78 FR 77706 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Gemfield Mine...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... gold mine and associated processing and ancillary facilities. The project would be located on public... media, newspapers and the BLM Web site at: http://www.blm.gov/nv/st/en/fo/battle_mountain_field.html... to construct, operate, reclaim, and close an open pit, heap leach, gold mining operation known as the...

78 FR 25096 - Call for Nominations for the Dominguez-Escalante National Conservation Area Advisory Council...

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2013-04-29

..., Grand Junction, CO 81506. Nomination forms may be obtained at the Grand Junction Field Office at the above address, at the BLM Uncompahgre Field Office, 2465 S. Townsend Ave, Montrose, CO 81401, or online at http://www.blm.gov/co/st/en/nca/denca/denca_rmp/DENCA_Resource_Advisory_Council.html . FOR FURTHER...

78 FR 57877 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Maricopa Solar...

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2013-09-20

... Park Project, a photovoltaic (PV) solar power plant with a planned generating capacity of up to 300...; AZA35927] Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Maricopa Solar... site at http://www.blm.gov/az/st/en/prog/energy/solar/maricopa-solar.html . In order to be included in...

76 FR 66747 - Notice of Availability of the Northern Arizona Proposed Withdrawal Final Environmental Impact...

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2011-10-27

... on the Internet at http://www.blm.gov/az/st/en/prog/mining/timeout.html . FOR FURTHER INFORMATION... million acres of Federal locatable minerals in northern Arizona from location and entry under the Mining Law of 1872, (30 U.S.C. 22-54) (Mining Law), subject to valid existing rights, by the Secretary of the...

77 FR 2317 - Notice of Availability of Record of Decision for the Northern Arizona Proposed Withdrawal

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... Plan for the Arizona Strip Field Office and Forest plans for the Kaibab National Forest would be... Internet at http://www.blm.gov/az/st/en/prog/mining/timeout/rod.html . FOR FURTHER INFORMATION CONTACT... General Mining Law 1,006,545 acres of Federal land and interests in land in the vicinity of the Grand...

75 FR 2826 - Airworthiness Directives; Sicma Aero Seat 88xx, 89xx, 90xx, 91xx, 92xx, 93xx, 95xx, and 96xx...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-19

....com ; Internet: http://www.sicma.zodiac.com/en/ . You may review copies of the referenced service... proposed rulemaking (NPRM). SUMMARY: We propose to adopt a new airworthiness directive (AD) for the... aviation product. The MCAI describes the unsafe condition as: Cracks have been found on seats [with...

76 FR 18020 - Airworthiness Directives; Sicma Aero Seat 9140, 9166, 9173, 9174, 9184, 9188, 9196, 91B7, 91B8...

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2011-04-01

... [email protected]zodiac.com ; Internet http://www.sicma.zodiac.com/en/ . (3) You may review copies of the... adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory... identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as...

75 FR 71454 - Meeting of the California Desert District Advisory Council

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2010-11-23

... lands on Friday, December 10, 2010, from 8 a.m. to 5 p.m. and will meet in formal session on Saturday, December 11, 2010, from 8 a.m. to 5 p.m. at the Riverside Marriott, 3400 Market Street, Riverside, CA 92501... BLM California state Web site at http://www.blm.gov/ca/st/en/info/rac/dac.html . SUPPLEMENTARY...

75 FR 26786 - Notice of Public Meeting: Sierra Front-Northwestern Great Basin Resource Advisory Council, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

...), will meet in Winnemucca, Nevada. The meeting is open to the public. Dates and Times: July 13-14, 2010, at the BLM Winnemucca District Office, 5100 E. Winnemucca Blvd., Winnemucca, Nevada. A field trip to..., locations, field trips and meeting times, will be posted on the BLM Web site at: http://www.blm.gov/nv/st/en...

Location-specific expression of chemokines, TNF-α and S100 proteins in a teat explant model.

PubMed

Lind, Monique; Sipka, Anja S; Schuberth, Hans-Joachim; Blutke, Andreas; Wanke, Rüdiger; Sauter-Louis, Carola; Duda, Katarzyna A; Holst, Otto; Rainard, Pascal; Germon, Pierre; Zerbe, Holm; Petzl, Wolfram

2015-04-01

The distal compartments of the udder are the first to interact with invading pathogens. The regulatory and effector functions of two major teat regions [Fürstenberg's rosette (FR); teat cistern (TC)] are largely unknown. The objective of this study was to establish an in vitro model with explants of the FR and the TC to analyse their response towards Escherichia coli LPS and Staphylococcus aureus lipoteichoic acid (LTA). Quantitative stereological analysis confirmed differences in the cellular composition of FR and TC explants. Chemokine (CXCL8, CCL5, CCL20) and TNF-α mRNA were expressed at low levels in both locations. Explant stimulation with LPS increased the mRNA abundance of all tested chemokines and TNF-α. Stimulation with LTA only induced CCL20 and CXCL8. LPS- and LTA-stimulated explant supernatants contained CXCL8 and CXCL3. Supernatants significantly attracted neutrophils in vitro. Compared with TC, the FR showed high constitutive mRNA expression of S100 proteins (A8, A9, A12). In the TC, both LPS and LTA significantly induced S100A8, whereas S100A9 and S100A12 expression was only induced by LPS. The novel model system underpins the role of the teat for recognising pathogens and shaping a pathogen- and location-specific immune response. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

FOREWORD: 4th International Workshop on New Computational Methods for Inverse Problems (NCMIP2014)

NASA Astrophysics Data System (ADS)

2014-10-01

This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 4th International Workshop on New Computational Methods for Inverse Problems, NCMIP 2014 (http://www.farman.ens-cachan.fr/NCMIP_2014.html). This workshop took place at Ecole Normale Supérieure de Cachan, on May 23, 2014. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 and May 2013, (http://www.farman.ens-cachan.fr/NCMIP_2012.html), (http://www.farman.ens-cachan.fr/NCMIP_2013.html). The New Computational Methods for Inverse Problems (NCMIP) Workshop focused on recent advances in the resolution of inverse problems. Indeed, inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational aspects of inversion, Bayesian estimation, Kernel methods, learning methods, convex optimization, free discontinuity problems, metamodels, proper orthogonal decomposition, reduced models for the inversion, non-linear inverse scattering, image reconstruction and restoration, and applications (bio-medical imaging, non-destructive evaluation...). NCMIP 2014 was a one-day workshop held in May 2014 which attracted around sixty attendees. Each of the submitted papers has been reviewed by two reviewers. There have been nine accepted papers. In addition, three international speakers were invited to present a longer talk. The workshop was supported by Institut Farman (ENS Cachan, CNRS) and endorsed by the following French research networks (GDR ISIS, GDR MIA, GDR MOA, GDR Ondes). The program committee acknowledges the following research laboratories: CMLA, LMT, LURPA, SATIE. Eric Vourc'h and Thomas Rodet

76 FR 22830 - Airworthiness Directives; Sicma Aero Seat 88xx, 89xx, 90xx, 91xx, 92xx, 93xx, 95xx, and 96xx...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

... ; Internet http://www.sicma.zodiac.com/en/ . You may review copies of the referenced service information at... earlier NPRM for the products listed above. This action revises the earlier NPRM by expanding the scope.... The MCAI describes the unsafe condition as: Cracks have been found on seats [with] backrest links P/N...

Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey Tail Mushroom).

PubMed

Jeong, Sang-Chul; Yang, Byung-Keun; Kim, Guk-Nam; Jeong, Hun; Wilson, Michael A; Cho, Yip; Rao, K Sundar; Song, Chi-Hyun

2006-01-01

The macrophage-stimulating effect of polysaccharides extracted from Coriolus versicolor (Turkey Tail mushroom) was investigated, and their effectiveness was compared with that of lipopolysaccharide (LPS). The purified polysaccharide (CV-S2-Fr.I) of C. versicolor obtained by Sepharose CL-6B gel chromatography stimulated macrophage lysosomal enzyme activity by 250% at a concentration of 100 microg/mL, which was higher than that of LPS at the same concentration. When CV-S2-Fr.I was used in combination with interferon-gamma, there was a marked cooperative induction of nitric oxide production. However, CV-S2-Fr.I had no effect on nitric oxide production by itself. The proportion of C3-positive macrophages in the CV-S2-Fr.I group increased by 7.2-fold compared with the control group.

Calendar

NASA Astrophysics Data System (ADS)

2004-06-01

JULY 2004 2nd World Congress of the Game Theory Society, Faculty of Luminy, Marseille, France 5-9 July 2004 Europa Organisation (europa@europa-organisation.com), +33 5 34 45 26 45, www.gts2004.org Budapest Workshop on Behavioral Economics, Central European University, Budapest, Hungary 5-10 July 2004 Eva Dotzi (behavecon@ceu.hu), www.iza.org/en/calls_conferences/CallCEU_04.pdf FDA'04. 1st IFAC Workshop on Fractional Differentiation and its Applications, Bordeaux, France 19-20 July 2004 IFAC secretariat (fda04@lap.u-bordeaux1.fr), www.lap.u-bordeaux.fr/fda04/ Bachelier Finance Society Third World Congress, InterContinental Hotel, Chicago, IL, USA 21-24 July 2004 bfs2004@uic.edu, www.uic.edu/orgs/bachelier/ BS/IMS 2004. 6th World Congress of the Bernoulli Society for Mathematical Statistics and Probability, Barcelona, Spain 26-31 July 2004 wc2004@pacifico-meetings.com, +34 93 402 13 85, www.imub.ub.es/events/wc2004 AUGUST 2004 Summer School in Econometrics. The Cointegrated VAR Model: Econometric Methodology and Macroeconomic Applications, Institute of Economics, University of Copenhagen, Denmark 2-22 August 2004 Summerschool@econ.ku.dk, www.econ.ku.dk/summerschool SEPTEMBER 2004 First Bonzenfreies Colloquium on Market Dynamics and Quantitative Economics, Alessandria, Palazzo Borsalino, Italy 9-10 September 2004 colloquium@unipmn.it, www.mfn.unipmn.it/~colloqui/ Risk Analysis 2004. 4th International Conference on Computer Simulation in Risk Analysis and Hazard Mitigation, Aldemar Paradise Royal Mare Hotel, Rhodes, Greece 27-29 September 2004 enquiries@wessex.ac.uk, +44 (0)238 029 3223, www.wessex.ac.uk/conferences/2004/risk04/ OCTOBER 2004 IRC Hedge 2004, InterContinental Hotel, London, UK 10, 11 October 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=10 NOVEMBER 2004 IRC DICE 2004, InterContinental Hotel, London, UK 22, 23 November 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=13 DECEMBER 2004 Quantitative Methods in Finance 2004, Sydney, Australia 15-18 December 2004 Andrea Schnaufer (qmf@uts.edu.au), +61 2 9514 7737, www.business.uts.edu.au/finance/resources/qmf2004/ JANUARY 2005 Developments in Quantitative Finance, Isaac Newton Institute for Mathematical Sciences, Cambridge, UK 24 January-22 July 2005 www.newton.cam.ac.uk/programmes/DQF/index.html

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

PubMed Central

Ruiz, Natividad; Gronenberg, Luisa S.; Kahne, Daniel; Silhavy, Thomas J.

2008-01-01

The outer membrane (OM) of most Gram-negative bacteria contains lipopolysaccharide (LPS) in the outer leaflet. LPS, or endotoxin, is a molecule of important biological activities. In the host, LPS elicits a potent immune response, while in the bacterium, it plays a crucial role by establishing a barrier to limit entry of hydrophobic molecules. Before LPS is assembled at the OM, it must be synthesized at the inner membrane (IM) and transported across the aqueous periplasmic compartment. Much is known about the biosynthesis of LPS but, until recently, little was known about its transport and assembly. We applied a reductionist bioinformatic approach that takes advantage of the small size of the proteome of the Gram-negative endosymbiont Blochmannia floridanus to search for novel factors involved in OM biogenesis. This led to the discovery of two essential Escherichia coli IM proteins of unknown function, YjgP and YjgQ, which are required for the transport of LPS to the cell surface. We propose that these two proteins, which we have renamed LptF and LptG, respectively, are the missing transmembrane components of the ABC transporter that, together with LptB, functions to extract LPS from the IM en route to the OM. PMID:18375759

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.

PubMed

Ruiz, Natividad; Gronenberg, Luisa S; Kahne, Daniel; Silhavy, Thomas J

2008-04-08

The outer membrane (OM) of most Gram-negative bacteria contains lipopolysaccharide (LPS) in the outer leaflet. LPS, or endotoxin, is a molecule of important biological activities. In the host, LPS elicits a potent immune response, while in the bacterium, it plays a crucial role by establishing a barrier to limit entry of hydrophobic molecules. Before LPS is assembled at the OM, it must be synthesized at the inner membrane (IM) and transported across the aqueous periplasmic compartment. Much is known about the biosynthesis of LPS but, until recently, little was known about its transport and assembly. We applied a reductionist bioinformatic approach that takes advantage of the small size of the proteome of the Gram-negative endosymbiont Blochmannia floridanus to search for novel factors involved in OM biogenesis. This led to the discovery of two essential Escherichia coli IM proteins of unknown function, YjgP and YjgQ, which are required for the transport of LPS to the cell surface. We propose that these two proteins, which we have renamed LptF and LptG, respectively, are the missing transmembrane components of the ABC transporter that, together with LptB, functions to extract LPS from the IM en route to the OM.

78 FR 76154 - Allocations, Waivers, and Alternative Requirements for Grantees Receiving Community Development...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

...://www.gpo.gov/fdsys/pkg/FR-2013-03-05/pdf/2013-05170.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-04-19/pdf/2013-09228.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-08-02/pdf/2013-18643.pdf . For grantees receiving...

Optical Signatures of Coupled Quantum Dots

DTIC Science & Technology

2006-02-03

Optical Signatures of Coupled Quantum Dots E. A. Stinaff,1 M. Scheibner,1 A. S . Bracker,1 I. V. Ponomarev,1 V. L. Korenev ,2 M. E. Ware,1 M. F. Doty,1...possibility of optically coupling quantum dots for application in quantum information processing. S emiconductor approaches to quantum information can...REPORTS 3 FEBRUARY 2006 VOL 311 SCIENCE www.sciencemag.org636 o n A ug us t 1 4, 2 00 7 w w w . s ci en ce m ag .o rg D ow nl oa de d fr om Report

Calendar

NASA Astrophysics Data System (ADS)

2004-04-01

MAY 2004 GARP's 3rd Credit & Counterparty Risk Summit, London, UK 21-23 May 2004 Andreas Simou (andreas.simou@garp.com), +44 (0)20 7626 9301, www.garp.com/events/3rdcred IMA Workshop 9: Financial Data Analysis and Applications, University of Minnesota, MN, USA 24-28 May 2004 www.ima.umn.edu/complex/spring/c9.html Global Derivatives & Risk Management 2004, NH Eurobuilding, Madrid, Spain 25-28 May 2004 Aden Watkins, ICBI (awatkins@iirltd.co.uk), +44 (0)20 7915 5198, www.icbi-uk.com/globalderivatives/ WEHIA'04 9th Workshop on Economics and Heterogeneous Interacting Agents, Kyodai-Kaikan, Kyoto, Japan 27-29 May 2004 www.nda.ac.jp/cs/AI/wehia04/ JUNE 2004 Semimartingale Theory and Practice in Finance, Pacific Institute for the Mathematical Sciences, Vancouver, BC, Canada 5-10 June 2004 www.pims.math.ca/birs/workshops/2004/04w5032/ MC2QMC 2004 International Conference on Monte Carlo and Quasi-Monte Carlo Methods, Juan-les-Pins, Côte d'Azur, France 7-10 June 2004 Monique Simonetti (Monique.Simonetti@sophia.inria.fr), +33 4 92 38 78 64, www-sop.inria.fr/omega/MC2QMC2004/ GAIM'04 10th Annual Global Alternative Investment Management Forum, The Beaulieu Centre, Lausanne, Switzerland 8-11 June 2004 +44 (0)20 7915 5103, www.icbi-uk.com/gaim/ 3rd Annual Conference Ri$k Management 2004, Fairmont Hotel, Dubai, United Arab Emirates 12-15 June 2004 www.iirme.com/risk/ 10th Annual Risk USA Congress, Boston, MA, USA 21-24 June 2004 Aristotle Liu (aliu@riskwaters.com), +44 (0)207 484 9700, www.riskusa.com Mannheim Empirical Research Summer School, Mannheim University, Germany 22 June-2 July 2004 oliver@kirchkamp.de, www.sfb504.uni-mannheim.de/merss 9th Annual Conference on Econometric Modelling for Africa, Cape Town, South Africa 30 June-2 July 2004 aesinfo@commerce.uct.ac.za, www.commerce.uct.ac.za/economics/AES2004Conference/ 4th Congress of Nonlinear Analysts. Special Session on Mathematical Methods in Theoretical Finance, Hyatt Grand Cypress Resort, Orlando, FL, USA 30 June-7 July 2004 dkermani@fit.edu, +1 321 674 7412, http://kermani.math.fit.edu/ JULY 2004 2nd World Congress of the Game Theory Society, Faculty of Luminy, Marseille, France 5-9 July 2004 Europa Organisation (europa@europa-organisation.com), +33 5 34 45 26 45, www.gts2004.org Budapest Workshop on Behavioral Economics, Central European University, Budapest, Hungary 5-10 July 2004 Eva Dotzi (behavecon@ceu.hu), www.iza.org/en/calls_conferences/CallCEU_04.pdf FDA'04 1st IFAC Workshop on Fractional Differentiation and its Applications, Bordeaux, France 19-20 July 2004 IFAC secretariat (fda04@lap.u-bordeaux1.fr), www.lap.u-bordeaux.fr/fda04/ Bachelier Finance Society Third World Congress, InterContinental Hotel, Chicago, IL, USA 21-24 July 2004 bfs2004@uic.edu, www.uic.edu/orgs/bachelier/ BS/IMS 2004 6th World Congress of the Bernoulli Society for Mathematical Statistics and Probability, Barcelona, Spain 26-31 July 2004 wc2004@pacifico-meetings.com, +34 93 402 13 85, www.imub.ub.es/events/wc2004 AUGUST 2004 Summer School in Econometrics. The Cointegrated VAR Model: Econometric Methodology and Macroeconomic Applications, Institute of Economics, University of Copenhagen, Denmark 2-22 August 2004 Summerschool@econ.ku.dk, www.econ.ku.dk/summerschool SEPTEMBER 2004 First Bonzenfreies Colloquium on Market Dynamics and Quantitative Economics, Alessandria, Palazzo Borsalino, Italy 9-10 September 2004 colloquium@unipmn.it, www.mfn.unipmn.it/~colloqui/ Risk Analysis 2004. 4th International Conference on Computer Simulation in Risk Analysis and Hazard Mitigation, Aldemar Paradise Royal Mare Hotel, Rhodes, Greece 27-29 September 2004 enquiries@wessex.ac.uk, +44 (0)238 029 3223, www.wessex.ac.uk/conferences/2004/risk04/ OCTOBER 2004 IRC Hedge 2004, InterContinental Hotel, London, UK 10, 11 October 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=10 NOVEMBER 2004 IRC DICE 2004, InterContinental Hotel, London, UK 22, 23 November 2004 enquiries@irc-conferences.com, www.irc-conferences.com/show_conference.php?id=13 DECEMBER 2004 Quantitative Methods in Finance 2004, Sydney, Australia 15-18 December 2004 Andrea Schnaufer (qmf@uts.edu.au), +61 2 9514 7737, www.business.uts.edu.au/finance/resources/qmf2004/

Health Care in Mexico: Is U.S. Partnership/Intervention an Advisable Course of Action?

DTIC Science & Technology

2011-10-26

July 15, 2011, http:// www.imss.gob.mx/ en /institute. html (accessed 4 September 2011). 4 Instituto de Seguridad y Servicios Sociales de los...www.usatoday.com/news/world/2009-08-31- mexico -health-care_N.htm (accessed 4 September 2011). Instituto de Seguridad y Servicios Sociales de los Trabajadores...Seguro Social , Last modified on July 15, 2011, http://www.imss.gob.mx/ en /institute. html (accessed 4 September 2011). 3 access.2 The IMSS, by its

Institute of social justice and medicine: developing a think tank to promote policy formation.

PubMed

Boozary, Andrew; Dugani, Sagar B

2011-10-01

The World Health Organization (WHO) defines health as a "resource for everyday living, not the objective of living"; however, worldwide, there remains an unmistakable inequity in level of health and access to healthcare. The WHO has published documents on financing health systems towards universal health coverage [1], promoting healthy life [2], improving performance of health systems [3], and enriching humanity [4], highlighting our shared responsibility towards improving both national and global health and access to healthcare. These documents also recognize that, despite our local and regional priorities, there is a global desire to develop international strategies to improve healthcare. [1] WHO Report. Health systems financing and the path to universal coverage. 2010. http://www.who.int/bulletin/health_financing/en/index.html [2] WHO Report. Reducing risks, promoting healthy life. 2002. http://www.who.int/whr/2002/en/index.html [3] WHO Bulletin. Health systems: improving performance. 2000. http://www.who.int/whr/2000/en/index.html [4] WHO Bulletin. Conquering suffering, enriching humanity 1997. http://www.who.int/whr/1997/en/index.html.

Immigration Policies in Europe: Impact on Crime -- A Case Study of Germany

DTIC Science & Technology

2008-06-01

2180188,00.html? maca =en-bulletin- 433-html. Accessed 24 Feb 2008. 51 448,000 illegal immigrants up until September 2006 without EU assistance.168 The...asylum. 168 Your Link to Germany. http://www.dw-world.de/dw/article/0,,2180188,00.html? maca =en...for a European Response to Illegal Immigration" 21 September 2006. .http://www.dw- world.de/dw/article/0,,2180188,00.html? maca =en-bulletin-433-html

Transforming Armed Forces to National Guard Units in Latin America

DTIC Science & Technology

2007-03-30

Kliksberg, El crecimiento de la criminalidad en América Latina: un tema urgente, http://www.iadb.org/Etica/SP4321/DocHit.cfm?DocIndex=327, , Internet...html ; Internet accessed Friday, Jan 12, 2007. 4 Ibid. Bernardo Kliksberg, El crecimiento de la criminalidad en América Latina: un tema urgente...Latin American and the Caribbean, page 2, http://www.iadb.org/sds/doc/1073eng.pdf, 6 Ibid. Bernardo Kliksberg, El crecimiento de la criminalidad en

Structural Transitions in Supercoiled Stretched DNA

NASA Astrophysics Data System (ADS)

v, Croquette

1998-03-01

Using magnetic micromanipulation techniques [Strick 96]( uc(T.R.) Strick, J.-F. Allemand, D. Bensimon, A. Bensimon) and uc(V.) Croquette, "The elasticity of a single supercoiled DNA molecule", Science, 271, 1835 (1996)., we have studied the mechanical properties (force versus extension) of single DNA molecules under a wide range of torsional stresses (supercoiling). We show that unwinding the DNA double helix leads to a phase separation between regular B-DNA and denaturation bubbles. The fraction of denatured molecule increases linearly with the degree of unwinding, beginning at a value of 1% unwinding. We have confirmed this denatured state by hybridization of homologous single-stranded DNA probes and by a chemical attack of the exposed bases. Surprisingly, when we overwind the molecule, the elasticity curves we obtain may also be interpreted by the coexistence of two phases, B-DNA and a new phase which we note P-DNA. The fraction of this new phase increases smoothly with overwinding, beginning at 3 % and continuing up to 300 %. Our results indicate that this new phase is four times more twisted that the standard B-DNA and is 1.75 times longer. Although the structure of this phase is not yet known, such a high twisting can only be attained if the sugar-phosphate backbones of the two strands are twisted closely while the bases are expelled outside of the molecule's core, in a structure reminiscent of the one proposed by Pauling. Indeed we have shown that this new phase is sensitive to chemical attack whereas the B-DNA is not. This new phase begins to appear on a molecule overwound by 3 % and stretched by a force of 5 pN, conditions typically encountered in vivo during gene transcription. This new phase may thus play a biological role (for more details).

Lactoferricin mediates Anti-Inflammatory and Anti-Catabolic Effects via Inhibition of IL-1 and LPS Activity in the Intervertebral Disc†

PubMed Central

Kim, Jae-Sung; Ellman, Michael B.; Yan, Dongyao; An, Howard S.; Kc, Ranjan; Li, Xin; Chen, Di; Xiao, Guozhi; Cs-Zabo, Gabriella; Hoskin, David W.; Buechter, D.D.; Van Wijnen, Andre J.; Im, Hee-Jeong

2013-01-01

The catabolic cytokine interleukin-1 (IL-1) and endotoxin lipopolysaccharide (LPS) are well-known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL-1 and LPS may potentially be used to slow or prevent disc degeneration in vivo. Here, we elucidate the striking anti-catabolic and anti-inflammatory effects of bovine lactoferricin (LfcinB) in the intervertebral disc (IVD) via antagonism of both IL-1 and LPS-mediated catabolic activity using in vitro and ex vivo analyses. Specifically, we demonstrate the biological counteraction of LfcinB against IL-1 and LPS-mediated proteoglycan (PG) depletion, matrix-degrading enzyme production and enzyme activity in long-term (alginate beads) and short-term (monolayer) culture models using bovine and human nucleus pulposus (NP) cells. LfcinB significantly attenuates the IL-1 and LPS-mediated suppression of PG production and synthesis, and thus restores PG accumulation and pericellular matrix formation. Simultaneously, LfcinB antagonizes catabolic factor mediated induction of multiple cartilage-degrading enzymes, including MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5, in bovine NP cells at both mRNA and protein levels. LfcinB also suppresses the catabolic factor-induced stimulation of oxidative and inflammatory factors such as iNOS, IL-6, and toll-like receptor-2 (TLR-2) and TLR-4. Finally, the ability of LfcinB to antagonize IL-1 and LPS-mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue, suggesting a potential therapeutic benefit of LfcinB on degenerative disc disease in the future. PMID:23460134

Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc.

PubMed

Kim, Jae-Sung; Ellman, Michael B; Yan, Dongyao; An, Howard S; Kc, Ranjan; Li, Xin; Chen, Di; Xiao, Guozhi; Cs-Szabo, Gabriella; Hoskin, David W; Buechter, Doug D; Van Wijnen, Andre J; Im, Hee-Jeong

2013-09-01

The catabolic cytokine interleukin-1 (IL-1) and endotoxin lipopolysaccharide (LPS) are well-known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL-1 and LPS may potentially be used to slow or prevent disc degeneration in vivo. Here, we elucidate the striking anti-catabolic and anti-inflammatory effects of bovine lactoferricin (LfcinB) in the intervertebral disc (IVD) via antagonism of both IL-1 and LPS-mediated catabolic activity using in vitro and ex vivo analyses. Specifically, we demonstrate the biological counteraction of LfcinB against IL-1 and LPS-mediated proteoglycan (PG) depletion, matrix-degrading enzyme production, and enzyme activity in long-term (alginate beads) and short-term (monolayer) culture models using bovine and human nucleus pulposus (NP) cells. LfcinB significantly attenuates the IL-1 and LPS-mediated suppression of PG production and synthesis, and thus restores PG accumulation and pericellular matrix formation. Simultaneously, LfcinB antagonizes catabolic factor mediated induction of multiple cartilage-degrading enzymes, including MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5, in bovine NP cells at both mRNA and protein levels. LfcinB also suppresses the catabolic factor-induced stimulation of oxidative and inflammatory factors such as iNOS, IL-6, and toll-like receptor-2 (TLR-2) and TLR-4. Finally, the ability of LfcinB to antagonize IL-1 and LPS-mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue, suggesting a potential therapeutic benefit of LfcinB on degenerative disc disease in the future. Copyright © 2013 Wiley Periodicals, Inc.

R-Syst::diatom: an open-access and curated barcode database for diatoms and freshwater monitoring.

PubMed

Rimet, Frédéric; Chaumeil, Philippe; Keck, François; Kermarrec, Lenaïg; Vasselon, Valentin; Kahlert, Maria; Franc, Alain; Bouchez, Agnès

2016-01-01

Diatoms are micro-algal indicators of freshwater pollution. Current standardized methodologies are based on microscopic determinations, which is time consuming and prone to identification uncertainties. The use of DNA-barcoding has been proposed as a way to avoid these flaws. Combining barcoding with next-generation sequencing enables collection of a large quantity of barcodes from natural samples. These barcodes are identified as certain diatom taxa by comparing the sequences to a reference barcoding library using algorithms. Proof of concept was recently demonstrated for synthetic and natural communities and underlined the importance of the quality of this reference library. We present an open-access and curated reference barcoding database for diatoms, called R-Syst::diatom, developed in the framework of R-Syst, the network of systematic supported by INRA (French National Institute for Agricultural Research), see http://www.rsyst.inra.fr/en. R-Syst::diatom links DNA-barcodes to their taxonomical identifications, and is dedicated to identify barcodes from natural samples. The data come from two sources, a culture collection of freshwater algae maintained in INRA in which new strains are regularly deposited and barcoded and from the NCBI (National Center for Biotechnology Information) nucleotide database. Two kinds of barcodes were chosen to support the database: 18S (18S ribosomal RNA) and rbcL (Ribulose-1,5-bisphosphate carboxylase/oxygenase), because of their efficiency. Data are curated using innovative (Declic) and classical bioinformatic tools (Blast, classical phylogenies) and up-to-date taxonomy (Catalogues and peer reviewed papers). Every 6 months R-Syst::diatom is updated. The database is available through the R-Syst microalgae website (http://www.rsyst.inra.fr/) and a platform dedicated to next-generation sequencing data analysis, virtual_BiodiversityL@b (https://galaxy-pgtp.pierroton.inra.fr/). We present here the content of the library regarding the number of barcodes and diatom taxa. In addition to these information, morphological features (e.g. biovolumes, chloroplasts…), life-forms (mobility, colony-type) or ecological features (taxa preferenda to pollution) are indicated in R-Syst::diatom. Database URL: http://www.rsyst.inra.fr/. © The Author(s) 2016. Published by Oxford University Press.

R-Syst::diatom: an open-access and curated barcode database for diatoms and freshwater monitoring

PubMed Central

Rimet, Frédéric; Chaumeil, Philippe; Keck, François; Kermarrec, Lenaïg; Vasselon, Valentin; Kahlert, Maria; Franc, Alain; Bouchez, Agnès

2016-01-01

Diatoms are micro-algal indicators of freshwater pollution. Current standardized methodologies are based on microscopic determinations, which is time consuming and prone to identification uncertainties. The use of DNA-barcoding has been proposed as a way to avoid these flaws. Combining barcoding with next-generation sequencing enables collection of a large quantity of barcodes from natural samples. These barcodes are identified as certain diatom taxa by comparing the sequences to a reference barcoding library using algorithms. Proof of concept was recently demonstrated for synthetic and natural communities and underlined the importance of the quality of this reference library. We present an open-access and curated reference barcoding database for diatoms, called R-Syst::diatom, developed in the framework of R-Syst, the network of systematic supported by INRA (French National Institute for Agricultural Research), see http://www.rsyst.inra.fr/en. R-Syst::diatom links DNA-barcodes to their taxonomical identifications, and is dedicated to identify barcodes from natural samples. The data come from two sources, a culture collection of freshwater algae maintained in INRA in which new strains are regularly deposited and barcoded and from the NCBI (National Center for Biotechnology Information) nucleotide database. Two kinds of barcodes were chosen to support the database: 18S (18S ribosomal RNA) and rbcL (Ribulose-1,5-bisphosphate carboxylase/oxygenase), because of their efficiency. Data are curated using innovative (Declic) and classical bioinformatic tools (Blast, classical phylogenies) and up-to-date taxonomy (Catalogues and peer reviewed papers). Every 6 months R-Syst::diatom is updated. The database is available through the R-Syst microalgae website (http://www.rsyst.inra.fr/) and a platform dedicated to next-generation sequencing data analysis, virtual_BiodiversityL@b (https://galaxy-pgtp.pierroton.inra.fr/). We present here the content of the library regarding the number of barcodes and diatom taxa. In addition to these information, morphological features (e.g. biovolumes, chloroplasts…), life-forms (mobility, colony-type) or ecological features (taxa preferenda to pollution) are indicated in R-Syst::diatom. Database URL: http://www.rsyst.inra.fr/ PMID:26989149

48 CFR 22.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... representative. e98 means the Department of Labor's approved electronic application (http://www.wdol.gov... wage determinations available at http://www.wdol.gov. [53 FR 4935, Feb. 18, 1988, as amended at 71 FR...

48 CFR 22.001 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... representative. e98 means the Department of Labor's approved electronic application (http://www.wdol.gov... wage determinations available at http://www.wdol.gov. [53 FR 4935, Feb. 18, 1988, as amended at 71 FR...

48 CFR 22.001 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... representative. e98 means the Department of Labor's approved electronic application (http://www.wdol.gov... wage determinations available at http://www.wdol.gov. [53 FR 4935, Feb. 18, 1988, as amended at 71 FR...

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

PubMed

Moazed, Farzad; Burnham, Ellen L; Vandivier, R William; O'Kane, Cecilia M; Shyamsundar, Murali; Hamid, Umar; Abbott, Jason; Thickett, David R; Matthay, Michael A; McAuley, Daniel F; Calfee, Carolyn S

2016-12-01

Cigarette smoke exposure is associated with an increased risk of the acute respiratory distress syndrome (ARDS); however, the mechanisms underlying this relationship remain largely unknown. To assess pathways of lung injury and inflammation in smokers and non-smokers with and without lipopolysaccharide (LPS) inhalation using established biomarkers. We measured plasma and bronchoalveolar lavage (BAL) biomarkers of inflammation and lung injury in smokers and non-smokers in two distinct cohorts of healthy volunteers, one unstimulated (n=20) and one undergoing 50 μg LPS inhalation (n=30). After LPS inhalation, cigarette smokers had increased alveolar-capillary membrane permeability as measured by BAL total protein, compared with non-smokers (median 274 vs 208 μg/mL, p=0.04). Smokers had exaggerated inflammation compared with non-smokers, with increased BAL interleukin-1β (p=0.002), neutrophils (p=0.02), plasma interleukin-8 (p=0.003), and plasma matrix metalloproteinase-8 (p=0.006). Alveolar epithelial injury after LPS was more severe in smokers than non-smokers, with increased plasma (p=0.04) and decreased BAL (p=0.02) surfactant protein D. Finally, smokers had decreased BAL vascular endothelial growth factor (VEGF) (p<0.0001) with increased soluble VEGF receptor-1 (p=0.0001). Cigarette smoke exposure may predispose to ARDS through an abnormal response to a 'second hit,' with increased alveolar-capillary membrane permeability, exaggerated inflammation, increased epithelial injury and endothelial dysfunction. LPS inhalation may serve as a useful experimental model for evaluation of the acute pulmonary effects of existing and new tobacco products. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

48 CFR 609.404-70 - Specially Designated Nationals List.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Office of Foreign Assets Control Web site at http://www.treas.gov/ofac/. Contracting officers shall... Web site at http://www.epls.gov. [69 FR 19331, Apr. 13, 2004, as amended at 72 FR 45695, Aug. 15, 2007] ...

48 CFR 609.404-70 - Specially Designated Nationals List.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Office of Foreign Assets Control Web site at http://www.treas.gov/ofac/. Contracting officers shall... Web site at http://www.epls.gov. [69 FR 19331, Apr. 13, 2004, as amended at 72 FR 45695, Aug. 15, 2007] ...

48 CFR 609.404-70 - Specially Designated Nationals List.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Office of Foreign Assets Control Web site at http://www.treas.gov/ofac/. Contracting officers shall... Web site at http://www.epls.gov. [69 FR 19331, Apr. 13, 2004, as amended at 72 FR 45695, Aug. 15, 2007] ...

48 CFR 609.404-70 - Specially Designated Nationals List.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Office of Foreign Assets Control Web site at http://www.treas.gov/ofac/. Contracting officers shall... Web site at http://www.epls.gov. [69 FR 19331, Apr. 13, 2004, as amended at 72 FR 45695, Aug. 15, 2007] ...

48 CFR 609.404-70 - Specially Designated Nationals List.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Office of Foreign Assets Control Web site at http://www.treas.gov/ofac/. Contracting officers shall... Web site at http://www.epls.gov. [69 FR 19331, Apr. 13, 2004, as amended at 72 FR 45695, Aug. 15, 2007] ...

Next-Generation Strategic Communication: Building Influence through Online Social Networking

DTIC Science & Technology

2009-06-01

Millon de  Voces  Marchan en Contra de las FARC,” http://www.eltiempo.com, (accessed April 21, 2009).  11 The Washington Post, “Young Voters Find Voice...Millon de Voces Marchan en Contra de las FARC,” http://www.eltiempo.com, (accessed April 21 2009). Facebook, “Barack Obama,” Facebook, https

FOREWORD: 3rd International Workshop on New Computational Methods for Inverse Problems (NCMIP 2013)

NASA Astrophysics Data System (ADS)

Blanc-Féraud, Laure; Joubert, Pierre-Yves

2013-10-01

Conference logo This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 3rd International Workshop on New Computational Methods for Inverse Problems, NCMIP 2013 (http://www.farman.ens-cachan.fr/NCMIP_2013.html). This workshop took place at Ecole Normale Supérieure de Cachan, in Cachan, France, on 22 May 2013, at the initiative of Institut Farman. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of the ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 (http://www.farman.ens-cachan.fr/NCMIP_2012.html). The NCMIP Workshop focused on recent advances in the resolution of inverse problems. Indeed inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational aspects of inversion, Bayesian estimation, kernel methods, learning methods, convex optimization, free discontinuity problems, metamodels, proper orthogonal decomposition, reduced models for the inversion, non-linear inverse scattering, image reconstruction and restoration, and applications (bio-medical imaging, non-destructive evaluation...). NCMIP 2013 was a one-day workshop held in May 2013 which attracted around 60 attendees. Each of the submitted papers has been reviewed by three reviewers. Among the accepted papers, there are seven oral presentations, five posters and one invited poster (On a deconvolution challenge presented by C Vonesch from EPFL, Switzerland). In addition, three international speakers were invited to present a longer talk. The workshop was supported by Institut Farman (ENS Cachan, CNRS) and endorsed by the following French research networks (GDR ISIS, GDR Ondes, GDR MOA, GDR MSPC). The program committee acknowledges the following research laboratories CMLA, LMT, LSV, LURPA, SATIE. Laure Blanc-Féraud and Pierre-Yves Joubert Workshop co-chair Laure Blanc-Féraud, I3S laboratory and INRIA Nice Sophia-Antipolis, France Pierre-Yves Joubert, IEF, Paris-Sud University, CNRS, France Technical program committee Gilles Aubert, J-A Dieudonné Laboratory, CNRS and University of Nice-Sophia Antipolis, France Nabil Anwer, LURPA, ENS Cachan, France Alexandre Baussard, ENSTA Bretagne, Lab-STICC, France Marc Bonnet, ENSTA, ParisTech, France Antonin Chambolle, CMAP, Ecole Polytechnique, CNRS, France Oliver Dorn, School of Mathematics, University of Manchester, UK Cécile Durieu, SATIE, ENS Cachan, CNRS, France Gérard Favier, I3S Laboratory, University of Nice Sophia-Antipolis, France Mário Figueiredo, Instituto Superior Técnico, Lisbon, Portugal Laurent Fribourg, LSV, ENS Cachan, CNRS, France Marc Lambert, L2S Laboratory, CNRS, SupElec, Paris-Sud University, France Dominique Lesselier, L2S Laboratory, CNRS, SupElec, Paris-Sud University, France Matteo Pastorino, DIBE, University of Genoa, Italy Christian Rey, LMT, ENS Cachan, CNRS, France Simon Setzer, Saarland University, Germany Cedric Vonesch, EPFL, Switzerland Local chair Sophie Abriet, SATIE Laboratory, ENS Cachan, France Béatrice Bacquet, SATIE Laboratory, ENS Cachan, France Lydia Matijevic, LMT Laboratory, ENS Cachan France Invited speakers Jérôme Idier, IRCCyN (UMR CNRS 6597), Ecole Centrale de Nantes, France Massimo Fornasier, Faculty of Mathematics, Technical University of Munich, Germany Matthias Fink, Institut Langevin, ESPCI, Université Paris Diderot, France

78 FR 1832 - Nez Perce-Clearwater National Forests; Id; Crooked River Valley Rehabilitation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-09

... the thirty-fourth through thirty-sixth lines, `` http://www.fs.fed.usinepa/fs-usda-pop.php/?project=40648 '' should read `` http://www.fs.fed.us/nepa/fs-usda-pop.php/?project=40648 ''. [FR Doc. C1-2012...

Security Sector Reform’s Utility in Conflict Prevention

DTIC Science & Technology

2013-12-10

Publications, 1994), 18. 40 Many of these countries in Africa are states in name only due to ill defined borders, fiscal limitations, nomadic ...Security Watch, 12 OCT 2009), Online at http://www.isn.ethz.ch/isn/ Digital -Library/Articles/Detail/?lng= en&id= 108451[accessed on 27 May 2013]. 85...ISN Security Watch, 12 OCT 2009. Online at http://www.isn.ethz.ch/isn/ Digital -Library/Articles/Detail/?lng= en&id= 108451[accessed on 27 May 2013

Carbon Capture and Sequestration (CCS)

DTIC Science & Technology

2009-06-19

tons of CO2 underground each year to help recover oil and gas resources (enhanced oil recovery , or EOR).1 Also, potentially large amounts of CO2 ... CO2 will be used for enhanced gas recovery at a nearby natural gas field. See http://www.vattenfall.com/www/co2_en/ co2_en/Gemeinsame_Inhalte...for enhanced oil recovery (EOR).18 Transporting CO2 in pipelines is similar to transporting petroleum products like natural gas and oil; it requires

78 FR 33103 - Call For Nominations and Comments for the 2013 National Petroleum Reserve in Alaska Oil and Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... available areas is online at http://www.blm.gov/ak . DATES: BLM-Alaska must receive all nominations and...-Alaska Web site at http://www.blm.gov/ak . Authority: 43 CFR 3131.2. Bud Cribley, State Director. [FR Doc...

An Identity of Violence: Exploring the Origins of Political Violence

DTIC Science & Technology

2011-12-01

Incredible Story of Terror Marrakech,” trans. by Google, http://www.lefigaro.fr/international/2011/05/06/01003-20110506ARTFIG00667-l-incroyable- histoire -du...of Terror Marrakech.” trans. by Google. http://www.lefigaro.fr/international/2011/05/06/01003- 20110506ARTFIG00667-l-incroyable- histoire -du

Democratization in Albania: The OSCE, NATO and the European Union

DTIC Science & Technology

2010-06-01

html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). 263 Manuel Montobbio de Balanzo, Spanish Ambassador to Albania, http://www.dw- world.de/dw...article/0,,5259561,00.html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). 264 Reinhard Priebe, The Western Balkan European Perspective, http...world.de/dw/article/0,,5259561,00.html? maca =en-rss-en-all-1573-rdf (accessed 4 March 2010). European Commission Enlargement, Albania – Questions

Albania’s Counter-Terrorism Policy Options: Finding a Strategy of Common Sense

DTIC Science & Technology

2004-06-01

OSCE, February 2004. http://www.osce.org/documents/pia/2004/02/2117_en.pdf ( accessed 20 March 2004). Luarasi, Aleks. Historia e Institucioneve...Terrorism 1999, http://www.state.gov/www/global/terrorism/1999report/europe.html#Albania ( accessed 20 January 2004). 2 terrorism threat, review the...Balkan Stability? Balkan Report, no.153 (Brussels: ICG 25 February 2004). http://www.crisisweb.org/home/index.cfm?id=1239&l=1 ( accessed 10 January

78 FR 18233 - Medical Devices; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... the right column: Section Remove Add 814.20 http://www.fda.gov/ http://www.fda.gov/ cdrh/devadvice.../ PremarketApproval PMA/default.htm. 822.7 http://www.fda.gov/ http://www.fda.gov/ cdrh/ombudsman/ AboutFDA/ dispute.html. CentersOffices/ OfficeofMedicalPr oductsandTobacco/ CDRH/ CDRHOmbudsman/ default.htm. 822.15...

76 FR 22625 - Reporting of Security Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

...) Accessing the Government Printing Office's Web page at http://www.gpoaccess.gov/fr/index.html ; or (3... violations, threat information or criminal activities, vulnerabilities and intelligence was put in place...://data.bls.gov/cgi-bin/print.pl/oes/2009/may/naics2_48-49.htm and http://www.bls.gov/cpi/cpid1012.pdf...

Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

PubMed Central

Zhang, Yali; Wu, Jianzhang; Ying, Shilong; Chen, Gaozhi; Wu, Beibei; Xu, Tingting; Liu, Zhiguo; Liu, Xing; Huang, Lehao; Shan, Xiaoou; Dai, Yuanrong; Liang, Guang

2016-01-01

Acute lung injury (ALI) is a life-threatening acute inflammatory disease with limited options available for therapy. Myeloid differentiation protein 2, a co-receptor of TLR4, is absolutely required for TLR4 sense LPS, and represents an attractive target for treating severe inflammatory diseases. In this study, we designed and synthesized 31 chalcone derivatives that contain the moiety of (E)-4-phenylbut-3-en-2-one, which we consider the core structure of current MD2 inhibitors. We first evaluated the anti-inflammatory activities of these compounds in MPMs. For the most active compound 20, we confirmed that it is a specific MD2 inhibitor through a series of biochemical experiments and elucidated that it binds to the hydrophobic pocket of MD2 via hydrogen bonds with Arg90 and Tyr102 residues. Compound 20 also blocked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration with compound 20 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues. Taken together, the results of this study suggest the specific MD2 inhibitor from chalcone derivatives we identified is a potential candidate for treating acute inflammatory diseases. PMID:27118147

Two years of near real-time observations of the chemical composition of submicron aerosols in Cape Corsica obtained by Q-ACSM

NASA Astrophysics Data System (ADS)

Sciare, Jean; Dulac, François; Crenn, Vincent; Hamonou, Eric; Baisnée, Dominique; Nicolas, José B.; Pont, Véronique; Lambert, Dominique; Gheusi, François; Mallet, Marc; Tison, Emmanuel; Sauvage, Stéphane; Bourrianne, Thierry; Roberts, Gregory; Colomb, Aurélie; Pichon, Jean-Marc; Sellegri, Karine; Savelli, Jean-Luc

2015-04-01

As part of the MISTRALS/ChArMEx (Mediterranean Integrated Studies aT Regional And Local Scales/the Chemistry-Aerosol Mediterranean Experiment; http://www.mistrals-home.org; http://charmex.lsce.ipsl.fr) and the CORSiCA (http://www.obs-mip.fr/corsica) programs, 2-year continuous observations of near real-time chemical composition of submicron aerosols were performed between June 2012 & July 2014 at the Cape Corsica atmospheric supersite (http://gaw.empa.ch/gawsis/reports.asp?StationID=2076203042), a remote marine site in the Western Mediterranean. Submicron organic aerosols (OA) and the major inorganic salts (sulfate, ammonium, nitrate) were monitored every 30 min using a Quadripole Aerosol Chemical Speciation Monitor (Q-ACSM; Aerodyne Res. Inc. MA, USA). Quality control of this large dataset (24-month continuous observations) was performed through closure studies (using co-located SMPS and TEOM-FDMS measurements), direct comparisons with other on-line / off-line instruments running in parallel (filter sampling, OPC, nephelometer …), and large intercomparison of 13 Q-ACSM performed within the EU-FP7 ACTRIS program (http://www.actris.net/). Source apportionment of OA was then performed on a monthly basis using the SourceFinder software (SoFi, http://www.psi.ch/acsm-stations/me-2) allowing the distinction between hydrogen- and oxygen-like organic aerosols (HOA and OOA, respectively). This monthly resolved source apportionment was first compared with co-located real-time tracer measurements (NOx, BC, CO, VOC …) available at the Cape Corsica station. Seasonal patterns of the various properties of (secondary) OOA (OSc, O/C ratio …) were then investigated from monthly resolved source apportionment results (monthly OOA mass spectra) obtained over the period June 2012 - July 2014. Acknowledgements: Atmospheric measurements performed at Cape Corsica Station were funded by CNRS-INSU, ADEME, CEA, and METEO-FRANCE. This work was carried out in the framework of the CORSiCA project funded by the Collectivité Territoriale de Corse through the Fonds Européen de Développement Régional of the European Operational Program 2007-2013 and the Contrat de Plan Etat Région.

Hepatitis B Vaccine: What You Need to Know

MedlinePlus

... información sobre vacunas están disponibles en español y en muchos otros idiomas. Visite www. immunize. org/ vis 1 Why get vaccinated? Hepatitis B is a serious disease that affects the liver. ...

(E)-3-(3,4-Dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one ameliorates the collagen-arthritis via blocking ERK/JNK and NF-κB signaling pathway.

PubMed

Li, Xiuxia; Peng, Fei; Xie, Caifeng; Wu, Wenshuang; Han, Xiaolei; Chen, Lijuan

2013-12-01

Our previous report has shown a natural pyranochalcones-derived compound, (E)-3-(3,4-Dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one (5b), that exerted protection against carrageenan-induced hind paw edema and adjuvant-induced arthritis. In this study, collagen-induced arthritis (CIA) model was used to further examine the anti-arthritic effects of 5b in vivo; the underlying molecular mechanisms of action were also investigated using a murine monocytic cell line, RAW264.7 cells. Here we showed that oral administration of 5b (20mg/kg) significantly suppressed the progression of arthritis. Improvement in disease severity was accompanied by inhibition of CD68-positive cells in knee joint and reduced pro-inflammatory cytokines TNF-α, IL-1β and IL-6 in serum. In vitro, 5b suppressed expressions of iNOS, cyclooxygenase-2 (COX-2), TNF-α, IL-6 and IL-1β as well as productions of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-treated macrophages. This compound also significantly suppressed LPS-induced NF-κB activation, including phosphorylation of I-κB, degradation of I-κB, and nuclear translocation of p65 and p50. Treatment with 5b also blocked LPS-induced expression of TLR4 remarkably, suppressed degradation of IRAKs and phosphorylations of JNK and ERK, but had little effect to p38 kinase activation. These findings indicated that 5b might be a therapeutic agent for rheumatoid arthritis, and exerted an anti-inflammatory effect mainly through mediating TLR4, NF-κB and ERK/JNK signaling pathways in monocytes. © 2013.

77 FR 19745 - WTO Dispute Settlement Proceeding Regarding United States; Anti-Dumping Measures on Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

..., regulations, administrative procedures, practices, and methodologies. That request may be found at www.wto.org... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

78 FR 11725 - WTO Dispute Settlement Proceeding Regarding Indonesia Importation of Horticultural Products...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

... animal products. That request may be found at www.wto.org , contained in a document designated as WT... www.wto.org . Comments open to public inspection may be viewed at www.regulations.gov . Juan Mill...

78 FR 24380 - National Sheep Industry Improvement Center: Notice of Request for Extension and Revision of a...

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2013-04-25

... Service [Doc. No. AMS-LPS-13-0020] National Sheep Industry Improvement Center: Notice of Request for... the currently approved information collection 0581-0263: National Sheep Industry Improvement Center... Division; Livestock, Poultry, and Seed Program; Agricultural Marketing Service; U.S. Department of...

78 FR 78325 - National Research, Promotion, and Consumer Information Programs; Request for Extension and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

...: Title: National Research, Promotion, and Consumer Information Programs. OMB Number: 0581-0093..., filing of petitions and applications and agency #0;statements of organization and functions are examples... Service [Doc.No. AMS-LPS-13-0088] National Research, Promotion, and Consumer Information Programs; Request...

75 FR 73996 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

...:[sol][sol]www.regulations.gov, including any personal information provided, unless the comment includes... http:[sol][sol]www.regulations.gov or e-mail. The http:[sol][sol]www.regulations.gov Web site is an... through http:[sol][sol]www.regulations.gov, your e-mail address will be automatically captured and...

78 FR 3824 - Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... available electronically at http://www.regulations.gov and at http://www.fda.gov/Food/ScienceResearch.... Available at: http://www.fda.gov/Food/ScienceResearch/ResearchAreas/RiskAssessmentSafetyAssessment/default...) Conducted in a Facility Co-Located on a Farm,'' 2012. Available at: http://www.fda.gov/ScienceResearch...

77 FR 58443 - Migratory Bird Hunting; Final Frameworks for Late-Season Migratory Bird Hunting Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... address above, or from the Division of Migratory Bird Management's Web site at http://www.fws.gov... INFORMATION CONTACT or from our Web site at http://www.fws.gov/migratorybirds . Review of Public Comments and... http://www.regulations.gov , or from our Web site at http://www.fws.gov/migratorybirds/NewReports...

77 FR 76165 - WTO Dispute Settlement Proceeding Regarding Argentina-Measures Affecting the Importation of Goods

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... Organization (``WTO Agreement''). That request may be found at www.wto.org contained in a document designated... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

77 FR 49477 - WTO Dispute Settlement Proceeding Regarding United States-Countervailing Measures on Certain Hot...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

... certain hot-rolled carbon steel flat products from India. That request may be found at www.wto.org... World Trade Organization, www.wto.org . Comments open to public inspection may be viewed on the www...

77 FR 26600 - WTO Dispute Settlement Proceeding Regarding United States-Countervailing Measures on Certain Hot...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

... certain hot-rolled carbon steel flat products from India. That request may be found at www.wto.org... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

Present and Future of the United States-Bolivia Relations

DTIC Science & Technology

2009-12-11

Programa de Gobierno-MAS-IPSP,” Archivo Chile , http://www.archivochile.com/Portada/bol_elecciones05/bolelecciones0009.pdf (accessed May 2, 2009...accessed November 9, 2009). Movimiento al Socialismo. “ Programa de Gobierno-MAS-IPSP.” Archivo Chile . http://www.archivochile.com/Portada/bol_elecciones05...partidos en Bolivia,” Futuros Revista Trimestral Latinoamericana y Caribeña de Desarrollo Sustentable, http://www.revistafuturos.info/ futuros_9

77 FR 48193 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... available on the Exchange's Web site at www.nyse.com , at the principal office of the Exchange, on the Commission's Web site at www.sec.gov , and at the Commission's Public Reference Room. II. Self-Regulatory.... 61358 (January 14, 2010), 75 FR 3594 (January 21, 2010) (noting that dark pools and internalizing broker...

77 FR 73732 - WTO Dispute Settlement Proceeding Regarding United States ; Countervailing and Anti-Dumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... below. The panel request may be found at www.wto.org contained in a document designated as WT/DS449/2... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

77 FR 20476 - WTO Dispute Settlement Proceeding Regarding China-Measures Related to the Exportation of Rare...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... www.wto.org contained in a document designated as WT/DS431/ 1. USTR invites written comments from the... World Trade Organization, www.wto.org . Comments open to public inspection may be viewed on the www...

77 FR 57181 - WTO Dispute Settlement Proceeding Regarding United States-Countervailing Duty Measures on Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

...'') on imports of the products from China listed below. The panel request may be found at www.wto.org... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

METEOPOLE-FLUX: an observatory of terrestrial water, energy, and CO2 fluxes in Toulouse

NASA Astrophysics Data System (ADS)

Calvet, Jean-Christophe; Roujean, Jean-Louis; Zhang, Sibo; Maurel, William; Piguet, Bruno; Barrié, Joël; Bouhours, Gilles; Couzinier, Jacques; Garrouste, Olivier; Girres, Sandrine; Suquia, David; Tzanos, Diane

2016-04-01

The METEOPOLE-FLUX project (http://www.cnrm.meteo.fr/spip.php?article874&lang=en) aims at monitoring a large suburban set-aside field in the city of Toulouse (43.572898 N, 1.374384 E). Since June 2012, these data contribute to the international effort to monitor terrestrial ecosystems (grasslands in particular), to the validation of land surface models, and to the near real time quality monitoring of operational weather forecast models. Various variables are monitored at a subhourly rate: wind speed, air temperature, air humidity, atmospheric pressure, precipitation, turbulent fluxes (H, LE, CO2), downwelling and upwelling solar and infrared radiation, downwelling and upwelling PAR, fraction of diffuse incoming PAR, presence of water intercepted by vegetation (rain, dew), soil moisture profile, soil temperature profile, surface albedo, transmissivity of PAR in vegetation canopy. Moreover, local observations are performed using remote sensing techniques: infrared radiometry, GNSS reflectometry, and multi-band surface reflectometry using an aerosol photometer from the AERONET network. Destructive measurements of LAI, green/brown above-ground biomass, and necromass are performed twice a year. This site is characterized by a large fraction of gravels and stones in the soil, ranging from 17% to 35% in the top soil layer (down to 0.6 m), and peaking at 81% at 0.7 m. The impact of gravels and stones on thermal and moisture fluxes in the soil has not been much addressed in the past and is not represented in most land surface models. Their impact on the available water content for plant transpiration and plant growth is not much documented so far. The long term monitoring of this site will therefore improve the knowledge on land processes. The data will be used together with urban meteorological data to characterize the urban heat island. Finally, this site will be used for the CAL/VAL of various satellite products in conjunction with the SMOSMANIA soil moisture network (http://www.cnrm.meteo.fr/spip.php?article251&lang=en). The site will be presented together a first comparison of the ISBA land surface model with the observations.

75 FR 65503 - Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010 Continuum...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

.... ACTION: Notice of technical correction. SUMMARY: On September 20, 2010, HUD posted on http://www.Grants.gov and http://www.hudhre.info its Notice of Funding Availability (NOFA) for HUD's FY2010 Continuum of... http://www.Grants.gov and http://www.hudhre.info a technical correction that corrects Appendix A of the...

75 FR 8698 - Extension of Request for Scientific Views for Draft 2009 Update Aquatic Life Ambient Water...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... following methods: www.regulations.gov : Follow the on-line instructions for submitting comments. E-mail: OW... www.regulations.gov or e-mail. The www.regulations.gov Web site is an ``anonymous access'' system... your comment. If you send an e- mail comment directly to EPA without going through www.regulations.gov...

Exploiting Weaknesses: An Approach to Counter Cartel Strategy

DTIC Science & Technology

2011-12-01

AnimalPolitco, September 24, 2011, http://www.animalpolitico.com/2011/09/tranquilidad- en -frontera-de-tamaulipas-por- construccion -de-base-militar...activities. 140 “Informacion de Ubicaciones Casas de Seguridad , Halcones, Etc. Nuevo Laredo en Vivo,” Mapa nuevolaredoenvivo.es.tl, http...148 “Informacion de Ubicaciones Casas de Seguridad , Halcones, Etc. Nuevo Laredo en Vivo,” Mapa nuevolaredoenvivo.es.tl, http

75 FR 36015 - Uniformed Services Accounts and Death Benefits; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

... http://www.regulations.gov , by mail, by hand deliver/courier, or by facsimile. FOR FURTHER INFORMATION...: Federal Rulemaking Portal: http://www.regulations.gov . Follow the instructions for submitting comments... the exception of redaction of SSNs, profanities, et cetera) on http://www.regulations.gov .'' Dated...

75 FR 33949 - Mandatory Reporting of Greenhouse Gases

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

.... The http://www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will not.../emissions/ghgrulemaking.html . Alternatively, contact Carole Cook at 202-343-9263. Worldwide Web (WWW). In... greenhouse gas reporting rule Web site at http://www.epa.gov/climatechange/emissions/ghgrulemaking.html...

The importance of seminal plasma on the fertility of subsequent artificial inseminations in swine.

PubMed

Rozeboom, K J; Troedsson, M H; Hodson, H H; Shurson, G C; Crabo, B G

2000-02-01

Yorkshire x Landrace sows and gilts were used in a 3x2 factorial arrangement of treatments to determine the effect of uterine inflammation induced by either killed spermatozoa (KS) or bacterial lipopolysaccharide (LPS) on the fertility of a subsequent, optimally timed AI. Estrus was detected with a mature boar twice daily. Twelve hours after the first detection of estrus, females received intrauterine infusions of an inflammatory stimulus consisting of a 100-mL dose of extender containing 3x10(9) KS (n = 40), 20 microg of LPS (n = 40; positive control) or extender alone (n = 40; negative control). An insemination was performed 12 to 18 h later with 3x10(9) motile spermatozoa (i.e., fertile AI) suspended in either 100 mL of seminal plasma (SP; n = 60) or extender replenished with of estrogens (5 microg of estradiol-17beta, 4.5 microg of estrone sulfate, and 2 microg of estrone; n= 60). Transcutaneous ultrasound was performed at the time of fertile AI and again 24 h later to detect the presence or absence of preovulatory follicles. A fertile AI performed within 24 h before ovulation was considered optimal. Conception (CR) and farrowing rates (FR) were greater in females that received a fertile AI diluted with SP compared with extender (P<.01), and there was a significant (P<.05) treatment x fertile AI dilution medium interaction for both CR and FR. Females that received a fertile AI 12 h after infusion of extender had similar CR and FR regardless of fertile AI dilution medium. After inducing an inflammatory response with either KS or LPS, CR and FR were higher in females that received a fertile AI diluted with SP compared with fertile AI dilution with extender (P<.05). The effects of treatment and AI dilution media and their interactions were not significant for litter size in females that farrowed. These results show that the fertility of a subsequent AI can be impaired when semen is deposited into an inflamed environment created by an earlier AI, and this impairment was offset by inclusion of SP in the subsequent insemination.

76 FR 69720 - Northampton Generating Company, L.P.; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-281-000] Northampton Generating Company, L.P.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Northampton Generating Company, L.P.'s application for market-based rate authority, with an accompanying rate...

[Quality of health information about epilepsy on the Internet: Evaluation of French websites].

PubMed

Auvin, S; Dupont, S

2013-03-01

The Internet is now the single largest source of health information and is used by many patients who are affected by epilepsy and their families. To assess the quality of information provided by French website on the different forms of epilepsy and their treatment, we used search engines (French pages from Bing, Google and Yahoo) to look for information using the French equivalent of three keywords epilepsy (Épilepsie); epilepsy treatment (Épilepsie traitement) and seizure (Convulsions). The websites were evaluated for content quality by using an adaptation of the validated DISCERN rating instrument. Each website was evaluated by three investigators (a naive observer, a pediatric neurologist and a neurologist). Most of the information on epilepsy and its treatment were from community websites. We found six French websites which were scored higher than half of the maximal value of our scoring system (≥27.5/55): www.passeportsante.net; fr.wikipedia.org; www.fondation-epilepsie.fr; www.epilepsie-france.fr; www.doctissimo.fr; www.caducee.net. This study provides a list of French websites that have been evaluated for the quality of their information. We did not observe any correlation between the quality of the information and priority on search engine listings. Websites sponsored by patients associations and by institutions should update their content more frequently or work on their search engine indexation to appear higher on search engine listings. Copyright © 2012. Published by Elsevier Masson SAS.

77 FR 8818 - Publication of FY 2011 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... the inventory on the Bureau's Open Government homepage at the following link: http://www.consumerfinance.gov/open/ , specifically at http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix-C-FY2011-Inventory-Data-Summary.pdf and http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix...

75 FR 40857 - Webinar About Advanced Defense Technologies RFP

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... Defense Technologies RFP. Please visit http://www.sba.gov/clusters/index.html for more information. The RFP may be found on http://www.fedbizopps.gov . LOGISTICAL INFORMATION: The webinar will be held on Monday, July 19, 2010. For details, please visit http://www.sba.gov/clusters/index.html . SUPPLEMENTARY...

76 FR 47391 - Mandatory Reporting of Greenhouse Gases

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

...://www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know your... Rule Program Web site http://www.epa.gov/climatechange/emissions/ghgrulemaking.html . To submit a.../ghgrulemaking.html . Alternatively, contact Carole Cook at 202-343-9263. Worldwide Web (WWW). In addition to...

75 FR 57956 - Draft Revision of the Federalwide Assurance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

...:[sol][sol]www.hhs.gov/ohrp/assurances/assurances_index.html. OHRP will consider comments received...:[sol][sol]www.regulations.gov. Enter the above docket ID number in the ``Enter Keyword or ID'' field... received, including any personal information, will be posted without change to http:[sol][sol]www...

77 FR 30439 - Proposed Establishment of Class E Airspace; Apopka, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... through the Internet at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION CONTACT: John Fornito...:[sol][sol]www.regulations.gov. Persons wishing the FAA to acknowledge receipt of their comments on this... http:[sol][sol]www.regulations.gov. Recently published rulemaking documents can also be accessed...

76 FR 38585 - Proposed Establishment of Class E Airspace; Wilkes-Barre, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... may also submit and review received comments through the Internet at http:[sol][sol]www.regulations... submit comments through the Internet at http:[sol][sol]www.regulations.gov. Annotators wishing the FAA to... downloaded from and comments submitted through http:[sol][sol]www.regulations.gov. Recently published...

75 FR 73015 - Proposed Amendment of Class E Airspace; Newport, VT

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... comments through the Internet at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION CONTACT...:[sol][sol]www.regulations.gov. Commenters wishing the FAA to acknowledge receipt of their comments on... submitted through http:[sol][sol]www.regulations.gov. Recently published rulemaking documents can also be...

78 FR 32212 - Proposed Amendment of Class E Airspace; Factoryville, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... received comments through the Internet at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION... comments through the Internet at http:[sol][sol]www.regulations.gov. Persons wishing the FAA to acknowledge... from and comments submitted through http:[sol][sol]www.regulations.gov. Recently published rulemaking...

76 FR 52297 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...: http:[sol][sol]www.regulations.gov. Follow the instructions for submitting comments. [cir] E-mail... without change to http:[sol][sol]www.regulations.gov, including any personal information provided. To confirm receipt of your comment, please check http:[sol][sol]www.regulations.gov approximately two to...

78 FR 32213 - Proposed Amendment of Class E Airspace; Bedford, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION CONTACT: John Fornito, Operations... for address and phone number). You may also submit comments through the Internet at http:[sol][sol]www...:[sol][sol]www.regulations.gov. Recently published rulemaking documents can also be accessed through the...

75 FR 73016 - Proposed Establishment of Class E Airspace; Kenbridge, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... the Internet at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION CONTACT: Richard Horrocks...:[sol][sol]www.regulations.gov. Comments wishing the FAA to acknowledge receipt of their comments on... comments submitted through http:[sol][sol]www.regulations.gov. Recently published rulemaking documents can...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

76 FR 45577 - Clinical Investigator Training Course

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-29

... course at the registration/ information Web site at https://www.trialstransformation.org/fda-clinical... be made at https://www.supportnlc.org/Room_Reservations.html or by calling 301-431-6400. FDA has... information, and a detailed description of the course can be found at https://www.trialstransformation.org/fda...

78 FR 24290 - Furlough Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... specific information, please see the FAA Web site at http://www.faa.gov/about/office_org/headquarters...://www.faa.gov/about/office_org/headquarters_offices/avs/operations_sequestration . Issued in Washington...

77 FR 61818 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping and Countervailing Duties...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... certain automobiles from the United States. That request may be found at www.wto.org in a document... China. That request may be found at www.wto.org contained in a document designated as WT/DS440/1. The... Organization, www.wto.org . Comments open to public inspection may be viewed on the www.regulations.gov Web...

NUREBASE: database of nuclear hormone receptors.

PubMed

Duarte, Jorge; Perrière, Guy; Laudet, Vincent; Robinson-Rechavi, Marc

2002-01-01

Nuclear hormone receptors are an abundant class of ligand activated transcriptional regulators, found in varying numbers in all animals. Based on our experience of managing the official nomenclature of nuclear receptors, we have developed NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. The reviewed NUREBASE is completed by NUREBASE_DAILY, automatically updated every 24 h. Both databases are organized under a client/server architecture, with a client written in Java which runs on any platform. This client, named FamFetch, integrates a graphical interface allowing selection of families, and manipulation of phylogenies and alignments. NUREBASE sequence data is also accessible through a World Wide Web server, allowing complex queries. All information on accessing and installing NUREBASE may be found at http://www.ens-lyon.fr/LBMC/laudet/nurebase.html.

75 FR 39710 - Postal Classification Change

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

.... ADDRESSES: Submit comments electronically via the Commission's Filing Online system at http:[sol][sol]www... the Commission's Web site (http:[sol][sol]www.prc.gov). Proposed edits to the draft Mail...

A Counter Insurgency Study: An Analysis of Local Defenses

DTIC Science & Technology

2004-09-01

Derrota de Sendero Luminoso; Programa Institucional de Investigación y Proyeccion en el Area de Gobernabilidad y Politica Publica, IEP ediciones...Corporation, Santa Monica CA. Kruijt, D. (1996), Sociedad de Terror: Guerrillas y Contrainsurgencia en Guatemala y El Peru; Cuadcien, Programa ... en El Salvador (1981 – 1992); Centro de Paz, El Latinoamericano; Retrieved on 7/16/2004 from http://www.stormpages.com/marting/laguerrasalvador.htm

Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial.

PubMed

Rittig, N; Bach, E; Thomsen, H H; Johannsen, M; Jørgensen, J O; Richelsen, B; Jessen, N; Møller, N

2016-04-01

Inflammation is catabolic and causes muscle loss. It is unknown if amino acid supplementation reverses these effects during the acute phase of inflammation. The aim was to test whether amino acid supplementation counteracts endotoxin-induced catabolism. Eight young, healthy, lean males were investigated three times in randomized order: (i) normal conditions (Placebo), (ii) endotoxemia (LPS), and (iii) endotoxemia with amino acid supplementation (LPS + A). Protein kinetics were determined using phenylalanine, tyrosine, and urea tracers. Each study day consisted of a four-hour non-insulin stimulated period and a two-hour hyperinsulinemic euglycemic clamp period. Muscle biopsies were collected once each period. Endotoxin administration created a significant inflammatory response (cytokines, hormones, and vital parameters) without significant differences between LPS and LPS + A. Whole body protein breakdown was elevated during LPS compared with Placebo and LPS + A (p < 0.05). Whole body protein synthesis was higher during LPS + A than both Placebo and LPS (p < 0.003). Furthermore, protein synthesis was higher during LPS than during Placebo (p < 0.02). Net muscle phenylalanine release was markedly decreased during LPS + A (p < 0.004), even though muscle protein synthesis and breakdown rates did not differ significantly between interventions. LPS + A increased mammalian target of rapamycin (mTOR) phosphorylation (p < 0.05) and eukaryotic translation factor 4E-binding protein 1 (4EBP1) phosphorylation (p = 0.007) without activating AMPK or affecting insulin signaling through Akt. During insulin stimulation net muscle phenylalanine release and protein degradation were further reduced. Amino acid supplementation in the acute phase of inflammation reduces whole body and muscle protein loss, and this effect is associated with activation of mTOR and downstream signaling to protein synthesis through mTORC1, suggesting a therapeutic role for intravenous amino acids in inflammatory states. The Central Denmark Region Ethics Commitee (1-10-71-410-12) www.clinicaltrials.gov (identification number NCT01705782). Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

76 FR 55390 - Guidance on Exculpatory Language in Informed Consent, Draft

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-07

...://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/default.htm , is intended to assist... , http://www.hhs.gov/ohrp/newsroom/rfc/index.html , or http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/default.htm . III. Request for Comments OHRP and FDA are making their joint draft...

77 FR 61608 - Public Meeting of the Presidential Commission for the Study of Bioethical Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-10

[email protected]bioethics.gov . Additional information may be obtained at www.bioethics.gov . SUPPLEMENTARY... also be webcast at www.bioethics.gov . Under authority of Executive Order 13521, dated November 24... access to the webcast, will be available at www.bioethics.gov . The Commission welcomes input from anyone...

78 FR 42910 - Community Right-to-Know; Adoption of 2012 North American Industry Classification System (NAICS...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system...-7672, http://www.epa.gov/epaoswer/hotline/ . SUPPLEMENTARY INFORMATION: I. Why is EPA issuing this... entity, consult the person listed in the FOR FURTHER INFORMATION CONTACT section. III. What should I...

75 FR 70956 - Post Office Closing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... electronically via the Commission's Filing Online system at http:[sol][sol]www.prc.gov. Those who cannot submit... supporting material on its Web site at http:[sol][sol]www.prc.gov. Additional filings in this case and...) pursuant to Commission rules 9(a) and 10(a) at the Commission's Web site, http:[sol][sol]www.prc.gov...

75 FR 70965 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... rulemaking Web site: Go to http:[sol][sol]www.regulations.gov and follow the instructions for sending your.... Privacy: We will post all comments we receive, without change, to http:[sol][sol]www.regulations.gov... 19477-78). Docket: To read background documents or comments received, go to http:[sol][sol]www...

77 FR 75195 - Notice of a Virtual Meeting of the Advisory Committee on Apprenticeship (ACA)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... Office of Apprenticeship's (OA) homepage: http://www.doleta.gov/oa/ . The ACA is a discretionary... will be prominently posted on the OA homepage: http://www.doleta.gov/oa/ . Members of the public are... OA's homepage: http://www.doleta.gov/oa/ . All meeting participants, whether attending virtually or...

76 FR 57023 - National Sea Grant Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-15

... Grant College Program Web site at http://www.seagrant.noaa.gov/leadership/advisory_board.html . DATES... advice. The agenda for this meeting can be found at http://www.seagrant.noaa.gov/leadership/advisory...

75 FR 59697 - National Sea Grant Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... Grant College Program Web site at http://www.seagrant.noaa.gov/leadership/advisory_board.html . DATES... advice. The agenda for this meeting can be found at http://www.seagrant.noaa.gov/leadership/advisory...

76 FR 47538 - Sacred Sites; Executive Order 13007

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... is available for review and comment at http://www.fs.fed.us/spf/tribalrelations/sacredsites . DATES.... The draft report, and other associated information, is available at: http://www.fs.fed.us/spf...

77 FR 70160 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... Availability Responsible Agency: Office of Federal Activities, General Information (202) 564-7146 or http://www... available at: http://www.epa.gov/compliance/nepa/eisdata.html . SUPPLEMENTARY INFORMATION: As of October 1...

75 FR 34481 - Agency Form Submitted to OMB for Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

... posted on the Commission's Internet server at http://www.usitc.gov/intellectual_property or may be..., general information about the Commission can be obtained from its Internet server ( http://www.usitc.gov...

76 FR 4299 - National Sea Grant Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... on the National Sea Grant College Program Web site at http://www.seagrant.noaa.gov/leadership... can be found at http://www.seagrant.noaa.gov/leadership/advisory_board.html . Dated: January 19, 2011...

78 FR 9781 - Airworthiness Directives; Pacific Aerospace Limited Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

...: +64 7 843 6134; email: [email protected]nz ; Internet: http://www.aerospace.co.nz/ . You may...; email: [email protected]nz ; Internet: http://www.aerospace.co.nz/ . (4) You may view this service...

76 FR 12817 - National Consumer Protection Week, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... abusive companies accountable and shifting the balance of power back to the American consumer. I was proud... the knowledge to manage their finances more effectively by visiting www.MyMoney.gov and www.Consumer...

77 FR 20497 - National Financial Capability Month, 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-05

... their financial future. I encourage all Americans to take advantage of the free, reliable financial resources at www.MyMoney.gov , www.ConsumerFinance.gov , and 1-888-MyMoney. NOW, THEREFORE, I, BARACK OBAMA...

10 CFR 431.133 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... Fairfax Dr., Suite 200, Arlington, VA 22203 or http://www.ari.org/std/standards.htm. (ii) Anyone can..., Atlanta, GA 30329, (404) 636-8400, or http://www.ashrae.org. [71 FR 71372, Dec. 8, 2006] ...

75 FR 64752 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

76 FR 13676 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

76 FR 13438 - Amended Columbia River Basin Fish and Wildlife Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... Council's Web site at http://www.nwcouncil.org/fw/program and then, for the subbasin plan elements and relevant decision documents in particular, at http://www.nwcouncil.org/fw/subbasinplanning/Default.htm...

78 FR 49596 - Order 1050.1F Environmental Impact: Policies and Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

...: Policies and Procedures is available at http://www.faa.gov/about/office_org/headquarters_ offices/apl... categorical exclusion justification package is available at http://www.faa.gov/about/office_org/headquarters...

76 FR 7629 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... open to the public via live webcast at http://www.whitehouse.gov/live . DATES: The meeting will be held... posted on the White House website ( http://www.whitehouse.gov ) without change, including any business or... the internet via live webcast at http://www.whitehouse.gov/live . The purpose of this meeting is to...

77 FR 47287 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

..., is available either electronically through http://www.regulations.gov or in hard copy at the OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the online instructions for...

77 FR 2098 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... Subcommittee Report. A copy of the agenda for the meeting will be available at http://www.nrc.gov/reading-rm/doc-collections/acmui/agenda . Handouts for the meeting will be available at http://www.nrc.gov... will be available on the ACMUI's web site ( http://www.nrc.gov/reading-rm/doc-collections/acmui/tr...

75 FR 40864 - Notice of Fiscal Year 2010 Border Grant Funding and Solicitation for Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... Federal Grant Web site, http://www.grants.gov . Eligible projects for funding with BEG are identified in... applications for BEG funding at the Federal Grant Web site, http://www.grants.gov . FOR FURTHER INFORMATION... the MOE explanation, http://www.fmcsa.dot.gov/safety-security/grants/beg/moe.aspx . The Border...

75 FR 22736 - Notice of Request for Applications for the Veterinary Medicine Loan Repayment Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... (RFA) at http://www.nifa.usda.gov/vmlrp . DATES: The FY 2010 Veterinary Medicine Loan Repayment Program (VMLRP) application package has been made available at http://www.nifa.usda.gov/vmlrp and applications... http://www.nslds.ed.gov . Individuals who consolidated their DVM loans with non-educational loans or...

75 FR 67392 - Notice of Availability: HUD's Fiscal Year (FY) NOFA for the Choice Neighborhoods Initiative-Round...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

..., HUD. ACTION: Notice extension of deadline. SUMMARY: On August 26, 2010, HUD posted on http://www...--Round 1. Today's Federal Register notice announces that HUD has posted on http://www.Grants.gov a... to the Mapping Tool used to determine neighborhood eligibility. HUD will post on http://www.Grants...

76 FR 578 - Notice of Funding Availability (NOFA) for Fiscal Year 2010; Rural Innovation Fund Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

.... SUMMARY: On December 22, 2010, HUD posted on http://www.Grants.gov its Notice of Funding Availability... publication announces that HUD has posted on http://www.Grants.gov a technical correction that, most... Fund grant.'' The revised NOFA can be found and downloaded from http://www.Grants.gov , using the CFDA...

78 FR 57457 - Notice of Funds Availability Inviting Applications for Grants for Transportation of Veterans in...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

..., VA announced that a copy of the Application Package can be downloaded directly from `` http://www.ruralhealth.va.gov/coordination-pilot/index.asp ''. It should have read, `` http://www.grants.gov/web/grants... CONTACT heading, remove `` http://www.ruralhealth.va.gov/coordination-pilot/index.asp '' and add, in its...

75 FR 40856 - Federal Register Meeting Notice; Webinar About Regional Innovation Clusters RFP

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... potential Offerors about the Regional Innovation Clusters RFP. For more information please go to http://www.sba.gov/clusters/index.html . The RFP may be found on http://www.fedbizopps.gov . Logistical Information: The webinar will be held on Thursday, July 15, 2010. For details, please visit http://www.sba.gov...

76 FR 61478 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

.... Eastern Time. The meeting will be open to the public via live Webcast at http://www.whitehouse.gov/live... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information... meeting will be broadcast on the internet via live Webcast at http://www.whitehouse.gov/live . The purpose...

75 FR 59322 - Notice of Availability of Answers to Frequently Asked Questions Regarding Buy America & FRA's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... Asked Questions can be found on FRA's Web site at http://www.fra.dot.gov/Pages/11.shtml . DATES: Written... electronic site at http://www.regulations.gov . Commenters should follow the instructions below for mailed and hand-delivered comments. (1) Web Site: http://www.regulations.gov . Follow the instructions for...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

78 FR 16857 - Office of the Assistant Secretary for Financial Resources, Office of Grants and Acquisition...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... Inventory.'' The following should be changed: The notice provided an incorrect URL address: http://www.hhs.gov/grants/servicecontractsfy11.html . The correct URL address is as follows: http://www.hhs.gov... following URL address: http://www.hhs.gov/grants/servicecontractsfy11.html . Change the fiscal year to FY...

76 FR 16629 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-24

... other FTR Bulletins can be found at http://www.gsa.gov/ftrbulletin . The RIT allowance tables are located at http://www.gsa.gov/relocationpolicy . DATES: This notice is effective March 24, 2011. FOR... CFR part 301-17 Appendices A through D. The tables will be published at http://www.gsa.gov...

77 FR 32621 - Developing Large-Scale Renewable Energy Projects at Federal Facilities Using Private Capital Draft

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... consider comments and recommendations on the draft guidebook, which is available at: http://www1.eere... draft guidebook is available at: http://www1.eere.energy.gov/femp/pdfs/largereguide.pdf . DOE will... DATES section. More information on DOE's FEMP is available at: http://www1.eere.energy.gov/femp...

76 FR 31680 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... p.m. Eastern Time. The meeting will be open to the public via live webcast at http://www.whitehouse... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information.... The meeting will be broadcast on the internet via live webcast at http://www.whitehouse.gov/live . The...

76 FR 70412 - Smart Grid Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... recommendations that the Committee will consider at the meeting will be posted on the SGAC Web site at http://www... posted on the Smart Grid Web site at http://www.nist.gov/smartgrid . DATES: The SGAC will hold a meeting... (5 U.S.C. App.). Background information on the Committee is available at http://www.nist.gov...

75 FR 57107 - Open Meeting of the President's Economic Recovery Advisory Board (the PERAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... live webcast at http://www.whitehouse.gov/live . DATES: The meeting will be held on October 4, 2010 at... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information... via live webcast at http://www.whitehouse.gov/live . The purpose of this meeting is to continue...

75 FR 816 - Identification of Additional Classes of Facilities for Development of Financial Responsibility...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... protected through www.regulations.gov or e-mail. The www.regulations.gov Web site is an ``anonymous access... Can I Get Copies of This Document and Other Related Information? This Federal Register notice and.... EPA-HQ-SFUND-2009-0834. All documents in the docket are listed on the http://www.regulations.gov Web...

78 FR 38027 - Wilkesboro Hydroelectric Company, LLC; Wilkesboro Hydropower, LLC; Notice of Application for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... viewed or printed on the eLibrary link of Commission's Web site at http://www.ferc.gov/docs-filing... Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp . Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http://www.ferc...

77 FR 22328 - Guidance for Industry on the Judicious Use of Medically Important Antimicrobial Drugs in Food...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... electronic comments on the guidance to http:[sol][sol]www.regulations.gov. Submit written comments to the... at either http:[sol][sol]www.fda.gov/AnimalVeterinary/ GuidanceComplianceEnforcement/GuidanceforIndustry/default.htm or http:[sol][sol]www.regulations.gov. Dated: April 5, 2012. David Dorsey, Acting...

75 FR 32533 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping Measures on Certain Shrimp...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... should be submitted electronically to http:[sol][sol] www.regulations.gov , docket number USTR-2010-0008. If you are unable to submit comments using http:[sol][sol] www.regulations.gov , please contact Sandy.... Persons may submit public comments electronically to http:[sol][sol] www.regulations.gov docket number...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

77 FR 62264 - Notice of a Virtual Meeting of the Advisory Committee on Apprenticeship (ACA)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... from the Office of Apprenticeship's (OA) homepage: http://www.doleta.gov/oa/ . The ACA is a... instructions to participate in this meeting will be prominently posted on the OA homepage: http://www.doleta... meeting. All meeting updates will be posted to OA's homepage: http://www.doleta.gov/oa/ . All meeting...

75 FR 6688 - Section 8 Housing Assistance Payments Program-Renewal Funding Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... were published in a separate notice which can be viewed at: http://www.huduser.org/portal/datasets/aaf... be available electronically from the HUD data information page at http://www.huduser.org/portal... overview and in the FMR documentation at http://www.HUDUSER.org . In this publication, the rent and utility...

Effect of Three-spot Seahorse Petroleum Ether Extract on Lipopolysaccharide Induced Macrophage RAW264.7 Inflammatory Cytokine Nitric Oxide and Composition Analysis.

PubMed

Chen, LiPing; Shen, XuanRi; Chen, GuoHua; Cao, XianYing; Yang, Jian

2015-01-01

Three-Spot seahorse is a traditional medicine in Asian countries. However, the alcohol extract is largely unknown for its anti-inflammatory activity. This study aimed at elucidating fraction of potent anti-inflammatory activity of seahorse. A systematic solvent extraction method of liquid-liquid fractionation of ethanol crude extract gave four fractions petroleum ether (PE), and ethyl acetate (EtOAc), water saturated butanol (n-BuOH), water (H2O). In this study, PE extract was selected for further study after preliminary screening test, and was connected to silica column chromatography and eluted with different polarity of mobile phases, and obtained four active fractions (Fr I, Fr II, Fr III, Fr IV). Effect of separated fractions on inflammation was investigated in lipopolysaccharide (LPS) stimulated murine RAW264.7 cells in vitro. The result shows that seahorse extract was capable of inhibiting the production of nitric oxide (NO) significantly in a dose dependent manner and exhibited no notable cytotoxicity on cell viability. IC50 of fraction IV was 36.31 μg/mL, indicating that separated fraction possessed potent NO inhibitory activity against LPS-induced inflammatory response, thus, demonstrated its in vitro anti-inflammatory potentiality, it may be at least partially explained by the presence of anti-inflammation active substances, phenolic compounds, phospholipids and polyunsaturated fatty acids, especially phospholipids and polyunsaturated fatty acids. It could be suggested that seahorse lipid-soluble components could be used in functional food and anti-inflammatory drug preparations.

75 FR 54889 - Development of Set 24 Toxicological Profiles

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... these documents will be available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html . Set 24... toxicological profiles for each substance included on the Priority List of Hazardous Substances ( http://www...

75 FR 76482 - Federal Housing Administration (FHA): FHA Maximum Loan Limits for 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... http://www.hud.gov/offices/adm/hudclips/letters/mortgagee/ . FOR FURTHER INFORMATION CONTACT: Karin B... be found at http://www.hud.gov/offices/adm/hudclips/letters/mortgagee/ mortgagee/. Dated: November 29...

75 FR 63865 - National Science Board; Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... the National Science Board Web site http:[sol][sol]www.nsf.gov/nsb for additional information and schedule updates (time, place, subject matter or status of meeting) may be found at http:[sol][sol]www.nsf...

77 FR 24711 - Agency Information Collection Activities: Proposed Collection Renewal; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... methods: http://www.FDIC.gov/regulations/laws/federal/notices.html Email: [email protected] Include the...: http:// www.fdic.gov/regulations/laws/federal/notices.html. Request for Comment Comments are invited on...

75 FR 29466 - Prohibition Against Certain Flights Within the Territory and Airspace of Afghanistan

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... access to and the use of intelligence; Operational security (OPSEC), including handling, storage, and...://www.faa.gov/regulations_policies or Accessing the Government Printing Office's Web page at: http://www...

Effects of helium and air inhalation on the innate and early adaptive immune system in healthy volunteers ex vivo.

PubMed

Oei, Gezina T M L; Smit, Kirsten F; vd Vondervoort, Djai; Brevoord, Daniel; Hoogendijk, Arjan; Wieland, Catharina W; Hollmann, Markus W; Preckel, Benedikt; Weber, Nina C

2012-09-24

Helium inhalation protects myocardium, brain and endothelium against ischemia/reperfusion injury in animals and humans, when applied according to specific "conditioning" protocols. Before widespread use of this "conditioning" agent in clinical practice, negative side effects have to be ruled out. We investigated the effect of prolonged helium inhalation on the responsiveness of the human immune response in whole blood ex vivo. Male healthy volunteers inhaled 30 minutes heliox (79%He/21%O(2)) or air in a cross over design, with two weeks between measurements. Blood was withdrawn at T0 (baseline), T1 (25 min inhalation) and T2-T5 (1, 2, 6, 24 h after inhalation) and incubated with lipopolysaccharide (LPS), lipoteichoic acid (LTA), T-cell stimuli anti-CD3/ anti-CD28 (TCS) or RPMI (as control) for 2, 4 and 24 hours or not incubated (0 h). An additional group of six volunteers inhaled 60 minutes of heliox or air, followed by blood incubation with LPS and RPMI. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interferon-γ (IFN-γ) and interleukin-2 (IL-2) was analyzed by cytometric bead array. Statistical analysis was performed by the Wilcoxon test for matched samples. Incubation with LPS, LTA or TCS significantly increased TNF-α, IL-1β, IL-6, IL-8, IFN-γ and IL-2 in comparison to incubation with RPMI alone. Thirty min of helium inhalation did not influence the amounts of TNF-α, IL-1β, IL-6, IL-8, IFN-γ and IL-2 in comparison to air. Sixty min of helium inhalation did not affect cytokine production after LPS stimulation. We conclude that 79% helium inhalation does not affect the responsiveness of the human immune system in healthy volunteers. Dutch Trial Register: http://www.trialregister.nl/ NTR2152.

75 FR 16575 - Open Meeting of the President's Economic Recovery Advisory Board (the PERAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... meeting will be open to the public via live Webcast at http://www.whitehouse.gov/live . DATES: The meeting... will be posted on the White House Web site ( http://www.whitehouse.gov ) without change, including any...:30 p.m. Eastern Time. The meeting will be broadcast on the Internet via live Webcast at http://www...

76 FR 54195 - 2010 Resources Planning Act (RPA) Assessment Draft

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... Resources Planning Act (RPA) Assessment is available for review and comment at http://www.fs.fed.us/research... facsimile to 703-605-5131 or by email using the comment form on the Web site http://www.fs.fed.us/research... . Additional information about the RPA Assessment can be obtained on the Internet at http://www.fs.fed.us...

75 FR 58465 - U.S. Department of State Advisory Committee on Private International Law: Notice of Annual Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... Choice of Court Agreements, the UNCITRAL E-Commerce and Letter of Credit Conventions, and others... Friday. Time permitting, the discussion is expected to focus on developments in a number of areas, e.g...://www.unidroit.org ; http://www.oas.org , and http://www.nccusl.org . We may, by e-mail, supplement...

76 FR 14017 - Call for Comments on the Draft Report of the Adult Immunization Working Group to the National...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... and recommendations could be found on the Web at http://www.hhs.gov/nvpo/nvac/subgroups/adultimmunization . The Web address where the draft report and recommendations can be found is http://www.hhs.gov...) The draft report and recommendations are available on the Web at http://www.hhs.gov/nvpo/nvac...

75 FR 30105 - Solicitation of Applications for Fiscal Year (FY) 2010 Motor Carrier Safety Assistance Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... on the grants.gov Web site ( http://www.grants.gov ). DATES: FMCSA will initially consider funding... register, go to http://www.grants.gov/applicants/get_registered.jsp . The applicant must download the grant... package. This can be done on the Internet at http://www.grants.gov/applicants/apply_for_grants.jsp . The...

76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... inspection at Docket No. PHMSA-2011-0101 at http://www.regulations.gov . DATES: Submit comments by September... following ways: E-Gov Website: http://www.regulations.gov . This Web site allows the public to enter... comments received will be posted without change to http://www.regulations.gov , including any personal...

76 FR 800 - Policy and Procedural Change Regarding the Publication of Notices of Funding Opportunities in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-06

... Web site, http://www.grants.gov , in accordance with the policy directive issued by the Office of... posted at http://www.grants.gov by following the universal resource locator (URL) link included in the synopsis, or by visiting ETA's Web site at http://www.doleta.gov . DATES: Effective Date: January 6, 2011...

78 FR 14776 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

... for Financial Aid Professionals (IFAP) Web site at: www.ifap.ed.gov . Deadline Dates: The following... site at www.cbfisap.ed.gov . 2. The 2012-2013 Fiscal Operations Report The FISAP must be submitted... the eCampus-Based Web site at www.cbfisap.ed.gov . The FISAP signature page must be mailed to: FISAP...

75 FR 31937 - Standards of Performance for New Stationary Sources and Emission Guidelines for Existing Sources...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

...-and-r[email protected] , Attention Docket ID No. EPA-HQ-OAR-2003-0119. Facsimile: Fax your comments to... otherwise protected through http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is... following Web site: http://www.epa.gov/airquality/combustion . Please refer to this Web site to confirm the...

75 FR 32005 - National Emission Standards for Hazardous Air Pollutants for Major Sources: Industrial...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... Web site. E-mail: Comments may be sent by electronic mail (e-mail) to a-and-r[email protected] otherwise protected through http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is... Web site: http://www.epa.gov/airquality/combustion . Please refer to this Web site to confirm the date...

78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... this project can be viewed or printed on the eLibrary link of Commission's Web site at http://www.ferc...) and the instructions on the Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact...

78 FR 78349 - Andrew Peklo III; Notice of Availability of Draft Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... draft EA may also be viewed on the Commission's Web site at http://www.ferc.gov using the ``eLibrary... CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site http://www.ferc.gov/docs... registration, using the eComment system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your...

78 FR 60271 - Hollow Dam Power Company; Ampersand Hollow Dam Hydro, LLC; Notice of Application for Transfer of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

...Library link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket...) and the instructions on the Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact...

76 FR 12958 - Amnor Hydro West Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... http:[sol][sol]www.ferc.gov/docs-filing/efiling.asp. Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http:[sol][sol]www.ferc.gov/docs-filing...Library'' link of Commission's Web site at http:[sol][sol]www.ferc.gov/docs-filing/ elibrary.asp. Enter...

78 FR 22275 - Collection of Information under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... following means: (1) Online: (a) To Coast Guard docket at http:[sol][sol] www.regulations.gov . (b) To OIRA... Federal holidays. You may also find the docket on the Internet at http:[sol][sol] www.regulations.gov . Copies of the ICRs are available through the docket on the Internet at http:[sol][sol] www.regulations...

77 FR 69897 - Comment Request for Information Collection for Occupational Code Assignment, Extension Without...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

....onetcenter.org/ombclearance.html . DATES: Written comments must be submitted to the office listed in the... information in the O*NET Web sites including O*NET OnLine ( http://online.onetcenter.org ), My Next Move ( www.MyNextMove.gov ) and My Next Move for Veterans ( www.MyNextMove.org/vets ) O*NET Code Connector ( www...

77 FR 2119 - WTO Dispute Settlement Proceeding Regarding China-Anti-Dumping and Countervailing Duty Measures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... from the United States. That request may be found at www.wto.org contained in a document designated as... requested consultations with China. That request may be found at www.wto.org contained in a document... of the Appellate Body, will be available on the Web site of the World Trade Organization, www.wto.org...

Êtes-vous prêt pour un code bleu en cabinet?

PubMed Central

Moore, Simon

2015-01-01

Résumé Problème traité Les urgences médicales sont fréquentes dans le cabinet des médecins de famille, mais nombreux sont ceux qui ne sont pas préparés à répondre aux urgences. Une vidéo éducative en ligne traitant des urgences en cabinet pourrait améliorer la réponse des médecins et de leur personnel aux urgences. Un outil comme celui-là n’a jamais été décrit auparavant. Objectif du programme Utiliser les pratiques fondées sur les données probantes pour produire une vidéo éducative expliquant comment se préparer à parer à une urgence dans un cabinet médical, disséminer la vidéo en ligne et évaluer l’attitude des médecins et de leur personnel à l’égard de la vidéo. Description du programme Une vidéo de 6 minutes a été produite en s’appuyant sur une revue de la littérature récente et des politiques des organismes réglementaires canadiens. La vidéo décrit l’équipement d’urgence recommandé, l’amélioration de la réponse à l’urgence et la formation du personnel en cabinet. Les médecins et leur personnel ont été invités à visualiser la vidéo en ligne à www.OfficeEmergencies.ca. L’opinion de l’auditoire sur le format de la vidéo et son contenu a été évaluée par l’entremise d’un sondage (N = 275). Conclusion Les résultats du sondage indiquent que la vidéo était pertinente et bien présentée, et le format en ligne était pratique et satisfaisant. Les participants s’inscriraient à d’autres formations ayant recours à cette technologie et étaient d’accord pour dire que ce programme améliorerait les soins aux patients.

78 FR 53183 - Request for Public Comments Regarding the Interim Environmental Review of the Trans-Pacific...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... Agreement (TPP). The interim environmental review will be available at: http://www.ustr.gov/trade-topics... available at: http://www.ustr.gov/trade-topics/environment/environmental-reviews . The purpose of...

78 FR 48795 - Airworthiness Directives; BRP-Powertrain GmbH & Co KG Rotax Reciprocating Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

..., contact BRP- Powertrain GmbH & Co KG, Welser Strasse 32, A-4623 Gunskirchen, Austria; Internet: http://www..., A-4623 Gunskirchen, Austria; Internet: http://www.FLYROTAX.com . (4) You may view this service...

76 FR 3180 - National Science Board; Sunshine Act Meetings; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

... Board Web site http:[sol][sol]www.nsf.gov/nsb for additional information and schedule updates (time, place, subject matter or status of meeting) may be found at http:[sol][sol]www.nsf.gov/nsb/notices...

78 FR 23933 - Proposed Agency Information Collection Activities: Proposed Collection Renewal; Comment Request...

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2013-04-23

... any of the following methods: http://www.FDIC.gov/regulations/laws/federal/propose.html . Email... collection can be obtained at the FDIC's Web site: http://www.fdic.gov/regulations/laws/federal/notices.html...

77 FR 15933 - Importation of Wooden Handicrafts From China

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-19

..., in the third column, in footnote 2, in the third line `` https://www.ippc.int/index.php?id=13399&tx...://www.ippc.int/index.php?id=13399&tx_publication_pi1 [showUid]=133703&frompage=13399&type=publication...

76 FR 4084 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

...://www.regulations.gov . Follow the instructions for submitting comments. Mail: Rich Malinowski... Web site at http://www.gulfcouncil.org/ . FOR FURTHER INFORMATION CONTACT: Rich Malinowski, 727-824...

Significance of Hemispheric Security for Mexico

DTIC Science & Technology

2003-04-07

WORD COUNT = 7,976 20 21 ENDNOTES 1 Eugenio Anguiano, “America Latina, en marcha hacia una nueva crisis,” El Universal, 20 Noviembre 2002 [newspaper...Preservacion de la Paz en el Ambito Hemisferico y el Proceso en Torno al Nuevo Concepto de la Seguridad. Organizacion de los Estados Americanos, 56o...Contra el Terrorismo los Avances Democráticos?” Washingtonpost.com, 27 Nov 2002; available from http://www.washingtonpost.com/ac2/wp- dyn/A46924-2002Nov27

78 FR 25320 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

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2013-04-30

... handouts, will be available at http://www.nrc.gov/reading-rm/doc-collections/acmui/meetings/2013.html . The... summary will be available at ( http://www.nrc.gov/reading-rm/doc-collections/acmui/meetings/2013.html...

76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-01

... parts of the National Board Inspection Code at http://www.nationalboard.org . DATES: The comment period... edition of the National Board Inspection Code for public review at www.nationalboard.org . Both documents...

78 FR 27279 - WTO Dispute Settlement Proceeding Regarding Indonesia-Importation of Horticultural Products...

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2013-05-09

....wto.org contained in a document designated as WT/DS455/7. USTR invites written comments from the... the World Trade Organization, at www.wto.org . Comments open to public inspection may be viewed at www...

76 FR 52045 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping Measures on Diamond...

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2011-08-19

... regarding diamond sawblades and parts thereof from China. That request may be found at http://www.wto.org... of the World Trade Organization, http://www.wto.org . Comments open to public inspection may be...

Fuel Injection Strategy for a Next Generation Pulse Detonation Engine

DTIC Science & Technology

2006-06-01

at 45°C CE Approved EMC EMC Directive 89/336/EEC; EN 61326-1 Emissions and Immunity Safety Low Voltage Directive 73/23/EEC; EN 61010 -1...Operating Humidity 0–90% Nonoperating Humidity 0–100% CDRH Class IIIb IEC Class 3B From www.mellesgriot.com 47 SILICON OPTICAL SENSOR Model

78 FR 26171 - Magnuson-Stevens Fishery Conservation and Management Act Provisions; Fisheries of the...

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2013-05-03

... be found at: http://www2.mar.dfo-mpo.gc.ca/science/trac/tsr.html . The 2012 TRAC noted that, in... the 2012 TRAC assessment can be found at: http://www2.mar.dfo-mpo.gc.ca/science/trac/tsr.html . The... available from the Northeast Fisheries Science Center (NEFSC) at: http://www.nefsc.noaa.gov/saw/saw55...

76 FR 6811 - Notice of Availability: Notice of Technical Correction to the Notice of Public Interest (NOPI...

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2011-02-08

..., 2011, HUD posted on http://www.Grants.gov , a Notice of Public Interest (NOPI) for Fiscal Year 2010... posted to http://www.Grants.gov a technical correction to that notice. The technical correction adds an... Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to...

78 FR 934 - 37 Wilton Road, Milford LLC, and 282 Route 101 LLC, PVM Commercial Center, LLC; Notice of...

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2013-01-07

... printed on the eLibrary link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp... Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp . Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http://www.ferc...

77 FR 21761 - Alice Falls Corporation, Alice Falls Hydro, LLC; Notice of Application for Transfer of License...

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2012-04-11

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76 FR 72699 - KC Hydro LLC of New Hampshire; Notice of Preliminary Permit Application Accepted for Filing and...

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2011-11-25

....2001(a)(1)(iii) and the instructions on the Commission's Web site http:[sol][sol]www.ferc.gov/docs... registration, using the eComment system at http:[sol][sol]www.ferc.gov/docs-filing/ecomment.asp. You must... http:[sol][sol]www.ferc.gov/docs-filing/ elibrary.asp. Enter the docket number (P-14248-000) in the...

76 FR 10054 - Notice of Availability: Notice of Technical Correction to the Notice of Funding Availability for...

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2011-02-23

...: Notice. SUMMARY: On January 20, 2011, HUD posted on http://www.Grants.gov , a Notice of Funding... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm...

75 FR 23318 - WTO Dispute Settlement Proceeding Regarding Philippines-Taxes on Distilled Spirits

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2010-05-03

... request may be found at http://www.wto.org in a document designated as WT/DS403/4. The panel was...://www.wto.org contained in a document designated as WT/DS403/1. Consultations were held in Geneva on... available on the Web site of the World Trade Organization, http://www.wto.org . Comments will be placed in...

A Communications Strategy for Disaster Relief

DTIC Science & Technology

2015-03-01

there were “ pockets ” of cellular coverage in the immediate aftermath of the earthquake, thus enabling some critical life-saving SMS traffic.105 4...Accessed 30 October 2014. http://www.oxfam.org/en/haiti-earthquake-our-response. Oxford Learners Dictionary . “Definition of Wicked.” Oxford University...Press. Assessed 02 September 2014. http://www.oxfordlearnersdictionaries.com/ definition/ english /wicked_1. Pacific Disaster Center. “Disaster Response

Differential effects of selective cyclooxygenase (COX)-1 and COX-2 inhibitors on anorexic response and prostaglandin generation in various tissues induced by zymosan.

PubMed

Naoi, Kazuhisa; Kogure, Suguru; Saito, Masataka; Hamazaki, Tomohito; Watanabe, Shiro

2006-07-01

We have shown that anorexic response is induced by intraperitoneal injection of zymosan in mice, although the role of prostaglandins in this response is relatively unknown as compared with lipopolysaccharide (LPS)-induced anorexic response. Indomethacin (0.5 and 2.0 mg/kg), a non-selective cyclooxygenase (COX) inhibitor, as well as meloxicam (0.5 mg/kg), a selective COX-2 inhibitor, but not FR122047 (2.0 mg/kg), a selective COX-1 inhibitor, attenuated zymosan-induced anorexia. Zymosan injection elevated COX-2 expression in brain and liver but not in small intestine and colon. Meloxicam (0.5 mg/kg) and FR122047 treatment (2.0 mg/kg) similarly suppressed the generation of brain prostaglandin E(2) (PGE(2)) and peritoneal prostacyclin (PGI(2)) upon zymosan injection. PGE(2) generation in liver upon zymosan injection was suppressed by meloxicam (0.5 mg/kg) but not by FR122047 treatment (2.0 mg/kg). Our observations suggest that COX-2 plays an important role in zymosan-induced anorexia, which is a similar feature in LPS-induced anorexic response. However, non-selective inhibition by selective COX-1 and COX-2 inhibitors of brain PGE(2) generation upon zymosan injection does not support the role of COX-2 expressed in brain in zymosan-induced anorexic response. PGE(2) generation in liver may account for peripheral role of COX-2 in zymosan-induced anorexic response.

75 FR 78231 - Management of Energy and Water Efficiency in Federal Buildings: Availability of Guidance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

... Buildings) is available at: http://www1.eere.energy.gov/femp/pdfs/draft_EISA_project_guidance.pdf DATES... at: http://www1.eere.energy.gov/femp/pdfs/draft_EISA_project_guidance.pdf . DOE will accept comments...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

77 FR 73386 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; the 2002 Base Year...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... Department of the Environment (MDE), on June 6, 2008 for Baltimore, Maryland. In the Final Rules section of... www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system...

75 FR 22256 - Difenoconazole Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... http://www.gpoaccess.gov/ecfr . To access the OPPTS Harmonized Test Guidelines referenced in this document electronically, please go to http://www.epa.gov/oppts and select ``Test Methods & Guidelines'' on... food as follows: i. Acute exposure. Quantitative acute dietary exposure and risk assessments are...

76 FR 12401 - WTO Dispute Settlement Proceeding Regarding China-Certain Measures Affecting Electronic Payment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

...://www.wto.org contained in a document designated as WT/DS413/2. USTR invites written comments from the... available on the Web site of the World Trade Organization, http://www.wto.org . Comments open to public...

78 FR 12414 - WTO Dispute Settlement Proceeding Regarding United States-Measures Affecting the Importation of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

....org contained in a document designated as WT/DS447/2. USTR invites written comments from the public... the World Trade Organization, at www.wto.org . Comments open to public inspection may be viewed at www...

75 FR 60159 - WTO Dispute Settlement Proceeding Regarding China-Certain Measures Affecting Electronic Payment...

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2010-09-29

... found at www.wto.org contained in a document designated as WT/DS413/1. USTR invites written comments... Appellate Body, will be available on the web site of the World Trade Organization, http://www.wto.org...

77 FR 44706 - WTO Dispute Settlement Proceeding Regarding China-Measures Related to the Exportation of Rare...

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2012-07-30

... Establishing the World Trade Organization (``WTO Agreement''). That request may be found at www.wto.org... available on the Web site of the World Trade Organization, www.wto.org . Comments open to public inspection...

76 FR 17985 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping Measures on Certain Frozen...

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2011-03-31

....org contained in a document designated as WT/DS422/1. USTR invites written comments from the public... Organization, http://www.wto.org . Comments open to public inspection may be viewed on the http://www...

76 FR 11553 - WTO Dispute Settlement Proceeding Regarding United States-Anti Dumping Measures on Corrosion...

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2011-03-02

... http://www.wto.org contained in a document designated as WT/ DS420/1. USTR invites written comments... World Trade Organization, http://www.wto.org . Comments open to public inspection may be viewed on the...

The Uruguayan Armed Forces and the Challenge of 21st Century Peacekeeping Operations

DTIC Science & Technology

2005-12-01

Ejército, de la Armada Nacional y de la Fuerza Aérea Uruguaya para participar en el mantenimiento de la paz en el Congo. En consideración. Aprobado...el Mantenimiento de Paz por las Naciones Unidas,” Air Power Journal, Ediciόn Hispanoamericana (Primavera 1996): 11, http...www.mercosur.org.uy/pagina1esp.htm. 82 SINOMAPA stands for “Sistema Nacional de Apoyo a las Operaciones de Mantenimiento de la Paz.” 83 Poder Ejecutivo de la

Deflecting Hurakan: Enhancing DOD and DOS Interagency Hurricane Response Operations in Central America

DTIC Science & Technology

2010-04-01

INformation ―Coordinacion logistica y vías de acceso en la RAAN - Informacion actualizada‖, 15 Sep 2007; http://www.logcluster.org/ops/hurricane-felix...coordination/coordinacion- logistica -y- vias- de -acceso-en-la-raan-informacion-actualizada. 80 MC1 Michael Wimbish, ―U.S. Military Forces Wrap up Hurricane...Dept04.htm (accessed 02 March 2010). Puente Aéreo (Air Bridge) Information ―Coordinacion logistica y vías de acceso en la RAAN – Informacion

20 CFR 703.2 - Forms.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Insurance Carrier's Agreement and Undertaking. (5) LS-276 Application for Security Deposit Determination. (6... Internet at http://www.dol.gov/owcp/dlhwc. [70 FR 43233, July 26, 2005, as amended at 77 FR 37286, June 21...

20 CFR 703.2 - Forms.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Insurance Carrier's Agreement and Undertaking. (5) LS-276 Application for Security Deposit Determination. (6... Internet at http://www.dol.gov/owcp/dlhwc. [70 FR 43233, July 26, 2005, as amended at 77 FR 37286, June 21...

75 FR 70921 - Simon Property Group, Inc.; Analysis of Proposed Agreement Containing Consent Orders To Aid...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... site, at http:[sol][sol]www.ftc.gov[sol]os[sol]publiccomments.shtm. Because comments will be made.../simonproperty . If this Notice appears at http:[sol][sol]www.regulations.gov[sol]search[sol]index.jsp, you may... regulations.gov forwards to it. You may also visit the FTC Web site at http:[sol][sol]www.ftc.gov[sol] to read...

75 FR 62624 - WTO Dispute Settlement Proceeding Regarding United States-Final Antidumping Measures on Stainless...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... request may be found at http://www.wto.org in document WT/DS344/20. USTR invites written comments from the... in that dispute, which can be found at http://www.wto.org in documents WT/DS344/R and WT/DS344/AB/R...://www.wto.org . Comments will be placed in the docket and open to public inspection pursuant to 15 CFR...

Chado controller: advanced annotation management with a community annotation system.

PubMed

Guignon, Valentin; Droc, Gaëtan; Alaux, Michael; Baurens, Franc-Christophe; Garsmeur, Olivier; Poiron, Claire; Carver, Tim; Rouard, Mathieu; Bocs, Stéphanie

2012-04-01

We developed a controller that is compliant with the Chado database schema, GBrowse and genome annotation-editing tools such as Artemis and Apollo. It enables the management of public and private data, monitors manual annotation (with controlled vocabularies, structural and functional annotation controls) and stores versions of annotation for all modified features. The Chado controller uses PostgreSQL and Perl. The Chado Controller package is available for download at http://www.gnpannot.org/content/chado-controller and runs on any Unix-like operating system, and documentation is available at http://www.gnpannot.org/content/chado-controller-doc The system can be tested using the GNPAnnot Sandbox at http://www.gnpannot.org/content/gnpannot-sandbox-form valentin.guignon@cirad.fr; stephanie.sidibe-bocs@cirad.fr Supplementary data are available at Bioinformatics online.

78 FR 5838 - NRC Enforcement Policy

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... submit comments by any of the following methods: Federal Rulemaking Web site: Go to http://www... of the following methods: Federal Rulemaking Web site: Go to http://www.regulations.gov and search... the search, select ``ADAMS Public Documents'' and then select ``Begin Web-based ADAMS Search.'' For...

77 FR 11555 - Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors: Institutional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... either http://www.regulations.gov or http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinical...] Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors: Institutional Review Board Continuing Review After Clinical Investigation Approval; Availability AGENCY: Food and Drug Administration...

77 FR 47084 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... of http:// August 6, 2012....... 210067 Fayette Urban Gray, Mayor, Planning, Current www.bakeraecom... Oxnard (12- The Honorable Planning http:// August 6, 2012....... 060417 09-1132P) Thomas E. Holden... Department of http:// July 13, 2012........ 080087 areas of Jefferson Donald Rosier, Planning and www...

75 FR 14442 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

..., Appendices A through D. The tables are instead published at http://www.gsa.gov/relocationpolicy . FTR Bulletin 10-04 is attached. FTR Bulletin 10-04 and all other FTR Bulletins may be found at http://www.gsa...

75 FR 12167 - Virginia Graeme Baker Pool and Spa Safety Act; Public Accommodation

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2010-03-15

... following methods: Electronic Submissions Submit electronic comments in the following way: Federal e... mail (e-mail) except through http://www.regulations.gov . Written Submissions Submit written... http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: Barbara E. Little, Regulatory Affairs...

76 FR 14572 - Federal Acquisition Regulation; Technical Amendments

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2011-03-16

... Acquisition Regulations. List of Subjects in 48 CFR Parts 18, 19, and 52 Government procurement. Dated: March... in paragraph (b) by removing ``http:// www.whitehouse.gov/omb/procurement/guides/emergency_acquisitions_ guide.pdf'' and adding ``http://www.whitehouse.gov/sites/default/files/ omb/assets/procurement...

75 FR 51458 - Notice of Extended Availability of Draft National Pollutant Discharge Elimination System (NPDES...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... No. EPA-R01-OW-2010- 0292 by one of the following methods: http://www.regulations.gov : Follow the on..., appendices, and fact sheet are available at: http://www.epa.gov/region1/npdes/stormwater . DATES: The public...

41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

Code of Federal Regulations, 2012 CFR

2012-07-01

... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

Code of Federal Regulations, 2011 CFR

2011-07-01

... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

Code of Federal Regulations, 2013 CFR

2013-07-01

... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

Code of Federal Regulations, 2014 CFR

2014-07-01

... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

77 FR 60660 - Proposed Establishment Class E Airspace; Kasigluk, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... your comments. You may also submit comments through the Internet at http://www.regulations.gov . FOR..., aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications should...). You may also submit comments through the Internet at http://www.regulations.gov . Commenters wishing...

77 FR 74737 - Petition for Waiver of Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... any written communications concerning the petition, is available for review online at www.regulations..., before the end of the comment period and specify the basis for their request. All communications... following methods: Web site: http://www.regulations.gov . Follow the online instructions for submitting...

77 FR 18296 - WTO Dispute Settlement Proceeding Regarding India-Measures Concerning the Importation of Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... because of concerns related to Avian Influenza. That request may be found at www.wto.org contained in a... available on the Web site of the World Trade Organization, www.wto.org . Comments open to public inspection...

75 FR 60161 - WTO Dispute Settlement Proceeding Regarding China-Countervailing and Antidumping Duties on Grain...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

... States of grain oriented flat-rolled electrical steel. That request may be found at http://www.wto.org...://www.wto.org . Comments will be placed in the docket and open to public inspection pursuant to 15 CFR...

78 FR 16754 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping Measures on Certain Shrimp...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

....wto.org contained in a document designated as WT/DS429/3. USTR invites written comments from the... the World Trade Organization, at www.wto.org . Comments open to public inspection may be viewed at www...

77 FR 37730 - WTO Dispute Settlement Proceeding Regarding United States-Countervailing Duty Measures on Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... for consultations may be found at www.wto.org contained in a document designated as WT/DS437/1. USTR..., will be available on the Web site of the World Trade Organization, www.wto.org . Comments open to...

77 FR 53959 - WTO Dispute Settlement Proceeding Regarding Argentina-Measures Affecting the Importation of Goods

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... by Argentina on the importation of goods. That request may be found at www.wto.org , contained in a... Appellate Body, will also be available on the Web site of the World Trade Organization at www.wto.org...

78 FR 79427 - Greenwood County; Notice of Application Accepted for Filing and Soliciting Comments, Motions To...

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2013-12-30

... Commission's Web site at http://www.ferc.gov/docs-filing/efiling.asp . Commenters can submit brief comments... calling (202) 502-8371. This filing may also be viewed on the Commission's Web site at http://www.ferc.gov...

77 FR 23513 - Sunshine Act Meeting; Agenda

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2012-04-19

... Maintenance-of-Way Equipment Train, Red Oak, Iowa, April 17, 2011 (DCA-11-FR-002) NEWS MEDIA CONTACT... archived webcast by accessing a link under ``News & Events'' on the NTSB home page at www.ntsb.gov...

Atelier d'astronomie X

NASA Astrophysics Data System (ADS)

Ballet, J.; Barret, D.

2001-01-01

L'astronomie X connait aujourd'hui une de ses périodes les plus actives et les plus fastes, après le lancement de Chandra et XMM-Newton, et alors que Beppo SAX et Rossi XTE sont toujours en orbite. L'extraordinaire complémentarité de ces satellites est telle que leur domaine d'utilisation est extrêmement vaste, couvrant des étoiles jeunes aux toujours énigmatiques sursauts γ, en passant bien entendu par les trous noirs accrétants dans les binaires X ou dans les noyaux actifs de galaxies. L'atelier fut organisé selon quatre thèmes les étoiles, les phénomènes explosifs, les binaires X et les noyaux actifs de galaxies. Les résultats qui y furent présentés, pour chacun de ces thèmes témoignent de la superbe qualité des données obtenues. En particulier l'accès à la haute résolution spectrale (réseaux) en rayons X marque un pas important. Les présentations plus théoriques ont montré que parallèlement des progrès significatifs sont réalisés dans la physique de l'accrétion autour des objets compacts. Les actes de l'atelier donnent un panorama représentatif des progrès réalisés récemment par l'astronomie X, aussi bien du point de vue observationnel que théorique. Ces actes de colloque sont aussi l'occasion de rappeler l'historique et ce que furent les activités scientifiques de notre GdR au moment ou il doit s'intègrer au GdR PCHE et au PNPS. Enfin, pour toutes informations complémentaires concernant l'atelier: http://www.cesr.fr/~barret/adj/vg.html Ce site donne accès en particulier à la plupart des présentations (transparents).

76 FR 48919 - NRC Enforcement Policy

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... Web site and on the Federal rulemaking Web site, http://www.regulations.gov . Because your comments... publicly disclosed. You may submit comments by any one of the following methods: Federal Rulemaking Web... Web site: Public comments and supporting materials related to this notice can be found at http://www...

78 FR 59866 - New Car Assessment Program (NCAP)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... because ESC is now required for all light vehicles. For many years, NCAP has provided comparative... site, www.safercar.gov . NCAP provides comparative information on the safety performance and features... Features on www.safercar.gov are designed to assist drivers in avoiding backover crashes. After considering...

78 FR 40027 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... chromatography/ultraviolet (HPLC/UV) method) are available to enforce the tolerance expression. The method may be... available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER...

77 FR 75039 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

...- 671A) is available to enforce the tolerance expression. The method may be requested from: Chief... action, identified by docket identification (ID) number EPA-HQ-OPP-2011-0772, is available at http://www... additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER INFORMATION...

76 FR 27261 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... identified and discussed later in this document. Interregional Research Project 4 (IR-4) requested these... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and...

76 FR 16795 - The National Antimicrobial Resistance Monitoring System Strategic Plan 2011-2015; Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

....fda.gov/AnimalVeterinary/SafetyHealth/AntimicrobialResistance/NationalAntimicrobialResistanceMonitoringSystem/default.htm , http://www.fda.gov/AnimalVeterinary/SafetyHealth/AntimicrobialResistance/NationalAntimicrobialResistanceMonitoringSystem/ucm062630.htm , http://www.fda.gov/AnimalVeterinary/Safety...

76 FR 6123 - Reducing Regulatory Burden

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... any of the following methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the... read background documents, or comments received, go to the Federal eRulemaking Portal at http://www... consequences of a rule, including its costs and benefits, until it has been tested. Because knowledge about the...

76 FR 15224 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... Department's Regulations Portal at http://www.dol.gov/regulations/regreview.htm . All comments will be.... The Department recognizes the knowledge of programs and their implementing regulations that exists... portal specifically designed to capture your input and suggestions, http://www.dol.gov/regulations...

78 FR 16202 - Proposed Amendment of Class E Airspace; Selmer, TN

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

.... You may also submit and review received comments through the Internet at http://www.regulations.gov..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

76 FR 66871 - Proposed Establishment of Class E Airspace; Inverness, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... your comments. You may also submit and review received comments through the Internet at http://www..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

76 FR 58727 - Proposed Amendment of Class E Airspace; Cumberland, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-22

... comments. You may also submit and review received comments through the Internet at http://www.regulations..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Comments wishing the FAA to...

78 FR 26557 - Proposed Amendment of Class E Airspace; Plattsburgh, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

... and review received comments through the Internet at http://www.regulations.gov . FOR FURTHER..., environmental, and energy-related aspects of the proposal. Communications should identify both docket numbers... comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to acknowledge...

78 FR 58490 - Proposed Establishment of Class E Airspace; Donlin Creek, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... comments through the Internet at http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT: Richard..., environmental, and energy-related aspects of the proposal. Communications should identify both docket numbers... comments through the Internet at http://www.regulations.gov . Commenters wishing the FAA to acknowledge...

77 FR 55776 - Proposed Establishment of Class E Airspace; Walsenburg, CO

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

75 FR 42630 - Proposed Establishment of Class E Airspace; Lancaster, NH

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... received comments through the Internet at http://www.regulations.gov . FOR FURTHER INFORMATION CONTACT..., environmental, and energy-related aspects of the proposal. Communications should identify both docket numbers... comments through the Internet at http://www.regulations.gov . Commenters wishing the FAA to acknowledge...

75 FR 54057 - Proposed Modification of Class E Airspace; Portland, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

77 FR 27149 - Proposed Modification of Class E Airspace; Unalakleet, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

77 FR 61304 - Proposed Amendment of Class E Airspace; Savoonga, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

76 FR 66867 - Proposed Amendment of Class E Airspace; Rockingham, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... your comments. You may also submit and review received comments through the Internet at http://www..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

78 FR 73465 - Proposed Amendment of Class E Airspace; Morrisville, VT

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... also submit and review received comments through the Internet at http://www.regulations.gov . FOR..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

77 FR 27148 - Proposed Establishment of Class E Airspace; Roundup, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

78 FR 31871 - Proposed Amendment of Class E Airspace; Gustavus, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... your comments. You may also submit comments through the Internet at http://www.regulations.gov . FOR..., aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications should... and phone number). You may also submit comments through the Internet at http://www.regulations.gov...

77 FR 46788 - WTO Dispute Settlement Proceeding Regarding China-Anti-Dumping and Countervailing Duties on...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... request may be found at www.wto.org , contained in a document designated as WT/DS440/1. USTR invites... Appellate Body, will also be available on the Web site of the World Trade Organization at www.wto.org...

75 FR 50033 - WTO Dispute Settlement Proceeding Regarding United States-Measures Affecting the Production and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... (Pub. L. 111-31). That request may be found at http://www.wto.org in a document designated as WT/DS406... Organization, http://www.wto.org . Comments will be placed in the docket and open to public inspection pursuant...

78 FR 58378 - WTO Dispute Settlement Proceeding Regarding Anti-Dumping and Countervailing Measures on Large...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

... request may be found at www.wto.org in a document designated as WT/DS464/1. USTR invites written comments... available on the Web site of the World Trade Organization, at www.wto.org . Comments open to public...

77 FR 25184 - Oncologic Drugs Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

... disability, visitor parking, and transportation may be accessed at: http://www.fda.gov/AdvisoryCommittees... at http://www.fda.gov/AdvisoryCommittees/default.htm to learn about possible modifications before... effort to accommodate persons with physical disabilities or special needs. If you require special...

76 FR 6110 - Mine Safety Disclosure

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/proposed.shtml ); Send an e... all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/proposed.shtml... on the proposal to, among other things, allow for the collection of information and improve the...

77 FR 58991 - State-Level Guarantee Fee Pricing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-25

.../relatedservicinginfo/pdf/foreclosuretimeframes.pdf and http://www.freddiemac.com/learn/pdfs/service/exhibit83.pdf . The... Relative to the National Average Estimated Cost per day Foreclosure average Total time to relative to Rank.../guides/ssg/relatedservicinginfo/pdf/foreclosuretimeframes.pdf and http://www.freddiemac.com/learn/pdfs...

76 FR 39315 - Preliminary Plan for Retrospective Analysis of Existing Rules; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-06

...Rulemaking Portal: http://www.regulations.gov . Follow the instructions for submitting comments. Electronic...Rulemaking Portal at http://www.regulations.gov . Electronic submission of comments allows the commenter... for General Law, Ethics, and Regulation at [email protected] . SUPPLEMENTARY INFORMATION: On...

Effects of Coriolus versicolor polysaccharide B on monocyte chemoattractant protein 1 gene expression in rat.

PubMed

Song, Lie-Chang; Chen, Hai-Sheng; Lou, Ning; Song, Chang; Zeng, Jun; Fu, Ting-Huan

2002-06-01

To investigate the effect of Coriolus versicolor polysaccharide B (CVPS-B), a new water-soluble component of polysaccharides from the fungus Coriolus versicolor (Fr) L on monocyte chemoattractant protein-1 (MCP-1) gene expression in rat splenocytes. Expression of MCP-1 mRNA in rat splenocytes was examined by reverse transcription-polymerase chain reaction (RT-PCR) with beta- actin as an internal standard. Sequencing of RT-PCR products was performed to confirm their specificity in MCP-1 gene composition. (1) Without pre-treatment of lipopolysaccharide (LPS), the relative MCP-1 mRNA expression ratios (MCP-1/beta-actin) for the saline control group and for CVPS-B groups in 3 different doses (10, 20, and 30 mg . kg-1 . d-1, ip, for 4 d) were 1.4 +/- 0.3, 1.6 +/- 0.4, 1.7 +/- 0.5, and 1.5 +/- 0.4, respectively (P > 0.05); (2) LPS (10 microg . kg-1, ip) enhanced the expression of MPC-1 mRNA by the ratio of 114 %; (3) pre-treatment with CVPS-B of 4 different doses (5, 10, 30, and 50 mg . kg-1 . d-1, ip, for 4 d) decreased the LPS induced expression of MPC-1 mRNA by the ratios of 51 %, 70 %, 84 %, and 99 %, respectively (n = 6). In a dose-related fashion, CVPS-B inhibited the expression of MCP-1 mRNA induced by LPS in the rat splenocytes, but did not significantly affect the expression of MPC-1 mRNA in the normal rat.

Surgical anatomy and histology of the levator palpebrae superioris muscle for blepharoptosis correction.

PubMed

Djordjević, Boban; Novaković, Marijan; Milisavljević, Milan; Milićević, Sasa; Maliković, Aleksandar

2013-12-01

The detailed knowledge of the architecture of the upper eyelid is very important in numerous upper eyelid corrective surgeries. The article deals with the detailed anatomy of the major components of the upper lid, which are commonly seen in surgical practice. This study was conducted on 19 human cadavers (12 adults and 7 infants) without pathologic changes in the orbital region and eyelids. Anatomic microdissection of the contents of the orbita was performed bilaterally on 12 orbits from 6 unfixed cadavers (3 male and 3 female). Micromorphologic investigations of the orbital tissue were performed on 8 en bloc excised and formalin-fixed orbits of infant cadavers. Specimens were fixed according to the Duvernoy method. An intra-arterial injection of 5% mixture of melt formalin and black ink was administered into the carotid arterial system. Using routine fixation, decalcination, dehydration, illumination, impregnation and molding procedures in paraplast, specimens were prepared for cross-sections. The measurement of the muscle length and diameter in situ in 6 nonfixed cadavers (12 orbits) showed an average length of the levator palpbrae superioris (LPS) muscle body of the 42.0 +/- 1.41 mm on the right, and 40.3 +/- 1.63 mm on the left side. In all the cases, the LPS had blood supply from 4 different arterial systems: the lacrimal, supratrochlear, and supraorbital artery and muscle branches of the ophthalmic artery. The LPS muscle in all the specimens was supplied by the superior medial branch of the oculomotor nerve. The connective tissue associated with the LPS muscle contains two transverse ligaments: the superior (Whitnall's) and intermuscular transverse ligaments (ITL). The orbital septum in all the specimens originated from the arcus marginalis of the frontal bone, and consisted of two layers--the superficial and the inner layer. In addition, a detailed histological analysis revealed that the upper eyelid's crease was formed by the conjoined fascia including the fascia of the orbicularis muscle, the superficial layer of the orbital septum, and the aponeurosis of the LPS muscle, as well as the pretarsal fascia. The conducted study provided a valuable morphological basis for biomechanical and clinical considerations regarding blepharoptosis surgery.

Cholera

MedlinePlus

... from cholera. WHO 2016. www.who.int/cholera/technical/en/ . Accessed March 18, 2016. Review Date 3/ ... Duplication for commercial use must be authorized in writing by ADAM Health Solutions. About MedlinePlus Site Map ...

76 FR 35433 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... Oil and Gas Management Plan, Implementation, KY and TN, Comment Period Ends: 08/15/ 2011, Contact: Dan... available on the Internet at: http://www.udot.utah.gov/bangerter600west/documents.html . Revision to FR...

77 FR 41774 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-16

... records is deleted: (18-05-14) Human Capital Learning and Performance Improvement System, 69 FR 19171... Department published in the Federal Register by using the article search feature at: www.federalregister.gov... name 18-05-14 Human Capital Learning and Performance Improvement System. [FR Doc. 2012-17310 Filed 7-13...

76 FR 65756 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... 600.400, Administrative Litigation Records; USPS 810.100, http://www.usps.com Registration; USPS 810... Records; USPS 870.200, Postage Meter and PC Postage Customer Data and Transaction Records; USPS 880.000....400 SYSTEM NAME: Administrative Litigation Records USPS 810.100 SYSTEM NAME: http://www.usps.com...

76 FR 6181 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

....regulations.gov/search/index.jsp . Specifically address whether this information collection is necessary for... version of this document is available on the World Wide Web at http://www.regulations.gov/search/index.jsp... visit http://www.regulations.gov/search/index.jsp . By Order of the Maritime Administrator. Dated...

77 FR 64244 - Revision to Ambient Nitrogen Dioxide Monitoring Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-19

...- OAR-2012-0486 by one of the following methods: www.regulations.gov : Follow the online instructions... public docket without change and may be made available online at http://www.regulations.gov , including... and made available on the Internet. If you submit an electronic comment, the EPA recommends that you...

77 FR 60452 - National Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... will be posted to the NAC Web site, as they become available. Contact the Office of the National..., and email [email protected] . The National Advisory Council Web site is located at: http://www... preparing for, responding to, and recovering from disasters. More information can be found at http://www...

77 FR 69923 - Petition for Waiver of Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... businesses, while maintaining the safety of an audible warning by ringing the bell. A copy of the petition, as well as any written communications concerning the petition, is available for review online at www... following methods: Web site: http://www.regulations.gov/ . Follow the online instructions for submitting...

75 FR 9451 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

..., 301-415-6749.) This meeting will be webcast live at the Web address-- http://www.nrc.gov , Week of... Commission and the Nuclear Regulatory Commission on Grid Reliability (Public Meeting). (Contact: Kenn Miller, 301-415-3152.) This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week of...

75 FR 12583 - Sunshine Act; Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

... Commission and the Nuclear Regulatory Commission on Grid Reliability (Public Meeting). (Contact: Kenn Miller, 301-415-3152). This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week of...) (Contact: Jose Ibarra, 301-415-2581). This meeting will be webcast live at the Web address-- http://www.nrc...

75 FR 45485 - Determination of Attainment for PM10

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-03

... reports for years 2007, 2008, and 2009. Furthermore, we concluded in our Technical System Audit Report...://www.regulations.gov or e-mail. http://www.regulations.gov is an ``anonymous access'' system, and EPA... System (AQS) database. Data from air monitors operated by State/local/tribal agencies in compliance with...

76 FR 6475 - Emergency Responder Health Monitoring and Surveillance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... document and instructions for submitting comments can be found at: http://www.cdc.gov/niosh/docket/review... an emergency response are utilized to mitigate adverse physical and psychological outcomes and...: http://www.cdc.gov/niosh/docket/review/docket223/ . This guidance does not have the force and effect of...

78 FR 46256 - Adoption of Updated EDGAR Filer Manual

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2013-07-31

... (202) 551-3600; in the Division of Trading and Markets for questions concerning Form 13H contact...://www.sec.gov/info/edgar.shtml . You can also inspect the document at the National Archives and Records...: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html . By the...

76 FR 55377 - Public Utility District No. 1 of Okanogan County, WA, Notice of Availability of Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-07

... Commission in the Public Reference Room or may be viewed on the Commission's Web site at http:[sol][sol]www... http:[sol][sol]www.ferc.gov/docs- filing/esubscription.asp to be notified via e-mail of new filings and...

75 FR 62024 - Metal and Nonmetal Dams

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... the following methods: (1) Federal Rulemaking Portal: http:[sol][sol]www.regulations.gov. Follow the... receptionist's desk on the 21st floor. (6) Docket: Comments can be accessed electronically at http:[sol][sol... publishes rulemaking documents in the Federal Register. To subscribe, go to http:[sol][sol]www.msha.gov...

78 FR 48639 - North Dakota Underground Injection Control Program Revision Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... Dakota Industrial Commission, Oil and Gas Division 1016 East Calgary Avenue, Bismarck, North Dakota 58503... the North Dakota Industrial Commission (NDIC) to issue UIC permits for carbon geo-sequestration... protected through www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access...

75 FR 81878 - Imazosulfuron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go http://www.epa.gov/ocspp and select ``Test Methods and... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

75 FR 69353 - Isoxaben; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

78 FR 19130 - Clothianidin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

... one of the following methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the..., which is available in the docket, http://www.regulations.gov . One comment was received on the notice of... validity, completeness, and reliability as well as the relationship of the results of the studies to human...

78 FR 18928 - Proposed Amendment of Class E Airspace; Tuskegee, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

.... You may also submit and review received comments through the Internet at http://www.regulations.gov..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... also submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

78 FR 5754 - Proposed Amendment of Class D and Class E Airspace; Reading, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... also submit and review received comments through the Internet at http://www.regulations.gov . FOR..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Persons wishing the FAA to...

75 FR 34449 - Agency Information Collection Activities: Extension Without Change of Existing Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

... to EEOC, comments may be submitted to EEOC electronically on the Federal eRulemaking Portal: http://www.regulations.gov . After accessing this web site, follow its instructions for submitting comments. All comments received will be posted without change to http://www.regulations.gov , including any...

77 FR 47117 - Chemical, Biological, Radiological, Nuclear (CBRN) Protective Ensemble Standard, Certification...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... (at www.justnet.org ) three draft documents related to Chemical, Biological, Radiological, Nuclear... until September 21, 2012. FOR FURTHER INFORMATION CONTACT: For further information, see www.justnet.org , or contact David Otterson by telephone at 301-519-5498 or by email at [email protected]org...

75 FR 20670 - WTO Dispute Settlement Proceeding Regarding United States-Use of Zeroing in Anti-Dumping Measures...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

.... That request may be found at http://www.wto.org in a document designated as WT/DS402/3. USTR invites... of the World Trade Organization, http://www.wto.org . Comments will be placed in the docket and open...

76 FR 43691 - Unique Device Identification for Postmarket Surveillance and Enforcement; Public Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... Internet access, please contact Jay Crowley (see Contact Person) to register. Registration requests should... lodging, and other relevant information on the Internet at http://www.fda.gov/UDI . Comments: Regardless... Sentinel Initiative, on the Internet at http://www.fda.gov/Safety/FDAsSentinelInitiative/default.htm...

76 FR 6110 - Conflict Minerals

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

...'s Internet comment form ( http://www.sec.gov/rules/proposed.shtml ); Send an e-mail to rule-comments... on the Commission's Internet Web site ( http://www.sec.gov/rules/proposed.shtml ). Comments are also... report, and make its reports available to the public on its Internet Web site. The release was published...

76 FR 43960 - NARA Records Reproduction Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... transferred to NARA and maintain its fee schedule on NARA's Web site http://www.archives.gov . The proposed... document is faint or too dark, it requires additional time to obtain a readable image. In TABLE 1 below... our Web site ( http://www.archives.gov ) annually when announcing that records reproduction fees will...

77 FR 74859 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-18

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent...://www.in.gov/dnr/water/6401.htm City of Delphi Carroll County Area Plan Commission, Carroll County... Inspection Online at: http://www.in.gov/dnr/water/7339.htm Town of Cumberland Municipal Building, 11501 East...

78 FR 8181 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... panels of experts in hydrology, hydraulics, and other pertinent sciences established to review... Inspection Online at: http://www.in.gov/dnr/water/6476.htm City of Hartford City Blackford County Area... Online at: http://www.in.gov/dnr/water/5775.htm City of Carmel Department of Community Services, One...

77 FR 29678 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent..., and Incorporated Areas Maps Available for Inspection Online at: http://www.in.gov/dnr/water/7293.htm... Online at: http://www.dnr.sc.gov/water/flood/comaps.html City of Manning 29 West Boyce Street, Manning...

77 FR 67016 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other pertinent... at: http://www.in.gov/dnr/water/6644.htm Town of Brookville Franklin County Government Center, Area...://www.in.gov/dnr/water/6415.htm Town of Liberty Union County Area Plan Commission, 6 West South Street...

75 FR 4375 - Transmission Loading Relief Reliability Standard and Curtailment Priorities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... Site: http://www.ferc.gov . Documents created electronically using word processing software should be... ensure operation within acceptable reliability criteria. NERC Glossary of Terms Used in Reliability Standards at 19, available at http://www.nerc.com/files/Glossary_12Feb08.pdf (NERC Glossary). An...

Nano Materials

DTIC Science & Technology

2007-03-01

materials: • Electrical conductivity -- probably the best conductor of electricity on a nanoscale level that can ever be possible. • Thermal ...for high purity nanotubes. RTO-EN-AVT-129bis 3 - 1 van Heeren, H. (2007) Nano Materials. In Nanotechnology Aerospace Applications...2006 (pp. 3- 1 – 3-4). Educational Notes RTO-EN-AVT-129bis, Paper 3. Neuilly-sur-Seine, France: RTO. Available from: http://www.rto.nato.int

Chado Controller: advanced annotation management with a community annotation system

PubMed Central

Guignon, Valentin; Droc, Gaëtan; Alaux, Michael; Baurens, Franc-Christophe; Garsmeur, Olivier; Poiron, Claire; Carver, Tim; Rouard, Mathieu; Bocs, Stéphanie

2012-01-01

Summary: We developed a controller that is compliant with the Chado database schema, GBrowse and genome annotation-editing tools such as Artemis and Apollo. It enables the management of public and private data, monitors manual annotation (with controlled vocabularies, structural and functional annotation controls) and stores versions of annotation for all modified features. The Chado controller uses PostgreSQL and Perl. Availability: The Chado Controller package is available for download at http://www.gnpannot.org/content/chado-controller and runs on any Unix-like operating system, and documentation is available at http://www.gnpannot.org/content/chado-controller-doc The system can be tested using the GNPAnnot Sandbox at http://www.gnpannot.org/content/gnpannot-sandbox-form Contact: valentin.guignon@cirad.fr; stephanie.sidibe-bocs@cirad.fr Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22285827

Enhanced anticancer efficacy and tumor targeting through folate-PEG modified nanoliposome loaded with 5-fluorouracil

NASA Astrophysics Data System (ADS)

Le, Van Minh; Tran Nho, Trung Duc; Trieu Ly, Hai; Vo, Thanh Sang; Dung Nguyen, Hoang; Thu Huong Phung, Thi; Zou, Aihua; Liu, Jianwen

2017-03-01

Cancer targeted therapies have attracted considerable attention over the past year. Recently, 5-fluouracil (5-FU), which has high toxicity to normal cells and short half-life associated with rapid metabolism, is one of the most commonly used therapies in the treatment of cancer. In this study the folic acid-conjugated pegylated nanoliposomes were synthesized and then loaded into them with 5-FU to improve the anti-tumor efficacy. The average size of liposomes (LPs) was about 52.7 nm which was identified by TEM. In the liposome uptake studies, the level uptake of folate-conjugated liposomes has increased compared to non-conjugated LPs according to LPs concentration, incubation time and presence of concentration of free folic acid (FA). The MTT assay and apoptotic test were carried out in HCT116 and MCF-7 cells for 24 or 48 h. The results revealed that the folate-PEG modified 5-Fu loaded nanoliposomes had strong cytotoxicity to cancer cell compared to pure 5-FU or PEG modified 5-FU loaded liposomes in a concentration- and time-dependent manner, and mainly enhanced the cancer cell death through folate-mediated endocytosis. Hence, the folate-PEG modified nanoliposome is a potential targeted drug-delivery system for the treatment of FR-positive cancers.

76 FR 53317 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, and -900 Series...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

...; telephone 760- 466-1040; fax 760-466-1038; Internet http://www.tdgaerospace.com ; e- mail [email protected] March 8, 2011 (76 FR 12634). The original NPRM (72 FR 37479, July 10, 2007) proposed to require... usage restrictions specified in AD 2002-24-51, Amendment 39-12992 (68 FR 10, January 2, 2003), and AD...

Chrysophyllum cainito leaves are effective against pre-clinical chronic pain models: Analysis of crude extract, fraction and isolated compounds in mice.

PubMed

Meira, Nicole Anzanelo; Rocha, Lilian W; da Silva, Gislaine F; Quintal, Zhelmy Martin; Delle Monache, Franco; Cechinel Filho, Valdir; Quintão, Nara Lins Meira

2016-05-26

Chrysophyllum cainito L. (Sapotaceae), commonly known as caimito or star apple, is a neotropical tree valued for its ornamental quality and edible fruits. Besides its culinary use, the leaves are also popularly used to treat diabetes mellitus and several inflammatory diseases. This study aimed to complement previous data obtained about the anti-hypersensitivity effects of the crude methanol extract (CME), CHCl3 fraction and isolated compounds obtained from C. cainito. The CME, CHCl3 fraction and two isolated triterpenes identified as 3β-Lup-20(29)-en-3-yl acetate (1) and Lup-20(29)-en-3β-O-hexanoate (2) were evaluated regarding their effects using clinical pain models, such as post-operative, inflammatory and neuropathic pain. Acute inflammatory pain models induced by PGE2, epinephrine, LPS and CFA were also used to improve the knowledge about the mechanism of action. The animals treated with the CME and submitted to PGE2, epinephrine, LPS or CFA had the mechanical hypersensitivity significantly reduced. When repeatedly administered, the CME enhanced the mechanical withdrawal threshold of mice submitted to post-operative pain model, CFA-induced chronic inflammatory pain and two different models of neuropathic pain. In turn, the CHCl3 fraction presented anti-hypersensitivity effect against epinephrine- or LPS-induced hypersensitivity, with a more prominent activity in both the neuropathic pain models. The compound 1 seems to present the same profile of the CHCl3, whereas compound 2 exhibited activity similar to the CME. This data suggests that the CME effect involves interference in the production, release or action of some chemical mediators, such as PGE2, sympathetic amines, cytokines, etc. Part of these effects was observed with the CHCl3 fraction, emphasizing the prominent inhibition of neuropathic pain. The results also demonstrated that part of the CME effects are due to the presence of the triterpenes 1 and 2, but it is important to mention that we cannot discard the effects of countless other compounds presented in the crude extract, acting in a synergic way. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

10 CFR 1003.14 - Notice of proceedings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Wide Web site, a digest of the applications, appeals, petitions and other requests filed, and a summary... OHA's web site is located at http://www.oha.doe.gov. [60 FR 15006, Mar. 21, 1995, as amended at 63 FR...

10 CFR 1003.14 - Notice of proceedings.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OHA's web site is located at http://www.oha.doe.gov. [60 FR 15006, Mar. 21, 1995, as amended at 63 FR... Wide Web site, a digest of the applications, appeals, petitions and other requests filed, and a summary...

10 CFR 1003.14 - Notice of proceedings.

Code of Federal Regulations, 2014 CFR

2014-01-01

... OHA's web site is located at http://www.oha.doe.gov. [60 FR 15006, Mar. 21, 1995, as amended at 63 FR... Wide Web site, a digest of the applications, appeals, petitions and other requests filed, and a summary...

10 CFR 1003.14 - Notice of proceedings.

Code of Federal Regulations, 2012 CFR

2012-01-01

... OHA's web site is located at http://www.oha.doe.gov. [60 FR 15006, Mar. 21, 1995, as amended at 63 FR... Wide Web site, a digest of the applications, appeals, petitions and other requests filed, and a summary...

10 CFR 1003.14 - Notice of proceedings.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OHA's web site is located at http://www.oha.doe.gov. [60 FR 15006, Mar. 21, 1995, as amended at 63 FR... Wide Web site, a digest of the applications, appeals, petitions and other requests filed, and a summary...

Estudio de la envoltura fría en presencia de un campo magnético en estrellas tempranas

NASA Astrophysics Data System (ADS)

Montero, M. F.; Platzeck, A. M.

En el estudio de la distribución espacial de la densidad en torno a estrellas tempranas, al menos en dos coordenadas, se consideran en general ``escenarios" cualitativos. Existen sólo dos modelos calculados a partir de la ecuación de conservación de momento: el de Poeckert y Marlborough (Astroph. Journal 220, 940, 1978) y el de Ringuelet e Iglesias (Astroph. Journal 369, 463, 1991). El primero es isotermo considerando campo gravitatorio y fuerza centrífuga. El segundo, resuelve un caso no isotermo en equilibrio hidrostático teniendo en cuenta los campos gravitatorios, de radiación y magnético. En esta comunicación presentamos el análisis, que se deriva de los resultados de Ringuelet e Iglesias para el caso hidrostático, de la estructura de líneas de campo magnético. A continuación estudiamos la forma en que se modifica la distribución espacial de la densidad en la envoltura fría, cuando se tiene en cuenta el movimiento del plasma.

Integrando la historia clínica ambiental en el consejo prenatal y cuidado de 2 casos de gastrosquisis

PubMed Central

García, J.A. Ortega; Martín, M.; Lamas, A. Brea; De Paco-Matallana, C.; Jiménez, J.I. Ruiz; Soldin, O.P.

2017-01-01

Introducción La gastroquisis es una malformación de etiología desconocida en la que se han implicado factores de riesgo (FR) genéticos y medioambientales. El objetivo de este trabajo es desarrollar la historia clínica medioambiental pediátrica (HCMAP) de la gastroquisis en 2 pacientes. Pacientes y métodos Revisión bibliográfica en Pubmed y en el Developmental and Reproductive Toxicology Database. Búsqueda selectiva de sustancias con capacidad teratogénica en el Hazardous Substances Data Bank. Palabras clave utilizadas fueron: «gastroschisis» y «gastroschisis and risk factor». Resultados En ambos casos están presentes los siguientes FR descritos en la literatura: corta cohabitación, embarazos no planificados de madres relativamente jóvenes, cambio de pareja reciente, ingesta de alcohol, déficits nutricionales importantes, tabaquismo activo/pasivo. Un caso estuvo expuesto a cocaína, humo de cannabis y se realizó una ortopantografía durante el embarazo. Conclusiones 1) Es necesario obtener la HCMAP en todo paciente con gastroquisis; 2) una cuidadosa HCMAP requiere una adecuada revisión de los FR relacionados e instrucción básica para caracterizar y cuantificar las exposiciones medioambientales, y 3) siguiendo estos pasos, complementaremos nuestras labores asistenciales y preventivas. PMID:20122885

Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

PubMed

Tak, Tamar; Wijten, Patrick; Heeres, Marjolein; Pickkers, Peter; Scholten, Arjen; Heck, Albert J R; Vrisekoop, Nienke; Leenen, Luke P; Borghans, José A M; Tesselaar, Kiki; Koenderman, Leo

2017-06-29

During acute inflammation, 3 neutrophil subsets are found in the blood: neutrophils with a conventional segmented nucleus, neutrophils with a banded nucleus, and T-cell-suppressing CD62L dim neutrophils with a high number of nuclear lobes. In this study, we compared the in vivo kinetics and proteomes of banded, mature, and hypersegmented neutrophils to determine whether these cell types represent truly different neutrophil subsets or reflect changes induced by lipopolysaccharide (LPS) activation. Using in vivo pulse-chase labeling of neutrophil DNA with 6,6- 2 H 2 -glucose, we found that 2 H-labeled banded neutrophils appeared much earlier in blood than labeled CD62L dim and segmented neutrophils, which shared similar label kinetics. Comparison of the proteomes by cluster analysis revealed that CD62L dim neutrophils were clearly separate from conventional segmented neutrophils despite having similar kinetics in peripheral blood. Interestingly, the conventional segmented cells were more related at a proteome level to banded cells despite a 2-day difference in maturation time. The differences between CD62L dim and mature neutrophils are unlikely to have been a direct result of LPS-induced activation, because of the extremely low transcriptional capacity of CD62L dim neutrophils and the fact that neutrophils do not directly respond to the low dose of LPS used in the study (2 ng/kg body weight). Therefore, we propose CD62L dim neutrophils are a truly separate neutrophil subset that is recruited to the bloodstream in response to acute inflammation. This trial was registered at www.clinicaltrials.gov as #NCT01766414. © 2017 by The American Society of Hematology.

78 FR 29624 - Rules on Determining Hearing Appearances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-21

... with final rules we published in the Federal Register on December 18, 2008 (73 FR 76940) \\2\\ and July 8...-20690.pdf . \\2\\ The final rules are available at: http://www.gpo.gov/fdsys/pkg/FR-2008-12-18/pdf/E8... hearing, whether in person, by video teleconferencing, or by telephone. If the ALJ determines that any...

5 CFR 1201.153 - Contents of appeal.

Code of Federal Regulations, 2010 CFR

2010-01-01

... information marked as required at the e-Appeal site (https://e-appeal.mspb.gov). MSPB Form 185 can be accessed at the Board's Web site (http://www.mspb.gov). [54 FR 53504, Dec. 29, 1989, as amended at 68 FR 59864...

5 CFR 1201.153 - Contents of appeal.

Code of Federal Regulations, 2011 CFR

2011-01-01

... information marked as required at the e-Appeal site (https://e-appeal.mspb.gov). MSPB Form 185 can be accessed at the Board's Web site (http://www.mspb.gov). [54 FR 53504, Dec. 29, 1989, as amended at 68 FR 59864...

5 CFR 1201.153 - Contents of appeal.

Code of Federal Regulations, 2012 CFR

2012-01-01

... information marked as required at the e-Appeal site (https://e-appeal.mspb.gov). MSPB Form 185 can be accessed at the Board's Web site (http://www.mspb.gov). [54 FR 53504, Dec. 29, 1989, as amended at 68 FR 59864...

5 CFR 1201.153 - Contents of appeal.

Code of Federal Regulations, 2013 CFR

2013-01-01

... marked as required at the e-Appeal site (https://e-appeal.mspb.gov). MSPB Form 185 can be accessed at the Board's Web site (http://www.mspb.gov). [54 FR 53504, Dec. 29, 1989, as amended at 68 FR 59864, Oct. 20...

Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages.

PubMed

Yao, Xue; Wu, Dang; Dong, Ningning; Ouyang, Ping; Pu, Jiaqian; Hu, Qian; Wang, Jingyuan; Lu, Weiqiang; Huang, Jin

2016-07-25

Artocarpus heterophyllus, a popular tropical fruit commonly known as the jackfruit tree, is normally planted in subtropical or tropical areas. Since a variety of phytochemicals isolated from A. heterophyllus have been found to possess potently anti-inflammatory, antiviral and antimalarial activities, researchers have devoted much interest to its potential pharmaceutical value. However, the exact mechanism underlying its anti-inflammatory activity is not well characterized. In this study, seven natural products isolated from A. heterophyllus, including 25-Hydroxycycloart-23-en-3-one (HY), Artocarpin (AR), Dadahol A (DA), Morachalcone A (MA), Artoheterophyllin B (AB), Cycloheterophyllin (CY) and Moracin C (MC) were collected. Lipopolysaccharide (LPS)-stimulated inflammatory response in RAW264.7 macrophages were used in this study. Among these compounds, MC significantly inhibited LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release without marked cytotoxicity. Furthermore, MC effectively reduced LPS stimulated up-regulation of mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and serval pro-inflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)). Mechanistic studies revealed that the anti-inflammatory effect of MC was associated with the activation of the mitogen activated protein kinases (MAPKs) (including p38, ERK and JNK) and nuclear factor-κB (NF-κB) pathways, especially reducing the nuclear translocation of NF-κB p65 subunit as revealed by nuclear separation experiment and confocal microscopy.

Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages

PubMed Central

Yao, Xue; Wu, Dang; Dong, Ningning; Ouyang, Ping; Pu, Jiaqian; Hu, Qian; Wang, Jingyuan; Lu, Weiqiang; Huang, Jin

2016-01-01

Artocarpus heterophyllus, a popular tropical fruit commonly known as the jackfruit tree, is normally planted in subtropical or tropical areas. Since a variety of phytochemicals isolated from A. heterophyllus have been found to possess potently anti-inflammatory, antiviral and antimalarial activities, researchers have devoted much interest to its potential pharmaceutical value. However, the exact mechanism underlying its anti-inflammatory activity is not well characterized. In this study, seven natural products isolated from A. heterophyllus, including 25-Hydroxycycloart-23-en-3-one (HY), Artocarpin (AR), Dadahol A (DA), Morachalcone A (MA), Artoheterophyllin B (AB), Cycloheterophyllin (CY) and Moracin C (MC) were collected. Lipopolysaccharide (LPS)-stimulated inflammatory response in RAW264.7 macrophages were used in this study. Among these compounds, MC significantly inhibited LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release without marked cytotoxicity. Furthermore, MC effectively reduced LPS stimulated up-regulation of mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and serval pro-inflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)). Mechanistic studies revealed that the anti-inflammatory effect of MC was associated with the activation of the mitogen activated protein kinases (MAPKs) (including p38, ERK and JNK) and nuclear factor-κB (NF-κB) pathways, especially reducing the nuclear translocation of NF-κB p65 subunit as revealed by nuclear separation experiment and confocal microscopy. PMID:27463712

76 FR 76070 - Proposed Modification of Area Navigation Route T-288; WY

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

.... 11-ANM-14 at the beginning of your comments. You may also submit comments through the Internet at... also submit comments through the Internet at http://www.regulations.gov . Commenters wishing the FAA to... copy of this document may be downloaded through the Internet at http://www.regulations.gov . Recently...

75 FR 4603 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... Protection and Locked/ Crossed Market Plan (``Decentralized Plan'').\\6\\ In particular, the Commission...: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or... Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml...

77 FR 18283 - Self-Regulatory Organizations; The National Securities Clearing Corporation; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

.... NSCC believes it can offer a number of control improvements to the current manual, decentralized, and...: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or... one method. The Commission will post all comments on the Commission's Internet Web site ( http://www...

77 FR 22806 - Notice of Availability of Funds and Solicitation for Grant Applications for Cooperative...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... and adults with disabilities who are unemployed, underemployed, and/or receiving Social Security... connection with this solicitation are described in further detail on ETA's Web site at http://www.doleta.gov/grants/ or on http://www.grants.gov . The Web sites provide application information, eligibility...

77 FR 38584 - Oil and Gas Trade Mission to Israel-Clarification and Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

....zhtml?c=160695&p=irol-newsArticle&ID=1464492&highlight= . [7] ``Oil Shale Country Notes: Israel.'' World....'' Globes Israel Business News. 13 Mar. 2012. http://www.globes.co.il/serveen/globes/docview.asp?did... Field Development.'' Globes Israel Business News, 30 Jan. 2012. http://www.globes.co.il/serveen/globes...

78 FR 2987 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

.... For a recorded message listing items struck from or added to the meeting, call (202) 502-8627. This is... D. Bose, Secretary. A free webcast of this event is available through www.ferc.gov . Anyone with Internet access who desires to view this event can do so by navigating to www.ferc.gov 's Calendar of...

77 FR 52702 - Notice of Availability of Record of Decision for the Silver Strand Training Complex, California

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... of Decision is available for public viewing on the project Web site at http://www... Decision are available by contacting: Ms. Amy P. Kelley, Naval Facilities Engineering Command Southwest... project Web site is found at http://www.silverstrandtrainingcomplexeis.com . Dated: August 24, 2012. C. K...

77 FR 15980 - Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-19

[email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may review copies of the referenced service... 7070; fax: 011 64 7843 8040; email: [email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may review copies of the referenced service information at the FAA, Small Airplane...

77 FR 33622 - Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

[email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may review copies of the referenced service... 8040; email: [email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may... 64 7 843 7070; fax: 011 64 7843 8040; email: [email protected]nz ; Internet: http...

75 FR 9014 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... by electronic means via the Internet at http://www.regulations.gov/search/index.jsp . Specifically... the World Wide Web at http://www.regulations.gov/search/index.jsp . Privacy Act: Anyone is able to.../index.jsp . Authority: 49 CFR 1.66. Dated: February 2, 2010. By Order of the Maritime Administrator...

75 FR 33884 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... by electronic means via the Internet at http://www.regulations.gov ./search/index.jsp. Specifically... the World Wide Web at http://www.regulations.gov/search/index.jsp . Privacy Act: Anyone is able to....regulations.gov/search/index.jsp . Authority: 49 CFR 1.66. By Order of the Maritime Administrator. Dated: June...

75 FR 78340 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

.../search/index.jsp . Specifically address whether this information collection is necessary for proper... version of this document is available on the World Wide Web at http://www.regulations.gov/search/index.jsp... visit http://www.regulations.gov/search/index.jsp . (Authority: 49 CFR 1.66) By Order of the Maritime...

76 FR 28845 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... ./search/index.jsp. Specifically address whether this information collection is necessary for proper... version of this document is available on the World Wide Web at http://www.regulations.gov/search/index,jsp... visit http://www.regulations.gov/search/index.jsp . Authority: 49 CFR 1.66. Dated: May 9, 2011. By Order...

76 FR 6181 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... may be submitted by electronic means via the Internet at http://www.regulations.gov/search/index.jsp... is available on the World Wide Web at http://www.regulations.gov/search/index.jsp . Privacy Act....regulations.gov/search/index.jsp . By order of the Maritime Administrator. Dated: January 24, 2011. Christine...

75 FR 35876 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... electronic means via the Internet at http://www.regulations.gov/search/index.jsp . Specifically address... the World Wide Web at http://www.regulations.gov/search/index.jsp . Privacy Act: Anyone is able to.../index.jsp . Authority: 49 CFR 1.66. By Order of the Maritime Administrator. Dated: June 17, 2010. Julie...

78 FR 3370 - Proposed Establishment of the Ballard Canyon Viticultural Area

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... the origin of their wines and to allow consumers to better identify wines they may purchase. TTB... the TTB Web site at http://www.ttb.gov/wine/wine_rulemaking.shtml "> http://www.ttb.gov/wine/wine... Secretary of the Treasury to prescribe regulations for the labeling of wine, distilled spirits, and malt...

48 CFR 225.301-4 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Predeployment and Operational Tracker (SPOT) is the appropriate automated system to use for the list of contractor personnel required by paragraph (g) of the clause. Information on the SPOT system is available at http://www.dod.mil/bta/products/spot.html and http://www.acq.osd.mil/log/PS/spot.html. [73 FR 16774...

48 CFR 225.301-4 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Predeployment and Operational Tracker (SPOT) is the appropriate automated system to use for the list of contractor personnel required by paragraph (g) of the clause. Information on the SPOT system is available at http://www.dod.mil/bta/products/spot.html and http://www.acq.osd.mil/log/PS/spot.html. [73 FR 16774...

48 CFR 225.301-4 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Predeployment and Operational Tracker (SPOT) is the appropriate automated system to use for the list of contractor personnel required by paragraph (g) of the clause. Information on the SPOT system is available at http://www.dod.mil/bta/products/spot.html and http://www.acq.osd.mil/log/PS/spot.html. [73 FR 16774...

48 CFR 225.301-4 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Predeployment and Operational Tracker (SPOT) is the appropriate automated system to use for the list of contractor personnel required by paragraph (g) of the clause. Information on the SPOT system is available at http://www.dod.mil/bta/products/spot.html and http://www.acq.osd.mil/log/PS/spot.html. [73 FR 16774...

48 CFR 225.301-4 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Predeployment and Operational Tracker (SPOT) is the appropriate automated system to use for the list of contractor personnel required by paragraph (g) of the clause. Information on the SPOT system is available at http://www.dod.mil/bta/products/spot.html and http://www.acq.osd.mil/log/PS/spot.html. [73 FR 16774...

75 FR 51978 - United States Standards for Grades of Pineapple Juice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

...: Effective Date: August 24, 2010. FOR FURTHER INFORMATION CONTACT: Lydia E. Berry, Processed Products Branch... Juice are located on the Internet at: http://www.regulations.go v or http://www.ams.usda.gov... in part 36, title 7 of the Code of Federal Regulations (7 CFR part 36). These corrections restore the...

76 FR 19285 - Request for Information Regarding Electronic Disclosure by Employee Benefit Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

..., fiber optic and wireless networks; hardware improvements to servers and personal computers improving... electronic media. For instance, the 2009 U.S. Census Bureau Current Population Survey (Census) found that 76.... \\3\\ The Census information may be found at http://www.census.gov/population/www/socdemo/computer.html...

76 FR 31299 - Request for Applications for the Veterinary Medicine Loan Repayment Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... release of the Veterinary Medicine Loan Repayment Program (VMLRP) Request for Applications (RFA) at http...) application package has been made available at http://www.nifa.usda.gov/vmlrp and applications are due by... Education. The NSLDS website can be found at http://www.nslds.ed.gov . Individuals who consolidated their...

77 FR 9219 - Environmental Management Site-Specific Advisory Board, Oak Ridge Reservation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

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75 FR 8155 - Sunshine Act; Notice of Meeting

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2010-02-23

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75 FR 6413 - Sunshine Act Meeting Notice

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2010-02-09

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77 FR 35081 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

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2010-01-05

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2010-09-20

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2012-01-26

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Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

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78 FR 57645 - Changes in Flood Hazard Determinations

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2011-05-20

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75 FR 20879 - Tireco, Inc., Receipt of Petition for Decision of Inconsequential Noncompliance

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2011-12-07

... Activities; Submission to OMB for Review and Approval; Comment Request; NESHAP for Cellulose Products... in paper, will be made available for public viewing at http://www.regulations.gov as EPA receives... information about the electronic docket, go to http://www.regulations.gov . Title: NESHAP for Cellulose...

76 FR 23225 - Modification of Regulations Regarding the Practice of Accepting Bonds During the Provisional...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... online at http://www.Regulations.gov and on the Department's Web site at http://www.trade.gov/ia/ . Any questions concerning file formatting, document conversion, access on the Internet, or other electronic... system, for the provisional measure period an estimated antidumping or countervailing duty rate is...

76 FR 70919 - Proposed Amendment of Class D and Class E Airspace, and Establishment of Class E Airspace...

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2011-11-16

.... You may also submit comments through the Internet at http://www.regulations.gov . FOR FURTHER..., economic, environmental, and energy-related aspects of the proposal. Communications should identify both... submit comments through the Internet at http://www.regulations.gov . Commenters wishing the FAA to...

76 FR 68748 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

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2011-11-07

... Requirements for Importation of Nonroad Engines and Recreational Vehicles (Renewal) AGENCY: Environmental... and Radiation Docket is (202) 566-1742. Use EPA's electronic docket and comment system at http://www... disclosure is restricted by statute. For further information about the electronic docket, go to http://www...

76 FR 68043 - Federal Acquisition Regulation; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

...), and National Aeronautics and Space Administration (NASA). ACTION: Final rule. SUMMARY: This document... Acquisition Policy, Office of Governmentwide Policy. Therefore, DoD, GSA, and NASA amend 48 CFR parts 1 and 8...] 0 4. Amend section 8.501 by removing ``http://www.nm.blm.gov/www/amfo/ amfo_home.html'' and adding...

75 FR 48393 - Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... the proposed rule change is available on NFA's Web site at http://www.nfa.futures.org , at the... same results and any differences between them are largely semantic. The Committees noted, however, that... Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the submission, all...

78 FR 64929 - National Advisory Committee on Institutional Quality and Integrity (NACIQI)

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2013-10-30

... process for institutions of higher education under Title IV, of the HEA, together with recommendations for... Federal Register and the Code of Federal Regulations is available via the Federal Digital System at: www... of the Department published in the Federal Register by using the article search feature at: www...

78 FR 19695 - National Advisory Committee on Institutional Quality and Integrity (NACIQI)

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2013-04-02

... of higher education under Title IV, of the HEA, together with recommendations for improvement in such... available via the Federal Digital System at: www.gpo.gov/fdsys . At this site you can view this document, as... the article search feature at: www.federalregister.gov . Specifically, through the advanced search...

77 FR 64493 - National Advisory Committee on Institutional Quality and Integrity (NACIQI)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

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75 FR 52305 - Notice of Availability of a Treatment Evaluation Document

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

...: Additional information about APHIS and its programs is available on the Internet at ( http://www.aphis.usda... other things, to prevent the introduction or dissemination of plant pests and noxious weeds into or.... 305.3(b)(1). \\a\\ The Treatment Manual is available on the Internet at ( http://www.aphis.usda.gov...

78 FR 25129 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Proposed...

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2013-04-29

... provide guaranteed settlement and central counterparty services,\\10\\ which among other things established... following methods: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules... method. The Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov...

77 FR 29953 - Application of Buy America Waivers to Rolling Stock Overhauls and Rebuilds

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2012-05-21

...: Go to http://www.regulations.gov . Follow the online instructions for submitting comments. U.S. Mail... without change or alteration to http://www.regulations.gov . For more information, you may review DOT's... procurements, including the purchase of new vehicles, overhauls, and rebuilds. The waiver allows up to 40...

76 FR 67456 - Common Formats for Patient Safety Data Collection and Event Reporting

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2011-11-01

... Common Formats, can be accessed electronically at the following HHS Web site: http://www.PSO.AHRQ.gov... Thromboembolism (VTE), which includes Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), will apply to both... available at the PSO Privacy Protection Center (PPC) Web site: https://www.psoppc.org/web/patientsafety...

77 FR 36583 - NRC Form 5, Occupational Dose Record for a Monitoring Period

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2012-06-19

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76 FR 31884 - Reducing Regulatory Burden; Retrospective Review Plans Under E.O. 13563

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

... agencies have been posted on the White House Web site at: http://www.slideshare.net/whitehouse/hud-combined... effective and less burdensome in achieving HUD's mission to create strong, sustainable, inclusive... House Web site at: http://www.slideshare.net/whitehouse/hud-combined . The appendix to HUD's plan...

33 CFR 401.74 - Transit declaration.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Lambert, Quebec, J4R 2V6 or from the St. Lawrence Seaway Web site at http://www.greatlakes-seaway.com. (b..., as amended and secs. 4, 5, 6, 7, 8, 12 and 13 of sec. 2 of Pub. L. 95-474, 92 Stat. 1471) [39 FR 10900, Mar. 22, 1974, as amended at 48 FR 20691, May 9, 1983; 49 FR 30936, Aug. 2, 1984; 65 FR 52914...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Office of Cargo Preference 400 7th Street, SW. Washington, DC 20590 http://www.marad.dot.gov/ Tel. 1-800-9US-FLAG e-mail: [email protected]gov [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000] ...

[Chronic kidney disease and kidney transplantation].

PubMed

Thuret, R; Timsit, M O; Kleinclauss, F

2016-11-01

To report epidemiology and characteristics of end-stage renal disease (ESRD) patients and renal transplant candidates, and to evaluate access to waiting list and results of renal transplantation. An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords: "chronic kidney disease, epidemiology, kidney transplantation, cost, survival, graft, brain death, cardiac arrest, access, allocation". French legal documents have been reviewed using the government portal (http://www.legifrance.gouv.fr). Articles were selected according to methods, language of publication and relevance. The reference lists were used to identify additional historical studies of interest. Both prospective and retrospective series, in French and English, as well as review articles and recommendations were selected. In addition, French national transplant and health agencies (http://www.agence-biomedecine.fr and http://www.has-sante.fr) databases were screened using identical keywords. A total of 3234 articles, 6 official reports and 3 newspaper articles were identified; after careful selection 99 publications were eligible for our review. The increasing prevalence of chronic kidney disease (CKD) leads to worsen organ shortage. Renal transplantation remains the best treatment option for ESRD, providing recipients with an increased survival and quality of life, at lower costs than other renal replacement therapies. The never-ending lengthening of the waiting list raises issues regarding treatment strategies and candidates' selection, and underlines the limits of organ sharing without additional source of kidneys available for transplantation. Allocation policies aim to reduce medical or geographical disparities regarding enrollment on a waiting list or access to an allotransplant. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

20 CFR 411.565 - What happens if two or more ENs qualify for payment on the same ticket but have elected different...

Code of Federal Regulations, 2010 CFR

2010-04-01

... ticket but have elected different EN payment systems? We will pay each EN (or State VR agency acting as... ticket to the EN (or the State VR agency acting as an EN). [73 FR 29350, May 20, 2008] ...

20 CFR 411.565 - What happens if two or more ENs qualify for payment on the same ticket but have elected different...

Code of Federal Regulations, 2011 CFR

2011-04-01

... ticket but have elected different EN payment systems? We will pay each EN (or State VR agency acting as... ticket to the EN (or the State VR agency acting as an EN). [73 FR 29350, May 20, 2008] ...

Post-ruminal branched-chain amino acid supplementation and intravenous lipopolysaccharide infusion alters blood metabolites, rumen fermentation, and nitrogen balance of beef steers.

PubMed

Löest, C A; Gilliam, G G; Waggoner, J W; Turner, J L

2018-04-27

Steers exposed to an endotoxin may require additional branched-chain AA (BCAA) to support an increase in synthesis of immune proteins. This study evaluated effects of bacterial lipopolysaccharide (LPS) and BCAA supplementation on blood metabolites and N balance of 20 ruminally-cannulated steers (177 ± 4.2 kg BW). The experiment was a randomized block design, with 14-d adaptation to metabolism stalls and diet (DM fed = 1.5% BW) and 6-d collection. Treatments were a 2 × 2 factorial of LPS (0 vs 1.0 to 1.5 μg/kg BW; -LPS vs +LPS) and BCAA (0 vs 35 g/d; -BCAA vs +BCAA). The LPS in 100 mL sterile saline was infused (1 mL/min via i.v. catheter) on d 15. The BCAA in an essential AA solution were abomasally infused (900 mL/d) 3 times daily in equal portions beginning on d 7. Blood, rumen fluid, and rectal temperature were collected on d 15 at h 0, 2, 4, 8, 12, and 24 after LPS infusion. Feces and urine were collected from d 16 to 20. Rectal temperatures were greater for +LPS vs. -LPS steers at 4 h and lower at 8 h after LPS infusion (LPS h, P < 0.01). Serum cortisol and plasma urea N were greater for +LPS than -LPS steers at 2 (cortisol only), 4, 8, 12, and 24 h after LPS infusion (LPS × h, P < 0.01). Serum cortisol was greater for +BCAA than -BCAA steers at 12 h after LPS infusion (BCAA × h, P < 0.05). Serum glucose was greater for +LPS than -LPS steers at 2 h after LPS infusion (LPS × h, P < 0.01). Plasma Ile, Leu, and Val were lower, and plasma His was greater in +LPS than -LPS steers (LPS, P < 0.05). Plasma Lys, Met, Thr, and Trp of +LPS steers was lower than -LPS steers at 4 (Thr only), 8 (Lys and Trp only), 12, and 24 h after infusion (LPS × h, P < 0.05). Plasma Ile, Leu, and Val were greater (BCAA, P < 0.01), and Met, His, Phe, Thr, and Trp were lower for +BCAA than -BCAA steers at 0 h and 24 h after LPS infusion (BCAA × h, P ≤ 0.05). Steers receiving +LPS had lower rumen pH at 8 h, greater total VFA at 8 h, and lower rumen NH3 at 24 h after LPS infusion compared with -LPS steers (LPS × h, P ≤ 0.04). Total tract passage rates, DM, OM, NDF, ADF, and N intake, fecal N, digested N, and retained N were lower (P < 0.05) for +LPS than -LPS steers. Total N supply (dietary plus infused) and fecal N were greater (P < 0.05) for +BCAA vs -BCAA steers. The absence of LPS × BCAA interactions (P ≥ 0.20) for N balance indicated that post-ruminal supplementation of BCAA did not alleviate the negative effects of endotoxin on N utilization by growing steers.

Disaggregation of lipopolysaccharide by albumin, hemoglobin or high-density lipoprotein, forming complexes that prime neutrophils for enhanced release of superoxide.

PubMed

Komatsu, Toshiya; Aida, Yoshitomi; Fukuda, Takao; Sanui, Terukazu; Hiratsuka, Shunji; Pabst, Michael J; Nishimura, Fusanori

2016-04-01

We studied the interaction of LPS with albumin, hemoglobin or high-density lipoprotein (HDL), and whether the interaction affected the activity of LPS on neutrophils. These proteins disaggregated LPS, depending upon temperature and LPS:protein ratio. Albumin-treated LPS was absorbed by immobilized anti-albumin antibody and was eluted with Triton X-100, indicating that LPS formed a hydrophobic complex with albumin. Rd mutant LPS was not disaggregated by the proteins, and did not form a complex with the proteins. But triethylamine-treated Rd mutant LPS formed complexes. When LPS was incubated with an equal concentration of albumin and with polymyxin B (PMXB), PMXB-LPS-protein three-way complexes were formed. After removal of PMXB, the complexes consisted of 11-15 LPS monomers bound to one albumin or hemoglobin molecule. LPS primed neutrophils for enhanced release of formyl peptide-stimulated superoxide, in a serum- and LPS-binding protein (LBP)-dependent manner. Although LPS plus LBP alone did not prime neutrophils, albumin-, hemoglobin- or HDL-treated LPS primed neutrophils when added with LBP. Triethylamine-treated Rd mutant LPS primed neutrophils only when incubated with one of the proteins and with LBP. Thus, in addition to LBP, disaggregation and complex formation of LPS with one of these proteins is required for LPS to prime neutrophils. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Instrumentation and monitoring of the nextgen road infrastructure: Some results and perspectives from the R5G project

NASA Astrophysics Data System (ADS)

Hautière, Nicolas; Bourquin, Frédéric

2017-04-01

Through the centuries, the roads - which today constitute in France a huge transport network of 1 millions kilometers length - have always been able to cope with society needs and challenges. As a consequence, the next generation road infrastructure will have to take into account at least three societal transitions: ecological, energetic and digital. The goal of the 5th generation road project (R5G©) [1], led by Ifsttar in France, aligned with the Forever Open program [2], is to design and build demonstrators of such future road infrastructures. The goal of this presentation is to present different results related to the greening of road materials [3], the design of energy-positive roads [4, 5], the test of roads that self-diagnose [6], the design of roads adapted for connected [7], autonomous [8] and electrified vehicles [9], etc. In terms of perspectives, we will demonstrate that the road infrastructures will soon become a complex system: On one side road users will benefit from new services, on the other side such massively connected and instrumented infrastructures will potentially become an opportune sensor for knowledge development in geoscience, such as air quality, visibility and fog monitoring. References: [1] R5G project. r5g.ifsttar.fr [2] Forever Open Road project. www.foreveropenroad.eu [3] Biorepavation project. www.infravation.net/projects/BIOREPAVATION [4] N. Le Touz, J. Dumoulin. Numerical study of the thermal behavior of a new deicing road structure design with energy harvesting capabilities. EGU General Assembly 2015, Apr 2015, Vienne, Austria. [5] S. Asfour, F. Bernardin, E. Toussaint, J.-M. Piau. Hydrothermal modeling of porous pavement for its surface de-freezing. Applied Thermal Engineering. Volume 107, 25 August 2016, Pages 493-500 [6] LGV BPL Instrumentation. http://railenium.eu/wp-content/uploads/2016/08/INSTRUMENTATION-BPL-FR.pdf [7] SCOOP@F project. https://ec.europa.eu/inea/en/connecting-europe-facility/cef-transport/projects-by-country/multi-country/2014-eu-ta-0669-s [8] J. Ehrlich, D. Gruyer, O. Orfila, N. Hautière. Autonomous vehicle : The concept of high quality of service highway. FISITA World congress, Busan, Korea, 2016. [9] FABRIC project. www.fabric-project.eu

Delayed Puberty

MedlinePlus

... which make sex hormones • Genetic problems such as Turner syndrome in girls or Klinefelter syndrome in boys • Some ... FS_MH_Klinefelter_Syndrome_EN-6-12.pdf ——Turner Syndrome: www.hormone.org/Resources/upload/ FS_GD_Turner_ ...

Genetic Characterization of a Sinorhizobium meliloti Chromosomal Region Involved in Lipopolysaccharide Biosynthesis

PubMed Central

Lagares, Antonio; Hozbor, Daniela F.; Niehaus, Karsten; Otero, Augusto J. L. Pich; Lorenzen, Jens; Arnold, Walter; Pühler, Alfred

2001-01-01

The genetic characterization of a 5.5-kb chromosomal region of Sinorhizobium meliloti 2011 that contains lpsB, a gene required for the normal development of symbiosis with Medicago spp., is presented. The nucleotide sequence of this DNA fragment revealed the presence of six genes: greA and lpsB, transcribed in the forward direction; and lpsE, lpsD, lpsC, and lrp, transcribed in the reverse direction. Except for lpsB, none of the lps genes were relevant for nodulation and nitrogen fixation. Analysis of the transcriptional organization of lpsB showed that greA and lpsB are part of separate transcriptional units, which is in agreement with the finding of a DNA stretch homologous to a “nonnitrogen” promoter consensus sequence between greA and lpsB. The opposite orientation of lpsB with respect to its first downstream coding sequence, lpsE, indicated that the altered LPS and the defective symbiosis of lpsB mutants are both consequences of a primary nonpolar defect in a single gene. Global sequence comparisons revealed that the greA-lpsB and lrp genes of S. meliloti have a genetic organization similar to that of their homologous loci in R. leguminosarum bv. viciae. In particular, high sequence similarity was found between the translation product of lpsB and a core-related biosynthetic mannosyltransferase of R. leguminosarum bv. viciae encoded by the lpcC gene. The functional relationship between these two genes was demonstrated in genetic complementation experiments in which the S. meliloti lpsB gene restored the wild-type LPS phenotype when introduced into lpcC mutants of R. leguminosarum. These results support the view that S. meliloti lpsB also encodes a mannosyltransferase that participates in the biosynthesis of the LPS core. Evidence is provided for the presence of other lpsB-homologous sequences in several members of the family Rhizobiaceae. PMID:11157937

77 FR 76139 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... happen because of a temporary systems outage, a communications issue between the electronic and floor... Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or Send an email to rule-comments... Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml...

76 FR 9636 - Notice of Open Public Hearing and Roundtable Discussion

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2011-02-18

... China's domestic economic, social and security issues and how the Chinese government is addressing them... obtained from the USCC Web Site http://www.uscc.gov . Date and Time: Friday, February 25, 2011, 8:45 a.m... to the Commission's Web Site at http://www.uscc.gov as soon as available. ADDRESSES: The hearing will...

78 FR 5471 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

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2013-01-25

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2012-1091] Availability of Draft... USCG- 2012-1091 using any one of the following methods: (1) Federal eRulemaking Portal: http://www... Draft EA (document USCG-2012-1091- 0002) in our online docket at http://www.regulations.gov . Also, the...

75 FR 5781 - David Noland; Notice of Declaration of Intention and Soliciting Comments, Protests, and/or...

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2010-02-04

...: //[email protected]net . i. FERC Contact: Any questions on this notice should be addressed to... filings, please go to the Commission's Web site located at http://www.ferc.gov .filing-comments.asp... access the document. You may also register online at http://www.ferc.gov/docs-filing/esubscription.asp to...

77 FR 68820 - Designation of Four (4) Individuals and Five (5) Entities Pursuant to Executive Order 13628 of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... concerning OFAC are available from OFAC's Web site ( www.treasury.gov/ofac ) or via facsimile through a 24..., RASOUL), 90 Park Ave, Farahzadi St, Tehran, Iran; DOB 19 Aug 1961; POB Eghlid, Fars Province, Iran; Web site http://www.jalili.ir ; alt. Web site [[Page 68821

77 FR 16833 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... Activities; Submission to OMB for Review and Approval; Comment Request; NSPS for Hot Mix Asphalt Facilities... in paper, will be made available for public viewing at http://www.regulations.gov as EPA receives... information about the electronic docket, go to www.regulations.gov . Title: NSPS for Hot Mix Asphalt...

76 FR 58268 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... simplify some assumptions and to make estimation methods consistent; and characterization as Agency burden...-1007 to (1) EPA online using http://www.regulations.gov (our preferred method), by e-mail to oppt.ncic...-HQ-OPPT-2010-1007, which is available for online viewing at http://www.regulations.gov , or in person...

76 FR 75849 - Approval and Promulgation of Implementation Plans; Georgia; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... public docket without change and may be made available online at http://www.regulations.gov , including... public docket and made available on the Internet. If you submit an electronic comment, EPA recommends... additional information about EPA's public docket visit the EPA Docket Center homepage at http://www.epa.gov...

78 FR 5156 - Drawbridge Operation Regulation; Christina River, Wilmington, DE

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... near one another and the few vessels that do transit this waterway usually go through all three bridges... your comment online, go to http://www.regulations.gov , type the docket number (USCG-2012-1085) in the..., go to http://www.regulations.gov , type the docket number (USCG-2012-1085) in the ``SEARCH'' box and...

78 FR 1624 - Fall 2012 Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-08

...The Environmental Protection Agency (EPA) publishes the semiannual regulatory agenda online (the e-Agenda) at http:// www.reginfo.gov and at www.regulations.gov to update the public about: Regulations and major policies currently under development; reviews of existing regulations and major policies; and rules and major policy makings completed or canceled since the publication of the last agenda.

77 FR 69455 - Proposed Recommendations Regarding Money Market Mutual Fund Reform

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

... share and other factors as discussed below. MMFs' activities and practices give rise to a structural...'' (Oct. 25, 2012), available at http://www.ici.org/research/stats/mmf . MMFs are a convenient and cost... http://www.ici.org/research/stats/mmf ; ICI Fact Book, at Table 39. \\6\\ See ICI Fact Book, at Table 5...

77 FR 4547 - Federal Perkins Loan, Federal Work-Study, and Federal Supplemental Educational Opportunity Grant...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-30

... information on the Information for Financial Aid Professionals (IFAP) Web site at: www.ifap.ed.gov . Deadline... the FISAP at the following Web site: www.cbfisap.ed.gov . 2. The 2011-2012 Fiscal Operations The FISAP is located at the October 1, 2012. Report and 2013-2014 Application to following Web site...

75 FR 34451 - Public Meeting of the Presidential Commission for the Study of Bioethical Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

...., Suite C-100, Washington, DC 20005. Telephone: 202/233-3960. E-mail: [email protected]bioethics.gov . Web site: http://www.bioethics.gov . SUPPLEMENTARY INFORMATION: The meeting agenda will be posted at http://www.bioethics.gov . The Commission encourages public comment, either in person or in writing. Interested members...

77 FR 42258 - Notice of Funding Availability (NOFA) of Applications for Section 514 Farm Labor Housing Loans...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... Home Builders (NAHB) ICC 700-2008 National Green Building Standard TM: http://www.nahb.org . --Bronze...://www1.eere.energy.gov/builders/challenge/ and Participation in local green/energy efficient building..., Green Communities, LEED for Homes or NAHB's National Green Building Standard (ICC-700) 2008, receive at...

78 FR 30854 - Notice of Funding Availability (NOFA) for Loan Guarantees Under Section 538 Guaranteed Rural...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

... program by the U.S. Green Building Council (USGBC) ( www.usgbc.org )--Certified (10 points), Silver (12...- 2008--National Green Building StandardTM ( www.nahb.org )--Bronze (10 points), Silver (12 points), Gold (15 points), or Emerald (25 points); or A State or local green building program--2 points. (B...

77 FR 64494 - Environmental Management Site-Specific Advisory Board, Oak Ridge Reservation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

...: Department of Energy Information Center, Office of Science and Technical Information, 1 Science.gov Way, Oak...-3315; Fax (865) 576-0956 or email: [email protected]gov or check the Web site at www.oakridge.doe.gov/em... following Web site: http://www.oakridge.doe.gov/em/ssab/minutes.htm . [[Page 64495

78 FR 23241 - Environmental Management Site-Specific Advisory Board, Oak Ridge Reservation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... of Energy Information Center, Office of Science and Technical Information, 1 Science.gov Way, Oak...-3315; Fax (865) 576-0956 or email: [email protected]gov or check the Web site at www.oakridge.doe.gov/em... also be available at the following Web site: http://www.oakridge.doe.gov/em/ssab/minutes.htm . Issued...

77 FR 49442 - Environmental Management Site-Specific Advisory Board, Oak Ridge Reservation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

...: Department of Energy Information Center, Office of Science and Technical Information, 1 Science.gov Way, Oak...-3315; Fax (865) 576-0956 or email: [email protected]gov or check the Web site at www.oakridge.doe.gov/em... following Web site: http://www.oakridge.doe.gov/em/ssab/minutes.htm . [[Page 49443

77 FR 56775 - Approval and Promulgation of Implementation Plans; California; Determinations of Attainment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... its Technical System Audit of the CARB PQAO (conducted during Summer 2007), that the combined ambient... findings of EPA's Summer 2007 Technical System Audit of CARB's ambient air monitoring program). \\15\\ See, e... through www.regulations.gov or email. www.regulations.gov is an ``anonymous access'' system, and EPA will...

77 FR 31268 - Determination of Attainment for the Paul Spur/Douglas PM10

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... requirements under 40 CFR part 58.\\7\\ Furthermore, we concluded in our Technical System Audit Report concerning... www.regulations.gov or email. www.regulations.gov is an ``anonymous access'' system, and EPA will not...) in the nonattainment area, and entered into the EPA Air Quality System (AQS) database. Data from air...

76 FR 69786 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated: Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... available on June 20, 2011 in the Central Registration Depository system (``WebCRD''), which is operated by... the proposed rule change is available on the Exchange's Web site ( http://www.cboe.org/legal ), at the... on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the...

77 FR 50138 - Submission for OMB Review; Comment Request: Collection of Customer Service, Demographic, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

... chat service; using NCI's Contact Us page on www.cancer.gov ; and using NCI's Facebook page. CIS..., ethnicity, education, household income, number in household, and five questions about health care/coverage... responds to cancer-related inquiries to its Facebook page and its Contact Us form on www.cancer.gov but...

75 FR 57090 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NASDAQ OMX PHLX, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... website at http://www.nasdaqtrader.com/micro.aspx?id=PHLXRulefilings , at the principal office of the Exchange, on the Commission's website at http://www.sec.gov/ , and at the Commission's Public Reference... designed to promote just and equitable principles of trade, to remove impediments to and perfect the...

76 FR 32975 - Information Collection Available for Public Comments and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... Administrative Waiver of the Jones Act 46 U.S.C. 12121, 46 CFR 388. Expiration Date of Approval: Three years from... by electronic means via the Internet at http://www.regulations.gov/search/index.jsp . Specifically... the World Wide Web at http://www.regulations.gov/search/index.jsp . Privacy Act: Anyone is able to...

77 FR 14600 - Public Availability of the Department of Veterans Affairs Fiscal Year (FY) 2011 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... Procurement Policy (OFPP). OFPP's guidance is available at http:// www.whitehouse.gov/sites/default/files... a summary of the inventory on the VA Web site at: http://www.va.gov/oal/library/scaInventory.asp... to Marilyn Harris, Director, Procurement Policy and Warrant Management Service, in the Office of...

75 FR 58023 - Guidelines Establishing Test Procedures for the Analysis of Pollutants Under the Clean Water Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is an ``anonymous access... preceding FOR FURTHER INFORMATION CONTACT section. B. What should I consider as I prepare my comments for... VCSB: Voluntary Consensus Standards Body WET: Whole Effluent Toxicity Table of Contents I. Statutory...

77 FR 46911 - Approval and Promulgation of Air Quality Implementation Plans; Michigan; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

.... or until all parties present have had the opportunity to speak. EPA shall maintain a Web site at http... or otherwise protected through www.regulations.gov or email. The www.regulations.gov Web site is an... viruses. For additional instructions on submitting comments, go to Section I of the SUPPLEMENTARY...

78 FR 36716 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Philadelphia County...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... or otherwise protected through www.regulations.gov or email. The www.regulations.gov Web site is an.... Although listed in the index, some information is not publicly available, i.e., CBI or other information... Philadelphia County addressing the requirements of RACT under the 1997 8-hour ozone NAAQS. I. Background Ozone...

76 FR 64185 - Approval and Promulgation of Implementation Plans; Arkansas; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... existing man-made impairment of visibility in mandatory Class I areas caused by emissions of air pollutants... http://www.regulations.gov or e- mail. The http://www.regulations.gov Web site is an ``anonymous access.... Table of Contents I. Overview of Proposed Actions A. Regional Haze B. Interstate Transport and...

77 FR 22847 - National Emission Standards for Hazardous Air Pollutants for Polyvinyl Chloride and Copolymers...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

.... EPA-HQ-OAR-2002-0037. All documents in the docket are listed on the http://www.regulations.gov Web... voluntary consensus standards VOC volatile organic compound WWW World Wide Web Organization of This Document. The following outline is provided to aid in locating information in this preamble. I. General...

77 FR 11839 - Approval and Promulgation of Implementation Plans; Louisiana; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... prevent any future and remedy any existing man-made impairment of visibility in mandatory Class I areas... national goal of achieving natural visibility conditions in Class I areas. In a separate action, the EPA... to be CBI or otherwise protected through www.regulations.gov or email. The www.regulations.gov Web...

77 FR 47677 - Duke Energy Carolinas, LLC, McGuire Nuclear Station, Units 1 and 2, Notice of Consideration of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... Facility Operating License, Proposed No Significant Hazards Consideration Determination, and Opportunity... following methods: Federal Rulemaking Web site: Go to http://www.regulations.gov and search for Docket ID... related to this document by any of the following methods: Federal Rulemaking Web Site: Go to http://www...

75 FR 70962 - California Green Trade Corridor Transportation Investment Generating Economic Recovery (TIGER)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... Final EA and Finding of No Significant Impact can be obtained or viewed online at http:[sol][sol]www..., users need to obtain a free copy of Acrobat Reader. The Acrobat Reader can be obtained from http:[sol][sol]www.adobe.com/ prodindex/acrobat/readstep.html. By order of the Maritime Administrator. Dated...

76 FR 38340 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

...: http:[sol][sol]www.regulations.gov. Follow the on-line instructions. 2. E-mail: [email protected] docket without change and may be made available online at http:[sol][sol]www.regulations.gov, including... otherwise protected should be clearly identified as such and should not be submitted through http:[sol][sol...

76 FR 38591 - National Emission Standards for Hazardous Air Pollutants: Secondary Lead Smelting; Extension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... comments, identified by Docket ID No. EPA-HQ- OAR-2011-0344, by one of the following methods: http:[sol][sol]www.regulations.gov: Follow the on-line instructions for submitting comments. E-mail: a-and-r... and may be made available online at http:[sol][sol]www.regulations.gov, including any personal...

77 FR 35703 - Collection of Information Under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... the docket on the Internet at http:[sol][sol] www.regulations.gov . A copy of the ICR is available through the docket on the Internet at http:[sol][sol] www.regulations.gov . Additionally, copies are... be received by July 16, 2012. We will post all comments received, without change, to http:[sol][sol...

77 FR 15407 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

... reflects a competitive pricing structure designed to incent market participants to direct their order flow... OMX BX fee schedule at: http://www.nasdaqtrader.com/Trader.aspx?id=bx_pricing . \\15\\ See BATS BYX fee... rest of the trading session. See NASDAQ Rule 4758 and NASDAQ Pricing List at: http://www.nasdaqtrader...

76 FR 49401 - Universal Service-Intercarrier Compensation Transformation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-10

... comments. Federal Communications Commission's Web Site: http://fjallfoss.fcc.gov/ecfs2/ . Follow the... available on the Commission's Web site at http://www.fcc.gov . Pursuant to Sec. Sec. 1.415 and 1.419 of the... 12th Street, SW., Room CY-B402, Washington, DC 20554; Web site: http://www.bcpiweb.com ; phone: 1-800...

76 FR 38149 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... programs) (444220 Retail Nursery, Lawn, and Garden Supply stores, 424910 Agricultural chemicals merchant...- 2010-0723, to (1) EPA online using http://www.regulations.gov (our preferred method), or by mail to... this ICR under Docket ID No. EPA-HQ-OPP-2010-0723, which is available for online viewing at http//: www...

76 FR 45253 - Meeting of the Mid-Atlantic/Northeast Visibility Union Executive Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-28

... Contact: Kromeklia Bryant, Ozone Transport Commission (OTC), 444 North Capitol Street NW., Suite 638, Washington, DC 20001; (202) 508-3840; e-mail: [email protected] ; Web site: http://www.otcair.org/manevu... e-mail: [email protected] or via the MANE- VU Web site at http://www.otcair.org/manevu/ . Dated: July...

78 FR 73442 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; State Boards Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system... because the heads of Maryland Department of the Environment (MDE) and the Maryland Public Service... SIP Revision On August 14, 2013, the State of Maryland, through MDE, submitted a SIP revision ( 13-03B...

75 FR 59706 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

.... The proposed project would consist of the following: (1) Three new submersible Kaplan turbine... to 6,000 characters, without prior registration, using the eComment system at http://www.ferc.gov... printed on the ``eLibrary'' link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp...

75 FR 59707 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... Kaplan turbine/generator units with a total installed capacity of 2.5 megawatts, to be installed... to 6,000 characters, without prior registration, using the eComment system at http://www.ferc.gov... printed on the ``eLibrary'' link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp...

75 FR 38097 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

....jsp ), you may also file an electronic comment through that website. The Commission will consider all comments that regulations.gov forwards to it. You may also visit the FTC website at ( http://www.ftc.gov... will be available to the public on the FTC Website, to the extent practicable, at ( http://www.ftc.gov...

75 FR 3191 - Endangered and Threatened Species; Notice of Public Hearings on Proposed Critical Habitat...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... comments via the Federal eRulemaking Portal website at http://www.regulations.gov Mail: P.O. Box 21668... analysis, maps, status reviews, and other materials relating to the proposed critical habitat designation can be found on the NMFS Alaska Region website www.alaskafisheries.noaa.gov/ . Authority: 16 U.S.C...

78 FR 13855 - Notice of March 14 Advisory Committee on Voluntary Foreign Aid Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... members and USAID leadership, and an open Q&A. A draft agenda, room location, and additional information will be forthcoming on the ACVFA Web site at http://www.usaid.gov/who-we-are/organization/advisory... register online at http://www.usaid.gov/who-we-are/organization/advisory-committee/get-involved . FOR...

77 FR 59441 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

... is available on the Exchange's Web site at www.directedge.com , at the Exchange's principal office... dark pools for low-cost, low impact executions, which takes a greater amount of time to fill an order... on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the...

77 FR 59429 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

... is available on the Exchange's Web site at www.directedge.com , at the Exchange's principal office... dark pools for low-cost, low impact executions, which takes a greater amount of time to fill an order... Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the submission, all subsequent amendments...

77 FR 52741 - MDEpiNet 2012 Annual Meeting: The Medical Device Epidemiology Network as a Partnership for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

...) proposed partnership structure and governance; (3) MDEpiNet as a framework for medical device postmarket.... 1061, Rockville, MD 20852 or electronic comments to http://www.regulations.gov . It is only necessary... transcript is available, it will be accessible at http://www.regulations.gov . It may be viewed at the...

78 FR 80369 - Federal Acquisition Regulation; Service Contracts Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

...-and- materials, and labor-hour contracts and orders above the simplified acquisition threshold (SAT... thresholds established in FAR 4.1703 (e.g., above the SAT for cost-reimbursement, time-and-materials, and... reporting will be made at www.sam.gov (See section 3.10 of the SAM User Guide at https://www.sam.gov/sam/SAM...

77 FR 23539 - WTO Dispute Settlement Proceeding Regarding European Communities and Certain Member States...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... Organization (``WTO Agreement''). That request may be found at www.wto.org contained in a document designated....wto.org contained in a document designated as WT/DS316/23. Public Comment: Requirements for... available on the Web site of the World Trade Organization, www.wto.org . Comments open to public inspection...

78 FR 28292 - Announcement of the Priority Grant Competition For Immediate Release

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... area may be found at our Web site at: http://www.usip.org/grants-fellowships/priority-grant-competition... announced throughout the year. Please visit our Web site at: http://www.usip.org/grants-fellowships/priority..., (202) 429-3842 (phone), (202) 833-1018 (fax), (202) 457-1719 (TTY), Email: [email protected]org . FOR...

77 FR 33015 - WTO Dispute Settlement Proceeding Regarding India-Measures Concerning the Importation of Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

....org contained in a document designated as WT/DS430/2. USTR invites written comments from the public....wto.org contained in a document designated as WT/DS430/1. The United States and India held... Trade Organization, www.wto.org . Comments open to public inspection may be viewed on the www...

78 FR 79451 - Service Corporation International, and Stewart Enterprises, Inc.; Analysis of Agreement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

....commentworks.com/ftc/scistewartconsent by following the instructions on the web-based form. If you prefer to... Wide Web, at http://www.ftc.gov/os/actions.shtm . A paper copy can be obtained from the FTC Public... extent practicable, on the public Commission Web site, at http://www.ftc.gov/os/publiccomments.shtm . As...

76 FR 7871 - Collection of Information Under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2010-1020; OMB Control Number: 1625-0108... submissions, please use only one of the following means: (1) Online: (a) To Coast Guard docket at http://www... may submit your comments and material online (via http://www.regulations.gov ), by fax, mail, or hand...

78 FR 68832 - National Advisory Committee on Institutional Quality and Integrity (NACIQI)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... process for institutions of higher education under Title IV, of the HEA, together with recommendations for... System at: www.gpo.gov/fdsys . At this site you can view this document, as well as all other documents of... documents of the Department published in the Federal Register by using the article search feature at: www...

77 FR 25669 - Atlantic Highly Migratory Species; North and South Atlantic Swordfish Quotas and Management Measures

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... Submission: Submit all electronic public comments via the Federal e-Rulemaking Portal www.regulations.gov... the public record and will generally be posted for public viewing on www.regulations.gov without... three public hearings on this proposed rule on May 22, 23, 25, and 31, 2012. The public hearings will be...

77 FR 60000 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing and Order...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... recently amended Rule 971 to, among other things, add new subsection D, which requires the chief executive...: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or... Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml...

75 FR 26708 - ArborGen, LLC; Availability of an Environmental Assessment and Finding of No Significant Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

...-2817 before coming. Those documents are also available on the Internet at (http:// www.aphis.usda.gov... its programs is available on the Internet at ( http://www.aphis.usda.gov ). FOR FURTHER INFORMATION... Are Plant Pests or Which There Is Reason to Believe Are Plant Pests,'' regulate, among other things...

77 FR 4841 - BOX Options Exchange LLC; Notice of Filing of Application, as Amended, for Registration as a...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

..., 2012. \\2\\ Amendment No. 1, among other things, provides the unconsolidated financial statements for... Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or Send an email to rule-comments... on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the...

78 FR 41480 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... explained below. The Exchange recently filed a rule change, SR-C2-2013-013 to, among other things, amend the... the following methods: Electronic Comments Use the Commission's Internet comment form ( http://www.sec... one method. The Commission will post all comments on the Commission's Internet Web site ( http://www...

78 FR 76349 - Self-Regulatory Organizations; Topaz Exchange LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

... change is available on the Exchange's Internet Web site at http://www.ise.com , at the principal office... immediately effective rule filing that, among other things, amended its Schedule of Fees to permit the... following methods: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules...

76 FR 20750 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... on the Exchange's Internet Web site at http://www.directedge.com . \\3\\ A Member is any registered... strategy to the ROUD/ROUE routing strategies is Parallel D or Parallel 2D with the DRT (Dark routing... one method. The Commission will post all comments on the Commission's Internet Web site ( http://www...

77 FR 52769 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... proposed rule change is available on the Exchange's Web site at www.nyse.com , at the principal office of... internalizing broker-dealers and various forms of alternative trading systems, including dark pools and... method. The Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov...

77 FR 72423 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... on the Exchange's Web site at http://www.nsx.com , at the principal office of the Exchange, and at....\\5\\ Such Trading Centers may include execution venues known as ``dark pools.'' The order will not be... Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of the submission, all...

75 FR 33875 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... membership in the Exchange. The text of the proposed rule change is available at the Exchange's Web site at http://www.batstrading.com , on the Commission's Web site at http://www.sec.gov , at the principal... for its equity securities market with respect to Modified Destination Specific Orders routed to a dark...

75 FR 17985 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

....'' The text of the proposed rule change is available at the Exchange's Web site at http://www.batstrading.com , on the Commission's Web site at http://www.sec.gov , at the principal office of the Exchange... a ``Dark Scan'' order). Although the identity of the Alternative Trading Systems to which a Dark...

77 FR 3492 - Information Collection Request Sent to the Office of Management and Budget (OMB) for Approval...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-24

... (703) 358-2482 (telephone). You may review the ICR online at http://www.reginfo.gov . Follow the... and avoid confusion for applicants. The currently approved forms are available online at http://www.../Upland Game Hunt Application). FWS Form 3-2357 (Migratory Bird Hunt Application). FWS Form 3-2358...

75 FR 10248 - GB Energy Park, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

...-deep, 3-mile-long canal carrying flows diverted from Cottonwood Creek by an existing diversion... on the Commission's Web site ( http://www.ferc.gov/docs-filing/ferconline.asp ) under the ``eFiling...Library'' link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket...

75 FR 78236 - Lock+TM

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

...-foot-wide, 20-foot-deep excavated power canal; (2) a 55-foot-long, 65-foot-wide, 8-foot-deep excavated... 18 CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site http://www.ferc.gov/docs... Web site at http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket number (P-13743-000, 13753...

77 FR 12337 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... Web site ( http://www.cboe.org/legal ), at the Exchange's Office of the Secretary, and at the... the duplicative numbering contained in Rules 5.5 and 24.9 by re-numbering the provisions added in SR...: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or...

75 FR 16387 - Approval and Promulgation of Air Quality Implementation Plan: Kentucky; Approval Section 110(a)(1...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... the comment period is that EPA has learned that supplemental information relating to projected... viewed online at http://www.regulations.gov using docket ID No. EPA-R04-OAR- 2007-1186-0043. Thus, EPA is...://www.regulations.gov : Follow the on-line instructions for submitting comments. 2. E-mail: benjamin...

77 FR 77156 - Self-Regulatory Organizations; ICE Clear Credit LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... other things, that the rules of a clearing agency be designed to promote the prompt and accurate... the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ), or Send an email to... all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/sro.shtml ). Copies of...

77 FR 2991 - Gulf of Mexico (GOM), Outer Continental Shelf (OCS), Central Planning Area (CPA), Oil and Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... circumstances and information arising from, among other things, the Deepwater Horizon event. This Final... Supplemental EIS) is available at BOEM's Internet Web site at http://www.boem.gov/Environmental-Stewardship... visit BOEM's Internet Web site at http://www.gomr.boem.gov/homepg/regulate/environ/libraries.html . FOR...

21 CFR 822.7 - What should I do if I do not agree that postmarket surveillance is appropriate?

Code of Federal Regulations, 2013 CFR

2013-04-01

... Radiological Health's (CDRH's) Web site (http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDRH/CDRHOmbudsman/default.htm.). [67 FR 38887, June 6, 2002, as amended at 72 FR 17399, Apr. 9...

21 CFR 822.7 - What should I do if I do not agree that postmarket surveillance is appropriate?

Code of Federal Regulations, 2014 CFR

2014-04-01

... Radiological Health's (CDRH's) Web site (http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDRH/CDRHOmbudsman/default.htm.). [67 FR 38887, June 6, 2002, as amended at 72 FR 17399, Apr. 9...

76 FR 1889 - Risk-Based Capital Guidelines: Market Risk

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-11

... regulatory measurement methodologies; and increase transparency through enhanced disclosures. The proposal... banks \\1\\ entitled International Convergence of Capital Measurement and Capital Standards (1988 Capital... the internal models approach (see http://www.bis.org/press/p970918a.htm ). \\5\\ 61 FR 47358 (September...

The Impacts of Social Media on Citizen Security Behavior in Mexico

DTIC Science & Technology

2012-03-01

consumo -de-medios- digitales -2010. 72 Guillermo Perezbolde V, “Twitter en México 2011, slide 9 of 16,” Mente Digital Presentation, June 9, 2011, http...recent times.68 67 Millward Brown, “Estudio de Consumo de Medios Digitales en México 2010,” IAB...México, http://www.slideshare.net/iabmexico/estudio-de- consumo -de-medios- digitales -2010. 68 Ibid. 28 Figure 2.3. Devices Used to Connect to the

UNASUR and Its Future Impact on the Americas

DTIC Science & Technology

2009-03-24

Community, “La Comunidad Sudamericana de Naciones: Un proyecto político y un gran programa de desarrollo” , http://www.comunidadandina.org/prensa...articulos/ wagner_palestra2005.htm (accessed February 10, 2009). 19 Andean Community, “Declaración sobre la Convergencia de los Procesos de Integración en ...from the constitutive treaty. 28 Natasha Niebieskikwiat, “Por el veto uruguayo, aplazan la elección de Kirchner en Unasur”, Clarin, December 18, 2008

Lipopolysaccharide modulation of a CD14-like molecule on porcine alveolar macrophages

NASA Technical Reports Server (NTRS)

Kielian, T. L.; Ross, C. R.; McVey, D. S.; Chapes, S. K.; Blecha, F.; Spooner, B. S. (Principal Investigator)

1995-01-01

Cluster of differentiation antigen 14 (CD14) functions as a receptor for lipopolysaccharide (LPS) LPS-binding protein (LBP) complexes. Because LPS has varying effects on CD14 expression in vitro, we evaluated CD14 expression in response to LPS with a fully differentiated macrophage phenotype, the alveolar macrophage. By using flow microfluorometric analysis and a radioimmunoassay with an anti-human CD14 monoclonal antibody (My4) that cross-reacts with porcine CD14, we found that macrophages stimulated with LPS for 24 h exhibited a two- to fivefold increase in CD14-like antigen compared with unstimulated cells. At low concentrations of LPS, up-regulation of the CD14-like antigen was dependent on serum; at higher concentrations of LPS, serum was not required. In the absence of serum a 10-fold higher dose of LPS (10 ng/ml) was required to increase CD14-like expression. In addition, LPS-induced CD14-like up-regulation correlated with secretion of tumor necrosis factor-alpha, regardless of serum concentration. Blockade with My4 antibody significantly inhibited LPS-induced tumor necrosis factor-alpha secretion at 1 ng/ml of LPS. However, inhibition decreased as we increased the LPS concentration, suggesting the existence of CD14-independent pathways of macrophage activation in response to LPS. Alternatively, My4 may have a lower affinity for the porcine CD14 antigen than LPS, which may have only partially blocked the LPS-LBP binding site at high concentrations of LPS. Therefore, these data suggest that LPS activation of porcine alveolar macrophages for 24 h increased CD14-like receptor expression. The degree of CD14-like up-regulation was related to LPS concentration, however, activation did not require the presence of serum at high concentrations of LPS.

Turkey’s Soft Power Assets in Peacekeeping Operations

DTIC Science & Technology

2015-06-01

and the term Tu-kiu (Turk) was first used in sixth century A.D. to describe nomadic people who were stretching from China to Black Sea.145 Within...Support Operations.” 168 John C. K. Daly, “Afghanistan: The Turkish Advantage,” accessed on April 6, 2015. http://www.isn.ethz.ch/ Digital -Library...http://www.isn.ethz.ch/ Digital -Library/Articles/Detail/?id=53227&lng=en. Davutoğlu, Ahmet. “Turkey’s Zero-Problems Foreign Policy.” Accessed March 31

Télèmetre utilisant une diode laser à balayage continu en fréquence et un double interférométre

NASA Astrophysics Data System (ADS)

Hafidi, Abdeslam; Pfeiffer, Pierre; Meyrueis, Patrick

2018-04-01

This paper, "Télèmetre utilisant une diode laser à balayage continu en fréquence et un double interférométre," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

76 FR 76475 - Employment Network (EN) Report Card

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

... SOCIAL SECURITY ADMINISTRATION [Docket No. SSA-2011-0096] Employment Network (EN) Report Card... Work Consumer Employment Network Report Card. SUMMARY: We are soliciting the input of beneficiaries... revised EN Report Card. An EN is a private or public entity that participates in the Ticket to Work (TTW...

Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs.

PubMed

Gisslen, Tate; Hillman, Noah H; Musk, Gabrielle C; Kemp, Matthew W; Kramer, Boris W; Senthamaraikannan, Paranthaman; Newnham, John P; Jobe, Alan H; Kallapur, Suhas G

2014-02-01

Histologic chorioamnionitis, frequently associated with preterm births and adverse outcomes, results in prolonged exposure of preterm fetuses to infectious agents and pro-inflammatory mediators, such as LPS. Endotoxin tolerance-type effects were demonstrated in fetal sheep following repetitive systemic or intra-amniotic (i.a.) exposures to LPS, suggesting that i.a. LPS exposure would cause endotoxin tolerance to a postnatal systemic dose of LPS in preterm sheep. In this study, randomized pregnant ewes received either two i.a. injections of LPS or saline prior to preterm delivery. Following operative delivery, the lambs were treated with surfactant, ventilated, and randomized to receive either i.v. LPS or saline at 30  min of age. Physiologic variables and indicators of systemic and lung inflammation were measured. Intravenous LPS decreased blood neutrophils and platelets values following i.a. saline compared to that after i.a. LPS. Intra-amniotic LPS prevented blood pressure from decreasing following the i.v. LPS, but also caused an increased oxygen index. Intra-amniotic LPS did not cause endotoxin tolerance as assessed by cytokine expression in the liver, lung or plasma, but increased myeloperoxidase-positive cells in the lung. The different compartments of exposure to LPS (i.a. vs i.v.) are unique to the fetal to newborn transition. Intra-amniotic LPS incompletely tolerized fetal lambs to postnatal i.v. LPS.

Virtual planets atlas 1.0 freeware

NASA Astrophysics Data System (ADS)

Legrand, C.; Chevalley, P.

2015-10-01

Since 2002, we develop the "Virtual Moon Atlas -http://www.ap-i.net/avl/en/start" a freeware to help Moon observing and to improve interest for Moon in general public. VMA freeware has been downloaded near 900000 times all over the world and is or has been used by several professional organizations such as Kitt Peak Observatory, National Japan Observatory, Birkbeck College / University College London (K. Joy), BBC Sky at night, several French astronomy magazines and astronomy writers (P. Harrington, S. French...) . Recommended by ESA, registered as educational software by French ministry for education, it has also yet been presented at 2006 & 2007 LPSC and PCC2 in 2011 We have declined this freeware in a new tool with the same goals, but for the telluric planets and satellites, the "Virtual Planets Atlas (VPA / http://www.ap-i.net/avp/en/start") now in version 1.0.

75 FR 57458 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... viewing on the Internet at http://www.regulations.gov as they are received without change, including any... University (NDU) Student Data Files (October 1, 2008; 73 FR 57080). Changes: * * * * * System location..., international military and civilian fellow, contractor, and private industry students attached to the National...

77 FR 54464 - Eliminating the Prohibition Against General Solicitation and General Advertising in Rule 506 and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-05

... will post all comments on the Commission's Internet Web site ( http://www.sec.gov/rules/proposed.shtml..., Release No. 33-7233 (Oct. 6, 1995) [60 FR 53458] at Ex. 20; Use of Electronic Media, Release No. 33-7856...

75 FR 12252 - Conference Call Meeting of the Manufactured Housing Consensus Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5406-N-01] Conference Call Meeting of...'s Consensus Committee Administering Organization, the National Fire Protection Association (NFPA... Housing Consensus Committee and the Administering Organization. The link can be found at: http://www.nfpa...

78 FR 21915 - Mid-Atlantic Fishery Management Council (MAFMC); Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

...://www.mafmc.org . Council address: Mid-Atlantic Fishery Management Council, 800 North State Street.... Moore Ph.D., Executive Director, Mid-Atlantic Fishery Management Council, 800 N. State Street, Suite 201... Deputy Director, Office of Sustainable Fisheries, National Marine Fisheries Service. [FR Doc. 2013-08625...

76 FR 79760 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... posts all comments received without change to http://www.regulations.gov , including any personal... each applicant continues to meet the vision exemption requirements. These factors provide an adequate... Policy. [FR Doc. 2011-32710 Filed 12-21-11; 8:45 am] BILLING CODE 4910-EX-P ...

78 FR 57677 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

... posts all comments received without change to http://www.regulations.gov , including any personal... continues to meet the vision exemption requirements. These factors provide an adequate basis for predicting... Policy. [FR Doc. 2013-22775 Filed 9-18-13; 8:45 am] BILLING CODE 4910-EX-P ...

75 FR 61135 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... Business Innovative Research (SBIR) Organizations/Groups. CATEGORIES OF RECORDS IN THE SYSTEM: Information... title, by any of the following methods: * Federal Rulemaking Portal: http://www.regulations.gov . Follow...,'' dated February 8, 1996 (February 20, 1996; 61 FR 6427). Dated: September 29, 2010. Mitchell S. Bryman...

Neoadjuvant radiation in primary extremity liposarcoma: correlation of MRI features with histopathology.

PubMed

Wortman, Jeremy R; Tirumani, Sree Harsha; Tirumani, Harika; Shinagare, Atul B; Jagannathan, Jyothi P; Hornick, Jason L; Ramaiya, Nikhil H

2016-05-01

To evaluate MRI features of response of primary extremity liposarcoma (LPS) to neoadjuvant radiation therapy (RT) with histopathologic correlation. In this IRB-approved study including 125 patients with extremity LPS treated with neoadjuvant RT from 2000 to 2013, MRI of the primary tumour in 18 patients (5 pleomorphic LPS, 13 myxoid LPS) before and after RT were reviewed by two radiologists by consensus. Histopathology of the surgical specimens was reviewed by a pathologist with expertise in sarcomas. In the pleomorphic LPS cohort, 3/5 tumours increased in size; 3/5 decreased in enhancing component; and 3/5 increased in peritumoral oedema, intratumoral haemorrhage, and necrosis. In the myxoid LPS cohort, 12/13 tumours decreased in size, 8/13 decreased in enhancing component, and 5/13 increased in internal fat following RT. Histopathology showed ≥50% residual tumour in 1/5 pleomorphic LPS and 2/13 myxoid LPS. Hyalinization/necrosis of ≥75% was noted in 4/5 pleomorphic LPS and 11/13 myxoid LPS. Cytodifferentiation was noted in 1/5 pleomorphic and 9/13 myxoid LPS. While pleomorphic LPS showed an increase in size, peritumoral oedema, intratumoral haemorrhage, and necrosis on MRI following neoadjuvant RT, myxoid LPS showed a decrease in size and enhancement with an increase in internal fat. • Pleomorphic LPS commonly increase in size and necrosis on MRI following RT. • Myxoid LPS commonly decrease in size and enhancement on MRI following RT. • Myxoid LPS often increase in fatty component on MRI following RT.

75 FR 51705 - Airworthiness Directives; Airbus Model A300 B4-600 and A300 B4-600R Series Airplanes, Model A300...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... FR (frame) 58 is necessary to enable the aeroplane to reach the Extended Service Goal (ESG). The... may send comments by any of the following methods: Federal eRulemaking Portal: Go to http://www... reinforcement of the upper fuselage circumferential joint at FR (frame) 58 is necessary to enable the aeroplane...

Development of Core Data Set of the Officer Longitudinal Research Data Base

DTIC Science & Technology

1987-07-01

FR EQ U EN CI ES FR OM TH E OM F. J DA TA OM FF RE Q; IN FI LE...OC FR EQ ; n ~ > t-3 ctJ ~ 10 q ts:l z n t< n 0 q z t-3 (/) 0 I’Jj ~ t-3 > ts:l t’i ts:l ~ ts:l z t-3 (/) 0 1󈧏 )I ’t1 ’U tz j z 0 H X 0... FR EQ U EN CI ES FR OM TH E SO M F. I DA TA SO M FF RE Q; IN FI LE IN ; IN PU T SS N IB 4. TY R $C H A R2

Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes.

PubMed

Yang, Dong; Zheng, Xinchuan; Wang, Ning; Fan, Shijun; Yang, Yongjun; Lu, Yongling; Chen, Qian; Liu, Xin; Zheng, Jiang

2016-09-06

Free bacterial lipopolysaccharide (LPS) is generally removed from the bloodstream through hepatic uptake via TLR4, the LPS pattern recognition receptor, but mechanisms for internalization and clearance of conjugated LPS are less clear. Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4. In this study, KB accelerated blood clearance of LPS. KB also enhanced LPS distribution in the hepatic tissues of C57 BL/6 mice, along with LPS uptake in primary hepatocytes and HepG2 cells. By contrast, KB inhibited LPS internalization in Kupffer and RAW 264.7 cells. Loss of TLR4 did not affect LPS uptake into KB-treated hepatocytes. We also detected selective upregulation of the asialoglycoprotein receptor (ASGPR) upon KB treatment, and ASGPR colocalized with KB in cultured hepatocytes. Molecular docking showed that KB bound to ASGPR in a manner similar to GalNAc, a known ASGPR agonist. GalNAc dose-dependently reduced KB internalization, suggesting it competes with KB for ASGPR binding, and ASGPR knockdown also impaired LPS uptake into hepatocytes. Finally, while KB enhanced LPS uptake, it was protective against LPS-induced inflammation and hepatocyte injury. Our study provides a new mechanism for conjugated LPS hepatic uptake induced by the LPS neutralizer KB and mediated by membrane ASGPR binding.

75 FR 16222 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

... liability for system outages. The text of the proposed rule change is attached as Exhibit 5 to the 19b-4...: Electronic Comments Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or... method. The Commission will post all comments on the Commission's Internet Web site ( http://www.sec.gov...