All orders results for self-crossing Wilson loops mimicking double parton scattering

NASA Astrophysics Data System (ADS)

Dixon, Lance J.; Esterlis, Ilya

2016-07-01

Loop-level scattering amplitudes for massless particles have singularities in regions where tree amplitudes are perfectly smooth. For example, a 2 → 4 gluon scattering process has a singularity in which each incoming gluon splits into a pair of gluons, followed by a pair of 2 → 2 collisions between the gluon pairs. This singularity mimics double parton scattering because it occurs when the transverse momentum of a pair of outgoing gluons vanishes. The singularity is logarithmic at fixed order in perturbation theory. We exploit the duality between scattering amplitudes and polygonal Wilson loops to study six-point amplitudes in this limit to high loop order in planar {N} = 4 super-Yang-Mills theory. The singular configuration corresponds to the limit in which a hexagonal Wilson loop develops a self-crossing. The singular terms are governed by an evolution equation, in which the hexagon mixes into a pair of boxes; the mixing back is suppressed in the planar (large N c) limit. Because the kinematic dependence of the box Wilson loops is dictated by (dual) conformal invariance, the complete kinematic dependence of the singular terms for the self-crossing hexagon on the one nonsingular variable is determined to all loop orders. The complete logarithmic dependence on the singular variable can be obtained through nine loops, up to a couple of constants, using a correspondence with the multi-Regge limit. As a byproduct, we obtain a simple formula for the leading logs to all loop orders. We also show that, although the MHV six-gluon amplitude is singular, remarkably, the transcendental functions entering the non-MHV amplitude are finite in the same limit, at least through four loops.

The contribution of scalars to N = 4 SYM amplitudes II: Young tableaux, asymptotic factorisation and strong coupling

NASA Astrophysics Data System (ADS)

Bonini, Alfredo; Fioravanti, Davide; Piscaglia, Simone; Rossi, Marco

2018-06-01

We disentangle the contribution of scalars to the OPE series of null hexagonal Wilson loops/MHV gluon scattering amplitudes in multicolour N = 4 SYM. In specific, we develop a systematic computation of the SU (4) matrix part of the Wilson loop by means of Young tableaux (with several examples). Then, we use a peculiar factorisation property (when a group of rapidities becomes large) to deduce an explicit polar form. Furthermore, we emphasise the advantages of expanding the logarithm of the Wilson loop in terms of 'connected functions' as we apply this procedure to find an explicit strong coupling expansion (definitively proving that the leading order can prevail on the classical AdS5 string contribution).

Perturbative expansions from Monte Carlo simulations at weak coupling: Wilson loops and the static-quark self-energy

NASA Astrophysics Data System (ADS)

Trottier, H. D.; Shakespeare, N. H.; Lepage, G. P.; MacKenzie, P. B.

2002-05-01

Perturbative coefficients for Wilson loops and the static-quark self-energy are extracted from Monte Carlo simulations at weak coupling. The lattice volumes and couplings are chosen to ensure that the lattice momenta are all perturbative. Twisted boundary conditions are used to eliminate the effects of lattice zero modes and to suppress nonperturbative finite-volume effects due to Z(3) phases. Simulations of the Wilson gluon action are done with both periodic and twisted boundary conditions, and over a wide range of lattice volumes (from 34 to 164) and couplings (from β~9 to β~60). A high precision comparison is made between the simulation data and results from finite-volume lattice perturbation theory. The Monte Carlo results are shown to be in excellent agreement with perturbation theory through second order. New results for third-order coefficients for a number of Wilson loops and the static-quark self-energy are reported.

The massive soft anomalous dimension matrix at two loops

NASA Astrophysics Data System (ADS)

Mitov, Alexander; Sterman, George; Sung, Ilmo

2009-05-01

We study two-loop anomalous dimension matrices in QCD and related gauge theories for products of Wilson lines coupled at a point. We verify by an analysis in Euclidean space that the contributions to these matrices from diagrams that link three massive Wilson lines do not vanish in general. We show, however, that for two-to-two processes the two-loop anomalous dimension matrix is diagonal in the same color-exchange basis as the one-loop matrix for arbitrary masses at absolute threshold and for scattering at 90 degrees in the center of mass. This result is important for applications of threshold resummation in heavy quark production.

Double-winding Wilson loops in SU(N) Yang-Mills theory - A criterion for testing the confinement models -

NASA Astrophysics Data System (ADS)

Matsudo, Ryutaro; Kondo, Kei-Ichi; Shibata, Akihiro

2018-03-01

We examine how the average of double-winding Wilson loops depends on the number of color N in the SU(N) Yang-Mills theory. In the case where the two loops C1 and C2 are identical, we derive the exact operator relation which relates the doublewinding Wilson loop operator in the fundamental representation to that in the higher dimensional representations depending on N. By taking the average of the relation, we find that the difference-of-areas law for the area law falloff recently claimed for N = 2 is excluded for N ⩾ 3, provided that the string tension obeys the Casimir scaling for the higher representations. In the case where the two loops are distinct, we argue that the area law follows a novel law (N - 3)A1/(N - 1) + A2 with A1 and A2(A1 < A2) being the minimal areas spanned respectively by the loops C1 and C2, which is neither sum-ofareas (A1 + A2) nor difference-of-areas (A2 - A1) law when (N ⩾ 3). Indeed, this behavior can be confirmed in the two-dimensional SU(N) Yang-Mills theory exactly.

Magnetic monopole versus vortex as gauge-invariant topological objects for quark confinement

NASA Astrophysics Data System (ADS)

Kondo, Kei-Ichi; Sasago, Takaaki; Shinohara, Toru; Shibata, Akihiro; Kato, Seikou

2017-12-01

First, we give a gauge-independent definition of chromomagnetic monopoles in SU(N) Yang-Mills theory which is derived through a non-Abelian Stokes theorem for the Wilson loop operator. Then we discuss how such magnetic monopoles can give a nontrivial contribution to the Wilson loop operator for understanding the area law of the Wilson loop average. Next, we discuss how the magnetic monopole condensation picture are compatible with the vortex condensation picture as another promising scenario for quark confinement. We analyze the profile function of the magnetic flux tube as the non-Abelian vortex solution of U(N) gauge-Higgs model, which is to be compared with numerical simulations of the SU(N) Yang-Mills theory on a lattice. This analysis gives an estimate of the string tension based on the vortex condensation picture, and possible interactions between two non-Abelian vortices.

Comments on higher rank Wilson loops in N = 2∗

NASA Astrophysics Data System (ADS)

Liu, James T.; Zayas, Leopoldo A. Pando; Zhou, Shan

2018-01-01

For N = 2∗ theory with U( N ) gauge group we evaluate expectation values of Wilson loops in representations described by a rectangular Young tableau with n rows and k columns. The evaluation reduces to a two-matrix model and we explain, using a combination of numerical and analytical techniques, the general properties of the eigen-value distributions in various regimes of parameters ( N, λ , n, k) where λ is the 't Hooft coupling. In the large N limit we present analytic results for the leading and sub-leading contributions. In the particular cases of only one row or one column we reproduce previously known results for the totally symmetry and totally antisymmetric representations. We also extensively discusss the N = 4 limit of the N = 2∗ theory. While establishing these connections we clarify aspects of various orders of limits and how to relax them; we also find it useful to explicitly address details of the genus expansion. As a result, for the totally symmetric Wilson loop we find new contributions that improve the comparison with the dual holographic computation at one loop order in the appropriate regime.

Higher rank ABJM Wilson loops from matrix models

DOE PAGES

Cookmeyer, Jonathan; Liu, James T.; Pando Zayas, Leopoldo A.

2016-11-21

We compute the vacuum expectation values of 1/6 supersymmetric Wilson loops in higher dimensional representations of the gauge group in ABJM theory. We then present results for the m-symmetric and m-antisymmetric representations by exploiting standard matrix model techniques. At leading order, in the saddle point approximation, our expressions reproduce holographic results from both D6 and D2 branes corresponding to the antisymmetric and symmetric representations, respectively. We also compute 1/N corrections to the leading saddle point results.

Schwarzschild radius from Monte Carlo calculation of the Wilson loop in supersymmetric matrix quantum mechanics.

PubMed

Hanada, Masanori; Miwa, Akitsugu; Nishimura, Jun; Takeuchi, Shingo

2009-05-08

In the string-gauge duality it is important to understand how the space-time geometry is encoded in gauge theory observables. We address this issue in the case of the D0-brane system at finite temperature T. Based on the duality, the temporal Wilson loop W in gauge theory is expected to contain the information of the Schwarzschild radius RSch of the dual black hole geometry as log(W)=RSch/(2pialpha'T). This translates to the power-law behavior log(W)=1.89(T/lambda 1/3)-3/5, where lambda is the 't Hooft coupling constant. We calculate the Wilson loop on the gauge theory side in the strongly coupled regime by performing Monte Carlo simulations of supersymmetric matrix quantum mechanics with 16 supercharges. The results reproduce the expected power-law behavior up to a constant shift, which is explainable as alpha' corrections on the gravity side. Our conclusion also demonstrates manifestly the fuzzball picture of black holes.

WiLE: A Mathematica package for weak coupling expansion of Wilson loops in ABJ(M) theory

NASA Astrophysics Data System (ADS)

Preti, M.

2018-06-01

We present WiLE, a Mathematica® package designed to perform the weak coupling expansion of any Wilson loop in ABJ(M) theory at arbitrary perturbative order. For a given set of fields on the loop and internal vertices, the package displays all the possible Feynman diagrams and their integral representations. The user can also choose to exclude non planar diagrams, tadpoles and self-energies. Through the use of interactive input windows, the package should be easily accessible to users with little or no previous experience. The package manual provides some pedagogical examples and the computation of all ladder diagrams at three-loop relevant for the cusp anomalous dimension in ABJ(M). The latter application gives also support to some recent results computed in different contexts.

Comments on higher rank Wilson loops in N$$ \\mathcal{N} $$ = 2∗

DOE PAGES

Liu, James T.; Zayas, Leopoldo A. Pando; Zhou, Shan

2018-01-01

For N = 2∗ theory with U(N) gauge group we evaluate expectation values of Wilson loops in representations described by a rectangular Young tableau with n rows and k columns. The evaluation reduces to a two-matrix model and we explain, using a combination of numerical and analytical techniques, the general properties of the eigenvalue distributions in various regimes of parameters (N, λ, n, k) where λ is the ’t Hooft coupling. In the large N limit we present analytic results for the leading and sub-leading contributions. In the particular cases of only one row or one column we reproduce previouslymore » known results for the totally symmetry and totally antisymmetric representations. We also extensively discusss the N = 4 limit of the N = 2∗ theory. While establishing these connections we clarify aspects of various orders of limits and how to relax them; we also find it useful to explicitly address details of the genus expansion. As a result, for the totally symmetric Wilson loop we find new contributions that improve the comparison with the dual holographic computation at one loop order in the appropriate regime.« less

Exact correlators on the Wilson loop in N=4 SYM: localization, defect CFT, and integrability

NASA Astrophysics Data System (ADS)

Giombi, Simone; Komatsu, Shota

2018-05-01

We compute a set of correlation functions of operator insertions on the 1 /8 BPS Wilson loop in N=4 SYM by employing supersymmetric localization, OPE and the Gram-Schmidt orthogonalization. These correlators exhibit a simple determinant structure, are position-independent and form a topological subsector, but depend nontrivially on the 't Hooft coupling and the rank of the gauge group. When applied to the 1 /2 BPS circular (or straight) Wilson loop, our results provide an infinite family of exact defect CFT data, including the structure constants of protected defect primaries of arbitrary length inserted on the loop. At strong coupling, we show precise agreement with a direct calculation using perturbation theory around the AdS2 string worldsheet. We also explain the connection of our results to the "generalized Bremsstrahlung functions" previously computed from integrability techniques, reproducing the known results in the planar limit as well as obtaining their finite N generalization. Furthermore, we show that the correlators at large N can be recast as simple integrals of products of polynomials (known as Q-functions) that appear in the Quantum Spectral Curve approach. This suggests an interesting interplay between localization, defect CFT and integrability.

Loop equations and bootstrap methods in the lattice

DOE PAGES

Anderson, Peter D.; Kruczenski, Martin

2017-06-17

Pure gauge theories can be formulated in terms of Wilson Loops by means of the loop equation. In the large-N limit this equation closes in the expectation value of single loops. In particular, using the lattice as a regulator, it becomes a well defined equation for a discrete set of loops. In this paper we study different numerical approaches to solving this equation.

Higher Rank ABJM Wilson Loops from Matrix Models

NASA Astrophysics Data System (ADS)

Cookmeyer, Jonathan; Liu, James; Zayas, Leopoldo

2017-01-01

We compute the expectation values of 1/6 supersymmetric Wilson Loops in ABJM theory in higher rank representations. Using standard matrix model techniques, we calculate the expectation value in the rank m fully symmetric and fully antisymmetric representation where m is scaled with N. To leading order, we find agreement with the classical action of D6 and D2 branes in AdS4 ×CP3 respectively. Further, we compute the first subleading order term, which, on the AdS side, makes a prediction for the one-loop effective action of the corresponding D6 and D2 branes. Supported by the National Science Foundation under Grant No. PHY 1559988 and the US Department of Energy under Grant No. DE-SC0007859.

Loop quantum corrected Einstein Yang-Mills black holes

NASA Astrophysics Data System (ADS)

Protter, Mason; DeBenedictis, Andrew

2018-05-01

In this paper, we study the homogeneous interiors of black holes possessing SU(2) Yang-Mills fields subject to corrections inspired by loop quantum gravity. The systems studied possess both magnetic and induced electric Yang-Mills fields. We consider the system of equations both with and without Wilson loop corrections to the Yang-Mills potential. The structure of the Yang-Mills Hamiltonian, along with the restriction to homogeneity, allows for an anomaly-free effective quantization. In particular, we study the bounce which replaces the classical singularity and the behavior of the Yang-Mills fields in the quantum corrected interior, which possesses topology R ×S2 . Beyond the bounce, the magnitude of the Yang-Mills electric field asymptotically grows monotonically. This results in an ever-expanding R sector even though the two-sphere volume is asymptotically constant. The results are similar with and without Wilson loop corrections on the Yang-Mills potential.

Cusp anomalous dimension and rotating open strings in AdS/CFT

NASA Astrophysics Data System (ADS)

Espíndola, R.; García, J. Antonio

2018-03-01

In the context of AdS/CFT we provide analytical support for the proposed duality between a Wilson loop with a cusp, the cusp anomalous dimension, and the meson model constructed from a rotating open string with high angular momentum. This duality was previously studied using numerical tools in [1]. Our result implies that the minimum of the profile function of the minimal area surface dual to the Wilson loop, is related to the inverse of the bulk penetration of the dual string that hangs from the quark-anti-quark pair (meson) in the gauge theory.

OPE for super loops

NASA Astrophysics Data System (ADS)

Sever, Amit; Vieira, Pedro; Wang, Tianheng

2011-11-01

We extend the Operator Product Expansion for Null Polygon Wilson loops to the Mason-Skinner-Caron-Huot super loop dual to non MHV gluon amplitudes. We explain how the known tree level amplitudes can be promoted into an infinite amount of data at any loop order in the OPE picture. As an application, we re-derive all one loop NMHV six gluon amplitudes by promoting their tree level expressions. We also present some new all loops predictions for these amplitudes.

Wilson loops in warped resolved deformed conifolds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Stephen, E-mail: pystephen@swansea.ac.uk

We calculate quark-antiquark potentials using the relationship between the expectation value of the Wilson loop and the action of a probe string in the string dual. We review and categorise the possible forms of the dependence of the energy on the separation between the quarks. In particular, we examine the possibility of there being a minimum separation for probe strings which do not penetrate close to the origin of the bulk space, and derive a condition which determines whether this is the case. We then apply these considerations to the flavoured resolved deformed conifold background of Gaillard et al. (2010)more » . We suggest that the unusual behaviour that we observe in this solution is likely to be related to the IR singularity which is not present in the unflavoured case. - Highlights: > We calculate quark-antiquark potentials using the Wilson loop and the action of a probe string in the string dual. > We review and categorise the possible forms of the dependence of the energy on the separation between the quarks. > We look in particular at the flavoured resolved deformed conifold. > There appears to be unusual behaviour which seems likely to be related to the IR singularity introduced by flavours.« less

Euclidean Wilson loops and minimal area surfaces in lorentzian AdS 3

DOE PAGES

Irrgang, Andrew; Kruczenski, Martin

2015-12-14

The AdS/CFT correspondence relates Wilson loops in N=4 SYM theory to minimal area surfaces in AdS 5 × S 5 space. If the Wilson loop is Euclidean and confined to a plane (t, x) then the dual surface is Euclidean and lives in Lorentzian AdS 3 c AdS 5. In this paper we study such minimal area surfaces generalizing previous results obtained in the Euclidean case. Since the surfaces we consider have the topology of a disk, the holonomy of the flat current vanishes which is equivalent to the condition that a certain boundary Schrödinger equation has all its solutionsmore » anti-periodic. If the potential for that Schrödinger equation is found then reconstructing the surface and finding the area become simpler. In particular we write a formula for the Area in terms of the Schwarzian derivative of the contour. Finally an infinite parameter family of analytical solutions using Riemann Theta functions is described. In this case, both the area and the shape of the surface are given analytically and used to check the previous results.« less

Wilson Lines and Webs in Higher-Order QCD

NASA Astrophysics Data System (ADS)

White, Chris D.

2018-03-01

Wilson lines have a number of uses in non-abelian gauge theories. A topical example in QCD is the description of radiation in the soft or collinear limit, which must often be resummed to all orders in perturbation theory. Correlators involving a pair of Wilson lines are known to exponentiate in terms of special Feynman diagrams called "webs". I will show how this language can be extended to an arbitrary number of Wilson lines, which introduces novel new combinatoric structures (web mixing matrices) of interest in their own right. I will also summarise recent results obtained from applying this formalism at three-loop order, before concluding with a list of open problems.

Diagrammatic exponentiation for products of Wilson lines

NASA Astrophysics Data System (ADS)

Mitov, Alexander; Sterman, George; Sung, Ilmo

2010-11-01

We provide a recursive diagrammatic prescription for the exponentiation of gauge theory amplitudes involving products of Wilson lines and loops. This construction generalizes the concept of webs, originally developed for eikonal form factors and cross sections with two eikonal lines, to general soft functions in QCD and related gauge theories. Our coordinate space arguments apply to arbitrary paths for the lines.

Half-BPS Wilson loop and AdS 2/CFT 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giombi, Simone; Roiban, Radu; Tseytlin, Arkady A.

Here, we study correlation functions of local operator insertions on the 1/2-BPS Wilson line in N=4 super Yang–Mills theory. These correlation functions are constrained by the 1d superconformal symmetry pre-served by the 1/2-BPS Wilson line and define a defect CFT 1 living on the line. At strong coupling, a set of elementary operator insertions with protected scaling dimensions correspond to fluctuations of the dual fundamental string in AdS 5×S 5 ending on the line at the boundary and can be thought of as light fields propagating on the AdS 2 worldsheet. We use AdS/CFT techniques to compute the tree-level AdSmore » 2 Witten diagrams describing the strong coupling limit of the four-point functions of the dual operator insertions. Using the OPE, we also extract the leading strong coupling corrections to the anomalous dimensions of the “two-particle” operators built out of elementary excitations. In the case of the circular Wilson loop, we match our results for the 4-point functions of a special type of scalar insertions to the prediction of localization to 2d Yang–Mills theory.« less

Half-BPS Wilson loop and AdS 2/CFT 1

DOE PAGES

Giombi, Simone; Roiban, Radu; Tseytlin, Arkady A.

2017-09-01

Here, we study correlation functions of local operator insertions on the 1/2-BPS Wilson line in N=4 super Yang–Mills theory. These correlation functions are constrained by the 1d superconformal symmetry pre-served by the 1/2-BPS Wilson line and define a defect CFT 1 living on the line. At strong coupling, a set of elementary operator insertions with protected scaling dimensions correspond to fluctuations of the dual fundamental string in AdS 5×S 5 ending on the line at the boundary and can be thought of as light fields propagating on the AdS 2 worldsheet. We use AdS/CFT techniques to compute the tree-level AdSmore » 2 Witten diagrams describing the strong coupling limit of the four-point functions of the dual operator insertions. Using the OPE, we also extract the leading strong coupling corrections to the anomalous dimensions of the “two-particle” operators built out of elementary excitations. In the case of the circular Wilson loop, we match our results for the 4-point functions of a special type of scalar insertions to the prediction of localization to 2d Yang–Mills theory.« less

Chern-Simons theory and Wilson loops in the Brillouin zone

NASA Astrophysics Data System (ADS)

Lian, Biao; Vafa, Cumrun; Vafa, Farzan; Zhang, Shou-Cheng

2017-03-01

Berry connection is conventionally defined as a static gauge field in the Brillouin zone. Here we show that for three-dimensional (3D) time-reversal invariant superconductors, a generalized Berry gauge field behaves as a fluctuating field of a Chern-Simons gauge theory. The gapless nodal lines in the momentum space play the role of Wilson loop observables, while their linking and knot invariants modify the gravitational theta angle. This angle induces a topological gravitomagnetoelectric effect where a temperature gradient induces a rotational energy flow. We also show how topological strings may be realized in the six-dimensional phase space, where the physical space defects play the role of topological D-branes.

Classical probes of string/gauge theory duality

NASA Astrophysics Data System (ADS)

Ishizeki, Riei

The AdS/CFT correspondence has played an important role in the recent development of string theory. The reason is that it proposes a description of certain gauge theories in terms of string theory. It is such that simple string theory computations give information about the strong coupling regime of the gauge theory. Vice versa, gauge theory computations give information about string theory and quantum gravity. Although much is known about AdS/CFT, the precise map between the two sides of the correspondence is not completely understood. In the unraveling of such map classical string solutions play a vital role. In this thesis, several classical string solutions are proposed to help understand the AdS/CFT duality. First, rigidly rotating strings on a two-sphere are studied. Taking special limits of such solutions leads to two cases: the already known giant magnon solution, and a new solution which we call the single spike solution. Next, we compute the scattering phase shift of the single spike solutions and compare the result with the giant magnon solutions. Intriguingly, the results are the same up to non-logarithmic terms, indicating that the single spike solution should have the same rich spin chain structure as the giant magnon solution. Afterward, we consider open string solutions ending on the boundary of AdS5. The lines traced by the ends of such open strings can be viewed as Wilson loops in N = 4 SYM theory. After applying an inversion transformation, the open Wilson loops become closed Wilson loops whose expectation value is consistent with previously conjectured results. Next, several Wilson loops for N = 4 SYM in an AdS5 pp-wave background are considered and translated to the pure AdS 5 background and their interpretation as forward quark-gluon scattering is suggested. In the last part of this thesis, a class of classical solutions for closed strings moving in AdS3 x S 1 ⊂ AdS5 x S5 with energy E and spin S in AdS3 and angular momentum J and winding m in S1 is explained. The relation between different limits of the spiky string solution with the Landau-Lifshitz model is of particular interest. The presented solutions provide new classes of string motion that are used to better understand the AdS/CFT correspondence, including the single spike solution and previously unknown examples of supersymmetric Wilson loops.

ABJM Wilson loops in arbitrary representations

NASA Astrophysics Data System (ADS)

Hatsuda, Yasuyuki; Honda, Masazumi; Moriyama, Sanefumi; Okuyama, Kazumi

2013-10-01

We study vacuum expectation values (VEVs) of circular half BPS Wilson loops in arbitrary representations in ABJM theory. We find that those in hook representations are reduced to elementary integrations thanks to the Fermi gas formalism, which are accessible from the numerical studies similar to the partition function in the previous studies. For non-hook representations, we show that the VEVs in the grand canonical formalism can be exactly expressed as determinants of those in the hook representations. Using these facts, we can study the instanton effects of the VEVs in various representations. Our results are consistent with the worldsheet instanton effects studied from the topological string and a prescription to include the membrane instanton effects by shifting the chemical potential, which has been successful for the partition function.

Cyclic softening based on dislocation annihilation at sub-cell boundary for SA333 Grade-6 C-Mn steel

NASA Astrophysics Data System (ADS)

Bhattacharjee, S.; Dhar, S.; Acharyya, S. K.; Gupta, S. K.

2018-01-01

In this work, the response of SA333 Grade-6 C-Mn steel subjected to uniaxial and in-phase biaxial tension-torsion cyclic loading is experimented and an attempt is made to model the material behaviour. Experimentally observed cyclic softening is modelled based on ‘dislocation annihilation at low angle grain boundary’, while Ohno-Wang kinematic hardening rule is used to simulate the stress-strain hysteresis loops. The relevant material parameters are extracted from the appropriate experimental results and metallurgical investigations. The material model is plugged as user material subroutine into ABAQUS FE platform to simulate pre-saturation low cycle fatigue loops with cyclic softening and other cyclic plastic behaviour under prescribed loading. The stress-strain hysteresis loops and peak stress with cycles were compared with the experimental results and good agreements between experimental and simulated results validated the material model.

Supercycles, Wilson cycles and the future of Earth's oceans

NASA Astrophysics Data System (ADS)

Duarte, Joao; Schellart, Wouter; Rosas, Filipe

2014-05-01

At the dawn of the 20th Century Alfred Wegener proposed the existence of a supercontinent - Pangaea - gathering all the continental masses on Earth. Five decades later, while seeding the theory of plate tectonics, Tuzo Wilson introduced a new concept that would become known as Wilson cycles, which describes the evolution of oceans: 1) opening and spreading, 2) foundering of the passive margins and development of new subduction zones and 3) consumption and closure. Later on, in the 70's evidences for the existence of a number of other supercontinents and ancient oceans on Earth's history started to emerge. Today, concepts like supercycles, supercontinents, superoceans and Wilson cycles are loosely used. However, several important questions remain. How do subduction zones initiate in pristine oceans? Which major ocean on Earth will close to form the next supercontinent? The Atlantic (introversion), the Pacific (extroversion), or both? Are Wilson cycles of lower order than Supercycles? Are we in an abnormally long supercycle? Is there any cyclicity at all? These are some of the questions that we will tentatively address together with the proposal of several future scenarios for the evolution of Earth's oceans and continents.

Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop

PubMed Central

Upert, Gregory; Di Giorgio, Audrey; Upadhyay, Alok; Manvar, Dinesh; Pandey, Nootan; Pandey, Virendra N.; Patino, Nadia

2012-01-01

Human immunodeficiency virus-1 (HIV-1) replication and gene expression entails specific interaction of the viral protein Tat with its transactivation responsive element (TAR), to form a highly stable stem-bulge-loop structure. Previously, we described triphenylphosphonium (TPP) cation-based vectors that efficiently deliver nucleotide analogs (PNAs) into the cytoplasm of cells. In particular, we showed that the TPP conjugate of a linear 16-mer PNA targeting the apical stem-loop region of TAR impedes Tat-mediated transactivation of the HIV-1 LTR in vitro and also in cell culture systems. In this communication, we conjugated TPP to cyclic and hairpin PNAs targeting the loop region of HIV-1 TAR and evaluated their antiviral efficacy in a cell culture system. We found that TPP-cyclic PNAs containing only 8 residues, showed higher antiviral potency compared to hairpin PNAs of 12 or 16 residues. We further noted that the TPP-conjugates of the 8-mer cyclic PNA as well as the 16-mer linear PNA displayed similar antiviral efficacy. However, cyclic PNAs were shown to be highly specific to their target sequences. This communication emphasizes on the importance of small constrained cyclic PNAs over both linear and hairpin structures for targeting biologically relevant RNA hairpins. PMID:23029603

A lattice approach to spinorial quantum gravity

NASA Technical Reports Server (NTRS)

Renteln, Paul; Smolin, Lee

1989-01-01

A new lattice regularization of quantum general relativity based on Ashtekar's reformulation of Hamiltonian general relativity is presented. In this form, quantum states of the gravitational field are represented within the physical Hilbert space of a Kogut-Susskind lattice gauge theory. The gauge field of the theory is a complexified SU(2) connection which is the gravitational connection for left-handed spinor fields. The physical states of the gravitational field are those which are annihilated by additional constraints which correspond to the four constraints of general relativity. Lattice versions of these constraints are constructed. Those corresponding to the three-dimensional diffeomorphism generators move states associated with Wilson loops around on the lattice. The lattice Hamiltonian constraint has a simple form, and a correspondingly simple interpretation: it is an operator which cuts and joins Wilson loops at points of intersection.

Non-local order in Mott insulators, duality and Wilson loops

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rath, Steffen Patrick, E-mail: steffen.rath@ph.tum.de; Simeth, Wolfgang; Endres, Manuel

2013-07-15

It is shown that the Mott insulating and superfluid phases of bosons in an optical lattice may be distinguished by a non-local ‘parity order parameter’ which is directly accessible via single site resolution imaging. In one dimension, the lattice Bose model is dual to a classical interface roughening problem. We use known exact results from the latter to prove that the parity order parameter exhibits long range order in the Mott insulating phase, consistent with recent experiments by Endres et al. [M. Endres, M. Cheneau, T. Fukuhara, C. Weitenberg, P. Schauß, C. Gross, L. Mazza, M.C. Bañuls, L. Pollet, I.more » Bloch, et al., Science 334 (2011) 200]. In two spatial dimensions, the parity order parameter can be expressed in terms of an equal time Wilson loop of a non-trivial U(1) gauge theory in 2+1 dimensions which exhibits a transition between a Coulomb and a confining phase. The negative logarithm of the parity order parameter obeys a perimeter law in the Mott insulator and is enhanced by a logarithmic factor in the superfluid. -- Highlights: •Number statistics of cold atoms in optical lattices show non-local correlations. •These correlations are measurable via single site resolution imaging. •Incompressible phases exhibit an area law in particle number fluctuations. •This leads to long-range parity order of Mott-insulators in one dimension. •Parity order in 2d is connected with a Wilson-loop in a lattice gauge theory.« less

Spatially-protected Topology and Group Cohomology in Band Insulators

NASA Astrophysics Data System (ADS)

Alexandradinata, A.

This thesis investigates band topologies which rely fundamentally on spatial symmetries. A basic geometric property that distinguishes spatial symmetry regards their transformation of the spatial origin. Point groups consist of spatial transformations that preserve the spatial origin, while un-split extensions of the point groups by spatial translations are referred to as nonsymmorphic space groups. The first part of the thesis addresses topological phases with discretely-robust surface properties: we introduce theories for the Cnv point groups, as well as certain nonsymmorphic groups that involve glide reflections. These band insulators admit a powerful characterization through the geometry of quasimomentum space; parallel transport in this space is represented by the Wilson loop. The non-symmorphic topology we study is naturally described by a further extension of the nonsymmorphic space group by quasimomentum translations (the Wilson loop), thus placing real and quasimomentum space on equal footing -- here, we introduce the language of group cohomology into the theory of band insulators. The second part of the thesis addresses topological phases without surface properties -- their only known physical consequences are discrete signatures in parallel transport. We provide two such case studies with spatial-inversion and discrete-rotational symmetries respectively. One lesson learned here regards the choice of parameter loops in which we carry out transport -- the loop must be chosen to exploit the symmetry that protects the topology. While straight loops are popular for their connection with the geometric theory of polarization, we show that bent loops also have utility in topological band theory.

Lattice corrections to the quark quasidistribution at one loop

DOE PAGES

Carlson, Carl E.; Freid, Michael

2017-05-12

Here, we calculate radiative corrections to the quark quasidistribution in lattice perturbation theory at one loop to leading orders in the lattice spacing. We also consider one-loop corrections in continuum Euclidean space. We find that the infrared behavior of the corrections in Euclidean and Minkowski space are different. Furthermore, we explore features of momentum loop integrals and demonstrate why loop corrections from the lattice perturbation theory and Euclidean continuum do not correspond with their Minkowski brethren, and comment on a recent suggestion for transcending the differences in the results. Finally, we examine the role of the lattice spacing a andmore » of the r parameter in the Wilson action in these radiative corrections.« less

Lattice corrections to the quark quasidistribution at one loop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, Carl E.; Freid, Michael

Here, we calculate radiative corrections to the quark quasidistribution in lattice perturbation theory at one loop to leading orders in the lattice spacing. We also consider one-loop corrections in continuum Euclidean space. We find that the infrared behavior of the corrections in Euclidean and Minkowski space are different. Furthermore, we explore features of momentum loop integrals and demonstrate why loop corrections from the lattice perturbation theory and Euclidean continuum do not correspond with their Minkowski brethren, and comment on a recent suggestion for transcending the differences in the results. Finally, we examine the role of the lattice spacing a andmore » of the r parameter in the Wilson action in these radiative corrections.« less

Perturbative two- and three-loop coefficients from large β Monte Carlo

NASA Astrophysics Data System (ADS)

Lepage, G. P.; Mackenzie, P. B.; Shakespeare, N. H.; Trottier, H. D.

Perturbative coefficients for Wilson loops and the static quark self-energy are extracted from Monte Carlo simulations at large β on finite volumes, where all the lattice momenta are large. The Monte Carlo results are in excellent agreement with perturbation theory through second order. New results for third order coefficients are reported. Twisted boundary conditions are used to eliminate zero modes and to suppress Z3 tunneling.

Perturbative two- and three-loop coefficients from large b Monte Carlo

DOE Office of Scientific and Technical Information (OSTI.GOV)

G.P. Lepage; P.B. Mackenzie; N.H. Shakespeare

1999-10-18

Perturbative coefficients for Wilson loops and the static quark self-energy are extracted from Monte Carlo simulations at large {beta} on finite volumes, where all the lattice momenta are large. The Monte Carlo results are in excellent agreement with perturbation theory through second order. New results for third order coefficients are reported. Twisted boundary conditions are used to eliminate zero modes and to suppress Z{sub 3} tunneling.

Confronting effective models for deconfinement in dense quark matter with lattice data

NASA Astrophysics Data System (ADS)

Andersen, Jens O.; Brauner, Tomáš; Naylor, William R.

2015-12-01

Ab initio numerical simulations of the thermodynamics of dense quark matter remain a challenge. Apart from the infamous sign problem, lattice methods have to deal with finite volume and discretization effects as well as with the necessity to introduce sources for symmetry-breaking order parameters. We study these artifacts in the Polyakov-loop-extended Nambu-Jona-Lasinio (PNJL) model and compare its predictions to existing lattice data for cold and dense two-color matter with two flavors of Wilson quarks. To achieve even qualitative agreement with lattice data requires the introduction of two novel elements in the model: (i) explicit chiral symmetry breaking in the effective contact four-fermion interaction, referred to as the chiral twist, and (ii) renormalization of the Polyakov loop. The feedback of the dense medium to the gauge sector is modeled by a chemical-potential-dependent scale in the Polyakov-loop potential. In contrast to previously used analytical Ansätze, we determine its dependence on the chemical potential from lattice data for the expectation value of the Polyakov loop. Finally, we propose adding a two-derivative operator to our effective model. This term acts as an additional source of explicit chiral symmetry breaking, mimicking an analogous term in the lattice Wilson action.

Phase of the Wilson line at high temperature in the standard model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korthals Altes, C.P.; Lee, K.; Pisarski, R.D.

1994-09-26

We compute the effective potential for the phase of the Wilson line at high temperature in the standard model to one-loop order. Besides the trivial vacua, there are metastable states in the direction of U(1) hypercharge. Assuming that the Universe starts out in such a metastable state at the Planck scale, it easily persists to the time of the electroweak phase transition, which then proceeds by an unusual mechanism. All remnants of the metastable state evaporate about the time of the QCD phase transition.

Subleading Regge limit from a soft anomalous dimension

NASA Astrophysics Data System (ADS)

Brüser, Robin; Caron-Huot, Simon; Henn, Johannes M.

2018-04-01

Wilson lines capture important features of scattering amplitudes, for example soft effects relevant for infrared divergences, and the Regge limit. Beyond the leading power approximation, corrections to the eikonal picture have to be taken into account. In this paper, we study such corrections in a model of massive scattering amplitudes in N=4 super Yang-Mills, in the planar limit, where the mass is generated through a Higgs mechanism. Using known three-loop analytic expressions for the scattering amplitude, we find that the first power suppressed term has a very simple form, equal to a single power law. We propose that its exponent is governed by the anomalous dimension of a Wilson loop with a scalar inserted at the cusp, and we provide perturbative evidence for this proposal. We also analyze other limits of the amplitude and conjecture an exact formula for a total cross-section at high energies.

QCD Condensates and Holographic Wilson Loops for Asymptotically AdS Spaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quevedo, R. Carcasses; Goity, Jose L.; Trinchero, Roberto C.

2014-02-01

The minimization of the Nambu-Goto (NG) action for a surface whose contour defines a circular Wilson loop of radius a placed at a finite value of the coordinate orthogonal to the border is considered. This is done for asymptotically AdS spaces. The condensates of dimension n = 2, 4, 6, 8, and 10 are calculated in terms of the coefficients in the expansion in powers of the radius a of the on-shell subtracted NG action for small a->0. The subtraction employed is such that it presents no conflict with conformal invariance in the AdS case and need not introduce anmore » additional infrared scale for the case of confining geometries. It is shown that the UV value of the gluon condensates is universal in the sense that it only depends on the first coefficients of the difference with the AdS case.« less

Investigation of Stress-Strain History Modeling at Stress Risers

DTIC Science & Technology

1977-06-01

GJ6(A ’/2 = 0.0149) 21 7 Hysteresis Loops for Test GJ9(A f/2 = 0.0211) 22 8 Hysteresis Loops for Test GJI (6 ir/2 = 0.0294) 23 9 Cyclic and Monotonic...61 Hysteresis Loops for Test GJ9(A c/2=0.021 1) 105 62 Hysteresis Loops for Test GJI (At/2=0.0294) 106 63 Cyclic Locus Curve 107 64 Stable Hysteresis...tests GJI through GJ37 show that 7075-T651 aluminum both hardens and softens. The response ]or four of these tests is plotted in Figures 59 through 62

Mad Tea Party Cyclic Partitions

ERIC Educational Resources Information Center

Bekes, Robert; Pedersen, Jean; Shao, Bin

2012-01-01

Martin Gardner's "The Annotated Alice," and Robin Wilson's "Lewis Carroll in Numberland" led the authors to put this article in a fantasy setting. Alice, the March Hare, the Hatter, and the Dormouse describe a straightforward, elementary algorithm for counting the number of ways to fit "n" identical objects into "k" cups arranged in a circle. The…

Quark confinement: Dual superconductor picture based on a non-Abelian Stokes theorem and reformulations of Yang-Mills theory

NASA Astrophysics Data System (ADS)

Kondo, Kei-Ichi; Kato, Seikou; Shibata, Akihiro; Shinohara, Toru

2015-05-01

The purpose of this paper is to review the recent progress in understanding quark confinement. The emphasis of this review is placed on how to obtain a manifestly gauge-independent picture for quark confinement supporting the dual superconductivity in the Yang-Mills theory, which should be compared with the Abelian projection proposed by 't Hooft. The basic tools are novel reformulations of the Yang-Mills theory based on change of variables extending the decomposition of the SU(N) Yang-Mills field due to Cho, Duan-Ge and Faddeev-Niemi, together with the combined use of extended versions of the Diakonov-Petrov version of the non-Abelian Stokes theorem for the SU(N) Wilson loop operator. Moreover, we give the lattice gauge theoretical versions of the reformulation of the Yang-Mills theory which enables us to perform the numerical simulations on the lattice. In fact, we present some numerical evidences for supporting the dual superconductivity for quark confinement. The numerical simulations include the derivation of the linear potential for static interquark potential, i.e., non-vanishing string tension, in which the "Abelian" dominance and magnetic monopole dominance are established, confirmation of the dual Meissner effect by measuring the chromoelectric flux tube between quark-antiquark pair, the induced magnetic-monopole current, and the type of dual superconductivity, etc. In addition, we give a direct connection between the topological configuration of the Yang-Mills field such as instantons/merons and the magnetic monopole. We show especially that magnetic monopoles in the Yang-Mills theory can be constructed in a manifestly gauge-invariant way starting from the gauge-invariant Wilson loop operator and thereby the contribution from the magnetic monopoles can be extracted from the Wilson loop in a gauge-invariant way through the non-Abelian Stokes theorem for the Wilson loop operator, which is a prerequisite for exhibiting magnetic monopole dominance for quark confinement. The Wilson loop average is calculated according to the new reformulation written in terms of new field variables obtained from the original Yang-Mills field based on change of variables. The Maximally Abelian gauge in the original Yang-Mills theory is also reproduced by taking a specific gauge fixing in the reformulated Yang-Mills theory. This observation justifies the preceding results obtained in the maximal Abelian gauge at least for gauge-invariant quantities for SU(2) gauge group, which eliminates the criticism of gauge artifact raised for the Abelian projection. The claim has been confirmed based on the numerical simulations. However, for SU(N) (N ≥ 3), such a gauge-invariant reformulation is not unique, although the extension along the line proposed by Cho, Faddeev and Niemi is possible. In fact, we have found that there are a number of possible options of the reformulations, which are discriminated by the maximal stability group H ˜ of G, while there is a unique option of H ˜ = U(1) for G = SU(2) . The maximal stability group depends on the representation of the gauge group, to that the quark source belongs. For the fundamental quark for SU(3) , the maximal stability group is U(2) , which is different from the maximal torus group U(1) × U(1) suggested from the Abelian projection. Therefore, the chromomagnetic monopole inherent in the Wilson loop operator responsible for confinement of quarks in the fundamental representation for SU(3) is the non-Abelian magnetic monopole, which is distinct from the Abelian magnetic monopole for the SU(2) case. Therefore, we claim that the mechanism for quark confinement for SU(N) (N ≥ 3) is the non-Abelian dual superconductivity caused by condensation of non-Abelian magnetic monopoles. We give some theoretical considerations and numerical results supporting this picture. Finally, we discuss some issues to be investigated in future studies.

Study on stress-strain response of multi-phase TRIP steel under cyclic loading

NASA Astrophysics Data System (ADS)

Dan, W. J.; Hu, Z. G.; Zhang, W. G.; Li, S. H.; Lin, Z. Q.

2013-12-01

The stress-strain response of multi-phase TRIP590 sheet steel is studied in cyclic loading condition at room temperature based on a cyclic phase transformation model and a multi-phase mixed kinematic hardening model. The cyclic martensite transformation model is proposed based on the shear-band intersection, where the repeat number, strain amplitude and cyclic frequency are used to control the phase transformation process. The multi-phase mixed kinematic hardening model is developed based on the non-linear kinematic hardening rule of per-phase. The parameters of transformation model are identified with the relationship between the austenite volume fraction and the repeat number. The parameters in Kinematic hardening model are confirmed by the experimental hysteresis loops in different strain amplitude conditions. The responses of hysteresis loop and stress amplitude are evaluated by tension-compression data.

Infrared singularities of scattering amplitudes in perturbative QCD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becher, Thomas; Neubert, Matthias

2013-11-01

An exact formula is derived for the infrared singularities of dimensionally regularized scattering amplitudes in massless QCD with an arbitrary number of legs, valid at any number of loops. It is based on the conjecture that the anomalous-dimension matrix of n-jet operators in soft-collinear effective theory contains only a single non-trivial color structure, whose coefficient is the cusp anomalous dimension of Wilson loops with light-like segments. Its color-diagonal part is characterized by two anomalous dimensions, which are extracted to three-loop order from known perturbative results for the quark and gluon form factors. This allows us to predict the three-loop coefficientsmore » of all 1/epsilon^k poles for an arbitrary n-parton scattering amplitudes, generalizing existing two-loop results.« less

Liver failure with coagulopathy, hyperammonemia and cyclic vomiting in a toddler revealed to have combined heterozygosity for genes involved with ornithine transcarbamylase deficiency and Wilson disease.

PubMed

Mira, Valerie; Boles, Richard G

2012-01-01

A girl with a 2 month history of cyclic episodes of vomiting, diarrhea, and lethargy lasting 2-3 days each presented with acute hepatopathy (ALT 3,500 IU/L) with coagulopathy (PT 55 s) and hyperammonemia (207 μmol/L) at age 1½ years. Biochemical and molecular analyzes revealed ornithine transcarbamylase (OTC) deficiency. While laboratory signs of mild hepatocellular dysfunction are common in OTC deficiency, substantial liver failure with coagulopathy is generally not seen, although four others cases have been reported, three of which presented with cyclic vomiting. Further evaluation in our case revealed elevated urine (198.8 μg/g creatinine) and liver (103 μg/g dry weight) copper content, and a heterozygous mutation in the Wilson disease gene, ATP7B. Our patient, now aged 5 years, has remained in excellent health with normal growth and development on fasting avoidance, a modified vegan diet, and sodium phenylbutyrate.These five cases demonstrate that generalized liver dysfunction/failure is a potential serious complication of OTC deficiency, although not a common one, and suggests that an ALT and PT should be obtained in OTC patients during episodes of hyperammonemia. Cyclic vomiting is a known presentation of OTC deficiency; it is not known if comorbid liver failure predisposes toward this phenotype. We propose that the heterozygote state in ATP7B increases the liver copper content, thus predisposing our patient with OTC deficiency to develop liver failure during a hyperammonemic episode. Our present case is an example of the opportunity of molecular diagnostics to identify putative modifier genes in patients with atypical presentations of genetic disorders.

Conical twist fields and null polygonal Wilson loops

NASA Astrophysics Data System (ADS)

Castro-Alvaredo, Olalla A.; Doyon, Benjamin; Fioravanti, Davide

2018-06-01

Using an extension of the concept of twist field in QFT to space-time (external) symmetries, we study conical twist fields in two-dimensional integrable QFT. These create conical singularities of arbitrary excess angle. We show that, upon appropriate identification between the excess angle and the number of sheets, they have the same conformal dimension as branch-point twist fields commonly used to represent partition functions on Riemann surfaces, and that both fields have closely related form factors. However, we show that conical twist fields are truly different from branch-point twist fields. They generate different operator product expansions (short distance expansions) and form factor expansions (large distance expansions). In fact, we verify in free field theories, by re-summing form factors, that the conical twist fields operator product expansions are correctly reproduced. We propose that conical twist fields are the correct fields in order to understand null polygonal Wilson loops/gluon scattering amplitudes of planar maximally supersymmetric Yang-Mills theory.

Improved quasi parton distribution through Wilson line renormalization

DOE PAGES

Chen, Jiunn-Wei; Ji, Xiangdong; Zhang, Jian-Hui

2016-12-09

Some recent developments showed that hadron light-cone parton distributions could be directly extracted from spacelike correlators, known as quasi parton distributions, in the large hadron momentum limit. Unlike the normal light-cone parton distribution, a quasi parton distribution contains ultraviolet (UV) power divergence associated with the Wilson line self energy. Here, we show that to all orders in the coupling expansion, the power divergence can be removed by a “mass” counterterm in the auxiliary z-field formalism, in the same way as the renormalization of power divergence for an open Wilson line. After adding this counterterm, the quasi quark distribution is improvedmore » such that it contains at most logarithmic divergences. Based on a simple version of discretized gauge action, we also present the one-loop matching kernel between the improved non-singlet quasi quark distribution with a lattice regulator and the corresponding quark distribution in dimensional regularization.« less

Improved quasi parton distribution through Wilson line renormalization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Jiunn-Wei; Ji, Xiangdong; Zhang, Jian-Hui

Some recent developments showed that hadron light-cone parton distributions could be directly extracted from spacelike correlators, known as quasi parton distributions, in the large hadron momentum limit. Unlike the normal light-cone parton distribution, a quasi parton distribution contains ultraviolet (UV) power divergence associated with the Wilson line self energy. Here, we show that to all orders in the coupling expansion, the power divergence can be removed by a “mass” counterterm in the auxiliary z-field formalism, in the same way as the renormalization of power divergence for an open Wilson line. After adding this counterterm, the quasi quark distribution is improvedmore » such that it contains at most logarithmic divergences. Based on a simple version of discretized gauge action, we also present the one-loop matching kernel between the improved non-singlet quasi quark distribution with a lattice regulator and the corresponding quark distribution in dimensional regularization.« less

Noncommutative Wilson lines in higher-spin theory and correlation functions of conserved currents for free conformal fields

NASA Astrophysics Data System (ADS)

Bonezzi, Roberto; Boulanger, Nicolas; De Filippi, David; Sundell, Per

2017-11-01

We first prove that, in Vasiliev’s theory, the zero-form charges studied in Sezgin E and Sundell P 2011 (arXiv:1103.2360 [hep-th]) and Colombo N and Sundell P 20 (arXiv:1208.3880 [hep-th]) are twisted open Wilson lines in the noncommutative Z space. This is shown by mapping Vasiliev’s higher-spin model on noncommutative Yang-Mills theory. We then prove that, prior to Bose-symmetrising, the cyclically-symmetric higher-spin invariants given by the leading order of these n-point zero-form charges are equal to corresponding cyclically-invariant building blocks of n-point correlation functions of bilinear operators in free conformal field theories (CFT) in three dimensions. On the higher spin gravity side, our computation reproduces the results of Didenko V and Skvortsov E 2013 J. High Energy Phys. JHEP04(2013)158 using an alternative method amenable to the computation of subleading corrections obtained by perturbation theory in normal order. On the free CFT side, our proof involves the explicit computation of the separate cyclic building blocks of the correlation functions of n conserved currents in arbitrary dimension d>2 using polarization vectors, which is an original result. It is shown to agree, for d=3 , with the results obtained in Gelfond O A and Vasiliev M A 2013 Nucl. Phys. B 876 871-917 in various dimensions and where polarization spinors were used.

Cyclic growth in Atlantic region continental crust

NASA Technical Reports Server (NTRS)

Goodwin, A. M.

1986-01-01

Atlantic region continental crust evolved in successive stages under the influence of regular, approximately 400 Ma-long tectonic cycles. Data point to a variety of operative tectonic processes ranging from widespread ocean floor consumption (Wilson cycle) to entirely ensialic (Ampferer-style subduction or simple crustal attenuation-compression). Different processes may have operated concurrently in some or different belts. Resolving this remains the major challenge.

Relating quark confinement and chiral symmetry breaking in QCD

NASA Astrophysics Data System (ADS)

Suganuma, Hideo; Doi, Takahiro M.; Redlich, Krzysztof; Sasaki, Chihiro

2017-12-01

We study the relation between quark confinement and chiral symmetry breaking in QCD. Using lattice QCD formalism, we analytically express the various ‘confinement indicators’, such as the Polyakov loop, its fluctuations, the Wilson loop, the inter-quark potential and the string tension, in terms of the Dirac eigenmodes. In the Dirac spectral representation, there appears a power of the Dirac eigenvalue {λ }n such as {λ }n{Nt-1}, which behaves as a reduction factor for small {λ }n. Consequently, since this reduction factor cannot be cancelled, the low-lying Dirac eigenmodes give negligibly small contribution to the confinement quantities, while they are essential for chiral symmetry breaking. These relations indicate that there is no direct one-to-one correspondence between confinement and chiral symmetry breaking in QCD. In other words, there is some independence of quark confinement from chiral symmetry breaking, which can generally lead to different transition temperatures/densities for deconfinement and chiral restoration. We also investigate the Polyakov loop in terms of the eigenmodes of the Wilson, the clover and the domain-wall fermion kernels, and find similar results. The independence of quark confinement from chiral symmetry breaking seems to be natural, because confinement is realized independently of quark masses and heavy quarks are also confined even without the chiral symmetry.

High Temperature Fatigue Properties Research of GH4169 under Multiaxial Cyclic Loading

NASA Astrophysics Data System (ADS)

Ma, Shaojun; Tong, Dihua; Li, Liyun; Cheng, Yangyang; Hu, Benrun; Chen, Bo

2018-03-01

The high temperature (550°C and 650°C) fatigue properties of GH4169 for thin-wall tube specimen are investigated under uniaxial tension, uniaxial torsion, proportional tension-torsion and nonproportional tension-torsion. All tests are strain-controlled. The results indicate that the shape of the hysteresis loops of uniaxial tension, uniaxial torsion and proportional tension-torsion are similar, but hysteresis loop of non-proportional tension-torsion has distortion; the cyclic softening behavior is shown for GH4169 under uniaxial tension, uniaxial torsion and proportional tension-torsion, but the cyclic hardening behavior is shown for the first several cycles of nonproportional tension-torsion.

Flexor Tendon Repair With Looped Suture: 1 Versus 2 Knots.

PubMed

Gil, Joseph A; Skjong, Christian; Katarincic, Julia A; Got, Christopher

2016-03-01

To assess the strength of flexor tendon repair with looped suture. We hypothesized that, after passing the intact looped suture in the desired repair configuration, splitting the loop and tying 2 independent knots would increase the strength of flexor tendon repair. Thirty-two flexor tendons were harvested and were sharply transected in zone II. The tendons were repaired with a 4-strand core suture repair using 3-0 looped nonabsorbable nylon suture. The harvested tendons were randomly assigned and repaired with either a 1- or a 2-knot construct. The repaired flexor tendons were fixed in a servohydraulic material testing system and were loaded to failure either with uniaxial tension or cyclically. The average force at failure was 43 N for the 1-knot repair and 28 N for the 2-knot repair. The mode of failure of 15 of the flexor tendon repairs that were cyclically loaded to failure was suture pull-out. The average number of cycles and force in cyclic testing that caused failure of flexor tendon repairs was 134 cycles and 31 N for tendons repaired with looped 3-0 suture tied with 1 knot and 94 cycles and 33 N for tendons repaired with looped 3-0 suture tied with 2 knots. Our hypothesis was disproved by the results of this study. This study suggests that, when using looped suture, tying 2 independent knots instead of tying a single knot does not increase the strength of the flexor tendon repair. Copyright © 2016 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Further evidence for a sub-year magnetic chromospheric activity cycle and activity phase jumps in the planet host τ Boötis

NASA Astrophysics Data System (ADS)

Schmitt, J. H. M. M.; Mittag, M.

2017-04-01

We examine the S-index data, obtained in the context of the Mount Wilson H&K project for the nearby F-type star τ Boo, for the presence of possible cyclic variations on timescales below one year and "phase jump" episodes in the observed S-index activity levels, to determine whether such features are persistent properties of the chromospheric activity of τ Boo and possibly other late-type stars. Within the Mount Wilson H&K project τ Boo was observed during 1278 individual nights, albeit with a very inhomogeneous coverage ranging from 2 to 137 observations per year. Our analysis shows that periodical variations with timescales on the order of 110-120 days are a persistent feature of the Mount Wilson data set. Furthermore we provide further examples of "phase jump" episodes, when the observed S-index activity drops from maximum to minimum levels on timescales of one to two weeks, hence such features also appear to occur on a more or less regular basis in τ Boo.

Connected and disconnected contributions to nucleon axial form factors using Nf = 2 twisted mass fermions at the physical point

NASA Astrophysics Data System (ADS)

Alexandrou, Constantia; Constantinou, Martha; Hadjiyiannakou, Kyriakos; Jansen, Karl; Kallidonis, Christos; Koutsou, Giannis; Vaquero Avilés-Casco, Alejandro

2018-03-01

We present results on the isovector and isoscalar nucleon axial form factors including disconnected contributions, using an ensemble of Nf = 2 twisted mass cloverimproved Wilson fermions simulated with approximately the physical value of the pion mass. The light disconnected quark loops are computed using exact deflation, while the strange and the charm quark loops are evaluated using the truncated solver method. Techniques such as the summation and the two-state fits have been employed to access ground-state dominance.

Loop Variables in String Theory

NASA Astrophysics Data System (ADS)

Sathiapalan, B.

The loop variable approach is a proposal for a gauge-invariant generalization of the sigma-model renormalization group method of obtaining equations of motion in string theory. The basic guiding principle is space-time gauge invariance rather than world sheet properties. In essence it is a version of Wilson's exact renormalization group equation for the world sheet theory. It involves all the massive modes and is defined with a finite world sheet cutoff, which allows one to go off the mass-shell. On shell the tree amplitudes of string theory are reproduced. The equations are gauge-invariant off shell also. This paper is a self-contained discussion of the loop variable approach as well as its connection with the Wilsonian RG.

When does the gluon reggeize?

NASA Astrophysics Data System (ADS)

Caron-Huot, Simon

2015-05-01

We propose the eikonal approximation as a simple and reliable tool to analyze relativistic high-energy processes, provided that the necessary subtleties are accounted for. An important subtlety is the need to include eikonal phases for a rapidity-dependent collection of particles, as embodied by the Balitsky-JIMWLK rapidity evolution equation. In the first part of this paper, we review how the phenomenon of gluon reggeization and the BFKL equations can be understood simply (but not too simply) in the eikonal approach. We also work out some previously overlooked implications of BFKL dynamics, including the observation that starting from four loops it is incompatible with a recent conjecture regarding the structure of infrared divergences. In the second part of this paper, we propose that in the strict planar limit the theory can be developed to all orders in the coupling with no reference at all to the concept of "reggeized gluon." Rather, one can work directly with a finite, process-dependent, number of Wilson lines. We demonstrate consistency of this proposal by an exact computation in N=4 super Yang-Mills, which shows that in processes mediated with two Wilson lines the reggeized gluon appears in the weak coupling limit as a resonance whose width is proportional to the coupling. We also provide a precise operator definition of Lipatov's integrable spin chain, which is manifestly integrable at any value of the coupling as a result of the duality between scattering amplitudes and Wilson loops in this theory.

Wilson loops on Riemann surfaces, Liouville theory and covariantization of the conformal group

NASA Astrophysics Data System (ADS)

Matone, Marco; Pasti, Paolo

2015-06-01

The covariantization procedure is usually referred to the translation operator, that is the derivative. Here we introduce a general method to covariantize arbitrary differential operators, such as the ones defining the fundamental group of a given manifold. We focus on the differential operators representing the sl2(ℝ) generators, which in turn, generate, by exponentiation, the two-dimensional conformal transformations. A key point of our construction is the recent result on the closed forms of the Baker-Campbell-Hausdorff formula. In particular, our covariantization receipt is quite general. This has a deep consequence since it means that the covariantization of the conformal group is always definite. Our covariantization receipt is quite general and apply in general situations, including AdS/CFT. Here we focus on the projective unitary representations of the fundamental group of a Riemann surface, which may include elliptic points and punctures, introduced in the framework of noncommutative Riemann surfaces. It turns out that the covariantized conformal operators are built in terms of Wilson loops around Poincaré geodesics, implying a deep relationship between gauge theories on Riemann surfaces and Liouville theory.

Wilson loops and chiral correlators on squashed spheres

NASA Astrophysics Data System (ADS)

Fucito, F.; Morales, J. F.; Poghossian, R.

2015-11-01

We study chiral deformations of N=2 and N=4 supersymmetric gauge theories obtained by turning on τ J tr Φ J interactions with Φ the N=2 superfield. Using localization, we compute the deformed gauge theory partition function Z(overrightarrow{τ}|q) and the expectation value of circular Wilson loops W on a squashed four-sphere. In the case of the deformed {N}=4 theory, exact formulas for Z and W are derived in terms of an underlying U( N) interacting matrix model replacing the free Gaussian model describing the {N}=4 theory. Using the AGT correspondence, the τ J -deformations are related to the insertions of commuting integrals of motion in the four-point CFT correlator and chiral correlators are expressed as τ-derivatives of the gauge theory partition function on a finite Ω-background. In the so called Nekrasov-Shatashvili limit, the entire ring of chiral relations is extracted from the ɛ-deformed Seiberg-Witten curve. As a byproduct of our analysis we show that SU(2) gauge theories on rational Ω-backgrounds are dual to CFT minimal models.

The static quark potential from the gauge independent Abelian decomposition

NASA Astrophysics Data System (ADS)

Cundy, Nigel; Cho, Y. M.; Lee, Weonjong; Leem, Jaehoon

2015-06-01

We investigate the relationship between colour confinement and the gauge independent Cho-Duan-Ge Abelian decomposition. The decomposition is defined in terms of a colour field n; the principle novelty of our study is that we have used a unique definition of this field in terms of the eigenvectors of the Wilson Loop. This allows us to establish an equivalence between the path-ordered integral of the non-Abelian gauge fields and an integral over an Abelian restricted gauge field which is tractable both theoretically and numerically in lattice QCD. We circumvent path ordering without requiring an additional path integral. By using Stokes' theorem, we can compute the Wilson Loop in terms of a surface integral over a restricted field strength, and show that the restricted field strength may be dominated by certain structures, which occur when one of the quantities parametrising the colour field n winds itself around a non-analyticity in the colour field. If they exist, these structures will lead to an area law scaling for the Wilson Loop and provide a mechanism for quark confinement. Unlike most studies of confinement using the Abelian decomposition, we do not rely on a dual-Meissner effect to create the inter-quark potential. We search for these structures in quenched lattice QCD. We perform the Abelian decomposition, and compare the electric and magnetic fields with the patterns expected theoretically. We find that the restricted field strength is dominated by objects which may be peaks of a single lattice spacing in size or extended string-like lines of electromagnetic flux. The objects are not isolated monopoles, as they generate electric fields in addition to magnetic fields, and the fields are not spherically symmetric, but may be either caused by a monopole/anti-monopole condensate, some other types of topological objects, or a combination of these. Removing these peaks removes the area law scaling of the string tension, suggesting that they are responsible for confinement.

Modeling the Monotonic and Cyclic Tensile Stress-Strain Behavior of 2D and 2.5D Woven C/SiC Ceramic-Matrix Composites

NASA Astrophysics Data System (ADS)

Li, L. B.

2018-05-01

The deformation of 2D and 2.5 C/SiC woven ceramic-matrix composites (CMCs) in monotonic and cyclic loadings has been investigated. Statistical matrix multicracking and fiber failure models and the fracture mechanics interface debonding approach are used to determine the spacing of matrix cracks, the debonded length of interface, and the fraction of broken fibers. The effects of fiber volume fraction and fiber Weibull modulus on the damage evolution in the composites and on their tensile stress-strain curves are analyzed. When matrix multicracking and fiber/matrix interface debonding occur, the fiber slippage relative to the matrix in the debonded interface region of the 0° warp yarns is the main reason for the emergance of stress-strain hysteresis loops for 2D and 2.5D woven CMCs. A model of these loops is developed, and histeresis loops for the composites in cyclic loadings/unloadings are predicted.

Calculation of K →π π decay amplitudes with improved Wilson fermion action in lattice QCD

NASA Astrophysics Data System (ADS)

Ishizuka, N.; Ishikawa, K.-I.; Ukawa, A.; Yoshié, T.

2015-10-01

We present our result for the K →π π decay amplitudes for both the Δ I =1 /2 and 3 /2 processes with the improved Wilson fermion action. Expanding on the earlier works by Bernard et al. and by Donini et al., we show that mixings with four-fermion operators with wrong chirality are absent even for the Wilson fermion action for the parity odd process in both channels due to CPS symmetry. Therefore, after subtraction of an effect from the lower dimensional operator, a calculation of the decay amplitudes is possible without complications from operators with wrong chirality, as for the case with chirally symmetric lattice actions. As a first step to verify the possibility of calculations with the Wilson fermion action, we consider the decay amplitudes at an unphysical quark mass mK˜2 mπ . Our calculations are carried out with Nf=2 +1 gauge configurations generated with the Iwasaki gauge action and nonperturbatively O (a )-improved Wilson fermion action at a =0.091 fm , mπ=280 MeV , and mK=580 MeV on a 323×64 (L a =2.9 fm ) lattice. For the quark loops in the penguin and disconnected contributions in the I =0 channel, the combined hopping parameter expansion and truncated solver method work very well for variance reduction. We obtain, for the first time with a Wilson-type fermion action, that Re A0=60 (36 )×1 0-8 GeV and Im A0=-67 (56 )×1 0-12 GeV for a matching scale q*=1 /a . The dependence on the matching scale q* for these values is weak.

Mixed heavy–light matching in the Universal One-Loop Effective Action

DOE PAGES

Ellis, Sebastian A. R.; Quevillon, Jérémie; You, Tevong; ...

2016-11-10

Recently, a general result for evaluating the path integral at one loop was obtained in the form of the Universal One-Loop Effective Action. It may be used to derive effective field theory operators of dimensions up to six, by evaluating the traces of matrices in this expression, with the mass dependence encapsulated in the universal coefficients. In this study we show that it can account for loops of mixed heavy–light particles in the matching procedure. Our prescription for computing these mixed contributions to the Wilson coefficients is conceptually simple. Moreover it has the advantage of maintaining the universal structure ofmore » the effective action, which we illustrate using the example of integrating out a heavy electroweak triplet scalar coupling to a light Higgs doublet. Finally we also identify new structures that were previously neglected in the universal results.« less

Draft Treatability Study in Support of Remediation by Natural Attenuation Building 1212 at Fairchild Air Force Base, Spokane, Washington

DTIC Science & Technology

1997-01-01

1975; Atlas , 1981, 1984, and 1988; Gibson and Subramanian, 1984; Reinhard et al., 1984; Young, 1984; Bartha , 1986; Wilson et al., 1986, 1987, and...Biotechnology of petroleum pollutant biodegradation: Microbial Ecology , vol. 12, p. 155-172. Bauman, B., 1991, Biodegradation research of the American...Perry, J.J., 1984, Microbial Metabolism of Cyclic Alkanes, In: Atlas , R.M ed. Petroleum Microbiology. Macmillan Publishing Co., New York, New York

Extending the Universal One-Loop Effective Action: heavy-light coefficients

DOE PAGES

Ellis, Sebastian A. R.; Quevillon, Jérémie; You, Tevong; ...

2017-08-16

The Universal One-Loop Effective Action (UOLEA) is a general expression for the effective action obtained by evaluating in a model-independent way the one-loop expansion of a functional path integral. It can also be used to match UV theories to their low-energy EFTs more efficiently by avoiding redundant steps in the application of functional methods, simplifying the process of obtaining Wilson coefficients of operators up to dimension six. In addition to loops involving only heavy fields, matching may require the inclusion of loops containing both heavy and light particles. Here we use the recently-developed covariant diagram technique to extend the UOLEAmore » to include heavy-light terms which retain the same universal structure as the previously-derived heavy-only terms. As an example of its application, we integrate out a heavy singlet scalar with a linear coupling to a light doublet Higgs. The extension presented here is a first step towards completing the UOLEA to incorporate all possible structures encountered in a covariant derivative expansion of the one-loop path integral.« less

Extending the Universal One-Loop Effective Action: heavy-light coefficients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, Sebastian A. R.; Quevillon, Jérémie; You, Tevong

The Universal One-Loop Effective Action (UOLEA) is a general expression for the effective action obtained by evaluating in a model-independent way the one-loop expansion of a functional path integral. It can also be used to match UV theories to their low-energy EFTs more efficiently by avoiding redundant steps in the application of functional methods, simplifying the process of obtaining Wilson coefficients of operators up to dimension six. In addition to loops involving only heavy fields, matching may require the inclusion of loops containing both heavy and light particles. Here we use the recently-developed covariant diagram technique to extend the UOLEAmore » to include heavy-light terms which retain the same universal structure as the previously-derived heavy-only terms. As an example of its application, we integrate out a heavy singlet scalar with a linear coupling to a light doublet Higgs. The extension presented here is a first step towards completing the UOLEA to incorporate all possible structures encountered in a covariant derivative expansion of the one-loop path integral.« less

The 3D Entangled Structure of the Proton: Transverse Degrees of Freedom in QCD, Momenta, Spins and More

NASA Astrophysics Data System (ADS)

Mulders, P. J.

2018-03-01

Light-front quantized quark and gluon states (partons) play a dominant role in high energy scattering processes. Initial state hadrons are mixed ensembles of partons, while produced pure partonic states appear as mixed ensembles of hadrons. The transition from collinear hard physics to the 3D structure including partonic transverse momenta is related to confinement which links color and spatial degrees of freedom. We outline ideas on emergent symmetries in the Standard Model and their connection to the 3D structure of hadrons. Wilson loops, including those with light-like Wilson lines such as used in the studies of transverse momentum dependent distribution functions may play a crucial role here, establishing a direct link between transverse spatial degrees of freedom and gluonic degrees of freedom.

Nonperturbative renormalization of the axial current in Nf=3 lattice QCD with Wilson fermions and a tree-level improved gauge action

NASA Astrophysics Data System (ADS)

Bulava, John; Della Morte, Michele; Heitger, Jochen; Wittemeier, Christian

2016-06-01

We nonperturbatively determine the renormalization factor of the axial vector current in lattice QCD with Nf=3 flavors of Wilson-clover fermions and the tree-level Symanzik-improved gauge action. The (by now standard) renormalization condition is derived from the massive axial Ward identity, and it is imposed among Schrödinger functional states with large overlap on the lowest lying hadronic state in the pseudoscalar channel, in order to reduce kinematically enhanced cutoff effects. We explore a range of couplings relevant for simulations at lattice spacings of ≈0.09 fm and below. An interpolation formula for ZA(g02) , smoothly connecting the nonperturbative values to the 1-loop expression, is provided together with our final results.

Modeling Cyclic Fatigue Hysteresis Loops of 2D Woven Ceramic Matrix Composites at Elevated Temperatures in Steam

PubMed Central

Li, Longbiao

2016-01-01

In this paper, the cyclic fatigue hysteresis loops of 2D woven SiC/SiC ceramic matrix composites (CMCs) at elevated temperatures in steam have been investigated. The interface slip between fibers and the matrix existing in matrix cracking modes 3 and 5, in which matrix cracking and interface debonding occurred in longitudinal yarns, is considered as the major reason for hysteresis loops of 2D woven CMCs. The hysteresis loops of 2D SiC/SiC composites corresponding to different peak stresses, test conditions, and loading frequencies have been predicted using the present analysis. The damage parameter, i.e., the proportion of matrix cracking mode 3 in the entire matrix cracking modes of the composite, and the hysteresis dissipated energy increase with increasing fatigue peak stress. With increasing cycle number, the interface shear stress in the longitudinal yarns decreases, leading to transition of interface slip types of matrix cracking modes 3 and 5. PMID:28773544

NLO evolution of color dipole

DOE PAGES

Balitsky, Ian; Chirilli, Giovanni A.

2008-09-01

The small-x deep inelastic scattering in the saturation region is governed by the non-linear evolution of Wilson-line operators. In the leading logarithmic approximation it is given by the BK equation for the evolution of color dipoles. In the next-to-leading order the BK equation gets contributions from quark and gluon loops as well as from the tree gluon diagrams with quadratic and cubic nonlinearities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rothstein, Ira Z.; Stewart, Iain W.

Starting with QCD, we derive an effective field theory description for forward scattering and factorization violation as part of the soft-collinear effective field theory (SCET) for high energy scattering. These phenomena are mediated by long distance Glauber gluon exchanges, which are static in time, localized in the longitudinal distance, and act as a kernel for forward scattering where |t| << s. In hard scattering, Glauber gluons can induce corrections which invalidate factorization. With SCET, Glauber exchange graphs can be calculated explicitly, and are distinct from graphs involving soft, collinear, or ultrasoft gluons. We derive a complete basis of operators whichmore » describe the leading power effects of Glauber exchange. Key ingredients include regulating light-cone rapidity singularities and subtractions which prevent double counting. Our results include a novel all orders gauge invariant pure glue soft operator which appears between two collinear rapidity sectors. The 1-gluon Feynman rule for the soft operator coincides with the Lipatov vertex, but it also contributes to emissions with ≥ 2 soft gluons. Our Glauber operator basis is derived using tree level and one-loop matching calculations from full QCD to both SCET II and SCET I. The one-loop amplitude’s rapidity renormalization involves mixing of color octet operators and yields gluon Reggeization at the amplitude level. The rapidity renormalization group equation for the leading soft and collinear functions in the forward scattering cross section are each given by the BFKL equation. Various properties of Glauber gluon exchange in the context of both forward scattering and hard scattering factorization are described. For example, we derive an explicit rule for when eikonalization is valid, and provide a direct connection to the picture of multiple Wilson lines crossing a shockwave. In hard scattering operators Glauber subtractions for soft and collinear loop diagrams ensure that we are not sensitive to the directions for soft and collinear Wilson lines. Conversely, certain Glauber interactions can be absorbed into these soft and collinear Wilson lines by taking them to be in specific directions. Finally, we also discuss criteria for factorization violation.« less

An effective field theory for forward scattering and factorization violation

DOE PAGES

Rothstein, Ira Z.; Stewart, Iain W.

2016-08-03

Starting with QCD, we derive an effective field theory description for forward scattering and factorization violation as part of the soft-collinear effective field theory (SCET) for high energy scattering. These phenomena are mediated by long distance Glauber gluon exchanges, which are static in time, localized in the longitudinal distance, and act as a kernel for forward scattering where |t| << s. In hard scattering, Glauber gluons can induce corrections which invalidate factorization. With SCET, Glauber exchange graphs can be calculated explicitly, and are distinct from graphs involving soft, collinear, or ultrasoft gluons. We derive a complete basis of operators whichmore » describe the leading power effects of Glauber exchange. Key ingredients include regulating light-cone rapidity singularities and subtractions which prevent double counting. Our results include a novel all orders gauge invariant pure glue soft operator which appears between two collinear rapidity sectors. The 1-gluon Feynman rule for the soft operator coincides with the Lipatov vertex, but it also contributes to emissions with ≥ 2 soft gluons. Our Glauber operator basis is derived using tree level and one-loop matching calculations from full QCD to both SCET II and SCET I. The one-loop amplitude’s rapidity renormalization involves mixing of color octet operators and yields gluon Reggeization at the amplitude level. The rapidity renormalization group equation for the leading soft and collinear functions in the forward scattering cross section are each given by the BFKL equation. Various properties of Glauber gluon exchange in the context of both forward scattering and hard scattering factorization are described. For example, we derive an explicit rule for when eikonalization is valid, and provide a direct connection to the picture of multiple Wilson lines crossing a shockwave. In hard scattering operators Glauber subtractions for soft and collinear loop diagrams ensure that we are not sensitive to the directions for soft and collinear Wilson lines. Conversely, certain Glauber interactions can be absorbed into these soft and collinear Wilson lines by taking them to be in specific directions. Finally, we also discuss criteria for factorization violation.« less

Closing the Loop: A Study of How the National Survey of Student Engagement (NSSE) Is Used for Decision-Making and Planning in Student Affairs

ERIC Educational Resources Information Center

McCaul, Jennifer Lee

2015-01-01

"Closing the loop" is a commonly used phrase in discussing cyclical processes, such as the area of outcomes assessment in higher education. Increased interest in accountability and a shift in accreditation focus have necessitated that higher education institutions are closing the assessment loop and creating a culture of evidence to…

Selectivity in ligand recognition of G-quadruplex loops.

PubMed

Campbell, Nancy H; Patel, Manisha; Tofa, Amina B; Ghosh, Ragina; Parkinson, Gary N; Neidle, Stephen

2009-03-03

A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, Sebastian A. R.; Quevillon, Jérémie; You, Tevong

Recently, a general result for evaluating the path integral at one loop was obtained in the form of the Universal One-Loop Effective Action. It may be used to derive effective field theory operators of dimensions up to six, by evaluating the traces of matrices in this expression, with the mass dependence encapsulated in the universal coefficients. In this study we show that it can account for loops of mixed heavy–light particles in the matching procedure. Our prescription for computing these mixed contributions to the Wilson coefficients is conceptually simple. Moreover it has the advantage of maintaining the universal structure ofmore » the effective action, which we illustrate using the example of integrating out a heavy electroweak triplet scalar coupling to a light Higgs doublet. Finally we also identify new structures that were previously neglected in the universal results.« less

WannierTools: An open-source software package for novel topological materials

NASA Astrophysics Data System (ADS)

Wu, QuanSheng; Zhang, ShengNan; Song, Hai-Feng; Troyer, Matthias; Soluyanov, Alexey A.

2018-03-01

We present an open-source software package WannierTools, a tool for investigation of novel topological materials. This code works in the tight-binding framework, which can be generated by another software package Wannier90 (Mostofi et al., 2008). It can help to classify the topological phase of a given material by calculating the Wilson loop, and can get the surface state spectrum, which is detected by angle resolved photoemission (ARPES) and in scanning tunneling microscopy (STM) experiments. It also identifies positions of Weyl/Dirac points and nodal line structures, calculates the Berry phase around a closed momentum loop and Berry curvature in a part of the Brillouin zone (BZ).

From webs to polylogarithms

NASA Astrophysics Data System (ADS)

Gardi, Einan

2014-04-01

We compute a class of diagrams contributing to the multi-leg soft anomalous dimension through three loops, by renormalizing a product of semi-infinite non-lightlike Wilson lines in dimensional regularization. Using non-Abelian exponentiation we directly compute contributions to the exponent in terms of webs. We develop a general strategy to compute webs with multiple gluon exchanges between Wilson lines in configuration space, and explore their analytic structure in terms of α ij , the exponential of the Minkowski cusp angle formed between the lines i and j. We show that beyond the obvious inversion symmetry α ij → 1 /α ij , at the level of the symbol the result also admits a crossing symmetry α ij → - α ij , relating spacelike and timelike kinematics, and hence argue that in this class of webs the symbol alphabet is restricted to α ij and . We carry out the calculation up to three gluons connecting four Wilson lines, finding that the contributions to the soft anomalous dimension are remarkably simple: they involve pure functions of uniform weight, which are written as a sum of products of polylogarithms, each depending on a single cusp angle. We conjecture that this type of factorization extends to all multiple-gluon-exchange contributions to the anomalous dimension.

New constraints on dark matter effective theories from standard model loops.

PubMed

Crivellin, Andreas; D'Eramo, Francesco; Procura, Massimiliano

2014-05-16

We consider an effective field theory for a gauge singlet Dirac dark matter particle interacting with the standard model fields via effective operators suppressed by the scale Λ ≳ 1 TeV. We perform a systematic analysis of the leading loop contributions to spin-independent Dirac dark matter-nucleon scattering using renormalization group evolution between Λ and the low-energy scale probed by direct detection experiments. We find that electroweak interactions induce operator mixings such that operators that are naively velocity suppressed and spin dependent can actually contribute to spin-independent scattering. This allows us to put novel constraints on Wilson coefficients that were so far poorly bounded by direct detection. Constraints from current searches are already significantly stronger than LHC bounds, and will improve in the near future. Interestingly, the loop contribution we find is isospin violating even if the underlying theory is isospin conserving.

String theory, gauge theory and quantum gravity. Proceedings. Trieste Spring School and Workshop on String Theory, Gauge Theory and Quantum Gravity, Trieste (Italy), 11 - 22 Apr 1994.

NASA Astrophysics Data System (ADS)

1995-04-01

The following topics were dealt with: string theory, gauge theory, quantum gravity, quantum geometry, black hole physics and information loss, second quantisation of the Wilson loop, 2D Yang-Mills theory, topological field theories, equivariant cohomology, superstring theory and fermion masses, supergravity, topological gravity, waves in string cosmology, superstring theories, 4D space-time.

Air Base Attacks and Defensive Counters: Historical Lessons and Future Challenges

DTIC Science & Technology

2015-01-01

I. Reid, Murray Scot Tanner, and Barry Wilson, A Question of Balance: Political Context and Military Aspects of the China–Taiwan Dispute, Santa...this case, Ramstein AB, Germany) placed fighter shelters on loops in woods . Although the shelters are clearly visible from directly overhead in...this image, placing them in woods would have made target acquisition and attack more difficult for Warsaw Pact fighters. That is because, in the 1970s

Homological Order in Three and Four dimensions: Wilson Algebra, Entanglement Entropy and Twist Defects

NASA Astrophysics Data System (ADS)

Roy, Abhishek; Chen, Xiao; Teo, Jeffrey

2013-03-01

We investigate homological orders in two, three and four dimensions by studying Zk toric code models on simplicial, cellular or in general differential complexes. The ground state degeneracy is obtained from Wilson loop and surface operators, and the homological intersection form. We compute these for a series of closed 3 and 4 dimensional manifolds and study the projective representations of mapping class groups (modular transformations). Braiding statistics between point and string excitations in (3+1)-dimensions or between dual string excitations in (4+1)-dimensions are topologically determined by the higher dimensional linking number, and can be understood by an effective topological field theory. An algorithm for calculating entanglemnent entropy of any bipartition of closed manifolds is presented, and its topological signature is completely characterized homologically. Extrinsic twist defects (or disclinations) are studied in 2,3 and 4 dimensions and are shown to carry exotic fusion and braiding properties. Simons Fellowship

Electromagnetic corrections to the hadronic vacuum polarization of the photon within QEDL and QEDM

NASA Astrophysics Data System (ADS)

Bussone, Andrea; Della Morte, Michele; Janowski, Tadeusz

2018-03-01

We compute the leading QED corrections to the hadronic vacuum polarization (HVP) of the photon, relevant for the determination of leptonic anomalous magnetic moments, al. We work in the electroquenched approximation and use dynamical QCD configurations generated by the CLS initiative with two degenerate flavors of nonperturbatively O(a)-improved Wilson fermions. We consider QEDL and QEDM to deal with the finite-volume zero modes. We compare results for the Wilson loops with exact analytical determinations. In addition we make sure that the volumes and photon masses used in QEDM are such that the correct dispersion relation is reproduced by the energy levels extracted from the charged pions two-point functions. Finally we compare results for pion masses and the HVP between QEDL and QEDM. For the vacuum polarization, corrections with respect to the pure QCD case, at fixed pion masses, turn out to be at the percent level.

Cyclic voltammetry of apple fruits: Memristors in vivo.

PubMed

Volkov, Alexander G; Nyasani, Eunice K; Tuckett, Clayton; Blockmon, Avery L; Reedus, Jada; Volkova, Maya I

2016-12-01

A memristor is a resistor with memory that exhibits a pinched hysteretic relationship in cyclic voltammetry. Recently, we have found memristors in the electrical circuitry of plants and seeds. There are no publications in literature about the possible existence of memristors and electrical differentiators in fruits. Here we found that the electrostimulation of Golden Delicious or Arkansas Black apple fruits by bipolar periodic waves induces hysteresis loops with pinched points in cyclic voltammograms at low frequencies between 0.1MHz and 1MHz. At high frequencies of 1kHz, the pinched hysteresis loop transforms to a non-pinched hysteresis loop instead of a single line I=V/R for ideal memristors because the amplitude of electrical current depends on capacitance of a fruit's tissue and electrodes, frequency and direction of scanning. Electrostimulation of electrical circuits in apple fruits by periodic voltage waves also induces electrotonic potential propagation due to cell-to-cell electrical coupling with electrical differentiators. A differentiator is an electrical circuit in which the output of the circuit is approximately directly proportional to the rate of change of the input. The information gained from electrostimulation can be used to elucidate and to observe electrochemical and electrophysiological properties of electrical circuits in fruits. Copyright © 2016 Elsevier B.V. All rights reserved.

AdS/CFT in Fractional Dimension and Higher-Spins at One Loop

NASA Astrophysics Data System (ADS)

Skvortsov, Evgeny; Tran, Tung

2017-08-01

Large-$N$, $\\epsilon$-expansion or the conformal bootstrap allow one to make sense of some of conformal field theories in non-integer dimension, which suggests that AdS/CFT may also extend to fractional dimensions. It was shown recently that the sphere free energy and the $a$-anomaly coefficient of the free scalar field can be reproduced as a one-loop effect in the dual higher-spin theory in a number of integer dimensions. We extend this result to all integer and also to fractional dimensions. Upon changing the boundary conditions in the higher-spin theory the sphere free energy of the large-$N$ Wilson-Fisher CFT can also be reproduced from the higher-spin side.

Asymptotic 3-loop heavy flavor corrections to the charged current structure functions FLW+-W-(x ,Q2) and F2W+-W-(x ,Q2)

NASA Astrophysics Data System (ADS)

Behring, A.; Blümlein, J.; Falcioni, G.; De Freitas, A.; von Manteuffel, A.; Schneider, C.

2016-12-01

We derive the massive Wilson coefficients for the heavy flavor contributions to the nonsinglet charged current deep-inelastic scattering structure functions FLW+(x ,Q2)-FLW-(x ,Q2) and F2W+(x ,Q2)-F2W-(x ,Q2) in the asymptotic region Q2≫m2 to 3-loop order in quantum chromodynamics at general values of the Mellin variable N and the momentum fraction x . Besides the heavy quark pair production, also the single heavy flavor excitation s →c contributes. Numerical results are presented for the charm quark contributions, and consequences on the unpolarized Bjorken sum rule and Adler sum rule are discussed.

Ward identity and basis tensor gauge theory at one loop

NASA Astrophysics Data System (ADS)

Chung, Daniel J. H.

2018-06-01

Basis tensor gauge theory (BTGT) is a reformulation of ordinary gauge theory that is an analog of the vierbein formulation of gravity and is related to the Wilson line formulation. To match ordinary gauge theories coupled to matter, the BTGT formalism requires a continuous symmetry that we call the BTGT symmetry in addition to the ordinary gauge symmetry. After classically interpreting the BTGT symmetry, we construct using the BTGT formalism the Ward identities associated with the BTGT symmetry and the ordinary gauge symmetry. For a way of testing the quantum stability and the consistency of the Ward identities with a known regularization method, we explicitly renormalize the scalar QED at one loop using dimensional regularization using the BTGT formalism.

On the ground state of Yang-Mills theory

NASA Astrophysics Data System (ADS)

Bakry, Ahmed S.; Leinweber, Derek B.; Williams, Anthony G.

2011-08-01

We investigate the overlap of the ground state meson potential with sets of mesonic-trial wave functions corresponding to different gluonic distributions. We probe the transverse structure of the flux tube through the creation of non-uniform smearing profiles for the string of glue connecting two color sources in Wilson loop operator. The non-uniformly UV-regulated flux-tube operators are found to optimize the overlap with the ground state and display interesting features in the ground state overlap.

Quantum Gravity in Cyclic (ekpyrotic) and Multiple (anthropic) Universes with Strings And/or Loops

NASA Astrophysics Data System (ADS)

Chung, T. J.

2008-09-01

This paper addresses a hypothetical extension of ekpyrotic and anthropic principles, implying cyclic and multiple universes, respectively. Under these hypotheses, from time immemorial (t = -∞), a universe undergoes a big bang from a singularity, initially expanding and eventually contracting to another singularity (big crunch). This is to prepare for the next big bang, repeating these cycles toward eternity (t = +∞), every 30 billion years apart. Infinity in time backward and forward (t = ±∞) is paralleled with infinity in space (Xi = ±∞), allowing multiple universes to prevail, each undergoing big bangs and big crunches similarly as our own universe. It is postulated that either string theory and /or loop quantum gravity might be able to substantiate these hypotheses.

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor*

PubMed Central

Daly, Norelle L.; Thorstholm, Louise; Greenwood, Kathryn P.; King, Gordon J.; Rosengren, K. Johan; Heras, Begoña; Martin, Jennifer L.; Craik, David J.

2013-01-01

MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity and, on the basis of its exceptional proteolytic stability, is a valuable template for the design of novel drug leads. Insights into inhibitor dynamics and interactions with biological targets are critical for drug design studies, particularly for protease targets. Here, we show that the cyclization and active site loops of MCoTI-II are flexible in solution, but when bound to trypsin, the active site loop converges to a single well defined conformation. This finding of reduced flexibility on binding is in contrast to a recent study on the homologous peptide MCoTI-I, which suggested that regions of the peptide are more flexible upon binding to trypsin. We provide a possible explanation for this discrepancy based on degradation of the complex over time. Our study also unexpectedly shows that the cyclization loop, not present in acyclic homologues, facilitates potent trypsin inhibitory activity by engaging in direct binding interactions with trypsin. PMID:24169696

Cyclic coordinate descent: A robotics algorithm for protein loop closure.

PubMed

Canutescu, Adrian A; Dunbrack, Roland L

2003-05-01

In protein structure prediction, it is often the case that a protein segment must be adjusted to connect two fixed segments. This occurs during loop structure prediction in homology modeling as well as in ab initio structure prediction. Several algorithms for this purpose are based on the inverse Jacobian of the distance constraints with respect to dihedral angle degrees of freedom. These algorithms are sometimes unstable and fail to converge. We present an algorithm developed originally for inverse kinematics applications in robotics. In robotics, an end effector in the form of a robot hand must reach for an object in space by altering adjustable joint angles and arm lengths. In loop prediction, dihedral angles must be adjusted to move the C-terminal residue of a segment to superimpose on a fixed anchor residue in the protein structure. The algorithm, referred to as cyclic coordinate descent or CCD, involves adjusting one dihedral angle at a time to minimize the sum of the squared distances between three backbone atoms of the moving C-terminal anchor and the corresponding atoms in the fixed C-terminal anchor. The result is an equation in one variable for the proposed change in each dihedral. The algorithm proceeds iteratively through all of the adjustable dihedral angles from the N-terminal to the C-terminal end of the loop. CCD is suitable as a component of loop prediction methods that generate large numbers of trial structures. It succeeds in closing loops in a large test set 99.79% of the time, and fails occasionally only for short, highly extended loops. It is very fast, closing loops of length 8 in 0.037 sec on average.

Increased intestinal absorption in the rat caused by sodium lauryl sulphate, and its possible relation to the cAMP system.

PubMed

Briseid, G; Briseid, K; Kirkevold, K

1976-01-01

The increases in the absorption of ouabain, phenolsulphonphthalein and pralidoxime caused by 17 mM sodium lauryl sulphate (SLS) from jejunal loops of anaesthetized rats were significantly reduced if sodium and chloride (Briseid et al., 1974) or chloride and bicarbonate were replaced by other ions in the loop fluid. Separate substitutions of sodium, chloride of bicarbonate did not significantly alter the SLS-caused absorption, except that the substitution of choline for sodium reduced the absorption of pralidoxime, both in the presence and in the absence of SLS. The increases in the absorption of phenolsulphonphthalein and pralidoxime caused by SLS were potentiated by theophylline (25 mM) and reduced by imidazole (25 mM). The addition of dibutyryl cyclic AMP (2.5 mM) to the loop fluid increased this absorption of the test substances. This effect was reduced by imidazole, but under the experimental conditions it was not potentiated by theophylline. Determinations of cyclic AMP in the rat intestinal mucosa showed that the level of this substance was significantly higher in the presence than in the absence of SLS. The experimental conditions were as described for the absorption experiments. It is concluded that the data obtained support the idea of an increased level of cyclic AMP as the main basis for the effect of SLS on the absorption.

Continuum strong-coupling expansion of Yang-Mills theory: quark confinement and infra-red slavery

NASA Astrophysics Data System (ADS)

Mansfield, Paul

1994-04-01

We solve Schrödinger's equation for the ground-state of four-dimensional Yang-Mills theory as an expansion in inverse powers of the coupling. Expectation values computed with the leading-order approximation are reduced to a calculation in two-dimensional Yang-Mills theory which is known to confine. Consequently the Wilson loop in the four-dimensional theory obeys an area law to leading order and the coupling becomes infinite as the mass scale goes to zero.

Experimental design for three-color and four-color gene expression microarrays.

PubMed

Woo, Yong; Krueger, Winfried; Kaur, Anupinder; Churchill, Gary

2005-06-01

Three-color microarrays, compared with two-color microarrays, can increase design efficiency and power to detect differential expression without additional samples and arrays. Furthermore, three-color microarray technology is currently available at a reasonable cost. Despite the potential advantages, clear guidelines for designing and analyzing three-color experiments do not exist. We propose a three- and a four-color cyclic design (loop) and a complementary graphical representation to help design experiments that are balanced, efficient and robust to hybridization failures. In theory, three-color loop designs are more efficient than two-color loop designs. Experiments using both two- and three-color platforms were performed in parallel and their outputs were analyzed using linear mixed model analysis in R/MAANOVA. These results demonstrate that three-color experiments using the same number of samples (and fewer arrays) will perform as efficiently as two-color experiments. The improved efficiency of the design is somewhat offset by a reduced dynamic range and increased variability in the three-color experimental system. This result suggests that, with minor technological improvements, three-color microarrays using loop designs could detect differential expression more efficiently than two-color loop designs. http://www.jax.org/staff/churchill/labsite/software Multicolor cyclic design construction methods and examples along with additional results of the experiment are provided at http://www.jax.org/staff/churchill/labsite/pubs/yong.

Effective field theory of integrating out sfermions in the MSSM: Complete one-loop analysis

NASA Astrophysics Data System (ADS)

Huo, Ran

2018-04-01

We apply the covariant derivative expansion of the Coleman-Weinberg potential to the sfermion sector in the minimal supersymmetric standard model, matching it to the relevant dimension-6 operators in the standard model effective field theory at one-loop level. Emphasis is paid to nondegenerate large soft supersymmetry breaking mass squares, and the most general analytical Wilson coefficients are obtained for all pure bosonic dimension-6 operators. In addition to the non-logarithmic contributions, they generally have another logarithmic contributions. Various numerical results are shown, in particular the constraints in the large Xt branch reproducing the 125 GeV Higgs mass can be pushed to high values to almost completely probe the low stop mass region at the future FCC-ee experiment, even given the Higgs mass calculation uncertainty.

One-loop calculations in Supersymmetric Lattice QCD

NASA Astrophysics Data System (ADS)

Costa, M.; Panagopoulos, H.

2017-03-01

We study the self energies of all particles which appear in a lattice regularization of supersymmetric QCD (N = 1). We compute, perturbatively to one-loop, the relevant two-point Green's functions using both the dimensional and the lattice regularizations. Our lattice formulation employs the Wilson fermion acrion for the gluino and quark fields. The gauge group that we consider is SU(Nc) while the number of colors, Nc and the number of flavors, Nf , are kept as generic parameters. We have also searched for relations among the propagators which are computed from our one-loop results. We have obtained analytic expressions for the renormalization functions of the quark field (Zψ), gluon field (Zu), gluino field (Zλ) and squark field (ZA±). We present here results from dimensional regularization, relegating to a forthcoming publication [1] our results along with a more complete list of references. Part of the lattice study regards also the renormalization of quark bilinear operators which, unlike the nonsupersymmetric case, exhibit a rich pattern of operator mixing at the quantum level.

Cyclic Axial-Torsional Deformation Behavior of a Cobalt-Base Superalloy

NASA Technical Reports Server (NTRS)

Bonacuse, Peter J.; Kalluri, Sreeramesh

1995-01-01

The cyclic, high-temperature deformation behavior of a wrought cobalt-base super-alloy, Haynes 188, is investigated under combined axial and torsional loads. This is accomplished through the examination of hysteresis loops generated from a biaxial fatigue test program. A high-temperature axial, torsional, and combined axial-torsional fatigue database has been generated on Haynes 188 at 760 C. Cyclic loading tests have been conducted on uniform gage section tubular specimens in a servohydraulic axial-torsional test rig. Test control and data acquisition were accomplished with a minicomputer. The fatigue behavior of Haynes 188 at 760 C under axial, torsional, and combined axial-torsional loads and the monotonic and cyclic deformation behaviors under axial and torsional loads have been previously reported. In this paper, the cyclic hardening characteristics and typical hysteresis loops in the axial stress versus axial strain, shear stress ,versus engineering shear strain, axial strain versus engineering shear strain. and axial stress versus shear stress spaces are presented for cyclic in-phase and out-of-phase axial-torsional tests. For in-phase tests, three different values of the proportionality constant lambda (the ratio of engineering shear strain amplitude to axial strain amplitude, are examined, viz. 0.86, 1.73, and 3.46. In the out-of-phase tests, three different values of the phase angle, phi (between the axial and engineering shear strain waveforms), are studied, viz., 30, 60, and 90 degrees with lambda equals 1.73. The cyclic hardening behaviors of all the tests conducted on Haynes 188 at 760 C are evaluated using the von Mises equivalent stress-strain and the maximum shear stress-maximum engineering shear strain (Tresca) curves. Comparisons are also made between the hardening behaviors of cyclic axial, torsional, and combined in-phase (lambda = 1.73 and phi = 0) and out-of-phase (lambda = 1.73 and phi = 90') axial-torsional fatigue tests. These comparisons are accomplished through simple Ramberg-Osgood type stress-strain functions for cyclic, axial stress-strain and shear stress-engineering shear strain curves.

Matrix models for 5d super Yang-Mills

NASA Astrophysics Data System (ADS)

Minahan, Joseph A.

2017-11-01

In this contribution to the issue on localization in gauge theories we investigate the matrix models derived from localizing N=1 super Yang-Mills on S 5. We consider the large-N limit and attempt to solve the matrix model by a saddle-point approximation. In general it is not possible to find an analytic solution, but at the weak and the strong limits of the ’t Hooft coupling there are dramatic simplifications that allows us to extract most of the interesting information. At weak coupling we show that the matrix model is close to the Gaussian matrix model and that the free-energy scales as N 2. At strong coupling we show that if the theory contains one adjoint hypermultiplet then the free-energy scales as N 3. We also find the expectation value of a supersymmetric Wilson loop that wraps the equator. We demonstrate how to extract the effective couplings and reproduce results of Seiberg. Finally, we compare to results for the six-dimensional (2,0) theory derived using the AdS/CFT correspondence. We show that by choosing the hypermultiplet mass such that the supersymmetry is enhanced to N=2 , the Wilson loop result matches the analogous calculation using AdS/CFT. The free-energies differ by a rational fraction. This is a contribution to the review issue ‘Localization techniques in quantum field theories’ (ed Pestun and Zabzine) which contains 17 chapters available at [1].

Quenching parameter in a holographic thermal QCD

NASA Astrophysics Data System (ADS)

Patra, Binoy Krishna; Arya, Bhaskar

2017-01-01

We have calculated the quenching parameter, q ˆ in a model-independent way using the gauge-gravity duality. In earlier calculations, the geometry in the gravity side at finite temperature was usually taken as the pure AdS black hole metric for which the dual gauge theory becomes conformally invariant unlike QCD. Therefore we use a metric which incorporates the fundamental quarks by embedding the coincident D7 branes in the Klebanov-Tseytlin background and a finite temperature is switched on by inserting a black hole into the background, known as OKS-BH metric. Further inclusion of an additional UV cap to the metric prepares the dual gauge theory to run similar to thermal QCD. Moreover q ˆ is usually defined in the literature from the Glauber model perturbative QCD evaluation of the Wilson loop, which has no reasons to hold if the coupling is large and is thus against the main idea of gauge-gravity duality. Thus we use an appropriate definition of q ˆ : q ˆ L- = 1 /L2, where L is the separation for which the Wilson loop is equal to some specific value. The above two refinements cause q ˆ to vary with the temperature as T4 always and to depend linearly on the light-cone time L- with an additional (1 /L-) correction term in the short-distance limit whereas in the long-distance limit, q ˆ depends only linearly on L- with no correction term. These observations agree with other holographic calculations directly or indirectly.

Analytic Result for the Two-loop Six-point NMHV Amplitude in N = 4 Super Yang-Mills Theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dixon, Lance J.; /SLAC; Drummond, James M.

2012-02-15

We provide a simple analytic formula for the two-loop six-point ratio function of planar N = 4 super Yang-Mills theory. This result extends the analytic knowledge of multi-loop six-point amplitudes beyond those with maximal helicity violation. We make a natural ansatz for the symbols of the relevant functions appearing in the two-loop amplitude, and impose various consistency conditions, including symmetry, the absence of spurious poles, the correct collinear behavior, and agreement with the operator product expansion for light-like (super) Wilson loops. This information reduces the ansatz to a small number of relatively simple functions. In order to fix these parametersmore » uniquely, we utilize an explicit representation of the amplitude in terms of loop integrals that can be evaluated analytically in various kinematic limits. The final compact analytic result is expressed in terms of classical polylogarithms, whose arguments are rational functions of the dual conformal cross-ratios, plus precisely two functions that are not of this type. One of the functions, the loop integral {Omega}{sup (2)}, also plays a key role in a new representation of the remainder function R{sub 6}{sup (2)} in the maximally helicity violating sector. Another interesting feature at two loops is the appearance of a new (parity odd) x (parity odd) sector of the amplitude, which is absent at one loop, and which is uniquely determined in a natural way in terms of the more familiar (parity even) x (parity even) part. The second non-polylogarithmic function, the loop integral {tilde {Omega}}{sup (2)}, characterizes this sector. Both {Omega}{sup (2)} and {tilde {Omega}}{sup (2)} can be expressed as one-dimensional integrals over classical polylogarithms with rational arguments.« less

Piezoelectric and dielectric performance of poled lead zirconate titanate subjected to electric cyclic fatigue

NASA Astrophysics Data System (ADS)

Wang, Hong; Matsunaga, Tadashi; Lin, Hua-Tay; Mottern, Alexander M.

2012-02-01

Poled lead zirconate titanate (PZT) material as a single-layer plate was tested using a piezodilatometer under electric cyclic loading in both unipolar and bipolar modes. Its responses were evaluated using unipolar and bipolar measurements on the same setup. The mechanical strain and charge density loops exhibited various variations when the material was cycled for more than 108 cycles. The various quantities including loop amplitude, hysteresis, switchable polarization, and coercive field were characterized accordingly under the corresponding measurement conditions. At the same time, the offset polarization and bias electric field of the material were observed to be changed and the trend was found to be related to the measurement conditions also. Finally, the piezoelectric and dielectric coefficients were analyzed and their implications for the application of interest have been discussed.

Complex heavy-quark potential at finite temperature from lattice QCD.

PubMed

Rothkopf, Alexander; Hatsuda, Tetsuo; Sasaki, Shoichi

2012-04-20

We calculate for the first time the complex potential between a heavy quark and antiquark at finite temperature across the deconfinement transition in lattice QCD. The real and imaginary part of the potential at each separation distance r is obtained from the spectral function of the thermal Wilson loop. We confirm the existence of an imaginary part above the critical temperature T(C), which grows as a function of r and underscores the importance of collisions with the gluonic environment for the melting of heavy quarkonia in the quark-gluon plasma.

Forecasting Low-Cycle Fatigue Performance of Twinning-Induced Plasticity Steels: Difficulty and Attempt

NASA Astrophysics Data System (ADS)

Shao, C. W.; Zhang, P.; Zhang, Z. J.; Liu, R.; Zhang, Z. F.

2017-12-01

We find the existing empirical relations based on monotonic tensile properties and/or hardness cannot satisfactorily predict the low-cycle fatigue (LCF) performance of materials, especially for twinning-induced plasticity (TWIP) steels. Given this, we first identified the different deformation mechanisms under monotonic and cyclic deformation after a comprehensive study of stress-strain behaviors and microstructure evolutions for Fe-Mn-C alloys during tension and LCF, respectively. It is found that the good tensile properties of TWIP steel mainly originate from the large activation of multiple twinning systems, which may be attributed to the grain rotation during tensile deformation; while its LCF performance depends more on the dislocation slip mode, in addition to its strength and plasticity. Based on this, we further investigate the essential relations between microscopic damage mechanism (dislocation-dislocation interaction) and cyclic stress response, and propose a hysteresis loop model based on dislocation annihilation theory, trying to quickly assess the LCF resistance of Fe-Mn-C steels as well as other engineering materials. It is suggested that the hysteresis loop and its evolution can provide significant information on cyclic deformation behavior, e.g., (point) defect multiplication and vacancy aggregation, which may help estimate the LCF properties.

A new momentum management controller for the space station

NASA Technical Reports Server (NTRS)

Wie, B.; Byun, K. W.; Warren, V. W.

1988-01-01

A new approach to CMG (control moment gyro) momentum management and attitude control of the Space Station is developed. The control algorithm utilizes both the gravity-gradient and gyroscopic torques to seek torque equilibrium attitude in the presence of secular and cyclic disturbances. Depending upon mission requirements, either pitch attitude or pitch-axis CMG momentum can be held constant: yaw attitude and roll-axis CMG momentum can be held constant, while roll attitude and yaw-axis CMG momentum cannot be held constant. As a result, the overall attitude and CMG momentum oscillations caused by cyclic aero-dynamic disturbances are minimized. A state feedback controller with minimal computer storage requirement for gain scheduling is also developed. The overall closed-loop system is stable for + or - 30 percent inertia matrix variations and has more than + or - 10 dB and 45 deg stability margins in each loop.

Initial conditions in high-energy collisions

NASA Astrophysics Data System (ADS)

Petreska, Elena

This thesis is focused on the initial stages of high-energy collisions in the saturation regime. We start by extending the McLerran-Venugopalan distribution of color sources in the initial wave-function of nuclei in heavy-ion collisions. We derive a fourth-order operator in the action and discuss its relevance for the description of color charge distributions in protons in high-energy experiments. We calculate the dipole scattering amplitude in proton-proton collisions with the quartic action and find an agreement with experimental data. We also obtain a modification to the fluctuation parameter of the negative binomial distribution of particle multiplicities in proton-proton experiments. The result implies an advancement of the fourth-order action towards Gaussian when the energy is increased. Finally, we calculate perturbatively the expectation value of the magnetic Wilson loop operator in the first moments of heavy-ion collisions. For the magnetic flux we obtain a first non-trivial term that is proportional to the square of the area of the loop. The result is close to numerical calculations for small area loops.

A Unified Approach for Modeling Inelastic Behavior of Structural Metals under Complex Cyclic Loadings.

DTIC Science & Technology

1977-05-01

this report are not to be used for advertising , publication, or promotional purposes. Citat ion of trade names does not constitute an off icial... Vs . Real Materials 3 PLASTIC HYSTERESIS PHENOMENA 12 Observed Transient Phenomena Analysis of Hysteresis Loops Observed Typical Yie ld Range...strain or stress amp litude). Fitr examp le , if varm m uus sited hyshet esis loops produced by the model a me super- Memory Modei Vs . Real Materials

Long-term cyclicities in Phanerozoic sea-level sedimentary record and their potential drivers

NASA Astrophysics Data System (ADS)

Boulila, Slah; Laskar, Jacques; Haq, Bilal U.; Galbrun, Bruno; Hara, Nathan

2018-06-01

Cyclic sedimentation has varied at several timescales and this variability has been geologically well documented at Milankovitch timescales, controlled in part by climatically (insolation) driven sea-level changes. At the longer (tens of Myr) timescales connection between astronomical parameters and sedimentation via cyclic solar-system motions within the Milky Way has also been proposed, but this hypothesis remains controversial because of the lack of long geological records. In addition, the absence of a meaningful physical mechanism that could explain the connection between climate and astronomy at these longer timescales led to the more plausible explanation of plate motions as the main driver of climate and sedimentation through changes in ocean and continent mass distribution on Earth. Here we statistically show a prominent and persistent 36 Myr sedimentary cyclicity superimposed on two megacycles ( 250 Myr) in a relatively well-constrained sea-level (SL) record of the past 542 Myr (Phanerozoic eon). We also show two other significant 9.3 and 91 Myr periodicities, but with lower amplitudes. The 9.3 Myr cyclicity was previously attributed to long-period Milankovitch band based on the Cenozoic record. However, the 91 Myr cyclicity has never been observed before in the geologic record. The 250 Myr cyclicity was attributed to the Wilson tectonic (supercontinent) cycle. The 36 Myr periodicity, also detected for the first time in SL record, has previously been ascribed either to tectonics or to astronomical cyclicity. Given the possible link between amplitudes of the 36 and 250 Myr cyclicities in SL record and the potential that these periodicities fall into the frequency band of solar system motions, we suggest an astronomical origin, and model these periodicities as originating from the path of the solar system in the Milky Way as vertical and radial periods that modulate the flux of cosmic rays on Earth. Our finding of the 36 Myr SL cyclicity lends credibility to the existing hypothesis about the imprint of solar-system vertical period on the geological record. The 250 Myr megacycles are tentatively attributed to a radial period. However, tectonic causal mechanisms remain equally plausible. The potential existence of a correlation between the modeled astronomical signal and the geological record may offer an indirect proxy to understand the structure and history of the Milky Way by providing a 542 Myr long record of the path of the Sun in our Galaxy.

Functional analysis of mutations in the ATP loop of the Wilson disease copper transporter, ATP7B.

PubMed

Luoma, Leiah M; Deeb, Taha M M; Macintyre, Georgina; Cox, Diane W

2010-05-01

Wilson disease (WND) is an autosomal recessive disorder resulting from mutation of ATP7B. Transport of copper by ATP7B from the trans-Golgi of hepatocytes into apical membrane-trafficked vesicles for excretion in the bile is the major means of copper elimination from the body. Although copper is an essential nutrient, homeostasis must be carefully maintained. If homeostasis is disrupted, copper can accumulate within the liver, kidney, cornea, and/or brain. The range of organs affected leads to clinical heterogeneity and difficulty in WND diagnosis. Sequencing of ATP7B is an important adjunct for diagnosis but has led to the discovery of many novel missense variants. Although prediction programs are available, functional characterization is essential for determining the consequence of novel variants. We have tested 12 missense variants localized to the ATP loop of ATP7B and compared three predictive programs (SIFT, PolyPhen, and Align-GVGD). We found p.L1043P, p.G1000R, p.G1101R, p.I1102T, p.V1239G, and p.D1267V deleterious; p.G1176E and p.G1287S intermediate; p.E1173G temperature sensitive; p.T991M and p.I1148T mild; and p.R1228T functioning as wild type. We found that SIFT most often agreed with functional data (92%), compared with PolyPhen (83%) and Align-GVGD (67%). We conclude that variants found to negatively affect function likely contribute to the WND phenotype in patients. (c) 2010 Wiley-Liss, Inc.

Biomechanical comparison of fixation methods in transverse patella fractures.

PubMed

Scilaris, T A; Grantham, J L; Prayson, M J; Marshall, M P; Hamilton, J J; Williams, J L

1998-01-01

To compare monofilament wire versus braided cable for stabilizing transverse patella fractures using the modified AO tension band technique. A randomized blocked (paired) study comparing two fixation methods. Statistical analysis was performed using a nested repeated measures analysis, followed by Bonferroni post hoc testing. Seven paired embalmed knees (mean age 71.8 years, SD 14.6 years) were dissected, and transverse fractures were simulated. The knees were reduced and randomly fixed by either two parallel 0.062-inch Kirschner wires with a 1.0-millimeter-diameter 316L stainless steel monofilament wire tension loop or two Kirschner wires with a 1.0-millimeter-diameter 316L stainless steel braided cable tension loop. Knees were tested by applying a cyclic load through the suprapatellar tendon between twenty and 300 newtons for thirty cycles. The maximum fracture displacement increased with each cycle of loading for both the braided cable and monofilament wire tension loop configurations (p = 0.0001). The average peak displacement at the thirtieth cycle was 2.25 millimeters for monofilament wire and 0.73 millimeters for the cable. When comparing both methods for all cycles, the braided cable allowed less fracture displacement than did the monofilament wire (p = 0.002), and the rate of increase per cycle of maximum fracture displacement was less for the cable than for the wire (p = 0.0001). In transverse, noncomminuted patella fractures, fixation with two Kirschner wires and a 1.0-millimeter braided cable tension loop was superior to the monofilament wire tension loop. Most importantly, the braided cable afforded more predictable results during cyclic loading.

Neural network controller development and implementation for spark ignition engines with high EGR levels.

PubMed

Vance, Jonathan Blake; Singh, Atmika; Kaul, Brian C; Jagannathan, Sarangapani; Drallmeier, James A

2007-07-01

Past research has shown substantial reductions in the oxides of nitrogen (NOx) concentrations by using 10%-25% exhaust gas recirculation (EGR) in spark ignition (SI) engines (see Dudek and Sain, 1989). However, under high EGR levels, the engine exhibits strong cyclic dispersion in heat release which may lead to instability and unsatisfactory performance preventing commercial engines to operate with high EGR levels. A neural network (NN)-based output feedback controller is developed to reduce cyclic variation in the heat release under high levels of EGR even when the engine dynamics are unknown by using fuel as the control input. A separate control loop was designed for controlling EGR levels. The stability analysis of the closed-loop system is given and the boundedness of the control input is demonstrated by relaxing separation principle, persistency of excitation condition, certainty equivalence principle, and linear in the unknown parameter assumptions. Online training is used for the adaptive NN and no offline training phase is needed. This online learning feature and model-free approach is used to demonstrate the applicability of the controller on a different engine with minimal effort. Simulation results demonstrate that the cyclic dispersion is reduced significantly using the proposed controller when implemented on an engine model that has been validated experimentally. For a single cylinder research engine fitted with a modern four-valve head (Ricardo engine), experimental results at 15% EGR indicate that cyclic dispersion was reduced 33% by the controller, an improvement of fuel efficiency by 2%, and a 90% drop in NOx from stoichiometric operation without EGR was observed. Moreover, unburned hydrocarbons (uHC) drop by 6% due to NN control as compared to the uncontrolled scenario due to the drop in cyclic dispersion. Similar performance was observed with the controller on a different engine.

Cyclic strain rate effects in fatigued face-centred and body-centred cubic metals

NASA Astrophysics Data System (ADS)

Mughrabi, Haël

2013-09-01

The present work deals mainly with the effect and the use of strain rate and temperature changes during cyclic deformation as a means to obtain valuable information on the thermally activated dislocation glide processes, based on the assessment of reversible changes of the thermal effective stress and of transient changes of the athermal stress. The importance of closed-loop testing in true plastic strain control with constant cyclic plastic strain rate throughout the cycle is explained and emphasized, especially with respect to the case of strain rate sensitive materials. Stress responses of face-centred cubic and body-centred cubic (bcc) metals to cyclic strain rate changes are presented to illustrate that the deformation modes of these two classes of materials differ characteristically at temperatures below that the so-called knee temperature of bcc metals. When such tests are performed in cyclic saturation, the temperature and strain rate dependence of bcc metals can be measured very accurately on one and the same specimen, permitting a thorough analysis of thermal activation.

Kaon B-parameter in mixed action chiral perturbation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aubin, C.; Laiho, Jack; Water, Ruth S. van de

2007-02-01

We calculate the kaon B-parameter, B{sub K}, in chiral perturbation theory for a partially quenched, mixed-action theory with Ginsparg-Wilson valence quarks and staggered sea quarks. We find that the resulting expression is similar to that in the continuum, and in fact has only two additional unknown parameters. At 1-loop order, taste-symmetry violations in the staggered sea sector only contribute to flavor-disconnected diagrams by generating an O(a{sup 2}) shift to the masses of taste-singlet sea-sea mesons. Lattice discretization errors also give rise to an analytic term which shifts the tree-level value of B{sub K} by an amount of O(a{sup 2}). Thismore » term, however, is not strictly due to taste breaking, and is therefore also present in the expression for B{sub K} for pure Ginsparg-Wilson lattice fermions. We also present a numerical study of the mixed B{sub K} expression in order to demonstrate that both discretization errors and finite volume effects are small and under control on the MILC improved staggered lattices.« less

Multiple feedback control apparatus for power conditioning equipment

NASA Technical Reports Server (NTRS)

Biess, John (Inventor); Yu, Yuan (Inventor)

1977-01-01

An improved feedback control system to govern the cyclic operation of the power switch of a non-dissipative power conditioning equipment. The apparatus includes two or three control loops working in unison. The first causes the output DC level to be compared with a reference, and the error amplified for control purposes. The second utilizes the AC component of the voltage across the output filter inductor or the current through the output filter capacitor, and the third loop senses the output transients.

Effect of Matrix Multicracking on the Hysteresis Loops of Carbon-Fiber-Reinforced Cross-Ply Ceramic-Matrix Composites

NASA Astrophysics Data System (ADS)

Li, L. B.

2017-01-01

The effect of matrix multicracking on the stress-strain hysteresis loops of cross-ply C/SiC ceramic-matrix composites (CMCs) under cyclic loading/unloading was investigated. When matrix multicracking and fiber/matrix interface debonding occur in the 0° plies, fiber slipping relative to the matrix in the debonded region of interface is the mainly reason for occurrence of the loops. The interfacial slip lengths, i.e., the debonded lengths of interface are determined, with consideration of matrix multicracking in the 90° and 0° plies, by using the fracture mechanics approach. The effects of peak stress, fiber volume content, fiber/matrix interfacial shear stress, and number of cycles on the hysteresis loops are analyzed. The stress-strain hysteresis loops of cross-ply C/SiC composites corresponding to different peak stresses and numbers of cycles are predicted.

Cyclic deformation and phase transformation of 6Mo superaustenitic stainless steel

NASA Astrophysics Data System (ADS)

Wang, Shing-Hoa; Wu, Chia-Chang; Chen, Chih-Yuan; Yang, Jer-Ren; Chiu, Po-Kay; Fang, Jason

2007-08-01

A fatigue behavior analysis was performed on superaustenitic stainless steel UNS S31254 (Avesta Sheffield 254 SMO), which contains about 6wt.% molybdenum, to examine the cyclic hardening/softening trend, hysteresis loops, the degree of hardening, and fatigue life during cyclic straining in the total strain amplitude range from 0.2 to 1.5%. Independent of strain rate, hardening occurs first, followed by softening. The degree of hardening is dependent on the magnitude of strain amplitude. The cyclic stress-strain curve shows material softening. The lower slope of the degree of hardening versus the strain amplitude curve at a high strain rate is attributed to the fast development of dislocation structures and quick saturation. The ɛ martensite formation, either in band or sheath form, depending on the strain rate, leads to secondary hardening at the high strain amplitude of 1.5%.

Application of an Uncoupled Elastic-plastic-creep Constitutive Model to Metals at High Temperature

NASA Technical Reports Server (NTRS)

Haisler, W. E.

1983-01-01

A uniaxial, uncoupled constitutive model to predict the response of thermal and rate dependent elastic-plastic material behavior is presented. The model is based on an incremental classicial plasticity theory extended to account for thermal, creep, and transient temperature conditions. Revisions to he combined hardening rule of the theory allow for better representation of cyclic phenomenon including the high rate of strain hardening upon cyclic reyield and cyclic saturation. An alternative approach is taken to model the rate dependent inelastic deformation which utilizes hysteresis loops and stress relaxation test data at various temperatures. The model is evaluated and compared to experiments which involve various thermal and mechanical load histories on 5086 aluminum alloy, 304 stainless steel and Hastelloy-X.

Hidden simplicity of gauge theory amplitudes

NASA Astrophysics Data System (ADS)

Drummond, J. M.

2010-11-01

These notes were given as lectures at the CERN Winter School on Supergravity, Strings and Gauge Theory 2010. We describe the structure of scattering amplitudes in gauge theories, focussing on the maximally supersymmetric theory to highlight the hidden symmetries which appear. Using the Britto, Cachzo, Feng and Witten (BCFW) recursion relations we solve the tree-level S-matrix in \\ {N}=4 super Yang-Mills theory and describe how it produces a sum of invariants of a large symmetry algebra. We review amplitudes in the planar theory beyond tree level, describing the connection between amplitudes and Wilson loops, and discuss the implications of the hidden symmetries.

Long distance quantum communication using quantum error correction

NASA Technical Reports Server (NTRS)

Gingrich, R. M.; Lee, H.; Dowling, J. P.

2004-01-01

We describe a quantum error correction scheme that can increase the effective absorption length of the communication channel. This device can play the role of a quantum transponder when placed in series, or a cyclic quantum memory when inserted in an optical loop.

The AdS/CFT Correspondence: Classical, Quantum, and Thermodynamical Aspects

NASA Astrophysics Data System (ADS)

Young, Donovan

2007-06-01

Certain aspects of the AdS/CFT correspondence are studied in detail. We investigate the one-loop mass shift to certain two-impurity string states in light-cone string field theory on a plane wave background. We find that there exist logarithmic divergences in the sums over intermediate mode numbers which cancel between the cubic Hamiltonian and quartic "contact term". We argue that generically, every order in intermediate state impurities contributes to the mass shift at leading perturbative order. The same mass shift is also computed using an improved 3-string vertex proposed by Dobashi and Yoneya. The result is found to agree with gauge theory at leading order and is close but not quite in agreement at subleading order. We extend the analysis to include discrete light-cone quantization, considering states with up to three units of p+. We study the (apparently) first-order phase transition in the weakly coupled plane-wave matrix model at finite temperature. We analyze the effect of interactions by computing the relevant parts of the effective potential for the Polyakov loop operator to three loop order. We show that the phase transition is indeed of first order. We also compute the 2-loop correction to the Hagedorn temperature. Finally, correlation functions of 1/4 BPS Wilson loops with the infinite family of 1/2 BPS chiral primary operators are computed in N=4 super Yang-Mills theory by summing planar ladder diagrams. The correlation functions are also computed in the strong-coupling limit using string theory; the result is found to agree with the extrapolation of the planar ladders. The result is related to similar correlators of 1/2 BPS loops by a simple re-scaling of the coupling constant, discovered by Drukker for the case of the 1/4 BPS loop VEV.

Cyclic axial-torsional deformation behavior of a cobalt-base superalloy

NASA Technical Reports Server (NTRS)

Bonacuse, Peter J.; Kalluri, Sreeramesh

1992-01-01

Multiaxial loading, especially at elevated temperature, can cause the inelastic response of a material to differ significantly from that predicted by simple flow rules, i.e., von Mises or Tresca. To quantify some of these differences, the cyclic high-temperature, deformation behavior of a wrought cobalt-based superalloy, Haynes 188, is investigated under combined axial and torsional loads. Haynes 188 is currently used in many aerospace gas turbine and rocket engine applications, e.g., the combustor liner for the T800 turboshaft engine for the RAH-66 Comanche helicopter and the liquid oxygen posts in the main injector of the space shuttle main engine. The deformation behavior of this material is assessed through the examination of hysteresis loops generated from a biaxial fatigue test program. A high-temperature axial, torsional, and combined axial-torsional fatigue data base has been generated on Haynes 188 at 760 C. Cyclic loading tests have been conducted on uniform gauge section tubular specimens in a servohydraulic axial-torsional test rig. Test control and data acquisition were accomplished with a minicomputer. In this paper, the cyclic hardening characteristics and typical hysteresis loops in the axial stress versus axial strain, shear stress versus engineering shear strain, axial strain versus engineering shear strain, and axial stress versus shear stress spaces are presented for cyclic, in-phase and out-of-phase, axial torsional tests. For in-phase tests three different values of the proportionality constant, lambda (ratio of engineering shear strain amplitude to axial strain amplitude), are examined, viz., 0.86, 1.73, and 3.46. In the out-of-phase tests, three different values of the phase angle, phi (between the axial and engineering shear strain waveforms), are studied, viz., 30, 60, and 90 deg with lambda = 1.73. The cyclic hardening behaviors of all the tests conducted on Haynes 188 at 760 C are evaluated using the von Mises equivalent stress-strain and the maximum shear stress-maximum engineering shear strain (Tresca) curves. Comparisons are also made between the hardening behaviors of cyclic axial, torsional, and combined in-phase and out-of-phase axial-torsional fatigue tests. These comparisons are accomplished through simple Ramberg-Osgood type stress-strain functions for cyclic, axial stress-strain and shear stress-engineering shear strain curves.

Isothermal Oxidation of Magnetite to Hematite in Air and Cyclic Reduction/Oxidation Under Carbon Looping Combustion Conditions

NASA Astrophysics Data System (ADS)

Simmonds, Tegan; Hayes, Peter C.

2017-12-01

In the carbon looping combustion process the oxygen carrier is regenerated through oxidation in air; this process has been simulated by the oxidation of dense synthetic magnetite for selected temperatures and times. The oxidation of magnetite in air is shown to occur through the formation of dense hematite layers on the particle surface. This dense hematite forms through lath type shear transformations or solid-state diffusion through the product layer. Cyclic reduction in CO-CO2/oxidation in air of hematite single crystals has been carried out under controlled laboratory conditions at 1173 K (900 °C). It has been shown that the initial reduction step is critical to determining the product microstructure, which consists of gas pore dendrites in the magnetite matrix with blocky hematite formed on the pore surfaces. The progressive growth of the magnetite layer with the application of subsequent cycles appears to continue until no original hematite remains, after which physical disintegration of the particles takes place.

Dualities and Topological Field Theories from Twisted Geometries

NASA Astrophysics Data System (ADS)

Markov, Ruza

I will present three studies of string theory on twisted geometries. In the first calculation included in this dissertation we use gauge/gravity duality to study the Coulomb branch of an unusual type of nonlocal field theory, called Puff Field Theory. On the gravity side, this theory is given in terms of D3-branes in type IIB string theory with a geometric twist. While the field theory description, available in the IR limit, is a deformation of Yang-Mills gauge theory by an order seven operator which we here compute. In the rest of this dissertation we explore N = 4 super Yang-Mills (SYM) theory compactied on a circle with S-duality and R-symmetry twists that preserve N = 6 supersymmetry in 2 + 1D. It was shown that abelian theory on a flat manifold gives Chern-Simons theory in the low-energy limit and here we are interested in the non-abelian counterpart. To that end, we introduce external static supersymmetric quark and anti-quark sources into the theory and calculate the Witten Index of the resulting Hilbert space of ground states on a two-torus. Using these results we compute the action of simple Wilson loops on the Hilbert space of ground states without sources. In some cases we find disagreement between our results for the Wilson loop eigenvalues and previous conjectures about a connection with Chern-Simons theory. The last result discussed in this dissertation demonstrates a connection between gravitational Chern-Simons theory and N = 4 four-dimensional SYM theory compactified on a circle twisted by S-duality where the remaining three-manifold is not flat starting with the explicit geometric realization of S-duality in terms of (2, 0) theory.

Mechanical behavior of NiTi arc wires under pseudoelastic cycling and cathodically hydrogen charging

NASA Astrophysics Data System (ADS)

Sarraj, R.; Hassine, T.; Gamaoun, F.

2018-01-01

NiTi wires are mainly used to design orthodontic devices. However, they may be susceptible to a delayed fracture while they are submitted to cyclic loading with the presence of hydrogen in the oral cavity. Hydrogen may cause the embrittlement of the structure, leading to lower ductility and to a change in transformation behavior. The aim of the present study is to predict the NiTi behavior under cyclic loading with hydrogen charging. One the one hand, samples are submitted to superelastic cyclic loading, which results in investigating their performance degradations. On the other hand, after hydrogen charging, cyclic tensile aging tests are carried out on NiTi orthodontic wires at room temperature in the air. During cyclic loading, we notice that the critical stress for the martensite transformation evolves, the residual strain is accumulated in the structure and the hysteresis loop changes. Thus, via this work, we can assume that the embrittlement is due to the diffusion of hydrogen and the generation of dislocations after aging. The evolution of mechanical properties of specimens becomes more significant with hydrogen charging rather than without it.

Enhancing the Electrochemical Behavior of Pure Copper by Cyclic Potentiodynamic Passivation: A Comparison between Coarse- and Nano-Grained Pure Copper

NASA Astrophysics Data System (ADS)

Fattah-alhosseini, Arash; Imantalab, Omid; Attarzadeh, Farid Reza

2016-10-01

Electrochemical behavior of coarse- and nano-grained pure copper were modified and improved to a large extent by the application of cyclic potentiodynamic passivation. The efficacy of this method was evaluated on the basis of grain size which is of great importance in corrosion studies. In this study, the eight passes of accumulative roll bonding process at room temperature were successfully performed to produce nano-grained pure copper. Transmission electron microscopy image indicated that the average grain size reached below 100 nm after eight passes. On the basis of cyclic voltammetry and also the electrochemical tests performed after that, it was revealed that cyclic potentiodynamic passivation had a significant improving effect on the passive behavior of both coarse- and nano-grained samples. In addition, a superior behavior of nano-grained sample in comparison to coarse-grained one was distinguished by its smaller cyclic voltammogram loops, nobler free potentials, larger capacitive arcs in the Nyquist plots, and less charge carrier densities within the passive film.

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

PubMed

Michalakis, Stylianos; Becirovic, Elvir; Biel, Martin

2018-03-07

The first step in vision is the absorption of photons by the photopigments in cone and rod photoreceptors. After initial amplification within the phototransduction cascade the signal is translated into an electrical signal by the action of cyclic nucleotide-gated (CNG) channels. CNG channels are ligand-gated ion channels that are activated by the binding of cyclic guanosine monophosphate (cGMP) or cyclic adenosine monophosphate (cAMP). Retinal CNG channels transduce changes in intracellular concentrations of cGMP into changes of the membrane potential and the Ca 2+ concentration. Structurally, the CNG channels belong to the superfamily of pore-loop cation channels and share a common gross structure with hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and voltage-gated potassium channels (KCN). In this review, we provide an overview on the molecular properties of CNG channels and describe their physiological role in the phototransduction pathways. We also discuss insights into the pathophysiological role of CNG channel proteins that have emerged from the analysis of CNG channel-deficient animal models and human CNG channelopathies. Finally, we summarize recent gene therapy activities and provide an outlook for future clinical application.

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy

PubMed Central

Biel, Martin

2018-01-01

The first step in vision is the absorption of photons by the photopigments in cone and rod photoreceptors. After initial amplification within the phototransduction cascade the signal is translated into an electrical signal by the action of cyclic nucleotide-gated (CNG) channels. CNG channels are ligand-gated ion channels that are activated by the binding of cyclic guanosine monophosphate (cGMP) or cyclic adenosine monophosphate (cAMP). Retinal CNG channels transduce changes in intracellular concentrations of cGMP into changes of the membrane potential and the Ca2+ concentration. Structurally, the CNG channels belong to the superfamily of pore-loop cation channels and share a common gross structure with hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and voltage-gated potassium channels (KCN). In this review, we provide an overview on the molecular properties of CNG channels and describe their physiological role in the phototransduction pathways. We also discuss insights into the pathophysiological role of CNG channel proteins that have emerged from the analysis of CNG channel-deficient animal models and human CNG channelopathies. Finally, we summarize recent gene therapy activities and provide an outlook for future clinical application. PMID:29518895

Calculating massive 3-loop graphs for operator matrix elements by the method of hyperlogarithms

NASA Astrophysics Data System (ADS)

Ablinger, Jakob; Blümlein, Johannes; Raab, Clemens; Schneider, Carsten; Wißbrock, Fabian

2014-08-01

We calculate convergent 3-loop Feynman diagrams containing a single massive loop equipped with twist τ=2 local operator insertions corresponding to spin N. They contribute to the massive operator matrix elements in QCD describing the massive Wilson coefficients for deep-inelastic scattering at large virtualities. Diagrams of this kind can be computed using an extended version of the method of hyperlogarithms, originally being designed for massless Feynman diagrams without operators. The method is applied to Benz- and V-type graphs, belonging to the genuine 3-loop topologies. In case of the V-type graphs with five massive propagators, new types of nested sums and iterated integrals emerge. The sums are given in terms of finite binomially and inverse binomially weighted generalized cyclotomic sums, while the 1-dimensionally iterated integrals are based on a set of ∼30 square-root valued letters. We also derive the asymptotic representations of the nested sums and present the solution for N∈C. Integrals with a power-like divergence in N-space ∝aN,a∈R,a>1, for large values of N emerge. They still possess a representation in x-space, which is given in terms of root-valued iterated integrals in the present case. The method of hyperlogarithms is also used to calculate higher moments for crossed box graphs with different operator insertions.

Cyclic variation of ultrasonic backscattering from porcine whole blood under pulsatile flow

NASA Astrophysics Data System (ADS)

Lin, Yu-Hong

1997-10-01

The cyclic variation of ultrasonic backscattering from blood under pulsatile flow is believed to be related to the change of aggregation state of red cells and is only observed in whole blood. This study was to investigate the phenomenon by an invasive approach which was performed by inserting a 10 MHz catheter mounted transducer into a vessel. For ultrasonic measurement from blood, the most fundamental scheme is the hematocrit dependence. The backscatter maximum location was changed as the blood was stirred or stationary, as well as under steady laminar or turbulent flows. The same trend was also observed under pulsatile flow with 10% to 50% hematocrits in this study, as the backscattering to hematocrit curves were plotted at different times during a flow cycle. When the cyclic variation at 20 beats per minute (BPM) was interpreted in time domain, the enhanced aggregation at the beginning of shearing was observed. At 20 BPM with 40% hematocrit, the amplitude of cyclic variation was reduced when the shear rate was increased and the threshold of 150 s-1 was estimated. The results showed that there was no cyclic variation at 60 BPM. The backscattering was also plotted against the mean flow velocity, which demonstrated the hysteresis loops. The ultrasonic measurements showed that the relationship between the forward and backward paths of the loops were altered as beat rate, hematocrit, and shear rate were varied. Since the pulsatile flow was very complicated, a computational fluid dynamics package, FIDAPTM, was used to compute the shear rate based on the Power Law Model for non-Newtonian fluid viscosity. The non- Newtonian index and consistency in the model were computed from the viscosity to shear rate curves at 10% to 50% hematocrits measured by a cone-plate viscometer. For in vivo measurements, small pigs were used as models. Ultrasonic backscattering measurements were performed in the arteries and veins. The effect of stenosis was also investigated at the site below the renal branch in the artery. The results show that the cyclic variation from whole blood was mediated by the shear rate, hematocrit, beat rate, and fibrinogen concentration.

Long Term Memory for Noise: Evidence of Robust Encoding of Very Short Temporal Acoustic Patterns.

PubMed

Viswanathan, Jayalakshmi; Rémy, Florence; Bacon-Macé, Nadège; Thorpe, Simon J

2016-01-01

Recent research has demonstrated that humans are able to implicitly encode and retain repeating patterns in meaningless auditory noise. Our study aimed at testing the robustness of long-term implicit recognition memory for these learned patterns. Participants performed a cyclic/non-cyclic discrimination task, during which they were presented with either 1-s cyclic noises (CNs) (the two halves of the noise were identical) or 1-s plain random noises (Ns). Among CNs and Ns presented once, target CNs were implicitly presented multiple times within a block, and implicit recognition of these target CNs was tested 4 weeks later using a similar cyclic/non-cyclic discrimination task. Furthermore, robustness of implicit recognition memory was tested by presenting participants with looped (shifting the origin) and scrambled (chopping sounds into 10- and 20-ms bits before shuffling) versions of the target CNs. We found that participants had robust implicit recognition memory for learned noise patterns after 4 weeks, right from the first presentation. Additionally, this memory was remarkably resistant to acoustic transformations, such as looping and scrambling of the sounds. Finally, implicit recognition of sounds was dependent on participant's discrimination performance during learning. Our findings suggest that meaningless temporal features as short as 10 ms can be implicitly stored in long-term auditory memory. Moreover, successful encoding and storage of such fine features may vary between participants, possibly depending on individual attention and auditory discrimination abilities. Significance Statement Meaningless auditory patterns could be implicitly encoded and stored in long-term memory.Acoustic transformations of learned meaningless patterns could be implicitly recognized after 4 weeks.Implicit long-term memories can be formed for meaningless auditory features as short as 10 ms.Successful encoding and long-term implicit recognition of meaningless patterns may strongly depend on individual attention and auditory discrimination abilities.

Long Term Memory for Noise: Evidence of Robust Encoding of Very Short Temporal Acoustic Patterns

PubMed Central

Viswanathan, Jayalakshmi; Rémy, Florence; Bacon-Macé, Nadège; Thorpe, Simon J.

2016-01-01

Recent research has demonstrated that humans are able to implicitly encode and retain repeating patterns in meaningless auditory noise. Our study aimed at testing the robustness of long-term implicit recognition memory for these learned patterns. Participants performed a cyclic/non-cyclic discrimination task, during which they were presented with either 1-s cyclic noises (CNs) (the two halves of the noise were identical) or 1-s plain random noises (Ns). Among CNs and Ns presented once, target CNs were implicitly presented multiple times within a block, and implicit recognition of these target CNs was tested 4 weeks later using a similar cyclic/non-cyclic discrimination task. Furthermore, robustness of implicit recognition memory was tested by presenting participants with looped (shifting the origin) and scrambled (chopping sounds into 10− and 20-ms bits before shuffling) versions of the target CNs. We found that participants had robust implicit recognition memory for learned noise patterns after 4 weeks, right from the first presentation. Additionally, this memory was remarkably resistant to acoustic transformations, such as looping and scrambling of the sounds. Finally, implicit recognition of sounds was dependent on participant's discrimination performance during learning. Our findings suggest that meaningless temporal features as short as 10 ms can be implicitly stored in long-term auditory memory. Moreover, successful encoding and storage of such fine features may vary between participants, possibly depending on individual attention and auditory discrimination abilities. Significance Statement Meaningless auditory patterns could be implicitly encoded and stored in long-term memory.Acoustic transformations of learned meaningless patterns could be implicitly recognized after 4 weeks.Implicit long-term memories can be formed for meaningless auditory features as short as 10 ms.Successful encoding and long-term implicit recognition of meaningless patterns may strongly depend on individual attention and auditory discrimination abilities. PMID:27932941

The anisotropic Wilson gauge action

NASA Astrophysics Data System (ADS)

Klassen, Timothy R.

1998-11-01

Anisotropic lattices, with a temporal lattice spacing smaller than the spatial one, allow precision Monte Carlo calculations of problems that are difficult to study otherwise: heavy quarks, glueballs, hybrids, and high temperature thermodynamics, for example. We here perform the first step required for such studies with the (quenched) Wilson gauge action, namely, the determination of the renormalized anisotropy Ξ as a function of the bare anisotropy Ξ0 and the coupling. By, essentially, comparing the finite-volume heavy quark potential where the quarks are separated along a spatial direction with that where they are separated along the time direction, we determine the relation between Ξ and Ξ0 to a fraction of 1% for weak and to 1% for strong coupling. We present a simple parameterization of this relation for 1 ⩽ Ξ ⩽ 6 and 5.5 ⩽ β ⩽ ∞, which incorporates the known one-loop result and reproduces our non-perturbative determinations within errors. Besides solving the problem of how to choose the bare anisotropies if one wants to take the continuum limit at fixed renormalized anisotropy, this parameterization also yields accurate estimates of the derivative {∂Ξ 0}/{∂Ξ} needed in thermodynamic studies.

Advanced compilation techniques in the PARADIGM compiler for distributed-memory multicomputers

NASA Technical Reports Server (NTRS)

Su, Ernesto; Lain, Antonio; Ramaswamy, Shankar; Palermo, Daniel J.; Hodges, Eugene W., IV; Banerjee, Prithviraj

1995-01-01

The PARADIGM compiler project provides an automated means to parallelize programs, written in a serial programming model, for efficient execution on distributed-memory multicomputers. .A previous implementation of the compiler based on the PTD representation allowed symbolic array sizes, affine loop bounds and array subscripts, and variable number of processors, provided that arrays were single or multi-dimensionally block distributed. The techniques presented here extend the compiler to also accept multidimensional cyclic and block-cyclic distributions within a uniform symbolic framework. These extensions demand more sophisticated symbolic manipulation capabilities. A novel aspect of our approach is to meet this demand by interfacing PARADIGM with a powerful off-the-shelf symbolic package, Mathematica. This paper describes some of the Mathematica routines that performs various transformations, shows how they are invoked and used by the compiler to overcome the new challenges, and presents experimental results for code involving cyclic and block-cyclic arrays as evidence of the feasibility of the approach.

Cyclic Hardness Test PHYBALCHT: A New Short-Time Procedure to Estimate Fatigue Properties of Metallic Materials

NASA Astrophysics Data System (ADS)

Kramer, Hendrik; Klein, Marcus; Eifler, Dietmar

Conventional methods to characterize the fatigue behavior of metallic materials are very time and cost consuming. That is why the new short-time procedure PHYBALCHT was developed at the Institute of Materials Science and Engineering at the University of Kaiserslautern. This innovative method requires only a planar material surface to perform cyclic force-controlled hardness indentation tests. To characterize the cyclic elastic-plastic behavior of the test material the change of the force-indentation-depth-hysteresis is plotted versus the number of indentation cycles. In accordance to the plastic strain amplitude the indentation-depth width of the hysteresis loop is measured at half minimum force and is called plastic indentation-depth amplitude. Its change as a function of the number of cycles of indentation can be described by power-laws. One of these power-laws contains the hardening-exponentCHT e II , which correlates very well with the amount of cyclic hardening in conventional constant amplitude fatigue tests.

Precision holography for N={2}^{\\ast } on S 4 from type IIB supergravity

NASA Astrophysics Data System (ADS)

Bobev, Nikolay; Gautason, Friðrik Freyr; van Muiden, Jesse

2018-04-01

We find a new supersymmetric solution of type IIB supergravity which is holographically dual to the planar limit of the four-dimensional N={2}^{\\ast } supersymmetric Yang-Mills theory on S 4. We study a probe fundamental string in this background which is dual to a supersymmetric Wilson loop in the N={2}^{\\ast } theory. Using holography we calculate the expectation value of this line operator to leading order in the 't Hooft coupling. The result is a non-trivial function of the mass parameter of the N={2}^{\\ast } theory that precisely matches the result from supersymmetric localization.

FAST TRACK COMMUNICATION: Regularized Kerr-Newman solution as a gravitating soliton

NASA Astrophysics Data System (ADS)

Burinskii, Alexander

2010-10-01

The charged, spinning and gravitating soliton is realized as a regular solution of the Kerr-Newman (KN) field coupled with a chiral Higgs model. A regular core of the solution is formed by a domain wall bubble interpolating between the external KN solution and a flat superconducting interior. An internal electromagnetic (em) field is expelled to the boundary of the bubble by the Higgs field. The solution reveals two new peculiarities: (i) the Higgs field is oscillating, similar to the known oscillon models; (ii) the em field forms on the edge of the bubble a Wilson loop, resulting in quantization of the total angular momentum.

STS-105 coverage of Mission Control Center employees in the WFCR & BFCR

NASA Image and Video Library

2003-03-25

JSC2001-E-25131 (16 August 2001) --- ISS flight director Mark Ferring (seated), assembly checkout officer (ACO) Jim Ruhnke and astronaut Stephanie D. Wilson, ISS spacecraft communicator (CAPCOM), discuss the progress of the extravehicular activities at their consoles in the station flight control room (BFCR) in Houston’s Mission Control Center (MCC). Operations support officer (OSO) Ted Kenny is in the background participating in the discussion over the voice loops. At the time this photo was taken, mission specialists Daniel T. Barry and Patrick G. Forrester were performing the first of two scheduled space walks during Discovery’s voyage to the International Space Station (ISS).

Renormalization group equations and the Lifshitz point in noncommutative Landau-Ginsburg theory

NASA Astrophysics Data System (ADS)

Chen, Guang-Hong; Wu, Yong-Shi

2002-02-01

A one-loop renormalization group (RG) analysis is performed for noncommutative Landau-Ginsburg theory in an arbitrary dimension. We adopt a modern version of the Wilsonian RG approach, in which a shell integration in momentum space bypasses the potential IR singularities due to UV-IR mixing. The momentum-dependent trigonometric factors in interaction vertices, characteristic of noncommutative geometry, are marginal under RG transformations, and their marginality is preserved at one loop. A negative Θ-dependent anomalous dimension is discovered as a novel effect of the UV-IR mixing. We also found a noncommutative Wilson-Fisher (NCWF) fixed point in less than four dimensions. At large noncommutativity, a momentum space instability is induced by quantum fluctuations, and a consequential first-order phase transition is identified together with a Lifshitz point in the phase diagram. In the vicinity of the Lifshitz point, we introduce two critical exponents νm and βk, whose values are determined to be 1/4 and 1/2, respectively, at mean-field level.

Perturbative tests for a large-N reduced model of {N} = {4} super Yang-Mills theory

NASA Astrophysics Data System (ADS)

Ishiki, Goro; Shimasaki, Shinji; Tsuchiya, Asato

2011-11-01

We study a non-perturbative formulation of {N} = {4} super Yang-Mills theory (SYM) on R × S 3 in the planar limit proposed in arXiv:0807.2352. This formulation is based on the large- N reduction, and the theory can be described as a particular large- N limit of the plane wave matrix model (PWMM), which is obtained by dimensionally reducing the original theory over S 3. In this paper, we perform some tests for this proposal. We construct an operator in the PWMM that corresponds to the Wilson loop in SYM in the continuum limit and calculate the vacuum expectation value of the operator for the case of the circular contour. We find that our result indeed agrees with the well-known result first obtained by Erickson, Semenoff and Zarembo. We also compute the beta function at the 1-loop level based on this formulation and see that it is indeed vanishing.

Perturbative tests for a large-N reduced model of mathcal{N} = {4} super Yang-Mills theory

NASA Astrophysics Data System (ADS)

Ishiki, Goro; Shimasaki, Shinji; Tsuchiya, Asato

2012-02-01

We study a non-perturbative formulation of mathcal{N} = {4} super Yang-Mills theory (SYM) on R × S 3 in the planar limit proposed in arXiv:0807.2352. This formulation is based on the large- N reduction, and the theory can be described as a particular large- N limit of the plane wave matrix model (PWMM), which is obtained by dimensionally reducing the original theory over S 3. In this paper, we perform some tests for this proposal. We construct an operator in the PWMM that corresponds to the Wilson loop in SYM in the continuum limit and calculate the vacuum expectation value of the operator for the case of the circular contour. We find that our result indeed agrees with the well-known result first obtained by Erickson, Semenoff and Zarembo. We also compute the beta function at the 1-loop level based on this formulation and see that it is indeed vanishing.

Quantum Wronskian approach to six-point gluon scattering amplitudes at strong coupling

NASA Astrophysics Data System (ADS)

Hatsuda, Yasuyuki; Ito, Katsushi; Satoh, Yuji; Suzuki, Junji

2014-08-01

We study the six-point gluon scattering amplitudes in = 4 super Yang-Mills theory at strong coupling based on the twisted ℤ4-symmetric integrable model. The lattice regularization allows us to derive the associated thermodynamic Bethe ansatz (TBA) equations as well as the functional relations among the Q-/T-/Y-functions. The quantum Wronskian relation for the Q-/T-functions plays an important role in determining a series of the expansion coefficients of the T-/Y-functions around the UV limit, including the dependence on the twist parameter. Studying the CFT limit of the TBA equations, we derive the leading analytic expansion of the remainder function for the general kinematics around the limit where the dual Wilson loops become regular-polygonal. We also compare the rescaled remainder functions at strong coupling with those at two, three and four loops, and find that they are close to each other along the trajectories parameterized by the scale parameter of the integrable model.

Unraveling cyclic deformation mechanisms of a rolled magnesium alloy using in situ neutron diffraction

DOE PAGES

Wu, Wei; An, Ke; Liaw, Peter K.

2014-12-23

In the current study, the deformation mechanisms of a rolled magnesium alloy were investigated under cyclic loading using real-time in situ neutron diffraction under a continuous-loading condition. The relationship between the macroscopic cyclic deformation behavior and the microscopic response at the grain level was established. The neutron diffraction results indicate that more and more grains are involved in the twinning and detwinning deformation process with the increase of fatigue cycles. The residual twins appear in the early fatigue life, which is responsible for the cyclic hardening behavior. The asymmetric shape of the hysteresis loop is attributed to the early exhaustionmore » of the detwinning process during compression, which leads to the activation of dislocation slips and rapid strain-hardening. The critical resolved shear stress for the activation of tensile twinning closely depends on the residual strain developed during cyclic loading. In the cycle before the sample fractured, the dislocation slips became active in tension, although the sample was not fully twinned. The increased dislocation density leads to the rise of the stress concentration at weak spots, which is believed to be the main reason for the fatigue failure. Furthermore, the deformation history greatly influences the deformation mechanisms of hexagonal-close-packed-structured magnesium alloy during cyclic loading.« less

Alleviation of whirl-flutter on a joined-wing tilt-rotor aircraft configuration using active controls

NASA Technical Reports Server (NTRS)

Vanaken, Johannes M.

1991-01-01

The feasibility of using active controls to delay the onset of whirl-flutter on a joined-wing tilt rotor aircraft was investigated. The CAMRAD/JA code was used to obtain a set of linear differential equations which describe the motion of the joined-wing tilt-rotor aircraft. The hub motions due to wing/body motion is a standard input to CAMRAD/JA and were obtained from a structural dynamics model of a representative joined-wing tilt-rotor aircraft. The CAMRAD/JA output, consisting of the open-loop system matrices, and the airframe free vibration motion were input to a separate program which performed the closed-loop, active control calculations. An eigenvalue analysis was performed to determine the flutter stability of both open- and closed-loop systems. Sensor models, based upon the feedback of pure state variables and based upon hub-mounted sensors, providing physically measurable accelerations, were evaluated. It was shown that the onset of tilt-rotor whirl-flutter could be delayed from 240 to above 270 knots by feeding back vertical and span-wise accelerations, measured at the rotor hub, to the longitudinal cyclic pitch. Time response calculations at a 270-knot cruise condition showed an active cyclic pitch control level of 0.009 deg, which equates to a very acceptable 9 pound active-control force applied at the rotor hub.

A novel method for reducing gap formation in tendon repair.

PubMed

Dean, Ryan; Sethi, Paul

2018-03-01

This study investigates gap formation in tendon repair using a novel tensioning method. The novel stitch will demonstrate less gap formation than the other suture configurations tested. Porcine tendons stitched with classic Krackow stitch configurations were compared to a Krackow stitch modified with a proximal Tension-Assist Loop. Each group was cyclically loaded followed by analysis of the tendon-suture construct for gap formation. The Tension-Assist Loop group produced significantly less gap formation than each of the other stitch groups. Decreasing early gap formation may be beneficial in allowing early rehabilitation and range of motion.

Antigenic peptides containing large PEG loops designed to extend out of the HLA-A2 binding site form stable complexes with class I major histocompatibility complex molecules.

PubMed Central

Bouvier, M; Wiley, D C

1996-01-01

Recognition of peptides bound to class I major histocompatibility complex (MHC) molecules by specific receptors on T cells regulates the development and activity of the cellular immune system. We have designed and synthesized de novo cyclic peptides that incorporate PEG in the ring structure for binding to class I MHC molecules. The large PEG loops are positioned to extend out of the peptide binding site, thus creating steric effects aimed at preventing the recognition of class I MHC complexes by T-cell receptors. Peptides were synthesized and cyclized on polymer support using high molecular weight symmetrical PEG dicarboxylic acids to link the side chains of lysine residues substituted at positions 4 and 8 in the sequence of the HLA-A2-restricted human T-lymphotrophic virus type I Tax peptide. Cyclic peptides promoted the in vitro folding and assembly of HLA-A2 complexes. Thermal denaturation studies using circular dichroism spectroscopy showed that these complexes are as stable as complexes formed with antigenic peptides. Images Fig. 2 Fig. 4 PMID:8643447

Crystal structure of a looped-chain CoII coordination polymer: catena-poly[[bis-(nitrato-κO)cobalt(II)]bis-[μ-bis-(pyridin-3-ylmeth-yl)sulfane-κ2N:N'

PubMed

Moon, Suk-Hee; Seo, Joobeom; Park, Ki-Min

2017-11-01

The asymmetric unit of the title compound, [Co(NO 3 ) 2 (C 12 H 12 N 2 S) 2 ] n , contains a bis-(pyridin-3-ylmeth-yl)sulfane ( L ) ligand, an NO 3 - anion and half a Co II cation, which lies on an inversion centre. The Co II cation is six-coordinated, being bound to four pyridine N atoms from four symmetry-related L ligands. The remaining coordination sites are occupied by two O atoms from two symmetry-related nitrate anions in a monodentate manner. Thus, the Co II centre adopts a distorted octa-hedral geometry. Two symmetry-related L ligands are connected by two symmetry-related Co II cations, forming a 20-membered cyclic dimer, in which the Co II atoms are separated by 10.2922 (7) Å. The cyclic dimers are connected to each other by sharing Co II atoms, giving rise to the formation of an infinite looped chain propagating along the [101] direction. Inter-molecular C-H⋯π (H⋯ring centroid = 2.89 Å) inter-actions between one pair of corresponding L ligands and C-H⋯O hydrogen bonds between the L ligands and the nitrate anions occur in the looped chain. In the crystal, adjacent looped chains are connected by inter-molecular π-π stacking inter-actions [centroid-to-centroid distance = 3.8859 (14) Å] and C-H⋯π hydrogen bonds (H⋯ring centroid = 2.65 Å), leading to the formation of layers parallel to (101). These layers are further connected through C-H⋯O hydrogen bonds between the layers, resulting in the formation of a three-dimensional supra-molecular architecture.

Flat-Cladding Fiber Bragg Grating Sensors for Large Strain Amplitude Fatigue Tests

PubMed Central

Feng, Aihen; Chen, Daolun; Li, Cheng; Gu, Xijia

2010-01-01

We have successfully developed a flat-cladding fiber Bragg grating sensor for large cyclic strain amplitude tests of up to ±8,000 με. The increased contact area between the flat-cladding fiber and substrate, together with the application of a new bonding process, has significantly increased the bonding strength. In the push-pull fatigue tests of an aluminum alloy, the plastic strain amplitudes measured by three optical fiber sensors differ only by 0.43% at a cyclic strain amplitude of ±7,000 με and 1.9% at a cyclic strain amplitude of ±8,000 με. We also applied the sensor on an extruded magnesium alloy for evaluating the peculiar asymmetric hysteresis loops. The results obtained were in good agreement with those measured from the extensometer, a further validation of the sensor. PMID:22163621

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, L.; Qian, S.-B.; Zhu, L.-Y.

The secured four-color light curves of VW Boo were analyzed with the 2003 version of the Wilson-Devinney code. It is confirmed that VW Boo is a shallow W-type contact binary system with a degree of contact factor f = 10.8%({+-} 0.5%). Two dark spots were found on the massive cool component this time. They cause an unequal depth of the two maxima. A period investigation based on all available visual, photographic, CCD, and photoelectric data shows that the period of the system includes a long-term decrease (dP/dt = -1.454 x 10{sup -7} days yr{sup -1}) and an oscillation (A{sub 3}more » = 0.0059 days; T{sub 3} = 25.96 years). These may be caused by mass transfer, angular momentum loss, and cyclic magnetic activity.« less

Spectrum of the Wilson Dirac operator at finite lattice spacings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akemann, G.; Damgaard, P. H.; Splittorff, K.

2011-04-15

We consider the effect of discretization errors on the microscopic spectrum of the Wilson Dirac operator using both chiral perturbation theory and chiral random matrix theory. A graded chiral Lagrangian is used to evaluate the microscopic spectral density of the Hermitian Wilson Dirac operator as well as the distribution of the chirality over the real eigenvalues of the Wilson Dirac operator. It is shown that a chiral random matrix theory for the Wilson Dirac operator reproduces the leading zero-momentum terms of Wilson chiral perturbation theory. All results are obtained for a fixed index of the Wilson Dirac operator. The low-energymore » constants of Wilson chiral perturbation theory are shown to be constrained by the Hermiticity properties of the Wilson Dirac operator.« less

Power counting and modes in SCET

NASA Astrophysics Data System (ADS)

Goerke, Raymond; Luke, Michael

2018-02-01

We present a formulation of soft-collinear effective theory (SCET) in the two-jet sector as a theory of decoupled sectors of QCD coupled to Wilson lines. The formulation is manifestly boost-invariant, does not require the introduction of ultrasoft modes at the hard matching scale Q, and has manifest power counting in inverse powers of Q. The spurious infrared divergences which arise in SCET when ultrasoft modes are not included in loops disappear when the overlap between the sectors is correctly subtracted, in a manner similar to the familiar zero-bin subtraction of SCET. We illustrate this approach by analyzing deep inelastic scattering in the endpoint region in SCET and comment on other applications.

Trojan penguins and isospin violation in hadronic B decays

NASA Astrophysics Data System (ADS)

Grossman, Yuval; Neubert, Matthias; Kagan, Alexander L.

1999-10-01

Some rare hadronic decays of B mesons, such as B→πK, are sensitive to isospin-violating contributions from physics beyond the Standard Model. Although commonly referred to as electroweak penguins, such contributions can often arise through tree-level exchanges of heavy particles, or through strong-interaction loop diagrams. The Wilson coefficients of the corresponding electroweak penguin operators are calculated in a large class of New Physics models, and in many cases are found not to be suppressed with respect to the QCD penguin coefficients. Several tests for these effects using observables in B+/-→πK decays are discussed, and nontrivial bounds on the couplings of the various New Physics models are derived.

Proton spin: A topological invariant

NASA Astrophysics Data System (ADS)

Tiwari, S. C.

2016-11-01

Proton spin problem is given a new perspective with the proposition that spin is a topological invariant represented by a de Rham 3-period. The idea is developed generalizing Finkelstein-Rubinstein theory for Skyrmions/kinks to topological defects, and using non-Abelian de Rham theorems. Two kinds of de Rham theorems are discussed applicable to matrix-valued differential forms, and traces. Physical and mathematical interpretations of de Rham periods are presented. It is suggested that Wilson lines and loop operators probe the local properties of the topology, and spin as a topological invariant in pDIS measurements could appear with any value from 0 to ℏ 2, i.e. proton spin decomposition has no meaning in this approach.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huey-Wen Lin; Robert G. Edwards; Balint Joo

In this work, we perform parameter tuning with dynamical anisotropic clover lattices using the Schr\\"odinger functional and stout-smearing in the fermion field. We find thatmore » $$\\xi_R/\\xi_0$$ is relatively close to 1 in our parameter search, which allows us to fix $$\\xi_0$$ in our runs. We proposed to determine the gauge and fermion anisotropy in a Schr\\"odinger-background small box using Wilson loop ratios and PCAC masses. We demonstrate that these ideas are equivalent to but more efficient than the conventional meson dispersion approach. The spatial and temporal clover coefficients are fixed to the tree-level tadpole-improved clover values, and we demonstrate that they satisfy the nonperturbative condition determined by Schr\\"odinger functional method.« less

Dynamical Chern-Simons Theory in the Brillouin Zone

NASA Astrophysics Data System (ADS)

Lian, Biao; Vafa, Cumrun; Vafa, Farzan; Zhang, Shou-Cheng

Berry connection is conventionally defined as a static gauge field in the Brillouin zone. Here we show that for three-dimensional (3d) time-reversal invariant superconductors, a generalized Berry gauge field behaves as a dynamical fluctuating field of a Chern-Simons gauge theory. The gapless nodal lines in the momentum space play the role of Wilson loop observables, while their linking and knot invariants modify the gravitational theta angle. This angle induces a topological gravitomagnetoelectric effect where a temperature gradient induces a rotational energy flow. We also show how topological strings may be realized in the 6 dimensional phase space, where the physical space defects play the role of topological D-branes.

Holographic repulsion and confinement in gauge theory

NASA Astrophysics Data System (ADS)

Husain, Viqar; Kothawala, Dawood

2013-02-01

We show that for asymptotically anti-de Sitter (AdS) backgrounds with negative energy, such as the AdS soliton and regulated negative-mass AdS-Schwarzshild metrics, the Wilson loop expectation value in the AdS/CFT conjecture exhibits a Coulomb to confinement transition. We also show that the quark-antiquark (q \\bar{q}) potential can be interpreted as affine time along null geodesics on the minimal string worldsheet and that its intrinsic curvature provides a signature of transition to confinement phase. Our results suggest a generic (holographic) relationship between confinement in gauge theory and repulsive gravity, which in turn is connected with singularity avoidance in quantum gravity. Communicated by P R L V Moniz

The Situation in Industry and the Loss of Interest in Science Education

ERIC Educational Resources Information Center

HAAS, JOACHIM

2005-01-01

The case of Germany is taken as an example of cyclical variation in higher education enrolment in the sciences. The article argues that the mechanism underpinning these fluctuations is the cobweb model. This model establishes a recursive loop between trends in enrolments in a discipline and trends in the labour market associated with this…

The Situation in Industry and the Loss of Interest in Science Education

ERIC Educational Resources Information Center

Haas, Joachim

2005-01-01

The case of Germany is taken as an example of cyclical variation in higher education enrolment in the sciences. This article looks at the causes of this "oscillation," focusing on the cycle of the 1990s and argues that the mechanism underpinning these fluctuations is the cobweb model. This model establishes a recursive loop between…

Aromatic Ring Currents Illustrated--NMR Spectra of Tin(IV) Porphyrin Complexes. An Advanced Undergraduate Experiment.

ERIC Educational Resources Information Center

Arnold, Dennis P.

1988-01-01

Attempts to show that in the closed loops of cyclic structures the protons situated in conic regions above and below the ring will be shielded. Uses the diamagnetic and air stable octahedral tin(IV) complexes of porphyrins for study. Notes complexes crystallize easily and offer spectacular purple colors. (MVL)

Cyclic Mario worlds — color-decomposition for one-loop QCD

NASA Astrophysics Data System (ADS)

Kälin, Gregor

2018-04-01

We present a new color decomposition for QCD amplitudes at one-loop level as a generalization of the Del Duca-Dixon-Maltoni and Johansson-Ochirov decomposition at tree level. Starting from a minimal basis of planar primitive amplitudes we write down a color decomposition that is free of linear dependencies among appearing primitive amplitudes or color factors. The conjectured decomposition applies to any number of quark flavors and is independent of the choice of gauge group and matter representation. The results also hold for higher-dimensional or supersymmetric extensions of QCD. We provide expressions for any number of external quark-antiquark pairs and gluons. [Figure not available: see fulltext.

Renormalization of Supersymmetric QCD on the Lattice

NASA Astrophysics Data System (ADS)

Costa, Marios; Panagopoulos, Haralambos

2018-03-01

We perform a pilot study of the perturbative renormalization of a Supersymmetric gauge theory with matter fields on the lattice. As a specific example, we consider Supersymmetric N=1 QCD (SQCD). We study the self-energies of all particles which appear in this theory, as well as the renormalization of the coupling constant. To this end we compute, perturbatively to one-loop, the relevant two-point and three-point Green's functions using both dimensional and lattice regularizations. Our lattice formulation involves theWilson discretization for the gluino and quark fields; for gluons we employ the Wilson gauge action; for scalar fields (squarks) we use naive discretization. The gauge group that we consider is SU(Nc), while the number of colors, Nc, the number of flavors, Nf, and the gauge parameter, α, are left unspecified. We obtain analytic expressions for the renormalization factors of the coupling constant (Zg) and of the quark (ZΨ), gluon (Zu), gluino (Zλ), squark (ZA±), and ghost (Zc) fields on the lattice. We also compute the critical values of the gluino, quark and squark masses. Finally, we address the mixing which occurs among squark degrees of freedom beyond tree level: we calculate the corresponding mixing matrix which is necessary in order to disentangle the components of the squark field via an additional finite renormalization.

Supersymmetric QCD on the lattice: An exploratory study

NASA Astrophysics Data System (ADS)

Costa, M.; Panagopoulos, H.

2017-08-01

We perform a pilot study of the perturbative renormalization of a supersymmetric gauge theory with matter fields on the lattice. As a specific example, we consider supersymmetric N =1 QCD (SQCD). We study the self-energies of all particles which appear in this theory, as well as the renormalization of the coupling constant. To this end we compute, perturbatively to one-loop, the relevant two-point and three-point Green's functions using both dimensional and lattice regularizations. Our lattice formulation involves the Wilson discretization for the gluino and quark fields; for gluons we employ the Wilson gauge action; for scalar fields (squarks) we use naïve discretization. The gauge group that we consider is S U (Nc), while the number of colors, Nc, the number of flavors, Nf, and the gauge parameter, α , are left unspecified. We obtain analytic expressions for the renormalization factors of the coupling constant (Zg) and of the quark (Zψ), gluon (Zu), gluino (Zλ), squark (ZA ±), and ghost (Zc) fields on the lattice. We also compute the critical values of the gluino, quark and squark masses. Finally, we address the mixing which occurs among squark degrees of freedom beyond tree level: we calculate the corresponding mixing matrix which is necessary in order to disentangle the components of the squark field via an additional finite renormalization.

The Virtues in John Wilson's Approach to Moral Education.

ERIC Educational Resources Information Center

Tobin, Bernadette

2000-01-01

Explores John Wilson's ideas on moral education, arguing against Wilson's criticism of virtue theory. Evaluates Wilson's account of moral education from the perspective of a neo-Aristotelian sense of morality and moral development. Focuses on a part of Wilson's work, "A New Introduction to Moral Education." (CMK)

Energy theorem for (2+1)-dimensional gravity.

NASA Astrophysics Data System (ADS)

Menotti, P.; Seminara, D.

1995-05-01

We prove a positive energy theorem in (2+1)-dimensional gravity for open universes and any matter energy-momentum tensor satisfying the dominant energy condition. We consider on the space-like initial value surface a family of widening Wilson loops and show that the energy-momentum of the enclosed subsystem is a future directed time-like vector whose mass is an increasing function of the loop, until it reaches the value 1/4G corresponding to a deficit angle of 2π. At this point the energy-momentum of the system evolves, depending on the nature of a zero norm vector appearing in the evolution equations, either into a time-like vector of a universe which closes kinematically or into a Gott-like universe whose energy momentum vector, as first recognized by Deser, Jackiw, and 't Hooft (1984) is space-like. This treatment generalizes results obtained by Carroll, Fahri, Guth, and Olum (1994) for a system of point-like spinless particle, to the most general form of matter whose energy-momentum tensor satisfies the dominant energy condition. The treatment is also given for the anti-de Sitter (2+1)-dimensional gravity.

Machine learning Z2 quantum spin liquids with quasiparticle statistics

NASA Astrophysics Data System (ADS)

Zhang, Yi; Melko, Roger G.; Kim, Eun-Ah

2017-12-01

After decades of progress and effort, obtaining a phase diagram for a strongly correlated topological system still remains a challenge. Although in principle one could turn to Wilson loops and long-range entanglement, evaluating these nonlocal observables at many points in phase space can be prohibitively costly. With growing excitement over topological quantum computation comes the need for an efficient approach for obtaining topological phase diagrams. Here we turn to machine learning using quantum loop topography (QLT), a notion we have recently introduced. Specifically, we propose a construction of QLT that is sensitive to quasiparticle statistics. We then use mutual statistics between the spinons and visons to detect a Z2 quantum spin liquid in a multiparameter phase space. We successfully obtain the quantum phase boundary between the topological and trivial phases using a simple feed-forward neural network. Furthermore, we demonstrate advantages of our approach for the evaluation of phase diagrams relating to speed and storage. Such statistics-based machine learning of topological phases opens new efficient routes to studying topological phase diagrams in strongly correlated systems.

A 56 million year rhythm in North American sedimentation during the Phanerozoic

NASA Astrophysics Data System (ADS)

Meyers, Stephen R.; Peters, Shanan E.

2011-03-01

Long-term (> 10 Myr) fluctuations in climate, sea-level and sedimentation have been documented in the stratigraphic record, but the lack of well-constrained data series has made it difficult to rigorously evaluate cyclic (periodic or quasi-periodic) changes at this scale. Here we utilize a new compilation of the coverage area of sedimentary rocks in North America to investigate the dominant modes (“orders”) of stratigraphic variability, and to evaluate potential long-period cyclic changes in sedimentation on the continent during the Phanerozoic. Our analysis resolves two principal temporal modes of variability: (1) a strongly sinusoidal mode with a periodicity of 56 Myr +/- 3 Myr, and (2) a longer-term Phanerozoic mode (the “M-curve”, linked to the Wilson cycle), which is indistinguishable from a stochastic autoregressive process. The newly identified 56 Myr cycle in sedimentation delineates most of the cratonic sequences that have previously been identified qualitatively in North America, but here we propose a quantitative redefinition that includes nine distinct units and two mega-sequences. The timing of the 56 Myr beat in sedimentation is consistent with an orogenic oscillator source or an oscillatory dynamic in mantle convection, and its tempo is statistically similar to a known rhythm in number of marine animal genera in the global fossil record. Thus, the identification of a significant periodic signal in the sedimentary record of North America provides new evidence for an important tectonic- and/or mantle-scale cyclic process that links both large-scale biological evolution and physical environmental change.

Stress-strain time-dependent behavior of A356.0 aluminum alloy subjected to cyclic thermal and mechanical loadings

NASA Astrophysics Data System (ADS)

Farrahi, G. H.; Ghodrati, M.; Azadi, M.; Rezvani Rad, M.

2014-08-01

This article presents the cyclic behavior of the A356.0 aluminum alloy under low-cycle fatigue (or isothermal) and thermo-mechanical fatigue loadings. Since the thermo-mechanical fatigue (TMF) test is time consuming and has high costs in comparison to low-cycle fatigue (LCF) tests, the purpose of this research is to use LCF test results to predict the TMF behavior of the material. A time-independent model, considering the combined nonlinear isotropic/kinematic hardening law, was used to predict the TMF behavior of the material. Material constants of this model were calibrated based on room-temperature and high-temperature low-cycle fatigue tests. The nonlinear isotropic/kinematic hardening law could accurately estimate the stress-strain hysteresis loop for the LCF condition; however, for the out-of-phase TMF, the condition could not predict properly the stress value due to the strain rate effect. Therefore, a two-layer visco-plastic model and also the Johnson-Cook law were applied to improve the estimation of the stress-strain hysteresis loop. Related finite element results based on the two-layer visco-plastic model demonstrated a good agreement with experimental TMF data of the A356.0 alloy.

Air-flow regulation system for a coal gasifier

DOEpatents

Fasching, George E.

1984-01-01

An improved air-flow regulator for a fixed-bed coal gasifier is provided which allows close air-flow regulation from a compressor source even though the pressure variations are too rapid for a single primary control loop to respond. The improved system includes a primary controller to control a valve in the main (large) air supply line to regulate large slow changes in flow. A secondary controller is used to control a smaller, faster acting valve in a secondary (small) air supply line parallel to the main line valve to regulate rapid cyclic deviations in air flow. A low-pass filter with a time constant of from 20 to 50 seconds couples the output of the secondary controller to the input of the primary controller so that the primary controller only responds to slow changes in the air-flow rate, the faster, cyclic deviations in flow rate sensed and corrected by the secondary controller loop do not reach the primary controller due to the high frequency rejection provided by the filter. This control arrangement provides at least a factor of 5 improvement in air-flow regulation for a coal gasifier in which air is supplied by a reciprocating compressor through a surge tank.

Comparison of Cyclic Hysteresis Behavior between Cross-Ply C/SiC and SiC/SiC Ceramic-Matrix Composites

PubMed Central

Li, Longbiao

2016-01-01

In this paper, the comparison of cyclic hysteresis behavior between cross-ply C/SiC and SiC/SiC ceramic-matrix composites (CMCs) has been investigated. The interface slip between fibers and the matrix existed in the matrix cracking mode 3 and mode 5, in which matrix cracking and interface debonding occurred in the 0° plies are considered as the major reason for hysteresis loops of cross-ply CMCs. The hysteresis loops of cross-ply C/SiC and SiC/SiC composites corresponding to different peak stresses have been predicted using present analysis. The damage parameter, i.e., the proportion of matrix cracking mode 3 in the entire matrix cracking modes of the composite, and the hysteresis dissipated energy increase with increasing peak stress. The damage parameter and hysteresis dissipated energy of C/SiC composite under low peak stress are higher than that of SiC/SiC composite; However, at high peak stress, the damage extent inside of cross-ply SiC/SiC composite is higher than that of C/SiC composite as more transverse cracks and matrix cracks connect together. PMID:28787861

Comparison of Cyclic Hysteresis Behavior between Cross-Ply C/SiC and SiC/SiC Ceramic-Matrix Composites.

PubMed

Li, Longbiao

2016-01-19

In this paper, the comparison of cyclic hysteresis behavior between cross-ply C/SiC and SiC/SiC ceramic-matrix composites (CMCs) has been investigated. The interface slip between fibers and the matrix existed in the matrix cracking mode 3 and mode 5, in which matrix cracking and interface debonding occurred in the 0° plies are considered as the major reason for hysteresis loops of cross-ply CMCs. The hysteresis loops of cross-ply C/SiC and SiC/SiC composites corresponding to different peak stresses have been predicted using present analysis. The damage parameter, i.e. , the proportion of matrix cracking mode 3 in the entire matrix cracking modes of the composite, and the hysteresis dissipated energy increase with increasing peak stress. The damage parameter and hysteresis dissipated energy of C/SiC composite under low peak stress are higher than that of SiC/SiC composite; However, at high peak stress, the damage extent inside of cross-ply SiC/SiC composite is higher than that of C/SiC composite as more transverse cracks and matrix cracks connect together.

Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels.

PubMed

Korkosh, V S; Zhorov, B S; Tikhonov, D B

2016-05-01

The family of P-loop channels includes potassium, sodium, calcium, cyclic nucleotide-gated and TRPV channels, as well as ionotropic glutamate receptors. Despite vastly different physiological and pharmacological properties, the channels have structurally conserved folding of the pore domain. Furthermore, crystallographic data demonstrate surprisingly similar mutual disposition of transmembrane and membrane-diving helices. To understand determinants of this conservation, here we have compared available high-resolution structures of sodium, potassium, and TRPV1 channels. We found that some residues, which are in matching positions of the sequence alignment, occur in different positions in the 3D alignment. Surprisingly, we found 3D mismatches in well-packed P-helices. Analysis of energetics of individual residues in Monte Carlo minimized structures revealed cyclic patterns of energetically favorable inter- and intra-subunit contacts of P-helices with S6 helices. The inter-subunit contacts are rather conserved in all the channels, whereas the intra-subunit contacts are specific for particular types of the channels. Our results suggest that these residue-residue contacts contribute to the folding stabilization. Analysis of such contacts is important for structural and phylogenetic studies of homologous proteins.

One-Loop One-Point Functions in Gauge-Gravity Dualities with Defects.

PubMed

Buhl-Mortensen, Isak; de Leeuw, Marius; Ipsen, Asger C; Kristjansen, Charlotte; Wilhelm, Matthias

2016-12-02

We initiate the calculation of loop corrections to correlation functions in 4D defect conformal field theories (dCFTs). More precisely, we consider N=4 SYM theory with a codimension-one defect separating two regions of space, x_{3}>0 and x_{3}<0, where the gauge group is SU(N) and SU(N-k), respectively. This setup is made possible by some of the real scalar fields acquiring a nonvanishing and x_{3}-dependent vacuum expectation value for x_{3}>0. The holographic dual is the D3-D5 probe brane system where the D5-brane geometry is AdS_{4}×S^{2} and a background gauge field has k units of flux through the S^{2}. We diagonalize the mass matrix of the dCFT making use of fuzzy-sphere coordinates and we handle the x_{3} dependence of the mass terms in the 4D Minkowski space propagators by reformulating these as standard massive AdS_{4} propagators. Furthermore, we show that only two Feynman diagrams contribute to the one-loop correction to the one-point function of any single-trace operator and we explicitly calculate this correction in the planar limit for the simplest chiral primary. The result of this calculation is compared to an earlier string-theory computation in a certain double scaling limit and perfect agreement is found. Finally, we discuss how to generalize our calculation to any single-trace operator, to finite N, and to other types of observables such as Wilson loops.

Multi-color light curves and orbital period research of eclipsing binary V1073 Cyg

NASA Astrophysics Data System (ADS)

Tian, Xiao-Man; Zhu, Li-Ying; Qian, Sheng-Bang; Li, Lin-Jia; Jiang, Lin-Qiao

2018-02-01

New multi-color BV RcIc photometric observations are presented for the W UMa type eclipsing binary V1073 Cyg. The multi-color light curve analysis with the Wilson-Devinney procedure yielded the absolute parameters of this system, showing that V1073 Cyg is a shallow contact binary system with a fill-out factor f = 0.124(±0.011). We collected all available times of light minima spanning 119 yr, including CCD data to construct the O ‑ C curve, and performed detailed O ‑ C analysis. The O ‑ C diagram shows that the period change is complex. A long-term continuous decrease and a cyclic variation exist. The period is decreasing at a rate of Ṗ = ‑1.04(±0.18) × 10‑10 d cycle‑1 and, with the period decrease, V1073 Cyg will evolve to the deep contact stage. The cyclic variation with a period of P 3 = 82.7(±3.6) yr and an amplitude of A = 0.028(±0.002)d may be explained by magnetic activity of one or both components or the light travel time effect caused by a distant third companion with M 3(i‧ = 90°) = 0.511 M⊙.

Multiple loop conformations of peptides predicted by molecular dynamics simulations are compatible with nuclear magnetic resonance.

PubMed

Carstens, Heiko; Renner, Christian; Milbradt, Alexander G; Moroder, Luis; Tavan, Paul

2005-03-29

The affinity and selectivity of protein-protein interactions can be fine-tuned by varying the size, flexibility, and amino acid composition of involved surface loops. As a model for such surface loops, we study the conformational landscape of an octapeptide, whose flexibility is chemically steered by a covalent ring closure integrating an azobenzene dye into and by a disulfide bridge additionally constraining the peptide backbone. Because the covalently integrated azobenzene dyes can be switched by light between a bent cis state and an elongated trans state, six cyclic peptide models of strongly different flexibilities are obtained. The conformational states of these peptide models are sampled by NMR and by unconstrained molecular dynamics (MD) simulations. Prototypical conformations and the free-energy landscapes in the high-dimensional space spanned by the phi/psi angles at the peptide backbone are obtained by clustering techniques from the MD trajectories. Multiple open-loop conformations are shown to be predicted by MD particularly in the very flexible cases and are shown to comply with the NMR data despite the fact that such open-loop conformations are missing in the refined NMR structures.

Cyclic compression response of micropillars extracted from textured nanocrystalline NiTi thin-walled tubes

DOE PAGES

Ghassemi-Armaki, Hassan; Leff, Asher C.; Taheri, Mitra L.; ...

2017-06-22

Compression-compression cyclic deformation of nanocrystalline NiTi tubes intended for medical stents and with an outer diameter of 1 mm and wall thickness of 70 μm was studied using micropillars produced by FIB with the loading axis orthogonal to the tube axis. These micropillars were cycled in a displacement-controlled mode using a nanoindenter equipped with a flat punch to strain levels of 4, 6 and 8% in each cycle and specimens were subjected to several hundred cycles. Furthermore, the cyclic response of two NiTi tubes, one with Af of 17 °C and the other with an Af of -5 °C ismore » compared. The texture of the tube with the Af of -5 °C was measured at the microscopic level using transmission electron microscopy and at the macroscopic level by X-ray diffraction and good agreement was noted. Characteristics such as i) a reduction in the forward transformation stress, ii) increase in maximum stress for a given displacement amplitude, and iii) a reduction in the hysteresis loop area, all with increasing number of cycles, observed typically during cyclic deformation of conventional macroscopic specimens, were captured in the micropillar cyclic tests. Our observations lead to the conclusion that micropillar compression testing in a cyclic mode can enable characterizing the orientation-dependent response in such small dimension components that see complex loading in service, and additionally provide an opportunity for calibrating constitutive equations in micromechanical models.« less

Cyclic deformation leads to defect healing and strengthening of small-volume metal crystals

DOE PAGES

Wang, Zhang-Jie; Li, Qing-Jie; Cui, Yi-Nan; ...

2015-10-19

When microscopic and macroscopic specimens of metals are subjected to cyclic loading, the creation, interaction, and accumulation of defects lead to damage, cracking, and failure. We demonstrate that when aluminum single crystals of submicrometer dimensions are subjected to low-amplitude cyclic deformation at room temperature, the density of preexisting dislocation lines and loops can be dramatically reduced with virtually no change of the overall sample geometry and essentially no permanent plastic strain. Furthermore, this “cyclic healing” of the metal crystal leads to significant strengthening through dramatic reductions in dislocation density, in distinct contrast to conventional cyclic strain hardening mechanisms arising frommore » increases in dislocation density and interactions among defects in microcrystalline and macrocrystalline metals and alloys. Our real-time, in situ transmission electron microscopy observations of tensile tests reveal that pinned dislocation lines undergo shakedown during cyclic straining, with the extent of dislocation unpinning dependent on the amplitude, sequence, and number of strain cycles. Those unpinned mobile dislocations moving close enough to the free surface of the thin specimens as a result of such repeated straining are then further attracted to the surface by image forces that facilitate their egress from the crystal. Our results point to a versatile pathway for controlled mechanical annealing and defect engineering in submicrometer-sized metal crystals, thereby obviating the need for thermal annealing or significant plastic deformation that could cause change in shape and/or dimensions of the specimen.« less

Cyclic deformation leads to defect healing and strengthening of small-volume metal crystals

PubMed Central

Wang, Zhang-Jie; Li, Qing-Jie; Cui, Yi-Nan; Liu, Zhan-Li; Ma, Evan; Li, Ju; Sun, Jun; Zhuang, Zhuo; Dao, Ming; Shan, Zhi-Wei; Suresh, Subra

2015-01-01

When microscopic and macroscopic specimens of metals are subjected to cyclic loading, the creation, interaction, and accumulation of defects lead to damage, cracking, and failure. Here we demonstrate that when aluminum single crystals of submicrometer dimensions are subjected to low-amplitude cyclic deformation at room temperature, the density of preexisting dislocation lines and loops can be dramatically reduced with virtually no change of the overall sample geometry and essentially no permanent plastic strain. This “cyclic healing” of the metal crystal leads to significant strengthening through dramatic reductions in dislocation density, in distinct contrast to conventional cyclic strain hardening mechanisms arising from increases in dislocation density and interactions among defects in microcrystalline and macrocrystalline metals and alloys. Our real-time, in situ transmission electron microscopy observations of tensile tests reveal that pinned dislocation lines undergo shakedown during cyclic straining, with the extent of dislocation unpinning dependent on the amplitude, sequence, and number of strain cycles. Those unpinned mobile dislocations moving close enough to the free surface of the thin specimens as a result of such repeated straining are then further attracted to the surface by image forces that facilitate their egress from the crystal. These results point to a versatile pathway for controlled mechanical annealing and defect engineering in submicrometer-sized metal crystals, thereby obviating the need for thermal annealing or significant plastic deformation that could cause change in shape and/or dimensions of the specimen. PMID:26483463

Variations in Ratio and Correlation of Solar Magnetic Fields in the Fe i 525.02 nm and Na i 589.59 nm Lines According to Mount Wilson Measurements During 2000 - 2012

NASA Astrophysics Data System (ADS)

Golubeva, Elena

2016-10-01

Variations in the solar magnetic-field ratio over 13 years are analyzed, relying on the comparison of simultaneous measurements in two spectral lines at the Mount Wilson Observatory (MWO). The ratio and correlation coefficient are calculated over the general working range of measured magnetic-field values and in various ranges of the field magnitudes. Variations in both parameters are considered. We found the following tendencies: i) the parameters show changes with the cycle of solar activity in the general case; ii) their dependence on magnetic-field magnitude is a nonlinear function of time, and this is especially pronounced in the ratio behavior; iii) several separate ranges of the field magnitudes can be distinguished based on the behavioral patterns of the ratio variations. Correspondences between these ranges and the known structural objects of the solar atmosphere are discussed. This permits us to reach the conclusion that the dependence of parameters considered on the magnetic-field magnitude and time is connected with the variety of magnetic structural components and their cyclic rearrangements. The results represented may be useful for solving interpretation problems of solar magnetic-field measurements and for the cross-calibration of applicable instruments. They can also be of interest for tasks related to the creation of a uniform long temporal series of solar magnetic-field data from various sources.

Field testing of stiffened deep cement mixing piles under lateral cyclic loading

NASA Astrophysics Data System (ADS)

Raongjant, Werasak; Jing, Meng

2013-06-01

Construction of seaside and underground wall bracing often uses stiffened deep cement mixed columns (SDCM). This research investigates methods used to improve the level of bearing capacity of these SDCM when subjected to cyclic lateral loading via various types of stiffer cores. Eight piles, two deep cement mixed piles and six stiffened deep cement mixing piles with three different types of cores, H shape cross section prestressed concrete, steel pipe, and H-beam steel, were embedded though soft clay into medium-hard clay on site in Thailand. Cyclic horizontal loading was gradually applied until pile failure and the hysteresis loops of lateral load vs. lateral deformation were recorded. The lateral carrying capacities of the SDCM piles with an H-beam steel core increased by 3-4 times that of the DCM piles. This field research clearly shows that using H-beam steel as a stiffer core for SDCM piles is the best method to improve its lateral carrying capacity, ductility and energy dissipation capacity.

Low cycle fatigue behavior of a ferritic reactor pressure vessel steel

NASA Astrophysics Data System (ADS)

Sarkar, Apu; Kumawat, Bhupendra K.; Chakravartty, J. K.

2015-07-01

The cyclic stress-strain response and the low cycle fatigue (LCF) behavior of 20MnMoNi55 pressure vessel steel were studied. Tensile strength and LCF properties were examined at room temperature (RT) using specimens cut from rolling direction of a rolled block. The fully reversed strain-controlled LCF tests were conducted at a constant total strain rate with different axial strain amplitude levels. The cyclic strain-stress relationships and the strain-life relationships were obtained through the test results, and related LCF parameters of the steel were calculated. The studied steel exhibits cyclic softening behavior. Furthermore, analysis of stabilized hysteresis loops showed that the steel exhibits non-Masing behavior. Complementary scanning electron microscopy examinations were also carried out on fracture surfaces to reveal dominant damage mechanisms during crack initiation, propagation and fracture. Multiple crack initiation sites were observed on the fracture surface. The investigated LCF behavior can provide reference for pressure vessel life assessment and fracture mechanisms analysis.

Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.

PubMed

Chen, Xia; Liu, Liu; Chen, Yong; Yang, Yuting; Yang, Chao-Yie; Guo, Tianyue; Lei, Ming; Sun, Haiying; Wang, Shaomeng

2018-05-10

Telomeric repeat binding factor 2 (TRF2) is a telomere-associated protein that plays an important role in the formation of the 3' single strand DNA overhang and the "T loop", two structures critical for the stability of the telomeres. Apollo is a 5'-exonuclease recruited by TRF2 to the telomere and contributes to the formation of the 3' single strand DNA overhang. Knocking down of Apollo can induce DNA damage response similar to that caused by the knocking down of TRF2. In this Letter, we report the design and synthesis of a class of cyclic peptidic mimetics of the TRFH binding motif of Apollo (Apollo TBM ). We found conformational control of the C terminal residues of Apollo TBM can effectively improve the binding affinity. We have obtained a crystal structure of a cyclic peptidic Apollo peptide mimetic ( 34 ) complexed with TRF2, which provides valuable guidance to the future design of TRF2 inhibitors.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ghassemi-Armaki, Hassan; Leff, Asher C.; Taheri, Mitra L.

Compression-compression cyclic deformation of nanocrystalline NiTi tubes intended for medical stents and with an outer diameter of 1 mm and wall thickness of 70 μm was studied using micropillars produced by FIB with the loading axis orthogonal to the tube axis. These micropillars were cycled in a displacement-controlled mode using a nanoindenter equipped with a flat punch to strain levels of 4, 6 and 8% in each cycle and specimens were subjected to several hundred cycles. Furthermore, the cyclic response of two NiTi tubes, one with Af of 17 °C and the other with an Af of -5 °C ismore » compared. The texture of the tube with the Af of -5 °C was measured at the microscopic level using transmission electron microscopy and at the macroscopic level by X-ray diffraction and good agreement was noted. Characteristics such as i) a reduction in the forward transformation stress, ii) increase in maximum stress for a given displacement amplitude, and iii) a reduction in the hysteresis loop area, all with increasing number of cycles, observed typically during cyclic deformation of conventional macroscopic specimens, were captured in the micropillar cyclic tests. Our observations lead to the conclusion that micropillar compression testing in a cyclic mode can enable characterizing the orientation-dependent response in such small dimension components that see complex loading in service, and additionally provide an opportunity for calibrating constitutive equations in micromechanical models.« less

Numerical Investigation of the Dynamic Properties of Intermittent Jointed Rock Models Subjected to Cyclic Uniaxial Compression

NASA Astrophysics Data System (ADS)

Liu, Yi; Dai, Feng; Zhao, Tao; Xu, Nu-wen

2017-01-01

Intermittent jointed rocks, which exist in a myriad of engineering projects, are extraordinarily susceptible to cyclic loadings. Understanding the dynamic fatigue properties of jointed rocks is necessary for evaluating the stability of rock engineering structures. This study numerically investigated the influences of cyclic loading conditions (i.e., frequency, maximum stress and amplitude) and joint geometric configurations (i.e., dip angle, persistency and interspace) on the dynamic fatigue mechanisms of jointed rock models. A reduction model of stiffness and strength was first proposed, and then, sixteen cyclic uniaxial loading tests with distinct loading parameters and joint geometries were simulated. Our results indicate that the reduction model can effectively reproduce the hysteresis loops and the accumulative plastic deformation of jointed rocks in the cyclic process. Both the loading parameters and the joint geometries significantly affect the dynamic properties, including the irreversible strain, damage evolution, dynamic residual strength and fatigue life. Three failure modes of jointed rocks, which are principally controlled by joint geometries, occur in the simulations: splitting failure through the entire rock sample, sliding failure along joint planes and mixed failure, which are principally controlled by joint geometries. Furthermore, the progressive failure processes of the jointed rock samples are numerically observed, and the different loading stages can be distinguished by the relationship between the number of broken bonds and the axial stress.

Rapidity evolution of Wilson lines at the next-to-leading order

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balitsky, Ian; Chirilli, Giovanni

2013-12-01

At high energies particles move very fast so the proper degrees of freedom for the fast gluons moving along the straight lines are Wilson-line operators - infinite gauge factors ordered along the line. In the framework of operator expansion in Wilson lines the energy dependence of the amplitudes is determined by the rapidity evolution of Wilson lines. We present the next-to-leading order hierarchy of the evolution equations for Wilson-line operators.

Biomechanical performance of different cable and wire cerclage configurations.

PubMed

Lenz, Mark; Perren, Stephan Marcel; Richards, Robert Geoff; Mückley, Thomas; Hofmann, Gunther Olaf; Gueorguiev, Boyko; Windolf, Markus

2013-01-01

Cerclage technology is regaining interest due to the increasing number of periprosthetic fractures. Different wiring techniques have been formerly proposed and have hibernated over years. Hereby, they are compared to current cerclage technology. Seven groups (n = 6) of different cable cerclage (Ø1.7 mm, crimp closure) configurations (one single cerclage looped once around the shells, one single cerclage looped twice, two cerclages each looped once) and solid wire cerclages (Ø1.5 mm, twist closure) (same configurations as cable cerclages, and two braided wires, twisted around each other looped once) fixed two cortical half shells of human femoral shaft mounted on a testing jig. Sinusoidal cyclic loading with constantly increasing force (0.1 N/cycle) was applied starting at 50 N peak load. Cerclage pretension (P), load leading to onset of plastic deformation (D) and load at total failure (T) were identified. Statistical differences between the groups were detected by univariate ANOVA. Double looped cables (P442N ± 129; D1334N ± 319; T2734N ± 330) performed significantly better (p < 0.05) than single looped cables (P292N ± 56; D646N ± 108; T1622N ± 171) and were comparable to two single cables (P392N ± 154; D1191N ± 334; T2675N ± 361). Double looped wires (P335N ± 49; D752N ± 119; T1359N ± 80) were significantly better (p < 0.05) than single looped wires (P181N ± 16; D343N ± 33; T606N ± 109) and performed similarly to single looped cables. Braided wires (P119N ± 26; D225N ± 55; T919N ± 197) exhibited early loss of pretension and plastic deformation. Double looped cerclages provided a better fixation stability compared to a single looped cerclage. Double looped wires were comparable to a single looped cable. The use of braided wires could not be recommended mechanically.

Nolan Wilson | NREL

Science.gov Websites

Nolan Wilson Nolan Wilson Postdoctoral Researcher-Chemical Engineering Nolan.Wilson@nrel.gov | 303 Ph.D., Chemical and Biomolecular Engineering, Clemson University, 2014 M.S., Chemical and Biomolecular Engineering, Clemson University, 2012 B.S., Chemical Engineering, Auburn University, 2007 Professional

Performance of a Water Recirculation Loop Maintenance Device and Process for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Rector, Tony; Steele, John W.; Bue, Grant C.; Campbell, Colin; Makinen, Janice

2012-01-01

A water loop maintenance device and process to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been undergoing a performance evaluation. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the water recirculation maintenance device and process is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance process further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware. This

Performance of Water Recirculation Loop Maintenance Components for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Rector, Tony; Peyton, Barbara M.; Steele, John W.; Makinen, Janice; Bue, Grant C.; Campbell, Colin

2014-01-01

Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a second SWME water recirculation loop with no water quality maintenance. Results show the benefits of periodic water maintenance. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the evaluation of water recirculation maintenance components was to further enhance this advantage through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A bed design that was developed for a UTAS military application, and considered for a potential ISS application with the Urine Processor Assembly, provided a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for ISS to introduce a biocide in a microgravity compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

Performance of Water Recirculation Loop Maintenance Components for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Rector, Tony; Peyton, Barbara M.; Steele, John W.; Makinen, Janice; Bue, Grant C.; Campbell, Colin

2014-01-01

Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a recirculating control loop which had no water quality maintenance. Results show that periodic water maintenance can improve performance of the SWME. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage of this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing sublimator technology. The driver for the evaluation of water recirculation maintenance components was to enhance the robustness of the SWME through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A patented bed design that was developed for a United Technologies Aerospace System military application provided a low pressure drop means for water maintenance in the SWME recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for the ISS to introduce a biocide in a microgravity compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

Performance of Water Recirculation Loop Maintentance Components for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Rector, Tony; Peyton, Barbara; Steele, John W.; Bue, Grant C.; Campbell, Colin; Makinen, Janice

2014-01-01

Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a second SWME water recirculation loop with no water quality maintenance. Results show the benefits of periodic water maintenance. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the evaluation of water recirculation maintenance components was to further enhance this advantage through the leveraging of fluid loop management lessonslearned from the International Space Station (ISS). A bed design that was developed for a UTAS military application, and considered for a potential ISS application with the Urine Processor Assembly, provided a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for ISS to introduce a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

A Ramanujan-type measure for the Askey-Wilson polynomials

NASA Technical Reports Server (NTRS)

Atakishiyev, Natig M.

1995-01-01

A Ramanujan-type representation for the Askey-Wilson q-beta integral, admitting the transformation q to q(exp -1), is obtained. Orthogonality of the Askey-Wilson polynomials with respect to a measure, entering into this representation, is proved. A simple way of evaluating the Askey-Wilson q-beta integral is also given.

75 FR 8749 - Dwayne LaFrantz Wilson, M.D.; Revocation of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Dwayne LaFrantz Wilson, M.D.; Revocation of... Enforcement Administration, issued an Order to Show Cause to Dwayne LaFrantz Wilson, M.D. (Respondent), of... Registration, BW6030857, issued to Dwayne LaFrantz Wilson, M.D., be, and it hereby is, revoked. I further order...

Interfacial Stresses and the Anomalous Character of Thermoelastic-Deformation Curves of a Cu-Al-Ni Shape-Memory Alloy

NASA Astrophysics Data System (ADS)

Malygin, G. A.; Nikolaev, V. I.; Pulnev, S. A.; Chikiryaka, A. V.

2017-12-01

Thermoelastic-deformation curves of a single-crystalline Cu-13.5 wt % Al-4.0 wt % Ni shapememory (SM) alloy have been studied. Cyclic temperature variation in a 300-450 K interval revealed an anomalous character of thermoelastic hysteresis loops with regions of accelerated straining at both heating and cooling stages. The observed phenomenon can be used for increasing the response speed of SM-alloy based drive and sensor devices. Analysis of this phenomenon in the framework of the theory of diffuse martensitic transformations showed that the anomalous character of thermoelastic hysteresis loops may be related to the influence of interfacial stresses on the dynamics of martensitic transformations in these SM alloys.

Attrition Rate of Oxygen Carriers in Chemical Looping Combustion Systems

NASA Astrophysics Data System (ADS)

Feilen, Harry Martin

This project developed an evaluation methodology for determining, accurately and rapidly, the attrition resistance of oxygen carrier materials used in chemical looping technologies. Existing test protocols, to evaluate attrition resistance of granular materials, are conducted under non-reactive and ambient temperature conditions. They do not accurately reflect the actual behavior under the unique process conditions of chemical looping, including high temperatures and cyclic operation between oxidizing and reducing atmospheres. This project developed a test method and equipment that represented a significant improvement over existing protocols. Experimental results obtained from this project have shown that hematite exhibits different modes of attrition, including both due to mechanical stresses and due to structural changes in the particles due to chemical reaction at high temperature. The test methodology has also proven effective in providing reactivity changes of the material with continued use, a property, which in addition to attrition, determines material life. Consumption/replacement cost due to attrition or loss of reactivity is a critical factor in the economic application of the chemical looping technology. This test method will allow rapid evaluation of a wide range of materials that are best suited for this technology. The most important anticipated public benefit of this project is the acceleration of the development of chemical looping technology for lowering greenhouse gas emissions from fossil fuel combustion.

SU (2) lattice gauge theory simulations on Fermi GPUs

NASA Astrophysics Data System (ADS)

Cardoso, Nuno; Bicudo, Pedro

2011-05-01

In this work we explore the performance of CUDA in quenched lattice SU (2) simulations. CUDA, NVIDIA Compute Unified Device Architecture, is a hardware and software architecture developed by NVIDIA for computing on the GPU. We present an analysis and performance comparison between the GPU and CPU in single and double precision. Analyses with multiple GPUs and two different architectures (G200 and Fermi architectures) are also presented. In order to obtain a high performance, the code must be optimized for the GPU architecture, i.e., an implementation that exploits the memory hierarchy of the CUDA programming model. We produce codes for the Monte Carlo generation of SU (2) lattice gauge configurations, for the mean plaquette, for the Polyakov Loop at finite T and for the Wilson loop. We also present results for the potential using many configurations (50,000) without smearing and almost 2000 configurations with APE smearing. With two Fermi GPUs we have achieved an excellent performance of 200× the speed over one CPU, in single precision, around 110 Gflops/s. We also find that, using the Fermi architecture, double precision computations for the static quark-antiquark potential are not much slower (less than 2× slower) than single precision computations.

Renormalization constants for 2-twist operators in twisted mass QCD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexandrou, C.; Computation-based Science and Technology Research Center, The Cyprus Institute, 15 Kypranoros Str., 1645 Nicosia; Constantinou, M.

2011-01-01

Perturbative and nonperturbative results on the renormalization constants of the fermion field and the twist-2 fermion bilinears are presented with emphasis on the nonperturbative evaluation of the one-derivative twist-2 vector and axial-vector operators. Nonperturbative results are obtained using the twisted mass Wilson fermion formulation employing two degenerate dynamical quarks and the tree-level Symanzik improved gluon action. The simulations have been performed for pion masses in the range of about 450-260 MeV and at three values of the lattice spacing a corresponding to {beta}=3.9, 4.05, 4.20. Subtraction of O(a{sup 2}) terms is carried out by performing the perturbative evaluation of thesemore » operators at 1-loop and up to O(a{sup 2}). The renormalization conditions are defined in the RI{sup '}-MOM scheme, for both perturbative and nonperturbative results. The renormalization factors, obtained for different values of the renormalization scale, are evolved perturbatively to a reference scale set by the inverse of the lattice spacing. In addition, they are translated to MS at 2 GeV using 3-loop perturbative results for the conversion factors.« less

Refined 3d-3d correspondence

NASA Astrophysics Data System (ADS)

Alday, Luis F.; Genolini, Pietro Benetti; Bullimore, Mathew; van Loon, Mark

2017-04-01

We explore aspects of the correspondence between Seifert 3-manifolds and 3d N = 2 supersymmetric theories with a distinguished abelian flavour symmetry. We give a prescription for computing the squashed three-sphere partition functions of such 3d N = 2 theories constructed from boundary conditions and interfaces in a 4d N = 2∗ theory, mirroring the construction of Seifert manifold invariants via Dehn surgery. This is extended to include links in the Seifert manifold by the insertion of supersymmetric Wilson-'t Hooft loops in the 4d N = 2∗ theory. In the presence of a mass parameter cfor the distinguished flavour symmetry, we recover aspects of refined Chern-Simons theory with complex gauge group, and in particular construct an analytic continuation of the S-matrix of refined Chern-Simons theory.

Bremsstrahlung function, leading Lüscher correction at weak coupling and localization

NASA Astrophysics Data System (ADS)

Bonini, Marisa; Griguolo, Luca; Preti, Michelangelo; Seminara, Domenico

2016-02-01

We discuss the near BPS expansion of the generalized cusp anomalous dimension with L units of R-charge. Integrability provides an exact solution, obtained by solving a general TBA equation in the appropriate limit: we propose here an alternative method based on supersymmetric localization. The basic idea is to relate the computation to the vacuum expectation value of certain 1/8 BPS Wilson loops with local operator insertions along the contour. These observables localize on a two-dimensional gauge theory on S 2, opening the possibility of exact calculations. As a test of our proposal, we reproduce the leading Lüscher correction at weak coupling to the generalized cusp anomalous dimension. This result is also checked against a genuine Feynman diagram approach in {N}=4 Super Yang-Mills theory.

August Wilson's Presentation of Interracial Movements in 1960s

ERIC Educational Resources Information Center

Li, Yanghua

2018-01-01

August Wilson's "Two Trains Running" tells the life predicaments of the patrons at Memphis' restaurant in the 1960s. Though Wilson avoids addressing the interracial conflicts and movements on stage to eschew protesting and propaganda, they as social background could not be totally ignored in the play. The paper analyses Wilson's use of…

Development of a cyclic voltammetry method for the detection of Clostridium novyi in black disease.

PubMed

Liu, L L; Jiang, D N; Xiang, G M; Liu, C; Yu, J C; Pu, X Y

2014-03-17

Black disease is an acute disease of sheep and cattle. The pathogen is the obligate anaerobe, Clostridium novyi. Due to difficulties of anaerobic culturing in the country or disaster sites, a simple, rapid, and sensitive method is required. In this study, an electrochemical method, the cyclic voltammetry method, basing on loop-mediated isothermal amplification (LAMP), electrochemical ion bonding (positive dye, methylene blue), was introduced. DNA extracted from C. novyi specimens was amplified through the LAMP reaction. Then the products combined were with methylene blue, which lead to a reduction in the oxidation peak current (ipA) and the reduction peak current (ipC) of the cyclic voltammetry. The changes of ipA/ipC were real-time measured by special designed electrode, so the DNA was quantitatively detected. The results displayed that this electrochemical detection of C. novyi could be completed in 1-2 h with the lowest bacterial concentration of 10(2) colony forming units/mL, and high accuracy (96.5%), sensitivity (96%), and specificity (97%) compared to polymerase chain reation. The cyclic voltammetry method was a simple and fast method, with high sensitivity and high specificity, and has great potential to be a usable molecular tool for fast diagnosis of Black disease.

Closed-loop supply chain models with considering the environmental impact.

PubMed

Mohajeri, Amir; Fallah, Mohammad

2014-01-01

Global warming and climate changes created by large scale emissions of greenhouse gases are a worldwide concern. Due to this, the issue of green supply chain management has received more attention in the last decade. In this study, a closed-loop logistic concept which serves the purposes of recycling, reuse, and recovery required in a green supply chain is applied to integrate the environmental issues into a traditional logistic system. Here, we formulate a comprehensive closed-loop model for the logistics planning considering profitability and ecological goals. In this way, we can achieve the ecological goal reducing the overall amount of CO2 emitted from journeys. Moreover, the profitability criterion can be supported in the cyclic network with the minimum costs and maximum service level. We apply three scenarios and develop problem formulations for each scenario corresponding to the specified regulations and investigate the effect of the regulation on the preferred transport mode and the emissions. To validate the models, some numerical experiments are worked out and a comparative analysis is investigated.

LUT observations of the mass-transferring binary AI Dra

NASA Astrophysics Data System (ADS)

Liao, Wenping; Qian, Shengbang; Li, Linjia; Zhou, Xiao; Zhao, Ergang; Liu, Nianping

2016-06-01

Complete UV band light curve of the eclipsing binary AI Dra was observed with the Lunar-based Ultraviolet Telescope (LUT) in October 2014. It is very useful to adopt this continuous and uninterrupted light curve to determine physical and orbital parameters of the binary system. Photometric solutions of the spot model are obtained by using the W-D (Wilson and Devinney) method. It is confirmed that AI Dra is a semi-detached binary with secondary component filling its critical Roche lobe, which indicates that a mass transfer from the secondary component to the primary one should happen. Orbital period analysis based on all available eclipse times suggests a secular period increase and two cyclic variations. The secular period increase was interpreted by mass transfer from the secondary component to the primary one at a rate of 4.12 ×10^{-8}M_{⊙}/yr, which is in agreement with the photometric solutions. Two cyclic oscillations were due to light travel-time effect (LTTE) via the presence of two cool stellar companions in a near 2:1 mean-motion resonance. Both photometric solutions and orbital period analysis confirm that AI Dra is a mass-transferring binary, the massive primary is filling 69 % of its critical Roche lobe. After the primary evolves to fill the critical Roche lobe, the mass transfer will be reversed and the binary will evolve into a contact configuration.

First photometric analysis of magnetic activity and orbital period variations for the semi-detached binary BU Vulpeculae

NASA Astrophysics Data System (ADS)

Wang, Jingjing; Zhang, Bin; Yu, Jing; Liu, Liang; Tian, Xiaoman

2018-06-01

Four sets of multi-color CCD photometric observations of the close binary BU Vul were carried out for four successive months in 2010. From our observations, there are obvious variations and asymmetry of light curves on the timescale of a month, indicating high-level stellar spot activity on the surface of at least one component. The Wilson-Devinney (2010) program was used to determine the photometric solutions, which suggest that BU Vul is a semi-detached binary with the cool, less massive component filling with the critical Roche lobe. The solutions also reveal that the spots on the primary and the secondary have changed and drifted in 2010 July, August, and September. Based on analysis of the O - C curves of BU Vul, its orbital period shows a cyclic oscillation (T3 = 22.4 yr, A3 = 0.0029 d) superimposed on a secular increase. The continuous increase is possibly a result of mass transfer from the less massive component to the more massive one at a rate of dM/dt = -2.95 × 10-9 M⊙ yr-1. The cyclic variation maybe be caused by the presence of a tertiary companion with extremely low luminosity. Combined with the distortions of the light curve on 2009 November 4, we infer that BU Vul has two additional companions in a quadruple system.

Wilson Disease

MedlinePlus

Wilson disease is a rare inherited disorder that prevents your body from getting rid of extra copper. You need ... copper into bile, a digestive fluid. With Wilson disease, the copper builds up in your liver, and ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandao, T.; Robinson, H; Johnson, S

Catalysis by the Yersinia protein-tyrosine phosphatase YopH is significantly impaired by the mutation of the conserved Trp354 residue to Phe. Though not a catalytic residue, this Trp is a hinge residue in a conserved flexible loop (the WPD-loop) that must close during catalysis. To learn why this seemingly conservative mutation reduces catalysis by 2 orders of magnitude, we have solved high-resolution crystal structures for the W354F YopH in the absence and in the presence of tungstate and vanadate. Oxyanion binding to the P-loop in W354F is analogous to that observed in the native enzyme. However, the WPD-loop in the presencemore » of oxyanions assumes a half-closed conformation, in contrast to the fully closed state observed in structures of the native enzyme. This observation provides an explanation for the impaired general acid catalysis observed in kinetic experiments with Trp mutants. A 1.4 Angstroms structure of the W354F mutant obtained in the presence of vanadate reveals an unusual divanadate species with a cyclic [VO]2 core, which has precedent in small molecules but has not been previously reported in a protein crystal structure.« less

Wilson Disease: Frequently Asked Questions

MedlinePlus

... Are Wilson's Wilson's Warriors WDA Publications Back Downloads Corporate Sponsorship Forms Membership Forms Resources The Big WOW ... Help Donate Become a Member The Big WOW Corporate Sponsorship Marketplace Contact Us Search Our Site About ...

ABOVE-THE-LOOP-TOP OSCILLATION AND QUASI-PERIODIC CORONAL WAVE GENERATION IN SOLAR FLARES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takasao, Shinsuke; Shibata, Kazunari, E-mail: takasao@kwasan.kyoto-u.ac.jp

Observations revealed that various kinds of oscillations are excited in solar flare regions. Quasi-periodic pulsations (QPPs) in flare emissions are commonly observed in a wide range of wavelengths. Recent observations have found that fast-mode magnetohydrodynamic (MHD) waves are quasi-periodically emitted from some flaring sites (quasi-periodic propagating fast-mode magnetoacoustic waves; QPFs). Both QPPs and QPFs imply a cyclic disturbance originating from the flaring sites. However, the physical mechanisms remain puzzling. By performing a set of two-dimensional MHD simulations of a solar flare, we discovered the local oscillation above the loops filled with evaporated plasma (above-the-loop-top region) and the generation of QPFsmore » from such oscillating regions. Unlike all previous models for QPFs, our model includes essential physics for solar flares such as magnetic reconnection, heat conduction, and chromospheric evaporation. We revealed that QPFs can be spontaneously excited by the above-the-loop-top oscillation. We found that this oscillation is controlled by the backflow of the reconnection outflow. The new model revealed that flare loops and the above-the-loop-top region are full of shocks and waves, which is different from the previous expectations based on a standard flare model and previous simulations. In this paper, we show the QPF generation process based on our new picture of flare loops and will briefly discuss a possible relationship between QPFs and QPPs. Our findings will change the current view of solar flares to a new view in which they are a very dynamic phenomenon full of shocks and waves.« less

Pathogenesis of Central and Complex Sleep Apnoea

PubMed Central

Orr, Jeremy E.; Malhotra, Atul; Sands, Scott A.

2016-01-01

Central sleep apnoea (CSA)—the temporary absence or diminution of ventilator effort during sleep—is seen in a variety of forms including periodic breathing in infancy and healthy adults at altitude and Cheyne-Stokes respiration in heart failure. In most circumstances, the cyclic absence of effort is paradoxically a consequence of hypersensitive ventilatory chemoreflex responses to oppose changes in airflow, i.e. elevated loop gain, leading to overshoot/undershoot ventilatory oscillations. Considerable evidence illustrates overlap between CSA and obstructive sleep apnoea (OSA), including elevated loop gain in patients with OSA and the presence of pharyngeal narrowing during central apnoeas. Indeed, treatment of OSA, whether via CPAP, tracheostomy, or oral appliances, can reveal CSA, an occurrence referred to as complex sleep apnoea. Factors influencing loop gain include increased chemosensitivity (increased controller gain), reduced damping of blood gas levels (increased plant gain) and increased lung to chemoreceptor circulatory delay. Sleep-wake transitions and pharyngeal dilator muscle responses effectively raise the controller gain and therefore also contribute to total loop gain and overall instability. In some circumstances, for example apnoea of infancy and central congenital hypoventilation syndrome, central apnoeas are the consequence of ventilatory depression and defective ventilatory responses, i.e. low loop gain. The efficacy of available treatments for CSA can be explained in terms of their effects on loop gain, e.g. CPAP improves lung volume (plant gain), stimulants reduce the alveolar-inspired PCO2 difference, supplemental oxygen lowers chemosensitivity. Understanding the magnitude of loop gain and the mechanisms contributing to instability may facilitate personalised interventions for CSA. PMID:27797160

Pathogenesis of central and complex sleep apnoea.

PubMed

Orr, Jeremy E; Malhotra, Atul; Sands, Scott A

2017-01-01

Central sleep apnoea (CSA) - the temporary absence or diminution of ventilatory effort during sleep - is seen in a variety of forms including periodic breathing in infancy and healthy adults at altitude and Cheyne-Stokes respiration in heart failure. In most circumstances, the cyclic absence of effort is paradoxically a consequence of hypersensitive ventilatory chemoreflex responses to oppose changes in airflow, that is elevated loop gain, leading to overshoot/undershoot ventilatory oscillations. Considerable evidence illustrates overlap between CSA and obstructive sleep apnoea (OSA), including elevated loop gain in patients with OSA and the presence of pharyngeal narrowing during central apnoeas. Indeed, treatment of OSA, whether via continuous positive airway pressure (CPAP), tracheostomy or oral appliances, can reveal CSA, an occurrence referred to as complex sleep apnoea. Factors influencing loop gain include increased chemosensitivity (increased controller gain), reduced damping of blood gas levels (increased plant gain) and increased lung to chemoreceptor circulatory delay. Sleep-wake transitions and pharyngeal dilator muscle responses effectively raise the controller gain and therefore also contribute to total loop gain and overall instability. In some circumstances, for example apnoea of infancy and central congenital hypoventilation syndrome, central apnoeas are the consequence of ventilatory depression and defective ventilatory responses, that is low loop gain. The efficacy of available treatments for CSA can be explained in terms of their effects on loop gain, for example CPAP improves lung volume (plant gain), stimulants reduce the alveolar-inspired PCO 2 difference and supplemental oxygen lowers chemosensitivity. Understanding the magnitude of loop gain and the mechanisms contributing to instability may facilitate personalized interventions for CSA. © 2016 Asian Pacific Society of Respirology.

NLO Hierarchy of Wilson Lines Evolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balitsky, Ian

2015-03-01

The high-energy behavior of QCD amplitudes can be described in terms of the rapidity evolution of Wilson lines. I present the hierarchy of evolution equations for Wilson lines in the next-to-leading order.

1. VIEW EAST, LOOKING TOWARDS BRIDGE FROM WILSON SHUTE ROAD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW EAST, LOOKING TOWARDS BRIDGE FROM WILSON SHUTE ROAD (STATE ROAD 2008) - Wilson Shute Bridge, Spanning French Creek at State Road 2008 (formerly Legislative Route 20027), Meadville, Crawford County, PA

War, Medicine, and Cultural Diplomacy in the Americas: Frank Wilson and Brazilian cardiology.

PubMed

Kropf, Simone P; Howell, Joel D

2017-10-01

American cultural diplomacy played a key role in the institutionalization of Brazilian cardiology. In 1942, Frank Wilson, an internationally recognized pioneer in electrocardiography, made an extended wartime visit to Rio de Janeiro and São Paulo. The visit was sponsored by the United States Department of State as part of Roosevelt's Good Neighbor Policy and brought Wilson together with a group of physicians who would establish the specialty of cardiology in Brazil. This US cultural and diplomatic initiative strengthened an academic network that was already evolving and would eventually prove to be of benefit to both sides. Latin American physicians began in the 1920s to visit Wilson's laboratory at the University of Michigan, where they established the relationships on which Wilson would build. While affiliation with the "Wilson school" advanced the cause of Brazilian cardiologists who sought to establish themselves as specialists, cooperation with Latin American physicians benefitted Wilson in his pursuit of wider recognition for his innovations in the use of electrocardiography (ECG). Wilson's identity as a scientific ambassador to Latin America helped in legitimating his approach to the clinical application of the ECG. A close examination of Wilson's relationship to Brazilian cardiology demonstrates the role played by science and medicine as a part of wartime cultural diplomacy, as well as the dynamics of the transnational circulation of scientific knowledge and practices. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Investigation of using wavelet analysis for classifying pattern of cyclic voltammetry signals

NASA Astrophysics Data System (ADS)

Jityen, Arthit; Juagwon, Teerasak; Jaisuthi, Rawat; Osotchan, Tanakorn

2017-09-01

Wavelet analysis is an excellent technique for data processing analysis based on linear vector algebra since it has an ability to perform local analysis and is able to analyze an unspecific localized area of a large signal. In this work, the wavelet analysis of cyclic waveform was investigated in order to find the distinguishable feature from the cyclic data. The analyzed wavelet coefficients were proposed to be used as selected cyclic feature parameters. The cyclic voltammogram (CV) of different electrodes consisting of carbon nanotube (CNT) and several types of metal phthalocyanine (MPc) including CoPc, FePc, ZnPc and MnPc powders was used as several sets of cyclic data for various types of coffee. The mixture powder was embedded in a hollow Teflon rod and used as working electrodes. Electrochemical response of the fabricated electrodes in Robusta, blend coffee I, blend coffee II, chocolate malt and cocoa at the same concentrations was measured with scanning rate of 0.05V/s from -1.5 to 1.5V respectively to Ag/AgCl electrode for five scanning loops. The CV of blended CNT electrode with some MPc electrodes indicated the ionic interaction which can be the effect of catalytic oxidation of saccharides and/or polyphenol on the sensor surface. The major information of CV response can be extracted by using several mother wavelet families viz. daubechies (dB1 to dB3), coiflets (coiflet1), biorthogonal (Bior1.1) and symlets (sym2) and then the discrimination of these wavelet coefficients of each data group can be separated by principal component analysis (PCA). The PCA results indicated the clearly separate groups with total contribution more than 62.37% representing from PC1 and PC2.

Performance of a Water Recirculation Loop Maintenance Device and Process for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

2013-01-01

A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The bed design further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

Design and Evaluation of a Water Recirculation Loop Maintenance Device for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

2012-01-01

A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high-capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit Transport Water Loop. The bed design further leverages a sorbent developed for the ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System. The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of crewed spaceflight Environmental Control and Life Support System hardware.

Design and Evaluation of a Water Recirculation Loop Maintenance Device for the Advanced Spacesuit Water Membrane Evaporator

NASA Technical Reports Server (NTRS)

Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

2011-01-01

A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The bed design further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a clear demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

Effect of liver transplantation on brain magnetic resonance imaging pathology in Wilson disease: a case report.

PubMed

Litwin, T; Dzieżyc, K; Poniatowska, R; Członkowska, A

2013-01-01

The authors present a case report of a 28-year-old patient with hepatic, but no neurological, signs of Wilson disease, with pathological changes in both the globi pallidi and caudate found with routine brain magnetic resonance imaging (MRI). The patient was recommended for liver transplantation by hepatologists, and during the two years of observation after liver transplantation, MRI brain abnormalities due to Wilson disease completely regressed. On the basis of this case, the authors present an argument for the prognostic significance of brain MRI in Wilson disease as well as current recommendations concerning liver transplantation in Wilson disease.

Neuromuscular Electrical Stimulation Therapy for Dysphagia Caused by Wilson's Disease

PubMed Central

Lee, Seon Yeong; Yang, Hee Seung; Lee, Seung Hwa; Jeung, Hae Won; Park, Young Ok

2012-01-01

Wilson's disease is an autosomal recessive disorder of abnormal copper metabolism. Although dysphagia is a common complaint of patients with Wilson's disease and pneumonia is an important cause of death in these patients, management of swallowing function has rarely been reported in the context of Wilson's disease. Hence, we report a case of Wilson's disease presenting with dysphagia. A 33-year-old man visited our hospital with a complaint of difficulty in swallowing, since about last 7 years and which had worsened since the last 2-3 months. He was diagnosed with Wilson's disease about 13 years ago. On the initial VFSS, reduced hyoid bone movement, impaired epiglottic movement and moderate amount of residue in the valleculae during the pharyngeal phase were noted. After 10 sessions of neuromuscular electrical stimulation for 1 hour per day, decreased amount of residue was observed in the valleculae during the pharyngeal phase on the follow-up VFSS. PMID:22837979

Wilsonian methods of concept analysis: a critique.

PubMed

Hupcey, J E; Morse, J M; Lenz, E R; Tasón, M C

1996-01-01

Wilsonian methods of concept analysis--that is, the method proposed by Wilson and Wilson-derived methods in nursing (as described by Walker and Avant; Chinn and Kramer [Jacobs]; Schwartz-Barcott and Kim; and Rodgers)--are discussed and compared in this article. The evolution and modifications of Wilson's method in nursing are described and research that has used these methods, assessed. The transformation of Wilson's method is traced as each author has adopted his techniques and attempted to modify the method to correct for limitations. We suggest that these adaptations and modifications ultimately erode Wilson's method. Further, the Wilson-derived methods have been overly simplified and used by nurse researchers in a prescriptive manner, and the results often do not serve the purpose of expanding nursing knowledge. We conclude that, considering the significance of concept development for the nursing profession, the development of new methods and a means for evaluating conceptual inquiry must be given priority.

Matrix pentagons

NASA Astrophysics Data System (ADS)

Belitsky, A. V.

2017-10-01

The Operator Product Expansion for null polygonal Wilson loop in planar maximally supersymmetric Yang-Mills theory runs systematically in terms of multi-particle pentagon transitions which encode the physics of excitations propagating on the color flux tube ending on the sides of the four-dimensional contour. Their dynamics was unraveled in the past several years and culminated in a complete description of pentagons as an exact function of the 't Hooft coupling. In this paper we provide a solution for the last building block in this program, the SU(4) matrix structure arising from internal symmetry indices of scalars and fermions. This is achieved by a recursive solution of the Mirror and Watson equations obeyed by the so-called singlet pentagons and fixing the form of the twisted component in their tensor decomposition. The non-singlet, or charged, pentagons are deduced from these by a limiting procedure.

Regge meets collinear in strongly-coupled N=4 super Yang-Mills

NASA Astrophysics Data System (ADS)

Sprenger, Martin

2017-01-01

We revisit the calculation of the six-gluon remainder function in planar N=4 super Yang-Mills theory from the strong coupling TBA in the multi-Regge limit and identify an infinite set of kinematically subleading terms. These new terms can be compared to the strong coupling limit of the finite-coupling expressions for the impact factor and the BFKL eigenvalue proposed by Basso et al. in [1], which were obtained from an analytic continuation of the Wilson loop OPE. After comparing the results order by order in those subleading terms, we show that it is possible to precisely map both formalisms onto each other. A similar calculation can be carried out for the seven-gluon amplitude, the result of which shows that the central emission vertex does not become trivial at strong coupling.

FACILITY 859, DETAIL OF SOUTHWEST SIDE (WILSON STREET SIDE), SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

FACILITY 859, DETAIL OF SOUTHWEST SIDE (WILSON STREET SIDE), SHOWING CHEVRON DESIGN OVER FORMER PASSAGEWAY, VIEW FACING NORTHEAST. - Schofield Barracks Military Reservation, Quadrangle K Barracks Type, Between Wilson Street & Capron Avenue near Williston Avenue, Wahiawa, Honolulu County, HI

The failure mode of two reabsorbable fixation systems: Swivelock with Fibertape versus Bio-Corkscrew with Fiberwire in bovine rotator cuff.

PubMed

De Carli, Angelo; Lanzetti, Riccardo Maria; Monaco, Edoardo; Labianca, Luca; Mossa, Luigi; Ferretti, Andrea; Feretti, Andrea

2012-11-01

Despite technical advances in rotator cuff surgery, recurrent or persistent defects in the repaired tendon continue to occur. The improved strength of sutures and suture anchors has shown that the most common site of failure is the suture-tendon interface. The purpose of this study was to compare two different types of repair under both cyclic and load-to-failure conditions. The hypothesis is that the use of a fixation system with knotless anchor and taped suture results in better biomechanical performance, under both cyclic and load-to-failure conditions. Thirty bovine shoulder specimens were randomly assigned to two group tests: the Swivelock 5-mm anchor with Fibertape (Group A) and the Bio-Corkscrew 5 mm with Fiberwire (Group B). We simulated the reconstruction of a rotator cuff tear with a single-row technique, performing a tenodesis with types A and B fixation. Each specimen underwent cyclic testing from 5 to 30 N for 30 cycles, followed by load-to-failure testing, in order to calculate the ultimate failure load (UFL). Load-to-failure tests revealed a significantly higher UFL in Group A than in Group B. Wire fixing failed at the anchor loop whereas tape fixing failed at the sutures, suture-tendon interface, and anchors. Cyclic testing revealed no significantly greater slippage between the two groups. Stiffness values were not statistically significantly different. In all cases, tendons remained intact until the end of the cyclic testing. The tape structure is biomechanically stronger than the wire structure.

Hepatocellular Carcinoma: An Unusual Complication of Longstanding Wilson Disease.

PubMed

Gunjan, Deepak; Shalimar; Nadda, Neeti; Kedia, Saurabh; Nayak, Baibaswata; Paul, Shashi B; Gamanagatti, Shivanand Ramachandra; Acharya, Subrat K

2017-06-01

Wilson disease is caused by the accumulation of copper in the liver, brain or other organs, due to the mutation in ATP7B gene, which encodes protein that helps in excretion of copper in the bile canaliculus. Clinical presentation varies from asymptomatic elevation of transaminases to cirrhosis with decompensation. Hepatocellular carcinoma is a known complication of cirrhosis, but a rare occurrence in Wilson disease. We present a case of neurological Wilson disease, who later developed decompensated cirrhosis and hepatocellular carcinoma.

Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

NASA Astrophysics Data System (ADS)

Brashear, R.

2004-12-01

The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

SU (2) lattice gauge theory simulations on Fermi GPUs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardoso, Nuno, E-mail: nunocardoso@cftp.ist.utl.p; Bicudo, Pedro, E-mail: bicudo@ist.utl.p

2011-05-10

In this work we explore the performance of CUDA in quenched lattice SU (2) simulations. CUDA, NVIDIA Compute Unified Device Architecture, is a hardware and software architecture developed by NVIDIA for computing on the GPU. We present an analysis and performance comparison between the GPU and CPU in single and double precision. Analyses with multiple GPUs and two different architectures (G200 and Fermi architectures) are also presented. In order to obtain a high performance, the code must be optimized for the GPU architecture, i.e., an implementation that exploits the memory hierarchy of the CUDA programming model. We produce codes formore » the Monte Carlo generation of SU (2) lattice gauge configurations, for the mean plaquette, for the Polyakov Loop at finite T and for the Wilson loop. We also present results for the potential using many configurations (50,000) without smearing and almost 2000 configurations with APE smearing. With two Fermi GPUs we have achieved an excellent performance of 200x the speed over one CPU, in single precision, around 110 Gflops/s. We also find that, using the Fermi architecture, double precision computations for the static quark-antiquark potential are not much slower (less than 2x slower) than single precision computations.« less

Full-scale 3-D finite element modeling of a two-loop pressurized water reactor for heat transfer, thermal–mechanical cyclic stress analysis, and environmental fatigue life estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, Subhasish; Soppet, William K.; Majumdar, Saurindranath

This paper discusses a system-level finite element model of a two-loop pressurized water reactor (PWR). Based on this model, system-level heat transfer analysis and subsequent sequentially coupled thermal-mechanical stress analysis were performed for typical thermal-mechanical fatigue cycles. The in-air fatigue lives of example components, such as the hot and cold legs, were estimated on the basis of stress analysis results, ASME in-air fatigue life estimation criteria, and fatigue design curves. Furthermore, environmental correction factors and associated PWR environment fatigue lives for the hot and cold legs were estimated by using estimated stress and strain histories and the approach described inmore » US-NRC report: NUREG-6909.« less

Small gold nanoparticles presenting linear and looped Cilengitide analogues as radiosensitizers of cells expressing ανβ3 integrin

NASA Astrophysics Data System (ADS)

Travis, Adam R.; Liau, Virginia A.; Agrawal, Amanda C.; Cliffel, David E.

2017-11-01

This work uses linear and looped RGDfV sequences attached to the surface of small (1.8 nm in diameter) gold nanoparticles (AuNPs) to enhance the radiosensitizating effects of Cilengitide, a cyclic RGDf ( NMe)V pentapeptide that targets αvβ3 integrin which is overexpressed in certain cancers. Following synthesis and purification, the AuNPs were evaluated in vitro against HUVEC, H460, and MCF7 cells in clonogenic assays using a 137Cs irradiator. Untargeted AuNPs induced no significant dose enhancement factors (DEFs) in any of the cell types when compared to radiation treatment alone, whereas all evaluated AuNPs functionalized with targeting peptides performed at least as well as controls (irradiation after Cilengitide treatment). The observed DEFs also suggest that cyclizing the linear peptides into more spatially constrained, looped structures may facilitate target binding. These greater dose enhancements merit future in vivo studies of drug-AuNP conjugates to assess the ability of the nanostructures to provide an improved therapeutic benefit over treatment with drug candidates and radiation alone. [Figure not available: see fulltext.

Closed-Loop Supply Chain Models with Considering the Environmental Impact

PubMed Central

Fallah, Mohammad

2014-01-01

Global warming and climate changes created by large scale emissions of greenhouse gases are a worldwide concern. Due to this, the issue of green supply chain management has received more attention in the last decade. In this study, a closed-loop logistic concept which serves the purposes of recycling, reuse, and recovery required in a green supply chain is applied to integrate the environmental issues into a traditional logistic system. Here, we formulate a comprehensive closed-loop model for the logistics planning considering profitability and ecological goals. In this way, we can achieve the ecological goal reducing the overall amount of CO2 emitted from journeys. Moreover, the profitability criterion can be supported in the cyclic network with the minimum costs and maximum service level. We apply three scenarios and develop problem formulations for each scenario corresponding to the specified regulations and investigate the effect of the regulation on the preferred transport mode and the emissions. To validate the models, some numerical experiments are worked out and a comparative analysis is investigated. PMID:25309960

Superelastic SMA U-shaped dampers with self-centering functions

NASA Astrophysics Data System (ADS)

Wang, Bin; Zhu, Songye

2018-05-01

As high-performance metallic materials, shape memory alloys (SMAs) have been investigated increasingly by the earthquake engineering community in recent years, because of their remarkable self-centering (SC) and energy-dissipating capabilities. This paper systematically presents an experimental study on a novel superelastic SMA U-shaped damper (SMA-UD) with SC function under cyclic loading. The mechanical properties, including strength, SC ability, and energy-dissipating capability with varying loading amplitudes and strain rates are evaluated. Test results show that excellent and stable flag-shaped hysteresis loops are exhibited in multiple loading cycles. Strain rate has a negligible effect on the cyclic behavior of the SMA-UD within the dynamic frequency range of typical interest in earthquake engineering. Furthermore, a numerical investigation is performed to understand the mechanical behavior of the SMA-UD. The numerical model is calibrated against the experimental results with reasonable accuracy. Then, the stress–strain states with different phase transformations are also discussed.

DEEP, LOW-MASS RATIO OVERCONTACT BINARY SYSTEMS. XII. CK BOOTIS WITH POSSIBLE CYCLIC MAGNETIC ACTIVITY AND ADDITIONAL COMPANION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Y.-G.; Qian, S.-B.; Soonthornthum, B., E-mail: yygcn@163.com, E-mail: qsb@ynao.ac.cn

2012-05-15

We present precision CCD photometry, a period study, and a two-color simultaneous Wilson code solution of the short-period contact binary CK Bootis. The asymmetric light curves were modeled by a dark spot on the primary component. The result identifies that CK Boo is an A-type W UMa binary with a high fillout of f = 71.7({+-} 4.4)%. From the O - C curve, it is found that the orbital period changes in a complicated mode, i.e., a long-term increase with two sinusoidal variations. One cyclic oscillation with a period of 10.67({+-} 0.20) yr may result from magnetic activity cycles, whichmore » are identified by the variability of Max. I - Max. II. Another sinusoidal variation (i.e., A = 0.0131 days({+-} 0.0009 days) and P{sub 3} = 24.16({+-} 0.64) yr) may be attributed to the light-time effect due to a third body. This kind of additional companion can extract angular momentum from the central binary system. The orbital period secularly increases at a rate of dP/dt = +9.79 ({+-}0.80) Multiplication-Sign 10{sup -8} days yr{sup -1}, which may be interpreted by conservative mass transfer from the secondary to the primary. This kind of deep, low-mass ratio overcontact binaries may evolve into a rapid-rotating single star, only if the contact configuration do not break down at J{sub spin} > (1/3)J{sub orb}.« less

Life prediction of thermomechanical fatigue using total strain version of strainrange partitioning (SRP): A proposal

NASA Technical Reports Server (NTRS)

Saltsman, James F.; Halford, Gary R.

1988-01-01

A method is proposed (without experimental verification) for extending the total strain version of Strainrange Partitioning (TS-SRP) to predict the lives of thermomechanical fatigue (TMF) cycles. The principal feature of TS SRP is the determination of the time-temperature-waveshape dependent elastic strainrange versus life lines that are added subsequently to the classical inelastic strainrange versus life lines to form the total strainrange versus life relations. The procedure is based on a derived relation between failure and flow behavior. Failure behavior is represented by conventional SRP inelastic strainrange versus cyclic life relations, while flow behavior is captured in terms of the cyclic stress-strain response characteristics. Stress-strain response is calculated from simple equations developed from approximations to more complex cyclic constitutive models. For applications to TMF life prediction, a new testing technique, bithermal cycling, is proposed as a means for generating the inelastic strainrange versus life relations. Flow relations for use in predicting TMF lives would normally be obtained from approximations to complex thermomechanical constitutive models. Bithermal flow testing is also proposed as an alternative to thermomechanical flow testing at low strainranges where the hysteresis loop is difficult to analyze.

Gradient-type modeling of the effects of plastic recovery and surface passivation in thin films

NASA Astrophysics Data System (ADS)

Liu, Jinxing; Kah Soh, Ai

2016-08-01

The elasto-plastic responses of thin films subjected to cyclic tension-compression loading and bending are studied, with a focus on Bauschinger and size effects. For this purpose, a model is established by incorporating plastic recovery into the strain gradient plasticity theory we proposed recently. Elastic and plastic parts of strain and strain gradient, which are determined by the elasto-plastic decomposition according to the associative rule, are assumed to have a degree of material-dependent reversibility. Based on the above assumption, a dislocation reversibility-dependent rule is built to describe evolutions of different deformation components under cyclic loadings. Furthermore, a simple strategy is provided to implement the passivated boundary effects by introducing a gradual change to relevant material parameters in the yield function. Based on this theory, both bulge and bending tests under cyclic loading conditions are investigated. By comparing the present predictions with the existing experimental data, it is found that the yield function is able to exhibit the size effect, the Bauschinger effect, the influence of surface passivation and the hysteresis-loop phenomenon. Thus, the proposed model is deemed helpful in studying plastic deformations of micron-scale films.

Density-dependent mass gain by Wilson's Warblers during stopover

Treesearch

Jeffrey F. Kelly; Linda S. DeLay; Deborah M. Finch

2002-01-01

The need restore energetic reserves at stopover sites constrains avian migration ecology. To describe that constraint, we examined relationships among mass gained by Wilson's Warblers (Wilsonia pusilla) during stopover, abundance of Wilson's Warblers (i.e. capture rate), and arthropod abundance during autumn migration. We found that amount...

Drama Queen

ERIC Educational Resources Information Center

Carpenter, Angelica Shirley

2006-01-01

This article presents an interview with Jacqueline Wilson, a popular British author of children's books. Wilson has published 86 books for children and young adults with more than 20 million copies sold in the U.K. alone. Wilson's fans--mostly seven- to 14-year-old girls--love her gripping plots about dysfunctional families, homelessness, and…

Beyond the scope of Free-Wilson analysis: building interpretable QSAR models with machine learning algorithms.

PubMed

Chen, Hongming; Carlsson, Lars; Eriksson, Mats; Varkonyi, Peter; Norinder, Ulf; Nilsson, Ingemar

2013-06-24

A novel methodology was developed to build Free-Wilson like local QSAR models by combining R-group signatures and the SVM algorithm. Unlike Free-Wilson analysis this method is able to make predictions for compounds with R-groups not present in a training set. Eleven public data sets were chosen as test cases for comparing the performance of our new method with several other traditional modeling strategies, including Free-Wilson analysis. Our results show that the R-group signature SVM models achieve better prediction accuracy compared with Free-Wilson analysis in general. Moreover, the predictions of R-group signature models are also comparable to the models using ECFP6 fingerprints and signatures for the whole compound. Most importantly, R-group contributions to the SVM model can be obtained by calculating the gradient for R-group signatures. For most of the studied data sets, a significant correlation with that of a corresponding Free-Wilson analysis is shown. These results suggest that the R-group contribution can be used to interpret bioactivity data and highlight that the R-group signature based SVM modeling method is as interpretable as Free-Wilson analysis. Hence the signature SVM model can be a useful modeling tool for any drug discovery project.

Samuel Alexander Kinnier Wilson. Wilson's disease, Queen Square and neurology.

PubMed

Broussolle, E; Trocello, J-M; Woimant, F; Lachaux, A; Quinn, N

2013-12-01

This historical article describes the life and work of the British physician Samuel Alexander Kinnier Wilson (1878-1937), who was one of the world's greatest neurologists of the first half of the 20th century. Early in his career, Wilson spent one year in Paris in 1903 where he learned from Pierre-Marie at Bicêtre Hospital. He subsequently retained uninterrupted links with French neurology. He also visited in Leipzig the German anatomist Paul Flechsig. In 1904, Wilson returned to London, where he worked for the rest of his life at the National Hospital for the Paralysed and Epileptic (later the National Hospital for Nervous Diseases, and today the National Hospital for Neurology and Neurosurgery) in Queen Square, and also at Kings' College Hospital. He wrote on 'the old motor system and the new', on disorders of motility and muscle tone, on the epilepsies, on aphasia, apraxia, tics, and pathologic laughing and crying, and most importantly on Wilson's disease. The other objective of our paper is to commemorate the centenary of Wilson's most important work published in 1912 in Brain, and also in Revue Neurologique, on an illness newly recognized and characterized by him entitled "Progressive lenticular degeneration, a familial nervous disease associated with liver cirrhosis". He analyzed 12 clinical cases, four of whom he followed himself, but also four cases previously published by others and a further two that he considered in retrospect had the same disease as he was describing. The pathological profile combined necrotic damage in the lenticular nuclei of the brain and hepatic cirrhosis. This major original work is summarized and discussed in the present paper. Wilson not only delineated what was later called hepato-lenticular degeneration and Wilson's disease, but also introduced for the first time the terms extrapyramidal syndrome and extrapyramidal system, stressing the role of the basal ganglia in motility. The present historical work emphasizes the special contributions made by Wilson to the study of movement disorders, including akinesia and bradykinesia in Parkinson's disease, and their relation to basal ganglia pathology. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Traveltime, reaeration, and water-quality characteristics during low-flow conditions in Wilsons Creek and the James River near Springfield, Missouri

USGS Publications Warehouse

Berkas, W.R.

1987-01-01

Before upgrading the Southwest Wastewater-Treatment Plant near Springfield, Missouri, to tertiary treatment, adverse water quality conditions resulting from discharge of wastewater effluent to Wilson Creek were documented in the creek and in the James River. About 7 years after the upgrading of the treatment plant, traveltime, reaeration, and water quality characteristics were determined in Wilsons Creek and the James River. Traveltime was measured once in Wilsons Creek and twice in the James River during low-flow conditions. Traveltimes in the James River were estimated for discharge between 55 and 200 cu ft/sec at a site near Boaz. Reaeration coefficients were calculated for five reaches in Wilsons Creek and the James River using the modified-tracer technique. Calculated reaeration coefficients were compared with coefficients predicted by twelve empirical equations and one equation was chosen that best fit the data. Water quality data were collected during two 44-hr periods, August 14 to 16, 1984, and July 23 to 25, 1985. Samples were collected at the outflow of the Southwest Wastewater Treatment Plant at seven sites along Wilsons Creek and the James River. Dissolved-oxygen concentrations in Wilsons Creek and the James River were all larger than Missouri 's water quality standard of 5.0 mg/l. Ammonia concentrations and 5-day carbonaceous biochemical oxygen demands were small, which indicated that the oxygen consumption by oxidizing ammonia and carbonaceous organic materials would be insignificant. Measured streambed oxygen demand in the James River was largest directly downstream from Wilsons Creek. (USGS)

Human Sociobiology: Wilson's Fallacy.

ERIC Educational Resources Information Center

Lehrman, Nathaniel S.

1981-01-01

Presents an introduction to and a critique of E.O. Wilson's new science of sociobiology, which focuses on explaining the social behavior of species as diverse as ants, apes, and humans. Suggests that Wilson has gone beyond his data in claiming that complex human behaviors such as altruism are caused to any extent by genetic, as opposed to…

The Modern First Lady and Public Policy: From Edith Wilson through Hillary Rodham Clinton.

ERIC Educational Resources Information Center

Black, Allida M.

2001-01-01

Discusses the role in and influence on public policy of twentieth century First Ladies including Edith Roosevelt, Helen Taft, Ellen Wilson, Edith Wilson, Florence Harding, Lou Henry Hoover, Eleanor Roosevelt, Jacqueline Kennedy, Lady Bird Johnson, Rosalynn Carter, Nancy Reagan, Barbara Bush, and Hillary Rodham Clinton. (CMK)

Effects of urban runoff and wastewater effluent on Wilsons Creek and James River near Springfield, Missouri

USGS Publications Warehouse

Berkas, Wayne R.

1980-01-01

Statistical analysis on water-quality parameters from James River upstream and downstream from the confluence of Wilsons Creek shows a significant difference for all parameters except temperature and dissolved silica at the 0.05 probability level. Regression analysis shows correlation for discharge with dissolved sodium, dissolved chloride, and dissolved potassium, and for specific conductance with dissolved chloride and dissolved sulfate at the station downstream from Wilsons Creek. This is due to the consistent quality of the effluent from the Southwest Wastewater Plant on Wilsons Creek. Water-quality monitor stations upstream and downstream from the wastewater plant indicate that the plant has a degrading effect on dissolved oxygen in Wilsons Creek and James River. The monitors also indicate that rainfall flushes momentarily poor quality water into Wilsons Creek from the urbanized Springfield area. Overall, the runoff is diluting the effluent from the wastewater plant. Rainfall and runoff stations indicate a rapid response of runoff to rainfall due to the high percentage of imperviousness and the filling or paving of sinkholes. (USGS)

Patient support groups in the management of Wilson disease.

PubMed

Graper, Mary L; Schilsky, Michael L

2017-01-01

Patient support groups serve an important function for those affected by a disease but especially for people with a rare disease. Because of the complexity of Wilson disease there are some unique and difficult problems faced by groups that advocate for these patients. We give a comparative overview of the differences between groups that support people with more common diseases and groups that serve the rare disease population. The history and current status of the Wilson Disease Association and other worldwide Wilson disease groups are described and information about other organizations that support Wilson disease in additional ways is explained. The specific challenges faced in the support of Wilson disease patients are outlined and possible solutions proposed. Drawing from experience in speaking with many patients, we discuss some of the most common questions that are asked by patients who are seeking a possible diagnosis or are already on treatment. There are many options for improving patient advocacy efforts in the future that we hope will be accomplished. © 2017 Elsevier B.V. All rights reserved.

Quantitative evaluation of first-order retardation corrections to the quarkonium spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brambilla, N.; Prosperi, G.M.

1992-08-01

We evaluate numerically first-order retardation corrections for some charmonium and bottomonium masses under the usual assumption of a Bethe-Salpeter purely scalar confinement kernel. The result depends strictly on the use of an additional effective potential to express the corrections (rather than to resort to Kato perturbation theory) and on an appropriate regularization prescription. The kernel has been chosen in order to reproduce in the instantaneous approximation a semirelativistic potential suggested by the Wilson loop method. The calculations are performed for two sets of parameters determined by fits in potential theory. The corrections turn out to be typically of the ordermore » of a few hundred MeV and depend on an additional scale parameter introduced in the regularization. A conjecture existing in the literature on the origin of the constant term in the potential is also discussed.« less

Towards a bootstrap approach to higher orders of epsilon expansion

NASA Astrophysics Data System (ADS)

Dey, Parijat; Kaviraj, Apratim

2018-02-01

We employ a hybrid approach in determining the anomalous dimension and OPE coefficient of higher spin operators in the Wilson-Fisher theory. First we do a large spin analysis for CFT data where we use results obtained from the usual and the Mellin bootstrap and also from Feynman diagram literature. This gives new predictions at O( ɛ 4) and O( ɛ 5) for anomalous dimensions and OPE coefficients, and also provides a cross-check for the results from Mellin bootstrap. These higher orders get contributions from all higher spin operators in the crossed channel. We also use the bootstrap in Mellin space method for ϕ 3 in d = 6 - ɛ CFT where we calculate general higher spin OPE data. We demonstrate a higher loop order calculation in this approach by summing over contributions from higher spin operators of the crossed channel in the same spirit as before.

Experimental and theoretical study of topology and electronic correlations in PuB4

NASA Astrophysics Data System (ADS)

Choi, Hongchul; Zhu, Wei; Cary, S. K.; Winter, L. E.; Huang, Zhoushen; McDonald, R. D.; Mocko, V.; Scott, B. L.; Tobash, P. H.; Thompson, J. D.; Kozimor, S. A.; Bauer, E. D.; Zhu, Jian-Xin; Ronning, F.

2018-05-01

We synthesize single crystals of PuB4 using an Al-flux technique. Single-crystal diffraction data provide structural parameters for first-principles density functional theory (DFT) calculations. By computing the density of states, the Z2 topological invariant using the Wilson loop method, and the surface electronic structure from slab calculations, we find that PuB4 is a nonmagnetic strong topological insulator with a band gap of 254 meV. Our magnetic susceptibility, heat capacity, and resistivity measurements are consistent with this analysis, albeit with a smaller gap of 35 meV. DFT plus dynamical mean-field theory calculations show that electronic correlations reduce the size of the band gap, and provide better agreement with the value determined by resistivity. These results demonstrate that PuB4 is a promising actinide material to investigate the interplay of electronic correlations and nontrivial topology.

Topological Quantum Phase Transition in Synthetic Non-Abelian Gauge Potential: Gauge Invariance and Experimental Detections

PubMed Central

Sun, Fadi; Yu, Xiao-Lu; Ye, Jinwu; Fan, Heng; Liu, Wu-Ming

2013-01-01

The method of synthetic gauge potentials opens up a new avenue for our understanding and discovering novel quantum states of matter. We investigate the topological quantum phase transition of Fermi gases trapped in a honeycomb lattice in the presence of a synthetic non-Abelian gauge potential. We develop a systematic fermionic effective field theory to describe a topological quantum phase transition tuned by the non-Abelian gauge potential and explore its various important experimental consequences. Numerical calculations on lattice scales are performed to compare with the results achieved by the fermionic effective field theory. Several possible experimental detection methods of topological quantum phase transition are proposed. In contrast to condensed matter experiments where only gauge invariant quantities can be measured, both gauge invariant and non-gauge invariant quantities can be measured by experimentally generating various non-Abelian gauges corresponding to the same set of Wilson loops. PMID:23846153

The study of Thai stock market across the 2008 financial crisis

NASA Astrophysics Data System (ADS)

Kanjamapornkul, K.; Pinčák, Richard; Bartoš, Erik

2016-11-01

The cohomology theory for financial market can allow us to deform Kolmogorov space of time series data over time period with the explicit definition of eight market states in grand unified theory. The anti-de Sitter space induced from a coupling behavior field among traders in case of a financial market crash acts like gravitational field in financial market spacetime. Under this hybrid mathematical superstructure, we redefine a behavior matrix by using Pauli matrix and modified Wilson loop for time series data. We use it to detect the 2008 financial market crash by using a degree of cohomology group of sphere over tensor field in correlation matrix over all possible dominated stocks underlying Thai SET50 Index Futures. The empirical analysis of financial tensor network was performed with the help of empirical mode decomposition and intrinsic time scale decomposition of correlation matrix and the calculation of closeness centrality of planar graph.

Toward {U}(N|M) knot invariant from ABJM theory

NASA Astrophysics Data System (ADS)

Eynard, Bertrand; Kimura, Taro

2017-06-01

We study {U}(N|M) character expectation value with the supermatrix Chern-Simons theory, known as the ABJM matrix model, with emphasis on its connection to the knot invariant. This average just gives the half-BPS circular Wilson loop expectation value in ABJM theory, which shall correspond to the unknot invariant. We derive the determinantal formula, which gives {U}(N|M) character expectation values in terms of {U}(1|1) averages for a particular type of character representations. This means that the {U}(1|1) character expectation value is a building block for the {U}(N|M) averages and also, by an appropriate limit, for the {U}(N) invariants. In addition to the original model, we introduce another supermatrix model obtained through the symplectic transform, which is motivated by the torus knot Chern-Simons matrix model. We obtain the Rosso-Jones-type formula and the spectral curve for this case.

Hypopituitarism Presenting as Adrenal Insufficiency and Hypothyroidism in a Patient with Wilson's Disease: a Case Report

PubMed Central

2016-01-01

Wilson's disease typically presents symptoms associated with liver damage or neuropsychiatric disturbances, while endocrinologic abnormalities are rare. We report an unprecedented case of hypopituitarism in a patient with Wilson's disease. A 40-year-old woman presented with depression, general weakness and anorexia. Laboratory tests and imaging studies were compatible with liver cirrhosis due to Wilson's disease. Basal hormone levels and pituitary function tests indicated secondary hypothyroidism and adrenal insufficiency due to hypopituitarism. Brain MRI showed T2 hyperintense signals in both basal ganglia and midbrain but the pituitary imaging was normal. She is currently receiving chelation therapy along with thyroid hormone and steroid replacement. There may be a relationship between Wilson's disease and hypopituitarism. Copper deposition or secondary neuronal damage in the pituitary may be a possible explanation for this theory. PMID:27478349

Hypopituitarism Presenting as Adrenal Insufficiency and Hypothyroidism in a Patient with Wilson's Disease: a Case Report.

PubMed

Lee, Hae Won; Kang, Jin Du; Yeo, Chang Woo; Yoon, Sung Woon; Lee, Kwang Jae; Choi, Mun Ki

2016-08-01

Wilson's disease typically presents symptoms associated with liver damage or neuropsychiatric disturbances, while endocrinologic abnormalities are rare. We report an unprecedented case of hypopituitarism in a patient with Wilson's disease. A 40-year-old woman presented with depression, general weakness and anorexia. Laboratory tests and imaging studies were compatible with liver cirrhosis due to Wilson's disease. Basal hormone levels and pituitary function tests indicated secondary hypothyroidism and adrenal insufficiency due to hypopituitarism. Brain MRI showed T2 hyperintense signals in both basal ganglia and midbrain but the pituitary imaging was normal. She is currently receiving chelation therapy along with thyroid hormone and steroid replacement. There may be a relationship between Wilson's disease and hypopituitarism. Copper deposition or secondary neuronal damage in the pituitary may be a possible explanation for this theory.

A Screening Test for Wilson's Disease and its Application to Psychiatric Patients

PubMed Central

Cox, Diane Wilson

1967-01-01

Varied modes of onset make the early diagnosis of Wilson's disease difficult. A deficiency of serum ceruloplasmin, usually characteristic of the disease, was used as the basis for a screening test. Simple test materials and provision for handling about 50 plasma samples simultaneously made this test feasible for large-scale screening. The screening test was applied to 336 persons hospitalized for psychiatric disorders, to detect patients with Wilson's disease before the classical symptoms appeared. Two patients with ceruloplasmin levels below the normal limits were detected but did not have Wilson's disease. Further application of the screening test to relatives of patients known to have Wilson's disease and to individuals with any symptoms of the disease (hepatic disease, extrapyramidal dysfunction, psychiatric disorders, behaviour problems in children) would aid in early diagnosis and more effective treatment. ImagesFig. 1 PMID:6017170

Cognitive Abilities of Children With Neurological and Liver Forms of Wilson Disease.

PubMed

Favre, Emilie; Lion-François, Laurence; Canton, Marie; Vanlemmens, Claire; Bonneton, Marjorie; Bouillet, Lise; Brunet, Anne-Sophie; Lachaux, Alain

2017-03-01

Cognitive impairment in adult patients experiencing Wilson disease is now more clearly described, even in liver forms of the disease. Although this condition can appear during childhood, the cognitive abilities of children have not yet been reported in a substantial case series. This retrospective study included 21 children with Wilson disease who had undergone general cognitive assessment. The results argue in favor of a poor working memory capacity in the liver form of the disease, and more extensive cognitive impairments in its neurological form. Extensive neuropsychological investigations on all children experiencing Wilson disease are thus required.

Sensitivity of polycrystal plasticity to slip system kinematic hardening laws for Al 7075-T6

DOE PAGES

Hennessey, Conor; Castelluccio, Gustavo M.; McDowell, David L.

2017-02-01

The prediction of formation and early growth of microstructurally small fatigue cracks requires use of constitutive models that accurately estimate local states of stress, strain, and cyclic plastic strain. However, few research efforts have attempted to systematically consider the sensitivity of overall cyclic stress-strain hysteresis and higher order mean stress relaxation and plastic strain ratcheting responses introduced by the slip system back-stress formulation in crystal plasticity, even for face centered cubic (FCC) crystal systems. This paper explores the performance of two slip system level kinematic hardening models using a finite element crystal plasticity implementation as a User Material Subroutine (UMAT)more » within ABAQUS, with fully implicit numerical integration. The two kinematic hardening formulations aim to reproduce the cyclic deformation of polycrystalline Al 7075-T6 in terms of both macroscopic cyclic stress-strain hysteresis loop shape, as well as ratcheting and mean stress relaxation under strain- or stress-controlled loading with mean strain or stress, respectively. The first formulation is an Armstrong-Frederick type hardening-dynamic recovery law for evolution of the back stress. This approach is capable of reproducing observed deformation under completely reversed uniaxial loading conditions, but overpredicts the rate of cyclic ratcheting and associated mean stress relaxation. The second formulation corresponds to a multiple back stress Ohno-Wang type hardening law with nonlinear dynamic recovery. The adoption of this back stress evolution law greatly improves the capability to model experimental results for polycrystalline specimens subjected to cycling with mean stress or strain. As a result, the relation of such nonlinear dynamic recovery effects are related to slip system interactions with dislocation substructures.« less

Sensitivity of polycrystal plasticity to slip system kinematic hardening laws for Al 7075-T6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hennessey, Conor; Castelluccio, Gustavo M.; McDowell, David L.

The prediction of formation and early growth of microstructurally small fatigue cracks requires use of constitutive models that accurately estimate local states of stress, strain, and cyclic plastic strain. However, few research efforts have attempted to systematically consider the sensitivity of overall cyclic stress-strain hysteresis and higher order mean stress relaxation and plastic strain ratcheting responses introduced by the slip system back-stress formulation in crystal plasticity, even for face centered cubic (FCC) crystal systems. This paper explores the performance of two slip system level kinematic hardening models using a finite element crystal plasticity implementation as a User Material Subroutine (UMAT)more » within ABAQUS, with fully implicit numerical integration. The two kinematic hardening formulations aim to reproduce the cyclic deformation of polycrystalline Al 7075-T6 in terms of both macroscopic cyclic stress-strain hysteresis loop shape, as well as ratcheting and mean stress relaxation under strain- or stress-controlled loading with mean strain or stress, respectively. The first formulation is an Armstrong-Frederick type hardening-dynamic recovery law for evolution of the back stress. This approach is capable of reproducing observed deformation under completely reversed uniaxial loading conditions, but overpredicts the rate of cyclic ratcheting and associated mean stress relaxation. The second formulation corresponds to a multiple back stress Ohno-Wang type hardening law with nonlinear dynamic recovery. The adoption of this back stress evolution law greatly improves the capability to model experimental results for polycrystalline specimens subjected to cycling with mean stress or strain. As a result, the relation of such nonlinear dynamic recovery effects are related to slip system interactions with dislocation substructures.« less

Sizable electron/neutron electric dipole moment in D 3 /D 7 μ -split supersymmetry

NASA Astrophysics Data System (ADS)

Dhuria, Mansi; Misra, Aalok

2014-10-01

Within the framework of N =1 gauged supergravity, using a phenomenological model that can be obtained locally as a Swiss-cheese Calabi-Yau string-theoretic compactification with a mobile D 3 -brane localized on a nearly special Lagrangian three cycle in the Calabi-Yau and fluxed stacks of wrapped D 7 -branes, and which provides a natural realization of μ -split supersymmetry (SUSY), we show that in addition to getting a significant value of an [electron/neutron (e/n)] electron dipole moment (EDM) at two-loop level, one can obtain a sizable contribution of (e/n) EDM even at one-loop level due to the presence of heavy supersymmetric fermions nearly isospectral with heavy sfermions. Unlike traditional split SUSY models in which the one-loop diagrams do not give significant contribution to the EDM of the electron/neutron because of very heavy sfermions existing as propagators in the loop, we show that one obtains a "healthy" value of the EDM in our model because of the presence of a heavy Higgsino, neutralino/chargino, and gaugino as fermionic propagators in the loops. The independent C P -violating phases are generated from nontrivial distinct phase factors associated with four Wilson line moduli [identified with first-generation leptons and quarks and their S U (2 )L -singlet cousins] as well as the D 3 -brane position moduli (identified with two Higgses), and the same are sufficient to produce overall distinct phase factors corresponding to all possible effective Yukawas as well as effective gauge couplings that we discuss in the context of N =1 gauged supergravity action. However, the complex phases responsible to generate a nonzero EDM at one-loop level mainly appear from an off-diagonal contribution of sfermion as well as Higgs mass matrices at the electroweak scale (EW). In our analysis, we obtain a dominant contribution of the electron/neutron EDM around de/e ≡O (1 0-29) cm from two-loop diagrams involving heavy sfermions and a light Higgs, and de/e ≡O (1 0-32) cm from a one-loop diagram involving a heavy chargino and a light Higgs as propagators in the loop. The neutron EDM gets a dominant contribution of the order dn/e ≡O (1 0-33) cm from the one-loop diagram involving SM-like quarks and Higgs. To justify the possibility of obtaining a large EDM value in the case of a Barr-Zee diagram which involves W± and the Higgs (responsible to generate the nontrivial C P -violating phase) in the two-loop diagrams as discussed by Leigh et al. [Nucl. Phys. B267, 509 (1986)], we provide an analysis of the same in the context of our D 3 /D 7 μ -split SUSY model at the EW scale. By conjecturing that the C P -violating phase can appear from the diagonalization of the Higgs mass matrix obtained in the context of μ -split SUSY, we also get an EDM of the electron/neutron around O (1 0-27) e cm in the case of the two-loop diagram involving W± bosons.

78 FR 51735 - Notice of FY 2013 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... Refugee Social Services formula awards to States and Wilson/Fish Alternative Project grantees. The FY 2013 formula allocations for Social Services are available on ORR's Web site at: http://www.acf.hhs.gov...] Notice of FY 2013 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative Project...

What to Teach about Asia: Howard Wilson and the Committee on Asiatic Studies in the 1940s

ERIC Educational Resources Information Center

Shaffer, Robert

2001-01-01

In 1942, Howard Wilson, a professor at the Harvard Graduate School of Education and the editor of the Harvard Educational Review, called for the "easternization of America," in reaction to what he called the "glib" talk for years about the "westernization of Asia." Funded by the Rockefeller Foundation, Wilson's…

Morbus Wilson: Case report of a two-year-old child as first manifestation.

PubMed

Beyersdorff, Anke; Findeisen, Annette

2006-04-01

Morbus Wilson, or Wilson's disease, is a genetic disease of copper metabolism. Usually the disease is detected when the first clinical symptoms appear, generally not before 5 years of age. This case report shows that the disease can be detected much earlier if abnormal laboratory findings in the patient's history prompt further investigations.

Wilson-Racah quantum system

NASA Astrophysics Data System (ADS)

Alhaidari, A. D.; Taiwo, T. J.

2017-02-01

Using a recent formulation of quantum mechanics without a potential function, we present a four-parameter system associated with the Wilson and Racah polynomials. The continuum scattering states are written in terms of the Wilson polynomials whose asymptotics give the scattering amplitude and phase shift. On the other hand, the finite number of discrete bound states are associated with the Racah polynomials.

33 CFR 110.218 - Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. 110.218 Section 110.218 Navigation and Navigable Waters COAST... Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. (a) The anchorage grounds...

33 CFR 110.218 - Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. 110.218 Section 110.218 Navigation and Navigable Waters COAST... Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. (a) The anchorage grounds...

33 CFR 110.218 - Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. 110.218 Section 110.218 Navigation and Navigable Waters COAST... Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. (a) The anchorage grounds...

33 CFR 110.218 - Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. 110.218 Section 110.218 Navigation and Navigable Waters COAST... Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. (a) The anchorage grounds...

Unfair Treatment vs. Confirmation Bias? Comments on Santelices and Wilson. Research Report. ETS RR-10-20

ERIC Educational Resources Information Center

Dorans, Neil J.

2010-01-01

Santelices and Wilson (2010) claimed to have addressed technical criticisms of Freedle (2003) presented in Dorans (2004a) and elsewhere. Santelices and Wilson's abstract claimed that their study confirmed that SAT[R] verbal items do function differently for African American and White subgroups. In this commentary, I demonstrate that the…

Woodrow Wilson: Prophet of Peace. Teaching with Historic Places.

ERIC Educational Resources Information Center

Goehner, Thomas B.

This lesson describes President Woodrow Wilson's struggle with and his ultimate failure at achieving lasting world peace through the League of Nations. The lesson focuses on November 23, 1923, the eve of the fifth anniversary of the Armistice that concluded World War I, when a frail and ill Wilson was ready to deliver a commemorative address by…

33 CFR 110.218 - Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. 110.218 Section 110.218 Navigation and Navigable Waters COAST... Pacific Ocean at San Clemente Island, Calif.; in vicinity of Wilson Cove. (a) The anchorage grounds...

In-Plane Behaviour of a Reinforcement Concrete Frame with a Dry Stack Masonry Panel

PubMed Central

Lin, Kun; Totoev, Yuri Zarevich; Liu, Hongjun; Guo, Tianyou

2016-01-01

In order to improve the energy dissipation of the masonry infilled frame structure while decreasing the stiffening and strengthening effects of the infill panels, a new dry stacked panel (DSP) semi-interlocking masonry (SIM) infill panel has been developed. In this paper, the material properties of DSP and a traditional unreinforced masonry (URM) panel have been evaluated experimentally. A series of cyclic tests were performed to investigate the cyclic behaviour of the reinforcement concrete (RC) frame with different infill panels. The failure modes, damage evolution, hysteretic behaviour, stiffness degradation and energy dissipation were compared and analysed. We concluded that DSP is capable of significantly improving the seismic energy dissipation due to its hysteretic behaviour when the frame is in elastic stage without increasing the stiffness of the frame. Therefore, DSP or SIM panels can be considered as frictional dampers. Based on the experimental results, the influence of DSP was examined. Using the parallel model, the hysteretic loops of DSP subjected to different load cases were achieved. The typical full hysteretic loop for DSP could be divided into three distinct stages of behaviour: packing stage, constant friction stage and equivalent strut stage. The connection between the panel and the frame had a great effect on the transferring of different mechanical stages. The constant friction stage was verified to provide substantial energy dissipation and benefits to the ductility of the structure, which, therefore, is suggested to be prolonged in reality. PMID:28787906

In-Plane Behaviour of a Reinforcement Concrete Frame with a Dry Stack Masonry Panel.

PubMed

Lin, Kun; Totoev, Yuri Zarevich; Liu, Hongjun; Guo, Tianyou

2016-02-11

In order to improve the energy dissipation of the masonry infilled frame structure while decreasing the stiffening and strengthening effects of the infill panels, a new dry stacked panel (DSP) semi-interlocking masonry (SIM) infill panel has been developed. In this paper, the material properties of DSP and a traditional unreinforced masonry (URM) panel have been evaluated experimentally. A series of cyclic tests were performed to investigate the cyclic behaviour of the reinforcement concrete (RC) frame with different infill panels. The failure modes, damage evolution, hysteretic behaviour, stiffness degradation and energy dissipation were compared and analysed. We concluded that DSP is capable of significantly improving the seismic energy dissipation due to its hysteretic behaviour when the frame is in elastic stage without increasing the stiffness of the frame. Therefore, DSP or SIM panels can be considered as frictional dampers. Based on the experimental results, the influence of DSP was examined. Using the parallel model, the hysteretic loops of DSP subjected to different load cases were achieved. The typical full hysteretic loop for DSP could be divided into three distinct stages of behaviour: packing stage, constant friction stage and equivalent strut stage. The connection between the panel and the frame had a great effect on the transferring of different mechanical stages. The constant friction stage was verified to provide substantial energy dissipation and benefits to the ductility of the structure, which, therefore, is suggested to be prolonged in reality.

RtcB is the RNA ligase component of an Escherichia coli RNA repair operon.

PubMed

Tanaka, Naoko; Shuman, Stewart

2011-03-11

RNA 2',3'-cyclic phosphate ends play important roles in RNA metabolism as substrates for RNA ligases during tRNA restriction-repair and tRNA splicing. Diverse bacteria from multiple phyla encode a two-component RNA repair cassette, comprising Pnkp (polynucleotide kinase-phosphatase-ligase) and Hen1 (RNA 3'-terminal ribose 2'-O-methyltransferase), that heals and then seals broken tRNAs with 2',3'-cyclic phosphate and 5'-OH ends. The Pnkp-Hen1 repair operon is absent in the majority of bacterial species, thereby raising the prospect that other RNA repair systems might be extant. A candidate component is RNA 3'-phosphate cyclase, a widely distributed enzyme that transforms RNA 3'-monophosphate termini into 2',3'-cyclic phosphates but cannot seal the ends it produces. Escherichia coli RNA cyclase (RtcA) is encoded in a σ(54)-regulated operon with RtcB, a protein of unknown function. Taking a cue from Pnkp-Hen1, we purified E. coli RtcB and tested it for RNA ligase activity. We report that RtcB per se seals broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester. We speculate that: (i) RtcB might afford bacteria a means to recover from stress-induced RNA damage; and (ii) RtcB homologs might catalyze tRNA repair or splicing reactions in archaea and eukarya.

Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies*

PubMed Central

Kesavardhana, Sannula; Das, Raksha; Citron, Michael; Datta, Rohini; Ecto, Linda; Srilatha, Nonavinakere Seetharam; DiStefano, Daniel; Swoyer, Ryan; Joyce, Joseph G.; Dutta, Somnath; LaBranche, Celia C.; Montefiori, David C.; Flynn, Jessica A.; Varadarajan, Raghavan

2017-01-01

A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly neutralizing antibody (bNAb) responses. The trimeric envelope glycoprotein (Env) spikes on HIV-1 are known to contain multiple epitopes that are susceptible to bNAbs isolated from infected individuals. Nonetheless, all trimeric and monomeric Env immunogens designed to date have failed to elicit such antibodies. We report the structure-guided design of HIV-1 cyclically permuted gp120 that forms homogeneous, stable trimers, and displays enhanced binding to multiple bNAbs, including VRC01, VRC03, VRC-PG04, PGT128, and the quaternary epitope-specific bNAbs PGT145 and PGDM1400. Constructs that were cyclically permuted in the V1 loop region and contained an N-terminal trimerization domain to stabilize V1V2-mediated quaternary interactions, showed the highest homogeneity and the best antigenic characteristics. In guinea pigs, a DNA prime-protein boost regimen with these new gp120 trimer immunogens elicited potent neutralizing antibody responses against highly sensitive Tier 1A isolates and weaker neutralizing antibody responses with an average titer of about 115 against a panel of heterologous Tier 2 isolates. A modest fraction of the Tier 2 virus neutralizing activity appeared to target the CD4 binding site on gp120. These results suggest that cyclically permuted HIV-1 gp120 trimers represent a viable platform in which further modifications may be made to eventually achieve protective bNAb responses. PMID:27879316

How Hugh Hampton Young's treatment of President Woodrow Wilson's urinary retention and urosepsis affected the resolution of World War I.

PubMed

Fogg, Ryan; Kutikov, Alexander; Uzzo, Robert G; Canter, Daniel

2011-09-01

President Woodrow Wilson was never able to gain ratification of the Treaty of Versailles, the peace accord to end World War I. Before he could convince the American people of the importance of ratification, Wilson suffered a stroke followed by life threatening urinary sepsis due to urinary retention, and was treated by the father of modern urology, Hugh Hampton Young. The effects of these health problems are examined in the context of their implications on international affairs. Biographical sources and primary documentation of Wilson's physicians were reviewed to determine the effect of Wilson's stroke on his voiding habits. Hugh Hampton Young's evaluation and decision making is examined in depth. In the fall of 1919 President Wilson was recovering from a stroke. Shortly after the stroke his preexisting voiding dysfunction progressed to urinary retention from which urinary sepsis developed. Hugh Hampton Young advised on Wilson's case and counseled patience over surgery. The President began voiding spontaneously and recovered from sepsis. The illness left him severely weakened and unable to mount an aggressive campaign to persuade the U.S. Senate of the importance of ratifying the Treaty of Versailles. His personal physician, Admiral Cary T. Grayson, stated that the President was mentally never the same after the sepsis. Wilson's voiding dysfunction contributed to his inability to win approval for the Treaty of Versailles and the League of Nations. As a result, the United States returned to a policy of isolationism and Europe plunged into 2 decades of upheaval, leading to World War II. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Woodrow Wilson's hidden stroke of 1919: the impact of patient-physician confidentiality on United States foreign policy.

PubMed

Menger, Richard P; Storey, Christopher M; Guthikonda, Bharat; Missios, Symeon; Nanda, Anil; Cooper, John M

2015-07-01

World War I catapulted the United States from traditional isolationism to international involvement in a major European conflict. Woodrow Wilson envisaged a permanent American imprint on democracy in world affairs through participation in the League of Nations. Amid these defining events, Wilson suffered a major ischemic stroke on October 2, 1919, which left him incapacitated. What was probably his fourth and most devastating stroke was diagnosed and treated by his friend and personal physician, Admiral Cary Grayson. Grayson, who had tremendous personal and professional loyalty to Wilson, kept the severity of the stroke hidden from Congress, the American people, and even the president himself. During a cabinet briefing, Grayson formally refused to sign a document of disability and was reluctant to address the subject of presidential succession. Wilson was essentially incapacitated and hemiplegic, yet he remained an active president and all messages were relayed directly through his wife, Edith. Patient-physician confidentiality superseded national security amid the backdrop of friendship and political power on the eve of a pivotal juncture in the history of American foreign policy. It was in part because of the absence of Woodrow Wilson's vocal and unwavering support that the United States did not join the League of Nations and distanced itself from the international stage. The League of Nations would later prove powerless without American support and was unable to thwart the rise and advance of Adolf Hitler. Only after World War II did the United States assume its global leadership role and realize Wilson's visionary, yet contentious, groundwork for a Pax Americana. The authors describe Woodrow Wilson's stroke, the historical implications of his health decline, and its impact on United States foreign policy.

Breeding habitat use by sympatric and allopatric populations of Wilson's Warblers and Yellow Warblers

USGS Publications Warehouse

Ruth, J.M.; Stanley, T.R.

2002-01-01

We studied Wilson's Warbler (Wilsonia pusilla) and Yellow Warbler (Dendroica petechia) habitat use in allopatric and sympatric populations in the Rocky Mountains of northern Colorado and southeastern Wyoming in order to better understand the different habitat needs and interactions of these two species. Foraging Wilson's Warblers and Yellow Warblers used very similar habitat, both selecting larger, more open shrubs. In spite of similar foraging habitat, comparisons of habitat use by the two species at the sympatric sites yielded no evidence of foraging habitat partitioning or exclusion. There was evidence of nesting habitat partitioning. Wilson's Warblers nested on the ground, with some evidence that they used smaller, more densely stemmed shrubs under which to nest. Yellow Warblers are shrub nesters and selected larger, more open shrubs in which to nest. Results provide no evidence that Yellow Warblers can be blamed for population declines in Wilson's Warblers.

Late onset of Wilson's disease in a family with genetic haemochromatosis.

PubMed

Dib, Nina; Valsesia, Emmanuelle; Malinge, Marie Claire; Mauras, Yves; Misrahi, Micheline; Calès, Paul

2006-01-01

We report the coexistence of Wilson's disease and genetic haemochromatosis in one family. The diagnosis of genetic haemochromatosis was established in a 52-year-old man. Among his siblings, one 57-year-old sister and one 55-year-old brother had decreased copper and ceruloplasmin levels in serum and increased urinary copper excretion. The sister shared the same human leucocyte antigen haplotypes and was homozygous for the HFE mutation C282Y, like the propositus. However, she had normal liver iron content and increased liver copper content. Her dietary copper intake was probably excessive. The association of Wilson's disease and genetic haemochromatosis is rare and has only been described twice. The onset of Wilson's disease after 50 years of age is rare; Wilson's disease should be considered in any patient with unexplained chronic liver disease; an excess in liver copper content might be induced by excessive dietary input in a susceptible individual.

Seismic performance of recycled concrete-filled square steel tube columns

NASA Astrophysics Data System (ADS)

Chen, Zongping; Jing, Chenggui; Xu, Jinjun; Zhang, Xianggang

2017-01-01

An experimental study on the seismic performance of recycled concrete-filled square steel tube (RCFST) columns is carried out. Six specimens were designed and tested under constant axial compression and cyclic lateral loading. Two parameters, replacement percentage of recycled coarse aggregate (RCA) and axial compression level, were considered in the test. Based on the experimental data, the hysteretic loops, skeleton curves, ductility, energy dissipation capacity and stiffness degradation of RCFST columns were analyzed. The test results indicate that the failure modes of RCFST columns are the local buckling of the steel tube at the bottom of the columns, and the hysteretic loops are full and their shapes are similar to normal CFST columns. Furthermore, the ductility coefficient of all specimens are close to 3.0, and the equivalent viscous damping coefficient corresponding to the ultimate lateral load ranges from 0.323 to 0.360, which demonstrates that RCFST columns exhibit remarkable seismic performance.

77 FR 52752 - Notice of FY 2012 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... allocations for Social Services are available on ORR's Web site at: http://www.acf.hhs.gov/programs/orr/policy...] Notice of FY 2012 Refugee Social Services Formula Awards to States and Wilson/Fish Alternative Project... allocation of Refugee Social Services formula awards to States and Wilson/Fish Alternative Project grantees...

Precision in the Teaching, Learning, and Communication of Elementary School Mathematics: A Reply to Wilson's "Elementary School Mathematics Priorities"

ERIC Educational Resources Information Center

Maher, Carolyn; Weber, Keith

2009-01-01

In "Elementary School Mathematics Priorities," Wilson (2009 [this issue]) presents a list of five core concepts that students should master in elementary school so that they can succeed in algebra. As researchers in mathematics education, the authors enthusiastically endorse Wilson's recommendations. Learning algebra is key to further study of…

Fermilab Tours

Science.gov Websites

is limited. Check the calendar for dates and registration. Visitors meet in the Wilson Hall atrium and making your way to the 1st floor of Wilson Hall in time for the tour. Fermilab is a busy lab so Fermilab's exhibit and viewing areas on the 15th floor of Wilson Hall are open Monday-Friday from 8 a.m. to 4

Polynitrogen Chemistry, Synthesis, Characterization, and Crystal Structure of Surprisingly Stable Fluoroantimonate Salts of N5(+)

DTIC Science & Technology

2001-03-01

Ber. 1966, 99, 1589. (6) Pankratov , V. A.; Savenkova, N. I. Zhur. Neorg. Khim. 1968, 13, 2610. (7) Christe, K. 0.; Wilson, R. D.; Sawodny, W, J. Mol...Structure 1971, 8, 245. Christe, K. 0.; Wilson, R. D.; Wilson, W. W.; Bau, R.; Sukumar, S.; Dixon, D. A. J. Am. Chem. Soc. 1991 , 113, 1991 . (8

Weak hamiltonian Wilson Coefficients from Lattice QCD

NASA Astrophysics Data System (ADS)

Bruno, Mattia

2018-03-01

n this work we present a calculation of the Wilson Coefficients C1 and C2 of the Effective Weak Hamiltonian to all-orders in αs, using lattice simulations. Given the current availability of lattice spacings we restrict our calculation to unphysically light W bosons around 2 GeV and we study the systematic uncertainties of the two Wilson Coefficients.

78 FR 68073 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... member of a family control group consisting of James T. Wilson, Jr., Sarah Wilson, James Terill Wilson... FEDERAL RESERVE SYSTEM Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company The notificants listed below have applied under the Change in Bank Control Act (12 U.S.C...

The Impact of Literacy Intervention on Academic Performance of Third Grade At-Risk Students

ERIC Educational Resources Information Center

Williams, Vernita

2015-01-01

Third grade at-risk students in Wilson County Schools, Wilson, NC continuously perform below the state average on the North Carolina Third Grade Reading End-of-Grade test. Leaders in the Wilson County Schools school district implemented a literacy pull-out intervention program for third grade at-risk students as a strategy to improve reading…

Sunspots: Wilson Effect

NASA Astrophysics Data System (ADS)

Maltby, P.; Murdin, P.

2000-11-01

The Wilson effect refers to the depressed appearance of SUNSPOTS when positioned close to the solar limb. The impression is that sunspots are cavities in the SOLAR PHOTOSPHERE. The reason is that the radiation we observe is coming from deeper layers in the sunspot than in the surrounding photosphere. The detection of this depression by Alexander Wilson dates back to 1769. The phenomenon is exp...

"Mens Sana in Corpore Sano": Human Values in Thomas Wilson's "The Arte of Rhetorique."

ERIC Educational Resources Information Center

Luehring, Janet

In 1553 the work that is touted as the first complete book written in English on rhetoric was published, Thomas Wilson's "Arte of Rhetorique." It became so popular it enjoyed eight printings within its century. Wilson was not a person to translate and read just for knowledge; he believed that knowledge should be imparted to the general…

The Cultural Origins and Play Philosophy of Playworkers: An Interview with Penny Wilson

ERIC Educational Resources Information Center

American Journal of Play, 2009

2009-01-01

Penny Wilson is a playworker--one of a group of professionals who facilitate children's play in adventure playgrounds, parks, and other settings, principally in the United Kingdom. Wilson grew up in the Southeast of England and spent much of her childhood playing on the coast near her family home. She studied illustration in art school, settled in…

The principles of teratology: are they still true?

PubMed

Friedman, Jan M

2010-10-01

James Wilson originally proposed a set of "Principles of Teratology" in 1959, the year before he helped to found the Teratology Society. By 1977, when these Principles were presented in a more definitive form in Wilson and Fraser's Handbook of Teratology, they had become a standard formulation of the basic tenets of the field. Wilson's Principles have continued to guide scientific research in teratology, and they are widely used in teaching. Recent advances in our knowledge of the molecular and cellular bases of embryogenesis serve only to provide a deeper understanding of the fundamental developmental mechanisms that underlie Wilson's Principles of Teratology. © 2010 Wiley-Liss, Inc.

Pressure, temperature, and electric field dependence of phase transformations in niobium modified 95/5 lead zirconate titanate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, Wen D.; Carlos Valadez, J.; Gallagher, John A.

2015-06-28

Ceramic niobium modified 95/5 lead zirconate-lead titanate (PZT) undergoes a pressure induced ferroelectric to antiferroelectric phase transformation accompanied by an elimination of polarization and a volume reduction. Electric field and temperature drive the reverse transformation from the antiferroelectric to ferroelectric phase. The phase transformation was monitored under pressure, temperature, and electric field loading. Pressures and temperatures were varied in discrete steps from 0 MPa to 500 MPa and 25 °C to 125 °C, respectively. Cyclic bipolar electric fields were applied with peak amplitudes of up to 6 MV m{sup −1} at each pressure and temperature combination. The resulting electric displacement–electric field hysteresis loops weremore » open “D” shaped at low pressure, characteristic of soft ferroelectric PZT. Just below the phase transformation pressure, the hysteresis loops took on an “S” shape, which split into a double hysteresis loop just above the phase transformation pressure. Far above the phase transformation pressure, when the applied electric field is insufficient to drive an antiferroelectric to ferroelectric phase transformation, the hysteresis loops collapse to linear dielectric behavior. Phase stability maps were generated from the experimental data at each of the temperature steps and used to form a three dimensional pressure–temperature–electric field phase diagram.« less

Particulate Formation from a Copper Oxide-Based Oxygen ...

EPA Pesticide Factsheets

Attrition behavior and particle loss of a copper oxide-based oxygen carrier from a methane chemical looping combustion (CLC) process was investigated in a fluidized bed reactor. The aerodynamic diameters of most elutriated particulates, after passing through a horizontal settling duct, range between 2 and 5 μm. A notable number of submicron particulates are also identified. Oxygen carrier attrition was observed to lead to increased CuO loss resulting from the chemical looping reactions, i.e., Cu is enriched in small particles generated primarily from fragmentation in the size range of 10-75 μm. Cyclic reduction and oxidation reactions in CLC have been determined to weaken the oxygen carrier particles, resulting in increased particulate emission rates when compared to oxygen carriers without redox reactions. The generation rate for particulates < 10 μm was found to decrease with progressive cycles over as-prepared oxygen carrier particles and then reach a steady state. The surface of the oxygen carrier is also found to be coarsened due to a Kirkendall effect, which also explains the enrichment of Cu on particle surfaces and in small particles. As a result, it is important to collect and reprocess small particles generated from chemical looping processes to reduce oxygen carrier loss. The redox reactions associated with chemical looping combustion play an important role in particle attrition in the fluidized bed. Reaction-induced local stresses, due to the r

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY83, Part 3 (Planning Design & Research Engr-Zytron Corp.)

DTIC Science & Technology

1983-01-01

MACNEIL CONSTR CO INC AIR FORCE ACADEMY COLORADO 77 77SCHEUNER MACNEIL CONSTR CO INC FORT CARSON COLORADO 51 51SCHEUNER MACNEIL CONSTR CO INC ALPENA ...69 69 WILSON DORIITORY MANAGEMENT CO ALPENA MICHIGAN 41 41 41 41 WILSON EXCAVATING & BLDG CONTR LEXINGTON KENTUCKY 86 86 86 86 WILSON F 5 0

[Pathogenic activity modulation of Escherichia coli TL+ toxin with an isolated protein of Giardia intestinalis and a synthetic peptide].

PubMed

Jiménez-Cardoso, E; Eligio-García, L; Jiménez-Cardoso, J M; Angeles-Anguiano, E; Tobilla-Mercado, J M; Castañeda, G

2001-01-01

It is know that a protein from Giardia intestinalis works as a substrate for V. cholerae and Escherichia coli. The toxic activity of both activates protein G form intestinal mucosa with a pathogenic activity results. In the present study, the pathogenic activity of subunit A of Vibrio cholerae toxin (ADP-ribosyltranferase) using isolated fragments from: Giardia intestinalis and a synthetic peptide were used as modulators in vivo. Adult Neo Zealand males rabbits with ileal loop were prepared and different mixtures of heat labile enterotoxin obtained from Escherichia coli H10407 and ARF protein isolated by electrofocusing from Giardia intestinalis Portland I were inoculated in the loops. The toxin activity was evaluated by luminal liquid secretion and cyclic AMP concentration in tissues (each loop). ADP ribosyltranferase activity was modulated, due to a decreased of luminal secretion and cAMP in tissues. Such results were seen when synthetic peptide and subunit A from Vibrio cholerae were used. The ADP ribosyltranferase activity of heat labile Escherichia coli and Vibrio cholerae toxins were modified by in vitro and in vivo interaction with ARF protein, which modified pathogenic effect over rabbits intestinal epithelium.

STRUCTURAL, SURFACE MORPHOLOGICAL AND MAGNETIC STUDIES OF Zn1-xFexS (x=0.00-0.10) DILUTED MAGNETIC SEMICONDUCTORS GROWN BY CO-PRECIPITATION METHOD

NASA Astrophysics Data System (ADS)

Hassan, M.; Ghazanfar, M.; Arooj, N.; Riaz, S.; Hussain, S. Sajjad; Naseem, S.

We have fabricated Zn1-xFexS (x=0.00, 0.02, 0.04, 0.06, 0.08 and 0.10) diluted magnetic semiconductors using co-precipitation method. X-ray diffraction patterns depict that Zn1-xFexS appears as a dominant phase with cubic zinc blende structure and nanoscale crystallite size. In addition, a secondary phase of rhombohedral ZnS also appears; however, no additional phase arises that primarily belongs to Fe dopant. Using Debye-Scherrer relation, the crystallite size is found to be in the range of 20-27nm, which is in good agreement with the crystallite size calculated using the Williamson-Hall (WH) plot method. The appearance of secondary phase provoked to study the residual strain using Stokes-Wilson equation, which is nearly consistent to that observed using WH plot method. The surface morphology, revealed using scanning electron microscopy, depicts non-uniform surface structure with a variety of grains and void dimensions. Hysteresis loops measured for Zn1-xFexS at room temperature (RT) illustrate a paramagnetic behavior at higher fields; however, small ferromagnetic behavior is evident due to the small openings of the measured hysteresis loops around the origin. The measured RT ferromagnetism reveals the potential spintronic device applications of the studied diluted magnetic semiconductors.

Intersecting solitons, amoeba, and tropical geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujimori, Toshiaki; Nitta, Muneto; Ohta, Kazutoshi

2008-11-15

We study the generic intersection (or web) of vortices with instantons inside, which is a 1/4 Bogomol'nyi-Prasad-Sommerfield state in the Higgs phase of five-dimensional N=1 supersymmetric U(N{sub C}) gauge theory on R{sub t}x(C*){sup 2}{approx_equal}R{sup 2,1}xT{sup 2} with N{sub F}=N{sub C} Higgs scalars in the fundamental representation. In the case of the Abelian-Higgs model (N{sub F}=N{sub C}=1), the intersecting vortex sheets can be beautifully understood in a mathematical framework of amoeba and tropical geometry, and we propose a dictionary relating solitons and gauge theory to amoeba and tropical geometry. A projective shape of vortex sheets is described by the amoeba. Vortexmore » charge density is uniformly distributed among vortex sheets, and negative contribution to instanton charge density is understood as the complex Monge-Ampere measure with respect to a plurisubharmonic function on (C*){sup 2}. The Wilson loops in T{sup 2} are related with derivatives of the Ronkin function. The general form of the Kaehler potential and the asymptotic metric of the moduli space of a vortex loop are obtained as a by-product. Our discussion works generally in non-Abelian gauge theories, which suggests a non-Abelian generalization of the amoeba and tropical geometry.« less

Force distribution in a semiflexible loop.

PubMed

Waters, James T; Kim, Harold D

2016-04-01

Loops undergoing thermal fluctuations are prevalent in nature. Ringlike or cross-linked polymers, cyclic macromolecules, and protein-mediated DNA loops all belong to this category. Stability of these molecules are generally described in terms of free energy, an average quantity, but it may also be impacted by local fluctuating forces acting within these systems. The full distribution of these forces can thus give us insights into mechanochemistry beyond the predictive capability of thermodynamics. In this paper, we study the force exerted by an inextensible semiflexible polymer constrained in a looped state. By using a simulation method termed "phase-space sampling," we generate the equilibrium distribution of chain conformations in both position and momentum space. We compute the constraint forces between the two ends of the loop in this chain ensemble using Lagrangian mechanics, and show that the mean of these forces is equal to the thermodynamic force. By analyzing kinetic and potential contributions to the forces, we find that the mean force acts in the direction of increasing extension not because of bending stress, but in spite of it. Furthermore, we obtain a distribution of constraint forces as a function of chain length, extension, and stiffness. Notably, increasing contour length decreases the average force, but the additional freedom allows fluctuations in the constraint force to increase. The force distribution is asymmetric and falls off less sharply than a Gaussian distribution. Our work exemplifies a system where large-amplitude fluctuations occur in a way unforeseen by a purely thermodynamic framework, and offers computational tools useful for efficient, unbiased simulation of a constrained system.

Force distribution in a semiflexible loop

PubMed Central

Waters, James T.; Kim, Harold D.

2017-01-01

Loops undergoing thermal fluctuations are prevalent in nature. Ringlike or cross-linked polymers, cyclic macromolecules, and protein-mediated DNA loops all belong to this category. Stability of these molecules are generally described in terms of free energy, an average quantity, but it may also be impacted by local fluctuating forces acting within these systems. The full distribution of these forces can thus give us insights into mechanochemistry beyond the predictive capability of thermodynamics. In this paper, we study the force exerted by an inextensible semiflexible polymer constrained in a looped state. By using a simulation method termed “phase-space sampling,” we generate the equilibrium distribution of chain conformations in both position and momentum space. We compute the constraint forces between the two ends of the loop in this chain ensemble using Lagrangian mechanics, and show that the mean of these forces is equal to the thermodynamic force. By analyzing kinetic and potential contributions to the forces, we find that the mean force acts in the direction of increasing extension not because of bending stress, but in spite of it. Furthermore, we obtain a distribution of constraint forces as a function of chain length, extension, and stiffness. Notably, increasing contour length decreases the average force, but the additional freedom allows fluctuations in the constraint force to increase. The force distribution is asymmetric and falls off less sharply than a Gaussian distribution. Our work exemplifies a system where large-amplitude fluctuations occur in a way unforeseen by a purely thermodynamic framework, and offers computational tools useful for efficient, unbiased simulation of a constrained system. PMID:27176436

Loop Quantum Cosmology.

PubMed

Bojowald, Martin

2008-01-01

Quantum gravity is expected to be necessary in order to understand situations in which classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical spacetime inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding spacetime is then modified. One particular theory is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. The main effects are introduced into effective classical equations, which allow one to avoid the interpretational problems of quantum theory. They give rise to new kinds of early-universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function, which allows an extension of quantum spacetime beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of spacetime arising in loop quantum gravity and its application to cosmology sheds light on more general issues, such as the nature of time. Supplementary material is available for this article at 10.12942/lrr-2008-4.

Photometric Properties for Selected Algol-type Binaries. VIII. The Triple Systems DI Peg and AF Gem Revisited

NASA Astrophysics Data System (ADS)

Yang, Yuan-Gui; Yang, Ying; Li, Shu-Zheng

2014-06-01

New extensive photometry for two triple binary stars, DI Peg and AF Gem, was performed from 2012 October to 2013 January, with two small telescopes at Xinglong station (XLs) of NAOC. From new multi-color observations and previously published ones in literature, the photometric models were (re)deduced using the updated Wilson-Devinney code. The results indicated that the low third lights exist in two classic Algol-type binaries, whose fill-out factors for the more massive components are fp = 78.2(± 0.4)% for DI Peg, and fp = 69.0(± 0.3)% for AF Gem, respectively. Through analyzing the O-C curves, the orbital periods for two binaries change in the complicated mode. The period of DI Peg possibly appears to show two light-time orbits, whose modulated periods are P 3 = 54.6(± 0.5) yr and P 4 = 23.0(± 0.6) yr, respectively. The inferred minimum masses for the inner and outer sub-stellar companions are M in = 0.095 M ⊙ and M out = 0.170 M ⊙, respectively. Therefore, DI Peg may be a quadruple star. The orbital period of AF Gem appears to show a continuous period decrease or a cyclic variation; the latter may be preferable. The cyclic oscillation, with a period of 120.3(± 2.5) yr, may be attributed to the light-time effect due to the third body. This kind of additional companion may extract angular momentum from the central system, which may play a key role in the evolution of the binary.

The value-adding CFO: an interview with Disney's Gary Wilson. Interview by Geraldine E. Willigan.

PubMed

Wilson, G

1990-01-01

Financing a company is more complex than ever-and more important to its economic success. The demands on a CFO are tremendous. Optimizing capital costs requires an unprecedented level of technical sophistication. Yet the best CFOs today are not mere technicians. They are also strategists and innovators. Gary Wilson exemplifies the new CFO. In his 5 years as executive vice president and CFO of the Walt Disney Company and his 12 years at Marriott Corporation, he has shown how the finance function can add value-not just account for it. How does a CFO create value for shareholders? "Just like all the great marketing and operating executives," Wilson says, "by being creative." To Wilson, being creative means rethinking assumptions and finding clever ways to achieve financial and strategic goals. Some of Wilson's innovative deal making-like the off-balance-sheet financing he used at Marriott-is well known. At Marriott, he discovered the power of separating the ownership of an asset from its control. Marriott's strength was in operations, yet the company had a great deal of money tied up in real estate. Growth would require even more investment in real estate. Wilson's solution was to sell the hotels-in effect, removing them and the debt used to finance them from the balance sheet-and contract to operate them. In this interview, Wilson gives his view of the role of finance in today's corporation and explains the thinking behind some of the successful deals he has engineered-including Disney's Silver Screen movie-making partnerships and Euro Disneyland.

Microfluidic Serial Dilution Circuit

PubMed Central

Paegel, Brian M.; Grover, William H.; Skelley, Alison M.; Mathies, Richard A.; Joyce, Gerald F.

2008-01-01

In vitro evolution of RNA molecules requires a method for executing many consecutive serial dilutions. To solve this problem, a microfluidic circuit has been fabricated in a three-layer glass-PDMS-glass device. The 400-nL serial dilution circuit contains five integrated membrane valves: three two-way valves arranged in a loop to drive cyclic mixing of the diluent and carryover, and two bus valves to control fluidic access to the circuit through input and output channels. By varying the valve placement in the circuit, carryover fractions from 0.04 to 0.2 were obtained. Each dilution process, which is comprised of a diluent flush cycle followed by a mixing cycle, is carried out with no pipeting, and a sample volume of 400 nL is sufficient for conducting an arbitrary number of serial dilutions. Mixing is precisely controlled by changing the cyclic pumping rate, with a minimum mixing time of 22 s. This microfluidic circuit is generally applicable for integrating automated serial dilution and sample preparation in almost any microfluidic architecture. PMID:17073422

Copper Regulates Cyclic AMP-Dependent Lipolysis

PubMed Central

Krishnamoorthy, Lakshmi; Cotruvo, Joseph A.; Chan, Jefferson; Kaluarachchi, Harini; Muchenditsi, Abigael; Pendyala, Venkata S.; Jia, Shang; Aron, Allegra T.; Ackerman, Cheri M.; Vander Wal, Mark N.; Guan, Timothy; Smaga, Lukas P.; Farhi, Samouil L.; New, Elizabeth J.; Lutsenko, Svetlana; Chang, Christopher J.

2016-01-01

Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium, and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme cofactors. Here we report that copper is an endogenous regulator of lipolysis, the breakdown of fat, which is an essential process in maintaining the body's weight and energy stores. Utilizing a murine model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we demonstrate that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. Biochemical studies of the copper-PDE3B interaction establish copper-dependent inhibition of enzyme activity and identify a key conserved cysteine residue within a PDE3-specific loop that is essential for the observed copper-dependent lipolytic phenotype. PMID:27272565

RNA repair: an antidote to cytotoxic eukaryal RNA damage.

PubMed

Nandakumar, Jayakrishnan; Schwer, Beate; Schaffrath, Raffael; Shuman, Stewart

2008-07-25

RNA healing and sealing enzymes drive informational and stress response pathways entailing repair of programmed 2',3' cyclic PO(4)/5'-OH breaks. Fungal, plant, and phage tRNA ligases use different strategies to discriminate the purposefully broken ends of the anticodon loop. Whereas phage ligase recognizes the tRNA fold, yeast and plant ligases do not and are instead hardwired to seal only the tRNA 3'-OH, 2'-PO(4) ends formed by healing of a cyclic phosphate. tRNA anticodon damage inflicted by secreted ribotoxins such as fungal gamma-toxin underlies a rudimentary innate immune system. Yeast cells are susceptible to gamma-toxin because the sealing domain of yeast tRNA ligase is unable to rectify a break at the modified wobble base of tRNA(Glu(UUC)). Plant andphage tRNA repair enzymes protect yeast from gamma-toxin because they are able to reverse the damage. Our studies underscore how a ribotoxin exploits an Achilles' heel in the target cell's tRNA repair system.

Some properties of purified Escherichia coli heat-stable enterotoxin II.

PubMed Central

Hitotsubashi, S; Fujii, Y; Yamanaka, H; Okamoto, K

1992-01-01

We examined the biological properties of purified Escherichia coli heat-stable enterotoxin II (STII) using mouse intestinal loop assays and compared these properties with those of heat-stable enterotoxin I (STI) and cholera toxin (CT). The action of STII over time differed from those of STI and CT. STII did not alter cyclic GMP or cyclic AMP levels in intestinal mucosal cells. Our results supported the idea that the mechanism of action of STII in inducing fluid secretion is different from the mechanisms of action of STI and CT. This hypothesis was further supported by the fact that an anti-STII neutralizing serum did not neutralize the activities of STI and CT. Subsequently, we examined the involvement of prostaglandins in the action of STII. The level of prostaglandin E2 in the fluid accumulated as a result of the action of STII increased, and the prostaglandin synthesis inhibitors aspirin and indomethacin significantly reduced the response to STII. These results implicate prostaglandin E2 in the mechanism of action of STII. Images PMID:1398961

Renormalization Group Theory, the Epsilon Expansion and Ken Wilson as I knew Him

NASA Astrophysics Data System (ADS)

Fisher, Michael E.

The tasks posed for renormalization group theory (RGT) within statistical physics by critical phenomena theory in the 1960's are set out briefly in contradistinction to quantum field theory (QFT), which was the origin for Ken Wilson's concerns. Kadanoff's 1966 block spin scaling picture and its difficulties are presented;Wilson's early vision of flows is described from the author's perspective. How Wilson's subsequent breakthrough ideas, published in 1971, led to the epsilon expansion and the resulting clarity is related. Concluding sections complete the general picture of flows in a space of Hamiltonians, universality and scaling. The article represents a 40% condensation (but with added items) of an earlier account: Rev. Mod. Phys. 70, 653-681 (1998).

Walter Baade, Fritz Zwicky, and Rudolph Minkowski's Early Supernova Research, 1927 - 1973

NASA Astrophysics Data System (ADS)

Osterbrock, D. E.

1999-12-01

Long before he ``discovered" the two stellar populations, Walter Baade was a pioneer in research on supernovae and their remnants. In 1927, while still in Germany, Baade emphasized what he called ``Hauptnovae" (chief novae) as highly luminous, potential distance indicators. He joined the Mount Wilson staff in 1931, bringing the ``secret" of the Schmidt camera with him, and encouraged Fritz Zwicky to carry out a supernova search with one at Palomar. Baade and Zwicky used the term ``supernova" in their 1933 joint paper. Zwicky began a systematic search in 1936, and Baade followed up with the 100-in reflector to derive light curves. He confirmed that Tycho's ``nova" of 1572 and the Crab nebula had been supernovae in our Galaxy. Baade advised N. U. Mayall, at Lick, on his spectroscopic study of the Crab nebula. In 1933, after Hitler came to power, Rudolph Minkowski had to leave Germany. Baade managed to get him a Mount Wilson staff position. Minkowski then did the spectroscopic observations of supernovae, beginning in 1937. Within a few years he and Baade were able to distinguish type I and II supernovae. Baade's further work on supernovae included historical research in Latin, Italian, and German, as well as filter photography. He searched hard for a remnant of SN 1885 in M 31, but never succeeded in finding it. After World War II the Crab nebula was found to be a strong radio source, and Baade and Minkowski used the 200-in to identify other supernova remnants, beginning with Cas A. Baade collaborated closely with Jan Oort and his student, Lo Woltjer, in their studies of the Crab nebula. After Baade retired in 1958, Minkowski continued supernova research for more than a decade; one of his favorite objects was the expanding Cygnus Loop.

Adventures in Topological Field Theory

NASA Astrophysics Data System (ADS)

Horne, James H.

1990-01-01

This thesis consists of 5 parts. In part I, the topological Yang-Mills theory and the topological sigma model are presented in a superspace formulation. This greatly simplifies the field content of the theories, and makes the Q-invariance more obvious. The Feynman rules for the topological Yang -Mills theory are derived. We calculate the one-loop beta-functions of the topological sigma model in superspace. The lattice version of these theories is presented. The self-duality constraints of both models lead to spectrum doubling. In part II, we show that conformally invariant gravity in three dimensions is equivalent to the Yang-Mills gauge theory of the conformal group in three dimensions, with a Chern-Simons action. This means that conformal gravity is finite and exactly soluble. In part III, we derive the skein relations for the fundamental representations of SO(N), Sp(2n), Su(m| n), and OSp(m| 2n). These relations can be used recursively to calculate the expectation values of Wilson lines in three-dimensional Chern-Simons gauge theory with these gauge groups. A combination of braiding and tying of Wilson lines completely describes the skein relations. In part IV, we show that the k = 1 two dimensional gravity amplitudes at genus 3 agree precisely with the results from intersection theory on moduli space. Predictions for the genus 4 intersection numbers follow from the two dimensional gravity theory. In part V, we discuss the partition function in two dimensional gravity. For the one matrix model at genus 2, we use the partition function to derive a recursion relation. We show that the k = 1 amplitudes completely determine the partition function at arbitrary genus. We present a conjecture for the partition function for the arbitrary topological field theory coupled to topological gravity.

Damage Evolution and Life Prediction of Cross-Ply C/SiC Ceramic-Matrix Composite under Cyclic Fatigue Loading at Room Temperature and 800 °C in Air

PubMed Central

Li, Longbiao

2015-01-01

The damage evolution and life prediction of cross-ply C/SiC ceramic-matrix composite (CMC) under cyclic-fatigue loading at room temperature and 800 °C in air have been investigated using damage parameters derived from fatigue hysteresis loops, i.e., fatigue hysteresis modulus and fatigue hysteresis loss energy. The experimental fatigue hysteresis modulus and fatigue hysteresis loss energy degrade with increasing applied cycles attributed to transverse cracks in the 90° plies, matrix cracks and fiber/matrix interface debonding in the 0° plies, interface wear at room temperature, and interface and carbon fibers oxidation at 800 °C in air. The relationships between fatigue hysteresis loops, fatigue hysteresis modulus and fatigue hysteresis loss energy have been established. Comparing experimental fatigue hysteresis loss energy with theoretical computational values, the fiber/matrix interface shear stress corresponding to different cycle numbers has been estimated. It was found that the degradation rate at 800 °C in air is much faster than that at room temperature due to serious oxidation in the pyrolytic carbon (PyC) interphase and carbon fibers. Combining the fiber fracture model with the interface shear stress degradation model and the fibers strength degradation model, the fraction of broken fibers versus the cycle number can be determined for different fatigue peak stresses. The fatigue life S-N curves of cross-ply C/SiC composite at room temperature and 800 °C in air have been predicted. PMID:28793728

Damage Evolution and Life Prediction of Cross-Ply C/SiC Ceramic-Matrix Composite under Cyclic Fatigue Loading at Room Temperature and 800 °C in Air.

PubMed

Li, Longbiao

2015-12-09

The damage evolution and life prediction of cross-ply C/SiC ceramic-matrix composite (CMC) under cyclic-fatigue loading at room temperature and 800 °C in air have been investigated using damage parameters derived from fatigue hysteresis loops, i.e. , fatigue hysteresis modulus and fatigue hysteresis loss energy. The experimental fatigue hysteresis modulus and fatigue hysteresis loss energy degrade with increasing applied cycles attributed to transverse cracks in the 90° plies, matrix cracks and fiber/matrix interface debonding in the 0° plies, interface wear at room temperature, and interface and carbon fibers oxidation at 800 °C in air. The relationships between fatigue hysteresis loops, fatigue hysteresis modulus and fatigue hysteresis loss energy have been established. Comparing experimental fatigue hysteresis loss energy with theoretical computational values, the fiber/matrix interface shear stress corresponding to different cycle numbers has been estimated. It was found that the degradation rate at 800 °C in air is much faster than that at room temperature due to serious oxidation in the pyrolytic carbon (PyC) interphase and carbon fibers. Combining the fiber fracture model with the interface shear stress degradation model and the fibers strength degradation model, the fraction of broken fibers versus the cycle number can be determined for different fatigue peak stresses. The fatigue life S-N curves of cross-ply C/SiC composite at room temperature and 800 °C in air have been predicted.

How Is Wilson Disease Diagnosed?

MedlinePlus

... Connect with Wilson Disease Association Send Email Physician Contacts List of Physicians and Institutions in Your Area View Contacts Support Contacts Individuals who can offer Support and Information View ...

Early tension loss in an anterior cruciate ligament graft. A cadaver study of four tibial fixation devices.

PubMed

Grover, Dustin M; Howell, Stephen M; Hull, Maury L

2005-02-01

The tensile force applied to an anterior cruciate ligament graft determines the maximal anterior translation; however, it is unknown whether the tensile force is transferred to the intra-articular portion of the graft and whether the intra-articular tension and maximal anterior translation are maintained shortly after ligament reconstruction. Ten cadaveric knees were reconstructed with a double-looped tendon graft. The graft was looped through a femoral fixation transducer that measured the resultant force on the proximal end of the graft. A pneumatic cylinder applied a tensile force of 110 N to the graft exiting the tibial tunnel with the knee in full extension. The graft was fixed sequentially with four tibial fixation devices (a spiked metal washer, double staples, a bioabsorbable interference screw, and a WasherLoc). Three cyclic loading treatments designed to conservatively load the graft and its fixation were applied. The combined loss in intra-articular graft tension from friction, insertion of the tibial fixation device, and three cyclic loading treatments was 50% for the spiked washer (p = 0.0004), 100% for the double staples (p < 0.0001), 64% for the interference screw (p = 0.0001), and 56% for the WasherLoc (p < 0.0001). The tension loss caused an increase in the maximal anterior translation from that of the intact knee of 2.0 mm for the spiked washer (p = 0.005), 7.8 mm for the double staples (p < 0.0001), 2.7 mm for the interference screw (p = 0.001), and 2.1 mm for the WasherLoc (p < 0.0001). The tensile force applied to a soft-tissue anterior cruciate ligament graft is not transferred intra-articularly and is not maintained during graft fixation. The loss in tension is caused by friction in the tibial tunnel and wrapping the graft around the shank of the screw of the spiked washer, insertion of the tibial fixation device, and cyclical loading of the knee. The amount of tension loss is sufficient to increase the maximal anterior translation.

Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.

PubMed

Lin, Kuan-Hung; Ali, Akbar; Rusere, Linah; Soumana, Djade I; Kurt Yilmaz, Nese; Schiffer, Celia A

2017-05-15

The mosquito-transmitted dengue virus (DENV) infects millions of people in tropical and subtropical regions. Maturation of DENV particles requires proper cleavage of the viral polyprotein, including processing of 8 of the 13 substrate cleavage sites by dengue virus NS2B/NS3 protease. With no available direct-acting antiviral targeting DENV, NS2/NS3 protease is a promising target for inhibitor design. Current design efforts focus on the nonprime side of the DENV protease active site, resulting in highly hydrophilic and nonspecific scaffolds. However, the prime side also significantly modulates DENV protease binding affinity, as revealed by engineering the binding loop of aprotinin, a small protein with high affinity for DENV protease. In this study, we designed a series of cyclic peptides interacting with both sides of the active site as inhibitors of dengue virus protease. The design was based on two aprotinin loops and aimed to leverage both key specific interactions of substrate sequences and the entropic advantage driving aprotinin's high affinity. By optimizing the cyclization linker, length, and amino acid sequence, the tightest cyclic peptide achieved a K i value of 2.9 μM against DENV3 wild-type (WT) protease. These inhibitors provide proof of concept that both sides of DENV protease active site can be exploited to potentially achieve specificity and lower hydrophilicity in the design of inhibitors targeting DENV. IMPORTANCE Viruses of the flaviviral family, including DENV and Zika virus transmitted by Aedes aegypti , continue to be a threat to global health by causing major outbreaks in tropical and subtropical regions, with no available direct-acting antivirals for treatment. A better understanding of the molecular requirements for the design of potent and specific inhibitors against flaviviral proteins will contribute to the development of targeted therapies for infections by these viruses. The cyclic peptides reported here as DENV protease inhibitors provide novel scaffolds that enable exploiting the prime side of the protease active site, with the aim of achieving better specificity and lower hydrophilicity than those of current scaffolds in the design of antiflaviviral inhibitors. Copyright © 2017 American Society for Microbiology.

Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain.

PubMed

Munir, Annum; Shuman, Stewart

2016-11-28

5' and 3' end healing are key steps in nucleic acid break repair in which 5' -OH ends are phosphorylated by a polynucleotide kinase and 3' -PO 4 or 2',3' -cyclic-PO 4 ends are hydrolyzed by a phosphoesterase to generate the 5' -PO 4 and 3' -OH termini required for sealing by classic polynucleotide ligases. End healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex. Here we identify and characterize Runella slithyformis HD-Pnk as a novel bifunctional end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase P-loop domain. HD-Pnk phosphorylates 5' -OH polynucleotides (9-mers or longer) in the presence of magnesium and any NTP donor. HD-Pnk dephosphorylates RNA 2',3' -cyclic phosphate, RNA 3' -phosphate, RNA 2' -phosphate, and DNA 3' -phosphate ends in the presence of a transition metal cofactor, which can be nickel, copper or cobalt. HD-Pnkp homologs are present in genera from eleven bacterial phyla and are often encoded in an operon with a putative ATP-dependent polynucleotide ligase. The present study provides insights to the diversity of nucleic acid repair strategies via the characterization of Runella slithyformis HD-Pnkp as the exemplar of a novel clade of dual 5' and 3' end-healing enzymes that phosphorylate 5' -OH termini and dephosphorylate 2',3' -cyclic-PO 4 , 3' -PO 4 , and 2' -PO 4 ends. The distinctive feature of HD-Pnk is its domain composition: a fusion of an N-terminal HD phosphohydrolase module to a C-terminal P-loop polynucleotide kinase module. Homologs of Runella HD-Pnk with the same domain composition, domain order, and similar polypeptide size are distributed widely among genera from eleven bacterial phyla. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Neurological features and management of Wilson disease in children: an evaluation of 12 cases.

PubMed

Bayram, Ayşe Kaçar; Gümüş, Hakan; Arslan, Duran; Özçora, Güldemet Kaya; Kumandaş, Sefer; Karacabey, Neslihan; Canpolat, Mehmet; Per, Hüseyin

2016-03-01

Wilson's disease is an autosomal recessive disorder of copper metabolism which leads to copper overload in different tissues of the body. The aim of this study was to present the neurologic features of Wilson's disease and to assess the clinical course of neurological findings in children receiving anti-copper treatment. Twelve children with a diagnosis of Wilson's disease and findings of central nervous system involvement who were followed up in the Department of Pediatric Neurology and Pediatric Gastroenterology of the School of Medicine at Erciyes University were enrolled in the study. The study cases consisted of five boys (42%) and seven girls (58%). The mean age at the time of diagnosis was 9.9±3.4 years (5-15 years). The mean duration of follow-up was 49.0±36.4 months (15-128 months). Neurological findings at presentation included headache in seven cases (58%), tremor in seven cases (58%), dystonia in three cases (25%), ataxia in two cases (17%), dizziness in two cases (17%), numbness in the hands and acute weakness in one case (8%) and syncope in one case (8%). Headache, dizziness, syncope, numbness in hands and acute weakness symptoms resolved completely within six months after receiving treatment. Movement disorders either decreased or remained stable in seven of the eight cases. However, one patient developed progressively worsening dystonia despite to all treatments. Wilson's disease can be manifested with signs and symptoms of central nervous system in the childhood. Wilson's disease should be considered in all children presenting with movement disorders. A complete neurological assessment should be carried out in all cases with Wilson's disease.

An Interactive Microcomputer Wargame for an Air Battle.

DTIC Science & Technology

1982-10-01

Monterey, California THESIS An Interactive Microcomputer Wargame for an Air Battle by James Owen Wilson October 1982 Thesis Advisor: A. F. Andrus...CONTIRCT 00 GRAN0T 186degg(.J James Owen Wilson 11101FRINA 111ANZATGN 0009 O GO498 1. PROGRAM 9L9060" . PRJr.AS S. ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ f9 PR@UN...Wargame for an Air Battle by James Owen Wilson Lieutenant, United States Navy oo B.A., University of Texas, 1974 Accession ForSubmitted in partial

Towards a nonperturbative calculation of weak Hamiltonian Wilson coefficients

DOE PAGES

Bruno, Mattia; Lehner, Christoph; Soni, Amarjit

2018-04-20

Here, we propose a method to compute the Wilson coefficients of the weak effective Hamiltonian to all orders in the strong coupling constant using Lattice QCD simulations. We perform our calculations adopting an unphysically light weak boson mass of around 2 GeV. We demonstrate that systematic errors for the Wilson coefficients C 1 and C 2, related to the current-current four-quark operators, can be controlled and present a path towards precise determinations in subsequent works.

Towards a nonperturbative calculation of weak Hamiltonian Wilson coefficients

NASA Astrophysics Data System (ADS)

Bruno, Mattia; Lehner, Christoph; Soni, Amarjit; Rbc; Ukqcd Collaborations

2018-04-01

We propose a method to compute the Wilson coefficients of the weak effective Hamiltonian to all orders in the strong coupling constant using Lattice QCD simulations. We perform our calculations adopting an unphysically light weak boson mass of around 2 GeV. We demonstrate that systematic errors for the Wilson coefficients C1 and C2 , related to the current-current four-quark operators, can be controlled and present a path towards precise determinations in subsequent works.

Towards a nonperturbative calculation of weak Hamiltonian Wilson coefficients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bruno, Mattia; Lehner, Christoph; Soni, Amarjit

Here, we propose a method to compute the Wilson coefficients of the weak effective Hamiltonian to all orders in the strong coupling constant using Lattice QCD simulations. We perform our calculations adopting an unphysically light weak boson mass of around 2 GeV. We demonstrate that systematic errors for the Wilson coefficients C 1 and C 2, related to the current-current four-quark operators, can be controlled and present a path towards precise determinations in subsequent works.

Photometric study and absolute parameters of the short-period eclipsing binary HH Bootis

NASA Astrophysics Data System (ADS)

Gürol, B.; Bradstreet, D. H.; Demircan, Y.; Gürsoytrak, S. H.

2015-11-01

We present the results of our investigation on the geometrical and physical parameters of the W UMa type binary system HH Bootis from new CCD (BVRI) light curves and published radial velocity data. The photometric data were obtained in 2011 and 2012 at Ankara University Observatory (AUO). Light and radial velocity observations were analyzed simultaneously using the Wilson-Devinney (2013 revision) code to obtain absolute and geometrical parameters. The system was determined to be a W-type W UMa system of a type different from that suggested by Dal and Sipahi (2013). An interesting cyclic period variation in the time intervals between primary and secondary eclipses ("half-period variation") was discovered and analyzed and its possible cause is discussed. Combining our photometric solution with the spectroscopic data we derived masses and radii of the eclipsing system to be M1 = 0.627M⊙ , M2 = 1.068M⊙ , R1 = 0.782R⊙ and R2 = 0.997R⊙ . New light elements were derived and finally the evolutionary status of the system is discussed.

77 FR 49439 - National Security Education Board Members Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

.... ADDRESSES: Defense Language and National Security Education Office, 1101 Wilson Boulevard, Suite 1210... National Security Education Office (DLNSEO), 1101 Wilson Boulevard, Suite 1210, Rosslyn, Virginia 22209...

The treatment of Wilson's disease, a rare genetic disorder of copper metabolism.

PubMed

Purchase, Rupert

2013-01-01

Wilson's disease is a rare autosomal recessive disease characterised by the deposition of copper in the brain, liver; cornea, and other organs. The overload of copper inevitably leads to progressive liver and neurological dysfunction. Copper overload in patients with Wilson's disease is caused by impairment to the biliary route for excretion of dietary copper A combination of neurological, psychiatric and hepatic symptoms can make the diagnosis of Wilson's disease challenging. Most symptoms appear in the second and third decades of life. The disease affects between one in 30,000 and one in 100,000 individuals, and is fatal if left untreated. Five drugs are currently available to treat Wilson's disease: British Anti-Lewisite; D-penicillamine; trientine; zinc sulfate or acetate; and ammonium tetrathiomolybdate. Each drug can reduce copper levels and/or transform copper into a metabolically inert and unavailable form in the patient. The discovery and introduction of these five drugs owes more to the inspiration of a few dedicated physicians and agricultural scientists than to the resources of the pharmaceutical industry.

HFE gene mutations and Wilson's disease in Sardinia.

PubMed

Sorbello, Orazio; Sini, Margherita; Civolani, Alberto; Demelia, Luigi

2010-03-01

Hypocaeruloplasminaemia can lead to tissue iron storage in Wilson's disease and the possibility of iron overload in long-term overtreated patients should be considered. The HFE gene encodes a protein that is intimately involved in intestinal iron absorption. The aim of this study was to determine the prevalence of the HFE gene mutation, its role in iron metabolism of Wilson's disease patients and the interplay of therapy in copper and iron homeostasis. The records of 32 patients with Wilson's disease were reviewed for iron and copper indices, HFE gene mutations and liver biopsy. Twenty-six patients were negative for HFE gene mutations and did not present significant alterations of iron metabolism. The HFE mutation was significantly associated with increased hepatic iron content (P<0.02) and transferrin saturation index (P<0.03). After treatment period, iron indices were significantly decreased only in HFE gene wild-type. The HFE gene mutations may be an addictional factor in iron overload in Wilson's disease. Our results showed that an adjustment of dosage of drugs could prevent further iron overload induced by overtreatment only in patients HFE wild-type. 2009. Published by Elsevier Ltd.

Diet of Wilson's warblers and distribution of arthropod prey in the understory of Douglas-fir forests

USGS Publications Warehouse

Hagar, Joan C.; Dugger, Kate; Starkey, Edward E.

2007-01-01

Availability of food resources is an important factor in avian habitat selection. Food resources for terrestrial birds often are closely related to vegetation structure and composition. Identification of plant species important in supporting food resources may facilitate vegetation management to achieve objectives for providing bird habitat. We used fecal analysis to describe the diet of adult Wilson's Warblers (Wilsonia pusilla) that foraged in the understory of Douglas-fir (Pseudotsuga menziesii) forests in western Oregon during the breeding season. We sampled arthropods at the same sites where diet data were collected, and compared abundance and biomass of prey among seven common shrub species. Wilson's Warblers ate more caterpillars (Lepidoptera larvae), flies (Diptera), beetles (Coleoptera), and Homoptera than expected based on availability. Deciduous shrubs supported higher abundances of arthropod taxa and size classes used as prey by Wilson's Warblers than did evergreen shrubs. The development and maintenance of deciduous understory vegetation in conifer forests of the Pacific Northwest may be fundamental for conservation of food webs that support breeding Wilson's Warblers and other shrub-associated, insectivorous songbirds.

Arthropod prey of Wilson's Warblers in the understory of Douglas-fir forests

USGS Publications Warehouse

Hagar, J.C.; Dugger, K.M.; Starkey, E.E.

2007-01-01

Availability of food resources is an important factor in avian habitat selection. Food resources for terrestrial birds often are closely related to vegetation structure and composition. Identification of plant species important in supporting food resources may facilitate vegetation management to achieve objectives for providing bird habitat. We used fecal analysis to describe the diet of adult Wilson's Warblers (Wilsonia pusilla) that foraged in the understory of Douglas-fir (Pseudotsuga menziesii) forests in western Oregon during the breeding season. We sampled arthropods at the same sites where diet data were collected, and compared abundance and biomass of prey among seven common shrub species. Wilson's Warblers ate more caterpillars (Lepidoptera larvae), flies (Diptera), beetles (Coleoptera), and Homoptera than expected based on availability. Deciduous shrubs supported higher abundances of arthropod taxa and size classes used as prey by Wilson's Warblers than did evergreen shrubs. The development and maintenance of deciduous understory vegetation in conifer forests of the Pacific Northwest may be fundamental for conservation of food webs that support breeding Wilson's Warblers and other shrub-associated, insectivorous songbirds.

Diet and Nutrition

MedlinePlus

... need to know about Wilson Disease Diet and Nutrition Food . . . . Adherence to a low copper diet is ... Symptoms Diagnosis Treatments Generic Zinc Options Inheritence Diet & Nutrition Kayser-Fleischer Rings Wilson Disease FAQs Definitions Transplantation ...

Officer Career Development: Measures and Samples in the 1981-1989 Research Program

DTIC Science & Technology

1991-03-01

and Samples in the 1981-1989 Research Program Gerry L. Wilcove William C . Wilson DTIC S ELECTE APR25 19911 EU Approved for public release: distibution...Wilcove William C . Wilson A oosst~on For NIS GRA&I ’ -DTIC TAB Unannounced Q Just if I cation-,--, Reviewed by Distribution/ Robert F. Morrison...1989 Program Element 0602233N, Research Program Work Unit RM33M20.06 6. AUTHOR(S) Gerry L. Wilcove, William C . Wilson 7. PERFORMING ORGANIZATION NAME

Cyclic coding for Brillouin optical time-domain analyzers using probe dithering.

PubMed

Iribas, Haritz; Loayssa, Alayn; Sauser, Florian; Llera, Miguel; Le Floch, Sébastien

2017-04-17

We study the performance limits of mono-color cyclic coding applied to Brillouin optical time-domain analysis (BOTDA) sensors that use probe wave dithering. BOTDA analyzers with dithering of the probe use a dual-probe-sideband setup in which an optical frequency modulation of the probe waves along the fiber is introduced. This avoids non-local effects while keeping the Brillouin threshold at its highest level, thus preventing the spontaneous Brillouin scattering from generating noise in the deployed sensing fiber. In these conditions, it is possible to introduce an unprecedented high probe power into the sensing fiber, which leads to an enhancement of the signal-to-noise ratio (SNR) and consequently to a performance improvement of the analyzer. The addition of cyclic coding in these set-ups can further increase the SNR and accordingly enhance the performance. However, this unprecedented probe power levels that can be employed result in the appearance of detrimental effects in the measurement that had not previously been observed in other BOTDA set-ups. In this work, we analyze the distortion in the decoding process and the errors in the measurement that this distortion causes, due to three factors: the power difference of the successive pulses of a code sequence, the appearance of first-order non-local effects and the non-linear amplification of the probe wave that results when using mono-color cyclic coding of the pump pulses. We apply the results of this study to demonstrate the performance enhancement that can be achieved in a long-range dithered dual-probe BOTDA. A 164-km fiber-loop is measured with 1-m spatial resolution, obtaining 3-MHz Brillouin frequency shift measurement precision at the worst contrast location. To the best of our knowledge, this is the longest sensing distance achieved with a BOTDA sensor using mono-color cyclic coding.

Ratcheting fatigue behaviour of Al-7075 T6 alloy: Influence of stress parameters

NASA Astrophysics Data System (ADS)

Amarnath, Lala; Bhattacharjee, Antara; Dutta, K.

2016-02-01

The use of aluminium and aluminium based alloys are increasing rapidly on account of its high formability, good thermal and electrical conductivity, high strength and lightness. Aluminium alloys are extensively used in aerospace, automobile, marine and space research industries and are also put into structural applications where chances of fatigue damage cannot be ruled out. In the current work, it is intended to study the ratcheting fatigue behavior of 7075-T6 aluminium alloy at room temperature. This Al alloy is potentially used in aviation, marine and automotive components as well as in bicycle parts, rock mounting equipment and parts of ammunition where there is every chance of failure of the parts due to deformation caused by ratcheting. Ratcheting is the process of accruement of plastic stain produced when a component is subjected to asymmetric cyclic loading under the influence of low cycle fatigue. To accomplish the requirements of the projected research, stress-controlled cyclic loading experiments were done using a ±250 kN servo-hydraulic universal testing machine (Instron: 8800R). The effect of stress parameters such as mean stress and stress amplitude were investigated on the ratcheting behavior of the selected aluminium alloy. It was observed that, ratcheting strain increased with increase in the value of stress amplitude at any constant mean stress while a saturation in strain accumulation attained in the investigated material after around 10-20 cycles, under all test conditions. The analyses of hysteresis loop generated during cyclic loading indicate that the material exhibits cyclic hardening in the initial fifty cycles which gets softened in further loading up to about 70-80 cycles and finally attains a steady state. The increase in the ratcheting strain value with stress parameters happens owing to increased deformation domain during cycling. The cyclic hardening accompanied by softening is correlated with characteristic precipitation features of the investigated Al 7075 alloy.

Chern-Simons-Rozansky-Witten topological field theory

NASA Astrophysics Data System (ADS)

Kapustin, Anton; Saulina, Natalia

2009-12-01

We construct and study a new topological field theory in three dimensions. It is a hybrid between Chern-Simons and Rozansky-Witten theory and can be regarded as a topologically-twisted version of the N=4d=3 supersymmetric gauge theory recently discovered by Gaiotto and Witten. The model depends on a gauge group G and a hyper-Kähler manifold X with a tri-holomorphic action of G. In the case when X is an affine space, we show that the model is equivalent to Chern-Simons theory whose gauge group is a supergroup. This explains the role of Lie superalgebras in the construction of Gaiotto and Witten. For general X, our model appears to be new. We describe some of its properties, focusing on the case when G is simple and X is the cotangent bundle of the flag variety of G. In particular, we show that Wilson loops are labeled by objects of a certain category which is a quantum deformation of the equivariant derived category of coherent sheaves on X.

Functional determinants of radial operators in AdS 2

NASA Astrophysics Data System (ADS)

Aguilera-Damia, Jeremías; Faraggi, Alberto; Zayas, Leopoldo Pando; Rathee, Vimal; Silva, Guillermo A.

2018-06-01

We study the zeta-function regularization of functional determinants of Laplace and Dirac-type operators in two-dimensional Euclidean AdS 2 space. More specifically, we consider the ratio of determinants between an operator in the presence of background fields with circular symmetry and the free operator in which the background fields are absent. By Fourier-transforming the angular dependence, one obtains an infinite number of one-dimensional radial operators, the determinants of which are easy to compute. The summation over modes is then treated with care so as to guarantee that the result coincides with the two-dimensional zeta-function formalism. The method relies on some well-known techniques to compute functional determinants using contour integrals and the construction of the Jost function from scattering theory. Our work generalizes some known results in flat space. The extension to conformal AdS 2 geometries is also considered. We provide two examples, one bosonic and one fermionic, borrowed from the spectrum of fluctuations of the holographic 1/4 -BPS latitude Wilson loop.

Toward autonomous spacecraft

NASA Technical Reports Server (NTRS)

Fogel, L. J.; Calabrese, P. G.; Walsh, M. J.; Owens, A. J.

1982-01-01

Ways in which autonomous behavior of spacecraft can be extended to treat situations wherein a closed loop control by a human may not be appropriate or even possible are explored. Predictive models that minimize mean least squared error and arbitrary cost functions are discussed. A methodology for extracting cyclic components for an arbitrary environment with respect to usual and arbitrary criteria is developed. An approach to prediction and control based on evolutionary programming is outlined. A computer program capable of predicting time series is presented. A design of a control system for a robotic dense with partially unknown physical properties is presented.

Conformational and receptor-binding properties of the insect neuropeptide proctolin and its analogues

NASA Astrophysics Data System (ADS)

Odell, Barbara; Hammond, Stephen J.; Osborne, Richard; Goosey, Michael W.

1996-04-01

Proctolin (Arg-Tyr-Leu-Pro-Thr) was the first insect neuropeptide to be chemically characterised. It plays an essential role in insect neurophysiology and is involved in muscular contraction and neuromodulation. Elements of secondary structure in solution have been studied by comparing data obtained from NMR and molecular dynamics simulations. Different secondary structural requirements are associated with agonist and antagonist activities. A favoured conformation of proctolin has an inverse γ-turn, comprising an intramolecular hydrogen bond near the C-terminal end between Thr NH and Leu CO. Antagonists have a more compact structure resembling a `paperclip' loop, containing an intramolecular hydrogen bond between Tyr NH and Pro CO, possibly stabilised by a salt bridge between the N- and C-terminal groups. A cyclic analogue retains antagonist activity and resembles a β-bulge loop, also comprising intramolecular hydrogen bonds between Tyr NH and Pro CO and Thr CO. These models may offer feasible starting points for designing novel compounds with proctolinergic activity.

32. GENERAL VIEW LOOKING NORTHEAST, SHOWING DRAFT CONES AND INTAKE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. GENERAL VIEW LOOKING NORTHEAST, SHOWING DRAFT CONES AND INTAKE TUBES. - Wilson Dam & Hydroelectric Plant, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

PHOTOMETRIC PROPERTIES FOR SELECTED ALGOL-TYPE BINARIES. II. AO SERPENTIS AND V338 HERCULIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Y.-G.; Dai, H.-F.; Hu, S.-M.

2010-04-15

We present the first multiband photometry for the semidetached eclipsing binary AO Serpentis, observed on seven nights between 2009 April and July at the Weihai Observatory of Shandong University. By using the 2003 version of the Wilson-Devinney code, the photometric solutions of AO Ser and a similar object V338 Her were (re)deduced. The spectral types and orbital periods are A2 and P = 0.8793 days for AO Ser, F1V and P = 1.3057 days for V338 Her. The results reveal that two binaries are low mass ratio systems, whose secondary components fill their Roche lobes. The fill-out factors of themore » primary components are f = 58.6% for AO Ser and f = 54.2% for V338 Her, respectively. From the O - C curves of AO Ser and V338 Her, it is discovered that secular period changes with cyclic variations exist. The periods and semiamplitudes are 17.32({+-}0.01) yr and 0.0051({+-}0.0001) days for AO Ser, 29.07({+-}0.04) yr and 0.0116({+-}0.0015) days for V338 Her, respectively. This kind of cyclic oscillation may be attributed to either the light-time effect via an assumed third body or perhaps cyclic magnetic activity on the secondary component. For AO Ser, the long-term period decreases at a rate of dP/dt = -5.35({+-}0.03) x 10{sup -7} days yr{sup -1}, which may be caused by mass and angular momentum loss from the system. Considering the period decreasing, the fill-out factor of the primary for AO Ser will increase and it will finally fill its Roche lobe. Meanwhile, the secular period increase rate for V338 Her is dP/dt = +1.44({+-}0.24) x 10{sup -7} days yr{sup -1}, indicating that mass transfers from the less massive component to the more massive component. This will also cause the fill-out factor of the primary to increase. When the primaries fill their Roche lobes, AO Ser and V338 Her may evolve into contact stars, as predicted by the theory of thermal relaxation oscillations.« less

The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels.

PubMed

Sartiani, Laura; Mannaioni, Guido; Masi, Alessio; Novella Romanelli, Maria; Cerbai, Elisabetta

2017-10-01

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels are important members of the voltage-gated pore loop channels family. They show unique features: they open at hyperpolarizing potential, carry a mixed Na/K current, and are regulated by cyclic nucleotides. Four different isoforms have been cloned (HCN1-4) that can assemble to form homo- or heterotetramers, characterized by different biophysical properties. These proteins are widely distributed throughout the body and involved in different physiologic processes, the most important being the generation of spontaneous electrical activity in the heart and the regulation of synaptic transmission in the brain. Their role in heart rate, neuronal pacemaking, dendritic integration, learning and memory, and visual and pain perceptions has been extensively studied; these channels have been found also in some peripheral tissues, where their functions still need to be fully elucidated. Genetic defects and altered expression of HCN channels are linked to several pathologies, which makes these proteins attractive targets for translational research; at the moment only one drug (ivabradine), which specifically blocks the hyperpolarization-activated current, is clinically available. This review discusses current knowledge about HCN channels, starting from their biophysical properties, origin, and developmental features, to (patho)physiologic role in different tissues and pharmacological modulation, ending with their present and future relevance as drug targets. Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

Cyclic Behavior of Mortarless Brick Joints with Different Interlocking Shapes

PubMed Central

Liu, Hongjun; Liu, Peng; Lin, Kun; Zhao, Sai

2016-01-01

The framed structure infilled with a mortarless brick (MB) panel exhibits considerable in-plane energy dissipation because of the relative sliding between bricks and good out-of-plane stability resulting from the use of interlocking mechanisms. The cyclic behaviors of MB are investigated experimentally in this study. Two different types of bricks, namely non-interlocking mortarless brick (N-IMB) and interlocking mortarless brick (IMB), are examined experimentally. The cyclic behavior of all of the joints (N-IMB and IMB) are investigated in consideration of the effects of interlocking shapes, loading compression stress levels and loading cycles. The hysteretic loops of N-IMB and IMB joints are obtained, according to which a mechanical model is developed. The Mohr–Coulomb failure criterion is employed to describe the shear failure modes of all of the investigated joints. A typical frictional behavior is observed for the N-IMB joints, and a significant stiffening effect is observed for the IMB joints during their sliding stage. The friction coefficients of all of the researched joints increase with the augmentation of the compression stress level and improvement of the smoothness of the interlocking surfaces. An increase in the loading cycle results in a decrease in the friction coefficients of all of the joints. The degradation rate (DR) of the friction coefficients increases with the reduction in the smoothness of the interlocking surface. PMID:28773291

75 FR 25844 - Federal Advisory Committee; National Security Education Board Members Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-10

... Education Program; 1101 Wilson Blvd., Suite 1210; Rosslyn, VA 22219. FOR FURTHER INFORMATION CONTACT: Dr. Kevin Gormley, Program Officer, National Security Education Program, 1101 Wilson Boulevard, Suite 1210...

77 FR 34029 - National Security Education Board Members Meeting; Cancellation of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

.... to 2 p.m. at Defense Language and National Security Education Office, 1101 Wilson Boulevard, Suite..., Defense Language and National Security Education Office (DLNSEO), 1101 Wilson Boulevard, Suite 1210...

INTERIOR VIEW LOOKING AT THE OILOSTATIC RESERVOIR AND PRESSURIZING TANKS. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW LOOKING AT THE OILOSTATIC RESERVOIR AND PRESSURIZING TANKS. - Wilson Dam & Hydroelectric Plant, Oilostatic Transmission System, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

Wilson's Disease Association International

MedlinePlus

... of Colorado and graduated with a B.S. in finance. Latest News & Announcements Search Our Site About WDA ... Help Donate Volunteer Shop Online Search the Internet Corporate Sponsorship Marketplace Copyright © 1978 - 2017 The Wilson Disease ...

1. Historic American Buildings Survey Samuel Wilson, Jr., Photographer, November ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Samuel Wilson, Jr., Photographer, November 30, 1934 VIEW OF TOWER ACROSS BLIND BAY MARSH - Frank's Island Lighthouse, North East Pass, Mississippi River, Boothville, Plaquemines Parish, LA

4. Historic American Buildings Survey, Glenn C. Wilson, Photographer March ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, Glenn C. Wilson, Photographer March 1, 1934 VIEW OF SOUTHWEST CORNER, SHOWING RECENT ADDITION. - Friederich Homann Saddlery & Residence, 136 Seguin Street, New Braunfels, Comal County, TX

General results for higher spin Wilson lines and entanglement in Vasiliev theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hegde, Ashwin; Kraus, Per; Perlmutter, Eric

Here, we develop tools for the efficient evaluation of Wilson lines in 3D higher spin gravity, and use these to compute entanglement entropy in the hs[λ ] Vasiliev theory that governs the bulk side of the duality proposal of Gaberdiel and Gopakumar. Our main technical advance is the determination of SL(N) Wilson lines for arbitrary N, which, in suitable cases, enables us to analytically continue to hs[λ ] via N→ -λ. We then apply this result to compute various quantities of interest, including entanglement entropy expanded perturbatively in the background higher spin charge, chemical potential, and interval size. This includesmore » a computation of entanglement entropy in the higher spin black hole of the Vasiliev theory. Our results are consistent with conformal field theory calculations. We also provide an alternative derivation of the Wilson line, by showing how it arises naturally from earlier work on scalar correlators in higher spin theory. The general picture that emerges is consistent with the statement that the SL(N) Wilson line computes the semiclassical W N vacuum block, and our results provide an explicit result for this object.« less

General results for higher spin Wilson lines and entanglement in Vasiliev theory

DOE PAGES

Hegde, Ashwin; Kraus, Per; Perlmutter, Eric

2016-01-28

Here, we develop tools for the efficient evaluation of Wilson lines in 3D higher spin gravity, and use these to compute entanglement entropy in the hs[λ ] Vasiliev theory that governs the bulk side of the duality proposal of Gaberdiel and Gopakumar. Our main technical advance is the determination of SL(N) Wilson lines for arbitrary N, which, in suitable cases, enables us to analytically continue to hs[λ ] via N→ -λ. We then apply this result to compute various quantities of interest, including entanglement entropy expanded perturbatively in the background higher spin charge, chemical potential, and interval size. This includesmore » a computation of entanglement entropy in the higher spin black hole of the Vasiliev theory. Our results are consistent with conformal field theory calculations. We also provide an alternative derivation of the Wilson line, by showing how it arises naturally from earlier work on scalar correlators in higher spin theory. The general picture that emerges is consistent with the statement that the SL(N) Wilson line computes the semiclassical W N vacuum block, and our results provide an explicit result for this object.« less

Photometric properties for selected algol-type binaries. VIII. The triple systems DI Peg and AF Gem revisited

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Yuan-Gui; Li, Shu-Zheng; Yang, Ying, E-mail: yygcn@163.com, E-mail: yangyg@chnu.edu.cn, E-mail: yangy818@yeah.net

2014-06-01

New extensive photometry for two triple binary stars, DI Peg and AF Gem, was performed from 2012 October to 2013 January, with two small telescopes at Xinglong station (XLs) of NAOC. From new multi-color observations and previously published ones in literature, the photometric models were (re)deduced using the updated Wilson-Devinney code. The results indicated that the low third lights exist in two classic Algol-type binaries, whose fill-out factors for the more massive components are f{sub p} = 78.2(± 0.4)% for DI Peg, and f{sub p} = 69.0(± 0.3)% for AF Gem, respectively. Through analyzing the O–C curves, the orbital periodsmore » for two binaries change in the complicated mode. The period of DI Peg possibly appears to show two light-time orbits, whose modulated periods are P {sub 3} = 54.6(± 0.5) yr and P {sub 4} = 23.0(± 0.6) yr, respectively. The inferred minimum masses for the inner and outer sub-stellar companions are M {sub in} = 0.095 M {sub ☉} and M {sub out} = 0.170 M {sub ☉}, respectively. Therefore, DI Peg may be a quadruple star. The orbital period of AF Gem appears to show a continuous period decrease or a cyclic variation; the latter may be preferable. The cyclic oscillation, with a period of 120.3(± 2.5) yr, may be attributed to the light-time effect due to the third body. This kind of additional companion may extract angular momentum from the central system, which may play a key role in the evolution of the binary.« less

Is There a Substellar Object Orbiting the Solar-like Stable Contact Binary V2284 Cyg?

NASA Astrophysics Data System (ADS)

Wang, J.-J.; Jiang, L.-Q.; Zhang, B.; Zhao, S.-Q.; Yu, J.

2017-12-01

V2284 Cyg is a neglected W UMa-type binary star for photometric investigations. Monitored by the Kepler Space Telescope from 2009 to 2013, its light curves are continuously stable, suggesting that both components are inactive during this time interval. Based on the short-cadence observations, we determined the photometric solutions by using the 2013 version of the Wilson-Devinney code. These parameters reveal that V2284 Cyg is a W-type system with a degree of contact factor of f = 39.23% and a mass ratio of q = 2.90. Meanwhile, hundreds of times of minimum light were obtained and applied to analyze the orbital period changes. In the O-C diagram, a small-amplitude cyclic oscillation (A 3 = 0.00030 days and T 3 = 2.06 years) superimposed on a secular decreasing was found. The continuous decreasing may be a result from the mass transfer from the more massive component to the less massive one. With the long-term decreasing of the orbital period, this binary will evolve into a deeper contact system. Because the light curve is stable, the cyclic variation is plausibly explained as the light-travel time effect (LTTE) due to the presence of an additional body. The mass of the companion is {M}3\\sin i\\prime =0.036(+/- 0.003) {M}⊙ . If the orbital plane inclination is a random distribution, it is a brown dwarf with 66.7% probability. Therefore, the companion of V2284 Cyg is possibly the first candidate of the brown dwarf orbiting around contact binary, where both component are sharing a common convective envelope.

THE FIRST PHOTOMETRIC INVESTIGATION OF THE NEGLECTED W-UMa-TYPE BINARY STAR UZ CMi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qian, S.-B.; Li, K.; Liao, W.-P.

2013-04-15

UZ CMi was a W-UMa-type binary star found more than 80 years ago. However, it has been neglected in photometric investigations. Here, the first complete light curves in the B, V, R, and I bands are presented and analyzed using the Wilson and Devinney method. It is discovered that UZ CMi is a contact binary (f = 38.4({+-} 2.3)%) with a mass ratio of 0.45. The derived orbital inclination (i = 87 Degree-Sign ) indicates that it is a total eclipsing binary, which suggests that the determined parameters are reliable. By using 17 new eclipse times together with those collectedmore » from the literature, we found that the general trend of the observed-calculated (O - C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of P-dot = +4.1 x 10{sup -8} days yr{sup -1}. The continuous increase may be caused by a mass transfer from the less massive component to the more massive one. This suggests that UZ CMi is in the thermal relaxation oscillation controlled stage of the evolutionary scheme proposed by Qian. UZ CMi will oscillate around a critical mass ratio and the contact configuration cannot be broken. After the upward parabolic change was removed, the (O - C){sub 2} curve of the photoelectric and charge-coupled device data revealed a cyclic variation with a small amplitude of 0.0026 days and a period of 21.1 yr. The cyclic change was analyzed for the light-travel time effect via the presence of an extremely cool stellar companion.« less

EXTERIOR VIEW SHOWING THE OILOSTATIC TERMINALS IN THE GENERATING PLANT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

EXTERIOR VIEW SHOWING THE OILOSTATIC TERMINALS IN THE GENERATING PLANT SWITCH YARD. - Wilson Dam & Hydroelectric Plant, Oilostatic Transmission System, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

29. VIEW LOOKING DOWN AT A DRAFT CONE AND FORMWORK ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. VIEW LOOKING DOWN AT A DRAFT CONE AND FORMWORK FOR A SPIRAL DISTRIBUTOR. - Wilson Dam & Hydroelectric Plant, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

26. GENERAL VIEW LOOKING NORTH SHOWING THE STRUCTURAL PIERS AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. GENERAL VIEW LOOKING NORTH SHOWING THE STRUCTURAL PIERS AND DRAFT CONE UNDER CONSTRUCTION. - Wilson Dam & Hydroelectric Plant, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

Wilson's Disease

MedlinePlus

... Kidney problems. Wilson's disease can damage the kidneys, leading to problems such as kidney stones and an abnormal number of amino acids excreted in the urine. Psychological problems. These might include personality changes, depression, irritability, bipolar disorder or psychosis. Blood problems. ...

Did Winston Churchill suffer a myocardial infarction in the White House at Christmas 1941?

PubMed

Vale, J Allister; Scadding, John W

2017-12-01

While staying in the White House over Christmas 1941, Churchill developed chest pain on trying to open a window in his bedroom. Sir Charles Wilson, his personal physician, diagnosed a 'heart attack' (myocardial infarction). Wilson, for political and personal reasons, decided not to inform his patient of the diagnosis or obtain assistance from US medical colleagues. On Churchill's return to London, Wilson sought a second opinion from Dr John Parkinson who did not support the diagnosis of coronary thrombosis (myocardial infarction) and reassured Churchill accordingly.

Comparisons of Damage Evolution between 2D C/SiC and SiC/SiC Ceramic-Matrix Composites under Tension-Tension Cyclic Fatigue Loading at Room and Elevated Temperatures

PubMed Central

Li, Longbiao

2016-01-01

In this paper, comparisons of damage evolution between 2D C/SiC and SiC/SiC ceramic-matrix composites (CMCs) under tension–tension cyclic fatigue loading at room and elevated temperatures have been investigated. Fatigue hysteresis loops models considering multiple matrix cracking modes in 2D CMCs have been developed based on the damage mechanism of fiber sliding relative to the matrix in the interface debonded region. The relationships between the fatigue hysteresis loops, fatigue hysteresis dissipated energy, fatigue peak stress, matrix multiple cracking modes, and interface shear stress have been established. The effects of fiber volume fraction, fatigue peak stress and matrix cracking mode proportion on fatigue hysteresis dissipated energy and interface debonding and sliding have been analyzed. The experimental fatigue hysteresis dissipated energy of 2D C/SiC and SiC/SiC composites at room temperature, 550 °C, 800 °C, and 1100 °C in air, and 1200 °C in vacuum corresponding to different fatigue peak stresses and cycle numbers have been analyzed. The interface shear stress degradation rate has been obtained through comparing the experimental fatigue hysteresis dissipated energy with theoretical values. Fatigue damage evolution in C/SiC and SiC/SiC composites has been compared using damage parameters of fatigue hysteresis dissipated energy and interface shear stress degradation rate. It was found that the interface shear stress degradation rate increases at elevated temperature in air compared with that at room temperature, decreases with increasing loading frequency at room temperature, and increases with increasing fatigue peak stress at room and elevated temperatures. PMID:28773966

The Status of Business Communication Technology: A Bibliography.

ERIC Educational Resources Information Center

Williams, Al; Ross, Dianne

1992-01-01

Provides a bibliography of 79 articles on technology and communication from the following sources: "ABI/Inform,""Academic Abstracts,""ERIC,""UMI's Dissertation Abstracts,""Wilson's Applied Science and Technology Index" and "Wilson's Education Index" (1986 through 1991); the "Journal…

VIEW FROM THE GENERATOR FLOOR LOOKING DOWN AT THE SPIRAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW FROM THE GENERATOR FLOOR LOOKING DOWN AT THE SPIRAL DISTRIBUTOR AND DRAFT CONE. - Wilson Dam & Hydroelectric Plant, Turbine & Generator Unit, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

VIEW FROM DRAFT TUBE LOOKING UP TOWARDS THE GENERATOR FLOOR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW FROM DRAFT TUBE LOOKING UP TOWARDS THE GENERATOR FLOOR, DRAFT CONE IN FOREGROUND. - Wilson Dam & Hydroelectric Plant, Turbine & Generator Unit, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

20. GENERAL VIEW OF CONSTRUCTION LOOKING NORTHEAST SHOWING THE CONSTRUCTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. GENERAL VIEW OF CONSTRUCTION LOOKING NORTHEAST SHOWING THE CONSTRUCTION BRIDGE, GANTRY CRANE AND STRUCTURAL PIERS. - Wilson Dam & Hydroelectric Plant, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

Wilson's disease: the 60th anniversary of Walshe's article on treatment with penicillamine.

PubMed

Teive, Hélio A G; Barbosa, Egberto Reis; Lees, Andrew J

2017-01-01

This historical review describes Professor Walshe's seminal contribution to the treatment of Wilson's disease on the 60th anniversary of his pioneering article on penicillamine, the first effective treatment for the condition.

CLOSEUP VIEW OF A GENERATOR UNIT WITH ITS ASSOCIATED INSTRUMENTATION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CLOSE-UP VIEW OF A GENERATOR UNIT WITH ITS ASSOCIATED INSTRUMENTATION AND CONTROL PANEL. - Wilson Dam & Hydroelectric Plant, Turbine & Generator Unit, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

Wilson in Node 1 Unity

NASA Image and Video Library

2010-04-10

S131-E-008502 (10 April 2010) --- NASA astronaut Stephanie Wilson, STS-131 mission specialist, retrieves a tool from a drawer in the Unity node of the International Space Station while space shuttle Discovery remains docked with the station.

Genetics Home Reference: Wilson disease

MedlinePlus

... individuals diagnosed in adulthood and commonly occur in young adults with Wilson disease . Signs and symptoms of these problems can include clumsiness, tremors, difficulty walking, speech problems, impaired thinking ability, depression, anxiety, and mood swings. In many individuals with ...

Atypical presentation of Wilson disease.

PubMed

Wadera, Sheetal; Magid, Margret S; McOmber, Mark; Carpentieri, David; Miloh, Tamir

2011-08-01

A 15-year-old Caucasian female on human chorionic gonadotropin (HCG) diet presented with fever, cholestasis, coagulopathy, hemolytic anemia, and acute renal dysfunction. Imaging of the biliary system and liver were normal. She responded to intravenous antibiotics, vitamin K and blood transfusions but experienced relapse upon discontinuation of antibiotics. She had remission with reinstitution of antibiotics. Liver biopsy revealed pronounced bile ductular reaction, bridging fibrosis, and hepatocytic anisocytosis and anisonucleosis with degenerative enlarged eosinophilic hepatocytes, suggestive of Wilson disease. Diagnosis of Wilson disease was further established based on the low serum ceruloplasmin, increased urinary and hepatic copper and presence of Kayser-Fleischer rings. The multisystem involvement of the liver, kidney, blood, and brain are consistent with Wilson disease; however, the clinical presentation of cholangitis and reversible coagulopathy is uncommon, and may result from concurrent acute cholangitis and/or the HCG diet regimen the patient was on. © Thieme Medical Publishers.

Lifting q-difference operators for Askey-Wilson polynomials and their weight function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Atakishiyeva, M. K.; Atakishiyev, N. M., E-mail: natig_atakishiyev@hotmail.com

2011-06-15

We determine an explicit form of a q-difference operator that transforms the continuous q-Hermite polynomials H{sub n}(x | q) of Rogers into the Askey-Wilson polynomials p{sub n}(x; a, b, c, d | q) on the top level in the Askey q-scheme. This operator represents a special convolution-type product of four one-parameter q-difference operators of the form {epsilon}{sub q}(c{sub q}D{sub q}) (where c{sub q} are some constants), defined as Exton's q-exponential function {epsilon}{sub q}(z) in terms of the Askey-Wilson divided q-difference operator D{sub q}. We also determine another q-difference operator that lifts the orthogonality weight function for the continuous q-Hermite polynomialsH{submore » n}(x | q) up to the weight function, associated with the Askey-Wilson polynomials p{sub n}(x; a, b, c, d | q).« less

Chern-Simons theory with Wilson lines and boundary in the BV-BFV formalism

NASA Astrophysics Data System (ADS)

Alekseev, Anton; Barmaz, Yves; Mnev, Pavel

2013-05-01

We consider the Chern-Simons theory with Wilson lines in 3D and in 1D in the BV-BFV formalism of Cattaneo-Mnev-Reshetikhin. In particular, we allow for Wilson lines to end on the boundary of the space-time manifold. In the toy model of 1D Chern-Simons theory, the quantized BFV boundary action coincides with the Kostant cubic Dirac operator which plays an important role in representation theory. In the case of 3D Chern-Simons theory, the boundary action turns out to be the odd (degree 1) version of the BF model with source terms for the B field at the points where the Wilson lines meet the boundary. The boundary space of states arising as the cohomology of the quantized BFV action coincides with the space of conformal blocks of the corresponding WZW model.

Modeling of a viscoelastic damper and its application in structural control.

PubMed

Mehrabi, M H; Suhatril, Meldi; Ibrahim, Zainah; Ghodsi, S S; Khatibi, Hamed

2017-01-01

Conventional seismic rehabilitation methods may not be suitable for some buildings owing to their high cost and time-consuming foundation work. In recent years, viscoelastic dampers (VEDs) have been widely used in many mid- and high-rise buildings. This study introduces a viscoelastic passive control system called rotary rubber braced damper (RRBD). The RRBD is an economical, lightweight, and easy-to-assemble device. A finite element model considering nonlinearity, large deformation, and material damage is developed to conduct a parametric study on different damper sizes under pushover cyclic loading. The fundamental characteristics of this VED system are clarified by analyzing building structures under cyclic loading. The result show excellent energy absorption and stable hysteresis loops in all specimens. Additionally, by using a sinusoidal shaking table test, the effectiveness of the RRBD to manage the response displacement and acceleration of steel frames is considered. The RRBD functioned at early stages of lateral displacement, indicating that the system is effective for all levels of vibration. Moreover, the proposed damper shows significantly better performance in terms of the column compression force resulting from the brace action compared to chevron bracing (CB).

Automated extraction and classification of RNA tertiary structure cyclic motifs

PubMed Central

Lemieux, Sébastien; Major, François

2006-01-01

A minimum cycle basis of the tertiary structure of a large ribosomal subunit (LSU) X-ray crystal structure was analyzed. Most cycles are small, as they are composed of 3- to 5 nt, and repeated across the LSU tertiary structure. We used hierarchical clustering to quantify and classify the 4 nt cycles. One class is defined by the GNRA tetraloop motif. The inspection of the GNRA class revealed peculiar instances in sequence. First is the presence of UA, CA, UC and CC base pairs that substitute the usual sheared GA base pair. Second is the revelation of GNR(Xn)A tetraloops, where Xn is bulged out of the classical GNRA structure, and of GN/RA formed by the two strands of interior-loops. We were able to unambiguously characterize the cycle classes using base stacking and base pairing annotations. The cycles identified correspond to small and cyclic motifs that compose most of the LSU RNA tertiary structure and contribute to its thermodynamic stability. Consequently, the RNA minimum cycles could well be used as the basic elements of RNA tertiary structure prediction methods. PMID:16679452

The multiaxial fatigue response of cylindrical geometry under proportional loading subject to fluctuating tractions

NASA Astrophysics Data System (ADS)

Martinez, Rudy D.

A multiaxial fatigue model is proposed, as it would apply to cylindrical geometry in the form of industrial sized pressure vessels. The main focus of the multiaxial fatigue model will be based on using energy methods with the loading states confined to fluctuating tractions under proportional loading. The proposed fatigue model is an effort to support and enhance existing fatigue life predicting methods for pressure vessel design, beyond the ASME Boiler and Pressure Vessel codes, ASME Section VIII Division 2 and 3, which is currently used in industrial engineering practice for pressure vessel design. Both uniaxial and biaxial low alloy pearlittic-ferritic steel cylindrical cyclic test data are utilized to substantiate the proposed fatigue model. Approximate material hardening and softening aspects from applied load cycling states and the Bauschinger effect are accounted for by adjusting strain control generated hysteresis loops and the cyclic stress strain curve. The proposed fatigue energy model and the current ASME fatigue model are then compared with regards to the accuracy of predicting fatigue life cycle consistencies.

Development of constitutive models for cyclic plasticity and creep behavior of super alloys at high temperature

NASA Technical Reports Server (NTRS)

Haisler, W. E.

1983-01-01

An uncoupled constitutive model for predicting the transient response of thermal and rate dependent, inelastic material behavior was developed. The uncoupled model assumes that there is a temperature below which the total strain consists essentially of elastic and rate insensitive inelastic strains only. Above this temperature, the rate dependent inelastic strain (creep) dominates. The rate insensitive inelastic strain component is modelled in an incremental form with a yield function, blow rule and hardening law. Revisions to the hardening rule permit the model to predict temperature-dependent kinematic-isotropic hardening behavior, cyclic saturation, asymmetric stress-strain response upon stress reversal, and variable Bauschinger effect. The rate dependent inelastic strain component is modelled using a rate equation in terms of back stress, drag stress and exponent n as functions of temperature and strain. A sequence of hysteresis loops and relaxation tests are utilized to define the rate dependent inelastic strain rate. Evaluation of the model has been performed by comparison with experiments involving various thermal and mechanical load histories on 5086 aluminum alloy, 304 stainless steel and Hastelloy X.

Greg Wilson, D.Sc. | NREL

Science.gov Websites

Chemical Engineering from Washington University in St. Louis and a B.S. in Chemical Engineering from the Number 6,284,384. Gregory M. Wilson, et al., "Pressure Equalization System for Chemical Vapor

76 FR 17862 - Ocean Transportation Intermediary License; Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

..., President/Secretary, (Qualifying Individual), Application Type: New OFF License. Wilson Transportation, Inc. (OFF), 16226 Foster Street, Overland Park, KS 66085, Officers: Jerry G. Owen, Vice President International, (Qualifying Individual), Mark A. Wilson, President/Treasurer/Secretary, Application Type: New OFF...

Fermilab Today

Science.gov Websites

Wilson Cluster; First Light in T-1007 Prototype Optical Cavity for Holometer/Axions Tuesday, May 3 3:30 Mieland, Fermilab ES&H, and will take place from noon to 12:45 p.m. on Tuesday, May 3, in Wilson Hall

View in the Woodrow Wilson Plaza (along the building's 13th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View in the Woodrow Wilson Plaza (along the building's 13th Street side) looking to Martin Puryear's "Bearing Witness" sculpture - Ronald Reagan Building and International Trade Center, 1300 Pennsylvania Avenue, NW, Washington, District of Columbia, DC

VIEW LOOKING SOUTHEAST AT ROUTE 133, SHOWING A CORNER DETAIL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW LOOKING SOUTHEAST AT ROUTE 133, SHOWING A CORNER DETAIL OF THE POWERHOUSE AND A SECTION OF THE SWITCHYARD. - Wilson Dam & Hydroelectric Plant, Spanning Tennessee River at Wilson Dam Road (Route 133), Muscle Shoals, Colbert County, AL

78 FR 51736 - Notice of FY 2013 Refugee Targeted Assistance Formula Awards to States and Wilson/Fish...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

...The Office of Refugee Resettlement (ORR), Administration for Children and Families (ACF), announces the allocation of Refugee Targeted Assistance formula awards to States and Wilson/Fish Alternative Project grantees.

Wilson at RWS for STS-131 EVA 3 SSRMS Support

NASA Image and Video Library

2010-04-13

View of Stephanie Wilson as she works at the Robotics Workstation (RWS) in US Laboratory Destiny as she conducts a Space Station Remote Manipulator System (SSRMS) Ammonia Tank Assembly (ATA) retrieval in support of STS-131 EVA 3.

Wilson on the AFD during STS-121

NASA Image and Video Library

2006-07-05

S121-E-05438 (5 July 2006) --- Astronaut Stephanie D. Wilson, STS-121 mission specialist, on Discovery's flight deck during flight day two activities, on the eve of one of the mission's busiest days -- docking day with the International Space Station.

Truck shipments across the Woodrow Wilson Bridge : value and tonnage in 1993

DOT National Transportation Integrated Search

1998-04-01

The Woodrow Wilson Bridge, where Interstate 95 crosses the Potomac River just south of Washington, DC, carries significant amounts of freight to support economic activities well beyond the nation's capitol. The Bureau of Transportation Statistics (BT...

Heterogeneous Multi-Robot Cooperation

DTIC Science & Technology

1994-02-01

1992a) Maja Mataric. Designing emergent behaviors: From local interac- tions to collective intelligence. In J. Meyer, H. Roitblat , and S. Wilson, editors...1992] Lynne E. Parker. Adaptive action selection for cooperative agent teams. In Jean-Arcady Meyer, Herbert Roitblat . and Stewart Wilson. editors

Test and Evaluation for Chemical Resistance of Gloves Worn for Protection against Exposure to H-70 Hydrazine.

DTIC Science & Technology

1980-07-01

Edmont-Wilson 37-165 NBR .056 (22) 10 J Edmont-Wilson 26-665 Rubber .046 (18) 10 K Edmont-Wilson 36-755 Rubber .102 (40) 10 L Surety 10-112L Nitrile...4367 Dickenson & Company Charleston SC 29405 Coshocton OH 43812 International Playtex Company Surety Rubber Company Industrial Gloves Division P.O. Box...B Pioneer A-10 Nitrile .025 (10) 9 C Pioneer A-15 Nitrile .038 (15) 9 D Norton NSN 8415-00-753-6551 Butyl rubber .076 (30) M E Norton NSN 8415-01-025

The level of serum lipids, vitamin E and low density lipoprotein oxidation in Wilson's disease patients.

PubMed

Rodo, M; Czonkowska, A; Pulawska, M; Swiderska, M; Tarnacka, B; Wehr, H

2000-09-01

The aim of this study was to estimate the level of lipids and of the main serum antioxidant, alpha-tocopherol (vitamin E), and to evaluate the susceptibility of low density lipoprotein (LDL) to oxidation in Wilson's disease patients. It was assumed that enhanced LDL peroxidation caused by high copper levels could contribute to the injury of liver and other tissues. The group investigated comprised 45 individuals with Wilson's disease treated with penicillamine or zinc salts and a control group of 36 healthy individuals. Lipids were determined by enzymatic methods, alpha-tocopherol by high performance liquid chromatography, the susceptibility of LDL to oxidation in vitro by absorption changes at 234 nm during 5 h and end-products of LDL lipid oxidation as thiobarbituric acid reacting substances. In Wilson's disease patients total cholesterol, LDL cholesterol and alpha-tocopherol levels were significantly lower compared with the control group. No difference in LDL oxidation in vitro between the patients and the controls was stated. enhanced susceptibility of isolated LDL for lipid peroxidation in vitro was not observed in Wilson's disease patients. One cannot exclude, however, that because of low alpha-tocopherol level lipid peroxidation in the tissues can play a role in the pathogenesis of tissue injury in this disease.

Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oe, Shinji, E-mail: ooes@med.uoeh-u.ac.jp; Miyagawa, Koichiro, E-mail: koichiro@med.uoeh-u.ac.jp; Honma, Yuichi, E-mail: y-homma@med.uoeh-u.ac.jp

Copper is an essential trace element, however, excess copper is harmful to human health. Excess copper-derived oxidants contribute to the progression of Wilson disease, and oxidative stress induces accumulation of abnormal proteins. It is known that the endoplasmic reticulum (ER) plays an important role in proper protein folding, and that accumulation of misfolded proteins disturbs ER homeostasis resulting in ER stress. However, copper-induced ER homeostasis disturbance has not been fully clarified. We treated human hepatoma cell line (Huh7) and immortalized-human hepatocyte cell line (OUMS29) with copper and chemical chaperones, including 4-phenylbutyrate and ursodeoxycholic acid. We examined copper-induced oxidative stress, ERmore » stress and apoptosis by immunofluorescence microscopy and immunoblot analyses. Furthermore, we examined the effects of copper on carcinogenesis. Excess copper induced not only oxidative stress but also ER stress. Furthermore, excess copper induced DNA damage and reduced cell proliferation. Chemical chaperones reduced this copper-induced hepatotoxicity. Excess copper induced hepatotoxicity via ER stress. We also confirmed the abnormality of ultra-structure of the ER of hepatocytes in patients with Wilson disease. These findings show that ER stress plays a pivotal role in Wilson disease, and suggests that chemical chaperones may have beneficial effects in the treatment of Wilson disease.« less

Crystal structure of four-stranded Oxytricha telomeric DNA

NASA Technical Reports Server (NTRS)

Kang, C.; Zhang, X.; Ratliff, R.; Moyzis, R.; Rich, A.

1992-01-01

The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.

Wilson Campus School, 1968-77.

ERIC Educational Resources Information Center

Long, Kathleen M.

1994-01-01

Describes an open-format laboratory school housed on the campus of Manakato University in Minnesota that was the antithesis of dominant schooling patterns in 1968. Wilson Campus School practiced early forms of authentic assessment, participative decision making, cooperative learning, nongraded student grouping, multicultural education, and…

Wilsonline.

ERIC Educational Resources Information Center

Nitecki, Danuta A.

1985-01-01

Observations on impact of WILSONLINE (online access to H. W. Wilson's indexes) on the industry, library services, and end users are drawn from interviews with reference librarians, H. W. Wilson administrative staff, and monitors of database industry. Issues addressed include quality, thoroughness, ease of use, and marketing (demand, pricing,…

The Mount Wilson-University of California Connection from Hussey and Seares to Mayall and Olin Wilson

NASA Astrophysics Data System (ADS)

Osterbrock, D. E.

2004-12-01

George Ellery Hale, who founded Mount Wilson Solar Observatory, first visited Lick Observatory in 1890, soon after his graduation from MIT. After his parents' deaths, when he began openly planning a Yerkes Observatory ``expedition" to California, Hale's friend James E. Keeler, then Lick Observatory Director, invited him (in 1899) to locate it on Mt.Hamilton. Hale thanked him, but replied that sites further south would have more clear weather. He had probably already decided on Mount Wilson. There were many close connections between the University of California and Mount Wilson Observatory from that time right up to the present. W.J. Hussey was the Lick astronomer who carried out the official site survey that confirmed Mount Wilson as the best site. Harold Palmer (UC Astronomy PhD 1903) was the first new staff member Hale hired, but he only lasted a few months. The two main reasons for the continuing connection were the geographical proximity of Pasadena and the Bay Area, and the fact that for many years UC was the outstanding graduate astronomy department in the country, producing numerous well trained observational research astronomers. However in the early years the reasons were more complicated. After Palmer, the next three hired at MWO were Arthur King, the first UC Physics PhD (1903); Harold Babcock, (UC Engineering BS 1907); and F.H. Seares (UC Astronomy BS 1895). Harold Babcock trained his son in astronomy almost from birth, and Horace (UC Astronomy PhD 1938) joined the MWO staff after World War II and became its Director in 1964. Palmer and Edward Fath (UC PhD 1909) were less successful at MWO and soon departed. These and numerous other MWO astronomers with UC backgrounds will be mentioned, and their careers discussed.

Analysis of the curve of Spee and the curve of Wilson in adult Indian population: A three-dimensional measurement study.

PubMed

Surendran, Sowmya Velekkatt; Hussain, Sharmila; Bhoominthan, S; Nayar, Sanjna; Jayesh, Ragavendra

2016-01-01

When reconstructing the occlusal curvatures dentists often use a 4-inch radii arc as a rough standard based on Monson spherical theory. The use of an identical radius for the curve of Spee for all patients may not be appropriate because each patient is individually different. The validity of application of this theory in the Indian population and the present study has been undertaken. This study is an attempt to evaluate the curve of Spee and curve of Wilson in young Indian population using three dimensional analysis. This study compared the radius and the depth of right and left, maxillary and mandibular curves of Spee and the radius of maxillary and mandibular curves of Wilson in males and females. The cusp tips of canines, buccal cusp tips of premolars and molars and palatal/lingual cusp tips of second molars of 60 maxillary and 60 mandibular casts were obtained. Three-dimensional (x, y, z) coordinates of the cusp tips of the molars, premolars, and canines of the right and left sides of the maxilla and mandible were obtained with three dimensional coordinate measuring machine. The radius and the depth of right and left, maxillary and mandibular curves of Spee and the radius of maxillary and mandibular curves of Wilson were measured by means of computer software Metrologic-XG. Pearson's correlation test and Independent t-test were used to test the statistical significance (α=.05). The values of curve of Spee and curve of Wilson in Indian population obtained from this study were higher than the 4 inch (100 mm) radius proposed by Monson. These findings suggest ethnic differences in the radius of curve of Spee and curve of Wilson.

Presence of the p.L456V polymorphism in Cuban patients clinically diagnosed with Wilson's disease.

PubMed

Clark-Feoktistova, Y; Ruenes-Domech, C; García-Bacallao, E F; Roblejo-Balbuena, H; Feoktistova, L; Clark-Feoktistova, I; Jay-Herrera, O; Collazo-Mesa, T

2018-06-10

Wilson's disease is characterized by the accumulation of copper in different organs, mainly affecting the liver, brain, and cornea, and is caused by mutations in the ATP7B gene. More than 120 polymorphisms in the ATP7B gene have been reported in the medical literature. The aim of the present study was to identify the conformational changes in the exon 3 region of the ATP7B gene and detect the p.L456V polymorphism in Cuban patients clinically diagnosed with Wilson's disease. A descriptive study was conducted at the Centro Nacional de Genética Médica and the Instituto Nacional de Gastroenterología within the time frame of 2007-2012 and included 105 patients with a clinical diagnosis of Wilson's disease. DNA extraction was performed through the salting-out method and the fragment of interest was amplified using the polymerase chain reaction technique. The conformational shift changes in the exon 3 region and the presence of the p.L456V polymorphism were identified through the Single-Strand Conformation Polymorphism analysis. The so-called b and c conformational shift changes, corresponding to the p.L456V polymorphism in the heterozygous and homozygous states, respectively, were identified. The allelic frequency of the p.L456V polymorphism in the 105 Cuban patients that had a clinical diagnosis of Wilson's disease was 41% and liver-related symptoms were the most frequent in the patients with that polymorphism. The p.L456V polymorphism was identified in 64 Cuban patients clinically diagnosed with Wilson's disease, making future molecular study through indirect methods possible. Copyright © 2018 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.

A study of microstructure, quasi-static response, fatigue, deformation and fracture behavior of high strength alloy steels

NASA Astrophysics Data System (ADS)

Kannan, Manigandan

The history of steel dates back to the 17th century and has been instrumental in the betterment of every aspect of our lives ever since, from the pin that holds the paper together to the Automobile that takes us to our destination steel touches everyone every day. Path breaking improvements in manufacturing techniques, access to advanced machinery and understanding of factors like heat treatment, corrosion resistance have aided in the advancement in the properties of steel in the last few years. In this dissertation document, the results of a study aimed at the influence of alloy chemistry, processing and influence of the quasi static and fatigue behavior of seven alloy steels is discussed. The microstructure of the as-received steel was examined and characterized for the nature and morphology of the grains and the presence of other intrinsic features in the microstructure. The tensile, cyclic fatigue and bending fatigue tests were done on a fully automated closed-loop servo-hydraulic test machine at room temperature. The failed samples of high strength steels were examined in a scanning electron microscope for understanding the fracture behavior, especially the nature of loading be it quasi static, cyclic fatigue or bending fatigue . The quasi static and cyclic fatigue fracture behavior of the steels examined coupled with various factors contributing to failure are briefly discussed in light of the conjoint and mutually interactive influences of intrinsic microstructural effects, nature of loading, and stress (load)-deformation-microstructural interactions.

78 FR 73559 - Moose-Wilson Corridor Comprehensive Management Plan, Environmental Impact Statement, Grand Teton...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

...-Wilson Corridor Comprehensive Management Plan, Environmental Impact Statement, Grand Teton National Park... is preparing a Comprehensive Management Plan and Environmental Impact Statement (EIS) for the Moose...; (2) distinguish the corridor's fundamental and other important resources and values; (3) clearly...

Decision for the Draft.

ERIC Educational Resources Information Center

Chambers, John Whiteclay, II

2002-01-01

Discusses why U.S. President Woodrow Wilson decided to institute the military draft. Provides background information on when Wilson changed from insisting on using volunteers in the military to his resolve for instituting the draft, due to a challenge of power by former U.S. President Theodore Roosevelt. (CMK)

[Wilson disease. A case report and review of the literature].

PubMed

Alva-Moncayo, Edith; Castro-Tarín, María; González-Serrano, Adolfo

2011-01-01

Wilson disease is a problem of cuprum metabolism, with recesive autosomic hereditary transmission and a prevalence of one in 30,000 habitants. The cuprum is deposit in a progressive and irreversible way in the liver and encephalus and it is not liberated with quelant treatment. Neurological manifestations are tremor, disartria, extrapiramidal manifestations or distonia. Ophthalmic exploration shows corneal limb with sign of Kayser-Fleischer. a 15-year-old masculine patient with previous hepatitis outbreak in two times. During the last year he presented distonia, bradicinecious, stiffness and indifference with ictericia. Ophthalmological examination reported Kayser-Fleisher rings. Magnetic resonance of brain showed high dense images in lenticular, pallidus globe and caudate nucleus suggestive of Wilson disease. Ceruloplasmin concentration, cuprum in the liver biopsy confirmed the diagnosis. the importance of the case was the hepatic initial manifestations and two years after presented with inexpressive face, and it was considered a psychiatric disease, but the neurological evaluation and the liver biopsy confirmed the diagnosis of Wilson disease.

The Observatory as Laboratory: Spectral Analysis at Mount Wilson Observatory

NASA Astrophysics Data System (ADS)

Brashear, Ronald

2018-01-01

This paper will discuss the seminal changes in astronomical research practices made at the Mount Wilson Observatory in the early twentieth century by George Ellery Hale and his staff. Hale’s desire to set the agenda for solar and stellar astronomical research is often described in terms of his new telescopes, primarily the solar tower observatories and the 60- and 100-inch telescopes on Mount Wilson. This paper will focus more on the ancillary but no less critical parts of Hale’s research mission: the establishment of associated “physical” laboratories as part of the observatory complex where observational spectral data could be quickly compared with spectra obtained using specialized laboratory equipment. Hale built a spectroscopic laboratory on the mountain and a more elaborate physical laboratory in Pasadena and staffed it with highly trained physicists, not classically trained astronomers. The success of Hale’s vision for an astronomical observatory quickly made the Carnegie Institution’s Mount Wilson Observatory one of the most important astrophysical research centers in the world.

Characterization of Runella slithyformis HD-Pnk, a Bifunctional DNA/RNA End-Healing Enzyme Composed of an N-Terminal 2′,3′-Phosphoesterase HD Domain and a C-Terminal 5′-OH Polynucleotide Kinase Domain

PubMed Central

Munir, Annum

2016-01-01

ABSTRACT 5′- and 3′-end-healing reactions are key steps in nucleic acid break repair in which 5′-OH ends are phosphorylated by a polynucleotide kinase (Pnk) and 3′-PO4 or 2′,3′-cyclic-PO4 ends are hydrolyzed by a phosphoesterase to generate the 5′-PO4 and 3′-OH termini required for sealing by classic polynucleotide ligases. End-healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex. Here we identify and characterize Runella slithyformis HD-Pnk as a novel bifunctional end-healing enzyme composed of an N-terminal 2′,3′-phosphoesterase HD domain and a C-terminal 5′-OH polynucleotide kinase P-loop domain. HD-Pnk phosphorylates 5′-OH polynucleotides (9-mers or longer) in the presence of magnesium and any nucleoside triphosphate donor. HD-Pnk dephosphorylates RNA 2′,3′-cyclic phosphate, RNA 3′-phosphate, RNA 2′-phosphate, and DNA 3′-phosphate ends in the presence of a transition metal cofactor, which can be nickel, copper, or cobalt. HD-Pnk homologs are present in genera from 11 bacterial phyla and are often encoded in an operon with a putative ATP-dependent polynucleotide ligase. IMPORTANCE The present study provides insights regarding the diversity of nucleic acid repair strategies via the characterization of Runella slithyformis HD-Pnk as the exemplar of a novel clade of dual 5′- and 3′-end-healing enzymes that phosphorylate 5′-OH termini and dephosphorylate 2′,3′-cyclic-PO4, 3′-PO4, and 2′-PO4 ends. The distinctive feature of HD-Pnk is its domain composition, i.e., a fusion of an N-terminal HD phosphohydrolase module and a C-terminal P-loop polynucleotide kinase module. Homologs of Runella HD-Pnk with the same domain composition, same domain order, and similar polypeptide sizes are distributed widely among genera from 11 bacterial phyla. PMID:27895092

An unconventional route to becoming a cell biologist

PubMed Central

Fuchs, Elaine

2015-01-01

I am honored to be the E. B. Wilson Award recipient for 2015. As we know, it was E. B. Wilson who popularized the concept of a “stem cell” in his book The Cell in Development and Inheritance (1896, London: Macmillan & Co.). Given that stem cell research is my field and that E. B. Wilson is so revered within the cell biology community, I am a bit humbled by how long it took me to truly grasp his vision and imaginative thinking. I appreciate it deeply now, and on this meaningful occasion, I will sketch my rather circuitous road to cell biology. PMID:26515974

Notes on winter feeding behavior and molt in Wilson's phalaropes

USGS Publications Warehouse

Burger, J.; Howe, M.

1975-01-01

Wilson's Phalaropes, Steganopus tricolor, migrate in late summer from the prairie regions of North America to their wintering grounds in the highlands of Peru and the inland and coastal waters of Chile, Bolivia, Paraguay, Uruguay, and Argentina (Holmes 1939, Meyer de Schauensee 1970). Reports on these birds from their wintering habitat are few. This paper describes numbers, feeding behavior, and molt of Wilson's Phalaropes wintering in a freshwater marsh in central Argentina. Fieldwork in Argentina was conducted by the senior author. The junior author analyzed molt patterns of birds collected there and added data he collected in North Dakota in 1968 and 1969.

A history of altruism focusing on Darwin, Allee and E.O. Wilson.

PubMed

Domondon, Andrew T

2013-06-01

The problem of altruism refers to the apparent difficulty in reconciling the existence of altruists, individuals who reduce their own fitness to increase the fitness of others, with natural selection. A historical and philosophical overview of solutions to this apparent contradiction is presented through a close reading of the key texts of Charles Darwin, Warder C. Allee and Edward O. Wilson. Following an analysis of Darwin's explanation for altruism, I examine the ideas of group selection and kin selection advanced by Allee and Wilson, respectively, Attention is also given to the philosophical implications each associated with their respective solutions. Copyright © 2013 Elsevier Ltd. All rights reserved.

William E. Wilson and his contemporaries

NASA Astrophysics Data System (ADS)

Elliott, I.

Although he never attended school or university, William E. Wilson FRS, of Daramona, County Westmeath, made pioneering contributions to solar physics, celestial photography and stellar photometry. His well-equipped observatory attracted collaborators who included George Francis FitzGerald of Trinity College Dublin and Arthur Rambaut of Dunsink Observatory.

76 FR 13992 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... result in a contrary determination. ADDRESSES: You may submit comments, identified by docket number and... ``Deputy Director, Defense Manpower Data Center, 1600 Wilson Boulevard, Suite 400, Arlington, VA 22209... Deputy Director, Defense Manpower Data Center, 1600 Wilson Boulevard, Suite 400, Arlington, VA 22209-2593...

Material investigation of the full-depth, precast concrete deck panels of the old Woodrow Wilson Bridge.

DOT National Transportation Integrated Search

2007-01-01

The Woodrow Wilson Memorial Bridge crossing the Potomac River near Washington, D.C., was replaced after more than 45 years of service. Researchers examined the full-depth, precast lightweight concrete deck panels that were installed on this structure...

Robert Wilson's Invitation to Insanity.

ERIC Educational Resources Information Center

Stephens, Judith L.

The plays of stage director Robert Wilson are devices presenting alternative modes of perception to theatre audiences accustomed to verbal/aural structures of experience. Uniting his interests in the arts and therapy, his plays create a theatrical event promoting empathy with the perceptions of the mentally or physically handicapped and…

College Board Response to "Harvard Educational Review" Article by Santelices and Wilson

ERIC Educational Resources Information Center

College Board, 2010

2010-01-01

This is the College Board's response to a research article by Drs. Maria Veronica Santelices and Mark Wilson in the Harvard Educational Review, entitled "Unfair Treatment? The Case of Freedle, the SAT, and the Standardization Approach to Differential Item Functioning" (see EJ930622).

Multicycle study on chemical-looping combustion of simulated coal gas with a CaSO{sub 4} oxygen carrier in a fluidized bed reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qilei Song; Rui Xiao; Zhongyi Deng

2008-11-15

The cyclic test of a CaSO{sub 4}-based oxygen carrier (natural anhydrite) in alternating reducing simulated coal gas and oxidizing conditions was performed at 950{degree}C in a fluidized bed reactor at atmospheric pressure. A high concentration of CO{sub 2} was obtained in the reduction. The H{sub 2} and CO conversions and CO{sub 2} yield increased initially and final decreased significantly. The release of SO{sub 2} and H{sub 2}S during the cyclic test was found to be responsible for the decrease of reactivity of a CaSO{sub 4} oxygen carrier. The oxygen carrier conversion after the reduction reaction decreased gradually in the cyclicmore » test. Through the comparison of mass-based reaction rates as a function of mass conversion at typical cycles, it was also evident that the reactivity of a CaSO{sub 4} oxygen carrier increased for the initial cycles but finally decreased after around 15 cycles. X-ray diffraction analysis revealed that the presence and intensity of the reduction sulfur species was in accordance with the results of gas conversion. The content of CaO was higher than expected, suggesting the formation of SO{sub 2} and H{sub 2}S during the cycles. Surface morphology analysis demonstrates that the natural anhydrite particle surface varied from impervious to porous after the cyclic test. It was also observed that the small grains on the surface of the oxygen carrier sintered in the cyclic tests. Energy-dispersive spectrum analysis also demonstrated the decrease of oxygen intensity after reduction, and CaO became the main component after the 20th oxidation. Pore structure analysis suggested that the particles agglomerated or sintered in the cyclic tests. The possible method for sulfur mitigation is proposed. Finally, some basic consideration on the design criteria of a CLC system for solid fuels using a CaSO{sub 4} oxygen carrier is discussed by the references and provides direction for future work. 49 refs., 10 figs., 5 tabs.« less

Epidemiology and introduction to the clinical presentation of Wilson disease.

PubMed

Lo, Christine; Bandmann, Oliver

2017-01-01

Our understanding of the epidemiology of Wilson disease has steadily grown since Sternlieb and Scheinberg's first prevalence estimate of 5 per million individuals in 1968. Increasingly sophisticated genetic techniques have led to revised genetic prevalence estimates of 142 per million. Various population isolates exist where the prevalence of Wilson disease is higher still, the highest being 885 per million from within the mountainous region of Rucar in Romania. In Sardinia, where the prevalence of Wilson disease has been calculated at 370 per million births, six mutations account for around 85% of Wilson disease chromosomes identified. Significant variation in the patterns of presentation may however exist, even between individuals carrying the same mutations. At either extremes of presentation are an 8-month-old infant with abnormal liver function tests and individuals diagnosed in their eighth decade of life. Three main patterns of presentation have been recognized - hepatic, neurologic, and psychiatric - prompting their presentation to a diverse range of specialists. Deviations in the family history from the anticipated autosomal-recessive mode of inheritance, with apparent "pseudodominance" and mechanisms of inheritance that include uniparental isodisomy (the inheritance of both chromosomal copies from a single parent), may all further cloud the diagnosis. It can therefore take the efforts of an astute clinician with a high clinical index of suspicion to clinch the diagnosis of this eminently treatable condition. © 2017 Elsevier B.V. All rights reserved.

Search for Activity in Comet-Asteroid Transition Object 107P/Wilson-Harrington

NASA Astrophysics Data System (ADS)

Khayat, Alain; Meech, K.; Pittichova, J.; Schorghofer, N.; Yang, B.; Sonnett, S.; Riesen, T.; Kleyna, J.; Kaluna, H.; Keane, J.

2010-10-01

Comet-asteroid transition object 107P/Wilson-Harrington was observed near its October 22, 2009 perihelion passage to search for activity. No activity was detected. Consequently, we place limits on possible dust production of 0.013 kg/s at 1.23 AU. Furthermore, the data was not sufficient to constrain a rotation period; however, it is clear that the rotation period is > 4hr. Our data is consistent with the observations of others (6.1 hr). Phase function fitting yielded a value of the phase coefficient beta= 0.0406 ± .0001 mag/deg, similar to C-type asteroids that have a linear phase curve at large phase angles. Thermal models for 107P/Wilson-Harrington show that the average loss rate of exposed crystalline ice at zero latitude is in the order of 0.3 meters/year. The derived high loss rate suggests that 107P/Wilson-Harrington is deprived of surface ice. Our observations and analysis confirm earlier findings that 107P/Wilson-Harrington is an example of the very few such objects discovered so far. Such study we made is a critical next step in understanding the life of dormant comets, and a window into the evolutionary end states of the lives of comets that become extinct. This work has been supported in part by AST-0807521 from the National Science Foundation.

Sociobiology for Social Scientists: A Critical Introduction to E.O. Wilson's Evolutionary Paradigm.

ERIC Educational Resources Information Center

Dugger, William M.

1981-01-01

Reviews recent works of E.O. Wilson on sociobiology (the evolutionary and comparative study of social animals, including humans). Topics discussed include the nature of sociobiology, explanatory hypotheses in sociobiology, subdisciplines, biological individualism and altruism, costs of social engineering, and evolutionary perspectives. (DB)

Trends in Education Philanthropy: A Roundtable with Foundation Leaders

ERIC Educational Resources Information Center

Connection: The Journal of the New England Board of Higher Education, 2006

2006-01-01

In February 2006, Nellie Mae Education Foundation President and Chief Executive Officer Blenda J. Wilson convened a roundtable discussion on trends in education philanthropy. Wilson's guests were Ron Ancrum, president of Associated Grant Makers, which serves grantmaking members in Massachusetts and New Hampshire; Nancy P. Roberts, president of the…

Inspection Time: A Biomarker for Cognitive Decline

ERIC Educational Resources Information Center

Gregory, Tess; Nettelbeck, Ted; Howard, Sara; Wilson, Carlene

2008-01-01

Inspection Time (IT) is a psychophysical speed measure that has been linked to a range of cognitive abilities with results finding that shorter IT is associated with superior performance in cognitive abilities. Following a recent suggestion by Nettelbeck and Wilson [Nettelbeck, T., & Wilson, C. (2004). The Flynn effect: Smarter not faster.…

Stopover ecology and habitat use of migratory Wilson's Warblers

Treesearch

Wang Yong; Deborah M. Finch; Frank R. Moore; Jeffrey F. Kelly

1998-01-01

The conservation of long-distance migratory songbirds is complicated by their life-history characteristics and the spatial scales that they traverse. Events during migratory stopovers may have significant consequences in determining the population status of migratory songbirds. Using Wilson's Warbler (Wilsonia pusilla) as a focal species, we investigated effects...

Wilson Reading System[R]. What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2007

2007-01-01

Wilson Reading System[R] is a supplemental reading and writing curriculum designed to promote reading accuracy (decoding) and spelling (encoding) skills for students with word-level deficits. The program is designed to teach phonemic awareness, alphabetic principles (sound-symbol relationship), word study, spelling, sight word instruction,…

76 FR 3176 - Proposed Extension of Existing Information Collection; Records of Tests and of Examinations of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

..., Regulations, and Variances, 1100 Wilson Boulevard, Room 2350, Arlington, VA 22209-3939. (4) Hand Delivery or Courier: MSHA, Office of Standards, Regulations, and Variances, 1100 Wilson Boulevard, Room 2350... CONTACT: Mario Distasio, Chief of the Economic Analysis Division, Office of Standards, Regulations, and...

Converting the H. W. Wilson Company Indexes to an Automated System: A Functional Analysis.

ERIC Educational Resources Information Center

Regazzi, John J.

1984-01-01

Description of the computerized information system that supports the editorial and manufacturing processes involved in creation of Wilson's subject indexes and catalogs includes the major subsystems--online data entry, batch input processing, validation and release, file generation and database management, online and offline retrieval, publication…

The Development of Field Guides for Birding: Gwillim, Wilson, Audubon and Peterson.

ERIC Educational Resources Information Center

Cameron, Teddy

2000-01-01

Discusses the increasing interest of the public in nature and art of the 18th and 19th centuries, and making watercolor painting a part of the curriculum. Focuses on the works and publishing of Gwillim, Wilson, Audubon, and Peterson. (Contains 12 references.) (YDS)

Municipal Broadband in Wilson, North Carolina: A Study

ERIC Educational Resources Information Center

O'Boyle, Timothy

2012-01-01

Relatively little empirical attention has been paid to the political economy of publicly-retailed fiber-optic broadband internet service. To address this gap in the literature, this dissertation examines the history, dynamics and trends in the municipal broadband movement. In specific, Wilson, North Carolina's Greenlight service is examined in…

Big Brains, Small Impact

ERIC Educational Resources Information Center

Jacoby, Russell

2008-01-01

Earlier 20th-century thinkers like Lewis Mumford and Edmund Wilson kept the university and its apparatus at arm's length. Indeed, they often disdained it. They oriented themselves toward an educated public, and, as a result, they developed a straightforward prose and gained a nonprofessional audience. As his reputation grew, Wilson printed up a…

Discovery Learning in Autonomous Agents Using Genetic Algorithms

DTIC Science & Technology

1993-12-01

Meyer and Wilson (47). 65. Roitblat , H. L., et al. "Biomimetic Sonar Processing: Prom Dolphin Echoloc-Ation to Artificial Neural Networks." In Meyer and...34 In Meyer and Wilson (47). 65. Roitblat , H. L., et al. "Biomimetic Sonar Processing: From Dolphin Echolocation to Artificial Neural Networks." In

Wilson Reading System.

ERIC Educational Resources Information Center

Education Commission of the States, Denver, CO.

This paper provides an overview of the Wilson Reading System, which teaches students word structure and language through a carefully sequenced, 12-step system that helps them master decoding and spelling. The program targets the needs of students at all levels (K-12), specifically students with language learning disabilities such as dyslexia;…

Rodin, Patton, Edison, Wilson, Einstein: Were They Really Learning Disabled?

ERIC Educational Resources Information Center

Adelman, Kimberly A.; Adelman, Howard S.

1987-01-01

The practice of posthumously diagnosing historical figures is discussed. Emphasis is on the unsatisfactory nature of evidence found for those diagnosed as learning-disabled or dyslexic and the possibility of other explanations for identified problems. Posthumous diagnoses of Auguste Rodin, George Patton, Thomas Edison, Woodrow Wilson, and Albert…

Probing topological order with Rényi entropy

NASA Astrophysics Data System (ADS)

Halász, Gábor B.; Hamma, Alioscia

2012-12-01

We present an analytical study of the quantum phase transition between the topologically ordered toric-code-model ground state and the disordered spin-polarized state. The phase transition is induced by applying an external magnetic field, and the variation in topological order is detected via two nonlocal quantities: the Wilson loop and the topological Rényi entropy of order 2. By exploiting an equivalence with the transverse-field Ising model and considering two different variants of the problem, we investigate the field dependence of these quantities by means of an exact treatment in the exactly solvable variant and complementary perturbation theories around the limits of zero and infinite fields in both variants. We find strong evidence that the phase transition point between topological order and disorder is marked by a discontinuity in the topological Rényi entropy and that the two phases around the phase transition point are characterized by its different constant values. Our results therefore indicate that the topological Rényi entropy is a proper topological invariant: its allowed values are discrete and can be used to distinguish between different phases of matter.

Coulomb branch operators and mirror symmetry in three dimensions

NASA Astrophysics Data System (ADS)

Dedushenko, Mykola; Fan, Yale; Pufu, Silviu S.; Yacoby, Ran

2018-04-01

We develop new techniques for computing exact correlation functions of a class of local operators, including certain monopole operators, in three-dimensional N=4 abelian gauge theories that have superconformal infrared limits. These operators are position-dependent linear combinations of Coulomb branch operators. They form a one-dimensional topological sector that encodes a deformation quantization of the Coulomb branch chiral ring, and their correlation functions completely fix the ( n ≤ 3)-point functions of all half-BPS Coulomb branch operators. Using these results, we provide new derivations of the conformal dimension of half-BPS monopole operators as well as new and detailed tests of mirror symmetry. Our main approach involves supersymmetric localization on a hemisphere HS 3 with half-BPS boundary conditions, where operator insertions within the hemisphere are represented by certain shift operators acting on the HS 3 wavefunction. By gluing a pair of such wavefunctions, we obtain correlators on S 3 with an arbitrary number of operator insertions. Finally, we show that our results can be recovered by dimensionally reducing the Schur index of 4D N=2 theories decorated by BPS 't Hooft-Wilson loops.

Holographic constraints on Bjorken hydrodynamics at finite coupling

NASA Astrophysics Data System (ADS)

DiNunno, Brandon S.; Grozdanov, Sašo; Pedraza, Juan F.; Young, Steve

2017-10-01

In large- N c conformal field theories with classical holographic duals, inverse coupling constant corrections are obtained by considering higher-derivative terms in the corresponding gravity theory. In this work, we use type IIB supergravity and bottom-up Gauss-Bonnet gravity to study the dynamics of boost-invariant Bjorken hydrodynamics at finite coupling. We analyze the time-dependent decay properties of non-local observables (scalar two-point functions and Wilson loops) probing the different models of Bjorken flow and show that they can be expressed generically in terms of a few field theory parameters. In addition, our computations provide an analytically quantifiable probe of the coupling-dependent validity of hydrodynamics at early times in a simple model of heavy-ion collisions, which is an observable closely analogous to the hydrodynamization time of a quark-gluon plasma. We find that to third order in the hydrodynamic expansion, the convergence of hydrodynamics is improved and that generically, as expected from field theory considerations and recent holographic results, the applicability of hydrodynamics is delayed as the field theory coupling decreases.

The Kaon B-parameter in mixed action chiral perturbation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aubin, C.; /Columbia U.; Laiho, Jack

2006-09-01

We calculate the kaon B-parameter, B{sub K}, in chiral perturbation theory for a partially quenched, mixed action theory with Ginsparg-Wilson valence quarks and staggered sea quarks. We find that the resulting expression is similar to that in the continuum, and in fact has only two additional unknown parameters. At one-loop order, taste-symmetry violations in the staggered sea sector only contribute to flavor-disconnected diagrams by generating an {Omicron}(a{sup 2}) shift to the masses of taste-singlet sea-sea mesons. Lattice discretization errors also give rise to an analytic term which shifts the tree-level value of B{sub K} by an amount of {Omicron}(a{sup 2}).more » This term, however, is not strictly due to taste-breaking, and is therefore also present in the expression for B{sub K} for pure G-W lattice fermions. We also present a numerical study of the mixed B{sub K} expression in order to demonstrate that both discretization errors and finite volume effects are small and under control on the MILC improved staggered lattices.« less

Functional determinants of radial operators in AdS2

DOE PAGES

Aguilera-Damia, Jeremías; Faraggi, Alberto; Zayas, Leopoldo Pando; ...

2018-06-01

We study the zeta-function regularization of functional determinants of Laplace and Dirac-type operators in two-dimensional Euclidean AdS2 space. More specifically, we consider the ratio of determinants between an operator in the presence of background fields with circular symmetry and the free operator in which the background fields are absent. By Fourier-transforming the angular dependence, one obtains an infinite number of one-dimensional radial operators, the determinants of which are easy to compute. The summation over modes is then treated with care so as to guarantee that the result coincides with the two-dimensional zeta-function formalism. The method relies on some well-known techniquesmore » to compute functional determinants using contour integrals and the construction of the Jost function from scattering theory. Our work generalizes some known results in flat space. The extension to conformal AdS2 geometries is also considered. We provide two examples, one bosonic and one fermionic, borrowed from the spectrum of fluctuations of the holographic 1/4-BPS latitude Wilson loop.« less

An /N=2 gauge theory and its supergravity dual

NASA Astrophysics Data System (ADS)

Brandhuber, A.; Sfetsos, K.

2000-09-01

We study flows on the scalar manifold of /N=8 gauged supergravity in five dimensions which are dual to certain mass deformations of /N=4 super Yang-Mills theory. In particular, we consider a perturbation of the gauge theory by a mass term for the adjoint hyper-multiplet, giving rise to an /N=2 theory. The exact solution of the 5-dim gauged supergravity equations of motion is found and the metric is uplifted to a ten-dimensional background of type-IIB supergravity. Using these geometric data and the AdS/CFT correspondence we analyze the spectra of certain operators as well as Wilson loops on the dual gauge theory side. The physical flows are parametrized by a single non-positive constant and describe part of the Coulomb branch of the /N=2 theory at strong coupling. We also propose a general criterion to distinguish between `physical' and `unphysical' curvature singularities. Applying it in many backgrounds arising within the AdS/CFT correspondence we find results that are in complete agreement with field theory expectations.

Interquark potential with finite quark mass from lattice QCD.

PubMed

Kawanai, Taichi; Sasaki, Shoichi

2011-08-26

We present an investigation of the interquark potential determined from the q ̄q Bethe-Salpeter (BS) amplitude for heavy quarkonia in lattice QCD. The q ̄q potential at finite quark mass m(q) can be calculated from the equal-time and Coulomb gauge BS amplitude through the effective Schrödinger equation. The definition of the potential itself requires information about a kinetic mass of the quark. We then propose a self-consistent determination of the quark kinetic mass on the same footing. To verify the proposed method, we perform quenched lattice QCD simulations with a relativistic heavy-quark action at a lattice cutoff of 1/a≈2.1  GeV in a range 1.0≤m(q)≤3.6 GeV. Our numerical results show that the q ̄q potential in the m(q)→∞ limit is fairly consistent with the conventional one obtained from Wilson loops. The quark-mass dependence of the q ̄q potential and the spin-spin potential are also examined. © 2011 American Physical Society

The Human Performance Envelope: Past Research, Present Activities and Future Directions

NASA Technical Reports Server (NTRS)

Edwards, Tamsyn

2017-01-01

Air traffic controllers (ATCOs) must maintain a consistently high level of human performance in order to maintain flight safety and efficiency. In current control environments, performance-influencing factors such as workload, fatigue and situation awareness can co-occur, and interact, to effect performance. However, multifactor influences and the association with performance are under-researched. This study utilized a high fidelity human in the loop enroute air traffic control simulation to investigate the relationship between workload, situation awareness and ATCO performance. The study aimed to replicate and extend Edwards, Sharples, Wilson and Kirwans (2012) previous study and confirm multifactor interactions with a participant sample of ex-controllers. The study also aimed to extend Edwards et als previous research by comparing multifactor relationships across 4 automation conditions. Results suggest that workload and SA may interact to produce a cumulative impact on controller performance, although the effect of the interaction on performance may be dependent on the context and amount of automation present. Findings have implications for human-automation teaming in air traffic control, and the potential prediction and support of ATCO performance.

Sulphation of CaO-Based Sorbent Modified in CO2 Looping Cycles

NASA Astrophysics Data System (ADS)

Manovic, Vasilije; Anthony, Edward J.; Loncarevic, Davor

CaO-based looping cycles for CO2 capture at high temperatures are based on cyclical carbonation of CaO and regeneration of CaCO3. The main limitation of natural sorbents is the loss of carrying capacity with increasing numbers of reaction cycles, resulting in spent sorbent ballast. Use of spent sorbent from CO2 looping cycles for SO2 capture is a possible solution investigated in this study. Three limestones were investigated: Kelly Rock (Canada), La Blanca (Spain) and Katowice (Poland). Carbonation/calcination cycles were performed in a tube furnace with original limestones and samples thermally pretreated for different times (i.e., sintered). The spent sorbent samples were sulphated in a thermogravimetric analyzer. Changes in the resulting pore structure were then investigated using mercury porosimetry. Final conversions of both spent and pretreated sorbents after longer sulphation times were comparable or higher than those observed for the original sorbents. Maximum sulphation levels strongly depend on sorbent porosity and pore surface area. The shrinkage of sorbent particles during calcination/cycling resulted in a loss of sorbent porosity (≤48%), which corresponds to maximum sulphation levels ˜55% for spent Kelly Rock and Katowice. However, this is ˜10% higher than for the original samples. By contrast, La Blanca limestone had more pronounced particle shrinkage during pretreatment and cycling, leading to lower porosity, <35%, resulting in sulphation conversion of spent samples <30%, significantly lower than for the original sample (45%). These results showed that spent sorbent samples from CO2 looping cycles can be used as sorbents for SO2 retention if significant porosity loss does not occur during CO2 reaction cycles. For spent Kelly Rock and Katowice samples final conversions are determined by the total pore volume available for the bulky CaSO4 product.

Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011

NASA Astrophysics Data System (ADS)

Kourghi, Mohamad; De Ieso, Michael L.; Nourmohammadi, Saeed; Pei, Jinxin V.; Yool, Andrea J.

2018-04-01

Aquaporins are integral proteins that facilitate the transmembrane transport of water and small solutes. In addition to enabling water flux, mammalian Aquaporin-1 (AQP1) channels activated by cyclic GMP can carry non-selective monovalent cation currents, selectively blocked by arylsulfonamide compounds AqB007 (IC50 170 µM) and AqB011 (IC50 14 µM). In silico models suggested that ligand docking might involve the cytoplasmic loop D (between AQP1 transmembrane domains 4 and 5), but the predicted site of interaction remained to be tested. Work here shows that mutagenesis of two conserved arginine residues in loop D slowed the activation of the AQP1 ion conductance and impaired the sensitivity of the channel to block by AqB011. Substitution of residues in loop D with proline showed effects on ion conductance amplitude that varied with position, suggesting that the structural conformation of loop D is important for AQP1 channel gating. Human AQP1 wild type, AQP1 mutant channels with alanines substituted for two arginines (R159A+R160A), and mutants with proline substituted for single residues threonine (T157P), aspartate (D158P), arginine (R159P, R160P) or glycine (G165P) were expressed in Xenopus laevis oocytes. Conductance responses were analyzed by two-electrode voltage clamp. Optical osmotic swelling assays and confocal microscopy were used to confirm mutant and wild type AQP1-expressing oocytes were expressed in the plasma membrane. After application of membrane-permeable cGMP, R159A+R160A channels had a significantly slower rate of activation as compared with wild type, consistent with impaired gating. AQP1 R159A+R160A channels showed no significant block by AqB011 at 50 µM, in contrast to the wild type channel which was blocked effectively. T157P, D158P and R160P mutations had impaired activation compared to wild type; R159P showed no significant effect; and G165P appeared to augment the conductance amplitude. These findings provide evidence for the role of the loop D as a gating domain for AQP1 ion channels, and identify the likely site of interaction of AqB011 in the proximal loop D sequence.

Elevated copper impairs hepatic nuclear receptor function in Wilson's disease

USDA-ARS?s Scientific Manuscript database

Wilson's disease (WD) is an autosomal recessive disorder that results in accumulation of copper in the liver as a consequence of mutations in the gene encoding the copper-transporting P-type ATPase (ATP7B). WD is a chronic liver disorder, and individuals with the disease present with a variety of co...

19. VIEW OF EAST ELEVATION. THOMAS G. WILSON ADDED THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. VIEW OF EAST ELEVATION. THOMAS G. WILSON ADDED THE ONE-STORY RETAIL STORE IN 1958. IT REPLACED A SMALLER ONE-STORY OFFICE IN THE SAME LOCATION. Photographer: Louise Taft Cawood, July 1986 - Alexander's Grist Mill, Lock 37 on Ohio & Erie Canal, South of Cleveland, Valley View, Cuyahoga County, OH

A Stability Police Force for the United States: Justification and Options for Creating U.S. Capabilities

DTIC Science & Technology

2009-01-01

Investigative Analysis, Ottawa: Royal Canadian Mounted Police, 2007; John E. Eck , Spencer Chainey, James G. Cameron , Michael Leitner, and Ronald E. Wilson...Kuwait,” Parameters, Vol. 21, No. 4, Winter 1991–1992. Eck , John E., Spencer Chainey, James G. Cameron , Michael Leitner, and Ronald E. Wilson

Our Universe from the cosmological constant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barrau, Aurélien; Linsefors, Linda, E-mail: Aurelien.Barrau@cern.ch, E-mail: linda.linsefors@lpsc.in2p3.fr

The issue of the origin of the Universe and of its contents is addressed in the framework of bouncing cosmologies, as described for example by loop quantum gravity. If the current acceleration is due to a true cosmological constant, this constant is naturally conserved through the bounce and the Universe should also be in a (contracting) de Sitter phase in the remote past. We investigate here the possibility that the de Sitter temperature in the contracting branch fills the Universe with radiation that causes the bounce and the subsequent inflation and reheating. We also consider the possibility that this givesmore » rise to a cyclic model of the Universe and suggest some possible tests.« less

Time-domain multiplexed high resolution fiber optics strain sensor system based on temporal response of fiber Fabry-Perot interferometers.

PubMed

Chen, Jiageng; Liu, Qingwen; He, Zuyuan

2017-09-04

We developed a multiplexed strain sensor system with high resolution using fiber Fabry-Perot interferometers (FFPI) as sensing elements. The temporal responses of the FFPIs excited by rectangular laser pulses are used to obtain the strain applied on each FFPI. The FFPIs are connected by cascaded couplers and delay fiber rolls for the time-domain multiplexing. A compact optoelectronic system performing closed-loop cyclic interrogation is employed to improve the sensing resolution and the frequency response. In the demonstration experiment, 3-channel strain sensing with resolutions better than 0.1 nε and frequency response higher than 100 Hz is realized.

Analysis of fixed bed data for the extraction of a rate mechanism for the reaction of hematite with methane

DOE PAGES

Breault, Ronald W.; Monazam, Esmail R.

2015-04-01

In this study, chemical looping combustion is a promising technology for the capture of CO 2 involving redox materials as oxygen carriers. The effects of reduction conditions, namely, temperature and fuel partial pressure on the conversion products are investigated. The experiments were conducted in a laboratory fixed-bed reactor that was operated cyclically with alternating reduction and oxidation periods. Reactions are assumed to occur in the shell surrounding the particle grains with diffusion of oxygen to the surface from the grain core. Activation energies for the shell and core reactions range from 9 to 209 kJ/mol depending on the reaction step.

Biodiversity in models of cyclic dominance is preserved by heterogeneity in site-specific invasion rates.

PubMed

Szolnoki, Attila; Perc, Matjaž

2016-12-05

Global, population-wide oscillations in models of cyclic dominance may result in the collapse of biodiversity due to the accidental extinction of one species in the loop. Previous research has shown that such oscillations can emerge if the interaction network has small-world properties, and more generally, because of long-range interactions among individuals or because of mobility. But although these features are all common in nature, global oscillations are rarely observed in actual biological systems. This begets the question what is the missing ingredient that would prevent local oscillations to synchronize across the population to form global oscillations. Here we show that, although heterogeneous species-specific invasion rates fail to have a noticeable impact on species coexistence, randomness in site-specific invasion rates successfully hinders the emergence of global oscillations and thus preserves biodiversity. Our model takes into account that the environment is often not uniform but rather spatially heterogeneous, which may influence the success of microscopic dynamics locally. This prevents the synchronization of locally emerging oscillations, and ultimately results in a phenomenon where one type of randomness is used to mitigate the adverse effects of other types of randomness in the system.

Modeling of a viscoelastic damper and its application in structural control

PubMed Central

Ibrahim, Zainah; Ghodsi, S. S.; Khatibi, Hamed

2017-01-01

Conventional seismic rehabilitation methods may not be suitable for some buildings owing to their high cost and time-consuming foundation work. In recent years, viscoelastic dampers (VEDs) have been widely used in many mid- and high-rise buildings. This study introduces a viscoelastic passive control system called rotary rubber braced damper (RRBD). The RRBD is an economical, lightweight, and easy-to-assemble device. A finite element model considering nonlinearity, large deformation, and material damage is developed to conduct a parametric study on different damper sizes under pushover cyclic loading. The fundamental characteristics of this VED system are clarified by analyzing building structures under cyclic loading. The result show excellent energy absorption and stable hysteresis loops in all specimens. Additionally, by using a sinusoidal shaking table test, the effectiveness of the RRBD to manage the response displacement and acceleration of steel frames is considered. The RRBD functioned at early stages of lateral displacement, indicating that the system is effective for all levels of vibration. Moreover, the proposed damper shows significantly better performance in terms of the column compression force resulting from the brace action compared to chevron bracing (CB). PMID:28570657

Synthesis of protein in intestinal cells exposed to cholera toxin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, J.W.; Berg, W.D. Jr.; Coppenhaver, D.H.

1987-11-01

The mechanism by which cyclic adenosine monophosphate (AMP), formed by intestinal epithelial cells in response to cholera toxin, ultimately results in alterations in water and electrolyte transport is poorly understood. Several studies have indicated that inhibitors of transcription or translation block much of the transport of ions and water in the intestine and edema formation in tissue elicited by cholera toxin. Data presented in this study confirmed the inhibitory effects of cycloheximide on cholera toxin-induced fluid accumulation in the rabbit intestinal loop model. Neither cycloheximide nor actinomycin D altered the amount of cyclic AMP that accumulated in intestinal cells andmore » Chinese hamster ovary cells exposed to cholera toxin. An increase in (/sup 3/H) leucine incorporation was readily demonstrable in intestinal epithelial cells from rabbits challenged with Vibrio cholerae. Similarly, intestinal epithelial cells incubated with cholera toxin for 4 hr synthesized substantially more protein than controls as determined by relative incorporation of (/sup 35/S) methionine. Most of the new protein synthesized in response to cholera toxin was membrane associated and of high molecular weight. The possible significance of the toxin-induced protein relative to cholera pathogenesis was discussed.« less

Biodiversity in models of cyclic dominance is preserved by heterogeneity in site-specific invasion rates

NASA Astrophysics Data System (ADS)

Szolnoki, Attila; Perc, Matjaž

2016-12-01

Global, population-wide oscillations in models of cyclic dominance may result in the collapse of biodiversity due to the accidental extinction of one species in the loop. Previous research has shown that such oscillations can emerge if the interaction network has small-world properties, and more generally, because of long-range interactions among individuals or because of mobility. But although these features are all common in nature, global oscillations are rarely observed in actual biological systems. This begets the question what is the missing ingredient that would prevent local oscillations to synchronize across the population to form global oscillations. Here we show that, although heterogeneous species-specific invasion rates fail to have a noticeable impact on species coexistence, randomness in site-specific invasion rates successfully hinders the emergence of global oscillations and thus preserves biodiversity. Our model takes into account that the environment is often not uniform but rather spatially heterogeneous, which may influence the success of microscopic dynamics locally. This prevents the synchronization of locally emerging oscillations, and ultimately results in a phenomenon where one type of randomness is used to mitigate the adverse effects of other types of randomness in the system.

Biomechanical evaluation of different suture techniques for arthroscopic transtibial pull-out repair of posterior medial meniscus root tears.

PubMed

Feucht, Matthias J; Grande, Eduardo; Brunhuber, Johannes; Burgkart, Rainer; Imhoff, Andreas B; Braun, Sepp

2013-12-01

A tear of the posterior medial meniscus root (PMMR) is increasingly recognized as a serious knee joint injury. Several suture techniques for arthroscopic transtibial pull-out repair have been described; however, only limited data about the biomechanical properties of these techniques are currently available. There are significant differences between the tested suture techniques, with more complex suture configurations providing superior biomechanical properties. Controlled laboratory study. A total of 40 porcine medial menisci were randomly assigned to 1 of 4 groups (10 specimens each) according to suture technique: two simple stitches (TSS), horizontal mattress suture (HMS), modified Mason-Allen suture (MMA), and two modified loop stitches (TLS). Meniscus-suture constructs were subjected to cyclic loading followed by load-to-failure testing in a servohydraulic material testing machine. During cyclic loading, the HMS and TLS groups showed a significantly higher displacement after 100, 500, and 1000 cycles compared with the TSS and MMA groups. After 1000 cycles, the highest displacement was found for the TLS group, with significant differences compared with all other groups. During load-to-failure testing, the highest maximum load and yield load were observed for the MMA group, with statistically significant differences compared with the TSS and TLS groups. With regard to stiffness, the TSS and MMA groups showed significantly higher values compared with the HMS and TLS groups. The MMA technique provided the best biomechanical properties with regard to cyclic loading and load-to-failure testing. The TSS technique seems to be a valuable alternative. Both the HMS and TLS techniques have the disadvantage of lower stiffness and higher displacement during cyclic loading. Using a MMA technique may improve healing rates and avoid progressive extrusion of the medial meniscus after transtibial pull-out repair of PMMR tears. The TSS technique may be used as an alternative that is easier to perform, but a more careful rehabilitation program is possibly necessary to avoid early failure.

High-temperature low cycle fatigue behavior of a gray cast iron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, K.L., E-mail: 12klfan@tongji.edu.cn; He, G.Q.; She, M.

The strain controlled low cycle fatigue properties of the studied gray cast iron for engine cylinder blocks were investigated. At the same total strain amplitude, the low cycle fatigue life of the studied material at 523 K was higher than that at 423 K. The fatigue behavior of the studied material was characterized as cyclic softening at any given total strain amplitude (0.12%–0.24%), which was attributed to fatigue crack initiation and propagation. Moreover, this material exhibited asymmetric hysteresis loops due to the presence of the graphite lamellas. Transmission electron microscopy analysis suggested that cyclic softening was also caused by themore » interactions of dislocations at 423 K, such as cell structure in ferrite, whereas cyclic softening was related to subgrain boundaries and dislocation climbing at 523 K. Micro-analysis of specimen fracture appearance was conducted in order to obtain the fracture characteristics and crack paths for different strain amplitudes. It showed that the higher the temperature, the rougher the crack face of the examined gray cast iron at the same total strain amplitude. Additionally, the microcracks were readily blunted during growth inside the pearlite matrix at 423 K, whereas the microcracks could easily pass through pearlite matrix along with deflection at 523 K. The results of fatigue experiments consistently showed that fatigue damage for the studied material at 423 K was lower than that at 523 K under any given total strain amplitude. - Highlights: • The low cycle fatigue behavior of the HT250 for engine cylinder blocks was investigated. • TEM investigations were conducted to explain the cyclic deformation response. • The low cycle fatigue cracks of HT250 GCI were studied by SEM. • The fatigue life of the examined material at 523 K is higher than that at 423 K.« less

High-resolution tephrochronology of the Wilson Creek Formation (Mono Lake, California) and Laschamp event using 238U-230Th SIMS dating of accessory mineral rims

NASA Astrophysics Data System (ADS)

Vazquez, Jorge A.; Lidzbarski, Marsha I.

2012-12-01

Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and tephras yield discordant results due to open-system effects and radiocarbon reservoir uncertainties as well as abundant xenocrysts. New ion microprobe 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yield ages that effectively date eruption of key tephra beds and delimit the timing of basal Wilson Creek sedimentation to the interval between 26.8±2.1 and 61.7±1.9 ka. Tephra (Ash 15) erupted during the geomagnetic excursion originally designated the Mono Lake excursion yields an age of 40.8±1.9 ka, indicating that the event is instead the Laschamp excursion. The new ages support a depositional chronology from magnetostratigraphy that indicates quasi-synchronous glacial and hydrologic responses in the Sierra Nevada and Mono Basin to regional climate change, with intervals of lake filling and glacial-snowpack melting that are in phase with peaks in spring insolation.

The mantle lithosphere and the Wilson Cycle

NASA Astrophysics Data System (ADS)

Heron, Philip; Pysklywec, Russell; Stephenson, Randell

2017-04-01

In the view of the conventional theory of plate tectonics (e.g., the Wilson Cycle), crustal inheritance is often considered important in tectonic evolution. However, the role of the mantle lithosphere is usually overlooked due to its difficulty to image and uncertainty in rheological makeup. Deep seismic imaging has shown potential scarring in continental mantle lithosphere to be ubiquitous. Recent studies have interpreted mantle lithosphere heterogeneities to be pre-existing structures, and as such linked to the Wilson Cycle and inheritance. In our study, we analyze intraplate deformation driven by mantle lithosphere heterogeneities from ancient Wilson Cycle processes and compare this to crustal inheritance deformation. We present 2-D numerical experiments of continental convergence to generate intraplate deformation, exploring the limits of continental rheology to understand the dominant lithosphere layer across a broad range of geological settings. By implementing a "jelly sandwich" rheology, characteristic of stable continental lithosphere, we find that during compression the strength of the mantle lithosphere is integral in controlling deformation from a structural anomaly. We posit that if the continental mantle is the strongest layer within the lithosphere, then such inheritance may have important implications for the Wilson Cycle. Furthermore, our models show that deformation driven by mantle lithosphere scarring can produce tectonic patterns related to intraplate orogenesis originating from crustal sources, highlighting the need for a more formal discussion of the role of the mantle lithosphere in plate tectonics. We outline the difficulty in unravelling the causes of tectonic deformation, alongside discussing the role of deep lithosphere processes in plate tectonics.

[Wilsons disease].

PubMed

Mareček, Z; Brůha, R

2013-07-01

Wilsons disease is an autosomal recessive genetic disorder in which copper accumulates in tissues, especially in the liver and the brain. The genetic defect affects the P type ATPase gene (ATP7B). More than 500 mutations causing Wilsons disease have been described. The most common mutation in Central Europe concerns H1069Q. The symptoms of Wilsons disease include hepatic or neurological conditions. The hepatic condition is manifested as steatosis, acute or chronic hepatitis or cirrhosis. The neurological conditions are most often manifested after the age of 20 as motor disorders (tremor, speech and writing disorders), which may result in severe extrapyramidal syndrome with rigidity, dysarthria and muscle contractions. The dia-gnosis is based on clinical and laboratory assessments (neurological signs, liver lesions, low ceruloplasmin, increased free serum copper, high Cu volumes in urine, KayserFleischer ring). The dia-gnosis is confirmed by a high Cu level in liver tissue or genetic proof. Untreated Wilsons disease causes death of the patient. If treated properly the survival rate approximates to the survival rate of the common population. The treatment concerns either removal of copper from the body using chelating agents excreted into the urine (Penicillamine, Trientine) or limitation of copper absorption from the intestine and reducing the toxicity of copper (zinc, ammonium tetrathiomolybdate). In the Czech Republic, Penicillamine or zinc is used. A liver transplant is indicated in patients with fulminant hepatic failure or decompensated liver cirrhosis. In the family all siblings of the affected individual need to be screened in order to treat any asymptomatic subjects.

Hypersialorrhea in Wilson's Disease.

PubMed

Trocello, Jean-Marc; Osmani, Karima; Pernon, Michaela; Chevaillier, Gérard; de Brugière, Claire; Remy, Pascal; Wenisch, Emilie; Cousin, Catherine; Girardot-Tinant, Nadège; Woimant, France

2015-10-01

Hypersialorrhea, corresponding to excessive salivation is a symptom frequently reported in Wilson's disease, especially in its neurological form. The prevalence of this frequent complaint has not been often evaluated. During a 7-month period, 87 consecutive Wilson's disease patients answered to the simple question "do you have the sensation of excess saliva in your mouth?" to evaluate the frequency of this symptom. A sub-sample of 10 consecutive Wilson's disease patients with drooling was recruited to undergo quantitative and qualitative measures to evaluate the mechanism of hypersialorrhea. Excessive drooling or excess saliva was found in 46 % of patients followed at the French Reference Centre. Ninety-eight percent of them presented neurological symptoms and drooling was found in only one patient without neurological symptoms. Our study showed that patients with a complaint of excessive saliva produced significantly higher quantities of saliva at rest than controls. Endoscopic examination was abnormal in six patients. A significant decrease of swallowing frequency, longer swallow latencies, and poor swallowing capacities may partly explain the salivary stasis. Oropharyngeal sensitivity disorders were present in 50 % of our patients. The decrease of the swallowing frequency observed in all patients could be related to cognitive and behavioral abnormalities with initiation difficulties objectified by longer latencies triggered by all the ingested volumes. This study confirmed the hypothesis of a multifactorial origin of hypersialorrhea in patients who have been diagnosed in Wilson's disease. It was essential to evaluate drooling with a multidisciplinary consultation to better identify the underlying mechanisms and to implement strategies for speech therapy and therapeutic adaptation.

High-resolution tephrochronology of the Wilson Creek Formation (Mono Lake, California) and Laschamp event using 238U-230Th SIMS dating of accessory mineral rims

USGS Publications Warehouse

Vazquez, Jorge A.; Lidzbarski, Marsha I.

2012-01-01

Sediments of the Wilson Creek Formation surrounding Mono Lake preserve a high-resolution archive of glacial and pluvial responses along the eastern Sierra Nevada due to late Pleistocene climate change. An absolute chronology for the Wilson Creek stratigraphy is critical for correlating the paleoclimate record to other archives in the western U.S. and the North Atlantic region. However, multiple attempts to date the Wilson Creek stratigraphy using carbonates and tephras yield discordant results due to open-system effects and radiocarbon reservoir uncertainties as well as abundant xenocrysts. New ion microprobe 238U-230Th dating of the final increments of crystallization recorded by allanite and zircon autocrysts from juvenile pyroclasts yield ages that effectively date eruption of key tephra beds and delimit the timing of basal Wilson Creek sedimentation to the interval between 26.8±2.1 and 61.7±1.9 ka. Tephra (Ash 15) erupted during the geomagnetic excursion originally designated the Mono Lake excursion yields an age of 40.8±1.9 ka, indicating that the event is instead the Laschamp excursion. The new ages support a depositional chronology from magnetostratigraphy that indicates quasi-synchronous glacial and hydrologic responses in the Sierra Nevada and Mono Basin to regional climate change, with intervals of lake filling and glacial-snowpack melting that are in phase with peaks in spring insolation.

Laser ablation inductively coupled plasma mass spectrometry imaging of metals in experimental and clinical Wilson's disease

PubMed Central

Boaru, Sorina Georgiana; Merle, Uta; Uerlings, Ricarda; Zimmermann, Astrid; Flechtenmacher, Christa; Willheim, Claudia; Eder, Elisabeth; Ferenci, Peter; Stremmel, Wolfgang; Weiskirchen, Ralf

2015-01-01

Wilson's disease is an autosomal recessive disorder in which the liver does not properly release copper into bile, resulting in prominent copper accumulation in various tissues. Affected patients suffer from hepatic disorders and severe neurological defects. Experimental studies in mutant mice in which the copper-transporting ATPase gene (Atp7b) is disrupted revealed a drastic, time-dependent accumulation of hepatic copper that is accompanied by formation of regenerative nodes resembling cirrhosis. Therefore, these mice represent an excellent exploratory model for Wilson's disease. However, the precise time course in hepatic copper accumulation and its impact on other trace metals within the liver is yet poorly understood. We have recently established novel laser ablation inductively coupled plasma mass spectrometry protocols allowing quantitative metal imaging in human and murine liver tissue with high sensitivity, spatial resolution, specificity and quantification ability. By use of these techniques, we here aimed to comparatively analyse hepatic metal content in wild-type and Atp7b deficient mice during ageing. We demonstrate that the age-dependent accumulation of hepatic copper is strictly associated with a simultaneous increase in iron and zinc, while the intrahepatic concentration and distribution of other metals or metalloids is not affected. The same findings were obtained in well-defined human liver samples that were obtained from patients suffering from Wilson's disease. We conclude that in Wilson's disease the imbalances of hepatic copper during ageing are closely correlated with alterations in intrahepatic iron and zinc content. PMID:25704483

Evaluating the Correlation between Anteroposterior and Mediolateral Compensatory Curves and their Influence on Dentoskeletal Morphology-An In vitro CBCT Study.

PubMed

Babu, K Suresh; Kumar, A Nanda; Kommi, Pradeep Babu; Krishnan, P Hari; Kumar, M Senthil; Sabapathy, R Senkutvan; Kumar, V Vijay

2017-08-01

To date, many orthodontist corrects malocclusion based on patients aesthetic concern and fails to correct the compensatory curves. This scenario is due to less insight on understanding relationship of compensatory curves and its correlation in treatment prognosis. The purpose of this study was to evaluate the correlation between the curve of Spee, curve of Monson and curve of Wilson, their influence on dentoskeletal morphology and their contribution to occlusal stability. This study included 104 non-orthodontic models. The study casts were subdivided into two groups, Group-I consist 52 non- orthodontic models with Class-I molar relationship and Group-II consist of 52 non- orthodontic models with Class-II molar relationship. Curve of Spee was measured with digital vernier caliper, curve of Monson estimated using specially made sphere (7″inch, 8″ inch and 9″inch) and curve of Wilson was evaluated using Cone Beam Computed Technology (CBCT). Mean value for curve of Spee obtained for Group I and Group II is 1.844 mm and 3.188 mm. For curve of Monson, the mean value obtained for Group I and Group-II is 7.65 inches and 7.40 inches. The mean degree obtained for the curve of Wilson for Group I and Group-II is 12.05 and 16.49. The result showed positive correlation between curve of Spee and curve of Wilson and no correlation between curve of Monson and curve of Wilson and no correlation between curve of Spee and curve of Monson. The Pearson correlation coefficient analysis from the study confirmed these results. The results showed positive correlation between curve of spee and curve of Wilson. The data found in this study can be applied clinically for Class I and Class II malocclusion patients on diagnosis and treatment planning.

Geodynamic models of the Wilson Cycle: From rifts to mountains to rifts

NASA Astrophysics Data System (ADS)

Buiter, Susanne; Tetreault, Joya; Torsvik, Trond

2015-04-01

The Wilson Cycle theory that oceans close and reopen along the former suture is a fundamental concept in plate tectonics. The theory suggests that subduction initiates at a passive margin, closing the ocean, and that future continental extension localises at the ensuing collision zone. Each stage of the Wilson Cycle will therefore be characterised by inherited structural and thermal heterogeneities. Here we investigate the role of Wilson Cycle inheritance by considering the influence of (1) passive margin structure on continental collision and (2) collision zones on passive margin formation. Passive margins may be preferred locations for subduction initiation because inherited faults and areas of exhumed serpentinized mantle may weaken a margin enough to localise shortening. If subduction initiates at a passive margin, the shape and structure of the passive margins will affect future continental collision. Our review of present-day passive margins along the Atlantic and Indian Oceans reveals that most passive margins are located on former collision zones. Continental break-up occurs on relatively young sutures, such as Morocco-Nova Scotia, and on very old sutures, such as the Greenland-Labrador and East Antarctica-Australia systems. This implies that it is not always post-collisional collapse that initiates the extensional phase of a Wilson Cycle. We highlight the impact of collision zone inheritance on continental extension and rifted margin architecture. We show numerical experiments of one Wilson Cycle of subduction, collision, and extension. Subduction initiates at a tapered passive margin. Closure of a 60 Ma ocean leads to continental collision and slab break-off, followed by some tens of kilometres of slab eduction. Mantle flow above the sinking detached slab enhances deformation in the rift area. The resulting rift exposes not only continental crust, but also subduction-related sediments and oceanic crust remnants. Renewed subduction in the post-collision phase is enabled by lithosphere delamination and slab rollback, leading to back-arc extension in a style similar to the Tyrrhenian Sea.

Analysis of Cyclic Variability of Heat Release for High-EGR GDI Engine Operation with Observations on Implications for Effective Control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaul, Brian C; Wagner, Robert M; Green Jr, Johney Boyd

2013-01-01

Operation of spark-ignition (SI) engines with high levels of charge dilution through exhaust gas recirculation (EGR) achieves significant engine efficiency gains while maintaining stoichiometric operation for compatibility with three-way catalysts. Dilution levels, however, are limited by cyclic variability-including significant numbers of misfires-that becomes more pronounced with increasing dilution. This variability has been shown to have both stochastic and deterministic components. Stochastic effects include turbulence, mixing variations, and the like, while the deterministic effect is primarily due to the nonlinear dependence of flame propagation rates and ignition characteristics on the charge composition, which is influenced by the composition of residual gasesmore » from prior cycles. The presence of determinism implies that an increased understanding the dynamics of such systems could lead to effective control approaches that allow operation near the edge of stability, effectively extending the dilution limit. This nonlinear dependence has been characterized previously for homogeneous charge, port fuel-injected (PFI) SI engines operating fuel-lean as well as with inert diluents such as bottled N2 gas. In this paper, cyclic dispersion in a modern boosted gasoline direct injection (GDI) engine using a cooled external EGR loop is examined, and the potential for improvement with effective control is evaluated through the use of symbol sequence statistics and other techniques from chaos theory. Observations related to the potential implications of these results for control approaches that could effectively enable engine operation at the edge of combustion stability are noted.« less

Long-Term Variability of the Sun in the Context of Solar-Analog Stars

NASA Astrophysics Data System (ADS)

Egeland, Ricky

2018-06-01

The Sun is the best observed object in astrophysics, but despite this distinction the nature of its well-ordered generation of magnetic field in 11-year activity cycles remains a mystery. In this work, we place the solar cycle in a broader context by examining the long-term variability of solar analog stars within 5% of the solar effective temperature, but varied in rotation rate and metallicity. Emission in the Fraunhofer H & K line cores from singly-ionized calcium in the lower chromosphere is due to magnetic heating, and is a proven proxy for magnetic flux on the Sun. We use Ca H & K observations from the Mount Wilson Observatory HK project, the Lowell Observatory Solar Stellar Spectrograph, and other sources to construct composite activity time series of over 100 years in length for the Sun and up to 50 years for 26 nearby solar analogs. Archival Ca H & K observations of reflected sunlight from the Moon using the Mount Wilson instrument allow us to properly calibrate the solar time series to the S-index scale used in stellar studies. We find the mean solar S-index to be 5–9% lower than previously estimated, and the amplitude of activity to be small compared to active stars in our sample. A detailed look at the young solar analog HD 30495, which rotates 2.3 times faster than the Sun, reveals a large amplitude ~12-year activity cycle and an intermittent short-period variation of 1.7 years, comparable to the solar variability time scales despite its faster rotation. Finally, time series analyses of the solar analog ensemble and a quantitative analysis of results from the literature indicate that truly Sun-like cyclic variability is rare, and that the amplitude of activity over both long and short timescales is linearly proportional to the mean activity. We conclude that the physical conditions conducive to a quasi-periodic magnetic activity cycle like the Sun’s are rare in stars of approximately the solar mass, and that the proper conditions may be restricted to a relatively narrow range of rotation rates.

Long-Term Variability of the Sun in the Context of Solar-Analog Stars

NASA Astrophysics Data System (ADS)

Egeland, Ricky

2017-04-01

The Sun is the best observed object in astrophysics, but despite this distinction the nature of its well-ordered generation of magnetic field in 11-year activity cycles remains a mystery. In this work, we place the solar cycle in a broader context by examining the long-term variability of solar analog stars within 5% of the solar effective temperature, but varied in rotation rate and metallicity. Emission in the Fraunhofer H & K line cores from singly-ionized calcium in the lower chromosphere is due to magnetic heating, and is a proven proxy for magnetic flux on the Sun. We use Ca H & K observations from the Mount Wilson Observatory HK project, the Lowell Observatory Solar Stellar Spectrograph, and other sources to construct composite activity time series of over 100 years in length for the Sun and up to 50 years for 26 nearby solar analogs. Archival Ca H & K observations of reflected sunlight from the Moon using the Mount Wilson instrument allow us to properly calibrate the solar time series to the S-index scale used in stellar studies. We find the mean solar S-index to be 5-9% lower than previously estimated, and the amplitude of activity to be small compared to active stars in our sample. A detailed look at the young solar analog HD 30495, which rotates 2.3 times faster than the Sun, reveals a large amplitude 12-year activity cycle and an intermittent short-period variation of 1.7 years, comparable to the solar variability time scales despite its faster rotation. Finally, time series analyses of the solar analog ensemble and a quantitative analysis of results from the literature indicate that truly Sun-like cyclic variability is rare, and that the amplitude of activity over both long and short timescales is linearly proportional to the mean activity. We conclude that the physical conditions conducive to a quasi-periodic magnetic activity cycle like the Sun's are rare in stars of approximately the solar mass, and that the proper conditions may be restricted to a relatively narrow range of rotation rates.

Improving Michigan STEM Teachers and Teaching: The W.K. Kellogg Foundation's Woodrow Wilson Teaching Fellowship

ERIC Educational Resources Information Center

Woodrow Wilson National Fellowship Foundation, 2016

2016-01-01

The W. K. Kellogg Foundation's Woodrow Wilson Michigan Teaching Fellowship successfully addressed the challenge of preparing and supporting effective teachers for Michigan's high-need classrooms, while helping transform teacher education across the state for the long term. This report analyzes the efforts of the W. K. Kellogg Foundation's Woodrow…

Voice: Reflections on an Artist-Led Program at the Met

ERIC Educational Resources Information Center

Valladares, Maya

2017-01-01

This article explores an education project in which artist Fred Wilson, poets from Lincoln Center's Poet-Linc program, and the Met Museum Education Department collaborated to produce a teen-led spoken-word poetry performance in the Met's galleries. Wilson drew from his own knowledge of the collection to facilitate a group dialogue about objects…

Byron: A Collection of Critical Essays. Twentieth Century Views Series.

ERIC Educational Resources Information Center

West, Paul, Ed.

One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by G. Wilson Knight, Bernard Blackstone, Mario Praz, Paul West, Guy Steffan, F. R. Leavis, W. W. Robson, Helen Gardner, George M. Ridenour, Edmund Wilson, Gilbert Highet, Bertrand Russell, and John Wain--all dealing with the…

Monitoring the Effectiveness of the Wilson Reading System for Students with Disabilities: One District's Example

ERIC Educational Resources Information Center

Stebbins, Molly S.; Stormont, Melissa; Lembke, Erica S.; Wilson, David J.; Clippard, Dana

2012-01-01

The current study detailed the manner in which one school district monitored the effectiveness of the Wilson Reading System for students with disabilities who were experiencing difficulty with reading. Effectiveness was measured by growth in the reading skills that have been documented to be critical for successful readers. Twenty fourth- and…

Insights into Wilson's Warbler migration from analyses of hydrogen stable-isotope ratios

Treesearch

Jeffrey F. Kelly; Viorel Atudorei; Zachary D. Sharp; Deborah M. Finch

2002-01-01

Our ability to link the breeding locations of individual passerines to migration stopover sites and wintering locations is limited. Stable isotopes of hydrogen contained in bird feathers have recently shown potential in this regard. We measured hydrogen stable-isotope ratios (deltaD) of feathers from breeding, migrating, and wintering Wilson's Warblers. Analyses...

Infrared Observations of Comets Halley and Wilson and Properties of the Grains

NASA Technical Reports Server (NTRS)

Hanner, Martha S. (Editor)

1988-01-01

The presented papers and discussions at a workshop held at Cornell Univ. are summarized. The infrared observations of Comet Halley and Comet Wilson are reviewed and they are related to optical properties and composition of cometary grains. Relevant laboratory studies are also discussed. Recommendations are made for future infrared comet observations and supporting laboratory investigations.

The Forest, Not the Tree(s): The Plight of the Generalist

ERIC Educational Resources Information Center

Reinsmith, William A.

2006-01-01

The great naturalist Edward O. Wilson's (1998) recent plea for the "consilience" of knowledge should strike a chord in the heart of every generalist. Invoking the unfinished agenda of the Enlightenment, Wilson has called for a rapprochement among the several branches of learning so that they can be viewed as interrelated and constituting a whole.…

STS-131 crew during SSMTF Ingress/Egress Timeline training

NASA Image and Video Library

2010-02-10

JSC2010-E-024620 (10 Feb. 2010) --- NASA astronaut Stephanie Wilson, STS-131 mission specialist, participates in an ingress/egress timeline training session in a shuttle mock-up in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center. United Space Alliance (USA) instructors David L. Williams (left) and Gary W. Kilgo assisted Wilson.

A Combined MG II/CA II Survey of Stellar Magnetic Activity in the Solar Neighborhood

NASA Technical Reports Server (NTRS)

Wicklund, B. M.; Donahue, R. A.; Dobson, A. K.; Baliunas, Sallie L.

1997-01-01

We use nearly contemporaneus low-resolution IUE observations of Mg II h + k emission and Mount Wilson Observatory Ca II H + K S indices for 33 pairs of observations of lower main sequence stars to formulate a relationship that will permit accurate predictions of S values as a function of (B - V) color and Mg II h + k flux. The resulting relationship is useful because it will extend the set of solar neighborhood stars for which a uniform estimate of chromospheric activity is available to include stars that are not observable from Mount Wilson as well as providing additional estimates of activity levels for stars that are on the Mount Wilson HK Project observing list.

Don Hendrix, master Mount Wilson and Palomar Observatories optician

NASA Astrophysics Data System (ADS)

Osterbrock, Donald E.

2003-06-01

Don O. Hendrix, with at most a high-school education and no previous experience in optics, because an outstanding astronomical optician at Mount Wilson Observatory. He started making Schmidt-camera optics for spectrographs there in 1932, and ultimately made them for all the stellar and nebular spectrographs used at the prime, Newtonian, Cassegrain, and coudé foci of the 60-inch, 100-inch, and Palomar Hale 200-inch telescopes. He completed figuring and polishing the primary 200-inch mirror, and also the Lick Observatory 120-inch primary mirror. Mount Wilson and Palomar Observatory designers Theodore Dunham Jr., Rudolph Minkowski, and Ira S. Bowen led the way for many years in developing fast, effective astronomical spectrographs, based on Hendrix's skills.

An embedding of the universal Askey-Wilson algebra into Uq (sl2) ⊗Uq (sl2) ⊗Uq (sl2)

NASA Astrophysics Data System (ADS)

Huang, Hau-Wen

2017-09-01

The Askey-Wilson algebras were used to interpret the algebraic structure hidden in the Racah-Wigner coefficients of the quantum algebra Uq (sl2). In this paper, we display an injection of a universal analog △q of Askey-Wilson algebras into Uq (sl2) ⊗Uq (sl2) ⊗Uq (sl2) behind the application. Moreover we establish the decomposition rules for 3-fold tensor products of irreducible Verma Uq (sl2)-modules and of finite-dimensional irreducible Uq (sl2)-modules into the direct sums of finite-dimensional irreducible △q-modules. As an application, we derive a formula for the Racah-Wigner coefficients of Uq (sl2).

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

PubMed Central

Chen, Gong; Wang, Huanchen; Robinson, Howard; Cai, Jiwen; Wan, Yiqian; Ke, Hengming

2008-01-01

Selective inhibitors of cyclic nucleotide phosphodiesterase-5 (PDE5) have been used as drugs for treatment of male erectile dysfunction and pulmonary hypertension. An insight into the pharmacophores of PDE5 inhibitors is essential for development of second generation of PDE5 inhibitors, but has not been completely illustrated. Here we report the synthesis of a new class of the sildenafil derivatives and a crystal structure of the PDE5 catalytic domain in complex with 5-(2-ethoxy-5-(sulfamoyl)-3-thienyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one (12). Inhibitor 12 induces conformational change of the H-loop (residues 660–683), which is different from any of the known PDE5 structures. The pyrazolopyrimidinone groups of 12 and sildenafil are well superimposed, but their sulfonamide groups show a positional difference of as much as 1.5 Å. The structure-activity analysis suggests that a small hydrophobic pocket and the H-loop of PDE5 are important for the inhibitor affinity, in addition to two common elements for binding of almost all the PDE inhibitors: the stack against the phenylalanine and the hydrogen bond with the invariant glutamine. However, the PDE5-12 structure does not provide a full explanation to affinity changes of the inhibitors. Thus alternatives such as conformational change of the M-loop are open and further structural study is required. PMID:18346713

Form and function in gene regulatory networks: the structure of network motifs determines fundamental properties of their dynamical state space.

PubMed

Ahnert, S E; Fink, T M A

2016-07-01

Network motifs have been studied extensively over the past decade, and certain motifs, such as the feed-forward loop, play an important role in regulatory networks. Recent studies have used Boolean network motifs to explore the link between form and function in gene regulatory networks and have found that the structure of a motif does not strongly determine its function, if this is defined in terms of the gene expression patterns the motif can produce. Here, we offer a different, higher-level definition of the 'function' of a motif, in terms of two fundamental properties of its dynamical state space as a Boolean network. One is the basin entropy, which is a complexity measure of the dynamics of Boolean networks. The other is the diversity of cyclic attractor lengths that a given motif can produce. Using these two measures, we examine all 104 topologically distinct three-node motifs and show that the structural properties of a motif, such as the presence of feedback loops and feed-forward loops, predict fundamental characteristics of its dynamical state space, which in turn determine aspects of its functional versatility. We also show that these higher-level properties have a direct bearing on real regulatory networks, as both basin entropy and cycle length diversity show a close correspondence with the prevalence, in neural and genetic regulatory networks, of the 13 connected motifs without self-interactions that have been studied extensively in the literature. © 2016 The Authors.

Observations of Upward Propagating Waves in the Transition Region and Corona above Sunspots

NASA Astrophysics Data System (ADS)

Hou, Zhenyong; Huang, Zhenghua; Xia, Lidong; Li, Bo; Fu, Hui

2018-03-01

We present observations of persistent oscillations of some bright features in the upper-chromosphere/transition region above sunspots taken by IRIS SJ 1400 Å and upward propagating quasi-periodic disturbances along coronal loops rooted in the same region taken by the AIA 171 Å passband. The oscillations of the features are cyclic oscillatory motions without any obvious damping. The amplitudes of the spatial displacements of the oscillations are about 1″. The apparent velocities of the oscillations are comparable to the sound speed in the chromosphere, but the upward motions are slightly larger than that of the downward. The intensity variations can take 24%–53% of the background, suggesting nonlinearity of the oscillations. The FFT power spectra of the oscillations show a dominant peak at a period of about 3 minutes, which is consistent with the omnipresent 3 minute oscillations in sunspots. The amplitudes of the intensity variations of the upward propagating coronal disturbances are 10%–15% of the background. The coronal disturbances have a period of about 3 minutes, and propagate upward along the coronal loops with apparent velocities in a range of 30 ∼ 80 km s‑1. We propose a scenario in which the observed transition region oscillations are powered continuously by upward propagating shocks, and the upward propagating coronal disturbances can be the recurrent plasma flows driven by shocks or responses of degenerated shocks that become slow magnetic-acoustic waves after heating the plasma in the coronal loops at their transition-region bases.

Rheological approaches of arteries.

PubMed

Bauer, R D

1984-01-01

A fundamental problem of haemodynamics lies in the description of the rheological properties of arteries. The time and history dependency of stress and strain, the nonlinearity of the stress-radius relationship, and the activity of vascular smooth muscle complicate or even prevent a complete mathematical characterization of the arterial wall mechanics. Due to this nonlinearity, dynamic investigations were hitherto performed in excised arteries in vitro by means of small sinusoidal changes of stress and radius at different stress levels in a wide frequency range. To allow an analysis of the dynamic rheological properties of arteries in vivo, we have developed a procedure which permits the separate determination of the elastic, the viscous, and the inertial forces acting on the arterial wall. The stress can be subdivided into an elastic stress which is a function of radius (r), a viscous stress which is a function of dr/dt, and an inertial stress which is a function of d2r/dt2. These stresses are formulated as polynomials. Under cyclic loading and unloading, hysteresis loops appear in the stress-radius diagrams of arteries. Since the elastic stress-radius diagram must be free from any loop, the coefficients of the viscous and the inertial stress can be found by a fitting procedure, using the criterion of loop elimination. Investigations were performed on exposed canine arteries in vivo. The main result was that the elastic stress-radius curve was markedly nonlinear at greater pulse pressures. The viscous wall behaviour, too, was nonlinear and depended mainly on the square of the vessel radius.

Mechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel.

PubMed

Shabbir, Waheed; Scherbaum-Hazemi, Parastoo; Tzotzos, Susan; Fischer, Bernhard; Fischer, Hendrik; Pietschmann, Helmut; Lucas, Rudolf; Lemmens-Gruber, Rosa

2013-12-01

AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis factor lectin-like domain (TIP domain) sequence, is currently being developed as a treatment for lung edema and has been shown to reduce extravascular lung water and improve lung function in mouse, rat, and pig models. The current paradigm for liquid homeostasis in the adult mammalian lung is that passive apical uptake of sodium via the amiloride-sensitive epithelial Na⁺ channel (ENaC) and nonselective cyclic-nucleotide-gated cation channels creates the major driving force for reabsorption of water through the alveolar epithelium in addition to other ion channels such as potassium and chloride channels. AP301 can increase amiloride-sensitive current in A549 cells as well as in freshly isolated type II alveolar epithelial cells from different species. ENaC is expressed endogenously in all of these cell types. Consequently, this study was undertaken to determine whether ENaC is the specific target of AP301. The effect of AP301 in A549 cells as well as in human embryonic kidney cells and Chinese hamster ovary cells heterologously expressing human ENaC subunits (α, β, γ, and δ) was measured in patch clamp experiments. The congener TIP peptide AP318 [Cyclo(4-aminobutanoic acid-GQRETPEGAEAKPWYD)] activated ENaC by increasing single-channel open probability. AP301 increased current in proteolytically activated (cleaved) but not near-silent (uncleaved) ENaC in a reversible manner. αβγ- or δβγ-ENaC coexpression was required for maximal activity. No increase in current was observed after deglycosylation of extracellular domains of ENaC. Thus, our data suggest that the specific interaction of AP301 with both endogenously and heterologously expressed ENaC requires precedent binding to glycosylated extracellular loop(s).

Liver transplantation for Wilson's disease in pediatric patients: decision making and timing.

PubMed

Narumi, S; Umehara, M; Toyoki, Y; Ishido, K; Kudo, D; Kimura, N; Kobayashi, T; Sugai, M; Hakamada, K

2012-03-01

Transplantation for Wilson's disease occupies 1/3 of the cases for metabolic diseases in Japan. At the end of 2009, 109 transplantations had been performed including three deceased donor cases in the Japanese registry. We herein discuss problems of transplantation for Wilson's disease as well as its indication, timing, and social care. We retrospectively reviewed four fulminant cases and two chronic cases who underwent living donor liver transplantation. There were two boys and two girls. Four adolescents of average age 11.3 years underwent living donor liver transplantation. Duration from onset to transplantation ranged from 10 to 23 days. Average Model for End-stage Liver Disease (MELD) score was 27.8 (range=24-31). All patients were administrated chelates prior to transplantation. MELD, New Wilson's index, Japanese scoring for liver transplantation, and liver atrophy were useful tools for transplantation decision making; however, none of them was an independent decisive tool. Clinical courses after transplantation were almost uneventful. One girl, however, developed an acute rejection episode due to noncompliance at 3 years after transplantation. All patients currently survive without a graft loss. No disease recurrence had been noted even using living related donors. Two adults evaluated for liver transplantation were listed for deceased donor liver transplantation. Both candidates developed cirrhosis despite long-term medical treatment. There were no appropriate living donors for them. There are many problems in transplantation for Wilson's disease. The indications for liver transplantation should be considered individually using some decision-making tools. The safety of the living donor should be paid the most attention. Copyright © 2012 Elsevier Inc. All rights reserved.

Wilson lines in the MHV action

DOE PAGES

Kotko, P.; Stasto, A. M.

2017-09-12

The MHV action is the Yang-Mills action quantized on the light-front, where the two explicit physical gluonic degrees of freedom have been canonically transformed to a new set of fields. This transformation leads to the action with vertices being off-shell continuations of the MHV amplitudes. We show that the solution to the field transformation expressing one of the new fields in terms of the Yang-Mills field is a certain type of the Wilson line. More precisely, it is a straight infinite gauge link with a slope extending to the light-cone minus and the transverse direction. One of the consequences ofmore » that fact is that certain MHV vertices reduced partially on-shell are gauge invariant — a fact discovered before using conventional light-front perturbation theory. We also analyze the diagrammatic content of the field transformations leading to the MHV action. We found that the diagrams for the solution to the transformation (given by the Wilson line) and its inverse differ only by light-front energy denominators. Further, we investigate the coordinate space version of the inverse solution to the one given by the Wilson line. We find an explicit expression given by a power series in fields. We also give a geometric interpretation to it by means of a specially defined vector field. Finally, we discuss the fact that the Wilson line solution to the transformation is directly related to the all-like helicity gluon wave function, while the inverse functional is a generating functional for solutions of self-dual Yang-Mills equations.« less

Wilson lines in the MHV action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kotko, P.; Stasto, A. M.

The MHV action is the Yang-Mills action quantized on the light-front, where the two explicit physical gluonic degrees of freedom have been canonically transformed to a new set of fields. This transformation leads to the action with vertices being off-shell continuations of the MHV amplitudes. We show that the solution to the field transformation expressing one of the new fields in terms of the Yang-Mills field is a certain type of the Wilson line. More precisely, it is a straight infinite gauge link with a slope extending to the light-cone minus and the transverse direction. One of the consequences ofmore » that fact is that certain MHV vertices reduced partially on-shell are gauge invariant — a fact discovered before using conventional light-front perturbation theory. We also analyze the diagrammatic content of the field transformations leading to the MHV action. We found that the diagrams for the solution to the transformation (given by the Wilson line) and its inverse differ only by light-front energy denominators. Further, we investigate the coordinate space version of the inverse solution to the one given by the Wilson line. We find an explicit expression given by a power series in fields. We also give a geometric interpretation to it by means of a specially defined vector field. Finally, we discuss the fact that the Wilson line solution to the transformation is directly related to the all-like helicity gluon wave function, while the inverse functional is a generating functional for solutions of self-dual Yang-Mills equations.« less

Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.

PubMed

Zhang, Shiqiang; Chen, Shen; Li, Wen; Guo, Xiangpeng; Zhao, Ping; Xu, Jianyong; Chen, Yan; Pan, Qiong; Liu, Xiaorong; Zychlinski, Daniela; Lu, Hai; Tortorella, Micky D; Schambach, Axel; Wang, Yan; Pei, Duanqing; Esteban, Miguel A

2011-08-15

Directed hepatocyte differentiation from human induced pluripotent stem cells (iPSCs) potentially provides a unique platform for modeling liver genetic diseases and performing drug-toxicity screening in vitro. Wilson's disease is a genetic disease caused by mutations in the ATP7B gene, whose product is a liver transporter protein responsible for coordinated copper export into bile and blood. Interestingly, the spectrum of ATP7B mutations is vast and can influence clinical presentation (a variable spectrum of hepatic and neural manifestations), though the reason is not well understood. We describe the generation of iPSCs from a Chinese patient with Wilson's disease that bears the R778L Chinese hotspot mutation in the ATP7B gene. These iPSCs were pluripotent and could be readily differentiated into hepatocyte-like cells that displayed abnormal cytoplasmic localization of mutated ATP7B and defective copper transport. Moreover, gene correction using a self-inactivating lentiviral vector that expresses codon optimized-ATP7B or treatment with the chaperone drug curcumin could reverse the functional defect in vitro. Hence, our work describes an attractive model for studying the pathogenesis of Wilson's disease that is valuable for screening compounds or gene therapy approaches aimed to correct the abnormality. In the future, once relevant safety concerns (including the stability of the mature liver-like phenotype) and technical issues for the transplantation procedure are solved, hepatocyte-like cells from similarly genetically corrected iPSCs could be an option for autologous transplantation in Wilson's disease.

Diverse Functional Properties of Wilson Disease ATP7B Variants

PubMed Central

Huster, Dominik; Kühne, Angelika; Bhattacharjee, Ashima; Raines, Lily; Jantsch, Vanessa; Noe, Johannes; Schirrmeister, Wiebke; Sommerer, Ines; Sabri, Osama; Berr, Frieder; Mössner, Joachim; Stieger, Bruno; Caca, Karel; Lutsenko, Svetlana

2012-01-01

BACKGROUND & AIMS Wilson disease is a severe disorder of copper metabolism caused by mutations in ATP7B, which encodes a copper-transporting adenosine triphosphatase. The disease presents with a variable phenotype that complicates the diagnostic process and treatment. Little is known about the mechanisms that contribute to the different phenotypes of the disease. METHODS We analyzed 28 variants of ATP7B from patients with Wilson disease that affected different functional domains; the gene products were expressed using the baculovirus expression system in Sf9 cells. Protein function was analyzed by measuring catalytic activity and copper (64Cu) transport into vesicles. We studied intracellular localization of variants of ATP7B that had measurable transport activities and were tagged with green fluorescent protein in mammalian cells using confocal laser scanning microscopy. RESULTS Properties of ATP7B variants with pathogenic amino-acid substitution varied greatly even if substitutions were in the same functional domain. Some variants had complete loss of catalytic and transport activity, whereas others lost transport activity but retained phosphor-intermediate formation or had partial losses of activity. In mammalian cells, transport-competent variants differed in stability and subcellular localization. CONCLUSIONS Variants in ATP7B associated with Wilson disease disrupt the protein’s transport activity, result in its mislocalization, and reduce its stability. Single assays are insufficient to accurately predict the effects of ATP7B variants the function of its product and development of Wilson disease. These findings will contribute to our understanding of genotype–phenotype correlation and mechanisms of disease pathogenesis. PMID:22240481

Comparison of a modified mid-coronal sectioning technique and Wilson's technique when conducting eye and brain examinations in rabbit teratology studies.

PubMed

Ziejewski, Mary K; Solomon, Howard M; Rendemonti, Joyce; Stanislaus, Dinesh

2015-02-01

There are two methods used when examining fetal rabbit eyes and brain in teratology studies. One method employs prior fixation before serial sectioning (Wilson's technique) and the other uses fresh tissue (mid-coronal sectioning). We modified the mid-coronal sectioning technique to include removal of eyes and brain for closer examination and to increase the number of structures that can be evaluated and compared it to the Wilson's technique. We found that external examination of the head, in conjunction with either sectioning method, is equally sensitive in identifying developmental defects. We evaluated 40,401 New Zealand White (NZW) and Dutch-Belted (DB) rabbit fetuses for external head alterations, of which 28,538 fetuses were further examined for eye and brain alterations using the modified mid-coronal sectioning method (16,675 fetuses) or Wilson's technique (11,863 fetuses). The fetuses were from vehicle control or drug-treated pregnant rabbits in embryo-fetal development studies conducted to meet international regulatory requirements for the development of new drugs. Both methods detected the more common alterations (microphthalmia and dilated lateral cerebral ventricles) and other less common findings (changes in size and/or shape of eye and brain structures). While both methods are equally sensitive at detecting common and rare developmental defects, the modified mid-coronal sectioning technique eliminates the use of chemicals and concomitant fixation artifacts that occur with the Wilson's technique and allows for examination of 100% intact fetuses thereby increasing potential for detecting eye and brain alterations as these findings occur infrequently in rabbits. © 2015 Wiley Periodicals, Inc.

New CCD photometric investigation of the early-type overcontact binary BH Cen in the young star-forming Galactic cluster IC 2944

NASA Astrophysics Data System (ADS)

Zhao, Er-Gang; Qian, Sheng-Bang; Zejda, Miloslav; Zhang, Bin; Zhang, Jia

2018-05-01

BH Cen is a short-period early-type binary with a period of 0.792d in the extremely young star-forming cluster IC 2944. New multi-color CCD photometric light curves in U, B, V, R and I bands are presented and are analyzed by using the Wilson-Devinney code. It is detected that BH Cen is a high-mass-ratio overcontact binary with a fill-out factor of 46.4% and a mass ratio of 0.89. The derived orbital inclination i is 88.9 degrees, indicating that it is a totally eclipsing binary and the photometric parameters can be determined reliably. By adding new eclipse times, the orbital period changes in the binary are analyzed. It is confirmed that the period of BH Cen shows a long-term increase while it undergoes a cyclic oscillation with an amplitude of A 3 = 0.024 d and a period of P 3 = 50.3 yr. The high mass ratio, overcontact configuration and long-term continuous increase in the orbital period all suggest that BH Cen is in the evolutionary state after the shortest-period stage of Case A mass transfer. The continuous increase in period can be explained by mass transfer from the secondary component to the primary one at a rate of Ṁ 2 = 2.8 × 10‑6 M ⊙ per year. The cyclic change can be plausibly explained by the presence of a third body because both components in the BH Cen system are early-type stars. Its mass is determined to be no less than 2.2 M ⊙ at an orbital separation of about 32.5 AU. Since no third light was found during the photometric solution, it is possible that the third body may be a candidate for a compact object.

A New Photometric Investigation of the W UMa-Type Binary BI CVn

NASA Astrophysics Data System (ADS)

Qian, S.-B.; He, J.-J.; Liu, L.; Zhu, L.-Y.; Liao, W. P.

2008-12-01

New photometric observations and their investigation of the W UMa-type binary, BI CVn, are presented. The variations of the orbital period were analyzed based on 12 new determined times of light minimum together with the others compiled from the literature. It is discovered that the period of BI CVn shows a long-term period decrease at a rate of \\dot{P}=-1.51(± 0.12)× {10^{-7}} days year-1 while it undergoes a cyclic variation with a period of 27.0 years and an amplitude of 0fd0151. Photometric solutions determined with the Wilson-Devinney method suggest that BI CVn is a contact binary with a degree of contact of 18.0(±1.7)%. The asymmetry of the light curves was interpreted by the presence of dark spots on both components, and absolute parameters were determined by combining the photometric elements with the spectroscopic solutions given by Lu. The observed period decrease can be plausibly explained by a combination of the mass transfer from the primary to the secondary and angular momentum loss via magnetic braking. The cyclic period oscillation suggests that BI CVn is a triple system containing a tertiary component with a mass no less than 0.58 M sun in a 27.0 year orbit. As in the cases of the other contact binaries (e.g., AH Cnc, AP Leo, AD Cnc, and UX Eri), it is possible that this tertiary companion played an important role for the formation and evolution of the contact system by removing angular momentum from the central system via Kozai oscillation or a combination of Kozai cycle and tidal friction, which causes the eclipsing pair to have a short initial orbital period (e.g., P < 5d). In that case, can the initially detached system evolve into the present contact configuration via a combination of magnetic torques from stellar winds and a case A mass transfer?

The Market Place: An Internal View of the Future of CD-ROM--The Perspective of the H. W. Wilson Company.

ERIC Educational Resources Information Center

Miller, Frank W.; Loeding, Deborah Voigt

1989-01-01

Discussion of technological developments in library reference services focuses on contributions of the H. W. Wilson Company and highlights CD-ROM technology. Topics discussed include online access; menu-driven systems; CD-ROM hardware and software concerns; user response to CD-ROM; quality control of databases; pricing considerations; and future…

Arthropods of native and exotic vegetation and their association with willow flycatchers and Wilson's warblers

Treesearch

Linda S. DeLay; Deborah M. Finch; Sandra Brantley; Richard Fagerlund; Michael D. Means; Jeffrey F. Kelly

1999-01-01

We compared abundance of migrating Willow Flycatchers and Wilson's Warblers to the abundance of arthropods in exotic and native vegetation at Bosque del Apache National Wildlife Refuge. We trapped arthropods using glue-boards in 1996 and 1997 in the same cottonwood, saltcedar, and willow habitats where we mist-netted birds during spring and fall migration. There...

A College that Reinvented Itself: The Wilson College Story

ERIC Educational Resources Information Center

Armacost, Mary-Linda Merriam

2011-01-01

This article presents the story of Wilson College, the only college in the United States where a group of alumnae took the trustees to court over the issue of the announced closing and won the case. The court reversed the trustees' decision on the grounds that the college had failed to seek approval from the court before announcing the change in…

The Nation's Memory: The United States National Archives and Records Administration. An Interview with Don W. Wilson, Archivist of the United States, National Archives and Records Administration.

ERIC Educational Resources Information Center

Brodhead, Michael J.; Zink, Steven D.

1993-01-01

Discusses the National Archives and Records Administration (NARA) through an interview with the Archivist of the United States, Don Wilson. Topics addressed include archival independence and congressional relations; national information policy; expansion plans; machine-readable archival records; preservation activities; and relations with other…

Why Clinical Experience and Mentoring Are Replacing Student Teaching on the Best Campuses. A White Paper

ERIC Educational Resources Information Center

Fraser, James W.; Watson, Audra M.

2014-01-01

Woodrow Wilson Senior Fellow James W. Fraser and Audra Watson, the Foundation's Director of Mentoring and Induction Strategy, take a look at emerging trends in clinical preparation for new teachers. This new white paper is based on experience with the Woodrow Wilson Teaching Fellowships, and includes observations from some of the colleges and…

Values in Higher Education. The Wilson Lecture Series.

ERIC Educational Resources Information Center

Wilson, O. Meredith

The text of a lecture in the University of Arizona Wilson Lecture Series on values in higher education is presented, with responses by Richard H. Gallagher, Jeanne McRae McCarthy, and Raymond H. Thompson. The theme of the talk is that man is by evolution and by necessity a thinking animal, who now finds himself in a technologically dependent…

Biodiversity, functional processes, and the ecological consequences of fragmentation in Southwestern grasslands

Treesearch

Michele Merola-Zwartjes

2004-01-01

Concern over accelerating extinction rates and loss of species diversity on a global scale was the subject of E.O. Wilson's seminal volume Biodiversity (Wilson 1988). This work essentially transformed the term "biodiversity" into a household word as a short-hand for species diversity--or more simply, the full array and variety of living organisms on...

Art as Social Response and Responsibility: Reframing Critical Thinking in Art Education as a Basis for Altruistic Intent

ERIC Educational Resources Information Center

Rolling, James Haywood, Jr.

2013-01-01

Altruism is recognized as "a cultural behavior, well beyond instinctive behavior, and even beyond adaptive social behaviors with respect to evolutionary processes" (Wilson, 1998, p. 29) Yet, if artmaking is a cultural behavior it is one that does not appear at first "to contribute to the survival of the species" (Wilson, 1998,…

The Mount Wilson optical interferometer: The first automated instrument and the prospects for lunar interferometry

NASA Technical Reports Server (NTRS)

Johnston, Ken J.; Mozurkewich, D.; Simon, R. S.; Shao, Michael; Colavita, M.

1992-01-01

Before contemplating an optical interferometer on the Moon one must first review the accomplishments achieved by this technology in scientific applications for astronomy. This will be done by presenting the technical status of optical interferometry as achieved by the Mount Wilson Optical Interferometer. The further developments needed for a future lunar-based interferometer are discussed.

VLA observations of the OH emission from Comet Wilson (1986) - The value of high resolution in both spatial and velocity coordinates

NASA Technical Reports Server (NTRS)

Palmer, Patrick; De Pater, Imke; Snyder, Lewis E.

1989-01-01

In comparison with Comet Halley, the radio OH emission from Comet Wilson behaved very erratically, changing rapidly in position as well as in velocity, while the emission and brightness distribution from Comet Halley displayed apparent stability. A few months later, nearer perihelion, just the opposite behavior was observed at UV wavelengths. Another difference between the two comets is that the OH emission from Comet Halley seemed confined to a region a few times 100.000 km in size, while the emission from Comet Wilson showed up in sporadic blobs, with variable intensities and velocities, at distances as far as 10 to the 6th km from the nucleus. This behavior in Comet Wilson may be associated with the disintegration of the outer frosting associated with new comets and possibly with the fragmentation and ejection of cometesimals from the nucleus. As part of the data analysis, it is demonstrated that lengthening the integration time and lowering the velocity resolution affects the symmetry of the OH images and spectral-line profiles. As a consequence, asymmetric cometary OH line profiles may be more common than previously thought.

Streamflow and water-quality conditions, Wilsons Creek and James River, Springfield area, Missouri

USGS Publications Warehouse

Berkas, Wayne R.

1982-01-01

A network of water-quality-monitoring stations was established upstream and downstream from the Southwest Wastewater-Treatment Plant on Wilsons Creek to monitor the effects of sewage effluent on water quality. Data indicate that 82 percent of the time the flow in Wilsons Creek upstream from the wastewater-treatment plant is less than the effluent discharged from the plant. On October 15, 1977, an advanced wastewater-treatment facility was put into operation. Of the four water-quality indicators measured at the monitoring stations (specific conductance, dissolved oxygen, pH, and water temperature), only dissolved oxygen showed improvement downstream from the plant. During urban runoff, the specific conductance momentarily increased and dissolved-oxygen concentration momentarily decreased in Wilsons Creek upstream from the plant. Urban runoff was found to have no long-term effects on specific conductance and dissolved oxygen downstream from the plant before or after the addition of the advanced wastewater-treatment facility. Data collected monthly from the James River showed that the dissolved-oxygen concentrations and the total nitrite plus nitrate nitrogen concentrations increased, whereas the dissolved-manganese concentrations decreased after the advanced wastewater-treatment facility became operational.