineers.

The United Nations Human Space Technology Initiative

NASA Astrophysics Data System (ADS)

Balogh, Werner; Miyoshi, Takanori

2016-07-01

The United Nations Office for Outer Space Affairs (OOSA) launched the Human Space Technology Initiative (HSTI) in 2010 within the United Nations Programme on Space Applications, based on relevant recommendations of the Third United Nations Conference on the Exploration and Peaceful Uses of Outer Space (UNISPACE III). The activities of HSTI are characterized by the following "Three Pillars": International Cooperation, Outreach, and Capacity-building. For International Cooperation, OOSA and the Japan Aerospace Exploration Agency (JAXA) jointly launched a new programme entitled "KiboCUBE". KiboCUBE aims to provide educational or research institutions located in developing countries with opportunities to deploy cube satellites of their own design and manufacture from Japanese Experiment Module "Kibo" on-board the International Space Station (ISS). The Announcement of Opportunity was released on 8 September 2015 and the selected institution is to be announced by 1 August 2016. OOSA is also collaborating with WHO and with the COPUOS Expert Group on Space and Global Health to promote space technologies and ground- and space-based research activities that can contribute to improving global health. For Outreach, OOSA and the government of Costa Rica are jointly organising the United Nations/Costa Rica Workshop on Human Space Technology from 7 to 11 March 2016. Participants will exchange information on achievements in human space programmes and discuss how to promote international cooperation by further facilitating the participation of developing countries in human space exploration-related activities. Also, it will address the role of space industries in human space exploration and its related activities, considering that they have become significant stakeholders in this field. For Capacity-building, OOSA has been carrying out two activities: the Zero-Gravity Instrument Project (ZGIP) and the Drop Tower Experiment Series (DropTES). In ZGIP, OOSA has annually distributed clinostats (microgravity simulation instruments) worldwide. ZGIP has been providing students and teachers with the opportunity to study gravitational effects on samples such as plant seeds in a simulated microgravity condition. Currently, second and third cycles are on-going. DropTES is a fellowship programme, in which OOSA and the Centre of Applied Space Technology and Microgravity (ZARM) jointly provide one student team annually with the opportunity to conduct their own microgravity experiment at the Bremen Drop Tower, Germany. In 2015, in the DropTES second cycle, Universidad Católica Boliviana "San Pablo" was given the fellowship. DropTES has been extended to the third cycle for 2016.

Time-varying cycle average and daily variation in ambient air pollution and fecundability.

PubMed

Nobles, Carrie J; Schisterman, Enrique F; Ha, Sandie; Buck Louis, Germaine M; Sherman, Seth; Mendola, Pauline

2018-01-01

Does ambient air pollution affect fecundability? While cycle-average air pollution exposure was not associated with fecundability, we observed some associations for acute exposure around ovulation and implantation with fecundability. Ambient air pollution exposure has been associated with adverse pregnancy outcomes and decrements in semen quality. The LIFE study (2005-2009), a prospective time-to-pregnancy study, enrolled 501 couples who were followed for up to one year of attempting pregnancy. Average air pollutant exposure was assessed for the menstrual cycle before and during the proliferative phase of each observed cycle (n = 500 couples; n = 2360 cycles) and daily acute exposure was assessed for sensitive windows of each observed cycle (n = 440 couples; n = 1897 cycles). Discrete-time survival analysis modeled the association between fecundability and an interquartile range increase in each pollutant, adjusting for co-pollutants, site, age, race/ethnicity, parity, body mass index, smoking, income and education. Cycle-average air pollutant exposure was not associated with fecundability. In acute models, fecundability was diminished with exposure to ozone the day before ovulation and nitrogen oxides 8 days post ovulation (fecundability odds ratio [FOR] 0.83, 95% confidence interval [CI]: 0.72, 0.96 and FOR 0.84, 95% CI: 0.71, 0.99, respectively). However, particulate matter ≤10 microns 6 days post ovulation was associated with greater fecundability (FOR 1.25, 95% CI: 1.01, 1.54). Although our study was unlikely to be biased due to confounding, misclassification of air pollution exposure and the moderate study size may have limited our ability to detect an association between ambient air pollution and fecundability. While no associations were observed for cycle-average ambient air pollution exposure, consistent with past research in the United States, exposure during critical windows of hormonal variability was associated with prospectively measured couple fecundability, warranting further investigation. This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Longitudinal Investigation of Fertility and the Environment study contract nos. #N01-HD-3-3355, NO1-HD-#-3356, N01-HD-3-3358 and the Air Quality and Reproductive Health Study Contract No. HHSN275200800002I, Task Order No. HHSN27500008). We declare no conflict of interest. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Novel Supercritical Carbon Dioxide Power Cycle Utilizing Pressured Oxy-combustion in Conjunction with Cryogenic Compression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brun, Klaus; McClung, Aaron; Davis, John

2014-03-31

The team of Southwest Research Institute® (SwRI) and Thar Energy LLC (Thar) applied technology engineering and economic analysis to evaluate two advanced oxy-combustion power cycles, the Cryogenic Pressurized Oxy-combustion Cycle (CPOC), and the Supercritical Oxy-combustion Cycle. This assessment evaluated the performance and economic cost of the two proposed cycles with carbon capture, and included a technology gap analysis of the proposed technologies to determine the technology readiness level of the cycle and the cycle components. The results of the engineering and economic analysis and the technology gap analysis were used to identify the next steps along the technology development roadmapmore » for the selected cycle. The project objectives, as outlined in the FOA, were 90% CO{sub 2} removal at no more than a 35% increase in cost of electricity (COE) as compared to a Supercritical Pulverized Coal Plant without CO{sub 2} capture. The supercritical oxy-combustion power cycle with 99% carbon capture achieves a COE of $121/MWe. This revised COE represents a 21% reduction in cost as compared to supercritical steam with 90% carbon capture ($137/MWe). However, this represents a 49% increase in the COE over supercritical steam without carbon capture ($80.95/MWe), exceeding the 35% target. The supercritical oxy-combustion cycle with 99% carbon capture achieved a 37.9% HHV plant efficiency (39.3% LHV plant efficiency), when coupling a supercritical oxy-combustion thermal loop to an indirect supercritical CO{sub 2} (sCO{sub 2}) power block. In this configuration, the power block achieved 48% thermal efficiency for turbine inlet conditions of 650°C and 290 atm. Power block efficiencies near 60% are feasible with higher turbine inlet temperatures, however a design tradeoff to limit firing temperature to 650°C was made in order to use austenitic stainless steels for the high temperature pressure vessels and piping and to minimize the need for advanced turbomachinery features such as blade cooling. The overall technical readiness of the supercritical oxy-combustion cycle is TRL 2, Technology Concept, due to the maturity level of the supercritical oxy-combustor for solid fuels, and several critical supporting components, as identified in the Technical Gap Analysis. The supercritical oxycombustor for solid fuels operating at pressures near 100 atm is a unique component of the supercritical oxy-combustion cycle. In addition to the low TRL supercritical oxy-combustor, secondary systems were identified that would require adaptation for use with the supercritical oxycombustion cycle. These secondary systems include the high pressure pulverized coal feed, high temperature cyclone, removal of post-combustion particulates from the high pressure cyclone underflow stream, and micro-channel heat exchangers tolerant of particulate loading. Bench scale testing was utilized to measure coal combustion properties at elevated pressures in a CO{sub 2} environment. This testing included coal slurry preparation, visualization of coal injection into a high pressure fluid, and modification of existing test equipment to facilitate the combustion properties testing. Additional bench scale testing evaluated the effectiveness of a rotary atomizer for injecting a coal-water slurry into a fluid with similar densities, as opposed to the typical application where the high density fluid is injected into a low density fluid. The swirl type supercritical oxy-combustor was developed from initial concept to an advanced design stage through numerical simulation using FLUENT and Chemkin to model the flow through the combustor and provide initial assessment of the coal combustion reactions in the flow path. This effort enabled the initial combustor mechanical layout, initial pressure vessel design, and the conceptual layout of a pilot scale test loop. A pilot scale demonstration of the supercritical oxy-combustion cycle is proposed as the next step in the technology development. This demonstration would advance the supercritical oxy-combustion cycle and the supercritical oxy-combustor from a current TRL of 2, Technology Concept, to TRL 6, Pilot Scale System Demonstrated in a Relevant Environment, and enable the evaluation and continued refinement of the supercritical oxy-combustor and critical secondary systems.« less

Exploring the Influence of the Japanese Accreditation System through Managerial and Institutional Lenses

ERIC Educational Resources Information Center

Honda, Hirosuke

2012-01-01

In response to the declining quality of Japanese undergraduate education, the Ministry of Education implemented the accreditation system in 2004. As the first cycle of accreditation reviews ended in 2010, the effectiveness of these reviews has been discussed in the policy arena. This qualitative study examined the influence of accreditation…

Molecular mechanisms involved in the early steps of flavivirus cell entry.

PubMed

Kaufmann, Bärbel; Rossmann, Michael G

2011-01-01

Flaviviruses enter their host cells by receptor-mediated endocytosis, a well-orchestrated process of receptor recognition, penetration and uncoating. Recent findings on these early steps in the life cycle of flaviviruses are the focus of this review. Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

Carbon Emissions Trading and Combined Heat and Power Strategies: Unintended Consequences

ERIC Educational Resources Information Center

Tysseling, John C.; Vosevich, Mary; Boersma, Benjamin R.; Zumwalt, Jefferey A.

2009-01-01

Facility professionals continuously search for projects that reduce energy consumption and operating costs so as to directly benefit their bottom line. Many institutions nationwide have contemplated or made investments in combined heat and power (CHP) projects as a life-cycle strategy to minimize operating costs. However, recent sustainability and…

The Efficacy of Strategy in Higher Education--A Methodology. Professional File. Number 27

ERIC Educational Resources Information Center

Litwin, Jeffrey

2006-01-01

All research intensive universities (RIU's) want to expand their scope of operations. Research performance is a key driver of institutional reputation which underpins a university's ability to generate revenues from all sources. Achieving an accelerating rate of growth of the virtuous cycle, in which increasing research performance enhances…

77 FR 34395 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; Medication Adherence among Children with... Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the... cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.847, Diabetes, Endocrinology and...

Students' Perceptions of BIM Education in the Higher Education Sector: A UK and US Perspective

ERIC Educational Resources Information Center

Shelbourn, M.; Macdonald, J.; McCuen, T.; Lee, S.

2017-01-01

The use of building information modelling (BIM) has increased in the global architecture, engineering, construction and owner-operated (AECO) industries. This increased use has contributed to a recognition by project stakeholders of its importance across the building life cycle, leading higher education institutions to rethink their AECO…

Entrepreneurship and Small Business Course Outline.

ERIC Educational Resources Information Center

American Inst. of Small Business, Minneapolis, MN.

This course outline is intended as a guide to using the American Institute of Small Business' text entitled "How To Set Up Your Own Small Business." The outline, which is based on a 20- or 21-week course cycle, is organized around the following topics: the nature of small business and entrepreneurship; sources of information about entrepreneurship…

The Nurturing Parenting Programs. Family Strengthening Series. Juvenile Justice Bulletin.

ERIC Educational Resources Information Center

Bavolek, Stephen J.

This bulletin describes how parenting patterns are learned and how the Nurturing Parenting Programs, a group- and home-based intervention effort begun with the support of the National Institute of Mental Health, help stop generational cycles of abuse and neglect by building nurturing parenting skills. Section 1 examines the need for effective…

77 FR 5052 - Clad Steel Plate From Japan; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... Official, at (202) 205-3088. Limited disclosure of business proprietary information (BPI) under an... foreign trade or business association, or another interested party (including an explanation). If you are...

77 FR 71629 - Fresh Tomatoes From Mexico: Institution of a Five-Year Review Concerning the Suspended...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-03

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United... of business proprietary information (BPI) under an administrative protective order (APO) and APO... exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or another interested...

76 FR 74810 - Foundry Coke From China; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for..., Deputy Agency Ethics Official, at (202) 205-3088. Limited disclosure of business proprietary information... exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or another interested...

78 FR 39321 - Non-Malleable Cast Iron Pipe Fittings From China Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for... of business proprietary information (BPI) under an administrative protective order (APO) and APO... exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or another interested...

78 FR 19526 - Light-Walled Rectangular Pipe and Tube From China, Korea, Mexico, and Turkey; Institution of Five...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

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78 FR 60313 - Certain Lightweight Thermal Paper From China and Germany; Institution of Five-Year Reviews

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2013-10-01

... changes, if any, in the supply and demand conditions or business cycle for the Domestic Like Product that... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO... domestic producer, union/worker group, or trade/business association; import/export Subject Merchandise...

78 FR 65706 - Ferrovanadium From China and South Africa; Institution of Five-Year Reviews

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2013-11-01

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information... trade/business association; import/export Subject Merchandise from more than one Subject Country; or...

78 FR 46604 - Raw Flexible Magnets From China and Taiwan; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... changes, if any, in the supply and demand conditions or business cycle for the Domestic Like Product that... disclosure of business proprietary information (BPI) under an administrative protective order (APO) and APO.../worker group, or trade/business association; import/export Subject Merchandise from more than one Subject...

78 FR 33064 - Silicon Metal From Russia; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... significant changes, if any, in the supply and demand conditions or business cycle for the Domestic Like... of business proprietary information (BPI) under an administrative protective order (APO) and APO... producer or exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or...

78 FR 72114 - Circular Welded Carbon Quality Steel Line Pipe From China; Institution of Five-Year Reviews

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2013-12-02

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information..., a U.S. or foreign trade or business association, or another interested party (including an...

77 FR 25744 - Certain Polyester Staple Fiber From China; Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... changes, if any, in the supply and demand conditions or business cycle for the Domestic Like Product that... Official, at 202-205-3088. Limited disclosure of business proprietary information (BPI) under an... business association, or another interested party (including an explanation). If you are a union/worker...

76 FR 24516 - Artists' Canvas From China; Institution of a Five-Year Review Concerning the Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for... Official, at 202-205-3088. Limited disclosure of business proprietary information (BPI) under an... Subject Merchandise, a U.S. or foreign trade or business association, or another interested party...

78 FR 7452 - Sodium Hexametaphosphate From China: Institution of a Five-Year Review Concerning the Antidumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... significant changes, if any, in the supply and demand conditions or business cycle for the Domestic Like..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information..., a U.S. or foreign trade or business association, or another interested party (including an...

78 FR 39316 - Sodium Nitrite From China and Germany; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information.../worker group, or trade/business association; import/export Subject Merchandise from more than one Subject...

76 FR 11509 - Brass Sheet and Strip From France, Germany, Italy, and Japan

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... conditions or business cycle for the Domestic Like Product that have occurred in the United States or in the... of business proprietary information (BPI) under an administrative protective order (APO) and APO... to This Notice of Institution: If you are a domestic producer, union/worker group, or trade/business...

78 FR 72116 - Diamond Sawblades and Parts Thereof From China Institution of a Five-Year Review.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for... of business proprietary information (BPI) under an administrative protective order (APO) and APO... trade or business association, or another interested party (including an explanation). If you are a...

78 FR 33108 - Circular Welded Carbon-Quality Steel Pipe From China; Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information... Subject Merchandise, a U.S. or foreign trade or business association, or another interested party...

78 FR 46607 - Certain Off-The-Road Tires From China Institution of Five-Year Reviews

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information..., a U.S. or foreign trade or business association, or another interested party [[Page 46609...

77 FR 59970 - Silicomanganese From India, Kazakhstan, and Venezuela; Institution of Five-Year Reviews...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... and demand conditions or business cycle for the Domestic Like Product that have occurred in the United... Carol McCue Verratti, Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business.../worker group, or trade/business association; import/export Subject Merchandise from more than one Subject...

76 FR 54487 - Fresh Garlic From China; Institution of a Five-Year Review Concerning the Antidumping Duty Order...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for.... Limited disclosure of business proprietary information (BPI) under an administrative protective order (APO... trade or business association, or another interested party (including an explanation). If you are a...

12 CFR 615.5260 - Retirement of eligible borrower stock.

Code of Federal Regulations, 2010 CFR

2010-01-01

... course of business means: (i) Retirement upon repayment of a loan or under a retirement or revolvement... surplus subject to retirement under a revolving cycle and retired out or order pursuant to §§ 615.5280 and... institution retires eligible borrower stock in the ordinary course of business, such equities shall be retired...

Business Cycles and Postsecondary School Enrollment

ERIC Educational Resources Information Center

Samitamana, Ravi

2009-01-01

Human capital theory suggests that the opportunity cost is lower during an economic recession which in turn encourages a person to enroll in a postsecondary educational institution. At the same time, the ability to pay the direct costs of education is reduced. The two effects work in an opposite direction. Using unemployment rates as a business…

76 FR 45853 - Certain Bearings From China, France, Germany, and Italy; Institution of Five-Year Reviews...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... changes, if any, in the supply and demand conditions or business cycle for the Domestic Like Products that..., Deputy Agency Ethics Official, at 202-205-3088. Limited disclosure of business proprietary information.../worker group, or trade/business association; import/export Subject Merchandise from more than one Subject...

78 FR 65709 - Crawfish Tail Meat From China Institution of a Five-Year Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

.... (12) Identify significant changes, if any, in the supply and demand conditions or business cycle for.... Limited disclosure of business proprietary information (BPI) under an administrative protective order (APO... producer or exporter of the Subject Merchandise, a U.S. or foreign trade or business association, or...

Third Culture Kids and College Support: A Case Study

ERIC Educational Resources Information Center

Holdren, Sarah Jennifer

2013-01-01

This single site case study applies the "Transition Cycle" framework (Pollock & Van Reken, 2009) to an institutionally-based, student-run support program for Third Culture Kids. The purpose of this study was to examine how Lewis and Clark College responded to the presence of Third Culture Kid, or Global Nomad, students on campus by…

75 FR 1362 - Medical Area Total Energy Plant, Inc., New MATEP Inc.; Notice of Application for Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... cogeneration and combined cycle modes, currently comprised of combustion turbine, diesel and steam turbine... natural gas and oil based fuels. The facility is interconnected with NSTAR Electric Company, and sells excess electric power output that is not consumed by the facility's institutional and commercial...

Rock Cycle Sagas: The STRATegy COLUMN for Precollege Science Teachers.

ERIC Educational Resources Information Center

Metzger, Ellen Pletcher

1994-01-01

Reviews The Best of BAESI: Earth Science Activities & Recommended Resources from the Bay Area Earth Science Institute. The Best of BAESI is divided into two parts. Part I contains 19 classroom activities on topographic maps, rocks and minerals, earthquakes, volcanoes, and plate tectonics. Part II describes resources and identifies government…

Overview of the Turbine Based Combined Cycle Discipline

NASA Technical Reports Server (NTRS)

Thomas, Scott R.; Walker, James F.; Pittman, James L.

2009-01-01

The NASA Fundamental Aeronautics Hypersonics project is focused on technologies for combined cycle, airbreathing propulsions systems to enable reusable launch systems for access to space. Turbine Based Combined Cycle (TBCC) propulsion systems offer specific impulse (Isp) improvements over rocket-based propulsion systems in the subsonic takeoff and return mission segments and offer improved safety. The potential to realize more aircraft-like operations with expanded launch site capability and reduced system maintenance are additional benefits. The most critical TBCC enabling technologies as identified in the National Aeronautics Institute (NAI) study were: 1) mode transition from the low speed propulsion system to the high speed propulsion system, 2) high Mach turbine engine development, 3) transonic aero-propulsion performance, 4) low-Mach-number dual-mode scramjet operation, 5) innovative 3-D flowpath concepts and 6) innovative turbine based combined cycle integration. To address several of these key TBCC challenges, NASA s Hypersonics project (TBCC Discipline) initiated an experimental mode transition task that includes an analytic research endeavor to assess the state-of-the-art of propulsion system performance and design codes. This initiative includes inlet fluid and turbine performance codes and engineering-level algorithms. This effort has been focused on the Combined Cycle Engine Large-Scale Inlet Mode Transition Experiment (CCE LIMX) which is a fully integrated TBCC propulsion system with flow path sizing consistent with previous NASA and DoD proposed Hypersonic experimental flight test plans. This experiment is being tested in the NASA-GRC 10 x 10 Supersonic Wind Tunnel (SWT) Facility. The goal of this activity is to address key hypersonic combined-cycle-engine issues: (1) dual integrated inlet operability and performance issues unstart constraints, distortion constraints, bleed requirements, controls, and operability margins, (2) mode-transition constraints imposed by the turbine and the ramjet/scramjet flow paths (imposed variable geometry requirements), (3) turbine engine transients (and associated time scales) during transition, (4) high-altitude turbine engine re-light, and (5) the operating constraints of a Mach 3-7 combustor (specific to the TBCC). The model will be tested in several test phases to develop a unique TBCC database to assess and validate design and analysis tools and address operability, integration, and interaction issues for this class of advanced propulsion systems. The test article and all support equipment is complete and available at the facility. The test article installation and facility build-up in preparation for the inlet performance and operability characterization is near completion and testing is planned to commence in FY11.

Study of menstrual patterns in adolescent girls with disabilities in a residential institution.

PubMed

Joshi, Ganesh Arun; Joshi, Prajakta Ganesh

2015-02-01

The gynecological health needs of girls with disabilities is an issue related to their rights as individuals. The objective of this study is to describe the menstrual pattern of girls with disabilities. A descriptive study was undertaken on thirty girls with different types of disabilities in a residential institution. The diagnosis, type of disability, secondary sexual characters, age at menarche, menstrual pattern and practice of menstrual hygiene was noted. The girls with intellectual disabilities had later age of menarche, irregular cycles and more behaviour problems. The girls with hearing impairment and locomotor disabilities had normal menstrual pattern. The girl with low vision had earlier menarche and regularized cycles. Girls with normal intelligence and mild intellectual disabilities were independent in maintaining menstrual hygiene. The menstrual disorders are managed conservatively in accordance with latest guidelines. Onset of menarche is towards the extremes of normal age range in girls with intellectual disabilities or visual impairment but not in girls with hearing impairments or locomotor disabilities. Girls with disabilities have potential for independent menstrual care. Menstrual disorders were managed conservatively.

Solar fuels production as a sustainable alternative for substituting fossil fuels: COSOLπ project

NASA Astrophysics Data System (ADS)

Hernando Romero-Paredes, R.; Alvarado-Gil, Juan José; Arancibia-Bulnes, Camilo Alberto; Ramos-Sánchez, Víctor Hugo; Villafán-Vidales, Heidi Isabel; Espinosa-Paredes, Gilberto; Abanades, Stéphane

2017-06-01

This article presents, in summary form, the characteristics of COSOLπ development project and some of the results obtained to date. The benefits of the work of this project will include the generation of a not polluting transportable energy feedstock from a free, abundant and available primary energy source, in an efficient method with no greenhouse gas emission. This will help to ensure energy surety to a future transportation/energy infrastructure, without any fuel import. Further technological development of thermochemical production of clean fuels, together with solar reactors and also with the possibility of determining the optical and thermal properties of the materials involved a milestone in the search for new processes for industrialization. With the above in mind, important national academic institutions: UAM, UNAM, CINVESTAV, UACH, UNISON among others, have been promoting research in solar energy technologies. The Goals and objectives are to conduct research and technological development driving high-temperature thermochemical processes using concentrated solar radiation as thermal energy source for the future sustainable development of industrial processes. It focuses on the production of clean fuels such as H2, syngas, biofuels, without excluding the re-value of materials used in the industry. This project conducts theoretical and experimental studies for the identification, characterization, and optimization of the most promising thermochemical cycles, and for the thorough investigation of the reactive chemical systems. It applies material science and nano-engineering to improve chemicals properties and stability upon cycling. The characterization of materials will serve to measure the chemical composition and purity (MOX fraction-1) of each of the samples. The characterizations also focus on the solid particle morphology (shape, size, state of aggregation, homogeneity, specific surface) images obtained from SEM / TEM and BET measurements. Likewise will the thermal and optical characterization of the influence that these parameters represent in the solar reactor. The experimental and theoretical results obtained for each redox system will be compared and analyzed to determine the cycle with the highest potential. Advances on simulation, design, construction and experimentation on solar reactors to conduct thermochemical splitting water reactions are presented.

Thermal and nuclear power plants: Competitiveness in the new economic conditions

NASA Astrophysics Data System (ADS)

Aminov, R. Z.; Shkret, A. F.; Garievskii, M. V.

2017-05-01

In recent years, the conditions of development and functionality of power generating assets have notably changed. Considering the decline in the price of hydrocarbon fuel on the global market, the efficiency of combined-cycle gas-turbine plants in the European part of Russia is growing in comparison with nuclear power plants. Capital investments in the construction of nuclear power plants have also increased as a result of stiffening the safety requirements. In view of this, there has been an increasing interest in exploration of effective lines of development of generating assets in the European part of Russia, taking consideration of the conditions that may arise in the nearest long-term perspective. In particular, the assessment of comparative efficiency of developing combined-cycle gas-turbine plants (operating on natural gas) in the European part of Russia and nuclear power plants is of academic and practical interest. In this article, we analyze the trends of changes in the regional price of hydrocarbon fuel. Using the prognosis of net-weighted import prices of natural gas in Western European countries—prepared by the International Energy Agency (IEA) and the Energy Research Institute of the Russian Academy of Sciences (ERIRAS)—the prices of natural gas in the European part of Russia equilibrated with import prices of this heat carrier in Western Europe were determined. The methodology of determining the comparative efficiency of combined-cycle gas turbine plants (CCGT) and nuclear power plants (NPP) were described; based on this, the possible development of basic CCGTs and NPPs with regard to the European part of Russia for various scenarios in the prognosis of prices of gaseous fuel in a broad range of change of specific investments in the given generating sources were assessed, and the extents of their comparative efficiency were shown. It was proven that, at specific investments in the construction of new NPPs in the amount of 5000 dollars/kW, nuclear power plants in the European part of Russia become less efficient as compared to CCGTs operating on natural gas.

Observations of a cycle of intense coastal upwelling and downwelling at the research site of the Shirshov Institute of Oceanology in the Black Sea

NASA Astrophysics Data System (ADS)

Zatsepin, A. G.; Silvestrova, K. P.; Kuklev, S. B.; Piotoukh, V. B.; Podymov, O. I.

2016-03-01

The paper presents the results of joint analysis of the response of vertical temperature and current velocity profile distributions in the coastal zone of the Gelendzhik region of the Black Sea to strong wind forcing in the third ten-day period of September 2013. This forcing was caused by the propagation of an atmospheric cyclone, which first initiated coastal upwelling that was later replaced by downwelling. We formulate a criterion for the development of full coastal upwelling and demonstrate its efficiency. We assume that frequent events of incomplete coastal upwelling and downwelling are associated with changes in the water dynamics (variations in the intensity and direction of the alongshore current) generally not related to local wind forcing.

The sea as science: ocean research institutions and strategies in Portugal in the twentieth century (from the First Republic to democracy).

PubMed

Rollo, Maria Fernanda; Queiroz, Maria Inês; Brandão, Tiago

2014-01-01

Historical perspective has revealed the many aspects of Portugal's interest in the sea, evident in a series of initiatives and entities throughout the twentieth century. From the beginning of the century until the 1974 Revolution, the genesis of organizations devoted to the scientific study of the sea is analyzed, observing their specific missions in the context of the formulation of science policy, and more specifically "ocean policies." The Portuguese valued knowledge of the sea due to their maritime vocation, coastal life and geographic position. Traversing different historical and political contexts and development cycles, the assumptions and political implications that accentuate the strategic dimension of science policy, visible in the geopolitical affirmation of oceanography, are studied.

The most frequently cited adsorption research articles in the Science Citation Index (Expanded).

PubMed

Fu, Hui-Zhen; Wang, Ming-Huang; Ho, Yuh-Shan

2012-08-01

The 126 most frequently cited articles published in the adsorption field between 1900 and 2011 were identified and characterized using the Science Citation Index (Expanded). The data analyzed cover a range of publication years, journals, Web of Science categories, authors, institutions, countries/territories, life citation cycle curves, and characteristics of frequently cited articles. The 126 most-frequently-cited articles were each cited an average of 1014 times, ranging from 502 to 9922 citations per article from 1918 to 2006; 80% of these articles were published after 1970. Fifty-five journals were represented, led by the Journal of the American Chemical Society, and followed by Science and Nature. Three categories out of the 35 Web of Science categories constituted 60% of the citations. The three categories were: physical chemistry, multidisciplinary chemistry, and multidisciplinary sciences. Thirteen of the authors contributed three or more articles. Harvard University, the Massachusetts Institute of Technology, and the University of Washington led the list of 107 institutions, while the United States led the list of 17 countries/territories, comprising more than half of the articles. Collaboration among the top authors was a frequent occurrence, while inter-institutional collaboration and national collaboration was not obvious among the topmost articles. Moreover, the citation patterns as a function of time varied widely among the topmost articles. As evidenced by citation life cycles, the well known BET and Langmuir isotherms have received considerable attention during the study period, and will probably continue to be popular in the adsorption field. Some emerging hotspots are likely to receive particular attention in the near future; these include the new family of "M41S" materials, pseudo-second-order kinetic models, and the nudged elastic band method. Copyright © 2012 Elsevier Inc. All rights reserved.

Effects of over-the-counter analgesic use on reproductive hormones and ovulation in healthy, premenopausal women

PubMed Central

Matyas, R.A.; Mumford, S.L.; Schliep, K.C.; Ahrens, K.A.; Sjaarda, L.A.; Perkins, N.J.; Filiberto, A.C.; Mattison, D.; Zarek, S.M.; Wactawski-Wende, J.; Schisterman, E.F.

2015-01-01

STUDY QUESTION Does use of commonly used over-the-counter (OTC) pain medication affect reproductive hormones and ovulatory function in premenopausal women? SUMMARY ANSWER Few associations were found between analgesic medication use and reproductive hormones, but use during the follicular phase was associated with decreased odds of sporadic anovulation after adjusting for potential confounders. WHAT IS KNOWN ALREADY Analgesic medications are the most commonly used OTC drugs among women, but their potential effects on reproductive function are unclear. STUDY DESIGN, SIZE, DURATION The BioCycle Study was a prospective, observational cohort study (2005–2007) which followed 259 women for one (n = 9) or two (n = 250) menstrual cycles. PARTICIPANTS, SETTING, METHODS Two hundred and fifty-nine healthy, premenopausal women not using hormonal contraception and living in western New York state. Study visits took place at the University at Buffalo. MAIN RESULTS AND THE ROLE OF CHANCE During study participation, 68% (n = 175) of women indicated OTC analgesic use. Among users, 45% used ibuprofen, 33% acetaminophen, 10% aspirin and 10% naproxen. Analgesic use during the follicular phase was associated with decreased odds of sporadic anovulation after adjusting for age, race, body mass index, perceived stress level and alcohol consumption (OR 0.36 [0.17, 0.75]). Results remained unchanged after controlling for potential confounding by indication by adjusting for ‘healthy’ cycle indicators such as amount of blood loss and menstrual pain during the preceding menstruation. Moreover, luteal progesterone was higher (% difference = 14.0, −1.6–32.1, P = 0.08 adjusted) in cycles with follicular phase analgesic use, but no associations were observed with estradiol, LH or FSH. LIMITATIONS, REASONS FOR CAUTION Self-report daily diaries are not validated measures of medication usage, which could lead to some classification error of medication use. We were also limited in our evaluation of aspirin and naproxen which were used by few women. WIDER IMPLICATIONS OF THE FINDINGS The observed associations between follicular phase analgesic use and higher progesterone and a lower probability of sporadic anovulation indicate that OTC pain medication use is likely not harmful to reproduction function, and certain medications possibly improve ovulatory function. STUDY FUNDING/COMPETING INTERESTS This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract # HHSN275200403394C). The authors have no conflicts of interest to disclose. PMID:25954035

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Integrated Electrochemical Processes for CO 2 Capture and Conversion to Commodity Chemicals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hatton, T. Alan; Jamison, Timothy

2013-09-30

The Massachusetts Institute of Technology (MIT) and Siemens Corporations (SCR) are developing new chemical synthesis processes for commodity chemicals from CO 2. The process is assessed as a novel chemical sequestration technology that utilizes CO 2 from dilute gas streams generated at industrial carbon emitters as a raw material to produce useful commodity chemicals. Work at Massachusetts Institute of Technology (MIT) commenced on October 1st, 2010, and finished on September 30th, 2013. During this period, we have investigated and accomplished five objectives that mainly focused on converting CO 2 into high-value chemicals: 1) Electrochemical assessment of catalytic transformation of COmore » 2 and epoxides to cyclic carbonates; 2) Investigation of organocatalytic routes to convert CO 2 and epoxide to cyclic carbonates; 3) Investigation of CO 2 Capture and conversion using simple olefins under continuous flow; 4) Microwave assisted synthesis of cyclic carbonates from olefins using sodium bicarbonates in a green pathway; 5) Life cycle analyses of integrated chemical sequestration process. In this final report, we will describe the detailed study performed during the three year period and findings and conclusions drawn from our research.« less

The highly-cited Electrocardiogram-related articles in science citation index expanded: characteristics and hotspots.

PubMed

Yang, Xianglin; Gu, Jiaojiao; Yan, Hong; Xu, Zhi; Ren, Bing; Yang, Yaming; Yang, Xiaodong; Chen, Qi; Tan, Shaohua

2014-01-01

We used bibliometric analysis methodology in the expanded Science Citation Index to identify highly-cited electrocardiogram (ECG)-related articles with total citations (TC2012) exceeding 100 from the publication year to 2012. Web of Science search tools were used to identify the highly-cited articles. The aspects analyzed for highly cited publications included effect of time on citation analysis, journals and Web of Science categories, number of authors per publication, originating institutions and countries, total citation and total citation per year life cycles of articles (C2012) and research hotspots. Results showed that a total of 467 electrocardiogram-related publications were regarded as the highly-cited publications. TC2012 ranged from 101 to 2879, with 215 as the average number of citations. No highly-cited publications have emerged yet during the first two years of the present 2010 Decade. All 11 countries and institutions originating highly-cited ECG-related publications were developed countries, USA in 9 of them. Four subject categories were identified as hotspots by total citations TC2012 and C2012: atrial fibrillation, long QT syndrome, angina and myocardial infarction, and risk factor analysis and health evaluation. Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical networks with inflows and outflows: a positive linear differential inclusions approach.

PubMed

Angeli, David; De Leenheer, Patrick; Sontag, Eduardo D

2009-01-01

Certain mass-action kinetics models of biochemical reaction networks, although described by nonlinear differential equations, may be partially viewed as state-dependent linear time-varying systems, which in turn may be modeled by convex compact valued positive linear differential inclusions. A result is provided on asymptotic stability of such inclusions, and applied to a ubiquitous biochemical reaction network with inflows and outflows, known as the futile cycle. We also provide a characterization of exponential stability of general homogeneous switched systems which is not only of interest in itself, but also plays a role in the analysis of the futile cycle. 2009 American Institute of Chemical Engineers

Turning points and advanced family cycles: aging effect in Mexican homes*

PubMed Central

Montes de Oca, Verónica; Hebrero, Mirna

2017-01-01

Aging in Mexico is a process with several effects in the families and homes. However, the presence of older members in Mexican families has been scarcely analyzed. In this paper we reflect on the experiences of homes with advanced life cycles when turning points happen, such as widowhood, retirement, empty nest stage and when chronic diseases appear, as well as caring processes and family and social networks weakening, and social and institutional support diminution. We analyze some data from the National Survey on Health and Aging in Mexico (Enasem, 2001) considering the gender differences and, specially, health condition of elder people. PMID:29391856

Overview of the Earth System Science Education Alliance Online Courses

NASA Astrophysics Data System (ADS)

Botti, J. A.

2001-12-01

Science education reform has skyrocketed over the last decade in large part thanks to technology-and one technology in particular, the Internet. The World Wide Web has opened up dynamic new online communities of learners. It has allowed educators from around the world to share thoughts about Earth system science and reexamine the way science is taught. A positive offshoot of this reform effort is the Earth System Science Education Alliance (ESSEA). This partnership among universities, colleges, and science education organizations is led by the Institute for Global Environmental Strategies and the Center for Educational TechnologiesTM at Wheeling Jesuit University. ESSEA's mission is to improve Earth system science education. ESSEA has developed three Earth system science courses for K-12 teachers. These online courses guide teachers into collaborative, student-centered science education experiences. Not only do these courses support teachers' professional development, they also help teachers implement Earth systems science content and age-appropriate pedagogical methods into their classrooms. The ESSEA courses are open to elementary, middle school, and high school teachers. Each course lasts one semester. The courses begin with three weeks of introductory content. Then teachers develop content and pedagogical and technological knowledge in four three-week learning cycles. The elementary school course focuses on basic Earth system interactions between land, life, air, and water. In week A of each learning cycle, teachers do earth system activities with their students. In week B teachers investigate aspects of the Earth system -- for instance, the reason rocks change to soil, the relationship between rock weathering and soil nutrients, and the consequent development of biomes. In week C teachers develop classroom activities and share them online with other course participants. The middle school course stresses the effects of real-world events -- volcanic eruptions, hurricanes, rainforest destruction -- on Earth's lithosphere, atmosphere, biosphere, and hydrosphere. Teachers team during week A of each cycle to research the effect of each event on individual spheres. In week B groups "jigsaw" to study the interactions between events, spheres, and positive and negative feedback loops. In week C teachers develop classroom activities. The high school course uses problem-based learning to examine critical areas of global change, such as coral reef degradation, ozone depletion, and climate change. The ESSEA presentation provides examples of learning environments from each of the three courses.

Overview of the Earth System Science Education Alliance Online Courses

NASA Astrophysics Data System (ADS)

Botti, J.; Myers, R.

2002-12-01

Science education reform has skyrocketed over the last decade in large part thanks to technology-and one technology in particular, the Internet. The World Wide Web has opened up dynamic new online communities of learners. It has allowed educators from around the world to share thoughts about Earth system science and reexamine the way science is taught. A positive offshoot of this reform effort is the Earth System Science Education Alliance (ESSEA). This partnership among universities, colleges, and science education organizations is led by the Institute for Global Environmental Strategies and the Center for Educational Technologiestm at Wheeling Jesuit University. ESSEA's mission is to improve Earth system science education. ESSEA has developed three Earth system science courses for K-12 teachers. These online courses guide teachers into collaborative, student-centered science education experiences. Not only do these courses support teachers' professional development, they also help teachers implement Earth systems science content and age-appropriate pedagogical methods into their classrooms. The ESSEA courses are open to elementary, middle school, and high school teachers. Each course lasts one semester. The courses begin with three weeks of introductory content. Then teachers develop content and pedagogical and technological knowledge in four three-week learning cycles. The elementary school course focuses on basic Earth system interactions between land, life, air, and water. In week A of each learning cycle, teachers do earth system activities with their students. In week B teachers investigate aspects of the Earth system-for instance, the reason rocks change to soil, the relationship between rock weathering and soil nutrients, and the consequent development of biomes. In week C teachers develop classroom activities and share them online with other course participants. The middle school course stresses the effects of real-world events-volcanic eruptions, hurricanes, rainforest destruction-on Earth's lithosphere, atmosphere, biosphere, and hydrosphere. Teachers team during week A of each cycle to research the effect of each event on individual spheres. In week B groups "jigsaw" to study the interactions between events, spheres, and positive and negative feedback loops. In week C teachers develop classroom activities. The high school course uses problem-based learning to examine critical areas of global change, such as coral reef degradation, ozone depletion, and climate change. The ESSEA presentation provides examples of learning environments from each of the three courses.

Prognostic factors for patients undergoing vitrified-warmed human embryo transfer cycles: a retrospective cohort study.

PubMed

Takahashi, Toshifumi; Hasegawa, Ayumi; Igarashi, Hideki; Amita, Mitsuyoshi; Matsukawa, Jun; Takehara, Isao; Suzuki, Satoko; Nagase, Satoru

2017-06-01

We examined the prognostic factors for pregnancy in 210 vitrified-warmed embryo transfer (ET) cycles in 121 patients. The univariate analysis showed that age, gravida, the number of cycles associated with infertility caused by endometriosis, the number of previous assisted reproductive technology (ART) treatment cycles, and the number of ICSI procedures were significantly lower in pregnant cycles compared with non-pregnant cycles. The percentages of ET using at least one intact embryo and of ET using at least one embryo that had developed further after warming were significantly higher in pregnant cycles compared with non-pregnant cycles. Multivariate logistic regression analysis showed that previous ART treatment cycles, ET with at least one intact embryo, and ET using at least one embryo that had developed further were independent prognostic factors for pregnancy in vitrified-warmed ET cycles. We conclude that fewer previous ART treatment cycles, ET using at least one intact embryo, and ET with embryos that have developed further after warming might be favourable prognostic factors for pregnancy in vitrified-warmed ET cycles.

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Large-scale water resources management within the framework of GLOWA-Danube. Part A: The groundwater model

NASA Astrophysics Data System (ADS)

Barthel, Roland; Rojanschi, Vlad; Wolf, Jens; Braun, Juergen

The research project GLOWA-Danube, financed by the German Federal Government, is investigating long-term changes in the water cycle of the upper Danube river basin (77,000 km 2) in light of global climatic change. Its aim is to build a fully integrated decision-support tool “DANUBIA” that combines the competence of 11 different research institutes in domains covering all major aspects governing the water cycle-from the formation of clouds, to groundwater flow patterns, to the behaviour of the water consumer. Both the influence of natural changes in the ecosystem, such as climate change, and changes in human behaviour, such as changes in land use or water consumption, are considered. DANUBIA is comprised of 15 individual disciplinary models that are connected via customized interfaces that facilitate network-based parallel calculations. The strictly object-oriented DANUBIA architecture was developed using the graphical notation tool UML (Unified Modeling Language) and has been implemented in Java code. All models use the same spatial discretisation for the exchange of data (1 × 1 km grid cells) but are using different time steps. The representation of a vast number of relevant physical and social processes that occur at different spatial and temporal scales is a very demanding task. Newly developed up- and downscaling procedures [Rojanschi, V., 2001. Effects of upscaling for a finite-difference flow model. Master’s Thesis, Institut für Wasserbau, Universität Stuttgart, Stuttgart, Germany] and a sophisticated time controller developed by the computer sciences group [Hennicker, R., Barth, M., Kraus, A., Ludwig, M., 2002. DANUBIA: A Web-based modelling and decision support system for integrative global change research in the upper Danube basin. In: GSF (Ed.), GLOWA, German Program on Global Change in the Hydrological Cycle Status Report 2002. GSF, Munich, pp. 35-38; Kraus, A., Ludwig, M., 2003. GLOWA-Danube Papers Technical Release No. 002 (Danubia Framework), Software-Release No.: 0.9.2, Documentation Version: 0.10, Release Date: 27 March 2003] are required to solve the emerging problems. After a first successful public demonstration of the DANUBIA package (nine models) in May 2002 [Mauser, W., Stolz, R., Colgan, A., 2002. GLOWA-Danube: integrative techniques, scenarios and strategies regarding global change of the water cycle. In: GSF (Ed.), GLOWA, German Program on Global Change in the Hydrological Cycle (Phase I, 2000-2003) Status Report 2002. GSF, Munich, pp. 31-34], the research consortium is now preparing a first validation run of DANUBIA for the period 1995-1999 with all 15 models. After successful completion of the validation, a scenario run based on IPCC climate scenarios [IPCC, 2001. Climate Change 2001: Synthesis Report. In: Watson, R.T., Core Writing Team (Eds.), A Contribution of Working Groups I, II, and III to the Third Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge University Press, Cambridge, UK and New York, NY, USA, 398pp] for a five year period between 2025 and 2040 will follow at the end of 2003. The research group “Groundwater and Water Resources Management” at the Institute of Hydraulic Engineering, Universität Stuttgart, is contributing both a three-dimensional groundwater flow model of the catchment and an agent-based model for simulating water supply and distribution. This paper gives a general overview of the GLOWA-Danube project and describes the groundwater modeling segment. Nickel et al. deal with the water supply model in a second contribution to this special issue. A three-dimensional numerical groundwater flow model consisting of four main layers has been developed and is in a continual state of refinement (MODFLOW, [McDonald, M.G., Harbaugh, A.W., 1988. A modular three-dimensional finite-difference ground-water flow model: US Geological Survey Techniques of Water-Resources Investigations, Washington, USA (book 6, Chapter A1)]). One main research focus has been on the investigation of upscaling techniques to meet the requirement of a fixed 1 × 1 km cell size. This cell size is compulsory for all models in DANUBIA in order to facilitate a one to one parameter exchange. In a second stage, a transport model (nitrogen) will be added (MT3D: [Zheng, C., Hathaway, D.-L., 1991. MT3D: a new modular three-dimensional transport model and its application in predicting the persistence and transport of dissolved compounds from a gasoline spill, with implications for remediation. Association of Ground Water Scientists and Engineers Annual Meeting on Innovative Ground Water Technologies for the ’90s, National Ground Water Association, Westerville, Ohio, USA. Ground Water 29 (5)].

Lessons from forest FACE experiments provide guidance for Amazon-FACE science plan (Invited)

NASA Astrophysics Data System (ADS)

Norby, R. J.; Lapola, D. M.

2013-12-01

Free-air CO2 enrichment (FACE) experiments have provided novel insights into the ecological mechanisms controlling the cycling and storage of carbon in terrestrial ecosystems, and they provide a strong foundation for next-generation experiments in unexplored biomes. Specific lessons from FACE experiments include: (1) Carbon cycle responses are time-dependent because component processes have different rate constants: for example, net primary productivity is increased by elevated CO2, but the response may diminish with time as N cycling feedbacks become important. (2) Carbon partitioning patterns determine the fate of the extra C taken up by CO2-enriched plants, but partitioning responses remain an important challenge for ecosystem models. (3) The influence of N cycling on plant and ecosystem C cycling continues to be a critical uncertainty, and new experiments, especially in the tropics, must also consider P cycling. (4) Plant community structure can influence the ecosystem response to elevated CO2, but dynamic vegetation effects have not been adequately addressed. These experiences from FACE experiments in temperate forests are now guiding the development of a science plan for a FACE experiment in Amazonia. Models and small-scale experimental results agree that elevated CO2 will affect the metabolism of tropical ecosystems, but the qualitative and quantitative expression of the effects are largely unknown, representing a major source of uncertainty that limits our capacity to assess the vulnerability of the Amazon forest to climate change. Recognizing the high importance of the forests of the Amazon basin on global carbon, water, and energy cycles, biodiversity conservation, and the provision of essential services in Latin America, a consortium of Brazilian researchers and international collaborators have developed a science plan for Amazon-FACE. While the challenges presented both by infrastructure needs (roads, electricity, and provision of CO2) and biology (the size and diversity of the forest) are substantial, preliminary evaluation and past experience from temperate forest FACE experiments have supported the feasibility of an experiment comprising replicated 30-m diameter FACE plots in primary forest. The proposed site is the ZF2 research area 60 km north of Manaus and administered by Brazil's National Institute for Amazonia Research (INPA). The vegetation is representative of a dominant fraction of the forests occurring in the Amazon basin: old-growth closed-canopy terra firme (non-flooded) forest with trees 30-35 m in height on well drained clay soils. The major science questions guiding the experiment are closely informed by results of past FACE experiment and involve carbon metabolism, water use, nutrient cycling, interactions with environmental stressors, and the relationship between plant functional traits and community composition. FACE experiments can define ecological processes and mechanisms of responses for predictive models of ecosystem response, and models of CO2 response can define critical uncertainties and testable hypotheses for experiments; hence, the Amazon FACE experiment will feature a close integration of modeling and experimental approaches.

Effect of single- and two-cycle high hydrostatic pressure treatments on water properties, physicochemical and microbial qualities of minimally processed squids (todarodes pacificus).

PubMed

Zhang, Yifeng; Jiao, Shunshan; Lian, Zixuan; Deng, Yun; Zhao, Yanyun

2015-05-01

This study investigated the effect of single- and two-cycle high hydrostatic pressure (HHP) treatments on water properties, physicochemical, and microbial qualities of squids (Todarodes pacificus) during 4 °C storage for up to 10 d. Single-cycle treatments were applied at 200, 400, or 600 MPa for 20 min (S-200, S-400, and S-600), and two-cycle treatments consisted of two 10 min cycles at 200, 400, or 600 MPa, respectively (T-200, T-400, and T-600). HHP-treated samples had higher (P < 0.05) content of P2b (immobilized water) and P21 (myofibril water), but lower P22 (free water) than those of control. The single- and two-cycle HHP treatments at the same pressure level caused no significant difference in water state of squids. The two-cycle HHP treatment was more effective in controlling total volatile basic nitrogen, pH, and total plate counts (TPC) of squids during storage, in which TPC of S-600 and T-600 was 2.9 and 1.8 log CFU/g at 10 d, respectively, compared with 7.5 log CFU/g in control. HHP treatments delayed browning discoloration of the squids during storage, and the higher pressure level and two-cycle HHP were more effective. Water properties highly corresponded with color and texture indices of squids. This study demonstrated that the two-cycle HHP treatment was more effective in controlling microbial growth and quality deterioration while having similar impact on the physicochemical and water properties of squids in comparison with the single-cycle treatment, thus more desirable for extending shelf-life of fresh squids. © 2015 Institute of Food Technologists®

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Waste-to-energy: A review of life cycle assessment and its extension methods.

PubMed

Zhou, Zhaozhi; Tang, Yuanjun; Chi, Yong; Ni, Mingjiang; Buekens, Alfons

2018-01-01

This article proposes a comprehensive review of evaluation tools based on life cycle thinking, as applied to waste-to-energy. Habitually, life cycle assessment is adopted to assess environmental burdens associated with waste-to-energy initiatives. Based on this framework, several extension methods have been developed to focus on specific aspects: Exergetic life cycle assessment for reducing resource depletion, life cycle costing for evaluating its economic burden, and social life cycle assessment for recording its social impacts. Additionally, the environment-energy-economy model integrates both life cycle assessment and life cycle costing methods and judges simultaneously these three features for sustainable waste-to-energy conversion. Life cycle assessment is sufficiently developed on waste-to-energy with concrete data inventory and sensitivity analysis, although the data and model uncertainty are unavoidable. Compared with life cycle assessment, only a few evaluations are conducted to waste-to-energy techniques by using extension methods and its methodology and application need to be further developed. Finally, this article succinctly summarises some recommendations for further research.

The NIH-NIAID Filariasis Research Reagent Resource Center

PubMed Central

Michalski, Michelle L.; Griffiths, Kathryn G.; Williams, Steven A.; Kaplan, Ray M.; Moorhead, Andrew R.

2011-01-01

Filarial worms cause a variety of tropical diseases in humans; however, they are difficult to study because they have complex life cycles that require arthropod intermediate hosts and mammalian definitive hosts. Research efforts in industrialized countries are further complicated by the fact that some filarial nematodes that cause disease in humans are restricted in host specificity to humans alone. This potentially makes the commitment to research difficult, expensive, and restrictive. Over 40 years ago, the United States National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) established a resource from which investigators could obtain various filarial parasite species and life cycle stages without having to expend the effort and funds necessary to maintain the entire life cycles in their own laboratories. This centralized resource (The Filariasis Research Reagent Resource Center, or FR3) translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are unaware of the scope of materials and support provided by the FR3. This review is intended to provide a short history of the contract, brief descriptions of the fiilarial species and molecular resources provided, and an estimate of the impact the resource has had on the research community, and describes some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators. PMID:22140585

Project CUES: A New Middle-School Earth System Science Curriculum Being Developed by the American Geological Institute

NASA Astrophysics Data System (ADS)

Smith, M. C.; Smith, M. J.; Lederman, N.; Southard, J. B.; Rogers, E. A.; Callahan, C. N.

2002-12-01

Project CUES is a middle-school earth systems science curriculum project under development by the American Geological Institute (AGI) and funded by the National Science Foundation (ESI-0095938). CUES features a student-centered, inquiry pedagogy and approaches earth science from a systems perspective. CUES will use the expanded learning cycle approach of Trowbridge and Bybee (1996), known as the 5E model (engage-explore-explain-elaborate-evaluate). Unlike AGI's Investigating Earth Systems (IES) curriculum modules, CUES will include a single hard-bound textbook, and will take one school-year to complete. The textbook includes a prologue that addresses systems concepts and four main units: Geosphere, Hydrosphere, Atmosphere, and Biosphere. Each eight-week unit takes students through a progression from guided inquiry to open-ended, student-driven inquiry. During first 4 to 5 weeks of each unit, students explore important earth science phenomena and concepts through scripted investigations and narrative reading passages written by scientists as "inquiry narratives". The narratives address the development of scientific ideas and relay the personal experiences of a scientist during their scientific exploration. Aspects of the nature of science will be explicitly addressed in investigations and inquiry narratives. After the guided inquiry, students will develop a research proposal and conduct their own inquiry into local or regional scientific problems. Each unit culminates with a science conference at which students present their research. CUES will be the first NSF-funded, comprehensive earth systems textbook for middle school that is based on national standards. CUES will be pilot tested in 12 classrooms in January 2003, with a national field test of the program in 50 classrooms during the 2003-2004 school year.

Historical upscaling of the socio-hydrological cycle: Three cases from the Mediterranean Spain

NASA Astrophysics Data System (ADS)

Macian-Sorribes, Hector; Pulido-Velazquez, Manuel; Sanchis-Ibor, Carles

2015-04-01

Understanding the co-evolution between hydrological and socio-economic systems is vital to assess how anthropogenic and natural systems will evolve and interact in the future. Examining past socio-hydrological changes is therefore important to produce knowledge able to develop socio-hydrological models for predicting the future hydrology and society evolution patterns. As noticeable climate changes leading to higher water stress are expected in the Mediterranean Europe, socio-hydrological processes are likely to suffer considerable modifications in the XXI century, driving to potential conflicts as water demand increases while water resources fall. The goal of this contribution is to identify the hydro-social processes that have caused water conflicts, and how they have been solved in the Mediterranean Spain. The method is based in the analysis of historical documents, available since the Middle Ages. Once historical water conflicts (always well-documented) were located, a socio-hydrological "causal loop" is formulated, determining what caused that conflict, what factors or chain of factors were involved, and how it was addressed. Repeating that process for all the reported water conflicts allow us to gain insight into their driving forces, the socio-hydrological relationships linked to those, and the successful (and unsuccessful) strategies employed to address them. Three cases were selected from the Mediterranean Spain: the Mijares, the Turia and the Jucar river basins. All of them share similar documental sources (the Royal Archives, courts' archives, municipal archives and farmers' archives), similar climate and similar socio-economic backgrounds. Moreover, all of them are predicted to suffer similar climate change impacts. Irrigation is their major water demand. In these three rivers, during the last millennia, successive waterscapes have been constructed by different societies, in a prolonged process of institutional and environmental up-scaling, from the local level to the basin level, based on collaborative actions through multistakeholder partnerships and agreements. Irrigation development has played a major role in the evolutionary trend of the hydro-social cycle in the three basins, determining water demands and uses, and boosting institutional building. Following the main historical institutional milestones and examining the historical changes in water uses, remarkable differences can be found among the three cases, enhancing the high sensitivity of the hydrological processes with respect to socio-economic factors. Therefore, comparing them is adequate to find out those high-sensitive factors and the way they provoke the differences between the basins. The casual loop created a basin closure - basin reopening cycle. Basin closures were associated to increasing demands by population growth, irrigation and immigration, causing drought vulnerability. Basin reopenings corresponded to the building of regulation facilities (reservoirs, canals), the availability of new water sources (groundwater, regenerated water), or a change in the management strategies (conjunctive use). During basin closure, users fought during droughts but united to prevent new users' access to water. During reopenings, water use quickly increased, leading to basin closures. User conflicts were solved by user agreement in water sharing or by law requirement, establishing a new management policy. New-user conflicts were solved when the basin reopened again and those potential users gained access to water.

Dietary factors and luteal phase deficiency in healthy eumenorrheic women

PubMed Central

Andrews, Mary A.; Schliep, Karen C.; Wactawski-Wende, Jean; Stanford, Joseph B.; Zarek, Shvetha M.; Radin, Rose G.; Sjaarda, Lindsey A.; Perkins, Neil J.; Kalwerisky, Robyn A.; Hammoud, Ahmad O.; Mumford, Sunni L.

2015-01-01

STUDY QUESTION Are prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles? SUMMARY ANSWER Mediterranean Diet Score (MDS), fiber and isoflavone intake were positively associated with LPD while selenium was negatively associated with LPD after adjusting for age, percentage body fat and total energy intake. WHAT IS KNOWN ALREADY LPD may increase the risk of infertility and early miscarriage. Prior research has shown positive associations between LPD and low energy availability, either through high dietary restraint alone or in conjunction with high energy expenditure via exercise, but few studies with adequate sample sizes have been conducted investigating dietary factors and LPD among healthy, eumenorrheic women. STUDY DESIGN, SIZE, DURATION The BioCycle Study (2005–2007) prospectively enrolled 259 women from Western New York state, USA, and followed them for one (n = 9) or two (n = 250) menstrual cycles. PARTICIPANTS/MATERIALS, SETTING, METHODS Women aged 18–44 years, with self-reported BMI between 18 and 35 kg/m2 and cycle lengths between 21 and 35 days, were included in the study. Participants completed baseline questionnaires, four 24-h dietary recalls per cycle and daily diaries capturing vigorous exercise, perceived stress and sleep; they also provided up to eight fasting serum samples during clinic visits timed to specific phases of the menstrual cycle using a fertility monitor. Cycles were included for this analysis if the peak serum luteal progesterone was >1 ng/ml and a urine or serum LH surge was detected. Associations between prospectively assessed diet quality, macronutrients and micronutrients and LPD (defined as luteal duration <10 days) were evaluated using generalized linear models adjusting for age, percentage body fat and total energy intake. MAIN RESULTS AND THE ROLE OF CHANCE LPD occurred in 41 (8.9%) of the 463 cycles from 246 women in the final analysis. After adjusting for age, percentage body fat and total energy intake, LPD was positively associated with MDS, adjusted odds ratio (aOR): 1.70 (95% confidence interval [CI]: 1.17, 2.48), P = 0.01. In separate macro- and micronutrient adjusted models, increased fiber and isoflavone intake showed modest positive associations with LPD: fiber (per g), aOR: 1.10 (95% CI: 0.99, 1.23), P = 0.07; and isoflavones (per 10 mg), aOR: 1.38 (95% CI: 0.99, 1.92), P = 0.06. In contrast, selenium (per 10 mcg) was inversely associated with LPD, aOR: 0.80 (95% CI: 0.65, 0.97), P = 0.03. Additional adjustments for relevant lifestyle factors including vigorous exercise, perceived stress and sleep did not appreciably alter estimates. LIMITATIONS, REASONS FOR CAUTION The number of LPD cycles was limited, and thus these findings are exploratory. We relied on participant self-report of their medical history to apply exclusion criteria; it is possible that we admitted to the study women with a gynecologic or medical disease who were unaware of their diagnosis. WIDER IMPLICATIONS OF THE FINDINGS Our study suggests that diet quality may be associated with LPD among healthy eumenorrheic women. As LPD may contribute to infertility and early miscarriage, further research is warranted to elucidate how dietary factors, such as MDS, may influence LPD. The inverse association we found with selenium is supported by previous research and deserves further investigation to determine whether this finding has pathophysiologic and therapeutic implications. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. No competing interests declared. PMID:26082480

Dietary factors and luteal phase deficiency in healthy eumenorrheic women.

PubMed

Andrews, Mary A; Schliep, Karen C; Wactawski-Wende, Jean; Stanford, Joseph B; Zarek, Shvetha M; Radin, Rose G; Sjaarda, Lindsey A; Perkins, Neil J; Kalwerisky, Robyn A; Hammoud, Ahmad O; Mumford, Sunni L

2015-08-01

Are prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles? Mediterranean Diet Score (MDS), fiber and isoflavone intake were positively associated with LPD while selenium was negatively associated with LPD after adjusting for age, percentage body fat and total energy intake. LPD may increase the risk of infertility and early miscarriage. Prior research has shown positive associations between LPD and low energy availability, either through high dietary restraint alone or in conjunction with high energy expenditure via exercise, but few studies with adequate sample sizes have been conducted investigating dietary factors and LPD among healthy, eumenorrheic women. The BioCycle Study (2005-2007) prospectively enrolled 259 women from Western New York state, USA, and followed them for one (n = 9) or two (n = 250) menstrual cycles. Women aged 18-44 years, with self-reported BMI between 18 and 35 kg/m(2) and cycle lengths between 21 and 35 days, were included in the study. Participants completed baseline questionnaires, four 24-h dietary recalls per cycle and daily diaries capturing vigorous exercise, perceived stress and sleep; they also provided up to eight fasting serum samples during clinic visits timed to specific phases of the menstrual cycle using a fertility monitor. Cycles were included for this analysis if the peak serum luteal progesterone was >1 ng/ml and a urine or serum LH surge was detected. Associations between prospectively assessed diet quality, macronutrients and micronutrients and LPD (defined as luteal duration <10 days) were evaluated using generalized linear models adjusting for age, percentage body fat and total energy intake. LPD occurred in 41 (8.9%) of the 463 cycles from 246 women in the final analysis. After adjusting for age, percentage body fat and total energy intake, LPD was positively associated with MDS, adjusted odds ratio (aOR): 1.70 (95% confidence interval [CI]: 1.17, 2.48), P = 0.01. In separate macro- and micronutrient adjusted models, increased fiber and isoflavone intake showed modest positive associations with LPD: fiber (per g), aOR: 1.10 (95% CI: 0.99, 1.23), P = 0.07; and isoflavones (per 10 mg), aOR: 1.38 (95% CI: 0.99, 1.92), P = 0.06. In contrast, selenium (per 10 mcg) was inversely associated with LPD, aOR: 0.80 (95% CI: 0.65, 0.97), P = 0.03. Additional adjustments for relevant lifestyle factors including vigorous exercise, perceived stress and sleep did not appreciably alter estimates. The number of LPD cycles was limited, and thus these findings are exploratory. We relied on participant self-report of their medical history to apply exclusion criteria; it is possible that we admitted to the study women with a gynecologic or medical disease who were unaware of their diagnosis. Our study suggests that diet quality may be associated with LPD among healthy eumenorrheic women. As LPD may contribute to infertility and early miscarriage, further research is warranted to elucidate how dietary factors, such as MDS, may influence LPD. The inverse association we found with selenium is supported by previous research and deserves further investigation to determine whether this finding has pathophysiologic and therapeutic implications. This work was supported by the Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health. No competing interests declared. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Land Use and Land Cover Change in Forest Frontiers: The Role of Household Life Cycles

NASA Technical Reports Server (NTRS)

Walker, Robert

2002-01-01

Tropical deforestation remains a critical issue given its present rate and a widespread consensus regarding its implications for the global carbon cycle and biodiversity. Nowhere is the problem more pronounced than in the Amazon basin, home to the world's largest intact, tropical forest. This article addresses land cover change processes at household level in the Amazon basin, and to this end adapts a concept of domestic life cycle to the current institutional environment of tropical frontiers. In particular, it poses a risk minimization model that integrates demography with market-based factors such as transportation costs and accessibility. In essence, the article merges the theory of Chayanov with the household economy framework, in which markets exist for inputs (including labor), outputs, and capital. The risk model is specified and estimated, using survey data for 261 small producers along the Transamazon Highway in the eastern sector of the Brazilian Amazon.

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Exploring Use of Climate Information in Wildland Fire Management: A Decision Calendar Study

Treesearch

Thomas W. Corringham; Anthony L. Westerling; Barbara J. Morehouse

2006-01-01

Wildfire management is an institutionally complex process involving a complex budget and appropriations cycle, a variety of objectives, and a set of internal and external political constraints. Significant potential exists for enhancing the use of climate information and long-range climate forecasts in wildland fire management in the Western U.S. Written surveys and...

Leading Teams of Higher Education Administrators: Integrating Goal Setting, Team Role, and Team Life Cycle Theories

ERIC Educational Resources Information Center

Posthuma, Richard; Al-Riyami, Said

2012-01-01

Leaders of higher education institutions can create top management teams of academic administrators to guide and improve their organizations. This study illustrates how the leadership of top management teams can be accomplished successfully through a combination of goal setting (Doran, 1981; Locke & Latham, 1990), understanding of team roles…

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The Community College and the Business Cycle

ERIC Educational Resources Information Center

Romano, Richard M.; Palmer, James C.

2016-01-01

Swings in enrollment and funding caused by the most recent recession have reminded community college leaders that the ups and downs of the economy can have a significant impact on their institutions. While the impact on enrollment and funding is well documented, lesser known impacts can be also be found on things such as student persistence,…

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From Data Entry to Evidence-Based Decision-Making: How Data and Analysis Can Drive Improvements in Admissions Policies

ERIC Educational Resources Information Center

Hourigan, Clare

2011-01-01

Academic standards and performance outcomes are a major focus of the current Cycle 2 Australian Universities Quality Agency (AUQA) audits. AUQA has clearly stated that universities will need to provide "evidence of setting, maintaining, and reviewing institutional academic standards and outcomes" (2010, p. 27). To do this, universities…

Learning from the continuities in humanity and nature

Treesearch

William R., Jr. Burch

1977-01-01

Though the emphasis in American life is upon dramatic social change, the firmer reality is our great continuity in social behavior and institutions. For example, though many strategies of child rearing have cycled through human society, the basic problems and responsible social unit remain the same. Of necessity, children have an ordered and holistic view of nature and...

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First Nations Development Institute Biennial Report, 1994/95.

ERIC Educational Resources Information Center

First Nations Development Inst., Fredericksburg, VA.

This report describes economic development projects that were funded during 1994-95 by the First Nations Development Institute. The Institute was established in 1980 to help tribes build sound, sustainable reservation economies. Through the Eagle Staff Fund, the Institute regrants funds for culturally viable economic development projects from a…

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System Analysis for Decay Heat Removal in Lead-Bismuth Cooled Natural Circulated Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takaaki Sakai; Yasuhiro Enuma; Takashi Iwasaki

2002-07-01

Decay heat removal analyses for lead-bismuth cooled natural circulation reactors are described in this paper. A combined multi-dimensional plant dynamics code (MSG-COPD) has been developed to conduct the system analysis for the natural circulation reactors. For the preliminary study, transient analysis has been performed for a 100 MWe lead-bismuth-cooled reactor designed by Argonne National Laboratory (ANL). In addition, decay heat removal characteristics of a 400 MWe lead-bismuth-cooled natural circulation reactor designed by Japan Nuclear Cycle Development Institute (JNC) has been evaluated by using MSG-COPD. PRACS (Primary Reactor Auxiliary Cooling System) is prepared for the JNC's concept to get sufficient heatmore » removal capacity. During 2000 sec after the transient, the outlet temperature shows increasing tendency up to the maximum temperature of 430 Centigrade, because the buoyancy force in a primary circulation path is temporary reduced. However, the natural circulation is recovered by the PRACS system and the out let temperature decreases successfully. (authors)« less

System Analysis for Decay Heat Removal in Lead-Bismuth-Cooled Natural-Circulation Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sakai, Takaaki; Enuma, Yasuhiro; Iwasaki, Takashi

2004-03-15

Decay heat removal analyses for lead-bismuth-cooled natural-circulation reactors are described in this paper. A combined multidimensional plant dynamics code (MSG-COPD) has been developed to conduct the system analysis for the natural-circulation reactors. For the preliminary study, transient analysis has been performed for a 300-MW(thermal) lead-bismuth-cooled reactor designed by Argonne National Laboratory. In addition, decay heat removal characteristics of a 400-MW(electric) lead-bismuth-cooled natural-circulation reactor designed by the Japan Nuclear Cycle Development Institute (JNC) has been evaluated by using MSG-COPD. The primary reactor auxiliary cooling system (PRACS) is prepared for the JNC concept to get sufficient heat removal capacity. During 2000 smore » after the transient, the outlet temperature shows increasing tendency up to the maximum temperature of 430 deg. C because the buoyancy force in a primary circulation path is temporarily reduced. However, the natural circulation is recovered by the PRACS system, and the outlet temperature decreases successfully.« less

An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome.

PubMed

Ahmed, Tahmeed; Auble, David; Berkley, James A; Black, Robert; Ahern, Philip P; Hossain, Muttaquina; Hsieh, Andrea; Ireen, Santhia; Arabi, Mandana; Gordon, Jeffrey I

2014-12-01

The Sackler Institute for Nutrition Science and the World Health Organization (WHO) have worked together to formulate a research agenda for nutrition science. Undernutrition of children has profound effects on health, development, and achievement of full human capacity. Undernutrition is not simply caused by a lack of food, but results from a complex interplay of intra- and intergenerational factors. Representative preclinical models and comprehensive well-controlled longitudinal clinical studies are needed to further understand the contributions and the interrelationships among these factors and to develop interventions that are effective and durable. This paper summarizes work on mechanisms underlying the varied manifestations of childhood undernutrition and discusses current gaps in knowledge and challenges to our understanding of undernutrition and infection/immunity throughout the human life cycle, focusing on early childhood growth. It proposes a series of basic and clinical studies to address this global health challenge. © 2014 New York Academy of Sciences.

Enhancements to a Superconducting Quantum Interference Device (SQUID) Multiplexer Readout and Control System

NASA Technical Reports Server (NTRS)

Forgione, J.; Benford, D. J.; Buchanan, E. D.; Moseley, S. H.; Rebar, J.; Shafer, R. A.

2004-01-01

Far-infrared detector arrays such as the 16x32 superconducting bolometer array for the SAFIRE instrument (flying on the SOFIA airborne observatory) require systems of readout and control electronics to provide translation between a user-driven, digital PC and the cold, analog world of the cryogenic detector. In 2001, the National Institute of Standards and Technology (NIST) developed their Mark III electronics for purposes of control and readout of their 1x32 SQUID Multiplexer chips. We at NASA s Goddard Space Flight Center acquired a Mark 111 system and subsequently designed upgrades to suit our and our collaborators purposes. We developed an arbitrary, programmable multiplexing system that allows the user to cycle through rows in a SQUID array in an infinite number of combinations. We provided hooks in the Mark III system to allow readout of signals from outside the Mark 111 system, such as telescope status information. Finally, we augmented the heart of the system with a new feedback algorithm implementation, flexible diagnostic tools, and informative telemetry.

A flexible tool for diagnosing water, energy, and entropy budgets in climate models

NASA Astrophysics Data System (ADS)

Lembo, Valerio; Lucarini, Valerio

2017-04-01

We have developed a new flexible software for studying the global energy budget, the hydrological cycle, and the material entropy production of global climate models. The program receives as input radiative, latent and sensible energy fluxes, with the requirement that the variable names are in agreement with the Climate and Forecast (CF) conventions for the production of NetCDF datasets. Annual mean maps, meridional sections and time series are computed by means of Climate Data Operators (CDO) collection of command line operators developed at Max-Planck Institute for Meteorology (MPI-M). If a land-sea mask is provided, the program also computes the required quantities separately on the continents and oceans. Depending on the user's choice, the program also calls the MATLAB software to compute meridional heat transports and location and intensities of the peaks in the two hemispheres. We are currently planning to adapt the program in order to be included in the Earth System Model eValuation Tool (ESMValTool) community diagnostics.

Development of a remote-controlled fatigue test machine using a laser extensometer for investigation of irradiation effect on fatigue properties

NASA Astrophysics Data System (ADS)

Yonekawa, M.; Ishii, T.; Ohmi, M.; Takada, F.; Hoshiya, T.; Niimi, M.; Ioka, I.; Miwa, Y.; Tsuji, H.

2002-12-01

In order to investigate effects of neutron irradiation on fatigue properties of nuclear materials, a remote-controlled high temperature fatigue test machine was developed at the hot laboratory of the Japan Materials Testing Reactor (JMTR) in the Japan Atomic Energy Research Institute (JAERI). A small-sized fatigue specimen having double blades to measure strain with a laser extensometer was designed for this machine. A strain amplitude in fatigue tests of a completely reversed push-pull type using a triangular wave was controlled with an accuracy of ±3% of the total strain range during test. Low cycle fatigue tests of type 304 stainless steel irradiated in JMTR at 823 K up to a fast neutron fluence of 1×10 25 n/m 2 ( E>1 MeV) were performed in total strain ranges of 0.7-1.4% at 823 K using the designed small-sized specimens.

Enhancements to a superconducting quantum interference device (SQUID) multiplexer readout and control system

NASA Astrophysics Data System (ADS)

Forgione, Joshua B.; Benford, Dominic J.; Buchanan, Ernest D.; Moseley, S. H., Jr.; Rebar, Joyce; Shafer, Richard A.

2004-10-01

Far-infrared detector arrays such as the 16x32 superconducting bolometer array for the SAFIRE instrument (flying on the SOFIA airborne observatory) require systems of readout and control electronics to provide translation between a user-driven, digital PC and the cold, analog world of the cryogenic detector. In 2001, the National Institute of Standards and Technology (NIST) developed their Mark III electronics for purposes of control and readout of their 1x32 SQUID Multiplexer chips. We at NASA's Goddard Space Flight Center acquired a Mark III system and subsequently designed upgrades to suit our and our collaborators' purposes. We developed an arbitrary, programmable multiplexing system that allows the user to cycle through rows in a SQUID array in an infinite number of combinations. We provided 'hooks' in the Mark III system to allow readout of signals from outside the Mark III system, such as telescope status information. Finally, we augmented the heart of the system with a new feedback algorithm implementation, flexible diagnostic tools, and informative telemetry.

From waste to sustainable materials management: Three case studies of the transition journey.

PubMed

Silva, Angie; Rosano, Michele; Stocker, Laura; Gorissen, Leen

2017-03-01

Waste policy is increasingly moving on from the 'prevention of waste' to a 'sustainable materials policy' focused agenda recognising individual wastes as a resource. In order to comparatively analyse policy developments in enhanced waste management, three case studies were selected; San Francisco's Zero Waste Program, Flanders's Sustainable Materials Management Initiative and Japan's Sound Material-Cycle Society Plan. These case studies were chosen as an opportunity to investigate the variety of leading approaches, governance structures, and enhanced waste policy outcomes, emerging globally. This paper concludes that the current transitional state of waste management across the world, is only in the first leg of the journey towards Circular Economy closed loop production models of waste as a resource material. It is suggested that further development in government policy, planning and behaviour change is required. A focus on material policy and incorporating multiple front runners across industry and knowledge institutions are offered as potential directions in the movement away from end-pipe land-fill solutions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Isolating Tracers of Phytoplankton with Allometric Zooplankton (TOPAZ) from Modular Ocean Model (MOM5) to Couple it with a Global Ocean Model

NASA Astrophysics Data System (ADS)

Jung, H. C.; Moon, B. K.; Wie, J.; Park, H. S.; Kim, K. Y.; Lee, J.; Byun, Y. H.

2017-12-01

This research is motivated by a need to develop a new coupled ocean-biogeochemistry model, a key tool for climate projections. The Modular Ocean Model (MOM5) is a global ocean/ice model developed by the Geophysical Fluid Dynamics Laboratory (GFDL) in the US, and it incorporates Tracers of Phytoplankton with Allometric Zooplankton (TOPAZ), which simulates the marine biota associated with carbon cycles. We isolated TOPAZ from MOM5 into a stand-alone version (TOPAZ-SA), and had it receive initial data and ocean physical fields required. Then, its reliability was verified by comparing the simulation results from the TOPAZ-SA with the MOM5/TOPAZ. This stand-alone version of TOPAZ is to be coupled to the Nucleus for European Modelling of the Ocean (NEMO). Here we present the preliminary results. Acknowledgements This research was supported by the project "Research and Development for KMA Weather, Climate, and Earth system Services" (NIMS-2016-3100) of the National Institute of Meteorological Sciences/Korea Meteorological Administration.

Community Resilience Informed by Science and Experience (C-RISE)

NASA Astrophysics Data System (ADS)

Young Morse, R.; Peake, L.; Bowness, G.

2017-12-01

The Gulf of Maine Research Institute is developing an interactive learning experience that engages participants in the interdependence of humans and the environment, the cycles of observation and experiment that advance science knowledge, and the changes we see now and that are predicted for sea level and storm frequency. These scientific concepts and principles will be brought to human scale through the connection to the challenge of city planning in our harbor communities. We are leveraging the ESRI Story Maps platform to build rich visualization-based narratives that feature NOAA maps, data and tools. Our program participants work in teams to navigate the content and participate in facilitated group discussions led by our educators. Based on the adult learning experience and in concert with new content being developed for the LabVenture program around the theme of Climate Change, we will develop a learning experience for 5th and 6th graders.Our goal is to immerse 1000+ adults from target communities in Greater Portland region as well as 8000+ middle school students from throughout the state in the experience.

General presentation including new structure

NASA Astrophysics Data System (ADS)

Soons, A.

2002-12-01

Electrical, electronic and electro-mechanical components play an essential role in the functional performance, quality, life cycle and costs of space systems. Their standardisation, product specification, development, evaluation, qualification and procurement must be based on a coherent and efficient approach, paying due attention to present and prospective European space policies and must be commensurate with user needs, market developments and technology trends. The European Space Components Coordination (ESCC) is established with the objective of harmonising the efforts concerning the various aspects of EEE space components by ESA. European national and international public space organisations, the component manufacturers and the user industries. The goal of the ESCC is to improve the availability of strategic EEE space components with the required performance and at affordable costs for institutional and commercial space programmes. It is the objective of ESCC to achieve this goal by harmonising the resources and development efforts for space components in the ESA Member States and by providing a single and unified system for the standardisation, product specification, evaluation, qualification and procurement of European EEE space components and for the certification of components and component manufacturers.

Technology-enabled assessment of health professions education: consensus statement and recommendations from the Ottawa 2010 Conference.

PubMed

Amin, Zubair; Boulet, John R; Cook, David A; Ellaway, Rachel; Fahal, Ahmad; Kneebone, Roger; Maley, Moira; Ostergaard, Doris; Ponnamperuma, Gominda; Wearn, Andy; Ziv, Amitai

2011-01-01

The uptake of information and communication technologies (ICTs) in health professions education can have far-reaching consequences on assessment. The medical education community still needs to develop a deeper understanding of how technology can underpin and extend assessment practices. This article was developed by the 2010 Ottawa Conference Consensus Group on technology-enabled assessment to guide practitioners and researchers working in this area. This article highlights the changing nature of ICTs in assessment, the importance of aligning technology-enabled assessment with local context and needs, the need for better evidence to support use of technologies in health profession education assessment, and a number of challenges, particularly validity threats, that need to be addressed while incorporating technology in assessment. Our recommendations are intended for all practitioners across health professional education. Recommendations include adhering to principles of good assessment, the need for developing coherent institutional policy, using technologies to broaden the competencies to be assessed, linking patient-outcome data to assessment of practitioner performance, and capitalizing on technologies for the management of the entire life-cycle of assessment.

Minimum impulse thruster valve design and development

NASA Technical Reports Server (NTRS)

Huftalen, Richard L.; Platt, Andrea L.; Parker, Morgan J.; Yankura, George A.

2003-01-01

The design and development of a minimum impulse thruster valve was conducted, by Moog, under contract by NASA's Jet Propulsion Laboratory, California Institute of Technology, for deep space propulsion systems. The effort was focused on applying known solenoid design techniques scaled to provide a 1 -millisecond response capability for monopropellant, hydrazine ACS thruster applications. The valve has an extended operating temperature range of 20(deg)F to +350(deg)F with a total mass of less than 25 grams and nominal power draw of 7 watts. The design solution resulted in providing a solenoid valve that is one-tenth the scale of the standard product line. The valve has the capability of providing a mass flow rate of 0.0009 pounds per second hydrazine. The design life of 1,000,000 cycles was demonstrated both dry and wet. Not all design factors scaled as expected and proved to be the focus of the final development effort. These included the surface interactions, hydrodynamics and driver electronics. The resulting solution applied matured design approaches to minimize the program risk with innovative methods to address the impacts of scale.

Emissivity of Candidate Materials for VHTR Applicationbs: Role of Oxidation and Surface Modification Treatments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sridharan, Kumar; Allen, Todd; Anderson, Mark

The Generation IV (GEN IV) Nuclear Energy Systems Initiative was instituted by the Department of Energy (DOE) with the goal of researching and developing technologies and materials necessary for various types of future reactors. These GEN IV reactors will employ advanced fuel cycles, passive safety systems, and other innovative systems, leading to significant differences between these future reactors and current water-cooled reactors. The leading candidate for the Next Generation Nuclear Plant (NGNP) to be built at Idaho National Lab (INL) in the United States is the Very High Temperature Reactor (VHTR). Due to the high operating temperatures of the VHTR,more » the Reactor Pressure Vessel (RPV) will partially rely on heat transfer by radiation for cooling. Heat expulsion by radiation will become all the more important during high temperature excursions during off-normal accident scenarios. Radiant power is dictated by emissivity, a material property. The NGNP Materials Research and Development Program Plan [1] has identified emissivity and the effects of high temperature oxide formation on emissivity as an area of research towards the development of the VHTR.« less

Factors influencing breeding success, ovarian cyclicity, and cub survival in zoo-managed tigers (Panthera tigris).

PubMed

Saunders, Sarah P; Harris, Tara; Traylor-Holzer, Kathy; Beck, Karen Goodrowe

2014-01-10

Understanding factors that influence reproduction and offspring survival in zoo populations is critical for management of threatened and endangered species. Examination of long-term data (1989-2011) compiled from the Association of Zoos and Aquarium's zoo-managed tiger breeding program provides the basis for a more thorough understanding of reproduction and scientifically based decisions for effective population management in this endangered felid. Biological and management-related factors that could influence tiger breeding success and cub survival were evaluated using logistic mixed models. Breeding success improved with female age until approximately age five, then declined thereafter. Experienced female breeders had greater breeding success than inexperienced females. Litter size was most predictive of cub survival, with average-sized litters (3-4 cubs) experiencing the highest proportional survival. Management-related factors, such as whether the breeding institution had a recent tiger litter and whether both animals were already located at the same institution, also influenced breeding success and cub survival. These results highlight the importance of institutional husbandry experience and the need to retain knowledge through staff turnovers to achieve optimal reproductive success. Using fecal estrogen data, frequency of ovarian cyclicity and mean cycle length did not differ by female age or parity; thus, lack of cyclicity and/or increased cycle duration are not likely explanations for declining breeding success with age. These results provide valuable reproductive information that should improve scientific management of zoo-based tiger populations. Copyright © 2013 Elsevier B.V. All rights reserved.

An Approach for Assessing Development and Deployment Risks in the DOE Fuel Cycle Options Evaluation and Screening Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gehin, Jess C; Oakley, Brian; Worrall, Andrew

2015-01-01

Abstract One of the key objectives of the U.S. Department of Energy (DOE) Nuclear Energy R&D Roadmap is the development of sustainable nuclear fuel cycles that can improve natural resource utilization and provide solutions to the management of nuclear wastes. Recently, an evaluation and screening (E&S) of fuel cycle systems has been conducted to identify those options that provide the best opportunities for obtaining such improvements and also to identify the required research and development activities that can support the development of advanced fuel cycle options. In order to evaluate and screen the E&S study included nine criteria including Developmentmore » and Deployment Risk (D&DR). More specifically, this criterion was represented by the following metrics: Development time, development cost, deployment cost from prototypic validation to first-of-a-kind commercial, compatibility with the existing infrastructure, existence of regulations for the fuel cycle and familiarity with licensing, and existence of market incentives and/or barriers to commercial implementation of fuel cycle processes. Given the comprehensive nature of the study, a systematic approach was needed to determine metric data for the D&DR criterion, and is presented here. As would be expected, the Evaluation Group representing the once-through use of uranium in thermal reactors is always the highest ranked fuel cycle Evaluation Group for this D&DR criterion. Evaluation Groups that consist of once-through fuel cycles that use existing reactor types are consistently ranked very high. The highest ranked limited and continuous recycle fuel cycle Evaluation Groups are those that recycle Pu in thermal reactors. The lowest ranked fuel cycles are predominately continuous recycle single stage and multi-stage fuel cycles that involve TRU and/or U-233 recycle.« less

MetNet Precursor - Network Mission to Mars

NASA Astrophysics Data System (ADS)

Harri, Arri-Matti

2010-05-01

We are developing a new kind of planetary exploration mission for Mars - MetNet in situ observation network based on a new semi-hard landing vehicle called the Met-Net Lander (MNL). The first MetNet vehicle, MetNet Precursor, slated for launch in 2011. The MetNet development work started already in 2001. The actual practical Precursor Mission development work started in January 2009 with participation from various space research institutes and agencies. The scientific rationale and goals as well as key mission solutions will be discussed. The eventual scope of the MetNet Mission is to deploy some 20 MNLs on the Martian surface using inflatable descent system structures, which will be supported by observations from the orbit around Mars. Currently we are working on the MetNet Mars Precursor Mission (MMPM) to deploy one MetNet Lander to Mars in the 2011 launch window as a technology and science demonstration mission. The MNL will have a versatile science payload focused on the atmospheric science of Mars. Time-resolved in situ Martian meteorological measurements acquired by the Viking, Mars Pathfinder and Phoenix landers and remote sensing observations by the Mariner 9, Viking, Mars Global Surveyor, Mars Odyssey and the Mars Express orbiters have provided the basis for our current understanding of the behavior of weather and climate on Mars. However, the available amount of data is still scarce and a wealth of additional in situ observations are needed on varying types of Martian orography, terrain and altitude spanning all latitudes and longitudes to address microscale and mesoscale atmospheric phenomena. Detailed characterization of the Martian atmospheric circulation patterns and climatological cycles requires simultaneous in situ atmospheric observations. The scientific payload of the MetNet Mission encompasses separate instrument packages for the atmospheric entry and descent phase and for the surface operation phase. The MetNet mission concept and key probe technologies have been developed and the critical subsystems have been qualified to meet the Martian environmental and functional conditions. The flight unit of the landing vehicle has been manufactured and tested. This development effort has been fulfilled in collaboration between the Finnish Meteorological Institute (FMI), the Russian Lavoschkin Association (LA) and the Russian Space Research Institute (IKI) since August 2001. INTA (Instituto Nacional de Técnica Aeroespacial) from Spain joined the MetNet Mission team in 2008, and is participating significantly in the MetNet payload development.