3D postural balance with regard to gravity line: an evaluation in the transversal plane on 93 patients and 23 asymptomatic volunteers

PubMed Central

Obeid, Ibrahim; Aurouer, Nicolas; Hauger, Olivier; Vital, Jean-Marc; Dubousset, Jean; Skalli, Wafa

2009-01-01

Relevance of posture assessment has been reported in case of spine disorders. This study explores the interest in quantifying posture using 3D reconstruction from biplanar X-rays in free standing position and a force plate. 93 patients consulting for spine disorders were divided (‘3D deformity’, ‘sagittal imbalance’ and ‘mild deformity’) and compared with 23 asymptomatic volunteers. Registration of the gravity line (GL) in reconstruction yielded transversal position of the center of acoustic meati (CAM) T1, T4, T9, L3, S1 and hip axis (HA) with regard to GL. Transversal position of CAM and L3 appeared as relevant parameters to discriminate patients from volunteers. Sagittal inclination of the axis linking the CAM to HA was correlated with position of the CAM to GL (r = 0.92 for patients). In conclusion, observing posture in 3D with regard to GL provides clinical relevant information. CAM-HA inclination may improve postural evaluation without force plate. PMID:20035359

Use of multivitamin, acidifier and Azolla in the diet of broiler chickens

PubMed Central

Islam, M. A.; Nishibori, M.

2017-01-01

Objective The experiments were carried out to measure the effect of multivitamin, acidifier and Azolla on growth performance, profitability and lipid profiles of blood of broiler chickens to produce safe and cost effective broilers. Methods In experiment 1, 240 day-old Cobb-500 broiler chicks were fed diets; D1 (control), D2 (D1 with 1 mL multivitamin/liter water), D3 (D1 with 1 mL acidifier/liter water), D4 (D1 with 1 mL multivitamin and 2 mL acidifier/liter water) having 3 replications in each, and 20 chicks/replication. In experiment 2, 150 day-old Cobb-500 broiler chicks were fed diets; T1 (control), T2 (5% Azolla in the diet), T3 (7% Azolla in the diet) and T4 (T1 with 1 mL multivitamin and 1 mL acidifier/liter water) having 3 replications in each, and 20 chicks/replication in control, and 10 chicks/replication in the remaining dietary treatment groups for 35 days. Results In experiment 1, the highest live weight was observed in D4 (p<0.05), however, feed intake was statistically similar between diets (p>0.05). The lowest feed conversion ratio (FCR) (p<0.001) and mortality (p<0.05) were observed in D2 followed by D4, D1, and D3, respectively. There were no significant differences between diets for feed cost and net profit (p>0.05). However, evidently but not significantly, the highest net profit was obtained in D2 followed by D4, D1, and D3, respectively. In experiment 2, the highest live weight (p<0.05) and feed intake (p<0.001) were observed in T4. Mortality (p<0.01), FCR (p<0.01), feed cost (p<0.05) and net profit (p<0.05) were significantly different among diets. Considering net profit, T2 was the best performing dietary group followed by T3, T1, and T4, respectively. The lowest lipid profiles were observed in D3 followed by D1, D4, and D2, respectively (p<0.05). In experiment 2, the lowest total cholesterol, TG, and the highest amount of high density lipoprotein were observed in T2, followed by T3, T1, and T4, respectively (p<0.05). Evidently but not significantly, low density lipoprotein was the highest in T2 followed by T3, T4, and T1, respectively (p>0.05). Conclusion In conclusion, Azolla and acidifier reduced lipid profiles of broiler chickens. Considering net profit and lipid profiles, 5% Azolla may be the suitable dietary group for producing safe and profitable broilers. However, more studies are needed to confirm this study prior to suggesting using Azolla in the poultry industry. PMID:27507178

Soluble Model Fluids with Complete Scaling and Yang-Yang Features

NASA Astrophysics Data System (ADS)

Cerdeiriña, Claudio A.; Orkoulas, Gerassimos; Fisher, Michael E.

2016-01-01

Yang-Yang (YY) and singular diameter critical anomalies arise in exactly soluble compressible cell gas (CCG) models that obey complete scaling with pressure mixing. Thus, on the critical isochore ρ =ρc , C˜ μ≔-T d2μ /d T2 diverges as |t |-α when t ∝T -Tc→0- while ρd-ρc˜|t |2β where ρd(T )=1/2 [ρliq+ρgas] . When the discrete local CCG cell volumes fluctuate freely, the YY ratio Rμ=C˜μ/CV may take any value -∞ 0 . More general decorated CCGs, including "hydrogen bonding" water models, illuminate energy-volume coupling as relevant to Rμ.

Accuracy of Orthognathic Surgical Outcomes Using 2- and 3-Dimensional Landmarks-The Case for Apples and Oranges?

PubMed

Borba, Alexandre Meireles; José da Silva, Everton; Fernandes da Silva, André Luis; Han, Michael D; da Graça Naclério-Homem, Maria; Miloro, Michael

2018-01-12

To verify predicted versus obtained surgical movements in 2-dimensional (2D) and 3-dimensional (3D) measurements and compare the equivalence between these methods. A retrospective observational study of bimaxillary orthognathic surgeries was performed. Postoperative cone-beam computed tomographic (CBCT) scans were superimposed on preoperative scans and a lateral cephalometric radiograph was generated from each CBCT scan. After identification of the sella, nasion, and upper central incisor tip landmarks on 2D and 3D images, actual and planned movements were compared by cephalometric measurements. One-sample t test was used to statistically evaluate results, with expected mean discrepancy values ranging from 0 to 2 mm. Equivalence of 2D and 3D values was compared using paired t test. The final sample of 46 cases showed by 2D cephalometry that differences between actual and planned movements in the horizontal axis were statistically relevant for expected means of 0, 0.5, and 2 mm without relevance for expected means of 1 and 1.5 mm; vertical movements were statistically relevant for expected means of 0 and 0.5 mm without relevance for expected means of 1, 1.5, and 2 mm. For 3D cephalometry in the horizontal axis, there were statistically relevant differences for expected means of 0, 1.5, and 2 mm without relevance for expected means of 0.5 and 1 mm; vertical movements showed statistically relevant differences for expected means of 0, 0.5, 1.5 and 2 mm without relevance for the expected mean of 1 mm. Comparison of 2D and 3D values displayed statistical differences for the horizontal and vertical axes. Comparison of 2D and 3D surgical outcome assessments should be performed with caution because there seems to be a difference in acceptable levels of accuracy between these 2 methods of evaluation. Moreover, 3D accuracy studies should no longer rely on a 2-mm level of discrepancy but on a 1-mm level. Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Overview of Seismic Noise and it’s Relevance to Personnel Detection

DTIC Science & Technology

2008-04-01

production sites. Young et al. (1996) measured seismic noise with seismometers at the surface and within boreholes at three sites, and generated...ER D C/ CR R EL T R -0 8 -5 Overview of Seismic Noise and its Relevance to Personnel Detection Lindamae Peck April 2008 C ol d R...April 2008 Overview of Seismic Noise and its Relevance to Personnel Detection Lindamae Peck Cold Regions Research and Engineering Laboratory

Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, T.; Abazov, V. M.; Abbott, B.

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy ofmore » $$\\sqrt s =1.96$$ TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is $$A_{\\mathrm{FB}}^{t\\bar{t}} = 0.128 \\pm 0.025$$. As a result, the combined inclusive and differential asymmetries are consistent with recent standard model predictions.« less

Transport Simulations for Fast Ignition on NIF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strozzi, D J; Tabak, M; Grote, D P

2009-10-26

We are designing a full hydro-scale cone-guided, indirect-drive FI coupling experiment, for NIF, with the ARC-FIDO short-pulse laser. Current rad-hydro designs with limited fuel jetting into cone tip are not yet adequate for ignition. Designs are improving. Electron beam transport simulations (implicit-PIC LSP) show: (1) Magnetic fields and smaller angular spreads increase coupling to ignition-relevant 'hot spot' (20 um radius); (2) Plastic CD (for a warm target) produces somewhat better coupling than pure D (cryogenic target) due to enhanced resistive B fields; and (3) The optimal T{sub hot} for this target is {approx} 1 MeV; coupling falls by 3x asmore » T{sub hot} rises to 4 MeV.« less

Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

DOE PAGES

Aaltonen, T.; Abazov, V. M.; Abbott, B.; ...

2018-01-24

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy ofmore » $$\\sqrt s =1.96$$ TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is $$A_{\\mathrm{FB}}^{t\\bar{t}} = 0.128 \\pm 0.025$$. As a result, the combined inclusive and differential asymmetries are consistent with recent standard model predictions.« less

Evidence that logical reasoning depends on conscious processing.

PubMed

DeWall, C Nathan; Baumeister, Roy F; Masicampo, E J

2008-09-01

Humans, unlike other animals, are equipped with a powerful brain that permits conscious awareness and reflection. A growing trend in psychological science has questioned the benefits of consciousness, however. Testing a hypothesis advanced by [Lieberman, M. D., Gaunt, R., Gilbert, D. T., & Trope, Y. (2002). Reflection and reflexion: A social cognitive neuroscience approach to attributional inference. Advances in Experimental Social Psychology, 34, 199-249], four studies suggested that the conscious, reflective processing system is vital for logical reasoning. Substantial decrements in logical reasoning were found when a cognitive load manipulation preoccupied conscious processing, while hampering the nonconscious system with consciously suppressed thoughts failed to impair reasoning (Experiment 1). Nonconscious activation (priming) of the idea of logical reasoning increased the activation of logic-relevant concepts, but failed to improve logical reasoning performance (Experiments 2a-2c) unless the logical conclusions were largely intuitive and thus not reliant on logical reasoning (Experiment 3). Meanwhile, stimulating the conscious goal of reasoning well led to improvements in reasoning performance (Experiment 4). These findings offer evidence that logical reasoning is aided by the conscious, reflective processing system.

Blood flow quantification using 1D CFD parameter identification

NASA Astrophysics Data System (ADS)

Brosig, Richard; Kowarschik, Markus; Maday, Peter; Katouzian, Amin; Demirci, Stefanie; Navab, Nassir

2014-03-01

Patient-specific measurements of cerebral blood flow provide valuable diagnostic information concerning cerebrovascular diseases rather than visually driven qualitative evaluation. In this paper, we present a quantitative method to estimate blood flow parameters with high temporal resolution from digital subtraction angiography (DSA) image sequences. Using a 3D DSA dataset and a 2D+t DSA sequence, the proposed algorithm employs a 1D Computational Fluid Dynamics (CFD) model for estimation of time-dependent flow values along a cerebral vessel, combined with an additional Advection Diffusion Equation (ADE) for contrast agent propagation. The CFD system, followed by the ADE, is solved with a finite volume approximation, which ensures the conservation of mass. Instead of defining a new imaging protocol to obtain relevant data, our cost function optimizes the bolus arrival time (BAT) of the contrast agent in 2D+t DSA sequences. The visual determination of BAT is common clinical practice and can be easily derived from and be compared to values, generated by a 1D-CFD simulation. Using this strategy, we ensure that our proposed method fits best to clinical practice and does not require any changes to the medical work flow. Synthetic experiments show that the recovered flow estimates match the ground truth values with less than 12% error in the mean flow rates.

Spectroscopic Factors from the Single Neutron Pickup ^64Zn(d,t)

NASA Astrophysics Data System (ADS)

Leach, Kyle; Garrett, P. E.; Demand, G. A.; Finlay, P.; Green, K. L.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wong, J.; Towner, I. S.; Ball, G. C.; Faestermann, T.; Krücken, R.; Hertenberger, R.; Wirth, H.-F.

2010-11-01

A great deal of attention has recently been paid towards high-precision superallowed β-decay Ft values. With the availability of extremely high-precision (<0.1%) experimental data, precision on the individual Ft values are now dominated by the ˜1% theoretical corrections. This limitation is most evident in heavier superallowed nuclei (e.g. ^62Ga) where the isospin-symmetry-breaking (ISB) correction calculations become more difficult due to the truncated model space. Experimental spectroscopic factors for these nuclei are important for the identification of the relevant orbitals that should be included in the model space of the calculations. Motivated by this need, the single-nucleon transfer reaction ^64Zn(d,t)^63Zn was conducted at the Maier-Leibnitz-Laboratory (MLL) of TUM/LMU in Munich, Germany, using a 22 MeV polarized deuteron beam from the tandem Van de Graaff accelerator and the TUM/LMU Q3D magnetic spectrograph, with angular distributions from 10^o to 60^o. Results from this experiment will be presented and implications for calculations of ISB corrections in the superallowed ° decay of ^62Ga will be discussed.

Software Acquisition Management Practical Experience

DTIC Science & Technology

2009-04-23

t a comp ete m ss on so tware su te n ar Air Force Air Mobility Command declared Initial Operation ...or revised controls areR i t t i f d t l t t ll d d di i li d 43 necessary equ remen s managemen s un amen a o a con ro e an sc p ne...Warner Robins, GA 31088 FAA NAS Plan (TDWR) SOW S ft d l t t d i i t b d t do ware eve opmen managemen an eng neer ng o e con uc e in

Shock Testing the SEAWOLF Submarine, Final Environmental Impact Statement

DTIC Science & Technology

1998-05-01

relevant experience. Phil Barfield. Operational requirements. B.S. Mechanical Engineering. 14 years relevant experience. James Craig . Appendix D. B.S...Atlantic Biodiversity Center Nassau, Delaware Russell DeConti Center for Coastal Studies Provincetown, Massachusetts Robert Deegan Sierra Club...either area. C-9 APPENDIX D PHYSICAL IMPACTS OF EXPLOSIONS ON MARINE MAMMALS AND TURTLES James C. Craig Christian W. Hearn Naval Surface Warfare

Sensitivity of fields generated within magnetically shielded volumes to changes in magnetic permeability

NASA Astrophysics Data System (ADS)

Andalib, T.; Martin, J. W.; Bidinosti, C. P.; Mammei, R. R.; Jamieson, B.; Lang, M.; Kikawa, T.

2017-09-01

Future experiments seeking to measure the neutron electric dipole moment (nEDM) require stable and homogeneous magnetic fields. Normally these experiments use a coil internal to a passively magnetically shielded volume to generate the magnetic field. The stability of the magnetic field generated by the coil within the magnetically shielded volume may be influenced by a number of factors. The factor studied here is the dependence of the internally generated field on the magnetic permeability μ of the shield material. We provide measurements of the temperature-dependence of the permeability of the material used in a set of prototype magnetic shields, using experimental parameters nearer to those of nEDM experiments than previously reported in the literature. Our measurements imply a range of 1/μ dμ/dT from 0-2.7%/K. Assuming typical nEDM experiment coil and shield parameters gives μ/B0 dB0/dμ = 0.01, resulting in a temperature dependence of the magnetic field in a typical nEDM experiment of dB0/dT = 0 - 270 pT/K for B0 = 1 μT. The results are useful for estimating the necessary level of temperature control in nEDM experiments.

Exploring nuclear reactions relevant to Stellar and Big-Bang Nucleosynthesis using High-Energy-Density plasmas at OMEGA and the NIF

NASA Astrophysics Data System (ADS)

Gatu Johnson, M.

2017-10-01

Thermonuclear reaction rates and nuclear processes have been explored traditionally by means of accelerator experiments, which are difficult to execute at conditions relevant to Stellar Nucleosynthesis (SN) and Big Bang Nucleosynthesis (BBN). High-Energy-Density (HED) plasmas closely mimic astrophysical environments and are an excellent complement to accelerator experiments in exploring SN and BBN-relevant nuclear reactions. To date, our work using HED plasmas at OMEGA and NIF has focused on the complementary 3He+3He, T+3He and T +T reactions. First studies of the T +T reaction indicated the significance of the 5He ground-state resonance in the T +T neutron spectrum. Subsequent T +T experiments showed that the strength of this resonance varies with center-of-mass (c-m) energy in the range of 16-50 keV, a variation that is not fundamentally understood. Studies of the 3He+3He and T+3He reactions have also been conducted at OMEGA at c-m energies of 165 keV and 80 keV, respectively, and the results revealed three things. First, a large cross section for the T+3He- γ branch can be ruled out as an explanation for the anomalously high abundance of 6Li in primordial material. Second, the results contrasted to theoretical modeling indicate that the mirror-symmetry assumption is not enough to capture the differences between T +T and 3He+3He reactions. Third, the elliptical spectrum assumed in the analysis of 3He+3He data obtained in accelerator experiments is incorrect. Preliminary data from recent experiments at the NIF exploring the 3He+3He reaction at c-m energies of 60 keV and 100 keV also indicate that the underlying physics changes with c-m energy. In this talk, we describe these findings and future directions for exploring light-ion reactions at OMEGA and the NIF. The work was supported in part by the US DOE, LLE, and LLNL.

Dependence of Exciton Diffusion Length and Diffusion Coefficient on Photophysical Parameters in Bulk Heterojunction Organic Solar Cells

NASA Astrophysics Data System (ADS)

Yeboah, Douglas; Singh, Jai

2017-11-01

Recently, the dependence of exciton diffusion length (LD ) on some photophysical parameters of organic solids has been experimentally demonstrated, however no systematic theoretical analysis of this phenomenon has been carried out. We have conducted a theoretical study by using the Förster resonance energy transfer and Dexter carrier transfer mechanisms together with the Einstein-Smoluchowski diffusion equation to derive analytical models for the diffusion lengths (LD ) and diffusion coefficients (D) of singlet (S) and triplet (T) excitons in organic solids as functions of spectral overlap integral (J) , photoluminescence (PL) quantum yield (φD ) , dipole moment (μT ) and refractive index (n) of the photoactive material. The exciton diffusion lengths and diffusion coefficients in some selected organic solids were calculated, and we found that the singlet exciton diffusion length (LDS ) increases with φD and J, and decreases with n. Also, the triplet exciton diffusion length (LDT ) increases with φD and decreases with μT . These may be achieved through doping the organic solids into broad optical energy gap host materials as observed in previous experiments. The calculated exciton diffusion lengths are compared with experimental values and a reasonably good agreement is found between them. The results presented are expected to provide insight relevant to the synthesis of new organic solids for fabrication of bulk heterojunction organic solar cells characterized by better power conversion efficiency.

Generation and Transport of Hot Electrons in Cone-Wire Targets

NASA Astrophysics Data System (ADS)

Beg, Farhat

2009-11-01

We present results from a series of experiments where cone-wire targets in various configurations were employed both to assess hot electron coupling efficiency, and to reveal the source temperature of the hot electrons. Initial experiments were performed on the Vulcan petawatt laser at the Rutherford Appleton Laboratory and Titan laser at the Lawrence Livermore National Laboratory. Results with aluminum cones joined to Cu wires of diameters from 10 to 40 μm show that the laser coupling efficiency to electron energy within the wire is proportional to the cross sectional area of the wire. In addition, coupling into the wire was observed to decrease with the laser prepulse and cone-wall thickness. More recently, this study was extended, using the OMEGA EP laser. The resulting changes in coupling energy give indications of the scaling as we approach FI-relevant conditions. Requirements for FI scale fast ignition cone parameters: tip thickness, wall thickness, laser prepulse and laser pulse length, will be discussed. In collaboration with T. Yabuuchi, T. Ma, D. Higginson, H. Sawada, J. King, M.H. Key, K.U. Akli, Al Elsholz, D. Batani, H. Chen, R.R. Freeman, L. Gizzi, J. Green, S. Hatchett, D. Hey, P. Jaanimagi, J. Koch, K. L. Lancaster, D.Larson, A.J. MacKinnon, H. McLean, A. MacPhee, P.A. Norreys, P.K Patel, R. B. Stephens, W. Theobald, R. Town, M. Wei, S. Wilks, Roger Van Maren, B. Westover and L. VanWoerkom.

Butanol fraction of Parkia biglobosa (Jacq.) G. Don leaves enhance pancreatic β-cell functions, stimulates insulin secretion and ameliorates other type 2 diabetes-associated complications in rats.

PubMed

Ibrahim, Mohammed Auwal; Habila, James Dama; Koorbanally, Neil Anthony; Islam, Md Shahidul

2016-05-13

Ethnopharmacological surveys have reported that Parkia biglobosa (Jacq.) G. Don (Leguminosae) is among the plants commonly used in the traditional management of diabetes mellitus in Nigeria and Togo. This study investigated the anti-diabetic activity of the butanol fraction of P. biglobosa leaves (PBBF) in a type 2 diabetes (T2D) model of rats and a possible bioactive compound in the fraction. T2D was induced by feeding rats with a 10% fructose solution ad libitum for two weeks followed by an intraperitoneal injection of 40mg/kg body weight streptozotocin and the animals were orally treated with 150 and 300mg/kg BW of the PBBF for five days in a week. Another group of rats was non-diabetic but similarly administered with 300mg/kg BW of the PBBF. Food and fluid intakes, body weight changes and blood glucose levels were monitored during the experiment while other relevant diabetes-associated parameters were measured at the end of the experiment. The PBBF treatments significantly (P<0.05) decreased the blood glucose levels and improved the glucose tolerance ability compared to untreated diabetic rats. Furthermore, the treatments were found to improve pancreatic β cell function (HOMA-β), stimulate insulin secretions, decrease insulin resistance (HOMA-IR), restore liver glycogen, ameliorate serum dyslipidaemia and prevent hepatic and renal damages compared to untreated diabetic rats. Phytochemical analysis of the fraction led to the isolation of lupeol which inhibited α-glucosidase and α-amylase in non-competitive and uncompetitive inhibition patterns respectively. It was concluded that PBBF possessed remarkable anti-T2D activity which is mediated through modulation of β-cell function and stimulation of insulin secretion and the lower dose (150mg/kg BW) was found optimum for anti-T2D activity compared to the high dose (300mg/kg BW) in this study. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Search for space charge effects in the ICARUS T600 LAr-TPC

NASA Astrophysics Data System (ADS)

Torti, Marta

2016-11-01

Space charge in Liquid Argon Time Projection Chamber is due to the accumu- lation of positive ions, produced by ionizing tracks crossing the detector, which slowly flow toward the cathode. As a consequence, electric field distortions may arise, thus hindering the possibility to produce faithful 3D images of the ionizing events. The presence of space charge becomes relevant for large TPCs operating at surface or at shallow depths, where cosmic ray flux is high. These effects could interest the next phase of the ICARUS T600 detector, which will be deployed at shallow depths as a Far Detector for Short Baseline Neutrino experiment at FNAL dedicated to sterile neutrino searches. In 2001, the first ICARUS T600 module (T300) operated at surface in Pavia (Italy), recording cosmic ray data. In this work, a sample of cosmic muon tracks from the 2001 run was analyzed and results on space charge effects in LAr-TPCs are shown.

Grapheme-color synesthetes show peculiarities in their emotional brain: cortical and subcortical evidence from VBM analysis of 3D-T1 and DTI data.

PubMed

Melero, Helena; Peña-Melián, Ángel; Ríos-Lago, Marcos; Pajares, Gonzalo; Hernández-Tamames, Juan Antonio; Álvarez-Linera, Juan

2013-06-01

Grapheme-color synesthesia is a neurological phenomenon in which viewing achromatic letters/numbers leads to automatic and involuntary color experiences. In this study, voxel-based morphometry analyses were performed on T1 images and fractional anisotropy measures to examine the whole brain in associator grapheme-color synesthetes. These analyses provide new evidence of variations in emotional areas (both at the cortical and subcortical levels), findings that help understand the emotional component as a relevant aspect of the synesthetic experience. Additionally, this study replicates previous findings in the left intraparietal sulcus and, for the first time, reports the existence of anatomical differences in subcortical gray nuclei of developmental grapheme-color synesthetes, providing a link between acquired and developmental synesthesia. This empirical evidence, which goes beyond modality-specific areas, could lead to a better understanding of grapheme-color synesthesia as well as of other modalities of the phenomenon.

Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability.

PubMed Central

Seela, F; Wei, C; Melenewski, A

1996-01-01

The self-aggregation of the oligonucleotide d(T4isoG4T4) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified. This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T4G4T4) (2). The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T4isoG4T4)]4 is more stable than that of [d(T4G4T4)]4. A mixture of d(T4isoG4T4) and d(T4G4T4) forms mixed tetraplexes containing strands of d(T4isoG4T4) and d(T4G4T4). PMID:9016664

THM and primordial nucleosynthesis: Results and perspectives

NASA Astrophysics Data System (ADS)

Pizzone, R. G.; Spartá, R.; Bertulani, C.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Tumino, A.

2017-09-01

Big Bang Nucleosynthesis (BBN) requires several nuclear physics inputs and nuclear reaction rates. An up-to-date compilation of direct cross sections of d(d,p)t, d(d,n) 3 He and 3 He(d,p) 4 He reactions is given, being these ones among the most uncertain bare-nucleus cross sections. An intense experimental effort has been carried on in the last decade to apply the Trojan Horse Method (THM) to study reactions of relevance for the BBN and measure their astrophysical S( E) -factor. The reaction rates and the relative error for the four reactions of interest are then numerically calculated in the temperature ranges of relevance for BBN ( 0.01

Understanding the Subjective Experience of Medication Adherence for Older Urban African Americans With Type 2 Diabetes and a History of Illicit Drug Addiction.

PubMed

Wallace, Brandy Harris; Reese, Ashante M; Chard, Sarah; Roth, Erin G; Quinn, Charlene; Eckert, J Kevin

2017-04-01

African Americans experience high rates of type 2 diabetes mellitus (T2D). Self-management strategies, such as medication adherence, are key to mitigating negative T2D outcomes. This article addresses a gap in the literature by examining the intersections of drug abuse histories and medication adherence among urban, older African Americans with T2D. In-depth interview data were collected as part of a larger ethnographic study examining the subjective experience of T2D among urban older adults. Two representative focal cases were selected and thematic analysis performed to illustrate how former illicit drug addicts perceive prescription medication usage. Narratives reveal that participants are displeased about having to take prescription drugs and are making lifestyle changes to reduce medication usage and maintain sobriety. Previous drug abuse not only complicates medication adherence but is also a significant part of how older African Americans who are former drug users frame their understanding of T2D more broadly.

Serum cystatin C in youth with diabetes: The SEARCH for diabetes in youth study.

PubMed

Kanakatti Shankar, Roopa; Dolan, Lawrence M; Isom, Scott; Saydah, Sharon; Maahs, David M; Dabelea, Dana; Reynolds, Kristi; Hirsch, Irl B; Rodriguez, Beatriz L; Mayer-Davis, Elizabeth J; Marcovina, Santica; D'Agostino, Ralph; Mauer, Michael; Mottl, Amy K

2017-08-01

We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D). Youth (ages 12-19years) without diabetes (N=544) were ascertained from the NHANES Study 2000-2002 and those with T1D (N=977) and T2D (N=168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI. Adjusted cystatin C concentrations were statistically higher in NHANES (0.85mg/L) than in either the T1D (0.75mg/L) or T2D (0.70mg/L) SEARCH groups (P<0.0001). Fasting glucose was inversely related to cystatin C only in T1D (P<0.001) and BMI positively associated only in T2D (P<0.01) while HbA1c was inversely associated in both groups. Cystatin C concentrations are statistically higher in youth without diabetes compared to T1D or T2D, however the clinical relevance of this difference is quite small, especially in T1D. In youth with diabetes, cystatin C varies with BMI and acute and chronic glycemic control, however their effects may be different according to diabetes type. Copyright © 2017 Elsevier B.V. All rights reserved.

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society.

PubMed

Mallone, R; Mannering, S I; Brooks-Worrell, B M; Durinovic-Belló, I; Cilio, C M; Wong, F S; Schloot, N C

2011-01-01

Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays are being developed for these purposes, it is important to optimize and standardize methods for processing human blood samples for these assays. To this end, we review data relevant to critical parameters in peripheral blood mononuclear cell (PBMC) isolation, (cryo)preservation, distribution and usage for detecting antigen-specific T cell responses. Based on these data, we propose recommendations on processing blood samples for T cell assays and identify gaps in knowledge that need to be addressed. These recommendations may be relevant not only for the analysis of T cell responses in autoimmune disease, but also in cancer and infectious disease, particularly in the context of clinical trials. © 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.

Patient perspectives on peer mentoring: type 1 diabetes management in adolescents and young adults.

PubMed

Lu, Yang; Pyatak, Elizabeth A; Peters, Anne L; Wood, Jamie R; Kipke, Michele; Cohen, Marisa; Sequeira, Paola A

2015-02-01

The purpose of the study was to identify attitudes and topics relevant to peer mentoring as an adherence-promoting intervention for adolescents and young adults (YAs) with type 1 diabetes (T1D). Self-administered survey data were collected in 2 diabetes clinics from a convenience sample of adolescents as prospective mentees (ages 13-18) and YAs as prospective mentors (ages 19-25) with T1D. Survey topics included demographics, disease history, glycemic control, adherence, depression, barriers to disease management, social support, and interest in peer mentoring. Descriptive statistical analyses, thematic coding, and stepwise multivariate logistic regression were performed. A majority of the 54 adolescents and 46 YAs expressed interest in a peer mentoring program. Having supportive friends and living in a large household positively predicted adolescent interest in having a peer mentor. Approximately one-third of all participants experienced social barriers to diabetes management. For adolescents, barriers included inflexible schedules, unfamiliar foods, and the embarrassment of checking blood glucose in front of others. Young adults reported barriers in tracking food consumption and remembering to check blood glucose. Various diabetes management skills were in high demand by adolescents, who especially desired to learn about managing T1D on their own and in college. Participants were open to multiple communication modes, including in-person meetings, phone, text messaging, and social media. Many adolescents and young adults with T1D are interested in peer mentoring as a way to facilitate learning and sharing essential diabetes management skills and experiences. © 2014 The Author(s).

Patient Perspectives on Peer Mentoring: Type 1 Diabetes Management in Adolescents and Young Adults

PubMed Central

Lu, Yang; Pyatak, Elizabeth A.; Peters, Anne L.; Wood, Jamie R.; Kipke, Michele; Cohen, Marisa; Sequeira, Paola A.

2014-01-01

Purpose The purpose of the study was to identify attitudes and topics relevant to peer mentoring as an adherence-promoting intervention for adolescents and young adults (YAs) with type 1 diabetes (T1D). Methods Self-administered survey data were collected in two diabetes clinics from a convenience sample of adolescents as prospective mentees (ages 13–18) and YAs as prospective mentors (ages 19–25) with T1D. Survey topics included demographics, disease history, glycemic control, adherence, depression, barriers to disease management, social support, and interest in peer mentoring. Descriptive statistical analyses, thematic coding, and stepwise multivariate logistic regression were performed. Results A majority of the 54 adolescents and 46 YAs expressed interest in a peer mentoring program. Having supportive friends and living in a large household positively predicted adolescent interest in having a peer mentor. Approximately one third of all participants experienced social barriers to diabetes management. For adolescents, barriers included inflexible schedules, unfamiliar foods, and the embarrassment of checking blood glucose in front of others. Young adults reported barriers in tracking food consumption and remembering to check blood glucose. Various diabetes management skills were in high demand by adolescents, who especially desired to learn about managing T1D on their own and in college. Participants were open to multiple communication modes, including in-person meetings, phone, text messaging, and social media. Conclusions Many adolescents and young adults with T1D are interested in peer mentoring as a way to facilitate learning and sharing essential diabetes management skills and experiences. PMID:25394732

Memory and visual search in naturalistic 2D and 3D environments

PubMed Central

Li, Chia-Ling; Aivar, M. Pilar; Kit, Dmitry M.; Tong, Matthew H.; Hayhoe, Mary M.

2016-01-01

The role of memory in guiding attention allocation in daily behaviors is not well understood. In experiments with two-dimensional (2D) images, there is mixed evidence about the importance of memory. Because the stimulus context in laboratory experiments and daily behaviors differs extensively, we investigated the role of memory in visual search, in both two-dimensional (2D) and three-dimensional (3D) environments. A 3D immersive virtual apartment composed of two rooms was created, and a parallel 2D visual search experiment composed of snapshots from the 3D environment was developed. Eye movements were tracked in both experiments. Repeated searches for geometric objects were performed to assess the role of spatial memory. Subsequently, subjects searched for realistic context objects to test for incidental learning. Our results show that subjects learned the room-target associations in 3D but less so in 2D. Gaze was increasingly restricted to relevant regions of the room with experience in both settings. Search for local contextual objects, however, was not facilitated by early experience. Incidental fixations to context objects do not necessarily benefit search performance. Together, these results demonstrate that memory for global aspects of the environment guides search by restricting allocation of attention to likely regions, whereas task relevance determines what is learned from the active search experience. Behaviors in 2D and 3D environments are comparable, although there is greater use of memory in 3D. PMID:27299769

RESEARCH BULLETIN. NUMBER 3.

ERIC Educational Resources Information Center

American Foundation for the Blind, New York, NY.

RESEARCH STUDIES RELEVANT TO SOME ASPECT OF VISUAL IMPAIRMENT ARE CONTAINED IN THE BULLETIN. D.M. BAUMANN AND OTHERS REPORT ON THE COLLAPSIBLE CAN, AND T.L. DEFAZIO AND T.B. SHERIDAN ANALYZE THE VIBRATIONS OF THE CANE. J.J. GIBSON CONSIDERS SENSITIVITY, AND J. MICKUNAS, JR., AND T.B. SHERIDAN DISCUSS THE OBSTACLE COURSE IN MOBILITY EVALUATION OF…

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study.

PubMed

Gan, Wei; Clarke, Robert J; Mahajan, Anubha; Kulohoma, Benard; Kitajima, Hidetoshi; Robertson, Neil R; Rayner, N William; Walters, Robin G; Holmes, Michael V; Chen, Zhengming; McCarthy, Mark I

2017-01-01

Background: Observational studies have demonstrated that increased bone mineral density is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of coronary heart disease (CHD) is less clear. Moreover, substantial uncertainty remains about the causal relevance of increased bone mineral density for T2D and CHD, which can be assessed by Mendelian randomisation studies.  Methods: We identified 235 independent single nucleotide polymorphisms (SNPs) associated at p <5×10 -8 with estimated heel bone mineral density (eBMD) in 116,501 individuals from the UK Biobank study, accounting for 13.9% of eBMD variance. For each eBMD-associated SNP, we extracted effect estimates from the largest available GWAS studies for T2D (DIAGRAM: n=26,676 T2D cases and 132,532 controls) and CHD (CARDIoGRAMplusC4D: n=60,801 CHD cases and 123,504 controls). A two-sample design using several Mendelian randomization approaches was used to investigate the causal relevance of eBMD for risk of T2D and CHD. In addition, we explored the relationship of eBMD, instrumented by the 235 SNPs, on 12 cardiovascular and metabolic risk factors. Finally, we conducted Mendelian randomization analysis in the reverse direction to investigate reverse causality. Results: Each one standard deviation increase in genetically instrumented eBMD (equivalent to 0.14 g/cm 2 ) was associated with an 8% higher risk of T2D (odds ratio [OR] 1.08; 95% confidence interval [CI]: 1.02 to 1.14; p =0.012) and 5% higher risk of CHD (OR 1.05; 95%CI: 1.00 to 1.10; p =0.034). Consistent results were obtained in sensitivity analyses using several different Mendelian randomization approaches. Equivalent increases in eBMD were also associated with lower plasma levels of HDL-cholesterol and increased insulin resistance. Mendelian randomization in the reverse direction using 94 T2D SNPs or 52 CHD SNPs showed no evidence of reverse causality with eBMD. Conclusions: These findings suggest a causal relationship between elevated bone mineral density with risks of both T2D and CHD.

Magnetic Resonance Fingerprinting with short relaxation intervals.

PubMed

Amthor, Thomas; Doneva, Mariya; Koken, Peter; Sommer, Karsten; Meineke, Jakob; Börnert, Peter

2017-09-01

The aim of this study was to investigate a technique for improving the performance of Magnetic Resonance Fingerprinting (MRF) in repetitive sampling schemes, in particular for 3D MRF acquisition, by shortening relaxation intervals between MRF pulse train repetitions. A calculation method for MRF dictionaries adapted to short relaxation intervals and non-relaxed initial spin states is presented, based on the concept of stationary fingerprints. The method is applicable to many different k-space sampling schemes in 2D and 3D. For accuracy analysis, T 1 and T 2 values of a phantom are determined by single-slice Cartesian MRF for different relaxation intervals and are compared with quantitative reference measurements. The relevance of slice profile effects is also investigated in this case. To further illustrate the capabilities of the method, an application to in-vivo spiral 3D MRF measurements is demonstrated. The proposed computation method enables accurate parameter estimation even for the shortest relaxation intervals, as investigated for different sampling patterns in 2D and 3D. In 2D Cartesian measurements, we achieved a scan acceleration of more than a factor of two, while maintaining acceptable accuracy: The largest T 1 values of a sample set deviated from their reference values by 0.3% (longest relaxation interval) and 2.4% (shortest relaxation interval). The largest T 2 values showed systematic deviations of up to 10% for all relaxation intervals, which is discussed. The influence of slice profile effects for multislice acquisition is shown to become increasingly relevant for short relaxation intervals. In 3D spiral measurements, a scan time reduction of 36% was achieved, maintaining the quality of in-vivo T1 and T2 maps. Reducing the relaxation interval between MRF sequence repetitions using stationary fingerprint dictionaries is a feasible method to improve the scan efficiency of MRF sequences. The method enables fast implementations of 3D spatially resolved MRF. Copyright © 2017 Elsevier Inc. All rights reserved.

Entropy Production and Non-Equilibrium Steady States

NASA Astrophysics Data System (ADS)

Suzuki, Masuo

2013-01-01

The long-term issue of entropy production in transport phenomena is solved by separating the symmetry of the non-equilibrium density matrix ρ(t) in the von Neumann equation, as ρ(t) = ρs(t) + ρa(t) with the symmetric part ρs(t) and antisymmetric part ρa(t). The irreversible entropy production (dS/dt)irr is given in M. Suzuki, Physica A 390(2011)1904 by (dS/dt)irr = Tr( {H}(dρ s{(t)/dt))}/T for the Hamiltonian {H} of the relevant system. The general formulation of the extended von Neumann equation with energy supply and heat extraction is reviewed from the author's paper (M. S.,Physica A391(2012)1074). irreversibility; entropy production; transport phenomena; electric conduction; thermal conduction; linear response; Kubo formula; steady state; non-equilibrium density matrix; energy supply; symmetry-separated von Neumann equation; unboundedness.

High-temperature shock tube and modeling studies on the reactions of methanol with D-atoms and CH3-radicals.

PubMed

Peukert, S L; Michael, J V

2013-10-10

The shock tube technique has been used to study the hydrogen abstraction reactions D + CH3OH → CH2O + H + HD (A) and CH3 + CH3OH → CH2O + H + CH4 (B). For reaction A, the experiments span a T-range of 1016 K ≤ T ≤ 1325 K, at pressures 0.25 bar ≤ P ≤ 0.46 bar. The experiments on reaction B, CH3 + CH3OH, cover a T-range of 1138 K ≤ T ≤ 1270 K, at pressures around 0.40 bar. Reflected shock tube experiments, monitoring the depletion of D-atoms by applying D-atom atomic resonance absorption spectrometry (ARAS), were performed on reaction A using gas mixtures of C2D5I and CH3OH in Kr bath gas. C2D5I was used as precursor for D-atoms. For reaction B, reflected shock tube experiments monitoring H-atom formation with H-ARAS, were carried out using gas mixtures of diacetyl ((CH3CO)2) and CH3OH in Kr bath gas. (CH3CO)2 was used as the source of CH3-radicals. Detailed reaction models were assembled to fit the D-atom and H-atom time profiles in order to obtain experimental rate constants for reactions A and B. Total rate constants from the present experiments on D + CH3OH and CH3 + CH3OH can be represented by the Arrhenius equations kA(T) = 1.51 × 10(-10) exp(-3843 K/T) cm(3) molecules(-1) s(-1) (1016 K ≤ T ≤ 1325 K) and kB(T) = 9.62 × 10(-12) exp(-7477 K/T) cm(3) molecules(-1) s(-1) (1138 K ≤ T ≤ 1270 K). The experimentally obtained rate constants were compared with available rate data from the literature. The results from quantum chemical studies on reaction A were found to be in good agreement with the present results. The present work represents the first direct experimental study on these bimolecular reactions at combustion temperatures and is important to the high-temperature oxidation of CH3OH.

Spectroscopic Factors from the Single Neutron Pickup Reaction ^64Zn(d,t)

NASA Astrophysics Data System (ADS)

Leach, Kyle; Garrett, P. E.; Ball, G. C.; Bangay, J. C.; Bianco, L.; Demand, G. A.; Faestermann, T.; Finlay, P.; Green, K. L.; Hertenberger, R.; Krücken, R.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wirth, H.-F.; Wong, J.

2009-10-01

A great deal of attention has recently been paid towards high-precision superallowed β-decay Ft values. With the availability of extremely high-precision (<0.1%) experimental data, precision on the individual Ft values are now dominated by the ˜1% theoretical corrections^[1]. This limitation is most evident in heavier superallowed nuclei (e.g. ^62Ga) where the isospin-symmetry-breaking (ISB) correction calculations become more difficult due to the truncated model space. Experimental spectroscopic factors for these nuclei are important for the identification of the relevant orbitals that should be included in the model space of the calculations. Motivated by this need, the single-nucleon transfer reaction ^64Zn(d,t)^63Zn was conducted at the Maier-Leibnitz-Laboratory (MLL) of TUM/LMU in Munich, Germany, using a 22 MeV polarized deuteron beam from the tandem Van de Graaff accelerator and the TUM/LMU Q3D magnetic spectrograph, with angular distributions from 10^o to 60^o. Results from this experiment will be presented and implications for calculations of ISB corrections in the superallowed &+circ; decay of ^62Ga will be discussed.^[1] I.S. Towner and J.C. Hardy, Phys. Rev. C 77, 025501 (2008).

Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.

PubMed

Driver, John P; Chen, Yi-Guang; Mathews, Clayton E

2012-01-01

Although once widely anticipated to unlock how human type 1 diabetes (T1D) develops, extensive study of the nonobese diabetic (NOD) mouse has failed to yield effective treatments for patients with the disease. This has led many to question the usefulness of this animal model. While criticism about the differences between NOD and human T1D is legitimate, in many cases disease in both species results from perturbations modulated by the same genes or different genes that function within the same biological pathways. Like in humans, unusual polymorphisms within an MHC class II molecule contributes the most T1D risk in NOD mice. This insight supports the validity of this model and suggests the NOD has been improperly utilized to study how to cure or prevent disease in patients. Indeed, clinical trials are far from administering T1D therapeutics to humans at the same concentration ranges and pathological states that inhibit disease in NOD mice. Until these obstacles are overcome it is premature to label the NOD mouse a poor surrogate to test agents that cure or prevent T1D. An additional criticism of the NOD mouse is the past difficulty in identifying genes underlying T1D using conventional mapping studies. However, most of the few diabetogenic alleles identified to date appear relevant to the human disorder. This suggests that rather than abandoning genetic studies in NOD mice, future efforts should focus on improving the efficiency with which diabetes susceptibility genes are detected. The current review highlights why the NOD mouse remains a relevant and valuable tool to understand the genes and their interactions that promote autoimmune diabetes and therapeutics that inhibit this disease. It also describes a new range of technologies that will likely transform how the NOD mouse is used to uncover the genetic causes of T1D for years to come.

Change of the binding mode of the DNA/proflavine system induced by ethanol.

PubMed

García, Begoña; Leal, José M; Ruiz, Rebeca; Biver, Tarita; Secco, Fernando; Venturini, M

2010-07-01

The equilibria and kinetics of the binding of proflavine to poly(dG-dC).poly(dG-dC) and poly(dA-dT).poly(dA-dT) were investigated in ethanol/water mixtures using spectrophotometric, circular dichroism, viscometric, and T-jump methods. All methods concur in showing that two modes of interaction are operative: intercalation and surface binding. The latter mode is favored by increasing ethanol and/or the proflavine content. Both static and kinetic experiments show that, concerning the poly(dG-dC).poly(dG-dC)/proflavine system, intercalation largely prevails up to 20% EtOH. For higher EtOH levels surface binding becomes dominant. Concerning the poly(dA-dT).poly(dA-dT)/proflavine system, melting experiments show that addition of proflavine stabilizes the double stranded structure, but the effect is reduced in the presence of EtOH. The DeltaH degrees and DeltaS degrees values of the melting process, measured at different concentrations of added proflavine, are linearly correlated, revealing the presence of the enthalpy-entropy compensation phenomenon (EEC). The nonmonotonicity of the "entropic term" of the EEC reveals the transition between the two binding modes. T-jump experiments show two relaxation effects, but at the highest levels of EtOH (>25%) the kinetic curves become monophasic, confirming the prevalence of the surface complex. A branched mechanism is proposed where diffusion controlled formation of a precursor complex occurs in the early stage of the binding process. This evolves toward the surface and/or the intercalated complex according to two rate-determining parallel steps. CD spectra suggest that, in the surface complex, proflavine is bound to DNA in the form of an aggregate.

A controlled comparison of the BacT/ALERT® 3D and VIRTUO™ microbial detection systems.

PubMed

Totty, H; Ullery, M; Spontak, J; Viray, J; Adamik, M; Katzin, B; Dunne, W M; Deol, P

2017-10-01

The performance of the next-generation BacT/ALERT® VIRTUO™ Microbial Detection System (VIRTUO™, bioMérieux Inc., Hazelwood, MO) was compared to the BacT/ALERT® 3D Microbial Detection System (3D, bioMérieux Inc., Durham, NC) using BacT/ALERT® FA Plus (FA Plus), BacT/ALERT® PF Plus (PF Plus), BacT/ALERT® FN Plus (FN Plus), BacT/ALERT® Standard Aerobic (SA), and BacT/ALERT® Standard Anaerobic (SN) blood culture bottles (bioMérieux Inc., Durham, NC). A seeded limit of detection (LoD) study was performed for each bottle type in both systems. The LoD studies demonstrated that both systems were capable of detecting organisms at nearly identical levels [<10 colony-forming units (CFU) per bottle], with no significant difference. Following LoD determination, a seeded study was performed to compare the time to detection (TTD) between the systems using a panel of clinically relevant microorganisms inoculated at or near the LoD with 0, 4, or 10 mL of healthy human blood. VIRTUO™ exhibited a faster TTD by an average of 3.5 h, as well as demonstrated a significantly improved detection rate of 99.9% compared to 98.8% with 3D (p-value <0.05).

LLE Review 117 (October-December 2008)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bittle, W., editor

2009-05-28

This volume of the LLE Review, covering October-December 2008, features 'Demonstration of the Shock-Timing Technique for Ignition Targets at the National Ignition Facility' by T. R. Boehly, V. N. Goncharov, S. X. Hu, J. A. Marozas, T. C. Sangster, D. D. Meyerhofer (LLE), D. Munro, P. M. Celliers, D. G. Hicks, G. W. Collins, H. F. Robey, O. L. Landen (LLNL), and R. E. Olson (SNL). In this article (p. 1) the authors report on a technique to measure the velocity and timing of shock waves in a capsule contained within hohlraum targets. This technique is critical for optimizing themore » drive profiles for high-performance inertial-confinement-fusion capsules, which are compressed by multiple precisely timed shock waves. The shock-timing technique was demonstrated on OMEGA using surrogate hohlraum targets heated to 180 eV and fitted with a re-entrant cone and quartz window to facilitate velocity measurements using velocity interferometry. Cryogenic experiments using targets filled with liquid deuterium further demonstrated the entire timing technique in a hohlraum environment. Direct-drive cryogenic targets with multiple spherical shocks were also used to validate this technique, including convergence effects at relevant pressures (velocities) and sizes. These results provide confidence that shock velocity and timing can be measured in NIF ignition targets, thereby optimizing these critical parameters.« less

Complete genome sequence of Desulfurivibrio alkaliphilus strain AHT2 T, a haloalkaliphilic sulfidogen from Egyptian hypersaline alkaline lakes

DOE PAGES

Melton, Emily Denise; Sorokin, Dimitry Y.; Overmars, Lex; ...

2016-09-08

Desulfurivibrio alkaliphilus strain AHT2 T is a strictly anaerobic sulfidogenic haloalkaliphile isolated from a composite sediment sample of eight hypersaline alkaline lakes in the Wadi al Natrun valley in the Egyptian Libyan Desert. D. alkaliphilus AHT2 T is Gram-negative and belongs to the family Desulfobulbaceae within the Deltaproteobacteria. Here we report its genome sequence, which contains a 3.10 Mbp chromosome. Here, D. alkaliphilus AHT2 T is adapted to survive under highly alkaline and moderately saline conditions and therefore, is relevant to the biotechnology industry and life under extreme conditions. For these reasons, D. alkaliphilus AHT2 T was sequenced by themore » DOE Joint Genome Institute as part of the Community Science Program.« less

Complete genome sequence of Desulfurivibrio alkaliphilus strain AHT2 T, a haloalkaliphilic sulfidogen from Egyptian hypersaline alkaline lakes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melton, Emily Denise; Sorokin, Dimitry Y.; Overmars, Lex

Desulfurivibrio alkaliphilus strain AHT2 T is a strictly anaerobic sulfidogenic haloalkaliphile isolated from a composite sediment sample of eight hypersaline alkaline lakes in the Wadi al Natrun valley in the Egyptian Libyan Desert. D. alkaliphilus AHT2 T is Gram-negative and belongs to the family Desulfobulbaceae within the Deltaproteobacteria. Here we report its genome sequence, which contains a 3.10 Mbp chromosome. Here, D. alkaliphilus AHT2 T is adapted to survive under highly alkaline and moderately saline conditions and therefore, is relevant to the biotechnology industry and life under extreme conditions. For these reasons, D. alkaliphilus AHT2 T was sequenced by themore » DOE Joint Genome Institute as part of the Community Science Program.« less

Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

NASA Astrophysics Data System (ADS)

Aaltonen, T.; Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Askew, A.; Atkins, S.; Auerbach, B.; Augsten, K.; Aurisano, A.; Aushev, V.; Aushev, Y.; Avila, C.; Azfar, F.; Badaud, F.; Badgett, W.; Bae, T.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barbaro-Galtieri, A.; Barberis, E.; Baringer, P.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartlett, J. F.; Bartos, P.; Bassler, U.; Bauce, M.; Bazterra, V.; Bean, A.; Bedeschi, F.; Begalli, M.; Behari, S.; Bellantoni, L.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Bhatti, A.; Bland, K. R.; Blazey, G.; Blessing, S.; Bloom, K.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Bortoletto, D.; Borysova, M.; Boudreau, J.; Boveia, A.; Brandt, A.; Brandt, O.; Brigliadori, L.; Brochmann, M.; Brock, R.; Bromberg, C.; Bross, A.; Brown, D.; Brucken, E.; Bu, X. B.; Budagov, J.; Budd, H. S.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buszello, C. P.; Butti, P.; Buzatu, A.; Calamba, A.; Camacho-Pérez, E.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Casey, B. C. K.; Castilla-Valdez, H.; Castro, A.; Catastini, P.; Caughron, S.; Cauz, D.; Cavaliere, V.; Cerri, A.; Cerrito, L.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapelain, A.; Chapon, E.; Chen, G.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Cho, S. W.; Choi, S.; Chokheli, D.; Choudhary, B.; Cihangir, S.; Claes, D.; Clark, A.; Clarke, C.; Clutter, J.; Convery, M. E.; Conway, J.; Cooke, M.; Cooper, W. E.; Corbo, M.; Corcoran, M.; Cordelli, M.; Couderc, F.; Cousinou, M.-C.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; Cuth, J.; Cutts, D.; Das, A.; d'Ascenzo, N.; Datta, M.; Davies, G.; de Barbaro, P.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Demortier, L.; Deninno, M.; Denisov, D.; Denisov, S. P.; D'Errico, M.; Desai, S.; Deterre, C.; DeVaughan, K.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dittmann, J. R.; Dominguez, A.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Drutskoy, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Ebina, K.; Edgar, R.; Edmunds, D.; Elagin, A.; Ellison, J.; Elvira, V. D.; Enari, Y.; Erbacher, R.; Errede, S.; Esham, B.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Farrington, S.; Fauré, A.; Feng, L.; Ferbel, T.; Fernández Ramos, J. P.; Fiedler, F.; Field, R.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Flanagan, G.; Forrest, R.; Fortner, M.; Fox, H.; Franc, J.; Franklin, M.; Freeman, J. C.; Frisch, H.; Fuess, S.; Funakoshi, Y.; Galloni, C.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Garfinkel, A. F.; Garosi, P.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gerberich, H.; Gerchtein, E.; Gershtein, Y.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Ginther, G.; Giokaris, N.; Giromini, P.; Glagolev, V.; Glenzinski, D.; Gogota, O.; Gold, M.; Goldin, D.; Golossanov, A.; Golovanov, G.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J.-F.; Grohsjean, A.; Grosso-Pilcher, C.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Guimaraes da Costa, J.; Gutierrez, G.; Gutierrez, P.; Hahn, S. R.; Haley, J.; Han, J. Y.; Han, L.; Happacher, F.; Hara, K.; Harder, K.; Hare, M.; Harel, A.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hauptman, J. M.; Hays, C.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinrich, J.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herndon, M.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hocker, A.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Hong, Z.; Hopkins, W.; Hou, S.; Howley, I.; Hubacek, Z.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Introzzi, G.; Iori, M.; Ito, A. S.; Ivanov, A.; Jabeen, S.; Jaffré, M.; James, E.; Jang, D.; Jayasinghe, A.; Jayatilaka, B.; Jeon, E. J.; Jeong, M. S.; Jesik, R.; Jiang, P.; Jindariani, S.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jones, M.; Jonsson, P.; Joo, K. K.; Joshi, J.; Jun, S. Y.; Jung, A. W.; Junk, T. R.; Juste, A.; Kajfasz, E.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Karmanov, D.; Kasmi, A.; Kato, Y.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Ketchum, W.; Keung, J.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Kiselevich, I.; Kohli, J. M.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kozelov, A. V.; Kraus, J.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kumar, A.; Kupco, A.; Kurata, M.; Kurča, T.; Kuzmin, V. A.; Laasanen, A. T.; Lammel, S.; Lammers, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lebrun, P.; Lee, H. S.; Lee, H. S.; Lee, J. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Leo, S.; Leone, S.; Lewis, J. D.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Limosani, A.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipeles, E.; Lipton, R.; Lister, A.; Liu, H.; Liu, Q.; Liu, T.; Liu, Y.; Lobodenko, A.; Lockwitz, S.; Loginov, A.; Lokajicek, M.; Lopes de Sa, R.; Lucchesi, D.; Lucà, A.; Lueck, J.; Lujan, P.; Lukens, P.; Luna-Garcia, R.; Lungu, G.; Lyon, A. L.; Lys, J.; Lysak, R.; Maciel, A. K. A.; Madar, R.; Madrak, R.; Maestro, P.; Magaña-Villalba, R.; Malik, S.; Malik, S.; Malyshev, V. L.; Manca, G.; Manousakis-Katsikakis, A.; Mansour, J.; Marchese, L.; Margaroli, F.; Marino, P.; Martínez-Ortega, J.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McCarthy, R.; McGivern, C. L.; McNulty, R.; Mehta, A.; Mehtala, P.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Mesropian, C.; Meyer, A.; Meyer, J.; Miao, T.; Miconi, F.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Mondal, N. K.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Mulhearn, M.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nagy, E.; Nakano, I.; Napier, A.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Nett, J.; Neustroev, P.; Nguyen, H. T.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Nunnemann, T.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Okusawa, T.; Orava, R.; Orduna, J.; Ortolan, L.; Osman, N.; Pagliarone, C.; Pal, A.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parashar, N.; Parihar, V.; Park, S. K.; Parker, W.; Partridge, R.; Parua, N.; Patwa, A.; Pauletta, G.; Paulini, M.; Paus, C.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pleier, M.-A.; Podstavkov, V. M.; Pondrom, L.; Popov, A. V.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prewitt, M.; Price, D.; Prokopenko, N.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ripp-Baudot, I.; Ristori, L.; Rizatdinova, F.; Robson, A.; Rodriguez, T.; Rolli, S.; Rominsky, M.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sajot, G.; Sakumoto, W. K.; Sakurai, Y.; Sánchez-Hernández, A.; Sanders, M. P.; Santi, L.; Santos, A. S.; Sato, K.; Savage, G.; Saveliev, V.; Savitskyi, M.; Savoy-Navarro, A.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schlabach, P.; Schmidt, E. E.; Schott, M.; Schwanenberger, C.; Schwarz, T.; Schwienhorst, R.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Sekaric, J.; Semenov, A.; Severini, H.; Sforza, F.; Shabalina, E.; Shalhout, S. Z.; Shary, V.; Shaw, S.; Shchukin, A. A.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shkola, O.; Shochet, M.; Shreyber-Tecker, I.; Simak, V.; Simonenko, A.; Skubic, P.; Slattery, P.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Song, H.; Sonnenschein, L.; Sorin, V.; Soustruznik, K.; St. Denis, R.; Stancari, M.; Stark, J.; Stefaniuk, N.; Stentz, D.; Stoyanova, D. A.; Strauss, M.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Suter, L.; Svoisky, P.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Titov, M.; Toback, D.; Tokar, S.; Tokmenin, V. V.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Tsai, Y.-T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Ukegawa, F.; Uozumi, S.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Vázquez, F.; Velev, G.; Vellidis, C.; Verkheev, A. Y.; Vernieri, C.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vidal, M.; Vilanova, D.; Vilar, R.; Vizán, J.; Vogel, M.; Vokac, P.; Volpi, G.; Wagner, P.; Wahl, H. D.; Wallny, R.; Wang, M. H. L. S.; Wang, S. M.; Warchol, J.; Waters, D.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Wester, W. C.; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Williams, M. R. J.; Wilson, G. W.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wobisch, M.; Wolbers, S.; Wolfmeister, H.; Wood, D. R.; Wright, T.; Wu, X.; Wu, Z.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yamamoto, K.; Yamato, D.; Yang, S.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W.-M.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yeh, G. P.; Yi, K.; Yin, H.; Yip, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Youn, S. W.; Yu, G. B.; Yu, I.; Yu, J. M.; Zanetti, A. M.; Zeng, Y.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhou, C.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.; Zucchelli, S.; CDF Collaboration

2018-01-01

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of √{s }=1.96 TeV . We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is AFBt t ¯=0.128 ±0.025 . The combined inclusive and differential asymmetries are consistent with recent standard model predictions.

Retracted: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population.

PubMed

Liu, Guohui; Zhou, Tian-Biao; Jiang, Zongpei; Zheng, Dongwen

2015-03-01

The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with type-2 diabetic nephropathy (T2DN) susceptibility and the risk of type-2 diabetes mellitus (T2DM) developing into T2DN in Caucasian populations is still controversial. A meta-analysis was performed to evaluate the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Sixteen articles were identified for the analysis of the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. Sensitivity analysis according to sample size of case (<100 vs. ≥100) was also performed, and the results were similar to the non-sensitivity analysis. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future. © The Author(s) 2014.

Biological and Nano-Technological Applications of Artificial DNAs Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases

DTIC Science & Technology

2011-08-19

A) CD, (B) UV, (C) Tm, and (D) titration experiments of d(iG*)8/d(C)8. d(T/A*/T)n WC WC
 d(T/A/T)n Watson – Crick (WC)
 Hoogsteen
 Symmetrical A...base Figure 7. Triplex formation of the natural T/A/T which has one Watson - Crick (WC)-type and one Hoogsteen-type hydrogen-bondings, and the...Final Report for AOARD Grant FA2386-10-1-4033 “Biological and Nano-technological Applications of Artificial DNAs Made Exclusively of Nonnatutal C

Parent stress and child behaviour among young children with type 1 diabetes.

PubMed

Hilliard, M E; Monaghan, M; Cogen, F R; Streisand, R

2011-03-01

Parents of young children with type 1 diabetes (T1D) are responsible for executing a complex daily management regimen and are at risk for elevated levels of stress. Normative misbehaviour during the preschool years can complicate T1D management, and interpretation of behavioural concerns may vary because of child health status and parent stress. Within a paediatric transactional model framework, child characteristics (e.g. behaviour problems, metabolic control) and parent functioning (e.g. parenting stress, anxiety) likely impact one another. Parents of 2- to 6-year-old children with T1D completed self-report measures, including the Pediatric Inventory for Parents (PIP), State-Trait Anxiety Inventory (STAI), Eyberg Child Behavior Inventory (ECBI), and 24-h Recall Interviews. Medical data were obtained by parent report and medical record review. It was hypothesized that greater parent stress and child blood glucose variability would be significantly associated with greater parent-reported child behaviour concerns. Moderate levels of parent stress and child behaviour problems were endorsed; however, parents perceived children's misbehaviour as problematic, particularly with relation to tasks relevant to diabetes management (e.g. bedtimes and mealtimes). Structural equation modelling indicated that greater general anxiety and paediatric parenting stress was associated with parent report of more problematic child behaviour. Blood glucose variability did not significantly contribute to this relationship. The stress experienced by parents of young children with chronic illness appears to relate to their perception of their children's behaviour problems. Parents' experiences with developmentally normative misbehaviour may interfere with disease management and exacerbate parents' stress and the subsequent impact on well-being. Implications for supporting parents and children with T1D are discussed. © 2010 Blackwell Publishing Ltd.

Power Analysis Tutorial for Experimental Design Software

DTIC Science & Technology

2014-11-01

I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-5205 November 2014 Power Analysis Tutorial for Experimental Design Software...16) [Jun 2013]. I N S T I T U T E F O R D E F E N S E A N A L Y S E S IDA Document D-5205 Power Analysis Tutorial for Experimental Design ...Test and Evaluation (T&E) community is increasing its employment of Design of Experiments (DOE), a rigorous methodology for planning and evaluating

Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

PubMed Central

Lee, Siang Ing; Patel, Mitesh; Jones, Christopher M.; Narendran, Parth

2015-01-01

Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes mellitus (T1D). However, evidence of its risks and management is often extrapolated from studies in type 2 diabetic (T2D) patients or the general population. This approach is unsatisfactory given that the underlying pathology, demographics and natural history of the disease differ between T1D and T2D. Furthermore, with a rising life expectancy, a greater number of T1D patients are exposed to the cardiovascular (CV) risk factors associated with an ageing population. The aim of this review is to examine the existing literature around CVD in T1D. We pay particular attention to CVD prevalence, how well we manage risk, potential biomarkers, and whether the studies included the older aged patients (defined as aged over 65). We also discuss approaches to the management of CV risk in the older aged. The available data suggest a significant CVD burden in patients with T1D and poor management of CV risk factors. This is underpinned by a poor evidence base for therapeutic management of CV risk specifically for patients with T1D, and in the most relevant population – the older aged patients. We would suggest that important areas remain to be addressed, particularly exploring the risks and benefits of therapeutic approaches to CVD management in the older aged. PMID:26568811

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

PubMed

Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M; Dupuis, Josee; Chines, Peter S; Lindgren, Cecilia M; Hartl, Christopher; Jackson, Anne U; Chen, Han; Huyghe, Jeroen R; van de Bunt, Martijn; Pearson, Richard D; Kumar, Ashish; Müller-Nurasyid, Martina; Grarup, Niels; Stringham, Heather M; Gamazon, Eric R; Lee, Jaehoon; Chen, Yuhui; Scott, Robert A; Below, Jennifer E; Chen, Peng; Huang, Jinyan; Go, Min Jin; Stitzel, Michael L; Pasko, Dorota; Parker, Stephen C J; Varga, Tibor V; Green, Todd; Beer, Nicola L; Day-Williams, Aaron G; Ferreira, Teresa; Fingerlin, Tasha; Horikoshi, Momoko; Hu, Cheng; Huh, Iksoo; Ikram, Mohammad Kamran; Kim, Bong-Jo; Kim, Yongkang; Kim, Young Jin; Kwon, Min-Seok; Lee, Juyoung; Lee, Selyeong; Lin, Keng-Han; Maxwell, Taylor J; Nagai, Yoshihiko; Wang, Xu; Welch, Ryan P; Yoon, Joon; Zhang, Weihua; Barzilai, Nir; Voight, Benjamin F; Han, Bok-Ghee; Jenkinson, Christopher P; Kuulasmaa, Teemu; Kuusisto, Johanna; Manning, Alisa; Ng, Maggie C Y; Palmer, Nicholette D; Balkau, Beverley; Stančáková, Alena; Abboud, Hanna E; Boeing, Heiner; Giedraitis, Vilmantas; Prabhakaran, Dorairaj; Gottesman, Omri; Scott, James; Carey, Jason; Kwan, Phoenix; Grant, George; Smith, Joshua D; Neale, Benjamin M; Purcell, Shaun; Butterworth, Adam S; Howson, Joanna M M; Lee, Heung Man; Lu, Yingchang; Kwak, Soo-Heon; Zhao, Wei; Danesh, John; Lam, Vincent K L; Park, Kyong Soo; Saleheen, Danish; So, Wing Yee; Tam, Claudia H T; Afzal, Uzma; Aguilar, David; Arya, Rector; Aung, Tin; Chan, Edmund; Navarro, Carmen; Cheng, Ching-Yu; Palli, Domenico; Correa, Adolfo; Curran, Joanne E; Rybin, Dennis; Farook, Vidya S; Fowler, Sharon P; Freedman, Barry I; Griswold, Michael; Hale, Daniel Esten; Hicks, Pamela J; Khor, Chiea-Chuen; Kumar, Satish; Lehne, Benjamin; Thuillier, Dorothée; Lim, Wei Yen; Liu, Jianjun; Loh, Marie; Musani, Solomon K; Puppala, Sobha; Scott, William R; Yengo, Loïc; Tan, Sian-Tsung; Taylor, Herman A; Thameem, Farook; Wilson, Gregory; Wong, Tien Yin; Njølstad, Pål Rasmus; Levy, Jonathan C; Mangino, Massimo; Bonnycastle, Lori L; Schwarzmayr, Thomas; Fadista, João; Surdulescu, Gabriela L; Herder, Christian; Groves, Christopher J; Wieland, Thomas; Bork-Jensen, Jette; Brandslund, Ivan; Christensen, Cramer; Koistinen, Heikki A; Doney, Alex S F; Kinnunen, Leena; Esko, Tõnu; Farmer, Andrew J; Hakaste, Liisa; Hodgkiss, Dylan; Kravic, Jasmina; Lyssenko, Valeri; Hollensted, Mette; Jørgensen, Marit E; Jørgensen, Torben; Ladenvall, Claes; Justesen, Johanne Marie; Käräjämäki, Annemari; Kriebel, Jennifer; Rathmann, Wolfgang; Lannfelt, Lars; Lauritzen, Torsten; Narisu, Narisu; Linneberg, Allan; Melander, Olle; Milani, Lili; Neville, Matt; Orho-Melander, Marju; Qi, Lu; Qi, Qibin; Roden, Michael; Rolandsson, Olov; Swift, Amy; Rosengren, Anders H; Stirrups, Kathleen; Wood, Andrew R; Mihailov, Evelin; Blancher, Christine; Carneiro, Mauricio O; Maguire, Jared; Poplin, Ryan; Shakir, Khalid; Fennell, Timothy; DePristo, Mark; de Angelis, Martin Hrabé; Deloukas, Panos; Gjesing, Anette P; Jun, Goo; Nilsson, Peter; Murphy, Jacquelyn; Onofrio, Robert; Thorand, Barbara; Hansen, Torben; Meisinger, Christa; Hu, Frank B; Isomaa, Bo; Karpe, Fredrik; Liang, Liming; Peters, Annette; Huth, Cornelia; O'Rahilly, Stephen P; Palmer, Colin N A; Pedersen, Oluf; Rauramaa, Rainer; Tuomilehto, Jaakko; Salomaa, Veikko; Watanabe, Richard M; Syvänen, Ann-Christine; Bergman, Richard N; Bharadwaj, Dwaipayan; Bottinger, Erwin P; Cho, Yoon Shin; Chandak, Giriraj R; Chan, Juliana Cn; Chia, Kee Seng; Daly, Mark J; Ebrahim, Shah B; Langenberg, Claudia; Elliott, Paul; Jablonski, Kathleen A; Lehman, Donna M; Jia, Weiping; Ma, Ronald C W; Pollin, Toni I; Sandhu, Manjinder; Tandon, Nikhil; Froguel, Philippe; Barroso, Inês; Teo, Yik Ying; Zeggini, Eleftheria; Loos, Ruth J F; Small, Kerrin S; Ried, Janina S; DeFronzo, Ralph A; Grallert, Harald; Glaser, Benjamin; Metspalu, Andres; Wareham, Nicholas J; Walker, Mark; Banks, Eric; Gieger, Christian; Ingelsson, Erik; Im, Hae Kyung; Illig, Thomas; Franks, Paul W; Buck, Gemma; Trakalo, Joseph; Buck, David; Prokopenko, Inga; Mägi, Reedik; Lind, Lars; Farjoun, Yossi; Owen, Katharine R; Gloyn, Anna L; Strauch, Konstantin; Tuomi, Tiinamaija; Kooner, Jaspal Singh; Lee, Jong-Young; Park, Taesung; Donnelly, Peter; Morris, Andrew D; Hattersley, Andrew T; Bowden, Donald W; Collins, Francis S; Atzmon, Gil; Chambers, John C; Spector, Timothy D; Laakso, Markku; Strom, Tim M; Bell, Graeme I; Blangero, John; Duggirala, Ravindranath; Tai, E Shyong; McVean, Gilean; Hanis, Craig L; Wilson, James G; Seielstad, Mark; Frayling, Timothy M; Meigs, James B; Cox, Nancy J; Sladek, Rob; Lander, Eric S; Gabriel, Stacey; Mohlke, Karen L; Meitinger, Thomas; Groop, Leif; Abecasis, Goncalo; Scott, Laura J; Morris, Andrew P; Kang, Hyun Min; Altshuler, David; Burtt, Noël P; Florez, Jose C; Boehnke, Michael; McCarthy, Mark I

2017-12-19

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

Epidemiology of and Risk Factors for Type 2 Diabetes in Egypt.

PubMed

Hegazi, Refaat; El-Gamal, Mohamed; Abdel-Hady, Nagy; Hamdy, Osama

2015-01-01

Diabetes is a fast-growing health problem in Egypt with a significant impact on morbidity, mortality, and health care resources. Currently, the prevalence of type 2 diabetes (T2D) in Egypt is around 15.6% of all adults aged 20 to 79. To describe the epidemiology, principal causes, associated risk factors, cultural aspects, and challenges that may contribute to the rapid rise in T2D in Egypt. Review of papers in PubMed and relevant gray literature. The International Diabetes Federation (IDF) has identified Egypt as the ninth leading country in the world for the number of patients with T2D. The prevalence of T2D in Egypt was almost tripled over the last 2 decades. This sharp rise could be attributed to either an increased pattern of the traditional risk factors for T2D such as obesity and physical inactivity and change in eating pattern or other risk factors unique to Egypt. These include increased exposure to environmental risk factors like pesticides and increased prevalence of chronic hepatitis C. Prevention, early identification, and effective intervention are integral components of effective T2D care in Egypt. These strategies may reduce the expanding economic burden associated with T2D care. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

PubMed Central

Jason, Flannick; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez; Highland, Heather M.; Dupuis, Josee; Chines, Peter S.; Lindgren, Cecilia M.; Hartl, Christopher; Jackson, Anne U.; Chen, Han; Huyghe, Jeroen R.; van de Bunt, Martijn; Pearson, Richard D.; Kumar, Ashish; Müller-Nurasyid, Martina; Grarup, Niels; Stringham, Heather M.; Gamazon, Eric R.; Lee, Jaehoon; Chen, Yuhui; Scott, Robert A.; Below, Jennifer E.; Chen, Peng; Huang, Jinyan; Go, Min Jin; Stitzel, Michael L.; Pasko, Dorota; Parker, Stephen C. J.; Varga, Tibor V.; Green, Todd; Beer, Nicola L.; Day-Williams, Aaron G.; Ferreira, Teresa; Fingerlin, Tasha; Horikoshi, Momoko; Hu, Cheng; Huh, Iksoo; Ikram, Mohammad Kamran; Kim, Bong-Jo; Kim, Yongkang; Kim, Young Jin; Kwon, Min-Seok; Lee, Juyoung; Lee, Selyeong; Lin, Keng-Han; Maxwell, Taylor J.; Nagai, Yoshihiko; Wang, Xu; Welch, Ryan P.; Yoon, Joon; Zhang, Weihua; Barzilai, Nir; Voight, Benjamin F.; Han, Bok-Ghee; Jenkinson, Christopher P.; Kuulasmaa, Teemu; Kuusisto, Johanna; Manning, Alisa; Ng, Maggie C. Y.; Palmer, Nicholette D.; Balkau, Beverley; Stančáková, Alena; Abboud, Hanna E.; Boeing, Heiner; Giedraitis, Vilmantas; Prabhakaran, Dorairaj; Gottesman, Omri; Scott, James; Carey, Jason; Kwan, Phoenix; Grant, George; Smith, Joshua D.; Neale, Benjamin M.; Purcell, Shaun; Butterworth, Adam S.; Howson, Joanna M. M.; Lee, Heung Man; Lu, Yingchang; Kwak, Soo-Heon; Zhao, Wei; Danesh, John; Lam, Vincent K. L.; Park, Kyong Soo; Saleheen, Danish; So, Wing Yee; Tam, Claudia H. T.; Afzal, Uzma; Aguilar, David; Arya, Rector; Aung, Tin; Chan, Edmund; Navarro, Carmen; Cheng, Ching-Yu; Palli, Domenico; Correa, Adolfo; Curran, Joanne E.; Rybin, Dennis; Farook, Vidya S.; Fowler, Sharon P.; Freedman, Barry I.; Griswold, Michael; Hale, Daniel Esten; Hicks, Pamela J.; Khor, Chiea-Chuen; Kumar, Satish; Lehne, Benjamin; Thuillier, Dorothée; Lim, Wei Yen; Liu, Jianjun; Loh, Marie; Musani, Solomon K.; Puppala, Sobha; Scott, William R.; Yengo, Loïc; Tan, Sian-Tsung; Taylor, Herman A.; Thameem, Farook; Wilson, Gregory; Wong, Tien Yin; Njølstad, Pål Rasmus; Levy, Jonathan C.; Mangino, Massimo; Bonnycastle, Lori L.; Schwarzmayr, Thomas; Fadista, João; Surdulescu, Gabriela L.; Herder, Christian; Groves, Christopher J.; Wieland, Thomas; Bork-Jensen, Jette; Brandslund, Ivan; Christensen, Cramer; Koistinen, Heikki A.; Doney, Alex S. F.; Kinnunen, Leena; Esko, Tõnu; Farmer, Andrew J.; Hakaste, Liisa; Hodgkiss, Dylan; Kravic, Jasmina; Lyssenko, Valeri; Hollensted, Mette; Jørgensen, Marit E.; Jørgensen, Torben; Ladenvall, Claes; Justesen, Johanne Marie; Käräjämäki, Annemari; Kriebel, Jennifer; Rathmann, Wolfgang; Lannfelt, Lars; Lauritzen, Torsten; Narisu, Narisu; Linneberg, Allan; Melander, Olle; Milani, Lili; Neville, Matt; Orho-Melander, Marju; Qi, Lu; Qi, Qibin; Roden, Michael; Rolandsson, Olov; Swift, Amy; Rosengren, Anders H.; Stirrups, Kathleen; Wood, Andrew R.; Mihailov, Evelin; Blancher, Christine; Carneiro, Mauricio O.; Maguire, Jared; Poplin, Ryan; Shakir, Khalid; Fennell, Timothy; DePristo, Mark; de Angelis, Martin Hrabé; Deloukas, Panos; Gjesing, Anette P.; Jun, Goo; Nilsson, Peter; Murphy, Jacquelyn; Onofrio, Robert; Thorand, Barbara; Hansen, Torben; Meisinger, Christa; Hu, Frank B.; Isomaa, Bo; Karpe, Fredrik; Liang, Liming; Peters, Annette; Huth, Cornelia; O'Rahilly, Stephen P; Palmer, Colin N. A.; Pedersen, Oluf; Rauramaa, Rainer; Tuomilehto, Jaakko; Salomaa, Veikko; Watanabe, Richard M.; Syvänen, Ann-Christine; Bergman, Richard N.; Bharadwaj, Dwaipayan; Bottinger, Erwin P.; Cho, Yoon Shin; Chandak, Giriraj R.; Chan, Juliana CN; Chia, Kee Seng; Daly, Mark J.; Ebrahim, Shah B.; Langenberg, Claudia; Elliott, Paul; Jablonski, Kathleen A.; Lehman, Donna M.; Jia, Weiping; Ma, Ronald C. W.; Pollin, Toni I.; Sandhu, Manjinder; Tandon, Nikhil; Froguel, Philippe; Barroso, Inês; Teo, Yik Ying; Zeggini, Eleftheria; Loos, Ruth J. F.; Small, Kerrin S.; Ried, Janina S.; DeFronzo, Ralph A.; Grallert, Harald; Glaser, Benjamin; Metspalu, Andres; Wareham, Nicholas J.; Walker, Mark; Banks, Eric; Gieger, Christian; Ingelsson, Erik; Im, Hae Kyung; Illig, Thomas; Franks, Paul W.; Buck, Gemma; Trakalo, Joseph; Buck, David; Prokopenko, Inga; Mägi, Reedik; Lind, Lars; Farjoun, Yossi; Owen, Katharine R.; Gloyn, Anna L.; Strauch, Konstantin; Tuomi, Tiinamaija; Kooner, Jaspal Singh; Lee, Jong-Young; Park, Taesung; Donnelly, Peter; Morris, Andrew D.; Hattersley, Andrew T.; Bowden, Donald W.; Collins, Francis S.; Atzmon, Gil; Chambers, John C.; Spector, Timothy D.; Laakso, Markku; Strom, Tim M.; Bell, Graeme I.; Blangero, John; Duggirala, Ravindranath; Tai, E. Shyong; McVean, Gilean; Hanis, Craig L.; Wilson, James G.; Seielstad, Mark; Frayling, Timothy M.; Meigs, James B.; Cox, Nancy J.; Sladek, Rob; Lander, Eric S.; Gabriel, Stacey; Mohlke, Karen L.; Meitinger, Thomas; Groop, Leif; Abecasis, Goncalo; Scott, Laura J.; Morris, Andrew P.; Kang, Hyun Min; Altshuler, David; Burtt, Noël P.; Florez, Jose C.; Boehnke, Michael; McCarthy, Mark I.

2017-01-01

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1–5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D. PMID:29257133

Obtaining T1-T2 distribution functions from 1-dimensional T1 and T2 measurements: The pseudo 2-D relaxation model

NASA Astrophysics Data System (ADS)

Williamson, Nathan H.; Röding, Magnus; Galvosas, Petrik; Miklavcic, Stanley J.; Nydén, Magnus

2016-08-01

We present the pseudo 2-D relaxation model (P2DRM), a method to estimate multidimensional probability distributions of material parameters from independent 1-D measurements. We illustrate its use on 1-D T1 and T2 relaxation measurements of saturated rock and evaluate it on both simulated and experimental T1-T2 correlation measurement data sets. Results were in excellent agreement with the actual, known 2-D distribution in the case of the simulated data set. In both the simulated and experimental case, the functional relationships between T1 and T2 were in good agreement with the T1-T2 correlation maps from the 2-D inverse Laplace transform of the full 2-D data sets. When a 1-D CPMG experiment is combined with a rapid T1 measurement, the P2DRM provides a double-shot method for obtaining a T1-T2 relationship, with significantly decreased experimental time in comparison to the full T1-T2 correlation measurement.

Probing the recognition surface of a DNA triplex: binding studies with intercalator-neomycin conjugates.

PubMed

Xue, Liang; Xi, Hongjuan; Kumar, Sunil; Gray, David; Davis, Erik; Hamilton, Paris; Skriba, Michael; Arya, Dev P

2010-07-06

Thermodynamic studies on the interactions between intercalator-neomycin conjugates and a DNA polynucleotide triplex [poly(dA).2poly(dT)] were conducted. To draw a complete picture of such interactions, naphthalene diimide-neomycin (3) and anthraquinone-neomycin (4) conjugates were synthesized and used together with two other analogues, previously synthesized pyrene-neomycin (1) and BQQ-neomycin (2) conjugates, in our investigations. A combination of experiments, including UV denaturation, circular dichroism (CD) titration, differential scanning calorimetry (DSC), and isothermal titration calorimetry (ITC), revealed that all four conjugates (1-4) stabilized poly(dA).2poly(dT) much more than its parent compound, neomycin. UV melting experiments clearly showed that the temperature (T(m3-->2)) at which poly(dA).2poly(dT) dissociated into poly(dA).poly(dT) and poly(dT) increased dramatically (>12 degrees C) in the presence of intercalator-neomycin conjugates (1-4) even at a very low concentration (2 muM). In contrast to intercalator-neomycin conjugates, the increment of T(m3-->2) of poly(dA).2poly(dT) induced by neomycin was negligible under the same conditions. The binding preference of intercalator-neomycin conjugates (1-4) to poly(dA).2poly(dT) was also confirmed by competition dialysis and a fluorescent intercalator displacement assay. Circular dichroism titration studies revealed that compounds 1-4 had slightly larger binding site size ( approximately 7-7.5) with poly(dA).2poly(dT) as compared to neomycin ( approximately 6.5). The thermodynamic parameters of these intercalator-neomycin conjugates with poly(dA).2poly(dT) were derived from an integrated van't Hoff equation using the T(m3-->2) values, the binding site size numbers, and other parameters obtained from DSC and ITC. The binding affinity of all tested ligands with poly(dA).2poly(dT) increased in the following order: neomycin < 1 < 3 < 4 < 2. Among them, the binding constant [(2.7 +/- 0.3) x 10(8) M(-1)] of 2 with poly(dA).2poly(dT) was the highest, almost 1000-fold greater than that of neomycin. The binding of compounds 1-4 with poly(dA).2poly(dT) was mostly enthalpy-driven and gave negative DeltaC(p) values. The results described here suggest that the binding affinity of intercalator-neomycin conjugates for poly(dA).2poly(dT) increases as a function of the surface area of the intercalator moiety.

Analysis of Ignitor Discharges with Double X-point Magnetic Configurations

NASA Astrophysics Data System (ADS)

Airoldi, A.; Cenacchi, G.; Coppi, B.

2008-11-01

The Ignitor experiment was proposed and designed to achieve ignited and sub-ignited conditions in well confined deuterium-tritium plasmas. Thanks to its unique features (high magnetic field up to 13 T, high plasma current up to 11 MA, and high plasma density up to 5 x10^20 m-3), Ignitor is the only device capable of exploring plasma regimes that are relevant to a net power producing D-T reactor and are not accessible to other existing or planned machines. Double X-point scenarios with magnetic field up to 13 T and plasma current up to 9 MA are analyzed. In these configurations, the access to a high confinement state is assumed when the available plasma heating power, supported by the injected auxiliary power, is larger than the L-H threshold value, according to recent suggested scalings The H-regime is modeled by a global reduction of the thermal transport coefficients used for the L-regime. Situations in the presence and in the absence of sawtooth oscillations have been investigated. Quasi-stationary conditions can be attained when a process producing re- distribution of pressure and current profiles is active. B.Coppi, A.Airoldi, F.Bombarda, et al.,Nucl. Fusion 41, 1253 (2001) D.C. McDonald, A.J. Meakins, et al., PPCF 48, A439 (2006).

Transport of Brownian spheroidal nanoparticles in near-wall vascular flows for cancer therapy

NASA Astrophysics Data System (ADS)

Lin, Tiras Y.; Shah, Preyas N.; Smith, Bryan R.; Shaqfeh, Eric S. G.

2016-11-01

The microenvironment local to a tumor is characterized by a leaky vasculature induced by angiogenesis from tumor growth. Small pores form in the blood vessel walls, and these pores provide a pathway for cancer-ameliorating nanoparticle drug carriers. Using both simulations and microfluidics experiments, we investigate the extravasation of nanoparticles through pores. Using Brownian dynamics simulations, we evolve the stochastic equations for both point particles and finite-size spheroids of varying aspect ratio. We investigate the effect of wall shear flow and pore suction flow (Sampson flow) on the extravasation process. We consider pores of two types: physiologically relevant short pores with a length equal to the particle size and long pores which are relevant to diffusion through membranes. Additionally, we perform microfluidics experiments in which the extravasation rates of various nanoparticles tagged with fluorescent dye through pores are measured. In particular, using fluorometry we measure the flux of nanoparticles across a track-etched membrane, which separates two chambers. Our preliminary results indicate that the flux measured from experiment agrees reasonably with the simulations done with long pores, and we discuss the effect of pore length on extravasation. T.Y.L. is supported by the Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG) Program.

[On the question of a practice.].

PubMed

Sévigny, R

1979-01-01

The author, a psycho-sociologist and a professor in the department of sociology at l'Université de Montreal, looks back and reflects on his practice as an intervener in different types of groups. He returns to his first experiences with T-groups and to the analysis of them which he made at the beginning of his practice. Furthermore, this analysis touches on questions that remain very relevant. Thus the author explains why, for social reasons, he came to privilege work with "real groups" rather than that with spontaneous groups. On the basis of twenty years of experience and a view of many group approaches it can be asked whether the question of man in society as a change agent should not be posed to a greater extent within groups. 1) Dans Sociologie A Sociétés, vol. 9, no 2, d'octobre 1977, le lecteur trouvera un article de moi qui préserve une réflexion plus systématique mais sans référence immédiate à ma propre pratique. Oe numéro, entièrement consacré au thème "psychologie, sociologie, intervention" comprend également plusieurs textes qui ne sont pas étrangers à certains thèmes développés ici. On y trouvera aussi de nombreuses références bibliographiques.

The Solar Mass Ejection Imager (SMEI) Space Experiment

DTIC Science & Technology

2015-01-30

Price, S., Radick, R. R., Sagalyn, R., Sinclair, D., Simnett, G. M., Eyles, C. J ., Cooke, M. P., Tappin, S. J ., Kuchar, T ., Mizuno, D. R., Webb, D. F...207. [3] Kaiser, M. L., Kucera, T . A., Davila, J . M., St. Cyr, O. C., Guhathakurta, M., and Christian, E., “The STEREO Mission: An Introduction...D. F., Mizuno, D. R., Buffington, A., Cooke, M. P., Eyles, C. J ., Fry, C. D., Gentile, L. C., Hick, P. P., Holladay, P. E., Howard, T . A., Hewitt

Universal attractor in a highly occupied non-Abelian plasma

NASA Astrophysics Data System (ADS)

Berges, J.; Boguslavski, K.; Schlichting, S.; Venugopalan, R.

2014-06-01

We study the thermalization process in highly occupied non-Abelian plasmas at weak coupling. The nonequilibrium dynamics of such systems is classical in nature and can be simulated with real-time lattice gauge theory techniques. We provide a detailed discussion of this framework and elaborate on the results reported in J. Berges, K. Boguslavski, S. Schlichting, and R. Venugopalan, Phys. Rev. D 89, 074011 (2014), 10.1103/PhysRevD.89.074011 along with novel findings. We demonstrate the emergence of universal attractor solutions, which govern the nonequilibrium evolution on large time scales both for nonexpanding and expanding non-Abelian plasmas. The turbulent attractor for a nonexpanding plasma drives the system close to thermal equilibrium on a time scale t ˜Q-1αs-7/4. The attractor solution for an expanding non-Abelian plasma leads to a strongly interacting albeit highly anisotropic system at the transition to the low-occupancy or quantum regime. This evolution in the classical regime is, within the uncertainties of our simulations, consistent with the "bottom up" thermalization scenario [R. Baier, A. H. Mueller, D. Schiff, and D. T. Son, Phys. Lett. B 502, 51 (2001), 10.1016/S0370-2693(01)00191-5]. While the focus of this paper is to understand the nonequilibrium dynamics in weak coupling asymptotics, we also discuss the relevance of our results for larger couplings in the early time dynamics of heavy ion collision experiments.

Baby MIND Experiment Construction Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antonova, M.; et al.

Baby MIND is a magnetized iron neutrino detector, with novel design features, and is planned to serve as a downstream magnetized muon spectrometer for the WAGASCI experiment on the T2K neutrino beam line in Japan. One of the main goals of this experiment is to reduce systematic uncertainties relevant to CP-violation searches, by measuring the neutrino contamination in the anti-neutrino beam mode of T2K. Baby MIND is currently being constructed at CERN, and is planned to be operational in Japan in October 2017.

A long-lived tritiated titanium target for fast neutron production

NASA Astrophysics Data System (ADS)

Hughey, B. J.

1995-03-01

Diagnostic techniques using neutron beams have a broad spectrum of applications in advanced manufacturing, explosives and contraband detection, medicine, and industry. The most suitable nuclear reaction for producing large fluxes of fast neutrons at low bombarding energy is the H(d,n)-3 He-4, i.e. d-T, reaction. The lifetime of currently used d-T neutron generators is limited by the gradual evolution of tritium gas from the target during bombardment. This paper is a report of work in progress to develop a method for inhibiting the replacement of tritium with beam deuterons and thus preventing the evolution of tritium gas leading to reduced neutron yield. It is anticipated that tritiated target lifetime can be increased by at least an order of magnitude by using a range-thin tritiated titanium target mounted on a substrate with a high hydrogen diffusivity, such as niobium. Lifetime can be further enhanced by increasing the deuteron beam bombarding energy from the typical value of 200 keV to 600 keV. The results of experiments demonstrating the effect of hydrogen diffusion coefficient on concentration of implanted beam deuterons in candidate substrate materials (Cu, Pd, and Nb) are presented, and issues relevant to the fabrication of a tritiated titanium target on a niobium substrate are discussed.

Experimental Guidance of ISB Corrections via Direct Nuclear Reactions

NASA Astrophysics Data System (ADS)

Leach, K. G.; Garrett, P. E.; Ball, G. C.; Bangay, J. C.; Bianco, L.; Demand, G. A.; Faestermann, T.; Finlay, P.; Green, K. L.; Hertenberger, R.; Kriicken, R.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Svensson, C. E.; Towner, I. S.; Triambak, S.; Wirth, H.-F.; Wong, J.

2011-09-01

The most recent isospin-symmetry-breaking corrections, δc, of Towner and Hardy for superallowed Fermi β-decay transitions, have included the opening of specific core orbitals. This change has resulted in significant deviations in some of the δc factors from their previous calculations, and an improved agreement of the individual corrected Script Ft values with the overall world average of the 13 most precise cases. While this is consistent with the conserved-vector-current (CVC) hypothesis of the Standard Model, these new calculations must be thoroughly tested, and guidance must be given for the improvement of calculations for the upper-pf shell nuclei. Using the (d,t) reaction mechanism to probe the single neutron wavefunction overlap, information regarding the relevant shell-model configurations needed in the calculation can be determined. An experiment was therefore performed with a 22 MeV polarized deuterium beam from the MP tandem Van de Graaff accelerator in Munich, Germany. Using the Q3D magnetic spectrograph, and a cathode-strip focal-plane detector, outgoing tritons were analyzed at 9 angles between 10° and 60°, up to an excitation energy of 4.8 MeV. This proceeding reports the motivational and experimental details for the 64Zn(d,t)63Zn transfer work presented.

Measurement of Differential Cross-Sections in the t$$\\bar{t}$$ → ℓ+jets Channel at √s= 1.96 TeV with the D0 Experiment at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kvita, J

2009-04-01

The analysis presented in this thesis focuses on kinematic distributions in the tmore » $$\\bar{t}$$ system and studies in detail selected differential cross sections of top quarks as well as the reconstructed t$$\\bar{t}$$ pair, namely the top quark transverse momentum and the t$$\\bar{t}$$ system mass. The structure of the thesis is organized as follows: first the Standard Model of the particle physics is briefly introduced in Chapter 1, with relevant aspects of electroweak and strong interactions discussed. The physics of the top quark and its properties are then outlined in Chapter 2, together with the motivation for measuring the transverse top quark momentum and other kinematic-related variables of the t$$\\bar{t}$$ system. The concepts of present-day high energy physics collider experiments and the explicit example of Fermilab Tevatron collider and the D0 detector in Chapters 3 and 4 are followed by the description of basic detector-level objects, i.e. tracks, leptons and jets, in Chapter 5; their identification and calibration following in next chapter with the emphasis on the jet energy scale in Chapter 6 and jet identification at the D0. The analysis itself is outlined in Chapter 7 and is structured so that first the data and simulation samples and the basic preselection are described in Chapter 8 and 9, followed by the kinematic reconstruction part in Chapter 10. Chapter 11 on background normalization and Chapter 12 with raw reconstructed spectra results (at the detector-smeared level) are followed by the purity-based background subtraction method and examples of signal-level corrected spectra in Chapter 13. Next, the procedure of correcting measured spectra for detector effects (unfolding) is described in Chapters 14-15, including migration matrix studies, acceptance correction determination as well as the regularized unfolding procedure itself. Final differential cross sections are presented in Chapter 16 with the main results in Figures 16.19-16.20. Summary and discussion close the main analysis part in Chapter 17, supplemented by appendices on the wealthy of analysis control plots of the t$$\\bar{t}$$ → ℓ + jets channel, selected D0 event displays and finally the list of publications and references. Preliminary results of this analysis have been documented in D0 internal notes [UnfoldTop], [p17Top], [p14Top]; as well as presented at conferences [APS08], [APS05]. The author has also been a co-author of more than 135 D0 collaboration publications since 2005. The author has taken part in the jet energy scale calibration efforts performing final closure tests and deriving a correction to jet energy offset due to the suppression of the calorimeter signal. The author has also co-performed the Φ-intercalibration of the hadronic calorimeter and co-supervised the electromagnetic Φ-intercalibration; recently has also been involved in maintaining the jet identification efficiencies measurement as a JetID convener. During the years in Fermilab, many events have taken place in the course of the analysis in persuasion, including more than 170 shifts served for the D0 detector with or without the beam, 168 talks presented with mixed results and reactions; and tens of thousands of code lines in C (and sometimes perhaps even really C++) written while terabytes of data were processed, analyzed, and sometimes also lost. It has been a long but profoundly enriching chapter of my life.« less

Confined water: a Mercedes-Benz model study.

PubMed

Urbic, T; Vlachy, V; Dill, K A

2006-03-16

We study water that is confined within small geometric spaces. We use the Mercedes-Benz (MB) model of water, in NVT and muVT Monte Carlo computer simulations. For MB water molecules between two planes separated by a distance d, we explore the structures, hydrogen bond networks, and thermodynamics as a function of d, temperature T, and water chemical potential mu. We find that squeezing the planes close enough together leads to a vaporization of waters out of the cavity. This vaporization transition has a corresponding peak in the heat capacity of the water. We also find that, in small pores, hydrogen bonding is not isotropic but, rather, it preferentially forms chains along the axis of the cavity. This may be relevant for fast proton transport in pores. Our simulations show oscillations in the forces between the inert plates, due to water structure, even for plate separations of 5-10 water diameters, consistent with experiments by Israelachvili et al. [Nature 1983, 306, 249]. Finally, we find that confinement affects water's heat capacity, consistent with recent experiments of Tombari et al. on Vycor nanopores [J. Chem. Phys. 2005, 122, 104712].

An application of Bandura's 'Four Sources of Self-Efficacy' to the self-management of type 2 diabetes in people with intellectual disability: An inductive and deductive thematic analysis.

PubMed

Maine, Andrew; Dickson, Adele; Truesdale, Maria; Brown, Michael

2017-11-01

Little is known about the successful experiences and positive perceptions of people with intellectual disabilities (ID) self-managing Type 2 Diabetes (T2D). This study sought to address this gap using Bandura's (1977) 'Four Sources of Self-Efficacy' as a framework of enquiry. Semi-structured interviews were conducted with 10 adults with ID. Interviews were recorded, transcribed verbatim and analysed using inductive and deductive thematic analysis RESULTS: Nine sub-themes were identified following analysis of the data: 1) Mastery through knowledge; 2) Mastery through tools and strategies; 3) Mastery through autonomy; 4) Influence of social setting; 5) Positive social comparisons; 6) Positive and negative self-statements; 7) Feedback from caregivers; 8) Adjustment experiences; 9) Symptom awareness. These were mapped onto Bandura's (1977) Four Sources of efficacy enhancement model and were consistent with its proposed mechanisms. The Four Sources model serves as a useful mode of enquiry for exploring people with ID's experiences and perceptions of self-managing diabetes. It also confirms the appropriateness of Self-efficacy as a potential intervention component for this population. However, additional support may be required for people with ID to reflect meaningfully on their experiences and thus have a sense of self-efficacy. This paper builds upon the limited existing literature on people with ID self-managing type 2 diabetes and provides a robust, qualitative account of the participants' experiences, whilst confirming some of the existing challenges, both for people with ID and their supporters. To self-manage with autonomy and overcome the difficulties of adjustment, further strategies such as training and education needs are highlighted. In addition, the meaning and relevance of the Self-efficacy construct is evaluated in the context of people with ID self-managing T2D. This provides useful information in terms of tailoring existing mainstream T2D interventions to meet the needs of people with ID, as such programs are commonly theoretically guided by Self-efficacy. Furthermore, this evaluation provides rationale for the exploration of people with IDs' Self-efficacy in relation to other chronic diseases, such as cardiovascular disease, cancer symptoms and gastrointestinal disorders. Copyright © 2017 Elsevier Ltd. All rights reserved.

Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes

USDA-ARS?s Scientific Manuscript database

Type 2 diabetes (T2DM) affects over 400 million adults worldwide, often occurs on a background of insulin resistance in obesity, and is a leading risk factor for cardiovascular disease. While insulin resistance is known to be a contributing factor to the development of T2DM, the full mechanisms behi...

Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience.

PubMed

Ehlers, Mario R; Nepom, Gerald T

2012-01-01

Reestablishing immune tolerance in type 1 diabetes (T1D), a chronic autoimmune disease, is a major goal. The Immune Tolerance Network (ITN) has initiated eight clinical trials of immunomodulatory therapies in recent-onset T1D over the past decade. Results have been mixed in terms of clinical efficacy, but the studies have provided valuable mechanistic insight that are enhancing our understanding of the disease and guiding the design of future trials. Trials of non-Fc-binding anti-CD3 mAbs have revealed that modulation of this target leads to partial responses, and ITN's AbATE trial led to identification of a robust responder group that could be distinguished from non-responders by baseline metabolic and immunologic features. A pilot study of the combination of IL-2 and rapamycin gave the first demonstration that frequency and function of regulatory T cells (Tregs) can be enhanced in T1D subjects, although the therapy triggered the activation of effectors with transient β-cell dysfunction. Similarly, therapy with anti-thymocyte globulin led to substantial lymphocyte depletion, but also to the activation of the acute-phase response with no clinical benefit during preliminary analyses. These and other results provide mechanistic tools that can be used as biomarkers for safety and efficacy in future trials. Furthermore, our results, together with those of other organizations, notably TrialNet, delineate the roles of the major components of the immune response in T1D. This information is setting the stage for future combination therapy trials. The development of disease-relevant biomarkers will also enable the implementation of innovative trial designs, notably adaptive trials, which will increase efficiencies in terms of study duration and sample size, and which will expedite the conduct of trials in which there are uncertainties about dose response and effect size.

Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes.

PubMed

Imam, Shahnawaz; Elagin, Raya B; Jaume, Juan Carlos

2013-01-01

Patients with Type 1 Diabetes (T1D) are at high risk of developing lacrimal gland dysfunction. We have developed a new model of human T1D using double-transgenic mice carrying HLA-DQ8 diabetes-susceptibility haplotype instead of mouse MHC-class II and expressing the human beta cell autoantigen Glutamic Acid Decarboxylase in pancreatic beta cells. We report here the development of dry eye syndrome (DES) after diabetes induction in our humanized transgenic model. Double-transgenic mice were immunized with DNA encoding human GAD65, either naked or in adenoviral vectors, to induce T1D. Mice monitored for development of diabetes developed lacrimal gland dysfunction. Animals developed lacrimal gland disease (classically associated with diabetes in Non Obese Diabetic [NOD] mice and with T1D in humans) as they developed glucose intolerance and diabetes. Animals manifested obvious clinical signs of dry eye syndrome (DES), from corneal erosions to severe keratitis. Histological studies of peri-bulbar areas revealed lymphocytic infiltration of glandular structures. Indeed, infiltrative lesions were observed in lacrimal/Harderian glands within weeks following development of glucose intolerance. Lesions ranged from focal lymphocytic infiltration to complete acinar destruction. We observed a correlation between the severity of the pancreatic infiltration and the severity of the ocular disease. Our results demonstrate development of DES in association with antigen-specific insulitis and diabetes following immunization with clinically relevant human autoantigen concomitantly expressed in pancreatic beta cells of diabetes-susceptible mice. As in the NOD mouse model and as in human T1D, our animals developed diabetes-associated DES. This specific finding stresses the relevance of our model for studying these human diseases. We believe our model will facilitate studies to prevent/treat diabetes-associated DES as well as human diabetes.

Status-Relevant Experiences and Conspicuous Consumption - the Moderating Role of Prenatal Androgen Exposure.

PubMed

Cornelissen, Gert; Palacios-Fenech, Javier

2016-09-20

In this paper we study consumers' interest in acquiring and displaying expensive luxury products. Based on recent insights in consumer psychology, which build on developments in evolutionary biology, we consider luxury products as "costly signals": wasteful and costly goods, whose purpose is to communicate one's biological fitness, and social status, to others. In line with previous research, we show that experiences that trigger mate attraction goals (Study 1: Exposure to others in bathing outfit) or status display goals (Study 2: Experiencing a vicarious victory of one's favorite sports team) can increase people's interest in luxury products. However, we demonstrate that some individuals are predictably more responsive to those experiences than others. We used a physiological measure (the proportion of the length of the index finger and ring finger of the right hand, 2D:4D) as a proxy for individual differences in exposure to prenatal androgens (i.e., testosterone). This measure has been related to dominant and competitive behavior later in life. We predict and find that individuals with a low 2D:4D (i.e., high exposure to prenatal androgens) were more responsive to the status-relevant experiences: they became more interested in luxury goods after these experiences. This was not the case for high 2D:4D individuals.

Indirect drive ablative Rayleigh-Taylor experiments with rugby hohlraums on OMEGA

NASA Astrophysics Data System (ADS)

Casner, A.; Galmiche, D.; Huser, G.; Jadaud, J.-P.; Liberatore, S.; Vandenboomgaerde, M.

2009-09-01

Results of ablative Rayleigh-Taylor instability growth experiments performed in indirect drive on the OMEGA laser facility [T. R. Boehly, D. L. Brown, S. Craxton et al., Opt. Commun. 133, 495 (1997)] are reported. These experiments aim at benchmarking hydrocodes simulations and ablator instabilities growth in conditions relevant to ignition in the framework of the Laser MégaJoule [C. Cavailler, Plasma Phys. Controlled Fusion 47, 389 (2005)]. The modulated samples under study were made of germanium-doped plastic (CHGe), which is the nominal ablator for future ignition experiments. The incident x-ray drive was provided using rugby-shaped hohlraums [M. Vandenboomgaerde, J. Bastian, A. Casner et al., Phys. Rev. Lett. 99, 065004 (2007)] and was characterized by means of absolute time-resolved soft x-ray power measurements through a dedicated diagnostic hole, shock breakout data and one-dimensional and two-dimensional (2D) side-on radiographies. All these independent x-ray drive diagnostics lead to an actual on-foil flux that is about 50% smaller than laser-entrance-hole measurements. The experimentally inferred flux is used to simulate experimental optical depths obtained from face-on radiographies for an extensive set of initial conditions: front-side single-mode (wavelength λ =35, 50, and 70 μm) and two-mode perturbations (wavelength λ =35 and 70 μm, in phase or in opposite phase). Three-dimensional pattern growth is also compared with the 2D case. Finally the case of the feedthrough mechanism is addressed with rear-side modulated foils.

Three-dimensional quantitative T1 and T2 mapping of the carotid artery: Sequence design and in vivo feasibility.

PubMed

Coolen, Bram F; Poot, Dirk H J; Liem, Madieke I; Smits, Loek P; Gao, Shan; Kotek, Gyula; Klein, Stefan; Nederveen, Aart J

2016-03-01

A novel three-dimensional (3D) T1 and T2 mapping protocol for the carotid artery is presented. A 3D black-blood imaging sequence was adapted allowing carotid T1 and T2 mapping using multiple flip angles and echo time (TE) preparation times. B1 mapping was performed to correct for spatially varying deviations from the nominal flip angle. The protocol was optimized using simulations and phantom experiments. In vivo scans were performed on six healthy volunteers in two sessions, and in a patient with advanced atherosclerosis. Compensation for patient motion was achieved by 3D registration of the inter/intrasession scans. Subsequently, T1 and T2 maps were obtained by maximum likelihood estimation. Simulations and phantom experiments showed that the bias in T1 and T2 estimation was < 10% within the range of physiological values. In vivo T1 and T2 values for carotid vessel wall were 844 ± 96 and 39 ± 5 ms, with good repeatability across scans. Patient data revealed altered T1 and T2 values in regions of atherosclerotic plaque. The 3D T1 and T2 mapping of the carotid artery is feasible using variable flip angle and variable TE preparation acquisitions. We foresee application of this technique for plaque characterization and monitoring plaque progression in atherosclerotic patients. © 2015 Wiley Periodicals, Inc.

Evidence for Stratification of Deuterium-Tritium Fuel in Inertial Confinement Fusion Implosions

NASA Astrophysics Data System (ADS)

Casey, D. T.; Frenje, J. A.; Gatu Johnson, M.; Manuel, M. J.-E.; Rinderknecht, H. G.; Sinenian, N.; Séguin, F. H.; Li, C. K.; Petrasso, R. D.; Radha, P. B.; Delettrez, J. A.; Glebov, V. Yu; Meyerhofer, D. D.; Sangster, T. C.; McNabb, D. P.; Amendt, P. A.; Boyd, R. N.; Rygg, J. R.; Herrmann, H. W.; Kim, Y. H.; Bacher, A. D.

2012-02-01

Measurements of the D(d,p)T (dd) and T(t,2n)He4 (tt) reaction yields have been compared with those of the D(t,n)He4 (dt) reaction yield, using deuterium-tritium gas-filled inertial confinement fusion capsule implosions. In these experiments, carried out on the OMEGA laser, absolute spectral measurements of dd protons and tt neutrons were obtained. From these measurements, it was concluded that the dd yield is anomalously low and the tt yield is anomalously high relative to the dt yield, an observation that we conjecture to be caused by a stratification of the fuel in the implosion core. This effect may be present in ignition experiments planned on the National Ignition Facility.

Evidence for stratification of deuterium-tritium fuel in inertial confinement fusion implosions.

PubMed

Casey, D T; Frenje, J A; Johnson, M Gatu; Manuel, M J-E; Rinderknecht, H G; Sinenian, N; Séguin, F H; Li, C K; Petrasso, R D; Radha, P B; Delettrez, J A; Glebov, V Yu; Meyerhofer, D D; Sangster, T C; McNabb, D P; Amendt, P A; Boyd, R N; Rygg, J R; Herrmann, H W; Kim, Y H; Bacher, A D

2012-02-17

Measurements of the D(d,p)T (dd) and T(t,2n)(4)He (tt) reaction yields have been compared with those of the D(t,n)(4)He (dt) reaction yield, using deuterium-tritium gas-filled inertial confinement fusion capsule implosions. In these experiments, carried out on the OMEGA laser, absolute spectral measurements of dd protons and tt neutrons were obtained. From these measurements, it was concluded that the dd yield is anomalously low and the tt yield is anomalously high relative to the dt yield, an observation that we conjecture to be caused by a stratification of the fuel in the implosion core. This effect may be present in ignition experiments planned on the National Ignition Facility.

Bacterial contamination of platelet components not detected by BacT/ALERT®.

PubMed

Abela, M A; Fenning, S; Maguire, K A; Morris, K G

2018-02-01

To investigate the possible causes for false negative results in BacT/ALERT ® 3D Signature System despite bacterial contamination of platelet units. The Northern Ireland Blood Transfusion Service (NIBTS) routinely extends platelet component shelf life to 7 days. Components are sampled and screened for bacterial contamination using an automated microbial detection system, the BacT/ALERT ® 3D Signature System. We report on three platelet components with confirmed bacterial contamination, which represent false negative BacT/ALERT ® results and near-miss serious adverse events. NIBTS protocols for risk reduction of bacterial contamination of platelet components are described. The methodology for bacterial detection using BacT/ALERT ® is outlined. Laboratory tests, relevant patient details and relevant follow-up information are analysed. In all three cases, Staphylococcus aureus was isolated from the platelet residue and confirmed on terminal sub-culture using BacT/ALERT ® . In two cases, S. aureus with similar genetic makeup was isolated from the donors. Risk reduction measures for bacterial contamination of platelet components are not always effective. Automated bacterial culture detection does not eliminate the risk of bacterial contamination. Visual inspection of platelet components prior to release, issue and administration remains an important last line of defence. © 2017 British Blood Transfusion Society.

Deuterium-Tritium Beta-Layering Within a National Ignition Facility Scale Polymer Target in the LANL Cryogenic Pressure Loader

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebey, Peter S.; Dole, James M.; Geller, Drew A.

2005-11-15

Beta-layering, the process of beta-decay heat-driven mass redistribution, has been demonstrated in a deuterium-tritium (D-T)-filled polymer sphere of the type required for fusion ignition experiments at the National Ignition Facility. This is the first report, to the best of the authors' knowledge, of a D-T layer formed in a permeation-filled sphere. The 2-mm-diam sphere was filled with D-T by permeation; cooled to cryogenic temperatures while in the high-pressure permeation vessel; and, while cold, removed to an optical axis where the D-T was frozen, melted, and beta-layered in a series of experiments over several weeks' time. This work was performed inmore » the Los Alamos National Laboratory cryogenic pressure loader system. The beta-layering time constant was 24.0 {+-} 2.5 min, less than the theoretical value of 26.8 min, and not showing the significant increase due to build-up of {sup 3}He often observed in beta-layered samples. Supercooling of the liquid D-T was observed. Neither the polymer target nor its tenting material showed visual signs of degradation after 5 weeks of exposure to D-T. Small external thermal gradients were used to shift the D-T material back and forth within the sphere.« less

3D printed lattices as an activation and expansion platform for T cell therapy.

PubMed

Delalat, Bahman; Harding, Frances; Gundsambuu, Batjargal; De-Juan-Pardo, Elena M; Wunner, Felix M; Wille, Marie-Luise; Jasieniak, Marek; Malatesta, Kristen A L; Griesser, Hans J; Simula, Antonio; Hutmacher, Dietmar W; Voelcker, Nicolas H; Barry, Simon C

2017-09-01

One of the most significant hurdles to the affordable, accessible delivery of cell therapy is the cost and difficulty of expanding cells to clinically relevant numbers. Immunotherapy to prevent autoimmune disease, tolerate organ transplants or target cancer critically relies on the expansion of specialized T cell populations. We have designed 3D-printed cell culture lattices with highly organized micron-scale architectures, functionalized via plasma polymerization to bind monoclonal antibodies that trigger cell proliferation. This 3D technology platform facilitate the expansion of therapeutic human T cell subsets, including regulatory, effector, and cytotoxic T cells while maintaining the correct phenotype. Lentiviral gene delivery to T cells is enhanced in the presence of the lattices. Incorporation of the lattice format into existing cell culture vessels such as the G-Rex system is feasible. This cell expansion platform is user-friendly and expedites cell recovery and scale-up, making it ideal for translating T cell therapies from bench to bedside. Copyright © 2017 Elsevier Ltd. All rights reserved.

Thermonuclear Reaction Rate of T(t,2n) α Measured in ICF Plasmas

NASA Astrophysics Data System (ADS)

Brune, C. R.; Casey, D. T.; Caggiano, J. A.; Hatarik, R.; McNabb, D. P.; Sayre, D. B.; Smalyuk, V. A.; Bacher, A. D.; Frenje, J. A.; Gatu-Johnson, M.; Zylstra, A. B.; Couder, M.

2014-09-01

Measurements of charged-particle reactivity have been performed in inertial confinement fusion experiments at the National Ignition Facility. Time-of-flight detectors were used to measure neutrons from the T(t,2n) and T(d,n) reactions produced by implosions with tritium-filled targets (0.1% deuterium). Along with the measured target fuel composition and reactant ion temperature, the well-known T(d,n) reactivity was used to convert the measured neutron yields into a T(t,2n) reactivity. The ion temperature was determined to be 3.3(3) keV, corresponding to an effective energy of 16 keV. In comparison to accelerator measurements of the low-energy T(t,2n) cross section, the source of all previous data, our experiment has resulted in T(t,2n) data with better statistics and lower backgrounds.

The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression.

PubMed

Ghiringhelli, Francois; Ménard, Cédric; Martin, Francois; Zitvogel, Laurence

2006-12-01

Tumor immunosurveillance relies on cognate immune effectors [lymphocytes and interferon-gamma (IFN-gamma)] and innate immunity [natural killer (NK) cells, natural killer group 2, member D (NKG2D) ligands, perforin/granzyme, and tumor necrosis factor-related apoptosis-inducing ligand]. In parallel, tumor cells promote the expansion of CD4(+)CD25(+) regulatory T cells (Tregs) that counteract T-cell-based anti-tumor immunity. Moreover, accumulating evidence points to a critical role for Tregs in dampening NK cell immune responses. This review summarizes the findings showing that Tregs suppress NK cell effector functions in vitro and in vivo, i.e. homeostatic proliferation, cytotoxicity, and interleukin-12-mediated IFN-gamma production. The molecular mechanism involve selective expression of membrane-bound transforming growth factor-beta on Tregs, which downregulate NKG2D expression on NK cells in vitro and in vivo. The regulatory events dictating NK cell suppression by Tregs have been studied and are discussed. The pathological relevance of the Treg-NK cell interaction has been brought up in tumor models and in patients with cancer. Consequently, inhibition of Tregs through pharmacological interventions should be considered during NK-cell-based immunotherapy of cancer.

Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan

PubMed Central

2014-01-01

Background The importance of mitochondrial DNA (mtDNA) polymorphism in the prediction of type 2 diabetes (T2D) in men and women is not well understood. We questioned whether mtDNA polymorphism, mitochondrial functions, age and gender influenced the occurrence of T2D with or without ischemic stroke (IS). Methods We first designed a matched case–control study of 373 T2D patients and 327 healthy unrelated individuals without history of IS. MtDNA haplogroups were determined on all participants using sequencing of the control region and relevant SNPs from the coding region. Mitochondria functional tests, systemic biochemical measurements and complete genomic mtDNA sequencing were further determined on 239 participants (73 healthy controls, 33 T2D with IS, 70 T2D only and 63 IS patients without T2D). Results MtDNA haplogroups B4a1a, and E2b1 showed significant association with T2D (P <0.05), and haplogroup D4 indicated resistance (P <0.05). Mitochondrial and systemic functional tests showed significantly less variance within groups bearing the same mtDNA haplotypes. There was a pronounced male excess among all T2D patients and prevalence of IS was seen only in the older population. Finally, nucleotide variant np 15746, a determinant of haplogroup G3 seen in Japanese and of B4a1a prevalent in Taiwanese was associated with T2D in both populations. Conclusions Men appeared more susceptible to T2D than women. Although the significant association of B4a1a and E2b1 with T2D ceased when corrected for multiple testings, these haplogroups are seen only among Taiwan Aborigines, Southeast Asian and the Pacific Ocean islanders where T2D is predominant. The data further suggested that physiological and biochemical measurements were influenced by the mtDNA genetic profile of the individual. More understanding of the function of the mitochondrion in the development of T2D might indicate ways of influencing the early course of the disease. PMID:24713204

Socio-behavioral considerations in the role of militant extremism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernard, Michael Lewis; Backus, George A.; Beyeler, Walter E.

This paper discusses relevant findings and theories regarding the role of ideology, culture, and context in shaping the behaviors of individuals within violent social movements. Accordingly, this focus concerns the comparative weight placed on ideology and culture (expressed principles and motives) versus external factors as chief influencers for the propensity of individuals to act outside of the norms of society and politics by resorting to violent behaviors. In doing so, we have drawn upon theory from anthropology, behavioral economics, political science, psychology, and sociology to better understand how these variables give birth to and nurture militant social movements. F umore » r t h e r d i s s e m i n a t i o n o n l y a s a u t h o r i z e d t o U . S . G o v e r n m e n t a g e n c i e s a n d t h e i r c o n t r a c t o r s ; o t h e r r e q u e s t s s h a l l b e a p p r o v e d b y t h e o r i g i n a t i n g f a c i l i t y o r h i g h e r D O E p r o g r a m m a t i c a u t h o r i t y .« less

SOCIO-BEHAVIORALCONSIDERATIONS IN THE ROLE OF MILITANT EXTREMISM.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernard, Michael Lewis; Backus, George A.; Beyeler, Walter E.

This paper discusses relevant findings and theories regarding the role of ideology, culture, and context in shaping the behaviors of individuals within violent social movements. Accordingly, this focus concerns the comparative weight placed on ideology and culture (expressed principles and motives) versus external factors as chief influencers for the propensity of individuals to act outside of the norms of society and politics by resorting to violent behaviors. In doing so, we have drawn upon theory from anthropology, behavioral economics, political science, psychology, and sociology to better understand how these variables give birth to and nurture militant social movements. F umore » r t h e r d i s s e m i n a t i o n o n l y a s a u t h o r i z e d t o U . S . G o v e r n m e n t a g e n c i e s a n d t h e i r c o n t r a c t o r s ; o t h e r r e q u e s t s s h a l l b e a p p r o v e d b y t h e o r i g i n a t i n g f a c i l i t y o r h i g h e r D O E p r o g r a m m a t i c a u t h o r i t y .« less

An NQR Study of TNT Characteristics.

DTIC Science & Technology

1977-09-01

RDX , HMX , a r d some of t he heavy me t al 3~~: id~.s h~~’n for rn.nn ye.~rs been use d as rn~~lit~~ry nii p lns i n’t-~~~~, Thr p h y s i c a l...ambient temperatures of more than one coexisting crystal phase. This polymorphism is known to occur in TNT , HMX and PbN3, and is responsible for a...specific problems of TNT polymorphism and phase transitions were researched . This is one of the problems which is relevant to present day concerns . The

A Cylindrical, Inner Volume Selecting 2D-T2-Prep Improves GRAPPA-Accelerated Image Quality in MRA of the Right Coronary Artery

PubMed Central

Coristine, Andrew J.; Yerly, Jerome; Stuber, Matthias

2016-01-01

Background Two-dimensional (2D) spatially selective radiofrequency (RF) pulses may be used to excite restricted volumes. By incorporating a "pencil beam" 2D pulse into a T2-Prep, one may create a "2D-T2-Prep" that combines T2-weighting with an intrinsic outer volume suppression. This may particularly benefit parallel imaging techniques, where artefacts typically originate from residual foldover signal. By suppressing foldover signal with a 2D-T2-Prep, image quality may therefore improve. We present numerical simulations, phantom and in vivo validations to address this hypothesis. Methods A 2D-T2-Prep and a conventional T2-Prep were used with GRAPPA-accelerated MRI (R = 1.6). The techniques were first compared in numerical phantoms, where per pixel maps of SNR (SNRmulti), noise, and g-factor were predicted for idealized sequences. Physical phantoms, with compartments doped to mimic blood, myocardium, fat, and coronary vasculature, were scanned with both T2-Preparation techniques to determine the actual SNRmulti and vessel sharpness. For in vivo experiments, the right coronary artery (RCA) was imaged in 10 healthy adults, using accelerations of R = 1,3, and 6, and vessel sharpness was measured for each. Results In both simulations and phantom experiments, the 2D-T2-Prep improved SNR relative to the conventional T2-Prep, by an amount that depended on both the acceleration factor and the degree of outer volume suppression. For in vivo images of the RCA, vessel sharpness improved most at higher acceleration factors, demonstrating that the 2D-T2-Prep especially benefits accelerated coronary MRA. Conclusion Suppressing outer volume signal with a 2D-T2-Prep improves image quality particularly well in GRAPPA-accelerated acquisitions in simulations, phantoms, and volunteers, demonstrating that it should be considered when performing accelerated coronary MRA. PMID:27736866

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer's Disease and Type 2 Diabetes.

PubMed

Infante-Garcia, Carmen; Ramos-Rodriguez, Juan Jose; Hierro-Bujalance, Carmen; Ortegon, Esperanza; Pickett, Eleanor; Jackson, Rosemary; Hernandez-Pacho, Fernando; Spires-Jones, Tara; Garcia-Alloza, Monica

2018-07-01

Type 2 diabetes (T2D) is an important risk factor to suffer dementia, being Alzheimer's disease (AD) as the most common form. Both AD and T2D are closely related to aging and with a growing elderly population it might be of relevance to explore new therapeutic approaches that may slow or prevent central complications associated with metabolic disorders. Therefore, we propose the use of the antidiabetic polypill (PP), a pharmacological cocktail, commonly used by T2D patients that include metformin, aspirin, simvastatin, and an angiotensin-converting enzyme inhibitor. In order to test the effects of PP at the central level, we have long-term treated a new mixed model of AD-T2D, the APP/PS1xdb/db mouse. We have analyzed AD pathological features and the underlying specific characteristics that relate AD and T2D. As expected, metabolic alterations were ameliorated after PP treatment in diabetic mice, supporting a role for PP in maintaining pancreatic activity. At central level, PP reduced T2D-associated brain atrophy, showing both neuronal and synaptic preservation. Tau and amyloid pathologies were also reduced after PP treatment. Furthermore, we observed a reduction of spontaneous central bleeding and inflammation after PP treatment in diabetic mice. As consequence, learning and memory processes were improved after PP treatment in AD, T2D, and AD-T2D mice. Our data provide the basis to further analyze the role of PP, as an alternative or adjuvant, to slow down or delay the central complications associated with T2D and AD.

Partitioning of Ni, Co and V between Spinel-Structured Oxides and Silicate Melts: Importance of Spinel Composition

NASA Technical Reports Server (NTRS)

Righter, K.; Leeman, W. P.; Hervig, R. L.

2006-01-01

Partitioning of Ni, Co and V between Cr-rich spinels and basaltic melt has been studied experimentally between 1150 and 1325 C, and at controlled oxygen fugacity from the Co-CoO buffer to slightly above the hematite magnetite buffer. These new results, together with new Ni, Co and V analyses of experimental run products from Leeman [Leeman, W.P., 1974. Experimental determination of the partitioning of divalent cations between olivine and basaltic liquid, Pt. II. PhD thesis, Univ. Oregon, 231 - 337.], show that experimentally determined spinel melt partition coefficients (D) are dependent upon temperature (T), oxygen fugacity (fO2) and spinel composition. In particular, partition coefficients determined on doped systems are higher than those in natural (undoped) systems, perhaps due to changing activity coefficients over the composition range defined by the experimental data. Using our new results and published runs (n =85), we obtain a multilinear regression equation that predicts experimental D(V) values as a function of T, fO2, concentration of V in melt and spinel composition. This equation allows prediction of D(V) spinel/melt values for natural mafic liquids at relevant crystallization conditions. Similarly, D(Ni) and D(Co) values can be inferred from our experiments at redox conditions approaching the QFM buffer, temperatures of 1150 to 1250 C and spinel composition (early Cr-bearing and later Ti-magnetite) appropriate for basic magma differentiation. When coupled with major element modelling of liquid lines of descent, these values (D(Ni) sp/melt=10 and D(Co) sp/melt=5) closely reproduce the compositional variation observed in komatiite, mid-ocean ridge basalt (MORB), ocean island basalt (OIB) and basalt to rhyolite suites.

A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes.

PubMed

Louis, Fiona; Pannetier, Pauline; Souguir, Zied; Le Cerf, Didier; Valet, Philippe; Vannier, Jean-Pierre; Vidal, Guillaume; Demange, Elise

2017-08-01

The lack of relevant in vitro models for adipose tissue makes necessary the development of a more physiological environment providing spatial and chemical cues for the effective maturation of adipocytes. We developed a biofunctionalized hydrogel with components of adipose extracellular matrix: collagen I, collagen VI, and the cell binding domain of fibronectin and we compared it to usual 2D cultures on plastic plates. This scaffold allowed 3D culture of mature adipocytes from the preadipocytes cell lines 3T3-L1 and 3T3-F442A, as well as primary Human White Preadipocytes (HWP), acquiring in vivo-like organization, with spheroid shaped adipocytes forming multicellular aggregates. The size of these aggregates increased with time up to 120 μm in diameter after 4 weeks of maturation, with good viability. Significantly higher lipogenic activity (up to 20-fold at day 28 for HWP cultures) and differentiation rates were also observed compared to 2D. Gene expression analyses highlighted earlier differentiation and complete maturation of 3D HWP compared to 2D, reinforced by the expression of Perilipin protein after 21 days of nutrition. This increase in adipocytes phenotypic and genotypic markers made this scaffold-driven culture as a robust adipose 3D model. Retinoic acid inhibition of lipogenesis in HWP or isoprenalin and caffeine induction of lipolysis performed on mouse 3T3-F442A cells, showed higher doses of molecules than typically used in 2D, underlying the physiologic relevance of this 3D culture system. Biotechnol. Bioeng. 2017;114: 1813-1824. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Convection in a Very Compressible Fluid: Comparison of Simulations With Experiments

NASA Technical Reports Server (NTRS)

Meyer, H.; Furukawa, A.; Onuki, A.; Kogan, A. B.

2003-01-01

The time profile (Delta)T(t) of the temperature difference, measured across a very compressible fluid layer of supercritical He-3 after the start of a heat flow, shows a damped oscillatory behavior before steady state convection is reached. The results for (Delta)T(t) obtained from numerical simulations and from laboratory experiments are compared over a temperature range where the compressibility varies by a factor of approx. = 40. First the steady-state convective heat current j(sup conv) as a function of the Rayleigh number R(alpha) is presented, and the agreement is found to be good. Second, the shape of the time profile and two characteristic times in the transient part of (Delta)T(t) from simulations and experiments are compared, namely: 1) t(sub osc), the oscillatory period and 2) t(sub p), the time of the first peak after starting the heat flow. These times, scaled by the diffusive time tau(sub D) versus R(alpha), are presented. The agreement is good for t(sup osc)/tau(sub D), where the results collapse on a single curve showing a powerlaw behavior. The simulation hence confirms the universal scaling behavior found experimentally. However for t(sub p)/tau(sub D), where the experimental data also collapse on a single curve, the simulation results show systematic departures from such a behavior. A possible reason for some of the disagreements, both in the time profile and in t(sub p) is discussed. In the Appendix a third characteristic time, t(sub m), between the first peak and the first oscillation minimum is plotted and a comparison between the results of experiments and simulations is made.

Statistical models to predict type 2 diabetes remission after bariatric surgery.

PubMed

Ramos-Levi, Ana M; Matia, Pilar; Cabrerizo, Lucio; Barabash, Ana; Sanchez-Pernaute, Andres; Calle-Pascual, Alfonso L; Torres, Antonio J; Rubio, Miguel A

2014-09-01

Type 2 diabetes (T2D) remission may be achieved after bariatric surgery (BS), but rates vary according to patients' baseline characteristics. The present study evaluates the relevance of several preoperative factors and develops statistical models to predict T2D remission 1 year after BS. We retrospectively studied 141 patients (57.4% women), with a preoperative diagnosis of T2D, who underwent BS in a single center (2006-2011). Anthropometric and glucose metabolism parameters before surgery and at 1-year follow-up were recorded. Remission of T2D was defined according to consensus criteria: HbA1c <6%, fasting glucose (FG) <100 mg/dL, absence of pharmacologic treatment. The influence of several preoperative factors was explored and different statistical models to predict T2D remission were elaborated using logistic regression analysis. Three preoperative characteristics considered individually were identified as the most powerful predictors of T2D remission: C-peptide (R2  = 0.249; odds ratio [OR] 1.652, 95% confidence interval [CI] 1.181-2.309; P = 0.003), T2D duration (R2  = 0.197; OR 0.869, 95% CI 0.808-0.935; P < 0.001), and previous insulin therapy (R2  = 0.165; OR 4.670, 95% CI 2.257-9.665; P < 0.001). High C-peptide levels, a shorter duration of T2D, and the absence of insulin therapy favored remission. Different multivariate logistic regression models were designed. When considering sex, T2D duration, and insulin treatment, remission was correctly predicted in 72.4% of cases. The model that included age, FG and C-peptide levels resulted in 83.7% correct classifications. When sex, FG, C-peptide, insulin treatment, and percentage weight loss were considered, correct classification of T2D remission was achieved in 95.9% of cases. Preoperative characteristics determine T2D remission rates after BS to different extents. The use of statistical models may help clinicians reliably predict T2D remission rates after BS. © 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Personal History of Nucleon Polarization Experiments

DOE R&D Accomplishments Database

Chamberlain, O.

1984-09-01

The history of nucleon scattering experiments is reviewed, starting with the observation of large proton polarizations in scattering from light elements such as carbon, and ending with the acceleration of polarized proton beams in high-energy synchrotrons. Special mention is made about significant contributions made by C.L. Oxley, L. Wolfenstein, R.D. Tripp, T. Ypsilantis, A. Abragam, M. Borghini, T. Niinikoski, Froissart, Stora, A.D. Krisch, and L.G. Ratner.

Relevant optical properties for direct restorative materials.

PubMed

Pecho, Oscar E; Ghinea, Razvan; do Amaral, Erika A Navarro; Cardona, Juan C; Della Bona, Alvaro; Pérez, María M

2016-05-01

To evaluate relevant optical properties of esthetic direct restorative materials focusing on whitened and translucent shades. Enamel (E), body (B), dentin (D), translucent (T) and whitened (Wh) shades for E (WhE) and B (WhB) from a restorative system (Filtek Supreme XTE, 3M ESPE) were evaluated. Samples (1 mm thick) were prepared. Spectral reflectance (R%) and color coordinates (L*, a*, b*, C* and h°) were measured against black and white backgrounds, using a spectroradiometer, in a viewing booth, with CIE D65 illuminant and d/0° geometry. Scattering (S) and absorption (K) coefficients and transmittance (T%) were calculated using Kubelka-Munk's equations. Translucency (TP) and opalescence (OP) parameters and whiteness index (W*) were obtained from differences of CIELAB color coordinates. R%, S, K and T% curves from all shades were compared using VAF (Variance Accounting For) coefficient with Cauchy-Schwarz inequality. Color coordinates and optical parameters were statistically analyzed using one-way ANOVA, Tukey's test with Bonferroni correction (α=0.0007). Spectral behavior of R% and S were different for T shades. In addition, T shades showed the lowest R%, S and K values, as well as the highest T%, TP an OP values. In most cases, WhB shades showed different color and optical properties (including TP and W*) than their corresponding B shades. WhE shades showed similar mean W* values and higher mean T% and TP values than E shades. When using whitened or translucent composites, the final color is influenced not only by the intraoral background but also by the color and optical properties of multilayers used in the esthetic restoration. Copyright © 2016 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Numerical Mantle Convection Models With a Flexible Thermodynamic Interface

NASA Astrophysics Data System (ADS)

van den Berg, A. P.; Jacobs, M. H.; de Jong, B. H.

2001-12-01

Accurate material properties are needed for deep mantle (P,T) conditions in order to predict the longterm behavior of convection planetary mantles. Also the interpretation of seismological observations concerning the deep mantle in terms of mantle flow models calls for a consistent thermodynamical description of the basic physical parameters. We have interfaced a compressible convection code using the anelastic liquid approach based on finite element methods, to a database containing a full thermodynamic description of mantle silicates (Ita and King, J. Geophys. Res., 99, 15,939-15,940, 1994). The model is based on high resolution (P,T) tables of the relevant thermodynamic properties containing typically 50 million (P,T) table gridpoints to obtain resolution in (P,T) space of 1 K and an equivalent of 1 km. The resulting model is completely flexible such that numerical mantle convection experiments can be performed for any mantle composition for which the thermodynamic database is available. We present results of experiments for 2D cartesian models using a data base for magnesium-iron silicate in a pyrolitic composition (Stixrude and Bukowinski, Geoph.Monogr.Ser., 74, 131-142, 1993) and a recent thermodynamical model for magnesium silicate for the complete mantle (P,T) range, (Jacobs and Oonk, Phys. Chem. Mineral, 269, inpress 2001). Preliminary results of bulksound velocity distribution derived in a consistent way from the convection results and the thermodynamic database show a `realistic' mantle profile with bulkvelocity variations decreasing from several percent in the upper mantle to less than a percent in the deep lower mantle.

Effects of lipid sources, lysophospholipids and organic acids in maize-based broiler diets on nutrient balance, liver concentration of fat-soluble vitamins, jejunal microbiota and performance.

PubMed

Polycarpo, G V; Burbarelli, M F C; CarÃo, A C P; Merseguel, C E B; Dadalt, J C; Maganha, S R L; Sousa, R L M; Cruz-Polycarpo, V C; Albuquerque, R

2016-12-01

Three experiments with a 2 × 2 × 2 factorial arrangement were conducted to evaluate maize-based diets for broilers containing different lipid sources [soybean oil (S) or beef tallow (T)] supplemented with or without lysophospholipids and organic acids on nutrient balance (Experiment I, evaluation period of 10-14 d), on liver concentration of fat-soluble vitamins, on jejunal microbiota (Experiment II, sampling at d 14) and on performance (Experiment III, accumulated periods of 1-14, 1-21 and 1-42 d). A total of 1344 male chicks were used. In each experiment, the birds were allotted in a completely randomised design with 8 replications. The lysophospholipids were mainly composed of lysolecithins and the organic acids blend was constituted by lactic (40%), acetic (7%) and butyric acids (1%). An interaction between lipid sources and lysophospholipids was observed on faecal apparent digestibility of lipid (ADL), which improved with lysophospholipids addition in T diets. Broilers fed on S had higher ADL and faecal apparent digestibility of nitrogen-corrected gross energy (ADGE N ). It was not possible to demonstrate a significant treatment effect on the liver concentration of vitamins A and E, even with the differences in fatty acid profile between S and T. Enterobacteria values were below the detection threshold. Lysophospholipid supplementation reduced gram-positive cocci in T-fed birds. S diets promoted lower total anaerobe counts compared with T diets, independent of additives. S diets increased BW gain and feed:gain ratio in all evaluation periods. Lysophospholipids and organic acids improved feed:gain ratio at 1-21 d in T diets. Furthermore, main effects were observed for lysophospholipids and organic acids at 1-42 d, which increased BW gain and improved feed:gain ratio, respectively. No positive interactions between additives were found.

Conceptual processing in music as revealed by N400 effects on words and musical targets.

PubMed

Daltrozzo, Jérôme; Schön, Daniele

2009-10-01

The cognitive processing of concepts, that is, abstract general ideas, has been mostly studied with language. However, other domains, such as music, can also convey concepts. Koelsch et al. [Koelsch, S., Kasper, E., Sammler, D., Schulze, K., Gunter, T., & Friederici, A. D. Music, language and meaning: Brain signatures of semantic processing. Nature Neuroscience, 7, 302-307, 2004] showed that 10 sec of music can influence the semantic processing of words. However, the length of the musical excerpts did not allow the authors to study the effect of words on musical targets. In this study, we decided to replicate Koelsch et al. findings using 1-sec musical excerpts (Experiment 1). This allowed us to study the reverse influence, namely, of a linguistic context on conceptual processing of musical excerpts (Experiment 2). In both experiments, we recorded behavioral and electrophysiological responses while participants were presented 50 related and 50 unrelated pairs (context/target). Experiments 1 and 2 showed a larger N400 component of the event-related brain potentials to targets following a conceptually unrelated compared to a related context. The presence of an N400 effect with musical targets suggests that music may convey concepts. The relevance of these results for the comprehension of music as a structured set of conceptual units and for the domain specificity of the mechanisms underlying N400 effects are discussed.

Preliminary experience with a novel method of three-dimensional co-registration of prostate cancer digital histology and in vivo multiparametric MRI.

PubMed

Orczyk, C; Rusinek, H; Rosenkrantz, A B; Mikheev, A; Deng, F-M; Melamed, J; Taneja, S S

2013-12-01

To assess a novel method of three-dimensional (3D) co-registration of prostate cancer digital histology and in-vivo multiparametric magnetic resonance imaging (mpMRI) image sets for clinical usefulness. A software platform was developed to achieve 3D co-registration. This software was prospectively applied to three patients who underwent radical prostatectomy. Data comprised in-vivo mpMRI [T2-weighted, dynamic contrast-enhanced weighted images (DCE); apparent diffusion coefficient (ADC)], ex-vivo T2-weighted imaging, 3D-rebuilt pathological specimen, and digital histology. Internal landmarks from zonal anatomy served as reference points for assessing co-registration accuracy and precision. Applying a method of deformable transformation based on 22 internal landmarks, a 1.6 mm accuracy was reached to align T2-weighted images and the 3D-rebuilt pathological specimen, an improvement over rigid transformation of 32% (p = 0.003). The 22 zonal anatomy landmarks were more accurately mapped using deformable transformation than rigid transformation (p = 0.0008). An automatic method based on mutual information, enabled automation of the process and to include perfusion and diffusion MRI images. Evaluation of co-registration accuracy using the volume overlap index (Dice index) met clinically relevant requirements, ranging from 0.81-0.96 for sequences tested. Ex-vivo images of the specimen did not significantly improve co-registration accuracy. This preliminary analysis suggests that deformable transformation based on zonal anatomy landmarks is accurate in the co-registration of mpMRI and histology. Including diffusion and perfusion sequences in the same 3D space as histology is essential further clinical information. The ability to localize cancer in 3D space may improve targeting for image-guided biopsy, focal therapy, and disease quantification in surveillance protocols. Copyright © 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

An assessment of interspecific competition between two introduced parasitoids of Diaphorina citri (Hemiptera: Liviidae) on caged citrus plants.

PubMed

Vankosky, Meghan A; Hoddle, Mark S

2017-06-07

Two parasitoids attacking nymphs of Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), Tamarixia radiata (Waterston) (Hymenoptera: Eulophidae) and Diaphorencyrtus aligarhensis (Shafee, Alam & Agarwal) (Hymenoptera: Encyrtidae) are being released in California, USA in a classical biological control program. To evaluate the effect of multiple parasitoid species on D. citri mortality, we conducted mesocosm experiments under controlled conditions using a complete block design with 6 treatments (D. citri nymphs exposed to: no parasitoids; D. aligarhensis or T. radiata alone; D. aligarhensis or T. radiata released first (by 48 h); and both species released simultaneously). Parasitism of D. citri nymphs by T. radiata exceeded 60% and was unchanged when D. aligarhensis were present. Parasitism by D. aligarhensis was greatest when T. radiata was absent (∼28%) and was reduced in all treatments with T. radiata present (<3%). D. citri mortality and parasitoid-related mortality of D. citri was consistent across parasitoid treatments. Laboratory results suggest that competition between D. aligarhensis and T. radiata is asymmetric and favors T. radiata. It may be difficult for D. aligarhensis to contribute significantly to D. citri biological control where T. radiata is present. However, results reported here suggest that competition between T. radiata and D. aligarhensis is not likely to reduce parasitism by T. radiata or reduce parasitoid-induced mortality of D. citri. © 2017 Institute of Zoology, Chinese Academy of Sciences.

Efficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy.

PubMed

Delanaye, Pierre; Cavalier, Etienne; Fafin, Coraline; Dubois, Bernard E; Krzesinski, Jean-Marie; Moranne, Olivier

2016-02-01

Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m(2) and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14-36), 23 (17-31), 31 (22-38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28-44), 35 (29-41), 39 (32-47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/mL. In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D.

Dose-Response Relationship between Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Regression Analysis of Prospective Cohort Studies.

PubMed

Fang, Xin; Han, Hedong; Li, Mei; Liang, Chun; Fan, Zhongjie; Aaseth, Jan; He, Jia; Montgomery, Scott; Cao, Yang

2016-11-19

The epidemiological evidence for a dose-response relationship between magnesium intake and risk of type 2 diabetes mellitus (T2D) is sparse. The aim of the study was to summarize the evidence for the association of dietary magnesium intake with risk of T2D and evaluate the dose-response relationship. We conducted a systematic review and meta-analysis of prospective cohort studies that reported dietary magnesium intake and risk of incident T2D. We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to February 2016. We included cohort studies that provided risk ratios, i.e., relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs), for T2D. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines. A total of 25 studies met the eligibility criteria. These studies comprised 637,922 individuals including 26,828 with a T2D diagnosis. Compared with the lowest magnesium consumption group in the population, the risk of T2D was reduced by 17% across all the studies; 19% in women and 16% in men. A statistically significant linear dose-response relationship was found between incremental magnesium intake and T2D risk. After adjusting for age and body mass index, the risk of T2D incidence was reduced by 8%-13% for per 100 mg/day increment in dietary magnesium intake. There was no evidence to support a nonlinear dose-response relationship between dietary magnesium intake and T2D risk. The combined data supports a role for magnesium in reducing risk of T2D, with a statistically significant linear dose-response pattern within the reference dose range of dietary intake among Asian and US populations. The evidence from Europe and black people is limited and more prospective studies are needed for the two subgroups.

User Feedback Procedures; Part III of Scientific Report No. ISR-18, Information Storage and Retrieval...

ERIC Educational Resources Information Center

Cornell Univ., Ithaca, NY. Dept. of Computer Science.

Part Three of this five part report on Salton's Magical Automatic Retriever of Texts (SMART) project contains four papers. The first: "Variations on the Query Splitting Technique with Relevance Feedback" by T. P. Baker discusses some experiments in relevance feedback performed with variations on the technique of query splitting. The…

A Qualitative Study of Confusing Experiences among Japanese Adult Patients with Type 1 Diabetes

PubMed Central

Nishio, Ikuko; Chujo, Masami; Kataoka, Hideyuki

2016-01-01

Background In this study, we investigated the powerlessness of patients with type 1 diabetes (T1D), and described the structure of powerlessness that these individuals experienced. In order for patients to recover from this state, we recommend that they take steps to regain their power. Methods Fifteen Japanese adults with T1D participated in this study. Data were collected from all subjects between July 2013 and March 2014 via in-depth semi-structured interviews. Qualitative data analysis was conducted according to a grounded theory approach. Finally, the core category was identified, which allowed us to build a new powerlessness structure for T1D. Results The results suggested a core category, ‘Wandering a tangled path,’ comprising four categories, eight subcategories, and twenty-six concepts. These four categories were as follows: ‘being burdened by T1D,’ ‘suffering from insulin-related troubles,’ ‘being unable to cope with difficulties in self-management,’ and ‘facing social prejudice.’ In the state of powerlessness, negative emotional experiences snowballed, with patients feeling more and more depressed until they ultimately reached ‘rock bottom.’ Conclusion We found that as negative emotional experiences related to powerlessness increased, negative feelings intensified until the patients reached rock bottom. Powerlessness is like ‘wandering a tangled path,’ a state in which T1D patients struggle to cope with reality on their own when faced with both internal and external events. ‘Wandering a tangled path’ is at the core of powerlessness. A primary characteristic of the structure of powerlessness is suffering from confusing experiences. To help patients cope with T1D without being crushed by powerlessness, nurses must pay attention to signs of powerlessness. Powerlessness is not just an emotional state, but a combination of feelings, perceptions, and thoughts; therefore, it is important to comprehensively understand patients’ narratives. PMID:27046954

Inelastic Proton Scattering on 21Na in Inverse Kinematics

NASA Astrophysics Data System (ADS)

Austin, Roby

2009-10-01

R.A.E. Austin, R. Kanungo, S. Reeve, Saint Mary's University; D.G. Jenkins, C.Aa.Diget, A. Robinson, A.G. Tuff, O. Roberts, University of York, UK; P.J. Woods, T. Davinson, G. J. Lotay, University of Edinburgh; C.-Y. Wu, Lawrence Livermore National Laboratory; H. Al Falou, G.C. Ball, M. Djongolov, A. Garnsworthy, G. Hackman, J.N. Orce, C.J. Pearson, S. Triambak, S.J. Williams, TRIUMF; C. Andreiou, D.S. Cross, N. Galinski, R. Kshetri, Simon Fraser University; C. Sumithrarachchi, M.A. Schumaker, University of Guelph; M.P. Jones, S.V. Rigby, University of Liverpool; D. Cline, A. Hayes, University of Rochester; T.E. Drake, University of Toronto; We describe an experiment and associated technique [1] to measure resonances of interest in astrophysical reactions. At the TRIUMF ISAC-II radioactive beam accelerator facility in Canada, particles inelastically scattered in inverse kinematics are detected with Bambino, a δE-E silicon telescope spanning 15-40 degrees in the lab. We use the TIGRESS to detect gamma rays in coincidence with the charged particles to cleanly select inelastic scattering events. We measured resonances above the alpha threshold in ^22Mg of relevance to the rate of break-out from the hot-CNO cycle via the reaction ^ 18Ne(α,p)^21Na. [1] PJ Woods et al. Rex-ISOLDE proposal 424 Cern (2003).

A. Sakharov and Fusion Research

NASA Astrophysics Data System (ADS)

Coppi, Bruno

2012-02-01

In the landmark paper by Tamm and Sakharov [1], a controlled nuclear fusion reactor based on an axisymmetric magnetic confinement configuration whose principles remain valid to this day, was proposed. In the light of present understanding of plasma physics the virtues (e.g. that of considering the D-D reaction) and the shortcomings of this paper are pointed out. In fact, relatively recent results of theoretical plasma physics (e.g. discovery of the so called second stability region) and advances in high field magnet technology have made it possible to identify the parameters of meaningful experiments capable of exploring D-D and D-^3He burn conditions. At the same time an experimental program (IGNIR) has been undertaken through a (funded) collaboration between Italy and Russia to investigate D-T plasmas close to ignition conditions based on an advanced high field toroidal confinement configuration. A. Sakharov envisioned a bolder approach to fusion research than that advocated by some of his contemporaries. The time taken to design and decide to fabricate the first experiment capable of reaching ignition conditions is due in part to the problem of gaining an adequate understanding the expected physics of fusion burning plasmas. However, most of the relevant financial effort has gone in the pursuit of slow and indirect enterprises complying with the ``playing it safe'' tendencies of large organizations or motivated by the purpose to develop technologies or maintain a high level of expertise in plasma physics to the expected benefit of other kinds of endeavors. The creativity demonstrated by A. Sakharov in dealing with civil rights and disarmament issues is needed, while maintaining our concerns for energy and the environment on a global scale, to orient the funding for fusion research toward a direct and well based scientific effort on concepts for which a variety of developments can be envisioned. These can span from uncovering new physics relevant, for instance, to high energy astrophysics to the feasibility of new neutron sources.[4pt] [1] A. Sakharov, Collected Scientific Works (Publ. Marcel Dekkes, Inc., New York, N.Y., 1982).

Quantifying the roles of random motility and directed motility using advection-diffusion theory for a 3T3 fibroblast cell migration assay stimulated with an electric field.

PubMed

Simpson, Matthew J; Lo, Kai-Yin; Sun, Yung-Shin

2017-03-17

Directed cell migration can be driven by a range of external stimuli, such as spatial gradients of: chemical signals (chemotaxis); adhesion sites (haptotaxis); or temperature (thermotaxis). Continuum models of cell migration typically include a diffusion term to capture the undirected component of cell motility and an advection term to capture the directed component of cell motility. However, there is no consensus in the literature about the form that the advection term takes. Some theoretical studies suggest that the advection term ought to include receptor saturation effects. However, others adopt a much simpler constant coefficient. One of the limitations of including receptor saturation effects is that it introduces several additional unknown parameters into the model. Therefore, a relevant research question is to investigate whether directed cell migration is best described by a simple constant tactic coefficient or a more complicated model incorporating saturation effects. We study directed cell migration using an experimental device in which the directed component of the cell motility is driven by a spatial gradient of electric potential, which is known as electrotaxis. The electric field (EF) is proportional to the spatial gradient of the electric potential. The spatial variation of electric potential across the experimental device varies in such a way that there are several subregions on the device in which the EF takes on different values that are approximately constant within those subregions. We use cell trajectory data to quantify the motion of 3T3 fibroblast cells at different locations on the device to examine how different values of the EF influences cell motility. The undirected (random) motility of the cells is quantified in terms of the cell diffusivity, D, and the directed motility is quantified in terms of a cell drift velocity, v. Estimates D and v are obtained under a range of four different EF conditions, which correspond to normal physiological conditions. Our results suggest that there is no anisotropy in D, and that D appears to be approximately independent of the EF and the electric potential. The drift velocity increases approximately linearly with the EF, suggesting that the simplest linear advection term, with no additional saturation parameters, provides a good explanation of these physiologically relevant data. We find that the simplest linear advection term in a continuum model of directed cell motility is sufficient to describe a range of different electrotaxis experiments for 3T3 fibroblast cells subject to normal physiological values of the electric field. This is useful information because alternative models that include saturation effects involve additional parameters that need to be estimated before a partial differential equation model can be applied to interpret or predict a cell migration experiment.

Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis.

PubMed

Abdel-Motal, Ussama M; G, Akila; Abdelalim, Essam M; Ponnuraja, Chinnaiyan; Iken, Khadija; Jahromi, Mohamed; Doss, George Priya; El Bekay, Rajaa; Zayed, Hatem

2018-05-17

The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D. Copyright © 2018 John Wiley & Sons, Ltd.

TacSat-4 COMMx, Advanced SATCOM Experiment

DTIC Science & Technology

2009-01-01

Schein, M. T. Marley, C. T. Apland, R. E. Lee, B. D . Williams, E. D . Schaefer, S. R. Vernon, P . D . Schwartz , B. L. Kantsiper, E. J. Finnegan;The...Lee, B. D . Williams, E. D . Schaefer, P . D . Schwartz, R. Denissen, B. Kantsiper, E. J. Finnegan; The Johns Hopkins University Applied Physics...Mission Ops Lead, NRL Code 8233 Bob Kuzma, TacSat-4 Payload Controller, NRL Code 8242 Bob Skalitzky, TacSat-4 Power Systems, NRL Code 8244 Doug Bentz

3D printing of biomimetic microstructures for cancer cell migration.

PubMed

Huang, Tina Qing; Qu, Xin; Liu, Justin; Chen, Shaochen

2014-02-01

To understand the physical behavior and migration of cancer cells, a 3D in vitro micro-chip in hydrogel was created using 3D projection printing. The micro-chip has a honeycomb branched structure, aiming to mimic 3D vascular morphology to test, monitor, and analyze differences in the behavior of cancer cells (i.e. HeLa) vs. non-cancerous cell lines (i.e. 10 T1/2). The 3D Projection Printing system can fabricate complex structures in seconds from user-created designs. The fabricated microstructures have three different channel widths of 25, 45, and 120 microns wide to reflect a range of blood vessel diameters. HeLa and 10 T1/2 cells seeded within the micro-chip were then analyzed for morphology and cell migration speed. 10 T1/2 cells exhibited greater changes in morphology due to channel size width than HeLa cells; however, channel width had a limited effect on 10 T1/2 cell migration while HeLa cancer cell migration increased as channel width decreased. This physiologically relevant 3D cancer tissue model has the potential to be a powerful tool for future drug discoveries and cancer migration studies.

Search for CP violation in singly Cabibbo suppressed four-body D decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martinelli, Maurizio

2011-02-01

We search for CP violation in a sample of 4.7 x 10 4 singly Cabibbo suppressed D 0 → K + K - π +π - decays and 1.8(2.6) x 10 4 D (s) + → K S 0 K + π + π - decays. CP violation is searched for in the difference between the T-odd asymmetries, obtained using triple product correlations, measured for D and D decays. The measured CP violation parameters are A T(D 0) = (1.0 ± 5.1(stat) ± 4.4(syst)) x 10 -3, A T(D +) = (-11.96 ± 10.04(stat) ± 4.81(syst)) x 10 -3 andmore » A T(D s +) = (-13.57 ± 7.67(stat) ± 4.82(syst)) x 10 -3. This search for CP violation showed that the T-odd correlations are a powerful tool to measure the CP violating observable A T. The relative simplicity of an analysis based on T-odd correlations and the high quality results that can be obtained, allow to consider this tool as fundamental to search for CP violation in four-body decays. Even if the CP violation has not been found, excluding any New Physics effect to the sensitivity of about 0.5%, it is still worth to search for CP violation in D decays. The high statistics that can be obtained at the LHC or by the proposed high luminosity B-factories, make this topic to be considered in high consideration by experiments such as LHCb, SuperB or SuperBelle. The results outlined in this thesis strongly suggest to include a similar analysis into the Physics program of these experiments.« less

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.

PubMed

Mercader, Josep M; Liao, Rachel G; Bell, Avery D; Dymek, Zachary; Estrada, Karol; Tukiainen, Taru; Huerta-Chagoya, Alicia; Moreno-Macías, Hortensia; Jablonski, Kathleen A; Hanson, Robert L; Walford, Geoffrey A; Moran, Ignasi; Chen, Ling; Agarwala, Vineeta; Ordoñez-Sánchez, María Luisa; Rodríguez-Guillen, Rosario; Rodríguez-Torres, Maribel; Segura-Kato, Yayoi; García-Ortiz, Humberto; Centeno-Cruz, Federico; Barajas-Olmos, Francisco; Caulkins, Lizz; Puppala, Sobha; Fontanillas, Pierre; Williams, Amy L; Bonàs-Guarch, Sílvia; Hartl, Chris; Ripke, Stephan; Tooley, Katherine; Lane, Jacqueline; Zerrweck, Carlos; Martínez-Hernández, Angélica; Córdova, Emilio J; Mendoza-Caamal, Elvia; Contreras-Cubas, Cecilia; González-Villalpando, María E; Cruz-Bautista, Ivette; Muñoz-Hernández, Liliana; Gómez-Velasco, Donaji; Alvirde, Ulises; Henderson, Brian E; Wilkens, Lynne R; Le Marchand, Loic; Arellano-Campos, Olimpia; Riba, Laura; Harden, Maegan; Gabriel, Stacey; Abboud, Hanna E; Cortes, Maria L; Revilla-Monsalve, Cristina; Islas-Andrade, Sergio; Soberon, Xavier; Curran, Joanne E; Jenkinson, Christopher P; DeFronzo, Ralph A; Lehman, Donna M; Hanis, Craig L; Bell, Graeme I; Boehnke, Michael; Blangero, John; Duggirala, Ravindranath; Saxena, Richa; MacArthur, Daniel; Ferrer, Jorge; McCarroll, Steven A; Torrents, David; Knowler, William C; Baier, Leslie J; Burtt, Noel; González-Villalpando, Clicerio; Haiman, Christopher A; Aguilar-Salinas, Carlos A; Tusié-Luna, Teresa; Flannick, Jason; Jacobs, Suzanne B R; Orozco, Lorena; Altshuler, David; Florez, Jose C

2017-11-01

Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2D and 12,966 individuals without T2D of Latino descent. We identified a novel genetic variant in the IGF2 gene associated with ∼20% reduced risk for T2D. This variant, which has an allele frequency of 17% in the Mexican population but is rare in Europe, prevents splicing between IGF2 exons 1 and 2. We show in vitro and in human liver and adipose tissue that the variant is associated with a specific, allele-dosage-dependent reduction in the expression of IGF2 isoform 2. In individuals who do not carry the protective allele, expression of IGF2 isoform 2 in adipose is positively correlated with both incidence of T2D and increased plasma glycated hemoglobin in individuals without T2D, providing support that the protective effects are mediated by reductions in IGF2 isoform 2. Broad phenotypic examination of carriers of the protective variant revealed no association with other disease states or impaired reproductive health. These findings suggest that reducing IGF2 isoform 2 expression in relevant tissues has potential as a new therapeutic strategy for T2D, even beyond the Latin American population, with no major adverse effects on health or reproduction. © 2017 by the American Diabetes Association.

Change in circulating microRNA profile of obese children indicates future risk of adult diabetes.

PubMed

Cui, Xianwei; You, Lianghui; Zhu, Lijun; Wang, Xing; Zhou, Yahui; Li, Yun; Wen, Juan; Xia, Yankai; Wang, Xinru; Ji, Chenbo; Guo, Xirong

2018-01-01

Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic biomarkers, and they may contribute to the progression toward T2D. Here, we investigated the possibility of predicting the future risk of adult T2D in obese children by using circulating miRNAs. We performed miRNA high-throughput sequencing to screen relevant circulating miRNAs in obese children. The expression patterns of targeted miRNAs were further explored in obese children and adults with T2D. To investigate the underlying contributions of these miRNAs to the development of T2D, we detected the impacts of the candidate miRNAs on preadipocyte proliferation, insulin secretion by pancreatic β-cell, and glucose uptake by skeletal muscle cells. Three miRNAs (miR-486, miR-146b and miR-15b), whose expression in the circulation was most dramatically augmented in obese children and adult T2D patients, were selected for further investigation. Of these 3 miRNAs, miR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obesity and T2D. Our results provide a better understanding of the role of circulating miRNAs, particularly miR-486, miR-146b and miR-15b, in predicting the future risk of T2D in obese children. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Interferometric measurement of the temperature dependence of an index of refraction: application to fused silica.

PubMed

Dupouy, Paul-Edouard; Büchner, Matthias; Paquier, Philippe; Trénec, Gérard; Vigué, Jacques

2010-02-01

The light reflected by an uncoated Fabry-Perot etalon presents dark rings which give a very sensitive measurement of the variations of the return optical path in the etalon. By measuring the diameters of these rings as a function of the etalon temperature T, we get a sensitive measurement of the derivative dn/dT of the index of refraction n. We have made this experiment with a fused silica etalon and we have achieved a 2% relative uncertainty on dn/dT, comparable to the uncertainty of the best experiments.

Retaining both discrete and smooth features in 1D and 2D NMR relaxation and diffusion experiments

NASA Astrophysics Data System (ADS)

Reci, A.; Sederman, A. J.; Gladden, L. F.

2017-11-01

A new method of regularization of 1D and 2D NMR relaxation and diffusion experiments is proposed and a robust algorithm for its implementation is introduced. The new form of regularization, termed the Modified Total Generalized Variation (MTGV) regularization, offers a compromise between distinguishing discrete and smooth features in the reconstructed distributions. The method is compared to the conventional method of Tikhonov regularization and the recently proposed method of L1 regularization, when applied to simulated data of 1D spin-lattice relaxation, T1, 1D spin-spin relaxation, T2, and 2D T1-T2 NMR experiments. A range of simulated distributions composed of two lognormally distributed peaks were studied. The distributions differed with regard to the variance of the peaks, which were designed to investigate a range of distributions containing only discrete, only smooth or both features in the same distribution. Three different signal-to-noise ratios were studied: 2000, 200 and 20. A new metric is proposed to compare the distributions reconstructed from the different regularization methods with the true distributions. The metric is designed to penalise reconstructed distributions which show artefact peaks. Based on this metric, MTGV regularization performs better than Tikhonov and L1 regularization in all cases except when the distribution is known to only comprise of discrete peaks, in which case L1 regularization is slightly more accurate than MTGV regularization.

Experimental investigation of stability, frequency and toroidal mode number of compressional Alfvén eigenmodes in DIII-D

NASA Astrophysics Data System (ADS)

Tang, S.; Thome, K.; Pace, D.; Heidbrink, W. W.; Carter, T. A.; Crocker, N. A.; NSTX-U Collaboration; DIII-D Collaboration

2017-10-01

An experimental investigation of the stability of Doppler-shifted cyclotron resonant compressional Alfvén eigenmodes (CAE) using the flexible DIII-D neutral beams has begun to validate a theoretical understanding and realize the CAE's diagnostic potential. CAEs are excited by energetic ions from neutral beams [Heidbrink, NF 2006], with frequencies and toroidal mode numbers sensitive to the fast-ion phase space distribution, making them a potentially powerful passive diagnostic. The experiment also contributes to a predictive capability for spherical tokamak temperature profiles, where CAEs may play a role in energy transport [Crocker, NF 2013]. CAE activity was observed using the recently developed Ion Cyclotron Emission diagnostic-high bandwidth edge magnetic sensors sampled at 200 MS/s. Preliminary results show CAEs become unstable in BT ramp discharges below a critical threshold in the range 1.7 - 1.9 T, with the exact value increasing as density increases. The experiment will be used to validate simulations from relevant codes such as the Hybrid MHD code [Belova, PRL 2015]. This work was supported by US DOE Grants DE-SC0011810 and DE-FC02-04ER54698.

D-Xylose fermentation, xylitol production and xylanase activities by seven new species of Sugiyamaella.

PubMed

Sena, Letícia M F; Morais, Camila G; Lopes, Mariana R; Santos, Renata O; Uetanabaro, Ana P T; Morais, Paula B; Vital, Marcos J S; de Morais, Marcos A; Lachance, Marc-André; Rosa, Carlos A

2017-01-01

Sixteen yeast isolates identified as belonging to the genus Sugiyamaella were studied in relation to D-xylose fermentation, xylitol production, and xylanase activities. The yeasts were recovered from rotting wood and sugarcane bagasse samples in different Brazilian regions. Sequence analyses of the internal transcribed spacer (ITS) region and the D1/D2 domains of large subunit rRNA gene showed that these isolates belong to seven new species. The species are described here as Sugiyamaella ayubii f.a., sp. nov. (UFMG-CM-Y607 T  = CBS 14108 T ), Sugiyamaella bahiana f.a., sp. nov. (UFMG-CM-Y304 T  = CBS 13474 T ), Sugiyamaella bonitensis f.a., sp. nov. (UFMG-CM-Y608 T  = CBS 14270 T ), Sugiyamaella carassensis f.a., sp. nov. (UFMG-CM-Y606 T  = CBS 14107 T ), Sugiyamaella ligni f.a., sp. nov. (UFMG-CM-Y295 T  = CBS 13482 T ), Sugiyamaella valenteae f.a., sp. nov. (UFMG-CM-Y609 T  = CBS 14109 T ) and Sugiyamaella xylolytica f.a., sp. nov. (UFMG-CM-Y348 T  = CBS 13493 T ). Strains of the described species S. boreocaroliniensis, S. lignohabitans, S. novakii and S. xylanicola, isolated from rotting wood of Brazilian ecosystems, were also compared for traits relevant to xylose metabolism. S. valenteae sp. nov., S. xylolytica sp. nov., S. bahiana sp. nov., S. bonitensis sp. nov., S. boreocarolinensis, S. lignohabitans and S. xylanicola were able to ferment D-xylose to ethanol. Xylitol production was observed for all Sugiyamaella species studied, except for S. ayubii sp. nov. All species studied showed xylanolytic activity, with S. xylanicola, S. lignohabitans and S. valenteae sp. nov. having the highest values. Our results suggest these Sugiyamaella species have good potential for biotechnological applications.

Human Behaviour in High Stress Situations in Aerospace Operations Conference Proceedings Held in The Hague, The Netherlands on 24-28 October 1988

DTIC Science & Technology

1989-06-01

Continuously stimulating advances in the aerospace sciences relevant to strengthening the common defence posture; - Improving the co-operation among member...very stimulating symposium. vii KI-1 PREDICTION OF PERSONALITY Harald T. Andersen M.D., Ph.D., D.Sc,D.Av.Med. Director RNoAF Institute of Aviation...audio tape recorder which was connected to the aircraft communication system. This recorder provided a continuous auditory record of each mission so that

Multi-Rocket Thought Experiment

NASA Astrophysics Data System (ADS)

Smarandache, Florentin

2014-03-01

We consider n>=2 identical rockets: R1 ,R2 , ..., Rn. Each of them moving at constant different velocities respectively v1 ,v2 , ..., vn on parallel directions in the same sense. In each rocket there is a light clock, the observer on earth also has a light clock. All n + 1 light clocks are identical and synchronized. The proper time Δt' in each rocket is the same. (1) If we consider the observer on earth and the first rocket R1, then the non-proper time Δt of the observer on earth is dilated with the factor D(v1) : or Δt = Δt' D(v1) (1) But if we consider the observer on earth and the second rocket R2 , then the non-proper time Δt of the observer on earth is dilated with a different factor D(v2) : or Δt = Δt' D(v2) And so on. Therefore simultaneously Δt is dilated with different factors D(v1) , D(v2), ..., D(vn) , which is a multiple contradiction.

Phase competition and anomalous thermal evolution in high-temperature superconductors

NASA Astrophysics Data System (ADS)

Yu, Zuo-Dong; Zhou, Yuan; Yin, Wei-Guo; Lin, Hai-Qing; Gong, Chang-De

2017-07-01

The interplay of competing orders is relevant to high-temperature superconductivity known to emerge upon suppression of a parent antiferromagnetic order typically via charge doping. How such interplay evolves at low temperature—in particular at what doping level the zero-temperature quantum critical point (QCP) is located—is still elusive because it is masked by the superconducting state. The QCP had long been believed to follow a smooth extrapolation of the characteristic temperature T* for the strange normal state well above the superconducting transition temperature. However, recently the T* within the superconducting dome was reported to unexpectedly exhibit back-bending likely in the cuprate Bi2Sr2CaCu2O8 +δ . Here we show that the original and revised phase diagrams can be understood in terms of weak and moderate competitions, respectively, between superconductivity and a pseudogap state such as d -density or spin-density wave, based on both Ginzburg-Landau theory and the realistic t -t'-t''-J -V model for the cuprates. We further found that the calculated temperature and doping-level dependence of the quasiparticle spectral gap and Raman response qualitatively agrees with the experiments. In particular, the T* back-bending can provide a simple explanation of the observed anomalous two-step thermal evolution dominated by the superconducting gap and the pseudogap, respectively. Our results imply that the revised phase diagram is likely to take place in high-temperature superconductors.

Thyroid hormone deiodinases D1, D2, and D3 are expressed in human endothelial dermal microvascular line: effects of thyroid hormones.

PubMed

Sabatino, Laura; Lubrano, Valter; Balzan, Silvana; Kusmic, Claudia; Del Turco, Serena; Iervasi, Giorgio

2015-01-01

Endothelial system acts as a large endocrine organ in the human body; however, little is still known about the regulative role of THs on endothelial cells. Aim of the present study was to investigate the expression of the TH deiodinases (D1, D2, and D3) and TH receptors (TRα1, TRα2, and TRβ1) in an endothelial microvascular cultured cell model (HMEC-1), after stimulation with triiodothyronine (T3, 10-100 nM), thyroxine (T4, 10-100 nM), and reverse T3 (rT3, 1-10 nM). DIO1 was significantly inhibited by T4 at 10 and 100 nM (p < 0.001). rT3 significantly inhibited DIO1 at 1 nM concentration (p < 0.01) and stimulated DIO1 at 10 nM dosage (p < 0.001). T4 and rT3 significantly inhibited DIO2 at all concentrations. DIO3 was induced at 100 nM T3 (p < 0.05) and 100 nM rT3 (p < 0.01), and TRα1 and TRα2 mRNAs were significantly increased after 100 nM T3 treatment (p < 0.05) and decreased after 1 and 10 nM rT3 (p < 0.05). TRβ1 was significantly increased by all THs at different concentrations: 10 nM T3 and 100 nM T3 (p < 0.05), 1 nM rT3 (p < 0.001), and 100 nM T4 (p < 0.01). D1 and D2 protein levels were evaluated, but no significant difference was observed for any hormonal treatment. For the first time, we found that the TH deiodinases and receptors are expressed in endothelial HMEC-1 cells. These findings might be of significant clinical relevance, given the important regulatory role of the endothelium as first barrier to the bloodstream.

Technique for Forming Solid D2 and D-T Layers for Shock Timing Experiments at the National Ignition Facility

DOE PAGES

Sater, J. D.; Espinosa-Loza, F.; Kozioziemski, B.; ...

2016-07-11

Capsule implosion experiments on the National Ignition Facility (NIF) are driven with a carefully tailored laser pulse that delivers a sequence of shocks to the ablator and fuel. In order to ensure the shocks converge at the desired position, the shock strength and velocity are measured in experimental platforms referred to as keyhole targets. We made shock measurements on capsules completely filled with liquid deuterium for the solid deuterium tritide (D-T) layer campaigns. Modeling has been used to extend these results to form an estimate of the shock properties in solid D-T layers. Furthermore, to verify and improve the surrogacymore » of the liquid-filled keyhole measurements, we have developed a technique to form a solid layer inside the keyhole capsule. The layer is typically uniform over a 400-μm-diameter area. This is sufficient to allow direct measurement of the shock velocity. This layering technique has been successfully applied to 13 experiments on the NIF. The technique may also be applicable to fast-igniter experiments since some proposed designs resemble keyhole targets. We discuss our method in detail and give representative results.« less

T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice

PubMed Central

Clarkson, Benjamin D.S.; Ling, Changying; Shi, Yejie; Harris, Melissa G.; Rayasam, Aditya; Sun, Dandan; Salamat, M. Shahriar; Kuchroo, Vijay; Lambris, John D.; Sandor, Matyas

2014-01-01

T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. IL-21–deficient mice have smaller infarcts, improved neurological function, and reduced lymphocyte accumulation in the brain within 24 h of reperfusion. Intracellular cytokine staining and adoptive transfer experiments revealed that brain-infiltrating CD4+ T cells are the predominant IL-21 source. Mice treated with decoy IL-21 receptor Fc fusion protein are protected from reperfusion injury. In postmortem human brain tissue, IL-21 localized to perivascular CD4+ T cells in the area surrounding acute stroke lesions, suggesting that IL-21–mediated brain injury may be relevant to human stroke. PMID:24616379

T.Rex

DOE Office of Scientific and Technical Information (OSTI.GOV)

2016-06-08

T.Rex is used to explore tabular data sets containing up to ten million records to help rapidly understand a previously unknown data set. Analysis can quickly identify patterns of interest and the records and fields that capture those patterns. T.Rex contains a growing set of deep analytical tools and supports robust export capabilities that selected data can be incorporated into to other specialized tools for further analysis. T.Rex is flexible in ingesting different types and formats of data, allowing the user to interactively experiment and perform trial and error guesses on the structure of the data; and also has amore » variety of linked visual analytic tools that enable exploration of the data to find relevant content, relationships among content, trends within the content, and capture knowledge about the content. Finally, T.Rex has a rich export capability, to extract relevant subsets of a larger data source, to further analyze their data in other analytic tools.« less

Situational Awareness and Communication Experiment for Military Operations in Urban Terrain: Experiment 1

DTIC Science & Technology

2001-10-01

CO (N tN IN ^ j co co co in in T-l (A \\ D ^o o o eg z <Z \\0 IN i-i o co oo I D co c o z <Z in es co ■>* IN...NATL LAB ENGNRNG MECHANICS DEPT MS 9042 ATTN J HANDROCK YRKAN JLAUFFER PO BOX 969 LIVERMORE CA 94551-0969 US ARMY RSCHINST ATTN PERI IK D L...would be included in the AC. Van Cott and Paramore (1988) defined a task as a goal- directed behavior. Since the purpose was to develop an AC for

High-intensity interval training for improving postprandial hyperglycemia.

PubMed

Little, Jonathan P; Francois, Monique E

2014-12-01

High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings have clinical relevance because elevated postprandial hyperglycemia is a significant risk factor for cardiovascular morbidity and mortality. This article summarizes the latest evidence demonstrating that HIIT can improve postprandial glucose control to highlight the potential application of HIIT in the prevention and management of T2D and associated cardiovascular complications.

Changes in NMR relaxation times of adjacent muscle after implantation of malignant and normal tissue.

PubMed Central

Ling, C. R.; Foster, M. A.; Mallard, J. R.

1979-01-01

In separate experiments, normal foreign tissue and malignant tumour were implanted s.c. into the rat thigh. NMR T1 values of the adjacent normal muscle, resulting from local inflammatory reactions or from malignant invasion, were measured. Elevations in T1 of the underlying muscle occurred within 24 h in both experiments, and it is believed these were caused by rapid inflammatory and immunological reactions to the implants. However the T1 values of muscle samples adjacent to the non-malignant implants decreased during the 11 days after implantation, dropping to values within the normal range. In the second experiment there was progressive malignant invasion into the normal adjacent tissue and the elevated T1 values were maintained throughout the 12-day period. The effects of the implantation on tissue water content are discussed in relation to NMR T1 relaxation times, and the relevance to whole-body NMR imaging of elevated T1 values due to nonmalignant pathological states is considered. PMID:526431

Nitrate induces a type 1 diabetic profile in alligator hatchlings.

PubMed

Edwards, Thea M; Hamlin, Heather J; Freymiller, Haley; Green, Stephen; Thurman, Jenna; Guillette, Louis J

2018-01-01

Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology. One potential factor, supported primarily by epidemiological studies, is the presence of nitrate and nitrite in drinking water. To test this hypothesis, female hatchling alligators were exposed to environmentally relevant concentrations of nitrate in their tank water (reference, 10mg/L, or 100mg/L NO 3 -N) from hatch through 5 weeks or 5 months of age. At each time point, endpoints related to T1D were investigated: plasma levels of glucose, triglycerides, testosterone, estradiol, and thyroxine; pancreas, fat body, and thyroid weights; weight gain or loss; presence of immune cells in the pancreas; and pancreatic beta cell number, assessed by antibody staining of nkx6.1 protein. Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin. Cluster analysis indicated that high nitrate exposure (most animals exposed to 100mg/L NO3-N and one alligator exposed to 10mg/L NO3-N) induced a profile of endpoints consistent with early T1D that could be detected after 5 weeks and was more strongly present after 5 months. Our study supports epidemiological data correlating elevated nitrate with T1D onset in humans, and highlights nitrate as a possible environmental contributor to the etiology of T1D, possibly through its role as a nitric oxide precursor. Copyright © 2017 Elsevier Inc. All rights reserved.

Prospects for measuring the fuel ion ratio in burning ITER plasmas using a DT neutron emission spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hellesen, C.; Skiba, M., E-mail: mateusz.skiba@physics.uu.se; Dzysiuk, N.

2014-11-15

The fuel ion ratio n{sub t}/n{sub d} is an essential parameter for plasma control in fusion reactor relevant applications, since maximum fusion power is attained when equal amounts of tritium (T) and deuterium (D) are present in the plasma, i.e., n{sub t}/n{sub d} = 1.0. For neutral beam heated plasmas, this parameter can be measured using a single neutron spectrometer, as has been shown for tritium concentrations up to 90%, using data obtained with the MPR (Magnetic Proton Recoil) spectrometer during a DT experimental campaign at the Joint European Torus in 1997. In this paper, we evaluate the demands thatmore » a DT spectrometer has to fulfill to be able to determine n{sub t}/n{sub d} with a relative error below 20%, as is required for such measurements at ITER. The assessment shows that a back-scattering time-of-flight design is a promising concept for spectroscopy of 14 MeV DT emission neutrons.« less

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

PubMed Central

Horikoshi, Momoko; Pasquali, Lorenzo; Wiltshire, Steven; Huyghe, Jeroen R.; Mahajan, Anubha; Asimit, Jennifer L.; Ferreira, Teresa; Locke, Adam E.; Robertson, Neil R.; Wang, Xu; Sim, Xueling; Fujita, Hayato; Hara, Kazuo; Young, Robin; Zhang, Weihua; Choi, Sungkyoung; Chen, Han; Kaur, Ismeet; Takeuchi, Fumihiko; Fontanillas, Pierre; Thuillier, Dorothée; Yengo, Loic; Below, Jennifer E.; Tam, Claudia H.T.; Wu, Ying; Abecasis, Gonçalo; Altshuler, David; Bell, Graeme I.; Blangero, John; Burtt, Noél P.; Duggirala, Ravindranath; Florez, Jose C.; Hanis, Craig L.; Seielstad, Mark; Atzmon, Gil; Chan, Juliana C.N.; Ma, Ronald C.W.; Froguel, Philippe; Wilson, James G.; Bharadwaj, Dwaipayan; Dupuis, Josee; Meigs, James B.; Cho, Yoon Shin; Park, Taesung; Kooner, Jaspal S.; Chambers, John C.; Saleheen, Danish; Kadowaki, Takashi; Tai, E. Shyong; Mohlke, Karen L.; Cox, Nancy J.; Ferrer, Jorge; Zeggini, Eleftheria; Kato, Norihiro; Teo, Yik Ying; Boehnke, Michael; McCarthy, Mark I.; Morris, Andrew P.

2016-01-01

To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional analyses, we identified seven distinct association signals at these four loci, each with allelic effects on T2D susceptibility that were homogenous across ancestry groups. By leveraging differences in the structure of linkage disequilibrium between diverse populations, and increased sample size, we localised the variants most likely to drive each distinct association signal. We demonstrated that integration of these genetic fine-mapping data with genomic annotation can highlight potential causal regulatory elements in T2D-relevant tissues. These analyses provide insight into the mechanisms through which T2D association signals are mediated, and suggest future routes to understanding the biology of specific disease susceptibility loci. PMID:26911676

Form and function in hillslope hydrology: in situ imaging and characterization of flow-relevant structures

NASA Astrophysics Data System (ADS)

Jackisch, Conrad; Angermann, Lisa; Allroggen, Niklas; Sprenger, Matthias; Blume, Theresa; Tronicke, Jens; Zehe, Erwin

2017-07-01

The study deals with the identification and characterization of rapid subsurface flow structures through pedo- and geo-physical measurements and irrigation experiments at the point, plot and hillslope scale. Our investigation of flow-relevant structures and hydrological responses refers to the general interplay of form and function, respectively. To obtain a holistic picture of the subsurface, a large set of different laboratory, exploratory and experimental methods was used at the different scales. For exploration these methods included drilled soil core profiles, in situ measurements of infiltration capacity and saturated hydraulic conductivity, and laboratory analyses of soil water retention and saturated hydraulic conductivity. The irrigation experiments at the plot scale were monitored through a combination of dye tracer, salt tracer, soil moisture dynamics, and 3-D time-lapse ground penetrating radar (GPR) methods. At the hillslope scale the subsurface was explored by a 3-D GPR survey. A natural storm event and an irrigation experiment were monitored by a dense network of soil moisture observations and a cascade of 2-D time-lapse GPR trenches. We show that the shift between activated and non-activated state of the flow paths is needed to distinguish structures from overall heterogeneity. Pedo-physical analyses of point-scale samples are the basis for sub-scale structure inference. At the plot and hillslope scale 3-D and 2-D time-lapse GPR applications are successfully employed as non-invasive means to image subsurface response patterns and to identify flow-relevant paths. Tracer recovery and soil water responses from irrigation experiments deliver a consistent estimate of response velocities. The combined observation of form and function under active conditions provides the means to localize and characterize the structures (this study) and the hydrological processes (companion study Angermann et al., 2017, this issue).

Equation of State and Viscosity of Tantalum and Iron from First Principles

NASA Astrophysics Data System (ADS)

Miljacic, Ljubomir; Demers, Steven; van de Walle, Axel

2011-03-01

To understand and model at continuum level the high-energy-density dynamic response in transition metals like Tantalum and Iron, as it arises in hypervelocity impact experiments, an accurate prediction of the underlying thermodynamic and kinetic properties for a range of temperatures and pressures is of critical importance. The relevant time scale of atomic motion in a dense gas, liquid, and solid is accessible with ab-initio Molecular Dynamics (MD) simulations. We calculate EoS for Ta and Fe via Thermodynamical Integration in 2D (V,T) phase space throughout different single and two-component phases. To reduce the ab-initio demand in selected regions of the space, we fit available gas-liquid data to the Peng-Robinson model and treat the solid phase within the Boxed-quasi-harmonic approximation. In the fluid part of the 2D phase space, we calculate shear viscosity via Green-Kubo relations, as time integration of the stress autocorrelation function.

STS-78 Flight Day 11

NASA Technical Reports Server (NTRS)

1996-01-01

On this eleventh day of the STS-78 mission, the flight crew, Cmdr. Terence T. Henricks, Pilot Kevin R. Kregel, Payload Cmdr. Susan J. Helms, Mission Specialists Richard M. Linnehan, Charles E. Brady, Jr., and Payload Specialists Jean-Jacques Favier, Ph.D. and Robert B. Thirsk, M.D., are shown conducting a news conference to discuss the progress of the international mission with media from the United States, Canada and Europe. During the press conference, the crew explained the relevance of the experiments conducted aboard the Life Sciences and Microgravity mission, and praised support crews and researchers on Earth who are involved in the mission. Payload Specialist Dr. Robert Thirsk told Canadian journalists of how the research will not only benefit astronauts as they conduct long-term space missions, but also people on Earth. Some of the research will aid studies on osteoporosis and the effects steroids have on bones, and also may help doctors on Earth develop treatments for muscle diseases like muscular dystrophy, Thirsk told reporters in Toronto.

Attachment Theory in Supervision: A Critical Incident Experience

ERIC Educational Resources Information Center

Pistole, M. Carole; Fitch, Jenelle C.

2008-01-01

Critical incident experiences are a powerful source of counselor development (T. M. Skovholt & P. R. McCarthy, 1988a, 1988b) and are relevant to attachment issues. An attachment theory perspective of supervision is presented and applied to a critical incident case scenario. By focusing on the behavioral systems (i.e., attachment, caregiving, and…

"Real World" Experiences Bring T and E Alive

ERIC Educational Resources Information Center

Rust, Terrie

2011-01-01

Informal education (IE) refers to activities that occur outside the school setting, and that were not primarily developed for school use or as part of a school curriculum. Informal education is an important component of the teaching of technology and engineering education, adding relevance to student experiences. The practice of informal education…

Youth and parent feelings about type 1 diabetes (T1D) management technologies

USDA-ARS?s Scientific Manuscript database

Use of T1D management technologies, including insulin pumps and continuous glucose monitors, is rapidly growing. However, research has only recently begun to evaluate youth and parent feelings about and experiences with using these technologies and the relationship with health-related quality of lif...

Wickerhamomyces tratensis sp. nov. and Candida namnaoensis sp. nov., two novel ascomycetous yeast species in the Wickerhamomyces clade found in Thailand.

PubMed

Nakase, Takashi; Jindamorakot, Sasitorn; Am-In, Somjit; Ninomiya, Shinya; Kawasaki, Hiroko

2012-01-01

Two closely related yeast strains, ST-382 and ST-392, isolated in Thailand showed intermediate relatedness in the DNA-DNA hybridization experiment suggesting that the two strains represent closely related distinct species. In the tree based on the D1/D2 domain sequences of the large subunit rRNA gene, the two strains are located in a subclade in the Wickerhamomyces clade with high bootstrap support. In the D1/D2 domain, the two strains differed by two nucleotides and are assumed to be very closely related. Strain ST-392(T) (=BCC 15102(T) = NBRC 107799(T) = CBS 12176(T) forming hat-shaped ascospores is described as Wickerhamomyces tratensis sp. nov. and strain ST-382(T) (= BCC 15093(T) = NBRC 107800(T) = CBS 12175(T) is described as Candida namnaoensis sp. nov. because ascospores are not found in this strain. In phenotypic characteristics, W. tratensis and C. namnaoensis are discriminated by the ability of alcoholic fermentation and the assimilation of galactose, D-xylose and D-gluconic acid.

Trojan Horse cross section measurements and their impact on primordial nucleosynthesis

NASA Astrophysics Data System (ADS)

Pizzone, R. G.; Spartá, R.; Bertulani, C.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Mukhamedzhanov, A.; Tumino, A.

2018-01-01

Big Bang Nucleosynthesis (BBN) nucleosynthesis requires several nuclear physics inputs and, among them, an important role is played by nuclear reaction rates. They are among the most important input for a quantitative description of the early Universe. An up-to-date compilation of direct cross sections of d(d,p)t, d(d,n)3He and 3He(d,p)4He reactions is given, being these ones among the most uncertain bare-nucleus cross sections. An intense experimental effort has been carried on in the last decade to apply the Trojan Horse Method (THM) to study reactions of relevance for the BBN and measure their astrophysical S(E)-factor. The result of these recent measurements is reviewed and compared with the available direct data. The reaction rates and the relative error for the four reactions of interest are then numerically calculated in the temperature ranges of relevance for BBN (0.01

Query Expansion for Noisy Legal Documents

DTIC Science & Technology

2008-11-01

9] G. Salton (ed). The SMART retrieval system experiments in automatic document processing. 1971. [10] H. Schutze and J . Pedersen. A cooccurrence...Language Modeling and Information Retrieval. http://www.lemurproject.org. [2] J . Baron, D. Lewis, and D. Oard. TREC 2006 legal track overview. In...Retrieval, 1993. [8] J . Rocchio. Relevance feedback in information retrieval. In The SMART retrieval system experiments in automatic document processing, 1971

Effects of different yeast cell wall supplements added to maize- or wheat-based diets for broiler chickens.

PubMed

Morales-López, R; Auclair, E; Van Immerseel, F; Ducatelle, R; García, F; Brufau, J

2010-06-01

1. Three experiments were carried out to study the effects of two experimental yeast cell wall (YCW) supplements, one from the yeast extract industry and the other from the brewery industry, added to maize or wheat based-diets, on performance and intestinal parameters of broiler chickens (Ross 308). 2. In the first and second experiments, a completely randomised block design with 4 experimental treatments was used: T-1) Negative control, no additives T-2) Positive control, avilamycin group (10 mg/kg feed), T-3) Yeast extract-YCW (500 mg/kg), and T-4) Brewery-YCW (500 mg/kg feed). There were 6 replicates of 20 (experiment 1) and 22 (experiment 2) chicks per treatment. 3. In experiment 1 (wheat based diets), yeast extract-YCW increased BW and daily feed intake (42 d). The effects were comparable to those of avilamycin. In experiment 2 (maize based diet), avilamycin, yeast extract-YCW and brewery-YCW treatments improved the feed conversion ratio with respect to the negative control group (0 to 14 d). 4. At 24 d, in both experiments, the ileal nutrient digestibility and ileal bacterial counts were not affected by any experimental treatment. In maize diets, lower intestinal viscosity was obtained with avilamycin, yeast extract-YCW and brewery-YCW than with the negative control. In wheat diets, yeast extract-YCW and brewery-YCW reduced intestinal viscosity. 5. A third experiment was conducted to study the effect of yeast extract-YCW on animal performance, intestinal mucosa morphology and intestinal viscosity. A 2 x 2 factorial arrangement of treatments was used; one factor was the dietary yeast extract-YCW supplementation (0 or 500 mg/kg feed) and the other the cereal in the diet (maize or wheat). 6. At 43 d, the heaviest BW was in chickens fed on yeast extract-YCW compared to those given the negative control. At 22 d, yeast extract-YCW increased villus height, mucus thickness and number of goblet cells with respect to negative control. 7. Results of these experiments suggest that supplementation of yeast extract-YCW to broiler chicken diets increased animal performance by favouring intestinal mucosal development.

High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: A meta-analysis.

PubMed

De Nardi, Angélica Trevisan; Tolves, Tainara; Lenzi, Thatiane Larissa; Signori, Luis Ulisses; Silva, Antônio Marcos Vargas da

2018-03-01

To compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on functional capacity and cardiometabolic markers in individuals prediabetes and type 2 diabetes (T2D). The search was performed in PubMed (MEDLINE), EMBASE, PEDro, CENTRAL, Scopus, LILACS database, and Clinical Trials from the inception to July 2017, included randomized clinical trials that compared the use of HIIT and MICT in prediabetes and T2D adults. The risk of bias was defined by Cochrane Handbook and quality of evidence by GRADE. From 818 relevant records, seven studies were included in systematic review (64 prediabetes and 120 T2D patients) and five with T2D were meta-analyzed. HIIT promoted significantly increased of 3.02 mL/kg/min (CI95% 1.42-4.61) of VO 2 max, measured for functional capacity, compared to MICT. No differences were found between two modalities of exercises considering the outcomes HbA1c, systolic and diastolic blood pressure, total cholesterol, HDL and LDL cholesterol, triglycerides, BMI, and waist-to-hip ratio. Most of the studies presented unclear risk of bias, and low and very low quality of evidence. HIIT induces cardiometabolic adaptations similar to those of MICT in prediabetes and T2D, and provides greater benefits to functional capacity in patients with T2D. CRD42016047151. Copyright © 2018 Elsevier B.V. All rights reserved.

Lifestyle and emotional well-being in men and women with type 2 diabetes (e-VitaDM-4; ZODIAC-48).

PubMed

Hendriks, Steven H; van Soldt, Evelien G W; van Vugt, Michael; Groenier, Klaas H; Roelofsen, Yvonne; Maas, Angela H E M; Bilo, Henk J G; Kleefstra, Nanne; van Hateren, Kornelis J J

2017-12-01

Whether lifestyle is associated with well-being in patients with type 2 diabetes (T2D) is largely unknown. Uncovering and clarifying associations between these constructs may lead to new strategies for improving both. The aim was to investigate the relationship between lifestyle and well-being, focussing on gender differences. This cross-sectional study included 1085 patients with T2D that participated in the e-Vita part of the Zwolle outpatient diabetes project integrating available care (ZODIAC) study. Patients were included from May 2012 until September 2014 from 52 general practices. Emotional well-being was assessed with the World Health Organization-5 well-being index (WHO-5). Lifestyle information on body mass index, smoking, physical activity and alcohol use was extracted from self-reported questionnaires. Multiple linear regression analyses were used. After adjustment for other lifestyle factors, physical activity, smoking and drinking 22-35 alcohol consumptions per week were associated with the WHO-5 score in men and physical activity and smoking were associated with the WHO-5 score in women. In the fully adjusted analyses for the total study population, physical activity and smoking were still associated with the WHO-5 score (b = 1.1, P < .001 and b =-3.1, P = .018, respectively). In the fully adjusted analyses stratified to gender only physical activity was associated with the WHO-5 score (in men: b =0.8, P = .006, in women: b = 1.4, P = .001). This study shows a negative, non-clinically relevant association between smoking and emotional well-being in the total population with T2D and a positive, non-clinically relevant association between physical activity and emotional well-being in both men and women with T2D.

Interpersonal Engagement Mediates the Relation between Maternal Affect and Externalising Behaviour in Young Children with Type 1 Diabetes

PubMed Central

Chisholm, Vivienne; Gonzalez, Andrea; Atkinson, Leslie

2014-01-01

Mother-child interactions around a shared activity have been shown to play a key role in the development of young children’s capacity to interact cooperatively with others. This evidence is particularly germane to type 1 diabetes (T1D) management in younger children where cooperation with parental treatment efforts is crucial for treatment success and where maternal distress and child behavioural problems are risk factors for treatment management, biomedical and psychological outcomes. In 49 4-to-8 year old children with T1D, we investigated whether the association between maternal affect and child problematic behaviour is mediated by mother-child interactions in the context of a T1D-relevant collaborative problem-solving activity. Mothers completed standardised measures of maternal and child psychological adjustment and interacted with their children in the problem-solving activity, analysed for quality of interpersonal engagement based on evaluations of maternal (sensitivity and cognitive stimulation) and dyadic (joint attention and warmth) behaviours. Mediation analyses confirmed the hypothesis that interpersonal engagement mediates the relation between maternal affective state and child behavioural problems. Specifically, more negative maternal affect is associated with lower levels of interpersonal engagement; these less engaged interactions in turn are associated with more behavioural problems in children. These findings are consistent with research involving typically developing children. The implications of our findings are twofold. First, in the context of psychological adjustment to T1D, maternal affect and mother-child interactions are 2 potential targets for interventions which promote cooperative interactions. Second, understanding and caring for children at biological risk requires attention to developmental psychology theory and method; in particular, research addressing parent-child cooperation carries both conceptual and clinical relevance. PMID:24905358

Rapid Parametric Mapping of the Longitudinal Relaxation Time T1 Using Two-Dimensional Variable Flip Angle Magnetic Resonance Imaging at 1.5 Tesla, 3 Tesla, and 7 Tesla

PubMed Central

Dieringer, Matthias A.; Deimling, Michael; Santoro, Davide; Wuerfel, Jens; Madai, Vince I.; Sobesky, Jan; von Knobelsdorff-Brenkenhoff, Florian; Schulz-Menger, Jeanette; Niendorf, Thoralf

2014-01-01

Introduction Visual but subjective reading of longitudinal relaxation time (T1) weighted magnetic resonance images is commonly used for the detection of brain pathologies. For this non-quantitative measure, diagnostic quality depends on hardware configuration, imaging parameters, radio frequency transmission field (B1+) uniformity, as well as observer experience. Parametric quantification of the tissue T1 relaxation parameter offsets the propensity for these effects, but is typically time consuming. For this reason, this study examines the feasibility of rapid 2D T1 quantification using a variable flip angles (VFA) approach at magnetic field strengths of 1.5 Tesla, 3 Tesla, and 7 Tesla. These efforts include validation in phantom experiments and application for brain T1 mapping. Methods T1 quantification included simulations of the Bloch equations to correct for slice profile imperfections, and a correction for B1+. Fast gradient echo acquisitions were conducted using three adjusted flip angles for the proposed T1 quantification approach that was benchmarked against slice profile uncorrected 2D VFA and an inversion-recovery spin-echo based reference method. Brain T1 mapping was performed in six healthy subjects, one multiple sclerosis patient, and one stroke patient. Results Phantom experiments showed a mean T1 estimation error of (-63±1.5)% for slice profile uncorrected 2D VFA and (0.2±1.4)% for the proposed approach compared to the reference method. Scan time for single slice T1 mapping including B1+ mapping could be reduced to 5 seconds using an in-plane resolution of (2×2) mm2, which equals a scan time reduction of more than 99% compared to the reference method. Conclusion Our results demonstrate that rapid 2D T1 quantification using a variable flip angle approach is feasible at 1.5T/3T/7T. It represents a valuable alternative for rapid T1 mapping due to the gain in speed versus conventional approaches. This progress may serve to enhance the capabilities of parametric MR based lesion detection and brain tissue characterization. PMID:24621588

Rapid parametric mapping of the longitudinal relaxation time T1 using two-dimensional variable flip angle magnetic resonance imaging at 1.5 Tesla, 3 Tesla, and 7 Tesla.

PubMed

Dieringer, Matthias A; Deimling, Michael; Santoro, Davide; Wuerfel, Jens; Madai, Vince I; Sobesky, Jan; von Knobelsdorff-Brenkenhoff, Florian; Schulz-Menger, Jeanette; Niendorf, Thoralf

2014-01-01

Visual but subjective reading of longitudinal relaxation time (T1) weighted magnetic resonance images is commonly used for the detection of brain pathologies. For this non-quantitative measure, diagnostic quality depends on hardware configuration, imaging parameters, radio frequency transmission field (B1+) uniformity, as well as observer experience. Parametric quantification of the tissue T1 relaxation parameter offsets the propensity for these effects, but is typically time consuming. For this reason, this study examines the feasibility of rapid 2D T1 quantification using a variable flip angles (VFA) approach at magnetic field strengths of 1.5 Tesla, 3 Tesla, and 7 Tesla. These efforts include validation in phantom experiments and application for brain T1 mapping. T1 quantification included simulations of the Bloch equations to correct for slice profile imperfections, and a correction for B1+. Fast gradient echo acquisitions were conducted using three adjusted flip angles for the proposed T1 quantification approach that was benchmarked against slice profile uncorrected 2D VFA and an inversion-recovery spin-echo based reference method. Brain T1 mapping was performed in six healthy subjects, one multiple sclerosis patient, and one stroke patient. Phantom experiments showed a mean T1 estimation error of (-63±1.5)% for slice profile uncorrected 2D VFA and (0.2±1.4)% for the proposed approach compared to the reference method. Scan time for single slice T1 mapping including B1+ mapping could be reduced to 5 seconds using an in-plane resolution of (2×2) mm2, which equals a scan time reduction of more than 99% compared to the reference method. Our results demonstrate that rapid 2D T1 quantification using a variable flip angle approach is feasible at 1.5T/3T/7T. It represents a valuable alternative for rapid T1 mapping due to the gain in speed versus conventional approaches. This progress may serve to enhance the capabilities of parametric MR based lesion detection and brain tissue characterization.

Turbulent eddy diffusion models in exposure assessment - Determination of the eddy diffusion coefficient.

PubMed

Shao, Yuan; Ramachandran, Sandhya; Arnold, Susan; Ramachandran, Gurumurthy

2017-03-01

The use of the turbulent eddy diffusion model and its variants in exposure assessment is limited due to the lack of knowledge regarding the isotropic eddy diffusion coefficient, D T . But some studies have suggested a possible relationship between D T and the air changes per hour (ACH) through a room. The main goal of this study was to accurately estimate D T for a range of ACH values by minimizing the difference between the concentrations measured and predicted by eddy diffusion model. We constructed an experimental chamber with a spatial concentration gradient away from the contaminant source, and conducted 27 3-hr long experiments using toluene and acetone under different air flow conditions (0.43-2.89 ACHs). An eddy diffusion model accounting for chamber boundary, general ventilation, and advection was developed. A mathematical expression for the slope based on the geometrical parameters of the ventilation system was also derived. There is a strong linear relationship between D T and ACH, providing a surrogate parameter for estimating D T in real-life settings. For the first time, a mathematical expression for the relationship between D T and ACH has been derived that also corrects for non-ideal conditions, and the calculated value of the slope between these two parameters is very close to the experimentally determined value. The values of D T obtained from the experiments are generally consistent with values reported in the literature. They are also independent of averaging time of measurements, allowing for comparison of values obtained from different measurement settings. These findings make the use of turbulent eddy diffusion models for exposure assessment in workplace/indoor environments more practical.

A Rough Energy Landscape to Describe Surface-Linked Antibody and Antigen Bond Formation.

PubMed

Limozin, Laurent; Bongrand, Pierre; Robert, Philippe

2016-10-12

Antibodies and B cell receptors often bind their antigen at cell-cell interface while both molecular species are surface-bound, which impacts bond kinetics and function. Despite the description of complex energy landscapes for dissociation kinetics which may also result in significantly different association kinetics, surface-bound molecule (2D) association kinetics usually remain described by an on-rate due to crossing of a single free energy barrier, and few experimental works have measured association kinetics under conditions implying force and two-dimensional relative ligand-receptor motion. We use a new laminar flow chamber to measure 2D bond formation with systematic variation of the distribution of encounter durations between antigen and antibody, in a range from 0.1 to 10 ms. Under physiologically relevant forces, 2D association is 100-fold slower than 3D association as studied by surface plasmon resonance assays. Supported by brownian dynamics simulations, our results show that a minimal encounter duration is required for 2D association; an energy landscape featuring a rough initial part might be a reasonable way of accounting for this. By systematically varying the temperature of our experiments, we evaluate roughness at 2k B T, in the range of previously proposed rough parts of landscapes models during dissociation.

Motor cortex guides selection of predictable movement targets

PubMed Central

Woodgate, Philip J.W.; Strauss, Soeren; Sami, Saber A.; Heinke, Dietmar

2016-01-01

The present paper asks whether the motor cortex contributes to prediction-based guidance of target selection. This question was inspired by recent evidence that suggests (i) recurrent connections from the motor system into the attentional system may extract movement-relevant perceptual information and (ii) that the motor cortex cannot only generate predictions of the sensory consequences of movements but may also operate as predictor of perceptual events in general. To test this idea we employed a choice reaching task requiring participants to rapidly reach and touch a predictable or unpredictable colour target. Motor cortex activity was modulated via transcranial direct current stimulation (tDCS). In Experiment 1 target colour repetitions were predictable. Under such conditions anodal tDCS facilitated selection versus sham and cathodal tDCS. This improvement was apparent for trajectory curvature but not movement initiation. Conversely, where no predictability of colour was embedded reach performance was unaffected by tDCS. Finally, the results of a key-press experiment suggested that motor cortex involvement is restricted to tasks where the predictable target colour is movement-relevant. The outcomes are interpreted as evidence that the motor system contributes to the top-down guidance of selective attention to movement targets. PMID:25835319

Dose-Response Relationship between Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Regression Analysis of Prospective Cohort Studies

PubMed Central

Fang, Xin; Han, Hedong; Li, Mei; Liang, Chun; Fan, Zhongjie; Aaseth, Jan; He, Jia; Montgomery, Scott; Cao, Yang

2016-01-01

The epidemiological evidence for a dose-response relationship between magnesium intake and risk of type 2 diabetes mellitus (T2D) is sparse. The aim of the study was to summarize the evidence for the association of dietary magnesium intake with risk of T2D and evaluate the dose-response relationship. We conducted a systematic review and meta-analysis of prospective cohort studies that reported dietary magnesium intake and risk of incident T2D. We identified relevant studies by searching major scientific literature databases and grey literature resources from their inception to February 2016. We included cohort studies that provided risk ratios, i.e., relative risks (RRs), odds ratios (ORs) or hazard ratios (HRs), for T2D. Linear dose-response relationships were assessed using random-effects meta-regression. Potential nonlinear associations were evaluated using restricted cubic splines. A total of 25 studies met the eligibility criteria. These studies comprised 637,922 individuals including 26,828 with a T2D diagnosis. Compared with the lowest magnesium consumption group in the population, the risk of T2D was reduced by 17% across all the studies; 19% in women and 16% in men. A statistically significant linear dose-response relationship was found between incremental magnesium intake and T2D risk. After adjusting for age and body mass index, the risk of T2D incidence was reduced by 8%–13% for per 100 mg/day increment in dietary magnesium intake. There was no evidence to support a nonlinear dose-response relationship between dietary magnesium intake and T2D risk. The combined data supports a role for magnesium in reducing risk of T2D, with a statistically significant linear dose-response pattern within the reference dose range of dietary intake among Asian and US populations. The evidence from Europe and black people is limited and more prospective studies are needed for the two subgroups. PMID:27869762

Multispectroscopic methods reveal different modes of interaction of anti cancer drug mitoxantrone with Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT).

PubMed

Awasthi, Pamita; Dogra, Shilpa; Barthwal, Ritu

2013-10-05

The interaction of mitoxantrone with alternating Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT) duplex has been studied by absorption, fluorescence and Circular Dichroism (CD) spectroscopy at Drug to Phosphate base pair ratios D/P=20.0-0.04. Binding to GC polymer occurs in two distinct modes: partial stacking characterized by red shifts of 18-23nm at D/P=0.2-0.8 and external binding at D/P=1.0-20.0 whereas that to AT polymer occurs externally in the entire range of D/P. The binding constant and number of binding sites is 3.7×10(5)M(-1), 0.3 and 1.3× 10(4)M(-1), 1.5 in GC and AT polymers, respectively at low D/P ratios. CD binding isotherms show breakpoints at D/P=0.1, 0.5 and 0.25, 0.5 in GC and AT polymers, respectively. The intrinsic CD bands indicate that the distortions in GC polymer are significantly higher than that in AT polymer. Docking studies show partial insertion of mitoxantrone rings between to GC base pairs in alternating GC polymer. Side chains of mitoxantrone interact specifically with base pairs and DNA backbone. The studies are relevant to the understanding of suppression or inhibition of DNA cleavage on formation of ternary complex with topoisomerase-II enzyme and hence the anti cancer action. Copyright © 2013 Elsevier B.V. All rights reserved.

Surface-to-volume ratio mapping of tumor microstructure using oscillating gradient diffusion weighted imaging

PubMed Central

Reynaud, Olivier; Winters, Kerryanne Veronica; Hoang, Dung Minh; Wadghiri, Youssef Zaim; Novikov, Dmitry S; Kim, Sungheon Gene

2015-01-01

Purpose To disentangle the free diffusivity (D0) and cellular membrane restrictions, via their surface-to-volume ratio (S/V), using the frequency-dependence of the diffusion coefficient D(ω), measured in brain tumors in the short diffusion-time regime using oscillating gradients (OGSE). Methods In vivo and ex vivo OGSE experiments were performed on mice bearing the GL261 murine glioma model (n=10) to identify the relevant time/frequency (t/ω) domain where D(ω) linearly decreases with ω−1/2. Parametric maps (S/V, D0) are compared to conventional DWI metrics. The impact of frequency range and temperature (20°C vs. 37°C) on S/V and D0 is investigated ex vivo. Results The validity of the short diffusion-time regime is demonstrated in vivo and ex vivo. Ex vivo measurements confirm that the purely geometric restrictions embodied in S/V are independent from temperature and frequency range, while the temperature dependence of the free diffusivity D0 is similar to that of pure water. Conclusion Our results suggest that D(ω) in the short diffusion-time regime can be used to uncouple the purely geometric restriction effect, such as S/V, from the intrinsic medium diffusivity properties, and provides a non-empirical and objective way to interpret frequency/time-dependent diffusion changes in tumors in terms of objective biophysical tissue parameters. PMID:26207354

Improving phenolic bioactive-linked anti-hyperglycemic functions of dark germinated barley sprouts (Hordeum vulgare L.) using seed elicitation strategy.

PubMed

Ramakrishna, Ramnarain; Sarkar, Dipayan; Manduri, Avani; Iyer, Shreyas Ganesan; Shetty, Kalidas

2017-10-01

Sprouts of cereal grains, such as barley ( Hordeum vulgare L.), are a good source of beneficial phenolic bioactives. Such health relevant phenolic bioactives of cereal sprouts can be targeted to manage chronic hyperglycemia and oxidative stress commonly associated with type 2 diabetes (T2D). Therefore improving phenolic bioactives by stimulating plant endogenous defense responses such as protective pentose phosphate pathway (PPP) during sprouting has significant merit. Based on this metabolic rationale, this study aimed to enhance phenolic bioactives and associated antioxidant and anti-hyperglycemic functions in dark germinated barley sprouts using exogenous elicitor treatments. Dark-germinated sprouts of two malting barley cultivars (Pinnacle and Celebration), treated with chitosan oligosaccharide (COS) and marine protein hydrolysate (GP), were evaluated. Total soluble phenolic content (TSP), phenolic acid profiles, total antioxidant activity (TA) and in vitro inhibitory activities of hyperglycemia relevant α-amylase and α-glucosidase enzymes of the dark germinated barley sprouts were evaluated at day 2, 4, and 6 post elicitor treatments. Overall, TSP content, TA, and α-amylase inhibitory activity of dark germinated barley sprouts decreased, while α-glucosidase inhibitory activity and gallic acid content increased from day 2 to day 6. Among barley cultivars, high phenolic antioxidant-linked anti-hyperglycemic bioactives were observed in Celebration. Furthermore, GP and COS seed elicitor treatments in selective doses improved T2D relevant phenolic-linked anti-hyperglycemic bioactives of barley spouts at day 6. Therefore, such seed elicitation approach can be strategically used to develop bioactive enriched functional food ingredients from cereal sprouts targeting chronic hyperglycemia and oxidative stress linked to T2D.

In vivo 1D and 2D correlation MR spectroscopy of the soleus muscle at 7T

PubMed Central

Ramadan, Saadallah; Ratai, Eva-Maria; Wald, Lawrence L.; Mountford, Carolyn E.

2013-01-01

Aim This study aims to (1) undertake and analyse 1D and 2D MR correlation spectroscopy from human soleus muscle in vivo at 7T, and (2) determine T1 and T2 relaxation time constants at 7T field strength due to their importance in sequence design and spectral quantitation. Method Six healthy, male volunteers were consented and scanned on a 7T whole-body scanner (Siemens AG, Erlangen, Germany). Experiments were undertaken using a 28 cm diameter detunable birdcage coil for signal excitation and an 8.5 cm diameter surface coil for signal reception. The relaxation time constants, T1 and T2 were recorded using a STEAM sequence, using the ‘progressive saturation’ method for the T1 and multiple echo times for T2. The 2D L-Correlated SpectroscopY (L-COSY) method was employed with 64 increments (0.4 ms increment size) and eight averages per scan, with a total time of 17 min. Results T1 and T2 values for the metabolites of interest were determined. The L-COSY spectra obtained from the soleus muscle provided information on lipid content and chemical structure not available, in vivo, at lower field strengths. All molecular fragments within multiple lipid compartments were chemically shifted by 0.20–0.26 ppm at this field strength. 1D and 2D L-COSY spectra were assigned and proton connectivities were confirmed with the 2D method. Conclusion In vivo 1D and 2D spectroscopic examination of muscle can be successfully recorded at 7T and is now available to assess lipid alterations as well as other metabolites present with disease. T1 and T2 values were also determined in soleus muscle of male healthy volunteers. PMID:20206561

Actual Operation Simulation of RESSOX Ground Experiments

DTIC Science & Technology

2010-11-01

Note 1289,” (Hewlett-Packard), 60 pp. [5] F. Tappero, A. Dempster, T . Iwata, M. Imae, T . Ikegami , Y. Fukuyama, K. Hagimoto, and A. Iwasaki, 2006...Delay Ionospheric Delay Ku-band Delay Estimation Frequency- Independent part Frequency- Dependent part Elapsed Time with Current Time Set as 0 (s) T ...im e t o b e A d ju s te d 0-6-105 Extrapolated with First- Order Least-Squares Filter Time Adjustment Command 42 nd Annual Precise Time and Time

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

PubMed Central

Zhang, Guanglin; Codoni, Veronica; Yang, Jun; Wilson, James G.; Levy, Daniel; Lusis, Aldons J.; Liu, Simin; Yang, Xia

2017-01-01

Cardiovascular diseases (CVD) and type 2 diabetes (T2D) are closely interrelated complex diseases likely sharing overlapping pathogenesis driven by aberrant activities in gene networks. However, the molecular circuitries underlying the pathogenic commonalities remain poorly understood. We sought to identify the shared gene networks and their key intervening drivers for both CVD and T2D by conducting a comprehensive integrative analysis driven by five multi-ethnic genome-wide association studies (GWAS) for CVD and T2D, expression quantitative trait loci (eQTLs), ENCODE, and tissue-specific gene network models (both co-expression and graphical models) from CVD and T2D relevant tissues. We identified pathways regulating the metabolism of lipids, glucose, and branched-chain amino acids, along with those governing oxidation, extracellular matrix, immune response, and neuronal system as shared pathogenic processes for both diseases. Further, we uncovered 15 key drivers including HMGCR, CAV1, IGF1 and PCOLCE, whose network neighbors collectively account for approximately 35% of known GWAS hits for CVD and 22% for T2D. Finally, we cross-validated the regulatory role of the top key drivers using in vitro siRNA knockdown, in vivo gene knockout, and two Hybrid Mouse Diversity Panels each comprised of >100 strains. Findings from this in-depth assessment of genetic and functional data from multiple human cohorts provide strong support that common sets of tissue-specific molecular networks drive the pathogenesis of both CVD and T2D across ethnicities and help prioritize new therapeutic avenues for both CVD and T2D. PMID:28957322

Characterizing diabetes burnout in parents of youth with type 1 diabetes (T1D)[abstract

USDA-ARS?s Scientific Manuscript database

Managing T1D is complex and requires round-the-clock attention, much of which falls to parents. Parental stress and family conflict about diabetes are associated with suboptimal youth self management and glycemic outcomes, yet little research has described parents' experiences with burnout or tested...

Characterizing diabetes burnout in parents of youth with type 1 diabetes (T1D)

USDA-ARS?s Scientific Manuscript database

Managing type 1 diabetes (T1D) is complex and requires round-the-clock attention, much of which falls to parents. Parental stress and family conflict about diabetes are associated with suboptimal youth self-management and glycemic outcomes, yet little research has described parents' experiences with...

Productivity Measurement in R&D: Productivity Measurement Experiment (PROMEX) in Selected Research and Development Programs at the National Bureau of Standards

DTIC Science & Technology

1975-12-01

Frequency Standards R. A. Kamper, Cryoelectronics D. B. Mann, Cryogenic Metrology Other Contributors: T. Dillon S. Dunaway J. Ellermeier K. T. Higgins R...research projects could be continuously assessed. Lipetz,, Ben-Ami. The Measueement of Efficiency of Scientific Research. Intermedia , Inc., Carlisle

In vivo Discovery of Immunotherapy Targets in the Tumor Microenvironment

PubMed Central

Zhou, Penghui; Shaffer, Donald R.; Arias, Diana A. Alvarez; Nakazaki, Yukoh; Pos, Wouter; Torres, Alexis J.; Cremasco, Viviana; Dougan, Stephanie K.; Cowley, Glenn S.; Elpek, Kutlu; Brogdon, Jennifer; Lamb, John; Turley, Shannon; Ploegh, Hidde L.; Root, David E.; Love, J. Christopher; Dranoff, Glenn; Hacohen, Nir; Cantor, Harvey; Wucherpfennig, Kai W.

2014-01-01

Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced disease. However, the regulatory switches controlling T cell function in immunosuppressive tumors are not well understood. Here we show that such inhibitory mechanisms can be systematically discovered in the tumor microenvironment. We devised an in vivo pooled shRNA screen in which shRNAs targeting negative regulators became highly enriched in tumors by releasing a block on T cell proliferation upon tumor antigen recognition. Such shRNAs were identified by deep sequencing of the shRNA cassette from T cells infiltrating tumor or control tissues. One of the target genes was Ppp2r2d, a regulatory subunit of the PP2A phosphatase family: In tumors, Ppp2r2d knockdown inhibited T cell apoptosis and enhanced T cell proliferation as well as cytokine production. Key regulators of immune function can thus be discovered in relevant tissue microenvironments. PMID:24476824

Evolution of the single-mode Rayleigh-Taylor instability under the influence of time-dependent accelerations

NASA Astrophysics Data System (ADS)

Ramaprabhu, P.; Karkhanis, V.; Banerjee, R.; Varshochi, H.; Khan, M.; Lawrie, A. G. W.

2016-01-01

From nonlinear models and direct numerical simulations we report on several findings of relevance to the single-mode Rayleigh-Taylor (RT) instability driven by time-varying acceleration histories. The incompressible, direct numerical simulations (DNSs) were performed in two (2D) and three dimensions (3D), and at a range of density ratios of the fluid combinations (characterized by the Atwood number). We investigated several acceleration histories, including acceleration profiles of the general form g (t ) ˜tn , with n ≥0 and acceleration histories reminiscent of the linear electric motor experiments. For the 2D flow, results from numerical simulations compare well with a 2D potential flow model and solutions to a drag-buoyancy model reported as part of this work. When the simulations are extended to three dimensions, bubble and spike growth rates are in agreement with the so-called level 2 and level 3 models of Mikaelian [K. O. Mikaelian, Phys. Rev. E 79, 065303(R) (2009), 10.1103/PhysRevE.79.065303], and with corresponding 3D drag-buoyancy model solutions derived in this article. Our generalization of the RT problem to study variable g (t ) affords us the opportunity to investigate the appropriate scaling for bubble and spike amplitudes under these conditions. We consider two candidates, the displacement Z and width s2, but find the appropriate scaling is dependent on the density ratios between the fluids—at low density ratios, bubble and spike amplitudes are explained by both s2 and Z , while at large density differences the displacement collapses the spike data. Finally, for all the acceleration profiles studied here, spikes enter a free-fall regime at lower Atwood numbers than predicted by all the models.

Envenimation scorpionique compliqué d'un accident vasculaire cérébral ischemique

PubMed Central

Bibiche, Youssef; Berdai, Adnan; Labib, Smael; Harandou, Mustapha

2015-01-01

Les piqûres de scorpion sont dans un certain nombre de pays, un accident fréquemment rencontré, et un risque grave. Au Maroc, les données épidémiologiques établies par le centre anti-poison (CAPM) montrent que les piqûres scorpioniques se placent en tête de toutes les intoxications relevées par le centre (60%). Les envenimations scorpioniques posent un grand problème de santé publique. L'apparition de signes neurologiques lors d'une envenimation scorpionique témoigne d'une envenimation grave et correspond au stade III de l’échelle de sévérité. Nous rapportons le cas d'une envenimation scorpionique compliqué d'un Accident vasculaire cérébral ischémique (AVCI) chez un enfant. PMID:26175806

Multidimensional Space-Time Methodology for Development of Planetary and Space Sciences, S-T Data Management and S-T Computational Tomography

NASA Astrophysics Data System (ADS)

Andonov, Zdravko

This R&D represent innovative multidimensional 6D-N(6n)D Space-Time (S-T) Methodology, 6D-6nD Coordinate Systems, 6D Equations, new 6D strategy and technology for development of Planetary Space Sciences, S-T Data Management and S-T Computational To-mography. . . The Methodology is actual for brain new RS Microwaves' Satellites and Compu-tational Tomography Systems development, aimed to defense sustainable Earth, Moon, & Sun System evolution. Especially, extremely important are innovations for monitoring and protec-tion of strategic threelateral system H-OH-H2O Hydrogen, Hydroxyl and Water), correspond-ing to RS VHRS (Very High Resolution Systems) of 1.420-1.657-22.089GHz microwaves. . . One of the Greatest Paradox and Challenge of World Science is the "transformation" of J. L. Lagrange 4D Space-Time (S-T) System to H. Minkovski 4D S-T System (O-X,Y,Z,icT) for Einstein's "Theory of Relativity". As a global result: -In contemporary Advanced Space Sciences there is not real adequate 4D-6D Space-Time Coordinate System and 6D Advanced Cosmos Strategy & Methodology for Multidimensional and Multitemporal Space-Time Data Management and Tomography. . . That's one of the top actual S-T Problems. Simple and optimal nD S-T Methodology discovery is extremely important for all Universities' Space Sci-ences' Education Programs, for advances in space research and especially -for all young Space Scientists R&D!... The top ten 21-Century Challenges ahead of Planetary and Space Sciences, Space Data Management and Computational Space Tomography, important for successfully de-velopment of Young Scientist Generations, are following: 1. R&D of W. R. Hamilton General Idea for transformation all Space Sciences to Time Sciences, beginning with 6D Eukonal for 6D anisotropic mediums & velocities. Development of IERS Earth & Space Systems (VLBI; LLR; GPS; SLR; DORIS Etc.) for Planetary-Space Data Management & Computational Planetary & Space Tomography. 2. R&D of S. W. Hawking Paradigm for 2D Complex Time and Quan-tum Wave Cosmology Paradigm for Decision of the Main Problem of Contemporary Physics. 3. R&D of Einstein-Minkowski Geodesies' Paradigm in the 4D-Space-Time Continuum to 6D-6nD Space-Time Continuum Paradigms and 6D S-T Equations. . . 4. R&D of Erwin Schrüdinger 4D S-T Universe' Evolutional Equation; It's David Bohm 4D generalization for anisotropic mediums and innovative 6D -for instantaneously quantum measurement -Bohm-Schrüdinger 6D S-T Universe' Evolutional Equation. 5. R&D of brain new 6D Planning of S-T Experi-ments, brain new 6D Space Technicks and Space Technology Generalizations, especially for 6D RS VHRS Research, Monitoring and 6D Computational Tomography. 6. R&D of "6D Euler-Poisson Equations" and "6D Kolmogorov Turbulence Theory" for GeoDynamics and for Space Dynamics as evolution of Gauss-Riemann Paradigms. 7. R&D of N. Boneff NASA RD for Asteroid "Eros" & Space Science' Laws Evolution. 8. R&D of H. Poincare Paradigm for Nature and Cosmos as 6D Group of Transferences. 9. R&D of K. Popoff N-Body General Problem & General Thermodynamic S-T Theory as Einstein-Prigogine-Landau' Paradigms Development. ü 10. R&D of 1st GUT since 1958 by N. S. Kalitzin (Kalitzin N. S., 1958: Uber eine einheitliche Feldtheorie. ZAHeidelberg-ARI, WZHUmnR-B., 7 (2), 207-215) and "Multitemporal Theory of Relativity" -With special applications to Photon Rockets and all Space-Time R&D. GENERAL CONCLUSION: Multidimensional Space-Time Methodology is advance in space research, corresponding to the IAF-IAA-COSPAR Innovative Strategy and R&D Programs -UNEP, UNDP, GEOSS, GMES, Etc.

Non-Markovian effects in the first-passage dynamics of obstructed tracer particle diffusion in one-dimensional systems

NASA Astrophysics Data System (ADS)

Forsling, Robin; Sanders, Lloyd P.; Ambjörnsson, Tobias; Lizana, Ludvig

2014-09-01

The standard setup for single-file diffusion is diffusing particles in one dimension which cannot overtake each other, where the dynamics of a tracer (tagged) particle is of main interest. In this article, we generalize this system and investigate first-passage properties of a tracer particle when flanked by identical crowder particles which may, besides diffuse, unbind (rebind) from (to) the one-dimensional lattice with rates koff (kon). The tracer particle is restricted to diffuse with rate kD on the lattice and the density of crowders is constant (on average). The unbinding rate koff is our key parameter and it allows us to systematically study the non-trivial transition between the completely Markovian case (koff ≫ kD) to the non-Markovian case (koff ≪ kD) governed by strong memory effects. This has relevance for several quasi one-dimensional systems. One example is gene regulation where regulatory proteins are searching for specific binding sites on a crowded DNA. We quantify the first-passage time distribution, f (t) (t is time), numerically using the Gillespie algorithm, and estimate f (t) analytically. In terms of koff (keeping kD fixed), we study the transition between the two known regimes: (i) when koff ≫ kD the particles may effectively pass each other and we recover the single particle result f (t) ˜ t-3/2, with a reduced diffusion constant; (ii) when koff ≪ kD unbinding is rare and we obtain the single-file result f (t) ˜ t-7/4. The intermediate region displays rich dynamics where both the characteristic f (t) - peak and the long-time power-law slope are sensitive to koff.

Detecting diffusion-diffraction patterns in size distribution phantoms using double-pulsed field gradient NMR: Theory and experiments.

PubMed

Shemesh, Noam; Ozarslan, Evren; Basser, Peter J; Cohen, Yoram

2010-01-21

NMR observable nuclei undergoing restricted diffusion within confining pores are important reporters for microstructural features of porous media including, inter-alia, biological tissues, emulsions and rocks. Diffusion NMR, and especially the single-pulsed field gradient (s-PFG) methodology, is one of the most important noninvasive tools for studying such opaque samples, enabling extraction of important microstructural information from diffusion-diffraction phenomena. However, when the pores are not monodisperse and are characterized by a size distribution, the diffusion-diffraction patterns disappear from the signal decay, and the relevant microstructural information is mostly lost. A recent theoretical study predicted that the diffusion-diffraction patterns in double-PFG (d-PFG) experiments have unique characteristics, such as zero-crossings, that make them more robust with respect to size distributions. In this study, we theoretically compared the signal decay arising from diffusion in isolated cylindrical pores characterized by lognormal size distributions in both s-PFG and d-PFG methodologies using a recently presented general framework for treating diffusion in NMR experiments. We showed the gradual loss of diffusion-diffraction patterns in broadening size distributions in s-PFG and the robustness of the zero-crossings in d-PFG even for very large standard deviations of the size distribution. We then performed s-PFG and d-PFG experiments on well-controlled size distribution phantoms in which the ground-truth is well-known a priori. We showed that the microstructural information, as manifested in the diffusion-diffraction patterns, is lost in the s-PFG experiments, whereas in d-PFG experiments the zero-crossings of the signal persist from which relevant microstructural information can be extracted. This study provides a proof of concept that d-PFG may be useful in obtaining important microstructural features in samples characterized by size distributions.

What Does (and Doesn't) Make Analogical Problem Solving Easy? A Complexity-Theoretic Perspective

ERIC Educational Resources Information Center

Wareham, Todd; Evans, Patricia; van Rooij, Iris

2011-01-01

Solving new problems can be made easier if one can build on experiences with other problems one has already successfully solved. The ability to exploit earlier problem-solving experiences in solving new problems seems to require several cognitive sub-abilities. Minimally, one needs to be able to retrieve relevant knowledge of earlier solved…

Analysis Strategy and Selection Procedure for νμ Charged Current Inclusive Interactions using the ^0 Detector (P0D) and the Time Projection Chambers of the T2K Experiment

NASA Astrophysics Data System (ADS)

Reinherz-Aronis, Erez; Clifton, Alex; Das, Raj; Toki, Walter; Johnson, Robert; Marino, Alysia; Yuan, Tianlu

2013-04-01

νμ Charge-Current events are produced and collected by the Near Detectors (ND280) in the Tokai to Kamioka (T2K) experiment. This talk focuses on those interactions that are created in the Pi-Zero detector (PøD) and whose momentum is measured by the Time Projection Chambers (TPC). The description of the analysis event selection is presented which includes Data-Quality cuts, Beam Quality parameters, and Fiducial Volume boundaries which are applied on the beginning of the PøD track. In addition the matching procedure of a TPC track to a PøD track and the optimization of this procedure in presented.

[Effects of micro-sprinkling hose length and width on wheat field water condition and flag leaf chlorophyll fluorescence characteristics in different sampling districts].

PubMed

Xu, Ji Kun; Yu, Zhen Wen; Shi, Yu; Zhao, Jun Ye; Wang, Xi Zhi; Wang, Yu Qiu

2017-11-01

A two-year field experiment was conducted in 2014-2015 and 2015-2016 wheat growing seasons to study the effects of micro-sprinkling hose length and width on field water condition, and flag leaf chlorophyll fluorescence characteristics in different sampling districts (D 1 to D 6 along with the hose laying direction). Six micro-sprinkling hose treatments were set: 60 m (T 1 ), 80 m (T 2 ) and 100 m (T 3 ) lengths under 65 mm width; 60 m (T 4 ), 80 m (T 5 ) and 100 m (T 6 ) lengths under 80 mm width. The results showed that after irrigation at jointing, the Christiansen uniformity coefficient (C u ) of T 1 was significantly higher than T 2 and T 3 under 65 mm hose width. Under 80 mm hose width, T 4 and T 5 had the highest C u compared to T 6 . After irrigation at anthesis, the C u showed T 1 >T 2 >T 3 under 65 mm hose width, and T 4 >T 5 >T 6 under 80 mm hose width. Under 65 mm hose width, the average relative soil water content of 0-40 cm soil layers after irrigation at anthesis, flag leaf Φ PSII , NPQ and ETR at 20 and 30 d after anthesis and the grain yield of different sampling district did not differ in T 1 ; T 2 showed the order of D 1 , D 2 >D 3 >D 4 >D 5 ; T 3 showed D 1 , D 2 >D 3 >D 4 >D 5 , D 6 . The average Φ PSII , NPQ and ETR at 20 and 30 d after anthesis, and the average dry matter at maturity of different sampling districts were presented as T 1 >T 2 , T 3 . Under 85 mm hose width, no significant differences were observed in the average relative soil water content of 0-40 cm soil layers after irrigation at ahthesis, flag leaf Φ PSII , NPQ and ETR at 20 and 30 d after anthesis and the grain yield of different sampling districts in T 4 ; in T 5 , the indexes mentioned above in D 1 , D 2 and D 3 sampling districts were significantly higher than those in D 4 and D 5 ; in T 6 , the decreasing order was D 1 , D 2 , D 3 >D 4 >D 5 >T 6 . The average Φ PSII , NPQ and ETR at 20 and 30 d after anthesis, and the average dry matter at maturity of different districts showed the order of T 4 , T 5 >T 6 . The ave-rage grain yield and water use efficiency of T 1 , T 4 and T 5 were significantly higher than those in T 2 , T 3 and T 6 , T 1 and T 4 had a better irrigation benefit than T 5 . Under this experimental condition, T 1 treatment under 65 mm hose width, T 4 treatment under 80 mm hose width were the most recommendable treatments considering high yield and water saving, and T 5 treatment was also recommendable under 80 mm hose width.

Willingness to pay for flexible working conditions of people with type 2 diabetes: discrete choice experiments.

PubMed

Nexo, M A; Cleal, B; Hagelund, Lise; Willaing, I; Olesen, K

2017-12-15

The increasing number of people with chronic diseases challenges workforce capacity. Type 2 diabetes (T2D) can have work-related consequences, such as early retirement. Laws of most high-income countries require workplaces to provide accommodations to enable people with chronic disabilities to manage their condition at work. A barrier to successful implementation of such accommodations can be lack of co-workers' willingness to support people with T2D. This study aimed to examine the willingness to pay (WTP) of people with and without T2D for five workplace initiatives that help individuals with type 2 diabetes manage their diabetes at work. Three samples with employed Danish participants were drawn from existing online panels: a general population sample (n = 600), a T2D sample (n = 693), and a matched sample of people without diabetes (n = 539). Participants completed discrete choice experiments eliciting their WTP (reduction in monthly salary, €/month) for five hypothetical workplace initiatives: part-time job, customized work, extra breaks with pay, and time off for medical consultations with and without pay. WTP was estimated by conditional logits models. Bootstrapping was used to estimate confidence intervals for WTP. There was an overall WTP for all initiatives. Average WTP for all attributes was 34 €/month (95% confidence interval [CI]: 27-43] in the general population sample, 32 €/month (95% CI: 26-38) in the T2D sample, and 55 €/month (95% CI: 43-71) in the matched sample. WTP for additional breaks with pay was considerably lower than for the other initiatives in all samples. People with T2D had significantly lower WTP than people without diabetes for part-time work, customized work, and time off without pay, but not for extra breaks or time off with pay. For people with and without T2D, WTP was present for initiatives that could improve management of diabetes at the workplace. WTP was lowest among people with T2D. Implementation of these initiatives seems feasible and may help unnecessary exclusion of people with T2D from work.

DOE Office of Scientific and Technical Information (OSTI.GOV)

T.Rex is used to explore tabular data sets containing up to ten million records to help rapidly understand a previously unknown data set. Analysis can quickly identify patterns of interest and the records and fields that capture those patterns. T.Rex contains a growing set of deep analytical tools and supports robust export capabilities that selected data can be incorporated into to other specialized tools for further analysis. T.Rex is flexible in ingesting different types and formats of data, allowing the user to interactively experiment and perform trial and error guesses on the structure of the data; and also has amore » variety of linked visual analytic tools that enable exploration of the data to find relevant content, relationships among content, trends within the content, and capture knowledge about the content. Finally, T.Rex has a rich export capability, to extract relevant subsets of a larger data source, to further analyze their data in other analytic tools.« less

Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.

PubMed

Dall'Acqua, Stefano; Peron, Gregorio; Ferrari, Sara; Gandin, Valentina; Bramucci, Massimo; Quassinti, Luana; Mártonfi, Pavol; Maggi, Filippo

2017-12-01

Thymus alternans Klokov (Lamiaceae) is a neglected species of the genus Thymus (Sect. Serpyllum) endemic to Carpathian area, where it is used as a flavouring agent and for medicinal purposes. The aim of the work was to identify antiproliferative constituents from the flowering aerial parts of this plant. Thymus alternans extracts were analyzed by HPLC-MS n and subjected to extensive chromatographic separations. The isolated compounds (phenolics and triterpenes) were structurally elucidated by MS and 1D and 2D NMR experiments. Essential oil (EO) composition was determined by GC-FID and GC-MS. Six purified triterpenes and EO were assayed for in vitro antiproliferative activity against a panel of human cancer cells, namely, breast (MDA-MB 231), colon (HCT-15 and HCT116), lung (U1810), pancreatic (BxPC3), melanoma (A375) and cervical carcinoma (A431) cells. The structures of the isolated compounds were achieved on the basis of H-NMR and MS experiments. Luteolin-4'-O-β-d-glucopyranoside (P1), chrysoeriol-7-O-β-d-glucopyranoside (P2), chrysoeriol-5-O-β-d-glucopyranoside (P3), apigenin-7-O-β-d-glucopyranoside (P4), rosmarinic acid (P5), rosmarinic acid-3'-O-β-d-glucopyranoside (P6), caffeic acid-3-O-β-d-glucopyranoside (P7), 3α-hydroxy-urs-12,15-diene (T1), α-amyrin (T2), β-amyrin (T3), isoursenol (T4), epitaraxerol (T5), and oleanolic acid (T6). GC-MS analysis revealed that the EO of T. alternans was devoid of phenols and belonged to the nerolidol-chemotype, that is typical of the Sect. Serpyllum. The six purified triterpenes (T1-T6) were active with IC 50 ranging from 0.5 to 5 μM being comparable or better than those of reference compounds betulinic acid and cisplatin. The EO exhibited significant effects on A375, MDA-MB 231 and HCT116 cell lines with IC 50 in the range of 5-8 μg/mL. The reported results suggest that T. alternans can be considered as a good source of phytoconstituents with possible importance in the pharmaceutical field.

Tridimensional Thermonuclear Instability in Subignited Plasmas and on the Surface of the Pulsars

NASA Astrophysics Data System (ADS)

Cardinali, A.; Coppi, B.

2016-10-01

Tridimensional modes involving an increase of the electron temperature can be excited as a result of α-particle heating in subignited D-T fusion burning plasmas when a nearly time- independent external source of heating is applied. The analyzed modes are shown to emerge from an axisymmetric toroidal configurations and are radially localized around rational magnetic surfaces corresponding to q(r =r0) =m0 /n0 where m0 and n0 are the relevant poloidal and toroidal mode numbers. The radial width of the mode is of the order of the thermal scale distances δT =D⊥e th /D∥e th 1/4 (R0 /n0) 1/2(dlnq/dr)0-1/2. The mode has a rather severe damping rate, that has to be overcome by the relevant heating rate. Thus the temperature range to be considered is that where the D-T plasma reactivity undergoes a relatively large increase as a function of temperature. This kind of theory has been applied to the plasmas that are envisioned to be associated with surface of pulsar and be subjects to (spatially) inhomogenous thermonuclear burning. Sponsored in part by the US DOE.

Whole-Genome Sequence Analysis of Bombella intestini LMG 28161T, a Novel Acetic Acid Bacterium Isolated from the Crop of a Red-Tailed Bumble Bee, Bombus lapidarius.

PubMed

Li, Leilei; Illeghems, Koen; Van Kerrebroeck, Simon; Borremans, Wim; Cleenwerck, Ilse; Smagghe, Guy; De Vuyst, Luc; Vandamme, Peter

2016-01-01

The whole-genome sequence of Bombella intestini LMG 28161T, an endosymbiotic acetic acid bacterium (AAB) occurring in bumble bees, was determined to investigate the molecular mechanisms underlying its metabolic capabilities. The draft genome sequence of B. intestini LMG 28161T was 2.02 Mb. Metabolic carbohydrate pathways were in agreement with the metabolite analyses of fermentation experiments and revealed its oxidative capacity towards sucrose, D-glucose, D-fructose and D-mannitol, but not ethanol and glycerol. The results of the fermentation experiments also demonstrated that the lack of effective aeration in small-scale carbohydrate consumption experiments may be responsible for the lack of reproducibility of such results in taxonomic studies of AAB. Finally, compared to the genome sequences of its nearest phylogenetic neighbor and of three other insect associated AAB strains, the B. intestini LMG 28161T genome lost 69 orthologs and included 89 unique genes. Although many of the latter were hypothetical they also included several type IV secretion system proteins, amino acid transporter/permeases and membrane proteins which might play a role in the interaction with the bumble bee host.

2017 Topical Workshop on Electronics for Particle Physics

NASA Astrophysics Data System (ADS)

2017-09-01

The workshop will cover all aspects of electronics for particle physics experiments, and accelerator instrumentation of general interest to users. LHC experiments (and their operational experience) will remain a focus of the meeting but a strong emphasis on R&D for future experimentation will be maintained, such as SLHC, CLIC, ILC, neutrino facilities as well as other particle and astroparticle physics experiments. The purpose of the workshop is: To present results and original concepts for electronic research and development relevant to experiments as well as accelerator and beam instrumentation at future facilities; To review the status of electronics for the LHC experiments; To identify and encourage common efforts for the development of electronics; To promote information exchange and collaboration in the relevant engineering and physics communities.

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

PubMed

Simeonovic, Charmaine J; Popp, Sarah K; Starrs, Lora M; Brown, Debra J; Ziolkowski, Andrew F; Ludwig, Barbara; Bornstein, Stefan R; Wilson, J Dennis; Pugliese, Alberto; Kay, Thomas W H; Thomas, Helen E; Loudovaris, Thomas; Choong, Fui Jiun; Freeman, Craig; Parish, Christopher R

2018-01-01

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted the disease course, suggesting that other approaches are required. Our previous studies have demonstrated that heparan sulfate (HS), a glycosaminoglycan conventionally expressed in extracellular matrix, is present at high levels inside normal mouse beta cells. Intracellular HS was shown to be critical for beta cell survival and protection from oxidative damage. T1D development in Non-Obese Diabetic (NOD) mice correlated with loss of islet HS and was prevented by inhibiting HS degradation by the endoglycosidase, heparanase. In this study we investigated the distribution of HS and heparan sulfate proteoglycan (HSPG) core proteins in normal human islets, a role for HS in human beta cell viability and the clinical relevance of intra-islet HS and HSPG levels, compared to insulin, in human T1D. In normal human islets, HS (identified by 10E4 mAb) co-localized with insulin but not glucagon and correlated with the HSPG core proteins for collagen type XVIII (Col18) and syndecan-1 (Sdc1). Insulin-positive islets of T1D pancreases showed significant loss of HS, Col18 and Sdc1 and heparanase was strongly expressed by islet-infiltrating leukocytes. Human beta cells cultured with HS mimetics showed significantly improved survival and protection against hydrogen peroxide-induced death, suggesting that loss of HS could contribute to beta cell death in T1D. We conclude that HS depletion in beta cells, possibly due to heparanase produced by insulitis leukocytes, may function as an important mechanism in the pathogenesis of human T1D. Our findings raise the possibility that intervention therapy with dual activity HS replacers/heparanase inhibitors could help to protect the residual beta cell mass in patients recently diagnosed with T1D.

Probing the antagonistic effect of toluene as a component in surrogate fuel models at low temperatures and high pressures. A case study of toluene/dimethyl ether mixtures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yingjia; Somers, Kieran P.; Mehl, Marco

There is a dearth of experimental data which examine the fundamental low-temperature ignition (T < 900 K) behavior of toluene resulting in a lack of data for the construction, validation, and interpretation of chemical kinetic models for commercial fuels. In order to gain a better understanding of its combustion chemistry, dimethyl ether (DME) has been used as a radical initiator to induce ignition in this highly knock resistant aromatic, and its influence on the combustion of toluene ignition was studied in both shock tube and rapid compression machines as a function of temperature (624–1459 K), pressure (20–40 atm), equivalence ratiomore » (0.5–2.0), and blending ratio (100% toluene, 76% toluene (76T/24D), 58% toluene (58T/42D), 26% toluene (26T/74D) and 100% DME). We use several literature chemical kinetic models to interpret our experimental results. For mixtures containing high concentrations of toluene at low-temperatures none of these are capable of reproducing experiment. This then implies an incomplete understanding of the low-temperature oxidation pathways which control its ignition in our experimental reactors, and by extension, in spark- (SI) and compression-ignition (CI) engines, and an updated detailed chemical kinetic model is presented for engineering applications. Model analyses indicate that although the initial fate of the fuel is dominated by single-step H-atom abstraction reactions from both the benzylic and phenylic sites, the subsequent fate of the allylic and vinylic radicals formed is much more complex. Further experimental and theoretical endeavors are required to gain a holistic qualitative and quantitative chemical kinetics based understanding of the combustion of pure toluene, toluene blends, and commercial fuels containing other aromatic components, at temperatures of relevance to SI and CI engines.« less

Probing the antagonistic effect of toluene as a component in surrogate fuel models at low temperatures and high pressures. A case study of toluene/dimethyl ether mixtures

DOE PAGES

Zhang, Yingjia; Somers, Kieran P.; Mehl, Marco; ...

2016-07-12

There is a dearth of experimental data which examine the fundamental low-temperature ignition (T < 900 K) behavior of toluene resulting in a lack of data for the construction, validation, and interpretation of chemical kinetic models for commercial fuels. In order to gain a better understanding of its combustion chemistry, dimethyl ether (DME) has been used as a radical initiator to induce ignition in this highly knock resistant aromatic, and its influence on the combustion of toluene ignition was studied in both shock tube and rapid compression machines as a function of temperature (624–1459 K), pressure (20–40 atm), equivalence ratiomore » (0.5–2.0), and blending ratio (100% toluene, 76% toluene (76T/24D), 58% toluene (58T/42D), 26% toluene (26T/74D) and 100% DME). We use several literature chemical kinetic models to interpret our experimental results. For mixtures containing high concentrations of toluene at low-temperatures none of these are capable of reproducing experiment. This then implies an incomplete understanding of the low-temperature oxidation pathways which control its ignition in our experimental reactors, and by extension, in spark- (SI) and compression-ignition (CI) engines, and an updated detailed chemical kinetic model is presented for engineering applications. Model analyses indicate that although the initial fate of the fuel is dominated by single-step H-atom abstraction reactions from both the benzylic and phenylic sites, the subsequent fate of the allylic and vinylic radicals formed is much more complex. Further experimental and theoretical endeavors are required to gain a holistic qualitative and quantitative chemical kinetics based understanding of the combustion of pure toluene, toluene blends, and commercial fuels containing other aromatic components, at temperatures of relevance to SI and CI engines.« less

Within-Subject Reversibility of Discriminative Function in the Composite-Stimulus Control of Behavior

ERIC Educational Resources Information Center

Weiss, Stanley J.; Kearns, David N.; Antoshina, Maria

2009-01-01

According to the composite-stimulus control model (Weiss, 1969, 1972b), an individual discriminative stimulus (S[superscript D]) is composed of that S[superscript D]'s on-state plus the off-states of all other relevant S[superscript D]s. The present experiment investigated the reversibility of composite-stimulus control. Separate groups of rats…

Phase competition and anomalous thermal evolution in high-temperature superconductors

DOE PAGES

Yu, Zuo-Dong; Zhou, Yuan; Yin, Wei-Guo; ...

2017-07-12

The interplay of competing orders is relevant to high-temperature superconductivity known to emerge upon suppression of a parent antiferromagnetic order typically via charge doping. How such interplay evolves at low temperature—in particular at what doping level the zero-temperature quantum critical point (QCP) is located—is still elusive because it is masked by the superconducting state. The QCP had long been believed to follow a smooth extrapolation of the characteristic temperature T * for the strange normal state well above the superconducting transition temperature. However, recently the T * within the superconducting dome was reported to unexpectedly exhibit back-bending likely in themore » cuprate Bi 2 Sr 2 CaCu 2 O 8 + δ . We show that the original and revised phase diagrams can be understood in terms of weak and moderate competitions, respectively, between superconductivity and a pseudogap state such as d -density or spin-density wave, based on both Ginzburg-Landau theory and the realistic t - t ' - t ' ' - J - V model for the cuprates. We further found that the calculated temperature and doping-level dependence of the quasiparticle spectral gap and Raman response qualitatively agrees with the experiments. Particularly, the T * back-bending can provide a simple explanation of the observed anomalous two-step thermal evolution dominated by the superconducting gap and the pseudogap, respectively. These results imply that the revised phase diagram is likely to take place in high-temperature superconductors.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shvydky, Alex

This volume of LLE Review, covering October–December 2011, features “Crossed-Beam Energy Transfer in Direct-Drive Implosions” by I. V. Igumenshchev, W. Seka, D. H. Edgell, D. T. Michel, D. H. Froula, R. S. Craxton, R. Follett, J. H. Kelly, T. Z. Kosc, J. F. Myatt, T. C. Sangster, A. Shvydky, S. Skupsky, and C. Stoeckl (LLE); V. N. Goncharov and A. V. Maximov (LLE and Department of Mechanical Engineering, U. of Rochester); L. Divol and P. Michel (LLNL); and R. L. McCrory and D. D. Meyerhofer (LLE and Departments of Mechanical Engineering and Physics, U. of Rochester). In this article (p.more » 1), direct-drive–implosion experiments on the OMEGA laser [T. R. Boehly et al., Opt. Commun. 133, 495 (1995)] have shown discrepancies between simulations of the scattered (non-absorbed) light levels and measured ones that indicates the presence of a mechanism that reduces laser coupling efficiency by 10% to 20%. The authors attribute this degradation in laser coupling to crossed-beam energy transfer (CBET)— which is electromagnetically seeded—low-gain stimulated Brillouin scattering. CBET scatters energy from the central portion of the incoming light beam to outgoing light, reducing the laser absorption and hydrodynamic efficiency of implosions. One-dimensional hydrodynamic simulations including CBET show good agreement with all observables in implosion experiments on OMEGA. Three strategies to mitigate CBET and improve laser coupling are considered: the use of narrow beams, multicolor lasers, and higher-Z ablators. Experiments on OMEGA using narrow beams have demonstrated improvements in implosion performance.« less

Healing microstructures of experimental and natural fault gouge

NASA Astrophysics Data System (ADS)

Keulen, Nynke; Stünitz, Holger; Heilbronner, RenéE.

2008-06-01

The healing of fault gouge was studied by examining microstructures of naturally and experimentally produced granitoid fault rock. We performed deformation experiments on intact granitoid rock samples at T = 300-500°C, Pc = 500 MPa, and ? = 1.2 × 10-4 - 1.3 × 10-7 s-1 with 0.2 wt% H2O added. Healing experiments were carried out on deformed samples at T = 200-500°C, Pc = 500 MPa, for 4 h to 14 days under hydrostatic and nonhydrostatic conditions. The grain size distributions (GSD) of the deformed samples were quantified using the D> value (slope of log(frequency) -log(radius) of the GSD) for quartz and feldspar fault gouge. Healing causes a decrease in the D> value from >2.0 to ˜1.5. The time dependence of the D> decrease is described by a hydrostatic healing law of the form ΔD = D>(t) - Df = A · e(-λ·t). The results of the laboratory experiments were compared to three natural fault systems, (1) Nojima Fault Zone (Japan), (2) fault zones in the Black Forest (Germany), and (3) Orobic Thrust (Italian Alps). Natural and experimental gouges have similar D> values. Healing is only observed in monomineralic aggregates; polymineralic (i.e., mixed) fault gouges retain their high D> value after extended healing times because grain growth is inhibited. Healing under nonhydrostatic conditions is more rapid than hydrostatic healing. The low strain rates, which were measured during nonhydrostatic healing, are temperature-dependent and suggest that diffusive mass transfer processes take place during deformation. Thus, fault rocks at upper to midcrustal depth may deform by combined cataclasis and diffusive mass transfer.

The Top...is it There? A Survey of the CDF and D0 Experiments

DOE R&D Accomplishments Database

Tollestrup, A. V.

1994-12-01

This paper describes: (1) features that the top quark must have if it exists, and how those features are inferred from various experiments; (2) how top quarks may be produced; (3) what must be accomplished to directly establish that the top quark has been produced in an experiment. Relevant features of the CDF and D0 detectors are described, as are methods useful in a top-quark search for identifying and detecting various kinds of particles. The author reviews data found by both CDF and D0, and discusses differences between the detectors and the data found with each.

Gower Handbook of Training and Development. Second Edition.

ERIC Educational Resources Information Center

Prior, John, Ed.

This compilation of the knowledge and experience of 49 training and development professionals is a guide to the most important aspects of training and development (T&D), ranging from the environment in which it operates to detailed suggestions as to how it can be done. Contributors' notes appear first. Part 1 on the world of T&D contains seven…

Pitch discrimination as a function of the inter-stimulus interval: Evidence against a simple model of perceptual memory

NASA Astrophysics Data System (ADS)

Demany, Laurent; Montandon, Gaspard; Semal, Catherine

2003-04-01

A listener's ability to compare two sounds separated by a silent time interval T is limited by a sum of ``sensory noise'' and ``memory noise.'' The present work was intended to test a model according to which these two components of internal noise are independent and, for a given sensory continuum, the memory noise depends only on T. In three experiments using brief sounds (<80 ms), pitch discrimination performances were measured in terms of d' as a function of T (0.1-4 s) and a physical parameter affecting the amount of sensory noise (pitch salience). As T increased, d' first increased rapidly and then declined more slowly. According to the tested model, the relative decline of d' beyond the optimal value of T should have been slower when pitch salience was low (large amount of sensory noise) than when pitch salience was high (small amount of sensory noise). However, this prediction was disproved in each of the three experiments. It was also found, when a ``roving'' procedure was used, that the optimal value of T was markedly shorter for very brief tone bursts (6 sine cycles) than for longer tone bursts (30 sine cycles).

A Study of the Hadronic Production of $D^0$ and $$\\overline{D}\\,{^0}$$ Mesons: $$x_F$$ and $$p_t$$ Distributions (in Portuguese)

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Mello Neto, Joao Torres

Using a 250 Ge V hadron beam incident on thin targets foils of Be, Al, Cu and W, themore » $$x_F$$ and $$p_t$$ distributions of $D^0$ and $$\\bar{D}^0$$ were measured from Fermilab experiment E769 using the decay mode $$D^0 \\to K^- \\pi^+$$ and c.c. The measurements were made with the $$\\pi^-$$ induced sample, 607 ± 29 events. Fitting the $$x_F$$ distribution to (1- $$x_F)^{\\eta}$$ it was measured $$\\eta$$ = 3.86 ± 0.25 ± 0.10 for $$D0/\\bar{D}^0$$ , $$\\eta$$ = 3.89 ± 0.40 for $D^0$ and $$\\eta$$ = 3.74 ± 0.34 for $$\\bar{D}^0$$ • Fitting the $$p^2_t$$ distribuition to exp $$bp^2_t$$;, it was measured $b$ = 1.05 ± 0.06 ± 0.02 for $$DO/\\bar{D}^0$$ $b$ = 1.12 ± 0.09 for $D^0$ and $b$ = 1.00 ± 0.07 for $$\\bar{D}^0$$. The $$x_F$$ distribution is consistent with the perturbative QCD calculations.« less

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.

PubMed

Horikoshi, Momoko; Pasquali, Lorenzo; Wiltshire, Steven; Huyghe, Jeroen R; Mahajan, Anubha; Asimit, Jennifer L; Ferreira, Teresa; Locke, Adam E; Robertson, Neil R; Wang, Xu; Sim, Xueling; Fujita, Hayato; Hara, Kazuo; Young, Robin; Zhang, Weihua; Choi, Sungkyoung; Chen, Han; Kaur, Ismeet; Takeuchi, Fumihiko; Fontanillas, Pierre; Thuillier, Dorothée; Yengo, Loic; Below, Jennifer E; Tam, Claudia H T; Wu, Ying; Abecasis, Gonçalo; Altshuler, David; Bell, Graeme I; Blangero, John; Burtt, Noél P; Duggirala, Ravindranath; Florez, Jose C; Hanis, Craig L; Seielstad, Mark; Atzmon, Gil; Chan, Juliana C N; Ma, Ronald C W; Froguel, Philippe; Wilson, James G; Bharadwaj, Dwaipayan; Dupuis, Josee; Meigs, James B; Cho, Yoon Shin; Park, Taesung; Kooner, Jaspal S; Chambers, John C; Saleheen, Danish; Kadowaki, Takashi; Tai, E Shyong; Mohlke, Karen L; Cox, Nancy J; Ferrer, Jorge; Zeggini, Eleftheria; Kato, Norihiro; Teo, Yik Ying; Boehnke, Michael; McCarthy, Mark I; Morris, Andrew P

2016-05-15

To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional analyses, we identified seven distinct association signals at these four loci, each with allelic effects on T2D susceptibility that were homogenous across ancestry groups. By leveraging differences in the structure of linkage disequilibrium between diverse populations, and increased sample size, we localised the variants most likely to drive each distinct association signal. We demonstrated that integration of these genetic fine-mapping data with genomic annotation can highlight potential causal regulatory elements in T2D-relevant tissues. These analyses provide insight into the mechanisms through which T2D association signals are mediated, and suggest future routes to understanding the biology of specific disease susceptibility loci. © The Author 2016. Published by Oxford University Press.

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells

PubMed Central

Marca, Valeria La; Gianchecchi, Elena

2018-01-01

Type 1 diabetes (T1D) affects millions of people worldwide and is the prevalent form of all pediatric diabetes diagnoses. T1D is recognized to have an autoimmune etiology, since failure in specific self-tolerance mechanisms triggers immune reactions towards self-antigens and causes disease onset. Among all the different immunocytes involved in T1D etiopathogenesis, a relevant role of natural killer cells (NKs) is currently emerging. NKs represent the interface between innate and adaptive immunity; they intervene in the defense against infections and present, at the same time, typical features of the adaptive immune cells, such as expansion and generation of memory cells. Several recent studies, performed both in animal models and in human diabetic patients, revealed aberrations in NK cell frequency and functionality in the peripheral blood and in damaged tissues, suggesting their possible redirection towards affected tissues. NKs oscillate from a quiescent to an activated state through a delicate balance of activating and inhibitory signals transduced via surface receptors. Further accurate investigations are needed to elucidate the exact role of NKs in T1D, in order to develop novel immune-based therapies able to reduce the disease risk or delay its onset. PMID:29534427

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells.

PubMed

Marca, Valeria La; Gianchecchi, Elena; Fierabracci, Alessandra

2018-03-10

Type 1 diabetes (T1D) affects millions of people worldwide and is the prevalent form of all pediatric diabetes diagnoses. T1D is recognized to have an autoimmune etiology, since failure in specific self-tolerance mechanisms triggers immune reactions towards self-antigens and causes disease onset. Among all the different immunocytes involved in T1D etiopathogenesis, a relevant role of natural killer cells (NKs) is currently emerging. NKs represent the interface between innate and adaptive immunity; they intervene in the defense against infections and present, at the same time, typical features of the adaptive immune cells, such as expansion and generation of memory cells. Several recent studies, performed both in animal models and in human diabetic patients, revealed aberrations in NK cell frequency and functionality in the peripheral blood and in damaged tissues, suggesting their possible redirection towards affected tissues. NKs oscillate from a quiescent to an activated state through a delicate balance of activating and inhibitory signals transduced via surface receptors. Further accurate investigations are needed to elucidate the exact role of NKs in T1D, in order to develop novel immune-based therapies able to reduce the disease risk or delay its onset.

The profile of HLA-DRB1 alleles in Arabs with type 1 diabetes; meta-analyses.

PubMed

Hamzeh, A R; Nair, P; Al Ali, M T

2016-01-01

Genes from the HLA complex have a major contribution in type 1 diabetes (T1D), which results from an interplay between environmental and genetic factors. The latter can explain some of the geographic variability in T1D occurrence around the world. Of a particular importance in this regard are the HLA-DR, -DP and -DQ loci. Consequently, we aimed at elucidating the collective genetic profiles of various alleles relating to HLA-DRB1 and -DP in T1D patients throughout the Arab World using the tools of meta-analysis. As for HLA-DQA1 and DQB1 alleles; this analysis was completed and published previously (see Introduction). As a result of limited availability of relevant studies of the HLA-DP locus, only HLA-DRB1 alleles were tackled in this paper. Our study showed that significant increases in T1D risk resulted from harboring the alleles DRB1*03:01 and *04:05 (odds ratio 7.76 and 7.52, respectively). DRB1*04:01 and *04:02 were also predisposing for T1D in Arabs. Very strong evidence supported the protective effects of DRB1*10:01, *13:01, *15:02 and *16:01, with low heterogeneity and no publication bias. The results from the series of meta-analyses performed in this study help to complete the global genetic epidemiological map of T1D by providing statistically robust data from the Arab World. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Electrical Resistivity Measurement of Cu and Zn on the Pressure-Dependent Melting Boundary

NASA Astrophysics Data System (ADS)

Secco, R. A.; Ezenwa, I.; Yong, W.

2016-12-01

Understanding how the core cools through heat conduction and modelling the geodynamo requires knowledge of the thermal and electrical conductivity of solid and liquid Fe and its relevant alloys at high pressures. It has been proposed that electrical resistivity of a pure metal is constant along its P-dependent melting boundary (Stacey and Anderson, PEPI, 2001). If confirmed, this invariant behavior could serve as a practical tool for low P studies to assess electrical resistivity of Earth's core. Since Earth's inner core boundary (ICB) is a melting boundary of mainly Fe, measurements of electrical resistivity of Fe at the melting boundary, under any P, would serve as a proxy for the resistivity at the ICB. A revised treatment (Stacey and Loper, PEPI, 2007) accounted for s-d scattering in transition metals with unfilled d-bands and limited the proposal to metals with electrons of the same type in filled d-band metals. To test this proposal, we made high P, T measurements of electrical resistivity of d-band filled Cu and Zn in solid and liquid states. Experiments were carried out in a 1000 ton cubic anvil press up to 5 GPa and 300K above melting temperatures. Two thermocouples placed at opposite ends of the wire sample served as T probes as well as 4-wire resistance electrodes in a switched circuit. A polarity switch was used to remove any bias voltage measurement using thermocouple legs. Electron microprobe analyses were used to check the compositions of the recovered samples. The expected resistivity decrease with P and increase with T were found and comparisons with 1atm data are in very good agreement. Within the error of measurement, the resistivity values of Cu decrease along the melting boundary while Zn appears to support the hypothesis of constant resistivity along the melting boundary.

Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis.

PubMed

Kim, Ji Yeon; Park, Keon Jae; Hwang, Joo-Yeon; Kim, Gyu Hee; Lee, DaeYeon; Lee, Yoo Jeong; Song, Eun Hyun; Yoo, Min-Gyu; Kim, Bong-Jo; Suh, Young Ho; Roh, Gu Seob; Gao, Bin; Kim, Won; Kim, Won-Ho

2017-08-01

Non-alcoholic fatty liver disease (NAFLD) contributes to impaired glucose tolerance, leading to type 2 diabetes (T2D); however, the precise mechanisms and target molecules that are involved remain unclear. Activating transcription factor 3 (ATF3) is associated with β-cell dysfunction that is induced by severe stress signals in T2D. We aimed to explore the exact functional role of ATF3 as a mechanistic link between hepatic steatosis and T2D development. Zucker diabetic fatty (ZDF) rats were utilized for animal experiments. An in vivo-jetPEI siRNA delivery system against ATF3 was used for loss-of-function experiments. We analyzed the baseline cross-sectional data derived from the biopsy-proven NAFLD registry (n=322). Human sera and liver tissues were obtained from 43 patients with biopsy-proven NAFLD and from seven healthy participants. ATF3 was highly expressed in the livers of ZDF rats and in human participants with NAFLD and/or T2D. Insulin resistance and hepatic steatosis were associated with increased ATF3 expression and decreased fatty acid oxidation via mitochondrial dysfunction and were attenuated by in vivo ATF3 silencing. Knockdown of ATF3 also ameliorated glucose intolerance, impaired insulin action, and inflammatory responses in ZDF rats. In patients with NAFLD and/or T2D, a significant positive correlation was observed between hepatic ATF3 expression and surrogate markers of T2D, mitochondrial dysfunction, and macrophage infiltration. Increased hepatic ATF3 expression is closely associated with hepatic steatosis and incident T2D; therefore, ATF3 may serve as a potential therapeutic target for NAFLD and hepatic steatosis-induced T2D. Hepatic activating transcription factor 3 (ATF3) may play an important role in oxidative stress-mediated hepatic steatosis and the development of type 2 diabetes (T2D) in a Zucker diabetic fatty (ZDF) rat model and in human patients with non-alcoholic fatty liver disease (NAFLD). Therefore, ATF3 may be a useful biomarker for predicting the progression of NAFLD and the development of T2D. Furthermore, given the significant association between hepatic ATF3 expression and both hepatic steatosis and impaired glucose homeostasis, in vivo ATF3 silencing may be a potential central strategy for preventing and managing NAFLD and T2D. Copyright © 2017 European Association for the Study of the Liver. All rights reserved.

Sleep in Type 1 Diabetes: Implications for Glycemic Control and Diabetes Management.

PubMed

Perez, Katia M; Hamburger, Emily R; Lyttle, Morgan; Williams, Rodayne; Bergner, Erin; Kahanda, Sachini; Cobry, Erin; Jaser, Sarah S

2018-02-05

To highlight recent findings from studies of sleep in type 1 diabetes (T1D), with a focus on the role of sleep in self-management, the cognitive and psychosocial outcomes related to sleep disturbances, and factors associated with sleep disturbances specific to T1D. People with T1D experience higher rates of sleep disturbances than people without diabetes, and these disturbances have negative implications for glycemic control and diabetes management, as well as psychosocial and cognitive outcomes. Inconsistent sleep timing (bedtime and wake time) has emerged as a potential target for interventions, as variability in sleep timing has been linked with poorer glycemic control and adherence to treatment. Sleep-promoting interventions and new diabetes technology have the potential to improve sleep in people with T1D. Sleep is increasingly considered a critical factor in diabetes management, but more multi-method and longitudinal research is needed. We emphasize the importance of sufficient and consistent sleep for people with T1D, and the need for providers to routinely assess sleep among patients with T1D.

Canadian Potential Healthcare and Societal Cost Savings from Consumption of Pulses: A Cost-Of-Illness Analysis

PubMed Central

Abdullah, Mohammad M. H.; Marinangeli, Christopher P. F.; Jones, Peter J. H.; Carlberg, Jared G.

2017-01-01

Consumption of dietary pulses, including beans, peas and lentils, is recommended by health authorities across jurisdictions for their nutritional value and effectiveness in helping to prevent and manage major diet-related illnesses of significant socioeconomic burden. The aim of this study was to estimate the potential annual healthcare and societal cost savings relevant to rates of reduction in complications from type 2 diabetes (T2D) and incidence of cardiovascular disease (CVD) following a low glycemic index (GI) or high fiber diet that includes pulses, or 100 g/day pulse intake in Canada, respectively. A four-step cost-of-illness analysis was conducted to: (1) estimate the proportions of individuals who are likely to consume pulses; (2) evaluate the reductions in established risk factors for T2D and CVD; (3) assess the percent reduction in incidences or complications of the diseases of interest; and (4) calculate the potential annual savings in relevant healthcare and related costs. A low GI or high fiber diet that includes pulses and 100 g/day pulse intake were shown to potentially yield Can$6.2 (95% CI $2.6–$9.9) to Can$62.4 (95% CI $26–$98.8) and Can$31.6 (95% CI $11.1–$52) to Can$315.5 (95% CI $110.6–$520.4) million in savings on annual healthcare and related costs of T2D and CVD, respectively. Specific provincial/territorial analyses suggested annual T2D and CVD related cost savings that ranged from up to Can$0.2 million in some provinces to up to Can$135 million in others. In conclusion, with regular consumption of pulse crops, there is a potential opportunity to facilitate T2D and CVD related socioeconomic cost savings that could be applied to Canadian healthcare or re-assigned to other priority domains. Whether these potential cost savings will be offset by other healthcare costs associated with longevity and diseases of the elderly is to be investigated over the long term. PMID:28737688

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

PubMed Central

Hayes, Colleen Elizabeth; Hubler, Shane L.; Moore, Jerott R.; Barta, Lauren E.; Praska, Corinne E.; Nashold, Faye E.

2015-01-01

This review summarizes and integrates research on vitamin D and CD4+ T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. A deep understanding of molecular mechanisms relevant to gene–environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. Evidence for CD4+ T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4+ T lymphocytes is summarized to support the thesis that calcitriol is sunlight’s main protective signal transducer in autoimmune disease risk. Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3+CD4+ T-regulatory cell and CD4+ T-regulatory cell type 1 (Tr1) cell functions, and a Th1–Tr1 switch. The proposed Th1–Tr1 switch appears to bridge two stable, self-reinforcing immune states, pro- and anti-inflammatory, each with a characteristic gene regulatory network. The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell–cell interactions, and soluble mediators and respond in a biologically appropriate manner. Finally, unanswered questions and potentially informative future research directions are highlighted to speed delivery of etiology-based strategies to reduce autoimmune disease. PMID:25852682

Atomic Processes Relevant to Antimatter Fuel Production and Storage

DTIC Science & Technology

1994-05-31

TO ANTIMATTER FUEL ’ |PRODUCTION AND STORAGE DTIC S nELECTE JUL0 11994 D FINAL REPORT F * 31 MAY 1994 I * Prepared by: J.B.A. Mitchell Dept. of Physics...Atomic Processes Relevant to Antimatter Fuel Production and Storage 12. PERSONAL AUTHOR(S) J.B.A. Mitchell I 3a. TYPE JFRE qT 113b. TIME COVERED 114... antimatter production, this investigation did shed a great deal of light on the recombination process in general and so is worthy of inclusion in this report

A Radiation Laboratory Curriculum Development at Western Kentucky University

NASA Astrophysics Data System (ADS)

Barzilov, Alexander P.; Novikov, Ivan S.; Womble, Phil C.

2009-03-01

We present the latest developments for the radiation laboratory curriculum at the Department of Physics and Astronomy of Western Kentucky University. During the last decade, the Applied Physics Institute (API) at WKU accumulated various equipment for radiation experimentation. This includes various neutron sources (computer controlled d-t and d-d neutron generators, and isotopic 252 Cf and PuBe sources), the set of gamma sources with various intensities, gamma detectors with various energy resolutions (NaI, BGO, GSO, LaBr and HPGe) and the 2.5-MeV Van de Graaff particle accelerator. XRF and XRD apparatuses are also available for students and members at the API. This equipment is currently used in numerous scientific and teaching activities. Members of the API also developed a set of laboratory activities for undergraduate students taking classes from the physics curriculum (Nuclear Physics, Atomic Physics, and Radiation Biophysics). Our goal is to develop a set of radiation laboratories, which will strengthen the curriculum of physics, chemistry, geology, biology, and environmental science at WKU. The teaching and research activities are integrated into real-world projects and hands-on activities to engage students. The proposed experiments and their relevance to the modern status of physical science are discussed.

Integral experiments on thorium assemblies with D-T neutron source

NASA Astrophysics Data System (ADS)

Liu, Rong; Yang, Yiwei; Feng, Song; Zheng, Lei; Lai, Caifeng; Lu, Xinxin; Wang, Mei; Jiang, Li

2017-09-01

To validate nuclear data and code in the neutronics design of a hybrid reactor with thorium, integral experiments in two kinds of benchmark thorium assemblies with a D-T fusion neutron source have been performed. The one kind of 1D assemblies consists of polyethylene and depleted uranium shells. The other kind of 2D assemblies consists of three thorium oxide cylinders. The capture reaction rates, fission reaction rates, and (n, 2n) reaction rates in 232Th in the assemblies are measured by ThO2 foils. The leakage neutron spectra from the ThO2 cylinders are measured by a liquid scintillation detector. The experimental uncertainties in all the results are analyzed. The measured results are compared to the calculated ones with MCNP code and ENDF/B-VII.0 library data.

Eisenstein Series and String Thresholds

NASA Astrophysics Data System (ADS)

Obers, N. A.; Pioline, B.

We investigate the relevance of Eisenstein series for representing certain G()-invariant string theory amplitudes which receive corrections from BPS states only. G() may stand for any of the mapping class, T-duality and U-duality groups Sl(d,(), SO(d,d,() or Ed+1(d+1)(() respectively. Using G()-invariant mass formulae, we construct invariant modular functions on the symmetric space K\\G() of non-compact type, with K the maximal compact subgroup of G(), that generalize the standard non-holomorphic Eisenstein series arising in harmonic analysis on the fundamental domain of the Poincaré upper half-plane. Comparing the asymptotics and eigenvalues of the Eisenstein series under second order differential operators with quantities arising in one- and g-loop string amplitudes, we obtain a manifestly T-duality invariant representation of the latter, conjecture their non-perturbative U-duality invariant extension, and analyze the resulting non-perturbative effects. This includes the R4 and R4H4g-4 couplings in toroidal compactifications of M-theory to any dimension D>= 4 and D>= 6 respectively.

Scorpion venom complexity fractal analysis. Its relevance for comparing venoms.

PubMed

D'Suze, Gina; Sevcik, Carlos

2010-12-07

We analyzed the venom elution pattern of 15 scorpions species. Data were scanned at 1 Hz and stored digitally. Approximate fractal dimension (D) [Sevcik (1998)] was calculated for minutes 0-60 of the elutions. D was calculated for either the whole time range, or calculated using a window of 500 points, which was displaced by one time increment recursively, and stored [(t(i),D(i)) sets]. We avoid the term complexity as much as possible since defining complexity is difficult; instead we propose the term contortedness and represent it by the variable Q=D-1. To compare venom contortednesses of different species, a phase plot with their (t(i),Q(i)) sets was constructed and determination coefficient (d(s)) were calculated squaring the Spearman rank correlation coefficient. (t(i),Q(i)) sets of several elutions of the same species were averaged and compared with other species finding that some were amazingly similar (Tityus clathratus vs Tityus caripitensis, d(s) = 0.813). Tityus discrepans was similar to 6 of 8 species of the same genus (d(s) ranging from 0.23 to 0.49), and also similar to Centruroides gracilis and Chactas laevipes (d(s) 0.54 and 0.49, respectively). Serendipitously,T. discrepans was chosen many years ago to produce anti-Tityus antivenom in Venezuela; perhaps the clinical success in neutralizing the venom of the other known Venezuelan Tityus, stems from the mimetism of this venom with the remaining species' venom. Copyright © 2010 Elsevier Ltd. All rights reserved.

Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells.

PubMed

Montanez-Sauri, Sara I; Sung, Kyung Eun; Berthier, Erwin; Beebe, David J

2013-03-01

During breast carcinoma progression, the three-dimensional (3D) microenvironment is continuously remodeled, and changes in the composition of the extracellular matrix (ECM) occur. High throughput screening platforms have been used to decipher the complexity of the microenvironment and to identify ECM components responsible for cancer progression. However, traditional screening platforms are typically limited to two-dimensional (2D) cultures, and often exclude the influence of ECM and stromal components. In this work, a system that integrates 3-dimensional cell culture techniques with an automated microfluidic platform was used to create a new ECM screening platform that cultures cells in more physiologically relevant 3D in vitro microenvironments containing stromal cells and different ECM molecules. This new ECM screening platform was used to culture T47D breast carcinoma cells in mono- and co-culture with human mammary fibroblasts (HMF) with seven combinations of three different ECM proteins (collagen, fibronectin, laminin). Differences in the morphology of T47D clusters, and the proliferation of T47D cells were found in ECM compositions rich in fibronectin or laminin. In addition, an MMP enzyme activity inhibition screening showed the capabilities of the platform for small molecule screening. The platform presented in this work enables screening for the effects of matrix and stromal compositions and show promises for providing new insights in the identification of key ECM components involved in breast cancer.

High-field magnetotransport studies in microstructures of Yb2Pt2Pb

NASA Astrophysics Data System (ADS)

Helm, Toni; Balakirev, Fedor; Rosner, Helge; Bachmann, Maja; Moll, Philip

Yb2Pt2Pb (YPP) is a strongly frustrated Shastry Sutherland (SSL) Anitiferromagnet with a a ordering temperature of TN = 2 K. The antiferromagnetic (AF) order is comprised of two AF sublattices built from dimers of Yb3+ ions in the ab planes. Unlike other quantum magnets, YPP is a highly conductive metal. Recently, exotic quantum effects were reported from neutron scattering experiments that indicate charge-orbital separation along the c axis, similar to quasi-1D materials. To study the influence of YPP's rich magnetic structure on the anisotropic charge transport, we fabricated micron-sized transport devices from single crystalline YPP by Focused Ion Beam etching. This technique enables high-precision magnetotransport measurements along the most relevant lattice directions in magnetic fields of up to 65 T. Our findings reveal insights on the electronic structure of YPP.

Solid state crystal physics at very low temperatures

NASA Technical Reports Server (NTRS)

Davis, W.; Krack, K.; Richard, J. P.; Weber, J.

1980-01-01

The mechanical dissipation (Q) and resonant frequency of a 15 kg silicon crystal were measured at cryogenic temperatures. In the experiment described, temperature control was incorporated to reduce the time derivative of the temperature. The results of the Q measurements with and without this temperature control are quite different. Measurements of the resonant frequency of the fundamental longitudinal mode of the silicon crystal from 6 to 300 Kelvin are presented and discussed with respect to temperature, df/dT. It is observed that frequency increases as temperature decreases down to about 16 Kelvin, i.e. dt/dT is negative. However, below this temperature the frequency decreases as temperature decreases, i.e. dt/dT is positive. It is suggested that this behavior is related to the coefficient of thermal contraction of silicon, which changes sign at 18 Kelvin. Continuation of these experiments to 20 mK is discussed.

Observation of exchange of micropore water in cement pastes by two-dimensional T(2)-T(2) nuclear magnetic resonance relaxometry.

PubMed

Monteilhet, L; Korb, J-P; Mitchell, J; McDonald, P J

2006-12-01

The first detailed analysis of the two-dimensional (2D) NMR T(2)-T(2) exchange experiment with a period of magnetization storage between the two T(2) relaxation encoding periods (T(2)-store-T(2)) is presented. It is shown that this experiment has certain advantages over the T(1)-T(2) variant for the quantization of chemical exchange. New T(2)-store-T(2) 2D 1H NMR spectra of the pore water within white cement paste are presented. Based on these spectra, the exchange rate of water between the two smallest porosity reservoirs is estimated for the first time. It is found to be of the order of 5 ms{-1}. Further, a careful estimate of the pore sizes of these reservoirs is made. They are found to be of the order of 1.4 nm and 10-30 nm , respectively. A discussion of the results is developed in terms of possible calcium silicate hydrate products. A water diffusion coefficient inferred from the exchange rate and the cement particle size is found to compare favorably with the results of molecular-dynamics simulations to be found in the literature.

Managing the Quality of Experience in the Multimedia Internet of Things: A Layered-Based Approach †

PubMed Central

Floris, Alessandro; Atzori, Luigi

2016-01-01

This paper addresses the issue of evaluating the Quality of Experience (QoE) for Internet of Things (IoT) applications, with particular attention to the case where multimedia content is involved. A layered IoT architecture is firstly analyzed to understand which QoE influence factors have to be considered in relevant application scenarios. We then introduce the concept of Multimedia IoT (MIoT) and define a layered QoE model aimed at evaluating and combining the contributions of each influence factor to estimate the overall QoE in MIoT applications. Finally, we present a use case related to the remote monitoring of vehicles during driving practices, which is used to validate the proposed layered model, and we discuss a second use case for smart surveillance, to emphasize the generality of the proposed framework. The effectiveness in evaluating classes of influence factors separately is demonstrated. PMID:27918437

Managing the Quality of Experience in the Multimedia Internet of Things: A Layered-Based Approach.

PubMed

Floris, Alessandro; Atzori, Luigi

2016-12-02

This paper addresses the issue of evaluating the Quality of Experience (QoE) for Internet of Things (IoT) applications, with particular attention to the case where multimedia content is involved. A layered IoT architecture is firstly analyzed to understand which QoE influence factors have to be considered in relevant application scenarios. We then introduce the concept of Multimedia IoT (MIoT) and define a layered QoE model aimed at evaluating and combining the contributions of each influence factor to estimate the overall QoE in MIoT applications. Finally, we present a use case related to the remote monitoring of vehicles during driving practices, which is used to validate the proposed layered model, and we discuss a second use case for smart surveillance, to emphasize the generality of the proposed framework. The effectiveness in evaluating classes of influence factors separately is demonstrated.

A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage.

PubMed

Juras, Vladimir; Bohndorf, Klaus; Heule, Rahel; Kronnerwetter, Claudia; Szomolanyi, Pavol; Hager, Benedikt; Bieri, Oliver; Zbyn, Stefan; Trattnig, Siegfried

2016-06-01

To assess the clinical relevance of T2 relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T2-mapping. Thirteen volunteers and ten patients with focal cartilage lesions were included in this prospective study. All subjects underwent 3-Tesla MRI consisting of a multi-echo multi-slice spin-echo sequence (CPMG) as a reference method for T2 mapping, and 3D TESS with the same geometry settings, but variable acquisition times: standard (TESSs 4:35min) and quick (TESSq 2:05min). T2 values were compared in six different regions in the femoral and tibial cartilage using a Wilcoxon signed ranks test and the Pearson correlation coefficient (r). The local ethics committee approved this study, and all participants gave written informed consent. The mean quantitative T2 values measured by CPMG (mean: 46±9ms) in volunteers were significantly higher compared to those measured with TESS (mean: 31±5ms) in all regions. Both methods performed similarly in patients, but CPMG provided a slightly higher difference between lesions and native cartilage (CPMG: 90ms→61ms [31%],p=0.0125;TESS 32ms→24ms [24%],p=0.0839). 3D-TESS provides results similar to those of a conventional multi-echo spin-echo sequence with many benefits, such as shortening of total acquisition time and insensitivity to B1 and B0 changes. • 3D-TESS T 2 mapping provides clinically comparable results to CPMG in shorter scan-time. • Clinical and investigational studies may benefit from high temporal resolution of 3D-TESS. • 3D-TESS T 2 values are able to differentiate between healthy and damaged cartilage.

Final Report for Research in High Energy Physics (University of Hawaii)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Browder, Thomas E.

2013-08-31

Here we present a final report for the DOE award for the University of Hawaii High Energy Physics Group (UHHEPG) for the period from December 1, 2009 to May 31, 2013 (including a period of no-cost extension). The high energy physics (HEP) group at the University of Hawaii (UH) has been engaged in experiments at the intensity frontier studying flavor physics (Task A: Belle, Belle-II and Task B: BES) and neutrinos (Task C: SuperK, LBNE, Double Chooz, DarkSide, and neutrino R\\&D). On the energy frontier, new types of pixel detectors were developed for upgrades of the ATLAS experiment at themore » LHC (Task D). On the cosmic frontier, there were investigations of ultra high-energy neutrino astrophysics and the highest energy cosmic rays using special radio detection techniques (Task E: AMBER, ANITA R\\&D) and results of the analysis of ANITA data. In addition, we have developed new types of sophisticated and cutting edge instrumentation based on novel ``oscilloscope on a chip'' electronics (Task F). Theoretical physics research (Task G) is phenomenologically oriented and has studied experimental consequences of existing and proposed new theories relevant to the energy, cosmic and intensity frontiers. The senior investigators for proposal were T. E. Browder (Task A), F. A. Harris (Task B), P. Gorham (Task E), J. Kumar (Task G), J. Maricic (Task C), J. G. Learned (Task C), S. Pakvasa (Task G), S. Parker (Task D), S. Matsuno (Task C), X. Tata (Task G) and G. S. Varner (Tasks F, A, E).« less

First finding of Trypanosoma cruzi II in vampire bats from a district free of domestic vector-borne transmission in Northeastern Argentina.

PubMed

Argibay, Hernán D; Orozco, M Marcela; Cardinal, M Victoria; Rinas, Miguel A; Arnaiz, María; Mena Segura, Carlos; Gürtler, Ricardo E

2016-09-01

Establishing the putative links between sylvatic and domestic transmission cycles of Trypanosoma cruzi, the etiological agent of Chagas disease, is of public health relevance. We conducted three surveys to assess T. cruzi infection in wild mammals from a rural and a preserved area in Misiones Province, Northeastern Argentina, which had recently been declared free of vector- and blood-borne transmission of human T. cruzi infection. A total of 200 wild mammals were examined by xenodiagnosis (XD) and/or polymerase chain reaction (PCR) amplification of the hyper-variable region of kinetoplast DNA minicircles of T. cruzi (kDNA-PCR). The overall prevalence of T. cruzi infection was 8%. Nine (16%) of 57 Didelphis albiventris opossums and two (7%) of 29 Desmodus rotundus vampire bats were positive by both XD and kDNA-PCR. Additionally, one D. rotundus positive for T. cruzi by kDNA-PCR tested positive by satellite-DNA-PCR (SAT-DNA-PCR). The T. cruzi-infected bats were captured indoors and in the yard of a vacant dwelling. All D. albiventris were infected with TcI and both XD-positive D. rotundus by TcII. Fifty-five opossum cubs within the marsupium were negative by XD. The mean infectiousness to the vector was 62% in D. albiventris and 50% in D. rotundus. Mice experimentally infected with a parasite isolate from a vampire bat displayed lesions typically caused by T. cruzi. Our study documents the presence of the genotype TcII in a sylvatic host for the first time in Argentina, and the occurrence of two transmission cycles of T. cruzi in a district free of domestic vector-borne transmission.

Effect of transportation duration of 1-day-old chicks on postplacement production performances and pododermatitis of broilers up to slaughter age.

PubMed

Bergoug, H; Guinebretière, M; Tong, Q; Roulston, N; Romanini, C E B; Exadaktylos, V; Berckmans, D; Garain, P; Demmers, T G M; McGonnell, I M; Bahr, C; Burel, C; Eterradossi, N; Michel, V

2013-12-01

This experiment studied the effect of transportation duration of 1-d-old chicks on dehydration, mortality, production performance, and pododermatitis during the growout period. Eggs from the same breeder flock (Ross PM3) were collected at 35, 45, and 56 wk of age, for 3 successive identical experiments. In each experiment, newly hatched chicks received 1 of 3 transportation duration treatments from the hatchery before placement in the on-site rearing facility: no transportation corresponding to direct placement in less than 5 min (T00), or 4 (T04) or 10 h (T10) of transportation. The chicks were housed in 35-m(2) pens (650 birds each) and reared until 35 d old. Hematocrit and chick BW were measured on sample chicks before and after transportation. During the growout period, bird weight, feed uptake, and feed conversion ratio were measured weekly until slaughter. Transportation duration affected BW; T00 groups had a significantly higher BW than T04 and T10 transported birds but this effect lasted only until d 21. No clear effect on hematocrit, feed uptake, feed conversion ratio, or mortality was observed for birds transported up to 10 h. The decrease in weight in T10 birds was associated with less severe pododermatitis. Increasing age of the breeder flock was correlated with reduced egg fertility and hatchability, and also with higher quality and BW of hatched chicks. Chicks from older breeders also exhibited reduced mortality during the growout period.

Dépression et niveau de fardeau chez les aidants familiaux des sujets déments en Tunisie

PubMed Central

Ben Thabet, Jihène; Jaoua, Feriel; Charfi, Nada; Zouari, Lobna; Zouari, Nasreddine; Maalej, Mohamed

2011-01-01

Introduction La démence peut retentir lourdement sur les aidants familiaux du patient. Les objectifs de notre étude étaient de déterminer le niveau de fardeau et de la dépression chez les aidants familiaux de sujets déments, et d'identifier les facteurs associés à un niveau de fardeau élevé. Méthodes Il s'agissait d'une enquête auprès de 65 aidants tunisiens. Les niveaux de fardeau et de la dépression ont été évalués par, respectivement, l'inventaire de Zarit et l’échelle de Beck. Résultats Le taux des aidants qui avaient un niveau de fardeau élevé était de 52,3 %. Une dépression modérée ou sévère a été relevée chez 46,2 %. Un niveau de fardeau élevé était corrélé, du côté de l'aidant, avec le niveau socio-économique moyen à élevé, la cohabitation avec le patient, le fait d’être son conjoint, la réduction des activités quotidiennes et la sévérité de la dépression, et, du côté du dément, avec l'agressivité. Conclusion Les facteurs corrélés à un niveau de fardeau élevé orientent vers les cibles d'intervention et sont susceptibles d’être améliorés par la prise en charge, ce qui contribuerait à alléger la détresse des aidants. PMID:22384291

The effect of Brazilian propolis on serum thyroid hormones in broilers reared under chronic heat stress

USDA-ARS?s Scientific Manuscript database

This experiment evaluated the effect of dietary supplement with green Brazilian propolis on serum thyroxin (T4) and tri-iodothyronine (T3) levels in broiler chickens exposed to chronic heat stress for 4 wks (from 15 to 42 d of age). Five hundred and four 15-d-old, male broiler chickens (Ross 708) w...

Improving School Experiences for Adolescents with Type 1 Diabetes

ERIC Educational Resources Information Center

Kise, Saori S.; Hopkins, Amanda; Burke, Sandra

2017-01-01

Background: Diabetes mellitus (diabetes) is one of the most common metabolic diseases in children worldwide and the incidence of type 1 diabetes (T1D) is growing. T1D is complicated to manage and adolescents with diabetes face unique, age-specific challenges. The purpose of this article is to discuss ways in which schools can create a positive…

Improving GEOS-5 seven day forecast skill by assimilation of quality controlled AIRS temperature profiles

NASA Astrophysics Data System (ADS)

Susskind, J.; Rosenberg, R. I.

2016-12-01

The GEOS-5 Data Assimilation System (DAS) generates a global analysis every six hours by combining the previous six hour forecast for that time period with contemporaneous observations. These observations include in-situ observations as well as those taken by satellite borne instruments, such as AIRS/AMSU on EOS Aqua and CrIS/ATMS on S-NPP. Operational data assimilation methodology assimilates observed channel radiances Ri for IR sounding instruments such as AIRS and CrIS, but only for those channels i in a given scene whose radiances are thought to be unaffected by clouds. A limitation of this approach is that radiances in most tropospheric sounding channels are affected by clouds under partial cloud cover conditions, which occurs most of the time. The AIRS Science Team Version-6 retrieval algorithm generates cloud cleared radiances (CCR's) for each channel in a given scene, which represent the radiances AIRS would have observed if the scene were cloud free, and then uses them to determine quality controlled (QC'd) temperature profiles T(p) under all cloud conditions. There are potential advantages to assimilate either AIRS QC'd CCR's or QC'd T(p) instead of Ri in that the spatial coverage of observations is greater under partial cloud cover. We tested these two alternate data assimilation approaches by running three parallel data assimilation experiments over different time periods using GEOS-5. Experiment 1 assimilated all observations as done operationally, Experiment 2 assimilated QC'd values of AIRS CCRs in place of AIRS radiances, and Experiment 3 assimilated QC'd values of T(p) in place of observed radiances. Assimilation of QC'd AIRS T(p) resulted in significant improvement in seven day forecast skill compared to assimilation of CCR's or assimilation of observed radiances, especially in the Southern Hemisphere Extra-tropics.

Guide to Canadian Aerospace-Related Industries

DTIC Science & Technology

1990-08-01

Quebec PLANT SIZE: 28,700 sq ft Canada H4L 4X8 EXPERIENCE: Barringer experience is worldwide. Recent R &D clients Plan t include Transport Canada, Revenue...Products, Ampheno Canada, ard J R Longts!affe"tel: (604) 530-2324 Fax: (604) 530-6242 CAPABILITY: Bruce D Vallillee Electronics Ltd, Marketing Consultants...Helicopters) BRISTOL AEROSPACE Ltd Instrumentation R &O (Helicopters) CANADIAN HELICOPTERS Ltd Quality Assurance Programs BRUCE D VALLILLEE R &O

The Extraction of 3D Shape from Texture and Shading in the Human Brain

PubMed Central

Georgieva, Svetlana S.; Todd, James T.; Peeters, Ronald

2008-01-01

We used functional magnetic resonance imaging to investigate the human cortical areas involved in processing 3-dimensional (3D) shape from texture (SfT) and shading. The stimuli included monocular images of randomly shaped 3D surfaces and a wide variety of 2-dimensional (2D) controls. The results of both passive and active experiments reveal that the extraction of 3D SfT involves the bilateral caudal inferior temporal gyrus (caudal ITG), lateral occipital sulcus (LOS) and several bilateral sites along the intraparietal sulcus. These areas are largely consistent with those involved in the processing of 3D shape from motion and stereo. The experiments also demonstrate, however, that the analysis of 3D shape from shading is primarily restricted to the caudal ITG areas. Additional results from psychophysical experiments reveal that this difference in neuronal substrate cannot be explained by a difference in strength between the 2 cues. These results underscore the importance of the posterior part of the lateral occipital complex for the extraction of visual 3D shape information from all depth cues, and they suggest strongly that the importance of shading is diminished relative to other cues for the analysis of 3D shape in parietal regions. PMID:18281304

Determination of a transient heat transfer property of acrylic using thermochromic liquid crystals

NASA Technical Reports Server (NTRS)

Heidmann, James D.

1994-01-01

An experiment was performed to determine a transient heat transfer property of acrylic. The experiment took advantage of the known analytical solution for heat conduction in a homogeneous semi-infinite solid with a constant surface heat flux. Thermochromic liquid crystals were used to measure the temperature nonintrusively. The relevant property in this experiment was the transient thermal conduction coefficient h(sub t), which is the square root of the product of density p, specific heat c(sub p), and thermal conductivity k (i.e., square root of pc(sub p)k). A value of 595.6 W square root of s/sq m K was obtained for h(sub t), with a standard deviation of 5.1 W square root of s/sq m K. Although there is no generally accepted value for h(sub t), a commonly used one is 580 W square root of s/sq m K, which is almost 3 percent less than the h(sub t) value obtained in this experiment. Since these results were highly repeatable and since there is no definitive value for h(sub t), the new value is recommended for future use.

Analysis of a Non-Developing Tropical Circulation System During the Tropical Cyclone Structure (TCS08) Field Experiment

DTIC Science & Technology

2009-12-01

Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaigns (T- PARC ). Aircraft dropwindsondes, special ELDORA radar observations...systems within TCS025 at 2030 UTC 24 August 2008. D. ELDORA BACKGROUND For the combined TCS08 and T- PARC field experiment, the ELDORA radar was...SUBJECT TERMS Electra Doppler Radar (ELDORA), Tropical Cyclone Structure (TCS08), TCS08, Tropical Cyclone Formation, Tropical Circulation System

Characteristics of the Hadronic Production of the $$D^{*\\pm}$$ Meson (in Portuguese)

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Miranda, Jussara Marques

The Fermilab experiment E769, a 250 GeV /c tagged hadron beam incident on thin target foils of Be, Al,Cu, and W, measured themore » $$X_F$$ and $$p^2_t$$ distributions of $$D^{*\\pm}$$ through the decay mode$$D^{*\\pm} \\to D^0 \\pi^+, D^0 \\to K^- \\pi^+$$. Fitting the distributions to the form $$A(1 - X_F)^n$$ and $$B exp(-bp^2_t)$$, we determined $n$ - 3.84 ± 0.20 ± 0.06 and $b$ = 0. 7 48 ± 0.034 ± 0.009, respectively. We observe no significant lea.ding particle ef.~ct suggested by earlier experiments. The dependence of the total cross section on the atomic mass number was determined to be $$A^{0.98 \\pm 0,05 \\pm 0.04}$$ . The measurements were based on 351 ± 16 fully reconstructed $$D^{*\\pm}$$ mesons induced by a $$\\pi^{\\pm}$$ and $$K^{\\pm}$$ beam. This is the gest available sample of hadroproduced $$D^{*\\pm}$$.« less

CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.

PubMed

Frazer, Lauren C; Sullivan, Jeanne E; Zurenski, Matthew A; Mintus, Margaret; Tomasak, Tammy E; Prantner, Daniel; Nagarajan, Uma M; Darville, Toni

2013-10-15

Resolution of Chlamydia genital tract infection is delayed in the absence of MyD88. In these studies, we first used bone marrow chimeras to demonstrate a requirement for MyD88 expression by hematopoietic cells in the presence of a wild-type epithelium. Using mixed bone marrow chimeras we then determined that MyD88 expression was specifically required in the adaptive immune compartment. Furthermore, adoptive transfer experiments revealed that CD4(+) T cell expression of MyD88 was necessary for normal resolution of genital tract infection. This requirement was associated with a reduced ability of MyD88(-/-)CD4(+) T cells to accumulate in the draining lymph nodes and genital tract when exposed to the same inflammatory milieu as wild-type CD4(+) T cells. We also demonstrated that the impaired infection control we observed in the absence of MyD88 could not be recapitulated by deficiencies in TLR or IL-1R signaling. In vitro, we detected an increased frequency of apoptotic MyD88(-/-)CD4(+) T cells upon activation in the absence of exogenous ligands for receptors upstream of MyD88. These data reveal an intrinsic requirement for MyD88 in CD4(+) T cells during Chlamydia infection and indicate that the importance of MyD88 extends beyond innate immune responses by directly influencing adaptive immunity.

Quality of Life of College Students Living With Type 1 Diabetes: A Qualitative View.

PubMed

Fredette, Judy; Mawn, Barbara; Hood, Korey; Fain, James

2016-12-01

The purpose of this phenomenological qualitative study was to examine the quality of life among college students living with Type 1 diabetes (T1D). Inclusion criteria included age 18 to 24, current college student, and a diagnosis of T1D for at least 1 year. Semi-structured interviews were conducted, in-person and by phone. During these interviews, college students shared stories of living with T1D and its impact on their quality of life. Three major themes emerged, which included "planning ahead," "thinking positive," and "seeking support." These findings provide a better understanding of the transitional experience of living with T1D and the impact on perceived quality of life while attending college. Techniques and strategies aimed at the enhancement of perceived quality of life for college students living with T1D were identified. These findings will provide valuable insight for professionals working with this population. © The Author(s) 2016.

Transcultural Endocrinology: Adapting Type-2 Diabetes Guidelines on a Global Scale.

PubMed

Nieto-Martínez, Ramfis; González-Rivas, Juan P; Florez, Hermes; Mechanick, Jeffrey I

2016-12-01

Type-2 diabetes (T2D) needs to be prevented and treated effectively to reduce its burden and consequences. White papers, such as evidence-based clinical practice guidelines (CPG) and their more portable versions, clinical practice algorithms and clinical checklists, may improve clinical decision-making and diabetes outcomes. However, CPG are underused and poorly validated. Protocols that translate and implement these CPG are needed. This review presents the global dimension of T2D, details the importance of white papers in the transculturalization process, compares relevant international CPG, analyzes cultural variables, and summarizes translation strategies that can improve care. Specific protocols and algorithmic tools are provided. Copyright © 2016 Elsevier Inc. All rights reserved.

Helium experiments on Alcator C-Mod in support of ITER early operations

DOE PAGES

Kessel, C. E.; Wolfe, S. M.; Reinke, M. L.; ...

2018-03-13

Helium majority experiments on Alcator C-Mod were performed to compare with deuterium discharges, and inform ITER early operations. ELMy H-modes were produced with a special plasma shape at B T = 5.3 T, I P = 0.9 MA, at q 95 ~ 3.8. The He fraction ranged over, n He,L/n L = 0.2–0.4, with n D,L/n L = 0.15–0.26, compared to D plasmas with n D,L/n L = 0.85–0.97. The power to enter the H-mode in He was found to be greater than ~2 times that for D discharges, in the low density region <1.4 × 10 20/m 3. However, it appears to follow the D threshold for higher densities. The stored energies in the He discharges were about 80% of those in D, and about 40% higher net power was required to sustain them compared to D. Global particle confinement times for tungsten ofmore » $$\\tau _{{\\rm W}}^{{\\rm *}}$$ /τ E ~ 4 were obtained with ELMy H-modes in He, however accumulation occurred when the ELMs were irregular and infrequent. The electron temperatures and densities in the pedestal were similar between D and He discharges, and the ΔT e/T e and Δn e/n e values were similar or larger in He than D. The higher net power required to access the H-mode, and sustain it in flattop, for He discharges in C-Mod, imply some limitations for He operation in ITER.« less

Helium experiments on Alcator C-Mod in support of ITER early operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kessel, C. E.; Wolfe, S. M.; Reinke, M. L.

Helium majority experiments on Alcator C-Mod were performed to compare with deuterium discharges, and inform ITER early operations. ELMy H-modes were produced with a special plasma shape at B T = 5.3 T, I P = 0.9 MA, at q 95 ~ 3.8. The He fraction ranged over, n He,L/n L = 0.2–0.4, with n D,L/n L = 0.15–0.26, compared to D plasmas with n D,L/n L = 0.85–0.97. The power to enter the H-mode in He was found to be greater than ~2 times that for D discharges, in the low density region <1.4 × 10 20/m 3. However, it appears to follow the D threshold for higher densities. The stored energies in the He discharges were about 80% of those in D, and about 40% higher net power was required to sustain them compared to D. Global particle confinement times for tungsten ofmore » $$\\tau _{{\\rm W}}^{{\\rm *}}$$ /τ E ~ 4 were obtained with ELMy H-modes in He, however accumulation occurred when the ELMs were irregular and infrequent. The electron temperatures and densities in the pedestal were similar between D and He discharges, and the ΔT e/T e and Δn e/n e values were similar or larger in He than D. The higher net power required to access the H-mode, and sustain it in flattop, for He discharges in C-Mod, imply some limitations for He operation in ITER.« less

Three Dimensional Hybrid Simulations of Super-Alfvénic Laser Ablation Experiments in the Large Plasma Device

NASA Astrophysics Data System (ADS)

Clark, Stephen; Winske, Dan; Schaeffer, Derek; Everson, Erik; Bondarenko, Anton; Constantin, Carmen; Niemann, Christoph

2014-10-01

We present 3D hybrid simulations of laser produced expanding debris clouds propagating though a magnetized ambient plasma in the context of magnetized collisionless shocks. New results from the 3D code are compared to previously obtained simulation results using a 2D hybrid code. The 3D code is an extension of a previously developed 2D code developed at Los Alamos National Laboratory. It has been parallelized and ported to execute on a cluster environment. The new simulations are used to verify scaling relationships, such as shock onset time and coupling parameter (Rm /ρd), developed via 2D simulations. Previous 2D results focus primarily on laboratory shock formation relevant to experiments being performed on the Large Plasma Device, where the shock propagates across the magnetic field. The new 3D simulations show wave structure and dynamics oblique to the magnetic field that introduce new physics to be considered in future experiments.

Mapping the Relevance of Complex Decision Making to Canadian Forces Land Operations (Mappage de la pertinence de la prise de d cisions complexes pour les op rations terrestres des Forces canadiennes)

DTIC Science & Technology

2011-03-01

operations erent types of lenge categor le pattern of of scenarios, ersonnel are nalysis s based upon . See Section t question th iffer on their...environmen change may Multiple con achievable a Underspecif Independent (they may h tential scen e complexity verall areas t ere both con ry operations rather...scenario de iption of the ghanistan operations co t as a liaison hanistan Nat of Security (N here was a m ut the level o in security. I security in

Draft genome sequence of Dethiobacter alkaliphilus strain AHT1T, a gram-positive sulfidogenic polyextremophile

DOE PAGES

Melton, Emily Denise; Sorokin, Dimitry Y.; Overmars, Lex; ...

2017-09-21

Dethiobacter alkaliphilus strain AHT1 T is an anaerobic, sulfidogenic, moderately salt-tolerant alkaliphilic chemolithotroph isolated from hypersaline soda lake sediments in northeastern Mongolia. It is thus a Gram-positive bacterium with low GC content, within the phylum Firmicutes. We report its draft genome sequence, which consists of 34 contigs with a total sequence length of 3.12 Mbp. D. alkaliphilus strain AHT1 T was sequenced by the Joint Genome Institute (JGI) as part of the Community Science Program due to its relevance to bioremediation and biotechnological applications.

Draft genome sequence of Dethiobacter alkaliphilus strain AHT1T, a gram-positive sulfidogenic polyextremophile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melton, Emily Denise; Sorokin, Dimitry Y.; Overmars, Lex

Dethiobacter alkaliphilus strain AHT1 T is an anaerobic, sulfidogenic, moderately salt-tolerant alkaliphilic chemolithotroph isolated from hypersaline soda lake sediments in northeastern Mongolia. It is thus a Gram-positive bacterium with low GC content, within the phylum Firmicutes. We report its draft genome sequence, which consists of 34 contigs with a total sequence length of 3.12 Mbp. D. alkaliphilus strain AHT1 T was sequenced by the Joint Genome Institute (JGI) as part of the Community Science Program due to its relevance to bioremediation and biotechnological applications.

B cells as accessory cells in a Con A response of a T cell clone.

PubMed

Takeuchi, M; Kakiuchi, T; Taira, S; Nariuchi, H

1987-12-01

Accessory cell (AC) function of B cells was examined in Con A response of a cloned T cell line, 22-9D, which is Thy 1+,L3T4+,Lyt2-,H-2KbDb+ and I-Ab-.22-9D cells produced IL 2 in the presence of Con A without participation of AC. For the initiation of a proliferative response to Con A, the addition of spleen cells or spleen adherent cells was required. B cells as AC were unable to induce the proliferative response. In the presence of culture supernatant of spleen cells stimulated with Con A (CAS), 22-9D cells showed proliferative response to Con A with B cell AC. The response was inhibited by a relevant monoclonal anti-I-A antibody. Although irradiated spleen cells as AC induced IL 2 receptor expression of 22-9D cells in the presence of Con A, B cells were shown to require the addition of unknown factor(s) in CAS, which was suggested to be different from IL 1, IL 2, IL 3, or IFN-gamma, for the induction of the receptor expression on 22-9D cells.

Conceptual Design of Tail-Research EXperiment (T-REX) on Space Plasma Environment Research Facility

NASA Astrophysics Data System (ADS)

Xiao, Qingmei; Wang, Xiaogang; E, Peng; Shen, Chao; Wang, Zhibin; Mao, Aohua; Xiao, Chijie; Ding, Weixing; Ji, Hantao; Ren, Yang

2016-10-01

Space Environment Simulation Research Infrastructure (SESRI), a scientific project for a major national facility of fundamental researches, has recently been launched at Harbin Institute of Technology (HIT). The Space Plasma Environment Research Facility (SPERF) for simulation of space plasma environment is one of the components of SESRI. It is designed to investigate fundamental issues in space plasma environment, such as energetic particles transportation and the interaction with waves in magnetosphere, magnetic reconnection at magnetopause and magnetotail, etc. Tail-Research Experiment (T-REX) is part of the SPERF for laboratory studies of space physics relevant to tail reconnection and dipolarization process. T-REX is designed to carry out two kinds of experiments: the tail plasmamoid for magnetic reconnection and magnetohydrodynamic waves excited by high speed plasma jet. In this presentation, the scientific goals and experimental plans for T-REX together with the means applied to generate the plasma with desired parameters are reviewed. Two typical scenarios of T-REX with operations of plasma sources and various magnetic configurations to study specific physical processes in space plasmas will also be presented.

J /ψ production at low transverse momentum in p +p and d + Au collisions at √{sN N}=200 GeV

NASA Astrophysics Data System (ADS)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chatterjee, A.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, S.; Gupta, A.; Guryn, W.; Hamad, A. I.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, X.; Huang, B.; Huang, H. Z.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jentsch, A.; Jia, J.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Koetke, D. D.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kumar, L.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, X.; Li, Y.; Li, W.; Lin, T.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, R.; Ma, G. L.; Ma, Y. G.; Ma, L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Matis, H. S.; McDonald, D.; McKinzie, S.; Meehan, K.; Mei, J. C.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Powell, C. B.; Pruthi, N. K.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, S.; Raniwala, R.; Ray, R. L.; Reed, R.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, A.; Sharma, B.; Sharma, M. K.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B.; Sun, Z.; Sun, X. M.; Sun, Y.; Surrow, B.; Svirida, D. N.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, F.; Wang, G.; Wang, J. S.; Wang, H.; Wang, Y.; Wang, Y.; Webb, G.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xin, K.; Xu, Y. F.; Xu, Q. H.; Xu, N.; Xu, H.; Xu, Z.; Xu, J.; Yang, S.; Yang, Y.; Yang, Y.; Yang, C.; Yang, Y.; Yang, Q.; Ye, Z.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, X. P.; Zhang, Y.; Zhang, J.; Zhang, J.; Zhang, S.; Zhang, S.; Zhang, Z.; Zhang, J. B.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.; STAR Collaboration

2016-06-01

We report on the measurement of J /ψ production in the dielectron channel at midrapidity (|y |<1 ) in p +p and d +Au collisions at √{sN N}=200 GeV from the STAR experiment at the Relativistic Heavy Ion Collider. The transverse momentum pT spectra in p +p for pT<4 GeV /c and d +Au collisions for pT<3 GeV /c are presented. These measurements extend the STAR coverage for J /ψ production in p +p collisions to low pT. The from the measured J /ψ invariant cross section in p +p and d +Au collisions are evaluated and compared to similar measurements at other collision energies. The nuclear modification factor for J /ψ is extracted as a function of pT and collision centrality in d +Au and compared to model calculations using the modified nuclear parton distribution function and a final-state J /ψ nuclear absorption cross section.

J / ψ production at low transverse momentum in p + p and d + Au collisions at s N N = 200 GeV

DOE PAGES

Adamczyk, L.

2016-06-10

Inmore » this paper, we report on the measurement of J/ψ production in the dielectron channel at midrapidity (|y| < 1) in p + p and d + Au collisions at s N N = 200 from the STAR experiment at the Relativistic Heavy Ion Collider. The transverse momentum p T spectra in p + p for p T < 4 GeV/c and d + Au collisions for p T < 3 GeV/c are presented. These measurements extend the STAR coverage for J/ψ production in p + p collisions to low p T . The < p$$2\\atop{T}$$ > from the measured J/ψ invariant cross section in p + p and d + Au collisions are evaluated and compared to similar measurements at other collision energies. The nuclear modification factor for J/ψ is extracted as a function of p T and collision centrality in d + Au and compared to model calculations using the modified nuclear parton distribution function and a final-state J/ψ nuclear absorption cross section.« less

Electrical brain stimulation (tES) improves learning more than performance: A meta-analysis.

PubMed

Simonsmeier, Bianca A; Grabner, Roland H; Hein, Julia; Krenz, Ugne; Schneider, Michael

2018-01-01

Researchers have recently started evaluating whether stimulating the brain noninvasively with a weak and painless electrical current (transcranial Electrical Stimulation, tES) enhances physiological and cognitive processes. Some studies found that tES has weak but positive effects on brain physiology, cognition, or assessment performance, which has attracted massive public interest. We present the first meta-analytic test of the hypothesis that tES in a learning phase is more effective than tES in an assessment phase. The meta-analysis included 246 effect sizes from studies on language or mathematical competence. The effect of tES was stronger when stimulation was administered during a learning phase (d=0.712) as compared to stimulation administered during test performance (d=0.207). The overall effect was stimulation-dosage specific and, as found in a previous meta-analysis, significant only for anodal stimulation and not for cathodal. The results provide evidence for the modulation of long-term synaptic plasticity by tES in the context of practically relevant learning tasks and highlight the need for more systematic evaluations of tES in educational settings. Copyright © 2017 Elsevier Ltd. All rights reserved.

Use of a 3-Telsa magnet to perform delayed gadolinium-enhanced magnetic resonance imaging of the distal interphalangeal joint of horses with and without naturally occurring osteoarthritis.

PubMed

Bischofberger, Andrea S; Fürst, Anton E; Torgerson, Paul R; Carstens, Ann; Hilbe, Monika; Kircher, Patrick

2018-03-01

OBJECTIVE To characterize delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) features of healthy hyaline cartilage of the distal interphalangeal joint (DIPJ) of horses, to determine whether dGEMRIC can be used to differentiate various stages of naturally occurring osteoarthritis of the DIPJ, and to correlate relaxation times determined by dGEMRIC with the glycosaminoglycan concentration, water content, and macroscopic and histologic findings of hyaline cartilage of DIPJs with and without osteoarthritis. SAMPLE 1 cadaveric forelimb DIPJ from each of 12 adult warmblood horses. PROCEDURES T1-weighted cartilage relaxation times were obtained for predetermined sites of the DIPJ before (T1 preGd ) and after (T1 postGd ) intra-articular gadolinium administration. Corresponding cartilage sites underwent macroscopic, histologic, and immunohistochemical evaluation, and cartilage glycosaminoglycan concentration and water content were determined. Median T1 preGd and T1 postGd were correlated with macroscopic, histologic, and biochemical data. Mixed generalized linear models were created to evaluate the effects of cartilage site, articular surface, and macroscopic and histologic scores on relaxation times. RESULTS 122 cartilage specimens were analyzed. Median T1 postGd was lower than the median T1 preGd for normal and diseased cartilage. Both T1 preGd and T1 postGd were correlated with macroscopic and histologic scores, whereby T1 preGd increased and T1 postGd decreased as osteoarthritis progressed. There was topographic variation of T1 preGd and T1 postGd within the DIPJ. Cartilage glycosaminoglycan concentration and water content were significantly correlated with T1 preGd and macroscopic and histologic scores but were not correlated with T1 postGd . CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that dGEMRIC relaxation times varied for DIPJs with various degrees of osteoarthritis. These findings may help facilitate early detection of osteoarthritis.

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies.

PubMed

Roshanzamir, F; Miraghajani, M; Rouhani, M H; Mansourian, M; Ghiasvand, R; Safavi, S M

2018-01-01

Fetuin-A is a liver-derived circulating protein that is associated with insulin resistance and diabetes. The objective of this systematic review and meta-analysis of published observational studies was to investigate mean levels of fetuin-A in T2D patients and the relationship between blood fetuin-A levels and T2D risk. PubMed, Embase, Google Scholar, Web of Science, and The Cochrane Library were systematically searched for potential relevant studies up to 1 December 2016. Natural logarithm-transformed estimate risks, standard mean differences on the basis of Hedges's adjusted g, and 95% confidence intervals (CIs) were calculated for all eligible studies and were combined to measure the pooled data using random-effects model. A total of 32 studies including 27 case-control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges' g = 1.73, 95% CI (1.25-2.22), P < 0.001], with significant heterogeneity across studies (P < 0.001, I 2  = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26-2.08), P < 0.001], with no significant heterogeneity (P = 0.10, I 2  = 46.06%). We found a significant relationship between the fetuin-A levels with T2D risk. Although fetuin-A may be as a potential screening and prediction biomarker or a therapeutic target in T2D patients, further studies are required in this regard.

Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data.

PubMed

Beyerlein, Andreas; Strobl, Andreas N; Winkler, Christiane; Carpus, Michaela; Knopff, Annette; Donnachie, Ewan; Ankerst, Donna P; Ziegler, Anette-G

2017-03-27

Vaccinations in early childhood potentially stimulate the immune system and may thus be relevant for the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). We determined the association of vaccination burden with T1D-associated islet autoimmunity in children with high familial risk followed prospectively from birth. A total of 20,570 certified vaccination records from 1918 children were correlated with time to onset of T1D-associated islet autoimmunity using Cox regression, considering multiple time periods up until age two years and vaccination types, and adjusting for HLA genotype, sex, delivery mode, season of birth, preterm delivery and maternal T1D status. Additionally, prospective claims data of 295,420 subjects were used to validate associations for the tick-borne encephalitis (TBE) vaccination. Most vaccinations were not associated with a significantly increased hazard ratio (HR) for islet autoimmunity (e.g. HR [95% confidence interval]: 1.08 [0.96-1.21] per additional vaccination against measles, mumps and rubella at age 0-24months). TBE vaccinations within the first two years of life were nominally associated with a significantly increased autoimmunity risk (HR: 1.44 [1.06-1.96] per additional vaccination at age 0-24months), but this could not be confirmed with respect to outcome T1D in the validation cohort (HR: 1.02 [0.90-1.16]). We found no evidence that early vaccinations increase the risk of T1D-associated islet autoimmunity development. The potential association with early TBE vaccinations could not be confirmed in an independent cohort and appears to be a false positive finding. Copyright © 2017 Elsevier Ltd. All rights reserved.

Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States.

PubMed

DuBose, Stephanie N; Hermann, Julia M; Tamborlane, William V; Beck, Roy W; Dost, Axel; DiMeglio, Linda A; Schwab, Karl Otfried; Holl, Reinhard W; Hofer, Sabine E; Maahs, David M

2015-09-01

To examine the current extent of the obesity problem in 2 large pediatric clinical registries in the US and Europe and to examine the hypotheses that increased body mass index (BMI) z-scores (BMIz) are associated with greater hemoglobin A1c (HbA1c) and increased frequency of severe hypoglycemia in youth with type 1 diabetes (T1D). International (World Health Organization) and national (Centers for Disease Control and Prevention/German Health Interview and Examination Survey for Children and Adolescents) BMI references were used to calculate BMIz in participants (age 2-<18 years and ≥ 1 year duration of T1D) enrolled in the T1D Exchange (n = 11,435) and the Diabetes Prospective Follow-up (n = 21,501). Associations between BMIz and HbA1c and severe hypoglycemia were assessed. Participants in both registries had median BMI values that were greater than international and their respective national reference values. BMIz was significantly greater in the T1D Exchange vs the Diabetes Prospective Follow-up (P < .001). After stratification by age-group, no differences in BMI between registries existed for children 2-5 years, but differences were confirmed for 6- to 9-, 10- to 13-, and 14- to 17-year age groups (all P < .001). Greater BMIz were significantly related to greater HbA1c levels and more frequent occurrence of severe hypoglycemia across the registries, although these associations may not be clinically relevant. Excessive weight is a common problem in children with T1D in Germany and Austria and, especially, in the US. Our data suggest that obesity contributes to the challenges in achieving optimal glycemic control in children and adolescents with T1D. Copyright © 2015 Elsevier Inc. All rights reserved.

D-galactose induces necroptotic cell death in neuroblastoma cell lines.

PubMed

Li, Na; He, Yangyan; Wang, Ling; Mo, Chunfen; Zhang, Jie; Zhang, Wei; Li, Junhong; Liao, Zhiyong; Tang, Xiaoqiang; Xiao, Hengyi

2011-12-01

D-Galactose (D-gal) can induce oxidative stress in non-cancer cells and result in cell damage by disturbing glucose metabolism. However, the effect of D-gal on cancer cells is yet to be explored. In this study, we investigated the toxicity of D-gal to malignant cells specifically neuroblastoma cells. As the results, high concentrations of D-gal had significant toxicity to cancer cells, whereas the same concentrations of glucose had no; the viability loss via D-gal treatment was prominent to malignant cells (Neuro2a, SH-SY5Y, PC-3, and HepG2) comparing to non-malignant cells (NIH3T3 and LO(2)). Differing from the apoptosis induced by H(2) O(2), D-gal damaged cells showed the characters of necrotic cell death, such as trypan blue-tangible and early phase LDH leakage. Further experiments displayed that the toxic effect of D-gal can be alleviated by necroptosis inhibitor Necrostatin (Nec-1) and autophagy inhibitor 3-methyladenine (3-MA) but not by caspase inhibitor z-VAD-fmk. D-Gal treatment can transcriptionally up-regulate the genes relevant to necroptosis (Bmf, Bnip3) and autophagy (Atg5, TIGAR) but not the genes related to apoptosis (Caspase3, Bax, and p53). D-Gal did not activate Caspase-3, but prompted puncta-like GFP-LC3 distribution, an indicator for activated autophagy. The involvement of aldose reductase (AR)-mediated polyol pathway was proved because the inhibitor of AR can attenuate the toxicity of D-gal and D-gal treatment elevates the expression of AR. This study demonstrates for the first time that D-gal can induce non-apoptotic but necroptotic cell death in neuroblastoma cells and provides a new clue for developing the strategy against apoptosis-resistant cancers. Copyright © 2011 Wiley Periodicals, Inc.

Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence.

PubMed

Vaiserman, Alexander M

2017-03-05

Consistent evidence from both experimental and human studies suggest that inadequate nutrition in early life can contribute to risk of developing metabolic disorders including type 2 diabetes (T2D) in adult life. In human populations, most findings supporting a causative relationship between early-life malnutrition and subsequent risk of T2D were obtained from quasi-experimental studies ('natural experiments'). Prenatal and/or early postnatal exposures to famine were demonstrated to be associated with higher risk of T2D in many cohorts around the world. Recent studies have highlighted the importance of epigenetic regulation of gene expression as a possible major contributor to the link between the early-life famine exposure and T2D in adulthood. Findings from these studies suggest that prenatal exposure to the famine may result in induction of persistent epigenetic changes that have adaptive significance in postnatal development but can predispose to metabolic disorders including T2D at the late stages of life. In this review, quasi-experimental data on the developmental programming of T2D are summarized and recent research findings on changes in DNA methylation that mediate these effects are discussed.

Summary Review of the Aquatic Toxicology of Munitions Constituents

DTIC Science & Technology

2013-06-01

to be related to explosives-induced changes in the nutritional status of the sediment and biochemical and physiological alterations in invertebrates...vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry. J. Inorg. Biochem., 68:273-278. Belden...Maryland System, Agricultural Experiment Station, Wye Research and Education Center. Burton, D. T., S. D. Turley, G. T. Peters. 1994. The acute and

First measurement of T -odd moments in D 0 → K S 0 π + π - π 0 decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prasanth, K.; Libby, J.; Adachi, I.

2017-05-01

We report the first measurement of the T-odd moments in the decay D 0 → Kmore » $$0\\atop{S}$$π +π -π 0 from a data sample corresponding to an integrated luminosity of 966 fb -1 collected by the Belle experiment at the KEKB asymmetric-energy eþe- collider.« less

Experimental results of temperature response to stress change: An indication of the physics of earthquake rupture propagation

NASA Astrophysics Data System (ADS)

Lin, W.; Yang, X.; Tadai, O.; Zeng, X.; Yeh, E. C.; Yu, C.; Hatakeda, K.; Xu, H.; Xu, Z.

2016-12-01

As a result of the earthquake rupture propagation, stress on the earthquake fault and in the hanging wall and in the footwall coseismically drops. Based on the thermo-elasticity theory, the temperature of rocks may change associated with coseismic stress change at the same time as their elastic deformation. This coseismic temperature change is one of the physics of earthquake rupture propagation, however has not been noted and expressly addressed before. To understand this temperature issue, we conducted laboratory experiments to quantitatively investigate temperatures response of rocks to rapid stress change of various typical rocks. Consequently, we developed a hydrostatic compression experimental equipment for rock samples with a high resolution temperature measuring system. This enable us to rapidly load and/or unload the confining pressure. As experimental rock samples, we collected 15 representative rocks from various scientific drilling projects and outcrops of earthquake faults, and quarries in the world. The rock types include sandstone, siltstone, limestone, granite, basalt, tuff etc. Based on the classical thermo-elastic theory, a conventional relationship between the temperature change (dT) of rock samples and the confining pressure change (dP) in the hydrostatic compression system under adiabatic condition can be expressed as a linear function. Therefore, we can measure the adiabatic pressure derivative of temperature (dT/dP) directly by monitoring changes of rock sample temperature and confining pressure during the rapidly loading and unloading processes. As preliminary results of the experiments, the data of 15 rock samples showed that i) the adiabatic pressure derivative of temperature (dT/dP) of most rocks are about 1.5 6.2 mK/MPa; ii) the dT/dP of sedimentary rocks is larger than igneous and metamorphic rocks; iii) a good linear correlation between dT/dP and the rock's bulk modulus was recognized.

The dtd gene from Bacillus amyloliquefaciens encodes a putative D-tyrosyl-tRNATyr deacylase and is a selectable marker for Bacillus subtilis.

PubMed

Geraskina, Natalia V; Butov, Ivan A; Yomantas, Yurgis A V; Stoynova, Nataliya V

2015-02-01

Genetically engineered microbes are of high practical importance due to their cost-effective production of valuable metabolites and enzymes, and the search for new selectable markers for genetic manipulation is of particular interest. Here, we revealed that the soil bacterium Bacillus amyloliquefaciens A50 is tolerant to the non-canonical amino acid D-tyrosine (D-Tyr), in contrast to the closely related Bacillus strain B. subtilis 168, which is a widely used "domesticated" laboratory strain. The gene responsible for resistance to D-Tyr was identified. The resistance was associated with the activity of a potential D-tyrosyl-tRNA(Tyr) deacylase. Orthologs of this enzyme are capable of hydrolyzing the ester bond and recycling misacetylated D-aminoacyl-tRNA molecules into free tRNAs and D-amino acids. This gene, yrvI (dtd), is applicable as a convenient, small selectable marker for non-antibiotic resistance selection in experiments aimed at genome editing of D-Tyr-sensitive microorganisms. Copyright © 2014 Elsevier GmbH. All rights reserved.

Reconnection Scaling Experiment (RSX): Magnetic Reconnection in Linear Geometry

NASA Astrophysics Data System (ADS)

Intrator, T.; Sovinec, C.; Begay, D.; Wurden, G.; Furno, I.; Werley, C.; Fisher, M.; Vermare, L.; Fienup, W.

2001-10-01

The linear Reconnection Scaling Experiment (RSX) at LANL is a new experiment that can create MHD relevant plasmas to look at the physics of magnetic reconnection. This experiment can scale many relevant parameters because the guns that generate the plasma and current channels do not depend on equilibrium or force balance for startup. We describe the experiment and initial electrostatic and magnetic probe data. Two parallel current channels sweep down a long plasma column and probe data accumulated over many shots gives 3D movies of magnetic reconnection. Our first data tries to define an operating regime free from kink instabilities that might otherwise confuse the data and shot repeatability. We compare this with MHD 2 fluid NIMROD simulations of the single current channel kink stability boundary for a variety of experimental conditions.

Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil

PubMed Central

Estensoro, Itziar; Ballester-Lozano, Gabriel; Benedito-Palos, Laura; Grammes, Fabian; Martos-Sitcha, Juan Antonio; Mydland, Liv-Torunn; Calduch-Giner, Josep Alvar; Fuentes, Juan; Karalazos, Vasileios; Ortiz, Álvaro; Øverland, Margareth; Pérez-Sánchez, Jaume

2016-01-01

There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period. In a second longer trial (T2) (8 months), four diets were used: a control diet containing 25% FM (T2-D1) and three experimental diets containing 5% FM (T2-D2, T2-D3, T2-D4). FO was the only added oil in D1, while a blend of plant oils replaced 58% and 84% of FO in T2-D2, and T2-D3 and T2-D4, respectively. The latter was supplemented with 0.4% BP-70. In a third trial (T3), two groups of fish were fed for 12 and 38 months with D1, D3 and D4 diets of T2. The effects of dietary changes were studied using histochemical, immunohistochemical, molecular and electrophysiological tools. The extreme diet (T2-D3) modified significantly the transcriptomic profile, especially at the anterior intestine, up-regulating the expression of inflammatory markers, in coincidence with a higher presence of granulocytes and lymphocytes in the submucosa, and changing genes involved in antioxidant defences, epithelial permeability and mucus production. Trans-epithelial electrical resistance (Rt) was also decreased (T3-D3). Most of these modifications were returned to control values with the addition of BP-70. None of the experimental diets modified the staining pattern of PCNA, FABP2 or ALPI. These results further confirm the potential of this additive to improve or reverse the detrimental effects of extreme fish diet formulations. PMID:27898676

Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil.

PubMed

Estensoro, Itziar; Ballester-Lozano, Gabriel; Benedito-Palos, Laura; Grammes, Fabian; Martos-Sitcha, Juan Antonio; Mydland, Liv-Torunn; Calduch-Giner, Josep Alvar; Fuentes, Juan; Karalazos, Vasileios; Ortiz, Álvaro; Øverland, Margareth; Sitjà-Bobadilla, Ariadna; Pérez-Sánchez, Jaume

2016-01-01

There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period. In a second longer trial (T2) (8 months), four diets were used: a control diet containing 25% FM (T2-D1) and three experimental diets containing 5% FM (T2-D2, T2-D3, T2-D4). FO was the only added oil in D1, while a blend of plant oils replaced 58% and 84% of FO in T2-D2, and T2-D3 and T2-D4, respectively. The latter was supplemented with 0.4% BP-70. In a third trial (T3), two groups of fish were fed for 12 and 38 months with D1, D3 and D4 diets of T2. The effects of dietary changes were studied using histochemical, immunohistochemical, molecular and electrophysiological tools. The extreme diet (T2-D3) modified significantly the transcriptomic profile, especially at the anterior intestine, up-regulating the expression of inflammatory markers, in coincidence with a higher presence of granulocytes and lymphocytes in the submucosa, and changing genes involved in antioxidant defences, epithelial permeability and mucus production. Trans-epithelial electrical resistance (Rt) was also decreased (T3-D3). Most of these modifications were returned to control values with the addition of BP-70. None of the experimental diets modified the staining pattern of PCNA, FABP2 or ALPI. These results further confirm the potential of this additive to improve or reverse the detrimental effects of extreme fish diet formulations.

Tridimensional Thermonuclear Instability in Subignited Plasmas and on the Surface of the Pulsars

NASA Astrophysics Data System (ADS)

Cardinali, A.; Coppi, B.

2017-10-01

Tridimensional modes involving an increase of the electron temperature can be excited as a result of alpha-particle heating in subignited D-T fusion burning plasmas when a nearly time- independent external source of heating is applied. The analyzed modes are shown to emerge from an axisymmetric toroidal configurations and are radially localized around rational magnetic surfaces corresponding to q(r =r0) =m0 /n0 where m0 and n0 are the relevant poloidal and toroidal mode numbers. The radial width of the mode is of the order of the thermal scale distance. The mode has a rather severe damping rate, that has to be overcome by the relevant heating rate. Thus the temperature range to be considered is that where the D-T plasma reactivity undergoes a relatively large increase as a function of temperature. This kind of theory has been applied to the plasmas that are envisioned to be associated with surface of pulsar and be subjects to (spatially) inhomogenous thermonuclear burning. Sponsored in part by the U.S. DoE.

The non-modulated transfer of total effluent for serially coupled columns in gas chromatography.

PubMed

Krupcík, Ján; Mydlová-Memersheimerová, Janka; Májek, Pavel; Zapadlo, Michal; Sandra, Pat

2010-03-12

The non-modulated transfer (NMT) of the total effluent of the separation of polychlorinated biphenyls (PCBs) on two columns coupled in series has been studied. A non-polar poly(5%-phenyl-95%-methyl)siloxane column (40 m x 100 microm x 0.1 microm) and a polar 70%-cyanopropyl-polysilphenylene-siloxane column (4 m x 0.1 mm x 0.1 microm) were used as (1)D and (2)D columns, respectively. The effluents from both the (1)D column and the (1)D+(2)D column series were monitored independently by two FIDs. Data from the (1)D and (1)D+(2)D integration reports were used to evaluate the NMT experiment. (1)D retention times, t(R,i,D1), were directly accessible from (1)D integration report while (2)D retention times, t(R,i,B), were calculated for all corresponding peak pairs from (1)D and (1)D+(2)D integration reports as a difference t(R,i,D2)=t(R,i,D1+D2)-t(R,i,D1). Search for corresponding peaks of PCB congeners in the (1)D and (1)D+(2)D chromatograms is elucidated in detail on standard PCB samples and on PCB congeners present in the technical formulation Arochlor 1242. Both retention times (t(R,i,D1) and t(R,i,D2)) as well as peak widths at half height (w(h,i)) and peak heights (h(i)) obtained from integration reports were used to construct 2D and 3D images for PCB NMT separations on serially coupled columns. The performance of the NMT procedure is illustrated by the separation of (i) standard PCB solutions, (ii) a mixture of the 209 PCBs, and (iii) a mixture of Arochlor 1242 and hydrocarbons on the DB-5+BPX-70 column series. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Study of Perturbations on High Mach Number Blast Waves in Various Gasses

NASA Astrophysics Data System (ADS)

Edens, A.; Adams, R.; Rambo, P.; Shores, J.; Smith, I.; Atherton, B.; Ditmire, T.

2006-10-01

We have performed a series of experiments examining the properties of high Mach number blast waves. Experiments were conducted on the Z-Beamlet^1 laser at Sandia National Laboratories. We created blast waves in the laboratory by using 10 J- 1000 J laser pulses to illuminate millimeter scale solid targets immersed in gas. Our experiments studied the validity of theories forwarded by Vishniac and Ryu^2-4 to explain the dynamics of perturbations on astrophysical blast waves. These experiments consisted of an examination of the evolution of perturbations of known primary mode number induced on the surface of blast waves by means of regularly spaced wire arrays. The temporal evolution of the amplitude of the induced perturbations relative to the mean radius of the blast wave was fit to a power law in time. Measurements were taken for a number of different mode numbers and background gasses and the results show qualitative agreement with previously published theories for the hydrodynamics of thin shell blast wave. The results for perturbations on nitrogen gas have been recently published^5. .^1 P. K. Rambo, I. C. Smith, J. L. Porter, et al., Applied Optics 44, 2421 (2005). ^2 D. Ryu and E. T. Vishniac, Astrophysical Journal 313, 820 (1987). ^3 D. Ryu and E. T. Vishniac, Astrophysical Journal 368, 411 (1991). ^4 E. T. Vishniac, Astrophysical Journal 274, 152 (1983). ^5 A. D. Edens, T. Ditmire, J. F. Hansen, et al., Physical Review Letters 95 (2005).

Metal/Silicate Partitioning of W, Ge, Ga and Ni: Dependence on Silicate Melt Composition

NASA Astrophysics Data System (ADS)

Singletary, S.; Drake, M. J.

2004-12-01

Metal/silicate partition coefficients (Dm/s) for siderophile elements are essential to investigations of core formation when used in conjunction with the pattern of elemental abundances in the Earth's mantle (Drake and Righter, 2002; Jones and Drake, 1986; Righter et al. 1997). The partitioning of siderophile elements is controlled by temperature, pressure, oxygen fugacity, and by the compositions of the metal and silicate phases. In this work, we investigate the role of silicate melt composition on the partitioning of the siderophile elements W, Ge, Ga and Ni between metallic and silicate liquid. Experiments were performed in the Experimental Geochemistry Laboratory at the University of Arizona utilizing a non-end loaded piston cylinder apparatus with a barium carbonate pressure medium. Starting materials were created by combining the mafic and silicic compositions of Jaeger and Drake (2000) with Fe powder (~25 wt% of the total mixture) to achieve metal saturation. Small amounts of W, Ge, Ga2O3 and NiO powder (less than 2 wt% each) were also added to the starting compositions. The experiments were contained in a graphite capsule and performed with temperature and pressure fixed at 1400ºC and 1.5 GPa. Experimental run products were analyzed with the University of Arizona Cameca SX50 electron microprobe with four wavelength dispersive spectrometers and a PAP ZAF correction program. All experiments in our set are saturated with metal and silicate liquid, indicating that oxygen fugacity is below IW. Several of the runs also contain a gallium-rich spinel as an additional saturating phase. Quench phases are also present in the silicate liquid in all runs. The experimentally produced liquids have nbo/t values (calculated using the method of Mills, 1993) that range from 1.10 to 2.97. These values are higher than those calculated for the liquids in the Jaeger and Drake (2000) study. The higher nbo/t values are due to uptake of Fe by the melt. The initial silicate composition contained no FeO, however the experimentally produced silicate liquids contained from 15 to 26 wt % FeO. We find that W is incompatible over the range of compositions used in this study. However, W compatibility increases as melts become more silicic, with D(W) = 0.0005 at nbo/t = 2.97 and D(W) = 0.09 at nbo/t = 1.1. The slope of the best fit line for the W data when plotted in nbo/t vs Log D space is -1.22 and close to the value of -1.34 found by Jaeger and Drake (2000). Ge is compatible at all compositions and follows a similar pattern to that of W becoming more compatible with decreasing nbo/t (D(Ge)= 14 at nbo/t = 2.97 and D(Ge) = 100 at nbo/t = 1.1). Ni and Ga display essentially flat slopes within the error of our analysis, with D(Ni) = 395 at nbo/t = 2.97 and D(Ni) = 870 at nbo/t 1.10 and D(Ga) = 0.08 at nbo/t = 2.97 and D(Ga) = 0.02 at nbo/t = 1.1. A second series of experiments is in progress to verify these data and extend the study to lower values of nbo/t. References: Drake, M.J. and Righter, K. (2002) Nature, v. 416, 39-44; Jones, J.H. and Drake, M.J. (1986) Nature, v. 323, 470-471; Righter, K., et al. (1997) Physics Earth and Planet. Int., v. 100, 115-134; Jaeger, W.L. and Drake, M.J. (2000) Geo. Cosmo. Acta, v. 64, 3887-3895; Mills, K.C. (1993) ISIJ International, v. 33, 148-155.

Retrieved Products from Simulated Hyperspectral Observations of a Hurricane

NASA Technical Reports Server (NTRS)

Susskind, Joel; Kouvaris, Louis; Iredell, Lena; Blaisdell, John

2015-01-01

Retrievals were run using the AIRS Science Team Version-6 AIRS Only retrieval algorithm, which generates a Neural-Net first guess (T(sub s))(sup 0), (T(p))(sup 0), and (q(p))(sup 0) as a function of observed AIRS radiances. AIRS Science Team Neural-Net coefficients performed very well beneath 300 mb using the simulated radiances. This means the simulated radiances are very realistic. First guess and retrieved values of T(p) above 300 mb were biased cold, but both represented the model spatial structure very well. QC'd T(p) and q(p) retrievals for all experiments had similar accuracies compared to their own truth fields, and were roughly consistent with results obtained using real data. Spatial coverage of retrievals, as well as the representativeness of the spatial structure of the storm, improved dramatically with decreasing size of the instrument's FOV. We sent QC'd values of T(p) and q(p) to Bob Atlas at AOML for use as input to OSSE Data Assimilation experiments.

Magnetic field effects of photocarrier generation in bulk heterojunctions at low temperature.

PubMed

Tajima, H; Nishioka, Y; Sato, S; Suzuki, T; Kimata, M

2016-11-14

We report an experimental investigation of the magnetic field effect (MFE) in polymer bulk heterojunction devices at temperatures below 10 K using photocarrier extraction by linearly increasing voltages. The examined devices were composed of an active layer of poly(3-hexylthiophene) and [6,6]-phenyl-C 61 -butyric acid methyl ester. In the experiments, the delay time (t d ) dependence of the MFE was investigated in detail. For t d < 80 μs, a positive MFE was observed in the field region B < 0.1 T and a negative MFE was observed for B > 0.2 T. For t d > 8 ms, only a positive MFE proportional to B 2 was observed. For the photocurrent pulse detected immediately after light irradiation, the MFE was negligibly small. In a high magnetic field of 15 T, a significant MFE exceeding 80% was observed at 1.8 K for t d = 800 ms. We discuss the results based on a model of triplet-singlet (or singlet-triplet) conversion in the magnetic field and estimate the exchange integral for the charge-transfer exciton in this photovoltaic cell.

Effects of Cocoa Antioxidants in Type 2 Diabetes Mellitus.

PubMed

Ramos, Sonia; Martín, María Angeles; Goya, Luis

2017-10-31

Type 2 Diabetes mellitus (T2D) is the most common form of diabetes and one of the most common chronic diseases. Control of hyperglycaemia by hypoglycaemic drugs is insufficient in for patients and nutritional approaches are currently being explored. Natural dietary compounds such as flavonoids, abundant in fruits and vegetables, have received broad attention because of their potential capacity to act as anti-diabetic agents. Especially cocoa flavonoids have been proved to ameliorate important hallmarks of T2D. In this review, an update of the most relevant reports published during the last decade in cell culture, animal models and human studies is presented. Most results support an anti-diabetic effect of cocoa flavonoids by enhancing insulin secretion, improving insulin sensitivity in peripheral tissues, exerting a lipid-lowering effect and preventing the oxidative and inflammatory damages associated to the disease. While it could be suggested that daily consumption of flavanols from cocoa or dark chocolate would constitute a potential preventive tool useful for the nutritional management of T2D, this recommendation should be cautious since most of commercially available soluble cocoa products or chocolates contain low amount of flavanols and are rich in sugar and calories that may aggravate glycaemic control in T2D patients.

Effects of Cocoa Antioxidants in Type 2 Diabetes Mellitus

PubMed Central

Martín, María Angeles; Goya, Luis

2017-01-01

Type 2 Diabetes mellitus (T2D) is the most common form of diabetes and one of the most common chronic diseases. Control of hyperglycaemia by hypoglycaemic drugs is insufficient in for patients and nutritional approaches are currently being explored. Natural dietary compounds such as flavonoids, abundant in fruits and vegetables, have received broad attention because of their potential capacity to act as anti-diabetic agents. Especially cocoa flavonoids have been proved to ameliorate important hallmarks of T2D. In this review, an update of the most relevant reports published during the last decade in cell culture, animal models and human studies is presented. Most results support an anti-diabetic effect of cocoa flavonoids by enhancing insulin secretion, improving insulin sensitivity in peripheral tissues, exerting a lipid-lowering effect and preventing the oxidative and inflammatory damages associated to the disease. While it could be suggested that daily consumption of flavanols from cocoa or dark chocolate would constitute a potential preventive tool useful for the nutritional management of T2D, this recommendation should be cautious since most of commercially available soluble cocoa products or chocolates contain low amount of flavanols and are rich in sugar and calories that may aggravate glycaemic control in T2D patients. PMID:29088075

Transport and Magnetization in Bad Metals Itinerant Ferromagnets

NASA Astrophysics Data System (ADS)

Klein, Lior

1997-03-01

While much attention has been given to the study of itinerant ferromagnets that are good metals (k_Fl >> 1), very little is known about the transport properties of itinerant ferromagnets in the badly metallic limit (k_Fl= \\cal O ). Here we present our study of the pseudo-cubic perovskite SrRuO3 which is in the limit of k_Fl= \\cal O (1) in its purest form (e.g. single crystals) and is also an itinerant ferromagnet with Tc ~ 160 K. We findfootnote L. Klein, J. S. Dodge, C. H. Ahn, G. J. Snyder, T. H. Geballe, M. R. Beasley, and A. Kapitulnik, Phys. Rev. Lett. 77, 2774 (1996); L. Klein, J. S. Dodge, C. H. Ahn, J. W. Reiner, L. Mieville, T. H.Geballe, M. R. Beasley, and A. Kapitulnik, J. Phys. Condens. Matter 8, 10111 (1996). that while the magnetic properties of SrRuO3 in the paramagnetic phase, near the ferromagnetic phase transition and at low temperatures are normal and similar to those of iron or nickel, the transport properties sharply deviate from those of good metallic ferromagnets: a) As Tarrow T_c^+ the temperature derivative of the magnetic part of the resistivity, dρ _m/dT, diverges with an exponent on the order of 1, an order of magnitude larger than the expected specific heat exponent of ~ 0.1. b) While the critical behavior of dρ _m/dT around Tc is usually found to be symmetric, very weak divergence of dρ _m/dT is observed as Tarrow T_c^-. c) At low temperatures ρ rapidly increases in correlation with the magnetization instead of the usually observed T^2 dependence. d) At T < 4 K for low-residual-resistivity films, and at higher temperatures for high-residual-resistivity films, Kondo-like resistivity minima are observed. We conjecture that the distinct transport behavior of SrRuO3 is related to its being a 'bad metal' in the k_Fl= \\cal O (1) limit, and discuss the possible relevance of our results to the unusual transport properties of other 'bad metals' such as high-temperature superconductors, fullerenes and organic conductors.

Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells

PubMed Central

Steigerwald, Jutta; Raum, Tobias; Pflanz, Stefan; Cierpka, Ronny; Mangold, Susanne; Rau, Doris; Hoffmann, Patrick; Kvesic, Majk; Zube, Christina; Linnerbauer, Stefanie; Lumsden, John; Sriskandarajah, Mirnaalini; Kufer, Peter; Baeuerle, Patrick A

2009-01-01

NKG2D is a surface receptor expressed on NK cells but also on CD8+ T cells, γδ T cells, and auto-reactive CD4+/CD28− T cells of patients with rheumatoid arthritis. Various studies suggested that NKG2D plays a critical role in autoimmune diseases, e.g., in diabetes, celiac disease and rheumatoid arthritis (RA), rendering the activating receptor a potential target for antibody-based therapies. Here, we describe the generation and characteristics of a panel of human, high-affinity anti-NKG2D IgG1 monoclonal antibodies (mAbs) derived by phage display. The lead molecule mAb E4 bound with an affinity (KD) of 2.7 ± 1.4 × 10−11 M to soluble and membrane-bound human NKG2D, and cross-reacted with NKG2D from cynomolgus macaque, indicating potential suitability for studies in a relevant primate model. MAb E4 potently antagonized the cytolytic activity of NKL cells against BaF/3-MICA cells expressing NKG2D ligand, and blocked the NKG2D ligand-induced secretion of TNFα, IFNγ and GM-CSF, as well as surface expression of CRTAM by NK cells cultured on immobilized MICA or ULBP-1 ligands. The antibody did not show a detectable loss of binding to NKG2D after seven days in human serum at 37°C, and resisted thermal inactivation up to 70°C. Based on these results, anti-human NKG2D mAb E4 provides an ideal candidate for development of a novel therapeutic agent antagonizing a key receptor of NK and cytotoxic T cells with implications in autoimmune diseases. PMID:20061825

Augmented Reality Robot-assisted Radical Prostatectomy: Preliminary Experience.

PubMed

Porpiglia, Francesco; Fiori, Cristian; Checcucci, Enrico; Amparore, Daniele; Bertolo, Riccardo

2018-05-01

To present our preliminary experience with augmented reality robot-assisted radical prostatectomy (AR-RARP). From June to August 2017, patients candidate to RARP were enrolled and underwent high-resolution multi-parametric magnetic resonance imaging (1-mm slices) according to dedicated protocol. The obtained three-dimensional (3D) reconstruction was integrated in the robotic console to perform AR-RARP. According to the staging at magnetic resonance imaging or reconstruction, in case of cT2 prostate cancer, intrafascial nerve sparing (NS) was performed: a mark was placed on the prostate capsule to indicate the virtual underlying intraprostatic lesion; in case of cT3, standard NS AR-RARP was scheduled with AR-guided biopsy at the level of suspected extracapsular extension (ECE). Prostate specimens were scanned to assess the 3D model concordance. Sixteen patients underwent intrafascial NS technique (cT2), whereas 14 underwent standard NS+ selective biopsy of suspected ECE (cT3). Final pathology confirmed clinical staging. Positive surgical margins' rate was 30% (no positive surgical margins in pT2). In patients whose intraprostatic lesions were marked, final pathology confirmed lesion location. In patients with suspected ECE, AR-guided selective biopsies confirmed the ECE location, with 11 of 14 biopsies (78%) positive for prostate cancer. Prostate specimens were scanned with finding of a good overlap. The mismatch between 3D reconstruction and scanning ranged from 1 to 5 mm. In 85% of the entire surface, the mismatch was <3 mm. In our preliminary experience, AR-RARP seems to be safe and effective. The accuracy of 3D reconstruction seemed to be promising. This technology has still limitations: the virtual models are manually oriented and rigid. Future collaborations with bioengineers will allow overcoming these limitations. Copyright © 2018 Elsevier Inc. All rights reserved.

Gint2D-T2 correlation NMR of porous media

NASA Astrophysics Data System (ADS)

Zhang, Yan; Blümich, Bernhard

2015-03-01

The internal magnetic field gradient induced in porous media by magnetic susceptibility differences at material interfaces impacts diffusion measurements in particular at high magnetic field and can be used to probe the pore structure. Insight about the relationship between pore space and internal gradient Gint can be obtained from 2D Laplace NMR experiments. When measuring distributions of transverse relaxation times T2 in fluid filled porous media, relaxation and diffusion in internal gradients arise simultaneously and data are often interpreted with the assumption that one or the other parameter be constant throughout the sample. To examine this assumption we measure correlations of the distributions of Gint2D and T2 by 2D Laplace NMR for three different kinds of samples, glass beads with different bead diameters saturated with water, glass beads filled with oil and water, and a wet mortar sample. For the first two samples the cases where either the internal gradient or diffusion dominates were examined separately in order to better understand the relationship between Gint and D. These results are useful for assessing the impact of internal gradients and diffusion in unknown samples, such as the mortar sample. The experiments were performed at different magnetic field strengths corresponding to 300 MHz and 700 MHz 1H Larmor frequency to identify the impact of the magnetic field on the internal gradient. Subsequently, spatially resolved Gint2D-T2 maps were obtained to study the sample heterogeneity.

Monte Carlo analysis of tagged neutron beams for cargo container inspection.

PubMed

Pesente, S; Lunardon, M; Nebbia, G; Viesti, G; Sudac, D; Valkovic, V

2007-12-01

Fast neutrons produced via D+T reactions and tagged by the associated particle technique have been recently proposed to inspect cargo containers. The general characteristics of this technique are studied with Monte Carlo simulations by determining the properties of the tagged neutron beams as a function of the relevant design parameters (energy and size of the deuteron beam, geometry of the charged particle detector). Results from simulations, validated by experiments, show that the broadening of the correlation between the alpha-particle and the neutron, induced by kinematical as well as geometrical (beam and detector size) effects, is important and limits the dimension of the minimum voxel to be inspected. Moreover, the effect of the container filling is explored. The material filling produces a sizeable loss of correlation between alpha-particles and neutrons due to scattering and absorption. Conditions in inspecting cargo containers are discussed.

Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle.

PubMed

West, Adrian R; Zaman, Nishat; Cole, Darren J; Walker, Matthew J; Legant, Wesley R; Boudou, Thomas; Chen, Christopher S; Favreau, John T; Gaudette, Glenn R; Cowley, Elizabeth A; Maksym, Geoffrey N

2013-01-01

Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in other cell types that altering substrate geometry exerts potent effects on phenotype and function. These factors may be especially relevant to asthma, a disease characterized by structural remodeling of the airway wall, and highlights a need for more physiologically relevant models of ASM function. We utilized a tissue engineering platform known as microfabricated tissue gauges to develop a 3D culture model of ASM featuring arrays of ∼0.4 mm long, ∼350 cell "microtissues" capable of simultaneous contractile force measurement and cell-level microscopy. ASM-only microtissues generated baseline tension, exhibited strong cellular organization, and developed actin stress fibers, but lost structural integrity and dissociated from the cantilevers within 3 days. Addition of 3T3-fibroblasts dramatically improved survival times without affecting tension development or morphology. ASM-3T3 microtissues contracted similarly to ex vivo ASM, exhibiting reproducible responses to a range of contractile and relaxant agents. Compared with 2D cultures, microtissues demonstrated identical responses to acetylcholine and KCl, but not histamine, forskolin, or cytochalasin D, suggesting that contractility is regulated by substrate geometry. Microtissues represent a novel model for studying ASM, incorporating a physiological 3D structure, realistic mechanical environment, coculture of multiple cells types, and comparable contractile properties to existing models. This new model allows for rapid screening of biochemical and mechanical factors to provide insight into ASM dysfunction in asthma.

Is the ground state of 5d4 double-perovskite Iridate Ba2YIrO6 magnetic or nonmagnetic?

NASA Astrophysics Data System (ADS)

Gong, Hoshin; Kim, Kyoo; Kim, Beom Hyun; Kim, Bongjae; Kim, Junwon; Min, B. I.

2018-05-01

We have investigated electronic structures and magnetic properties of double perovskite Iridate Ba2YIrO6 with 5d4 configuration, employing the exact diagonalization method for multi-site clusters. We have considered a many-body Hamiltonian for all d states (eg and t2g) including all relevant physical parameters such as the Coulomb correlation, spin-orbit coupling, crystal-field effect, and Hund coupling. We have found that the ground state of Ba2YIrO6 is nonmagnetic and that the Hund coupling plays an important role in the magnetic properties of the 5d4 systems, unlike the well-studied 5d5 systems.

Overview of the Lockheed Martin Compact Fusion Reactor (CFR) Project

NASA Astrophysics Data System (ADS)

McGuire, Thomas

2017-10-01

The Lockheed Martin Compact Fusion Reactor (CFR) Program endeavors to quickly develop a compact fusion power plant with favorable commercial economics and military utility. The CFR uses a diamagnetic, high beta, magnetically encapsulated, linear ring cusp plasma confinement scheme. Major project activities will be reviewed, including the T4B and T5 plasma heating experiments. The goal of the experiments is to demonstrate a suitable plasma target for heating experiments, to characterize the behavior of plasma sources in the CFR configuration and to then heat the plasma with neutral beams, with the plasma transitioning into the high Beta confinement regime. The design and preliminary results of the experiments will be presented, including discussion of predicted behavior, plasma sources, heating mechanisms, diagnostics suite and relevant numerical modeling. ©2017 Lockheed Martin Corporation. All Rights Reserved.

Computational Design of Short Pulse Laser Driven Iron Opacity Measurements at Stellar-Relevant Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Madison E.

Opacity is a critical parameter in the simulation of radiation transport in systems such as inertial con nement fusion capsules and stars. The resolution of current disagreements between solar models and helioseismological observations would bene t from experimental validation of theoretical opacity models. Overall, short pulse laser heated iron experiments reaching stellar-relevant conditions have been designed with consideration of minimizing tamper emission and optical depth effects while meeting plasma condition and x-ray emission goals.

D-T Neutron Skyshine Experiments at JAERI/FNS

NASA Astrophysics Data System (ADS)

Nishitani, Takeo; Ochiai, Kentaro; Yoshida, Shigeo; Tanaka, Ryohei; Wakisaka, Masashi; Nakao, Makoto; Sato, Satoshi; Yamauchi, Michinori; Hori, Jun-Ichi; Takahashi, Akito; Kaneko, Jun-Ichi; Sawamura, Teruko

The D-T neutron skyshine experiments have been carried out at the Fusion Neutronics Source (FNS) of JAERI with the neutron yield of ˜1.7×1011n/s. The concrete thickness of the roof and the wall of a FNS target room are 1.15 and 2 m, respectively. The FNS skyshine port with a size of 0.9 × 0.9 m2 was open during the experimental period.The radiation dose rate outside the target room was measured as far as about 550 m away from the D-T target point with a spherical rem-counter. The highest neutron dose was about 0.5 μSv/hr at a distance of 30 m from the D-T target point and the dose rate was attenuated to 0.002 μSv/hr at a distance of 550 m. The measured neutron dose distribution was analyzed with Monte Carlo code MCNP-4B and a simple line source model. The MCNP calculation overestimates the neutron dose in the distance range larger than 250 m. The neutron spectra were evaluated with a 3He detector with different thickness of polyethylene neutron moderators. Secondary gamma-rays were measured with high purity Ge detectors and NaI scintillation detectors.

Scaling properties of fractional momentum loss of high-pT hadrons in nucleus-nucleus collisions at √{sN N} from 62.4 GeV to 2.76 TeV

NASA Astrophysics Data System (ADS)

Adare, A.; Afanasiev, S.; Aidala, C.; Ajitanand, N. N.; Akiba, Y.; Akimoto, R.; Al-Bataineh, H.; Alexander, J.; Alfred, M.; Al-Ta'Ani, H.; Angerami, A.; Aoki, K.; Apadula, N.; Aphecetche, L.; Aramaki, Y.; Armendariz, R.; Aronson, S. H.; Asai, J.; Asano, H.; Aschenauer, E. C.; Atomssa, E. T.; Averbeck, R.; Awes, T. C.; Azmoun, B.; Babintsev, V.; Bai, M.; Baksay, G.; Baksay, L.; Baldisseri, A.; Bandara, N. S.; Bannier, B.; Barish, K. N.; Barnes, P. D.; Bassalleck, B.; Basye, A. T.; Bathe, S.; Batsouli, S.; Baublis, V.; Baumann, C.; Baumgart, S.; Bazilevsky, A.; Beaumier, M.; Beckman, S.; Belikov, S.; Belmont, R.; Bennett, R.; Berdnikov, A.; Berdnikov, Y.; Bickley, A. A.; Blau, D. S.; Boissevain, J. G.; Bok, J. S.; Borel, H.; Boyle, K.; Brooks, M. L.; Bryslawskyj, J.; Buesching, H.; Bumazhnov, V.; Bunce, G.; Butsyk, S.; Camacho, C. M.; Campbell, S.; Castera, P.; Chang, B. S.; Charvet, J.-L.; Chen, C.-H.; Chernichenko, S.; Chi, C. Y.; Chiba, J.; Chiu, M.; Choi, I. J.; Choi, J. B.; Choi, S.; Choudhury, R. K.; Christiansen, P.; Chujo, T.; Chung, P.; Churyn, A.; Chvala, O.; Cianciolo, V.; Citron, Z.; Cleven, C. R.; Cole, B. A.; Comets, M. P.; Connors, M.; Constantin, P.; Csanád, M.; Csörgő, T.; Dahms, T.; Dairaku, S.; Danchev, I.; Danley, T. W.; Das, K.; Datta, A.; Daugherity, M. S.; David, G.; Deaton, M. B.; Deblasio, K.; Dehmelt, K.; Delagrange, H.; Denisov, A.; D'Enterria, D.; Deshpande, A.; Desmond, E. J.; Dharmawardane, K. V.; Dietzsch, O.; Ding, L.; Dion, A.; Diss, P. B.; Do, J. H.; Donadelli, M.; D'Orazio, L.; Drapier, O.; Drees, A.; Drees, K. A.; Dubey, A. K.; Durham, J. M.; Durum, A.; Dutta, D.; Dzhordzhadze, V.; Edwards, S.; Efremenko, Y. V.; Egdemir, J.; Ellinghaus, F.; Emam, W. S.; Engelmore, T.; Enokizono, A.; En'yo, H.; Esumi, S.; Eyser, K. O.; Fadem, B.; Feege, N.; Fields, D. E.; Finger, M.; Finger, M.; Fleuret, F.; Fokin, S. L.; Fraenkel, Z.; Frantz, J. E.; Franz, A.; Frawley, A. D.; Fujiwara, K.; Fukao, Y.; Fusayasu, T.; Gadrat, S.; Gainey, K.; Gal, C.; Gallus, P.; Garg, P.; Garishvili, A.; Garishvili, I.; Ge, H.; Giordano, F.; Glenn, A.; Gong, H.; Gong, X.; Gonin, M.; Gosset, J.; Goto, Y.; Granier de Cassagnac, R.; Grau, N.; Greene, S. V.; Grosse Perdekamp, M.; Gunji, T.; Guo, L.; Gustafsson, H.-Å.; Hachiya, T.; Hadj Henni, A.; Haegemann, C.; Haggerty, J. S.; Hahn, K. I.; Hamagaki, H.; Hamblen, J.; Hamilton, H. F.; Han, R.; Han, S. Y.; Hanks, J.; Harada, H.; Hartouni, E. P.; Haruna, K.; Hasegawa, S.; Haseler, T. O. S.; Hashimoto, K.; Haslum, E.; Hayano, R.; He, X.; Heffner, M.; Hemmick, T. K.; Hester, T.; Hiejima, H.; Hill, J. C.; Hobbs, R.; Hohlmann, M.; Hollis, R. S.; Holzmann, W.; Homma, K.; Hong, B.; Horaguchi, T.; Hori, Y.; Hornback, D.; Hoshino, T.; Hotvedt, N.; Huang, J.; Huang, S.; Ichihara, T.; Ichimiya, R.; Ide, J.; Iinuma, H.; Ikeda, Y.; Imai, K.; Imrek, J.; Inaba, M.; Inoue, Y.; Iordanova, A.; Isenhower, D.; Isenhower, L.; Ishihara, M.; Isobe, T.; Issah, M.; Isupov, A.; Ivanishchev, D.; Jacak, B. V.; Javani, M.; Jezghani, M.; Jia, J.; Jiang, X.; Jin, J.; Jinnouchi, O.; Johnson, B. M.; Joo, K. S.; Jouan, D.; Jumper, D. S.; Kajihara, F.; Kametani, S.; Kamihara, N.; Kamin, J.; Kanda, S.; Kaneta, M.; Kaneti, S.; Kang, B. H.; Kang, J. H.; Kang, J. S.; Kanou, H.; Kapustinsky, J.; Karatsu, K.; Kasai, M.; Kawall, D.; Kawashima, M.; Kazantsev, A. V.; Kempel, T.; Key, J. A.; Khachatryan, V.; Khanzadeev, A.; Kijima, K. M.; Kikuchi, J.; Kim, B. I.; Kim, C.; Kim, D. H.; Kim, D. J.; Kim, E.; Kim, E.-J.; Kim, G. W.; Kim, H. J.; Kim, K.-B.; Kim, M.; Kim, S. H.; Kim, Y.-J.; Kim, Y. K.; Kimelman, B.; Kinney, E.; Kiriluk, K.; Kiss, Á.; Kistenev, E.; Kitamura, R.; Kiyomichi, A.; Klatsky, J.; Klay, J.; Klein-Boesing, C.; Kleinjan, D.; Kline, P.; Koblesky, T.; Kochenda, L.; Kochetkov, V.; Komatsu, Y.; Komkov, B.; Konno, M.; Koster, J.; Kotchetkov, D.; Kotov, D.; Kozlov, A.; Král, A.; Kravitz, A.; Krizek, F.; Kubart, J.; Kunde, G. J.; Kurihara, N.; Kurita, K.; Kurosawa, M.; Kweon, M. J.; Kwon, Y.; Kyle, G. S.; Lacey, R.; Lai, Y. S.; Lajoie, J. G.; Lebedev, A.; Lee, B.; Lee, D. M.; Lee, J.; Lee, K.; Lee, K. B.; Lee, K. S.; Lee, M. K.; Lee, S.; Lee, S. H.; Lee, S. R.; Lee, T.; Leitch, M. J.; Leite, M. A. L.; Leitgab, M.; Leitner, E.; Lenzi, B.; Lewis, B.; Li, X.; Liebing, P.; Lim, S. H.; Linden Levy, L. A.; Liška, T.; Litvinenko, A.; Liu, H.; Liu, M. X.; Love, B.; Luechtenborg, R.; Lynch, D.; Maguire, C. F.; Makdisi, Y. I.; Makek, M.; Malakhov, A.; Malik, M. D.; Manion, A.; Manko, V. I.; Mannel, E.; Mao, Y.; Mašek, L.; Masui, H.; Masumoto, S.; Matathias, F.; McCumber, M.; McGaughey, P. L.; McGlinchey, D.; McKinney, C.; Means, N.; Meles, A.; Mendoza, M.; Meredith, B.; Miake, Y.; Mibe, T.; Mignerey, A. C.; Mikeš, P.; Miki, K.; Miller, T. E.; Milov, A.; Mioduszewski, S.; Mishra, D. K.; Mishra, M.; Mitchell, J. T.; Mitrovski, M.; Miyachi, Y.; Miyasaka, S.; Mizuno, S.; Mohanty, A. K.; Mohapatra, S.; Montuenga, P.; Moon, H. J.; Moon, T.; Morino, Y.; Morreale, A.; Morrison, D. P.; Motschwiller, S.; Moukhanova, T. V.; Mukhopadhyay, D.; Murakami, T.; Murata, J.; Mwai, A.; Nagae, T.; Nagamiya, S.; Nagashima, K.; Nagata, Y.; Nagle, J. L.; Naglis, M.; Nagy, M. I.; Nakagawa, I.; Nakagomi, H.; Nakamiya, Y.; Nakamura, K. R.; Nakamura, T.; Nakano, K.; Nattrass, C.; Nederlof, A.; Netrakanti, P. K.; Newby, J.; Nguyen, M.; Nihashi, M.; Niida, T.; Nishimura, S.; Norman, B. E.; Nouicer, R.; Novák, T.; Novitzky, N.; Nyanin, A. S.; O'Brien, E.; Oda, S. X.; Ogilvie, C. A.; Ohnishi, H.; Oka, M.; Okada, K.; Omiwade, O. O.; Onuki, Y.; Orjuela Koop, J. D.; Osborn, J. D.; Oskarsson, A.; Ouchida, M.; Ozawa, K.; Pak, R.; Pal, D.; Palounek, A. P. T.; Pantuev, V.; Papavassiliou, V.; Park, B. H.; Park, I. H.; Park, J.; Park, J. S.; Park, S.; Park, S. K.; Park, W. J.; Pate, S. F.; Patel, L.; Patel, M.; Pei, H.; Peng, J.-C.; Pereira, H.; Perepelitsa, D. V.; Perera, G. D. N.; Peresedov, V.; Peressounko, D. Yu.; Perry, J.; Petti, R.; Pinkenburg, C.; Pinson, R.; Pisani, R. P.; Proissl, M.; Purschke, M. L.; Purwar, A. K.; Qu, H.; Rak, J.; Rakotozafindrabe, A.; Ramson, B. J.; Ravinovich, I.; Read, K. F.; Rembeczki, S.; Reuter, M.; Reygers, K.; Reynolds, D.; Riabov, V.; Riabov, Y.; Richardson, E.; Rinn, T.; Roach, D.; Roche, G.; Rolnick, S. D.; Romana, A.; Rosati, M.; Rosen, C. A.; Rosendahl, S. S. E.; Rosnet, P.; Rowan, Z.; Rubin, J. G.; Rukoyatkin, P.; Ružička, P.; Rykov, V. L.; Sahlmueller, B.; Saito, N.; Sakaguchi, T.; Sakai, S.; Sakashita, K.; Sakata, H.; Sako, H.; Samsonov, V.; Sano, M.; Sano, S.; Sarsour, M.; Sato, S.; Sato, T.; Sawada, S.; Schaefer, B.; Schmoll, B. K.; Sedgwick, K.; Seele, J.; Seidl, R.; Semenov, A. Yu.; Semenov, V.; Sen, A.; Seto, R.; Sett, P.; Sexton, A.; Sharma, D.; Shein, I.; Shevel, A.; Shibata, T.-A.; Shigaki, K.; Shimomura, M.; Shoji, K.; Shukla, P.; Sickles, A.; Silva, C. L.; Silvermyr, D.; Silvestre, C.; Sim, K. S.; Singh, B. K.; Singh, C. P.; Singh, V.; Skutnik, S.; Slunečka, M.; Snowball, M.; Soldatov, A.; Soltz, R. A.; Sondheim, W. E.; Sorensen, S. P.; Sourikova, I. V.; Sparks, N. A.; Staley, F.; Stankus, P. W.; Stenlund, E.; Stepanov, M.; Ster, A.; Stoll, S. P.; Sugitate, T.; Suire, C.; Sukhanov, A.; Sumita, T.; Sun, J.; Sziklai, J.; Tabaru, T.; Takagi, S.; Takagui, E. M.; Takahara, A.; Taketani, A.; Tanabe, R.; Tanaka, Y.; Taneja, S.; Tanida, K.; Tannenbaum, M. J.; Tarafdar, S.; Taranenko, A.; Tarján, P.; Tennant, E.; Themann, H.; Thomas, T. L.; Tieulent, R.; Timilsina, A.; Todoroki, T.; Togawa, M.; Toia, A.; Tojo, J.; Tomášek, L.; Tomášek, M.; Torii, H.; Towell, C. L.; Towell, R.; Towell, R. S.; Tram, V.-N.; Tserruya, I.; Tsuchimoto, Y.; Tsuji, T.; Vale, C.; Valle, H.; van Hecke, H. W.; Vargyas, M.; Vazquez-Zambrano, E.; Veicht, A.; Velkovska, J.; Vértesi, R.; Vinogradov, A. A.; Virius, M.; Vossen, A.; Vrba, V.; Vznuzdaev, E.; Wagner, M.; Walker, D.; Wang, X. R.; Watanabe, D.; Watanabe, K.; Watanabe, Y.; Watanabe, Y. S.; Wei, F.; Wei, R.; Wessels, J.; White, A. S.; White, S. N.; Winter, D.; Wolin, S.; Wood, J. P.; Woody, C. L.; Wright, R. M.; Wysocki, M.; Xia, B.; Xie, W.; Xue, L.; Yalcin, S.; Yamaguchi, Y. L.; Yamaura, K.; Yang, R.; Yanovich, A.; Yasin, Z.; Ying, J.; Yokkaichi, S.; Yoo, J. H.; Yoon, I.; You, Z.; Young, G. R.; Younus, I.; Yu, H.; Yushmanov, I. E.; Zajc, W. A.; Zaudtke, O.; Zelenski, A.; Zhang, C.; Zhou, S.; Zimamyi, J.; Zolin, L.; Zou, L.; Phenix Collaboration

2016-02-01

Measurements of the fractional momentum loss (Sloss≡δ pT/pT ) of high-transverse-momentum-identified hadrons in heavy-ion collisions are presented. Using π0 in Au +Au and Cu +Cu collisions at √{sNN}=62.4 and 200 GeV measured by the PHENIX experiment at the Relativistic Heavy Ion Collider and and charged hadrons in Pb +Pb collisions measured by the ALICE experiment at the Large Hadron Collider, we studied the scaling properties of Sloss as a function of a number of variables: the number of participants, Npart, the number of quark participants, Nqp, the charged-particle density, d Nch/d η , and the Bjorken energy density times the equilibration time, ɛBjτ0 . We find that the pT, where Sloss has its maximum, varies both with centrality and collision energy. Above the maximum, Sloss tends to follow a power-law function with all four scaling variables. The data at √{sNN}=200 GeV and 2.76 TeV, for sufficiently high particle densities, have a common scaling of Sloss with d Nch/d η and ɛBjτ0 , lending insight into the physics of parton energy loss.

Analysis of the neutron time-of-flight spectra from inertial confinement fusion experiments

DOE PAGES

Hatarik, R.; Sayre, D. B.; Caggiano, J. A.; ...

2015-11-12

For a long time, neutron time-of-flight diagnostics been used to characterize the neutron spectrum produced by inertial confinement fusion experiments. The primary diagnostic goals are to extract the d+t→n+α (DT) and d+d→n+³He (DD) neutron yields and peak widths, and the amount DT scattering relative to its unscattered yield, which is also known as the down-scatter ratio (DSR). These quantities are used to infer yield weighted plasma conditions, such as ion temperature (T ion) and cold fuel areal density. We explain such novel methodologies used to determine neutron yield, apparent T ion and DSR.

Exploration of kinetic and multiple-ion-fluids effects in D3He and T3He gas-filled ICF implosions using multiple nuclear reaction histories

NASA Astrophysics Data System (ADS)

Sio, Hong; Rinderknecht, Hans; Rosenberg, Michael; Zylstra, Alex; Séguin, Fredrick; Gatu Johnson, Maria; Li, Chikang; Petrasso, Richard; Hoffman, Nelson; Kagan, Krigory; Molvig, Kim; Amendt, Peter; Bellei, Claudio; Wilks, Scott; Stoeckl, Christian; Glebov, Vladimir; Betti, Riccardo; Sangster, Thomas; Katz, Joseph

2014-10-01

To explore kinetic and multi-ion-fluid effects in D3He and T3He gas-filled shock-driven implosions, multiple nuclear reaction histories were measured using the upgraded Particle Temporal Diagnostic (PTD) on OMEGA. For D3He gas-filled implosions, the relative timing of the DD and D3He reaction histories were measured with 20 ps precision. For T3He gas-filled implosions (with 1-2% deuterium), the relative timing of the DT and D3He reaction histories were measured with 10 ps precision. The observed differences between the reaction histories on these two OMEGA experiments are contrasted to 1-D single-ion hydro simulations for different gas-fill pressure and gas mixture. This work is supported in part by the U.S. DOE, LLNL, LLE, and NNSA SSGF.

Developmental programming: insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep.

PubMed

Veiga-Lopez, Almudena; Lee, James S; Padmanabhan, Vasantha

2010-08-01

Prenatal testosterone (T) excess causes reproductive and metabolic disruptions including insulin resistance, attributes of women with polycystic ovary syndrome. This study tested the hypothesis that insulin resistance contributes toward severity of reproductive disruptions in prenatally T-treated females. Pregnant sheep were injected im with 100 mg of T-propionate semiweekly from d 30-90 of gestation. Immediately after the first breeding season, a subset of controls and prenatal T-treated (TR) sheep were administered an insulin sensitizer (rosiglitazone; 8 mg/d) orally for 8 months. Untreated control and prenatal T-treated females (T group) were studied in parallel. Biochemical analyses revealed rosiglitazone to be safe for use in sheep. Glucose tolerance tests performed before and after the insulin sensitizer treatment found that insulin sensitizer decreased cumulative insulin, cumulative insulin/glucose ratio, and insulin area under the curve by about 50% and increased the insulin sensitivity index by about 70% in the TR compared with the T group. Twenty percent of TR females showed a reduced number of cycles in the second relative to first breeding season as opposed to 80% of T group females showing such deterioration. Insulin sensitizer treatment also decreased the number of aberrant cycles (>/=18 d) during the second breeding season in the TR group relative to the first as opposed to the T group females showing an increase in the second breeding season relative to the first. These findings provide evidence that insulin sensitizer treatment prevents further deterioration of the reproductive axis in prenatal T-treated sheep, a finding of translational relevance to women with polycystic ovary syndrome.

Evidence of final-state suppression of high-p{_ T} hadrons in Au + Au collisions using d + Au measurements at RHIC

NASA Astrophysics Data System (ADS)

Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Becker, B.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Harrington, A. S.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lee, J. W.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Pernegger, H.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Sarin, P.; Sedykh, I.; Skulski, W.; Smith, C. E.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Verdier, R.; Veres, G. I.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wysłouch, B.; Zhang, J.

Transverse momentum spectra of charged hadrons with pT < 6 GeV/c have been measured near mid-rapidity (0.2 < ɛ < 1.4) by the PHOBOS experiment at RHIC in Au + Au and d + Au collisions at {√ {s{NN}} = {200 GeV}}. The spectra for different collision centralities are compared to {p + ¯ {p}} collisions at the same energy. The resulting nuclear modification factor for central Au + Au collisions shows evidence of strong suppression of charged hadrons in the high-pT region (>2 GeV/c). In contrast, the d + Au nuclear modification factor exhibits no suppression of the high-pT yields. These measurements suggest a large energy loss of the high-pT particles in the highly interacting medium created in the central Au + Au collisions. The lack of suppression in d + Au collisions suggests that it is unlikely that initial state effects can explain the suppression in the central Au + Au collisions. PACS: 25.75.-q

Field warming experiments shed light on the wheat yield response to temperature in China

PubMed Central

Zhao, Chuang; Piao, Shilong; Huang, Yao; Wang, Xuhui; Ciais, Philippe; Huang, Mengtian; Zeng, Zhenzhong; Peng, Shushi

2016-01-01

Wheat growth is sensitive to temperature, but the effect of future warming on yield is uncertain. Here, focusing on China, we compiled 46 observations of the sensitivity of wheat yield to temperature change (SY,T, yield change per °C) from field warming experiments and 102 SY,T estimates from local process-based and statistical models. The average SY,T from field warming experiments, local process-based models and statistical models is −0.7±7.8(±s.d.)% per °C, −5.7±6.5% per °C and 0.4±4.4% per °C, respectively. Moreover, SY,T is different across regions and warming experiments indicate positive SY,T values in regions where growing-season mean temperature is low, and water supply is not limiting, and negative values elsewhere. Gridded crop model simulations from the Inter-Sectoral Impact Model Intercomparison Project appear to capture the spatial pattern of SY,T deduced from warming observations. These results from local manipulative experiments could be used to improve crop models in the future. PMID:27853151

The DoD Gateway Information System: Bibliography, Directory of Resources, Prototype Experience, [and] User Interface Design.

ERIC Educational Resources Information Center

Cotter, Gladys A.; And Others

The Defense Technical Information Center (DTIC), an organization charged with providing information services to the Department of Defense (DoD) scientific and technical community, actively seeks ways to promote access to and utilization of scientific and technical information (STI) databases, online services, and networks relevant to the conduct…

Bootstrapping 3D fermions

DOE PAGES

Iliesiu, Luca; Kos, Filip; Poland, David; ...

2016-03-17

We study the conformal bootstrap for a 4-point function of fermions in 3D. We first introduce an embedding formalism for 3D spinors and compute the conformal blocks appearing in fermion 4-point functions. Using these results, we find general bounds on the dimensions of operators appearing in the ψ × ψ OPE, and also on the central charge C T. We observe features in our bounds that coincide with scaling dimensions in the GrossNeveu models at large N. Finally, we also speculate that other features could coincide with a fermionic CFT containing no relevant scalar operators.

U.S. Navy Officer Attitudes on the Repeal of Don’t Ask, Don’t Tell

DTIC Science & Technology

2013-03-01

military units; a pre- test / post - test quasi experiment; survey analysis; relevant media analysis of articles related to the repeal and published within...and 2010. The surveys revealed an increasing acceptance of gays in the Navy. The present study, conducted post - repeal, utilized the same NPS survey...and enlisted personnel. Further, the post -repeal effects on readiness should be monitored, particularly for fairness and potential harassment. The

Counting spinning dyons in maximal supergravity: the Hodge-elliptic genus for tori

NASA Astrophysics Data System (ADS)

Benjamin, Nathan; Kachru, Shamit; Tripathy, Arnav

2017-11-01

We consider M-theory compactified on T^4 × T^2 and describe the count of spinning 1/8-BPS states. This builds on the work of Maldacena-Moore-Strominger in the physics literature. It simultaneously provides a refinement of the recent mathematical work of Bryan-Oberdieck-Pandharipande-Yin and Oberdieck-Shen, which studied (non-motivic) reduced Donaldson-Thomas invariants of abelian surfaces and threefolds. As in previous work on K3 × T^2 compactification, we track angular momenta under both the SU(2)_L and SU(2)_R factors in the 5d little group, providing predictions for the relevant motivic curve counts.

Issues in Turbulence Simulation for Experimental Comparison

NASA Astrophysics Data System (ADS)

Ross, D. W.; Bravenec, R. V.; Dorland, W.; Beer, M. A.; Hammett, G. W.

1999-11-01

Studies of the sensitivity of fluctuation spectra and transport fluxes to local plasma parameters and gradients(D. W. Ross et al.), Bull. Am. Phys. Soc. 43, 1760 (1998); D. W. Ross et al., Transport Task Force Workshop, Portland, Oregon, (1999). are continued using nonlinear gyrofluid simulation(M. A. Beer et al.), Phys. Plasmas 2, 2687 (1995). on the T3E at NERSC. Parameters that are characteristic of discharges in DIII-D and Alcator C-Mod are employed. In the previous work, the gradients of Z_eff, n_e, and Te were varied within the experimental uncertainty. Amplitudes and fluxes are quite sensitive to dZ_eff/dr. Here, these studies are continued and extended to variation of other parameters, including T_e/T_i, and dT_i/dr, which are important for ion temperature gradient modes. The role of electric field shear is discussed. Implications for comparison with experiment, including transient perturbations, are discussed, with the goal of quantifying the accuracy of profile data needed to verify the turbulence theory.

Thermodynamics of superconducting Nb3Al, Nb3Ge, Nb3Sn, and V3Ga

NASA Astrophysics Data System (ADS)

Mitrović, B.; Schachinger, E.; Carbotte, J. P.

1984-06-01

We have calculated the superconducting thermodynamic properties for several high-transition-temperature A15 compounds: Nb-Al, Nb-Ge, Nb-Sn, and V-Ga. In our calculations we have used the tunneling electron-phonon-coupling spectra α2F for all four systems considered, and in the case of Nb-Al and Nb-Ge we have also used α2F=CG, where G is the measured generalized phonon density of states and C is a constant. We find that all Nb-based A15 compounds display similar thermodynamic properties, which do not depend explicitly on the band density of states: 2Δ0κBTc≅4.6, ΔCγTc≅2.5-2.6,-Tc[dHc(T)dT]TcHc(0)≅2.1, γ[TcHc(0)]2≅0.134, and positive D(t)'s with the maximum value around 0.02. For Nb3Sn we find good agreement between the calculated properties and the old specific-heat experimental results (γ≅52 mJ/mol K2). The same applies to V3Ga, where the theoretical results have been compared with the experiments of Junod et al. However, we do not find good agreement between calculated ΔCγTc, - Tc[dHc(T)dT]TcHc(0), γ[TcHc(0)]2, and experimental values for Nb3Al and Nb3Ge, presumably due to broadened transitions. It is argued that the tunneling experiments underestimate the value of the gap which should be associated with the inverted α2F.

Perspectives on Long-Distance Air Travel with Type 1 Diabetes.

PubMed

Pinsker, Jordan E; Schoenberg, Benjamen E; Garey, Colleen; Runion, Asher; Larez, Arianna; Kerr, David

2017-12-01

We sought to determine the real-life experiences of individuals traveling long distance (across five or more time-zones) with type 1 diabetes (T1D). Five hundred three members of the T1D Exchange online community ( www.myglu.org ) completed a 45-question survey about their travel experiences flying long distance. The cohort was stratified by duration of T1D and whether or not participants used continuous subcutaneous insulin infusion (CSII) therapy and/or a continuous glucose monitor (CGM). In the last 5 years, 71% of participants had flown long distance. When asked about their perceived "fear of flying," CSII users (with and without a CGM) reported their primary anxiety was "losing supplies," while non-CSII users described concerns over "unstable blood glucose (highs and lows)" (P < 0.05). In addition, 74% of participants reported more hypoglycemia and/or hyperglycemia while traveling overseas and 9% had avoided international travel altogether because of problems related to diabetes management. Furthermore, 22% of participants had run out of insulin at some point during a trip and 37% reported inadequate attention in current sources of information to the unpredictability of self-management needs while traveling. Especially problematic for individuals traveling with T1D are a lack of resources adequately addressing (1) protocols for emergencies while abroad, (2) how to navigate airport security, and (3) managing basal insulin rates when crossing time zones. A strong need exists for easily accessible, free resources for traveling with T1D that is tailored to both device use and duration of the disease.

Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.

PubMed

Yang, Zhiliang; Matsumoto, Ayumi; Nakayama, Kazuhiro; Jimbo, Eriko F; Kojima, Karin; Nagata, Koh-ichi; Iwamoto, Sadahiko; Yamagata, Takanori

2016-01-01

The genetic background of autism spectrum disorder (ASD) is considered a multi-genetic disorder with high heritability. Autistic children present with a higher prevalence of sleep disorders than has been observed in children with normal development. Some circadian-relevant genes have been associated with ASD (e.g., PER1, PER2, NPAS2, MTNR1A, and MTNR1B). We analyzed 28 ASD patients (14 with sleep disorders and 14 without) and 23 control subjects of Japanese descent. The coding regions of 18 canonical clock genes and clock-controlled genes were sequenced. Detected mutations were verified by direct sequencing analysis, and additional control individuals were screened. Thirty-six base changes with amino acid changes were detected in 11 genes. Six missense changes were detected only in individuals with ASD with sleep disturbance: p.F498S in TIMELESS, p.S20R in NR1D1, p.R493C in PER3, p.H542R in CLOCK, p.L473S in ARNTL2, and p.A325V in MTNR1B. Six missense changes were detected only in individuals with ASD without sleep disturbance: p.S1241N in PER1, p.A325T in TIMELESS, p.S13T in ARNTL, p.G24E in MTNR1B, p.G24E in PER2, and p.T1177A in PER3. The p.R493C mutation in PER3 was detected in both groups. One missense change, p.P932L in PER2, was detected only in the control group. Mutations in NR1D1, CLOCK, and ARNTL2 were detected only in individuals with ASD with sleep disorder. The prevalence of the mutations detected only single time differed significantly among all ASD patients and controls (p=0.003). Two kinds of mutations detected only in individuals with ASD with sleep disorder, p.F498S in TIMELESS and p.R366Q in PER3, were considered to affect gene function by three different methods: PolyPhen-2, scale-invariant feature transform (SIFT) prediction, and Mutation Taster (www.mutationtaster.org). The mutations p.S20R in NR1D1, p.H542R in CLOCK, p.L473S in ARNTL2, p.A325T in TIMELESS, p.S13T in ARNTL, and p.G24E in PER2 were diagnosed to negatively affect gene function by more than one of these methods. Mutations in circadian-relevant genes affecting gene function are more frequent in patients with ASD than in controls. Circadian-relevant genes may be involved in the psychopathology of ASD. Copyright © 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Prognostic Value of EEG Microstates in Acute Stroke.

PubMed

Zappasodi, Filippo; Croce, Pierpaolo; Giordani, Alessandro; Assenza, Giovanni; Giannantoni, Nadia M; Profice, Paolo; Granata, Giuseppe; Rossini, Paolo M; Tecchio, Franca

2017-09-01

Given the importance of neuronal plasticity in recovery from a stroke and the huge variability of recovery abilities in patients, we investigated neuronal activity in the acute phase to enhance information about the prognosis of recovery in the stabilized phase. We investigated the microstates in 47 patients who suffered a first-ever mono-lesional ischemic stroke in the middle cerebral artery territory and in 20 healthy control volunteers. Electroencephalographic (EEG) activity at rest with eyes closed was acquired between 2 and 10 days (T0) after ischemic attack. Objective criteria allowed for the selection of an optimal number of microstates. Clinical condition was quantified by the National Institute of Health Stroke Scale (NIHSS) both in acute (T0) and stabilized (T1, 5.4 ± 1.7 months) phases and Effective Recovery (ER) was calculated as (NIHSS(T1)-NIHSS(T0))/NIHSS(T0). The microstates A, B, C and D emerged as the most stable. In patients with a left lesion inducing a language impairment, microstate C topography differed from controls. Microstate D topography was different in patients with a right lesion inducing neglect symptoms. In patients, the C vs D microstate duration differed after both a left and a right lesion with respect to controls (C lower than D in left and D lower than C in right lesion). A preserved microstate B in acute phase correlated with a better effective recovery. A regression model indicated that the microstate B duration explained the 11% of ER variance. This first ever study of EEG microstates in acute stroke opens an interesting path to identify neuronal impairments with prognostic relevance, to develop enriched compensatory treatments to drive a better individual recovery.

Let Care Shine Through

ERIC Educational Resources Information Center

Bondy, Elizabeth; Hambacher, Elyse

2016-01-01

Care is in the eyes of the receiver; it doesn't exist unless those being cared for experience it. The authors describe culturally relevant critical teacher care, an approach that considers the effects of students' cultural and socioeconomic conditions and that helps teachers find ways to show care to every learner--especially those from oppressed…

Superconductivity and bandwidth-controlled Mott metal-insulator transition in 1T-TaS2-xSex

NASA Astrophysics Data System (ADS)

Ang, R.; Miyata, Y.; Ieki, E.; Nakayama, K.; Sato, T.; Liu, Y.; Lu, W. J.; Sun, Y. P.; Takahashi, T.

2013-09-01

We have performed high-resolution angle-resolved photoemission spectroscopy (ARPES) of layered chalcogenide 1T-TaS2-xSex to elucidate the electronic states especially relevant to the occurrence of superconductivity. We found a direct evidence for a Ta-5d-derived electron pocket associated with the superconductivity, which is fragile against a Mott-gap opening observed in the insulating ground state for S-rich samples. In particular, a strong electron-electron interaction-induced Mott gap driven by a Ta 5d orbital also exists in the metallic ground state for Se-rich samples, while finite ARPES intensity near the Fermi level likely originating from a Se 4p orbital survives, indicative of the orbital-selective nature of the Mott transition. Present results suggest that effective electron correlation and p-d hybridization play a crucial role to tune the superconductivity and Mott metal-insulator transition.

Measurement of D0 Azimuthal Anisotropy at Midrapidity in Au +Au Collisions at √{sN N }=200 GeV

NASA Astrophysics Data System (ADS)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Ajitanand, N. N.; Alekseev, I.; Anderson, D. M.; Aoyama, R.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Ashraf, M. U.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Behera, A.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Brown, D.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chankova-Bunzarova, N.; Chatterjee, A.; Chattopadhyay, S.; Chen, X.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Elsey, N.; Engelage, J.; Eppley, G.; Esha, R.; Esumi, S.; Evdokimov, O.; Ewigleben, J.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Federicova, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Finch, E.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, A.; Gupta, S.; Guryn, W.; Hamad, A. I.; Hamed, A.; Harlenderova, A.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, B.; Huang, X.; Huang, H. Z.; Humanic, T. J.; Huo, P.; Igo, G.; Jacobs, W. W.; Jentsch, A.; Jia, J.; Jiang, K.; Jowzaee, S.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Kocmanek, M.; Kollegger, T.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kulathunga, N.; Kumar, L.; Kvapil, J.; Kwasizur, J. H.; Lacey, R.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, W.; Li, Y.; Lidrych, J.; Lin, T.; Lisa, M. A.; Liu, H.; Liu, P.; Liu, Y.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, S.; Luo, X.; Ma, G. L.; Ma, L.; Ma, Y. G.; Ma, R.; Magdy, N.; Majka, R.; Mallick, D.; Margetis, S.; Markert, C.; Matis, H. S.; Meehan, K.; Mei, J. C.; Miller, Z. W.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mizuno, S.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nasim, Md.; Nayak, T. K.; Nelson, J. M.; Nie, M.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Nonaka, T.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Przybycien, M.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Ray, R. L.; Reed, R.; Rehbein, M. J.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Roth, J. D.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Salur, S.; Sandweiss, J.; Saur, M.; Schambach, J.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Schweid, B. R.; Seger, J.; Sergeeva, M.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, A.; Sharma, M. K.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Strikhanov, M.; Stringfellow, B.; Sugiura, T.; Sumbera, M.; Summa, B.; Sun, Y.; Sun, X. M.; Sun, X.; Surrow, B.; Svirida, D. N.; Szelezniak, M. A.; Tang, A. H.; Tang, Z.; Taranenko, A.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Trzeciak, B. A.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vasiliev, A. N.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, G.; Wang, Y.; Wang, F.; Wang, Y.; Webb, J. C.; Webb, G.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xu, J.; Xu, N.; Xu, Q. H.; Xu, Y. F.; Xu, Z.; Yang, Y.; Yang, Q.; Yang, C.; Yang, S.; Ye, Z.; Ye, Z.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, Z.; Zhang, X. P.; Zhang, J. B.; Zhang, S.; Zhang, J.; Zhang, Y.; Zhang, J.; Zhang, S.; Zhao, J.; Zhong, C.; Zhou, L.; Zhou, C.; Zhu, X.; Zhu, Z.; Zyzak, M.; STAR Collaboration

2017-05-01

We report the first measurement of the elliptic anisotropy (v2) of the charm meson D0 at midrapidity (|y |<1 ) in Au +Au collisions at √{sN N}=200 GeV . The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D0 v2 in 0%-80% centrality Au +Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (pT) of less than 4 GeV /c . The D0 v2 as a function of transverse kinetic energy (mT-m0, where mT=√{pT2+m02 }) is consistent with that of light mesons in 10%-40% centrality Au +Au collisions. These results suggest that charm quarks have achieved local thermal equilibrium with the medium created in such collisions. Several theoretical models, with the temperature-dependent, dimensionless charm spatial diffusion coefficient (2 π T Ds) in the range of ˜2 - 12 , are able to simultaneously reproduce our D0 v2 result and our previously published results for the D0 nuclear modification factor.

Penetration experiments in aluminum and Teflon targets of widely variable thickness

NASA Technical Reports Server (NTRS)

Hoerz, F.; Cintala, Mark J.; Bernhard, R. P.; See, T. H.

1994-01-01

The morphologies and detailed dimensions of hypervelocity craters and penetration holes on space-exposed surfaces faithfully reflect the initial impact conditions. However, current understanding of this postmortem evidence and its relation to such first-order parameters as impact velocity or projectile size and mass is incomplete. While considerable progress is being made in the numerical simulation of impact events, continued impact simulations in the laboratory are needed to obtain empirical constraints and insights. This contribution summarizes such experiments with Al and Teflon targets that were carried out in order to provide a better understanding of the crater and penetration holes reported from the Solar Maximum Mission (SMM) and the Long Duration Exposure Facility (LDEF) satellites. A 5-mm light gas gun was used to fire spherical soda-lime glass projectiles from 50 to 3175 microns in diameter (D(sub P)), at a nominal 6 km/s, into Al (1100 series; annealed) and Teflon (Teflon(sup TFE)) targets. Targets ranged in thickness (T) from infinite halfspace targets (T approx. equals cm) to ultrathin foils (T approx. equals micron), yielding up to 3 degrees of magnitude variation in absolute and relative (D(sub P)/T) target thickness. This experimental matrix simulates the wide range in D(sub P)/T experienced by a space-exposed membrane of constant T that is being impacted by projectiles of widely varying sizes.

Polar-Drive Experiments at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Hohenberger, M.

2014-10-01

To support direct-drive inertial confinement fusion (ICF) experiments at the National Ignition Facility (NIF) in its indirect-drive beam configuration, the polar-drive (PD) concept has been proposed. It requires direct-drive-specific beam smoothing, phase plates, and repointing the NIF beams toward the equator to ensure symmetric target irradiation. First experiments testing the performance of ignition-relevant PD implosions at the NIF have been performed. The goal of these early experiments was to develop a stable, warm implosion platform to investigate laser deposition and laser-plasma instabilities at ignition-relevant plasma conditions, and to develop and validate ignition-relevant models of laser deposition and heat conduction. These experiments utilize the NIF in its current configuration, including beam geometry, phase plates, and beam smoothing. Warm, 2.2-mm-diam plastic shells were imploded with total drive energies ranging from ~ 350 to 750 kJ with peak powers of 60 to 180 TW and peak on-target intensities from 4 ×1014 to 1 . 2 ×1015 W/cm2. Results from these initial experiments are presented, including the level of hot-electron preheat, and implosion symmetry and shell trajectory inferred via self-emission imaging and backlighting. Experiments are simulated with the 2-D hydrodynamics code DRACO including a full 3-D ray trace to model oblique beams, and a model for cross-beam energy transfer (CBET). These simulations indicate that CBET affects the shell symmetry and leads to a loss of energy imparted onto the shell, consistent with the experimental data. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

Monte Carlo modeling the phase diagram of magnets with the Dzyaloshinskii - Moriya interaction

NASA Astrophysics Data System (ADS)

Belemuk, A. M.; Stishov, S. M.

2017-11-01

We use classical Monte Carlo calculations to model the high-pressure behavior of the phase transition in the helical magnets. We vary values of the exchange interaction constant J and the Dzyaloshinskii-Moriya interaction constant D, which is equivalent to changing spin-spin distances, as occurs in real systems under pressure. The system under study is self-similar at D / J = constant , and its properties are defined by the single variable J / T , where T is temperature. The existence of the first order phase transition critically depends on the ratio D / J . A variation of J strongly affects the phase transition temperature and width of the fluctuation region (the ;hump;) as follows from the system self-similarity. The high-pressure behavior of the spin system depends on the evolution of the interaction constants J and D on compression. Our calculations are relevant to the high pressure phase diagrams of helical magnets MnSi and Cu2OSeO3.

[APPLICATION OF THREE DIMENSIONAL PRINTING ON MANUFACTURING BIONIC SCAFFOLDS OF SPINAL CORD IN RATS].

PubMed

Chen, Yisheng; Wang, Jingjing; Chen, Xuyi; Chen, Chong; Tu, Yue; Zhang, Sai; Li, Xiaohong

2015-03-01

To fabricate the bionic scaffolds of rat spinal cord by combining three dimensional (3D) printer and 3D software, so as to lay the foundation of theory and technology for the manufacture of scaffolds by using biomaterials. Three female Sprague Dawley rats were scanned by 7.0T MRI to obtain the shape and position data of the cross section and gray matter of T8 to T10 spinal cord. Combined with data of position and shape of nerve conduction beam, the relevant data were obtained via Getdata software. Then the 3D graphics were made and converted to stereolithography (STL) format by using SolidWorks software. Photosensitive resin was used as the materials of spinal cord scaffolds. The bionic scaffolds were fabricated by 3D printer. MRI showed that the section shape of T8 to T10 segments of the spinal cord were approximately oval with a relatively long sagittal diameter of (2.20 ± 0.52) mm and short transverse diameter of (2.05 ± 0.24) mm, and the data of nerve conduction bundle were featured in the STL format. The spinal cord bionic scaffolds of the target segments made by 3D printer were similar to the spinal cord of rat in the morphology and size, and the position of pores simulated normal nerve conduction of rat spinal cord. Spinal cord scaffolds produced by 3D printer which have similar shape and size of normal rat spinal cord are more bionic, and the procedure is simple. This technology combined with biomaterials is also promising in spinal cord repairing after spinal cord injury.

Anomalous DD and TT yields relative to the DT yield in inertial-confinement-fusion implosions

NASA Astrophysics Data System (ADS)

Casey, Daniel T.

2011-10-01

Measurements of the D(d,p)T (DD), T(t,2n)4He (TT) and D(t,n)4He (DT) reactions have been conducted using deuterium-tritium gas-filled inertial confinement fusion (ICF) implosions. In these experiments, which were carried out at the OMEGA laser facility, absolute spectral measurements of the DD protons and TT neutrons were conducted and compared to neutron-time-of-flight measured DT-neutron yields. From these measurements, it is concluded that the DD yield is anomalously low and the TT yield is anomalously high relative to the DT yield, an effect that is enhanced with increasing ion temperature. These results can be explained by an enrichment of tritium in the core of an ICF implosion, which may be present in ignition experiments planned on the National Ignition Facility. In addition, the spectral measurements of the TT-neutron spectrum were conducted for the first time at reactant central-mass energies in the range of 15-30 keV. The results from these measurements indicate that the TT reaction proceeds primarily through the direct three-body reaction channel, producing a continuous TT-neutron spectrum in the range 0 - 9.5 MeV. This work was conducted in collaboration with J. A. Frenje, M. Gatu Johnson, M. J.-E. Manuel, H. G. Rinderknecht, N. Sinenian, F. H. Seguin, C. K. Li, R. D. Petrasso, P. B. Radha, J. A. Delettrez, V. Yu Glebov, D. D. Meyerhofer, T. C. Sangster, D. P. McNabb, P. A. Amendt, R. N. Boyd, J. R. Rygg, H. W. Herrmann, Y. H. Kim, G. P. Grim and A. D. Bacher. This work was supported in part by the U.S. Department of Energy (Grant No. DE-FG03-03SF22691), LLE (subcontract Grant No. 412160-001G), LLNL (subcontract Grant No. B504974).

Cross-section measurement of 7Be + d and 7Li + d with ANASEN* and its implication in the Big Bang Nucleosynthesis

NASA Astrophysics Data System (ADS)

Rijal, Nabin; Wiedenhover, Ingo; Baby, L. T.; Blackmon, J. C.; Rogachev, G.

2017-09-01

Astrophysically observed 7Li is 3 -4 times less than predicted amount by current models of Standard Big Bang Nucleosynthesis (SBBN). The nuclear reaction 7Be + d at energies relevant to SBBN, has been discussed as a possible means to destroy mass-7 nuclei. We investigated the 7Be + d and it's mirror nuclear reaction 7Li + d at SBBN energies using a radioactive 7Be and stable 7Li beam both in deuterium gas target inside ANASEN at Florida State University. ANASEN is an active target detector system which tracks the charged particles using a position sensitive proportional counter and 24-SX3 and 4-QQQ position sensitive Silicon detectors, all backed up by CsI detectors. ANASEN has wide angular coverage. The experiment measures a continuous excitation function by slowing down the beam in the target gas down to zero energy by using a single beam energy. Our set-up provides a high detection efficiency for all relevant reaction channels including (d , p) , (d , α) and/or direct breakup that can destroy mass-7 nuclei in contrast to previous measurements. The preliminary results of these experiments along with details of ANASEN detector will be presented. *ANASEN: Array for Nuclear Astrophysics and Structure with Exotic Nuclei. This work is supported by the US NSF MRI program, Grant No. PHY-0821308 and NSF Grant PHY-1401574.

17DD and 17D-213/77 yellow fever substrains trigger a balanced cytokine profile in primary vaccinated children.

PubMed

Campi-Azevedo, Ana Carolina; de Araújo-Porto, Luiza Pacheco; Luiza-Silva, Maria; Batista, Maurício Azevedo; Martins, Marina Angela; Sathler-Avelar, Renato; da Silveira-Lemos, Denise; Camacho, Luiz Antonio Bastos; de Menezes Martins, Reinaldo; de Lourdes de Sousa Maia, Maria; Farias, Roberto Henrique Guedes; da Silva Freire, Marcos; Galler, Ricardo; Homma, Akira; Ribeiro, José Geraldo Leite; Lemos, Jandira Aparecida Campos; Auxiliadora-Martins, Maria; Caldas, Iramaya Rodrigues; Elói-Santos, Silvana Maria; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis

2012-01-01

This study aimed to compare the cytokine-mediated immune response in children submitted to primary vaccination with the YF-17D-213/77 or YF-17DD yellow fever (YF) substrains. A non-probabilistic sample of eighty healthy primary vaccinated (PV) children was selected on the basis of their previously known humoral immune response to the YF vaccines. The selected children were categorized according to their YF-neutralizing antibody titers (PRNT) and referred to as seroconverters (PV-PRNT(+)) or nonseroconverters (PV-PRNT(-)). Following revaccination with the YF-17DD, the PV-PRNT(-) children (YF-17D-213/77 and YF-17DD groups) seroconverted and were referred as RV-PRNT(+). The cytokine-mediated immune response was investigated after short-term in vitro cultures of whole blood samples. The results are expressed as frequency of high cytokine producers, taking the global median of the cytokine index (YF-Ag/control) as the cut-off. The YF-17D-213/77 and the YF-17DD substrains triggered a balanced overall inflammatory/regulatory cytokine pattern in PV-PRNT(+), with a slight predominance of IL-12 in YF-17DD vaccinees and a modest prevalence of IL-10 in YF-17D-213/77. Prominent frequency of neutrophil-derived TNF-α and neutrophils and monocyte-producing IL-12 were the major features of PV-PRNT(+) in the YF-17DD, whereas relevant inflammatory response, mediated by IL-12(+)CD8(+) T cells, was the hallmark of the YF-17D-213/77 vaccinees. Both substrains were able to elicit particular but relevant inflammatory events, regardless of the anti-YF PRNT antibody levels. PV-PRNT(-) children belonging to the YF-17DD arm presented gaps in the inflammatory cytokine signature, especially in terms of the innate immunity, whereas in the YF-17D-213/77 arm the most relevant gap was the deficiency of IL-12-producing CD8(+)T cells. Revaccination with YF-17DD prompted a balanced cytokine profile in YF-17DD nonresponders and a robust inflammatory profile in YF-17D-213/77 nonresponders. Our findings demonstrated that, just like the YF-17DD reference vaccine, the YF-17D-213/77 seed lot induced a mixed pattern of inflammatory and regulatory cytokines, supporting its universal use for immunization.

Dependence of Coronary 3-Dimensional Dose Maps on Coronary Topologies and Beam Set in Breast Radiation Therapy: A Study Based on CT Angiographies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moignier, Alexandra, E-mail: alexandra.moignier@gmail.com; Broggio, David; Derreumaux, Sylvie

2014-05-01

Purpose: In left-side breast radiation therapy (RT), doses to the left main (LM) and left anterior descending (LAD) coronary arteries are usually assessed after delineation by prior anatomic knowledge on the treatment planning computed tomography (CT) scan. In this study, dose sensitivity due to interindividual coronary topology variation was assessed, and hot spots were located. Methods and Materials: Twenty-two detailed heart models, created from heart computed tomography angiographies, were fitted into a single representative female thorax. Two breast RT protocols were then simulated into a treatment planning system: the first protocol comprised tangential and tumoral bed beams (TGs{sub T}B) atmore » 50 + 16 Gy, the second protocol added internal mammary chain beams at 50 Gy to TGs{sub T}B (TGs{sub T}B{sub I}MC). For the heart, the LAD, and the LM, several dose indicators were calculated: dose-volume histograms, mean dose (D{sub mean}), minimal dose received by the most irradiated 2% of the volume (D{sub 2%}), and 3-dimensional (3D) dose maps. Variations of these indicators with anatomies were studied. Results: For the LM, the intermodel dispersion of D{sub mean} and D{sub 2%} was 10% and 11%, respectively, with TGs{sub T}B and 40% and 80%, respectively, with TGs{sub T}B{sub I}MC. For the LAD, these dispersions were 19% (D{sub mean}) and 49% (D{sub 2%}) with TGs{sub T}B and 35% (D{sub mean}) and 76% (D{sub 2%}) with TGs{sub T}B{sub I}MC. The 3D dose maps revealed that the internal mammary chain beams induced hot spots between 20 and 30 Gy on the LM and the proximal LAD for some coronary topologies. Without IMC beams, hot spots between 5 and 26 Gy are located on the middle and distal LAD. Conclusions: Coronary dose distributions with hot spot location and dose level can change significantly depending on coronary topology, as highlighted by 3D coronary dose maps. In clinical practice, coronary imaging may be required for a relevant coronary dose assessment, especially in cases of internal mammary chain irradiation.« less

Blur-resistant Perimetric Stimuli

PubMed Central

Horner, Douglas G.; Dul, Mitchell W.; Swanson, William H.; Liu, Tiffany; Tran, Irene

2013-01-01

Purpose To develop perimetric stimuli which are resistant to the effects of peripheral defocus. Methods One eye each was tested on subjects free of eye disease. Experiment 1 assessed spatial frequency, testing 12 subjects at eccentricities from 2° to 7°, using blur levels from 0 D to 3 D for two (Gabor) stimuli (spatial standard deviation (SD) = 0.5°, spatial frequencies of 0.5 and 1.0 cpd). Experiment 2 assessed stimulus size, testing 12 subjects at eccentricities from 4° to 7°, using blur levels 0 D to 6 D, for two Gaussians with SDs of 0.5° and 0.25° and a 0.5 cpd Gabor with SD of 0.5°. Experiment 3 tested 13 subjects at eccentricities from fixation to 27°, using blur levels 0 D to 6 D, for Gabor stimuli at 56 locations; the spatial frequency ranged from 0.14 to 0.50 cpd with location, and SD was scaled accordingly. Results In experiment 1, blur by 3 D caused a small decline in log contrast sensitivity (CS) for the 0.5 cpd stimulus (mean ± SE = −0.09 ± 0.08 log unit) and a larger (t = 7.7, p <0.0001) decline for the 1.0 cpd stimulus (0.37 ± 0.13 log unit). In experiment 2, blur by 6 D caused minimal decline for the larger Gaussian, by −0.17 ± 0.16 log unit, and larger (t >4.5, p < 0.001) declines for the smaller Gaussian (−0.33 ± 0.16 log unit) and the Gabor (−0.36 ± 0.18 log unit). In experiment 3, blur by 6 D caused declines by 0.27 ± 0.05 log unit for eccentricities from 0° to 10°, by 0.20 ± 0.04 log unit for eccentricities from 10° to 20° and 0.13 ± 0.03 log unit for eccentricities from 20°–27°. Conclusions Experiments 1 & 2 allowed us to design stimuli for Experiment 3 that were resistant to effects of peripheral defocus. PMID:23584488

The strategy and motivational influences on the beneficial effect of neurostimulation: a tDCS and fNIRS study

PubMed Central

Jones, Kevin T.; Gözenman, Filiz; Berryhill, Marian E.

2014-01-01

Working memory (WM) capacity falls along a spectrum with some people demonstrating higher and others lower WM capacity. Efforts to improve WM include applying transcranial direct current stimulation (tDCS), in which small amounts of current modulate the activity of underlying neurons and enhance cognitive function. However, not everyone benefits equally from a given tDCS protocol. Recent findings revealed tDCS-related WM benefits for individuals with higher working memory (WM) capacity. Here, we test two hypotheses regarding those with low WM capacity to see if they too would benefit under more optimal conditions. We tested whether supplying a WM strategy (Experiment 1) or providing greater extrinsic motivation through incentives (Experiment 2) would restore tDCS benefit to the low WM capacity group. We also employed functional near infrared spectroscopy to monitor tDCS-induced changes in neural activity. Experiment 1 demonstrated that supplying a WM strategy improved the high WM capacity participants’ accuracy and the amount of oxygenated blood levels following anodal tDCS, but it did not restore tDCS-linked WM benefits to the low WM capacity group. Experiment 2 demonstrated that financial motivation enhanced performance in both low and high WM capacity groups, especially after anodal tDCS. Here, only the low WM capacity participants showed a generalized increase in oxygenated blood flow across both low and high motivation conditions. These results indicate that ensuring that participants’ incentives are high may expand cognitive benefits associated with tDCS. This finding is relevant for translational work using tDCS in clinical populations, in which motivation can be a concern. PMID:25462798

Construction of a solenoid used on a magnetized plasma experiment

DOE PAGES

Klein, S. R.; Manuel, M. J. -E.; Pollock, B. B.; ...

2014-10-30

Creating magnetized jets in the laboratory is relevant to studying young stellar objects, but generating these types of plasmas within the laboratory setting has proven to be challenging. Here, we present the construction of a solenoid designed to produce an axial magnetic field with strengths in the gap of up to 5 T. This novel design was a compact 75 mm × 63 mm × 88 mm, allowing it to be placed in the Titan target chamber. As a result, it was robust, surviving over 50 discharges producing fields ≲ 5 T, reaching a peak magnetic field of 12.5 T.

Obtaining sparse distributions in 2D inverse problems.

PubMed

Reci, A; Sederman, A J; Gladden, L F

2017-08-01

The mathematics of inverse problems has relevance across numerous estimation problems in science and engineering. L 1 regularization has attracted recent attention in reconstructing the system properties in the case of sparse inverse problems; i.e., when the true property sought is not adequately described by a continuous distribution, in particular in Compressed Sensing image reconstruction. In this work, we focus on the application of L 1 regularization to a class of inverse problems; relaxation-relaxation, T 1 -T 2 , and diffusion-relaxation, D-T 2 , correlation experiments in NMR, which have found widespread applications in a number of areas including probing surface interactions in catalysis and characterizing fluid composition and pore structures in rocks. We introduce a robust algorithm for solving the L 1 regularization problem and provide a guide to implementing it, including the choice of the amount of regularization used and the assignment of error estimates. We then show experimentally that L 1 regularization has significant advantages over both the Non-Negative Least Squares (NNLS) algorithm and Tikhonov regularization. It is shown that the L 1 regularization algorithm stably recovers a distribution at a signal to noise ratio<20 and that it resolves relaxation time constants and diffusion coefficients differing by as little as 10%. The enhanced resolving capability is used to measure the inter and intra particle concentrations of a mixture of hexane and dodecane present within porous silica beads immersed within a bulk liquid phase; neither NNLS nor Tikhonov regularization are able to provide this resolution. This experimental study shows that the approach enables discrimination between different chemical species when direct spectroscopic discrimination is impossible, and hence measurement of chemical composition within porous media, such as catalysts or rocks, is possible while still being stable to high levels of noise. Copyright © 2017. Published by Elsevier Inc.

Obtaining sparse distributions in 2D inverse problems

NASA Astrophysics Data System (ADS)

Reci, A.; Sederman, A. J.; Gladden, L. F.

2017-08-01

The mathematics of inverse problems has relevance across numerous estimation problems in science and engineering. L1 regularization has attracted recent attention in reconstructing the system properties in the case of sparse inverse problems; i.e., when the true property sought is not adequately described by a continuous distribution, in particular in Compressed Sensing image reconstruction. In this work, we focus on the application of L1 regularization to a class of inverse problems; relaxation-relaxation, T1-T2, and diffusion-relaxation, D-T2, correlation experiments in NMR, which have found widespread applications in a number of areas including probing surface interactions in catalysis and characterizing fluid composition and pore structures in rocks. We introduce a robust algorithm for solving the L1 regularization problem and provide a guide to implementing it, including the choice of the amount of regularization used and the assignment of error estimates. We then show experimentally that L1 regularization has significant advantages over both the Non-Negative Least Squares (NNLS) algorithm and Tikhonov regularization. It is shown that the L1 regularization algorithm stably recovers a distribution at a signal to noise ratio < 20 and that it resolves relaxation time constants and diffusion coefficients differing by as little as 10%. The enhanced resolving capability is used to measure the inter and intra particle concentrations of a mixture of hexane and dodecane present within porous silica beads immersed within a bulk liquid phase; neither NNLS nor Tikhonov regularization are able to provide this resolution. This experimental study shows that the approach enables discrimination between different chemical species when direct spectroscopic discrimination is impossible, and hence measurement of chemical composition within porous media, such as catalysts or rocks, is possible while still being stable to high levels of noise.

Expression of checkpoint molecules on myeloid-derived suppressor cells.

PubMed

Ballbach, Marlene; Dannert, Angelika; Singh, Anurag; Siegmund, Darina M; Handgretinger, Rupert; Piali, Luca; Rieber, Nikolaus; Hartl, Dominik

2017-12-01

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population expanded in cancer, infection and autoimmunity capable of suppressing T-cell functions. Checkpoint inhibitors have emerged as a key therapeutic strategy in immune-oncology. While checkpoint molecules were initially associated with T cell functions, recent evidence suggests a broader expression and function in innate myeloid cells. Previous studies provided first evidence for a potential role for checkpoints on MDSCs, yet the human relevance remained poorly understood. Therefore, we investigated the expression and functional relevance of checkpoint molecules in human MDSC-T-cell interactions. Our studies demonstrate that programmed death-ligand 1 (PD-L1) is expressed on granulocytic MDSCs upon co-culture with T cells. Transwell experiments showed that cell-to-cell contact was required for MDSC-T-cell interactions and antibody blocking studies showed that targeting PD-L1 partially impaired MDSC-mediated T-cell suppression. Collectively, these studies suggest a role for PD-L1 in human MDSC function and thereby expand the functionality of this checkpoint beyond T cells, which could pave the way for further understanding and therapeutic targeting of PD-1/PD-L1 in innate immune-mediated diseases. Copyright © 2017 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lichtscheidl, Alejandro G.; Janicke, Michael T.; Scott, Brian L.

The synthesis and full characterization, including Nuclear Magnetic Resonance (NMR) data ( 1H, 13C{ 1H} and 119Sn{ 1H}), for a series of Me 3SnX (X = O-2,6-tBu 2C 6H 3 (1), (Me 3Sn)N(2,6- iPr 2C 6H 3) (3), NH-2,4,6- tBu 3C 6H 2 (4), N(SiMe 3) 2 (5), NEt 2, C 5Me 5 (6), Cl, Br, I, and SnMe 3) compounds in benzene-d 6, toluene-d 8, dichloromethane-d 2, chloroform-d 1, acetonitrile-d 3, and tetrahydrofuran-d 8 are reported. The X-ray crystal structures of Me 3Sn(O-2,6- tBu 2C 6H 3) (1), Me 3Sn(O-2,6- iPr 2C 6H 3) (2), and (Me 3Sn)(NH-2,4,6- tBumore » 3C 6H 2) (4) are also presented. As a result, these compiled data complement existing literature data and ease the characterization of these compounds by routine NMR experiments.« less

Investigating the effect of a magnetic field on dose distributions at phantom-air interfaces using PRESAGE® 3D dosimeter and Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Costa, Filipa; Doran, Simon J.; Hanson, Ian M.; Nill, Simeon; Billas, Ilias; Shipley, David; Duane, Simon; Adamovics, John; Oelfke, Uwe

2018-03-01

Dosimetric quality assurance (QA) of the new Elekta Unity (MR-linac) will differ from the QA performed of a conventional linac due to the constant magnetic field, which creates an electron return effect (ERE). In this work we aim to validate PRESAGE® dosimetry in a transverse magnetic field, and assess its use to validate the research version of the Monaco TPS of the MR-linac. Cylindrical samples of PRESAGE® 3D dosimeter separated by an air gap were irradiated with a cobalt-60 unit, while placed between the poles of an electromagnet at 0.5 T and 1.5 T. This set-up was simulated in EGSnrc/Cavity Monte Carlo (MC) code and relative dose distributions were compared with measurements using 1D and 2D gamma criteria of 3% and 1.5 mm. The irradiation conditions were adapted for the MR-linac and compared with Monaco TPS simulations. Measured and EGSnrc/Cavity simulated profiles showed good agreement with a gamma passing rate of 99.9% for 0.5 T and 99.8% for 1.5 T. Measurements on the MR-linac also compared well with Monaco TPS simulations, with a gamma passing rate of 98.4% at 1.5 T. Results demonstrated that PRESAGE® can accurately measure dose and detect the ERE, encouraging its use as a QA tool to validate the Monaco TPS of the MR-linac for clinically relevant dose distributions at tissue-air boundaries.

Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.

PubMed

Heemstra, Karen A; Soeters, Maarten R; Fliers, Eric; Serlie, Mireille J; Burggraaf, Jacobus; van Doorn, Martijn B; van der Klaauw, Agatha A; Romijn, Johannes A; Smit, Johannes W; Corssmit, Eleonora P; Visser, Theo J

2009-06-01

The iodothyronine deiodinases D1, D2, and D3 enable tissue-specific adaptation of thyroid hormone levels in response to various conditions, such as hypothyroidism or fasting. The possible expression of D2 mRNA in skeletal muscle is intriguing because this enzyme could play a role in systemic as well as local T3 production. We determined D2 activity and D2 mRNA expression in human skeletal muscle biopsies under control conditions and during hypothyroidism, fasting, and hyperinsulinemia. This was a prospective study. The study was conducted at a university hospital. We studied 11 thyroidectomized patients with differentiated thyroid carcinoma (DTC) on and after 4 wk off T4( replacement and six healthy lean subjects in the fasting state and during hyperinsulinemia after both 14 and 62 h of fasting. D2 activity and D2 mRNA levels were measured in skeletal muscle samples. No differences were observed in muscle D2 mRNA levels in DTC patients on and off T4 replacement therapy. In healthy subjects, muscle D2 mRNA levels were lower after 62 h compared to 14 h of fasting. Insulin increased mRNA expression after 62 h, but not after 14 h of fasting. Skeletal muscle D2 activities were very low and not influenced by hypothyroidism and fasting. Human skeletal muscle D2 mRNA expression is modulated by fasting and insulin, but not by hypothyroidism. The lack of a clear effect of D2 mRNA modulation on the observed low D2 activities questions the physiological relevance of D2 activity in human skeletal muscle.

Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS

PubMed Central

Raju, Gajjela; Srinivas, Ragampeta; Santhosh Reddy, Vangala; Idris, Mohammed M.; Kamal, Ahmed; Nagesh, Narayana

2012-01-01

Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest. Electrospray ionization mass spectrometry (ESI-MS) and spectroscopic studies in solution were used to evaluate the interaction of PBD and TMPyP4 ligands, stoichiometry and selectivity to G-quadruplex DNA. Two synthetic ligands from PBD family, namely pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrid (PBD1), mixed imine-amide pyrrolobenzodiazepine dimer (PBD2) and 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4) were studied. G-rich single-stranded oligonucleotide d(5′GGGGTTGGGG3′) designated as d(T2G8), from the telomeric region of Tetrahymena Glaucoma, was considered for the interaction with ligands. ESI-MS and spectroscopic methods viz., circular dichroism (CD), UV-Visible, and fluorescence were employed to investigate the G-quadruplex structures formed by d(T2G8) sequence and its interaction with PBD and TMPyP4 ligands. From ESI-MS spectra, it is evident that the majority of quadruplexes exist as d(T2G8)2 and d(T2G8)4 forms possessing two to ten cations in the centre, thereby stabilizing the complex. CD band of PBD1 and PBD2 showed hypo and hyperchromicity, on interaction with quadruplex DNA, indicating unfolding and stabilization of quadruplex DNA complex, respectively. UV-Visible and fluorescence experiments suggest that PBD1 bind externally where as PBD2 intercalate moderately and bind externally to G-quadruplex DNA. Further, melting experiments using SYBR Green indicate that PBD1 unfolds and PBD2 stabilizes the G-quadruplex complex. ITC experiments using d(T2G8) quadruplex with PBD ligands reveal that PBD1 and PBD2 prefer external/loop binding and external/intercalative binding to quadruplex DNA, respectively. From experimental results it is clear that the interaction of PBD2 and TMPyP4 impart higher stability to the quadruplex complex. PMID:22558271

Tactical decisions for changeable cuttlefish camouflage: visual cues for choosing masquerade are relevant from a greater distance than visual cues used for background matching.

PubMed

Buresch, Kendra C; Ulmer, Kimberly M; Cramer, Corinne; McAnulty, Sarah; Davison, William; Mäthger, Lydia M; Hanlon, Roger T

2015-10-01

Cuttlefish use multiple camouflage tactics to evade their predators. Two common tactics are background matching (resembling the background to hinder detection) and masquerade (resembling an uninteresting or inanimate object to impede detection or recognition). We investigated how the distance and orientation of visual stimuli affected the choice of these two camouflage tactics. In the current experiments, cuttlefish were presented with three visual cues: 2D horizontal floor, 2D vertical wall, and 3D object. Each was placed at several distances: directly beneath (in a circle whose diameter was one body length (BL); at zero BL [(0BL); i.e., directly beside, but not beneath the cuttlefish]; at 1BL; and at 2BL. Cuttlefish continued to respond to 3D visual cues from a greater distance than to a horizontal or vertical stimulus. It appears that background matching is chosen when visual cues are relevant only in the immediate benthic surroundings. However, for masquerade, objects located multiple body lengths away remained relevant for choice of camouflage. © 2015 Marine Biological Laboratory.

Phase diagram and density of fluids in the water-methanol system: experiments and implications for the crystallization and dynamics of subsurface oceans in icy moons

NASA Astrophysics Data System (ADS)

Yao, C.; Mantegazzi, D.; Deschamps, F.; Sanchez-Valle, C.

2013-12-01

Methanol, CH3OH, has been recently observed in several comets and at the surface of Saturn's icy moon Enceladus, [Hodyss et al., 2009]. Its plausible presence in the subsurface ocean could significantly affect the thermal and structural evolution of the satellite [Deschamps et al., 2010]. Methanol lowers the melting temperature of water ice [Vuillard & Sanchez, 1961; Miller & Carpenter, 1964], hence decreasing the efficiency of convective heat transfer through the outer ice Ih shell, and affects the subsurface ocean density and thermo-chemical evolution. However, the phase diagram and the fluid density of the H2O - CH3OH system remains largely unknown at the high pressures and low temperature conditions relevant for the icy moon interiors. In this study, we determined experimentally the liquidus temperature of Ice Ih and Ice VI and the fluid density in the binary water-methanol system (5, 10 and 20 w% CH3OH) from sound velocity measurments by Brillouin scattering spectroscopy over the P-T range 230 - 300 K and 10-4 - 1.2 GPa. The experiments were conducted using a membrane-type diamond anvil cell (mDAC) and an in-house designed Peltier cooling system to achieve the low temperatures of interest. Melting and crystallization in the system was visually monitored and confirmed from changes in the Brillouin spectra and in the pressure dependence of the measured sound velocities. The density of fluids ρ(P, T,x) in the binary system weas determined from the inversion of sound velocities measured in the fluids as a function of pressure along isotherms from 230 to 300 K. The results are used to propose a thermodynamic model for the CH3OH-H2O system over the investigated P-T range and further used to examine the effect of the methanol on the crystallization and thermo-chemical evolution of the subsurface ocean. The implications of these results for the thermal and structural evolution of icy moons, with particular applications to Titan, will be further discussed. References : Deschamps, F., Mousis, O., Sanchez-Valle, C., and Lunine, J.I., Astrophys. J., 2010. Hodyss, R., Parkinson, C.D. Johnson, V.D., Stern, J.V., Goguen, J.D, Yung, Y.L., and Kanik, I., Geophys. Res. Lett., 1992. Miller, G.A., and Carpenter, D.A., J. Chem. Eng. Data, 1964. Vuillard, G., and Sanchez, M., Bull. Soc. Chim. France, 1961.

Lost in the supermarket: Quantifying the cost of partitioning memory sets in hybrid search.

PubMed

Boettcher, Sage E P; Drew, Trafton; Wolfe, Jeremy M

2018-01-01

The items on a memorized grocery list are not relevant in every aisle; for example, it is useless to search for the cabbage in the cereal aisle. It might be beneficial if one could mentally partition the list so only the relevant subset was active, so that vegetables would be activated in the produce section. In four experiments, we explored observers' abilities to partition memory searches. For example, if observers held 16 items in memory, but only eight of the items were relevant, would response times resemble a search through eight or 16 items? In Experiments 1a and 1b, observers were not faster for the partition set; however, they suffered relatively small deficits when "lures" (items from the irrelevant subset) were presented, indicating that they were aware of the partition. In Experiment 2 the partitions were based on semantic distinctions, and again, observers were unable to restrict search to the relevant items. In Experiments 3a and 3b, observers attempted to remove items from the list one trial at a time but did not speed up over the course of a block, indicating that they also could not limit their memory searches. Finally, Experiments 4a, 4b, 4c, and 4d showed that observers were able to limit their memory searches when a subset was relevant for a run of trials. Overall, observers appear to be unable or unwilling to partition memory sets from trial to trial, yet they are capable of restricting search to a memory subset that remains relevant for several trials. This pattern is consistent with a cost to switching between currently relevant memory items.

Predicting change over time in career planning and career exploration for high school students.

PubMed

Creed, Peter A; Patton, Wendy; Prideaux, Lee-Ann

2007-06-01

This study assessed 166 high school students in Grade 8 and again in Grade 10. Four models were tested: (a) whether the T1 predictor variables (career knowledge, indecision, decision-making self efficacy, self-esteem, demographics) predicted the outcome variable (career planning/exploration) at T1; (b) whether the T1 predictor variables predicted the outcome variable at T2; (c) whether the T1 predictor variables predicted change in the outcome variable from T1-T2; and (d) whether changes in the predictor variables from T1-T2 predicted change in the outcome variable from T1-T2. Strong associations (R(2)=34%) were identified for the T1 analysis (confidence, ability and paid work experience were positively associated with career planning/exploration). T1 variables were less useful predictors of career planning/exploration at T2 (R(2)=9%; having more confidence at T1 was associated with more career planning/exploration at T2) and change in career planning/exploration from T1-T2 (R(2)=11%; less confidence and no work experience were associated with change in career planning/exploration from T1-T2). When testing effect of changes in predictor variables predicting changes in outcome variable (R(2)=22%), three important predictors, indecision, work experience and confidence, were identified. Overall, results indicated important roles for self-efficacy and early work experiences in current and future career planning/exploration of high school students.

Performance of photomultiplier tubes and sodium iodide scintillation detector systems

NASA Technical Reports Server (NTRS)

Meegan, C. A.

1981-01-01

The performance of photomultiplier tubes (PMT's) and scintillation detector systems incorporating 50.8 by 1.27 cm NaI (T l) crystals was investigated to determine the characteristics of the photomultiplier tubes and optimize the detector geometry for the Burst and Transient Source Experiment on the Gamma Ray Observatory. Background information on performance characteristics of PMT's and NaI (T l) detectors is provided, procedures for measurement of relevant parameters are specified, and results of these measurements are presented.

Evaluation of free modeling targets in CASP11 and ROLL.

PubMed

Kinch, Lisa N; Li, Wenlin; Monastyrskyy, Bohdan; Kryshtafovych, Andriy; Grishin, Nick V

2016-09-01

We present an assessment of 'template-free modeling' (FM) in CASP11and ROLL. Community-wide server performance suggested the use of automated scores similar to previous CASPs would provide a good system of evaluating performance, even in the absence of comprehensive manual assessment. The CASP11 FM category included several outstanding examples, including successful prediction by the Baker group of a 256-residue target (T0806-D1) that lacked sequence similarity to any existing template. The top server model prediction by Zhang's Quark, which was apparently selected and refined by several manual groups, encompassed the entire fold of target T0837-D1. Methods from the same two groups tended to dominate overall CASP11 FM and ROLL rankings. Comparison of top FM predictions with those from the previous CASP experiment revealed progress in the category, particularly reflected in high prediction accuracy for larger protein domains. FM prediction models for two cases were sufficient to provide functional insights that were otherwise not obtainable by traditional sequence analysis methods. Importantly, CASP11 abstracts revealed that alignment-based contact prediction methods brought about much of the CASP11 progress, producing both of the functionally relevant models as well as several of the other outstanding structure predictions. These methodological advances enabled de novo modeling of much larger domain structures than was previously possible and allowed prediction of functional sites. Proteins 2016; 84(Suppl 1):51-66. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Review of Inertial Confinement Fusion

NASA Astrophysics Data System (ADS)

Haines, M. G.

The physics of inertial confinement fusion is reviewed. The trend to short-wavelength lasers is argued, and the distinction between direct and indirect (soft X-ray) drive is made. Key present issues include the non-linear growth of Rayleigh-Taylor (R-T) instabilities, the seeding of this instability by the initial laser imprint, the relevance of self-generated magnetic fields, and the importance of parametric instabilities (stimulated Brillouin and Raman scattering) in gas-filled hohlraums. Experiments are reviewed which explore the R-T instability in both planar and converging geometry. The employment of various optical smoothing techniques is contrasted with the overcoating of the capsule by gold coated plastic foams to reduce considerably the imprint problem. The role of spontaneously generated magnetic fields in non-symmetric plasmas is discussed. Recent hohlraum compression results are presented together with gas bag targets which replicate the long-scale-length low density plasmas expected in NIF gas filled hohlraums. The onset of first Brillouin and then Raman scattering is observed. The fast ignitor scheme is a proposal to use an intense short pulse laser to drill a hole through the coronal plasma and then, with laser excited fast electrons, create a propagating thermonuclear spark in a dense, relatively cold laser-compressed target. Some preliminary results of laser hole drilling and 2-D and 3-D PIC simulations of this and the > 10^8 Gauss self-generated magnetic fields are presented. The proposed National Ignition Facility (NIF) is described.

[Handover between home and respite care facilities : Delphi survey within the context of continuity of care for people with dementia].

PubMed

Kuske, S; Roes, M; Bartholomeyczik, S

2016-07-01

Criteria for the handover between healthcare settings were identified based on a review and on results of empirical data. This study was carried out to select the most relevant criteria for defining the quality of continuity of care of people with dementia (PwD) in the context of the handover between care at home and respite care facilities. A modified classical two-step Delphi design was used in combination with a group Delphi design. A total of 28 core criteria with a consensus strength of > 60 % are presented. Safety-relevant information, especially the personal habits of PwD and the role of informal caregivers in the handover between care settings are important. Furthermore, the following general principles to ensure the quality of continuity of the care of PwD were deduced: completeness, verification, multipath communication, timeliness and topicality, accessibility and defined responsibilities, roles and standardization. A successful transition of PwD to respite care facilities relies on the provision of relevant information, considering personal habits, before the day of transition. Furthermore, a timely preparation for discharge is important. The individual needs of the informal caregivers with regard to their support should be considered. Professionals who are responsible in handover processes should have solid communication competence in order to collect relevant information from informal caregivers, who have a strong individual care experience with the PwD.

Loudness enhancement - Monaural, binaural, and dichotic

NASA Technical Reports Server (NTRS)

Elmasian, R.; Galambos, R.

1975-01-01

When one tone burst (T) precedes another (S) by 100 msec, variations in the intensity of T systematically influence the loudness of S. When T is more intense than S, S is increased; and when T is less intense, S loudness is decreased. This occurs in monaural, binaural, and dichotic paradigms of signal presentation. When T and S are presented to the same ear (monaural or binaural), there is more enhancement with less intersubject variability than when they are presented to different ears (dichotic paradigm). Monaural enhancements as large as 30 dB can readily be demonstrated, but decrements rarely exceed 5 dB. Possible physiological mechanisms are discussed for this loudness enhancement, which apparently shares certain characteristics with time-order error, assimilation, and temporal partial masking experiments.

Susceptibility-based functional brain mapping by 3D deconvolution of an MR-phase activation map.

PubMed

Chen, Zikuan; Liu, Jingyu; Calhoun, Vince D

2013-05-30

The underlying source of T2*-weighted magnetic resonance imaging (T2*MRI) for brain imaging is magnetic susceptibility (denoted by χ). T2*MRI outputs a complex-valued MR image consisting of magnitude and phase information. Recent research has shown that both the magnitude and the phase images are morphologically different from the source χ, primarily due to 3D convolution, and that the source χ can be reconstructed from complex MR images by computed inverse MRI (CIMRI). Thus, we can obtain a 4D χ dataset from a complex 4D MR dataset acquired from a brain functional MRI study by repeating CIMRI to reconstruct 3D χ volumes at each timepoint. Because the reconstructed χ is a more direct representation of neuronal activity than the MR image, we propose a method for χ-based functional brain mapping, which is numerically characterised by a temporal correlation map of χ responses to a stimulant task. Under the linear imaging conditions used for T2*MRI, we show that the χ activation map can be calculated from the MR phase map by CIMRI. We validate our approach using numerical simulations and Gd-phantom experiments. We also analyse real data from a finger-tapping visuomotor experiment and show that the χ-based functional mapping provides additional activation details (in the form of positive and negative correlation patterns) beyond those generated by conventional MR-magnitude-based mapping. Copyright © 2013 Elsevier B.V. All rights reserved.

Effects of RF profile on precision of quantitative T2 mapping using dual-echo steady-state acquisition.

PubMed

Wu, Pei-Hsin; Cheng, Cheng-Chieh; Wu, Ming-Long; Chao, Tzu-Cheng; Chung, Hsiao-Wen; Huang, Teng-Yi

2014-01-01

The dual echo steady-state (DESS) sequence has been shown successful in achieving fast T2 mapping with good precision. Under-estimation of T2, however, becomes increasingly prominent as the flip angle decreases. In 3D DESS imaging, therefore, the derived T2 values would become a function of the slice location in the presence of non-ideal slice profile of the excitation RF pulse. Furthermore, the pattern of slice-dependent variation in T2 estimates is dependent on the RF pulse waveform. Multi-slice 2D DESS imaging provides better inter-slice consistency, but the signal intensity is subject to integrated effects of within-slice distribution of the actual flip angle. Consequently, T2 measured using 2D DESS is prone to inaccuracy even at the designated flip angle of 90°. In this study, both phantom and human experiments demonstrate the above phenomena in good agreement with model prediction. © 2013.

Origin of intrinsic Josephson coupling in the cuprates and its relation to order parameter symmetry: An incoherent hopping model

NASA Astrophysics Data System (ADS)

Radtke, R. J.; Levin, K.

1995-02-01

Experiments on the cuprate superconductors demonstrate that these materials may be viewed as a stack of Josephson junctions along the direction normal to the CuO 2 planes (the c-axis). In this paper, we present a model which describes this intrinsic Josephson coupling in terms of incherent quasiparticle hopping along the c-axis arising from wave-function overlap, impurity-assisted hopping, and boson-assised hopping. We use this model to compute the magnitude and temperature T dependence of the resulting Josephson critical current jc( T) for s- and d-wave superconductors. Contrary to other approaches, d-wave pairing in this model is compatible with an intrinsic Josephson effect at all hole concentrations and leads to jc( T) αT at low T. By parameterizing our theory with c-axis resistivity data from YBa 2Cu 3O 7-δ (YBCO), we estimate jc( T) for optimally doped and underdoped members of this family. jc( T) can be measured either directly or indirectly through microwave penetration depth experiments, and current measurements on Bi 2Sr 2CaCu 2O 8 and La 2- xSr xCuO 4 are found to be consistent with s-wave pairing and the dominance of assisted hopping processes. The situation in YBCO is still unclear, but our estimates suggest that further experiments on this compound would be of great help in elucidating the validity of our model in general and the pairing symmetry in particular.

DESIGN OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANDERER,P.; ET AL.

2003-06-15

Superconducting combined function magnets will be utilized for the 50GeV-750kW proton beam line for the J-PARC neutrino experiment and an R and D program has been launched at KEK. The magnet is designed to provide a combined function with a dipole field of 2.59 T and a quadrupole field of 18.7 T/m in a coil aperture of 173.4 mm. A single layer coil is proposed to reduce the fabrication cost and the coil arrangement in the 2-D cross-section results in left-right asymmetry. This paper reports the design study of the magnet.

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism.

PubMed

Hernández-Alvarez, María Isabel; Díaz-Ramos, Angels; Berdasco, María; Cobb, Jeff; Planet, Evarist; Cooper, Diane; Pazderska, Agnieszka; Wanic, Krzystof; O'Hanlon, Declan; Gomez, Antonio; de la Ballina, Laura R; Esteller, Manel; Palacin, Manuel; O'Gorman, Donal J; Nolan, John J; Zorzano, Antonio

2017-10-23

The molecular mechanisms responsible for the pathophysiological traits of type 2 diabetes are incompletely understood. Here we have performed transcriptomic analysis in skeletal muscle, and plasma metabolomics from subjects with classical and early-onset forms of type 2 diabetes (T2D). Focused studies were also performed in tissues from ob/ob and db/db mice. We document that T2D, both early and late onset, are characterized by reduced muscle expression of genes involved in branched-chain amino acids (BCAA) metabolism. Weighted Co-expression Networks Analysis provided support to idea that the BCAA genes are relevant in the pathophysiology of type 2 diabetes, and that mitochondrial BCAA management is impaired in skeletal muscle from T2D patients. In diabetic mice model we detected alterations in skeletal muscle proteins involved in BCAA metabolism but not in obese mice. Metabolomic analysis revealed increased levels of branched-chain keto acids (BCKA), and BCAA in plasma of T2D patients, which may result from the disruption of muscle BCAA management. Our data support the view that inhibition of genes involved in BCAA handling in skeletal muscle takes place as part of the pathophysiology of type 2 diabetes, and this occurs both in early-onset and in classical type 2 diabetes.

A kinesthetic-tactual display concept for helicopter-pilot workload reduction

NASA Technical Reports Server (NTRS)

Gilson, R. D.; Dunn, R. S.; Sun, P.

1977-01-01

A kinesthetic-tactual (K-T) display concept is now under research and development (R & D) at the Ohio State University. It appears to offer considerable promise for useful application in helicopters by conveying control information via the sense of touch. This is a review of the overall R & D program including the original K-T display design, initial studies in automobile and fixed-wing vehicles, and feasibility experiments in a helicopter simulator. In addition to investigations of control and potential workload reduction, present efforts are directed toward establishing optimal design requirements for K-T helicopter displays. Potential applications, modes of usage, and the kinds of information that may be displayed in helicopter applications are discussed along with a brief forecast of future R & D. A brief description of the latest multi-axis laboratory prototype K-T display is also provided.

Suppression of high pT hadrons in Pb + Pb collisions at \\sqrt{s} = 2.76 TeV

NASA Astrophysics Data System (ADS)

Zhang, Hanzhong; Chen, Xiao-Fang; Hirano, Tetsufumi; Wang, Enke; Wang, Xin-Nian

2011-12-01

The nuclear modification factor RAA(pT) for large pT hadrons in central Pb + Pb collisions at \\sqrt{s}=2.76 TeV/n is calculated within the next-to-leading order perturbative QCD parton model with medium-modified fragmentation functions and agree well with the new data. The jet transport parameter that controls medium modification is assumed to be proportional to the initial parton density and the coefficient is fixed by the RHIC data. The charged hadron multiplicity dNch/dη = 1584 ± 80 in central Pb + Pb collisions from the ALICE experiment at the LHC is used to determine both the jet transport parameter and the initial condition for (3+1)D ideal hydrodynamic evolution of the bulk matter that is employed for the calculation of RAA(pT).

The Effects of L2 Experience and Vowel Context on the Perceptual Assimilation of English Fricatives by L2 Thai Learners

ERIC Educational Resources Information Center

Kitikanan, Patchanok

2017-01-01

The aim of this study is to investigate the effect of vowel context and language experience in the perceived similarity between L2 English fricatives and Thai sounds. The target English sounds being investigated were the sounds /v, f, w, ?, t?, s, ð, d, z, ?, t??/. These sounds were elicited from four native English speakers in words in onset…

Determination of linear viscoelastic properties of an entangled polymer melt by probe rheology simulations

NASA Astrophysics Data System (ADS)

Karim, Mir; Indei, Tsutomu; Schieber, Jay D.; Khare, Rajesh

2016-01-01

Particle rheology is used to extract the linear viscoelastic properties of an entangled polymer melt from molecular dynamics simulations. The motion of a stiff, approximately spherical particle is tracked in both passive and active modes. We demonstrate that the dynamic modulus of the melt can be extracted under certain limitations using this technique. As shown before for unentangled chains [Karim et al., Phys. Rev. E 86, 051501 (2012), 10.1103/PhysRevE.86.051501], the frequency range of applicability is substantially expanded when both particle and medium inertia are properly accounted for by using our inertial version of the generalized Stokes-Einstein relation (IGSER). The system used here introduces an entanglement length dT, in addition to those length scales already relevant: monomer bead size d , probe size R , polymer radius of gyration Rg, simulation box size L , shear wave penetration length Δ , and wave period Λ . Previously, we demonstrated a number of restrictions necessary to obtain the relevant fluid properties: continuum approximation breaks down when d ≳Λ ; medium inertia is important and IGSER is required when R ≳Λ ; and the probe should not experience hydrodynamic interaction with its periodic images, L ≳Δ . These restrictions are also observed here. A simple scaling argument for entangled polymers shows that the simulation box size must scale with polymer molecular weight as Mw3. Continuum analysis requires the existence of an added mass to the probe particle from the entrained medium but was not observed in the earlier work for unentangled chains. We confirm here that this added mass is necessary only when the thickness LS of the shell around the particle that contains the added mass, LS>d . We also demonstrate that the IGSER can be used to predict particle displacement over a given timescale from knowledge of medium viscoelasticity; such ability will be of interest for designing nanoparticle-based drug delivery.

Statics and dynamics of adhesion between two soap bubbles.

PubMed

Besson, S; Debrégeas, G

2007-10-01

An original set-up is used to study the adhesive properties of two hemispherical soap bubbles put into contact. The contact angle at the line connecting the three films is extracted by image analysis of the bubbles profiles. After the initial contact, the angle rapidly reaches a static value slightly larger than the standard 120 degrees angle expected from Plateau rule. This deviation is consistent with previous experimental and theoretical studies: it can be quantitatively predicted by taking into account the finite size of the Plateau border (the liquid volume trapped at the vertex) in the free energy minimization. The visco-elastic adhesion properties of the bubbles are further explored by measuring the deviation Delta theta (d)(t) of the contact angle from the static value as the distance between the two bubbles supports is sinusoidally modulated. It is found to linearly increase with Delta r(c) / r(c) , where r(c) is the radius of the central film and Delta r(c) the amplitude of modulation of this length induced by the displacement of the supports. The in-phase and out-of-phase components of Delta theta (d)(t) with the imposed modulation frequency are systematically probed, which reveals a transition from a viscous to an elastic response of the system with a crossover pulsation of the order 1rad x s(-1). Independent interfacial rheological measurements, obtained from an oscillating bubble experiment, allow us to develop a model of dynamic adhesion which is confronted to our experimental results. The relevance of such adhesive dynamic properties to the rheology of foams is briefly discussed using a perturbative approach to the Princen 2D model of foams.

Spin-isospin excitations from the ground-state of 64Ni

NASA Astrophysics Data System (ADS)

Popescu, L.; Adachi, T.; Bäumer, C.; Berg, G. P. A.; van den Berg, A. M.; von Brentano, P.; Frekers, D.; de Frenne, D.; Fujita, K.; Fujita, Y.; Grewe, E. W.; Haefner, P.; Hatanaka, K.; Hunyadi, M.; de Huu, M.; Jacobs, E.; Johansson, H.; Korff, A.; Negret, A.; Nakanishi, K.; von Neumann-Cosel, P.; Rakers, S.; Ryezayeva, N.; Sakemi, Y.; Shevchenko, A.; Shimbara, Y.; Shimizu, Y.; Simon, H.; Tameshige, Y.; Tamii, A.; Uchida, M.; Wörtche, H. J.; Yosoi, M.

2006-03-01

Spin-isospin (Gamow-Teller) excitations in 64Cu and 64Co have been studied using (3He,t) and (d,2He) charge-exchange reactions on 64Ni. As the isospin of the 64Ni ground-state is T0=4, states with T=3, 4 and 5 in 64Cu are excited via the (3He,t) reaction and states with T=5 in 64Co via (d,2He). If we assume that the nuclear interaction is charge symmetric, the T=5 states in 64Cu should appear at corresponding excitation energies (if corrected for the Coulomb displacement) and with similar strengths as the T=5 states in 64Co. As in the 64Cu spectrum the T=5 states are very weakly excited, only by combining the results of the two complementary experiments one can estimate the Gamow-Teller strength starting from 64Ni in a consistent way.

Spin-isospin excitations from the ground-state of 64Ni

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popescu, L.; Frenne, D. de; Jacobs, E.

2006-03-13

Spin-isospin (Gamow-Teller) excitations in 64Cu and 64Co have been studied using (3He,t) and (d,2He) charge-exchange reactions on 64Ni. As the isospin of the 64Ni ground-state is T0=4, states with T=3, 4 and 5 in 64Cu are excited via the (3He,t) reaction and states with T=5 in 64Co via (d,2He). If we assume that the nuclear interaction is charge symmetric, the T=5 states in 64Cu should appear at corresponding excitation energies (if corrected for the Coulomb displacement) and with similar strengths as the T=5 states in 64Co. As in the 64Cu spectrum the T=5 states are very weakly excited, only bymore » combining the results of the two complementary experiments one can estimate the Gamow-Teller strength starting from 64Ni in a consistent way.« less

Proceedings of the Conference on the Design of Experiments in Army Research Development and Testing (20th). Held at Army Operational Test and Evaluation Agency and Army Engineer Center at Fort Belvoir, VA., on 23-25 October 1974. Part 1

DTIC Science & Technology

1975-06-01

Anton Hauschild, Manufactur ing Technology D i r e c t o r a t e , Frankford Arsonal , P h i l a d e l p h i a , Pennsy lvania RATE DEPENDENT...Bethesda, Mary land OBSERVAT I ONS ON THE ALGEBRA OF NON-N0R;IAL FUNCT 1 ONS Donald M, Neal, Mechanics Research Laboratory, A r m y M a t e r i a l...a r a c t e r i s t i c func t ions i n combination wi th elementary m a t r i x a l g e b r a , he demonstrated t h e independence of I I v

Stability of the Mézard-Parisi Solution for Random Manifolds

NASA Astrophysics Data System (ADS)

Carlucci, D. M.; de Dominicis, C.; Temesvari, T.

1996-08-01

The eigenvalues of the Hessian associated with random manifolds are constructed for the general case of R steps of replica symmetry breaking. For the Parisi limit Rrightarrow infty (continuum replica symmetry breaking) which is relevant for the manifold dimension D<2, they are shown to be non negative. Les valeurs propres de la hessienne, associée avec une variété aléatoire, sont construites dans le cas général de R étapes de brisure de la symétrie des répliques. Dans la limite de Parisi, Rrightarrow infty (brisure continue de la symétrie des répliques) qui est pertinente pour la dimension de la variété D<2, on montre qu'elles sont non négatives.

Blur-resistant perimetric stimuli.

PubMed

Horner, Douglas G; Dul, Mitchell W; Swanson, William H; Liu, Tiffany; Tran, Irene

2013-05-01

To develop perimetric stimuli that are resistant to the effects of peripheral defocus. One eye each was tested on subjects free of eye disease. Experiment 1 assessed spatial frequency, testing 12 subjects at eccentricities from 2 to 7 degrees using blur levels from 0 to 3 diopters (D) for two (Gabor) stimuli (spatial SD, 0.5 degrees; spatial frequencies, 0.5 and 1.0 cycles per degree [cpd]). Experiment 2 assessed stimulus size, testing 12 subjects at eccentricities from 4 to 7 degrees using blur levels 0 to 6 D for two Gaussians with SD of 0.5 and 0.25 degrees and a 0.5-cpd Gabor with SD of 0.5 degrees. Experiment 3 tested 13 subjects at eccentricities from fixation to 27 degrees using blur levels 0 to 6 D for Gabor stimuli at 56 locations; the spatial frequency ranged from 0.14 to 0.50 cpd with location, and SD was scaled accordingly. In experiment 1, blur by 3 D caused a small decline in log contrast sensitivity for the 0.5-cpd stimulus (mean ± SE, 0.09 ± 0.08 log units) and a larger (t = 7.7, p < 0.0001) decline for the 1.0-cpd stimulus (0.37 ± 0.13 log units). In experiment 2, blur by 6 D caused minimal decline for the larger Gaussian, by 0.17 ± 0.16 log units, and larger (t > 4.5, p < 0.001) declines for the smaller Gaussian (0.33 ± 0.16 log units) and the Gabor (0.36 ± 0.18 log units). In experiment 3, blur by 6 D caused declines by 0.27 ± 0.05 log units for eccentricities from 0 to 10 degrees, by 0.20 ± 0.04 log units for eccentricities from 10 to 20 degrees, and 0.13 ± 0.03 log units for eccentricities from 20 to 27 degrees. Experiments 1 and 2 allowed us to design stimuli for experiment 3 that were resistant to effects of peripheral defocus.

[The "Académie nationale de Médecine" and the "Société française d'Histoire de la Médecine"].

PubMed

Lefebvre, Pierre

2003-01-01

The "Académie nationale de Médecine" was created in 1902 in Paris in the same time as the "Société française d'Histoire de la Médecine" but the relationship between the two societies depended upon the characters rather than the institutions. Thus two recent common experiences of the recent past urged to strengthen their links.

Scaling properties of fractional momentum loss of high- p T hadrons in nucleus-nucleus collisions at s N N from 62.4 GeV to 2.76 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adare, A.; Afanasiev, S.; Aidala, C.

2016-02-22

We present measurements of the fractional momentum loss (S loss = delta pT / pT) of high-transverse-momentum-identified hadrons in heavy-ion collisions. Using pi 0 in Au + Au and Cu + Cu collisions at √s NN = 62.4 and 200 GeV measured by the PHENIX experiment at the Relativistic Heavy Ion Collider and and charged hadrons in Pb + Pb collisions measured by the ALICE experiment at the Large Hadron Collider, we studied the scaling properties of S loss as a function of a number of variables: the number of participants, N part, the number of quark participants, N qp,more » the charged-particle density, dN ch/d η, and the Bjorken energy density times the equilibration time, epsilon Bjτ 0. We also find that the p T, where S loss has its maximum, varies both with centrality and collision energy. Above the maximum, S loss tends to follow a power-law function with all four scaling variables. Finally, the data at √s NN = 200 GeV and 2.76 TeV, for sufficiently high particle densities, have a common scaling of S loss with dN ch/d η and ε Bjτ 0, lending insight into the physics of parton energy loss.« less

Comparison of 2D simulations of detached divertor plasmas with divertor Thomson measurements in the DIII-D tokamak

DOE PAGES

Rognlien, Thomas D.; McLean, Adam G.; Fenstermacher, Max E.; ...

2017-01-27

A modeling study is reported using new 2D data from DIII-D tokamak divertor plasmas and improved 2D transport model that includes large cross-field drifts for the numerically difficult H-mode regime. The data set, which spans a range of plasmas densities for both forward and reverse toroidal magnetic field (B t) over a range of plasma densities, is provided by divertor Thomson scattering (DTS). Measurements utilizing X-point sweeping give corresponding 2D profiles of electron temperature (T e) and density (n e) across both divertor legs for individual discharges. The calculations show the same features of in/out plasma asymmetries as measured inmore » the experiment, with the normal B t direction (ion ∇B drift toward the X-point) having higher n e and lower T e in the inner divertor leg than outer. Corresponding emission data for total radiated power shows a strong inner-divertor/outer-divertor asymmetry that is reproduced by the simulations. Furthermore, these 2D UEDGE transport simulations are enabled for steep-gradient H-mode conditions by newly implemented algorithms to control isolated grid-scale irregularities.« less

Activation of both acfA and acfD transcription by Vibrio cholerae ToxT requires binding to two centrally located DNA sites in an inverted repeat conformation.

PubMed

Withey, Jeffrey H; DiRita, Victor J

2005-05-01

The Gram-negative bacterium Vibrio cholerae is the infectious agent responsible for the disease Asiatic cholera. The genes required for V. cholerae virulence, such as those encoding the cholera toxin (CT) and toxin-coregulated pilus (TCP), are controlled by a cascade of transcriptional activators. Ultimately, the direct transcriptional activator of the majority of V. cholerae virulence genes is the AraC/XylS family member ToxT protein, the expression of which is activated by the ToxR and TcpP proteins. Previous studies have identified the DNA sites to which ToxT binds upstream of the ctx operon, encoding CT, and the tcpA operon, encoding, among other products, the major subunit of the TCP. These known ToxT binding sites are seemingly dissimilar in sequence other than being A/T rich. Further results suggested that ctx and tcpA each has a pair of ToxT binding sites arranged in a direct repeat orientation upstream of the core promoter elements. In this work, using both transcriptional lacZ fusions and in vitro copper-phenanthroline footprinting experiments, we have identified the ToxT binding sites between the divergently transcribed acfA and acfD genes, which encode components of the accessory colonization factor required for efficient intestinal colonization by V. cholerae. Our results indicate that ToxT binds to a pair of DNA sites between acfA and acfD in an inverted repeat orientation. Moreover, a mutational analysis of the ToxT binding sites indicates that both binding sites are required by ToxT for transcriptional activation of both acfA and acfD. Using copper-phenanthroline footprinting to assess the occupancy of ToxT on DNA having mutations in one of these binding sites, we found that protection by ToxT of the unaltered binding site was not affected, whereas protection by ToxT of the mutant binding site was significantly reduced in the region of the mutations. The results of further footprinting experiments using DNA templates having +5 bp and +10 bp insertions between the two ToxT binding sites indicate that both binding sites are occupied by ToxT regardless of their positions relative to each other. Based on these results, we propose that ToxT binds independently to two DNA sites between acfA and acfD to activate transcription of both genes.

Comparative Inter-Species Pharmacokinetics of Phenoxyacetic Acid Herbicides and Related Organic Acids. Evidence that the Dog is Not a Relevant Species for Evaluation of Human Health Risk.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Timchalk, Chuck

Phenoxyacetic acids including 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxyacetic acid (MCPA) are widely utilized organic acid herbicides that have undergone extensive toxicity and pharmacokinetic analyses. The dog is particularly susceptible to the toxicity of phenoxyacetic acids and related organic acids relative to other species. Active renal clearance mechanisms for organic acids are ubiquitous in mammalian species, and thus a likely mechanism responsible for the increased sensitivity of the dog to these agents is linked to a lower capacity to secrete organic acids from the kidney. Using published data describing the pharmacokinetics of phenoxyacetic and structurally related organic acids in a varietymore » of species including humans, inter-species comparative pharmacokinetics were evaluated using allometic parameter scaling. For both 2,4-D and MCPA the dog plasma half-life (t1/2) and renal clearance (Clr; ml hr-1) rates did not scale as a function of body weight across species; whereas for all other species evaluated, including humans, these pharmacokinetic parameters reasonably scaled. This exceptional response in the dog is clearly illustrated by comparing the plasma t1/2 at comparable doses of 2,4-D and MCPA, across several species. At a dosage of 5 mg/kg, in dogs the plasma t1/2 for 2,4-D and MCPA were {approx}92 - 106 hr and 63 hr, respectively, which is substantially longer than in the rat ({approx}1 and 6 hr, respectively) or in humans (12 and 11 hr, respectively). This longer t1/2, and slower elimination in the dog, results in substantially higher body burdens of these organic acids, at comparable doses, relative to other species. Although these results indicate the important role of renal transport clearance mechanisms as determinants of the clearance and potential toxicity outcomes of phenoxyacetic acid herbicides across several species, other contributing mechanisms such as reabsorption from the renal tubules is highly likely. These findings suggest that for new structurally similar organic acids, a limited comparative species (rat vs. dog) pharmacokinetic analysis early in the toxicology evaluation process may provide important insight into the relevance of the dog. In summary, the substantial difference between the pharmacokinetics of phenoxyacetic acids and related organic acids in dogs relative to other species, including humans, questions the relevance of using dog toxicity data for the extrapolation of human health risk.« less

Surface Wind Field Analyses of Tropical Cyclones During TCS-08: Relative Impacts of Aircraft and Remotely-Sensed Observations

DTIC Science & Technology

2009-09-01

Campaign (T- PARC ). Rare aircraft measurements in the western North Pacific are utilized to define surface wind distributions of TY Nuri, TY Sinlaku...The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T- PARC ). Rare aircraft measurements in the...3 C. TCS08/T- PARC ................................................................................................... 4 D

Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats.

PubMed

Pandey, Shruti; Garabadu, Debapriya

2017-07-01

Piracetam exhibits anti-amnesic activity in several animal models of dementia. However, its anti-amnesic potential has yet to be evaluated in type-2 diabetes mellitus (T2DM)-induced encephalopathy. Therefore, in the present study, piracetam (25, 50 and 100 mg/kg) was screened for anti-amnesic and anti-diabetic activity in T2DM-induced encephalopathic male rats. Subsequently, anti-amnesic and anti-diabetic activities were evaluated for piracetam, metformin and their combination in T2DM-induced encephalopathic animals. Rats received streptozotocin (45 mg/kg) and nicotinamide (110 mg/kg) injections on day-1 (D-1) of the experimental schedule and were kept undisturbed for 35 days to exhibit T2DM-induced encephalopathy. All drug treatments were continued from D-7 to D-35 in both experiments. Piracetam (100 mg/kg) attenuated loss in learning and memory in terms of increase in escape latency on D-4 (D-34) and decrease in time spent in the target quadrant on D-5 (D-35) of Morris water maze test protocol, and spatial memory in terms of reduced spontaneous alternation behavior in Y-maze test of encephalopathic rats. Additionally, piracetam attenuated altered levels of fasting plasma glucose and insulin, HOMA-IR and HOMA-B in encephalopathic animals, comparatively lesser than metformin. In the next experiment, combination of piracetam and metformin exhibited better anti-amnesic but not anti-diabetic activity than respective monotherapies in encephalopathic rats. Further, the combination attenuated reduced acetylcholine level and increased acetylcholinesterase activity, increased glycogen synthase kinase-3β level and decreased brain-derived neurotropic factor level in hippocampus and pre-frontal cortex of encephalopathic animals. Thus, piracetam could be used as an adjuvant to metformin in the management of dementia in T2DM-induced encephalopathy.

Towards a programme of testing and qualification for structural and plasma-facing materials in ‘fusion neutron’ environments

NASA Astrophysics Data System (ADS)

Stork, D.; Heidinger, R.; Muroga, T.; Zinkle, S. J.; Moeslang, A.; Porton, M.; Boutard, J.-L.; Gonzalez, S.; Ibarra, A.

2017-09-01

Materials damage by 14.1MeV neutrons from deuterium-tritium (D-T) fusion reactions can only be characterised definitively by subjecting a relevant configuration of test materials to high-intensity ‘fusion-neutron spectrum sources’, i.e. those simulating closely D-T fusion-neutron spectra. This provides major challenges to programmes to design and construct a demonstration fusion reactor prior to having a large-scale, high-intensity source of such neutrons. In this paper, we discuss the different aspects related to these ‘relevant configuration’ tests, including: • generic issues in materials qualification/validation, comparing safety requirements against those of investment protection; • lessons learned from the fission programme, enabling a reduced fusion materials testing programme; • the use and limitations of presently available possible irradiation sources to optimise a fusion neutron testing program including fission-neutron irradiation of isotopically and chemically tailored steels, ion damage by high-energy helium ions and self-ion beams, or irradiation studies with neutron sources of non-fusion spectra; and • the different potential sources of simulated fusion neutron spectra and the choice using stripping reactions from deuterium-beam ions incident on light-element targets.

Preliminary investigation of single-file diffusion in complex plasma rings

NASA Astrophysics Data System (ADS)

Theisen, W. L.; Sheridan, T. E.

2010-04-01

Particles in one-dimensional (1D) systems cannot pass each other. However, it is still possible to define a diffusion process where the mean-squared displacement (msd) of an ensemble of particles in a 1D chain increases with time t. This process is called single-file diffusion. In contrast to diffusive processes that follow Fick's law, msdt, single-file diffusion is sub-Fickean and the msd is predicted to increase as t^1/2. We have recently created 1D dusty (complex) plasma rings in the DONUT (Dusty ONU experimenT) apparatus. Particle position data from these rings will be analyzed to determine the scaling of the msd with time and results will be compared with predictions of single-file diffusion theory.

Atomic parity violation as a probe of new physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marciano, W.J.; Rosner, J.L.

Effects of physics beyond the standard model on electroweak observables ares studied using the Peskin-Takeuchi isospin-conserving, {ital S}, and -breaking, {ital T}, parametrization of new'' quantum loop corrections. Experimental constraints on {ital S} and {ital T} are presented. Atomic parity-violating experiments are shown to be particularly sensitive to {ital S} with existing data giving {ital S}={minus}2.7{plus minus}2.0{plus minus}1.1. That constraint has important implications for generic technicolor models which predict {ital S}{approx equal}0.1{ital N}{sub {ital T}}{ital N}{sub {ital D}} ({ital N}{sub {ital T}} is the number of technicolors, {ital N}{sub {ital D}} is the number of technidoublets).

Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells.

PubMed

Ventre, Erwan; Brinza, Lilia; Schicklin, Stephane; Mafille, Julien; Coupet, Charles-Antoine; Marçais, Antoine; Djebali, Sophia; Jubin, Virginie; Walzer, Thierry; Marvel, Jacqueline

2012-10-01

IL-4 is one of the main cytokines produced during Th2-inducing pathologies. This cytokine has been shown to affect a number of immune processes such as Th differentiation and innate immune responses. However, the impact of IL-4 on CD8 T cell responses remains unclear. In this study, we analyzed the effects of IL-4 on global gene expression profiles of Ag-induced memory CD8 T cells in the mouse. Gene ontology analysis of this signature revealed that IL-4 regulated most importantly genes associated with immune responses. Moreover, this IL-4 signature overlapped with the set of genes preferentially expressed by memory CD8 T cells over naive CD8 T cells. In particular, IL-4 downregulated in vitro and in vivo in a STAT6-dependent manner the memory-specific expression of NKG2D, thereby increasing the activation threshold of memory CD8 T cells. Furthermore, IL-4 impaired activation of memory cells as well as their differentiation into effector cells. This phenomenon could have an important clinical relevance as patients affected by Th2 pathologies such as parasitic infections or atopic dermatitis often suffer from viral-induced complications possibly linked to inefficient CD8 T cell responses.

Secular trends of body mass index in North Indian children with Type 1 diabetes do not support the Accelerator Hypothesis.

PubMed

Dayal, Devi; Samprathi, Madhusudan; Jayaraman, Dhaarani; Kohat, Dilesh; Bhalla, Anil Kumar

2016-03-01

The accelerator hypothesis, which proposes a link between Type 1 diabetes (T1D) and Type 2 diabetes (T2D) through weight-related insulin resistance, remains untested in developing countries with increasing rates of childhood obesity and T1D, and different ethnicities. We aimed to test the accelerator hypothesis in the context of a significant increase in T1D at our centre. Medical records of children diagnosed with T1D between January 2005 and December 2014 were retrospectively reviewed. The body mass index (BMI) standard deviation scores (SDSs) were calculated using height and weight measurements recorded 1-2 months after diagnosis of T1D and compared with age-matched anthropometric data. The rate of change in BMI SDSs over time was calculated. Analysis of BMI data was undertaken for the three age categories: <5, 5 to <10 and >10 years. The mean age at diagnosis of 467 children with T1D was 7·27 ± 0·32 years and showed no change over the study period. There was a yearly increase of 14·11% in patient numbers; this increase was similar in the three age categories (22·7%, 17·0%, 16·3%, respectively, P = 1·0). Comparison of patient numbers between the two time periods of 5 years each showed a marked increase during 2010-2014 (148 vs 319, % increase 115·5%). The mean BMI SDSs at diagnosis in the three age categories were similar (P = 1·0) and showed a yearly change of -0·36; the mean change in the three age categories was also similar (-0·35, -0·27, -0·46, respectively, P = 1·0). No correlation was found between age at diagnosis and BMI SDSs (correlation coefficient 0·010, P = 0·82). The mean BMI SDS in patients was significantly lower compared to controls (-0·54 vs -0·02, P = 0·001). There was no association between BMI SDS and age at diagnosis in children with new onset T1D. Further studies are needed to test whether the accelerator hypothesis is relevant in developing countries. © 2015 John Wiley & Sons Ltd.

Mineral displacement and -dissolution processes and their relevance to rock porosity and permeability in Rotliegend sandstones of the Altmark natural gas field (central Germany) - results from CO2 laboratory batch experiments

NASA Astrophysics Data System (ADS)

Pudlo, Dieter; Enzmann, Frieder; Heister, Katja; Werner, Lars; Ganzer, Leonhard; Reitenbach, Viktor; Henkel, Steven; Albrecht, Daniel; Gaupp, Reinhard

2014-05-01

The Rotliegend reservoir sandstones of the Altmark area (central Germany) comprise the second largest natural gas field of Europe. These sandstones were deposited on a playa-like continental platform with braided river systems, ephemeral lakes and aeolian dunes under semi-arid conditions. Some of the pristine, red coloured deposits suffered intensive late diagenetic alteration and are now preserved as bleached, high porous and permeable sandstones. To evaluate the relevance of distinct fluids and their fluid-rock alteration reactions on such bleaching processes we performed laboratory static batch experiments on the Altmark sandstones. These 4-6 week lasting runs were conducted with CO2 saturated synthetic brines under typical Altmark reservoir conditions (p= 20 MPa, T= 125°C). Thereby mineralogical, petrophysical and (hydro- and geo-) chemical rock features were maintained prior and after the experiments. Chemical data proved the dissolution of carbonate and sulphate minerals during the runs, whereas the variation in abundance of further elements was within the detection limit of analytical accuracy. However, FE-SEM investigations on used, evaporated brines reveal the presence of illite and chlorite minerals within a matrix of Ca-, Si-, Fe, Al-, Na- and S components (carbonate, anhydrite, albite and Fe-(hydr-) oxides ?). By porosity and relative permeability measurements an increase in both rock features was observed after the runs, indicating that mineral dissolution and/or (clay) fine migration/detachment occurred during the experiments. Mineral dissolution, especially of pore-filling cements (e.g. carbonate-, sulphate minerals) is also deduced by BET analysis, in determining the specific surface of the sandstones. The size of these reactive surfaces increased after the experiments, suggesting that after the dissolution of pore-filling cements, formerly armoured grain rimming clay cutans were exposed to potential migrating fluids. These findings are also supported by µ-CT investigations. Here, the achieved 3D modelling data indicate an increase in reactive surface areas exposed to the pore space (which is in accord to the BET observations), as well as an enhancement in rock porosity and permeability after the runs. Moreover, these simulations showed that a remarkable mass (mineral) transfer was induced by the experiments, which led to a displacement of the porosity and permeability distribution in the sandstones and therefore a change in the fluid flow characteristics within the rocks - a parameter most important for every fluid-rock process. These observations are quite astonishing because they suggest that not only fluid velocity (e.g. during fluid flow experiments) might detach and transport grain rimming (clay) minerals, but also that physico-chemical reactions may enforce the release of such solids, even during almost static p-/T-/Xfluid conditions, as used in our experiments.

Validation of the model for ELM suppression with 3D magnetic fields using low torque ITER baseline scenario discharges in DIII-D

DOE PAGES

Moyer, Richard A.; Paz-Soldan, Carlos; Nazikian, Raffi; ...

2017-09-18

Here, experiments have been executed in the DIII-D tokamak to extend suppression of Edge Localized Modes (ELMs) with Resonant Magnetic Perturbations (RMPs) to ITER-relevant levels of beam torque. The results support the hypothesis for RMP ELM suppression based on transition from an ideal screened response to a tearing response at a resonant surface that prevents expansion of the pedestal to an unstable width.

Comparative safety and efficacy of insulin degludec with insulin glargine in type 2 and type 1 diabetes: a meta-analysis of randomized controlled trials.

PubMed

Zhang, Xiao-Wen; Zhang, Xin-Lin; Xu, Biao; Kang, Li-Na

2018-05-01

To determine the safety and efficacy of insulin degludec versus glargine in patients with type 1 (T1D) and type 2 (T2D) diabetes mellitus. Databases were searched until July 5, 2017. We included randomized controlled trials comparing degludec with glargine in diabetic patients, each with a minimum of 16 weeks of follow-up. Eighteen trials with 16,791 patients were included. Degludec was associated with a statistically significant reduction in risk for all confirmed hypoglycemia at the maintenance treatment period [estimated rate ratio (ERR) 0.81; 95% confidence interval (CI) 0.72‒0.92; P = 0.001], nocturnal confirmed hypoglycemia at the entire (ERR 0.71; 95% CI 0.63‒0.80; P < 0.001) and maintenance treatment period (ERR 0.65; 95% CI 0.59‒0.71; P < 0.001), all irrespective of the pooled diabetic populations and follow-up durations. The differences in the rate of hypoglycemia were more pronounced in nocturnal period and maintenance period and in T2D than T1D patients. Degludec reduced the incidence of severe hypoglycemia in T2D [ERR 0.65; (0.52; 0.89); P = 0.005] but not T1D patients. HbA1c concentration was slightly higher in degludec over glargine but was not clinically relevant [estimated treatment difference (ETD) 0.03; 95% CI - 0.00 to 0.06%; P = 0.06]. Fasting plasma glucose level was lower in degludec-treated patients (ETD - 0.28 mmol/L; 95% CI - 0.44 to - 0.11 mmol/L; P = 0.001). Several subgroup analyses showed largely consistent findings. The rates of adverse events including total mortality and cardiovascular events were not significantly different between two treatment strategies. Insulin degludec appears to have better safety in reducing hypoglycemic events with similar efficacy compared with insulin glargine.

Unconventional antiferromagnetic correlations of the doped Haldane gapsystem Y 2 BaNi 1 - x Zn x O 5

NASA Astrophysics Data System (ADS)

Villar, V.; Mélin, R.; Paulsen, C.; Souletie, J.; Janod, E.; Payen, C.

2002-01-01

We make a new proposal to describe the very low temperature susceptibility of the doped Haldane gap compound Y2BaNi1-xZnxO5. We propose a new mean field model relevant for this compound. The ground state of this mean field model is unconventional because antiferromagnetism coexists with random dimers. We present new susceptibility experiments at very low temperature. We obtain a Curie-Weiss susceptibility χ(T) C/(Θ + T) as expected for antiferromagnetic correlations but we do not obtain a direct signature of antiferromagnetic long range order. We explain how to obtain the ``impurity'' susceptibility (T) by subtracting the Haldane gap contribution to the total susceptibility. In the temperature range [1 K, 300 K] the experimental data are well fitted by T (T) = Cimp 1 + Timp/T . In the temperature range [100 mK, 1 K] the experimental data are well fitted by T (T) = A ln(T/Tc), where Tc increases with x. This fit suggests the existence of a finite Néel temperature which is however too small to be probed directly in our experiments. We also obtain a maximum in the temperature dependence of the ac-susceptibility (T) which suggests the existence of antiferromagnetic correlations at very low temperature.

Imprints of a light sterile neutrino at DUNE, T2HK, and T2HKK

NASA Astrophysics Data System (ADS)

Choubey, Sandhya; Dutta, Debajyoti; Pramanik, Dipyaman

2017-09-01

We evaluate the impact of sterile neutrino oscillations in the so-called 3 +1 scenario on the proposed long baseline experiment in USA and Japan. There are two proposals for the Japan experiment which are called T2HK and T2HKK. We show the impact of sterile neutrino oscillation parameters on the expected sensitivity of T2HK and T2HKK to mass hierarchy, C P violation and octant of θ23 and compare it against that expected in the case of standard oscillations. We add the expected ten years data from DUNE and present the combined expected sensitivity of T 2 HKK +DUNE to the oscillation parameters. We do a full marginalization over the relevant parameter space and show the effect of the magnitude of the true sterile mixing angles on the physics reach of these experiments. We show that if one assumes that the source of C P violation is the standard C P phase alone in the test case, then it appears that the expected C P violation sensitivity decreases due to sterile neutrinos. However, if we give up this assumption, then the C P sensitivity could go in either direction. The impact on expected octant of θ23 and mass hierarchy sensitivity is shown to depend on the magnitude of the sterile mixing angles in a nontrivial way.

What role could community pharmacists in Malaysia play in diabetes self-management education and support? The views of individuals with type 2 diabetes.

PubMed

Lee, E Lyn; Wong, Pei Se; Tan, Ming Yeong; Sheridan, Janie

2018-04-01

This study explored the experiences and views of individuals with type 2 diabetes mellitus (T2D) on their diabetes self-management and potential roles for community pharmacists in diabetes self-management education and support (DSME/S) in Malaysia. A qualitative study, using semi-structured, face-to-face interviews, was conducted with patients with T2D attending a primary care health clinic in Kuala Lumpur, Malaysia. The interviews were audio-recorded, transcribed verbatim and analysed inductively. Fourteen participants with T2D were interviewed. Data were coded into five main themes: experience and perception of diabetes self-management, constraints of the current healthcare system, perception of the community pharmacist and community pharmacies, perceived roles for community pharmacists in diabetes care, and challenges in utilising community pharmacies to provide DSME/S. There were misconceptions about diabetes management that may be attributed to a lack of knowledge. Although participants described potential roles for community pharmacists in education, medication review and continuity of care, these roles were mostly non-clinically oriented. Participants were not confident about community pharmacists making recommendations and changes to the prescribed treatment regimens. While participants recognised the advantages of convenience of a community pharmacy-based diabetes care service, they raised concerns over the retail nature and the community pharmacy environment for providing such services. This study highlighted the need to improve the care provision for people with T2D. Participants with T2D identified potential, but limited roles for community pharmacists in diabetes care. Participants expressed concerns that need to be addressed if effective diabetes care is to be provided from community pharmacies in Malaysia. © 2017 Royal Pharmaceutical Society.

Compilation of Reprints Number 64.

DTIC Science & Technology

1987-11-01

EFFECT 01 llt’ItRO(;lNEN II 1 S IN "D)" ON Till: DUlCA reprint R..VIT OF 6) D tI, PERFORMING ORG. REPORT NUMBER 7 AUTHoR(.) S CONTRACT OR GRANT NUMBER...I MENKt;, WILLI:\\M NO0() 14- 84 - C- 0218 9 PERFORMING ORGANIZATION NAME AND ADORESS 10 PROGRAM ELEMENT, PROJECT TASK AREA & WORK UNIT NUMBERS...mainly increase it. We did not identify any major effect of scatterer aspect ratio on the decay rate in the one relevant test that we performed (dikes

Ophthalmic magnetic resonance imaging at 7 T using a 6-channel transceiver radiofrequency coil array in healthy subjects and patients with intraocular masses.

PubMed

Graessl, Andreas; Muhle, Maximilian; Schwerter, Michael; Rieger, Jan; Oezerdem, Celal; Santoro, Davide; Lysiak, Darius; Winter, Lukas; Hezel, Fabian; Waiczies, Sonia; Guthoff, Rudolf F; Falke, Karen; Hosten, Norbert; Hadlich, Stefan; Krueger, Paul-Christian; Langner, Soenke; Stachs, Oliver; Niendorf, Thoralf

2014-05-01

This study was designed to examine the feasibility of ophthalmic magnetic resonance imaging (MRI) at 7 T using a local 6-channel transmit/receive radiofrequency (RF) coil array in healthy volunteers and patients with intraocular masses. A novel 6-element transceiver RF coil array that makes uses of loop elements and that is customized for eye imaging at 7 T is proposed. Considerations influencing the RF coil design and the characteristics of the proposed RF coil array are presented. Numerical electromagnetic field simulations were conducted to enhance the RF coil characteristics. Specific absorption rate simulations and a thorough assessment of RF power deposition were performed to meet the safety requirements. Phantom experiments were carried out to validate the electromagnetic field simulations and to assess the real performance of the proposed transceiver array. Certified approval for clinical studies was provided by a local notified body before the in vivo studies. The suitability of the RF coil to image the human eye, optical nerve, and orbit was examined in an in vivo feasibility study including (a) 3-dimensional (3D) gradient echo (GRE) imaging, (b) inversion recovery 3D GRE imaging, and (c) 2D T2-weighted fast spin-echo imaging. For this purpose, healthy adult volunteers (n = 17; mean age, 34 ± 11 years) and patients with intraocular masses (uveal melanoma, n = 5; mean age, 57 ± 6 years) were investigated. All subjects tolerated all examinations well with no relevant adverse events. The 6-channel coil array supports high-resolution 3D GRE imaging with a spatial resolution as good as 0.2 × 0.2 × 1.0 mm, which facilitates the depiction of anatomical details of the eye. Rather, uniform signal intensity across the eye was found. A mean signal-to-noise ratio of approximately 35 was found for the lens, whereas the vitreous humor showed a signal-to-noise ratio of approximately 30. The lens-vitreous humor contrast-to-noise ratio was 8, which allows good differentiation between the lens and the vitreous compartment. Inversion recovery prepared 3D GRE imaging using a spatial resolution of 0.4 × 0.4 × 1.0 mm was found to be feasible. T2-weighted 2D fast spin-echo imaging with the proposed RF coil afforded a spatial resolution of 0.25 × 0.25 × 0.7 mm. This work provides valuable information on the feasibility of ophthalmic MRI at 7 T using a dedicated 6-channel transceiver coil array that supports the acquisition of high-contrast, high-spatial resolution images in healthy volunteers and patients with intraocular masses. The results underscore the challenges of ocular imaging at 7 T and demonstrate that these issues can be offset by using tailored RF coil hardware. The benefits of such improvements would be in positive alignment with explorations that are designed to examine the potential of MRI for the assessment of spatial arrangements of the eye segments and their masses with the ultimate goal to provide imaging means for guiding treatment decisions in ophthalmological diseases.

Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles

PubMed Central

Speiseder, Thomas; Badbaran, Anita; Reimer, Rudolph; Indenbirken, Daniela; Grundhoff, Adam; Brunswig-Spickenheier, Bärbel; Alawi, Malik; Lange, Claudia

2016-01-01

The biological relevance of extracellular vesicles (EV) in intercellular communication has been well established. Thus far, proteins and RNA were described as main cargo. Here, we show that EV released from human bone marrow derived mesenchymal stromal cells (BM-hMSC) also carry high-molecular DNA in addition. Extensive EV characterization revealed this DNA mainly associated with the outer EV membrane and to a smaller degree also inside the EV. Our EV purification protocol secured that DNA is not derived from apoptotic or necrotic cells. To analyze the relevance of EV-associated DNA we lentivirally transduced Arabidopsis thaliana-DNA (A.t.-DNA) as indicator into BM-hMSC and generated EV. Using quantitative polymerase chain reaction (qPCR) techniques we detected high copy numbers of A.t.-DNA in EV. In recipient hMSC incubated with tagged EV for two weeks we identified A.t.-DNA transferred to recipient cells. Investigation of recipient cell DNA using quantitative PCR and verification of PCR-products by sequencing suggested stable integration of A.t.-DNA. In conclusion, for the first time our proof-of-principle experiments point to horizontal DNA transfer into recipient cells via EV. Based on our results we assume that eukaryotic cells are able to exchange genetic information in form of DNA extending the known cargo of EV by genomic DNA. This mechanism might be of relevance in cancer but also during cell evolution and development. PMID:27684368

Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles.

PubMed

Fischer, Stefanie; Cornils, Kerstin; Speiseder, Thomas; Badbaran, Anita; Reimer, Rudolph; Indenbirken, Daniela; Grundhoff, Adam; Brunswig-Spickenheier, Bärbel; Alawi, Malik; Lange, Claudia

The biological relevance of extracellular vesicles (EV) in intercellular communication has been well established. Thus far, proteins and RNA were described as main cargo. Here, we show that EV released from human bone marrow derived mesenchymal stromal cells (BM-hMSC) also carry high-molecular DNA in addition. Extensive EV characterization revealed this DNA mainly associated with the outer EV membrane and to a smaller degree also inside the EV. Our EV purification protocol secured that DNA is not derived from apoptotic or necrotic cells. To analyze the relevance of EV-associated DNA we lentivirally transduced Arabidopsis thaliana-DNA (A.t.-DNA) as indicator into BM-hMSC and generated EV. Using quantitative polymerase chain reaction (qPCR) techniques we detected high copy numbers of A.t.-DNA in EV. In recipient hMSC incubated with tagged EV for two weeks we identified A.t.-DNA transferred to recipient cells. Investigation of recipient cell DNA using quantitative PCR and verification of PCR-products by sequencing suggested stable integration of A.t.-DNA. In conclusion, for the first time our proof-of-principle experiments point to horizontal DNA transfer into recipient cells via EV. Based on our results we assume that eukaryotic cells are able to exchange genetic information in form of DNA extending the known cargo of EV by genomic DNA. This mechanism might be of relevance in cancer but also during cell evolution and development.

S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells

PubMed Central

Guzmán, Esther A.; Langowski, John L.; De Guzman, Ariel; Konrad Muller, H.; Walker, Ameae M.; Owen, Laurie B.

2008-01-01

Epidermal gamma delta T cells (γδ T) and Langerhans cells (LC) are immune cells altered by exposure to ultraviolet radiation (UVB), a powerful stressor resulting in immune suppression. Prolactin (PRL) has been characterized as an immunomodulator, particularly during stress. In this study, we have asked whether separate administration of the two major forms of prolactin, unmodified and phosphorylated, to groups of 15 mice (3 experiments, each with 5 mice per treatment group) affected the number and morphology of these epidermal immune cells under control conditions, and following UV irradiation. Under control conditions, both PRLs reduced the number of γδ T, but a molecular mimic of phosphorylated PRL (S179D PRL) was more effective, resulting in a 30% reduction. In the irradiated group, however, S179D PRL was protective against a UV-induced reduction in γδ T number and change in morphology (halved the reduction and normalized the morphology). In addition, S179D PRL, but not unmodified (U-PRL), maintained a normal LC: γδ T ratio and sustained the dendritic morphology of LC after UV exposure. These findings suggest that S179D PRL may have an overall protective effect, countering UV-induced cellular alterations in the epidermis. PMID:17945411

A Bayesian network model for predicting type 2 diabetes risk based on electronic health records

NASA Astrophysics Data System (ADS)

Xie, Jiang; Liu, Yan; Zeng, Xu; Zhang, Wu; Mei, Zhen

2017-07-01

An extensive, in-depth study of diabetes risk factors (DBRF) is of crucial importance to prevent (or reduce) the chance of suffering from type 2 diabetes (T2D). Accumulation of electronic health records (EHRs) makes it possible to build nonlinear relationships between risk factors and diabetes. However, the current DBRF researches mainly focus on qualitative analyses, and the inconformity of physical examination items makes the risk factors likely to be lost, which drives us to study the novel machine learning approach for risk model development. In this paper, we use Bayesian networks (BNs) to analyze the relationship between physical examination information and T2D, and to quantify the link between risk factors and T2D. Furthermore, with the quantitative analyses of DBRF, we adopt EHR and propose a machine learning approach based on BNs to predict the risk of T2D. The experiments demonstrate that our approach can lead to better predictive performance than the classical risk model.

Evolution of ferromagnetism in two-dimensional electron gas of LaTiO3/SrTiO3

NASA Astrophysics Data System (ADS)

Wen, Fangdi; Cao, Yanwei; Liu, Xiaoran; Pal, B.; Middey, S.; Kareev, M.; Chakhalian, J.

2018-03-01

Understanding, creating, and manipulating spin polarization of two-dimensional electron gases at complex oxide interfaces present an experimental challenge. For example, despite almost a decade long research effort, the microscopic origin of ferromagnetism in LaAlO3/SrTiO3 heterojunctions is still an open question. Here, by using a prototypical two-dimensional electron gas (2DEG) which emerges at the interface between band insulator SrTiO3 and antiferromagnetic Mott insulator LaTiO3, the experiment reveals the evidence for magnetic phase separation in a hole-doped Ti d1 t2g system, resulting in spin-polarized 2DEG. The details of electronic and magnetic properties of the 2DEG were investigated by temperature-dependent d.c. transport, angle-dependent X-ray photoemission spectroscopy, and temperature-dependent magnetoresistance. The observation of clear hysteresis in magnetotransport at low magnetic fields implies spin-polarization from magnetic islands in the hole rich LaTiO3 near the interface. These findings emphasize the role of magnetic instabilities in doped Mott insulators, thus providing another path for designing all-oxide structures relevant to spintronic applications.

Comment on "Measurements without probabilities in the final state proposal"

NASA Astrophysics Data System (ADS)

Cohen, Eliahu; Nowakowski, Marcin

2018-04-01

The final state proposal [G. T. Horowitz and J. M. Maldacena, J. High Energy Phys. 04 (2004) 008, 10.1088/1126-6708/2004/04/008] is an attempt to relax the apparent tension between string theory and semiclassical arguments regarding the unitarity of black hole evaporation. Authors Bousso and Stanford [Phys. Rev. D 89, 044038 (2014), 10.1103/PhysRevD.89.044038] analyze thought experiments where an infalling observer first verifies the entanglement between early and late Hawking modes and then verifies the interior purification of the same Hawking particle. They claim that "probabilities for outcomes of these measurements are not defined" and therefore suggest that "the final state proposal does not offer a consistent alternative to the firewall hypothesis." We show, in contrast, that one may define all the relevant probabilities based on the so-called ABL rule [Y. Aharonov, P. G. Bergmann, and J. L. Lebowitz, Phys. Rev. 134, B1410 (1964), 10.1103/PhysRev.134.B1410], which is better suited for this task than the decoherence functional. We thus assert that the analysis of Bousso and Stanford cannot yet rule out the final state proposal.

Characterization of Electron Temperature and Density Profiles of Plasmas Produced by Nike KrF Laser for Laser Plasma Instability (LPI) Research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Phillips, L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Chan, L.-Y.; Serlin, V.

2011-10-01

Previous experiments with Nike KrF laser (λ = 248 nm , Δν ~ 1 THz) observed LPI signatures near quarter critical density (nc / 4) in CH plasmas, however, detailed measurement of the temperature (Te) and density (ne) profiles was missing. The current Nike LPI campaign will perform experimental determination of the plasma profiles. A side-on grid imaging refractometer (GIR) is the main diagnostic to resolve Te and ne in space taking 2D snapshots of probe laser (λ = 266 nm , Δt = 8 psec) beamlets (50 μm spacing) refracted by the plasma at laser peak time. Ray tracing of the beamlets through hydrodynamically simulated (FASTRAD3D) plasma profiles estimates the refractometer may access densities up to ~ 0 . 2nc . With the measured Te and ne profiles in the plasma corona, we will discuss analysis of light data radiated from the plasmas in spectral ranges relevant to two plasmon decay and convective Raman instabilities. Validity of the (Te ,ne) data will also be discussed for the thermal transport study. Work supported by DoE/NNSA and ONR and performed at NRL.

Naval Research Laboratory Multiscale Targeting Guidance for T-PARC and TCS-08

DTIC Science & Technology

2010-01-01

Naval Research Laboratory Multiscale Targeting Guidance for T- PARC and TCS-08 CAROLYN A. REYNOLDS AND JAMES D. DOYLE Marine Meteorology Division...of The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T- PARC ) and the Office of Naval Research’s...These products were produced with 24-, 36-, and 48-h lead times. The nonhydrostatic adjoint system used during T- PARC /TCS-08 contains an exact adjoint to

Magnetocaloric behavior in ternary europium indides EuT 5In: Probing the design capability of first-principles-based methods on the multifaceted magnetic materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bigun, Inna; Steinberg, Simon; Smetana, Volodymyr

The most favorable structures and the types of magnetic ordering predicted from first-principles-based methods in a family of closely related transition-metal-rich indides EuT 5In (T = Cu, Ag, Au) are gauged against relevant experiments. The EuT5In compounds adopt a different structure for each different coinage metal—EuCu 5In ( hR42; Rmore » $$\\overline{3}$$m, a = 5.0933(7), c = 30.557(6) Å), EuAg 5In ( oP28; Pnma, a = 9.121(2), b = 5.645(1), c = 11.437(3) Å), and EuAu 5In ( tI14; I4/ mmm, a = 7.1740(3), c = 5.4425(3) Å)—and crystallize with the Sr 5Al 9, CeCu 6, and YbMo 2Al 4 structure types, respectively. EuCu 5In and EuAg 5In order antiferromagnetically at T N = 12 and 6 K, respectively, whereas EuAu 5In is ferromagnetic below T C = 13 K. EuCu 5In exhibits complex magnetism: after the initial drop at T N, the magnetization rises again below 8 K, and a weak metamagnetic-like transition occurs at 2 K in μ 0H = 1.8 T. The electronic heat capacity of EuCu 5In, γ = ~400 mJ/(mol K 2), points to strong electronic correlations. Spin-polarized densities of states suggest that the magnetic interactions in the three materials studied are supported via mixing 4 f and 5 d states of Eu. As a result, a chemical bonding analysis based on the Crystal Orbital Hamilton populations reveals the tendency to maximize overall bonding as a driving force to adopt a particular type of crystal structure.« less

Magnetocaloric behavior in ternary europium indides EuT 5In: Probing the design capability of first-principles-based methods on the multifaceted magnetic materials

DOE PAGES

Bigun, Inna; Steinberg, Simon; Smetana, Volodymyr; ...

2017-01-27

The most favorable structures and the types of magnetic ordering predicted from first-principles-based methods in a family of closely related transition-metal-rich indides EuT 5In (T = Cu, Ag, Au) are gauged against relevant experiments. The EuT5In compounds adopt a different structure for each different coinage metal—EuCu 5In ( hR42; Rmore » $$\\overline{3}$$m, a = 5.0933(7), c = 30.557(6) Å), EuAg 5In ( oP28; Pnma, a = 9.121(2), b = 5.645(1), c = 11.437(3) Å), and EuAu 5In ( tI14; I4/ mmm, a = 7.1740(3), c = 5.4425(3) Å)—and crystallize with the Sr 5Al 9, CeCu 6, and YbMo 2Al 4 structure types, respectively. EuCu 5In and EuAg 5In order antiferromagnetically at T N = 12 and 6 K, respectively, whereas EuAu 5In is ferromagnetic below T C = 13 K. EuCu 5In exhibits complex magnetism: after the initial drop at T N, the magnetization rises again below 8 K, and a weak metamagnetic-like transition occurs at 2 K in μ 0H = 1.8 T. The electronic heat capacity of EuCu 5In, γ = ~400 mJ/(mol K 2), points to strong electronic correlations. Spin-polarized densities of states suggest that the magnetic interactions in the three materials studied are supported via mixing 4 f and 5 d states of Eu. As a result, a chemical bonding analysis based on the Crystal Orbital Hamilton populations reveals the tendency to maximize overall bonding as a driving force to adopt a particular type of crystal structure.« less

Animal models of transcranial direct current stimulation: Methods and mechanisms.

PubMed

Jackson, Mark P; Rahman, Asif; Lafon, Belen; Kronberg, Gregory; Ling, Doris; Parra, Lucas C; Bikson, Marom

2016-11-01

The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: (1) transcranial stimulation; (2) direct cortical stimulation in vivo and (3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching "quasi-uniform" assumption, which underpins translational relevance in all animal models of tDCS. Terminology such as anode, cathode, inward current, outward current, current density, electric field, and uniform are defined. Though we put key animal experiments spanning decades in perspective, our goal is not simply an exhaustive cataloging of relevant animal studies, but rather to put them in context of ongoing efforts to improve tDCS. Cellular targets, including excitatory neuronal somas, dendrites, axons, interneurons, glial cells, and endothelial cells are considered. We emphasize neurons are always depolarized and hyperpolarized such that effects of DCS on neuronal excitability can only be evaluated within subcellular regions of the neuron. Findings from animal studies on the effects of DCS on plasticity (LTP/LTD) and network oscillations are reviewed extensively. Any endogenous phenomena dependent on membrane potential changes are, in theory, susceptible to modulation by DCS. The relevance of morphological changes (galvanotropy) to tDCS is also considered, as we suggest microscopic migration of axon terminals or dendritic spines may be relevant during tDCS. A majority of clinical studies using tDCS employ a simplistic dose strategy where excitability is singularly increased or decreased under the anode and cathode, respectively. We discuss how this strategy, itself based on classic animal studies, cannot account for the complexity of normal and pathological brain function, and how recent studies have already indicated more sophisticated approaches are necessary. One tDCS theory regarding "functional targeting" suggests the specificity of tDCS effects are possible by modulating ongoing function (plasticity). Use of animal models of disease are summarized including pain, movement disorders, stroke, and epilepsy. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Animal Models of transcranial Direct Current Stimulation: Methods and Mechanisms

PubMed Central

Jackson, Mark P.; Rahman, Asif; Lafon, Belen; Kronberg, Gregory; Ling, Doris; Parra, Lucas C.; Bikson, Marom

2016-01-01

The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: 1) transcranial stimulation; 2) direct cortical stimulation in vivo and 3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching “quasi-uniform” assumption, which underpins translational relevance in all animal models of tDCS. Terminology such as anode, cathode, inward current, outward current, current density, electric field, and uniform are defined. Though we put key animal experiments spanning decades in perspective, our goal is not simply an exhaustive cataloging of relevant animal studies, but rather to put them in context of ongoing efforts to improve tDCS. Cellular targets, including excitatory neuronal somas, dendrites, axons, interneurons, glial cells, and endothelial cells are considered. We emphasize neurons are always depolarized and hyperpolarized such that effects of DCS on neuronal excitability can only be evaluated within subcellular regions of the neuron. Findings from animal studies on the effects of DCS on plasticity (LTP/LTD) and network oscillations are reviewed extensively. Any endogenous phenomena dependent on membrane potential changes are, in theory, susceptible to modulation by DCS. The relevance of morphological changes (galvanotropy) to tDCS is also considered, as we suggest microscopic migration of axon terminals or dendritic spines may be relevant during tDCS. A majority of clinical studies using tDCS employ a simplistic dose strategy where excitability is singularly increased or decreased under the anode and cathode, respectively. We discuss how this strategy, itself based on classic animal studies, cannot account for the complexity of normal and pathological brain function, and how recent studies have already indicated more sophisticated approaches are necessary. One tDCS theory regarding “functional targeting” suggests the specificity of tDCS effects are possible by modulating ongoing function (plasticity). Use of animal models of disease are summarized including pain, movement disorders, stroke, and epilepsy. PMID:27693941

Physical Properties of AZ91D Measured Using the Draining Crucible Method: Effect of SF6

NASA Astrophysics Data System (ADS)

Roach, Steven J.; Henein, Hani

2012-03-01

The draining crucible (DC) technique was used for measurements on AZ91D under Ar and SF6. The DC technique is a new method developed to simultaneously measure the physical properties of fluids, the density, surface tension, and viscosity. Based on the relationship between the height of a metal in a crucible and the outgoing flow rate, a multi-variable regression is used to calculate the values of these fluid properties. Experiments performed with AZ91D at temperatures from 923 K to 1173 K indicate that under argon, the surface tension (N · m-1) and density (kg · m-3) are [0.63 - 2.13 × 10-4 ( T - T L)] and [1656 - 0.158 ( T - T L)], respectively. The viscosity (Pa · s) has been determined to be [1.455 × 10-3 - 1.209 × 10-5 ( T - T L)] over the temperature range from 921 K to 967 K superheat. Above 967 K, the viscosity of the alloy under argon seems to be constant at (2.66 × 10-4 ± 8.67 × 10-5) Pa · s. SF6 reduces the surface tension of AZ91D.

Deformation and seismic anisotropy of silicate post-perovskite in the Earth's lowermost mantle

NASA Astrophysics Data System (ADS)

wu, X.; Lin, J.; Mao, Z.; Liu, J.; Kaercher, P. M.; Wenk, H.; Prakapenka, V.; Zhuravlev, K. K.

2013-12-01

The D' layer in the Earth's lowermost mantle with an average thickness of 250 km right above the core-mantle boundary plays a significant role in the geophysics, geochemistry, and geodynamics of the planet's interior. Seismic observations of the region have shown a number of enigmatic features including shear wave discontinuity and seismic wave anisotropy. The seismic anisotropy, in which the horizontally-polarized shear wave (VSH) travels faster than the vertically-polarized shear wave (VSV) by 1%~3% in areas below the circum Pacific, has been proposed to be a result of the lattice-preferred orientation of silicate post-perovskite (PPv) that is to be the most abundant phase in the D' layer [1]. Therefore, understanding the elasticity and deformation of the PPv phase is critical under relevant P-T conditions of the region. However, experimental results on the textures and the elastic anisotropy of PPv remain largely limited and controversial. Specifically, a number of slip systems of PPv, such as (010), (100), (110) and (001), have been proposed based on experimental and theoretical results [2-4]. Here we have studied the textures and deformation mechanism of iron-bearing PPv ((Mg0.75,Fe0.25)SiO3) at relevant P-T conditions of the lowermost mantle using synchrotron radiation radial x-ray diffraction in a membrane-driven laser-heated diamond anvil cell. The diffraction patterns were recorded from the laser-heated PPv sample during further compression between 130 GPa and 150 GPa. Analyses of the diffraction patterns and simulation results from viscoplastic self-consistent polycrystal plasticity code (VPSC) show that the development of active slip systems can be strongly influenced by experimental pressure-temperature-time conditions. At relevant P-T conditions of the lowermost mantle, our results demonstrate that the dominant slip systems of PPv should be (001)[100] and (001)[010]. Combined these results with the elasticity of PPv, we provide more constrains on the geodynamic model and interpret the potential mechanism of the seismic anisotropy origin of the D' layer. [1] Nowacki A, Wookey J, and Kendall, Nature 467, 1091 (2010). [2] Merkel S, McNamara A K, Kubo A, Speziale S, Miyagi L, Meng Y, Duffy T S, and Wenk H R, Science 316, 1729 (2007). [3] Miyagi L, Kanitpanyacharoen W, Kaercher P, Lee K K M, and Wenk H R, Sicence 329, 1639 (2010). [4] Metsue A, and Tsuchiya T, Proc. Jpn. Acad., Ser. B89, 51 (2013).

Spectroscopic Investigation of O-,M-, and P-Cyanostyrenes

NASA Astrophysics Data System (ADS)

Korn, Joseph A.; Knezz, Stephanie N.; McMahon, Robert J.; Zwier, Timothy S.

2014-06-01

The atmosphere of Titan contains nitrogen, methane, and a rich mixture of more complex hydrocarbons and nitriles produced by photochemical processing. Data from the 2005 Cassini-Huygens mission suggests that among the more complex compounds are substituted benzenes that are themselves precursors to large polymeric tholins. Nitriles are particularly prevalent in Titan's atmosphere due to the dominance of N2 in the atmosphere. The cyanostyrenes are of particular interest, in part because they have the same molecular formula (C9H7N) as quinoline, a prototypical heteroaromatic, and therefore could engage in photochemical isomerization to form this molecule of significant pre-biotic relevance. As a first step in understanding the pathways leading to heteroaromatics, we have studied the isotope-selective spectroscopy of o-,m-, and p-cyanostyrene under jet-cooled conditions relevant to Titan's atmosphere. In this talk, the excitation and emission spectra for the three isomers will be presented. Using a combination of resonant two-photon ionization, LIF excitation, and dispersed fluorescence spectroscopies, the vibronic spectroscopy of the three isomers were recorded and compared. The meta isomer has two conformational isomers, which have been distinguished and studied using hole-burning methods. The talk will compare and contrast the UV spectral signatures of the set of structural and conformational isomers of the cyanostyrenes, using the ethynylstyrene counterparts as points of comparison. Sebree, J. A.; Kidwell, N. M.; Selby, T. M.; Amberger, B. K.; McMahon, R. J.; Zwier, T. S., Photochemistry of Benzylallene: Ring-Closing Reactions to Form Naphthalene. Journal of the American Chemical Society 2012, 134 (2), 1153-1163. Selby, T. M.; Clarkson, J. R.; Mitchell, D.; Fitzpatrick, J. A. J.; Lee, H. D.; Pratt, D. W.; Zwier, T. S., Isomer-Specific Spectroscopy and Conformational Isomerization Energetics of o-, m-, and p-Ethynylstyrenes. The Journal of Physical Chemistry A 2005, 109 (20), 4484-4496.

Measuring 20-100 T B-fields using Zeeman splitting of sodium emission lines on a 500 kA pulsed power machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banasek, J. T., E-mail: jtb254@cornell.edu; Engelbrecht, J. T.; Pikuz, S. A.

2016-11-15

We have shown that Zeeman splitting of the sodium (Na) D-lines at 5890 and 5896 Å can be used to measure the magnetic field (B-field) produced in high current pulsed power experiments. We have measured the B-field next to a return current conductor in a hybrid X-pinch experiment near a peak current of about 500 kA. Na is deposited on the conductor and then is desorbed and excited by radiation from the hybrid X-pinch. The D-line emission spectrum implies B-fields of about 20 T with a return current post of 4 mm diameter or up to 120 T with amore » return current wire of 0.455 mm diameter. These measurements were consistent or lower than the expected B-field, thereby showing that basic Zeeman splitting can be used to measure the B-field in a pulsed-power-driven high-energy-density (HED) plasma experiment. We hope to extend these measurement techniques using suitable ionized species to measurements within HED plasmas.« less

Prestructural cartilage assessment using MRI.

PubMed

Link, Thomas M; Neumann, Jan; Li, Xiaojuan

2017-04-01

Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy. Moreover, we highlighted important clinical applications. This review article focuses on the currently most relevant and clinically applicable technologies, such as T2 mapping, T2*, T1ρ, delayed gadolinium enhanced MRI of cartilage (dGEMRIC), sodium imaging and glycosaminoglycan chemical exchange saturation transfer (gagCEST). To date, most information is available for T2 and T1ρ mapping. dGEMRIC has also been used in multiple clinical studies, although it requires Gd contrast administration. Sodium imaging and gagCEST are promising technologies but are dependent on high field strength and sophisticated software and hardware. 5 J. Magn. Reson. Imaging 2017;45:949-965. © 2016 International Society for Magnetic Resonance in Medicine.

Initial experience with 3D isotropic high-resolution 3 T MR arthrography of the wrist.

PubMed

Sutherland, John K; Nozaki, Taiki; Kaneko, Yasuhito; J Yu, Hon; Rafijah, Gregory; Hitt, David; Yoshioka, Hiroshi

2016-01-16

Our study was performed to evaluate the image quality of 3 T MR wrist arthrograms with attention to ulnar wrist structures, comparing image quality of isotropic 3D proton density fat suppressed turbo spin echo (PDFS TSE) sequence versus standard 2D 3 T sequences as well as comparison with 1.5 T MR arthrograms. Eleven consecutive 3 T MR wrist arthrograms were performed and the following sequences evaluated: 3D isotropic PDFS, repetition time/echo time (TR/TE) 1400/28.3 ms, voxel size 0.35x0.35x0.35 mm, acquisition time 5 min; 2D coronal sequences with slice thickness 2 mm: T1 fat suppressed turbo spin echo (T1FS TSE) (TR/TE 600/20 ms); proton density (PD) TSE (TR/TE 3499/27 ms). A 1.5 T group of 18 studies with standard sequences were evaluated for comparison. All MR imaging followed fluoroscopically guided intra-articular injection of dilute gadolinium contrast. Qualitative assessment related to delineation of anatomic structures between 1.5 T and 3 T MR arthrograms was carried out using Mann-Whitney test and the differences in delineation of anatomic structures among each sequence in 3 T group were analyzed with Wilcoxon signed-rank test. Quantitative assessment of mean relative signal intensity (SI) and relative contrast measurements was performed using Wilcoxon signed-rank test. Mean qualitative scores for 3 T sequences were significantly higher than 1.5 T (p < 0.01), with isotropic 3D PDFS sequence having highest mean qualitative scores (p < 0.05). Quantitative analysis demonstrated no significant difference in relative signal intensity among the 3 T sequences. Significant differences were found in relative contrast between fluid-bone and fluid-fat comparing 3D and 2D PDFS (p < 0.01). 3D isotropic PDFS sequence showed promise in both qualitative and quantitative assessment, suggesting this may be useful for MR wrist arthrograms at 3 T. Primary reasons for diagnostic potential include the ability to make reformations in any obliquity to follow the components of ulnar side wrist structures including triangular fibrocartilage complex. Additionally, isotropic imaging provides thinner slice thickness with less partial volume averaging allowing for identification of subtle injuries.

Deciphering the Mechanism of Alternative Cleavage and Polyadenylation in Mantle Cell Lymphoma (MCL)

DTIC Science & Technology

2014-10-01

Kubo , T., Wada, T., Yamaguchi, Y., Shimizu, A. & Handa, H. Knock-down of 25 kDa subunit of cleavage factor Im inHela cells alters alternative...usage was calculated as 62normalized DDDCT. Oligonucleotides used for qRT–PCR. Cyclin D1 common forward, 59-CTGC CAGGAGCAGATCGAAG; reverse, 59...CTdeviation of either amplicon at all of the dilutions was calculated as a correction factor. d, The experiment shown in c was repeated for DICER1 and

Development of a Tritium Extruder for ITER Pellet Injection

DOE Office of Scientific and Technical Information (OSTI.GOV)

M.J. Gouge; P.W. Fisher

As part of the International Thermonuclear Experimental Reactor (ITER) plasma fueling development program, Oak Ridge National Laboratory (ORNL) has fabricated a pellet injection system to test the mechanical and thermal properties of extruded tritium. Hydrogenic pellets will be used in ITER to sustain the fusion power in the plasma core and may be crucial in reducing first-wall tritium inventories by a process of "isotopic fueling" in which tritium-rich pellets fuel the burning plasma core and deuterium gas fuels the edge. This repeating single-stage pneumatic pellet injector, called the Tritium-Proof-of-Principle Phase II (TPOP-II) Pellet Injector, has a piston-driven mechanical extruder andmore » is designed to extrude and accelerate hydrogenic pellets sized for the ITER device. The TPOP-II program has the following development goals: evaluate the feasibility of extruding tritium and deuterium-tritium (D-T) mixtures for use in future pellet injection systems; determine the mechanical and thermal properties of tritium and D-T extrusions; integrate, test, and evaluate the extruder in a repeating, single-stage light gas gun that is sized for the ITER application (pellet diameter -7 to 8 mm); evaluate options for recycling propellant and extruder exhaust gas; and evaluate operability and reliability of ITER prototypical fueling systems in an environment of significant tritium inventory that requires secondary and room containment systems. In tests with deuterium feed at ORNL, up to 13 pellets per extrusion have been extruded at rates up to 1 Hz and accelerated to speeds of 1.0 to 1.1 km/s, using hydrogen propellant gas at a supply pressure of 65 bar. Initially, deuterium pellets 7.5 mm in diameter and 11 mm in length were produced-the largest cryogenic pellets produced by the fusion program to date. These pellets represent about a 10% density perturbation to ITER. Subsequently, the extruder nozzle was modified to produce pellets that are almost 7.5-mm right circular cylinders. Tritium and D-T pellets have been produced in experiments at the Los Alamos National Laboratory Tritium Systems Test Assembly. About 38 g of tritium have been utilized in the experiment. The tritium was received in eight batches, six from product containers and two from the Isotope Separation System. Two types of runs were made: those in which the material was only extruded and those in which pellets were produced and fired with deuterium propellant. A total of 36 TZ runs and 28 D-T runs have been made. A total of 36 pure tritium runs and 28 D-T mixture runs were made. Extrusion experiments indicate that both T2 and D-T will require higher extrusion forces than D2 by about a factor of two.« less

Camping impact management on the Appalachian National Scenic Trail

USGS Publications Warehouse

Marion, J.L.

2003-01-01

This report addresses the management of overnight use and associated impacts along the Appalachian National Scenic Trail (A.T.). This effort was initiated in response to agency and Appalachian Trail Conference (ATC) management concerns regarding the resource and social impacts of increasing overnight visitation, particularly in high use areas. Report findings and recommendations are primarily based on series of on-site investigations at 17 problem areas selected by A.T. clubs and ATC staff. However, the report?s recommendations also draw on an examination of relevant A.T. legislative, agency, and organization guidance and visitor impact management knowledge derived from research and management experience.

Pressure Dependence Transport Studies of the Possible Charge Kondo Effect in Tl-doped PbTe

NASA Astrophysics Data System (ADS)

Kurosaki, Yosuke; Shinagawa, Jun; Matsushita, Yana; Geballe, Ted; Fisher, Ian; Brown, Stuart

2006-03-01

Pb1-xTlxTe is noteworthy for a high superconducting transition temperature relative to carrier concentration, as well as normal state properties consistent with a charge-Kondo effect. Recent experiments also demonstrate that the onset of an observable superconducting Tc with Tl concentration at x˜0.3% coincides with features characteristic of charge Kondo [1], including dρ/dT<0 at low temperatures and an unusual linear variation of the resistivity ρ(T)=ρ0+AT at higher temperatures. Together, these observations are consistent with an association between the two phenomena [2]. We report the effect of applied pressures up to P˜1.5GPa on ρ(T), Tc, and the Hall number pH≡RH-1 for x= 0.3%, 0.8%, and 1.3%. Tc is reduced sharply with pressure, dTc/dP=400-500mK/GPa as the low temperature Kondo- like upturn in ρ(T) is weakened. Also, dA/dP<0 and dpH/dP>0. These observations are discussed in the context of the proposed charge-Kondo model for Pb1-xTlxTe. [1] Y. Matsushita, H. Bluhm, T.H. Geballe and I.R. Fisher, Phys.Rev.Lett. 94, 157002(2005).[2] M. Dzero and J. Schmalian, Phys.Rev.Lett. 94, 157003 (2005). This work is supported by NSF frant DMR-0520552.

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

PubMed

Hu, Xinli; Kim, Hyun; Raj, Towfique; Brennan, Patrick J; Trynka, Gosia; Teslovich, Nikola; Slowikowski, Kamil; Chen, Wei-Min; Onengut, Suna; Baecher-Allan, Clare; De Jager, Philip L; Rich, Stephen S; Stranger, Barbara E; Brenner, Michael B; Raychaudhuri, Soumya

2014-06-01

Genome-wide association studies (GWAS) and subsequent dense-genotyping of associated loci identified over a hundred single-nucleotide polymorphism (SNP) variants associated with the risk of rheumatoid arthritis (RA), type 1 diabetes (T1D), and celiac disease (CeD). Immunological and genetic studies suggest a role for CD4-positive effector memory T (CD+ TEM) cells in the pathogenesis of these diseases. To elucidate mechanisms of autoimmune disease alleles, we investigated molecular phenotypes in CD4+ effector memory T cells potentially affected by these variants. In a cohort of genotyped healthy individuals, we isolated high purity CD4+ TEM cells from peripheral blood, then assayed relative abundance, proliferation upon T cell receptor (TCR) stimulation, and the transcription of 215 genes within disease loci before and after stimulation. We identified 46 genes regulated by cis-acting expression quantitative trait loci (eQTL), the majority of which we detected in stimulated cells. Eleven of the 46 genes with eQTLs were previously undetected in peripheral blood mononuclear cells. Of 96 risk alleles of RA, T1D, and/or CeD in densely genotyped loci, eleven overlapped cis-eQTLs, of which five alleles completely explained the respective signals. A non-coding variant, rs389862A, increased proliferative response (p=4.75 × 10-8). In addition, baseline expression of seventeen genes in resting cells reliably predicted proliferative response after TCR stimulation. Strikingly, however, there was no evidence that risk alleles modulated CD4+ TEM abundance or proliferation. Our study underscores the power of examining molecular phenotypes in relevant cells and conditions for understanding pathogenic mechanisms of disease variants.

Testing Lorentz and C P T invariance with ultracold neutrons

NASA Astrophysics Data System (ADS)

Martín-Ruiz, A.; Escobar, C. A.

2018-05-01

In this paper we investigate, within the standard model extension framework, the influence of Lorentz- and C P T -violating terms on gravitational quantum states of ultracold neutrons. Using a semiclassical wave packet, we derive the effective nonrelativistic Hamiltonian which describes the neutrons vertical motion by averaging the contributions from the perpendicular coordinates to the free falling axis. We compute the physical implications of the Lorentz- and C P T -violating terms on the spectra. The comparison of our results with those obtained in the GRANIT experiment leads to an upper bound for the symmetries-violation cμν n coefficients. We find that ultracold neutrons are sensitive to the ain and ein coefficients, which thus far are unbounded by experiments in the neutron sector. We propose two additional problems involving ultracold neutrons which could be relevant for improving our current bounds; namely, gravity-resonance spectroscopy and neutron whispering gallery wave.

Strategy for D/He-3 fusion development

NASA Technical Reports Server (NTRS)

Santarius, John F.

1988-01-01

It is concluded that Deuterium/Helium-3 fusion faces a more difficult physics development path but an easier technology development path than does Deuterium/Tritium. Early D/He-3 tests in next generation D/T fusion experiments might provide a valuable D/He-3 proof-of-principle at modest cost. At least one high leverage alternate concept should be vigorously pursued. Space applications of D/He-3 fusion are critically important to large scale development.

Source characterization and modeling development for monoenergetic-proton radiography experiments on OMEGA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manuel, M. J.-E.; Zylstra, A. B.; Rinderknecht, H. G.

2012-06-15

A monoenergetic proton source has been characterized and a modeling tool developed for proton radiography experiments at the OMEGA [T. R. Boehly et al., Opt. Comm. 133, 495 (1997)] laser facility. Multiple diagnostics were fielded to measure global isotropy levels in proton fluence and images of the proton source itself provided information on local uniformity relevant to proton radiography experiments. Global fluence uniformity was assessed by multiple yield diagnostics and deviations were calculated to be {approx}16% and {approx}26% of the mean for DD and D{sup 3}He fusion protons, respectively. From individual fluence images, it was found that the angular frequenciesmore » of Greater-Than-Or-Equivalent-To 50 rad{sup -1} contributed less than a few percent to local nonuniformity levels. A model was constructed using the Geant4 [S. Agostinelli et al., Nuc. Inst. Meth. A 506, 250 (2003)] framework to simulate proton radiography experiments. The simulation implements realistic source parameters and various target geometries. The model was benchmarked with the radiographs of cold-matter targets to within experimental accuracy. To validate the use of this code, the cold-matter approximation for the scattering of fusion protons in plasma is discussed using a typical laser-foil experiment as an example case. It is shown that an analytic cold-matter approximation is accurate to within Less-Than-Or-Equivalent-To 10% of the analytic plasma model in the example scenario.« less

Measurement of the inclusive forward-backward t$$\\bar{t}$$ production asymmetry and its rapidity dependence dA fb/d(Δy)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strycker, Glenn Loyd

2010-01-01

Early measurements of a large forward-background asymmetry at the CDF and D0 experiments at Fermilab have generated much recent interest, but were hampered by large uncertainties. We present here a new measurement of the parton level forward-backward asymmetry of pair-produced top quarks, using a high-statistics sample with much improved precision. We study the rapidity, y top, of the top quark production angle with respect to the incoming parton momentum in both the lab and tmore » $$\\bar{t}$$ rest frames. We find the parton-level forward-backward asymmetries to be A fb p$$\\bar{t}$$ = 0.150 ± 0.050 stat ± 0.024 syst A fb t$$\\bar{t}$$ = 0.158 ± 0.072{sup stat} ± 0.024 syst. These results should be compared with the small p$$\\bar{p}$$ frame charge asymmetry expected in QCD at NLO, A fb = 0.050 ± 0.015. Additionally, we introduce a measurement of the A fb rapidity dependence dA fb/d(Δy). We find this to be A fb p$$\\bar{t}$$(|Δy| < 1.0) = 0.026 ± 0.104 stat ± 0.012 syst A fb p$$\\bar{t}$$(|Δy| > 1.0) = 0.611 ± 0.210 stat ± 0.246 syst which we compare with model predictions 0.039 ± 0.006 and 0.123 ± 0.018 for the inner and outer rapidities, respectively.« less

Measurement of Prompt D0 Meson Azimuthal Anisotropy in Pb-Pb Collisions at √{sN N }=5.02 TeV

NASA Astrophysics Data System (ADS)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Grossmann, J.; Hrubec, J.; Jeitler, M.; König, A.; Krammer, N.; Krätschmer, I.; Liko, D.; Madlener, T.; Mikulec, I.; Pree, E.; Rabady, D.; Rad, N.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Spanring, M.; Spitzbart, D.; Waltenberger, W.; Wittmann, J.; Wulz, C.-E.; Zarucki, M.; Chekhovsky, V.; Mossolov, V.; Suarez Gonzalez, J.; De Wolf, E. A.; Di Croce, D.; Janssen, X.; Lauwers, J.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; De Bruyn, I.; De Clercq, J.; Deroover, K.; Flouris, G.; Lontkovskyi, D.; Lowette, S.; Moortgat, S.; Moreels, L.; Python, Q.; Skovpen, K.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Luetic, J.; Maerschalk, T.; Marinov, A.; Randle-conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Vannerom, D.; Yonamine, R.; Zenoni, F.; Zhang, F.; Cimmino, A.; Cornelis, T.; Dobur, D.; Fagot, A.; Gul, M.; Khvastunov, I.; Poyraz, D.; Roskas, C.; Salva, S.; Tytgat, M.; Verbeke, W.; Zaganidis, N.; Bakhshiansohi, H.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; De Visscher, S.; Delaere, C.; Delcourt, M.; Francois, B.; Giammanco, A.; Jafari, A.; Komm, M.; Krintiras, G.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Musich, M.; Piotrzkowski, K.; Quertenmont, L.; Vidal Marono, M.; Wertz, S.; Beliy, N.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hensel, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Melo De Almeida, M.; Mora Herrera, C.; Mundim, L.; Nogima, H.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Torres Da Silva De Araujo, F.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Misheva, M.; Rodozov, M.; Shopova, M.; Stoykova, S.; Sultanov, G.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Fang, W.; Gao, X.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Chen, Y.; Jiang, C. H.; Leggat, D.; Liao, H.; Liu, Z.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Yazgan, E.; Zhang, H.; Zhao, J.; Ban, Y.; Chen, G.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; González Hernández, C. F.; Ruiz Alvarez, J. D.; Courbon, B.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Sculac, T.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Ferencek, D.; Kadija, K.; Mesic, B.; Starodumov, A.; Susa, T.; Ather, M. W.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Finger, M.; Finger, M.; Carrera Jarrin, E.; El-khateeb, E.; Elgammal, S.; Ellithi Kamel, A.; Dewanjee, R. K.; Kadastik, M.; Perrini, L.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Järvinen, T.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Faure, J. L.; Ferri, F.; Ganjour, S.; Ghosh, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Kucher, I.; Locci, E.; Machet, M.; Malcles, J.; Negro, G.; Rander, J.; Rosowsky, A.; Sahin, M. Ö.; Titov, M.; Abdulsalam, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Charlot, C.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Lobanov, A.; Martin Blanco, J.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Stahl Leiton, A. G.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Zghiche, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Jansová, M.; Le Bihan, A.-C.; Tonon, N.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fay, J.; Finco, L.; Gascon, S.; Gouzevitch, M.; Grenier, G.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Popov, A.; Sordini, V.; Vander Donckt, M.; Viret, S.; Khvedelidze, A.; Bagaturia, I.; Autermann, C.; Beranek, S.; Feld, L.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Preuten, M.; Schomakers, C.; Schulz, J.; Verlage, T.; Albert, A.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hamer, M.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Merschmeyer, M.; Meyer, A.; Millet, P.; Mukherjee, S.; Olschewski, M.; Padeken, K.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Teyssier, D.; Thüer, S.; Flügge, G.; Kargoll, B.; Kress, T.; Künsken, A.; Lingemann, J.; Müller, T.; Nehrkorn, A.; Nowack, A.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Arndt, T.; Asawatangtrakuldee, C.; Beernaert, K.; Behnke, O.; Behrens, U.; Bermúdez Martínez, A.; Bin Anuar, A. A.; Borras, K.; Botta, V.; Campbell, A.; Connor, P.; Contreras-Campana, C.; Costanza, F.; Diez Pardos, C.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Eren, E.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Grados Luyando, J. M.; Grohsjean, A.; Gunnellini, P.; Harb, A.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Kasemann, M.; Keaveney, J.; Kleinwort, C.; Korol, I.; Krücker, D.; Lange, W.; Lelek, A.; Lenz, T.; Leonard, J.; Lipka, K.; Lohmann, W.; Mankel, R.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Ntomari, E.; Pitzl, D.; Raspereza, A.; Roland, B.; Savitskyi, M.; Saxena, P.; Shevchenko, R.; Spannagel, S.; Stefaniuk, N.; Van Onsem, G. P.; Walsh, R.; Wen, Y.; Wichmann, K.; Wissing, C.; Zenaiev, O.; Bein, S.; Blobel, V.; Centis Vignali, M.; Dreyer, T.; Garutti, E.; Gonzalez, D.; Haller, J.; Hinzmann, A.; Hoffmann, M.; Karavdina, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Kurz, S.; Lapsien, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Niedziela, M.; Nowatschin, D.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Scharf, C.; Schleper, P.; Schmidt, A.; Schumann, S.; Schwandt, J.; Sonneveld, J.; Stadie, H.; Steinbrück, G.; Stober, F. M.; Stöver, M.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Akbiyik, M.; Barth, C.; Baur, S.; Butz, E.; Caspart, R.; Chwalek, T.; Colombo, F.; De Boer, W.; Dierlamm, A.; Freund, B.; Friese, R.; Giffels, M.; Gilbert, A.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Kassel, F.; Kudella, S.; Mildner, H.; Mozer, M. U.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Schröder, M.; Shvetsov, I.; Sieber, G.; Simonis, H. J.; Ulrich, R.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Topsis-Giotis, I.; Karathanasis, G.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Evangelou, I.; Foudas, C.; Kokkas, P.; Mallios, S.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Triantis, F. 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M.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Errico, F.; Fiore, L.; Iaselli, G.; Lezki, S.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Sharma, A.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. 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T.; Ligabue, F.; Lomtadze, T.; Manca, E.; Mandorli, G.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Cipriani, M.; Daci, N.; Del Re, D.; Diemoz, M.; Gelli, S.; Longo, E.; Margaroli, F.; Marzocchi, B.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bartosik, N.; Bellan, R.; Biino, C.; Cartiglia, N.; Cenna, F.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Monteno, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Shchelina, K.; Sola, V.; Solano, A.; Staiano, A.; Traczyk, P.; Belforte, S.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Zanetti, A.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Lee, J.; Lee, S.; Lee, S. W.; Moon, C. S.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Lee, A.; Kim, H.; Moon, D. H.; Oh, G.; Brochero Cifuentes, J. A.; Goh, J.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Kim, J. S.; Lee, H.; Lee, K.; Nam, K.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Choi, Y.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Reyes-Almanza, R.; Ramirez-Sanchez, G.; Duran-Osuna, M. C.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Rabadan-Trejo, R. 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V.; Seixas, J.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Afanasiev, S.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Palichik, V.; Perelygin, V.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Voytishin, N.; Zarubin, A.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Levchenko, P.; Murzin, V.; Oreshkin, V.; Smirnov, I.; Sulimov, V.; Uvarov, L.; Vavilov, S.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Stepennov, A.; Toms, M.; Vlasov, E.; Zhokin, A.; Aushev, T.; Bylinkin, A.; Chadeeva, M.; Parygin, P.; Philippov, D.; Polikarpov, S.; Popova, E.; Rusinov, V.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Terkulov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Ershov, A.; Gribushin, A.; Kaminskiy, A.; Kodolova, O.; Korotkikh, V.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Vardanyan, I.; Blinov, V.; Skovpen, Y.; Shtol, D.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Elumakhov, D.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Cirkovic, P.; Devetak, D.; Dordevic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Barrio Luna, M.; Cerrada, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Álvarez Fernández, A.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Cuevas, J.; Erice, C.; Fernandez Menendez, J.; Gonzalez Caballero, I.; González Fernández, J. R.; Palencia Cortezon, E.; Sanchez Cruz, S.; Suárez Andrés, I.; Vischia, P.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Chazin Quero, B.; Curras, E.; Duarte Campderros, J.; Fernandez, M.; Garcia-Ferrero, J.; Gomez, G.; Lopez Virto, A.; Marco, J.; Martinez Rivero, C.; Martinez Ruiz del Arbol, P.; Matorras, F.; Piedra Gomez, J.; Rodrigo, T.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Baillon, P.; Ball, A. H.; Barney, D.; Bianco, M.; Bloch, P.; Bocci, A.; Botta, C.; Camporesi, T.; Castello, R.; Cepeda, M.; Cerminara, G.; Chapon, E.; Chen, Y.; d'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; De Gruttola, M.; De Roeck, A.; Di Marco, E.; Dobson, M.; Dorney, B.; du Pree, T.; Dünser, M.; Dupont, N.; Elliott-Peisert, A.; Everaerts, P.; Franzoni, G.; Fulcher, J.; Funk, W.; Gigi, D.; Gill, K.; Glege, F.; Gulhan, D.; Gundacker, S.; Guthoff, M.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Karacheban, O.; Kieseler, J.; Kirschenmann, H.; Knünz, V.; Kornmayer, A.; Kortelainen, M. J.; Krammer, M.; Lange, C.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Malgeri, L.; Mannelli, M.; Martelli, A.; Meijers, F.; Merlin, J. A.; Mersi, S.; Meschi, E.; Milenovic, P.; Moortgat, F.; Mulders, M.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Seidel, M.; Selvaggi, M.; Sharma, A.; Silva, P.; Sphicas, P.; Stakia, A.; Steggemann, J.; Stoye, M.; Tosi, M.; Treille, D.; Triossi, A.; Tsirou, A.; Veckalns, V.; Veres, G. I.; Verweij, M.; Wardle, N.; Zeuner, W. D.; Bertl, W.; Caminada, L.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Wiederkehr, S. A.; Bachmair, F.; Bäni, L.; Berger, P.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Klijnsma, T.; Lustermann, W.; Mangano, B.; Marionneau, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Reichmann, M.; Schönenberger, M.; Shchutska, L.; Tavolaro, V. R.; Theofilatos, K.; Vesterbacka Olsson, M. L.; Wallny, R.; Zhu, D. H.; Aarrestad, T. K.; Amsler, C.; Canelli, M. F.; De Cosa, A.; Del Burgo, R.; Donato, S.; Galloni, C.; Hreus, T.; Kilminster, B.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Seitz, C.; Takahashi, Y.; Zucchetta, A.; Candelise, V.; Doan, T. H.; Jain, Sh.; Khurana, R.; Kuo, C. M.; Lin, W.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chao, Y.; Chen, K. F.; Chen, P. H.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Paganis, E.; Psallidas, A.; Steen, A.; Tsai, J. f.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Adiguzel, A.; Boran, F.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. S.; Dozen, C.; Dumanoglu, I.; Girgis, S.; Gokbulut, G.; Guler, Y.; Hos, I.; Kangal, E. 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R.; Williams, T.; Auzinger, G.; Bainbridge, R.; Breeze, S.; Buchmuller, O.; Bundock, A.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; De Wit, A.; Della Negra, M.; Di Maria, R.; Elwood, A.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Lane, R.; Laner, C.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Matsushita, T.; Nash, J.; Nikitenko, A.; Palladino, V.; Pesaresi, M.; Raymond, D. M.; Richards, A.; Rose, A.; Scott, E.; Seez, C.; Shtipliyski, A.; Summers, S.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Winterbottom, D.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Smith, C.; Bartek, R.; Dominguez, A.; Buccilli, A.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Cutts, D.; Garabedian, A.; Hakala, J.; Heintz, U.; Hogan, J. M.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Pazzini, J.; Piperov, S.; Sagir, S.; Syarif, R.; Yu, D.; Band, R.; Brainerd, C.; Burns, D.; Calderon De La Barca Sanchez, M.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Gardner, M.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Shi, M.; Smith, J.; Squires, M.; Stolp, D.; Tos, K.; Tripathi, M.; Wang, Z.; Bachtis, M.; Bravo, C.; Cousins, R.; Dasgupta, A.; Florent, A.; Hauser, J.; Ignatenko, M.; Mccoll, N.; Saltzberg, D.; Schnaible, C.; Valuev, V.; Bouvier, E.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Ghiasi Shirazi, S. M. A.; Hanson, G.; Heilman, J.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Olmedo Negrete, M.; Paneva, M. I.; Shrinivas, A.; Si, W.; Wang, L.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Hashemi, B.; Holzner, A.; Klein, D.; Kole, G.; Krutelyov, V.; Letts, J.; Macneill, I.; Masciovecchio, M.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Amin, N.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Franco Sevilla, M.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Heller, R.; Incandela, J.; Mullin, S. D.; Ovcharova, A.; Qu, H.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Bendavid, J.; Bornheim, A.; Lawhorn, J. M.; Newman, H. B.; Nguyen, T.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhang, Z.; Zhu, R. Y.; Andrews, M. B.; Ferguson, T.; Mudholkar, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Weinberg, M.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Leontsinis, S.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; Mcdermott, K.; Mirman, N.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Abdullin, S.; Albrow, M.; Apollinari, G.; Apresyan, A.; Apyan, A.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Canepa, A.; Cerati, G. B.; Cheung, H. W. K.; Chlebana, F.; Cremonesi, M.; Duarte, J.; Elvira, V. D.; Freeman, J.; Gecse, Z.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Lincoln, D.; Lipton, R.; Liu, M.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Schneider, B.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strait, J.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Field, R. D.; Furic, I. K.; Konigsberg, J.; Korytov, A.; Kotov, K.; Ma, P.; Matchev, K.; Mei, H.; Mitselmakher, G.; Rank, D.; Sperka, D.; Terentyev, N.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Joshi, Y. R.; Linn, S.; Markowitz, P.; Rodriguez, J. L.; Ackert, A.; Adams, T.; Askew, A.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Kolberg, T.; Martinez, G.; Perry, T.; Prosper, H.; Saha, A.; Santra, A.; Yohay, R.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Cavanaugh, R.; Chen, X.; Evdokimov, O.; Gerber, C. E.; Hangal, D. A.; Hofman, D. J.; Jung, K.; Kamin, J.; Sandoval Gonzalez, I. D.; Tonjes, M. B.; Trauger, H.; Varelas, N.; Wang, H.; Wu, Z.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Castle, J.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Royon, C.; Sanders, S.; Schmitz, E.; Stringer, R.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Hadley, N. J.; Jabeen, S.; Jeng, G. Y.; Kellogg, R. G.; Kunkle, J.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Azzolini, V.; Barbieri, R.; Baty, A.; Bi, R.; Brandt, S.; Busza, W.; Cali, I. A.; D'Alfonso, M.; Demiragli, Z.; Gomez Ceballos, G.; Goncharov, M.; Hsu, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Maier, B.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Tatar, K.; Velicanu, D.; Wang, J.; Wang, T. W.; Wyslouch, B.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Hansen, P.; Kalafut, S.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Claes, D. R.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Kravchenko, I.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Alyari, M.; Dolen, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Nguyen, D.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wood, D.; Bhattacharya, S.; Charaf, O.; Hahn, K. A.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Dev, N.; Hildreth, M.; Hurtado Anampa, K.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Loukas, N.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Wayne, M.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Ji, W.; Liu, B.; Luo, W.; Puigh, D.; Winer, B. L.; Wulsin, H. W.; Benaglia, A.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Higginbotham, S.; Lange, D.; Luo, J.; Marlow, D.; Mei, K.; Ojalvo, I.; Olsen, J.; Palmer, C.; Piroué, P.; Stickland, D.; Tully, C.; Malik, S.; Norberg, S.; Barker, A.; Barnes, V. E.; Das, S.; Folgueras, S.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Khatiwada, A.; Miller, D. H.; Neumeister, N.; Peng, C. C.; Qiu, H.; Schulte, J. F.; Sun, J.; Wang, F.; Xie, W.; Cheng, T.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Ciesielski, R.; Goulianos, K.; Mesropian, C.; Agapitos, A.; Chou, J. P.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Kyriacou, S.; Lath, A.; Montalvo, R.; Nash, K.; Osherson, M.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Delannoy, A. G.; Foerster, M.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Castaneda Hernandez, A.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Damgov, J.; De Guio, F.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Hirosky, R.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Xia, F.; Harr, R.; Karchin, P. E.; Sturdy, J.; Zaleski, S.; Brodski, M.; Buchanan, J.; Caillol, C.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Hussain, U.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Pierro, G. A.; Polese, G.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; CMS Collaboration

2018-05-01

The prompt D0 meson azimuthal anisotropy coefficients, v2 and v3, are measured at midrapidity (|y |<1.0 ) in Pb-Pb collisions at a center-of-mass energy √{sN N }=5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (pT ) range of 1 to 40 GeV /c , for central and midcentral collisions. The v2 coefficient is found to be positive throughout the pT range studied. The first measurement of the prompt D0 meson v3 coefficient is performed, and values up to 0.07 are observed for pT around 4 GeV /c . Compared to measurements of charged particles, a similar pT dependence, but smaller magnitude for pT <6 GeV /c , is found for prompt D0 meson v2 and v3 coefficients. The results are consistent with the presence of collective motion of charm quarks at low pT and a path length dependence of charm quark energy loss at high pT , thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.

Measurement of Prompt D 0 Meson Azimuthal Anisotropy in Pb-Pb Collisions at s N N = 5.02 TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2018-05-16

The prompt D 0 meson azimuthal anisotropy coefficients, v 2 and v 3, are measured at midrapidity (|y|<1.0) in Pb-Pb collisions at a center-of-mass energymore » $$\\sqrt{{s}_{NN}}$$ = 5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (p T) range of 1 to 40 GeV/c, for central and midcentral collisions. The v 2 coefficient is found to be positive throughout the p T range studied. The first measurement of the prompt D 0 meson v 3 coefficient is performed, and values up to 0.07 are observed for p T around 4 GeV/c. Compared to measurements of charged particles, a similar p T dependence, but smaller magnitude for p T < 6 GeV/c, is found for prompt D 0 meson v 2 and v 3 coefficients. The results are consistent with the presence of collective motion of charm quarks at low p T and a path length dependence of charm quark energy loss at high p T, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.« less

Measurement of Prompt D^{0} Meson Azimuthal Anisotropy in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

PubMed

Sirunyan, A M; Tumasyan, A; Adam, W; Ambrogi, F; Asilar, E; Bergauer, T; Brandstetter, J; Brondolin, E; Dragicevic, M; Erö, J; Flechl, M; Friedl, M; Frühwirth, R; Ghete, V M; Grossmann, J; Hrubec, J; Jeitler, M; König, A; Krammer, N; Krätschmer, I; Liko, D; Madlener, T; Mikulec, I; Pree, E; Rabady, D; Rad, N; Rohringer, H; Schieck, J; Schöfbeck, R; Spanring, M; Spitzbart, D; Waltenberger, W; Wittmann, J; Wulz, C-E; Zarucki, M; Chekhovsky, V; Mossolov, V; Suarez Gonzalez, J; De Wolf, E A; Di Croce, D; Janssen, X; Lauwers, J; Van Haevermaet, H; Van Mechelen, P; Van Remortel, N; Abu Zeid, S; Blekman, F; D'Hondt, J; De Bruyn, I; De Clercq, J; Deroover, K; Flouris, G; Lontkovskyi, D; Lowette, S; Moortgat, S; Moreels, L; Python, Q; Skovpen, K; Tavernier, S; Van Doninck, W; Van Mulders, P; Van Parijs, I; Brun, H; Clerbaux, B; De Lentdecker, G; Delannoy, H; Fasanella, G; Favart, L; Goldouzian, R; Grebenyuk, A; Karapostoli, G; Lenzi, T; Luetic, J; Maerschalk, T; Marinov, A; Randle-Conde, A; Seva, T; 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Kunori, S; Lamichhane, K; Lee, S W; Libeiro, T; Peltola, T; Undleeb, S; Volobouev, I; Wang, Z; Greene, S; Gurrola, A; Janjam, R; Johns, W; Maguire, C; Melo, A; Ni, H; Sheldon, P; Tuo, S; Velkovska, J; Xu, Q; Arenton, M W; Barria, P; Cox, B; Hirosky, R; Ledovskoy, A; Li, H; Neu, C; Sinthuprasith, T; Sun, X; Wang, Y; Wolfe, E; Xia, F; Harr, R; Karchin, P E; Sturdy, J; Zaleski, S; Brodski, M; Buchanan, J; Caillol, C; Dasu, S; Dodd, L; Duric, S; Gomber, B; Grothe, M; Herndon, M; Hervé, A; Hussain, U; Klabbers, P; Lanaro, A; Levine, A; Long, K; Loveless, R; Pierro, G A; Polese, G; Ruggles, T; Savin, A; Smith, N; Smith, W H; Taylor, D; Woods, N

2018-05-18

The prompt D^{0} meson azimuthal anisotropy coefficients, v_{2} and v_{3}, are measured at midrapidity (|y|<1.0) in Pb-Pb collisions at a center-of-mass energy sqrt[s_{NN}]=5.02  TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (p_{T}) range of 1 to 40  GeV/c, for central and midcentral collisions. The v_{2} coefficient is found to be positive throughout the p_{T} range studied. The first measurement of the prompt D^{0} meson v_{3} coefficient is performed, and values up to 0.07 are observed for p_{T} around 4  GeV/c. Compared to measurements of charged particles, a similar p_{T} dependence, but smaller magnitude for p_{T}<6  GeV/c, is found for prompt D^{0} meson v_{2} and v_{3} coefficients. The results are consistent with the presence of collective motion of charm quarks at low p_{T} and a path length dependence of charm quark energy loss at high p_{T}, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.

Measurement of Prompt D 0 Meson Azimuthal Anisotropy in Pb-Pb Collisions at s N N = 5.02 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

The prompt D 0 meson azimuthal anisotropy coefficients, v 2 and v 3, are measured at midrapidity (|y|<1.0) in Pb-Pb collisions at a center-of-mass energymore » $$\\sqrt{{s}_{NN}}$$ = 5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (p T) range of 1 to 40 GeV/c, for central and midcentral collisions. The v 2 coefficient is found to be positive throughout the p T range studied. The first measurement of the prompt D 0 meson v 3 coefficient is performed, and values up to 0.07 are observed for p T around 4 GeV/c. Compared to measurements of charged particles, a similar p T dependence, but smaller magnitude for p T < 6 GeV/c, is found for prompt D 0 meson v 2 and v 3 coefficients. The results are consistent with the presence of collective motion of charm quarks at low p T and a path length dependence of charm quark energy loss at high p T, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.« less

Measurement of prompt $D^0$ meson azimuthal anisotropy in Pb-Pb collisions at $$\\sqrt{{s}_{NN}}$$ = 5.02 TeV

DOE PAGES

Sirunyan, Albert M; et al.

2018-05-17

The prompt D0 meson azimuthal anisotropy coefficients, v2 and v3, are measured at midrapidity (|y|<1.0) in Pb-Pb collisions at a center-of-mass energy sNN=5.02  TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (pT) range of 1 to 40  GeV/c, for central and midcentral collisions. The v2 coefficient is found to be positive throughout the pT range studied. The first measurement of the prompt D0 meson v3 coefficient is performed, and values up to 0.07 are observed for pT around 4  GeV/c. Compared to measurements of charged particles, a similar pT dependence, but smallermore » magnitude for pT<6  GeV/c, is found for prompt D0 meson v2 and v3 coefficients. The results are consistent with the presence of collective motion of charm quarks at low pT and a path length dependence of charm quark energy loss at high pT, thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.« less

Antioxidants may Attenuate Plasma Erythropoietin Decline after Hyperbaric Oxygen Diving.

PubMed

Mutzbauer, T S; Schneider, M; Neubauer, B; Weiss, M; Tetzlaff, K

2015-11-01

According to previous studies, plasma erythropoietin (EPO) may decrease after hyperbaric oxygen exposure due to oxidative stress. It is hypothesized that the decrease of EPO can be attenuated by oxygen free radical scavengers.The aim of the present study was to evaluate whether EPO plasma levels can be influenced by oral application of vitamin C and E before repeated hyperbaric oxygen exposure during diving. 16 healthy male police task force divers performed 3 morning dives on oxygen within a regular diving schedule on 3 consecutive days. They were randomized into either the placebo group or the vitamin group, receiving 1 g ascorbic acid and 600 IU D-α-tocopherol orally 60 min before the dive. Blood samples for EPO measurement were taken on days 1, 2, and 3 at T1, T3 and T5 60 min before and at T2, T4 and T6 60 min after each dive, respectively. A moderate decrease of EPO was observed beginning at T3 until T6 in the placebo group. The EPO concentrations in the vitamin group did not show relevant variations compared to baseline. Radical scavenging vitamins C and D may counteract hyperbaric oxygen related mechanisms reducing EPO production in hyperbaric oxygen exposure during diving. © Georg Thieme Verlag KG Stuttgart · New York.

Identifying the Parent Body of the Tagish Lake Meteorite and Characterizing its Internal Heating History and Surface Processes

NASA Technical Reports Server (NTRS)

Hiroi, Takahiro

2004-01-01

This short (1-year) funded research encompassed laboratory measurements of the Tagish Lake meteorite samples, experiments of simulated space weathering on them, and comparison with D, T, and P asteroids in reflectance spectrum. In spite of its limited funding and period, we have performed said experiments here at Brown University and at University of Tokyo. Some of the major results were reported at the Lunar and Planetary Science Conference held in Houston in March, 2004. The Tagish Lake meteorite shows a unique visible reflectance spectrum identical to that of the D and T type asteroids. After the present heating experiments at even the lowest temperature of 100 C, the characteristic spectral slope of the Tagish Lake meteorite sample increased. On the other hand, after irradiating its pellet sample with pulse laser, the slope decreased. As the result, the Tagish Lake meteorite and its processed samples have come to cover a wide range of visible reflectance spectra in slope from the C-type asteroids to some extreme T/D-type asteroids, including the P-type asteroids in between. Therefore, logically speaking, our initial affirmation that the Tagish Lake meteorite must have come from one of the D-type asteroids can be wrong if such a meteoritic material is hidden under a space-weathered surface regolith of a C-type asteroid. However, such a case is likely to have a small probability in general. Other major hits of this research includes the first spectral fitting of the P-type asteroids using reflectance spectra derived from the present research. This topic needs more experiments and analysis to be addressed uniquely, and thus further efforts will be proposed.

R&D comes to services. Bank of America's pathbreaking experiments.

PubMed

Thomke, Stefan

2003-04-01

At the heart of business today lies a dilemma: Our economy is increasingly dependent on services, yet our innovation processes remain oriented toward products. Indeed, we have well-tested, scientific methods for developing and refining manufactured goods, but many of them don't seem applicable to the world of services. In this article, Harvard Business School professor Stefan Thomke points out the challenges of applying the discipline of formal R&D processes to services: Because a service often exists only in the moment of its delivery to a customer, it is difficult to isolate in a traditional laboratory. And since many services are tailored to individual buyers at the point of purchase, they can't be tested through large samples. As a result, experiments with new services are most useful when they are conducted live--with real customers engaged in real transactions. But live tests magnify the cost of failure; an experiment that doesn't work may harm customer relationships and even the brand. Given such challenges, it's no surprise that most service companies have not established rigorous, ongoing R&D processes, Thomke says. Here the author provides an in-depth look at a five-step process that Bank of America has used to create new service concepts for retail banking. The company has turned a set of its branches into, in effect, a laboratory where a corporate research team conducts service experiments with actual customers during regular business hours, compares results with those of control branches, and pinpoints attractive innovations for broader rollout. The author describes the program's workings, its successes, and the obstacles the bank faced. The effort reveals what a true R&D operation might look like inside a service business, he concludes.

Intersystem Crossing Pathways in the Noncanonical Nucleobase 2-Thiouracil: A Time-Dependent Picture

PubMed Central

2016-01-01

The deactivation mechanism after ultraviolet irradiation of 2-thiouracil has been investigated using nonadiabatic dynamics simulations at the MS-CASPT2 level of theory. It is found that after excitation the S2 quickly relaxes to S1, and from there intersystem crossing takes place to both T2 and T1 with a time constant of 400 fs and a triplet yield above 80%, in very good agreement with recent femtosecond experiments in solution. Both indirect S1 → T2 → T1 and direct S1 → T1 pathways contribute to intersystem crossing, with the former being predominant. The results contribute to the understanding of how some noncanonical nucleobases respond to harmful ultraviolet light, which could be relevant for prospective photochemotherapeutic applications. PMID:27167106

Rational design of hypoallergens applied to the major cat allergen Fel d 1.

PubMed

Saarne, T; Kaiser, L; Grönlund, H; Rasool, O; Gafvelin, G; van Hage-Hamsten, M

2005-05-01

Allergen-specific immunotherapy is the only treatment for allergic disease providing long-lasting symptom relief. Currently, it is mainly based on the use of crude allergen extracts. The treatment may be improved by the use of genetically engineered allergens, hypoallergens, aiming at a more effective and safer therapy. The aim of this study was to provide a rational design of hypoallergen candidates for immunotherapy by using structural information and knowledge of B and T cell epitopes of an allergen. The three-dimensional structure of the major cat allergen Fel d 1 was systematically altered by duplication of selected T cell epitopes and disruption of disulphide bonds. Seven Fel d 1 derivatives were generated and screened for allergenic reactivity in comparison with recombinant Fel d 1 in competition-ELISA. The allergenicity was further evaluated in basophil activation experiments and T cell reactivity was assessed in a lymphoproliferation assay. Three out of seven Fel d 1 derivatives, with two duplicated T cell epitopes and one or two disulphide bonds disrupted, were carefully evaluated. The three derivatives displayed a strong reduction in allergenicity with 400-900 times lower IgE-binding capacity than recombinant Fel d 1. In addition, they induced a lower degree of basophil activation and similar or stronger T cell proliferation than recombinant Fel d 1. By a rational approach, we have constructed three Fel d 1 hypoallergens with reduced IgE-binding capacities and retained T cell reactivities. This strategy may be applied to any well-characterized allergen to improve immunotherapy for allergic patients.

Overview of the JET results in support to ITER

NASA Astrophysics Data System (ADS)

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A.; Cobalt, A.; Coccorese, V.; Cocilovo, V.; Coda, S.; Coelho, R.; Coenen, J. W.; Coffey, I.; Colas, L.; Collins, S.; Conka, D.; Conroy, S.; Conway, N.; Coombs, D.; Cooper, D.; Cooper, S. R.; Corradino, C.; Corre, Y.; Corrigan, G.; Cortes, S.; Coster, D.; Couchman, A. S.; Cox, M. P.; Craciunescu, T.; Cramp, S.; Craven, R.; Crisanti, F.; Croci, G.; Croft, D.; Crombé, K.; Crowe, R.; Cruz, N.; Cseh, G.; Cufar, A.; Cullen, A.; Curuia, M.; Czarnecka, A.; Dabirikhah, H.; Dalgliesh, P.; Dalley, S.; Dankowski, J.; Darrow, D.; Davies, O.; Davis, W.; Day, C.; Day, I. E.; De Bock, M.; de Castro, A.; de la Cal, E.; de la Luna, E.; De Masi, G.; de Pablos, J. L.; De Temmerman, G.; De Tommasi, G.; de Vries, P.; Deakin, K.; Deane, J.; Degli Agostini, F.; Dejarnac, R.; Delabie, E.; den Harder, N.; Dendy, R. O.; Denis, J.; Denner, P.; Devaux, S.; Devynck, P.; Di Maio, F.; Di Siena, A.; Di Troia, C.; Dinca, P.; D'Inca, R.; Ding, B.; Dittmar, T.; Doerk, H.; Doerner, R. P.; Donné, T.; Dorling, S. E.; Dormido-Canto, S.; Doswon, S.; Douai, D.; Doyle, P. T.; Drenik, A.; Drewelow, P.; Drews, P.; Duckworth, Ph.; Dumont, R.; Dumortier, P.; Dunai, D.; Dunne, M.; Ďuran, I.; Durodié, F.; Dutta, P.; Duval, B. P.; Dux, R.; Dylst, K.; Dzysiuk, N.; Edappala, P. V.; Edmond, J.; Edwards, A. M.; Edwards, J.; Eich, Th.; Ekedahl, A.; El-Jorf, R.; Elsmore, C. G.; Enachescu, M.; Ericsson, G.; Eriksson, F.; Eriksson, J.; Eriksson, L. G.; Esposito, B.; Esquembri, S.; Esser, H. G.; Esteve, D.; Evans, B.; Evans, G. E.; Evison, G.; Ewart, G. D.; Fagan, D.; Faitsch, M.; Falie, D.; Fanni, A.; Fasoli, A.; Faustin, J. M.; Fawlk, N.; Fazendeiro, L.; Fedorczak, N.; Felton, R. C.; Fenton, K.; Fernades, A.; Fernandes, H.; Ferreira, J.; Fessey, J. A.; Février, O.; Ficker, O.; Field, A.; Fietz, S.; Figueiredo, A.; Figueiredo, J.; Fil, A.; Finburg, P.; Firdaouss, M.; Fischer, U.; Fittill, L.; Fitzgerald, M.; Flammini, D.; Flanagan, J.; Fleming, C.; Flinders, K.; Fonnesu, N.; Fontdecaba, J. M.; Formisano, A.; Forsythe, L.; Fortuna, L.; Fortuna-Zalesna, E.; Fortune, M.; Foster, S.; Franke, T.; Franklin, T.; Frasca, M.; Frassinetti, L.; Freisinger, M.; Fresa, R.; Frigione, D.; Fuchs, V.; Fuller, D.; Futatani, S.; Fyvie, J.; Gál, K.; Galassi, D.; Gałązka, K.; Galdon-Quiroga, J.; Gallagher, J.; Gallart, D.; Galvão, R.; Gao, X.; Gao, Y.; Garcia, J.; Garcia-Carrasco, A.; García-Muñoz, M.; Gardarein, J.-L.; Garzotti, L.; Gaudio, P.; Gauthier, E.; Gear, D. F.; Gee, S. J.; Geiger, B.; Gelfusa, M.; Gerasimov, S.; Gervasini, G.; Gethins, M.; Ghani, Z.; Ghate, M.; Gherendi, M.; Giacalone, J. C.; Giacomelli, L.; Gibson, C. S.; Giegerich, T.; Gil, C.; Gil, L.; Gilligan, S.; Gin, D.; Giovannozzi, E.; Girardo, J. B.; Giroud, C.; Giruzzi, G.; Glöggler, S.; Godwin, J.; Goff, J.; Gohil, P.; Goloborod'ko, V.; Gomes, R.; Gonçalves, B.; Goniche, M.; Goodliffe, M.; Goodyear, A.; Gorini, G.; Gosk, M.; Goulding, R.; Goussarov, A.; Gowland, R.; Graham, B.; Graham, M. E.; Graves, J. P.; Grazier, N.; Grazier, P.; Green, N. R.; Greuner, H.; Grierson, B.; Griph, F. S.; Grisolia, C.; Grist, D.; Groth, M.; Grove, R.; Grundy, C. N.; Grzonka, J.; Guard, D.; Guérard, C.; Guillemaut, C.; Guirlet, R.; Gurl, C.; Utoh, H. H.; Hackett, L. J.; Hacquin, S.; Hagar, A.; Hager, R.; Hakola, A.; Halitovs, M.; Hall, S. J.; Hallworth Cook, S. P.; Hamlyn-Harris, C.; Hammond, K.; Harrington, C.; Harrison, J.; Harting, D.; Hasenbeck, F.; Hatano, Y.; Hatch, D. R.; Haupt, T. D. V.; Hawes, J.; Hawkes, N. C.; Hawkins, J.; Hawkins, P.; Haydon, P. W.; Hayter, N.; Hazel, S.; Heesterman, P. J. L.; Heinola, K.; Hellesen, C.; Hellsten, T.; Helou, W.; Hemming, O. N.; Hender, T. C.; Henderson, M.; Henderson, S. S.; Henriques, R.; Hepple, D.; Hermon, G.; Hertout, P.; Hidalgo, C.; Highcock, E. G.; Hill, M.; Hillairet, J.; Hillesheim, J.; Hillis, D.; Hizanidis, K.; Hjalmarsson, A.; Hobirk, J.; Hodille, E.; Hogben, C. H. A.; Hogeweij, G. M. D.; Hollingsworth, A.; Hollis, S.; Homfray, D. A.; Horáček, J.; Hornung, G.; Horton, A. R.; Horton, L. D.; Horvath, L.; Hotchin, S. P.; Hough, M. R.; Howarth, P. J.; Hubbard, A.; Huber, A.; Huber, V.; Huddleston, T. M.; Hughes, M.; Huijsmans, G. T. A.; Hunter, C. L.; Huynh, P.; Hynes, A. M.; Iglesias, D.; Imazawa, N.; Imbeaux, F.; Imríšek, M.; Incelli, M.; Innocente, P.; Irishkin, M.; Ivanova-Stanik, I.; Jachmich, S.; Jacobsen, A. S.; Jacquet, P.; Jansons, J.; Jardin, A.; Järvinen, A.; Jaulmes, F.; Jednoróg, S.; Jenkins, I.; Jeong, C.; Jepu, I.; Joffrin, E.; Johnson, R.; Johnson, T.; Johnston, Jane; Joita, L.; Jones, G.; Jones, T. T. C.; Hoshino, K. K.; Kallenbach, A.; Kamiya, K.; Kaniewski, J.; Kantor, A.; Kappatou, A.; Karhunen, J.; Karkinsky, D.; Karnowska, I.; Kaufman, M.; Kaveney, G.; Kazakov, Y.; Kazantzidis, V.; Keeling, D. L.; Keenan, T.; Keep, J.; Kempenaars, M.; Kennedy, C.; Kenny, D.; Kent, J.; Kent, O. N.; Khilkevich, E.; Kim, H. T.; Kim, H. S.; Kinch, A.; king, C.; King, D.; King, R. F.; Kinna, D. J.; Kiptily, V.; Kirk, A.; Kirov, K.; Kirschner, A.; Kizane, G.; Klepper, C.; Klix, A.; Knight, P.; Knipe, S. J.; Knott, S.; Kobuchi, T.; Köchl, F.; Kocsis, G.; Kodeli, I.; Kogan, L.; Kogut, D.; Koivuranta, S.; Kominis, Y.; Köppen, M.; Kos, B.; Koskela, T.; Koslowski, H. R.; Koubiti, M.; Kovari, M.; Kowalska-Strzęciwilk, E.; Krasilnikov, A.; Krasilnikov, V.; Krawczyk, N.; Kresina, M.; Krieger, K.; Krivska, A.; Kruezi, U.; Książek, I.; Kukushkin, A.; Kundu, A.; Kurki-Suonio, T.; Kwak, S.; Kwiatkowski, R.; Kwon, O. J.; Laguardia, L.; Lahtinen, A.; Laing, A.; Lam, N.; Lambertz, H. T.; Lane, C.; Lang, P. T.; Lanthaler, S.; Lapins, J.; Lasa, A.; Last, J. R.; Łaszyńska, E.; Lawless, R.; Lawson, A.; Lawson, K. D.; Lazaros, A.; Lazzaro, E.; Leddy, J.; Lee, S.; Lefebvre, X.; Leggate, H. J.; Lehmann, J.; Lehnen, M.; Leichtle, D.; Leichuer, P.; Leipold, F.; Lengar, I.; Lennholm, M.; Lerche, E.; Lescinskis, A.; Lesnoj, S.; Letellier, E.; Leyland, M.; Leysen, W.; Li, L.; Liang, Y.; Likonen, J.; Linke, J.; Linsmeier, Ch.; Lipschultz, B.; Liu, G.; Liu, Y.; Lo Schiavo, V. P.; Loarer, T.; Loarte, A.; Lobel, R. C.; Lomanowski, B.; Lomas, P. J.; Lönnroth, J.; López, J. M.; López-Razola, J.; Lorenzini, R.; Losada, U.; Lovell, J. J.; Loving, A. B.; Lowry, C.; Luce, T.; Lucock, R. M. A.; Lukin, A.; Luna, C.; Lungaroni, M.; Lungu, C. P.; Lungu, M.; Lunniss, A.; Lupelli, I.; Lyssoivan, A.; Macdonald, N.; Macheta, P.; Maczewa, K.; Magesh, B.; Maget, P.; Maggi, C.; Maier, H.; Mailloux, J.; Makkonen, T.; Makwana, R.; Malaquias, A.; Malizia, A.; Manas, P.; Manning, A.; Manso, M. E.; Mantica, P.; Mantsinen, M.; Manzanares, A.; Maquet, Ph.; Marandet, Y.; Marcenko, N.; Marchetto, C.; Marchuk, O.; Marinelli, M.; Marinucci, M.; Markovič, T.; Marocco, D.; Marot, L.; Marren, C. A.; Marshal, R.; Martin, A.; Martin, Y.; Martín de Aguilera, A.; Martínez, F. J.; Martín-Solís, J. R.; Martynova, Y.; Maruyama, S.; Masiello, A.; Maslov, M.; Matejcik, S.; Mattei, M.; Matthews, G. F.; Maviglia, F.; Mayer, M.; Mayoral, M. L.; May-Smith, T.; Mazon, D.; Mazzotta, C.; McAdams, R.; McCarthy, P. J.; McClements, K. G.; McCormack, O.; McCullen, P. A.; McDonald, D.; McIntosh, S.; McKean, R.; McKehon, J.; Meadows, R. C.; Meakins, A.; Medina, F.; Medland, M.; Medley, S.; Meigh, S.; Meigs, A. G.; Meisl, G.; Meitner, S.; Meneses, L.; Menmuir, S.; Mergia, K.; Merrigan, I. R.; Mertens, Ph.; Meshchaninov, S.; Messiaen, A.; Meyer, H.; Mianowski, S.; Michling, R.; Middleton-Gear, D.; Miettunen, J.; Militello, F.; Militello-Asp, E.; Miloshevsky, G.; Mink, F.; Minucci, S.; Miyoshi, Y.; Mlynář, J.; Molina, D.; Monakhov, I.; Moneti, M.; Mooney, R.; Moradi, S.; Mordijck, S.; Moreira, L.; Moreno, R.; Moro, F.; Morris, A. W.; Morris, J.; Moser, L.; Mosher, S.; Moulton, D.; Murari, A.; Muraro, A.; Murphy, S.; Asakura, N. N.; Na, Y. S.; Nabais, F.; Naish, R.; Nakano, T.; Nardon, E.; Naulin, V.; Nave, M. F. F.; Nedzelski, I.; Nemtsev, G.; Nespoli, F.; Neto, A.; Neu, R.; Neverov, V. S.; Newman, M.; Nicholls, K. J.; Nicolas, T.; Nielsen, A. H.; Nielsen, P.; Nilsson, E.; Nishijima, D.; Noble, C.; Nocente, M.; Nodwell, D.; Nordlund, K.; Nordman, H.; Nouailletas, R.; Nunes, I.; Oberkofler, M.; Odupitan, T.; Ogawa, M. T.; O'Gorman, T.; Okabayashi, M.; Olney, R.; Omolayo, O.; O'Mullane, M.; Ongena, J.; Orsitto, F.; Orszagh, J.; Oswuigwe, B. I.; Otin, R.; Owen, A.; Paccagnella, R.; Pace, N.; Pacella, D.; Packer, L. W.; Page, A.; Pajuste, E.; Palazzo, S.; Pamela, S.; Panja, S.; Papp, P.; Paprok, R.; Parail, V.; Park, M.; Parra Diaz, F.; Parsons, M.; Pasqualotto, R.; Patel, A.; Pathak, S.; Paton, D.; Patten, H.; Pau, A.; Pawelec, E.; Soldan, C. Paz; Peackoc, A.; Pearson, I. J.; Pehkonen, S.-P.; Peluso, E.; Penot, C.; Pereira, A.; Pereira, R.; Pereira Puglia, P. P.; Perez von Thun, C.; Peruzzo, S.; Peschanyi, S.; Peterka, M.; Petersson, P.; Petravich, G.; Petre, A.; Petrella, N.; Petržilka, V.; Peysson, Y.; Pfefferlé, D.; Philipps, V.; Pillon, M.; Pintsuk, G.; Piovesan, P.; Pires dos Reis, A.; Piron, L.; Pironti, A.; Pisano, F.; Pitts, R.; Pizzo, F.; Plyusnin, V.; Pomaro, N.; Pompilian, O. G.; Pool, P. J.; Popovichev, S.; Porfiri, M. T.; Porosnicu, C.; Porton, M.; Possnert, G.; Potzel, S.; Powell, T.; Pozzi, J.; Prajapati, V.; Prakash, R.; Prestopino, G.; Price, D.; Price, M.; Price, R.; Prior, P.; Proudfoot, R.; Pucella, G.; Puglia, P.; Puiatti, M. E.; Pulley, D.; Purahoo, K.; Pütterich, Th.; Rachlew, E.; Rack, M.; Ragona, R.; Rainford, M. S. J.; Rakha, A.; Ramogida, G.; Ranjan, S.; Rapson, C. J.; Rasmussen, J. J.; Rathod, K.; Rattá, G.; Ratynskaia, S.; Ravera, G.; Rayner, C.; Rebai, M.; Reece, D.; Reed, A.; Réfy, D.; Regan, B.; Regaña, J.; Reich, M.; Reid, N.; Reimold, F.; Reinhart, M.; Reinke, M.; Reiser, D.; Rendell, D.; Reux, C.; Reyes Cortes, S. D. A.; Reynolds, S.; Riccardo, V.; Richardson, N.; Riddle, K.; Rigamonti, D.; Rimini, F. G.; Risner, J.; Riva, M.; Roach, C.; Robins, R. J.; Robinson, S. A.; Robinson, T.; Robson, D. W.; Roccella, R.; Rodionov, R.; Rodrigues, P.; Rodriguez, J.; Rohde, V.; Romanelli, F.; Romanelli, M.; Romanelli, S.; Romazanov, J.; Rowe, S.; Rubel, M.; Rubinacci, G.; Rubino, G.; Ruchko, L.; Ruiz, M.; Ruset, C.; Rzadkiewicz, J.; Saarelma, S.; Sabot, R.; Safi, E.; Sagar, P.; Saibene, G.; Saint-Laurent, F.; Salewski, M.; Salmi, A.; Salmon, R.; Salzedas, F.; Samaddar, D.; Samm, U.; Sandiford, D.; Santa, P.; Santala, M. I. K.; Santos, B.; Santucci, A.; Sartori, F.; Sartori, R.; Sauter, O.; Scannell, R.; Schlummer, T.; Schmid, K.; Schmidt, V.; Schmuck, S.; Schneider, M.; Schöpf, K.; Schwörer, D.; Scott, S. D.; Sergienko, G.; Sertoli, M.; Shabbir, A.; Sharapov, S. E.; Shaw, A.; Shaw, R.; Sheikh, H.; Shepherd, A.; Shevelev, A.; Shumack, A.; Sias, G.; Sibbald, M.; Sieglin, B.; Silburn, S.; Silva, A.; Silva, C.; Simmons, P. A.; Simpson, J.; Simpson-Hutchinson, J.; Sinha, A.; Sipilä, S. K.; Sips, A. C. C.; Sirén, P.; Sirinelli, A.; Sjöstrand, H.; Skiba, M.; Skilton, R.; Slabkowska, K.; Slade, B.; Smith, N.; Smith, P. G.; Smith, R.; Smith, T. J.; Smithies, M.; Snoj, L.; Soare, S.; Solano, E. R.; Somers, A.; Sommariva, C.; Sonato, P.; Sopplesa, A.; Sousa, J.; Sozzi, C.; Spagnolo, S.; Spelzini, T.; Spineanu, F.; Stables, G.; Stamatelatos, I.; Stamp, M. F.; Staniec, P.; Stankūnas, G.; Stan-Sion, C.; Stead, M. J.; Stefanikova, E.; Stepanov, I.; Stephen, A. V.; Stephen, M.; Stevens, A.; Stevens, B. D.; Strachan, J.; Strand, P.; Strauss, H. R.; Ström, P.; Stubbs, G.; Studholme, W.; Subba, F.; Summers, H. P.; Svensson, J.; Świderski, Ł.; Szabolics, T.; Szawlowski, M.; Szepesi, G.; Suzuki, T. T.; Tál, B.; Tala, T.; Talbot, A. R.; Talebzadeh, S.; Taliercio, C.; Tamain, P.; Tame, C.; Tang, W.; Tardocchi, M.; Taroni, L.; Taylor, D.; Taylor, K. A.; Tegnered, D.; Telesca, G.; Teplova, N.; Terranova, D.; Testa, D.; Tholerus, E.; Thomas, J.; Thomas, J. D.; Thomas, P.; Thompson, A.; Thompson, C.-A.; Thompson, V. K.; Thorne, L.; Thornton, A.; Thrysøe, A. S.; Tigwell, P. A.; Tipton, N.; Tiseanu, I.; Tojo, H.; Tokitani, M.; Tolias, P.; Tomeš, M.; Tonner, P.; Towndrow, M.; Trimble, P.; Tripsky, M.; Tsalas, M.; Tsavalas, P.; Tskhakaya jun, D.; Turner, I.; Turner, M. M.; Turnyanskiy, M.; Tvalashvili, G.; Tyrrell, S. G. J.; Uccello, A.; Ul-Abidin, Z.; Uljanovs, J.; Ulyatt, D.; Urano, H.; Uytdenhouwen, I.; Vadgama, A. P.; Valcarcel, D.; Valentinuzzi, M.; Valisa, M.; Vallejos Olivares, P.; Valovic, M.; Van De Mortel, M.; Van Eester, D.; Van Renterghem, W.; van Rooij, G. J.; Varje, J.; Varoutis, S.; Vartanian, S.; Vasava, K.; Vasilopoulou, T.; Vega, J.; Verdoolaege, G.; Verhoeven, R.; Verona, C.; Verona Rinati, G.; Veshchev, E.; Vianello, N.; Vicente, J.; Viezzer, E.; Villari, S.; Villone, F.; Vincenzi, P.; Vinyar, I.; Viola, B.; Vitins, A.; Vizvary, Z.; Vlad, M.; Voitsekhovitch, I.; Vondráček, P.; Vora, N.; Vu, T.; Pires de Sa, W. W.; Wakeling, B.; Waldon, C. W. F.; Walkden, N.; Walker, M.; Walker, R.; Walsh, M.; Wang, E.; Wang, N.; Warder, S.; Warren, R. J.; Waterhouse, J.; Watkins, N. W.; Watts, C.; Wauters, T.; Weckmann, A.; Weiland, J.; Weisen, H.; Weiszflog, M.; Wellstood, C.; West, A. T.; Wheatley, M. R.; Whetham, S.; Whitehead, A. M.; Whitehead, B. D.; Widdowson, A. M.; Wiesen, S.; Wilkinson, J.; Williams, J.; Williams, M.; Wilson, A. R.; Wilson, D. J.; Wilson, H. R.; Wilson, J.; Wischmeier, M.; Withenshaw, G.; Withycombe, A.; Witts, D. M.; Wood, D.; Wood, R.; Woodley, C.; Wray, S.; Wright, J.; Wright, J. C.; Wu, J.; Wukitch, S.; Wynn, A.; Xu, T.; Yadikin, D.; Yanling, W.; Yao, L.; Yavorskij, V.; Yoo, M. G.; Young, C.; Young, D.; Young, I. D.; Young, R.; Zacks, J.; Zagorski, R.; Zaitsev, F. S.; Zanino, R.; Zarins, A.; Zastrow, K. D.; Zerbini, M.; Zhang, W.; Zhou, Y.; Zilli, E.; Zoita, V.; Zoletnik, S.; Zychor, I.; JET Contributors

2017-10-01

The 2014-2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its installation in 2011. New multi-machine scaling of the type I-ELM divertor energy flux density to ITER is supported by first principle modelling. ITER relevant disruption experiments and first principle modelling are reported with a set of three disruption mitigation valves mimicking the ITER setup. Insights of the L-H power threshold in Deuterium and Hydrogen are given, stressing the importance of the magnetic configurations and the recent measurements of fine-scale structures in the edge radial electric. Dimensionless scans of the core and pedestal confinement provide new information to elucidate the importance of the first wall material on the fusion performance. H-mode plasmas at ITER triangularity (H  =  1 at β N ~ 1.8 and n/n GW ~ 0.6) have been sustained at 2 MA during 5 s. The ITER neutronics codes have been validated on high performance experiments. Prospects for the coming D-T campaign and 14 MeV neutron calibration strategy are reviewed.

Production and Applications of Long-Lived Positron-Emitting Radionuclides

NASA Astrophysics Data System (ADS)

Graves, Stephen A.

Positron emission tomography (PET) is a medical imaging modality capable of determining the in vivo spatial distribution of a biologically relevant molecule which has been labeled with a positron-emitting isotope. The use of molecules such as monoclonal antibodies and nanoparticles for therapeutic and diagnostic applications has expanded preclinically in recent years. As these larger molecules tend to have longer circulation times and slow clearance kinetics, positron-emitting isotopes with half-lives longer than conventional medical radioisotopes are required for PET applications. This dissertation details methods for the production of 51Mn (t1/2: 45.4 min), 52gMn (t1/2: 5.59 d), 64Cu (t1/2: 12.7 h), 76Br (t1/2: 16.2 h), 89Zr (t1/2: 3.27 d), and 194Au (t1/2: 38.0 h) on low-energy medical cyclotrons, including targetry considerations, radiochemical separation methods, and analysis of resulting purity. Pursuant to the production of these isotopes, several instrumentation developments have been made including implementation of an automatic nuclide identification library for gamma spectroscopy; development of methods for dead time correction and background estimation in auto-gamma counting; and the creation of a new linearly-filled Derenzo-type PET phantom. Measurement of the radioactive half-lives of 51Mn and 52gMn are presented in addition to their use in a variety of preclinical molecular imaging applications, including immunoPET, stem cell tracking, functional beta-cell mass determination, and probing the impact of isoflurane on acute pancreatic function. An analytic model of effective specific activity is formed and tested against preliminary trace metal analysis results. Measurements of excitation functions for the large-scale production of medically relevant isotopes, including 52gMn, at the Los Alamos National Laboratory Isotope Production Facility (100 MeV p+) are presented. The results described herein have enabled and informed a variety of novel investigations in the fields of nuclear medicine and molecular imaging.

Diagnostic et traitement du prurit

PubMed Central

Nowak, Dominik; Yeung, Jensen

2017-01-01

Résumé Objectif Décrire une approche permettant une évaluation simplifiée et une différenciation précise des démangeaisons chez la plupart des patients dans les soins de première ligne, et offrir une mise à jour sur les traitements non pharmacologiques, topiques et systémiques à notre disposition. Sources d’information Une recherche a été effectuée dans MEDLINE (Ovid) et PubMed, à l’aide des mots-clés anglais itch ou pruritus. Pour chaque cause et chaque traitement relevé, la recherche a été affinée en ajoutant les mots-clés appropriés, et des recherches subséquentes ont été effectuées à la main dans les références des articles relevés. Message principal Il n’existe pas de bonnes données cumulées tirées d’essais de bonne qualité sur le traitement du prurit, et les traitements qui existent donnent des résultats variables. Les principales causes des démangeaisons généralisées sont la xérose et l’eczéma. Le problème se résorbe, dans la plupart des cas, à l’aide de traitements non pharmacologiques, y compris l’hydratation fréquente. En cas d’échec, des investigations plus poussées sont justifiées pour orienter le traitement subséquent à l’aide de l’une des nombreuses approches topiques et systémiques spécifiques à la cause qui sont disponibles. Conclusion Les démangeaisons chroniques peuvent être incapacitantes pour les patients. L’approche dont il est question ici permet de simplifier l’évaluation et de différencier de manière précise la plupart des démangeaisons dans les soins de première ligne. PMID:29237631

Thin Slices of Athletes' Nonverbal Behavior Give Away Game Location: Testing the Territoriality Hypothesis of the Home Game Advantage.

PubMed

Furley, Philip; Schweizer, Geoffrey; Memmert, Daniel

2018-01-01

The present research investigated whether perceivers could detect who is playing at home or away in soccer matches based on thin slices of professional (Experiment 1) and amateur (Experiment 3) athletes' nonverbal behavior prior to the match and whether perceivers rated athletes playing at home relatively higher on behavioral dimensions (Experiments 2 and 3) linked to territoriality. In Experiment 1 ( N = 80), participants watched short videos depicting soccer players prior to a UEFA Champions League match and rated whether athletes were more likely to be playing at home or away. In Experiment 2 (two groups N = 102 and N = 101), perceivers rated these videos in terms of assertiveness, dominance, and aggression. In Experiment 3, we replicated the procedure of Experiments 1 and 2 with different stimulus material from amateur soccer ( N = 112). Participants could significantly differentiate between home playing and away playing athletes (Experiment 1: d = 0.44 and Experiment 3: d = 1.07). Experiments 2 and 3 showed that perceivers rated professional and amateur soccer players higher on assertiveness ( d = 0.34-0.63), dominance ( d = 0.20-0.55), and aggression ( d = 0.16-0.49) when playing at home compared to playing away. Findings are supportive of evolutionary accounts of nonverbal behavior, ecological approaches to person perception, and the thin slices of behavior hypothesis by demonstrating that humans change their nonverbal behavior depending on game location. We discuss the relevance of the present findings for the home advantage in sports.

An Analysis of Competencies for Managing Science and Technology Programs

DTIC Science & Technology

2008-03-19

competency modeling through a two-year task force commissioned by the Society for Industrial and Organizational Psychology (Shippmann and others, 2000:704...positions—specifically within Research and Development (R&D) programs. If so, the final investigative question tests whether those differences are...statistics are used to analyze the comparisons through hypothesis testing and t- tests relevant to the research investigative questions. These

Job Rotation in an Academic Library: Damned if You Do and Damned if You Don't!

ERIC Educational Resources Information Center

Malinski, Richard M.

2002-01-01

Considers job rotation, the systematic movement of employees from one job to another, as one of the tools for organizational development. Reviews relevant print and Internet literature, discusses the pros and cons of job rotation, and describes experiences at the Ryerson University library to illustrate process. (Author/LRW)

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Yong, E-mail: yongzhao@uic.edu; Guo, Chengshan; Hwang, David

2010-09-03

Research highlights: {yields} Establish a human immune-mediated type 1 diabetic model in NOD-scid IL2r{gamma}{sup null} mice. {yields} Using the irradiated diabetic NOD mouse spleen mononuclear cells as trigger. {yields} The islet {beta} cells were selectively destroyed by infiltrated human T cells. {yields} The model can facilitate translational research to find a cure for type 1 diabetes. -- Abstract: Type 1 diabetes (T1D) is caused by a T cell-mediated autoimmune response that leads to the loss of insulin-producing {beta} cells. The optimal preclinical testing of promising therapies would be aided by a humanized immune-mediated T1D model. We develop this model inmore » NOD-scid IL2r{gamma}{sup null} mice. The selective destruction of pancreatic islet {beta} cells was mediated by human T lymphocytes after an initial trigger was supplied by the injection of irradiated spleen mononuclear cells (SMC) from diabetic nonobese diabetic (NOD) mice. This resulted in severe insulitis, a marked loss of total {beta}-cell mass, and other related phenotypes of T1D. The migration of human T cells to pancreatic islets was controlled by the {beta} cell-produced highly conserved chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C-X-C chemokine receptor (CXCR) 4, as demonstrated by in vivo blocking experiments using antibody to CXCR4. The specificity of humanized T cell-mediated immune responses against islet {beta} cells was generated by the local inflammatory microenvironment in pancreatic islets including human CD4{sup +} T cell infiltration and clonal expansion, and the mouse islet {beta}-cell-derived CD1d-mediated human iNKT activation. The selective destruction of mouse islet {beta} cells by a human T cell-mediated immune response in this humanized T1D model can mimic those observed in T1D patients. This model can provide a valuable tool for translational research into T1D.« less

Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers.

PubMed

de Moraes, Natália Valadares; Lauretti, Gabriela Rocha; Lanchote, Vera Lucia

2014-09-01

The aim of this study was to evaluate the influence of poorly controlled type 1 (T1DM) and type 2 diabetes mellitus (T2DM) on the pharmacokinetics and metabolism of tramadol enantiomers in patients with neuropathic pain. Nondiabetic patients (control group, n = 12), patients with T1DM (n = 9) or T2DM (n = 9), all with neuropathic pain and phenotyped as cytochrome P450 2D6 extensive metabolizers, received a single oral dose of 100 mg racemic tramadol. Serial blood samples were collected over a 24-h period. Patients with T1DM showed reduced Cmax of both tramadol enantiomers. The plasma concentrations of the active (+)-M1 were significantly reduced in T1DM (area under the curve plasma concentration versus time (AUC∞ ): 313.1 ng·h/ml) when compared with nondiabetic patients (AUC∞ : 1246.6 ng·h/ml). The fraction unbound of (+)-M1 was increased in patients with T1DM. Patients with T1DM and T2DM showed reduced AUC and increased fraction unbound of (-)-M1. The reduced total plasma concentrations of the active (+)-M1 in patients with T1DM may not be of clinical relevance because they are counterbalanced by the increased fraction unbound. © 2014 Royal Pharmaceutical Society.

The awareness of novelty for strangely familiar words: a laboratory analogue of the déjà vu experience.

PubMed

Urquhart, Josephine A; O'Connor, Akira R

2014-01-01

Déjà vu is a nebulous memory experience defined by a clash between evaluations of familiarity and novelty for the same stimulus. We sought to generate it in the laboratory by pairing a DRM recognition task, which generates erroneous familiarity for critical words, with a monitoring task by which participants realise that some of these erroneously familiar words are in fact novel. We tested 30 participants in an experiment in which we varied both participant awareness of stimulus novelty and erroneous familiarity strength. We found that déjà vu reports were most frequent for high novelty critical words (∼25%), with low novelty critical words yielding only baseline levels of déjà vu report frequency (∼10%). There was no significant variation in déjà vu report frequency according to familiarity strength. Discursive accounts of the experimentally-generated déjà vu experience suggest that aspects of the naturalistic déjà vu experience were captured by this analogue, but that the analogue was also limited in its focus and prone to influence by demand characteristics. We discuss theoretical and methodological considerations relevant to further development of this procedure and propose that verifiable novelty is an important component of both naturalistic and experimental analogues of déjà vu.

The awareness of novelty for strangely familiar words: a laboratory analogue of the déjà vu experience

PubMed Central

Urquhart, Josephine A.

2014-01-01

Déjà vu is a nebulous memory experience defined by a clash between evaluations of familiarity and novelty for the same stimulus. We sought to generate it in the laboratory by pairing a DRM recognition task, which generates erroneous familiarity for critical words, with a monitoring task by which participants realise that some of these erroneously familiar words are in fact novel. We tested 30 participants in an experiment in which we varied both participant awareness of stimulus novelty and erroneous familiarity strength. We found that déjà vu reports were most frequent for high novelty critical words (∼25%), with low novelty critical words yielding only baseline levels of déjà vu report frequency (∼10%). There was no significant variation in déjà vu report frequency according to familiarity strength. Discursive accounts of the experimentally-generated déjà vu experience suggest that aspects of the naturalistic déjà vu experience were captured by this analogue, but that the analogue was also limited in its focus and prone to influence by demand characteristics. We discuss theoretical and methodological considerations relevant to further development of this procedure and propose that verifiable novelty is an important component of both naturalistic and experimental analogues of déjà vu. PMID:25401055

T2L2 on JASON-2: First Evaluation of the Flying Model

DTIC Science & Technology

2007-01-01

Para, J.-M. Torre R&D Metrology CNRS/GEMINI Observatoire de la Côte d’Azur Caussol, France E-mail: philippe.guillemot@cnes.fr Abstract...Laser Link” experiment T2L2 [1], under development at OCA (Observatoire de la Côte d’Azur) and CNES (Centre National d’Etudes Spatiales), France, will be...Experimental Astronomy, 7, 191-207. [2] P. Fridelance and C. Veillet, 1995, “Operation and data analysis in the LASSO experiment,” Metrologia

The UOSAT magnetometer experiment

NASA Technical Reports Server (NTRS)

Acuna, M. H.

1982-01-01

The magnetometer aboard the University of Surrey satellite (UOSAT) and its associated electronics are described. The basic fluxgate magnetometer employed has a dynamic range of plus or minus 8000 nT with outputs digitized by a 12-bit successive approximation A-D converter having a resolution of plus or minus 2 nT. Noise in the 3-13 Hz bandwidth is less than 1 nT. A bias field generator extends the dynamic range to plus or minus 64,000 nT with quantization steps of 8000 nT. The magnetometer experiment is expected to provide information on the secular variation of the geomagnetic field, and the decay rate of the dipole term. Special emphasis will be placed on the acquisition of real time and memory data over the poles which can be correlated with that from Magsat.

Visual Representations of DNA Replication: Middle Grades Students' Perceptions and Interpretations

NASA Astrophysics Data System (ADS)

Patrick, Michelle D.; Carter, Glenda; Wiebe, Eric N.

2005-09-01

Visual representations play a critical role in the communication of science concepts for scientists and students alike. However, recent research suggests that novice students experience difficulty extracting relevant information from representations. This study examined students' interpretations of visual representations of DNA replication. Each of the four steps of DNA replication included in the instructional presentation was represented as a text slide, a simple 2D graphic, and a rich 3D graphic. Participants were middle grade girls ( n = 21) attending a summer math and science program. Students' eye movements were measured as they viewed the representations. Participants were interviewed following instruction to assess their perceived salient features. Eye tracking fixation counts indicated that the same features (look zones) in the corresponding 2D and 3D graphics had different salience. The interviews revealed that students used different characteristics such as color, shape, and complexity to make sense of the graphics. The results of this study have implications for the design of instructional representations. Since many students have difficulty distinguishing between relevant and irrelevant information, cueing and directing student attention through the instructional representation could allow cognitive resources to be directed to the most relevant material.

Impulsive correction to the elastic moduli obtained using the stress-fluctuation formalism in systems with truncated pair potential

NASA Astrophysics Data System (ADS)

Xu, H.; Wittmer, J. P.; Polińska, P.; Baschnagel, J.

2012-10-01

The truncation of a pair potential at a distance rc is well known to imply, in general, an impulsive correction to the pressure and other moments of the first derivatives of the potential. That, depending on rc, the truncation may also be of relevance to higher derivatives is shown theoretically for the Born contributions to the elastic moduli obtained using the stress-fluctuation formalism in d dimensions. Focusing on isotropic liquids for which the shear modulus G must vanish by construction, the predicted corrections are tested numerically for binary mixtures and polydisperse Lennard-Jones beads in, respectively, d=3 and 2 dimensions. Both models being glass formers, we comment briefly on the temperature (T) dependence of the (corrected) shear modulus G(T) around the glass transition temperature Tg.

T cell epitope-specific defects in the immune response to cat allergen in patients with atopic dermatitis.

PubMed

Carneiro, Raquel; Reefer, Amanda; Wilson, Barbara; Hammer, Juergen; Platts-Mills, Thomas; Custis, Natalie; Woodfolk, Judith

2004-04-01

Atopic dermatitis (AD) is often associated with high titer IgE antibodies (ab) to allergens, and IL-10-mediated regulation of IFN-gamma has been proposed to contribute to this IgE ab production. However, the relevance of IL-10 and IFN-gamma to IgE associated with AD has not been examined in the context of an allergen-specific system. Analysis of PBMC responses in vitro showed deficient T cell proliferation to overlapping IL-10- (peptide (P) 2:1) and IFN-gamma- (P2:2) inducing chain 2 major epitopes of cat allergen (Fel d 1) in cultures from sensitized AD patients (mean IgE to cat=20.9 IU/ml). Diminished IFN-gamma induction by Fel d 1 and P2:2, along with elevated peptide-induced IL-10 (except for P2:1) was observed in PBMC cultures from AD subjects compared with non-AD (sensitized and non-sensitized) subjects. Neither T cell proliferation nor IFN-gamma production to chain 2 epitopes could be restored by anti-IL-10 mAb in cultures from sensitized AD subjects. Moreover, allergen avoidance was associated with a paradoxical decrease in both IL-10 and IFN-gamma in peptide-stimulated PBMC from these subjects. Control of IFN-gamma production to chain 2 epitopes by IL-10 may be relevant to sensitization status. Development of high titer IgE ab in AD could reflect a failure of this mechanism.

Nuclear quantum effects of light and heavy water studied by all-electron first principles path integral simulations

NASA Astrophysics Data System (ADS)

Machida, Masahiko; Kato, Koichiro; Shiga, Motoyuki

2018-03-01

The isotopologs of liquid water, H2O, D2O, and T2O, are studied systematically by first principles PIMD simulations, in which the whole entity of the electrons and nuclei are treated quantum mechanically. The simulation results are in reasonable agreement with available experimental data on isotope effects, in particular, on the peak shift in the radial distributions of H2O and D2O and the shift in the evaporation energies. It is found that, due to differences in nuclear quantum effects, the H atoms in the OH bonds more easily access the dissociative region up to the hydrogen bond center than the D (T) atoms in the OD (OT) bonds. The accuracy and limitation in the use of the current density-functional-theory-based first principles PIMD simulations are also discussed. It is argued that the inclusion of the dispersion correction or relevant improvements in the density functionals are required for the quantitative estimation of isotope effects.

On the vanishing of the t-term in the short-time expansion of the diffusion coefficient for oscillating gradients in diffusion NMR

NASA Astrophysics Data System (ADS)

Laun, Frederik B.; Demberg, Kerstin; Nagel, Armin M.; Uder, Micheal; Kuder, Tristan A.

2017-11-01

Nuclear magnetic resonance (NMR) diffusion measurements can be used to probe porous structures or biological tissues by means of the random motion of water molecules. The short-time expansion of the diffusion coefficient in powers of sqrt(t), where t is the diffusion time related to the duration of the diffusion-weighting magnetic field gradient profile, is universally connected to structural parameters of the boundaries restricting the diffusive motion. The sqrt(t)-term is proportional to the surface to volume ratio. The t-term is related to permeability and curvature. The short time expansion can be measured with two approaches in NMR-based diffusion experiments: First, by the use of diffusion encodings of short total duration and, second, by application of oscillating gradients of long total duration. For oscillating gradients, the inverse of the oscillation frequency becomes the relevant time scale. The purpose of this manuscript is to show that the oscillating gradient approach is blind to the t-term. On the one hand, this prevents fitting of permeability and curvature measures from this term. On the other hand, the t-term does not bias the determination of the sqrt(t)-term in experiments.

Transport of high intensity laser-generated hot electrons in cone coupled wire targets

NASA Astrophysics Data System (ADS)

Beg, Farhat

2008-04-01

In this talk, we present results from a series of experiments where cone-wire targets were employed both to assess hot electron coupling efficiency, and to reveal the source temperature of the hot electrons. Experiments were performed on the petawatt laser at the Rutherford Appleton Laboratory. A 500J, 1ps laser (I ˜ 4 x 10^20 W/cm-2) was focused by an f/3 off-axis parabolic mirror into hollow aluminum cones joined at their tip to Cu wires of diameters from 10 to 40 μm. The three main diagnostics fielded were a copper Kalpha Bragg crystal imager, a single hit CCD camera spectrometer and a Highly Oriented Pyrolytic Graphite (HOPG) spectrometer. The resulting data were cross-calibrated to obtain the absolute Kalpha yield. Comparison of the axially diminishing absolute Cu Kα intensity with modeling shows that the penetration of the hot electrons is consistent with one dimensional ohmic potential limited transport (1/e length ˜ 100 μm). The laser coupling efficiency to electron energy within the wire is shown to be proportional to the cross sectional area of the wire, reaching 15% for 40 μm wires. We find that the hot electron temperature within the wire was <=750 keV, significantly lower than that predicted by the ponderomotive scaling. A comparison of the experimental results with 2D hybrid PIC simulations using e-PLAS code will be presented and relevance to Fast Ignition will be discussed at the meeting. *In collaboration with J.A. King, M.H. Key, K.U. Akli, R.R. Freeman, J. Green, S. P. Hatchett, D. Hey, P. Jaanimagi, J. Koch, K. L. Lancaster, T. Ma, A.J. MacKinnon, A. MacPhee, R. Mason, P.A. Norreys, P.K Patel, T. Phillips, R. Stephens, W. Theobald, R.P.J. Town, M. Wei, L. Van Woerkom, B. Zhang.

Two-dimensional NMR spectroscopy of 13C methanol at less than 5 μT

NASA Astrophysics Data System (ADS)

Shim, Jeong Hyun; Lee, Seong-Joo; Hwang, Seong-min; Yu, Kwon-Kyu; Kim, Kiwoong

2014-09-01

Two-dimensional (2D) spectroscopy is one of the most significant applications of nuclear magnetic resonance (NMR). Here, we demonstrate that the 2D NMR can be performed even at a low magnetic field of less than 5 μT, which is ten times less than the Earth’s magnetic field. The pulses used in the experiment were composed of circularly polarized fields for coherent as well as wideband excitations. Since the excitation band covers the entire spectral range, the simplest two-pulse sequence delivered the full 2D spectrum. At 5 μT, methanol with 13C enriched up to 99% belongs to a strongly coupled regime, and thus its 2D spectrum exhibits complicated spectral correlations, which can be exploited as a fingerprint in chemical analysis. In addition, we show that, with compressive sensing, the acquisition of the 2D spectrum can be accelerated to take only 45% of the overall duration.

Helium experiments on Alcator C-Mod in support of ITER early operations

NASA Astrophysics Data System (ADS)

Kessel, C. E.; Wolfe, S. M.; Reinke, M. L.; Hughes, J. W.; Lin, Y.; Wukitch, S. J.; Baek, S. G.; Bonoli, P. T.; Chilenski, M.; Diallo, A.; the Alcator C-Mod Team

2018-05-01

Helium majority experiments on Alcator C-Mod were performed to compare with deuterium discharges, and inform ITER early operations. ELMy H-modes were produced with a special plasma shape at B T  =  5.3 T, I P  =  0.9 MA, at q 95 ~ 3.8. The He fraction ranged over, n He,L/n L  =  0.2-0.4, with n D,L/n L  =  0.15-0.26, compared to D plasmas with n D,L/n L  =  0.85-0.97. The power to enter the H-mode in He was found to be greater than ~2 times that for D discharges, in the low density region  <1.4  ×  1020/m3. However, it appears to follow the D threshold for higher densities. The stored energies in the He discharges were about 80% of those in D, and about 40% higher net power was required to sustain them compared to D. Global particle confinement times for tungsten of τ W* /τ E ~ 4 were obtained with ELMy H-modes in He, however accumulation occurred when the ELMs were irregular and infrequent. The electron temperatures and densities in the pedestal were similar between D and He discharges, and the ΔT e/T e and Δn e/n e values were similar or larger in He than D. The higher net power required to access the H-mode, and sustain it in flattop, for He discharges in C-Mod, imply some limitations for He operation in ITER.

Effect of Salmonella infection on cecal tonsil regulatory T cell properties in chickens

USDA-ARS?s Scientific Manuscript database

Two experiments were conducted to study Regulatory T cell (Treg) properties post-Salmonella infection in broiler birds. Four-day-old broiler chicks were orally infected with 5x106 CFU/ml Salmonella enteritidis or sterile PBS (control). Samples were collected at 4, 7, 10, and 14 d post-infection. ...

Unveiling Singlet Fission Mediating States in TIPS-pentacene and its Aza Derivatives.

PubMed

Herz, Julia; Buckup, Tiago; Paulus, Fabian; Engelhart, Jens U; Bunz, Uwe H F; Motzkus, Marcus

2015-06-25

Femtosecond pump-depletion-probe experiments were carried out in order to shed light on the ultrafast excited-state dynamics of triisopropylsilylethynyl (TIPS)-pentacene and two nitrogen-containing derivatives, namely, diaza-TIPS-pentacene and tetraaza-TIPS-pentacene. Measurements performed in the visible and near-infrared spectral range in combination with rate model simulations reveal that singlet fission proceeds via the extremely short-lived intermediate (1)TT state, which absorbs in the near-infrared spectral region only. The T1 → T3 transition probed in the visible region shows a rise time that comprises two components according to a consecutive reaction (S1 → (1)TT → T1). The incorporation of nitrogen atoms into the acene structure leads to shorter dynamics, but the overall triplet formation follows the same kinetic model. This is of particular importance, since experiments on tetraaza-TIPS-pentacene allow for investigation of the triplet state in the visible range without an overlapping singlet contribution. In addition, the pump-depletion-probe experiments show that the triplet absorption in the visible (T1 → T3) and near-infrared (T1 → T2) regions occurs from the same initial state, which was questioned in previous studies. Furthermore, an additional ultrafast transfer between the excited triplet states (T3 → T2) is identified, which is also in agreement with the rate model simulation. By applying depletion pulses, which are resonant with higher vibrational levels, we gain insight into internal vibrational energy redistribution processes within the triplet manifold. This additional information is of great relevance regarding the study of loss channels within these materials.

The B-Raf Status of Tumor Cells May Be a Significant Determinant of Both Antitumor and Anti-Angiogenic Effects of Pazopanib in Xenograft Tumor Models

DTIC Science & Technology

2011-10-05

B-Raf status was identified as a significant determinant of both tumor growth and angiogenesis. Citation: Gril B, Palmieri D , Qian Y, Anwar T, Ileva L...231-B R EJ MCF7-HER2 D MCF7 100mg/kg * 30m g/kg 100mg/kg * * • WM3899 ElWM3918 DSKMEL28 DSKMEL2 30mg/kg * * * * 30mg/kg 100mg/kg c...without any pazopanib treatment (average of the three experiments). D - Cell viability by MTT assay at T96 with the indicated Pazopanib treatments. (PDF

Arabitol Metabolism of Corynebacterium glutamicum and Its Regulation by AtlR

PubMed Central

Laslo, Tanja; von Zaluskowski, Philipp; Gabris, Christina; Lodd, Elisabeth; Rückert, Christian; Dangel, Petra; Kalinowski, Jörn; Auchter, Marc; Seibold, Gerd

2012-01-01

Expression profiling of Corynebacterium glutamicum in comparison to a derivative deficient in the transcriptional regulator AtlR (previously known as SucR or MtlR) revealed eight genes showing more than 4-fold higher mRNA levels in the mutant. Four of these genes are located in the direct vicinity of the atlR gene, i.e., xylB, rbtT, mtlD, and sixA, annotated as encoding xylulokinase, the ribitol transporter, mannitol 2-dehydrogenase, and phosphohistidine phosphatase, respectively. Transcriptional analysis indicated that atlR and the four genes are organized as atlR-xylB and rbtT-mtlD-sixA operons. Growth experiments with C. glutamicum and C. glutamicum ΔatlR, ΔxylB, ΔrbtT, ΔmtlD, and ΔsixA derivatives with sugar alcohols revealed that (i) wild-type C. glutamicum grows on d-arabitol but not on other sugar alcohols, (ii) growth in the presence of d-arabitol allows subsequent growth on d-mannitol, (iii) d-arabitol is cometabolized with glucose and preferentially utilized over d-mannitol, (iv) RbtT and XylB are involved in d-arabitol but not in d-mannitol metabolism, (v) MtlD is required for d-arabitol and d-mannitol metabolism, and (vi) SixA is not required for growth on any of the substrates tested. Furthermore, we show that MtlD confers d-arabitol and d-mannitol dehydrogenase activities, that the levels of these and also xylulokinase activities are generally high in the C. glutamicum ΔatlR mutant, whereas in the parental strain, they were high when cells were grown in the presence of d-arabitol and very low when cells were grown in its absence. Our results show that the XylB, RbtT, and MtlD proteins allow the growth of C. glutamicum on d-arabitol and that d-arabitol metabolism is subject to arabitol-dependent derepression by AtlR. PMID:22178972

Antibody Response to Serpin B13 Induces Adaptive Changes in Mouse Pancreatic Islets and Slows Down the Decline in the Residual Beta Cell Function in Children with Recent Onset of Type 1 Diabetes Mellitus.

PubMed

Kryvalap, Yury; Lo, Chi-Wen; Manuylova, Ekaterina; Baldzizhar, Raman; Jospe, Nicholas; Czyzyk, Jan

2016-01-01

Type 1 diabetes mellitus (T1D) is characterized by a heightened antibody (Ab) response to pancreatic islet self-antigens, which is a biomarker of progressive islet pathology. We recently identified a novel antibody to clade B serpin that reduces islet-associated T cell accumulation and is linked to the delayed onset of T1D. As natural immunity to clade B arises early in life, we hypothesized that it may influence islet development during that time. To test this possibility healthy young Balb/c male mice were injected with serpin B13 mAb or IgG control and examined for the number and cellularity of pancreatic islets by immunofluorescence and FACS. Beta cell proliferation was assessed by measuring nucleotide analog 5-ethynyl-2'-deoxyuridine (5-EdU) incorporation into the DNA and islet Reg gene expression was measured by real time PCR. Human studies involved measuring anti-serpin B13 autoantibodies by Luminex. We found that injecting anti-serpin B13 monoclonal Ab enhanced beta cell proliferation and Reg gene expression, induced the generation of ∼80 pancreatic islets per animal, and ultimately led to increase in the beta cell mass. These findings are relevant to human T1D because our analysis of subjects just diagnosed with T1D revealed an association between baseline anti-serpin activity and slower residual beta cell function decline in the first year after the onset of diabetes. Our findings reveal a new role for the anti-serpin immunological response in promoting adaptive changes in the endocrine pancreas and suggests that enhancement of this response could potentially help impede the progression of T1D in humans. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

High-Risk Series: An Update

DTIC Science & Technology

2011-02-01

achieve savings as the b ards than e t the ases gain experience with consolidation and the common standards and new operational efficiencies are... Operations Center to help coordinate the movement of materiel and forces. However, GAO’s review of supply support for t in Afghanistan found that DOD...Needed to Improve Implementation of t Army Logistics Modernization Program. GAO-10-461. Washington, D April 30, 2010. Operation Iraqi Freedom: Actions

Impact of type 1 diabetes mellitus on the family is reduced with the medical home, care coordination, and family-centered care.

PubMed

Katz, Michelle L; Laffel, Lori M; Perrin, James M; Kuhlthau, Karen

2012-05-01

To examine whether the medical home, care coordination, or family-centered care was associated with less impact of type 1 diabetes mellitus (T1D) on families' work, finances, time, and school attendance. With the 2005 to 2006 National Survey of Children with Special Health Care Needs, we compared impact in children with T1D (n = 583) with that in children with other special health care needs (n = 39 944) and children without special health care needs (n = 4945). We modeled the associations of the medical home, care coordination, and family-centered care with family impact in T1D. Seventy-five percent of families of children with T1D reported a major impact compared with 45% of families of children with special health care needs (P < .0001) and 17% of families of children without special health care needs (P < .0001). In families of children with T1D, 35% reported restricting work, 38% reported financial impact, 41% reported medical expenses >$1000/year, 24% reported spending ≥11 hours/week caring or coordination care, and 20% reported ≥11 school absences/year. The medical home, care coordination, and family-centered care were associated with less work and financial impact. In childhood T1D, most families experience major impact. Better systems of health care delivery may help families reduce some of this impact. Copyright © 2012 Mosby, Inc. All rights reserved.

The Pegasus-Upgrade Experiment

NASA Astrophysics Data System (ADS)

Fonck, R. J.; Bongard, M. W.; Barr, J. L.; Frerichs, H. G.; Lewicki, B. T.; Reusch, J. A.; Schmitz, O.; Winz, G. R.

2015-11-01

Tokamak operation at near-unity aspect ratio provides access to advanced tokamak physics at modest parameters. High plasma current is accessible at very low toroidal field. This offers H-mode performance at Te levels that allow use of electrostatic and magnetic probe arrays through the edge pedestal region into the plasma core. An upgrade to the Pegasus ST is planned to exploit these features and pursue unique studies in three areas: local measurements of pedestal and ELM dynamics at Alfvenic timescales; direct measurement of the local plasma response to application of 3D magnetic perturbations with high spectral flexibility; and extension of Local Helicity Injection for nonsolenoidal startup to NSTX-U-relevant confinement and stability regimes. Significant but relatively low-cost upgrades to the facility are proposed: a new centerstack with larger solenoid and 2x the number of toroidal field conductors; a new TF power supply and conversion of the 200 MVA OH power supply to a cascaded multilevel inverter configuration; and installation of an extensive 3D-magnetic perturbation coil system for ELM mitigation and suppression studies. The upgraded facility will provide 0.3 MA plasmas with pulse lengths of 50-100 msec flattop, aspect ratio <1.25, and toroidal field up to 0.4 T. These research activities will be integrated into related efforts on DIII-D and NSTX-U. Work supported by US DOE grant DE-FG02-96ER54375.

Evaluation of a Salmonella Enteritidis vaccine and related ELISA for respective induction and assessment of acquired immunity to the vaccine and/or Echinacea purpurea in Awassi Ewes.

PubMed

Barbour, Elie K; Assi, Chibli A Abou; Shaib, Houssam; Hamadeh, Shadi; Murtada, Muhammad; Mahmoud, Ghassan; Yaghmoor, Soonham; Iyer, Archana; Harakeh, Steve; Kumosani, Taha

2015-05-05

The aim of this study was to evaluate an experimental Salmonella Enteritidis (SE) bacterin and an indirect ELISA system to assess quantitatively the acquired immunity in Awassi ewes to the vaccine and/or Echinacea purpurea (EP) dried roots. Four treatments of the ewes were included in the experimental design, with 6 ewes/treatment. The first treatment (T1) had the controls that were non-vaccinated and non-treated with EP. The T2 ewes were only treated with EP. The T3 and T4 ewes were vaccinated at D1 (initiation of trial) and D10, while the T4 ewes were additionally administered the EP dried roots. Blood was collected from the jugular vein of all ewes at D1, D10, D21 and D45. The construction of the vaccine and the ELISA are detailed within the manuscript. The ELISA was able to detect quantitatively the significant acquired primary and secondary immunity to the vaccine in T3 and T4 ewes, compared to their low level of background immunities at initiation of the experiment (p<0.05). In addition, the ELISA detected the absence of seroconversion at all blood sampling times (p>0.05) in T1 control ewes, and in the T2 ewes that were given only the (EP) (p>0.05). Moreover, the ELISA was able to uncover the significant seroconversion of secondary immune response in T4 ewes at D21 compared to that at D10 (p<0.05), and the absence of significant seroconversion of secondary response in T3 ewes. This is the first work in literature that reports the need to supplement the vaccination by the experimental SE bacterin with daily oral intake of 250mg of EP-dried roots, effective the first vaccination day and up to 21 days, for obtaining a statistically significant seroconversion. Copyright © 2015 Elsevier Ltd. All rights reserved.

Interferon in resistance to bacterial and protozoan infections

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Gould, Cheryl L.; Kierszenbaum, Felipe; Degee, Antonie L. W.; Mansfield, John M.

1986-01-01

The effects of genetic differences in mouse strains on the modulation of protozoan infections by interferon (IFN) were investigated. In one set of experiments, three different strains of mice were injected with T. cruzi, and their sera were assayed at five time intervals for IFN titer. A greater quantity of IFN was produced by mouse strains that were susceptible to T. cruzi infection than by the more resistant strain. In another set of experiments, spleen cell cultures from inbred strains of mice were challenged with an antigen made from T.b. rhodesiense. The cells from mice resistant to infection, produced greater amounts of IFN-gamma than did cells from the susceptible mice. In a third set of experiments, it was found that mice injected with T.b. rhodesiense before being infected with a diabetogenic virus (EMC-D) were resistant to the effects of the virus and did not produce virus-specific antibody.

Element-specific observation of the ferromagnetic ordering process in UCoAl via soft x-ray magnetic circular dichroism

NASA Astrophysics Data System (ADS)

Takeda, Yukiharu; Saitoh, Yuji; Okane, Tetsuo; Yamagami, Hiroshi; Matsuda, Tatsuma D.; Yamamoto, Etsuji; Haga, Yoshinori; Ōnuki, Yoshichika

2018-05-01

We have performed soft x-ray magnetic circular dichroism (XMCD) experiments on the itinerant-electron metamagnet UCoAl at the U 4 d -5 f (N4 ,5) and Co 2 p -3 d (L2 ,3) absorption edges in order to investigate the magnetic properties of the U 5 f and Co 3 d electrons separately. From the line shape of the XMCD spectrum, it is deduced that the orbital magnetic moment of the Co 3 d electrons is unusually large. Through the systematic temperature (T )- and magnetic field (H )-dependent XMCD measurements, we have obtained two types of the magnetization curve as a function of H and T (M-H curve and M-T curve, respectively). The metamagnetic transition from a paramagnetic state to a field-induced ferromagnetic state was clearly observed under 15 K at HM. The value of the HM and its T dependence agree well between the U and Co sites, and the bulk magnetization. Whereas, we have discovered the remarkable differences in the M-H and M-T curves between the U and Co sites. The present findings clearly show that the role of the Co 3 d electrons should be considered more carefully in order to understand the origin of the magnetic ordering in UCoAl.

[Depersonalization and déjà vu experiences: prevalences in nonclinical samples].

PubMed

Probst, P; Jansen, J

1991-01-01

According to the relevant psychological and psychiatric literature, depersonalization and déjà vu experiences are usually viewed as symptoms of severe psychiatric or neurological disorders, especially in schizophrenia, depression and epilepsy. Studies of these phenomena in non-clinical populations are rate. In this article we present the results of several epidemiological investigations. On the basis of survey and interview research, quantitative and qualitative aspects of both phenomena were assessed, as well as the relations with personality variables like emotionality. The results indicate prevalence rates up to 80 percent in non-clinical populations. Based on epidemiological considerations, the question of differentiation between clinical and non-clinical forms of depersonalization and déjà vu is discussed.

Characterization of a cultured human T-cell line with genetically altered ribonucleotide reductase activity. Model for immunodeficiency.

PubMed

Waddell, D; Ullman, B

1983-04-10

From human CCRF-CEM T-cells growing in continuous culture, we have selected, isolated, and characterized a clonal cell line, APHID-D2, with altered ribonucleotide reductase activity. In comparative growth rate experiments, the APHID-D2 cell line is less sensitive than the parental cell line to growth inhibition by deoxyadenosine in the presence of 10 microM erythro-9-(2-hydroxy-3-nonyl)adenine, an inhibitor of adenosine deaminase. The APHID-D2 cell line has elevated levels of all four dNTPs. The resistance of the APHID-D2 cell line to growth inhibition by deoxyadenosine and the abnormal dNTP levels can be explained by the fact that the APHID-D2 ribonucleotide reductase, unlike the parental ribonucleotide reductase, is not normally sensitive to inhibition by dATP. These results suggest that the allosteric site of ribonucleotide reductase which binds both dATP and ATP is altered in the APHID-D2 line. The isolation of a mutant clone of human T-cells which contains a ribonucleotide reductase that has lost its normal sensitivity to dATP and which is resistant to deoxyadenosine-mediated growth inhibition suggests that a primary pathogenic target of accumulated dATP in lymphocytes from patients with adenosine deaminase deficiency may be the cellular ribonucleotide reductase.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casey, D. T.; Sayre, D. B.; Brune, C. R.

Stars are giant thermonuclear plasma furnaces that slowly fuse the lighter elements in the universe into heavier elements, releasing energy, and generating the pressure required to prevent collapse. To understand stars, we must rely on nuclear reaction rate data obtained, up to now, under conditions very different from those of stellar cores. Here we show thermonuclear measurements of the 2H(d, n) 3He and 3H(t,2n) 4He S-factors at a range of densities (1.2–16 g cm –3) and temperatures (2.1–5.4 keV) that allow us to test the conditions of the hydrogen-burning phase of main-sequence stars. The relevant conditions are created using inertial-confinementmore » fusion implosions at the National Ignition Facility. Here, our data agree within uncertainty with previous accelerator-based measurements and establish this approach for future experiments to measure other reactions and to test plasma-nuclear effects present in stellar interiors, such as plasma electron screening, directly in the environments where they occur.« less

Thyroid Dysfunction and Anemia: A Prospective Cohort Study and a Systematic Review.

PubMed

Floriani, Carmen; Feller, Martin; Aubert, Carole E; M'Rabet-Bensalah, Khadija; Collet, Tinh-Hai; den Elzen, Wendy P J; Bauer, Douglas C; Angelillo-Scherrer, Anne; Aujesky, Drahomir; Rodondi, Nicolas

2018-05-01

Even though the association between thyroid dysfunction and anemia is commonly described, it is not known whether it is clinically relevant. This study set out to quantify the association of thyroid dysfunction on hemoglobin (Hb) concentration and risk of anemia. A systematic review (MEDLINE and EMBASE, from inception until May 15, 2017) was conducted to interpret the findings in context. Participants from the EPIC-Norfolk cohort with available baseline thyrotropin (TSH), free thyroxine (fT4), and Hb were included. Euthyroidism was defined as TSH 0.45-4.49 mIU/L (reference category), hypothyroidism as TSH ≥4.50 mIU/L (subclinical [SHypo] with normal fT4 or overt [OHypo] with low fT4), and hyperthyroidism as TSH ≤0.44 mIU/L (subclinical [SHyper] with normal fT4 or overt [OHyper] with elevated fT4). Anemia was defined as Hb <12 g/dL in women and Hb <13 g/dL in men. In the cross-sectional analyses, multiple linear regression was used to compare Hb across TSH categories. In the prospective analysis, participants with OHypo/OHyper at baseline were excluded, as it was assumed that they were treated for overt thyroid disease. A covariance model was used to determine change in Hb concentration from baseline to last follow-up, and multivariable Cox regression was used to analyze anemia risk. In the cross-sectional population (n = 12,337), the adjusted Hb was 0.22 g/dL lower [confidence interval (CI) 0.07-0.38] in OHypo compared to euthyroids, and 0.08 g/dL lower [CI -0.23 to 0.38] in OHyper. In the prospective analysis, 460/7031 participants developed anemia over a median follow-up of 4.7 years. The adjusted mean Hb change over time was -0.04 g/dL in SHypo [CI -0.14 to 0.06] and 0.05 g/dL in SHyper [CI -0.10 to 0.20]. The adjusted hazard ratio for anemia was 0.99 [CI 0.67-1.48] in SHypo, and 0.52 [CI 0.23-1.16] in SHyper. The systematic review returned no other prospective studies on this association, but cross-sectional and case-control studies showed comparable results. In this first prospective population-based cohort, subclinical thyroid dysfunction was not associated with a change in Hb concentration during follow-up and was not an independent risk factor for developing anemia; variations in Hb concentration in patients with overt thyroid dysfunction were not clinically relevant.

[Multicenter international registry to evaluate the clinical practice delivered to patients with type 2 diabetes mellitus: a sub-analysis of the experience in Mexico].

PubMed

Fanghänel Salmón, Guillermo; Sánchez-Reyes, Leticia; Chiquete Anaya, Erwin; de la Luz Castro, Julieta; Escalante Herrera, Antonio

2011-01-01

There is a lack of information on the characteristics of the medical attention delivered to Mexican patients with type 2 diabetes (T2D). Our aim was to describe the current state on the medical management of T2D in Mexico. Among 17,232 patients included in the International Diabetes Management Practices Study (IDMPS), 2,620 (15%) corresponded to Mexico. Information regarding clinical, demographics and management characteristics, as well as the impact of T2D in the patient is clinical and social condition was registered. The metabolic control and achievement of therapeutic goals were also analyzed. Diagnosis of T2D was performed by the general practitioner in 76% of cases. Only about a quarter of the cohort had a blood pressure goal of < 130/80 mmHg, although 97% had anti-hypertensive treatment. Management of T2D was with diet and exercise exclusively in 5%, with oral glucose-lowering drugs (OGLD) in 66% (alone or combined), with OGLD and insulin in 18%, and with insulin alone in 11%. Only 31% of patients reached the goal of HbA1c < 7. Self-monitoring was practiced in 50% of patients and 26% received education on diabetes. The managing physician is personal impression about the quality of the metabolic control was not in accordance with HbA1c. Eight percent of patients had work absences in the last 3 months due to complications of T2D (mean of 15 days lost). In Mexico, quality of metabolic control of T2D patients could have important deficiencies. The personal impression of the physician on the patient is metabolic control is not consistent with objective data.

The uses and abuses of Vitamin D compounds in chronic kidney disease-mineral bone disease (CKD-MBD).

PubMed

Goldsmith, D J A; Massy, Z A; Brandenburg, V

2014-11-01

Vitamin D is of paramount importance to skeletal development, integrity and health. Vitamin D homeostatis is typically deranged in a number of chronic conditions, of which chronic kidney disease is one of the most important. The use of vitamin D based therapy to target secondary hyperparathyroidism is now several decades old, and there is a large body of clinical practice, experience, guidelines and research to underpin this. However, there are many unknowns, of significant clinical relevance. Amongst which is what "species" of vitamin D we should be using, in what patient, and, under what conditions. Sadly, there has been a real dearth of randomised controlled trials, and trials with outputs of clinical relevance, which means our clinical practice has not developed and refined adequately ove the last 4 decades. This article will discuss the vexed but critical questions of which vitamin D therapies might suit which kidney patients, and will high-light the many important clinical questions which urgently require answering. Copyright © 2014. Published by Elsevier Inc.

Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

PubMed Central

Schwarz, Sandra; West, T. Eoin; Boyer, Frédéric; Chiang, Wen-Chi; Carl, Mike A.; Hood, Rachel D.; Rohmer, Laurence; Tolker-Nielsen, Tim; Skerrett, Shawn J.; Mougous, Joseph D.

2010-01-01

Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia thailandensis (B. thai) in eukaryotic and bacterial cell interactions. Consistent with phylogenetic analyses comparing the distribution of the B. thai T6SSs with well-characterized bacterial and eukaryotic cell-targeting T6SSs, we found that T6SS-5 plays a critical role in the virulence of the organism in a murine melioidosis model, while a strain lacking the other four T6SSs remained as virulent as the wild-type. The function of T6SS-5 appeared to be specialized to the host and not related to an in vivo growth defect, as ΔT6SS-5 was fully virulent in mice lacking MyD88. Next we probed the role of the five systems in interbacterial interactions. From a group of 31 diverse bacteria, we identified several organisms that competed less effectively against wild-type B. thai than a strain lacking T6SS-1 function. Inactivation of T6SS-1 renders B. thai greatly more susceptible to cell contact-induced stasis by Pseudomonas putida, Pseudomonas fluorescens and Serratia proteamaculans—leaving it 100- to 1000-fold less fit than the wild-type in competition experiments with these organisms. Flow cell biofilm assays showed that T6S-dependent interbacterial interactions are likely relevant in the environment. B. thai cells lacking T6SS-1 were rapidly displaced in mixed biofilms with P. putida, whereas wild-type cells persisted and overran the competitor. Our data show that T6SSs within a single organism can have distinct functions in eukaryotic versus bacterial cell interactions. These systems are likely to be a decisive factor in the survival of bacterial cells of one species in intimate association with those of another, such as in polymicrobial communities present both in the environment and in many infections. PMID:20865170

Contribution of Innate Cortical Mechanisms to the Maturation of Orientation Selectivity in Parvalbumin Interneurons

PubMed Central

Figueroa Velez, Dario X.; Ellefsen, Kyle L.; Hathaway, Ethan R.; Carathedathu, Mathew C.

2017-01-01

The maturation of cortical parvalbumin-positive (PV) interneurons depends on the interaction of innate and experience-dependent factors. Dark-rearing experiments suggest that visual experience determines when broad orientation selectivity emerges in visual cortical PV interneurons. Here, using neural transplantation and in vivo calcium imaging of mouse visual cortex, we investigated whether innate mechanisms contribute to the maturation of orientation selectivity in PV interneurons. First, we confirmed earlier findings showing that broad orientation selectivity emerges in PV interneurons by 2 weeks after vision onset, ∼35 d after these cells are born. Next, we assessed the functional development of transplanted PV (tPV) interneurons. Surprisingly, 25 d after transplantation (DAT) and >2 weeks after vision onset, we found that tPV interneurons have not developed broad orientation selectivity. By 35 DAT, however, broad orientation selectivity emerges in tPV interneurons. Transplantation does not alter orientation selectivity in host interneurons, suggesting that the maturation of tPV interneurons occurs independently from their endogenous counterparts. Together, these results challenge the notion that the onset of vision solely determines when PV interneurons become broadly tuned. Our results reveal that an innate cortical mechanism contributes to the emergence of broad orientation selectivity in PV interneurons. SIGNIFICANCE STATEMENT Early visual experience and innate developmental programs interact to shape cortical circuits. Visual-deprivation experiments have suggested that the onset of visual experience determines when interneurons mature in the visual cortex. Here we used neuronal transplantation and cellular imaging of visual responses to investigate the maturation of parvalbumin-positive (PV) interneurons. Our results suggest that the emergence of broad orientation selectivity in PV interneurons is innately timed. PMID:28123018

Ds+ meson production at central rapidity in proton-proton collisions at √{ s} = 7 TeV

NASA Astrophysics Data System (ADS)

Abelev, B.; Adam, J.; Adamová, D.; Adare, A. M.; Aggarwal, M. M.; Aglieri Rinella, G.; Agocs, A. G.; Agostinelli, A.; Aguilar Salazar, S.; Ahammed, Z.; Ahmad, N.; Ahmad Masoodi, A.; Ahn, S. A.; Ahn, S. U.; Akindinov, A.; Aleksandrov, D.; Alessandro, B.; Alfaro Molina, R.; Alici, A.; Alkin, A.; Almaráz Aviña, E.; Alme, J.; Alt, T.; Altini, V.; Altinpinar, S.; Altsybeev, I.; Andrei, C.; Andronic, A.; Anguelov, V.; Anielski, J.; Anson, C.; Antičić, T.; Antinori, F.; Antonioli, P.; Aphecetche, L.; Appelshäuser, H.; Arbor, N.; Arcelli, S.; Arend, A.; Armesto, N.; Arnaldi, R.; Aronsson, T.; Arsene, I. C.; Arslandok, M.; Asryan, A.; Augustinus, A.; Averbeck, R.; Awes, T. C.; Äystö, J.; Azmi, M. D.; Bach, M.; Badalà, A.; Baek, Y. W.; Bailhache, R.; Bala, R.; Baldini Ferroli, R.; Baldisseri, A.; Baldit, A.; Baltasar Dos Santos Pedrosa, F.; Bán, J.; Baral, R. C.; Barbera, R.; Barile, F.; Barnaföldi, G. G.; Barnby, L. S.; Barret, V.; Bartke, J.; Basile, M.; Bastid, N.; Basu, S.; Bathen, B.; Batigne, G.; Batyunya, B.; Baumann, C.; Bearden, I. G.; Beck, H.; Belikov, I.; Bellini, F.; Bellwied, R.; Belmont-Moreno, E.; Bencedi, G.; Beole, S.; Berceanu, I.; Bercuci, A.; Berdnikov, Y.; Berenyi, D.; Bergognon, A. A. E.; Berzano, D.; Betev, L.; Bhasin, A.; Bhati, A. K.; Bhom, J.; Bianchi, L.; Bianchi, N.; Bianchin, C.; Bielčík, J.; Bielčíková, J.; Bilandzic, A.; Bjelogrlic, S.; Blanco, F.; Blanco, F.; Blau, D.; Blume, C.; Boccioli, M.; Bock, N.; Böttger, S.; Bogdanov, A.; Bøggild, H.; Bogolyubsky, M.; Boldizsár, L.; Bombara, M.; Book, J.; Borel, H.; Borissov, A.; Bose, S.; Bossú, F.; Botje, M.; Botta, E.; Boyer, B.; Braidot, E.; Braun-Munzinger, P.; Bregant, M.; Breitner, T.; Browning, T. A.; Broz, M.; Brun, R.; Bruna, E.; Bruno, G. E.; Budnikov, D.; Buesching, H.; Bufalino, S.; Busch, O.; Buthelezi, Z.; Caballero Orduna, D.; Caffarri, D.; Cai, X.; Caines, H.; Calvo Villar, E.; Camerini, P.; Canoa Roman, V.; Cara Romeo, G.; Carena, F.; Carena, W.; Carlin Filho, N.; Carminati, F.; Casanova Díaz, A.; Castillo Castellanos, J.; Castillo Hernandez, J. F.; Casula, E. A. R.; Catanescu, V.; Cavicchioli, C.; Ceballos Sanchez, C.; Cepila, J.; Cerello, P.; Chang, B.; Chapeland, S.; Charvet, J. L.; Chattopadhyay, S.; Chattopadhyay, S.; Chawla, I.; Cherney, M.; Cheshkov, C.; Cheynis, B.; Chibante Barroso, V.; Chinellato, D. D.; Chochula, P.; Chojnacki, M.; Choudhury, S.; Christakoglou, P.; Christensen, C. H.; Christiansen, P.; Chujo, T.; Chung, S. U.; Cicalo, C.; Cifarelli, L.; Cindolo, F.; Cleymans, J.; Coccetti, F.; Colamaria, F.; Colella, D.; Conesa Balbastre, G.; Conesa Del Valle, Z.; Constantin, P.; Contin, G.; Contreras, J. G.; Cormier, T. M.; Corrales Morales, Y.; Cortese, P.; Cortés Maldonado, I.; Cosentino, M. R.; Costa, F.; Cotallo, M. E.; Crescio, E.; Crochet, P.; Cruz Alaniz, E.; Cuautle, E.; Cunqueiro, L.; Dainese, A.; Dalsgaard, H. H.; Danu, A.; Das, I.; Das, D.; Das, K.; Dash, S.; Dash, A.; de, S.; de Barros, G. O. V.; de Caro, A.; de Cataldo, G.; de Cuveland, J.; de Falco, A.; de Gruttola, D.; Delagrange, H.; Deloff, A.; Demanov, V.; De Marco, N.; Dénes, E.; de Pasquale, S.; Deppman, A.; D Erasmo, G.; de Rooij, R.; Diaz Corchero, M. A.; di Bari, D.; Dietel, T.; di Giglio, C.; di Liberto, S.; di Mauro, A.; di Nezza, P.; Divià, R.; Djuvsland, Ø.; Dobrin, A.; Dobrowolski, T.; Domínguez, I.; Dönigus, B.; Dordic, O.; Driga, O.; Dubey, A. K.; Dubla, A.; Ducroux, L.; Dupieux, P.; Dutta Majumdar, A. K.; Dutta Majumdar, M. R.; Elia, D.; Emschermann, D.; Engel, H.; Erazmus, B.; Erdal, H. A.; Espagnon, B.; Estienne, M.; Esumi, S.; Evans, D.; Eyyubova, G.; Fabris, D.; Faivre, J.; Falchieri, D.; Fantoni, A.; Fasel, M.; Fearick, R.; Fedunov, A.; Fehlker, D.; Feldkamp, L.; Felea, D.; Fenton-Olsen, B.; Feofilov, G.; Fernández Téllez, A.; Ferretti, A.; Ferretti, R.; Festanti, A.; Figiel, J.; Figueredo, M. A. S.; Filchagin, S.; Finogeev, D.; Fionda, F. M.; Fiore, E. M.; Floris, M.; Foertsch, S.; Foka, P.; Fokin, S.; Fragiacomo, E.; Francescon, A.; Frankenfeld, U.; Fuchs, U.; Furget, C.; Fusco Girard, M.; Gaardhøje, J. J.; Gagliardi, M.; Gago, A.; Gallio, M.; Gangadharan, D. R.; Ganoti, P.; Garabatos, C.; Garcia-Solis, E.; Garishvili, I.; Gerhard, J.; Germain, M.; Geuna, C.; Gheata, M.; Gheata, A.; Ghidini, B.; Ghosh, P.; Gianotti, P.; Girard, M. R.; Giubellino, P.; Gladysz-Dziadus, E.; Glässel, P.; Gomez, R.; Ferreiro, E. G.; González-Trueba, L. H.; González-Zamora, P.; Gorbunov, S.; Goswami, A.; Gotovac, S.; Grabski, V.; Graczykowski, L. K.; Grajcarek, R.; Grelli, A.; Grigoras, C.; Grigoras, A.; Grigoriev, V.; Grigoryan, S.; Grigoryan, A.; Grinyov, B.; Grion, N.; Gros, P.; Grosse-Oetringhaus, J. F.; Grossiord, J.-Y.; Grosso, R.; Guber, F.; Guernane, R.; Guerra Gutierrez, C.; Guerzoni, B.; Guilbaud, M.; Gulbrandsen, K.; Gunji, T.; Gupta, R.; Gupta, A.; Gutbrod, H.; Haaland, Ø.; Hadjidakis, C.; Haiduc, M.; Hamagaki, H.; Hamar, G.; Han, B. H.; Hanratty, L. D.; Hansen, A.; Harmanová-Tóthová, Z.; Harris, J. W.; Hartig, M.; Hasegan, D.; Hatzifotiadou, D.; Hayrapetyan, A.; Heckel, S. T.; Heide, M.; Helstrup, H.; Herghelegiu, A.; Herrera Corral, G.; Herrmann, N.; Hess, B. A.; Hetland, K. F.; Hicks, B.; Hille, P. T.; Hippolyte, B.; Horaguchi, T.; Hori, Y.; Hristov, P.; Hřivnáčová, I.; Huang, M.; Humanic, T. J.; Hwang, D. S.; Ichou, R.; Ilkaev, R.; Ilkiv, I.; Inaba, M.; Incani, E.; Innocenti, G. M.; Innocenti, P. G.; Ippolitov, M.; Irfan, M.; Ivan, C.; Ivanov, M.; Ivanov, A.; Ivanov, V.; Ivanytskyi, O.; Jacobs, P. M.; Jang, H. J.; Janik, R.; Janik, M. A.; Jayarathna, P. H. S. Y.; Jena, S.; Jha, D. M.; Jimenez Bustamante, R. T.; Jirden, L.; Jones, P. G.; Jung, H.; Jusko, A.; Kaidalov, A. B.; Kakoyan, V.; Kalcher, S.; Kaliňák, P.; Kalliokoski, T.; Kalweit, A.; Kang, J. H.; Kaplin, V.; Karasu Uysal, A.; Karavichev, O.; Karavicheva, T.; Karpechev, E.; Kazantsev, A.; Kebschull, U.; Keidel, R.; Khan, P.; Khan, M. M.; Khan, S. A.; Khanzadeev, A.; Kharlov, Y.; Kileng, B.; Kim, M.; Kim, D. J.; Kim, D. W.; Kim, J. H.; Kim, J. S.; Kim, T.; Kim, M.; Kim, S. H.; Kim, S.; Kim, B.; Kirsch, S.; Kisel, I.; Kiselev, S.; Kisiel, A.; Klay, J. L.; Klein, J.; Klein-Bösing, C.; Kliemant, M.; Kluge, A.; Knichel, M. L.; Knospe, A. G.; Koch, K.; Köhler, M. K.; Kollegger, T.; Kolojvari, A.; Kondratiev, V.; Kondratyeva, N.; Konevskikh, A.; Korneev, A.; Kour, R.; Kowalski, M.; Kox, S.; Koyithatta Meethaleveedu, G.; Kral, J.; Králik, I.; Kramer, F.; Kraus, I.; Krawutschke, T.; Krelina, M.; Kretz, M.; Krivda, M.; Krizek, F.; Krus, M.; Kryshen, E.; Krzewicki, M.; Kucheriaev, Y.; Kugathasan, T.; Kuhn, C.; Kuijer, P. G.; Kulakov, I.; Kumar, J.; Kurashvili, P.; Kurepin, A. B.; Kurepin, A.; Kuryakin, A.; Kushpil, S.; Kushpil, V.; Kvaerno, H.; Kweon, M. J.; Kwon, Y.; Ladrón de Guevara, P.; Lakomov, I.; Langoy, R.; La Pointe, S. L.; Lara, C.; Lardeux, A.; La Rocca, P.; Lazzeroni, C.; Lea, R.; Le Bornec, Y.; Lechman, M.; Lee, K. S.; Lee, G. R.; Lee, S. C.; Lefèvre, F.; Lehnert, J.; Leistam, L.; Lenhardt, M.; Lenti, V.; León, H.; Leoncino, M.; León Monzón, I.; León Vargas, H.; Lévai, P.; Lien, J.; Lietava, R.; Lindal, S.; Lindenstruth, V.; Lippmann, C.; Lisa, M. A.; Liu, L.; Loggins, V. R.; Loginov, V.; Lohn, S.; Lohner, D.; Loizides, C.; Loo, K. K.; Lopez, X.; López Torres, E.; Løvhøiden, G.; Lu, X.-G.; Luettig, P.; Lunardon, M.; Luo, J.; Luparello, G.; Luquin, L.; Luzzi, C.; Ma, K.; Ma, R.; Madagodahettige-Don, D. M.; Maevskaya, A.; Mager, M.; Mahapatra, D. P.; Maire, A.; Malaev, M.; Maldonado Cervantes, I.; Malinina, L.; Mal'Kevich, D.; Malzacher, P.; Mamonov, A.; Manceau, L.; Mangotra, L.; Manko, V.; Manso, F.; Manzari, V.; Mao, Y.; Marchisone, M.; Mareš, J.; Margagliotti, G. V.; Margotti, A.; Marín, A.; Marin Tobon, C. A.; Markert, C.; Martashvili, I.; Martinengo, P.; Martínez, M. I.; Martínez Davalos, A.; Martínez García, G.; Martynov, Y.; Mas, A.; Masciocchi, S.; Masera, M.; Masoni, A.; Massacrier, L.; Mastroserio, A.; Matthews, Z. L.; Matyja, A.; Mayer, C.; Mazer, J.; Mazzoni, M. A.; Meddi, F.; Menchaca-Rocha, A.; Mercado Pérez, J.; Meres, M.; Miake, Y.; Milano, L.; Milosevic, J.; Mischke, A.; Mishra, A. N.; Miśkowiec, D.; Mitu, C.; Mlynarz, J.; Mohanty, B.; Molnar, L.; Montaño Zetina, L.; Monteno, M.; Montes, E.; Moon, T.; Morando, M.; Moreira de Godoy, D. A.; Moretto, S.; Morsch, A.; Muccifora, V.; Mudnic, E.; Muhuri, S.; Mukherjee, M.; Müller, H.; Munhoz, M. G.; Musa, L.; Musso, A.; Nandi, B. K.; Nania, R.; Nappi, E.; Nattrass, C.; Naumov, N. P.; Navin, S.; Nayak, T. K.; Nazarenko, S.; Nazarov, G.; Nedosekin, A.; Nicassio, M.; Niculescu, M.; Nielsen, B. S.; Niida, T.; Nikolaev, S.; Nikolic, V.; Nikulin, S.; Nikulin, V.; Nilsen, B. S.; Nilsson, M. S.; Noferini, F.; Nomokonov, P.; Nooren, G.; Novitzky, N.; Nyanin, A.; Nyatha, A.; Nygaard, C.; Nystrand, J.; Ochirov, A.; Oeschler, H.; Oh, S.; Oh, S. K.; Oleniacz, J.; Oppedisano, C.; Ortiz Velasquez, A.; Ortona, G.; Oskarsson, A.; Ostrowski, P.; Otwinowski, J.; Oyama, K.; Ozawa, K.; Pachmayer, Y.; Pachr, M.; Padilla, F.; Pagano, P.; Paić, G.; Painke, F.; Pajares, C.; Pal, S. K.; Palaha, A.; Palmeri, A.; Papikyan, V.; Pappalardo, G. S.; Park, W. J.; Passfeld, A.; Pastirčák, B.; Patalakha, D. I.; Paticchio, V.; Pavlinov, A.; Pawlak, T.; Peitzmann, T.; Pereira da Costa, H.; Pereira de Oliveira Filho, E.; Peresunko, D.; Pérez Lara, C. E.; Perez Lezama, E.; Perini, D.; Perrino, D.; Peryt, W.; Pesci, A.; Peskov, V.; Pestov, Y.; Petráček, V.; Petran, M.; Petris, M.; Petrov, P.; Petrovici, M.; Petta, C.; Piano, S.; Piccotti, A.; Pikna, M.; Pillot, P.; Pinazza, O.; Pinsky, L.; Pitz, N.; Piyarathna, D. B.; Planinic, M.; Płoskoń, M.; Pluta, J.; Pocheptsov, T.; Pochybova, S.; Podesta-Lerma, P. L. M.; Poghosyan, M. G.; Polák, K.; Polichtchouk, B.; Pop, A.; Porteboeuf-Houssais, S.; Pospíšil, V.; Potukuchi, B.; Prasad, S. K.; Preghenella, R.; Prino, F.; Pruneau, C. A.; Pshenichnov, I.; Puchagin, S.; Puddu, G.; Pulvirenti, A.; Punin, V.; Putiš, M.; Putschke, J.; Quercigh, E.; Qvigstad, H.; Rachevski, A.; Rademakers, A.; Räihä, T. S.; Rak, J.; Rakotozafindrabe, A.; Ramello, L.; Ramírez Reyes, A.; Raniwala, S.; Raniwala, R.; Räsänen, S. S.; Rascanu, B. T.; Rathee, D.; Read, K. F.; Real, J. S.; Redlich, K.; Reichelt, P.; Reicher, M.; Renfordt, R.; Reolon, A. R.; Reshetin, A.; Rettig, F.; Revol, J.-P.; Reygers, K.; Riccati, L.; Ricci, R. A.; Richert, T.; Richter, M.; Riedler, P.; Riegler, W.; Riggi, F.; Rodrigues Fernandes Rabacal, B.; Rodríguez Cahuantzi, M.; Rodriguez Manso, A.; Røed, K.; Rohr, D.; Röhrich, D.; Romita, R.; Ronchetti, F.; Rosnet, P.; Rossegger, S.; Rossi, A.; Roy, P.; Roy, C.; Rubio Montero, A. J.; Rui, R.; Russo, R.; Ryabinkin, E.; Rybicki, A.; Sadovsky, S.; Šafařík, K.; Sahoo, R.; Sahu, P. K.; Saini, J.; Sakaguchi, H.; Sakai, S.; Sakata, D.; Salgado, C. A.; Salzwedel, J.; Sambyal, S.; Samsonov, V.; Sanchez Castro, X.; Šándor, L.; Sandoval, A.; Sano, M.; Sano, S.; Santo, R.; Santoro, R.; Sarkamo, J.; Scapparone, E.; Scarlassara, F.; Scharenberg, R. P.; Schiaua, C.; Schicker, R.; Schmidt, H. R.; Schmidt, C.; Schreiner, S.; Schuchmann, S.; Schukraft, J.; Schutz, Y.; Schwarz, K.; Schweda, K.; Scioli, G.; Scomparin, E.; Scott, P. A.; Scott, R.; Segato, G.; Selyuzhenkov, I.; Senyukov, S.; Seo, J.; Serci, S.; Serradilla, E.; Sevcenco, A.; Shabetai, A.; Shabratova, G.; Shahoyan, R.; Sharma, N.; Sharma, S.; Rohni, S.; Shigaki, K.; Shimomura, M.; Shtejer, K.; Sibiriak, Y.; Siciliano, M.; Sicking, E.; Siddhanta, S.; Siemiarczuk, T.; Silvermyr, D.; Silvestre, C.; Simatovic, G.; Simonetti, G.; Singaraju, R.; Singh, R.; Singha, S.; Singhal, V.; Sinha, T.; Sinha, B. C.; Sitar, B.; Sitta, M.; Skaali, T. B.; Skjerdal, K.; Smakal, R.; Smirnov, N.; Snellings, R. J. M.; Søgaard, C.; Soltz, R.; Son, H.; Song, J.; Song, M.; Soos, C.; Soramel, F.; Sputowska, I.; Spyropoulou-Stassinaki, M.; Srivastava, B. K.; Stachel, J.; Stan, I.; Stan, I.; Stefanek, G.; Steinpreis, M.; Stenlund, E.; Steyn, G.; Stiller, J. H.; Stocco, D.; Stolpovskiy, M.; Strabykin, K.; Strmen, P.; Suaide, A. A. P.; Subieta Vásquez, M. A.; Sugitate, T.; Suire, C.; Sukhorukov, M.; Sultanov, R.; Šumbera, M.; Susa, T.; Symons, T. J. M.; Szanto de Toledo, A.; Szarka, I.; Szczepankiewicz, A.; Szostak, A.; Szymański, M.; Takahashi, J.; Tapia Takaki, J. D.; Tauro, A.; Tejeda Muñoz, G.; Telesca, A.; Terrevoli, C.; Thäder, J.; Thomas, D.; Tieulent, R.; Timmins, A. R.; Tlusty, D.; Toia, A.; Torii, H.; Toscano, L.; Trubnikov, V.; Truesdale, D.; Trzaska, W. H.; Tsuji, T.; Tumkin, A.; Turrisi, R.; Tveter, T. S.; Ulery, J.; Ullaland, K.; Ulrich, J.; Uras, A.; Urbán, J.; Urciuoli, G. M.; Usai, G. L.; Vajzer, M.; Vala, M.; Valencia Palomo, L.; Vallero, S.; Vande Vyvre, P.; van Leeuwen, M.; Vannucci, L.; Vargas, A.; Varma, R.; Vasileiou, M.; Vasiliev, A.; Vechernin, V.; Veldhoen, M.; Venaruzzo, M.; Vercellin, E.; Vergara, S.; Vernet, R.; Verweij, M.; Vickovic, L.; Viesti, G.; Vikhlyantsev, O.; Vilakazi, Z.; Villalobos Baillie, O.; Vinogradov, Y.; Vinogradov, A.; Vinogradov, L.; Virgili, T.; Viyogi, Y. P.; Vodopyanov, A.; Voloshin, S.; Voloshin, K.; Volpe, G.; von Haller, B.; Vranic, D.; Øvrebekk, G.; Vrláková, J.; Vulpescu, B.; Vyushin, A.; Wagner, V.; Wagner, B.; Wan, R.; Wang, Y.; Wang, M.; Wang, D.; Wang, Y.; Watanabe, K.; Weber, M.; Wessels, J. P.; Westerhoff, U.; Wiechula, J.; Wikne, J.; Wilde, M.; Wilk, A.; Wilk, G.; Williams, M. C. S.; Windelband, B.; Xaplanteris Karampatsos, L.; Yaldo, C. G.; Yamaguchi, Y.; Yang, S.; Yang, H.; Yasnopolskiy, S.; Yi, J.; Yin, Z.; Yoo, I.-K.; Yoon, J.; Yu, W.; Yuan, X.; Yushmanov, I.; Zaccolo, V.; Zach, C.; Zampolli, C.; Zaporozhets, S.; Zarochentsev, A.; Závada, P.; Zaviyalov, N.; Zbroszczyk, H.; Zelnicek, P.; Zgura, I. S.; Zhalov, M.; Zhang, H.; Zhang, X.; Zhou, D.; Zhou, Y.; Zhou, F.; Zhu, J.; Zhu, X.; Zhu, J.; Zichichi, A.; Zimmermann, A.; Zinovjev, G.; Zoccarato, Y.; Zynovyev, M.; Zyzak, M.; Alice Collaboration

2012-12-01

The pT-differential inclusive production cross section of the prompt charm-strange meson Ds+ in the rapidity range | y | < 0.5 was measured in proton-proton collisions at √{ s} = 7 TeV at the LHC using the ALICE detector. The analysis was performed on a data sample of 2.98 ×108 events collected with a minimum-bias trigger. The corresponding integrated luminosity is Lint = 4.8 nb-1. Reconstructing the decay Ds+ → ϕπ+, with ϕ →K-K+, and its charge conjugate, about 480 Ds± mesons were counted, after selection cuts, in the transverse momentum range 2

Laboratory Studies of FeO and NiO Chemiluminescence

NASA Astrophysics Data System (ADS)

Kalogerakis, K. S.; Bartlett, N. C.; Copeland, R. A.; Slanger, T. G.

2013-12-01

Although the terrestrial nightglow spectrum has been studied for over a century, new identifications of spectral features continue to be made. Recently, FeO* continuum emissions in the mesosphere were identified by comparison of results from the OSIRIS spectrometer to existing laboratory spectra [1]. This discovery has sparked a renewal of interest in the reactions of meteoric metals with mesospheric gases [2,3], and has motivated the current study. We report laboratory-based chemiluminescence spectra from the reactions Fe + O3 and Ni + O3 produced under various conditions. Iron and nickel vapor was prepared in a vacuum cell using laser ablation at 248 and 800 nm in the presence of ozone. Emission spectra from FeO* and NiO* were recorded in the region of 450-700 nm using a commercial fiber-coupled spectrometer and compared to previous results using different methods. Knowledge of the excited-state production efficiency of Fe + O3 → FeO* + O2 and the analogous reaction with Ni is critical in modeling upper atmospheric dynamics of meteoric metal layers. The only relevant experimental study in the literature for iron oxide is from West and Broida [4], who reported a yield of approximately 2% at around 1 Torr, in stark contrast with the 100% efficiency used in relevant model calculations [5]. This work was supported by the National Science Foundation's Aeronomy Program under grant AGS-0637433. References 1. W.F.J. Evans, R.L. Gattinger, T.G. Slanger, D.V. Saran, D.A. Degenstein, and E.J. Llewellyn, Geophys. Res. Lett., 37, L22105 (2010). 2. D.V. Saran, T.G. Slanger, W. Feng, and J.M.C. Plane, J. Geophys. Res. 116, D12303 (2011). 3. R.L. Gattinger, W.F.J. Evans, and E.J. Llewellyn, Canadian Journal of Physics 89, 869 (2011). 4. J.B. West and H.P. Broida, J. Chem. Phys. 62, 2566 (1975 ). 5. C.S. Gardner, J.M.C. Plane, W.L. Pan, T. Vondrak, B.J. Murray, and X.Z. Chu, J. Geophys. Res. 110, D10302 (2005).

Structural changes induced by binding of the high-mobility group I protein to a mouse satellite DNA sequence.

PubMed Central

Slama-Schwok, A; Zakrzewska, K; Léger, G; Leroux, Y; Takahashi, M; Käs, E; Debey, P

2000-01-01

Using spectroscopic methods, we have studied the structural changes induced in both protein and DNA upon binding of the High-Mobility Group I (HMG-I) protein to a 21-bp sequence derived from mouse satellite DNA. We show that these structural changes depend on the stoichiometry of the protein/DNA complexes formed, as determined by Job plots derived from experiments using pyrene-labeled duplexes. Circular dichroism and melting temperature experiments extended in the far ultraviolet range show that while native HMG-I is mainly random coiled in solution, it adopts a beta-turn conformation upon forming a 1:1 complex in which the protein first binds to one of two dA.dT stretches present in the duplex. HMG-I structure in the 1:1 complex is dependent on the sequence of its DNA target. A 3:1 HMG-I/DNA complex can also form and is characterized by a small increase in the DNA natural bend and/or compaction coupled to a change in the protein conformation, as determined from fluorescence resonance energy transfer (FRET) experiments. In addition, a peptide corresponding to an extended DNA-binding domain of HMG-I induces an ordered condensation of DNA duplexes. Based on the constraints derived from pyrene excimer measurements, we present a model of these nucleated structures. Our results illustrate an extreme case of protein structure induced by DNA conformation that may bear on the evolutionary conservation of the DNA-binding motifs of HMG-I. We discuss the functional relevance of the structural flexibility of HMG-I associated with the nature of its DNA targets and the implications of the binding stoichiometry for several aspects of chromatin structure and gene regulation. PMID:10777751

Integrated Social and QoS Trust-Based Routing in Mobile Ad Hoc Delay Tolerant Networks

DTIC Science & Technology

2010-11-15

d-connectivity, honesty, or unselfishness) with: encounter*,. , A ^// m = / (3) {•p ounter,x r. , . .-, ( Ti x m (t), ifm =j ^indirect. X, T...take into account node »’ s belief in node m in the calculation ofT(jreet’ x(t + At). This models the decay of trust as trust is derived from a distant...directly based on node /’ s past experiences with node m up to time t + At, including the current encounter. Taking the fact that /? a + /?2 = 1, we obtain

Comparison of image features calculated in different dimensions for computer-aided diagnosis of lung nodules

NASA Astrophysics Data System (ADS)

Xu, Ye; Lee, Michael C.; Boroczky, Lilla; Cann, Aaron D.; Borczuk, Alain C.; Kawut, Steven M.; Powell, Charles A.

2009-02-01

Features calculated from different dimensions of images capture quantitative information of the lung nodules through one or multiple image slices. Previously published computer-aided diagnosis (CADx) systems have used either twodimensional (2D) or three-dimensional (3D) features, though there has been little systematic analysis of the relevance of the different dimensions and of the impact of combining different dimensions. The aim of this study is to determine the importance of combining features calculated in different dimensions. We have performed CADx experiments on 125 pulmonary nodules imaged using multi-detector row CT (MDCT). The CADx system computed 192 2D, 2.5D, and 3D image features of the lesions. Leave-one-out experiments were performed using five different combinations of features from different dimensions: 2D, 3D, 2.5D, 2D+3D, and 2D+3D+2.5D. The experiments were performed ten times for each group. Accuracy, sensitivity and specificity were used to evaluate the performance. Wilcoxon signed-rank tests were applied to compare the classification results from these five different combinations of features. Our results showed that 3D image features generate the best result compared with other combinations of features. This suggests one approach to potentially reducing the dimensionality of the CADx data space and the computational complexity of the system while maintaining diagnostic accuracy.

Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex.

PubMed

Hagberg, Gisela E; Mamedov, Ilgar; Power, Anthony; Beyerlein, Michael; Merkle, Hellmut; Kiselev, Valerij G; Dhingra, Kirti; Kubìček, Vojtĕch; Angelovski, Goran; Logothetis, Nikos K

2014-01-01

Calcium-sensitive MRI contrast agents can only yield quantitative results if the agent concentration in the tissue is known. The agent concentration could be determined by diffusion modeling, if relevant parameters were available. We have established an MRI-based method capable of determining diffusion properties of conventional and calcium-sensitive agents. Simulations and experiments demonstrate that the method is applicable both for conventional contrast agents with a fixed relaxivity value and for calcium-sensitive contrast agents. The full pharmacokinetic time-course of gadolinium concentration estimates was observed by MRI before, during and after intracerebral administration of the agent, and the effective diffusion coefficient D* was determined by voxel-wise fitting of the solution to the diffusion equation. The method yielded whole brain coverage with a high spatial and temporal sampling. The use of two types of MRI sequences for sampling of the diffusion time courses was investigated: Look-Locker-based quantitative T(1) mapping, and T(1) -weighted MRI. The observation times of the proposed MRI method is long (up to 20 h) and consequently the diffusion distances covered are also long (2-4 mm). Despite this difference, the D* values in vivo were in agreement with previous findings using optical measurement techniques, based on observation times of a few minutes. The effective diffusion coefficient determined for the calcium-sensitive contrast agents may be used to determine local tissue concentrations and to design infusion protocols that maintain the agent concentration at a steady state, thereby enabling quantitative sensing of the local calcium concentration. Copyright © 2014 John Wiley & Sons, Ltd.

Accelerated time-resolved three-dimensional MR velocity mapping of blood flow patterns in the aorta using SENSE and k-t BLAST.

PubMed

Stadlbauer, Andreas; van der Riet, Wilma; Crelier, Gerard; Salomonowitz, Erich

2010-07-01

To assess the feasibility and potential limitations of the acceleration techniques SENSE and k-t BLAST for time-resolved three-dimensional (3D) velocity mapping of aortic blood flow. Furthermore, to quantify differences in peak velocity versus heart phase curves. Time-resolved 3D blood flow patterns were investigated in eleven volunteers and two patients suffering from aortic diseases with accelerated PC-MR sequences either in combination with SENSE (R=2) or k-t BLAST (6-fold). Both sequences showed similar data acquisition times and hence acceleration efficiency. Flow-field streamlines were calculated and visualized using the GTFlow software tool in order to reconstruct 3D aortic blood flow patterns. Differences between the peak velocities from single-slice PC-MRI experiments using SENSE 2 and k-t BLAST 6 were calculated for the whole cardiac cycle and averaged for all volunteers. Reconstruction of 3D flow patterns in volunteers revealed attenuations in blood flow dynamics for k-t BLAST 6 compared to SENSE 2 in terms of 3D streamlines showing fewer and less distinct vortices and reduction in peak velocity, which is caused by temporal blurring. Solely by time-resolved 3D MR velocity mapping in combination with SENSE detected pathologic blood flow patterns in patients with aortic diseases. For volunteers, we found a broadening and flattering of the peak velocity versus heart phase diagram between the two acceleration techniques, which is an evidence for the temporal blurring of the k-t BLAST approach. We demonstrated the feasibility of SENSE and detected potential limitations of k-t BLAST when used for time-resolved 3D velocity mapping. The effects of higher k-t BLAST acceleration factors have to be considered for application in 3D velocity mapping. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Zn influence on the plasticity of Cdo{0.96}Zn{0.04}Te

NASA Astrophysics Data System (ADS)

Imhoff, D.; Zozime, A.; Triboulet, R.

1991-11-01

Compression tests were performed on CdTe and Cd{0.96}Zn{0.04}Te to elucidate the mechanism through which Zn inhibits dislocation formation and motion during CdTe crystal growth, thus leading to a decreasing of the dislocation density. Uniaxial deformation experiments performed with CdTe and CdZnTe at constant strain rate within a wide temperature range (0. 14;T_m le T le 0.87;T_m,;T_m = 1 365; K), have revealed a strong hardening effect of Zn within the whole temperature range. They also showed in CdZnTe a Portevin Le Chatelier effect between 770 K and 920 K confirmed by static strain aging experiments. Critical resolved shear stress (C.R.S.S.) values at T = 195; K and static strain aging results with CdZnTe point to size effect as the dominant interaction between Zn and dislocations. Thermal activation parameters were estimated in both materials. La déformation plastique a été utilisée comme approche des mécanismes par lesquels le zinc entrave le mouvement des dislocations au cours du processus de croissance cristalline de CdTe massif, réduisant ainsi la densité de dislocations. Les expériences de compression uniaxiale à vitesse constante, réalisées dans CdTe et CdZnTe entre 0,14 T_f et 0,87 T_f ont montré que le zinc est responsable d'un fort durcissement sur tout le domaine de températures étudié. Les expériences de déformation dans CdZnTe ont mis en évidence un phénomène du type Portevin Le Chatelier entre 770 K et 920 K, confirmé par des expériences de vieillissement statique. Les valeurs de scission critique tau_c à 195 K et les résultats des expériences de vieillissement statique dans CdZnTe sont compatibles avec un effet de taille dominant pour les interactions Zndislocations. Les paramètres d'activation thermique ont été estimés dans les deux matériaux.

Acquisition Research: Creating Synergy for Informed Change. Proceedings of the Annual Acquisition Research Symposium (4th) Held in Monterey, California on 16-17 May 2007. Volume 2: Thursday Sessions

DTIC Science & Technology

2007-04-30

faculty research and student classroom instruction has been exceptional with many relevant and current instructional materials emerging from research...products, thus enhancing the student educational experience. Faculty are “refreshed” in defense-relevant subject matter, and students are better...DoD, industry and government leaders in acquisition, supervises student MBA projects and conducts guest lectures and seminars. Before serving at NPS

Toward measurements of volatile behavior at realistic pressure and temperature conditions in planetary deep interiors. (Invited)

NASA Astrophysics Data System (ADS)

McWilliams, R. S.

2013-12-01

Laboratory studies of volatiles at high pressure are constantly challenged to achieve conditions directly relevant to planets. While dynamic compression experiments are confined to adiabatic pathways that frequently exceed relevant temperatures due to the low densities and bulk moduli of volatile samples, static compression experiments are often complicated by sample reactivity and mobility before reaching relevant temperatures. By combining the speed of dynamic compression with the flexibility of experimental path afforded by static compression, optical spectroscopy measurements in volatiles such as H, N, and Ar have been demonstrated at previously-unexplored planetary temperature (up to 11,000 K) and pressure (up to 150 GPa). These optical data characterize the electronic properties of extreme states and have implications for bonding, transport, and mixing behavior in volatiles within planets. This work was conducted in collaboration with D.A. Dalton and A.F. Goncharov (Carnegie Institution of Washington) and M.F. Mahmood (Howard University).

Change of translational-rotational coupling in liquids revealed by field-cycling {sup 1}H NMR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meier, R.; Schneider, E.; Rössler, E. A.

2015-01-21

Applying the field-cycling nuclear magnetic resonance technique, the frequency dependence of the {sup 1}H spin-lattice relaxation rate, R{sub 1}(ω)=T{sub 1}{sup −1}(ω), is measured for propylene glycol (PG) which is increasingly diluted with deuterated chloroform. A frequency range of 10 kHz–20 MHz and a broad temperature interval from 220 to about 100 K are covered. The results are compared to those of experiments, where glycerol and o-terphenyl are diluted with their deuterated counter-part. Reflecting intra- as well as intermolecular relaxation, the dispersion curves R{sub 1}(ω,x) (x denotes mole fraction PG) allow to extract the rotational time constant τ{sub rot}(T, x) andmore » the self-diffusion coefficient D(T, x) in a single experiment. The Stokes-Einstein-Debye (SED) relation is tested in terms of the quantity D(T, x) τ{sub rot}(T, x) which provides a measure of an effective hydrodynamic radius or equivalently of the spectral separation of the translational and the rotational relaxation contribution. In contrast to o-terphenyl, glycerol and PG show a spectral separation much larger than suggested by the SED relation. In the case of PG/chloroform mixtures, not only an acceleration of the PG dynamics is observed with increasing dilution but also the spectral separation of rotational and translational relaxation contributions continuously decreases. Finally, following a behavior similar to that of o-terphenyl already at about x = 0.6; i.e., while D(T, x) τ{sub rot}(T, x) in the mixture is essentially temperature independent, it strongly increases with x signaling thus a change of translational-rotational coupling. This directly reflects the dissolution of the hydrogen-bond network and thus a change of solution structure.« less

Application of Curved MPR Algorithm to High Resolution 3 Dimensional T2 Weighted CISS Images for Virtual Uncoiling of Membranous Cochlea as an Aid for Cochlear Morphometry.

PubMed

Kumar, Joish Upendra; Kavitha, Y

2017-02-01

With the use of various surgical techniques, types of implants, the preoperative assessment of cochlear dimensions is becoming increasingly relevant prior to cochlear implantation. High resolution CISS protocol MRI gives a better assessment of membranous cochlea, cochlear nerve, and membranous labyrinth. Curved Multiplanar Reconstruction (MPR) algorithm provides better images that can be used for measuring dimensions of membranous cochlea. To ascertain the value of curved multiplanar reconstruction algorithm in high resolution 3-Dimensional T2 Weighted Gradient Echo Constructive Interference Steady State (3D T2W GRE CISS) imaging for accurate morphometry of membranous cochlea. Fourteen children underwent MRI for inner ear assessment. High resolution 3D T2W GRE CISS sequence was used to obtain images of cochlea. Curved MPR reconstruction algorithm was used to virtually uncoil the membranous cochlea on the volume images and cochlear measurements were done. Virtually uncoiled images of membranous cochlea of appropriate resolution were obtained from the volume data obtained from the high resolution 3D T2W GRE CISS images, after using curved MPR reconstruction algorithm mean membranous cochlear length in the children was 27.52 mm. Maximum apical turn diameter of membranous cochlea was 1.13 mm, mid turn diameter was 1.38 mm, basal turn diameter was 1.81 mm. Curved MPR reconstruction algorithm applied to CISS protocol images facilitates in getting appropriate quality images of membranous cochlea for accurate measurements.

Analyse Pharmaceutique de la prescription des antibiotiques au service des brules et chirurgie plastique de l'Hopital Militaire d'Instruction Mohammed V, Maroc

PubMed Central

Benziane, H.; Karfo, R.; Siah, S.; Taoufik, J.

2011-01-01

Summary L'infection est longtemps restée la principale cause de mortalité chez le brûlé grave. Ce travail a pour but d'évaluer la prescription des antibiotiques dans notre Service des Brûlés et Chirurgie Plastique, au regard du dossier d'autorisation de mise sur le marché (Résumé des caractéristiques du produit). Tous les patients sous antibiothérapie, au Service des Brûlés et Chirurgie Plastique de l'Hôpital Militaire d'Instruction Mohammed V de Rabat, Maroc, durant la période janvier 2008/mai 2009, ont été inclus. Il s'agit d'une étude rétrospective qui a analysé 41 dossiers de patients. Les antibiotiques utilisés par le service appartiennent à différentes familles. Les plus utilisés sont les bêta-lactamines (65%), glycopeptides (10,5%), aminosides (9%), quinolones (7%) et colistine (4,3%), avec 4,2% pour les autres classes d'antibiotiques (métronidazole 500 mg en perfusion, fluconazole injectable 100 mg/50 ml, rifampicine 600 mg en perfusion, sulfadiazine argentique crème, acide fusidique 2% crème, etc.); 70% des prescriptions sont non documentées. La voie injectable est prépondérante (89%). En tout, 227 ordonnances nominatives d'antibiothérapie ont été analysées: la posologie et les contre-indications ont été respectées par rapport à l'autorisation de mise sur le marché. Trois cas d'interactions médicamenteuses ont été relevés (fluconazole-rifampicine, fluconazole-Saccharomyces boulardii, amikacine-vancomycine). Ce constat montre l'importance de l'analyse pharmaceutique des prescriptions des antibiotiques dans un service utilisant des antibiotiques de la réserve hospitalière, donc actifs mais très toxiques. PMID:22396670

Increased levels of Dickkopf-1 are indicative of Wnt/β-catenin downregulation and lower osteoblast signaling in children and adolescents with type 1 diabetes mellitus, contributing to lower bone mineral density.

PubMed

Tsentidis, C; Gourgiotis, D; Kossiva, L; Marmarinos, A; Doulgeraki, A; Karavanaki, K

2017-03-01

Higher levels of Dickkopf-1, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, could be indicative of downregulated Wnt system, with possible lower osteoblast activation and higher osteoclast signaling in type 1 diabetes mellitus children and adolescents. Dickkopf-1 could significantly contribute to diabetes osteopathy. Increased fracture risk and elevated Dickkopf-1 levels, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, have been documented in adult patients with type 2 diabetes mellitus (T2D), while no relevant data exist on childhood type 1 diabetes (T1D). Our aim was to study plasma Dickkopf-1 distribution in children and adolescents with T1D and to correlate Dickkopf-1 with metabolic bone markers and bone mineral density (BMD). We evaluated 40 children and adolescents with T1D (mean ± SD age 13.04 ± 3.53 years, T1D duration 5.15 ± 3.33 years) and 40 healthy age-matched and gender-matched controls (age 12.99 ± 3.3 years). Dickkopf-1 and bone metabolic markers were measured, while total body and lumbar spine BMD were evaluated with dual-energy X-ray absorptiometry (DXA). Dickkopf-1 demonstrated a Gaussian distribution, with higher levels in T1D patients (13.56 ± 5.34 vs 11.35 ± 3.76 pmol/L, p = 0.024). Higher values were found in boys and in prepubertal children. Dickkopf-1 correlated positively with osteoprotegerin and fasting glucose in patients, while positive correlation with sclerostin and total soluble receptor activator of nuclear factor-kappaB ligand (s-RANKL) was found in controls. Positive correlations with C-telopeptide cross-links (CTX), osteocalcin, alkaline phosphatase, phosphate, and insulin-like growth factor 1 (IGF1) were documented in both groups. Lumbar spine Z-score was positively associated with Dickkopf-1 in controls, while a negative trend was found in patients. Higher levels of Dickkopf-1 could indicate a downregulated Wnt/β-catenin system with possible lower osteoblast activation and higher osteoclast signaling in T1D children and adolescents. Dickkopf-1 could possibly be a significant contributor of T1D osteopathy. Future therapies could focus on Wnt/β-catenin metabolic pathway.

Anomalous scaling of a passive scalar advected by the Navier-Stokes velocity field: two-loop approximation.

PubMed

Adzhemyan, L Ts; Antonov, N V; Honkonen, J; Kim, T L

2005-01-01

The field theoretic renormalization group and operator-product expansion are applied to the model of a passive scalar quantity advected by a non-Gaussian velocity field with finite correlation time. The velocity is governed by the Navier-Stokes equation, subject to an external random stirring force with the correlation function proportional to delta(t- t')k(4-d-2epsilon). It is shown that the scalar field is intermittent already for small epsilon, its structure functions display anomalous scaling behavior, and the corresponding exponents can be systematically calculated as series in epsilon. The practical calculation is accomplished to order epsilon2 (two-loop approximation), including anisotropic sectors. As for the well-known Kraichnan rapid-change model, the anomalous scaling results from the existence in the model of composite fields (operators) with negative scaling dimensions, identified with the anomalous exponents. Thus the mechanism of the origin of anomalous scaling appears similar for the Gaussian model with zero correlation time and the non-Gaussian model with finite correlation time. It should be emphasized that, in contrast to Gaussian velocity ensembles with finite correlation time, the model and the perturbation theory discussed here are manifestly Galilean covariant. The relevance of these results for real passive advection and comparison with the Gaussian models and experiments are briefly discussed.

Search for tau-neutrino interactions in the BEBC beam dump experiment

NASA Astrophysics Data System (ADS)

Talebzadeh, M.; Guy, J.; Venus, W.; Aderholz, M.; Barnham, K. W. J.; Bostock, P.; Clayton, E. F.; Cooper-Sarkar, A. M.; Faccini-Turluer, M. L.; Grässler, H.; Hultquist, K.; Hulth, P. O.; Kreutzmann, H.; Krstic, J.; Miller, D. B.; Mobayyen, M. M.; Myatt, G.; Nellen, B.; Parker, M. A.; Schmitz, N.; Sewell, S.; Simopoulou, E.; Vayaki, A.; Vignaud, D.; Wachsmuth, H.; Wittek, W.; Wünsch, B.; BEBC WA66 Collaboration

A novel and efficient kinematic method is used to estimate the number of ντ charged current interactions with Eν > 20 GeV in the BEBC beam dump experiment. The result, -14±12 ντ events, is consistent with zero. The ratio of D s to D meson production in 400 GeV proton interactions in copper is estimated to be below 0.65 at 90% c.l. The oscillation probability P( νe→ ντ) averaged over the electron-(anti)neutrino spectrum is found to be below 18%. The hypothesis that νe and ντ are identical is excluded by about 6 standard deviations. A remarkable event is described: it contains a muon, a high pT photon and a high pT hadron.

A Qualitative and Quantitative Assessment of Readiness for Organizational Change Literature

DTIC Science & Technology

2008-06-01

The behavioral sciences and management: An evaluation of relevant journals. Journal of Management, 16(3), 539. Fishbein , M ., & Ajzen , I . (1975...discovery to change beliefs, attitudes, intentions, and behavior ( Fishbein & Ajzen , 1975). In the context of strategic change, participation produces high...Science Quarterly, 21, 700-714. 44 *Eby, L. T., Adams, D. M ., Russell, J. E. A., & Gaby, S. H. ( 2000 ). Perceptions of organizational readiness

Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings.

PubMed

Barja-Fernandez, Silvia; Moreno-Navarrete, José María; Folgueira, Cintia; Xifra, Gemma; Sabater, Mònica; Castelao, Cecilia; FernØ, Johan; Leis, Rosaura; Diéguez, Carlos; Casanueva, Felipe F; Ricart, Wifredo; Seoane, Luisa M; Fernandez-Real, José Manuel; Nogueiras, Rubén

2018-05-01

Angiopoietin-like protein 4 (ANGPTL-4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL-4 levels in obesity, T2D, and after changes in body weight. Circulating ANGPTL-4 levels were measured in two different cohorts. First, in a cross-sectional study, we evaluated ANGPTL-4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow-up 2 years later. ANGPTL-4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL-4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA-IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow-up showed increased ANGPTL-4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL-4 levels were reduced in participants losing weight. Our data support a relevant role of ANGPTL-4 in human obesity and its involvement in long-term body weight changes. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Suppression of Overhauser Effect in the Exciton-Nuclear Spin System of GaAs Quantum Dot

DTIC Science & Technology

2001-06-01

the exciton-nuclear spin system of GaAs quantum dot V L. Korenevt, I. A. Merkulovt, D. Gammonj, Al. L. Efrosj, T. A. Kennedyl, M. Rosenj, D. S ...Katzerj and S . W. Brown§ t loffe Physico-Technical Institute, St Petersburg, Russia I Naval Research Laboratory, Washington DC 20375, USA § NIST...2.5 s -1 for N - 105 nuclei in the quantum dot [51 and rb - 0.1 ns [9]. The estimation is in agreement with experiment (Texp ; 3 s ). Coupling of

Lymphocyte roles in metabolic dysfunction: of men and mice

PubMed Central

Ip, Blanche C.; Hogan, Andrew E.; Nikolajczyk, Barbara S.

2015-01-01

Type 2 diabetes (T2D) is a metabolic disease associated with obesity-related insulin resistance (IR) and chronic inflammation. Animal studies indicate IR can be caused and/or exacerbated by systemic/tissue-specific alterations in lymphocyte differentiation and function. Human studies also indicate obesity and/or inflammation promotes IR. Nevertheless, clinical trials with anti-inflammatory therapies have yielded modest impacts on established T2D. Unlike mouse models where obesity is predominantly associated with IR, 20–25% of obese people are metabolically healthy with high insulin sensitivity. The uncoupling of obesity from IR in humans but not in animal models advocates for a more comprehensive understanding of mediators/mechanisms in human obesity-promoted IR, and better integration of knowledge from human studies into animal experiments to efficiently pursue T2D prevention and treatment. PMID:25573740

Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans.

PubMed

White, Tara L; Monnig, Mollie A; Walsh, Edward G; Nitenson, Adam Z; Harris, Ashley D; Cohen, Ronald A; Porges, Eric C; Woods, Adam J; Lamb, Damon G; Boyd, Chelsea A; Fekir, Sinda

2018-06-01

Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy ( 1 H MRS). Single clinically relevant doses of d-amphetamine (AMP, 20 mg oral), methamphetamine (MA, 20 mg oral; Desoxyn®), or placebo were administered to healthy participants (n = 26) on three separate test days in a placebo-controlled, double-blinded, within-subjects crossover design. Each participant experienced all three conditions and thus served as his/her own control. 1 H MRS was conducted in the dorsal anterior cingulate cortex (dACC), an integrative neocortical hub, during the peak period of drug responses (140-150 m post ingestion). D-amphetamine increased the level of Glu (p = .0001), Glx (p = .003), and tCr (p = .0067) in the dACC. Methamphetamine increased Glu in females, producing a significant crossover interaction pattern with gender (p = .02). Drug effects on Glu, tCr, and Glx were positively correlated with subjective drug responses, predicting both the duration of AMP liking (Glu: r = +.49, p = .02; tCr: r = +.41, p = .047) and the magnitude of peak drug high to MA (Glu: r = +.52, p = .016; Glx: r = +.42, p = .049). Neither drug affected the levels of tNAA, Cho, or Ins after correction for multiple comparisons. We conclude that d-amphetamine increased the concentration of glutamate, Glx, and tCr in the dACC in male and female volunteers 2 1 / 2 hours after drug consumption. There was evidence that methamphetamine differentially affects dACC Glu levels in women and men. These findings provide the first experimental evidence that specific psychostimulants increase the level of glutamatergic compounds in the human brain, and that glutamatergic changes predict the extent and magnitude of subjective responses to psychostimulants.

Association of circulating total bilirubin with the metabolic syndrome and type 2 diabetes: A systematic review and meta-analysis of observational evidence.

PubMed

Nano, J; Muka, T; Cepeda, M; Voortman, T; Dhana, K; Brahimaj, A; Dehghan, A; Franco, O H

2016-12-01

Emerging evidence suggests that bilirubin levels might be associated with the metabolic syndrome (MetS) and type 2 diabetes (T2D), although the nature of the association remains unclear. This systematic review and meta-analysis investigated the relationship between total plasma bilirubin and the risk of MetS and T2D. Relevant studies were identified using five databases (Embase, Medline [Ovid], Web of Science, PubMed, Cochrane Central and Google Scholar), with the last search done on 21 October 2015. Study references were checked and authors contacted to identify additional studies. Randomized controlled trials, and cohort, case-control and cross-sectional studies of adults examining the association between blood bilirubin levels and MetS and T2D were included, irrespective of language and date of publication. Abstract and full-text selection was done by two independent reviewers, with a third reviewer available in case of disagreement. Data were extracted by two independent reviewers using a predesigned data collection form. MetS and T2D. Summary estimates were obtained by random-effects meta-analysis. Of the 2313 searched references, 16 observational studies (11 cross-sectional, two prospective, one that was both cross-sectional and prospective, two retrospective and one national survey) met our inclusion criteria. Overall, data were available for 175,911 non-overlapping participants, including 7414 MetS cases and 9406 T2D cases. In the meta-analysis of seven cross-sectional studies, the pooled odds ratio (95% confidence interval) for MetS in a comparison of extreme tertiles of serum bilirubin levels was 0.70 (95% CI: 0.62, 0.78), whereas no significant association was found for the pooled estimated relative risk between two prospective studies (0.57, 95% CI: 0.11, 2.94). The corresponding estimate was 0.77 (95% CI: 0.67, 0.87) for T2D from four cross-sectional studies. The available evidence, mainly from cross-sectional studies, supports an inverse association of bilirubin levels with adverse metabolic outcomes. Large-scale prospective studies are now needed to establish whether bilirubin levels may be useful in the prevention of MetS and T2D. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Band-Aids Don't Fix Bullet Holes. A Response to "We Were There Too: Learning from Black Male Teachers in Mississippi about Successful Teaching of Black Students"

ERIC Educational Resources Information Center

Jackson, Melinda; Green, Dari; Martin, Lori Latrice; Fasching-Varner, Kenneth J.

2016-01-01

Hayes, Juarez, and Escoffery-Runnels (2014) analyzed the educational philosophies and pedagogical practices of two educators to understand how personal and professional experiences individually and collectively influenced their approach to teaching. Using oral histories, they presented an argument of why culturally relevant and social…

76 FR 19434 - Roni Dreszer, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... evidence under the [experience] * * * factor[] support[s]'' the revocation of his registration, is consistent with Agency precedent. Id. With respect to factor five, ``[s]uch other conduct which may threaten... factor requires some showing that the relevant conduct actually constituted a threat to public safety...

Acclimation of Foliar Respiration and Photosynthesis in Response to Experimental Warming in a Temperate Steppe in Northern China

PubMed Central

Chi, Yonggang; Xu, Ming; Shen, Ruichang; Yang, Qingpeng; Huang, Bingru; Wan, Shiqiang

2013-01-01

Background Thermal acclimation of foliar respiration and photosynthesis is critical for projection of changes in carbon exchange of terrestrial ecosystems under global warming. Methodology/Principal Findings A field manipulative experiment was conducted to elevate foliar temperature (T leaf) by 2.07°C in a temperate steppe in northern China. R d/T leaf curves (responses of dark respiration to T leaf), A n/T leaf curves (responses of light-saturated net CO2 assimilation rates to T leaf), responses of biochemical limitations and diffusion limitations in gross CO2 assimilation rates (A g) to T leaf, and foliar nitrogen (N) concentration in Stipa krylovii Roshev. were measured in 2010 (a dry year) and 2011 (a wet year). Significant thermal acclimation of R d to 6-year experimental warming was found. However, A n had a limited ability to acclimate to a warmer climate regime. Thermal acclimation of R d was associated with not only the direct effects of warming, but also the changes in foliar N concentration induced by warming. Conclusions/Significance Warming decreased the temperature sensitivity (Q 10) of the response of R d/A g ratio to T leaf. Our findings may have important implications for improving ecosystem models in simulating carbon cycles and advancing understanding on the interactions between climate change and ecosystem functions. PMID:23457574

Analytic, empirical and delta method temperature derivatives of D-D and D-T fusion reactivity formulations, as a means of verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langenbrunner, James R.; Booker, Jane M.

We examine the derivatives with respect to temperature, for various deuterium-tritium (DT) and deuterium-deuterium (D-D) fusion-reactivity formulations. Langenbrunner and Makaruk [1] had studied this as a means of understanding the time and temperature domain of reaction history measured in dynamic fusion experiments. Presently, we consider the temperature derivative dependence of fusion reactivity as a means of exercising and verifying the consistency of the various reactivity formulations.

“Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- T c superconductors

DOE PAGES

Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

2015-03-07

Recenmore » tly it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the d -wave nodal lines (nodal gap) contrasts the common understanding of the d -wave pairing symmetry, which challenges the present theories for the high- T c superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high- T c superconductors.« less

Nuclear magnetic resonance studies on yeast tRNAPhe. II. Assignment of the iminoproton resonances of the anticodon and T stem by means of nuclear Overhauser effect experiments at 500 MHz.

PubMed Central

Heerschap, A; Haasnoot, C A; Hilbers, C W

1983-01-01

Resonances of the water exchangeable iminoprotons of the T and anticodon stem of yeast tRNAPhe were assigned by means of Nuclear Overhauser Effects (NOE's). Together with our previous assignments of iminoproton resonances from the acceptor and D stem (A. Heerschap, C.A.G. Haasnoot and C.W. Hilbers (1982) Nucleic Acids Res. 10, 6981-7000) the present results constitute a complete assignment of all resonances of iminoprotons involved in the secondary structure of yeast tRNAPhe with a reliability and spectral resolution not reached heretofore. Separate identification of the methylprotons in m5C40 and m5C49 was also possible due to specific NOE patterns in the lowfield part of the spectrum. Our experiments indicate that in solution the psi 39 residue in the anticodon stem is orientated in a syn conformation in contrast to the normally observed anti orientation of the uracil base in AU basepairs. Evidence is presented that in solution the acceptor stem is stacked upon the T stem. Furthermore, it turns out that in a similar way the anticodon stem forms a continuous stack with the D stem, but here the m2(2)G26 residue is located between the latter two stems (as is found in the X-ray crystal structure). The stacking of these stems is not strictly dependent on the presence of magnesium ions. NOE experiments show that these structural features are preserved when proceeding from a buffer with magnesium ions to a buffer without magnesium ions although differences in chemical shifts and NOE intensities indicate changes in the conformation of the tRNA. PMID:6346268

Calculation of Coherent Radiation from Ultra-short Electron Beams Using a Lienard-Wiechert Based Simulation Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flacco, A.; Fairchild, M.; Reiche, S.

2004-12-07

The coherent radiation emitted by electrons in high brightness beam-based experiments is important from the viewpoints of both radiation source development, and the understanding and diagnosing the basic physical processes important in beam manipulations at high intensity. While much theoretical work has been developed to aid in calculating aspects of this class of radiation, these methods do not often produce accurate information concerning the experimentally relevant aspects of the radiation. At UCLA, we are particularly interested in coherent synchrotron radiation and the related phenomena of coherent edge radiation, in the context of a fs-beam chicane compression experiment at the BNLmore » ATF. To analyze this and related problems, we have developed a program that acts as an extension to the Lienard-Wiechert-based 3D simulation code TREDI, termed FieldEye. This program allows the evaluation of electromagnetic fields in the time and frequency domain in an arbitrary 2D detector planar area. We discuss here the implementation of the FieldEye code, and give examples of results relevant to the case of the ATF chicane compressor experiment.« less

Identification of novel indole based heterocycles as selective estrogen receptor modulator.

PubMed

Singla, Ramit; Prakash, Kunal; Bihari Gupta, Kunj; Upadhyay, Shishir; Dhiman, Monisha; Jaitak, Vikas

2018-04-24

In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II after sequential combinatorial library generation, docking, absorption, distribution, metabolism and excretion (ADME) filtering, anti-proliferative activity, cytotoxicity, and ER-α competitor assay kit by utilizing estrogen receptor-α (ER-α) dominant T47D BC cells line and PBMCs (Peripheral Blood Mononuclear Cells). Cell imaging experiment suggested that both the compounds successfully cross cellular biomembrane and accumulate in nuclear, cytoplasmic and plasma membrane region. Semiquantitative RT-PCR and Western blotting experiments further supported that both compounds reduced the expression of mRNA and receptor protein of ER-α, thereby preventing downstream transactivation and signaling pathway in T47D cells line. Current findings imply that 5c and 6d represent novel ER-α antagonists and may be used in the development of chemotherapy for the management of BC. Copyright © 2018 Elsevier Inc. All rights reserved.

The entero-insular axis: implications for human metabolism.

PubMed

Ranganath, Lakshminarayan R

2008-01-01

Incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are intestinal hormones that are released in response to ingestion of nutrients, especially carbohydrate. They have a number of important biological effects, which include release of insulin, inhibition of glucagon and somatostatin, maintenance of beta-cell mass, delay of gastric emptying, and inhibition of feeding. These properties allow them to be potentially suitable agents for the treatment of type 2 diabetes (T2D). Incretin receptors are also present in other parts of the body including the brain, where their effects are beginning to be understood and their relevance to disorders of nutrition and ageing are being explored. There is currently a pandemic of obesity and diabetes, and existing treatments are largely inadequate in regard to efficacy as well as their ability to tackle important factors in the pathogenesis of T2D. There is increasing evidence that current treatments do not address the issue of progressive beta-cell failure in T2D. As obesity is the engine that is driving the epidemic of diabetes, it is disappointing that most treatments that succeed in lowering plasma glucose are also associated with weight gain. It is now well established that intensively treated T2D has a better outcome than standard treatment. Consequently, achieving better control of diabetes with lower HbA1c is the goal of optimal treatment. Despite the use of usual therapeutic agents in T2D, often in high doses and as combinations, such as metformin, sulphonylurea, alpha-glycosidase inhibitors, thiazolidinediones and a number of animal and human insulin preparations, optimal control of glycaemia is not achieved. The use of incretins as therapeutic agents offers a new approach to the treatment of T2D. Incretin metabolism is abnormal in T2D, evidenced by a decreased incretin effect, reduction in nutrient-mediated secretion of GIP and GLP-1 in T2D, and resistance to GIP. GLP-1, on the other hand, when administered intravenously in T2D is able to increase insulin secretion and improve glucose homeostasis. As GLP-1 has a very short half-life, due to rapid degradation by the enzyme dipeptidyl peptidase IV (DPPIV), analogues of GIP and GLP-1 that are resistant to the action of DPPIV have been developed and clinical trials have shown their effectiveness. Another novel agent, naturally resistant to DPPIV that is given by subcutaneous injection is a synthetic peptide called exenatide, has recently been approved for treatment of T2D in the USA. Efforts are underway to develop agents that can be given orally and include a DPPIV inhibitor that has been licensed for the treatment of T2D in the USA, and several other agents are undergoing clinical trials. Strategies to augment the biological actions of GIP and/or GLP-1 in T2D are expected to minimise weight gain, reduce hypoglycaemic episodes and prevent progressive beta-cell failure by increasing beta-cell mass. The optimal agent(s) that may mimic and replace the endogenous incretin effect is not fully known and awaits the outcome of clinical trials that are still ongoing. The potential therapeutic role in non-diabetic states, including obesity and neurodegenerative disease, is intriguing and depends upon results from ongoing research.

Energy and Charge Localization in Irradiated DNA

DTIC Science & Technology

1994-01-01

distances. Numerous experiments support this viewpoint. As an example we note that exciplex formation in DNA is a rapid process /31/ estimated to be the...B-DNA) and tT is the trapping time. Assuming an exciplex formation time of 10`2 sec gives a transfer distance d, of 1.5 nm or approximately 4 to 5

Syntheses, structures, and 1H, 13C{ 1H} and 119Sn{ 1H} NMR chemical shifts of a family of trimethyltin alkoxide, amide, halide and cyclopentadienyl compounds

DOE PAGES

Lichtscheidl, Alejandro G.; Janicke, Michael T.; Scott, Brian L.; ...

2015-08-21

The synthesis and full characterization, including Nuclear Magnetic Resonance (NMR) data ( 1H, 13C{ 1H} and 119Sn{ 1H}), for a series of Me 3SnX (X = O-2,6-tBu 2C 6H 3 (1), (Me 3Sn)N(2,6- iPr 2C 6H 3) (3), NH-2,4,6- tBu 3C 6H 2 (4), N(SiMe 3) 2 (5), NEt 2, C 5Me 5 (6), Cl, Br, I, and SnMe 3) compounds in benzene-d 6, toluene-d 8, dichloromethane-d 2, chloroform-d 1, acetonitrile-d 3, and tetrahydrofuran-d 8 are reported. The X-ray crystal structures of Me 3Sn(O-2,6- tBu 2C 6H 3) (1), Me 3Sn(O-2,6- iPr 2C 6H 3) (2), and (Me 3Sn)(NH-2,4,6- tBumore » 3C 6H 2) (4) are also presented. As a result, these compiled data complement existing literature data and ease the characterization of these compounds by routine NMR experiments.« less

Measurement of D 0 Azimuthal Anisotropy at Midrapidity in Au + Au Collisions at s N N = 200 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.

In this paper, we report the first measurement of the elliptic anisotropy (v2) of the charm meson D 0 at midrapidity (|y| < 1) in Au + Au collisions atmore » $$\\sqrt{s}$$$_ {NN}$$ = 200 GeV. The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D 0 v 2 in 0%–80% centrality Au + Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (p T) of less than 4 GeV/c . The D 0 v 2 as a function of transverse kinetic energy (m T - m 0 , where m T = $$\\sqrt{p}$$$2\\atop{T}$$ + m$$2\\atop{0}$$) is consistent with that of light mesons in 10%–40% centrality Au + Au collisions. These results suggest that charm quarks have achieved local thermal equilibrium with the medium created in such collisions. In conclusion, several theoretical models, with the temperature-dependent, dimensionless charm spatial diffusion coefficient (2πTD s) in the range of ~2–12 , are able to simultaneously reproduce our D 0 v 2 result and our previously published results for the D 0 nuclear modification factor.« less

Measurement of D 0 Azimuthal Anisotropy at Midrapidity in Au + Au Collisions at s N N = 200 GeV

DOE PAGES

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; ...

2017-05-26

In this paper, we report the first measurement of the elliptic anisotropy (v2) of the charm meson D 0 at midrapidity (|y| < 1) in Au + Au collisions atmore » $$\\sqrt{s}$$$_ {NN}$$ = 200 GeV. The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D 0 v 2 in 0%–80% centrality Au + Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (p T) of less than 4 GeV/c . The D 0 v 2 as a function of transverse kinetic energy (m T - m 0 , where m T = $$\\sqrt{p}$$$2\\atop{T}$$ + m$$2\\atop{0}$$) is consistent with that of light mesons in 10%–40% centrality Au + Au collisions. These results suggest that charm quarks have achieved local thermal equilibrium with the medium created in such collisions. In conclusion, several theoretical models, with the temperature-dependent, dimensionless charm spatial diffusion coefficient (2πTD s) in the range of ~2–12 , are able to simultaneously reproduce our D 0 v 2 result and our previously published results for the D 0 nuclear modification factor.« less

Effets de l'interaction avec l'oxygène sur le comportement de couches semi-conductrices de ZnO, SnO{2} et CdSe

NASA Astrophysics Data System (ADS)

Ain-Souya, A.; Ghers, M.; Haddad, A.; Tebib, W.; Rehamnia, R.; Messsalhi, A.; Bounouala, M.; Djouama, M. C.

2005-05-01

Les propriétés superficielles des matériaux solides diffèrent de celles du volume. A la surface, des défauts de différentes natures peuvent être présents. Ils permettent à la surface d'être interactive avec le milieu ambiant. Les multiples interactions entre les états de surface et des éléments du milieu extérieur peuvent modifier les propriétés superficielles. Ce travail étudie la régénération de couches semi-conductrices après adsorption isotherme d'oxygène à différentes températures effectuées entre 20 ° C et 300 ° C. Les matériaux qui ont servi à l'étude sont des couches de ZnO, SnO{2} et CdSe. Celles de CdSe ont été obtenues par co-évaporation, sous vide, de cadmium et de sélénium. Les échantillons de ZnO et SnO{2} ont été élaborés par oxydation, à des températures respectives de 450 ° C et 200 ° , de Zn et Sn déposés par électrolyse et par évaporation sous vide. Les matériaux évaporés ont été déposés sur des plaquettes en verre, les autres ont été électrodéposés sur des substrats métalliques. Les variations des propriétés électriques des couches ont été suivies par mesure de leur résistance électrique superficielle R. Les courbes LogR = f (103 /T (K)), relevées sous vide à différentes températures, sont caractéristiques d'un comportement de semi-conducteur. Des essais d'adsorption d'O{2} à différentes températures montrent des variations considérables de R. En effet, la chimisorption forte d'un gaz par une surface semi-conductrice est telle que l'échange électronique entre adsorbant et adsorbat provoque la formation d'une zone de charge d'espace modifiant la conduction superficielle. Les résultats mettent en évidence des domaines de température de plus haute sensibilité à l'oxygène. Pour le CdSe, certaines désorptions isothermes ont été suffisantes pour une régénération totale des échantillons. Les couches de ZnO ont souvent nécessité des désorptions programmées en température (D.P.T.), pour leur restauration à l'état initial, après ionosorption d'O{2}. L'exploitation des courbes de variation de R en cours de D.P.T. permet de déterminer les énergies mises en jeu. Les résultats prouvent que les réactions des états de surface avec l'oxygène sont multiénergétiques. La réactivité de ces couches vis à vis de cet élément dépend fortement de leurs conditions d'élaboration. Ainsi, ces échantillons pourraient servir à la détection de gaz réducteurs d'O{2} qui s'adsorberait par réduction de l'oxygène ionosorbé, et provoquerait un effet inverse sur la conduction, telle qu'une augmentation de la conductivité superficielle ou une diminution de la résistance d'un matériau semi-conducteur de type n. Ces variations sont importantes lorsque la concentration d'oxygène ionosorbé est grande, donc dans les domaines de température de plus haute sensibilité à l'oxygène. Ce mécanisme serait révélateur de la présence d'un gaz réducteur dans l'atmosphère et la surface d'un semi-conducteur pourrait servir d'élément sensible d'un détecteur de gaz.

Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples.

PubMed

Borsu, Laetitia; Intrieri, Julie; Thampi, Linta; Yu, Helena; Riely, Gregory; Nafa, Khedoudja; Chandramohan, Raghu; Ladanyi, Marc; Arcila, Maria E

2016-11-01

Although next-generation sequencing (NGS) is a robust technology for comprehensive assessment of EGFR-mutant lung adenocarcinomas with acquired resistance to tyrosine kinase inhibitors, it may not provide sufficiently rapid and sensitive detection of the EGFR T790M mutation, the most clinically relevant resistance biomarker. Here, we describe a digital PCR (dPCR) assay for rapid T790M detection on aliquots of NGS libraries prepared for comprehensive profiling, fully maximizing broad genomic analysis on limited samples. Tumor DNAs from patients with EGFR-mutant lung adenocarcinomas and acquired resistance to epidermal growth factor receptor inhibitors were prepared for Memorial Sloan-Kettering-Integrated Mutation Profiling of Actionable Cancer Targets sequencing, a hybrid capture-based assay interrogating 410 cancer-related genes. Precapture library aliquots were used for rapid EGFR T790M testing by dPCR, and results were compared with NGS and locked nucleic acid-PCR Sanger sequencing (reference high sensitivity method). Seventy resistance samples showed 99% concordance with the reference high sensitivity method in accuracy studies. Input as low as 2.5 ng provided a sensitivity of 1% and improved further with increasing DNA input. dPCR on libraries required less DNA and showed better performance than direct genomic DNA. dPCR on NGS libraries is a robust and rapid approach to EGFR T790M testing, allowing most economical utilization of limited material for comprehensive assessment. The same assay can also be performed directly on any limited DNA source and cell-free DNA. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Chemistry in the Dunes of Titan: Tribochemical Reactions of Complex Organics and Water Ice

NASA Astrophysics Data System (ADS)

Beauchamp, J. L.; Thomas, D. A.

2010-12-01

Titan’s N2-CH4 atmosphere provides the starting material for a wide array of organic compounds to be formed via photochemistry, and the presence of unsaturated hydrocarbon, amine, and polycyclic aromatic species has been supported by data from the Cassini-Huygens mission [1,2]. Production of tholins by UV irradiation of a simulated N2-CH4 environment has yielded products that match the observed optical properties of Titan haze, suggesting that these compounds provide suitable analogs to Titan aerosol compounds [3, 4, 5]. Organics produced in Titan’s atmosphere eventually settle to the surface and very likely contribute to the particulate matter comprising the expansive longitudinal dune features observed at mid-latitudes [6]. Once on the surface, conditions that lead to incorporation of oxygen via contact with water ice or liquid water in Titan’s low temperature environment are of particular interest and have important implications for astrobiology [7; 8]. In this work, we postulate that the mechanical energy from wind-driven grains in the dunes of Titan can ultimately drive chemical processes and lead to the incorporation of oxygen into organic compounds via tribochemical reactions [9] and describe experiments designed to test this hypothesis. While the exact composition of the dunes of Titan is unknown, it is likely that they mainly comprise organic and water ice particles approximately 0.2 mm in diameter, the ideal size for saltation by the winds of Titan [6]. During the saltation process, organic particles undergo charging due to friction between particles, leading in turn to formation of ions and free radicals in localized electrical discharges at particle interfaces [10]. These reactive intermediates can initiate processes such as free radical and ionic polymerization that further transform organics. Of particular interest is the incorporation of oxygen into organic molecules, providing a pathway to the synthesis of biologically relevant compounds. Experiments modeling such systems are being conducted with laboratory-produced tholins and model unsaturated hydrocarbons, nitriles, imines, and aromatic compounds, and the results and implications of these studies will be presented. 1. Coates, A. J., A. Wellbrock, G. R. Lewis, G. H. Jones, D. T. Young, F. J. Crary, and J. H. Waite Jr (2009), Planet. Space Sci., 57(14-15), 1866-1871. 2. Crary, F. J., B. A. Magee, K. Mandt, J. H. Waite Jr, J. Westlake, and D. T. Young (2009), Planet. Space Sci., 57(14-15), 1847-1856. 3. Khare, B. N., C. Sagan, E. T. Arakawa, F. Suits, T. A. Callcott, and M. W. Williams (1984), Icarus, 60(1), 127-137. 4. Ramirez, S. I., P. Coll, A. da Silva, R. Navarro-González, J. Lafait, and F. Raulin (2002), Icarus, 156(2), 515-529. 5. Imanaka, H., and M. A. Smith (2010), Proc. Natl. Acad. Sci. U.S.A., 107(28), 12423-12428. 6. Lorenz, R. D., et al. (2006), Science, 312(5774), 724-727. 7. O'Brien, D. P., R. D. Lorenz, and J. I. Lunine (2005), Icarus, 173(1), 243-253. 8. Neish, C. D., A. Somogyi, and M. A. Smith (2010), Astrobiology, 10(3), 337-347. 9. Beyer, M. K., and H. Clausen-Schaumann (2005), Chem. Rev., 105(8), 2921-2948. 10. Kajdas, C., and K. Hiratsuka (2009), Proc. Inst. Mech. Eng., Part J, 223(6), 827-848.

Prostate segmentation: an efficient convex optimization approach with axial symmetry using 3-D TRUS and MR images.

PubMed

Qiu, Wu; Yuan, Jing; Ukwatta, Eranga; Sun, Yue; Rajchl, Martin; Fenster, Aaron

2014-04-01

We propose a novel global optimization-based approach to segmentation of 3-D prostate transrectal ultrasound (TRUS) and T2 weighted magnetic resonance (MR) images, enforcing inherent axial symmetry of prostate shapes to simultaneously adjust a series of 2-D slice-wise segmentations in a "global" 3-D sense. We show that the introduced challenging combinatorial optimization problem can be solved globally and exactly by means of convex relaxation. In this regard, we propose a novel coherent continuous max-flow model (CCMFM), which derives a new and efficient duality-based algorithm, leading to a GPU-based implementation to achieve high computational speeds. Experiments with 25 3-D TRUS images and 30 3-D T2w MR images from our dataset, and 50 3-D T2w MR images from a public dataset, demonstrate that the proposed approach can segment a 3-D prostate TRUS/MR image within 5-6 s including 4-5 s for initialization, yielding a mean Dice similarity coefficient of 93.2%±2.0% for 3-D TRUS images and 88.5%±3.5% for 3-D MR images. The proposed method also yields relatively low intra- and inter-observer variability introduced by user manual initialization, suggesting a high reproducibility, independent of observers.

Analogous Three-Dimensional Constructive Interference in Steady State Sequences Enhance the Utility of Three-Dimensional Time of Flight Magnetic Resonance Angiography in Delineating Lenticulostriate Arteries in Insular Gliomas: Evidence from a Prospective Clinicoradiologic Analysis of 48 Patients.

PubMed

Rao, Arun S; Thakar, Sumit; Sai Kiran, Narayanam Anantha; Aryan, Saritha; Mohan, Dilip; Hegde, Alangar S

2018-01-01

Three-dimensional (3D) time of flight (TOF) imaging is the current gold standard for noninvasive, preoperative localization of lenticulostriate arteries (LSAs) in insular gliomas; however, the utility of this modality depends on tumor intensity. Over a 3-year period, 48 consecutive patients with insular gliomas were prospectively evaluated. Location of LSAs and their relationship with the tumor were determined using a combination of contrast-enhanced coronal 3D TOF magnetic resonance angiography and coronal 3D constructive interference in steady state (CISS) sequences. These findings were analyzed with respect to extent of tumor resection and early postoperative motor outcome. Tumor was clearly visualized in 29 (60.4%) patients with T1-hypointense tumors using 3D TOF and in all patients using CISS sequences. Using combined 3D TOF and CISS, LSA-tumor interface was well seen in 47 patients, including all patients with T1-heterointense or T1-isointense tumors. Extent of resection was higher in the LSA-pushed group compared with the LSA-encased group. In the LSA-encased group, 6 (12.5%) patients developed postoperative hemiparesis; 2 (4.2%) cases were attributed to LSA injury. Contrast-enhanced 3D TOF can delineate LSAs in almost all insular gliomas but is limited in identifying the LSA-tumor interface. This limitation can be overcome by addition of analogous CISS sequences that delineate the LSA-tumor interface regardless of tumor intensity. Combined 3D TOF and 3D CISS is a useful tool for surgical planning and safer resections of insular tumors and may have added surgical relevance when included as an intraoperative adjunct. Copyright © 2017 Elsevier Inc. All rights reserved.

Pressure-induced transformations in glassy water: A computer simulation study using the TIP4P/2005 model.

PubMed

Wong, Jessina; Jahn, David A; Giovambattista, Nicolas

2015-08-21

We study the pressure-induced transformations between low-density amorphous (LDA) and high-density amorphous (HDA) ice by performing out-of-equilibrium molecular dynamics (MD) simulations. We employ the TIP4P/2005 water model and show that this model reproduces qualitatively the LDA-HDA transformations observed experimentally. Specifically, the TIP4P/2005 model reproduces remarkably well the (i) structure (OO, OH, and HH radial distribution functions) and (ii) densities of LDA and HDA at P = 0.1 MPa and T = 80 K, as well as (iii) the qualitative behavior of ρ(P) during compression-induced LDA-to-HDA and decompression-induced HDA-to-LDA transformations. At the rates explored, the HDA-to-LDA transformation is less pronounced than in experiments. By studying the LDA-HDA transformations for a broad range of compression/decompression temperatures, we construct a "P-T phase diagram" for glassy water that is consistent with experiments and remarkably similar to that reported previously for ST2 water. This phase diagram is not inconsistent with the possibility of TIP4P/2005 water exhibiting a liquid-liquid phase transition at low temperatures. A comparison with previous MD simulation studies of SPC/E and ST2 water as well as experiments indicates that, overall, the TIP4P/2005 model performs better than the SPC/E and ST2 models. The effects of cooling and compression rates as well as aging on our MD simulations results are also discussed. The MD results are qualitatively robust under variations of cooling/compression rates (accessible in simulations) and are not affected by aging the hyperquenched glass for at least 1 μs. A byproduct of this work is the calculation of TIP4P/2005 water's diffusion coefficient D(T) at P = 0.1 MPa. It is found that, for T ≥ 210 K, D(T) ≈ (T - T(MCT))(-γ) as predicted by mode coupling theory and in agreement with experiments. For TIP4P/2005 water, T(MCT) = 209 K and γ = 2.14, very close to the corresponding experimental values T(MCT) = 221 K and γ = 2.2.

Correlation functions in the D1-D5 orbifold CFT

NASA Astrophysics Data System (ADS)

i Tormo, Joan Garcia; Taylor, Marika

2018-06-01

The D1-D5 system has an orbifold point in its moduli space, at which it may be described by an N = (4,4) supersymmetric sigma model with target space M N /S( N) where M is T^4 or K3. In this paper we consider correlation functions involving chiral operators constructed from twist fields: we find explicit expressions for processes involving a twist n operator joining n twist operators of arbitrary twist. These expressions are universal, in that they are independent of the choice of M , and the final results can be expressed in a compact form. We explain how these results are relevant to the black hole microstate programme: one point functions of chiral operators can be used to reconstruct AdS3 near horizon regions of D1-D5 microstates and to match microstates constructed in supergravity with the CFT.

Non-solenoidal Startup via Local Helicity Injection on Pegasus: Progress and Plans

NASA Astrophysics Data System (ADS)

Reusch, J. A.; Barr, J. L.; Bodner, G. M.; Bongard, M. W.; Burke, M. G.; Fonck, R. J.; Hinson, E. T.; Lewicki, B. T.; Perry, J. M.; Schlossberg, D. J.

2015-11-01

Non-solenoidal plasma startup via local helicity injection (LHI) at the Pegasus toroidal experiment now provides routine operation at Ip ~ 0.17MA with Iinj ~ 5kA and Vinj ~ 1kV from four active arc injectors. Experiments in the past year have advanced the understanding of the governing physics of LHI and its supporting technology. Injector impedance scales as Vinj3/ 2 and is governed by two effects: a quasineutrality constraint on electron beam propagation, related to the tokamak edge density, and double-layer sheath expansion, related to narc. Injector design improvements permit operation at Vinj >= 1 kV without deleterious PMI or impurity generation. Discharges with varied shape, Ip(t), and helicity input test a predictive 0D power-balance model for LHI startup. Anomalous, reconnection-driven Ti >800 eV and strong MHD activity localized near the injectors are observed during LHI. Preliminary core Thomson scattering measurements indicate surprisingly high Te >300 eV, which if verified may indicate the dominance of high-energy electron fueling from the injector current streams. A new divertor injector system has been designed to substantially increase the available helicity input rate and support critical studies of confinement during LHI and reconnection activity at high Ip. A proposed upgrade to the Pegasus experiment will extend these studies to NSTX-U relevant parameters. Support: US DOE grants DE-FG02-96ER54375; and DE-SC0006928.

HNF1α defect influences post-prandial lipid regulation

PubMed Central

St-Jean, Matthieu; Boudreau, François; Carpentier, André C.

2017-01-01

Purpose Hepatocyte nuclear factor 1 alpha (HNF1α) defects cause Mature Onset Diabetes of the Young type 3 (MODY3), characterized by defects in beta-cell insulin secretion. However, HNF1α is involved in many other metabolic pathways with relevance for monogenic or polygenic type 2 diabetes. We aimed to investigate gut hormones, lipids, and insulin regulation in response to a meal test in HNF1α defect carriers (MODY3) compared to non-diabetic subjects (controls) and type 2 diabetes (T2D). Methods We administered a standardized liquid meal to each participant. Over 6 hours, we measured post-meal responses of insulin regulation (blood glucose, c-peptide, insulin), gut hormones (ghrelin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1) and lipids (non-esterified fatty acids [NEFA] and triglycerides). Results We found that MODY3 participants had lower insulin secretion indices than controls and T2D participants, showing the expected β-cell defect. MODY3 had similar glycated hemoglobin levels (HbA1c median [IQR]: 6.5 [5.6–7.6]%) compared to T2D (median: 6.6 [6.2–6.9]%; P<0.05). MODY3 had greater insulin sensitivity (Matsuda index: 71.9 [29.6; 125.5]) than T2D (3.2 [4.0; 6.0]; P<0.05). MODY3 experienced a larger decrease in the ratio of NEFA to insulin (NEFA 30–0 / insulin 30–0: -39 [-78; -30] x104) in the early post-prandial period (0–30 minutes) compared to controls and to T2D (-2.0 [-0.6; -6.4] x104; P<0.05). MODY3 had lower fasting (0.66 [0.46; 1.2] mM) and post-meal triglycerides levels compared to T2D (fasting: 2.3 [1.7; 2.7] mM; P<0.05). We did not detect significant post-meal differences in ghrelin and incretins between MODY3 and other groups. Conclusion In response to a standard meal test, MODY3 showed greater early post-prandial NEFA diminution in response to relatively low early insulin secretion, and they maintained very low post-prandial triglycerides levels. PMID:28493909

How do quarks and gluons lose energy in the QGP?

DOE PAGES

Tannenbaum, M. J.

2015-03-10

RHIC introduced the method of hard scattering of partons as an in-situ probe of the the medium produced in A+A collisions. A suppression, R AA ≈ 0.2 relative to binary-scaling, was discovered for π⁰ production in the range 5 < ρ T < 20 GeV/c in central Au+Au collisions at √s NN = 200 GeV, and surprisingly also for single-electrons from the decay of heavy quarks. Both these results have been confirmed in Pb+Pb collisions at the LHC at √s NN = 2.76 TeV. Interestingly, in this ρ T range the LHC results for pions nearly overlap the RHIC results.more » Thus, due to the flatter spectrum, the energy loss in the medium at LHC in this ρ T range must be ~ 40% larger than at RHIC. Unique at the LHC are the beautiful measurements of the fractional transverse momentum imbalance 1 – (ρ-carot T2/ρ-carot T1) of di-jets in Pb+Pb collisions. At the Utrecht meeting in 2011, I corrected for the fractional imbalance of di-jets with the same cuts in p-p collisions and showed that the relative fractional jet imbalance in Pb+Pb/p-p is ≈ 15% for jets with 120 < ρ-carot T1 < 360 GeV/c. CMS later confirmed this much smaller imbalance compared to the same quantity derived from two-particle correlations of di-jet fragments at RHIC corresponding to ρ-carot T jet ≈ 10 – 20 GeV/c, which appear to show a much larger fractional jet imbalance ≈ 45% in this lower ρ-carot T range. The variation of apparent energy loss in the medium as a function of both ρ T and √s NN is striking and presents a challenge to both theory and experiment for improved understanding. There are many other such unresolved issues, for instance, the absence of evidence for a q-carot effect, due to momentum transferred to the medium by outgoing partons, which would widen the away-side di-jet and di-hadron correlations in a similar fashion as the k T-effect. Another issue well known from experiments at the CERN ISR, SpS and SpS collider is that parton-parton hard-collisions make negligible contribution to multiplicity or transverse energy production in p-p collisions–soft particles, with ρ T < 2 GeV/c, predominate. Thus an apparent hard scattering component for A+A multiplicity distributions based on a popular formula, dN AA ch/dη = [(1 - x) (N part)dN pp ch/dη2 + x (N colldN pp ch/dη], seems to be an unphysical way to understand the deviation from N part scaling. Based on recent p-p and d+A measurements, a more physical way is presented along with several other stimulating results and ideas from recent d+Au (p+Pb) measurements.« less

Simulations of the 2.5D inviscid primitive equations in a limited domain

NASA Astrophysics Data System (ADS)

Chen, Qingshan; Temam, Roger; Tribbia, Joseph J.

2008-12-01

The primitive equations (PEs) of the atmosphere and the oceans without viscosity are considered. These equations are not well-posed for any set of local boundary conditions. In space dimension 2.5 a set of nonlocal boundary conditions has been proposed in Chen et al. [Q. Chen, J. Laminie, A. Rousseau, R. Temam, J. Tribbia, A 2.5D Model for the equations of the ocean and the atmosphere, Anal. Appl. 5(3) (2007) 199-229]. The present article is aimed at testing the validity of these boundary conditions with physically relevant data. The issues tested are the well-posedness in the nonlinear case and the computational efficiency of the boundary conditions for limited area models [T.T. Warner, R.A. Peterson, R.E. Treadon, A tutorial on lateral boundary conditions as a basic and potentially serious limitation to regional numerical weather prediction, Bull. Amer. Meteor. Soc. 78(11) (1997) 2599-2617].

Extracting Spectroscopic Factors of Argon Isotopes from Transfer Reactions

NASA Astrophysics Data System (ADS)

Manfredi, Juan; Tsang, M. B.; Lynch, W. G.; Brown, K. W.; Cerizza, G.; Barney, J.; Estee, J.; Loelius, C.; Sweany, S.; Anderson, C.; Setiawan, H.; Winkelbauer, J.; Smith, K.; Lee, J.; Xu, Z.; Rogers, A.; Pruitt, C.; Chajecki, Z.; Chen, G.; Langer, C.; Xiao, Z.; Li, Z.; Niu, C.

2017-09-01

A spectroscopic factor (SF) quantifies the single particle structure of a given state in a nucleus. There is a discrepancy in extracted SF's between studies that use transfer reactions and those that use knockout reactions. Resolving this discrepancy is important both for understanding reaction probes as well as constraining nuclear structure theory. Kinematically complete measurements of the transfer reactions 34Ar(p,d) and 46Ar(p,d) were performed at the National Superconducting Cyclotron Laboratory. The same beam energy (70 MeV/u) was used as in a previous knockout measurement to account for energy dependence in the relevant optical potentials. Preliminary results will be presented. In addition, findings from measurement of the two-neutron transfer reactions 34Ar(p,t) and 4 6 Ar(p,t) will be discussed. This work was supported by the NSF (PHY 1565546) and the DOE NNSA Stewardship Science Graduate Fellowship.

Improving risk-stratification of Diabetes complications using temporal data mining.

PubMed

Sacchi, Lucia; Dagliati, Arianna; Segagni, Daniele; Leporati, Paola; Chiovato, Luca; Bellazzi, Riccardo

2015-01-01

To understand which factor trigger worsened disease control is a crucial step in Type 2 Diabetes (T2D) patient management. The MOSAIC project, funded by the European Commission under the FP7 program, has been designed to integrate heterogeneous data sources and provide decision support in chronic T2D management through patients' continuous stratification. In this work we show how temporal data mining can be fruitfully exploited to improve risk stratification. In particular, we exploit administrative data on drug purchases to divide patients in meaningful groups. The detection of drug consumption patterns allows stratifying the population on the basis of subjects' purchasing attitude. Merging these findings with clinical values indicates the relevance of the applied methods while showing significant differences in the identified groups. This extensive approach emphasized the exploitation of administrative data to identify patterns able to explain clinical conditions.

Impact of impurities on zonal flow driven by trapped electron mode turbulence

NASA Astrophysics Data System (ADS)

Guo, Weixin; Wang, Lu; Zhuang, Ge

2017-12-01

The impact of impurities on the generation of zonal flow (ZF) driven by collisonless trapped electron mode turbulence in deuterium (D)-tritium (T) plasmas is investigated. An expression for ZF growth rate with impurities is derived by balancing the ZF potential shielded by polarization effects and the ZF modulated radial turbulent current. Then, it is shown that the maximum normalized ZF growth rate is reduced by the presence of fully ionized non-trace light impurities with relatively flat density profile, and slightly reduced by highly ionized trace tungsten, while the maximum normalized ZF growth rate can be enhanced by fully ionized non-trace light impurities with relatively steep density profile. In particular, the effects of high temperature helium from D-T reaction on ZF depend on the temperature ratio between electrons and high temperature helium. The possible relevance of our findings to recent experimental results and future burning plasmas is also discussed.

Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs.

PubMed

Szymanski, Eric S; Kimsey, Isaac J; Al-Hashimi, Hashim M

2017-03-29

The replicative and translational machinery utilizes the unique geometry of canonical G·C and A·T/U Watson-Crick base pairs to discriminate against DNA and RNA mismatches in order to ensure high fidelity replication, transcription, and translation. There is growing evidence that spontaneous errors occur when mismatches adopt a Watson-Crick-like geometry through tautomerization and/or ionization of the bases. Studies employing NMR relaxation dispersion recently showed that wobble dG·dT and rG·rU mismatches in DNA and RNA duplexes transiently form tautomeric and anionic species with probabilities (≈0.01-0.40%) that are in concordance with replicative and translational errors. Although computational studies indicate that these exceptionally short-lived and low-abundance species form Watson-Crick-like base pairs, their conformation could not be directly deduced from the experimental data, and alternative pairing geometries could not be ruled out. Here, we report direct NMR evidence that the transient tautomeric and anionic species form hydrogen-bonded Watson-Crick-like base pairs. A guanine-to-inosine substitution, which selectively knocks out a Watson-Crick-type (G)N2H 2 ···O2(T) hydrogen bond, significantly destabilized the transient tautomeric and anionic species, as assessed by lack of any detectable chemical exchange by imino nitrogen rotating frame spin relaxation (R 1ρ ) experiments. An 15 N R 1ρ NMR experiment targeting the amino nitrogen of guanine (dG-N2) provides direct evidence for Watson-Crick (G)N2H 2 ···O2(T) hydrogen bonding in the transient tautomeric state. The strategy presented in this work can be generally applied to examine hydrogen-bonding patterns in nucleic acid transient states including in other tautomeric and anionic species that are postulated to play roles in replication and translational errors.

Improving the resolution in proton-detected through-space heteronuclear multiple quantum correlation NMR spectroscopy.

PubMed

Shen, Ming; Trébosc, J; Lafon, O; Pourpoint, F; Hu, Bingwen; Chen, Qun; Amoureux, J-P

2014-08-01

Connectivities and proximities between protons and low-gamma nuclei can be probed in solid-state NMR spectroscopy using two-dimensional (2D) proton-detected heteronuclear correlation, through Heteronuclear Multiple Quantum Correlation (HMQC) pulse sequence. The indirect detection via protons dramatically enhances the sensitivity. However, the spectra are often broadened along the indirect F1 dimension by the decay of heteronuclear multiple-quantum coherences under the strong (1)H-(1)H dipolar couplings. This work presents a systematic comparison of the performances of various decoupling schemes during the indirect t1 evolution period of dipolar-mediated HMQC (D-HMQC) experiment. We demonstrate that (1)H-(1)H dipolar decoupling sequences during t1, such as symmetry-based schemes, phase-modulated Lee-Goldburg (PMLG) and Decoupling Using Mind-Boggling Optimization (DUMBO), provide better resolution than continuous wave (1)H irradiation. We also report that high resolution requires the preservation of (1)H isotropic chemical shifts during the decoupling sequences. When observing indirectly broad spectra presenting numerous spinning sidebands, the D-HMQC sequence must be fully rotor-synchronized owing to the rotor-synchronized indirect sampling and dipolar recoupling sequence employed. In this case, we propose a solution to reduce artefact sidebands caused by the modulation of window delays before and after the decoupling application during the t1 period. Moreover, we show that (1)H-(1)H dipolar decoupling sequence using Smooth Amplitude Modulation (SAM) minimizes the t1-noise. The performances of the various decoupling schemes are assessed via numerical simulations and compared to 2D (1)H-{(13)C} D-HMQC experiments on [U-(13)C]-L-histidine⋅HCl⋅H2O at various magnetic fields and Magic Angle spinning (MAS) frequencies. Great resolution and sensitivity enhancements resulting from decoupling during t1 period enable the detection of heteronuclear correlation between aliphatic protons and ammonium (14)N sites in L-histidine⋅HCl⋅H2O. Copyright © 2014 Elsevier Inc. All rights reserved.

Effect of sound on boundary layer stability

NASA Technical Reports Server (NTRS)

Saric, William S. (Principal Investigator); Spencer, Shelly Anne

1993-01-01

Experiments are conducted in the Arizona State University Unsteady Wind Tunnel with a zero-pressure-gradient flat-plate model that has a 67:1 elliptical leading edge. Boundary-layer measurements are made of the streamwise fluctuating-velocity component in order to identify the amplified T-S waves that are forced by downstream-travelling, sound waves. Measurements are taken with circular 3-D roughness elements placed at the Branch 1 neutral stability point for the frequency under consideration, and then with the roughness element downstream of Branch 1. These roughness elements have a principal chord dimension equal to 2(lambda)(sub TS)/pi, of the T-S waves under study and are 'stacked' in order to resemble a Gaussian height distribution. Measurements taken just downstream of the roughness (with leading-edge T-S waves, surface roughness T-S waves, instrumentation sting vibrations and the Stokes wave subtracted) show the generation of 3-D-T-S waves, but not in the characteristic heart-shaped disturbance field predicted by 3-D asymptotic theory. Maximum disturbance amplitudes are found on the roughness centerline. However, some near-field characteristics predicted by numerical modelling are observed.

Effect of sound on boundary layer stability

NASA Technical Reports Server (NTRS)

Saric, William S.; Spencer, Shelly Anne

1993-01-01

Experiments are conducted in the Arizona State University Unsteady Wind Tunnel with a zero-pressure-gradient flat-plate model that has a 67:1 elliptical leading edge. Boundary-layer measurements are made of the streamwise fluctuating-velocity component in order to identify the amplified T-S waves that are forced by downstream-traveling sound waves. Measurements are taken with circular 3-D roughness elements placed at the Branch 1 neutral stability point for the frequency under consideration, and then with the roughness element downstream of Branch 1. These roughness elements have a principal chord dimension equal to 2 lambda(sub TS)/pi of the T-S waves under study and are 'stacked' in order to resemble a Gaussian height distribution. Measurements taken just downstream of the roughness (with leading-edge T-S waves, surface roughness T-S waves, instrumentation sting vibrations, and the Stokes wave subtracted) show the generation of 3-D T-S waves, but not in the characteristic heart-shaped disturbance field predicted by 3-D asymptotic theory. Maximum disturbance amplitudes are found on the roughness centerline. However, some near-field characteristics predicted by numerical modeling are observed.

Suppression of high-pT hadrons in Pb+Pb collisions at energies available at the CERN Large Hadron Collider

NASA Astrophysics Data System (ADS)

Chen, Xiao-Fang; Hirano, Tetsufumi; Wang, Enke; Wang, Xin-Nian; Zhang, Hanzhong

2011-09-01

The nuclear modification factor RAA(pT) for large transverse momentum pion spectra in Pb+Pb collisions at s=2.76 TeV is predicted within the next-to-leading order perturbative QCD parton model. The effect of jet quenching is incorporated through medium-modified fragmentation functions within the higher-twist approach. The jet transport parameter that controls medium modification is proportional to the initial parton density, and the coefficient is fixed by data on the suppression of large-pT hadron spectra obtained at the BNL Relativistic Heavy Ion Collider. Data on charged hadron multiplicity dNch/dη=1584±80 in central Pb+Pb collisions from the ALICE experiment at the CERN Large Hadron Collider are used to constrain the initial parton density both for determining the jet transport parameter and the 3 + 1 dimensional (3 + 1D) ideal hydrodynamic evolution of the bulk matter that is employed for the calculation of RPbPb(pT) for neutral pions.

Role of the third strand in the binding of proflavine and pt-proflavine to poly(rA).2poly(rU): a thermodynamic and kinetic study.

PubMed

García, Begoña; Leal, José M; Paiotta, Vittorio; Ruiz, Rebeca; Secco, Fernando; Venturini, Marcella

2008-06-12

The interactions of triple strands of poly(rA).2poly(rU) with proflavine (PR) and the proflavine cis-platinum derivative [{PtCl (tmen)} 2{NC 13H 7(NCH 2CH 2) 2}] (+) (PRPt) are examined at pH 7.0, T = 25 degrees C, and 0.2 M ionic strength by spectrophotometry, spectrofluorometry, circular dichroism, viscosimetry, stopped-flow, and T-jump relaxation techniques. The melting experiments demonstrate that both drugs tend to destabilize the triplex structure, although the PRPt effect is more relevant. By contrast, both drugs tend to slightly stabilize the duplex structure. The viscosity and circular dichroism measurements show that, at a low dye-to-polymer ratio ( C D/ C P), the binding is intercalative, whereas at high C D/ C P values, the external binding dominates. The binding kinetics and equilibria have been investigated over the C D/ C P region, where intercalation is operative. Both drugs bind to the RNA triplex according to the excluded site model. With PR, two kinetic effects have been observed, whereas with PRPt, only one has been observed. The results are interpreted according to the reaction schemes D + S right arrow over left arrow DS I, with PRPt, and D + S right arrow over left arrow DS I right arrow over left arrow DS II, with PR. The electrostatic contribution to the formation activation energy for DS I is similar (40%) for both systems. The results suggest that DS I is a partially intercalated species. Absence of the second step with PRPt is put down to groove interaction of the Pt-containing moiety, which prevents the PR residue from further penetration through the base pairs to form the fully intercalated complex, DS II. Comparison with the binding of the same drugs to the duplex reveals that the occupation of the major groove in poly(rA).2poly(rU) by the third strand plays a critical role in the kinetic behavior.

Determination of linear viscoelastic properties of an entangled polymer melt by probe rheology simulations.

PubMed

Karim, Mir; Indei, Tsutomu; Schieber, Jay D; Khare, Rajesh

2016-01-01

Particle rheology is used to extract the linear viscoelastic properties of an entangled polymer melt from molecular dynamics simulations. The motion of a stiff, approximately spherical particle is tracked in both passive and active modes. We demonstrate that the dynamic modulus of the melt can be extracted under certain limitations using this technique. As shown before for unentangled chains [Karim et al., Phys. Rev. E 86, 051501 (2012)PLEEE81539-375510.1103/PhysRevE.86.051501], the frequency range of applicability is substantially expanded when both particle and medium inertia are properly accounted for by using our inertial version of the generalized Stokes-Einstein relation (IGSER). The system used here introduces an entanglement length d_{T}, in addition to those length scales already relevant: monomer bead size d, probe size R, polymer radius of gyration R_{g}, simulation box size L, shear wave penetration length Δ, and wave period Λ. Previously, we demonstrated a number of restrictions necessary to obtain the relevant fluid properties: continuum approximation breaks down when d≳Λ; medium inertia is important and IGSER is required when R≳Λ; and the probe should not experience hydrodynamic interaction with its periodic images, L≳Δ. These restrictions are also observed here. A simple scaling argument for entangled polymers shows that the simulation box size must scale with polymer molecular weight as M_{w}^{3}. Continuum analysis requires the existence of an added mass to the probe particle from the entrained medium but was not observed in the earlier work for unentangled chains. We confirm here that this added mass is necessary only when the thickness L_{S} of the shell around the particle that contains the added mass, L_{S}>d. We also demonstrate that the IGSER can be used to predict particle displacement over a given timescale from knowledge of medium viscoelasticity; such ability will be of interest for designing nanoparticle-based drug delivery.

Theoretical and numerical study of axisymmetric lattice Boltzmann models

NASA Astrophysics Data System (ADS)

Huang, Haibo; Lu, Xi-Yun

2009-07-01

The forcing term in the lattice Boltzmann equation (LBE) is usually used to mimic Navier-Stokes equations with a body force. To derive axisymmetric model, forcing terms are incorporated into the two-dimensional (2D) LBE to mimic the additional axisymmetric contributions in 2D Navier-Stokes equations in cylindrical coordinates. Many axisymmetric lattice Boltzmann D2Q9 models were obtained through the Chapman-Enskog expansion to recover the 2D Navier-Stokes equations in cylindrical coordinates [I. Halliday , Phys. Rev. E 64, 011208 (2001); K. N. Premnath and J. Abraham, Phys. Rev. E 71, 056706 (2005); T. S. Lee, H. Huang, and C. Shu, Int. J. Mod. Phys. C 17, 645 (2006); T. Reis and T. N. Phillips, Phys. Rev. E 75, 056703 (2007); J. G. Zhou, Phys. Rev. E 78, 036701 (2008)]. The theoretical differences between them are discussed in detail. Numerical studies were also carried out by simulating two different flows to make a comparison on these models’ accuracy and τ sensitivity. It is found all these models are able to obtain accurate results and have the second-order spatial accuracy. However, the model C [J. G. Zhou, Phys. Rev. E 78, 036701 (2008)] is the most stable one in terms of τ sensitivity. It is also found that if density of fluid is defined in its usual way and not directly relevant to source terms, the lattice Boltzmann model seems more stable.

Toxic effects of dietary methylmercury on immune system development in nestling American kestrels (Falco sparverius)

USGS Publications Warehouse

Fallacara, Dawn M.; Halbrook, Richard S.; French, John B.

2011-01-01

This study evaluated the effects of dietary methylmercury (MeHg) on immune system development in captive-reared nestling American kestrels (Falco sparverius) to determine whether T cell–mediated and antibody-mediated adaptive immunity are targets for MeHg toxicity at environmentally relevant concentrations. Nestlings received various diets, including 0 (control), 0.6, and 3.9 μg/g (dry wt) MeHg for up to 18 d posthatch. Immunotoxicity endpoints included cell-mediated immunity (CMI) using the phytohemagglutinin (PHA) skin-swelling assay and antibody-mediated immune response via the sheep red blood cell (SRBC) hemagglutination assay. T cell– and B cell–dependent histological parameters in the spleen, thymus, and bursa of Fabricius were correlated with the functional assays. For nestlings in the 0.6 and 3.9 μg/g MeHg groups, CMI was suppressed by 73 and 62%, respectively, at 11 d of age. Results of this functional assay were correlated with T cell–dependent components of the spleen and thymus. Dose-dependent lymphoid depletion in spleen tissue directly affected the proliferation of T-lymphocyte populations, insofar as lower stimulation indexes from the PHA assay occurred in nestlings with lower proportions of splenic white pulp and higher THg concentrations. Nestlings in the 3.9 μg/g group also exhibited lymphoid depletion and a lack of macrophage activity in the thymus. Methylmercury did not have a noticeable effect on antibody-mediated immune function or B cell–dependent histological correlates. We conclude that T cell–mediated immunosuppression is the primary target of MeHg toward adaptive immunity in developing kestrels. This study provides evidence that environmentally relevant concentrations of MeHg may compromise immunocompetence in a developing terrestrial predator and raises concern regarding the long-term health effects of kestrels that were exposed to dietary MeHg during early avian development.

Through-Thickness Vertically Ordered Lamellar Block Copolymer Thin Films on Unmodified Quartz with Cold Zone Annealing [Thru-Thickness Vertically Ordered Lamellar Block Copolymer Thin Films on Unmodified Quartz with Cold Zone Annealing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basutkar, Monali N.; Samant, Saumil; Strzalka, Joseph

Here, template-free directed self-assembly of ultrathin (~10’s nm) lamellar block copolymer (l-BCP) films of high-interfacial area into vertically oriented nanodomains holds much technological relevance for fabrication of next-generation devices from nanoelectronics to nanomembranes due to domain interconnectivity and high interfacial area. We report for the first time, the formation of full thru-thickness vertically oriented lamellar domains in 100 nm thin polystyrene- block-poly(methyl methacrylate) (PS- b-PMMA) films on quartz substrate, achieved without any PMMA-block wetting layer formation, quartz surface modification (templating chemical, topographical) or system modifications (added surfactant, top-layer coat). Vertical ordering of l-BCPs results from the coupling between a molecularmore » and a macroscopic phenomenon. A molecular relaxation induced vertical l-BCP ordering occurs under a transient macroscopic vertical strain field, imposed by a high film thermal expansion rate under sharp thermal gradient cold zone annealing (CZA-S). The parametric window for vertical ordering is quantified via a coupling constant, C (= v∇ T), whose range is established in terms of a thermal gradient (∇ T) above a threshold value, and an optimal dynamic sample sweep rate ( v ~ d/τ), where τ is the l-BCP’s longest molecular relaxation time and d is the T g,heat- T g,cool distance. Real-time CZA-S morphology evolution of vertically oriented l-BCP tracked along ∇ T using in-situ Grazing Incidence Small Angle X-ray Scattering exhibited an initial formation phase of vertical lamellae, a polygrain structure formation stage, and a grain coarsening phase to fully vertically ordered l-BCP morphology development. CZA-S is a roll-to-roll manufacturing method, rendering this template-free thru-thickness vertical ordering of l-BCP films highly attractive and industrially relevant.« less

Through-Thickness Vertically Ordered Lamellar Block Copolymer Thin Films on Unmodified Quartz with Cold Zone Annealing [Thru-Thickness Vertically Ordered Lamellar Block Copolymer Thin Films on Unmodified Quartz with Cold Zone Annealing

DOE PAGES

Basutkar, Monali N.; Samant, Saumil; Strzalka, Joseph; ...

2017-11-14

Here, template-free directed self-assembly of ultrathin (~10’s nm) lamellar block copolymer (l-BCP) films of high-interfacial area into vertically oriented nanodomains holds much technological relevance for fabrication of next-generation devices from nanoelectronics to nanomembranes due to domain interconnectivity and high interfacial area. We report for the first time, the formation of full thru-thickness vertically oriented lamellar domains in 100 nm thin polystyrene- block-poly(methyl methacrylate) (PS- b-PMMA) films on quartz substrate, achieved without any PMMA-block wetting layer formation, quartz surface modification (templating chemical, topographical) or system modifications (added surfactant, top-layer coat). Vertical ordering of l-BCPs results from the coupling between a molecularmore » and a macroscopic phenomenon. A molecular relaxation induced vertical l-BCP ordering occurs under a transient macroscopic vertical strain field, imposed by a high film thermal expansion rate under sharp thermal gradient cold zone annealing (CZA-S). The parametric window for vertical ordering is quantified via a coupling constant, C (= v∇ T), whose range is established in terms of a thermal gradient (∇ T) above a threshold value, and an optimal dynamic sample sweep rate ( v ~ d/τ), where τ is the l-BCP’s longest molecular relaxation time and d is the T g,heat- T g,cool distance. Real-time CZA-S morphology evolution of vertically oriented l-BCP tracked along ∇ T using in-situ Grazing Incidence Small Angle X-ray Scattering exhibited an initial formation phase of vertical lamellae, a polygrain structure formation stage, and a grain coarsening phase to fully vertically ordered l-BCP morphology development. CZA-S is a roll-to-roll manufacturing method, rendering this template-free thru-thickness vertical ordering of l-BCP films highly attractive and industrially relevant.« less

Modeling T1 and T2 relaxation in bovine white matter

NASA Astrophysics Data System (ADS)

Barta, R.; Kalantari, S.; Laule, C.; Vavasour, I. M.; MacKay, A. L.; Michal, C. A.

2015-10-01

The fundamental basis of T1 and T2 contrast in brain MRI is not well understood; recent literature contains conflicting views on the nature of relaxation in white matter (WM). We investigated the effects of inversion pulse bandwidth on measurements of T1 and T2 in WM. Hybrid inversion-recovery/Carr-Purcell-Meiboom-Gill experiments with broad or narrow bandwidth inversion pulses were applied to bovine WM in vitro. Data were analysed with the commonly used 1D-non-negative least squares (NNLS) algorithm, a 2D-NNLS algorithm, and a four-pool model which was based upon microscopically distinguishable WM compartments (myelin non-aqueous protons, myelin water, non-myelin non-aqueous protons and intra/extracellular water) and incorporated magnetization exchange between adjacent compartments. 1D-NNLS showed that different T2 components had different T1 behaviours and yielded dissimilar results for the two inversion conditions. 2D-NNLS revealed significantly more complicated T1/T2 distributions for narrow bandwidth than for broad bandwidth inversion pulses. The four-pool model fits allow physical interpretation of the parameters, fit better than the NNLS techniques, and fits results from both inversion conditions using the same parameters. The results demonstrate that exchange cannot be neglected when analysing experimental inversion recovery data from WM, in part because it can introduce exponential components having negative amplitude coefficients that cannot be correctly modeled with nonnegative fitting techniques. While assignment of an individual T1 to one particular pool is not possible, the results suggest that under carefully controlled experimental conditions the amplitude of an apparent short T1 component might be used to quantify myelin water.

The effect of feeding calcium- and phosphorus-deficient diets to broiler chickens during the starting and growing-finishing phases on carcass quality.

PubMed

Driver, J P; Pesti, G M; Bakalli, R I; Edwards, H M

2006-11-01

There is considerable data on the effect of reducing inorganic Ca and P in broiler finisher diets on carcass quality. However, there is limited information on the effect of reducing dietary Ca and P during the different phases of growout. Two experiments were conducted from 0 to 35 d in floor pens. In both experiments, at least 4 replicates per treatment (50 chicks per replicate) were used. Corn-soybean meal and soybean oil-based diets deficient in Ca and P were fed. During the starter phase (ST), from 0 to 18 d, chicks were fed a 23% CP diet containing 0.60% Ca and 0.47% total P (tP). During the grower-finisher phase (GF), from 19 to 35 d, birds were fed a 19% CP diet containing 0.30% Ca and 0.37% tP. A combination of 1,000 phytase units/kg of Natuphos phytase and 5 microg/kg of 1alpha-hydroxycholecalciferol (P + 1alpha) was supplemented to some of the feed during the ST and GF. Diets containing adequate Ca and P were also fed during the ST (0.90% Ca and 0.68% tP) and GF (0.80% Ca and 0.67% tP). The level of tibia ash and the incidence of bone disease were measured at 18 and 35 d. At the end of the experiments, birds were processed and evaluated for muscle hemorrhages and broken bones. In both experiments, broilers fed diets that were not P + 1alpha supplemented demonstrated poor bone mineralization, considerable leg problems, and a high incidence of broken bones after processing. Broilers fed P + 1alpha throughout had more broken clavicles and femurs compared with birds fed the adequate diets. Day-18 tibia ash was significantly correlated to broken tibias and femurs during processing. Day-35 tibia ash was better correlated to bloody breast meat than to broken bones. It is concluded that carcass quality depends on the levels of Ca and P fed and the age of the bird. Tibia ash, traditionally used as an indication of bone strength, was better correlated to the incidence of bloody breasts.

Toward real-time temperature monitoring in fat and aqueous tissue during magnetic resonance-guided high-intensity focused ultrasound using a three-dimensional proton resonance frequency T1 method.

PubMed

Diakite, Mahamadou; Odéen, Henrik; Todd, Nick; Payne, Allison; Parker, Dennis L

2014-07-01

To present a three-dimensional (3D) segmented echoplanar imaging (EPI) pulse sequence implementation that provides simultaneously the proton resonance frequency shift temperature of aqueous tissue and the longitudinal relaxation time (T1 ) of fat during thermal ablation. The hybrid sequence was implemented by combining a 3D segmented flyback EPI sequence, the extended two-point Dixon fat and water separation, and the double flip angle T1 mapping techniques. High-intensity focused ultrasound (HIFU) heating experiments were performed at three different acoustic powers on excised human breast fat embedded in ex vivo porcine muscle. Furthermore, T1 calibrations with temperature in four different excised breast fat samples were performed, yielding an estimate of the average and variation of dT1 /dT across subjects. The water only images were used to mask the complex original data before computing the proton resonance frequency shift. T1 values were calculated from the fat-only images. The relative temperature coefficients were found in five fat tissue samples from different patients and ranged from 1.2% to 2.6%/°C. The results demonstrate the capability of real-time simultaneous temperature mapping in aqueous tissue and T1 mapping in fat during HIFU ablation, providing a potential tool for treatment monitoring in organs with large fat content, such as the breast. Copyright © 2013 Wiley Periodicals, Inc.

Naval Postgraduate School Research. Volume 10, Number 2, June 2000

DTIC Science & Technology

2000-06-01

Associate Provost and Dean of Research Dr. David W. Netzer R E S E A R C H N A V A L P O S T G R A D U A T E S C H O O L Introduction The past two...capture during the execution phase of Fleet Battle Experiment Golf (FBE- G ). Fleet Battle Experiment Golf was conducted by Sixth Fleet and the Maritime...in FBE- G . The National Security Telecommunications and Information Systems Security Committee (NSTISSC) and the National Security Agency has certified

Nuclear science experiments with a bright neutron source from fusion reactions on the OMEGA Laser System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forrest, C. J.; Knauer, J. P.; Schroeder, W. U.

Subnanosecond impulses of 10 13 to 10 14 neutrons, produced in direct-drive laser inertial confinement fusion implosions, have been used to irradiate deuterated targets at the OMEGA Laser System [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)]. The target compounds include heavy water (D 2O) and deuterated benzene (C 6D 6). Yields and energy spectra of neutrons from D(n,2n)p to study the breakup reaction have been measured at a forward angle of θlab = 3.5 degrees plus/minus 3.5 degrees with a sensitive, high-dynamic-range neutron time-of-flight spectrometer to infer the double-differential breakup cross section d2sigma/dEdomega for 14-MeV D–T fusionmore » neutrons.« less

Nuclear science experiments with a bright neutron source from fusion reactions on the OMEGA Laser System

DOE PAGES

Forrest, C. J.; Knauer, J. P.; Schroeder, W. U.; ...

2018-01-31

Subnanosecond impulses of 10 13 to 10 14 neutrons, produced in direct-drive laser inertial confinement fusion implosions, have been used to irradiate deuterated targets at the OMEGA Laser System [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)]. The target compounds include heavy water (D 2O) and deuterated benzene (C 6D 6). Yields and energy spectra of neutrons from D(n,2n)p to study the breakup reaction have been measured at a forward angle of θlab = 3.5 degrees plus/minus 3.5 degrees with a sensitive, high-dynamic-range neutron time-of-flight spectrometer to infer the double-differential breakup cross section d2sigma/dEdomega for 14-MeV D–T fusionmore » neutrons.« less

Top Quark Properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peters, Yvonne

2011-12-01

Since its discovery in 1995 by the CDF and D0 collaborations at the Fermilab Tevatron collider, the top quark has undergone intensive studies. Besides the Tevatron experiments, with the start of the LHC in 2010 a top quark factory started its operation. It is now possible to measure top quark properties simultaneously at four different experiments, namely ATLAS and CMS at LHC and CDF and D0 at Tevatron. Having collected thousands of top quarks each, several top quark properties have been measured precisely, while others are being measured for the first time. In this article, recent measurements of top quarkmore » properties from ATLAS, CDF, CMS and D0 are presented, using up to 5.4 fb{sup -1} of integrated luminosity at the Tevatron and 1.1 fb{sup -1} at the LHC. In particular, measurements of the top quark mass, mass difference, foward backward charge asymmetry, t{bar t} spin correlations, the ratio of branching fractions, W helicity, anomalous couplings, color flow and the search for flavor changing neutral currents are discussed.« less

Laser experiments to simulate coronal mass ejection driven magnetospheres and astrophysical plasma winds on compact magnetized stars

NASA Astrophysics Data System (ADS)

Horton, W.; Ditmire, T.; Zakharov, Yu. P.

2010-06-01

Laboratory experiments using a plasma wind generated by laser-target interaction are proposed to investigate the creation of a shock in front of the magnetosphere and the dynamo mechanism for creating plasma currents and voltages. Preliminary experiments are shown where measurements of the electron density gradients surrounding the obstacles are recorded to infer the plasma winds. The proposed experiments are relevant to understanding the electron acceleration mechanisms taking place in shock-driven magnetic dipole confined plasmas surrounding compact magnetized stars and planets. Exploratory experiments have been published [P. Brady, T. Ditmire, W. Horton, et al., Phys. Plasmas 16, 043112 (2009)] with the one Joule Yoga laser and centimeter sized permanent magnets.

237Np absolute delayed neutron yield measurements

NASA Astrophysics Data System (ADS)

Doré, D.; Ledoux, X.; Nolte, R.; Gagnon-Moisan, F.; Thulliez, L.; Litaize, O.; Roettger, S.; Serot, O.

2017-09-01

237Np absolute delayed neutron yields have been measured at different incident neutron energies from 1.5 to 16 MeV. The experiment was performed at the Physikalisch-Technische Bundesanstalt (PTB) facility where the Van de Graaff accelerator and the cyclotron CV28 delivered 9 different neutron energy beams using p+T, d+D and d+T reactions. The detection system is made up of twelve 3He tubes inserted into a polyethylene cylinder. In this paper, the experimental setup and the data analysis method are described. The evolution of the absolute DN yields as a function of the neutron incident beam energies are presented and compared to experimental data found in the literature and data from the libraries.

76 FR 19386 - Jacobo Dreszer, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... (quoting 21 CFR 1306.04(a)), and that ``the evidence under the [experience] * * * factor[] support[s]'' the revocation of his registration, is consistent with Agency precedent. Id. With respect to factor five, ``[s... that ``an adverse finding under this factor requires some showing that the relevant conduct actually...