Mitigation of X-ray damage in macromolecular crystallography by submicrometre line focusing.

PubMed

Finfrock, Y Zou; Stern, Edward A; Alkire, R W; Kas, Joshua J; Evans-Lutterodt, Kenneth; Stein, Aaron; Duke, Norma; Lazarski, Krzysztof; Joachimiak, Andrzej

2013-08-01

Reported here are measurements of the penetration depth and spatial distribution of photoelectron (PE) damage excited by 18.6 keV X-ray photons in a lysozyme crystal with a vertical submicrometre line-focus beam of 0.7 µm full-width half-maximum (FWHM). The experimental results determined that the penetration depth of PEs is 5 ± 0.5 µm with a monotonically decreasing spatial distribution shape, resulting in mitigation of diffraction signal damage. This does not agree with previous theoretical predication that the mitigation of damage requires a peak of damage outside the focus. A new improved calculation provides some qualitative agreement with the experimental results, but significant errors still remain. The mitigation of radiation damage by line focusing was measured experimentally by comparing the damage in the X-ray-irradiated regions of the submicrometre focus with the large-beam case under conditions of equal exposure and equal volumes of the protein crystal, and a mitigation factor of 4.4 ± 0.4 was determined. The mitigation of radiation damage is caused by spatial separation of the dominant PE radiation-damage component from the crystal region of the line-focus beam that contributes the diffraction signal. The diffraction signal is generated by coherent scattering of incident X-rays (which introduces no damage), while the overwhelming proportion of damage is caused by PE emission as X-ray photons are absorbed.

Integrated health management and control of complex dynamical systems

NASA Astrophysics Data System (ADS)

Tolani, Devendra K.

2005-11-01

A comprehensive control and health management strategy for human-engineered complex dynamical systems is formulated for achieving high performance and reliability over a wide range of operation. Results from diverse research areas such as Probabilistic Robust Control (PRC), Damage Mitigating/Life Extending Control (DMC), Discrete Event Supervisory (DES) Control, Symbolic Time Series Analysis (STSA) and Health and Usage Monitoring System (HUMS) have been employed to achieve this goal. Continuous-domain control modules at the lower level are synthesized by PRC and DMC theories, whereas the upper-level supervision is based on DES control theory. In the PRC approach, by allowing different levels of risk under different flight conditions, the control system can achieve the desired trade off between stability robustness and nominal performance. In the DMC approach, component damage is incorporated in the control law to reduce the damage rate for enhanced structural durability. The DES controller monitors the system performance and, based on the mission requirements (e.g., performance metrics and level of damage mitigation), switches among various lower-level controllers. The core idea is to design a framework where the DES controller at the upper-level, mimics human intelligence and makes appropriate decisions to satisfy mission requirements, enhance system performance and structural durability. Recently developed tools in STSA have been used for anomaly detection and failure prognosis. The DMC deals with the usage monitoring or operational control part of health management, where as the issue of health monitoring is addressed by the anomaly detection tools. The proposed decision and control architecture has been validated on two test-beds, simulating the operations of rotorcraft dynamics and aircraft propulsion.

Tailoring the Employment of Offshore Wind Turbine Support Structure Load Mitigation Controllers

NASA Astrophysics Data System (ADS)

Shrestha, Binita; Kühn, Martin

2016-09-01

The currently available control concepts to mitigate aerodynamic and hydrodynamic induced support structure loads reduce either fore-aft or side-to-side damage under certain operational conditions. The load reduction is achieved together with an increase in loads in other components of the turbine e.g. pitch actuators or drive train, increasing the risk of unscheduled maintenance. The main objective of this paper is to demonstrate a methodology for reduction of support structure damage equivalent loads (DEL) in fore-aft and side-to-side directions using already available control concepts. A multi-objective optimization problem is formulated to minimize the DELs, while limiting the collateral effects of the control algorithms for load reduction. The optimization gives trigger values of sea state condition for the activation or deactivation of certain control concepts. As a result, by accepting the consumption of a small fraction of the load reserve in the design load envelope of other turbine components, a considerable reduction of the support structure loads is facilitated.

Theory of runaway electrons in ITER: Equations, important parameters, and implications for mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boozer, Allen H., E-mail: ahb17@columbia.edu

2015-03-15

The plasma current in ITER cannot be allowed to transfer from thermal to relativistic electron carriers. The potential for damage is too great. Before the final design is chosen for the mitigation system to prevent such a transfer, it is important that the parameters that control the physics be understood. Equations that determine these parameters and their characteristic values are derived. The mitigation benefits of the injection of impurities with the highest possible atomic number Z and the slowing plasma cooling during halo current mitigation to ≳40 ms in ITER are discussed. The highest possible Z increases the poloidal flux consumptionmore » required for each e-fold in the number of relativistic electrons and reduces the number of high energy seed electrons from which exponentiation builds. Slow cooling of the plasma during halo current mitigation also reduces the electron seed. Existing experiments could test physics elements required for mitigation but cannot carry out an integrated demonstration. ITER itself cannot carry out an integrated demonstration without excessive danger of damage unless the probability of successful mitigation is extremely high. The probability of success depends on the reliability of the theory. Equations required for a reliable Monte Carlo simulation are derived.« less

Advanced Mitigation Process (AMP) for Improving Laser Damage Threshold of Fused Silica Optics

NASA Astrophysics Data System (ADS)

Ye, Xin; Huang, Jin; Liu, Hongjie; Geng, Feng; Sun, Laixi; Jiang, Xiaodong; Wu, Weidong; Qiao, Liang; Zu, Xiaotao; Zheng, Wanguo

2016-08-01

The laser damage precursors in subsurface of fused silica (e.g. photosensitive impurities, scratches and redeposited silica compounds) were mitigated by mineral acid leaching and HF etching with multi-frequency ultrasonic agitation, respectively. The comparison of scratches morphology after static etching and high-frequency ultrasonic agitation etching was devoted in our case. And comparison of laser induce damage resistance of scratched and non-scratched fused silica surfaces after HF etching with high-frequency ultrasonic agitation were also investigated in this study. The global laser induce damage resistance was increased significantly after the laser damage precursors were mitigated in this case. The redeposition of reaction produce was avoided by involving multi-frequency ultrasonic and chemical leaching process. These methods made the increase of laser damage threshold more stable. In addition, there is no scratch related damage initiations found on the samples which were treated by Advanced Mitigation Process.

Advanced Mitigation Process (AMP) for Improving Laser Damage Threshold of Fused Silica Optics

PubMed Central

Ye, Xin; Huang, Jin; Liu, Hongjie; Geng, Feng; Sun, Laixi; Jiang, Xiaodong; Wu, Weidong; Qiao, Liang; Zu, Xiaotao; Zheng, Wanguo

2016-01-01

The laser damage precursors in subsurface of fused silica (e.g. photosensitive impurities, scratches and redeposited silica compounds) were mitigated by mineral acid leaching and HF etching with multi-frequency ultrasonic agitation, respectively. The comparison of scratches morphology after static etching and high-frequency ultrasonic agitation etching was devoted in our case. And comparison of laser induce damage resistance of scratched and non-scratched fused silica surfaces after HF etching with high-frequency ultrasonic agitation were also investigated in this study. The global laser induce damage resistance was increased significantly after the laser damage precursors were mitigated in this case. The redeposition of reaction produce was avoided by involving multi-frequency ultrasonic and chemical leaching process. These methods made the increase of laser damage threshold more stable. In addition, there is no scratch related damage initiations found on the samples which were treated by Advanced Mitigation Process. PMID:27484188

Alleviating inequality in climate policy costs: an integrated perspective on mitigation, damage and adaptation

NASA Astrophysics Data System (ADS)

De Cian, E.; Hof, A. F.; Marangoni, G.; Tavoni, M.; van Vuuren, D. P.

2016-07-01

Equity considerations play an important role in international climate negotiations. While policy analysis has often focused on equity as it relates to mitigation costs, there are large regional differences in adaptation costs and the level of residual damage. This paper illustrates the relevance of including adaptation and residual damage in equity considerations by determining how the allocation of emission allowances would change to counteract regional differences in total climate costs, defined as the costs of mitigation, adaptation, and residual damage. We compare emission levels resulting from a global carbon tax with two allocations of emission allowances under a global cap-and-trade system: one equating mitigation costs and one equating total climate costs as share of GDP. To account for uncertainties in both mitigation and adaptation, we use a model-comparison approach employing two alternative modeling frameworks with different damage, adaptation cost, and mitigation cost estimates, and look at two different climate goals. Despite the identified model uncertainties, we derive unambiguous results on the change in emission allowance allocation that could lessen the unequal distribution of adaptation costs and residual damages through the financial transfers associated with emission trading.

Climate, Health, Agricultural and Economic Impacts of Tighter Vehicle-Emission Standards

NASA Technical Reports Server (NTRS)

Shindell, Drew; Faluvegi, Greg; Walsh, Michael; Anenberg, Susan C.; VanDingen, Rita; Muller, Nicholas Z.; Austin, Jeff; Koch, Dorothy; Milly, George

2011-01-01

Non-CO2 air pollutants from motor vehicles have traditionally been controlled to protect air quality and health, but also affect climate. We use global composition climate modelling to examine the integrated impacts of adopting stringent European on-road vehicle-emission standards for these pollutants in 2015 in many developing countries. Relative to no extra controls, the tight standards lead to annual benefits in 2030 and beyond of 120,000-280,000 avoided premature air pollution-related deaths, 6.1-19.7 million metric tons of avoided ozone-related yield losses of major food crops, $US0.6-2.4 trillion avoided health damage and $US1.1-4.3 billion avoided agricultural damage, and mitigation of 0.20 (+0.14/-0.17) C of Northern Hemisphere extratropical warming during 2040-2070. Tighter vehicle-emission standards are thus extremely likely to mitigate short-term climate change in most cases, in addition to providing large improvements in human health and food security. These standards will not reduce CO2 emissions, however, which is required to mitigate long-term climate change.

Effects of climate on emerald ash borer mortality and the potential for ash survival in North America

Treesearch

Ryan D. DeSantis; W. Keith Moser; Dale D. Gormanson; Marshall G. Bartlett; Bradley Vermunt

2013-01-01

Non-native invasive insects such as the emerald ash borer (Agrilus planipennis Fairmaire; EAB) cause billions of dollars; worth of economic damage and unquantifiable but substantial ecological damage in North America each year. There are methods to mitigate, contain, control, or even eradicate some non-native invasive insects, but so far the spread...

Fabrication of mitigation pits for improving laser damage resistance in dielectric mirrors by femtosecond laser machining

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolfe, Justin E.; Qiu, S. Roger; Stolz, Christopher J.

2011-03-20

Femtosecond laser machining is used to create mitigation pits to stabilize nanosecond laser-induced damage in multilayer dielectric mirror coatings on BK7 substrates. In this paper, we characterize features and the artifacts associated with mitigation pits and further investigate the impact of pulse energy and pulse duration on pit quality and damage resistance. Our results show that these mitigation features can double the fluence-handling capability of large-aperture optical multilayer mirror coatings and further demonstrate that femtosecond laser macromachining is a promising means for fabricating mitigation geometry in multilayer coatings to increase mirror performance under high-power laser irradiation.

Integration of biological control and transgenic insect protection for mitigation of mycotoxins in corn

USDA-ARS?s Scientific Manuscript database

Biological control is known to be effective in reducing aflatoxin contamination of corn and some transgenic corn hybrids incur greatly reduced damage from corn earworm (Helicoverpa zea). We conducted seven field trials over two years to test the hypothesis that transgenic insect protection and biol...

Spot-shadowing optimization to mitigate damage growth in a high-energy-laser amplifier chain.

PubMed

Bahk, Seung-Whan; Zuegel, Jonathan D; Fienup, James R; Widmayer, C Clay; Heebner, John

2008-12-10

A spot-shadowing technique to mitigate damage growth in a high-energy laser is studied. Its goal is to minimize the energy loss and undesirable hot spots in intermediate planes of the laser. A nonlinear optimization algorithm solves for the complex fields required to mitigate damage growth in the National Ignition Facility amplifier chain. The method is generally applicable to any large fusion laser.

Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin.

PubMed

Jelveh, Salomeh; Kaspler, Pavel; Bhogal, Nirmal; Mahmood, Javed; Lindsay, Patricia E; Okunieff, Paul; Doctrow, Susan R; Bristow, Robert G; Hill, Richard P

2013-08-01

Radioprotection and mitigation effects of the antioxidants, Eukarion (EUK)-207, curcumin, and the curcumin analogs D12 and D68, on radiation-induced DNA damage or lipid peroxidation in murine skin were investigated. These antioxidants were studied because they have been previously reported to protect or mitigate against radiation-induced skin reactions. DNA damage was assessed using two different assays. A cytokinesis-blocked micronucleus (MN) assay was performed on primary skin fibroblasts harvested from the skin of C3H/HeJ male mice 1 day, 1 week and 4 weeks after 5 Gy or 10 Gy irradiation. Local skin or whole body irradiation (100 kVp X-rays or caesium (Cs)-137 γ-rays respectively) was performed. DNA damage was further quantified in keratinocytes by immunofluorescence staining of γ-histone 2AX (γ-H2AX) foci in formalin-fixed skin harvested 1 hour or 1 day post-whole body irradiation. Radiation-induced lipid peroxidation in the skin was investigated at the same time points as the MN assay by measuring malondialdehyde (MDA) with a Thiobarbituric acid reactive substances (TBARS) assay. None of the studied antioxidants showed significant mitigation of skin DNA damage induced by local irradiation. However, when EUK-207 or curcumin were delivered before irradiation they provided some protection against DNA damage. In contrast, all the studied antioxidants demonstrated significant mitigating and protecting effects on radiation-induced lipid peroxidation at one or more of the three time points after local skin irradiation. Our results show no evidence for mitigation of DNA damage by the antioxidants studied in contrast to mitigation of lipid peroxidation. Since these agents have been reported to mitigate skin reactions following irradiation, the data suggest that changes in lipid peroxidation levels in skin may reflect developing skin reactions better than residual post-irradiation DNA damage in skin cells. Further direct comparison studies are required to confirm this inference from the data.

Aligned composite structures for mitigation of impact damage and resistance to wear in dynamic environments

DOEpatents

Mulligan, Anthony C.; Rigali, Mark J.; Sutaria, Manish P.; Popovich, Dragan; Halloran, Joseph P.; Fulcher, Michael L.; Cook, Randy C.

2005-12-13

Fibrous monolith composites having architectures that provide increased flaw insensitivity, improved hardness, wear resistance and damage tolerance and methods of manufacture thereof are provided for use in dynamic environments to mitigate impact damage and increase wear resistance.

Aligned composite structures for mitigation of impact damage and resistance to wear in dynamic environments

DOEpatents

Mulligan, Anthony C.; Rigali, Mark J.; Sutaria, Manish P.; Popovich, Dragan; Halloran, Joseph P.; Fulcher, Michael L.; Cook, Randy C.

2009-04-14

Fibrous monolith composites having architectures that provide increased flaw insensitivity, improved hardness, wear resistance and damage tolerance and methods of manufacture thereof are provided for use in dynamic environments to mitigate impact damage and increase wear resistance.

Aligned composite structures for mitigation of impact damage and resistance to wear in dynamic environments

DOEpatents

Rigali, Mark J.; Sutaria, Manish P.; Mulligan, Anthony C.; Popovich, Dragan

2004-03-23

Fibrous monolith composites having architectures that provide increased flaw insensitivity, improved hardness, wear resistance and damage tolerance and methods of manufacture thereof are provided for use in dynamic environments to mitigate impact damage and increase wear resistance.

Discussion

NASA Astrophysics Data System (ADS)

Marshall, Tim

Presenter, Jim McDonald, Texas Tech University [McDonald, this volume, Damage mitigation and occupant safety]. (Arnold Court, California State University.) Can you tell me how to park my car to mitigate tornado damage?

Flight Test Approach to Adaptive Control Research

NASA Technical Reports Server (NTRS)

Pavlock, Kate Maureen; Less, James L.; Larson, David Nils

2011-01-01

The National Aeronautics and Space Administration s Dryden Flight Research Center completed flight testing of adaptive controls research on a full-scale F-18 testbed. The validation of adaptive controls has the potential to enhance safety in the presence of adverse conditions such as structural damage or control surface failures. This paper describes the research interface architecture, risk mitigations, flight test approach and lessons learned of adaptive controls research.

Fuel Flexibility: Landfill Gas Contaminant Mitigation for Power Generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Storey, John Morse; Theiss, Timothy J; Kass, Michael D

This research project focused on the mitigation of silica damage to engine-based renewable landfill gas energy systems. Characterization of the landfill gas siloxane contamination, combined with characterization of the silica deposits in engines, led to development of two new mitigation strategies. The first involved a novel method for removing the siloxanes and other heavy contaminants from the landfill gas prior to use by the engines. The second strategy sought to interrupt the formation of hard silica deposits in the engine itself, based on inspection of failed landfill gas engine parts. In addition to mitigation, the project had a third taskmore » to develop a robust sensor for siloxanes that could be used to control existing and/or future removal processes.« less

Damage Characterization Method for Structural Health Management Using Reduced Number of Sensor Inputs

NASA Technical Reports Server (NTRS)

Krishnamurthy, T.; Hochhalter, Jacob D.; Gallegos, Adam M.

2012-01-01

The development of validated multidisciplinary Integrated Vehicle Health Management (IVHM) tools, technologies, and techniques to enable detection, diagnosis, prognosis, and mitigation in the presence of adverse conditions during flight will provide effective solutions to deal with safety related challenges facing next generation aircraft. The adverse conditions include loss of control caused by environmental factors, actuator and sensor faults or failures, and damage conditions. A major concern in these structures is the growth of undetected damage (cracks) due to fatigue and low velocity foreign impacts that can reach a critical size during flight, resulting in loss of control of the aircraft. Hence, development of efficient methodologies to determine the presence, location, and severity of damage in critical structural components is highly important in developing efficient structural health management systems.

Damage Characterization Using the Extended Finite Element Method for Structural Health Management

NASA Technical Reports Server (NTRS)

Krishnamurthy, Thiagarajan; Gallegos, Adam M.

2011-01-01

The development of validated multidisciplinary Integrated Vehicle Health Management (IVHM) tools, technologies, and techniques to enable detection, diagnosis, prognosis, and mitigation in the presence of adverse conditions during flight will provide effective solutions to deal with safety related challenges facing next generation aircraft. The adverse conditions include loss of control caused by environmental factors, actuator and sensor faults or failures, and damage conditions. A major concern in these structures is the growth of undetected damage/cracks due to fatigue and low velocity foreign impact that can reach a critical size during flight, resulting in loss of control of the aircraft. Hence, development of efficient methodologies to determine the presence, location, and severity of damage/cracks in critical structural components is highly important in developing efficient structural health management systems.

Method for producing damage resistant optics

DOEpatents

Hackel, Lloyd A.; Burnham, Alan K.; Penetrante, Bernardino M.; Brusasco, Raymond M.; Wegner, Paul J.; Hrubesh, Lawrence W.; Kozlowski, Mark R.; Feit, Michael D.

2003-01-01

The present invention provides a system that mitigates the growth of surface damage in an optic. Damage to the optic is minimally initiated. In an embodiment of the invention, damage sites in the optic are initiated, located, and then treated to stop the growth of the damage sites. The step of initiating damage sites in the optic includes a scan of the optic using a laser to initiate defects. The exact positions of the initiated sites are identified. A mitigation process is performed that locally or globally removes the cause of subsequent growth of the damaged sites.

Mitigation of laser damage on National Ignition Facility optics in volume production

NASA Astrophysics Data System (ADS)

Folta, James; Nostrand, Mike; Honig, John; Wong, Nan; Ravizza, Frank; Geraghty, Paul; Taranowski, Mike; Johnson, Gary; Larkin, Glenn; Ravizza, Doug; Peterson, John; Welday, Brian; Wegner, Paul

2013-12-01

The National Ignition Facility has recently achieved the milestone of delivering over 1.8 MJ and 500 TW of 351 nm laser energy and power on target, which required average fluences up to 9 J/cm2 (3 ns equivalent) in the final optics system. Commercial fused silica laser-grade UV optics typically have a maximum operating threshold of 5 J/cm2. We have developed an optics recycling process which enables NIF to operate above the laser damage initiation and growth thresholds. We previously reported a method to mitigate laser damage with laser ablation of the damage site to leave benign cone shaped pits. We have since developed a production facility with four mitigation systems capable of performing the mitigation protocols on full-sized (430 mm) optics in volume production. We have successfully repaired over 700 NIF optics (unique serial numbers), some of which have been recycled as many as 11 times. We describe the mitigation systems, the optics recycle loop process, and optics recycle production data.

Hazard Mitigation Assistance Programs Available to Water and Wastewater Utilities

EPA Pesticide Factsheets

You can prevent damage to your utility before it occurs. Utilities can implement mitigation projects to better withstand a natural disaster, minimize damage and rapidly recover from disruptions to service.

TRADING ALLOWANCES FOR STORMWATER CONTROL: HYDROLOGY AND OPPORTUNITY COSTS

EPA Science Inventory

Excess stormwater runoff is a serious problem in a large number of urban areas, causing flooding, water pollution, groundwater recharge deficits and ecological damage to urban streams. It has been posited that to mitigate the effects of excess stormwater runoff, policy makers...

Bayou Corne Sinkhole: Control Measurements of State Highway 70 in Assumption Parish, Louisiana : Research Project Capsule

DOT National Transportation Integrated Search

2012-09-01

The sinkhole located in northern Assumption Parish, Louisiana, threatens : the stability of Highway 70, a state-maintained route. In order to monitor : and mitigate potential damage eff ects on this infrastructure, the Louisiana : Department of Trans...

Bayou Corne sinkhole : control measurements of State Highway 70 in Assumption Parish, Louisiana, tech summary.

DOT National Transportation Integrated Search

2014-01-01

The sinkhole located in Assumption Parish, Louisiana, threatens the stability of Highway 70, a state maintained route. In order to : mitigate the potential damaging e ects of the sinkhole on this infrastructure, the Louisiana Department of Transpo...

TRADING ALLOWANCES FOR STORMWATER CONTROL: HYDROLOGY AND OPPORTUNITY COSTS

EPA Science Inventory

Excess stormwater runoff is a serious problem in a large number of urban areas, causing flooding, water pollution, groundwater recharge deficits and ecological damage to urban streams. It has been posited that to mitigate the effects of excess stormwater runoff, policy makers cou...

Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa.

PubMed

Strayer, David R; Carter, William A; Stouch, Bruce C; Stittelaar, Koert J; Thoolen, Robert J M M; Osterhaus, Albert D M E; Mitchell, William M

2014-10-01

Using an established nonhuman primate model for H5N1 highly pathogenic influenza virus infection in humans, we have been able to demonstrate the prophylactic mitigation of the pulmonary damage characteristic of human fatal cases from primary influenza virus pneumonia with a low dose oral formulation of a commercially available parenteral natural human interferon alpha (Alferon N Injection®). At the highest oral dose (62.5IU/kg body weight) used there was a marked reduction in the alveolar inflammatory response with minor evidence of alveolar and interstitial edema in contrast to the hemorrhage and inflammatory response observed in the alveoli of control animals. The mitigation of severe damage to the lower pulmonary airway was observed without a parallel reduction in viral titers. Clinical trial data will be necessary to establish its prophylactic human efficacy for highly pathogenic influenza viruses. Copyright © 2014. Published by Elsevier B.V.

Climate change mitigation: comparative assessment of Malaysian and ASEAN scenarios.

PubMed

Rasiah, Rajah; Ahmed, Adeel; Al-Amin, Abul Quasem; Chenayah, Santha

2017-01-01

This paper analyses empirically the optimal climate change mitigation policy of Malaysia with the business as usual scenario of ASEAN to compare their environmental and economic consequences over the period 2010-2110. A downscaling empirical dynamic model is constructed using a dual multidisciplinary framework combining economic, earth science, and ecological variables to analyse the long-run consequences. The model takes account of climatic variables, including carbon cycle, carbon emission, climatic damage, carbon control, carbon concentration, and temperature. The results indicate that without optimal climate policy and action, the cumulative cost of climate damage for Malaysia and ASEAN as a whole over the period 2010-2110 would be MYR40.1 trillion and MYR151.0 trillion, respectively. Under the optimal policy, the cumulative cost of climatic damage for Malaysia would fall to MYR5.3 trillion over the 100 years. Also, the additional economic output of Malaysia will rise from MYR2.1 billion in 2010 to MYR3.6 billion in 2050 and MYR5.5 billion in 2110 under the optimal climate change mitigation scenario. The additional economic output for ASEAN would fall from MYR8.1 billion in 2010 to MYR3.2 billion in 2050 before rising again slightly to MYR4.7 billion in 2110 in the business as usual ASEAN scenario.

Evaluation of long carbon fiber reinforced concrete to mitigate earthquake damage of infrastructure components.

DOT National Transportation Integrated Search

2013-06-01

The proposed study involves investigating long carbon fiber reinforced concrete as a method of mitigating earthquake damage to : bridges and other infrastructure components. Long carbon fiber reinforced concrete has demonstrated significant resistanc...

Nonlinear Control of a Reusable Rocket Engine for Life Extension

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Holmes, Michael S.; Ray, Asok

1998-01-01

This paper presents the conceptual development of a life-extending control system where the objective is to achieve high performance and structural durability of the plant. A life-extending controller is designed for a reusable rocket engine via damage mitigation in both the fuel (H2) and oxidizer (O2) turbines while achieving high performance for transient responses of the combustion chamber pressure and the O2/H2 mixture ratio. The design procedure makes use of a combination of linear and nonlinear controller synthesis techniques and also allows adaptation of the life-extending controller module to augment a conventional performance controller of the rocket engine. The nonlinear aspect of the design is achieved using non-linear parameter optimization of a prescribed control structure. Fatigue damage in fuel and oxidizer turbine blades is primarily caused by stress cycling during start-up, shutdown, and transient operations of a rocket engine. Fatigue damage in the turbine blades is one of the most serious causes for engine failure.

A Topical Mitochondria-Targeted Redox Cycling Nitroxide Mitigates Oxidative Stress Induced Skin Damage

PubMed Central

Brand, Rhonda M.; Epperly, Michael W.; Stottlemyer, J. Mark; Skoda, Erin M.; Gao, Xiang; Li, Song; Huq, Saiful; Wipf, Peter; Kagan, Valerian E.; Greenberger, Joel S.; Falo, Louis D.

2017-01-01

Skin is the largest human organ and provides a first line of defense that includes physical, chemical, and immune mechanisms to combat environmental stress. Radiation is a prevalent environmental stressor. Radiation induced skin damage ranges from photoaging and cutaneous carcinogenesis from UV exposure, to treatment-limiting radiation dermatitis associated with radiotherapy, to cutaneous radiation syndrome, a frequently fatal consequence of exposures from nuclear accidents. The major mechanism of skin injury common to these exposures is radiation induced oxidative stress. Efforts to prevent or mitigate radiation damage have included development of antioxidants capable of reducing reactive oxygen species (ROS). Mitochondria are particularly susceptible to oxidative stress, and mitochondrial dependent apoptosis plays a major role in radiation induced tissue damage. We reasoned that targeting a redox cycling nitroxide to mitochondria could prevent ROS accumulation, limiting downstream oxidative damage and preserving mitochondrial function. Here we show that in both mouse and human skin, topical application of a mitochondrial targeted antioxidant prevents and mitigates radiation induced skin damage characterized by clinical dermatitis, loss of barrier function, inflammation, and fibrosis. Further, damage mitigation is associated with reduced apoptosis, preservation of the skin’s antioxidant capacity, and reduction of irreversible DNA and protein oxidation associated with oxidative stress. PMID:27794421

TRADING ALLOWANCES FOR STORMWATER CONTROL: ACCOUNTING FOR CONTINUOUS HYDROLOGY AND OPPORTUNITY COSTS

EPA Science Inventory

Excess stormwater runoff is a serious problem in a large number of urban areas, causing flooding, water pollution, groundwater recharge deficits and ecological damage to urban streams. It has been posited that to mitigate the effects of excess stormwater runoff, policy makers cou...

Rainfall-triggered landslides, anthropogenic hazards, and mitigation strategies

USGS Publications Warehouse

Larsen, M.C.

2008-01-01

Rainfall-triggered landslides are part of a natural process of hillslope erosion that can result in catastrophic loss of life and extensive property damage in mountainous, densely populated areas. As global population expansion on or near steep hillslopes continues, the human and economic costs associated with landslides will increase. Landslide hazard mitigation strategies generally involve hazard assessment mapping, warning systems, control structures, and regional landslide planning and policy development. To be sustainable, hazard mitigation requires that management of natural resources is closely connected to local economic and social interests. A successful strategy is dependent on a combination of multi-disciplinary scientific and engineering approaches, and the political will to take action at the local community to national scale.

Prediction and mitigation of scour and scour damage to Vermont bridges.

DOT National Transportation Integrated Search

2017-02-20

Over 300 Vermont bridges were damaged in the 2011 Tropical Storm Irene and many experienced significant scour. Successfully mitigating bridge scour in future flooding events depends on our ability to reliably estimate scour potential, design safe and...

Robust Rocket Engine Concept

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.

1995-01-01

The potential for a revolutionary step in the durability of reusable rocket engines is made possible by the combination of several emerging technologies. The recent creation and analytical demonstration of life extending (or damage mitigating) control technology enables rapid rocket engine transients with minimum fatigue and creep damage. This technology has been further enhanced by the formulation of very simple but conservative continuum damage models. These new ideas when combined with recent advances in multidisciplinary optimization provide the potential for a large (revolutionary) step in reusable rocket engine durability. This concept has been named the robust rocket engine concept (RREC) and is the basic contribution of this paper. The concept also includes consideration of design innovations to minimize critical point damage.

Emerald ash borer modeling methods for future forest projections

Treesearch

Ryan D. Desantis; W. Keith Moser; Robert J. Jr. Hugett; Ruhong Li; David N. Wear; Patrick D. Miles

2012-01-01

The emerald ash borer (Agrilus planipennis Fairmaire; EAB) is a nonnative invasive insect that has caused considerable damage to ash (Fraxinus spp.) in North America. Unlike invasive organisms that can be mitigated, contained, controlled, or even eradicated, EAB continues to spread across North America. The loss of the North...

Predicting, examining, and evaluating FAC in US power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohn, M.J.; Garud, Y.S.; Raad, J. de

1999-11-01

There have been many pipe failures in fossil and nuclear power plant piping systems caused by flow-accelerated corrosion (FAC). In some piping systems, this failure mechanism maybe the most important type of damage to mitigate because FAC damage has led to catastrophic failures and fatalities. Detecting the damage and mitigating the problem can significantly reduce future forced outages and increase personnel safety. This article discusses the implementation of recent developments to select FAC inspection locations, perform cost-effective examinations, evaluate results, and mitigate FAC failures. These advances include implementing the combination of software to assist in selecting examination locations and anmore » improved pulsed eddy current technique to scan for wall thinning without removing insulation. The use of statistical evaluation methodology and possible mitigation strategies also are discussed.« less

Flight Approach to Adaptive Control Research

NASA Technical Reports Server (NTRS)

Pavlock, Kate Maureen; Less, James L.; Larson, David Nils

2011-01-01

The National Aeronautics and Space Administration's Dryden Flight Research Center completed flight testing of adaptive controls research on a full-scale F-18 testbed. The testbed served as a full-scale vehicle to test and validate adaptive flight control research addressing technical challenges involved with reducing risk to enable safe flight in the presence of adverse conditions such as structural damage or control surface failures. This paper describes the research interface architecture, risk mitigations, flight test approach and lessons learned of adaptive controls research.

Neurosurgical patties: adhesion and damage mitigation.

PubMed

Stratton-Powell, Ashley A; Anderson, Ian A; Timothy, Jake; Kapur, Nikil; Culmer, Peter

2015-07-01

Neurosurgical patties are textile pads used during most neurosurgical operations to protect tissues, manage the fluid environment, control hemostasis, and aid tissue manipulation. Recent research has suggested that, contrary to their aim, patties adhere to brain tissue and cause damage during removal. This study aimed to characterize and quantify the degree of and consequences resulting from adhesion between neurosurgical patties and brain tissue. Using a customized peel apparatus, the authors performed 90° peel tests on 5 patty products: Policot, Telfa, Americot, Delicot, and Ray-Cot (n = 247) from American Surgical Company. They tested 4 conditions: wet patty on glass (control), wet patty on wet brain peeled at 5 mm/sec (wet), dry patty on wet brain peeled at 5 mm/sec (dry), and wet patty on wet brain peeled at 20 mm/sec (speed). The interaction between patty and tissue was analyzed using peel-force traces and pre-peel histological analysis. Adhesion strength differed between patty products (p < 0.001) and conditions (p < 0.001). Adhesion strength was greatest for Delicot patties under wet (2.22 mN/mm) and dry (9.88 mN/mm) conditions. For all patties, damage at the patty-tissue interface was proportional to the degree of fiber contact. When patties were irrigated, mechanical adhesion was reduced by up to 550% compared with dry usage. For all patty products, mechanical (destructive) and liquid-mediated (nondestructive) adhesion caused damage to neural tissue. The greatest adhesion occurred with Delicot patties. To mitigate patty adhesion and neural tissue damage, surgeons should consider regular irrigation to be essential during neurosurgical procedures.

Seismic rehabilitation of skewed and curved bridges using a new generation of buckling restrained braces : research brief.

DOT National Transportation Integrated Search

2016-12-01

Damage to skewed and curved bridges during strong earthquakes is documented. This project investigates whether such damage could be mitigated by using buckling restrained braces. Nonlinear models show that using buckling restrained braces to mitigate...

Next generation control system for reflexive aerostructures

NASA Astrophysics Data System (ADS)

Maddux, Michael R.; Meents, Elizabeth P.; Barnell, Thomas J.; Cable, Kristin M.; Hemmelgarn, Christopher; Margraf, Thomas W.; Havens, Ernie

2010-04-01

Cornerstone Research Group Inc. (CRG) has developed and demonstrated a composite structural solution called reflexive composites for aerospace applications featuring CRG's healable shape memory polymer (SMP) matrix. In reflexive composites, an integrated structural health monitoring (SHM) system autonomously monitors the structural health of composite aerospace structures, while integrated intelligent controls monitor data from the SHM system to characterize damage and initiate healing when damage is detected. Development of next generation intelligent controls for reflexive composites were initiated for the purpose of integrating prognostic health monitoring capabilities into the reflexive composite structural solution. Initial efforts involved data generation through physical inspections and mechanical testing. Compression after impact (CAI) testing was conducted on composite-reinforced shape memory polymer samples to induce damage and investigate the effectiveness of matrix healing on mechanical performance. Non-destructive evaluation (NDE) techniques were employed to observe and characterize material damage. Restoration of mechanical performance was demonstrated through healing, while NDE data showed location and size of damage and verified mitigation of damage post-healing. Data generated was used in the development of next generation reflexive controls software. Data output from the intelligent controls could serve as input to Integrated Vehicle Health Management (IVHM) systems and Integrated Resilient Aircraft Controls (IRAC). Reflexive composite technology has the ability to reduce maintenance required on composite structures through healing, offering potential to significantly extend service life of aerospace vehicles and reduce operating and lifecycle costs.

Assessing Hurricane Katrina Vegetation Damage at Stennis Space Center using IKONOS Image Classification Techniques

NASA Technical Reports Server (NTRS)

Spruce, Joseph P.; Ross, Kenton W.; Graham, William D.

2007-01-01

Hurricane Katrina hit southwestern Mississippi on August 29, 2005, at 9:45 a.m. CDT as a category 3 storm with surges up to approx. 9 m and sustained winds of approx. 120 mph. The hurricane's wind, rain, and flooding devastated several coastal towns, from New Orleans through Mobile. The storm also caused significant damage to infrastructure and vegetation of NASA's SSC (Stennis Space Center). Storm recovery at SSC involved not only repairs of critical infrastructure but also forest damage mitigation (via timber harvests and control burns to reduce fire risk). This presentation discusses an effort to use commercially available high spatial resolution multispectral IKONOS data for vegetation damage assessment, based on data collected over SSC on September 2, 2005.

Biological control as a tool to mitigate economic impacts of facilitative ecological interactions between the giant reed and cattle fever ticks

USDA-ARS?s Scientific Manuscript database

Annual domestic impacts associated with introduced weeds are conservatively estimated at $27 billion, incorporating costs of weed management, crop losses and displacement of productive rangeland, and displacement of some environmental services. Estimating the total economic damage of invasive weed...

Optimal CO2 mitigation under damage risk valuation

NASA Astrophysics Data System (ADS)

Crost, Benjamin; Traeger, Christian P.

2014-07-01

The current generation has to set mitigation policy under uncertainty about the economic consequences of climate change. This uncertainty governs both the level of damages for a given level of warming, and the steepness of the increase in damage per warming degree. Our model of climate and the economy is a stochastic version of a model employed in assessing the US Social Cost of Carbon (DICE). We compute the optimal carbon taxes and CO2 abatement levels that maximize welfare from economic consumption over time under different risk states. In accordance with recent developments in finance, we separate preferences about time and risk to improve the model's calibration of welfare to observed market interest. We show that introducing the modern asset pricing framework doubles optimal abatement and carbon taxation. Uncertainty over the level of damages at a given temperature increase can result in a slight increase of optimal emissions as compared to using expected damages. In contrast, uncertainty governing the steepness of the damage increase in temperature results in a substantially higher level of optimal mitigation.

Identifying the impact of the built environment on flood damage in Texas.

PubMed

Brody, Samuel D; Zahran, Sammy; Highfield, Wesley E; Grover, Himanshu; Vedlitz, Arnold

2008-03-01

Floods continue to pose the greatest threat to the property and safety of human communities among all natural hazards in the United States. This study examines the relationship between the built environment and flood impacts in Texas, which consistently sustains the most damage from flooding of any other state in the country. Specifically, we calculate property damage resulting from 423 flood events between 1997 and 2001 at the county level. We identify the effect of several built environment measures, including wetland alteration, impervious surface, and dams on reported property damage while controlling for biophysical and socio-economic characteristics. Statistical results suggest that naturally occurring wetlands play a particularly important role in mitigating flood damage. These findings provide guidance to planners and flood managers on how to alleviate most effectively the costly impacts of foods at the community level.

Modeling the effects of emerald ash borer on forest composition in the Midwest and Northeast United States

Treesearch

Ryan D. DeSantis; W. Keith Moser; Robert J. Huggett; Ruhong Li; David N. Wear; Patrick D. Miles

2013-01-01

The nonnative invasive emerald ash borer (Agrilus planipennis Fairmaire; EAB) has caused considerable damage to the ash (Fraxinus spp.) resource in North America. While there are methods to mitigate, contain, control, or even eradicate some nonnative invasive insects, EAB continues to spread across North America. Considering strong...

High-fidelity Modeling of Local Effects of Damage for Derated Offshore Wind Turbines

NASA Astrophysics Data System (ADS)

Richards, Phillip W.; Griffith, D. Todd; Hodges, Dewey H.

2014-06-01

Offshore wind power production is an attractive clean energy option, but the difficulty of access can lead to expensive and rare opportunities for maintenance. As part of the Structural Health and Prognostics Management (SHPM) project at Sandia National Laboratories, smart loads management (controls) are investigated for their potential to increase the fatigue life of offshore wind turbine rotor blades. Derating refers to altering the rotor angular speed and blade pitch to limit power production and loads on the rotor blades. High- fidelity analysis techniques like 3D finite element modeling (FEM) should be used alongside beam models of wind turbine blades to characterize these control strategies in terms of their effect to mitigate fatigue damage and extend life of turbine blades. This study will consider a commonly encountered damage type for wind turbine blades, the trailing edge disbond, and show how FEM can be used to quantify the effect of operations and control strategies designed to extend the fatigue life of damaged blades. The Virtual Crack Closure Technique (VCCT) will be used to post-process the displacement and stress results to provide estimates of damage severity/criticality and provide a means to estimate the fatigue life under a given operations and control strategy.

Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.

PubMed

Pagliassotti, Michael J; Estrada, Andrea L; Hudson, William M; Wei, Yuren; Wang, Dong; Seals, Douglas R; Zigler, Melanie L; LaRocca, Thomas J

2017-07-01

The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging and cellular damage. Quality control systems, such as the unfolded protein response (UPR), inflammatory signaling and protein degradation, mitigate the residence time of damaged proteins. In the present study, we have examined the UPR and inflammatory signaling in the liver of young (~6 months) and old (~28 months) mice (n=8/group), and the ability of trehalose, a compound linked to increased protein stability and autophagy, to counteract age-induced effects on these systems. When used, trehalose was provided for 4 weeks in the drinking water immediately prior to sacrifice (n=7/group). Livers from old mice were characterized by activation of the UPR, increased inflammatory signaling and indices of liver injury. Trehalose treatment reduced the activation of the UPR and inflammatory signaling, and reduced liver injury. Reductions in proteins involved in autophagy and proteasome activity observed in old mice were restored following trehalose treatment. The autophagy marker, LC3B-II, was increased in old mice treated with trehalose. Metabolomics analyses demonstrated that reductions in hexosamine biosynthetic pathway metabolites and nicotinamide in old mice were restored following trehalose treatment. Trehalose appears to be an effective intervention to reduce age-associated liver injury and mitigate the need for activation of quality control systems that respond to disruption of proteostasis. Copyright © 2017 Elsevier Inc. All rights reserved.

TGF-.beta. antagonists as mitigators of radiation-induced tissue damage

DOEpatents

Barcellos-Hoff, Mary H.

1997-01-01

A method for treating tissue damage caused by radiation is described by use of a TGF-.beta. antagonist, such as an anti-TGF-.beta. antibody or a TGF-.beta. latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

TGF-{beta} antagonists as mitigators of radiation-induced tissue damage

DOEpatents

Barcellos-Hoff, M.H.

1997-04-01

A method for treating tissue damage caused by radiation is described by use of a TGF-{beta} antagonist, such as an anti-TGF-{beta} antibody or a TGF-{beta} latency associated protein. It is administered not more than a week after exposure, and is particularly useful in mitigating the side effects of breast cancer therapy.

Particle damage sources for fused silica optics and their mitigation on high energy laser systems.

PubMed

Bude, J; Carr, C W; Miller, P E; Parham, T; Whitman, P; Monticelli, M; Raman, R; Cross, D; Welday, B; Ravizza, F; Suratwala, T; Davis, J; Fischer, M; Hawley, R; Lee, H; Matthews, M; Norton, M; Nostrand, M; VanBlarcom, D; Sommer, S

2017-05-15

High energy laser systems are ultimately limited by laser-induced damage to their critical components. This is especially true of damage to critical fused silica optics, which grows rapidly upon exposure to additional laser pulses. Much progress has been made in eliminating damage precursors in as-processed fused silica optics (the advanced mitigation process, AMP3), and very high damage resistance has been demonstrated in laboratory studies. However, the full potential of these improvements has not yet been realized in actual laser systems. In this work, we explore the importance of additional damage sources-in particular, particle contamination-for fused silica optics fielded in a high-performance laser environment, the National Ignition Facility (NIF) laser system. We demonstrate that the most dangerous sources of particle contamination in a system-level environment are laser-driven particle sources. In the specific case of the NIF laser, we have identified the two important particle sources which account for nearly all the damage observed on AMP3 optics during full laser operation and present mitigations for these particle sources. Finally, with the elimination of these laser-driven particle sources, we demonstrate essentially damage free operation of AMP3 fused silica for ten large optics (a total of 12,000 cm 2 of beam area) for shots from 8.6 J/cm 2 to 9.5 J/cm 2 of 351 nm light (3 ns Gaussian pulse shapes). Potentially many other pulsed high energy laser systems have similar particle sources, and given the insight provided by this study, their identification and elimination should be possible. The mitigations demonstrated here are currently being employed for all large UV silica optics on the National Ignition Facility.

Doxycycline Attenuates Lipopolysaccharide-Induced Microvascular Endothelial Cell Derangements.

PubMed

Wiggins-Dohlvik, Katie; Stagg, Hayden W; Han, Min Suk; Alluri, Himakarnika; Oakley, Ryan P; Anasooya Shaji, Chinchusha; Davis, Matthew L; Tharakan, Binu

2016-06-01

Lipopolysaccharide (LPS) is known to induce vascular derangements. The pathophysiology involved therein is unknown, but matrix metalloproteinases (MMPs) may be an important mediator. We hypothesized that in vitro LPS provokes vascular permeability, damages endothelial structural proteins, and increases MMP activity; that in vivo LPS increases permeability and fluid requirements; and that the MMP inhibitor doxycycline mitigates such changes. Rat lung microvascular endothelial cells were divided into four groups: control, LPS, LPS plus doxycycline, and doxycycline. Permeability, structural proteins β-catenin and Filamentous-actin, and MMP-9 activity were examined. Sprauge Dawley rats were divided into sham, IV LPS, and IV LPS plus IV doxycycline groups. Mesenteric postcapillary venules were observed. Blood pressure was measured as animals were resuscitated and fluid requirements were compared. Statistical analysis was conducted using Student's t-test and ANOVA. In vitro LPS increased permeability, damaged adherens junctions, induced actin stress fiber formation, and increased MMP-9 enzyme activity. In vivo, IV LPS administration induced vascular permeability. During resuscitation, significantly more fluid was necessary to maintain normotension in the IV LPS group. Doxycycline mitigated all derangements observed. We conclude that LPS increases permeability, damages structural proteins, and increases MMP-9 activity in endothelial cells. Additionally, endotoxemia induces hyperpermeability and increases the amount of IV fluid required to maintain normotension in vivo. Doxycycline mitigates such changes both in vitro and in vivo. Our findings illuminate the possible role of matrix metalloproteinases in the pathophysiology of lipopolysaccharide-induced microvascular hyperpermeability and pave the way for better understanding and treatment of this process.

Optimization of morphological parameters for mitigation pits on rear KDP surface: experiments and numerical modeling.

PubMed

Yang, Hao; Cheng, Jian; Chen, Mingjun; Wang, Jian; Liu, Zhichao; An, Chenhui; Zheng, Yi; Hu, Kehui; Liu, Qi

2017-07-24

In high power laser systems, precision micro-machining is an effective method to mitigate the laser-induced surface damage growth on potassium dihydrogen phosphate (KDP) crystal. Repaired surfaces with smooth spherical and Gaussian contours can alleviate the light field modulation caused by damage site. To obtain the optimal repairing structure parameters, finite element method (FEM) models for simulating the light intensification caused by the mitigation pits on rear KDP surface were established. The light intensity modulation of these repairing profiles was compared by changing the structure parameters. The results indicate the modulation is mainly caused by the mutual interference between the reflected and incident lights on the rear surface. Owing to the total reflection, the light intensity enhancement factors (LIEFs) of the spherical and Gaussian mitigation pits sharply increase when the width-depth ratios are near 5.28 and 3.88, respectively. To achieve the optimal mitigation effect, the width-depth ratios greater than 5.3 and 4.3 should be applied to the spherical and Gaussian repaired contours. Particularly, for the cases of width-depth ratios greater than 5.3, the spherical repaired contour is preferred to achieve lower light intensification. The laser damage test shows that when the width-depth ratios are larger than 5.3, the spherical repaired contour presents higher laser damage resistance than that of Gaussian repaired contour, which agrees well with the simulation results.

Mitigation of the consequence of seismically induced damage on a utility water network by means of next generation SCADA

NASA Astrophysics Data System (ADS)

Robertson, Jamie; Shinozuka, Masanobu; Wu, Felix

2011-04-01

When a lifeline system such as a water delivery network is damaged due to a severe earthquake, it is critical to identify its location and extent of the damage in real time in order to minimize the potentially disastrous consequence such damage could otherwise entail. This paper demonstrates how the degree of such minimization can be estimated qualitatively by using the water delivery system of Irvine Water Ranch District (IRWD) as testbed, when it is subjected to magnitude 6.6 San Joaquin Hills Earthquake. In this demonstration, we consider two cases when the IRWD system is equipped or not equipped with a next generation SCADA which consists of a network of MEMS acceleration sensors densely populated and optimally located. These sensors are capable of identifying the location and extent of the damage as well as transmitting the data to the SCADA center for monitoring and control.

Evaluation of a portable MOS electronic nose to detect root rots in shade tree species

Treesearch

Manuela Baietto; Letizia Pozzi; Alphus Dan Wilson; Daniele Bassi

2013-01-01

The early detection of wood decays in high-value standing trees is very important in urban areas because mitigating control measures must be implemented long before tree failures result in property damage or injuries to citizens. Adverse urban environments increase physiological stresses in trees, causing greater susceptibility to attacks by pathogenic decay fungi. The...

Gum acacia mitigates genetic damage in adenine-induced chronic renal failure in rats.

PubMed

Ali, B H; Al Balushi, K; Al-Husseini, I; Mandel, P; Nemmar, A; Schupp, N; Ribeiro, D A

2015-12-01

Subjects with chronic renal failure (CRF) exhibit oxidative genome damage, which may predispose to carcinogenesis, and Gum acacia (GumA) ameliorates this condition in humans and animals. We evaluated here renal DNA damage and urinary excretion of four nucleic acid oxidation adducts namely 8-oxoguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), 8-oxoguanosine (8-oxoGuo) and 8-hydroxy-2-deoxyguanisone (8-OHdg) in rats with adenine (ADE)-induced CRF with and without GumA treatment. Twenty-four rats were divided into four equal groups and treated for 4 weeks. The first group was given normal food and water (control). The second group was given normal food and GumA (15% w/v) in drinking water. The third group was fed powder diet containing adenine (ADE) (0·75% w/w in feed). The fourth group was fed like in the third group, plus GumA in drinking water (15%, w/v). ADE feeding induced CRF (as measured by several physiological, biochemical and histological indices) and also caused a significant genetic damage and significant decreases in urinary 8-oxo Gua and 8-oxoGuo, but not in the other nucleic acids. However, concomitant GumA treatment reduced the level of genetic damage in kidney cells as detected by Comet assay and significantly reversed the effect of adenine on urinary 8-oxoGuo. Treatment with GumA is able to mitigate genetic damage in renal tissues of rats with ADE-induced CRF. © 2015 Stichting European Society for Clinical Investigation Journal Foundation.

Modelling farm vulnerability to flooding: A step toward vulnerability mitigation policies appraisal

NASA Astrophysics Data System (ADS)

Brémond, P.; Abrami, G.; Blanc, C.; Grelot, F.

2009-04-01

Recent catastrophic flood events such as Elbe in 2002 or Rhône in 2003 have shown limits of flood management policies relying on dykes protection: worsening of flood impacts downstream, increased damage by dykes rupture. Those events, among others, contributes to radical changes on the philosophy of flood prevention, with the promotion of new orientations for mitigating flood exposition. Two new trends may have a significant impact on rural areas: floodplain restoration and vulnerability mitigation. The Rhône River program, which is an contract of objectives signed between French Government and local collectivites, is highly illustrative of these new trends and their impact on agricultural sector. In this program, it appears that areas to be concerned by floodplain restoration are agricultural ones, because their supposed vulnerability to flood is expected to be less important to urban areas. As a consequence, agricultural sector is particularly concerned by planned actions on mitigation of assets vulnerability, an important part of the program (financial support of European Union of 7.5 Million euros). Mitigation of agricultural assets vulnerability reveals particularly interesting for two following reasons. Firstly, it is a way to maintain agricultural activities in floodplains yet existing, without promoting flood protection. Secondly, in case of floodplain restoration, vulnerability mitigation is a way for local authorities to compensate over-flooding impacts. In practice, local authorities may financially support farmers for implementing measures to mitigate their farm vulnerability. On the Rhône River, an important work has already been done to identify farm vulnerability to flooding, and propose measures to mitigate it. More than 3 000 farms exposed to flood risk have been identified representing 88 690 ha of agricultural areas which is estimated to generate damage between 400 and 800 Million euros depending on the season of occurrence for a catastrophic flood. In the case of farm activities, vulnerability mitigation consists in implementing measures which can be: physical (equipment or electric power system elevation), organizational (emergency or recovery plan) or financial (insurance). These measures aim at decreasing the total damage incurred by farmers in case of flooding. For instance, if equipment is elevated, it will not suffer direct damage such as degradation. As a consequence, equipment will be available to continue production or recovery tasks, thus, avoiding indirect damage such as delays, indebtedness… The effects of these policies on farms, in particular vulnerability mitigation cannot be appraised using current methodologies mainly because they do not consider farm as a whole and focus on direct damage at the land plot scale (loss of yield). Moreover, since vulnerability mitigation policies are quite recent, few examples of implementation exist and no feedback experience can be processed. Meanwhile, decision makers and financial actors require more justification of the efficiency of public fund by economic appraisal of the projects. On the Rhône River, decision makers asked for an economic evaluation of the program of farm vulnerability mitigation they plan to implement. This implies to identify the effects of the measures to mitigate farm vulnerability, and to classify them by comparing their efficacy (avoided damage) and their cost of implementation. In this presentation, we propose and discuss a conceptual model of vulnerability at the farm scale. The modelling, in Unified Modelling Language, enabled to represent the ties between spatial, organizational and temporal dimensions, which are central to understanding of farm vulnerability and resilience to flooding. Through this modelling, we encompass three goals: To improve the comprehension of farm vulnerability and create a framework that allow discussion with experts of different disciplines as well as with local farmers; To identify data which are needed to implement the model and to collect them, specifically using the focus group method; Based on the conceptual model, to program a mathematical model which will be used to simulate damage (direct and indirect) on farm due to flood. This last objective should enable us to appraise policy to mitigate vulnerability which is planned to be implemented on Rhône River at the individual and regional scale. Finally, we discuss the possibility to use the UML modelling to develop a multi-agent system approach which could be interesting to take into account ties between farmers (solidarity, loan of equipment) or systemic effects due to the damage incurred by economic partners (loss of market share). Keywords vulnerability, UML modelling, farming systems, flood, mitigation policy, economic valuation

Scalable process for mitigation of laser-damaged potassium dihydrogen phosphate crystal optic surfaces with removal of damaged antireflective coating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elhadj, S.; Steele, W. A.; VanBlarcom, D. S.

Here, we investigate an approach for the recycling of laser-damaged large-aperture deuterated potassium dihydrogen phosphate (DKDP) crystals used for optical switching (KDP) and for frequency conversion (DKDP) in megajoule-class high-power laser systems. The approach consists of micromachining the surface laser damage sites (mitigation), combined with multiple soaks and ultrasonication steps in a coating solvent to remove, synergistically, both the highly adherent machining debris and the laser-damage-affected antireflection coating. We then identify features of the laser-damage-affected coating, such as the “solvent-persistent” coating and the “burned-in” coating, that are difficult to remove by conventional approaches without damaging the surface. We also providemore » a solution to the erosion problem identified in this work when colloidal coatings are processed during ultrasonication. Finally, we provide a proof of principle of the approach by testing the full process that includes laser damage mitigation of DKDP test parts, coat stripping, reapplication of a new antireflective coat, and a laser damage test demonstrating performance up to at least 12 J/cm 2 at UV wavelengths, which is well above current requirements. Our approach ultimately provides a potential path to a scalable recycling loop for the management of optics in large, high-power laser systems that can reduce cost and extend lifetime of highly valuable and difficult to grow large DKDP crystals.« less

Scalable process for mitigation of laser-damaged potassium dihydrogen phosphate crystal optic surfaces with removal of damaged antireflective coating

DOE PAGES

Elhadj, S.; Steele, W. A.; VanBlarcom, D. S.; ...

2017-03-07

Here, we investigate an approach for the recycling of laser-damaged large-aperture deuterated potassium dihydrogen phosphate (DKDP) crystals used for optical switching (KDP) and for frequency conversion (DKDP) in megajoule-class high-power laser systems. The approach consists of micromachining the surface laser damage sites (mitigation), combined with multiple soaks and ultrasonication steps in a coating solvent to remove, synergistically, both the highly adherent machining debris and the laser-damage-affected antireflection coating. We then identify features of the laser-damage-affected coating, such as the “solvent-persistent” coating and the “burned-in” coating, that are difficult to remove by conventional approaches without damaging the surface. We also providemore » a solution to the erosion problem identified in this work when colloidal coatings are processed during ultrasonication. Finally, we provide a proof of principle of the approach by testing the full process that includes laser damage mitigation of DKDP test parts, coat stripping, reapplication of a new antireflective coat, and a laser damage test demonstrating performance up to at least 12 J/cm 2 at UV wavelengths, which is well above current requirements. Our approach ultimately provides a potential path to a scalable recycling loop for the management of optics in large, high-power laser systems that can reduce cost and extend lifetime of highly valuable and difficult to grow large DKDP crystals.« less

Disaster mitigation science for Earthquakes and Tsunamis -For resilience society against natural disasters-

NASA Astrophysics Data System (ADS)

Kaneda, Y.; Takahashi, N.; Hori, T.; Kawaguchi, K.; Isouchi, C.; Fujisawa, K.

2017-12-01

Destructive natural disasters such as earthquakes and tsunamis have occurred frequently in the world. For instance, 2004 Sumatra Earthquake in Indonesia, 2008 Wenchuan Earthquake in China, 2010 Chile Earthquake and 2011 Tohoku Earthquake in Japan etc., these earthquakes generated very severe damages. For the reduction and mitigation of damages by destructive natural disasters, early detection of natural disasters and speedy and proper evacuations are indispensable. And hardware and software developments/preparations for reduction and mitigation of natural disasters are quite important. In Japan, DONET as the real time monitoring system on the ocean floor is developed and deployed around the Nankai trough seismogenic zone southwestern Japan. So, the early detection of earthquakes and tsunamis around the Nankai trough seismogenic zone will be expected by DONET. The integration of the real time data and advanced simulation researches will lead to reduce damages, however, in the resilience society, the resilience methods will be required after disasters. Actually, methods on restorations and revivals are necessary after natural disasters. We would like to propose natural disaster mitigation science for early detections, evacuations and restorations against destructive natural disasters. This means the resilience society. In natural disaster mitigation science, there are lots of research fields such as natural science, engineering, medical treatment, social science and literature/art etc. Especially, natural science, engineering and medical treatment are fundamental research fields for natural disaster mitigation, but social sciences such as sociology, geography and psychology etc. are very important research fields for restorations after natural disasters. Finally, to realize and progress disaster mitigation science, human resource cultivation is indispensable. We already carried out disaster mitigation science under `new disaster mitigation research project on Mega thrust earthquakes around Nankai/Ryukyu subduction zone', and `SATREPS project of earthquake and tsunami disaster mitigation in the Marmara region and disaster education in Turkey'. Furthermore, we have to progress the natural disaster mitigation science against destructive natural disaster in the near future.

Mitigation of Crack Damage in Metallic Materials

NASA Technical Reports Server (NTRS)

Leser, Patrick E.; Newman, John A.; Smith, Stephen W.; Leser, William P.; Wincheski, Russell A.; Wallace, Terryl A.; Glaessgen, Edward H.; Piascik, Robert S.

2014-01-01

A system designed to mitigate or heal crack damage in metallic materials has been developed where the protected material or component is coated with a low-melting temperature film. After a crack is formed, the material is heated, melting the film which then infiltrates the crack opening through capillary action. Upon solidification, the healing material inhibits further crack damage in two ways. While the crack healing material is intact, it acts like an adhesive that bonds or bridges the crack faces together. After fatigue loading damages, the healing material in the crack mouth inhibits further crack growth by creating artificially-high crack closure levels. Mechanical test data show that this method sucessfully arrests or retards crack growth in laboratory specimens.

Integrated analysis considered mitigation cost, damage cost and adaptation cost in Northeast Asia

NASA Astrophysics Data System (ADS)

Park, J. H.; Lee, D. K.; Kim, H. G.; Sung, S.; Jung, T. Y.

2015-12-01

Various studies show that raising the temperature as well as storms, cold snap, raining and drought caused by climate change. And variety disasters have had a damage to mankind. The world risk report(2012, The Nature Conservancy) and UNU-EHS (the United Nations University Institute for Environment and Human Security) reported that more and more people are exposed to abnormal weather such as floods, drought, earthquakes, typhoons and hurricanes over the world. In particular, the case of Korea, we influenced by various pollutants which are occurred in Northeast Asian countries, China and Japan, due to geographical meteorological characteristics. These contaminants have had a significant impact on air quality with the pollutants generated in Korea. Recently, around the world continued their effort to reduce greenhouse gas and to improve air quality in conjunction with the national or regional development goals priority. China is also working on various efforts in accordance with the international flows to cope with climate change and air pollution. In the future, effect of climate change and air quality in Korea and Northeast Asia will be change greatly according to China's growth and mitigation policies. The purpose of this study is to minimize the damage caused by climate change on the Korean peninsula through an integrated approach taking into account the mitigation and adaptation plan. This study will suggest a climate change strategy at the national level by means of a comprehensive economic analysis of the impacts and mitigation of climate change. In order to quantify the impact and damage cost caused by climate change scenarios in a regional scale, it should be priority variables selected in accordance with impact assessment of climate change. The sectoral impact assessment was carried out on the basis of selected variables and through this, to derive the methodology how to estimate damage cost and adaptation cost. And then, the methodology was applied in Korea. Finally, we build an integrated analysis considered mitigation cost, damage cost, and adaptation cost by climate change

A Role for D1 Dopamine Receptors in Striatal Methamphetamine-Induced Neurotoxicity

PubMed Central

Friend, Danielle M.; Keefe, Kristen A.

2015-01-01

Methamphetamine (METH) exposure results in long-term damage to the dopamine system in both human METH abusers and animal models. One factor that has been heavily implicated in this METH-induced damage to the dopaminergic system is the activation of D1 Dopamine (DA) receptors. However, a significant caveat to the studies investigating the role of the receptor in such toxicity is that genetic and pharmacological manipulations of the D1 DA receptor also mitigate METH-induced hyperthermia. Importantly, METH-induced hyperthermia is tightly associated with the neurotoxicity, such that simply cooling animals during METH exposure protects against the neurotoxicity. Therefore, it is difficult to determine whether D1 DA receptors per se play an important role in METH-induced neurotoxicity or whether the protection observed simply resulted from a mitigation of METH-induced hyperthermia. To answer this important question, the current study infused a D1 DA receptor antagonist into striatum during METH exposure while controlling for METH-induced hyperthermia. Here we found that even when METH-induced hyperthermia is maintained, the coadministration of a D1 DA receptor antagonist protects against METH-induced neurotoxicity, strongly suggesting that D1 DA receptors play an important role in METH-induced neurotoxicity apart from the mitigation of METH-induced hyperthermia. PMID:23994061

A role for D1 dopamine receptors in striatal methamphetamine-induced neurotoxicity.

PubMed

Friend, Danielle M; Keefe, Kristen A

2013-10-25

Methamphetamine (METH) exposure results in long-term damage to the dopamine system in both human METH abusers and animal models. One factor that has been heavily implicated in this METH-induced damage to the dopaminergic system is the activation of D1 dopamine (DA) receptors. However, a significant caveat to the studies investigating the role of the receptor in such toxicity is that genetic and pharmacological manipulations of the D1 DA receptor also mitigate METH-induced hyperthermia. Importantly, METH-induced hyperthermia is tightly associated with the neurotoxicity, such that simply cooling animals during METH exposure protects against the neurotoxicity. Therefore, it is difficult to determine whether D1 DA receptors per se play an important role in METH-induced neurotoxicity or whether the protection observed simply resulted from a mitigation of METH-induced hyperthermia. To answer this important question, the current study infused a D1 DA receptor antagonist into striatum during METH exposure while controlling for METH-induced hyperthermia. Here we found that even when METH-induced hyperthermia is maintained, the coadministration of a D1 DA receptor antagonist protects against METH-induced neurotoxicity, strongly suggesting that D1 DA receptors play an important role in METH-induced neurotoxicity apart from the mitigation of METH-induced hyperthermia. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Neural Networks for Flight Control

NASA Technical Reports Server (NTRS)

Jorgensen, Charles C.

1996-01-01

Neural networks are being developed at NASA Ames Research Center to permit real-time adaptive control of time varying nonlinear systems, enhance the fault-tolerance of mission hardware, and permit online system reconfiguration. In general, the problem of controlling time varying nonlinear systems with unknown structures has not been solved. Adaptive neural control techniques show considerable promise and are being applied to technical challenges including automated docking of spacecraft, dynamic balancing of the space station centrifuge, online reconfiguration of damaged aircraft, and reducing cost of new air and spacecraft designs. Our experiences have shown that neural network algorithms solved certain problems that conventional control methods have been unable to effectively address. These include damage mitigation in nonlinear reconfiguration flight control, early performance estimation of new aircraft designs, compensation for damaged planetary mission hardware by using redundant manipulator capability, and space sensor platform stabilization. This presentation explored these developments in the context of neural network control theory. The discussion began with an overview of why neural control has proven attractive for NASA application domains. The more important issues in control system development were then discussed with references to significant technical advances in the literature. Examples of how these methods have been applied were given, followed by projections of emerging application needs and directions.

The impact of earthquakes on the city of Aigio in Greece. Urban planning as a factor in mitigating seismic damage.

NASA Astrophysics Data System (ADS)

Athanasopoulou, Evanthia; Despoiniadou, Varvara; Dritsos, Stefanos

2008-07-01

This paper examines the effects of the mortal earthquake on the city of Aigio in Greece in 1995, with particular focus on urbanization and planning policies. It is based on interviews with experts and surveys on damage to buildings following this earthquake. The analysis takes into account several factors, such as exact location, land use, construction period and the height of damaged buildings. Furthermore, the relationship between the seismic damage and the postseismic construction development of Aigio is examined and the conclusion is reached that the Greek urban planning system needs to be better organized to prepare for seismic damage. To this end, the paper recommends a five-point discussion agenda for applying local planning to seismic mitigation.

Minimum State Awareness for Resilient Control Systems Under Cyber-Attack

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kisner, Roger; Fugate, David L; McIntyre, Timothy J

2012-01-01

State awareness for a control system is the accurate knowledge of the internal states of the system realization. To maintain stable operation, a controller requires a certain degree of state awareness. By definition, a cyber-attacker decreases the state awareness by modifying or removing the information available to the operator and control system. By doing so, the attacker can directly cause damage to the physical system through the control system, or indirectly by causing the operator to react in a damaging manner to the false information. In a number of recent papers, detection and mitigation strategies have been proposed that assumemore » state awareness. The goal of the attacker to reduce or remove state awareness makes this assumption invalid for most situations. One of the central problems of resilient control is developing methods to retain sufficient state awareness to continue operation during a cyberattack. In this paper, we will define state awareness, discuss the consequences of loss of state awareness, and some potential research directions for maintaining state awareness.« less

As we age: Does slippage of quality control in the immune system lead to collateral damage?

PubMed

Müller, Ludmila; Pawelec, Graham

2015-09-01

The vertebrate adaptive immune system is remarkable for its possession of a very broad range of antigen receptors imbuing the system with exquisite specificity, in addition to the phagocytic and inflammatory cells of the innate system shared with invertebrates. This system requires strict control both at the level of the generation the cells carrying these receptors and at the level of their activation and effector function mediation in order to avoid autoimmunity and mitigate immune pathology. Thus, quality control checkpoints are built into the system at multiple nodes in the response, relying on clonal selection and regulatory networks to maximize pathogen-directed effects and minimize collateral tissue damage. However, these checkpoints are compromised with age, resulting in poorer immune control manifesting as tissue-damaging autoimmune and inflammatory phenomena which can cause widespread systemic disease, paradoxically compounding the problems associated with increased susceptibility to infectious disease and possibly cancer in the elderly. Better understanding the reasons for slippage of immune control will pave the way for developing rational strategies for interventions to maintain appropriate immunity while reducing immunopathology. Copyright © 2015 Elsevier B.V. All rights reserved.

[Role of the orbitofrontal cortex in moral judgment].

PubMed

Mimura, Masaru

2010-11-01

The neural substrates of moral judgments have recently been advocated to consist of widely distributed brain networks including the orbitofrontal cortex (OFC), anterior temporal lobe and superior temporal gyrus. Moral judgments could be regarded as a conflict between the top-down rational/logical processes and the bottom-up irrational/emotional processes. Individuals with OFC damage are usually difficult to inhibit emotionally-driven outrages, thereby demonstrating severe impairment of moral judgments despite their well-preserved moral knowledge. Individuals with OFC damage frequently present with anti-social less moral behaviors. However, clinical observation indicates that some OFC patients may show "hypermoral" tendency in the sense that they are too strict to overlook other person's offense. Two representative cases with OFC damage were reported, both presented with extreme rage against others' offensive behaviors. To further elucidate the "hypermorality" of OFC patients, an experiment was performed in which patients with OFC damage and healthy control participants were asked to determine punishments for other's fictitious crimes that varied in perpetrator responsibility and crime severity. Individuals with OFC damage punished more strictly than healthy controls those persons for mitigating circumstances. The results are consistent with clinical observation of OFC patients' highly rigid and inflexible behaviors against third person's offense.

Using risk-based analysis and geographic information systems to assess flooding problems in an urban watershed in Rhode Island.

PubMed

Hardmeyer, Kent; Spencer, Michael A

2007-04-01

This article provides an overview of the use of risk-based analysis (RBA) in flood damage assessment, and it illustrates the use of Geographic Information Systems (GIS) in identifying flood-prone areas, which can aid in flood-mitigation planning assistance. We use RBA to calculate expected annual flood damages in an urban watershed in the state of Rhode Island, USA. The method accounts for the uncertainty in the three primary relationships used in computing flood damage: (1) the probability that a given flood will produce a given amount of floodwater, (2) the probability that a given amount of floodwater will reach a certain stage or height, and (3) the probability that a certain stage of floodwater will produce a given amount of damage. A greater than 50% increase in expected annual flood damage is estimated for the future if previous development patterns continue and flood-mitigation measures are not taken. GIS is then used to create a map that shows where and how often floods might occur in the future, which can help (1) identify priority areas for flood-mitigation planning assistance and (2) disseminate information to public officials and other decision-makers.

RoboCup-Rescue: an international cooperative research project of robotics and AI for the disaster mitigation problem

NASA Astrophysics Data System (ADS)

Tadokoro, Satoshi; Kitano, Hiroaki; Takahashi, Tomoichi; Noda, Itsuki; Matsubara, Hitoshi; Shinjoh, Atsushi; Koto, Tetsuo; Takeuchi, Ikuo; Takahashi, Hironao; Matsuno, Fumitoshi; Hatayama, Mitsunori; Nobe, Jun; Shimada, Susumu

2000-07-01

This paper introduces the RoboCup-Rescue Simulation Project, a contribution to the disaster mitigation, search and rescue problem. A comprehensive urban disaster simulator is constructed on distributed computers. Heterogeneous intelligent agents such as fire fighters, victims and volunteers conduct search and rescue activities in this virtual disaster world. A real world interface integrates various sensor systems and controllers of infrastructures in the real cities with the real world. Real-time simulation is synchronized with actual disasters, computing complex relationship between various damage factors and agent behaviors. A mission-critical man-machine interface provides portability and robustness of disaster mitigation centers, and augmented-reality interfaces for rescue in real disasters. It also provides a virtual- reality training function for the public. This diverse spectrum of RoboCup-Rescue contributes to the creation of the safer social system.

Damage Control Plan for International Space Station Recharge Tank Assembly Composite Overwrapped Pressure Vessel

NASA Technical Reports Server (NTRS)

Cook, Anthony J.

2011-01-01

As NASA has retired the Space Shuttle Program, a new method of transporting compressed gaseous nitrogen and oxygen needed to be created for delivery of these crucial life support resources to the International Space Station (ISS). One of the methods selected by NASA includes the use of highly pressurized, unprotected Recharge Tank Assemblies (RTAs) utilizing Composite Overwrapped Pressure Vessels (COPVs). A COPV consists of a thin liner wrapped with a fiber composite and resin or epoxy. It is typically lighter weight than an all metal pressure vessel of similar volume and therefore provides a higher-efficiency means for gas storage. However COPVs are known to be susceptible to damage resulting from handling, tool drop impacts, or impacts from other objects. As a result, a comprehensive Damage Control Plan has been established to mitigate damage to the RTA COPV throughout its life cycle. The DCP is intended to evaluate and mitigate defined threats during manufacturing, shipping and handling, test, assembly level integration, shipment while pressurized, launch vehicle integration and mission operations by defining credible threats and methods for preventing potential damage while still maintaining the primary goal of resupplying ISS gas resources. A comprehensive threat assessment is performed to identify all threats posed to the COPV during the different phases of its lifecycle. The threat assessment is then used as the basis for creating a series of general inspection, surveillance and reporting requirements which apply across all phases of the COPV's life, targeted requirements only applicable to specific work phases and a series of training courses for both ground personnel and crew aboard the ISS. A particularly important area of emphasis deals with creating DCP requirements for a highly pressurized, large and unprotected RTA COPV for use during Inter Vehicular Activities (IVA) operations in the micro gravity environment while supplying pressurized gas to the ISS for crew life support.

Low doses of ionizing radiation to mammalian cells may rather control than cause DNA damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feinendegen, L.E.; Bond, V.P.; Sondhaus, C.A.

This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced metabolic changes that induce mechanisms of DNA damage mitigation, which do not operate at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in themore » low-dose region. This suggests that the LNT hypothesis should be reexamined. This paper aims at demonstrating tissue effects as an expression of cellular responses, both damaging and defensive, in relation to the energy deposited in cell mass, by use of microdosimetric concepts.« less

Push back to respond better: regulatory inhibition of the DNA double-strand break response.

PubMed

Panier, Stephanie; Durocher, Daniel

2013-10-01

Single DNA lesions such as DNA double-strand breaks (DSBs) can cause cell death or trigger genome rearrangements that have oncogenic potential, and so the pathways that mend and signal DNA damage must be highly sensitive but, at the same time, selective and reversible. When initiated, boundaries must be set to restrict the DSB response to the site of the lesion. The integration of positive and, crucially, negative control points involving post-translational modifications such as phosphorylation, ubiquitylation and acetylation is key for building fast, effective responses to DNA damage and for mitigating the impact of DNA lesions on genome integrity.

Evaluation of environmental health benefits of China's building energy conservation policies: an integrated assessment on national and provincial levels.

PubMed

Yang, Xi; Xi, Xiaoqian; Lin, Wanqi; Guo, Shan; Feng, Xiangzhao; Gilmore, Elisabeth

2018-05-04

This article evaluates the effect of energy conservation policies and carbon mitigation efforts on reducing health damage in China's building sector, which has been long ignored. The study bases on both national and provincial levels. To evaluate the health damage effect, we use domestic data by region to ensure the reliability of the evaluation. Results show that in the co-control scenario, the GDP loss saved from health benefit in 2020, 2030, and 2050 is 0.13 %, 0.16 %, and 0.23 %, respectively, compared to reference scenario. At a provincial level, extra health benefit of 16, 16, 33, 25, and 23 RMB/person can be observed for Beijing, Heilongjiang, Guangdong, Henan, and Qinghai owing to energy conservation, even with the strictest end-of-pipe control measures. The results confirm the significant effect of energy conservation efforts on reducing the health damage in China's building sector at both national and provincial levels.

Handbook on Coral Reef Impacts: Avoidance, Minimization, Compensatory Mitigation, and Restoration

EPA Pesticide Factsheets

This Handbook provides a general summary of current avoidance, minimization, compensatory mitigation, and restoration strategies that may help address physical damage resulting from direct adverse impacts to coral reefs.

Scour damage to Vermont bridges and scour monitoring.

DOT National Transportation Integrated Search

2015-06-01

Scour is by far the primary cause of bridge failures in the United States. Regionally, the : vulnerability of bridges to flood damage became evident from the damage seen to Vermont : bridges in the 2011 Tropical Storm Irene. Successfully mitigating s...

Endovascular Catheter for Magnetic Navigation under MR Imaging Guidance: Evaluation of Safety in Vivo at 1.5T

PubMed Central

Hetts, S.W.; Saeed, M.; Martin, A.J.; Evans, L.; Bernhardt, A.F.; Malba, V.; Settecase, F.; Do, L.; Yee, E.J.; Losey, A.; Sincic, R.; Roy, S.; Arenson, R.L.; Wilson, M.W.

2013-01-01

BACKGROUND AND PURPOSE: Endovascular navigation under MR imaging guidance can be facilitated by a catheter with steerable microcoils on the tip. Not only do microcoils create visible artifacts allowing catheter tracking, but also they create a small magnetic moment permitting remote-controlled catheter tip deflection. A side product of catheter tip electrical currents, however, is the heat that might damage blood vessels. We sought to determine the upper boundary of electrical currents safely usable at 1.5T in a coil-tipped microcatheter system. MATERIALS AND METHODS: Alumina tubes with solenoid copper coils were attached to neurovascular microcatheters with heat shrink-wrap. Catheters were tested in carotid arteries of 8 pigs. The catheters were advanced under x-ray fluoroscopy and MR imaging. Currents from 0 mA to 700 mA were applied to test heating and potential vascular damage. Postmortem histologic analysis was the primary endpoint. RESULTS: Several heat-mitigation strategies demonstrated negligible vascular damage compared with control arteries. Coil currents ≤300 mA resulted in no damage (0/58 samples) compared with 9 (25%) of 36 samples for > 300-mA activations (P = .0001). Tip coil activation ≤1 minute and a proximal carotid guide catheter saline drip > 2 mL/minute also had a nonsignificantly lower likelihood of vascular damage. For catheter tip coil activations ≤300 mA for ≤1 minute in normal carotid flow, 0 of 43 samples had tissue damage. CONCLUSIONS: Activations of copper coils at the tip of microcatheters at low currents in 1.5T MR scanners can be achieved without significant damage to blood vessel walls in a controlled experimental setting. Further optimization of catheter design and procedure protocols is necessary for safe remote control magnetic catheter guidance. PMID:23846795

Direct and Pollinator-Mediated Effects of Herbivory on Strawberry and the Potential for Improved Resistance

PubMed Central

Muola, Anne; Weber, Daniela; Malm, Lisa E.; Egan, Paul A.; Glinwood, Robert; Parachnowitsch, Amy L.; Stenberg, Johan A.

2017-01-01

The global decline in pollinators has partly been blamed on pesticides, leading some to propose pesticide-free farming as an option to improve pollination. However, herbivores are likely to be more prevalent in pesticide-free environments, requiring knowledge of their effects on pollinators, and alternative crop protection strategies to mitigate any potential pollination reduction. Strawberry leaf beetles (SLB) Galerucella spp. are important strawberry pests in Northern Europe and Russia. Given that SLB attack both leaf and flower tissue, we hypothesized pollinators would discriminate against SLB-damaged strawberry plants (Fragaria vesca, cultivar ‘Rügen’), leading to lower pollination success and yield. In addition we screened the most common commercial cultivar ‘Rügen’ and wild Swedish F. vesca genotypes for SLB resistance to assess the potential for inverse breeding to restore high SLB resistance in cultivated strawberry. Behavioral observations in a controlled experiment revealed that the local pollinator fauna avoided strawberry flowers with SLB-damaged petals. Low pollination, in turn, resulted in smaller more deformed fruits. Furthermore, SLB-damaged flowers produced smaller fruits even when they were hand pollinated, showing herbivore damage also had direct effects on yield, independent of indirect effects on pollination. We found variable resistance in wild woodland strawberry to SLB and more resistant plant genotypes than the cultivar ‘Rügen’ were identified. Efficient integrated pest management strategies should be employed to mitigate both direct and indirect effects of herbivory for cultivated strawberry, including high intrinsic plant resistance. PMID:28572811

Small Gas Bubble Experiment for Mitigation of Cavitation Damage and Pressure Waves in Short-pulse Mercury Spallation Targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wendel, Mark W; Felde, David K; Sangrey, Robert L

2014-01-01

Populations of small helium gas bubbles were introduced into a flowing mercury experiment test loop to evaluate mitigation of beam-pulse induced cavitation damage and pressure waves. The test loop was developed and thoroughly tested at the Spallation Neutron Source (SNS) prior to irradiations at the Los Alamos Neutron Science Center - Weapons Neutron Research Center (LANSCE-WNR) facility. Twelve candidate bubblers were evaluated over a range of mercury flow and gas injection rates by use of a novel optical measurement technique that accurately assessed the generated bubble size distributions. Final selection for irradiation testing included two variations of a swirl bubblermore » provided by Japan Proton Accelerator Research Complex (J-PARC) collaborators and one orifice bubbler developed at SNS. Bubble populations of interest consisted of sizes up to 150 m in radius with achieved gas void fractions in the 10^-5 to 10^-4 range. The nominal WNR beam pulse used for the experiment created energy deposition in the mercury comparable to SNS pulses operating at 2.5 MW. Nineteen test conditions were completed each with 100 pulses, including variations on mercury flow, gas injection and protons per pulse. The principal measure of cavitation damage mitigation was surface damage assessment on test specimens that were manually replaced for each test condition. Damage assessment was done after radiation decay and decontamination by optical and laser profiling microscopy with damaged area fraction and maximum pit depth being the more valued results. Damage was reduced by flow alone; the best mitigation from bubble injection was between half and a quarter that of flow alone. Other data collected included surface motion tracking by three laser Doppler vibrometers (LDV), loop wall dynamic strain, beam diagnostics for charge and beam profile assessment, embedded hydrophones and pressure sensors, and sound measurement by a suite of conventional and contact microphones.« less

An Assessment of Molecular Dynamic Force Fields for Silica for Use in Simulating Laser Damage Mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soules, T F; Gilmer, G H; Matthews, M J

2010-10-21

We compare force fields (FF's) that have been used in molecular dynamic (MD) simulations of silica in order to assess their applicability for use in simulating IR-laser damage mitigation. Although pairwise FF?s obtained by fitting quantum mechanical calculations such as the BKS and CHIK potentials have been shown to reproduce many of the properties of silica including the stability of silica polymorphs and the densification of the liquid, we show that melting temperatures and fictive temperatures are much too high. Softer empirical force fields give liquid and glass properties at experimental temperatures but may not predict all properties important tomore » laser mitigation experiments.« less

Biocontamination Control for Spacesuit Garments - A Preliminary Study

NASA Technical Reports Server (NTRS)

Rhodes, Richard A.; Orndoff, Evelyne; Korona, F. Adam; Poritz, Darwin; Smith, Jelanie; Wong, Wing

2011-01-01

This paper outlines a preliminary study that was conducted to review, test, and improve on current space suit biocontamination control. Biocontamination from crew members can cause space suit damage and objectionable odors and lead to crew member health hazards. An understanding of the level of biocontamination is necessary to mitigate its effects. A series of tests were conducted with the intent of evaluating current suit materials, ground and on-orbit disinfectants, and potential commercial off-the-shelf antimicrobial materials. Included in this paper is a discussion of the test methodology, results, and analysis method.

Modelling large floating bodies in urban area flash-floods via a Smoothed Particle Hydrodynamics model

NASA Astrophysics Data System (ADS)

Albano, Raffaele; Sole, Aurelia; Mirauda, Domenica; Adamowski, Jan

2016-10-01

Large debris, including vehicles parked along floodplains, can cause severe damage and significant loss of life during urban area flash-floods. In this study, the authors validated and applied the Smoothed Particle Hydrodynamics (SPH) model, developed in Amicarelli et al. (2015), which reproduces in 3D the dynamics of rigid bodies driven by free surface flows, to the design of flood mitigation measures. To validate the model, the authors compared the model's predictions to the results of an experimental setup, involving a dam breach that strikes two fixed obstacles and three transportable floating bodies. Given the accuracy of the results, in terms of water depth over time and the time history of the bodies' movements, the SPH model explored in this study was used to analyse the mitigation efficiency of a proposed structural intervention - the use of small barriers (groynes) to prevent the transport of floating bodies. Different groynes configurations were examined to identify the most appropriate design and layout for urban area flash-flood damage mitigation. The authors found that groynes positioned upstream and downstream of each floating body can be effective as a risk mitigation measure for damage resulting from their movement.

Eye Disease Resulting From Increased Use of Fluorescent Lighting as a Climate Change Mitigation Strategy

PubMed Central

Walls, Kelvin L.; Benke, Geza

2011-01-01

Increased use of fluorescent lighting as a climate change mitigation strategy may increase eye disease. The safe range of light to avoid exposing the eye to potentially damaging ultraviolet (UV) radiation is 2000 to 3500K and greater than 500 nanometers. Some fluorescent lights fall outside this safe range. Fluorescent lighting may increase UV-related eye diseases by up to 12% and, according to our calculations, may cause an additional 3000 cases of cataracts and 7500 cases of pterygia annually in Australia. Greater control of UV exposure from fluorescent lights is required. This may be of particular concern for aging populations in developed countries and countries in northern latitudes where there is a greater dependence on artificial lighting. PMID:22021286

Co-Optima Highlights Primary Causes of Misfueling and Mitigation Strategies

Science.gov Websites

% ethanol; 90% unleaded gasoline) for use in any gasoline vehicle. Many misfueling mitigation measures such lead to vehicle systems damage. Measures such as nozzle colors are not universally standardized. Fuel

Development, Modeling and Test of Optical Coatings with Novel Thermal and Stress Management for High Energy Laser Applications

DTIC Science & Technology

2017-01-11

and to mitigate the defects in the coating that lead to damage under laser irradiation . In this final 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND...understand and to mitigate the defects in the coating that lead to damage under laser irradiation . In this final report we list the accomplishments of this...Luke A. Emmert, Wolfgang Rudolph. Time-dependent absorption of TiO_2 optical thin films under pulsed and continuous wave 790??nm laser irradiation

Managing U.S. climate risk through mitigation: Insights from the American Climate Prospectus

NASA Astrophysics Data System (ADS)

Kopp, R. E., III; Hsiang, S. M.; Houser, T.; Larsen, K.; Rasmussen, D. M., Jr.; Jina, A.; Rising, J.; Delgado, M.; Mohan, S.; Muir-Wood, R.; Wilson, P. S.

2014-12-01

The American Climate Prospectus (ACP), the technical analysis underlying the Risky Business project, quantitatively assessed the economic risks posed to the United States by six categories of climate change impacts: crop yield, energy demand, coastal storm damage, criminal activity, labor productivity, and mortality [1]. At a national level, measured by impact on gross domestic product, increased mortality and decreased labor productivity pose the large risks, followed by increased energy demand and coastal damages. Changes in crop yield and crime have smaller impacts. The ACP was not intended to conduct a benefit-cost analysis of climate change mitigation. It assessed the economic consequences of future impacts on an economy with a structure equivalent to that of the current economy, not accounting for socio-economic development and adaptation, and did not assess the cost of mitigation. One of its primary goals was to inform adaptation decisions that are conventionally considered 'endogenous' in economic analyses of climate change. Nonetheless, its results provide insight into the potential of mitigation to manage climate risk. Differences between RCP 8.5 (moderately-high business-as-usual emissions), RCP 4.5 (moderate mitigation) and RCP 2.6 (extremely strong mitigation) are not apparent until mid-century and become significant only late in the century. For all impacts except coastal damages, mitigation significantly reduces uncertainty in late-century impact estimates. Nationally, mitigation significantly and monotonically reduces median projected labor productivity losses and violent crime. Switching from RCP 8.5 to RCP 4.5 also significantly reduces median projections of mortality and energy demand, but the domestic value to the U.S. of further mitigation to RCP 2.6 is less clear. The marginal benefits decline in part because some regions of the country (especially the Northwest) may experience increased crop yields, reduced mortality, and reduced energy demand under all RCPs. Because of the slow response time of sea level to change in emissions, the coastal risk reduction in the current century from mitigation is least clear. References: [1] T. Houser et al. (2014), American Climate Prospectus, www.climateprospectus.org.

Acute Blood Loss During Burn and Soft Tissue Excisions: An Observational Study of Blood Product Resuscitation Practices and Focused Review

DTIC Science & Technology

2015-06-24

centers have shifted to a damage-control resuscitation approach, focused on providing oxygen - carrying capacity while simultaneously mitigating...develop treatments for this widely recognized problem have yet to yield effective solutions. In both the ci- vilian and military settings, most deaths...characterizing the effects of significant intraoperative bleeding on coagulation may be an alternative source of data to guide ORIGINAL ARTICLE J

Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma

DTIC Science & Technology

2007-02-01

FACS, Jay Johannigman, MD, FS, FACS, Peter Mahoney, FRCA, RAMC , Sumeru Mehta, MD, E. Darrin Cox, MD, FACS, Michael J. Gehrke, MD, Greg J. Beilman, MD...opportunity to formally evaluate the immediate and direct treatment of the coagulopathy of trauma is available. Submitted for publication September 22, 2006...the results were not evaluated in randomized human trials.33–35 Additionally, the potential benefits of mitigating ischemia-induced reperfusion injury

A Response Surface Methodology for Mitigating Hot Gasses in Enclosed Car Park

NASA Astrophysics Data System (ADS)

Faiz Tharima, Ahmad; Zamri Yusoff, Mohd; Mujibur Rahman, Md

2017-12-01

A hot gas rise towards ceiling due to fire buoyancy will cause severe damage to the building structure. The temperature rises need to be controlled as among the elements of compliance in performance-based design. The channel flow between beams has used in this study to mitigate hot gases out of the enclosure by mean of response surface methodology. Fire Dynamic Simulator was employed as a simulation tool while the result was statistically examined using analysis of variance via Minitab application. It was found that the result was linear with predicted R2 (93.25%) and within the permissible R2 (98.13%). The ceiling height has been identified not affect in controlling hot gases while four control parameters which are beam spacing, transversal beam, extraction rate and longitudinal beam with p-values of 0.00, 0.000, 0.023 and 0.000 respectively, have been found to have the significant effect on the smoke temperature control. This study contributes a good input to the fire safety community in providing the initial design of enclosed car park with better condition.

Mitigation in Multiple Effects of Graphene Oxide Toxicity in Zebrafish Embryogenesis Driven by Humic Acid.

PubMed

Chen, Yuming; Ren, Chaoxiu; Ouyang, Shaohu; Hu, Xiangang; Zhou, Qixing

2015-08-18

Graphene oxide (GO) is a widely used carbonaceous nanomaterial. To date, the influence of natural organic matter (NOM) on GO toxicity in aquatic vertebrates has not been reported. During zebrafish embryogenesis, GO induced a significant hatching delay and cardiac edema. The intensive interactions of GO with the chorion induces damage to chorion protuberances, excessive generation of (•)OH, and changes in protein secondary structure. In contrast, humic acid (HA), a ubiquitous form of NOM, significantly relieved the above adverse effects. HA reduced the interactions between GO and the chorion and mitigated chorion damage by regulating the morphology, structures, and surface negative charges of GO. HA also altered the uptake and deposition of GO and decreased the aggregation of GO in embryonic yolk cells and deep layer cells. Furthermore, HA mitigated the mitochondrial damage and oxidative stress induced by GO. This work reveals a feasible antidotal mechanism for GO in the presence of NOM and avoids overestimating the risks of GO in the natural environment.

Physiological and Metabolic Effects of 5-Aminolevulinic Acid for Mitigating Salinity Stress in Creeping Bentgrass

PubMed Central

Yang, Zhimin; Chang, Zuoliang; Sun, Lihong; Yu, Jingjin; Huang, Bingru

2014-01-01

The objectives of this study were to determine whether foliar application of a chlorophyll precursor, 5-aminolevulinic acid (ALA), could mitigate salinity stress damages in perennial grass species by regulating photosynthetic activities, ion content, antioxidant metabolism, or metabolite accumulation. A salinity-sensitive perennial grass species, creeping bentgrass (Agrostis stolonifera), was irrigated daily with 200 mM NaCl for 28 d, which were foliar sprayed with water or ALA (0.5 mg L−1) weekly during the experiment in growth chamber. Foliar application of ALA was effective in mitigating physiological damage resulting from salinity stress, as manifested by increased turf quality, shoot growth rate, leaf relative water content, chlorophyll content, net photosynthetic rate, stomatal conductance and transpiration rate. Foliar application of ALA also alleviated membrane damages, as shown by lower membrane electrolyte leakage and lipid peroxidation, which was associated with increases in the activities of antioxidant enzymes. Leaf content of Na+ was reduced and the ratio of K+/Na+ was increased with ALA application under salinity stress. The positive effects of ALA for salinity tolerance were also associated with the accumulation of organic acids (α-ketoglutaric acid, succinic acid, and malic acid), amino acids (alanine, 5-oxoproline, aspartic acid, and γ -aminobutyric acid), and sugars (glucose, fructose, galactose, lyxose, allose, xylose, sucrose, and maltose). ALA-mitigation of physiological damages by salinity could be due to suppression of Na+ accumulation and enhanced physiological and metabolic activities related to photosynthesis, respiration, osmotic regulation, and antioxidant defense. PMID:25551443

Design of Life Extending Controls Using Nonlinear Parameter Optimization

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Holmes, Michael S.; Ray, Asok

1998-01-01

This report presents the conceptual development of a life extending control system where the objective is to achieve high performance and structural durability of the plant. A life extending controller is designed for a reusable rocket engine via damage mitigation in both the fuel and oxidizer turbines while achieving high performance for transient responses of the combustion chamber pressure and the O2/H2 mixture ratio. This design approach makes use of a combination of linear and nonlinear controller synthesis techniques and also allows adaptation of the life extending controller module to augment a conventional performance controller of a rocket engine. The nonlinear aspect of the design is achieved using nonlinear parameter optimization of a prescribed control structure.

Mechanoresponsive Healing Polymers

NASA Technical Reports Server (NTRS)

Siochi, Emilie J. (Inventor); Gordon, Keith L. (Inventor)

2018-01-01

Methods are provided to produce new mechanoresponsive healing systems. Additionally, various embodiments provide a two tier self-healing material system concept that provides a non-intrusive method to mitigate impact damage in a structure ranging from low velocity impact damage (e.g., crack damage) to high velocity impact damage (e.g., ballistic damage.) The various embodiments provide the mechanophore linked polymer PBG-BCB-PBG. The various embodiments provide methods for synthesizing PBG-BCB-PBG.

Electron beam induced radiation damage in the catalyst layer of a proton exchange membrane fuel cell.

PubMed

He, Qianping; Chen, Jihua; Keffer, David J; Joy, David C

2014-01-01

Electron microscopy is an essential tool for the evaluation of microstructure and properties of the catalyst layer (CL) of proton exchange membrane fuel cells (PEMFCs). However, electron microscopy has one unavoidable drawback, which is radiation damage. Samples suffer temporary or permanent change of the surface or bulk structure under radiation damage, which can cause ambiguity in the characterization of the sample. To better understand the mechanism of radiation damage of CL samples and to be able to separate the morphological features intrinsic to the material from the consequences of electron radiation damage, a series of experiments based on high-angle annular dark-field-scanning transmission scanning microscope (HAADF-STEM), energy filtering transmission scanning microscope (EFTEM), and electron energy loss spectrum (EELS) are conducted. It is observed that for thin samples (0.3-1 times λ), increasing the incident beam energy can mitigate the radiation damage. Platinum nanoparticles in the CL sample facilitate the radiation damage. The radiation damage of the catalyst sample starts from the interface of Pt/C or defective thin edge and primarily occurs in the form of mass loss accompanied by atomic displacement and edge curl. These results provide important insights on the mechanism of CL radiation damage. Possible strategies of mitigating the radiation damage are provided. © 2013 Wiley Periodicals, Inc.

Mitigation of Debris Flow Damage--­ A Case Study of Debris Flow Damage

NASA Astrophysics Data System (ADS)

Lin, J. C.; Jen, C. H.

Typhoon Toraji caused more than 30 casualties in Central Taiwan on the 31st July 2001. It was the biggest Typhoon since the Chi-Chi earthquake of 1999 with huge amounts of rainfall. Because of the influence of the earthquake, loose debris falls and flows became major hazards in Central Taiwan. Analysis of rainfall data and sites of slope failure show that damage from these natural hazards were enhanced as a result of the Chi-Chi earthquake. Three main types of hazard occurred in Central Taiwan: land- slides, debris flows and gully erosion. Landslides occurred mainly along hill slopes and banks of channels. Many dams and houses were destroyed by flooding. Debris flows occurred during typhoon periods and re-activated ancient debris depositions. Many new gullies were therefore developed from deposits loosened and shaken by the earthquake. This paper demonstrates the geological/geomorphological background of the hazard area, and reviews methods of damage mitigation in central Taiwan. A good example is Hsi-Tou, which had experienced no gully erosion for more than 40 years. The area experienced much gully erosion as a result of the combined effects of earth- quake and typhoon. Although Typhoon Toraji produced only 30% of the rainfall of Typhoon Herb of 1996, it caused more damage in the Hsi-Tou area. The mitigation of debris flow hazards in Hsi-tou area is discussed in this paper.

Geo-infrastructure damage assessment, repair and mitigation strategies.

DOT National Transportation Integrated Search

2013-09-01

The 2011 Missouri River flooding caused significant damage to many geo-infrastructure systems including levees, bridge : abutments/foundations, paved and unpaved roadways, culverts, and embankment slopes in western Iowa. The flooding resulted in : cl...

Mitigation of Shore Damage Attributed to the Federal Navigation Structures at Port Sanilac Harbor, Michigan.

DTIC Science & Technology

1975-09-01

beach would be more costly tiian the stockpile method of placement considered for the feeder proposal. 5. COMMENTS REQUESTED: The Draft and this...contractual, and methods of detectinq and avoiding pollution to prevent and correct environmental pollution. QUALITY CONTROL 1.34 The contractor (if...Reliahle ;reat ,,kes wave data measured by wave rnauces are nearly nonexistent for statistical t:eatment. An indirect method of develoz’ina wave data is

Great East Japan earthquake, JR East mitigation successes, and lessons for California high-speed rail.

DOT National Transportation Integrated Search

2015-04-01

California and Japan both experience frequent seismic activity, which is often damaging to infrastructure. Seismologists have : developed systems for detecting and analyzing earthquakes in real-time. JR East has developed systems to mitigate the : da...

Preventing Unofficial Information Propagation

NASA Astrophysics Data System (ADS)

Le, Zhengyi; Ouyang, Yi; Xu, Yurong; Ford, James; Makedon, Fillia

Digital copies are susceptible to theft and vulnerable to leakage, copying, or manipulation. When someone (or some group), who has stolen, leaked, copied, or manipulated digital documents propagates the documents over the Internet and/or distributes those through physical distribution channels many challenges arise which document holders must overcome in order to mitigate the impact to their privacy or business. This paper focuses on the propagation problem of digital credentials, which may contain sensitive information about a credential holder. Existing work such as access control policies and the Platform for Privacy Preferences (P3P) assumes that qualified or certified credential viewers are honest and reliable. The proposed approach in this paper uses short-lived credentials based on reverse forward secure signatures to remove this assumption and mitigate the damage caused by a dishonest or honest but compromised viewer.

Development of Real-Time System for Urban Flooding by Surcharge of Storm Drainge and River Inundation

NASA Astrophysics Data System (ADS)

Shim, J. B.; Won, C. Y.; Park, J.; Lee, K.

2017-12-01

Korea experiences frequent flood disasters, which cause considerable economic losses and damages to towns and farms. Especially, a regional torrential storm is about 98.5mm/hr on September 21, 2010 in Seoul. The storm exceeds the capacity of urban drainage system of 75mm/hr, and 9,419 houses. How to monitor and control the urban flood disasters is an important issue in Korea. To mitigate the flood damage, a customizing system was developed to estimate urban floods and inundation using by integrating drainage system data and river information database which are managed by local governments and national agencies. In the case of Korean urban city, there are a lot of detention ponds and drainage pumping stations on end of drainage system and flow is going into river. The drainage pumping station, it is very important hydraulic facility for flood control between river and drainage system. So, it is possible to occur different patterns of flood inundation according to operation rule of drainage pumping station. A flood disaster is different damage as how to operate drainage pumping station and plan operation rule.

Failure and recovery in dynamical networks.

PubMed

Böttcher, L; Luković, M; Nagler, J; Havlin, S; Herrmann, H J

2017-02-03

Failure, damage spread and recovery crucially underlie many spatially embedded networked systems ranging from transportation structures to the human body. Here we study the interplay between spontaneous damage, induced failure and recovery in both embedded and non-embedded networks. In our model the network's components follow three realistic processes that capture these features: (i) spontaneous failure of a component independent of the neighborhood (internal failure), (ii) failure induced by failed neighboring nodes (external failure) and (iii) spontaneous recovery of a component. We identify a metastable domain in the global network phase diagram spanned by the model's control parameters where dramatic hysteresis effects and random switching between two coexisting states are observed. This dynamics depends on the characteristic link length of the embedded system. For the Euclidean lattice in particular, hysteresis and switching only occur in an extremely narrow region of the parameter space compared to random networks. We develop a unifying theory which links the dynamics of our model to contact processes. Our unifying framework may help to better understand controllability in spatially embedded and random networks where spontaneous recovery of components can mitigate spontaneous failure and damage spread in dynamical networks.

Electrical Characterizations of Lightning Strike Protection Techniques for Composite Materials

NASA Technical Reports Server (NTRS)

Szatkowski, George N.; Nguyen, Truong X.; Koppen, Sandra V.; Ely, Jay J.; Mielnik, John J.

2009-01-01

The growing application of composite materials in commercial aircraft manufacturing has significantly increased the risk of aircraft damage from lightning strikes. Composite aircraft designs require new mitigation strategies and engineering practices to maintain the same level of safety and protection as achieved by conductive aluminum skinned aircraft. Researchers working under the NASA Aviation Safety Program s Integrated Vehicle Health Management (IVHM) Project are investigating lightning damage on composite materials to support the development of new mitigation, diagnosis & prognosis techniques to overcome the increased challenges associated with lightning protection on composite aircraft. This paper provides an overview of the electrical characterizations being performed to support IVHM lightning damage diagnosis research on composite materials at the NASA Langley Research Center.

Precision machining of pig intestine using ultrafast laser pulses

NASA Astrophysics Data System (ADS)

Beck, Rainer J.; Góra, Wojciech S.; Carter, Richard M.; Gunadi, Sonny; Jayne, David; Hand, Duncan P.; Shephard, Jonathan D.

2015-07-01

Endoluminal surgery for the treatment of early stage colorectal cancer is typically based on electrocautery tools which imply restrictions on precision and the risk of harm through collateral thermal damage to the healthy tissue. As a potential alternative to mitigate these drawbacks we present laser machining of pig intestine by means of picosecond laser pulses. The high intensities of an ultrafast laser enable nonlinear absorption processes and a predominantly nonthermal ablation regime. Laser ablation results of square cavities with comparable thickness to early stage colorectal cancers are presented for a wavelength of 1030 nm using an industrial picosecond laser. The corresponding histology sections exhibit only minimal collateral damage to the surrounding tissue. The depth of the ablation can be controlled precisely by means of the pulse energy. Overall, the application of ultrafast lasers to ablate pig intestine enables significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional techniques.

Radon inhalation protects against transient global cerebral ischemic injury in gerbils.

PubMed

Kataoka, Takahiro; Etani, Reo; Takata, Yuji; Nishiyama, Yuichi; Kawabe, Atsushi; Kumashiro, Masayuki; Taguchi, Takehito; Yamaoka, Kiyonori

2014-10-01

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m(3) for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

PDC bits break ground with advanced vibration mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-10-01

Advancements in PDC bit technology have resulted in the identification and characterization of different types of vibrational modes that historically have limited PDC bit performance. As a result, concepts have been developed that prevent the initiation of vibration and also mitigate its damaging effects once it occurs. This vibration-reducing concept ensures more efficient use of the energy available to a PDC bit performance. As a result, concepts have been developed that prevent the imitation of vibration and also mitigate its damaging effects once it occurs. This vibration-reducing concept ensures more efficient use of the energy available to a PDC bit,more » thereby improving its performance. This improved understanding of the complex forces affecting bit performance is driving bit customization for specific drilling programs.« less

Evaluation of urban flood damages in climate and land use changes: Case Studies from Southeast Asia

NASA Astrophysics Data System (ADS)

Kefi, M.; Binaya, M. K.; Kumar, P.; Fukushi, K.

2017-12-01

Urbanization, changes in land use and global warming increase the threat of natural disasters such as flooding. In recent decades, it was observed a rise of intensity and frequency of flood events. The exposure both of people and the national economy to flood hazards is amplified and can induce serious economic and social damages. For this reason, local governments adopted several strategies to cope with flood risk in urban areas in particular, but a better comprehension of the flood hazard factors may enhance the efficiency of mitigating measures overall. For this research, a spatial analysis is applied to estimate future direct flood damage for 2030 in three Southeast Asian megacities: Jakarta (Indonesia), Metro-Manila (Philippines) and Hanoi (Vietnam). This comprehensive method combined flood characteristics (flood depth) obtained from flood simulation using FLO-2D, land use generated from supervised classification and remote sensing products, property value of affected buildings and flood damage rate derived from flood depth function. This function is established based on field surveys with local people affected by past flood events. Additionally, two scenarios were analyzed to simulate the future conditions. The first one is related to climate change and it is based on several General Circulation Models (GCMs). However, the second one is establish to point out the effect of adaptation strategies. The findings shows that the climate change combined with the expansion of built-up areas increase the vulnerability of urban areas to flooding and the economic damage. About 16%, 8% and 19% of flood inundation areas are expected to increase respectively in Metro-Manila, Jakarta and Hanoi. However, appropriate flood control measures can be helpful to reduce the impact of natural disaster. Furthermore, flood damage maps are generated at a large scale, which can be helpful to local stakeholders when prioritizing their mitigation strategies on urban disaster resilience.

Strategically placing green infrastructure: cost-effective land conservation in the floodplain.

PubMed

Kousky, Carolyn; Olmstead, Sheila M; Walls, Margaret A; Macauley, Molly

2013-04-16

Green infrastructure approaches have attracted increased attention from local governments as a way to lower flood risk and provide an array of other environmental services. The peer-reviewed literature, however, offers few estimates of the economic impacts of such approaches at the watershed scale. We estimate the avoided flood damages and the costs of preventing development of floodplain parcels in the East River Watershed of Wisconsin's Lower Fox River Basin. Results suggest that the costs of preventing conversion of all projected floodplain development would exceed the flood damage mitigation benefits by a substantial margin. However, targeting of investments to high-benefit, low-cost parcels can reverse this equation, generating net benefits. The analysis demonstrates how any flood-prone community can use a geographic-information-based model to estimate the flood damage reduction benefits of green infrastructure, compare them to the costs, and target investments to design cost-effective nonstructural flood damage mitigation policies.

Assessment and Mitigation of Electromagnetic Pulse (EMP) Impacts at Short-pulse Laser Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Jr., C G; Bond, E; Clancy, T

2009-10-02

The National Ignition Facility (NIF) will be impacted by electromagnetic pulse (EMP) during normal long-pulse operation, but the largest impacts are expected during short-pulse operation utilizing the Advanced Radiographic Capability (ARC). Without mitigation these impacts could range from data corruption to hardware damage. We describe our EMP measurement systems on Titan and NIF and present some preliminary results and thoughts on mitigation.

Assessment and Mitigation of Electromagnetic Pulse (EMP) Impacts at Short-pulse Laser Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Jr., C G; Bond, E; Clancy, T

2010-02-04

The National Ignition Facility (NIF) will be impacted by electromagnetic pulse (EMP) during normal long-pulse operation, but the largest impacts are expected during short-pulse operation utilizing the Advanced Radiographic Capability (ARC). Without mitigation these impacts could range from data corruption to hardware damage. We describe our EMP measurement systems on Titan and NIF and present some preliminary results and thoughts on mitigation.

US PWR steam generator management: An overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Welty, C.S. Jr.

1997-02-01

This paper provides an overview on the status of steam generator management activities in US PWRs, and includes: (1) an overview of the impact of steam generator problems; (2) a brief discussion of historical damage trends and the current damage mechanism of most concern; (3) a discussion of the elements of {open_quotes}steam generator management{close_quotes}; and (4) a description of the approach being followed to implement a degradation-specific protocol for tubing inspection and repair. This paper was prepared in conjunction with another paper presented during the Plenary Session of this Conference, {open_quotes}Steam Generator Degradation: Current Mitigation Strategies for Controlling Corrosion{close_quotes}, andmore » is provided as a supplement to that material.« less

Playing against nature: improving earthquake hazard mitigation

NASA Astrophysics Data System (ADS)

Stein, S. A.; Stein, J.

2012-12-01

The great 2011 Tohoku earthquake dramatically demonstrated the need to improve earthquake and tsunami hazard assessment and mitigation policies. The earthquake was much larger than predicted by hazard models, and the resulting tsunami overtopped coastal defenses, causing more than 15,000 deaths and $210 billion damage. Hence if and how such defenses should be rebuilt is a challenging question, because the defences fared poorly and building ones to withstand tsunamis as large as March's is too expensive,. A similar issue arises along the Nankai Trough to the south, where new estimates warning of tsunamis 2-5 times higher than in previous models raise the question of what to do, given that the timescale on which such events may occur is unknown. Thus in the words of economist H. Hori, "What should we do in face of uncertainty? Some say we should spend our resources on present problems instead of wasting them on things whose results are uncertain. Others say we should prepare for future unknown disasters precisely because they are uncertain". Thus society needs strategies to mitigate earthquake and tsunami hazards that make economic and societal sense, given that our ability to assess these hazards is poor, as illustrated by highly destructive earthquakes that often occur in areas predicted by hazard maps to be relatively safe. Conceptually, we are playing a game against nature "of which we still don't know all the rules" (Lomnitz, 1989). Nature chooses tsunami heights or ground shaking, and society selects the strategy to minimize the total costs of damage plus mitigation costs. As in any game of chance, we maximize our expectation value by selecting the best strategy, given our limited ability to estimate the occurrence and effects of future events. We thus outline a framework to find the optimal level of mitigation by balancing its cost against the expected damages, recognizing the uncertainties in the hazard estimates. This framework illustrates the role of the uncertainties and the need to candidly assess them. It can be applied to exploring policies under various hazard scenarios and mitigating other natural hazards.ariation in total cost, the sum of expected loss and mitigation cost, as a function of mitigation level. The optimal level of mitigation, n*, minimizes the total cost. The expected loss depends on the hazard model, so the better the hazard model, the better the mitigation policy (Stein and Stein, 2012).

Implications of Climate Mitigation for Future Agricultural Production

NASA Technical Reports Server (NTRS)

Mueller, Christoph; Elliott, Joshua; Chryssanthacopoulos, James; Deryng, Delphine; Folberth, Christian; Pugh, Thomas A. M.; Schmid, Erwin

2015-01-01

Climate change is projected to negatively impact biophysical agricultural productivity in much of the world. Actions taken to reduce greenhouse gas emissions and mitigate future climate changes, are thus of central importance for agricultural production. Climate impacts are, however, not unidirectional; some crops in some regions (primarily higher latitudes) are projected to benefit, particularly if increased atmospheric carbon dioxide is assumed to strongly increase crop productivity at large spatial and temporal scales. Climate mitigation measures that are implemented by reducing atmospheric carbon dioxide concentrations lead to reductions both in the strength of climate change and in the benefits of carbon dioxide fertilization. Consequently, analysis of the effects of climate mitigation on agricultural productivity must address not only regions for which mitigation is likely to reduce or even reverse climate damages. There are also regions that are likely to see increased crop yields due to climate change, which may lose these added potentials under mitigation action. Comparing data from the most comprehensive archive of crop yield projections publicly available, we find that climate mitigation leads to overall benefits from avoided damages at the global scale and especially in many regions that are already at risk of food insecurity today. Ignoring controversial carbon dioxide fertilization effects on crop productivity, we find that for the median projection aggressive mitigation could eliminate approximately 81% of the negative impacts of climate change on biophysical agricultural productivity globally by the end of the century. In this case, the benefits of mitigation typically extend well into temperate regions, but vary by crop and underlying climate model projections. Should large benefits to crop yields from carbon dioxide fertilization be realized, the effects of mitigation become much more mixed, though still positive globally and beneficial in many food insecure countries.

Use of anticoagulant rodenticides in outdoor urban areas: considerations and proposals for the protection of public health and non-target species.

PubMed

Dutto, M; Di Domenico, D; Rubbiani, M

2018-01-01

Rodent control operations represent an important tool for the prevention and management of infestations, in outdoor environments, by synanthropic rodents (Rattus rattus and R. norvegicus), which are a source of economic and environmental damage with significant sanitary implications. Although the use of anticoagulants is safer to humans and pets compared to the use of acute poisoning substances, an intrinsic hazard of the active ingredients exists, i.e. the possible poisoning of non-target organisms (e.g., children, pets and wildlife) following exposure. The risks arising from the use of anticoagulants for rodent control operations in anthropic contexts can therefore only be mitigated by a proper selection of the active ingredient, bait formulation and administration techniques, since an active ingredient with selective action towards non-target species does not currently exist on the market. This document lists practical proposals aimed at reducing the possibility of toxic exposure to anticoagulant rodenticides and mitigate the toxicological risk of human baits and non-target species.

Temperature impacts on economic growth warrant stringent mitigation policy

NASA Astrophysics Data System (ADS)

Moore, Frances C.; Diaz, Delavane B.

2015-02-01

Integrated assessment models compare the costs of greenhouse gas mitigation with damages from climate change to evaluate the social welfare implications of climate policy proposals and inform optimal emissions reduction trajectories. However, these models have been criticized for lacking a strong empirical basis for their damage functions, which do little to alter assumptions of sustained gross domestic product (GDP) growth, even under extreme temperature scenarios. We implement empirical estimates of temperature effects on GDP growth rates in the DICE model through two pathways, total factor productivity growth and capital depreciation. This damage specification, even under optimistic adaptation assumptions, substantially slows GDP growth in poor regions but has more modest effects in rich countries. Optimal climate policy in this model stabilizes global temperature change below 2 °C by eliminating emissions in the near future and implies a social cost of carbon several times larger than previous estimates. A sensitivity analysis shows that the magnitude of climate change impacts on economic growth, the rate of adaptation, and the dynamic interaction between damages and GDP are three critical uncertainties requiring further research. In particular, optimal mitigation rates are much lower if countries become less sensitive to climate change impacts as they develop, making this a major source of uncertainty and an important subject for future research.

Geo-infrastructure post-flood damage assessment, repair and mitigation strategies : tech transfer summary.

DOT National Transportation Integrated Search

2013-09-01

The 2011 Missouri river flooding caused damage to many geoinfrastructure : systems including levees, bridge abutments/foundations, : paved and unpaved roadways, culverts, and embankment slopes in : western Iowa. The total reported direct cost to repa...

Combination Therapies for the Mitigation of Musculoskeletal Pathologic Damage in a Novel Model of Severe Injury and Disuse

DTIC Science & Technology

2016-10-01

and bone after injury and disuse are needed. Pharmacologic (i.e insulin or oxandrolone), non- pharmacologic (i.e. exercise) and nutritional ...catabolic response. Exercise and nutritional interventions have been used independently with limited success. The purpose of this study was to determine...Wolfe RR. Control of muscle protein breakdown: effects of activity and nutritional states. Int J Sport Nutr Exerc Metab. 2001; 11 Suppl:S164–169. [PubMed

Wildfire risk adaptation: propensity of forestland owners to purchase wildfire insurance in the southern United States

Treesearch

Jianbang Gan; Adam Jarrett; Cassandra Johnson Gaither

2014-01-01

Economic and ecological damages caused by wildfire are alarming, and such damages are expected to rise with changes in wildfire regimes, calling for more effective wildfire mitigation and adaptation strategies. Among wildfire adaptation options for forestland owners is purchasing wildfire insurance, which provides compensation to those insured if a wildfire damages...

Management of Field-Evolved Resistance to Bt Maize in Argentina: A Multi-Institutional Approach.

PubMed

Signorini, Ana M; Abratti, Gustavo; Grimi, Damián; Machado, Marcos; Bunge, Florencia F; Parody, Betiana; Ramos, Laura; Cortese, Pablo; Vesprini, Facundo; Whelan, Agustina; Araujo, Mónica P; Podworny, Mariano; Cadile, Alejandro; Malacarne, María F

2018-01-01

Evolution of resistance to control measures in insect populations is a natural process, and management practices are intended to delay or mitigate resistance when it occurs. During the 2012/13 season the first reports of unexpected damage by Diatraea saccharalis on some Bt maize hybrids occurred in the northeast of San Luis province, Argentina. The affected Bt technologies were Herculex I® (HX-TC1507) and VT3PRO® (MON 89034 × MON 88017 * ). Event TC1507 expresses Cry1F and event MON 89034 expresses Cry1A.105 and Cry2Ab2, whichr are all Bt proteins with activity against the lepidopterans D. saccharalis and Spodoptera frugiperda (MON 88017 expresses the protein Cry3Bb1 for control of coleopteran insects and the enzyme CP4EPSPS for glyphosate tolerance). The affected area is an isolated region surrounded by sierra systems to the northeast and west, with a hot semi-arid climate, long frost-free period, warm winters, hot dry summers, and woody shrubs as native flora. To manage and mitigate the development of resistance, joint actions were taken by the industry, growers and Governmental Agencies. Hybrids expressing Vip3A protein (event MIR162) and/or Cry1Ab protein (events MON 810 and Bt11) as single or stacked events are used in early plantings to control the first generations of D. saccharalis , and in later plantings date's technologies with good control of S. frugiperda . A commitment was made to plant the refuge, and pest damage is monitored. As a result, maize production in the area is sustainable and profitable with yields above the average.

Management of Field-Evolved Resistance to Bt Maize in Argentina: A Multi-Institutional Approach

PubMed Central

Signorini, Ana M.; Abratti, Gustavo; Grimi, Damián; Machado, Marcos; Bunge, Florencia F.; Parody, Betiana; Ramos, Laura; Cortese, Pablo; Vesprini, Facundo; Whelan, Agustina; Araujo, Mónica P.; Podworny, Mariano; Cadile, Alejandro; Malacarne, María F.

2018-01-01

Evolution of resistance to control measures in insect populations is a natural process, and management practices are intended to delay or mitigate resistance when it occurs. During the 2012/13 season the first reports of unexpected damage by Diatraea saccharalis on some Bt maize hybrids occurred in the northeast of San Luis province, Argentina. The affected Bt technologies were Herculex I® (HX-TC1507) and VT3PRO® (MON 89034 × MON 88017*). Event TC1507 expresses Cry1F and event MON 89034 expresses Cry1A.105 and Cry2Ab2, whichr are all Bt proteins with activity against the lepidopterans D. saccharalis and Spodoptera frugiperda (MON 88017 expresses the protein Cry3Bb1 for control of coleopteran insects and the enzyme CP4EPSPS for glyphosate tolerance). The affected area is an isolated region surrounded by sierra systems to the northeast and west, with a hot semi-arid climate, long frost-free period, warm winters, hot dry summers, and woody shrubs as native flora. To manage and mitigate the development of resistance, joint actions were taken by the industry, growers and Governmental Agencies. Hybrids expressing Vip3A protein (event MIR162) and/or Cry1Ab protein (events MON 810 and Bt11) as single or stacked events are used in early plantings to control the first generations of D. saccharalis, and in later plantings date's technologies with good control of S. frugiperda. A commitment was made to plant the refuge, and pest damage is monitored. As a result, maize production in the area is sustainable and profitable with yields above the average. PMID:29888224

The cost of karst subsidence and sinkhole collapse in the United States compared with other natural hazards

USGS Publications Warehouse

Weary, David J.

2015-01-01

Rocks with potential for karst formation are found in all 50 states. Damage due to karst subsidence and sinkhole collapse is a natural hazard of national scope. Repair of damage to buildings, highways, and other infrastructure represents a significant national cost. Sparse and incomplete data show that the average cost of karst-related damages in the United States over the last 15 years is estimated to be at least $300,000,000 per year and the actual total is probably much higher. This estimate is lower than the estimated annual costs for other natural hazards; flooding, hurricanes and cyclonic storms, tornadoes, landslides, earthquakes, or wildfires, all of which average over $1 billion per year. Very few state organizations track karst subsidence and sinkhole damage mitigation costs; none occurs at the Federal level. Many states discuss the karst hazard in their State hazard mitigation plans, but seldom include detailed reports of subsidence incidents or their mitigation costs. Most State highway departments do not differentiate karst subsidence or sinkhole collapse from other road repair costs. Amassing of these data would raise the estimated annual cost considerably. Information from insurance organizations about sinkhole damage claims and payouts is also not readily available. Currently there is no agency with a mandate for developing such data. If a more realistic estimate could be made, it would illuminate the national scope of this hazard and make comparison with costs of other natural hazards more realistic.

Overview of the Special Issue: A Multi-Model Framework to Achieve Consistent Evaluation of Climate Change Impacts in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waldhoff, Stephanie T.; Martinich, Jeremy; Sarofim, Marcus

2015-07-01

The Climate Change Impacts and Risk Analysis (CIRA) modeling exercise is a unique contribution to the scientific literature on climate change impacts, economic damages, and risk analysis that brings together multiple, national-scale models of impacts and damages in an integrated and consistent fashion to estimate climate change impacts, damages, and the benefits of greenhouse gas (GHG) mitigation actions in the United States. The CIRA project uses three consistent socioeconomic, emissions, and climate scenarios across all models to estimate the benefits of GHG mitigation policies: a Business As Usual (BAU) and two policy scenarios with radiative forcing (RF) stabilization targets ofmore » 4.5 W/m2 and 3.7 W/m2 in 2100. CIRA was also designed to specifically examine the sensitivity of results to uncertainties around climate sensitivity and differences in model structure. The goals of CIRA project are to 1) build a multi-model framework to produce estimates of multiple risks and impacts in the U.S., 2) determine to what degree risks and damages across sectors may be lowered from a BAU to policy scenarios, 3) evaluate key sources of uncertainty along the causal chain, and 4) provide information for multiple audiences and clearly communicate the risks and damages of climate change and the potential benefits of mitigation. This paper describes the motivations, goals, and design of the CIRA modeling exercise and introduces the subsequent papers in this special issue.« less

Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair

PubMed Central

Olszewska-Pazdrak, Barbara; McVicar, Scott D.; Rayavara, Kempaiah; Moya, Stephanie M.; Kantara, Carla; Gammarano, Chris; Olszewska, Paulina; Fuller, Gerald M.; Sower, Laurie E.; Carney, Darrell H.

2016-01-01

There is increasing evidence that radiation-induced damage to endothelial cells and loss of endothelial function may contribute to both acute radiation syndromes and long-term effects of whole-body nuclear irradiation. Therefore, several drugs are being developed to mitigate the effects of nuclear radiation, most of these drugs will target and protect or regenerate leukocytes and platelets. Our laboratory has demonstrated that TP508, a 23-amino acid thrombin peptide, activates endothelial cells and stem cells to revascularize and regenerate tissues. We now show that TP508 can mitigate radiation-induced damage to endothelial cells in vitro and in vivo. Our in vitro results demonstrate that human endothelial cells irradiation attenuates nitric oxide (NO) signaling, disrupts tube formation and induces DNA double-strand breaks (DSB). TP508 treatment reverses radiation effects on NO signaling, restores tube formation and accelerates the repair of radiation-induced DSB. The radiation-mitigating effects of TP508 on endothelial cells were also seen in CD-1 mice where systemic injection of TP508 stimulated endothelial cell sprouting from aortic explants after 8 Gy irradiation. Systemic doses of TP508 that mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice when injected 24 h after 8.5 Gy exposure. These data suggest that increased survival observed with TP508 treatment may be due to its effects on vascular and microvascular endothelial cells. Our study supports the usage of a regenerative drug such as TP508 to activate endothelial cells as a countermeasure for mitigating the effects of nuclear radiation. PMID:27388041

Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons.

PubMed

Manchon, Jose Felix Moruno; Dabaghian, Yuri; Uzor, Ndidi-Ese; Kesler, Shelli R; Wefel, Jeffrey S; Tsvetkov, Andrey S

2016-05-11

Neurotoxicity may occur in cancer patients and survivors during or after chemotherapy. Cognitive deficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory, attention, executive function and processing speed. Searching for pathways altered by anti-cancer treatments in cultured primary neurons, we discovered that doxorubicin, a commonly used anti-neoplastic drug, significantly decreased neuronal survival. The drug promoted the formation of DNA double-strand breaks in primary neurons and reduced synaptic and neurite density. Pretreatment of neurons with levetiracetam, an FDA-approved anti-epileptic drug, enhanced survival of chemotherapy drug-treated neurons, reduced doxorubicin-induced formation of DNA double-strand breaks, and mitigated synaptic and neurite loss. Thus, levetiracetam might be part of a valuable new approach for mitigating synaptic damage and, perhaps, for treating cognitive disturbances in cancer patients and survivors.

Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons

PubMed Central

Manchon, Jose Felix Moruno; Dabaghian, Yuri; Uzor, Ndidi-Ese; Kesler, Shelli R.; Wefel, Jeffrey S.; Tsvetkov, Andrey S.

2016-01-01

Neurotoxicity may occur in cancer patients and survivors during or after chemotherapy. Cognitive deficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory, attention, executive function and processing speed. Searching for pathways altered by anti-cancer treatments in cultured primary neurons, we discovered that doxorubicin, a commonly used anti-neoplastic drug, significantly decreased neuronal survival. The drug promoted the formation of DNA double-strand breaks in primary neurons and reduced synaptic and neurite density. Pretreatment of neurons with levetiracetam, an FDA-approved anti-epileptic drug, enhanced survival of chemotherapy drug-treated neurons, reduced doxorubicin-induced formation of DNA double-strand breaks, and mitigated synaptic and neurite loss. Thus, levetiracetam might be part of a valuable new approach for mitigating synaptic damage and, perhaps, for treating cognitive disturbances in cancer patients and survivors. PMID:27168474

Satellite data based method for general survey of forest insect disturbance in British Columbia

NASA Astrophysics Data System (ADS)

Ranson, J.; Montesano, P.

2008-12-01

Regional forest disturbances caused by insects are important to monitor and quantify because of their influence on local ecosystems and the global carbon cycle. Local damage to forest trees disrupts food supplies and shelter for a variety of organisms. Changes in the global carbon budget, its sources and its sinks affect the way the earth functions as a whole, and has an impact on global climate. Furthermore, the ability to detect nascent outbreaks and monitor the spread of regional infestations helps managers mitigate the damage done by catastrophic insect outbreaks. While detection is needed at a fine scale to support local mitigation efforts, detection at a broad regional scale is important for carbon flux modeling on the landscape scale, and needed to direct the local efforts. This paper presents a method for routinely detecting insect damage to coniferous forests using MODIS vegetation indices, thermal anomalies and land cover. The technique is validated using insect outbreak maps and accounts for fire disturbance effects. The range of damage detected may be used to interpret and quantify possible forest damage by insects.

Hypothermia can reverse hepatic oxidative stress damage induced by hypoxia in rats.

PubMed

Garnacho-Castaño, Manuel Vicente; Alva, Norma; Sánchez-Nuño, Sergio; Bardallo, Raquel G; Palomeque, Jesús; Carbonell, Teresa

2016-12-01

Our previous findings demonstrated that hypothermia enhances the reduction potential in the liver and helps to maintain the plasmatic antioxidant pool. Here, we aimed to elucidate if hypothermia protects against hypoxia-induced oxidative stress damage in rat liver. Several hepatic markers of oxidative stress were compared in three groups of animals (n = 8 in each group): control normothermic group ventilated with room air and two groups under extreme hypoxia (breathing 10 % O 2 ), one kept at normothermia (HN) (37 °C) and the other under deep hypothermia (HH) (central body temperature of 21-22 °C). Hypoxia in normothermia significantly increased the levels of hepatic nitric oxide, inducible nitric oxide synthase expression, protein oxidation, Carbonilated proteins, advanced oxidation protein products, 4-hydroxynonenal (HNE) protein adducts, and lipid peroxidation when compared to the control group (p < 0.05). However, when hypoxia was induced under hypothermia, results from the oxidative stress biomarker analyses did not differ significantly from those found in the control group. Indeed, 4-HNE protein adduct amounts were significantly lower in the HH versus HN group (p < 0.05). Therefore, hypothermia can mitigate hypoxia-induced oxidative stress damage in rat liver. These effects could help clarify the mechanisms of action of therapeutic hypothermia.

Predicting Hotspots of Human-Elephant Conflict to Inform Mitigation Strategies in Xishuangbanna, Southwest China.

PubMed

Chen, Ying; Marino, Jorgelina; Chen, Yong; Tao, Qing; Sullivan, Casey D; Shi, Kun; Macdonald, David W

2016-01-01

Research on the spatial patterns of human-wildlife conflict is fundamental to understanding the mechanisms underlying it and to identifying opportunities for mitigation. In the state of Xishuangbanna, containing China's largest tropical forest, an imbalance between nature conservation and economic development has led to increasing conflicts between humans and Asian elephants (Elephas maximus), as both elephant numbers and conversion of habitable land to rubber plantations have increased over the last several decades. We analyzed government data on the compensation costs of elephant-caused damage in Xishuangbanna between 2008 and 2012 to understand the spatial and temporal patterns of conflict, in terms of their occurrence, frequency and distribution. More than 18,261 incidents were reported, including episodes involving damage to rubber trees (n = 10,999), damage to crops such as paddy, upland rice, corn, bananas and sugarcane (n = 11,020), property loss (n = 689) and attacks on humans (n = 19). The conflict data reconfirmed the presence of elephants in areas which have lacked records since the late 1990s. Zero Altered Negative Binomial models revealed that the risk of damage to crops and plantations increased with proximity to protected areas, increasing distance from roads, and lower settlement density. The patterns were constant across seasons and types of crop damaged. Damage to rubber trees was essentially incidental as elephants searched for crops to eat. A predictive map of risks revealed hotspots of conflict within and around protected areas, the last refuges for elephants in the region, and along habitat corridors connecting them. Additionally, we analyzed how mitigation efforts can best diminish the risk of conflict while minimizing financial costs and adverse biological impacts. Our analytical approach can be adopted, adjusted and expanded to other areas with historical records of human-wildlife conflict.

Protected areas mitigate diseases of reef-building corals by reducing damage from fishing.

PubMed

Lamb, Joleah B; Williamson, David H; Russ, Garry R; Willis, Bette L

2015-09-01

Parks and protected areas have been instrumental in reducing anthropogenic sources of damage in terrestrial and aquatic environments. Pathogen invasion often succeeds physical wounding and injury, yet links between the reduction of damage and the moderation of disease have not been assessed. Here, we examine the utility of no-take marine reserves as tools for mitigating diseases that affect reef-building corals. We found that sites located within reserves had fourfold reductions in coral disease prevalence compared to non-reserve sites (80466 corals surveyed). Of 31 explanatory variables assessed, coral damage and the abundance of derelict fishing line best explained differences in disease assemblages between reserves and non-reserves. Unexpectedly, we recorded significantly higher levels of disease, coral damage, and derelict fishing line in non-reserves with fishing gear restrictions than in those without gear restrictions. Fishers targeting stocks perceived to be less depleted, coupled with enhanced site access from immediately adjacent boat moorings, may explain these unexpected patterns. Significant correlations between the distance from mooring sites and prevalence values for a ciliate disease known to infest wounded tissue (r = -0.65), coral damage (r = -0.64), and the abundance of derelict fishing line (r = -0.85) corroborate this interpretation. This is the first study to link disease with recreational use intensity in a park, emphasizing the need to evaluate the placement of closures and their direct relationship to ecosystem health. Since corals are modular, ecological processes that govern reproductive and competitive fitness are frequently related to colony surface area therefore, even low levels of cumulative tissue loss from progressing diseases pose significant threats to reef coral persistence. Disease mitigation through reductions in physical injury in areas where human activities are concentrated is another mechanism by which protected areas may improve ecosystem resilience in a changing climate.

Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats.

PubMed

Mahmood, J; Jelveh, S; Zaidi, A; Doctrow, S R; Hill, R P

2013-02-01

Exposure of civilian populations to radiation due to accident, war or terrorist act is an increasing concern. The lung is one of the more radiosensitive organs that may be affected in people receiving partial-body irradiation and radiation injury in lung is thought to be associated with the development of a prolonged inflammatory response. Here we examined how effectively damage to the lung can be mitigated by administration of drugs initiated at different times after radiation exposure and examined response in adolescent animals for comparison with the young adult animals that we had studied previously. We studied the mitigation efficacy of the isoflavone genistein (50 mg/kg) and the salen-Mn superoxide dismutase-catalase mimetic EUK-207 (8 mg/kg), both of which have been reported to scavenge reactive oxygen species and reduce activity of the NFkB pathway. The drugs were given by subcutaneous injection to 6- to 7-week-old Fisher rats daily starting either immediately or 2 weeks after irradiation with 12 Gy to the whole thorax. The treatment was stopped at 28 weeks post irradiation and the animals were assessed for levels of inflammatory cytokines, activated macrophages, oxidative damage and fibrosis at 48 weeks post irradiation. We demonstrated that both genistein and EUK-207 delayed and suppressed the increased breathing rate associated with pneumonitis. These agents also reduced levels of oxidative damage (50-100%), levels of TGF-β1 expression (75-100%), activated macrophages (20-60%) and fibrosis (60-80%). The adolescent rats developed pneumonitis earlier following irradiation of the lung than did the adult rats leading to greater severe morbidity requiring euthanasia (∼37% in adolescents vs. ∼10% in young adults) but the extent of the mitigation of the damage was similar or slightly greater.

Targeting the Renin–Angiotensin System Combined With an Antioxidant Is Highly Effective in Mitigating Radiation-Induced Lung Damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahmood, Javed; Radiation Medicine Program, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario; Jelveh, Salomeh

Purpose: To investigate the outcome of suppression of the renin angiotensin system using captopril combined with an antioxidant (Eukarion [EUK]-207) for mitigation of radiation-induced lung damage in rats. Methods and Materials: The thoracic cavity of female Sprague-Dawley rats was irradiated with a single dose of 11 Gy. Treatment with captopril at a dose of 40 mg/kg/d in drinking water and EUK-207 given by subcutaneous injection (8 mg/kg daily) was started 1 week after irradiation (PI) and continuing until 14 weeks PI. Breathing rate was monitored until the rats were killed at 32 weeks PI, when lung fibrosis was assessed by lung hydroxyproline content. Lung levels ofmore » the cytokine transforming growth factor-β1 and macrophage activation were analyzed by immunohistochemistry. Oxidative DNA damage was assessed by 8-hydroxy-2-deoxyguanosine levels, and lipid peroxidation was measured by a T-BARS assay. Results: The increase in breathing rate in the irradiated rats was significantly reduced by the drug treatments. The drug treatment also significantly decreased the hydroxyproline content, 8-hydroxy-2-deoxyguanosine and malondialdehyde levels, and levels of activated macrophages and the cytokine transforming growth factor-β1 at 32 weeks. Almost complete mitigation of these radiation effects was observed by combining captopril and EUK-207. Conclusion: Captopril and EUK-207 can provide mitigation of radiation-induced lung damage out to at least 32 weeks PI after treatment given 1-14 weeks PI. Overall the combination of captopril and EUK-207 was more effective than the individual drugs used alone.« less

DARPA challenge: developing new technologies for brain and spinal injuries

NASA Astrophysics Data System (ADS)

Macedonia, Christian; Zamisch, Monica; Judy, Jack; Ling, Geoffrey

2012-06-01

The repair of traumatic injuries to the central nervous system remains among the most challenging and exciting frontiers in medicine. In both traumatic brain injury and spinal cord injuries, the ultimate goals are to minimize damage and foster recovery. Numerous DARPA initiatives are in progress to meet these goals. The PREventing Violent Explosive Neurologic Trauma program focuses on the characterization of non-penetrating brain injuries resulting from explosive blast, devising predictive models and test platforms, and creating strategies for mitigation and treatment. To this end, animal models of blast induced brain injury are being established, including swine and non-human primates. Assessment of brain injury in blast injured humans will provide invaluable information on brain injury associated motor and cognitive dysfunctions. The Blast Gauge effort provided a device to measure warfighter's blast exposures which will contribute to diagnosing the level of brain injury. The program Cavitation as a Damage Mechanism for Traumatic Brain Injury from Explosive Blast developed mathematical models that predict stresses, strains, and cavitation induced from blast exposures, and is devising mitigation technologies to eliminate injuries resulting from cavitation. The Revolutionizing Prosthetics program is developing an avant-garde prosthetic arm that responds to direct neural control and provides sensory feedback through electrical stimulation. The Reliable Neural-Interface Technology effort will devise technologies to optimally extract information from the nervous system to control next generation prosthetic devices with high fidelity. The emerging knowledge and technologies arising from these DARPA programs will significantly improve the treatment of brain and spinal cord injured patients.

Comparison of Aerobic Preservation by Venous Systemic Oxygen Persufflation or Oxygenated Machine Perfusion of Warm-Ischemia-Damaged Porcine Kidneys.

PubMed

Kalenski, Julia; Mancina, Elina; Paschenda, Pascal; Beckers, Christian; Bleilevens, Christian; Tóthová, Ľubomíra; Boor, Peter; Gross, Dominik; Tolba, René H; Doorschodt, Benedict M

2016-01-01

The global shortage of donor organs for transplantation has necessitated the expansion of the organ pool through increased use of organs from less ideal donors. Venous systemic oxygen persufflation (VSOP) and oxygenated machine perfusion (OMP) have previously demonstrated beneficial results compared to cold storage (CS) in the preservation of warm-ischemia-damaged kidney grafts. The aim of this study was to compare the efficacy of VSOP and OMP for the preservation of warm-ischemia-damaged porcine kidneys using the recently introduced Ecosol preservation solution compared to CS using Ecosol or histidine-tryptophan-ketoglutarate solution (HTK). Kidneys from German Landrace pigs (n = 5/group) were retrieved and washed out with either Ecosol or HTK after 45 min of clamping of the renal pedicle. As controls, kidneys without warm ischemia, cold stored for 24 h in HTK, were employed. Following 24 h of preservation by VSOP, OMP, CS-Ecosol, or CS-HTK, renal function and damage were assessed during 1 h using the isolated perfused porcine kidney model. During reperfusion, urine production was significantly higher in the VSOP and OMP groups than in the CS-HTK group; however, only VSOP could demonstrate lower urine protein concentrations and fractional excretion of sodium, which did not differ from the non-warm-ischemia-damaged control group. VSOP, CS-Ecosol, and controls showed better maintenance of the acid-base balance than CS-HTK. Reduced lipid peroxidation, as reflected in postreperfusion tissue thiobarbituric acid-reactive substance levels, was observed in the VSOP group compared to the OMP group, and the VSOP and CS-Ecosol groups had concentrations similar to the controls. The ratio of reduced to oxidized glutathione was higher in the VSOP, OMP, and CS-Ecosol groups than in the CS-HTK group and controls, with a higher ratio in the VSOP than in the OMP group. VSOP was associated with mitigation of oxidative stress in comparison to OMP and CS. Preservation of warm-ischemia-damaged porcine kidneys by VSOP was improved compared to OMP and CS, and was comparable to preservation of non-warm-ischemia-damaged cold-stored kidneys. © 2016 S. Karger AG, Basel.

Edaravone, a Free Radical Scavenger, Mitigates Both Gray and White Matter Damages after Global Cerebral Ischemia in Rats

PubMed Central

Kubo, Kozue; Nakao, Shinichi; Jomura, Sachiko; Sakamoto, Sachiyo; Miyamoto, Etsuko; Xu, Yan; Tomimoto, Hidekazu; Inada, Takefumi; Shingu, Koh

2012-01-01

Recent studies have shown that similar to cerebral gray matter (mainly composed of neuronal perikarya), white matter (composed of axons and glias) is vulnerable to ischemia. Edaravone, a free radical scavenger, has neuroprotective effects against focal cerebral ischemia even in humans. In this study, we investigated the time course and the severity of both gray and white matter damage following global cerebral ischemia by cardiac arrest, and examined whether edaravone protected the gray and the white matter. Male Sprague-Dawley rats were used. Global cerebral ischemia was induced by 5 minutes of cardiac arrest and resuscitation (CAR). Edaravone, 3 mg/kg, was administered intravenously either immediately or 60 minutes after CAR. The morphological damage was assessed by cresyl violet staining. The microtubule-associated protein 2 (a maker of neuronal perikarya and dendrites), the β amyloid precursor protein (the accumulation of which is a maker of axonal damage), and the ionized calcium binding adaptor molecule 1 (a marker of microglia) were stained for immunohistochemical analysis. Significant neuronal perikaryal damage and marked microglial activation were observed in the hippocampal CA1 region with little axonal damage one week after CAR. Two weeks after CAR, the perikaryal damage and microglial activation were unchanged, but obvious axonal damage occurred. Administration of edaravone 60 minutes after CAR significantly mitigated the perikaryal damage, the axonal damage, and the microglial activation. Our results show that axonal damage develops slower than perikaryal damage and that edaravone can protect both gray and white matter after CAR in rats. PMID:19410562

Effects of various asphalt binder additives/modifiers on moisture susceptible asphaltic mixtures.

DOT National Transportation Integrated Search

2014-01-01

Moisture damage of asphalt concrete is defined as the loss of strength and stability caused by the active presence of : moisture. The most common technique to mitigate moisture damage is using additives or modifiers with the asphalt binder or : the a...

78 FR 13844 - Change in Submission Requirements for State Mitigation Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... protecting human lives and the environment. No action that FEMA can anticipate under this rule will have a... to reduce damage to lives, property, and the economy from future disasters. State, Tribal, and local... funding for eligible mitigation activities that reduce disaster losses and protect life and property from...

13 CFR 123.204 - How much can your business borrow for post-disaster mitigation?

Code of Federal Regulations, 2010 CFR

2010-01-01

... for post-disaster mitigation? 123.204 Section 123.204 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Physical Disaster Business Loans § 123.204 How much can your business borrow... approved physical disaster business loan to repair or replace your damaged business real estate and other...

Mitigating intrinsic defects and laser damage using pulsetrain-burst (>100 MHz) ultrafast laser processing

NASA Astrophysics Data System (ADS)

McKinney, Luke; Frank, Felix; Graper, David; Dean, Jesse; Forrester, Paul; Rioblanc, Maxence; Nantel, Marc; Marjoribanks, Robin

2005-09-01

Ultrafast-laser micromachining has promise as an approach to trimming and 'healing' small laser-produced damage sites in laser-system optics--a common experience in state-of-the-art high-power laser systems. More-conventional approaches currently include mechanical micromachining, chemical modification, and treatment using cw and long-pulse lasers. Laser-optics materials of interest include fused silica, multilayer dielectric stacks for anti-reflection coatings or high-reflectivity mirrors, and inorganic crystals such as KD*P, used for Pockels cells and frequency-doubling. We report on novel efforts using ultrafast-laser pulsetrain-burst processing (microsecond bursts at 133 MHz) to mitigate damage in fused silica, dielectric coatings, and KD*P crystals. We have established the characteristics of pulsetrain-burst micromachining in fused silica, multilayer mirrors, and KD*P, and determined the etch rates and morphology under different conditions of fluence-delivery. From all of these, we have begun to identify new means to optimize the laser-repair of optics defects and damage.

Recent progress and application on seismic isolation energy dissipation and control for structures in China

NASA Astrophysics Data System (ADS)

Zhou, Fulin; Tan, Ping

2018-01-01

China is a country where 100% of the territory is located in a seismic zone. Most of the strong earthquakes are over prediction. Most fatalities are caused by structural collapse. Earthquakes not only cause severe damage to structures, but can also damage non-structural elements on and inside of facilities. This can halt city life, and disrupt hospitals, airports, bridges, power plants, and other infrastructure. Designers need to use new techniques to protect structures and facilities inside. Isolation, energy dissipation and, control systems are more and more widely used in recent years in China. Currently, there are nearly 6,500 structures with isolation and about 3,000 structures with passive energy dissipation or hybrid control in China. The mitigation techniques are applied to structures like residential buildings, large or complex structures, bridges, underwater tunnels, historical or cultural relic sites, and industrial facilities, and are used for retrofitting of existed structures. This paper introduces design rules and some new and innovative devices for seismic isolation, energy dissipation and hybrid control for civil and industrial structures. This paper also discusses the development trends for seismic resistance, seismic isolation, passive and active control techniques for the future in China and in the world.

Mitigation of Subsynchronous Resonance with Fractional-order PI based UPFC controller

NASA Astrophysics Data System (ADS)

Raju, D. Koteswara; Umre, Bhimrao S.; Junghare, Anjali S.; Babu, B. Chitti

2017-02-01

Due to incorporation of series capacitor compensation in transmission line for stability improvement, subsynchronous oscillations are generated at turbine-generator shaft. These oscillations can damage the shaft system if these are not well suppressed. In order to damp out these oscillations, usually power system network should have sufficient damping and the increase of network damping is obtained by the injection of subsynchronous component of voltage and current into the line, which are extracted from the measured signal of the system. However, the effectiveness of damp out of these subsynchronous oscillations is possibly by incorporating UPFC in the transmission line network is of high interest and it should be further investigated. This research article proposes the mitigation of subsynchronous resonance (SSR) using fractional-order PI (FOPI) based unified power flow controller (UPFC). The robustness of the proposed controller is tested for 25%, 55% and 70% series compensation with a symmetrical fault (L-L-L fault). Further, Eigenvalue analysis and Fast Fourier Transform (FFT) analysis against operating point variations and uncertainties in the system are also examined. The IEEE first benchmark model is adopted for this study and the superiority of the FOPI based UPFC controller over PI based UPFC controller is discussed by comparing the results with various performance indices.

Vitamins A, C, and E may reduce intestinal Po-210 levels after ingestion

PubMed Central

Kemp, Francis W; Portugal, Frank; Akudugu, John M.; Neti, Prasad VSV; Ferraris, Ronaldo P.; Howell, Roger W.

2016-01-01

Damage to the gut mucosa is a probable contributory cause of death from ingested 210Po. Therefore, medical products are needed that can prevent, mitigate, and/or repair gastrointestinal (GI) damage caused by high-LET radiation emitted by 210Po. The present studies investigated the capacity of a diet highly enriched with vitamins A, C, and E (vitamin ACE) to protect against intestinal mucosal damage indicated by functional reductions in nutrient transport caused by orally ingested 210Po. Mice were gavaged with 0 or 18.5 kBq 210Po-citrate and fed a control or vitamin ACE-enriched diet (the latter beginning either 96 h before or immediately after gavage). Mouse intestines significantly retained 210Po on day 8 post-gavage. The concentration of 210Po in intestinal tissues was significantly (p<0.05) lower in all vitamin ACE groups compared to control. There were borderline significant 210Po-induced reductions in intestinal absorption of D-fructose. The combination of vitamins A, C, and E may reduce 210Po incorporation in the intestines when given before, or enhance decorporation when provided after, 210Po gavage. PMID:27218295

Fish and Wildlife Mitigation: An Introductory Analysis of the Concept and its Importance in the Management of Estuarine Resources,

DTIC Science & Technology

1980-12-01

Ken Brunner who all provided valuable conceptual information, and to Ted LaRoe of the Interior Department who originally sparked my interest in...This concept has led, in large part, to the management theory that damage to the ecosystem in one area can be mitigated by constructive or restora...In accordance with the ecosystem theory , it may be possible to mitigate project-specific impacts by emphasizing replacement and maintenance of

Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.

PubMed

Ock, Chan Young; Park, Jong-Min; Han, Young-Min; Jeong, Migyeong; Kim, Mi-Young; Lee, Ho Jae; Hahm, Ki Baik

2017-04-01

Non-steroidal anti-inflammatory drug (NSAID)-associated endoplasmic reticulum (ER) stress (a cyclooxygenase-2-independent mechanism) and consequent autophagic cell death are responsible for NSAID-associated gastric damage. Therefore, alleviating cytotoxicity executed via ER stress and autophagy can be a strategy to prevent NSAID-associated gastric damage. Here, we explored whether genetic or pharmacologic inhibition of autophagy can mitigate NSAID-associated gastric damage in in vitro and in vivo models. To examine the effects of genetic inhibition of NSAID-associated autophagy, we administered indomethacin to RGM1 gastric mucosal cells transfected with shPERK, siLC3B, or shATG5 and microtubule-associated protein light chain 3B knock-out (LC3B -/- ) mice. 3-Methyladenine (3-MA) or chloroquine (CQ) was used for pharmacologic inhibition of autophagy in both models. Indomethacin administration increased the expression of ER stress proteins including GRP78, ATF6, and CHOP. Indomethacin provoked the appearance of autophagic vesicles with the increased expression of ATG5 and LC3B-II. Genetic ablation of various ER stress genes significantly attenuated indomethacin-induced autophagy and apoptosis (p < 0.01), whereas knock-down of either ATG5 or LC3B significantly reduced indomethacin-induced cytotoxicity (p < 0.01). Testing each of the genes implicated in ER stress and autophagy showed that indomethacin leads to gastric cell apoptosis through autophagy induction consequent to ER stress. Pharmacological inhibition of autophagy with either 3-MA or CQ in rats or genetic ablation of LC3B in mice all had a significant rescuing effect against indomethacin-associated gastric damage (p < 0.01) and a decrease in molecular markers of autophagic and apoptotic gastric cells. In conclusion, preemptive autophagy inhibition can be a potential strategy to mitigate NSAID-associated gastric damage. NSAID administration triggered ER stress and subsequent autophagy. Inhibition of autophagy resulted in attenuated NSAID-associated cytotoxicity. Autophagy inhibitors represent a novel strategy to prevent NSAID-associated gastric damage.

Testing GIC Mitigation Protocols by Modelling Transformer-Level GIC Flow in New Zealand's Electrical Transmission Grid

NASA Astrophysics Data System (ADS)

Divett, T.; Ingham, M.; Rodger, C. J.; Richardson, G. S.; Beggan, C.; Thomson, A. W. P.; Dalzell, M.; Mac Manus, D. H.

2017-12-01

Transformers in the South Island of Transpower New Zealand Ltd's electrical transmission network have been impacted by geomagnetically induced currents (GIC) during geomagnetic storms, including the November 2001 event. We aim to make recommendations that lead to improving mitigation strategies for reducing these impacts during extreme events. We have adapted a thin-sheet electromagnetic and GIC network modelling approach that has previously been successfully used in the UK to New Zealand's geology and transmission network. In this presentation we show how we have used this approach to explore Transpower's mitigation procedure as well as alternative mitigation options for reducing the impact of space weather on the network. In order to compare modelled GIC with what has been described as `possibly the best GIC dataset in the world' (Boteler and Pirjola, Pers. Comm. 2016) our model includes every transformer and every high voltage transmission line in the South Island network. This level of detail was required to match the transformer level observations of GIC in the network and to appropriately assess the mitigation options at the level where the damage to power networks occurs. We found that removing a single generator at a central power station and four transmission lines is enough to effectively redistribute GIC away from transformers that have previously experienced very high GIC (as shown in Figure). The redistributed GIC is less damaging to the transformers that it is redistributed to due to lower total GIC at those locations. In the past the impact of GIC on transformers has occurred in the first two minutes of a storm. Hence, mitigation strategies that currently rely on human intervention and involving delays of up to 15 minutes may need to be initiated very rapidly, in a significant departure from Transpower's existing protocol. Reducing delays should significantly reduce the potential for damage in a storm equivalent to the 2001 event. During an extreme storm we expect GIC of 300 A or more to flow through multiple transformers across both islands. In the case of an extreme storm we suggest the more drastic approach of floating the entire network to reduce the potential for damage while retaining power supply to the majority of the country.

Toward to Disaster Mitigation Science

NASA Astrophysics Data System (ADS)

Kaneda, Yoshiyuki; Shiraki, Wataru; Tokozakura, Eiji

2016-04-01

Destructive natural disasters such as earthquakes and tsunamis have occurred frequently in the world. For the reduction and mitigation of damages by destructive natural disasters, early detection of natural disasters and speedy and proper evacuations are indispensable. And hardware and software preparations for reduction and mitigation of natural disasters are quite important and significant. Finally, methods on restorations and revivals are necessary after natural disasters. We would like to propose natural disaster mitigation science for early detections, evacuations and restorations against destructive natural disasters. In natural disaster mitigation science, there are lots of research fields such as natural science, engineering, medical treatment, social science and literature/art etc. Especially, natural science, engineering and medical treatment are fundamental research fields for natural disaster mitigation, but social sciences such as sociology, psychology etc. are very important research fields for restorations after natural disasters. We have to progress the natural disaster mitigation science against destructive natural disaster mitigation. in the near future. We will present the details of natural disaster mitigation science.

Genesis Contingency Planning and Mishap Recovery: The Sample Curation View

NASA Technical Reports Server (NTRS)

Stansbery, E. K.; Allton, J. H.; Allen, C. C.; McNamara, K. M.; Calaway, M.; Rodriques, M. C.

2007-01-01

Planning for sample preservation and curation was part of mission design from the beginning. One of the scientific objectives for Genesis included collecting samples of three regimes of the solar wind in addition to collecting bulk solar wind during the mission. Collectors were fabricated in different thicknesses for each regime of the solar wind and attached to separate frames exposed to the solar wind during specific periods of solar activity associated with each regime. The original plan to determine the solar regime sampled for specific collectors was to identify to which frame the collector was attached. However, the collectors were dislodged during the hard landing making identification by frame attachment impossible. Because regimes were also identified by thickness of the collector, the regime sampled is identified by measuring fragment thickness. A variety of collector materials and thin films applied to substrates were selected and qualified for flight. This diversity provided elemental measurement in more than one material, mitigating effects of diffusion rates and/or radiation damage. It also mitigated against different material and substrate strengths resulting in differing effects of the hard landing. For example, silicon crystal substrates broke into smaller fragments than sapphire-based substrates and diamond surfaces were more resilient to flying debris damage than gold. The primary responsibility of the curation team for recovery was process documentation. Contingency planning for the recovery phase expanded this responsibility to include not only equipment to document, but also gather, contain and identify samples from the landing area and the recovered spacecraft. The team developed contingency plans for various scenarios as part of mission planning that included topographic maps to aid in site recovery and identification of different modes of transport and purge capability depending on damage. A clean tent, set-up at Utah Test & Training Range to control the environment for processing the sample return capsule and cleanly installing a nitrogen purge to the canister, was used to control the environment for extracting collector fragments from the damaged canister and to document and package over 10,000 collector fragments.

Does seeding after wildfires in rangelands reduce erosion or invasive species?

Treesearch

David A. Pyke; Troy A. Wirth; Jan L. Beyers

2013-01-01

Mitigation of ecological damage caused by rangeland wildfires has historically been an issue restricted to the western United States. It has focused on conservation of ecosystem function through reducing soil erosion and spread of invasive plants. Effectiveness of mitigation treatments has been debated recently. We reviewed recent literature to conduct a meta-analysis...

13 CFR 123.107 - How much can I borrow for post-disaster mitigation for my home?

Code of Federal Regulations, 2010 CFR

2010-01-01

...-disaster mitigation for my home? 123.107 Section 123.107 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.107 How much can I borrow for post-disaster... disaster loan to repair or replace your damaged primary residence and personal property. [67 FR 62337, Oct...

Life-Extending Control for Aircraft Engines Studied

NASA Technical Reports Server (NTRS)

Guo, Te-Huei

2002-01-01

Current aircraft engine controllers are designed and operated to provide both performance and stability margins. However, the standard method of operation results in significant wear and tear on the engine and negatively affects the on-wing life--the time between cycles when the engine must be physically removed from the aircraft for maintenance. The NASA Glenn Research Center and its industrial and academic partners have been working together toward a new control concept that will include engine life usage as part of the control function. The resulting controller will be able to significantly extend the engine's on-wing life with little or no impact on engine performance and operability. The new controller design will utilize damage models to estimate and mitigate the rate and overall accumulation of damage to critical engine parts. The control methods will also provide a means to assess tradeoffs between performance and structural durability on the basis of mission requirements and remaining engine life. Two life-extending control methodologies were studied to reduce the overall life-cycle cost of aircraft engines. The first methodology is to modify the baseline control logic to reduce the thermomechanical fatigue (TMF) damage of cooled stators during acceleration. To accomplish this, an innovative algorithm limits the low-speed rotor acceleration command when the engine has reached a threshold close to the requested thrust. This algorithm allows a significant reduction in TMF damage with only a very small increase in the rise time to reach the commanded rotor speed. The second methodology is to reduce stress rupture/creep damage to turbine blades and uncooled stators by incorporating an engine damage model into the flight mission. Overall operation cost is reduced by an optimization among the flight time, fuel consumption, and component damages. Recent efforts have focused on applying life-extending control technology to an existing commercial turbine engine, and doing so without modifying the hardware or adding sensors. This approach makes it possible to retrofit existing engines with life-extending control technology by changing only the control software in the full-authority digital engine controller (FADEC). The significant results include demonstrating a 20- to 30-percent reduction in TMF damage to the hot section by developing and implementing smart acceleration logic during takeoff. The tradeoff is an increase, from 5.0 to 5.2 sec, in the time required to reach maximum power from ground idle. On a typical flight profile of a cruise at Mach 0.8 at an altitude of 41,000 ft, and cruise time of 104 min, the optimized system showed that a reduction in cruise speed from Mach 0.8 to 0.79 can achieve an estimated 25-to 35-percent creep/rupture damage reduction in the engine's hot section and a fuel savings of 2.1 percent. The tradeoff is an increase in flight time of 1.3 percent (1.4 min).

Disaster management and mitigation: the telecommunications infrastructure.

PubMed

Patricelli, Frédéric; Beakley, James E; Carnevale, Angelo; Tarabochia, Marcello; von Lubitz, Dag K J E

2009-03-01

Among the most typical consequences of disasters is the near or complete collapse of terrestrial telecommunications infrastructures (especially the distribution network--the 'last mile') and their concomitant unavailability to the rescuers and the higher echelons of mitigation teams. Even when such damage does not take place, the communications overload/congestion resulting from significantly elevated traffic generated by affected residents can be highly disturbing. The paper proposes innovative remedies to the telecommunications difficulties in disaster struck regions. The offered solutions are network-centric operations-cap able, and can be employed in management of disasters of any magnitude (local to national or international). Their implementation provide ground rescue teams (such as law enforcement, firemen, healthcare personnel, civilian authorities) with tactical connectivity among themselves, and, through the Next Generation Network backbone, ensure the essential bidirectional free flow of information and distribution of Actionable Knowledge among ground units, command/control centres, and civilian and military agencies participating in the rescue effort.

Scrotal insulation and sperm production in the boar.

PubMed

Parrish, John J; Willenburg, Kilby L; Gibbs, Katelynn M; Yagoda, Kylie B; Krautkramer, Megan M; Loether, Teyanna M; Melo, Fabiana C S A

2017-09-01

Seasonal infertility is a limiting factor in boar fertility, and is increasingly important as climate changes. Spermatogenesis in the boar produces 256 spermatozoa per type A 1 spermatogonium, but the process is inefficient such that only 10-30% of these potential spermatozoa are actually produced. Heat further impacts spermatogenesis by reducing the number of specific germ cells produced while increasing the fraction of abnormal sperm. Early studies used whole-animal exposure to simulate seasonal exposure to heat under production settings, but this approach is associated with many confounding factors that make assessment of the mechanisms of heat-induced damage to spermatogenesis difficult. Scrotal insulation provides a better model to investigate the mechanisms and potential mitigation strategies of heat-induce damage. For example, scrotal insulation helped identify a link between short-term heat stress and damage to meiotic germ cells. This outcome is likely due to changes in the integrity of the blood-testis barrier, which induce apoptosis, autophagy and DNA damage in the germ cells. Further understanding how heat damages spermatogenesis, and whether or not this can be repaired, are crucial to mitigating heat effects on boars in production settings. © 2017 Wiley Periodicals, Inc.

Role of tool marks inside spherical mitigation pit fabricated by micro-milling on repairing quality of damaged KH2PO4 crystal

PubMed Central

Chen, Ming-Jun; Cheng, Jian; Yuan, Xiao-Dong; Liao, Wei; Wang, Hai-Jun; Wang, Jing-He; Xiao, Yong; Li, Ming-Quan

2015-01-01

Repairing initial slight damage site into stable structures by engineering techniques is the leading strategy to mitigate the damage growth on large-size components used in laser-driven fusion facilities. For KH2PO4 crystals, serving as frequency converter and optoelectronic switch-Pockels cell, micro-milling has been proven the most promising method to fabricate these stable structures. However, tool marks inside repairing pit would be unavoidably introduced due to the wearing of milling cutter in actual repairing process. Here we quantitatively investigate the effect of tool marks on repairing quality of damaged crystal components by simulating its induced light intensification and testing the laser-induced damage threshold. We found that due to the formation of focusing hot spots and interference ripples, the light intensity is strongly enhanced with the presence of tool marks, especially for those on rear surfaces. Besides, the negative effect of tool marks is mark density dependent and multiple tool marks would aggravate the light intensification. Laser damage tests verified the role of tool marks as weak points, reducing the repairing quality. This work offers new criterion to comprehensively evaluate the quality of repaired optical surfaces to alleviate the bottleneck issue of low laser damage threshold for optical components in laser-driven fusion facilities. PMID:26399624

Structural control and health monitoring of building structures with unknown ground excitations: Experimental investigation

NASA Astrophysics Data System (ADS)

He, Jia; Xu, You-Lin; Zhan, Sheng; Huang, Qin

2017-03-01

When health monitoring system and vibration control system both are required for a building structure, it will be beneficial and cost-effective to integrate these two systems together for creating a smart building structure. Recently, on the basis of extended Kalman filter (EKF), a time-domain integrated approach was proposed for the identification of structural parameters of the controlled buildings with unknown ground excitations. The identified physical parameters and structural state vectors were then utilized to determine the control force for vibration suppression. In this paper, the possibility of establishing such a smart building structure with the function of simultaneous damage detection and vibration suppression was explored experimentally. A five-story shear building structure equipped with three magneto-rheological (MR) dampers was built. Four additional columns were added to the building model, and several damage scenarios were then simulated by symmetrically cutting off these columns in certain stories. Two sets of earthquakes, i.e. Kobe earthquake and Northridge earthquake, were considered as seismic input and assumed to be unknown during the tests. The structural parameters and the unknown ground excitations were identified during the tests by using the proposed identification method with the measured control forces. Based on the identified structural parameters and system states, a switching control law was employed to adjust the current applied to the MR dampers for the purpose of vibration attenuation. The experimental results show that the presented approach is capable of satisfactorily identifying structural damages and unknown excitations on one hand and significantly mitigating the structural vibration on the other hand.

Radiation damage to nucleoprotein complexes in macromolecular crystallography

DOE PAGES

Bury, Charles; Garman, Elspeth F.; Ginn, Helen Mary; ...

2015-01-30

Significant progress has been made in macromolecular crystallography over recent years in both the understanding and mitigation of X-ray induced radiation damage when collecting diffraction data from crystalline proteins. Despite the large field that is productively engaged in the study of radiation chemistry of nucleic acids, particularly of DNA, there are currently very few X-ray crystallographic studies on radiation damage mechanisms in nucleic acids. Quantitative comparison of damage to protein and DNA crystals separately is challenging, but many of the issues are circumvented by studying pre-formed biological nucleoprotein complexes where direct comparison of each component can be made under themore » same controlled conditions. A model protein–DNA complex C.Esp1396I is employed to investigate specific damage mechanisms for protein and DNA in a biologically relevant complex over a large dose range (2.07–44.63 MGy). In order to allow a quantitative analysis of radiation damage sites from a complex series of macromolecular diffraction data, a computational method has been developed that is generally applicable to the field. Typical specific damage was observed for both the protein on particular amino acids and for the DNA on, for example, the cleavage of base-sugar N 1—C and sugar-phosphate C—O bonds. Strikingly the DNA component was determined to be far more resistant to specific damage than the protein for the investigated dose range. We observed the protein at low doses and found that they were susceptible to radiation damage while the DNA was far more resistant, damage only being observed at significantly higher doses.« less

Climate mitigation: sustainable preferences and cumulative carbon

NASA Astrophysics Data System (ADS)

Buckle, Simon

2010-05-01

We develop a stylized AK growth model with both climate damages to ecosystem goods and services and sustainable preferences that allow trade-offs between present discounted utility and long-run climate damages. The simplicity of the model permits analytical solutions. Concern for the long-term provides a strong driver for mitigation action. One plausible specification of sustainable preferences leads to the result that, for a range of initial parameter values, an optimizing agent would choose a level of cumulative carbon dioxide (CO2) emissions independent of initial production capital endowment and CO2 levels. There is no technological change so, for economies with sufficiently high initial capital and CO2 endowments, optimal mitigation will lead to disinvestment. For lower values of initial capital and/or CO2 levels, positive investment can be optimal, but still within the same overall level of cumulative emissions. One striking aspect of the model is the complexity of possible outcomes, in addition to these optimal solutions. We also identify a resource constrained region and several regions where climate damages exceed resources available for consumption. Other specifications of sustainable preferences are discussed, as is the case of a hard constraint on long-run damages. Scientists are currently highlighting the potential importance of the cumulative carbon emissions concept as a robust yet flexible target for climate policymakers. This paper shows that it also has an ethical interpretation: it embodies an implicit trade off in global welfare between present discounted welfare and long-term climate damages. We hope that further development of the ideas presented here might contribute to the research and policy debate on the critical areas of intra- and intergenerational welfare.

The Abudance Of Makrozoobenthos On Different Break Water In Semarang And Demak Coastal Area

NASA Astrophysics Data System (ADS)

Kristiningsih, A.; Sugianto, D. N.; Munasik; Pribadi, R.; Suprijanto, J.

2018-02-01

The coast of Semarang and Demak has suffered some damage to its coastal areas. This damage is caused by natural factors and also human activities. There are number of mitigation methods such as hard, soft and hybrid that available for mitigation erosion. In Semarang and Demak coastal area using hard and hybrid option as their mitigation erotion. Breakwater is one of the way beach structure that often used as mitigation erosion di coastal area. Breakwater will cause sediment deposits that will become the living place of various organisms such as makrozoobenthos. The aim of this research is compare the abudance of makrozoobenthos in different type breakwater in Semarang and Demak coastal area.This research held on December 2016 - January 2017 in five different location with different breakwater type. Hard structure in Mangkang (West Semarang), Morosari (Demak district) and Tambak Lorok (North Semarang) and the hybrid engineering in Morosari 2 (Demak district) and Timbulsloko (Demak district). The method used in this study is descriptive comparative. Makrozoobenthos has been found in each station and the highest indeks is in hybrid engineering location. Polychaeta is a genus that dominates at every location because muddy sand is its main habitat.

Mitigation of Hot-Spots in Photovoltaic Systems Using Distributed Power Electronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olalla, Carlos; Hasan, Md. Nazmul; Deline, Chris

In the presence of partial shading and other mismatch factors, bypass diodes may not offer complete elimination of excessive power dissipation due to cell reverse biasing, commonly referred to as hot-spotting in photovoltaic (PV) systems. As a result, PV systems may experience higher failure rates and accelerated ageing. In this paper, a cell-level simulation model is used to assess occurrence of hot-spotting events in a representative residential rooftop system scenario featuring a moderate shading environment. The approach is further used to examine how well distributed power electronics converters mitigate the effects of partial shading and other sources of mismatch bymore » preventing activation of bypass diodes and thereby reducing the chances of heavy power dissipation and hot-spotting in mismatched cells. The simulation results confirm that the occurrence of heavy power dissipation is reduced in all distributed power electronics architectures, and that submodule-level converters offer nearly 100% mitigation of hot-spotting. In addition, the paper further elaborates on the possibility of hot-spot-induced permanent damage, predicting a lifetime energy loss above 15%. In conclusion, this energy loss is fully recoverable with submodule-level power converters that mitigate hot-spotting and prevent the damage.« less

Mitigation of Hot-Spots in Photovoltaic Systems Using Distributed Power Electronics

DOE PAGES

Olalla, Carlos; Hasan, Md. Nazmul; Deline, Chris; ...

2018-03-23

In the presence of partial shading and other mismatch factors, bypass diodes may not offer complete elimination of excessive power dissipation due to cell reverse biasing, commonly referred to as hot-spotting in photovoltaic (PV) systems. As a result, PV systems may experience higher failure rates and accelerated ageing. In this paper, a cell-level simulation model is used to assess occurrence of hot-spotting events in a representative residential rooftop system scenario featuring a moderate shading environment. The approach is further used to examine how well distributed power electronics converters mitigate the effects of partial shading and other sources of mismatch bymore » preventing activation of bypass diodes and thereby reducing the chances of heavy power dissipation and hot-spotting in mismatched cells. The simulation results confirm that the occurrence of heavy power dissipation is reduced in all distributed power electronics architectures, and that submodule-level converters offer nearly 100% mitigation of hot-spotting. In addition, the paper further elaborates on the possibility of hot-spot-induced permanent damage, predicting a lifetime energy loss above 15%. In conclusion, this energy loss is fully recoverable with submodule-level power converters that mitigate hot-spotting and prevent the damage.« less

Mitigation of lung injury after accidental exposure to radiation.

PubMed

Mahmood, J; Jelveh, S; Calveley, V; Zaidi, A; Doctrow, S R; Hill, R P

2011-12-01

There is a serious need to develop effective mitigators against accidental radiation exposures. In radiation accidents, many people may receive nonuniform whole-body or partial-body irradiation. The lung is one of the more radiosensitive organs, demonstrating pneumonitis and fibrosis that are believed to develop at least partially because of radiation-induced chronic inflammation. Here we addressed the crucial questions of how damage to the lung can be mitigated and whether the response is affected by irradiation to the rest of the body. We examined the widely used dietary supplement genistein given at two dietary levels (750 or 3750 mg/kg) to Fischer rats irradiated with 12 Gy to the lung or 8 Gy to the lung + 4 Gy to the whole body excluding the head and tail (whole torso). We found that genistein had promising mitigating effects on oxidative damage, pneumonitis and fibrosis even at late times (36 weeks) when drug treatment was initiated 1 week after irradiation and stopped at 28 weeks postirradiation. The higher dose of genistein showed no greater beneficial effect. Combined lung and whole-torso irradiation caused more lung-related severe morbidity resulting in euthanasia of the animals than lung irradiation alone.

New Tsunami Response, Mitigation, and Recovery Planning "Playbooks" for California (USA) Maritime Communities

NASA Astrophysics Data System (ADS)

Wilson, R. I.; Lynett, P. J.; Miller, K.; Eskijian, M.; Dengler, L. A.; Ayca, A.; Keen, A.; Admire, A. R.; Siegel, J.; Johnson, L. A.; Curtis, E.; Hornick, M.

2015-12-01

The 2010 Chile and 2011 Japan tsunamis both struck the California coast offering valuable experience and raised a number of significant issues for harbor masters, port captains, and other maritime entities. There was a general call for more planning products to help guide maritime communities in their tsunami response, mitigation, and recovery activities. The State of California is working with the U.S. Federal Emergency Management Agency (FEMA), the U.S. National Tsunami Hazard Mitigation Program (NTHMP), and other tsunami experts to provide communities with new tsunami planning tools to address these issues: Response Playbooks and plans have been developed for ports and harbors identifying potential tsunami current hazards and related damage for various size events. Maps have been generated showing minor, moderate, and severe damage levels that have been linked to current velocity thresholds of 3, 6, and 9 knots, respectively. Knowing this information allows harbor personnel to move ships or strengthen infrastructure prior to the arrival of distant source tsunamis. Damage probability tools and mitigation plans have been created to help reduce tsunami damage by evaluating the survivability of small and large vessels in harbors and ports. These results were compared to the actual damage assessments performed in California and Japan following the 2011 Japanese tsunami. Fragility curves were developed based on current velocity and direction to help harbor and port officials upgrade docks, piles, and related structures. Guidance documents are being generated to help in the development of both local and statewide recovery plans. Additional tools, like post-tsunami sediment and debris movement models, will allow harbors and ports to better understand if and where recovery issues are most likely to occur. Streamlining the regulatory and environmental review process is also a goal of the guidance. These maritime products and procedures are being integrated into guidance through the NTHMP to help other U.S. states/territories/commonwealths develop their own tsunami planning tools. This will lead to more accurate, consistent, and cost-effective tsunami planning strategies within the U.S.

A Quantitative Examination Whether Education Mitigates Stress Levels among Law Enforcement Officers

ERIC Educational Resources Information Center

Metts, Gary A.

2012-01-01

Stress is damaging if it is continual, overwhelming. and prolonged. Law enforcement officers face stressful events daily. A relationship exists between stress levels and the physical and psychological effects to the human body. Although there is a general understanding of the damage stress can do physically and psychologically, many elements that…

Stringent Mitigation Policy Implied By Temperature Impacts on Economic Growth

NASA Astrophysics Data System (ADS)

Moore, F.; Turner, D.

2014-12-01

Integrated assessment models (IAMs) compare the costs of greenhouse gas mitigation with damages from climate change in order to evaluate the social welfare implications of climate policy proposals and inform optimal emissions reduction trajectories. However, these models have been criticized for lacking a strong empirical basis for their damage functions, which do little to alter assumptions of sustained GDP growth, even under extreme temperature scenarios. We implement empirical estimates of temperature effects on GDP growth-rates in the Dynamic Integrated Climate and Economy (DICE) model via two pathways, total factor productivity (TFP) growth and capital depreciation. Even under optimistic adaptation assumptions, this damage specification implies that optimal climate policy involves the elimination of emissions in the near future, the stabilization of global temperature change below 2°C, and a social cost of carbon (SCC) an order of magnitude larger than previous estimates. A sensitivity analysis shows that the magnitude of growth effects, the rate of adaptation, and the dynamic interaction between damages from warming and GDP are three critical uncertainties and an important focus for future research.

Intelligent Multi-scale Sensors for Damage Identification and Mitigation in Woven Composites for Aerospace Structural Applications

DTIC Science & Technology

2012-08-15

Bragg grating ( FBG ) sensors within these composite structures allows one to correlate sensor response features to “critical damage events” within the...material. The unique capabilities of this identification strategy are due to the detailed information obtained from the FBG sensors and the... FBG sensors relate to damage states not merely strain amplitudes. The research objectives of this project were therefore to:  demonstrate FBG

Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice

PubMed Central

Venkateswaran, Kavya; Shrivastava, Anju; Agrawala, Paban K.; Prasad, Ashok; Kalra, Namita; Pandey, Parvat R.; Manda, Kailash; Raj, Hanumantharao G.; Parmar, Virinder S.; Dwarakanath, Bilikere S.

2016-01-01

Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents (MCM) to combat radiation-induced lethality. In the present study, we investigated the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to ameliorate radiation-induced hematopoietic damage and the associated mortality following total body irradiation (TBI) in C57BL/6 mice. Administration of DAMTC 24 hours post TBI alleviated TBI-induced myelo-suppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of mice, while bone marrow (BM) cellularity was restored through enhanced proliferation of the stem cells. It stimulated multi-lineage expansion and differentiation of myeloid progenitors in the BM and induced proliferation of splenic progenitors thereby, facilitating hematopoietic re-population. DAMTC reduced the radiation-induced apoptotic and mitotic death in the hematopoietic compartment. Recruitment of pro-inflammatory M1 macrophages in spleen contributed to the immune-protection linked to the mitigation of hematopoietic injury. Recovery of the hematopoietic compartment correlated well with mitigation of mortality at a lethal dose of 9 Gy, leading to 80% animal survival. Present study establishes the potential of DAMTC to mitigate radiation-induced injury to the hematopoietic system by stimulating the re-population of stem cells from multiple lineages. PMID:27849061

Mitigation of tip vortex cavitation by means of air injection on a Kaplan turbine scale model

NASA Astrophysics Data System (ADS)

Rivetti, A.; Angulo, M.; Lucino, C.; Liscia, S.

2014-03-01

Kaplan turbines operating at full-load conditions may undergo excessive vibration, noise and cavitation. In such cases, damage by erosion associated to tip vortex cavitation can be observed at the discharge ring. This phenomenon involves design features such as (1) overhang of guide vanes; (2) blade profile; (3) gap increasing size with blade opening; (4) suction head; (5) operation point; and (6) discharge ring stiffness, among others. Tip vortex cavitation may cause erosion at the discharge ring and draft tube inlet following a wavy pattern, in which the number of vanes can be clearly identified. Injection of pressurized air above the runner blade centerline was tested as a mean to mitigate discharge ring cavitation damage on a scale model. Air entrance was observed by means of a high-speed camera in order to track the air trajectory toward its mergence with the tip vortex cavitation core. Post-processing of acceleration signals shows that the level of vibration and the RSI frequency amplitude decrease proportionally with air flow rate injected. These findings reveal the potential mitigating effect of air injection in preventing cavitation damage and will be useful in further tests to be performed on prototype, aiming at determining the optimum air flow rate, size and distribution of the injectors.

Benefits of Greenhouse Gas Mitigation on the Supply, Management, and Use of Water Resources in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strzepek, K.; Neumann, Jim; Smith, Joel

Climate change impacts on water resources in the U.S. are likely to be far-reaching and substantial, because the water sector spans many parts of the economy, from supply and demand for agriculture, industry, energy production, transportation and municipal use to damages from natural hazards. This paper provides impact and damage estimates from five water resource-related models in the CIRA frame work, addressing drought risk, flooding damages, water supply and demand, and global water scarcity. The four models differ in the water system assessed, their spatial scale, and the units of assessment, but together they provide a quantitative and descriptive richnessmore » in characterizing water resource sector effects of climate change that no single model can capture. The results also address the sensitivity of these estimates to greenhouse gas emission scenarios, climate sensitivity alternatives, and global climate model selection. While calculating the net impact of climate change on the water sector as a whole may be impractical, because each of the models applied here uses a consistent set of climate scenarios, broad conclusions can be drawn regarding the patterns of change and the benefits of GHG mitigation policies for the water sector. Two key findings emerge: 1) climate mitigation policy substantially reduces the impact of climate change on the water sector across multiple dimensions; and 2) the more managed the water resources system, the more tempered the climate change impacts and the resulting reduction of impacts from climate mitigation policies.« less

A Multi-Model Framework to Achieve Consistent Evaluation of Climate Change Impacts in the United States

NASA Astrophysics Data System (ADS)

Sarofim, M. C.; Martinich, J.; Waldhoff, S.; DeAngelo, B. J.; McFarland, J.; Jantarasami, L.; Shouse, K.; Crimmins, A.; Li, J.

2014-12-01

The Climate Change Impacts and Risk Analysis (CIRA) project establishes a new multi-model framework to systematically assess the physical impacts, economic damages, and risks from climate change. The primary goal of this framework is to estimate the degree to which climate change impacts and damages in the United States are avoided or reduced in the 21st century under multiple greenhouse gas (GHG) emissions mitigation scenarios. The first phase of the CIRA project is a modeling exercise that included two integrated assessment models and 15 sectoral models encompassing five broad impacts sectors: water resources, electric power, infrastructure, human health, and ecosystems. Three consistent socioeconomic and climate scenarios are used to analyze the benefits of global GHG mitigation targets: a reference scenario and two policy scenarios with total radiative forcing targets in 2100 of 4.5 W/m2 and 3.7 W/m2. In this exercise, the implications of key uncertainties are explored, including climate sensitivity, climate model, natural variability, and model structures and parameters. This presentation describes the motivations and goals of the CIRA project; the design and academic contribution of the first CIRA modeling exercise; and briefly summarizes several papers published in a special issue of Climatic Change. The results across impact sectors show that GHG mitigation provides benefits to the United States that increase over time, the effects of climate change can be strongly influenced by near-term policy choices, adaptation can reduce net damages, and impacts exhibit spatial and temporal patterns that may inform mitigation and adaptation policy discussions.

Benefits of Greenhouse Gas Mitigation on the Supply, Management, and Use of Water Resources in the United States

DOE PAGES

Strzepek, K.; Neumann, Jim; Smith, Joel; ...

2014-11-29

Climate change impacts on water resources in the U.S. are likely to be far-reaching and substantial, because the water sector spans many parts of the economy, from supply and demand for agriculture, industry, energy production, transportation and municipal use to damages from natural hazards. This paper provides impact and damage estimates from five water resource-related models in the CIRA frame work, addressing drought risk, flooding damages, water supply and demand, and global water scarcity. The four models differ in the water system assessed, their spatial scale, and the units of assessment, but together they provide a quantitative and descriptive richnessmore » in characterizing water resource sector effects of climate change that no single model can capture. The results also address the sensitivity of these estimates to greenhouse gas emission scenarios, climate sensitivity alternatives, and global climate model selection. While calculating the net impact of climate change on the water sector as a whole may be impractical, because each of the models applied here uses a consistent set of climate scenarios, broad conclusions can be drawn regarding the patterns of change and the benefits of GHG mitigation policies for the water sector. Two key findings emerge: 1) climate mitigation policy substantially reduces the impact of climate change on the water sector across multiple dimensions; and 2) the more managed the water resources system, the more tempered the climate change impacts and the resulting reduction of impacts from climate mitigation policies.« less

Dealing with Natural Disasters: Preparedness versus Post-Event Response

NASA Astrophysics Data System (ADS)

Sitar, N.

2015-12-01

Management or mitigation of natural disasters is comprised of two distinct elements: disaster preparedness and disaster response. Fundamentally disasters fall into two categories: 1) those whose timing can be predicted and evaluated in advance, such as hurricanes, floods, tsunamis, or even sea level rise; and 2) those that can be anticipated based on analysis, but their exact timing is unknown, such as earthquakes and landslides. Consequently, the type of response and options available for scientific and engineering consultation are fundamentally different. The common aspects of all natural disasters is that there is evidence of past events either historical or geologic, or both. Thus, given past evidence, scientists and engineers have an opportunity to recommend and guide development and implementation of long term or permanent mitigation measures, such as improving the resiliency of the infrastructure and emergency preparedness. However, the appropriate mitigation measures are very much a function of the type of event. Severe atmospheric events, such as hurricanes, typically can be predicted several days in advance and scientists and engineers have a role in guiding preparation of specific additional, temporary, mitigation measures and selective evacuation, as appropriate. In contrast, while earthquake potential of a given region may be well recognized, the actual timing of the event is an unknown and, consequently, the primary defense is in developing sufficiently resilient infrastructure which can be enhanced with early warning systems. Similarly, the type of damage caused by flooding, e.g. hurricane and tsunami, is significantly different from the type of damage caused by an earthquake in that flooding damage is pervasive affecting large contiguous areas wiping out all infrastructure whereas earthquake or landslide damage tends to be clustered with many elements of infrastructure remaining fully or somewhat operable. This distinction is very important when it comes to the type of technical guidance that is needed following such events. This presentation highlights lessons learned from post-event reconnaissance as a part of the NSF-funded Geotechnical Extreme Event Reconnaissance (GEER) over the last two decades.

Acehnese reefs in the wake of the Asian tsunami.

PubMed

Baird, Andrew H; Campbell, Stuart J; Anggoro, Aji W; Ardiwijaya, Rizya L; Fadli, Nur; Herdiana, Yudi; Kartawijaya, Tasrif; Mahyiddin, Dodent; Mukminin, Ahmad; Pardede, Shinta T; Pratchett, Morgan S; Rudi, Edi; Siregar, Achis M

2005-11-08

The Sumatra-Andanaman tsunami was one of the greatest natural disasters in recorded human history. Here, we show that on the northwest coast of Aceh, Indonesia, where the tsunami was most ferocious, the damage to corals, although occasionally spectacular, was surprisingly limited. We detected no change in shallow coral assemblages between March 2003 and March 2005, with the exception of one site smothered by sediment. Direct tsunami damage was dependent on habitat and largely restricted to corals growing in unconsolidated substrata, a feature unique to tsunami disturbance. Reef condition, however, varied widely within the region and was clearly correlated with human impacts prior to the tsunami. Where fishing has been controlled, coral cover was high. In contrast, reefs exposed to destructive fishing had low coral cover and high algal cover, a phase shift the tsunami may exacerbate with an influx of sediments and nutrients. Healthy reefs did not mitigate the damage on land. Inundation distance was largely determined by wave height and coastal topography. We conclude that although chronic human misuse has been much more destructive to reefs in Aceh than this rare natural disturbance, human modification of the reef did not contribute to the magnitude of damage on land.

Probing multi-scale mechanical damage in connective tissues using X-ray diffraction.

PubMed

Bianchi, Fabio; Hofmann, Felix; Smith, Andrew J; Thompson, Mark S

2016-11-01

The accumulation of microstructural collagen damage following repetitive loading is linked to painful and debilitating tendon injuries. As a hierarchical, semi-crystalline material, collagen mechanics can be studied using X-ray diffraction. The aim of the study was to describe multi-structural changes in tendon collagen following controlled plastic damage (5% permanent strain). We used small angle X-ray scattering (SAXS) to interrogate the spacing of collagen molecules within a fibril, and wide angle X-ray scattering (WAXS) to measure molecular strains under macroscopic loading. Simultaneous recordings of SAXS and WAXS patterns, together with whole-tissue strain in physiologically hydrated rat-tail tendons were made during increments of in situ tensile loading. Results showed that while tissue level modulus was unchanged, fibril modulus decreased significantly, and molecular modulus significantly increased. Further, analysis of higher order SAXS peaks suggested structural changes in the gap and overlap regions, possibly localising the damage to molecular cross-links. Our results provide new insight into the fundamental damage processes at work in collagenous tissues and point to new directions for their mitigation and repair. This article reports the first in situ loading synchrotron studies on mechanical damage in collagenous tissues. We provide new insight into the nano- and micro-structural mechanisms of damage processes. Pre-damaged tendons showed differential alteration of moduli at macro, micro and nano-scales as measured using X-ray scattering techniques. Detailed analysis of higher order diffraction peaks suggested damage is localised to molecular cross-links. The results are consistent with previous X-ray scattering studies of tendons and also with recent thermal stability studies on damaged material. Detailed understanding of damage mechanisms is essential in the development of new therapies promoting tissue repair. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model.

PubMed

Jackson, Isabel L; Zodda, Andrew; Gurung, Ganga; Pavlovic, Radmila; Kaytor, Michael D; Kuskowski, Michael A; Vujaskovic, Zeljko

2017-12-01

BIO 300 nanosuspension (Humanetics Corporation) is being developed as a medical countermeasure (MCM) for the mitigation of the delayed effects of acute radiation exposure, specifically pneumonitis and fibrosis of the lung. The objective of this study was to determine the best dose and treatment duration of BIO 300 to mitigate lung injury and improve the likelihood for survival in C57L/J mice exposed to whole thorax lung irradiation (WTLI). Age- and sex-matched C57L/J mice received a single dose of 11.0 or 12.5 Gy WTLI. BIO 300 (200 or 400 mg·kg -1 , oral gavage) was administered daily starting 24 h post-exposure for a duration of 2, 4, 6 or, in some cases, 10 weeks. Non-treated controls were included for comparison in both sexes. Animals were observed daily for signs of major morbidity. Respiratory function was assessed biweekly. Lungs were collected, weighed and paraffin embedded for histological evaluation post mortem. BIO 300 administered at an oral dose of 400 mg·kg -1 for 4 to 6 weeks starting 24 h post-WTLI reduced morbidity associated with WTLI. The improvement in survival correlated with reduced respiratory frequency and enhanced pause. The irradiated lungs of mice treated with BIO 300 (400 mg·kg -1 ) for 4 to 6 weeks displayed less morphological damage and airway loss due to oedema, congestion and fibrotic scarring than the untreated, irradiated controls. BIO 300 is a promising MCM candidate to mitigate pneumonitis/fibrosis when administered daily for 4-6 weeks starting 24 h post-exposure. © 2017 The British Pharmacological Society.

Estimating the probability of mountain pine beetle red-attack damage

Treesearch

Michael A Wulder; J. C. White; Barbara J Bentz; M. F. Alvarez; N. C. Coops

2006-01-01

Accurate spatial information on the location and extent of mountain pine beetle infestation is critical for the planning of mitigation and treatment activities. Areas of mixed forest and variable terrain present unique challenges for the detection and mapping of mountain pine beetle red-attack damage, as red-attack has a more heterogeneous distribution under these...

Solutions Network Formulation Report. NASA's Potential Contributions using ASTER Data in Marine Hazard Mitigation

NASA Technical Reports Server (NTRS)

Fletcher, Rose

2010-01-01

The 28-foot storm surge from Hurricane Katrina pushed inland along bays and rivers for a distance of 12 miles in some areas, contributing to the damage or destruction of about half of the fleet of boats in coastal Mississippi. Most of those boats had sought refuge in back bays and along rivers. Some boats were spared damage because the owners chose their mooring site well. Gulf mariners need a spatial analysis tool that provides guidance on the safest places to anchor their boats during future hurricanes. This product would support NOAA s mission to minimize the effects of coastal hazards through awareness, education, and mitigation strategies and could be incorporated in the Coastal Risk Atlas decision support tool.

Fungal Diversity in Field Mold-Damaged Soybean Fruits and Pathogenicity Identification Based on High-Throughput rDNA Sequencing

PubMed Central

Liu, Jiang; Deng, Jun-cai; Yang, Cai-qiong; Huang, Ni; Chang, Xiao-li; Zhang, Jing; Yang, Feng; Liu, Wei-guo; Wang, Xiao-chun; Yong, Tai-wen; Du, Jun-bo; Shu, Kai; Yang, Wen-yu

2017-01-01

Continuous rain and an abnormally wet climate during harvest can easily lead to soybean plants being damaged by field mold (FM), which can reduce seed yield and quality. However, to date, the underlying pathogen and its resistance mechanism have remained unclear. The objective of the present study was to investigate the fungal diversity of various soybean varieties and to identify and confirm the FM pathogenic fungi. A total of 62,382 fungal ITS1 sequences clustered into 164 operational taxonomic units (OTUs) with 97% sequence similarity; 69 taxa were recovered from the samples by internal transcribed spacer (ITS) region sequencing. The fungal community compositions differed among the tested soybeans, with 42 OTUs being amplified from all varieties. The quadratic relationships between fungal diversity and organ-specific mildew indexes were analyzed, confirming that mildew on soybean pods can mitigate FM damage to the seeds. In addition, four potentially pathogenic fungi were isolated from FM-damaged soybean fruits; morphological and molecular identification confirmed these fungi as Aspergillus flavus, A. niger, Fusarium moniliforme, and Penicillium chrysogenum. Further re-inoculation experiments demonstrated that F. moniliforme is dominant among these FM pathogenic fungi. These results lay the foundation for future studies on mitigating or preventing FM damage to soybean. PMID:28515718

Flood loss assessment in Can Tho City, Vietnam

NASA Astrophysics Data System (ADS)

Do, T. C.; Kreibich, H.

2012-04-01

Floods are recurring events in the Lower Mekong Basin resulting in loss of life and property, causing damage to agriculture and rural infrastructure, and disrupting social and economic activities. Flood management and mitigation has become a priority issue at the national and regional levels. Besides, it is expected that large areas of the Mekong delta, the Red River delta and the central coast will be flooded by sea-level rise due to climate change. Can Tho City is ranked under the five most flood-tide-influenced cities of Vietnam. It is the biggest city in the Mekong delta and it is located near the Hau river. Like other region of the Mekong delta, Can Tho suffers due to floods from upstream and flood tides from the sea. In the flood season large rural areas of the city are flooded, particularly during tidal days. Flood risk management policy includes preparative measures for living with floods and to minimise the damage caused by floods as well as to take advantage of floods for sustainable development. An intensive literature review, including administrative reports as well as expert interviews have been undertaken to gain more insight into flood characteristics, their consequences and risk mitigation. Therefore, flood damaging processes and trends have been reviewed for Can Tho City and the Mekong Basin in Vietnam. Additionally, suitable flood damage estimation methodologies have been collected as important input for flood risk analyses. On this basis it has been investigated which flood risk mitigation and management strategies promise to be effective in Can Tho City, Vietnam.

Retinal light toxicity

PubMed Central

Youssef, P N; Sheibani, N; Albert, D M

2011-01-01

The ability of light to enact damage on the neurosensory retina and underlying structures has been well understood for hundreds of years. While the eye has adapted several mechanisms to protect itself from such damage, certain exposures to light can still result in temporal or permanent damage. Both clinical observations and laboratory studies have enabled us to understand the various ways by which the eye can protect itself from such damage. Light or electromagnetic radiation can result in damage through photothermal, photomechanical, and photochemical mechanisms. The following review seeks to describe these various processes of injury and many of the variables, which can mitigate these modes of injury. PMID:21178995

Bioinspired self-healing materials: lessons from nature

PubMed Central

Cremaldi, Joseph C

2018-01-01

Healing is an intrinsic ability in the incredibly biodiverse populations of the plant and animal kingdoms created through evolution. Plants and animals approach healing in similar ways but with unique pathways, such as damage containment in plants or clotting in animals. After analyzing the examples of healing and defense mechanisms found in living nature, eight prevalent mechanisms were identified: reversible muscle control, clotting, cellular response, layering, protective surfaces, vascular networks or capsules, exposure, and replenishable functional coatings. Then the relationship between these mechanisms, nature’s best (evolutionary) methods of mitigating and healing damage, and existing technology in self-healing materials are described. The goals of this top-level overview are to provide a framework for relating the behavior seen in living nature to bioinspired materials, act as a resource to addressing the limitations/problems with existing materials, and open up new avenues of insight and research into self-healing materials. PMID:29600152

In situ mitigation of subsurface and peripheral focused ion beam damage via simultaneous pulsed laser heating

DOE PAGES

Stanford, Michael G.; Lewis, Brett B.; Iberi, Vighter O.; ...

2016-02-16

Focused helium and neon ion (He(+)/Ne(+) ) beam processing has recently been used to push resolution limits of direct-write nanoscale synthesis. The ubiquitous insertion of focused He(+) /Ne(+) beams as the next-generation nanofabrication tool-of-choice is currently limited by deleterious subsurface and peripheral damage induced by the energetic ions in the underlying substrate. The in situ mitigation of subsurface damage induced by He(+)/Ne(+) ion exposures in silicon via a synchronized infrared pulsed laser-assisted process is demonstrated. The pulsed laser assist provides highly localized in situ photothermal energy which reduces the implantation and defect concentration by greater than 90%. The laser-assisted exposuremore » process is also shown to reduce peripheral defects in He(+) patterned graphene, which makes this process an attractive candidate for direct-write patterning of 2D materials. In conclusion, these results offer a necessary solution for the applicability of high-resolution direct-write nanoscale material processing via focused ion beams.« less

The physical vulnerability of elements at risk: a methodology based on fluid and classical mechanics

NASA Astrophysics Data System (ADS)

Mazzorana, B.; Fuchs, S.; Levaggi, L.

2012-04-01

The impacts of the flood events occurred in autumn 2011 in the Italian regions Liguria and Tuscany revived the engagement of the public decision makers to enhance in synergy flood control and land use planning. In this context, the design of efficient flood risk mitigation strategies and their subsequent implementation critically relies on a careful vulnerability analysis of both, the immobile and mobile elements at risk potentially exposed to flood hazards. Based on fluid and classical mechanics notions we developed computation schemes enabling for a dynamic vulnerability and risk analysis facing a broad typological variety of elements at risk. The methodological skeleton consists of (1) hydrodynamic computation of the time-varying flood intensities resulting for each element at risk in a succession of loading configurations; (2) modelling the mechanical response of the impacted elements through static, elasto-static and dynamic analyses; (3) characterising the mechanical response through proper structural damage variables and (4) economic valuation of the expected losses as a function of the quantified damage variables. From a computational perspective we coupled the description of the hydrodynamic flow behaviour and the induced structural modifications of the elements at risk exposed. Valuation methods, suitable to support a correct mapping from the value domains of the physical damage variables to the economic loss values are discussed. In such a way we target to complement from a methodological perspective the existing, mainly empirical, vulnerability and risk assessment approaches to refine the conceptual framework of the cost-benefit analysis. Moreover, we aim to support the design of effective flood risk mitigation strategies by diminishing the main criticalities within the systems prone to flood risk.

Heterogeneity, pore pressure, and injectate chemistry: Control measures for geologic carbon storage

DOE PAGES

Dewers, Thomas; Eichhubl, Peter; Ganis, Ben; ...

2017-11-28

Desirable outcomes for geologic carbon storage include maximizing storage efficiency, preserving injectivity, and avoiding unwanted consequences such as caprock or wellbore leakage or induced seismicity during and post injection. Here, to achieve these outcomes, three control measures are evident including pore pressure, injectate chemistry, and knowledge and prudent use of geologic heterogeneity. Field, experimental, and modeling examples are presented that demonstrate controllable GCS via these three measures. Observed changes in reservoir response accompanying CO 2 injection at the Cranfield (Mississippi, USA) site, along with lab testing, show potential for use of injectate chemistry as a means to alter fracture permeabilitymore » (with concomitant improvements for sweep and storage efficiency). Further control of reservoir sweep attends brine extraction from reservoirs, with benefit for pressure control, mitigation of reservoir and wellbore damage, and water use. State-of-the-art validated models predict the extent of damage and deformation associated with pore pressure hazards in reservoirs, timing and location of networks of fractures, and development of localized leakage pathways. Experimentally validated geomechanics models show where wellbore failure is likely to occur during injection, and efficiency of repair methods. Use of heterogeneity as a control measure includes where best to inject, and where to avoid attempts at storage. Lastly, an example is use of waste zones or leaky seals to both reduce pore pressure hazards and enhance residual CO 2 trapping.« less

Heterogeneity, pore pressure, and injectate chemistry: Control measures for geologic carbon storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dewers, Thomas; Eichhubl, Peter; Ganis, Ben

Desirable outcomes for geologic carbon storage include maximizing storage efficiency, preserving injectivity, and avoiding unwanted consequences such as caprock or wellbore leakage or induced seismicity during and post injection. Here, to achieve these outcomes, three control measures are evident including pore pressure, injectate chemistry, and knowledge and prudent use of geologic heterogeneity. Field, experimental, and modeling examples are presented that demonstrate controllable GCS via these three measures. Observed changes in reservoir response accompanying CO 2 injection at the Cranfield (Mississippi, USA) site, along with lab testing, show potential for use of injectate chemistry as a means to alter fracture permeabilitymore » (with concomitant improvements for sweep and storage efficiency). Further control of reservoir sweep attends brine extraction from reservoirs, with benefit for pressure control, mitigation of reservoir and wellbore damage, and water use. State-of-the-art validated models predict the extent of damage and deformation associated with pore pressure hazards in reservoirs, timing and location of networks of fractures, and development of localized leakage pathways. Experimentally validated geomechanics models show where wellbore failure is likely to occur during injection, and efficiency of repair methods. Use of heterogeneity as a control measure includes where best to inject, and where to avoid attempts at storage. Lastly, an example is use of waste zones or leaky seals to both reduce pore pressure hazards and enhance residual CO 2 trapping.« less

4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells

PubMed Central

Suzuki, Maiko; Everett, Eric T.; Whitford, Gary M.; Bartlett, John D.

2017-01-01

Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts. Cell stress induces gene repression, mitochondrial damage and apoptosis. An aromatic fatty acid, 4-phenylbutyrate (4PBA) is a chemical chaperone that interacts with misfolded proteins to prevent ER stress. We hypothesized that 4PBA ameliorates fluoride-induced ER stress in ameloblasts. To determine whether 4PBA protects ameloblasts from fluoride toxicity, we analyzed gene expression of Tgf-β1, Bcl2/Bax ratio and cytochrome-c release in vitro. In vivo, we measured fluorosis levels, enamel hardness and fluoride concentration. Fluoride treated Ameloblast-lineage cells (ALC) had decreased Tgf-β1 expression and this was reversed by 4PBA treatment. The anti-apoptotic Blc2/Bax ratio was significantly increased in ALC cells treated with fluoride/4PBA compared to fluoride treatment alone. Fluoride treatment induced cytochrome-c release from mitochondria into the cytosol and this was inhibited by 4PBA treatment. These results suggest that 4PBA mitigates fluoride-induced gene suppression, apoptosis and mitochondrial damage in vitro. In vivo, C57BL/6J mice were provided fluoridated water for six weeks with either fluoride free control-chow or 4PBA-containing chow (7 g/kg 4PBA). With few exceptions, enamel microhardness, fluorosis levels, and fluoride concentrations of bone and urine did not differ significantly between fluoride treated animals fed with control-chow or 4PBA-chow. Although 4PBA mitigated high-dose fluoride toxicity in vitro, a diet rich in 4PBA did not attenuate dental fluorosis in rodents. Perhaps, not enough intact 4PBA reaches the rodent ameloblasts necessary to reverse the effects of fluoride toxicity. Further studies will be required to optimize protocols for 4PBA administration in vivo in order to evaluate the effect of 4PBA on dental fluorosis. PMID:28553235

4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells.

PubMed

Suzuki, Maiko; Everett, Eric T; Whitford, Gary M; Bartlett, John D

2017-01-01

Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts. Cell stress induces gene repression, mitochondrial damage and apoptosis. An aromatic fatty acid, 4-phenylbutyrate (4PBA) is a chemical chaperone that interacts with misfolded proteins to prevent ER stress. We hypothesized that 4PBA ameliorates fluoride-induced ER stress in ameloblasts. To determine whether 4PBA protects ameloblasts from fluoride toxicity, we analyzed gene expression of Tgf -β 1, Bcl2 / Bax ratio and cytochrome-c release in vitro . In vivo , we measured fluorosis levels, enamel hardness and fluoride concentration. Fluoride treated Ameloblast-lineage cells (ALC) had decreased Tgf -β 1 expression and this was reversed by 4PBA treatment. The anti-apoptotic Blc2 / Bax ratio was significantly increased in ALC cells treated with fluoride/4PBA compared to fluoride treatment alone. Fluoride treatment induced cytochrome-c release from mitochondria into the cytosol and this was inhibited by 4PBA treatment. These results suggest that 4PBA mitigates fluoride-induced gene suppression, apoptosis and mitochondrial damage in vitro . In vivo , C57BL/6J mice were provided fluoridated water for six weeks with either fluoride free control-chow or 4PBA-containing chow (7 g/kg 4PBA). With few exceptions, enamel microhardness, fluorosis levels, and fluoride concentrations of bone and urine did not differ significantly between fluoride treated animals fed with control-chow or 4PBA-chow. Although 4PBA mitigated high-dose fluoride toxicity in vitro , a diet rich in 4PBA did not attenuate dental fluorosis in rodents. Perhaps, not enough intact 4PBA reaches the rodent ameloblasts necessary to reverse the effects of fluoride toxicity. Further studies will be required to optimize protocols for 4PBA administration in vivo in order to evaluate the effect of 4PBA on dental fluorosis.

DEVELOPMENT OF PERMANENT MECHANICAL REPAIR SLEEVE FOR PLASTIC PIPE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hitesh Patadia

2005-04-29

The report presents a comprehensive summary of the prototype development process utilized towards the development of a permanent mechanical repair fitting intended to be installed on damaged PE mains under blowing gas conditions. Specifically, the step by step construction approach is presented and the experimental data to support the mitigation of ensuing slow crack growth (SCG) of the damage area.

Overcoming Barriers to Firewise Actions by Residents. Final Report to Joint Fire Science Program

Treesearch

James D. Absher; Jerry J. Vaske; Katie M. Lyon

2013-01-01

Encouraging the public to take action (e.g., creating defensible space) that can reduce the likelihood of wildfire damage and decrease the likelihood of injury is a common approach to increasing wildfire safety and damage mitigation. This study was designed to improve our understanding of both individual and community actions that homeowners currently do or might take...

Cell damage caused by ultraviolet B radiation in the desert cyanobacterium Phormidium tenue and its recovery process.

PubMed

Wang, Gaohong; Deng, Songqiang; Liu, Jiafeng; Ye, Chaoran; Zhou, Xiangjun; Chen, Lanzhou

2017-10-01

Phormidium tenue, a cyanobacterium that grows in the topsoil of biological soil crusts (BSCs), has the highest recovery rate among desert crust cyanobacteria after exposure to ultraviolet B (UV-B) radiation. However, the mechanism underlying its recovery process is unclear. To address this issue, we measured chlorophyll a fluorescence, generation of reactive oxygen species (ROS), lipid peroxidation, and repair of DNA breakage in P. tenue following exposure to UV-B. We found that UV-B radiation at all doses tested reduced photosynthesis and induced cell damage in P. tenue. However, P. tenue responded to UV-B radiation by rapidly reducing photosynthetic activity, which protects the cell by leaking less ROS. Antioxidant enzymes, DNA damage repair systems, and UV absorbing pigments were then induced to mitigate the damage caused by UV-B radiation. The addition of exogenous antioxidant chemicals ascorbate and N-acetylcysteine also mitigated the harmful effects caused by UV-B radiation and enhanced the recovery process. These chemicals could aid in the resistance of P. tenue to the exposure of intense UV-B radiation in desertified areas when inoculated onto the sand surface to form artificial algal crusts. Copyright © 2017. Published by Elsevier Inc.

Cascading costs: an economic nitrogen cycle.

PubMed

Moomaw, William R; Birch, Melissa B L

2005-09-01

The chemical nitrogen cycle is becoming better characterized in terms of fluxes and reservoirs on a variety of scales. Galloway has demonstrated that reactive nitrogen can cascade through multiple ecosystems causing environmental damage at each stage before being denitrified to N(2). We propose to construct a parallel economic nitrogen cascade (ENC) in which economic impacts of nitrogen fluxes can be estimated by the costs associated with each stage of the chemical cascade. Using economic data for the benefits of damage avoided and costs of mitigation in the Chesapeake Bay basin, we have constructed an economic nitrogen cascade for the region. Since a single ton of nitrogen can cascade through the system, the costs also cascade. Therefore evaluating the benefits of mitigating a ton of reactive nitrogen released needs to consider the damage avoided in all of the ecosystems through which that ton would cascade. The analysis reveals that it is most cost effective to remove a ton of nitrogen coming from combustion since it has the greatest impact on human health and creates cascading damage through the atmospheric, terrestrial, aquatic and coastal ecosystems. We will discuss the implications of this analysis for determining the most cost effective policy option for achieving environmental quality goals.

Cascading costs: an economic nitrogen cycle.

PubMed

Moomaw, William R; Birch, Melissa B L

2005-12-01

The chemical nitrogen cycle is becoming better characterized in terms of fluxes and reservoirs on a variety of scales. Galloway has demonstrated that reactive nitrogen can cascade through multiple ecosystems causing environmental damage at each stage before being denitrified to N2. We propose to construct a parallel economic nitrogen cascade (ENC) in which economic impacts of nitrogen fluxes can be estimated by the costs associated with each stage of the chemical cascade. Using economic data for the benefits of damage avoided and costs of mitigation in the Chesapeake Bay basin, we have constructed an economic nitrogen cascade for the region. Since a single tonne of nitrogen can cascade through the system, the costs also cascade. Therefore evaluating the benefits of mitigating a tonne of reactive nitrogen released needs to consider the damage avoided in all of the ecosystems through which that tonne would cascade. The analysis reveals that it is most cost effective to remove a tonne of nitrogen coming from combustion since it has the greatest impact on human health and creates cascading damage through the atmospheric, terrestrial, aquatic and coastal ecosystems. We will discuss the implications of this analysis for determining the most cost effective policy option for achieving environmental quality goals.

NASA's Research in Aircraft Vulnerability Mitigation

NASA Technical Reports Server (NTRS)

Allen, Cheryl L.

2005-01-01

Since its inception in 1958, the National Aeronautics and Space Administration s (NASA) role in civil aeronautics has been to develop high-risk, high-payoff technologies to meet critical national aviation challenges. Following the events of Sept. 11, 2001, NASA recognized that it now shared the responsibility for improving homeland security. The NASA Strategic Plan was modified to include requirements to enable a more secure air transportation system by investing in technologies and collaborating with other agencies, industry, and academia. NASA is conducting research to develop and advance innovative and commercially viable technologies that will reduce the vulnerability of aircraft to threats or hostile actions, and identify and inform users of potential vulnerabilities in a timely manner. Presented in this paper are research plans and preliminary status for mitigating the effects of damage due to direct attacks on civil transport aircraft. The NASA approach to mitigation includes: preventing loss of an aircraft due to a hit from man-portable air defense systems; developing fuel system technologies that prevent or minimize in-flight vulnerability to small arms or other projectiles; providing protection from electromagnetic energy attacks by detecting directed energy threats to aircraft and on/off-board systems; and minimizing the damage due to high-energy attacks (explosions and fire) by developing advanced lightweight, damage-resistant composites and structural concepts. An approach to preventing aircraft from being used as weapons of mass destruction will also be discussed.

Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing

NASA Astrophysics Data System (ADS)

Briard, Jennie G.; Poisson, Jessica S.; Turner, Tracey R.; Capicciotti, Chantelle J.; Acker, Jason P.; Ben, Robert N.

2016-03-01

During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol function by a number of different mechanisms but do not mitigate or control ice recrystallization at concentrations utilized in cryopreservation procedures. In North America, cryopreservation of human red blood cells (RBCs) utilizes high concentrations of glycerol. RBC units frozen under these conditions must be subjected to a time-consuming deglycerolization process after thawing in order to remove the glycerol to <1% prior to transfusion thus limiting the use of frozen RBC units in emergency situations. We have identified several low molecular mass ice recrystallization inhibitors (IRIs) that are effective cryoprotectants for human RBCs, resulting in 70-80% intact RBCs using only 15% glycerol and slow freezing rates. These compounds are capable of reducing the average ice crystal size of extracellular ice relative to a 15% glycerol control validating the positive correlation between a reduction in ice crystal size and increased post-thaw recovery of RBCs. The most potent IRI from this study is also capable of protecting frozen RBCs against the large temperature fluctuations associated with transient warming.

Control of runaway electron energy using externally injected whistler waves

NASA Astrophysics Data System (ADS)

Guo, Zehua; McDevitt, Christopher J.; Tang, Xian-Zhu

2018-03-01

One way of mitigating runaway damage of the plasma-facing components in a tokamak fusion reactor is by limiting the runaway electron energy under a few MeV, while not necessarily reducing the runaway current appreciably. Here, we describe a physics mechanism by which such momentum space engineering of the runaway distribution can be facilitated by externally injected high-frequency electromagnetic waves such as whistler waves. The drastic impact that wave-induced scattering can have on the runaway energy distribution is fundamentally the result of its ability to control the runaway vortex in the momentum space. The runaway vortex, which is a local circulation of runaways in momentum space, is the outcome of the competition between Coulomb collisions, synchrotron radiation damping, and runaway acceleration by the parallel electric field. By introducing a wave that resonantly interacts with runaways in a particular range of energies which is mildly relativistic, the enhanced scattering would reshape the vortex by cutting off the part that is highly relativistic. The efficiency of resonant scattering accentuates the requirement that the wave amplitude can be small so the power requirement from external wave injection is practical for the mitigation scheme.

Controlling runaway vortex via externally injected high-frequency electromagnetic waves

NASA Astrophysics Data System (ADS)

Guo, Zehua; McDevitt, Chris; Tang, Xianzhu

2017-10-01

One way of mitigating runaway damage of the plasma-facing components in a tokamak fusion reactor is by limiting the runaway electron energy under a few MeV, while not necessarily reducing the runaway current appreciably. Here we describe a physics mechanism by which such momentum space engineering of the runaway distribution can be facilitated by externally injected high-frequency electromagnetic waves such as the whistler waves. The drastic impact that wave-induced scattering can have on the runaway energy distribution is fundamentally the result of its ability to control the runaway vortex in the momentum space. The runaway vortex, which is a local circulation of runaways in momentum space, is the outcome of the competition between Coulomb collisions, synchrotron radiation damping, and runaway acceleration by parallel electric field. By introducing a wave that resonantly interacts with runaways at a particular range of energy that is mildly relativistic, the enhanced scattering would reshape the vortex by cutting off the part that is highly relativistic. The efficiency of resonant scattering accentuates the requirement that the wave amplitude can be small so the power requirement from external wave injection is practical for the mitigation scheme.

Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing

PubMed Central

Briard, Jennie G.; Poisson, Jessica S.; Turner, Tracey R.; Capicciotti, Chantelle J.; Acker, Jason P.; Ben, Robert N.

2016-01-01

During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol function by a number of different mechanisms but do not mitigate or control ice recrystallization at concentrations utilized in cryopreservation procedures. In North America, cryopreservation of human red blood cells (RBCs) utilizes high concentrations of glycerol. RBC units frozen under these conditions must be subjected to a time-consuming deglycerolization process after thawing in order to remove the glycerol to <1% prior to transfusion thus limiting the use of frozen RBC units in emergency situations. We have identified several low molecular mass ice recrystallization inhibitors (IRIs) that are effective cryoprotectants for human RBCs, resulting in 70–80% intact RBCs using only 15% glycerol and slow freezing rates. These compounds are capable of reducing the average ice crystal size of extracellular ice relative to a 15% glycerol control validating the positive correlation between a reduction in ice crystal size and increased post-thaw recovery of RBCs. The most potent IRI from this study is also capable of protecting frozen RBCs against the large temperature fluctuations associated with transient warming. PMID:27021850

Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing.

PubMed

Briard, Jennie G; Poisson, Jessica S; Turner, Tracey R; Capicciotti, Chantelle J; Acker, Jason P; Ben, Robert N

2016-03-29

During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol function by a number of different mechanisms but do not mitigate or control ice recrystallization at concentrations utilized in cryopreservation procedures. In North America, cryopreservation of human red blood cells (RBCs) utilizes high concentrations of glycerol. RBC units frozen under these conditions must be subjected to a time-consuming deglycerolization process after thawing in order to remove the glycerol to <1% prior to transfusion thus limiting the use of frozen RBC units in emergency situations. We have identified several low molecular mass ice recrystallization inhibitors (IRIs) that are effective cryoprotectants for human RBCs, resulting in 70-80% intact RBCs using only 15% glycerol and slow freezing rates. These compounds are capable of reducing the average ice crystal size of extracellular ice relative to a 15% glycerol control validating the positive correlation between a reduction in ice crystal size and increased post-thaw recovery of RBCs. The most potent IRI from this study is also capable of protecting frozen RBCs against the large temperature fluctuations associated with transient warming.

Current techniques in acid-chloride corrosion control and monitoring at The Geysers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirtz, Paul; Buck, Cliff; Kunzman, Russell

1991-01-01

Acid chloride corrosion of geothermal well casings, production piping and power plant equipment has resulted in costly corrosion damage, frequent curtailments of power plants and the permanent shut-in of wells in certain areas of The Geysers. Techniques have been developed to mitigate these corrosion problems, allowing continued production of steam from high chloride wells with minimal impact on production and power generation facilities.The optimization of water and caustic steam scrubbing, steam/liquid separation and process fluid chemistry has led to effective and reliable corrosion mitigation systems currently in routine use at The Geysers. When properly operated, these systems can yield steammore » purities equal to or greater than those encountered in areas of The Geysers where chloride corrosion is not a problem. Developments in corrosion monitoring techniques, steam sampling and analytical methodologies for trace impurities, and computer modeling of the fluid chemistry has been instrumental in the success of this technology.« less

Impacts of climate mitigation strategies in the energy sector on global land use and carbon balance

NASA Astrophysics Data System (ADS)

Engström, Kerstin; Lindeskog, Mats; Olin, Stefan; Hassler, John; Smith, Benjamin

2017-09-01

Reducing greenhouse gas emissions to limit damage to the global economy climate-change-induced and secure the livelihoods of future generations requires ambitious mitigation strategies. The introduction of a global carbon tax on fossil fuels is tested here as a mitigation strategy to reduce atmospheric CO2 concentrations and radiative forcing. Taxation of fossil fuels potentially leads to changed composition of energy sources, including a larger relative contribution from bioenergy. Further, the introduction of a mitigation strategy reduces climate-change-induced damage to the global economy, and thus can indirectly affect consumption patterns and investments in agricultural technologies and yield enhancement. Here we assess the implications of changes in bioenergy demand as well as the indirectly caused changes in consumption and crop yields for global and national cropland area and terrestrial biosphere carbon balance. We apply a novel integrated assessment modelling framework, combining three previously published models (a climate-economy model, a socio-economic land use model and an ecosystem model). We develop reference and mitigation scenarios based on the narratives and key elements of the shared socio-economic pathways (SSPs). Taking emissions from the land use sector into account, we find that the introduction of a global carbon tax on the fossil fuel sector is an effective mitigation strategy only for scenarios with low population development and strong sustainability criteria (SSP1 Taking the green road). For scenarios with high population growth, low technological development and bioenergy production the high demand for cropland causes the terrestrial biosphere to switch from being a carbon sink to a source by the end of the 21st century.

System and method for laser-based, non-evaporative repair of damage sites in the surfaces of fused silica optics

DOEpatents

Adams, John J.; Bolourchi, Masoud; Bude, Jeffrey D.; Guss, Gabriel M.; Jarboe, Jeffery A.; Matthews, Manyalibo J.; Nostrand, Michael C; Wegner, Paul J.

2016-09-06

A method for repairing a damage site on a surface of an optical material is disclosed. The method may involve focusing an Infrared (IR) laser beam having a predetermined wavelength, with a predetermined beam power, to a predetermined full width ("F/W") 1/e.sup.2 diameter spot on the damage site. The focused IR laser beam is maintained on the damage site for a predetermined exposure period corresponding to a predetermined acceptable level of downstream intensification. The focused IR laser beam heats the damage site to a predetermined peak temperature, which melts and reflows material at the damage site of the optical material to create a mitigated site.

Structural Load Alleviation Applied to Next Generation Aircraft and Wind Turbines

NASA Technical Reports Server (NTRS)

Frost, Susan

2011-01-01

Reducing the environmental impact of aviation is a goal of the Subsonic Fixed Wing Project under the Fundamental Aeronautics Program of NASAs Aeronautics Research Mission Directorate. Environmental impact of aviation is being addressed by novel aircraft configurations and materials that reduce aircraft weight and increase aerodynamic efficiency. NASA is developing tools to address the challenges of increased airframe flexibility created by wings constructed with reduced structural material and novel light-weight materials. This talk will present a framework and demonstration of a flight control system using optimal control allocation with structural load feedback and constraints to achieve safe aircraft operation. As wind turbines age, they become susceptible to many forms of blade degradation. Results will be presented on work in progress that uses adaptive contingency control for load mitigation in a wind turbine simulation with blade damage progression modeled.

44 CFR 201.4 - Standard State Mitigation Plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

... State owned or operated buildings, infrastructure, and critical facilities located in the identified... vulnerable to damage and loss associated with hazard events. State owned or operated critical facilities...

44 CFR 201.4 - Standard State Mitigation Plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... State owned or operated buildings, infrastructure, and critical facilities located in the identified... vulnerable to damage and loss associated with hazard events. State owned or operated critical facilities...

Use of QuakeSim and UAVSAR for Earthquake Damage Mitigation and Response

NASA Technical Reports Server (NTRS)

Donnellan, A.; Parker, J. W.; Bawden, G.; Hensley, S.

2009-01-01

Spaceborne, airborne, and modeling and simulation techniques are being applied to earthquake risk assessment and response for mitigation from this natural disaster. QuakeSim is a web-based portal for modeling interseismic strain accumulation using paleoseismic and crustal deformation data. The models are used for understanding strain accumulation and release from earthquakes as well as stress transfer to neighboring faults. Simulations of the fault system can be used for understanding the likelihood and patterns of earthquakes as well as the likelihood of large aftershocks from events. UAVSAR is an airborne L-band InSAR system for collecting crustal deformation data. QuakeSim, UAVSAR, and DESDynI (following launch) can be used for monitoring earthquakes, the associated rupture and damage, and postseismic motions for prediction of aftershock locations.

Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response

PubMed Central

Busch, Andrea W.U.; Montgomery, Beronda L.

2015-01-01

Tetrapyrroles are involved in light harvesting and light perception, electron-transfer reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in which cells exhibit stress-induced imbalances of photosynthetic reactions, or light absorption exceeds the ability of the cell to use photoexcitation energy in synthesis reactions, redox imbalance can occur in photosynthetic cells. Such conditions can lead to the generation of reactive oxygen species (ROS) associated with alterations in tetrapyrrole homeostasis. ROS accumulation can result in cellular damage and detrimental effects on organismal fitness, or ROS molecules can serve as signals to induce a protective or damage-mitigating oxidative stress signaling response in cells. Induced oxidative stress responses include tetrapyrrole-dependent and -independent mechanisms for mitigating ROS generation and/or accumulation. Thus, tetrapyrroles can be contributors to oxidative stress, but are also essential in the oxidative stress response to protect cells by contributing to detoxification of ROS. In this review, we highlight the interconnection and interdependence of tetrapyrrole metabolism with the occurrence of oxidative stress and protective oxidative stress signaling responses in photosynthetic organisms. PMID:25618582

Reactive nitrogen requirements to feed the world in 2050 and potential to mitigate nitrogen pollution.

PubMed

Bodirsky, Benjamin Leon; Popp, Alexander; Lotze-Campen, Hermann; Dietrich, Jan Philipp; Rolinski, Susanne; Weindl, Isabelle; Schmitz, Christoph; Müller, Christoph; Bonsch, Markus; Humpenöder, Florian; Biewald, Anne; Stevanovic, Miodrag

2014-05-13

Reactive nitrogen (Nr) is an indispensable nutrient for agricultural production and human alimentation. Simultaneously, agriculture is the largest contributor to Nr pollution, causing severe damages to human health and ecosystem services. The trade-off between food availability and Nr pollution can be attenuated by several key mitigation options, including Nr efficiency improvements in crop and animal production systems, food waste reduction in households and lower consumption of Nr-intensive animal products. However, their quantitative mitigation potential remains unclear, especially under the added pressure of population growth and changes in food consumption. Here we show by model simulations, that under baseline conditions, Nr pollution in 2050 can be expected to rise to 102-156% of the 2010 value. Only under ambitious mitigation, does pollution possibly decrease to 36-76% of the 2010 value. Air, water and atmospheric Nr pollution go far beyond critical environmental thresholds without mitigation actions. Even under ambitious mitigation, the risk remains that thresholds are exceeded.

Ischemic and oxidative damage to the hypothalamus may be responsible for heat stroke.

PubMed

Chen, Sheng-Hsien; Lin, Mao-Tsun; Chang, Ching-Ping

2013-03-01

The hypothalamus may be involved in regulating homeostasis, motivation, and emotional behavior by controlling autonomic and endocrine activity. The hypothalamus communicates input from the thalamus to the pituitary gland, reticular activating substance, limbic system, and neocortex. This allows the output of pituitary hormones to respond to changes in autonomic nervous system activity. Environmental heat stress increases cutaneous blood flow and metabolism, and progressively decreases splanchnic blood flow. Severe heat exposure also decreases mean arterial pressure (MAP), increases intracranial pressure (ICP), and decreases cerebral perfusion pressure (CPP = MAP - ICP), all of which lead to cerebral ischemia and hypoxia. Compared with normothermic controls, rodents with heatstroke have higher hypothalamic values of cellular ischemia (e.g., glutamate and lactate-to-pyruvate ratio) and damage (e.g., glycerol) markers, pro-oxidant enzymes (e.g., lipid peroxidation and glutathione oxidation), proinflammatory cytokines (e.g., interleukin-1β and tumor necrosis factor-α), inducible nitric oxide synthase-dependent nitric oxide, and an indicator for the accumulation of polymorphonuclear leukocytes (e.g., myeloperoxidase activity), as well as neuronal damage (e.g., apoptosis, necrosis, and autophagy) after heatstroke. Hypothalamic values of antioxidant defenses (e.g., glutathione peroxidase and glutathione reductase), however, are lower. The ischemic, hypoxic, and oxidative damage to the hypothalamus during heatstroke may cause multiple organ dysfunction or failure through hypothalamic-pituitary-adrenal axis mechanisms. Finding the link between the signaling and heatstroke-induced hypothalamic oxidative and ischemic damage might allow us to clinically attenuate heatstroke. In particular, free radical scavengers, heat shock protein-70 inducers, hypervolemic hemodilution, inducible nitric oxide synthase inhibitors, progenitor stem cells, flutamide, estrogen, interleukin-1 receptor antagonists, glucocorticoid, activated protein C, and baicalin mitigate preclinical heatstroke levels.

Northridge 20 Symposium

Science.gov Websites

billion in direct damage. The event spurred important changes to the current practice of earthquake engineering and risk mitigation worldwide, including changes to building codes for steel structures and multi

Global patterns and trends in human-wildlife conflict compensation.

PubMed

Ravenelle, Jeremy; Nyhus, Philip J

2017-12-01

Human-wildlife conflict is a major conservation challenge, and compensation for wildlife damage is a widely used economic tool to mitigate this conflict. The effectiveness of this management tool is widely debated. The relative importance of factors associated with compensation success is unclear, and little is known about global geographic or taxonomic differences in the application of compensation programs. We reviewed research on wildlife-damage compensation to determine geographic and taxonomic gaps, analyze patterns of positive and negative comments related to compensation, and assess the relative magnitude of global compensation payments. We analyzed 288 publications referencing wildlife compensation and identified 138 unique compensation programs. These publications reported US$222 million (adjusted for inflation) spent on compensation in 50 countries since 1980. Europeans published the most articles, and compensation funding was highest in Europe, where depredation by wolves and bears was the most frequently compensated damage. Authors of the publications we reviewed made twice as many negative comments as positive comments about compensation. Three-quarters of the negative comments related to program administration. Conversely, three-quarters of the positive comments related to program outcomes. The 3 most common suggestions to improve compensation programs included requiring claimants to employ damage-prevention practices, such as improving livestock husbandry or fencing of crops to receive compensation (n = 25, 15%); modifying ex post compensation schemes to some form of outcome-based performance payment (n = 21, 12%); and altering programs to make compensation payments more quickly (n = 14, 8%). We suggest that further understanding of the strengths and weaknesses of compensation as a conflict-mitigation tool will require more systematic evaluation of the factors driving these opinions and that differentiating process and outcomes and understanding linkages between them will result in more fruitful analyses and ultimately more effective conflict mitigation. © 2017 Society for Conservation Biology.

Burden Sharing with Climate Change Impacts

NASA Astrophysics Data System (ADS)

Tavoni, M.; van Vuuren, D.; De Cian, E.; Marangoni, G.; Hof, A.

2014-12-01

Efficiency and equity have been at the center of the climate change policy making since the very first international environmental agreements on climate change, though over time how to implement these principles has taken different forms. Studies based on Integrated Assessment Models have also shown that the economic effort of achieving a 2 degree target in a cost-effective way would differ widely across regions (Tavoni et al. 2013) because of diverse economic and energy structure, baseline emissions, energy and carbon intensity. Policy instruments, such as a fully-fledged, global emission trading schemes can be used to pursuing efficiency and equity at the same time but the literature has analyzed the compensations required to redistribute only mitigation costs. However, most of these studies have neglected the potential impacts of climate change. In this paper we use two integrated assessment models -FAIR and WITCH- to explore the 2°C policy space when accounting for climate change impacts. Impacts are represented via two different reduced forms equations, which despite their simplicity allows us exploring the key sensitivities- Our results show that in a 2 degree stabilization scenarios residual damages remain significant (see Figure 1) and that if you would like to compensate those as part of an equal effort scheme - this would lead to a different allocation than focusing on a mitigation based perspective only. The residual damages and adaptation costs are not equally distributed - and while we do not cover the full uncertainty space - with 2 different models and 2 sets of damage curves we are still able to show quite similar results in terms of vulnerable regions and the relative position of the different scenarios. Therefore, accounting for the residual damages and the associated adaptation costs on top of the mitigation burden increases and redistributes the full burden of total climate change.

Overview of landslide problems, research, and mitigation, Cincinnati, Ohio, area

USGS Publications Warehouse

Baum, Rex L.; Johnson, Arvid M.

1996-01-01

Landslides cause much damage to property throughout the metropolitan area of Cincinnati, Ohio. Most landslides occur in unconsolidated deposits, including colluvium, till, glacial lake clays, and man-made fill derived from colluvium and glacial deposits. Landslides in thin colluvium are widespread on steeper slopes that wall the valleys of the Ohio River and its tributaries. Abundant landslides also form in thick colluvium on flatter slopes, especially where the colluvium has been disturbed by earthwork. Unusual block glides and block-extrusion glides form where till rests on lake clay. Through the years, knowledge of the distribution and causes of landslides has increased as a result of many investigations. This knowledge became part of the basis for landslide mitigation programs adopted by the City of Cincinnati and Hamilton County, Ohio. In 1974 the Cincinnati City Council passed an excavation and fill ordinance to help reduce landslide damage in areas of new construction. In 1989 following much additional study, Cincinnati created a geotechnical office within its Department of Public Works. The office, which is staffed by a geotechnical engineer, an engineering geologist, and two technicians, carries out a mitigation program. Since 1989, members of the geotechnical staff have worked in several ways to reduce landslide damage in the city; their work includes engineering-geologic mapping of selected parts of the city, inspection of retaining walls that impact public right-of-way, review of proposed construction in hillside areas, inspecting and arranging for repair of landslide areas that affect city property, and compiling geologic and geotechnical data on landslide areas within the city. In 1990, Hamilton County also adopted an excavation and fill ordinance to help reduce the damage due to landslides in areas of new construction.

Polymer damage mitigation---predictive lifetime models of polymer insulation degradation and biorenewable thermosets through cationic polymerization for self-healing applications

NASA Astrophysics Data System (ADS)

Hondred, Peter Raymond

Over the past 50 years, the industrial development and applications for polymers and polymer composites has become expansive. However, as with any young technology, the techniques for predicting material damage and resolving material failure are in need of continued development and refinement. This thesis work takes two approaches to polymer damage mitigation---material lifetime prediction and spontaneous damage repair through self-healing while incorporating bio-renewable feedstock. First, material lifetime prediction offers the benefit of identifying and isolating material failures before the effects of damage results in catastrophic failure. Second, self-healing provides a systematic approach to repairing damaged polymer composites, specifically in applications where a hands-on approach or removing the part from service are not feasible. With regard to lifetime prediction, we investigated three specific polymeric materials---polytetrafluoroethylene (PTFE), poly(ethylene-alt-tetrafluoroethylene) (ETFE), and Kapton. All three have been utilized extensively in the aerospace field as a wire insulation coating. Because of the vast amount of electrical wiring used in aerospace constructions and the potential for electrical and thermal failure, this work develops mathematical models for both the thermal degradation kinetics as well as a lifetime prediction model for electrothermal breakdown. Isoconversional kinetic methods, which plot activation energy as a function of the extent of degradation, present insight into the development each kinetic model. The models for PTFE, ETFE, and Kapton are one step, consecutive three-step, and competitive and consecutive five-step respectively. Statistical analysis shows that an nth order autocatalytic reaction best defined the reaction kinetics for each polymer's degradation. Self-healing polymers arrest crack propagation through the use of an imbedded adhesive that reacts when cracks form. This form of damage mitigation focuses on repairing damage before the damage causes a failure in the polymer's function. In this work, the healing agent (adhesive) is developed using bio-renewable oils instead of solely relying on petroleum based feedstocks. Several bio-renewable thermosetting polymers were successfully prepared from tung oil through cationic polymerization for the use as the healing agent in self-healing microencapsulated applications. Modifications to both the monomers in the resin and the catalyst for polymerization were made and the subsequent changes to mechanical, thermal, and structural properties were identified. Furthermore, compressive lap shear testing was used to confirm that the adhesive properties would be beneficial for self-healing applications. Finally, scanning electron microscopy of the crack plane was used to study the fracture mechanism of the crack.

Use of Citizen Science and Social Media to Improve Wind Hazard and Damage Characterization

NASA Astrophysics Data System (ADS)

Lombardo, F.; Meidani, H.

2017-12-01

Windstorm losses are significant in the U.S. annually and cause damage worldwide. A large percentage of losses are caused by localized events (e.g., tornadoes). In order to better mitigate these losses improvement is needed in understanding the hazard characteristics and physical damage. However, due to the small-scale nature of these events the resolution of the dedicated measuring network does not capture most occurrences. As a result damage-based assessments are sometimes used to gauge intensity. These damage assessments often suffer from a lack of available manpower, inability to arrive at the scene rapidly and difficulty accessing a damaged site. The use and rapid dissemination of social media, the power of crowds engaged in scientific endeavors, and the public's awareness of their vulnerabilities point to a paradigm shift in how hazards can be sensed in a rapid manner. In this way, `human-sensor' data has the potential to radically improve fundamental understanding of hazard and disasters and resolve some of the existing challenges in wind hazard and damage characterization. Data from social media outlets such as Twitter have been used to aid in damage assessments from hazards such as flood and earthquake, however, the reliability and uncertainty of participatory sensing has been questioned and has been called the `biggest challenge' for its sustained use. This research proposes to investigate the efficacy of both citizen science applications and social media data to represent wind hazards and associated damage. Research has focused on a two-phase approach: 1) to have citizen scientists perform their own `damage survey' (i.e., questionnaire) with known damage to assess uncertainty in estimation and 2) downloading and analysis of social media text and imagery streams to ascertain the possibility of performing `unstructured damage surveys'. Early results have shown that the untrained public can estimate tornado damage levels in residential structures with some accuracy. In addition, valuable windstorm hazard and damage information in both text and imagery can be extracted and archived from Twitter in an automated fashion. Information extracted from these sources will feed into advances in hazard and disaster modeling, social-cognitive theories of human behavior and decision-making for hazard mitigation.

The characteristic of the building damage from historical large earthquakes in Kyoto

NASA Astrophysics Data System (ADS)

Nishiyama, Akihito

2016-04-01

The Kyoto city, which is located in the northern part of Kyoto basin in Japan, has a long history of >1,200 years since the city was initially constructed. The city has been a populated area with many buildings and the center of the politics, economy and culture in Japan for nearly 1,000 years. Some of these buildings are now subscribed as the world's cultural heritage. The Kyoto city has experienced six damaging large earthquakes during the historical period: i.e., in 976, 1185, 1449, 1596, 1662, and 1830. Among these, the last three earthquakes which caused severe damage in Kyoto occurred during the period in which the urban area had expanded. These earthquakes are considered to be inland earthquakes which occurred around the Kyoto basin. The damage distribution in Kyoto from historical large earthquakes is strongly controlled by ground condition and earthquakes resistance of buildings rather than distance from estimated source fault. Therefore, it is necessary to consider not only the strength of ground shaking but also the condition of building such as elapsed years since the construction or last repair in order to more accurately and reliably estimate seismic intensity distribution from historical earthquakes in Kyoto. The obtained seismic intensity map would be helpful for reducing and mitigating disaster from future large earthquakes.

What Are Teachers' Opinions about Including Topics of Natural Events and Their Risks in Primary Curriculum in Kocaeli (Turkey)?

ERIC Educational Resources Information Center

Bulus Kirikkaya, Esma; Imali, Beyza

2013-01-01

Community awareness must be increased for communities to play an effective role in the mitigation of disaster damage. Education is the most effective way to accomplish this. It is important for people to know that even though they cannot intervene or prevent such events, they can take precautionary measures to reduce the damage caused by…

Utility and Value of Satellite-Based Frost Forecasting for Kenya's Tea Farming Sector

NASA Astrophysics Data System (ADS)

Morrison, I.

2016-12-01

Frost damage regularly inflicts millions of dollars of crop losses in the tea-growing highlands of western Kenya, a problem that the USAID/NASA Regional Visualization and Monitoring System (SERVIR) program is working to mitigate through a frost monitoring and forecasting product that uses satellite-based temperature and soil moisture data to generate up to three days of advanced warning before frost events. This paper presents the findings of a value of information (VOI) study assessing the value of this product based on Kenyan tea farmers' experiences with frost and frost-damage mitigation. Value was calculated based on historic trends of frost frequency, severity, and extent; likelihood of warning receipt and response; and subsequent frost-related crop-loss aversion. Quantification of these factors was derived through inferential analysis of survey data from 400 tea-farming households across the tea-growing regions of Kericho and Nandi, supplemented with key informant interviews with decision-makers at large estate tea plantations, historical frost incident and crop-loss data from estate tea plantations and agricultural insurance companies, and publicly available demographic and economic data. At this time, the product provides a forecasting window of up to three days, and no other frost-prediction methods are used by the large or small-scale farmers of Kenya's tea sector. This represents a significant opportunity for preemptive loss-reduction via Earth observation data. However, the tea-growing community has only two realistic options for frost-damage mitigation: preemptive harvest of available tea leaves to minimize losses, or skiving (light pruning) to facilitate fast recovery from frost damage. Both options are labor-intensive and require a minimum of three days of warning to be viable. As a result, the frost forecasting system has a very narrow margin of usefulness, making its value highly dependent on rapid access to the warning messages and flexible access to harvesting labor for mitigation activities. These findings show that the Frost monitoring product has the potential for real monetary benefit to members of the frost-vulnerable tea growing community but realization of that value needs direct collaboration with the tea-farming community to ensure effective product utilization.

Flood damage: a model for consistent, complete and multipurpose scenarios

NASA Astrophysics Data System (ADS)

Menoni, Scira; Molinari, Daniela; Ballio, Francesco; Minucci, Guido; Mejri, Ouejdane; Atun, Funda; Berni, Nicola; Pandolfo, Claudia

2016-12-01

Effective flood risk mitigation requires the impacts of flood events to be much better and more reliably known than is currently the case. Available post-flood damage assessments usually supply only a partial vision of the consequences of the floods as they typically respond to the specific needs of a particular stakeholder. Consequently, they generally focus (i) on particular items at risk, (ii) on a certain time window after the occurrence of the flood, (iii) on a specific scale of analysis or (iv) on the analysis of damage only, without an investigation of damage mechanisms and root causes. This paper responds to the necessity of a more integrated interpretation of flood events as the base to address the variety of needs arising after a disaster. In particular, a model is supplied to develop multipurpose complete event scenarios. The model organizes available information after the event according to five logical axes. This way post-flood damage assessments can be developed that (i) are multisectoral, (ii) consider physical as well as functional and systemic damage, (iii) address the spatial scales that are relevant for the event at stake depending on the type of damage that has to be analyzed, i.e., direct, functional and systemic, (iv) consider the temporal evolution of damage and finally (v) allow damage mechanisms and root causes to be understood. All the above features are key for the multi-usability of resulting flood scenarios. The model allows, on the one hand, the rationalization of efforts currently implemented in ex post damage assessments, also with the objective of better programming financial resources that will be needed for these types of events in the future. On the other hand, integrated interpretations of flood events are fundamental to adapting and optimizing flood mitigation strategies on the basis of thorough forensic investigation of each event, as corroborated by the implementation of the model in a case study.

High-Resolution Methods for Diagnosing Cartilage Damage In Vivo

PubMed Central

Novakofski, Kira D.; Pownder, Sarah L.; Koff, Matthew F.; Williams, Rebecca M.; Potter, Hollis G.; Fortier, Lisa A.

2016-01-01

Advances in current clinical modalities, including magnetic resonance imaging and computed tomography, allow for earlier diagnoses of cartilage damage that could mitigate progression to osteoarthritis. However, current imaging modalities do not detect submicrometer damage. Developments in in vivo or arthroscopic techniques, including optical coherence tomography, ultrasonography, bioelectricity including streaming potential measurement, noninvasive electroarthrography, and multiphoton microscopy can detect damage at an earlier time point, but they are limited by a lack of penetration and the ability to assess an entire joint. This article reviews current advancements in clinical and developing modalities that can aid in the early diagnosis of cartilage injury and facilitate studies of interventional therapeutics. PMID:26958316

Modeling electrical power absorption and thermally-induced biological tissue damage.

PubMed

Zohdi, T I

2014-01-01

This work develops a model for thermally induced damage from high current flow through biological tissue. Using the first law of thermodynamics, the balance of energy produced by the current and the energy absorbed by the tissue are investigated. The tissue damage is correlated with an evolution law that is activated upon exceeding a temperature threshold. As an example, the Fung material model is used. For certain parameter choices, the Fung material law has the ability to absorb relatively significant amounts of energy, due to its inherent exponential response character, thus, to some extent, mitigating possible tissue damage. Numerical examples are provided to illustrate the model's behavior.

The new design of final optics assembly on SG-III prototype facility

NASA Astrophysics Data System (ADS)

Li, Ping; Zhao, Runchang; Wang, Wei; Jia, Huaiting; Chen, Liangmin; Su, Jingqin

2014-09-01

To improve the performance of SG-III prototype facility (TIL-Technical Integration Line), final optics assembly (FOA) is re-designed. It contains that stray light and focusing ghosts are optimized, operational performance and environments are improved and the total thickness of optics is reduced. With the re-designed FOA, Some performance advantages are achieved. First, the optics damages are mitigated obviously, especially crystals and Focus lens; Second, stray light and focusing ghosts are controlled better that organic contamination sources inside FOA are eliminated; Third, maintenance and operation are more convenient for the atoms environment; Fourth, the focusable power on target is increased for lower B-integral.

CO2 laser and plasma microjet process for improving laser optics

DOEpatents

Brusasco, Raymond M.; Penetrante, Bernardino M.; Butler, James A.; Grundler, Walter; Governo, George K.

2003-09-16

A optic is produced for operation at the fundamental Nd:YAG laser wavelength of 1.06 micrometers through the tripled Nd:YAG laser wavelength of 355 nanometers by the method of reducing or eliminating the growth of laser damage sites in the optics by processing the optics to stop damage in the optics from growing to a predetermined critical size. A system is provided of mitigating the growth of laser-induced damage in optics by virtue of very localized removal of glass and absorbing material.

Stream stability at highway structures.

DOT National Transportation Integrated Search

1995-11-01

This document provides guidelines for identifying stream instability problems at highway stream crossings and for the selection and design of appropriate countermeasures to mitigate potential damages to bridges and other highway components at stream ...

Proposed health state awareness of helicopter blades using an artificial neural network strategy

NASA Astrophysics Data System (ADS)

Lee, Andrew; Habtour, Ed; Gadsden, S. A.

2016-05-01

Structural health prognostics and diagnosis strategies can be classified as either model or signal-based. Artificial neural network strategies are popular signal-based techniques. This paper proposes the use of helicopter blades in order to study the sensitivity of an artificial neural network to structural fatigue. The experimental setup consists of a scale aluminum helicopter blade exposed to transverse vibratory excitation at the hub using single axis electrodynamic shaker. The intent of this study is to optimize an algorithm for processing high-dimensional data while retaining important information content in an effort to select input features and weights, as well as health parameters, for training a neural network. Data from accelerometers and piezoelectric transducers is collected from a known system designated as healthy. Structural damage will be introduced to different blades, which they will be designated as unhealthy. A variety of different tests will be performed to track the evolution and severity of the damage. A number of damage detection and diagnosis strategies will be implemented. A preliminary experiment was performed on aluminum cantilever beams providing a simpler model for implementation and proof of concept. Future work will look at utilizing the detection information as part of a hierarchical control system in order to mitigate structural damage and fatigue. The proposed approach may eliminate massive data storage on board of an aircraft through retaining relevant information only. The control system can then employ the relevant information to intelligently reconfigure adaptive maneuvers to avoid harmful regimes, thus, extending the life of the aircraft.

Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain.

PubMed

Yang, Ruimeng; Duan, Chong; Yuan, Liya; Engelbach, John A; Tsien, Christina I; Beeman, Scott C; Perez-Torres, Carlos J; Ge, Xia; Rich, Keith M; Ackerman, Joseph J H; Garbow, Joel R

2018-03-15

There is mounting evidence that, in addition to angiogenesis, hypoxia-induced inflammation via the hypoxia-inducible factor 1α (HIF-1α)-CXC chemokine receptor 4 (CXCR4) pathway may contribute to the pathogenesis of late-onset, irradiation-induced necrosis. This study investigates the mitigative efficacy of an HIF-1α inhibitor, topotecan, and a CXCR4 antagonist, AMD3100, on the development of radiation necrosis (RN) in an intracranial mouse model. Mice received a single-fraction, 50-Gy dose of hemispheric irradiation from the Leksell Gamma Knife Perfexion and were then treated with either topotecan, an HIF-1α inhibitor, from 1 to 12 weeks after irradiation, or AMD3100, a CXCR4 antagonist, from 4 to 12 weeks after irradiation. The onset and progression of RN were monitored longitudinally via noninvasive, in vivo magnetic resonance imaging (MRI) from 4 to 12 weeks after irradiation. Conventional hematoxylin-eosin staining and immunohistochemistry staining were performed to evaluate the treatment response. The progression of brain RN was significantly mitigated for mice treated with either topotecan or AMD3100 compared with control animals. MRI-derived lesion volumes were significantly smaller for both of the treated groups, and histologic findings correlated well with the MRI data. By hematoxylin-eosin staining, both treated groups demonstrated reduced irradiation-induced tissue damage compared with controls. Furthermore, immunohistochemistry results revealed that expression levels of vascular endothelial growth factor, CXC chemokine ligand 12, CD68, CD3, and tumor necrosis factor α in the lesion area were significantly lower in treated (topotecan or AMD3100) brains versus control brains, while ionized calcium-binding adapter molecule 1 (Iba1) and HIF-1α expression was similar, though somewhat reduced. CXCR4 expression was reduced only in topotecan-treated mice, while interleukin 6 expression was unaffected by either topotecan or AMD3100. By reducing inflammation, both topotecan and AMD3100 can, independently, mitigate the development of RN in the mouse brain. When combined with first-line, antiangiogenic treatment, anti-inflammation therapy may provide an adjuvant therapeutic strategy for clinical, postirradiation management of tumors, with additional benefits in the mitigation of RN development. Copyright © 2017 Elsevier Inc. All rights reserved.

Low-cost rural surface alternatives : demonstration project : [tech transfer summary].

DOT National Transportation Integrated Search

2015-06-01

Identify the most effective and economical methods for preventing or : mitigating freeze-thaw damage to granular surfaced roads in seasonally : cold regions : Construct demonstration test sections using several stabilization : methods recomme...

OPTIMIZATION OF EXPERIMENTAL DESIGNS BY INCORPORATING NIF FACILITY IMPACTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eder, D C; Whitman, P K; Koniges, A E

2005-08-31

For experimental campaigns on the National Ignition Facility (NIF) to be successful, they must obtain useful data without causing unacceptable impact on the facility. Of particular concern is excessive damage to optics and diagnostic components. There are 192 fused silica main debris shields (MDS) exposed to the potentially hostile target chamber environment on each shot. Damage in these optics results either from the interaction of laser light with contamination and pre-existing imperfections on the optic surface or from the impact of shrapnel fragments. Mitigation of this second damage source is possible by identifying shrapnel sources and shielding optics from them.more » It was recently demonstrated that the addition of 1.1-mm thick borosilicate disposable debris shields (DDS) block the majority of debris and shrapnel fragments from reaching the relatively expensive MDS's. However, DDS's cannot stop large, faster moving fragments. We have experimentally demonstrated one shrapnel mitigation technique showing that it is possible to direct fast moving fragments by changing the source orientation, in this case a Ta pinhole array. Another mitigation method is to change the source material to one that produces smaller fragments. Simulations and validating experiments are necessary to determine which fragments can penetrate or break 1-3 mm thick DDS's. Three-dimensional modeling of complex target-diagnostic configurations is necessary to predict the size, velocity, and spatial distribution of shrapnel fragments. The tools we are developing will be used to set the allowed level of debris and shrapnel generation for all NIF experimental campaigns.« less

Effects of calcium at toxic concentrations of cadmium in plants.

PubMed

Huang, Danlian; Gong, Xiaomin; Liu, Yunguo; Zeng, Guangming; Lai, Cui; Bashir, Hassan; Zhou, Lu; Wang, Dafei; Xu, Piao; Cheng, Min; Wan, Jia

2017-05-01

This review provides new insight that calcium plays important roles in plant growth, heavy metal accumulation and translocation, photosynthesis, oxidative damage and signal transduction under cadmium stress. Increasing heavy metal pollution problems have raised word-wide concerns. Cadmium (Cd), being a highly toxic metal, poses potential risks both to ecosystems and human health. Compared with conventional technologies, phytoremediation, being cost-efficient, highly stable and environment-friendly, is believed to be a promising green technology for Cd decontamination. However, Cd can be easily taken up by plants and may cause severe phytotoxicity to plants, thus limiting the efficiency of phytoremediation. Various researches are being done to investigate the effects of exogenous substances on the mitigation of Cd toxicity to plants. Calcium (Ca) is an essential plant macronutrient that involved in various plant physiological processes, such as plant growth and development, cell division, cytoplasmic streaming, photosynthesis and intracellular signaling transduction. Due to the chemical similarity between Ca and Cd, Ca may mediate Cd-induced physiological or metabolic changes in plants. Recent studies have shown that Ca could be used as an exogenous substance to protect plants against Cd stress by the alleviation of growth inhibition, regulation of metal uptake and translocation, improvement of photosynthesis, mitigation of oxidative damages and the control of signal transduction in the plants. The effects of Ca on toxic concentrations of Cd in plants are reviewed. This review also provides new insight that plants with enhanced Ca level have improved resistance to Cd stress.

Statistical Analysis of the Effectiveness of Seawalls and Coastal Forests in Mitigating Tsunami Impacts in Iwate and Miyagi Prefectures.

PubMed

Nateghi, Roshanak; Bricker, Jeremy D; Guikema, Seth D; Bessho, Akane

2016-01-01

The Pacific coast of the Tohoku region of Japan experiences repeated tsunamis, with the most recent events having occurred in 1896, 1933, 1960, and 2011. These events have caused large loss of life and damage throughout the coastal region. There is uncertainty about the degree to which seawalls reduce deaths and building damage during tsunamis in Japan. On the one hand they provide physical protection against tsunamis as long as they are not overtopped and do not fail. On the other hand, the presence of a seawall may induce a false sense of security, encouraging additional development behind the seawall and reducing evacuation rates during an event. We analyze municipality-level and sub-municipality-level data on the impacts of the 1896, 1933, 1960, and 2011 tsunamis, finding that seawalls larger than 5 m in height generally have served a protective role in these past events, reducing both death rates and the damage rates of residential buildings. However, seawalls smaller than 5 m in height appear to have encouraged development in vulnerable areas and exacerbated damage. We also find that the extent of flooding is a critical factor in estimating both death rates and building damage rates, suggesting that additional measures, such as multiple lines of defense and elevating topography, may have significant benefits in reducing the impacts of tsunamis. Moreover, the area of coastal forests was found to be inversely related to death and destruction rates, indicating that forests either mitigated the impacts of these tsunamis, or displaced development that would otherwise have been damaged.

Statistical Analysis of the Effectiveness of Seawalls and Coastal Forests in Mitigating Tsunami Impacts in Iwate and Miyagi Prefectures

PubMed Central

Nateghi, Roshanak; Bricker, Jeremy D.; Guikema, Seth D.; Bessho, Akane

2016-01-01

The Pacific coast of the Tohoku region of Japan experiences repeated tsunamis, with the most recent events having occurred in 1896, 1933, 1960, and 2011. These events have caused large loss of life and damage throughout the coastal region. There is uncertainty about the degree to which seawalls reduce deaths and building damage during tsunamis in Japan. On the one hand they provide physical protection against tsunamis as long as they are not overtopped and do not fail. On the other hand, the presence of a seawall may induce a false sense of security, encouraging additional development behind the seawall and reducing evacuation rates during an event. We analyze municipality-level and sub-municipality-level data on the impacts of the 1896, 1933, 1960, and 2011 tsunamis, finding that seawalls larger than 5 m in height generally have served a protective role in these past events, reducing both death rates and the damage rates of residential buildings. However, seawalls smaller than 5 m in height appear to have encouraged development in vulnerable areas and exacerbated damage. We also find that the extent of flooding is a critical factor in estimating both death rates and building damage rates, suggesting that additional measures, such as multiple lines of defense and elevating topography, may have significant benefits in reducing the impacts of tsunamis. Moreover, the area of coastal forests was found to be inversely related to death and destruction rates, indicating that forests either mitigated the impacts of these tsunamis, or displaced development that would otherwise have been damaged. PMID:27508461

An investigation of a reticulated foam - perforated steel sheet combination as a blast mitigation structure

NASA Astrophysics Data System (ADS)

Nguyen, Thuy-Tien N.; Proud, William G.

2017-01-01

Explosions are one of the main causes of injuries during battles and conflicts, with improvised explosive devices (IEDs) becoming increasingly common. Blast waves produced from such explosions can inflict very complex injuries on human and serious damage to structures. Here, the interaction between blast waves and sandwich structures of reticulated foam and perforated sheets is studied using a shock tube. The level of mitigation for primary blast injuries of these structures are discussed in terms of pulse shape, pressure magnitude and impulse. Schlieren photography and other high-speed imaging were used to capture the form of the blast wave. The results show up to 95% mitigation in both pressure and impulse with the structures studied. The behaviors of these mitigating sandwich panels under two loadings, Mach 2.0 and Mach 2.6, are also discussed.

Calculating and Mitigating the Risk of a Cut Glove to a Space Walking Astronaut

NASA Technical Reports Server (NTRS)

Castillo, Theresa; Haught, Megan

2013-01-01

One of the high risk operations on the International Space Station (ISS) is conducting a space walk, or an Extra Vehicular Activity (EVA). Threats to the space walking crew include airlock failures, space suit failures, and strikes from micro ]meteoroids and orbital debris (MM/OD). There are risks of becoming untethered from the space station, being pinched between the robotic arm and a piece of equipment, tearing your suit on a sharp edge, and other human errors that can be catastrophic. For decades NASA identified and tried to control sharp edges on external structure and equipment by design; however a new and unexpected source of sharp edges has since become apparent. Until recently, one of the underappreciated environmental risks was damage to EVA gloves during a spacewalk. The ISS has some elements which have been flying in the environment of space for over 14 years. It has and continues to be bombarded with MM/OD strikes that have created small, sharp craters all over the structure, including the dedicated EVA handrails and surrounding structure. These craters are capable of cutting through several layers of the EVA gloves. Starting in 2006, five EVA crewmembers reported cuts in their gloves so large they rendered the gloves unusable and in some cases cut the spacewalk short for the safety of the crew. This new hazard took engineers and managers by surprise. NASA has set out to mitigate this risk to safety and operations by redesigning the spacesuit gloves to be more resilient and designing a clamp to isolate MM/OD strikes on handrails, and is considering the necessity of an additional tool to repair strikes on non ]handrail surfaces (such as a file). This paper will address how the ISS Risk Team quantified an estimate of the MM/OD damage to the ISS, and the resulting likelihood of sustaining a cut glove in order to measure the effectiveness of the solutions being investigated to mitigate this risk to the mission and crew.

Effects of optimism on recovery and mental health after a tornado outbreak.

PubMed

Carbone, Eric G; Echols, Erin Thomas

2017-05-01

Dispositional optimism, a stable expectation that good things will happen, has been shown to improve health outcomes in a wide range of contexts, but very little research has explored the impact of optimism on post-disaster health and well-being. Data for this study come from the Centers for Disease Control and Prevention's Public health systems and mental health community recovery (PHSMHCR) Survey. Participants included 3216 individuals living in counties affected by the April 2011 tornado outbreak in Mississippi and Alabama. This study assesses the effect of dispositional optimism on post-disaster recovery and mental health. Dispositional optimism was found to have a positive effect on personal recovery and mental health after the disaster. Furthermore, it moderated the relationship between level of home damage and personal recovery as well as the relationship between home damage and post-traumatic stress disorder (PTSD), with stronger effects for those with increased levels of home damage. The utility of screening for optimism is discussed, along with the potential for interventions to increase optimism as a means of mitigating adverse mental health effects and improving the recovery of individuals affected by disasters and other traumatic events.

Effects of optimism on recovery and mental health after a tornado outbreak

PubMed Central

Carbone, Eric G.; Echols, Erin Thomas

2017-01-01

Objective Dispositional optimism, a stable expectation that good things will happen, has been shown to improve health outcomes in a wide range of contexts, but very little research has explored the impact of optimism on post-disaster health and well-being. Design Data for this study come from the Centers for Disease Control and Prevention’s Public health systems and mental health community recovery (PHSMHCR) Survey. Participants included 3216 individuals living in counties affected by the April 2011 tornado outbreak in Mississippi and Alabama. Main outcome measures This study assesses the effect of dispositional optimism on post-disaster recovery and mental health. Results Dispositional optimism was found to have a positive effect on personal recovery and mental health after the disaster. Furthermore, it moderated the relationship between level of home damage and personal recovery as well as the relationship between home damage and post-traumatic stress disorder (PTSD), with stronger effects for those with increased levels of home damage. Conclusions The utility of screening for optimism is discussed, along with the potential for interventions to increase optimism as a means of mitigating adverse mental health effects and improving the recovery of individuals affected by disasters and other traumatic events. PMID:28156138

Applying Genomic and Genetic Tools to Understand and Mitigate Damage from Exposure to Toxins

DTIC Science & Technology

2013-10-01

sequences to the human genome . Genome Biol 10, R25 (2009). 26 Award number: W81XWH-09-1-0715 Title: Applying Genomic and Genetic Tools to Understand...utilizing the high-throughput technology of mRNA-seq. BODY The goal of our research program (W81XWH-09-1-0715) was to utilize genetic and genomic ...also acquired the achetf222a * * * * * 5 Award number: W81XWH-09-1-0715 Title: Applying Genomic and Genetic Tools to Understand and Mitigate

Combining Hydrological Modeling and Remote Sensing Observations to Enable Data-Driven Decision Making for Devils Lake Flood Mitigation in a Changing Climate

NASA Technical Reports Server (NTRS)

Zhang, Xiaodong; Kirilenko, Andrei; Lim, Howe; Teng, Williams

2010-01-01

This slide presentation reviews work to combine the hydrological models and remote sensing observations to monitor Devils Lake in North Dakota, to assist in flood damage mitigation. This reports on the use of a distributed rainfall-runoff model, HEC-HMS, to simulate the hydro-dynamics of the lake watershed, and used NASA's remote sensing data, including the TRMM Multi-Satellite Precipitation Analysis (TMPA) and AIRS surface air temperature, to drive the model.

Repair of the Czar Shaft sinkhole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deatherage, J.D.; Starkey, J.; Gustavson, N.

1996-12-31

After a Portion of the Queen Mine parking lot collapsed into a sinkhole, an engineering study was conducted to confirm that the cause of the damage was settlement into the Czar Shaft in Bisbee, Arizona. Historical records were researched to describe and locate the original shaft, and a seismic refraction survey was performed to define the foundation conditions within and around the shaft. Recommended mitigation measures were developed to repair the parking lot. Mitigation included design and construction of a flexible geosynthetic cap and telltale settlement monitoring system.

Interactive Web-based Floodplain Simulation System for Realistic Experiments of Flooding and Flood Damage

NASA Astrophysics Data System (ADS)

Demir, I.

2013-12-01

Recent developments in web technologies make it easy to manage and visualize large data sets with general public. Novel visualization techniques and dynamic user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The floodplain simulation system is a web-based 3D interactive flood simulation environment to create real world flooding scenarios. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create and modify predefined scenarios, control environmental parameters, and evaluate flood mitigation techniques. The web-based simulation system provides an environment to children and adults learn about the flooding, flood damage, and effects of development and human activity in the floodplain. The system provides various scenarios customized to fit the age and education level of the users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various flooding and land use scenarios.

Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers.

PubMed

Wang, Mian-Ying; Peng, Lin; Jensen, Claude J; Deng, Shixin; West, Brett J

2013-03-01

Food plants provide important phytochemicals which help improve or maintain health through various biological activities, including antioxidant effects. Cigarette smoke-induced oxidative stress leads to the formation of lipid hydroperoxides (LOOHs) and their decomposition product malondialdehyde (MDA), both of which cause oxidative damage to DNA. Two hundred forty-five heavy cigarette smokers completed a randomized, double-blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on LOOH- and MDA-DNA adducts in peripheral blood lymphocytes (PBLs). Volunteers drank noni juice or a fruit juice placebo every day for 1 month. DNA adducts were measured by (32)P postlabeling analysis. Drinking 29.5-118 mL of noni juice significantly reduced adducts by 44.6-57.4%. The placebo, which was devoid of iridoid glycosides, did not significantly influence LOOH- and MDA-DNA adduct levels in current smokers. Noni juice was able to mitigate oxidative damage of DNA in current heavy smokers, an activity associated with the presence of iridoids.

Precision resection of intestine using ultrashort laser pulses

NASA Astrophysics Data System (ADS)

Beck, Rainer J.; Gora, Wojciech S.; Jayne, David; Hand, Duncan P.; Shephard, Jonathan D.

2016-03-01

Endoscopic resection of early colorectal neoplasms typically employs electrocautery tools, which lack precision and run the risk of full thickness thermal injury to the bowel wall with subsequent perforation. We present a means of endoluminal colonic ablation using picosecond laser pulses as a potential alternative to mitigate these limitations. High intensity ultrashort laser pulses enable nonlinear absorption processes, plasma generation, and as a consequence a predominantly non-thermal ablation regimen. Robust process parameters for the laser resection are demonstrated using fresh ex vivo pig intestine samples. Square cavities with comparable thickness to early colorectal neoplasms are removed for a wavelength of 1030 nm and 515 nm using a picosecond laser system. The corresponding histology sections exhibit in both cases only minimal collateral damage to the surrounding tissue. The ablation depth can be controlled precisely by means of the pulse energy. Overall, the application of ultrafast lasers for the resection of intestine enables significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional electrocautery.

Noni juice reduces lipid peroxidation–derived DNA adducts in heavy smokers

PubMed Central

Wang, Mian-Ying; Peng, Lin; Jensen, Claude J; Deng, Shixin; West, Brett J

2013-01-01

Food plants provide important phytochemicals which help improve or maintain health through various biological activities, including antioxidant effects. Cigarette smoke–induced oxidative stress leads to the formation of lipid hydroperoxides (LOOHs) and their decomposition product malondialdehyde (MDA), both of which cause oxidative damage to DNA. Two hundred forty-five heavy cigarette smokers completed a randomized, double-blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on LOOH- and MDA-DNA adducts in peripheral blood lymphocytes (PBLs). Volunteers drank noni juice or a fruit juice placebo every day for 1 month. DNA adducts were measured by 32P postlabeling analysis. Drinking 29.5–118 mL of noni juice significantly reduced adducts by 44.6–57.4%. The placebo, which was devoid of iridoid glycosides, did not significantly influence LOOH- and MDA-DNA adduct levels in current smokers. Noni juice was able to mitigate oxidative damage of DNA in current heavy smokers, an activity associated with the presence of iridoids. PMID:24804023

Assessing Hurricane Katrina Vegetation Damage at Stennis Space Center using IKONOS Image Classification Techniques

NASA Technical Reports Server (NTRS)

Spruce, Joseph P.; Ross, Kenton W.; Graham, William D.

2006-01-01

Hurricane Katrina inflicted widespread damage to vegetation in southwestern coastal Mississippi upon landfall on August 29, 2005. Storm damage to surface vegetation types at the NASA John C. Stennis Space Center (SSC) was mapped and quantified using IKONOS data originally acquired on September 2, 2005, and later obtained via a Department of Defense ClearView contract. NASA SSC management required an assessment of the hurricane s impact to the 125,000-acre buffer zone used to mitigate rocket engine testing noise and vibration impacts and to manage forestry and fire risk. This study employed ERDAS IMAGINE software to apply traditional classification techniques to the IKONOS data. Spectral signatures were collected from multiple ISODATA classifications of subset areas across the entire region and then appended to a master file representative of major targeted cover type conditions. The master file was subsequently used with the IKONOS data and with a maximum likelihood algorithm to produce a supervised classification later refined using GIS-based editing. The final results enabled mapped, quantitative areal estimates of hurricane-induced damage according to general surface cover type. The IKONOS classification accuracy was assessed using higher resolution aerial imagery and field survey data. In-situ data and GIS analysis indicate that the results compare well to FEMA maps of flooding extent. The IKONOS classification also mapped open areas with woody storm debris. The detection of such storm damage categories is potentially useful for government officials responsible for hurricane disaster mitigation.

Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration.

PubMed

Pietrofesa, Ralph A; Solomides, Charalambos C; Christofidou-Solomidou, Melpo

Spaceflight missions may require crewmembers to conduct extravehicular activities (EVA). Pre-breathe protocols in preparation for an EVA entail 100% hyperoxia exposure that may last for a few hours and be repeated 2-3 times weekly. Each EVA is associated with additional challenges such as low levels of total body cosmic/galactic radiation exposure that may present a threat to crewmember health. We have developed a mouse model of total body radiation and hyperoxia exposure and identified acute damage of lung tissues. In the current study we evaluated the usefulness of dietary flaxseed (FS) as a countermeasure agent for such double-hit exposures. We evaluated lung tissue changes 2 weeks post-initiation of exposure challenges. Mouse cohorts (n=5/group) were pre-fed diets containing either 0% FS or 10% FS for 3 weeks and exposed to: a) normoxia (Untreated); b) >95% O 2 (O 2 ); c) 0.25Gy single fraction gamma radiation (IR); or d) a combination of O 2 and IR (O 2 +IR) 3 times per week for 2 consecutive weeks, where 8-hour hyperoxia treatments were spanned by normoxic intervals. At 2 weeks post challenge, while control-diet fed mice developed significant lung injury and inflammation across all challenges, FS protected lung tissues by decreasing bronchoalveolar lavage fluid (BALF) neutrophils (p<0.003) and protein levels, oxidative tissue damage, as determined by levels of malondialdehyde (MDA) (p<0.008) and nitrosative stress as determined by nitrite levels. Lung hydroxyproline levels, a measure of lung fibrosis, were significantly elevated in mice fed 0% FS (p<0.01) and exposed to hyperoxia/radiation or the combination treatment, but not in FS-fed mice. FS also decreased levels of a pro-inflammatory, pro-fibrogenic cytokine (TGF-β1) gene expression levels in lung. Flaxseed mitigated adverse effects in lung of repeat exposures to radiation/hyperoxia. This data will provide useful information in the design of countermeasures to early tissue oxidative damage associated with space exploration.

Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration

PubMed Central

Pietrofesa, Ralph A.; Solomides, Charalambos C.; Christofidou-Solomidou, Melpo

2015-01-01

Background Spaceflight missions may require crewmembers to conduct extravehicular activities (EVA). Pre-breathe protocols in preparation for an EVA entail 100% hyperoxia exposure that may last for a few hours and be repeated 2-3 times weekly. Each EVA is associated with additional challenges such as low levels of total body cosmic/galactic radiation exposure that may present a threat to crewmember health. We have developed a mouse model of total body radiation and hyperoxia exposure and identified acute damage of lung tissues. In the current study we evaluated the usefulness of dietary flaxseed (FS) as a countermeasure agent for such double-hit exposures. Methods We evaluated lung tissue changes 2 weeks post-initiation of exposure challenges. Mouse cohorts (n=5/group) were pre-fed diets containing either 0% FS or 10% FS for 3 weeks and exposed to: a) normoxia (Untreated); b) >95% O2 (O2); c) 0.25Gy single fraction gamma radiation (IR); or d) a combination of O2 and IR (O2+IR) 3 times per week for 2 consecutive weeks, where 8-hour hyperoxia treatments were spanned by normoxic intervals. Results At 2 weeks post challenge, while control-diet fed mice developed significant lung injury and inflammation across all challenges, FS protected lung tissues by decreasing bronchoalveolar lavage fluid (BALF) neutrophils (p<0.003) and protein levels, oxidative tissue damage, as determined by levels of malondialdehyde (MDA) (p<0.008) and nitrosative stress as determined by nitrite levels. Lung hydroxyproline levels, a measure of lung fibrosis, were significantly elevated in mice fed 0% FS (p<0.01) and exposed to hyperoxia/radiation or the combination treatment, but not in FS-fed mice. FS also decreased levels of a pro-inflammatory, pro-fibrogenic cytokine (TGF-β1) gene expression levels in lung. Conclusion Flaxseed mitigated adverse effects in lung of repeat exposures to radiation/hyperoxia. This data will provide useful information in the design of countermeasures to early tissue oxidative damage associated with space exploration. PMID:25705570

Southern pine beetle in loblolly pine: simulating within stand interactions using the process model SPBLOBTHIN

Treesearch

Brian Strom; J. R. Meeker; J. Bishir; James Roberds; X. Wan

2016-01-01

Pine stand density is a key determinant of damage resulting from attacks by the southern pine beetle (SPB, Dendroctonus frontalis Zimm.). High-density stands of maturing loblolly pine (Pinus taeda L.) are at high risk for losses to SPB, and reducing stand density is the primary tool available to forest managers for preventing and mitigating damage. Field studies are...

Earthquake and Tsunami Disaster Mitigation in The Marmara Region and Disaster Education in Turkey Part2 Yoshiyuki KANEDA Nagoya University Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Haluk OZENER Boğaziçi University, Earthquake Researches Institute (KOERI) and Members of SATREPS Japan-Turkey project

NASA Astrophysics Data System (ADS)

Kaneda, Y.; Ozener, H.

2015-12-01

The 1999 Izumit Earthquake as the destructive earthquake occurred near the Marmara Sea. The Marmara Sea should be focused on because of a seismic gap in the North Anatolian fault. Istanbul is located around the Marmara Sea, so, if next earthquake will occur near Istanbul, fatal damages will be generated. The Japan and Turkey can share our own experiences during past damaging earthquakes and we can prepare for future large earthquakes in cooperation with each other. In earthquakes in Tokyo area and Istanbul area as the destructive earthquakes near high population cities, there are common disaster researches and measures. For disaster mitigation, we are progressing multidisciplinary researches. Our goals of this SATREPS project are as follows, To develop disaster mitigation policy and strategies based on multidisciplinary research activities. To provide decision makers with newly found knowledge for its implementation to the current regulations. To organize disaster education programs in order to increase disaster awareness in Turkey. To contribute the evaluation of active fault studies in Japan. This project is composed of four research groups. The first group is Marmara Earthquake Source region observationally research group. This group has 4 sub-themes such as Seismicity, Geodesy, Electromagnetics and Trench analyses. The second group focuses on scenario researches of earthquake occurrence along the North Anatolia fault and precise tsunami simulation in the Marmara region. Aims of the third group are improvements and constructions of seismic characterizations and damage predictions based on observation researches and precise simulations. The fourth group is promoting disaster educations using research result visuals. In this SATREPS project, we will integrate these research results for disaster mitigation in Marmara region and .disaster education in Turkey. We will have a presentation of the updated results of this SATREPS project.

Damage sources for the NIF Grating Debris Shield (GDS) and methods for their mitigation

NASA Astrophysics Data System (ADS)

Carr, C. W.; Bude, J.; Miller, P. E.; Parham, T.; Whitman, P.; Monticelli, M.; Raman, R.; Cross, D.; Welday, B.; Ravizza, F.; Suratwala, T.; Davis, J.; Fischer, M.; Hawley, R.; Lee, H.; Matthews, M.; Norton, M.; Nostrand, M.; Vanblarcom, D.; Sommer, S.

2017-11-01

The primary sources of damage on the National Ignition Facility (NIF) Grating Debris Shield (GDS) are attributed to two independent types of laser-induced particulates. The first comes from the eruptions of bulk damage in a disposable debris shield downstream of the GDS. The second particle source comes from stray light focusing on absorbing glass armor at higher than expected fluences. We show that the composition of the particles is secondary to the energetics of their delivery, such that particles from either source are essentially benign if they arrive at the GDS with low temperatures and velocities.

Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation.

PubMed

Farhood, Bagher; Goradel, Nasser Hashemi; Mortezaee, Keywan; Khanlarkhani, Neda; Salehi, Ensieh; Nashtaei, Maryam Shabani; Shabeeb, Dheyauldeen; Musa, Ahmed Eleojo; Fallah, Hengameh; Najafi, Masoud

2018-06-17

Nowadays, using ionizing radiation (IR) is necessary for clinical, agricultural, nuclear energy or industrial applications. Accidental exposure to IR after a radiation terror or disaster poses a threat to human. In contrast to the old dogma of radiation toxicity, several experiments during the last two recent decades have revealed that intercellular signaling and communications play a key role in this procedure. Elevated level of cytokines and other intercellular signals increase oxidative damage and inflammatory responses via reduction/oxidation interactions (redox system). Intercellular signals induce production of free radicals and inflammatory mediators by some intermediate enzymes such as cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), NADPH oxidase, and also via triggering mitochondrial ROS. Furthermore, these signals facilitate cell to cell contact and increasing cell toxicity via cohort effect. Nitric oxide is a free radical with ability to act as an intercellular signal that induce DNA damage and changes in some signaling pathways in irradiated as well as non-irradiated adjacent cells. Targeting of these mediators by some anti-inflammatory agents or via antioxidants such as mitochondrial ROS scavengers opens a window to mitigate radiation toxicity after an accidental exposure. Experiments which have been done so far suggests that some cytokines such as IL-1β, TNF-α, TGF-β, IL-4 and IL-13 are some interesting targets that depend on irradiated organs and may help mitigate radiation toxicity. Moreover, animal experiments in recent years indicated that targeting of toll like receptors (TLRs) may be more useful for radioprotection and mitigation. In this review, we aimed to describe the role of intercellular interactions in oxidative injury, inflammation, cell death and killing effects of IR. Moreover, we described evidence on potential mitigation of radiation injury via targeting of these mediators.

Novel Regenerative Peptide TP508 Mitigates Radiation-Induced Gastrointestinal Damage By Activating Stem Cells and Preserving Crypt Integrity

PubMed Central

Kantara, Carla; Moya, Stephanie M.; Houchen, Courtney W.; Umar, Shahid; Ullrich, Robert L.; Singh, Pomila; Carney, Darrell H.

2015-01-01

In recent years, increasing threats of radiation exposure and nuclear disasters have become a significant concern for the United States and countries worldwide. Exposure to high doses of radiation triggers a number of potentially lethal effects. Among the most severe is the gastrointestinal (GI) toxicity syndrome caused by the destruction of the intestinal barrier, resulting in bacterial translocation, systemic bacteremia, sepsis and death. The lack of effective radioprotective agents capable of mitigating radiation-induced damage has prompted a search for novel countermeasures that can mitigate the effects of radiation post-exposure, accelerate tissue repair in radiation-exposed individuals, and prevent mortality. We report that a single injection of regenerative peptide TP508 (rusalatide acetate, Chrysalin®) 24h after lethal radiation exposure (9Gy, LD100/15) appears to significantly increase survival and delay mortality by mitigating radiation-induced intestinal and colonic toxicity. TP508 treatment post-exposure prevents the disintegration of gastrointestinal crypts, stimulates the expression of adherens junction protein E-cadherin, activates crypt cell proliferation, and decreases apoptosis. TP508 post-exposure treatment also up-regulates the expression of DCLK1 and LGR5 markers of stem cells that have been shown to be responsible for maintaining and regenerating intestinal crypts. Thus, TP508 appears to mitigate the effects of GI toxicity by activating radioresistant stem cells and increasing the stemness potential of crypts to maintain and restore intestinal integrity. These results suggest that TP508 may be an effective emergency nuclear countermeasure that could be delivered within 24h post-exposure to increase survival and delay mortality, giving victims time to reach clinical sites for advanced medical treatment. PMID:26280221

Acoustic characteristics of Dynastid beetle stridulations

USDA-ARS?s Scientific Manuscript database

Oryctes rhinoceros (L.) (Coleoptera: Scarabaeidae: Dynastinae) causes economically important damage to ornamental and commercial coconut palm trees in the western Pacific region that could be mitigated significantly by early detection and treatment. Adults are difficult to detect visually, however...

Low-cost rural surface alternatives : demonstration project.

DOT National Transportation Integrated Search

2015-06-01

The goals of this project were to implement several stabilization methods for preventing or mitigating freeze-thaw damage to : granular surfaced roads and identify the most effective and economical methods for the soil and climate conditions of Iowa....

Radioactive source calibration test of the CMS Hadron Endcap Calorimeter test wedge with Phase I upgrade electronics

NASA Astrophysics Data System (ADS)

Chatrchyan, S.; Sirunyan, A. M.; Tumasyan, A.; Litomin, A.; Mossolov, V.; Shumeiko, N.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Spilbeeck, A.; Alves, G. A.; Aldá Júnior, W. L.; Hensel, C.; Carvalho, W.; Chinellato, J.; De Oliveira Martins, C.; Matos Figueiredo, D.; Mora Herrera, C.; Nogima, H.; Prado Da Silva, W. L.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Finger, M.; Finger, M., Jr.; Kveton, A.; Tomsa, J.; Adamov, G.; Tsamalaidze, Z.; Behrens, U.; Borras, K.; Campbell, A.; Costanza, F.; Gunnellini, P.; Lobanov, A.; Melzer-Pellmann, I.-A.; Muhl, C.; Roland, B.; Sahin, M.; Saxena, P.; Hegde, V.; Kothekar, K.; Pandey, S.; Sharma, S.; Beri, S. B.; Bhawandeep, B.; Chawla, R.; Kalsi, A.; Kaur, A.; Kaur, M.; Walia, G.; Bhattacharya, S.; Ghosh, S.; Nandan, S.; Purohit, A.; Sharan, M.; Banerjee, S.; Bhattacharya, S.; Chatterjee, S.; Das, P.; Guchait, M.; Jain, S.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Patil, M.; Sarkar, T.; Juodagalvis, A.; Afanasiev, S.; Bunin, P.; Ershov, Y.; Golutvin, I.; Malakhov, A.; Moisenz, P.; Smirnov, V.; Zarubin, A.; Chadeeva, M.; Chistov, R.; Danilov, M.; Popova, E.; Rusinov, V.; Andreev, Yu.; Dermenev, A.; Karneyeu, A.; Krasnikov, N.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Toms, M.; Zhokin, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Kaminskiy, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Terkulov, A.; Bitioukov, S.; Elumakhov, D.; Kalinin, A.; Krychkine, V.; Mandrik, P.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Volkov, A.; Sekmen, S.; Rumerio, P.; Adiguzel, A.; Bakirci, N.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. S.; Dölek, F.; Dozen, C.; Dumanoglu, I.; Eskut, E.; Girgis, S.; Gokbulut, G.; Guler, Y.; Hos, I.; Kangal, E. E.; Kara, O.; Kayis Topaksu, A.; Işik, C.; Kiminsu, U.; Oglakci, M.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Polatoz, A.; Sunar Cerci, D.; Tali, B.; Topakli, H.; Turkcapar, S.; Zorbakir, I. S.; Zorbilmez, C.; Bilin, B.; Isildak, B.; Karapinar, G.; Murat Guler, A.; Ocalan, K.; Yalvac, M.; Zeyrek, M.; Atakisi, I. O.; Gülmez, E.; Kaya, M.; Kaya, O.; Koseyan, O. K.; Ozcelik, O.; Ozkorucuklu, S.; Tekten, S.; Yetkin, E. A.; Yetkin, T.; Cankocak, K.; Sen, S.; Boyarintsev, A.; Grynyov, B.; Levchuk, L.; Popov, V.; Sorokin, P.; Flacher, H.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Buccilli, A.; Cooper, S. I.; Henderson, C.; West, C.; Arcaro, D.; Gastler, D.; Hazen, E.; Rohlf, J.; Sulak, L.; Wu, S.; Zou, D.; Hakala, J.; Heintz, U.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Mao, Z.; Yu, D. R.; Gary, J. W.; Ghiasi Shirazi, S. M.; Lacroix, F.; Long, O. R.; Wei, H.; Bhandari, R.; Heller, R.; Stuart, D.; Yoo, J. H.; Chen, Y.; Duarte, J.; Lawhorn, J. M.; Nguyen, T.; Spiropulu, M.; Winn, D.; Abdullin, S.; Apresyan, A.; Apyan, A.; Banerjee, S.; Chlebana, F.; Freeman, J.; Green, D.; Hare, D.; Hirschauer, J.; Joshi, U.; Lincoln, D.; Los, S.; Pedro, K.; Spalding, W. J.; Strobbe, N.; Tkaczyk, S.; Whitbeck, A.; Linn, S.; Markowitz, P.; Martinez, G.; Bertoldi, M.; Hagopian, S.; Hagopian, V.; Kolberg, T.; Baarmand, M. M.; Noonan, D.; Roy, T.; Yumiceva, F.; Bilki, B.; Clarida, W.; Debbins, P.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Miller, M.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Schmidt, I.; Snyder, C.; Southwick, D.; Tiras, E.; Yi, K.; Al-bataineh, A.; Bowen, J.; Castle, J.; McBrayer, W.; Murray, M.; Wang, Q.; Kaadze, K.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Baden, A.; Belloni, A.; Calderon, J. D.; Eno, S. C.; Feng, Y. B.; Ferraioli, C.; Grassi, T.; Hadley, N. J.; Jeng, G.-Y.; Kellogg, R. G.; Kunkle, J.; Mignerey, A.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Yang, Z. S.; Yao, Y.; Brandt, S.; D'Alfonso, M.; Hu, M.; Klute, M.; Niu, X.; Chatterjee, R. M.; Evans, A.; Frahm, E.; Kubota, Y.; Lesko, Z.; Mans, J.; Ruckstuhl, N.; Heering, A.; Karmgard, D. J.; Musienko, Y.; Ruchti, R.; Wayne, M.; Benaglia, A. D.; Medvedeva, T.; Mei, K.; Tully, C.; Bodek, A.; de Barbaro, P.; Galanti, M.; Garcia-Bellido, A.; Khukhunaishvili, A.; Lo, K. H.; Vishnevskiy, D.; Zielinski, M.; Agapitos, A.; Amouzegar, M.; Chou, J. P.; Hughes, E.; Saka, H.; Sheffield, D.; Akchurin, N.; Damgov, J.; De Guio, F.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Mengke, T.; Muthumuni, S.; Undleeb, S.; Volobouev, I.; Wang, Z.; Goadhouse, S.; Hirosky, R.; Wang, Y.

2017-12-01

The Phase I upgrade of the CMS Hadron Endcap Calorimeters consists of new photodetectors (Silicon Photomultipliers in place of Hybrid Photo-Diodes) and front-end electronics. The upgrade will eliminate the noise and the calibration drift of the Hybrid Photo-Diodes and enable the mitigation of the radiation damage of the scintillators and the wavelength shifting fibers with a larger spectral acceptance of the Silicon Photomultipliers. The upgrade also includes increased longitudinal segmentation of the calorimeter readout, which allows pile-up mitigation and recalibration due to depth-dependent radiation damage. As a realistic operational test, the responses of the Hadron Endcap Calorimeter wedges were calibrated with a 60Co radioactive source with upgrade electronics. The test successfully established the procedure for future source calibrations of the Hadron Endcap Calorimeters. Here we describe the instrumentation details and the operational experiences related to the sourcing test.

Translating the Potential of Stem Cells for Diabetes Mellitus: Challenges and Opportunities.

PubMed

Masoud, Muhammad Shareef; Qasim, Muhammad; Ali, Muhammad Umar

2017-01-01

Diabetes mellitus, the widely prevalent disease of pancreas, is a metabolic disorder caused by autoimmune destruction of β cells or insulin insufficiency or insulin resistance. Replacement of damaged β cells by cell therapy can mitigate the condition and re-establish normal metabolic control. This has opened up new horizons for research, such as stem cells, cellular reprogramming and β cell regeneration. The goal of the study was to summarize the available literature on the use of stem cells for the regeneration of pancreatic β cells and treatment of diabetes mellitus. Stem cells are exceptional having the potential to self renew and differentiate in many lineages. Stem cells hold tremendous potential to regenerate β cells and treat diabetes mellitus but many milestones on the way are yet to be achieved. But researchers do believe that stem cells and regenerative medicines will be widely used in clinical practices and possibly new effective methodology would be designed for even cure, mitigate and reduce the social burden of diabetes mellitus. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury.

PubMed

Shi, Hong; Wang, Hai-Lian; Pu, Hong-Jian; Shi, Ye-Jie; Zhang, Jia; Zhang, Wen-Ting; Wang, Guo-Hua; Hu, Xiao-Ming; Leak, Rehana K; Chen, Jun; Gao, Yan-Qin

2015-04-01

Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive impairments due to the lack of defined therapies to reduce TBI-induced long-term brain damage. Ethyl pyruvate (EP) has shown neuroprotection in several models of acute brain injury. The present study therefore investigated the potential beneficial effect of EP on long-term outcomes after TBI and the underlying mechanisms. Male adult rats were subjected to unilateral controlled cortical impact injury. EP was injected intraperitoneally 15 min after TBI and again at 12, 24, 36, 48, and 60 h after TBI. Neurological deficits, blood-brain barrier (BBB) integrity, and neuroinflammation were assessed. Ethyl pyruvate improved sensorimotor and cognitive functions and ameliorated brain tissue damage up to 28 day post-TBI. BBB breach and brain edema were attenuated by EP at 48 h after TBI. EP suppressed matrix metalloproteinase (MMP)-9 production from peripheral neutrophils and reduced the number of MMP-9-overproducing neutrophils in the spleen, and therefore mitigated MMP-9-mediated BBB breakdown. Moreover, EP exerted potent antiinflammatory effects in cultured microglia and inhibited the elevation of inflammatory mediators in the brain after TBI. Ethyl pyruvate confers long-term neuroprotection against TBI, possibly through breaking the vicious cycle among MMP-9-mediated BBB disruption, neuroinflammation, and long-lasting brain damage. © 2014 John Wiley & Sons Ltd.

Ethanolic extract of Moringa oleifera Lam. leaves protect the pre-pubertal spermatogonial cells from cyclophosphamide-induced damage.

PubMed

Nayak, Guruprasad; Honguntikar, Sachin D; Kalthur, Sneha Guruprasad; D'Souza, Antony Sylvan; Mutalik, Srinivas; Setty, Manjunath M; Kalyankumar, Raksha; Krishnamurthy, Hanumanthappa; Kalthur, Guruprasad; Adiga, Satish Kumar

2016-04-22

Moringa oleifera Lam. is widely cultivated in Asian and African countries for its medicinal and dietary significance. The leaves are highly nutritious and are known to possess various biological activities. Pre-pubertal Swiss albino male mice were injected with single dose of cyclophosphamide (CP, 200mg/kg body weight) or ethanolic extract of Moringa oleifera leaves (MOE, 100mg/kg body weight) intraperitoneally. In combination group, MOE was administered 24h prior to CP injection. CP induced a significant decrease in testicular weight (p<0.01) and depletion of germ cells (p<0.001) and higher level of DNA damage (p<0.001) compared to control. The expression of P53, Bax, Cytochrome C (Cyt C) was increased while there was a decrease in the expression of Bcl2, c-Kit and Oct4. Administration of MOE 24h prior to CP treatment ameliorated the depletion (p<0.001), DNA damage (p<0.001) and apoptosis (p<0.01) of germ cells induced by CP. The mitigating effect of MOE appears to be mediated by up-regulating the expression of c-Kit and Oct4 transcripts in P53-independent manner. MOE protects the spermatogonial cells from CP-induced damage by modulating the apoptotic response elicited by CP and therefore can be considered as an efficient method of male fertility preservation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, Greg; Marotz, Brian L.; Dunnigan, James

''Mitigation for the Construction and Operation of Libby Dam'' is part of the Northwest Power Planning Council's resident fish and wildlife program. The program was mandated by the Northwest Planning Act of 1980, and is responsible for mitigating for damages to fish and wildlife caused by hydroelectric development in the Columbia River Basin. The objective of Phase I of the project (1983 through 1987) was to maintain or enhance the Libby Reservoir fishery by quantifying seasonal water levels and developing ecologically sound operational guidelines. The objective of Phase II of the project (1988 through 1996) was to determine the biologicalmore » effects of reservoir operations combined with biotic changes associated with an aging reservoir. The objectives of Phase III of the project (1996 through present) are to implement habitat enhancement measures to mitigate for dam effects, to provide data for implementation of operational strategies that benefit resident fish, monitor reservoir and river conditions, and monitor mitigation projects for effectiveness.« less

An Optimal Mitigation Strategy Against the Asteroid Impact Threat with Short Warning Time

NASA Technical Reports Server (NTRS)

Wie, Bong; Barbee, Brent W.

2015-01-01

This paper presents the results of a NASA Innovative Advanced Concept (NIAC) Phase 2 study entitled "An Innovative Solution to NASA's Near-Earth Object (NEO) Impact Threat Mitigation Grand Challenge and Flight Validation Mission Architecture Development." This NIAC Phase 2 study was conducted at the Asteroid Deflection Research Center (ADRC) of Iowa State University in 2012-2014. The study objective was to develop an innovative yet practically implementable mitigation strategy for the most probable impact threat of an asteroid or comet with short warning time (less than 5 years). The mitigation strategy described in this paper is intended to optimally reduce the severity and catastrophic damage of the NEO impact event, especially when we don't have sufficient warning times for non-disruptive deflection of a hazardous NEO. This paper provides an executive summary of the NIAC Phase 2 study results.

Potential for thermal damage to the blood–brain barrier during craniotomy: implications for intracortical recording microelectrodes

NASA Astrophysics Data System (ADS)

Shoffstall, Andrew J.; Paiz, Jen E.; Miller, David M.; Rial, Griffin M.; Willis, Mitchell T.; Menendez, Dhariyat M.; Hostler, Stephen R.; Capadona, Jeffrey R.

2018-06-01

Objective. Our objective was to determine how readily disruption of the blood–brain barrier (BBB) occurred as a result of bone drilling during a craniotomy to implant microelectrodes in rat cortex. While the phenomenon of heat production during bone drilling is well known, practices to evade damage to the underlying brain tissue are inconsistently practiced and reported in the literature. Approach. We conducted a review of the intracortical microelectrode literature to summarize typical approaches to mitigate drill heating during rodent craniotomies. Post mortem skull-surface and transient brain-surface temperatures were experimentally recorded using an infrared camera and thermocouple, respectively. A number of drilling conditions were tested, including varying drill speed and continuous versus intermittent contact. In vivo BBB permeability was assayed 1 h after the craniotomy procedure using Evans blue dye. Main results. Of the reviewed papers that mentioned methods to mitigate thermal damage during craniotomy, saline irrigation was the most frequently cited (in six of seven papers). In post mortem tissues, we observed increases in skull-surface temperature ranging from  +3 °C to  +21 °C, dependent on drill speed. In vivo, pulsed-drilling (2 s-on/2 s-off) and slow-drilling speeds (1000 r.p.m.) were the most effective methods we studied to mitigate heating effects from drilling, while inconclusive results were obtained with saline irrigation. Significance. Neuroinflammation, initiated by damage to the BBB and perpetuated by the foreign body response, is thought to play a key role in premature failure of intracortical recording microelectrodes. This study demonstrates the extreme sensitivity of the BBB to overheating caused by bone drilling. To avoid damage to the BBB, the authors recommend that craniotomies be drilled with slow speeds and/or with intermittent drilling with complete removal of the drill from the skull during ‘off’ periods. While saline alone was ineffective at preventing overheating, its use is still recommended to remove bone dust from the surgical site and to augment other cooling methods.

Economic valuation of flood mitigation services: A case study from the Otter Creek, VT.

NASA Astrophysics Data System (ADS)

Galford, G. L.; Ricketts, T.; Bryan, K. L.; ONeil-Dunne, J.; Polasky, S.

2014-12-01

The ecosystem services provided by wetlands are widely recognized but difficult to quantify. In particular, estimating the effect of landcover and land use on downstream flood outcomes remains challenging, but is increasingly important in light of climate change predictions of increased precipitation in many areas. Economic valuation can help incorporate ecosystem services into decisions and enable communities to plan for climate and flood resiliency. Here we estimate the economic value of Otter Creek wetlands for Middlebury, VT in mitigating the flood that followed Tropical Storm Irene, as well as for ten historic floods. Observationally, hydrographs above and below the wetlands in the case of each storm indicated the wetlands functioned as a temporary reservoir, slowing the delivery of water to Middlebury. We compare observed floods, based on Middlebury's hydrograph, with simulated floods for scenarios without wetlands. To simulate these "without wetlands" scenarios, we assume the same volume of water was delivered to Middlebury, but in a shorter time pulse similar to a hydrograph upstream of the wetlands. For scenarios with and without wetlands, we map the spatial extent of flooding using LiDAR digital elevation data. We then estimate flood depth at each affected building, and calculate monetary losses as a function of the flood depth and house value using established depth damage relationships. For example, we expect damages equal to 20% of the houses value for a flood depth of two feet in a two-story home with a basement. We define the value of flood mitigation services as the difference in damages between the with and without wetlands scenario, and find that the Otter Creek wetlands reduced flood damage in Middlebury by 88% following Hurricane Irene. Using the 10 additional historic floods, we estimate an ongoing mean value of $400,000 in avoided damages per year. Economic impacts of this magnitude stress the importance of wetland conservation and warrant the consideration of ecosystem services in land use decisions. Our study indicates that here and elsewhere, green infrastructure may have to potential to increase the resilience of communities to projected changes in climate.

Thermal control on the lunar surface

NASA Technical Reports Server (NTRS)

Walker, Sherry T.; Alexander, Reginald A.; Tucker, Stephen P.

1995-01-01

For a mission to the Moon which lasts more than a few days, thermal control is a challenging problem because of the Moon's wide temperature swings and long day and night periods. During the lunar day it is difficult to reject heat temperatures low enough to be comfortable for either humans or electronic components, while excessive heat loss can damage unprotected equipment at night. Fluid systems can readily be designed to operate at either the hot or cold temperature extreme but it is more difficult to accomodate both extermes within the same system. Special consideration should be given to sensitive systems, such as optics and humans, and systems that generate large amounts of waste heat, such as lunar bases or manufacturing facilities. Passive thermal control systems such as covers, shades and optical coatings can be used to mitigate the temperature swings experienced by components. For more precise thermal control active systems such as heaters or heat pumps are required although they require more power than passive systems.

Policy learning for flood mitigation: a longitudinal assessment of the community rating system in Florida.

PubMed

Brody, Samuel D; Zahran, Sammy; Highfield, Wesley E; Bernhardt, Sarah P; Vedlitz, Arnold

2009-06-01

Floods continue to inflict the most damage upon human communities among all natural hazards in the United States. Because localized flooding tends to be spatially repetitive over time, local decisionmakers often have an opportunity to learn from previous events and make proactive policy adjustments to reduce the adverse effects of a subsequent storm. Despite the importance of understanding the degree to which local jurisdictions learn from flood risks and under what circumstances, little if any empirical, longitudinal research has been conducted along these lines. This article addresses the research gap by examining the change in local flood mitigation policies in Florida from 1999 to 2005. We track 18 different mitigation activities organized into four series of activities under the Federal Emergency Management Agency's (FEMA) Community Rating System (CRS) for every local jurisdiction in Florida participating in the FEMA program on a yearly time step. We then identify the major factors contributing to policy changes based on CRS scores over the seven-year study period. Using multivariate statistical models to analyze both natural and social science data, we isolate the effects of several variables categorized into the following groups: hydrologic conditions, flood disaster history, socioeconomic and human capital controls. Results indicate that local jurisdictions do in fact learn from histories of flood risk and this process is expedited under specific conditions.

Pre-damage biomass allocation and not invasiveness predicts tolerance to damage in seedlings of woody species in Hawaii.

PubMed

Lurie, Matthew H; Barton, Kasey E; Daehler, Curtis C

2017-12-01

Plant-herbivore interactions have been predicted to play a fundamental role in plant invasions, although support for this assertion from previous research is mixed. While plants may escape from specialist herbivores in their introduced ranges, herbivory from generalists is common. Tolerance traits may allow non-native plants to mitigate the negative consequences of generalist herbivory that they cannot avoid in their introduced range. Here we address whether tolerance to herbivory, quantified as survival and compensatory growth, is associated with plant invasion success in Hawaii and investigate traits that may enhance tolerance in seedlings, the life stage most susceptible to herbivory. In a greenhouse experiment, we measured seedling tolerance to simulated herbivory through mechanical damage (50% leaf removal) of 16 non-native woody plant species differing in invasion status (invasive vs. non-invasive). Seedlings were grown for 2 weeks following damage and analyzed for biomass to determine whether damaged plants could fully compensate for the lost leaf tissue. Over 99% of all seedlings survived defoliation. Although species varied significantly in their levels of compensation, there was no consistent difference between invasive and non-invasive species. Seedlings of 11 species undercompensated and remained substantially smaller than control seedlings 2 weeks after damage; four species were close to compensating, while one species overcompensated. Across species, compensation was positively associated with an increased investment in potential storage reserves, specifically cotyledons and roots, suggesting that these organs provide resources that help seedlings re-grow following damage. Our results add to a growing consensus that pre-damage growth patterns determine tolerance to damage, even in young seedlings which have relatively low biomass. The lack of higher tolerance in highly invasive species may suggest that invaders overcome herbivory barriers to invasion in other ways, such as resistance traits, or that herbivory does not play an important role in the seedling invasion dynamics of these woody species in Hawaii. © 2017 by the Ecological Society of America.

UV-B susceptibility and photoreactivation in embryonic development of the two-spotted spider mite, Tetranychus urticae.

PubMed

Yoshioka, Yoshio; Gotoh, Tetsuo; Suzuki, Takeshi

2018-05-14

Developmental errors are often induced in the embryos of many organisms by environmental stress. Ultraviolet-B radiation (UV-B) is one of the most serious environmental stressors in embryonic development. Here, we investigated susceptibility to UV-B (0.5 kJ m -2 ) in embryos of the two-spotted spider mite, Tetranychus urticae, to examine the potential use of UV-B in control of this important agricultural pest worldwide. Peak susceptibility to UV-B (0% hatchability) was found in T. urticae eggs 36-48 h after oviposition at 25 °C, which coincides with the stages of morphogenesis forming the germ band and initial limb primordia. However, hatchability recovered to ~ 80% when eggs irradiated with UV-B were subsequently exposed to visible radiation (VIS) at 10.2 kJ m -2 , driving photoreactivation (the photoenzymatic repair of DNA damage). The recovery effect decreased to 40-70% hatchability, depending on the embryonic developmental stage, when VIS irradiation was delayed for 4 h after the end of exposure to UV-B. Thus UV-B damage to T. urticae embryos is critical, particularly in the early stages of morphogenesis, and photoreactivation functions to mitigate UV-B damage, even in the susceptible stages, but immediate VIS irradiation is needed after exposure to UV-B. These findings suggest that nighttime irradiation with UV-B can effectively kill T. urticae eggs without subsequent photoreactivation and may be useful in the physical control of this species.

Damage assessment in Braunsbach 2016: data collection and analysis for an improved understanding of damaging processes during flash floods

NASA Astrophysics Data System (ADS)

Laudan, Jonas; Rözer, Viktor; Sieg, Tobias; Vogel, Kristin; Thieken, Annegret H.

2017-12-01

Flash floods are caused by intense rainfall events and represent an insufficiently understood phenomenon in Germany. As a result of higher precipitation intensities, flash floods might occur more frequently in future. In combination with changing land use patterns and urbanisation, damage mitigation, insurance and risk management in flash-flood-prone regions are becoming increasingly important. However, a better understanding of damage caused by flash floods requires ex post collection of relevant but yet sparsely available information for research. At the end of May 2016, very high and concentrated rainfall intensities led to severe flash floods in several southern German municipalities. The small town of Braunsbach stood as a prime example of the devastating potential of such events. Eight to ten days after the flash flood event, damage assessment and data collection were conducted in Braunsbach by investigating all affected buildings and their surroundings. To record and store the data on site, the open-source software bundle KoBoCollect was used as an efficient and easy way to gather information. Since the damage driving factors of flash floods are expected to differ from those of riverine flooding, a post-hoc data analysis was performed, aiming to identify the influence of flood processes and building attributes on damage grades, which reflect the extent of structural damage. Data analyses include the application of random forest, a random general linear model and multinomial logistic regression as well as the construction of a local impact map to reveal influences on the damage grades. Further, a Spearman's Rho correlation matrix was calculated. The results reveal that the damage driving factors of flash floods differ from those of riverine floods to a certain extent. The exposition of a building in flow direction shows an especially strong correlation with the damage grade and has a high predictive power within the constructed damage models. Additionally, the results suggest that building materials as well as various building aspects, such as the existence of a shop window and the surroundings, might have an effect on the resulting damage. To verify and confirm the outcomes as well as to support future mitigation strategies, risk management and planning, more comprehensive and systematic data collection is necessary.

19 CFR 172.11 - Petitions acted on by Fines, Penalties, and Forfeitures Officer.

Code of Federal Regulations, 2013 CFR

2013-04-01

... empowered to mitigate any penalty or cancel any claim for liquidated damages on such terms and conditions as... of authority, the Fines, Penalties, and Forfeitures Officer is always empowered to cancel any case...

19 CFR 172.11 - Petitions acted on by Fines, Penalties, and Forfeitures Officer.

Code of Federal Regulations, 2014 CFR

2014-04-01

... empowered to mitigate any penalty or cancel any claim for liquidated damages on such terms and conditions as... of authority, the Fines, Penalties, and Forfeitures Officer is always empowered to cancel any case...

Modeling Reduced Nitrogen Deposition in Regulatory Context

EPA Science Inventory

Wet and dry deposition of gas phase ammonia (NH3) and particulate ammonium (NH4+) contribute substantially to adverse ecological impacts (e.g., eutrophication) from additional nitrogen loading to terrestrial and aquatic systems. Mitigating ecosystem damage from reduced nitrogen ...

Mitigating the consequences of accidents

DOT National Transportation Integrated Search

2005-08-01

If an accident occurs, effective strategies must be available to minimize the effects in terms of loss of life, injury, and property damage. The Volpe Center's work in this area is reviewed in this report. It ranges from occupant protection strategie...

Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun Yang; Kojima, Chikara; Chignell, Colin

2011-09-15

Inorganic arsenic and UV, both human skin carcinogens, may act together as skin co-carcinogens. We find human skin keratinocytes (HaCaT cells) are malignantly transformed by low-level arsenite (100 nM, 30 weeks; termed As-TM cells) and with transformation concurrently undergo full adaptation to arsenic toxicity involving reduced apoptosis and oxidative stress response to high arsenite concentrations. Oxidative DNA damage (ODD) is a possible mechanism in arsenic carcinogenesis and a hallmark of UV-induced skin cancer. In the current work, inorganic arsenite exposure (100 nM) did not induce ODD during the 30 weeks required for malignant transformation. Although acute UV-treatment (UVA, 25 J/cm{supmore » 2}) increased ODD in passage-matched control cells, once transformed by arsenic to As-TM cells, acute UV actually further increased ODD (> 50%). Despite enhanced ODD, As-TM cells were resistant to UV-induced apoptosis. The response of apoptotic factors and oxidative stress genes was strongly mitigated in As-TM cells after UV exposure including increased Bcl2/Bax ratio and reduced Caspase-3, Nrf2, and Keap1 expression. Several Nrf2-related genes (HO-1, GCLs, SOD) showed diminished responses in As-TM cells after UV exposure consistent with reduced oxidant stress response. UV-exposed As-TM cells showed increased expression of cyclin D1 (proliferation gene) and decreased p16 (tumor suppressor). UV exposure enhanced the malignant phenotype of As-TM cells. Thus, the co-carcinogenicity between UV and arsenic in skin cancer might involve adaptation to chronic arsenic exposure generally mitigating the oxidative stress response, allowing apoptotic by-pass after UV and enhanced cell survival even in the face of increased UV-induced oxidative stress and increased ODD. - Highlights: > Arsenic transformation adapted to UV-induced apoptosis. > Arsenic transformation diminished oxidant response. > Arsenic transformation enhanced UV-induced DNA damage.« less

New Approaches to Radiation Protection

PubMed Central

Rosen, Eliot M.; Day, Regina; Singh, Vijay K.

2015-01-01

Radioprotectors are compounds that protect against radiation injury when given prior to radiation exposure. Mitigators can protect against radiation injury when given after exposure but before symptoms appear. Radioprotectors and mitigators can potentially improve the outcomes of radiotherapy for cancer treatment by allowing higher doses of radiation and/or reduced damage to normal tissues. Such compounds can also potentially counteract the effects of accidental exposure to radiation or deliberate exposure (e.g., nuclear reactor meltdown, dirty bomb, or nuclear bomb explosion); hence they are called radiation countermeasures. Here, we will review the general principles of radiation injury and protection and describe selected examples of radioprotectors/mitigators ranging from small-molecules to proteins to cell-based treatments. We will emphasize agents that are in more advanced stages of development. PMID:25653923

Sublethal Total Body Irradiation Leads to Early Cerebellar Damage and Oxidative Stress

DTIC Science & Technology

2010-01-01

mice: protective effect of alpha - lipoic acid . Behav Brain Res 2007b; 177(1): 7-14. [8] Manda K, Ueno M, Anzai K. Melatonin mitigates oxidative...Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha - lipoic acid . Behav Brain Res 2008b...1977; 171(1): 39-50. [6] Manda K, Ueno M, Moritake T, Anzai K. - Lipoic acid attenuates x-irradiation-induced oxidative stress in mice. Cell Biol

Groundwater potential for water supply during droughts in Korea

NASA Astrophysics Data System (ADS)

Hyun, Y.; Cha, E.; Moon, H. J.

2016-12-01

Droughts have been receiving much attention in Korea because severe droughts occurred in recent years, causing significant social, economic and environmental damages in some regions. Residents in agricultural area, most of all, were most damaged by droughts with lack of available water supplies to meet crop water demands. In order to mitigate drought damages, we present a strategy to keep from agricultural droughts by using groundwater to meet water supply as a potential water resource in agricultural areas. In this study, we analyze drought severity and the groundwater potential to mitigate social and environmental damages caused by droughts in Korea. We evaluate drought severity by analyzing spatial and temporal meteorological and hydrological data such as rainfall, water supply and demand. For drought severity, we use effective drought index along with the standardized precipitation index (SPI) and standardized runoff index(SRI). Water deficit during the drought period is also quantified to consider social and environmental impact of droughts. Then we assess the feasibility of using groundwater as a potential source for groundwater impact mitigation. Results show that the agricultural areas are more vulnerable to droughts and use of groundwater as an emergency water resource is feasible in some regions. For a case study, we select Jeong-Sun area located in Kangwon providence having well-developed Karst aquifers and surrounded by mountains. For Jeong-Sun area, we quantify groundwater potential use, design the method of water supply by using groundwater, and assess its economic benefit. Results show that water supply system with groundwater abstraction can be a good strategy when droughts are severe for an emergency water supply in Jeong-Sun area, and groundwater can also be used not only for a dry season water supply resource, but for everyday water supply system. This case study results can further be applicable to some regions with no sufficient water infrastructure and high groundwater use potential. For concrete conclusions, rigorous study on performance evaluation of water supply using groundwater is further needed.

Landslide risk analysis: a multi-disciplinary methodological approach

NASA Astrophysics Data System (ADS)

Sterlacchini, S.; Frigerio, S.; Giacomelli, P.; Brambilla, M.

2007-11-01

This study describes an analysis carried out within the European community project "ALARM" (Assessment of Landslide Risk and Mitigation in Mountain Areas, 2004) on landslide risk assessment in the municipality of Corvara in Badia, Italy. This mountainous area, located in the central Dolomites (Italian Alps), poses a significant landslide hazard to several man-made and natural objects. Three parameters for determining risk were analysed as an aid to preparedness and mitigation planning: event occurrence probability, elements at risk, and the vulnerability of these elements. Initially, a landslide hazard scenario was defined; this step was followed by the identification of the potential vulnerable elements, by the estimation of the expected physical effects, due to the occurrence of a damaging phenomenon, and by the analysis of social and economic features of the area. Finally, a potential risk scenario was defined, where the relationships between the event, its physical effects, and its economic consequences were investigated. People and public administrators with training and experience in local landsliding and slope processes were involved in each step of the analysis. A "cause-effect" correlation was applied, derived from the "dose-response" equation initially used in the biological sciences and then adapted by economists for the assessment of environmental risks. The relationship was analysed from a physical point of view and the cause (the natural event) was correlated to the physical effects, i.e. the aesthetic, functional, and structural damage. An economic evaluation of direct and indirect damage was carried out considering the assets in the affected area (i.e., tourist flows, goods, transport and the effect on other social and economic activities). This study shows the importance of indirect damage, which is as significant as direct damage. The total amount of direct damage was estimated in 8 913 000 €; on the contrary, indirect damage ranged considerably from 2 840 000 to 9 350 000 €, depending on the selected temporal scenario and the expected closing time of the potentially affected structures. The multi-disciplinary approach discussed in this study may assist local decision makers in determining the nature and magnitude of the expected losses due to a dangerous event, which can be anticipated in a given study area, during a specified time period. Besides, a preventive knowledge of the prospective physical effects and economic consequences may help local decision makers to choose the best prevention and mitigation options and to decide how to allocate resources properly, so that potential benefits are maximised at an acceptable cost.

Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy.

PubMed

Moruno-Manchon, Jose F; Uzor, Ndidi-Ese; Kesler, Shelli R; Wefel, Jeffrey S; Townley, Debra M; Nagaraja, Archana Sidalaghatta; Pradeep, Sunila; Mangala, Lingegowda S; Sood, Anil K; Tsvetkov, Andrey S

2018-01-01

Doxorubicin, a commonly used anti-neoplastic agent, causes severe neurotoxicity. Doxorubicin promotes thinning of the brain cortex and accelerates brain aging, leading to cognitive impairment. Oxidative stress induced by doxorubicin contributes to cellular damage. In addition to mitochondria, peroxisomes also generate reactive oxygen species (ROS) and promote cell senescence. Here, we investigated if doxorubicin affects peroxisomal homeostasis in neurons. We demonstrate that the number of peroxisomes is increased in doxorubicin-treated neurons and in the brains of mice which underwent doxorubicin-based chemotherapy. Pexophagy, the specific autophagy of peroxisomes, is downregulated in neurons, and peroxisomes produce more ROS. 2-hydroxypropyl-β-cyclodextrin (HPβCD), an activator of the transcription factor TFEB, which regulates expression of genes involved in autophagy and lysosome function, mitigates damage of pexophagy and decreases ROS production induced by doxorubicin. We conclude that peroxisome-associated oxidative stress induced by doxorubicin may contribute to neurotoxicity, cognitive dysfunction, and accelerated brain aging in cancer patients and survivors. Peroxisomes might be a valuable new target for mitigating neuronal damage caused by chemotherapy drugs and for slowing down brain aging in general. Copyright © 2017 Elsevier Inc. All rights reserved.

Economic resilience lessons from the ShakeOut earthquake scenario

USGS Publications Warehouse

Wein, A.; Rose, A.

2011-01-01

Following a damaging earthquake, “business interruption” (BI)—reduced production of goods and services—begins and continues long after the ground shaking stops. Economic resilience reduces BI losses by making the best use of the resources available at a given point in time (static resilience) or by speeding recovery through repair and reconstruction (dynamic resilience), in contrast to mitigation that prevents damage in the first place. Economic resilience is an important concept to incorporate into economic loss modeling and in recovery and contingency planning. Economic resilience framework includes the applicability of resilience strategies to production inputs and output, demand- and supply-side effects, inherent and adaptive abilities, and levels of the economy. We use our resilience framework to organize and share strategies that enhance economic resilience, identify overlooked resilience strategies, and present evidence and structure of resilience strategies for economic loss modelers. Numerous resilience strategies are compiled from stakeholder discussions about the ShakeOut Scenario (Jones et. al. 2008). Modeled results of ShakeOut BI sector losses reveal variable effectiveness of resilience strategies for lengthy disruptions caused by fire-damaged buildings and water service outages. Resilience is a complement to mitigation and may, in fact, have cost and all-hazards advantages.

Health aspects of the Tsunami disaster in Asia.

PubMed

Kapila, Mukesh; McGarry, Nichole; Emerson, Elizabeth; Fink, Sheri; Doran, Rodger; Rejto, Khadija; Profili, Maria Cristina

2005-01-01

This is a summary of the proceedings of the Conference on the Health Aspects of the Tsunami Disaster in Asia that was convened by the World Health Organization in Phuket, Thailand from 04-06 May 2005. It contains reviews of the experiences of the health sector and early recovery following the Earthquake and Tsunami with emphasis on what was done well and what could have been done better and the lessons learned that can be incorporated into actions that will mitigate the damage created by future events. It outlines the national and international responses and recovery and the actions taken and not taken by the international community in support of the countries affected. Specific issues addressed include: (1) needs assessments; (2) coordination; (3) filling gaps in essential services, and (4) capacity building at the country level. Each of these aspects is analyzed as to its: (1) appropriateness; (2) adequacy; (3) effectiveness; (4) efficiency; and (5) connectedness. Much of what occurred provided benefits to the stricken population, but there is substantial room for improvement through implementation of the lessons learned. These lessons must be converted into actions in order to mitigate the damage sustained and to enhance our responses to the damage from future events.

An overview of the geotechnical damage brought by the 2016 Kumamoto Earthquake, Japan

USGS Publications Warehouse

Hemanta Hazarika,; Takaji Kokusho,; Kayen, Robert E.; Dashti, Shideh; Yutaka Tanoue,; Shuuichi Kuroda and Kentaro Kuribayashi,; Daisuke Matsumoto,; Furuichi, Hideo

2016-01-01

The 2016 Kumamoto earthquake with a moment magnitude of 7.0 (Japanese intensity = 7) that struck on April 16 brought devastation in many areas of Kumamoto Prefecture and partly in Oita Prefecture in Kyushu Region, Japan. The earthquake succeeds a foreshock of magnitude 6.5 (Japanese intensity = 7) on April 14. The authors conducted two surveys on the devastated areas: one during April 16-17, and the other during May 11-14. This report summarizes the damage brought to geotechnical structures by the two consecutive earthquakes within a span of twenty-eight hours. This report highlights some of the observed damage and identifies reasons for such damage. The geotechnical challenges towards mitigation of losses from such earthquakes are also suggested.

Understanding household preferences for hurricane risk mitigation information: evidence from survey responses.

PubMed

Chatterjee, Chiradip; Mozumder, Pallab

2014-06-01

Risk information is critical to adopting mitigation measures, and seeking risk information is influenced by a variety of factors. An essential component of the recently adopted My Safe Florida Home (MSFH) program by the State of Florida is to provide homeowners with pertinent risk information to facilitate hurricane risk mitigation activities. We develop an analytical framework to understand household preferences for hurricane risk mitigation information through allowing an intensive home inspection. An empirical analysis is used to identify major drivers of household preferences to receive personalized information regarding recommended hurricane risk mitigation measures. A variety of empirical specifications show that households with home insurance, prior experience with damages, and with a higher sense of vulnerability to be affected by hurricanes are more likely to allow inspection to seek information. However, households with more members living in the home and households who live in manufactured/mobile homes are less likely to allow inspection. While findings imply MSFH program's ability to link incentives offered by private and public agencies in promoting mitigation, households that face a disproportionately higher level of risk can get priority to make the program more effective. © 2014 Society for Risk Analysis.

A review of risk perceptions and other factors that influence flood mitigation behavior.

PubMed

Bubeck, P; Botzen, W J W; Aerts, J C J H

2012-09-01

In flood risk management, a shift can be observed toward more integrated approaches that increasingly address the role of private households in implementing flood damage mitigation measures. This has resulted in a growing number of studies into the supposed positive relationship between individual flood risk perceptions and mitigation behavior. Our literature review shows, however, that, actually, this relationship is hardly observed in empirical studies. Two arguments are provided as an explanation. First, on the basis of protection motivation theory, a theoretical framework is discussed suggesting that individuals' high-risk perceptions need to be accompanied by coping appraisal to result in a protective response. Second, it is pointed out that possible feedback from already-adopted mitigation measures on risk perceptions has hardly been considered by current studies. In addition, we also provide a review of factors that drive precautionary behavior other than risk perceptions. It is found that factors such as coping appraisal are consistently related to mitigation behavior. We conclude, therefore, that the current focus on risk perceptions as a means to explain and promote private flood mitigation behavior is not supported on either theoretical or empirical grounds. © 2012 Society for Risk Analysis.

Hawkmoths use nectar sugar to reduce oxidative damage from flight.

PubMed

Levin, E; Lopez-Martinez, G; Fane, B; Davidowitz, G

2017-02-17

Nectar-feeding animals have among the highest recorded metabolic rates. High aerobic performance is linked to oxidative damage in muscles. Antioxidants in nectar are scarce to nonexistent. We propose that nectarivores use nectar sugar to mitigate the oxidative damage caused by the muscular demands of flight. We found that sugar-fed moths had lower oxidative damage to their flight muscle membranes than unfed moths. Using respirometry coupled with δ 13 C analyses, we showed that moths generate antioxidant potential by shunting nectar glucose to the pentose phosphate pathway (PPP), resulting in a reduction in oxidative damage to the flight muscles. We suggest that nectar feeding, the use of PPP, and intense exercise are causally linked and have allowed the evolution of powerful fliers that feed on nectar. Copyright © 2017, American Association for the Advancement of Science.

Approach for Assessing Direct Flood Damages

NASA Astrophysics Data System (ADS)

Gaňová, Lenka; Zeleňáková, Martina; Słyś, Daniel; Purcz, Pavol

2014-11-01

This article presents a methodological approach to flood direct tangible damage - damage to assets and direct intangible damage - environmental damage and loss of life assessment. The assessment of flood risk is an essential part of the risk management approach, which is the conceptual basis for the EU directive 2007/60/ES on the assessment and management of flood risk. The purpose of this directive is to establish a framework for the assessment and management of flood risk, aiming at the reduction of the adverse consequences for human health, the environment, cultural heritage and economic activity associated with flood in the community. Overall, an accurate estimation of negative effects on assets, environment and people is important in order to be able to determine the economy, environmental and social flood risk level in a system and the effects of risk mitigation measures.

Positive train control desense mitigation test : research phase 1.

DOT National Transportation Integrated Search

2016-05-01

Final report for Positive Train Control (PTC) Desense Mitigation Test Research project includes description of Northeast Corridor (NEC) PTC deployments, PTC radio desense scenarios, PTC radio desense mitigation approaches, PTC radio desense mitigatio...

30 CFR 219.410 - What does this subpart contain?

Code of Federal Regulations, 2010 CFR

2010-07-01

... coastal protection, including conservation, coastal restoration, hurricane protection, and infrastructure directly affected by coastal wetland losses. (2) Mitigation of damage to fish, wildlife, or natural... coastal political subdivisions within those States; and to the Land and Water Conservation Fund. Shared...

Optimal bridge retrofit strategy to enhance disaster resilience of highway transportation systems.

DOT National Transportation Integrated Search

2014-07-01

This study evaluated the resilience of highway bridges under the multihazard scenario of earthquake in the presence of : flood-induced scour. To mitigate losses incurred from bridge damage during extreme events, bridge retrofit strategies are : selec...

Mitigation strategies for early-age shrinkage cracking in bridge decks.

DOT National Transportation Integrated Search

2010-04-01

Early-age shrinkage cracking has been observed in many concrete bridge decks in Washington State and elsewhere around the U.S. The cracking increases the effects of freeze-thaw damage, spalling, and corrosion of steel reinforcement, thus resulting in...

Induced seismicity and carbon storage: Risk assessment and mitigation strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Joshua A.; Foxall, William; Bachmann, Corinne

Geologic carbon storage (GCS) is widely recognized as an important strategy to reduce atmospheric carbon dioxide (CO 2) emissions. Like all technologies, however, sequestration projects create a number of potential environmental and safety hazards that must be addressed. These include earthquakes—from microseismicity to large, damaging events—that can be triggered by altering pore-pressure conditions in the subsurface. To date, measured seismicity due to CO 2 injection has been limited to a few modest events, but the hazard exists and must be considered. There are important similarities between CO 2 injection and fluid injection from other applications that have induced significant events—e.g.more » geothermal systems, waste-fluid injection, hydrocarbon extraction, and others. There are also important distinctions among these technologies that should be considered in a discussion of seismic hazard. This report focuses on strategies for assessing and mitigating risk during each phase of a CO 2 storage project. Four key risks related to fault reactivation and induced seismicity were considered. Induced slip on faults could potentially lead to: (1) infrastructure damage, (2) a public nuisance, (3) brine-contaminated drinking water, and (4) CO 2-contaminated drinking water. These scenarios lead to different types of damage—to property, to drinking water quality, or to the public welfare. Given these four risks, this report focuses on strategies for assessing (and altering) their likelihoods of occurrence and the damage that may result. This report begins with an overview of the basic physical mechanisms behind induced seismicity. This science basis—and its gaps—is crucial because it forms the foundation for risk assessment and mitigation. Available techniques for characterizing and monitoring seismic behavior are also described. Again, this technical basis—and its limitations—must be factored into the risk assessment and mitigation approach. A phased approach to risk management is then introduced. The basic goal of the phased approach is to constantly adapt site operations to current conditions and available characterization data. The remainder of the report then focuses in detail on different components of the monitoring, risk assessment, and mitigation strategies. Issues in current seismic risk assessment methods that must be modified to address induce seismicity are highlighted. The report then concludes with several specific recommendations for operators and regulatory authorities to consider when selecting, permitting, and operating a storage project.« less

Surface heat flux feedback controlled impurity seeding experiments with Alcator C-Mod’s high-Z vertical target plate divertor: performance, limitations and implications for fusion power reactors

NASA Astrophysics Data System (ADS)

Brunner, D.; Wolfe, S. M.; LaBombard, B.; Kuang, A. Q.; Lipschultz, B.; Reinke, M. L.; Hubbard, A.; Hughes, J.; Mumgaard, R. T.; Terry, J. L.; Umansky, M. V.; The Alcator C-Mod Team

2017-08-01

The Alcator C-Mod team has recently developed a feedback system to measure and control surface heat flux in real-time. The system uses real-time measurements of surface heat flux from surface thermocouples and a pulse-width modulated piezo valve to inject low-Z impurities (typically N2) into the private flux region. It has been used in C-Mod to mitigate peak surface heat fluxes  >40 MW m-2 down to  <10 MW m-2 while maintaining excellent core confinement, H 98  >  1. While the system works quite well under relatively steady conditions, use of it during transients has revealed important limitations on feedback control of impurity seeding in conventional vertical target plate divertors. In some cases, the system is unable to avoid plasma reattachment to the divertor plate or the formation of a confinement-damaging x-point MARFE. This is due to the small operational window for mitigated heat flux in the parameters of incident plasma heat flux, plasma density, and impurity density as well as the relatively slow response of the impurity gas injection system compared to plasma transients. Given the severe consequences for failure of such a system to operate reliably in a reactor, there is substantial risk that the conventional vertical target plate divertor will not provide an adequately controllable system in reactor-class devices. These considerations motivate the need to develop passively stable, highly compliant divertor configurations and experimental facilities that can test such possible solutions.

L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines.

PubMed

Salama, Samir A; Arab, Hany H; Omar, Hany A; Gad, Hesham S; Abd-Allah, Gamil M; Maghrabi, Ibrahim A; Al Robaian, Majed M

2018-04-01

UVA comprises more than 90% of the solar UV radiation reaching the Earth. Artificial lightening lamps have also been reported to emit significant amounts of UVA. Exposure to UVA has been associated with dermatological disorders including skin cancer. At the molecular level, UVA damages different cellular biomolecules and triggers inflammatory responses. The current study was devoted to investigate the potential protective effect of L-carnitine against UVA-induced skin tissue injury using rats as a mammalian model. Rats were distributed into normal control group (NC), L-carnitine control group (LC), UVA-Exposed group (UVA), and UVA-Exposed and L-carnitine-treated group (UVA-LC). L-carnitine significantly attenuated UVA-induced elevation of the DNA damage markers 8-oxo-2'-deoxyguanosine (8-oxo-dG) and cyclobutane pyrimidine dimers (CPDs) as well as decreased DNA fragmentation and the activity of the apoptotic marker caspase-3. In addition, L-carnitine substantially reduced the levels of lipid peroxidation marker (TBARS) and protein oxidation marker (PCC) and significantly elevated the levels of the total antioxidant capacity (TAC) and the antioxidant reduced glutathione (GSH) in the skin tissues. Interestingly, L-carnitine upregulated the level of the DNA repair protein proliferating cell nuclear antigen (PCNA). Besides it mitigated the UVA-induced activation of the oxidative stress-sensitive signaling protein p38 and its downstream target c-Fos. Moreover, L-carnitine significantly downregulated the levels of the early response proinflammatory cytokines TNF-α, IL-6, and IL-1β. Collectively, our results highlight, for the first time, the potential attenuating effects of L-carnitine on UVA-induced skin tissue injury in rats that is potentially mediated through suppression of UVA-induced oxidative stress and inflammatory responses. Copyright © 2018 Elsevier B.V. All rights reserved.

Full-Scaled Advanced Systems Testbed: Ensuring Success of Adaptive Control Research Through Project Lifecycle Risk Mitigation

NASA Technical Reports Server (NTRS)

Pavlock, Kate M.

2011-01-01

The National Aeronautics and Space Administration's Dryden Flight Research Center completed flight testing of adaptive controls research on the Full-Scale Advance Systems Testbed (FAST) in January of 2011. The research addressed technical challenges involved with reducing risk in an increasingly complex and dynamic national airspace. Specific challenges lie with the development of validated, multidisciplinary, integrated aircraft control design tools and techniques to enable safe flight in the presence of adverse conditions such as structural damage, control surface failures, or aerodynamic upsets. The testbed is an F-18 aircraft serving as a full-scale vehicle to test and validate adaptive flight control research and lends a significant confidence to the development, maturation, and acceptance process of incorporating adaptive control laws into follow-on research and the operational environment. The experimental systems integrated into FAST were designed to allow for flexible yet safe flight test evaluation and validation of modern adaptive control technologies and revolve around two major hardware upgrades: the modification of Production Support Flight Control Computers (PSFCC) and integration of two, fourth-generation Airborne Research Test Systems (ARTS). Post-hardware integration verification and validation provided the foundation for safe flight test of Nonlinear Dynamic Inversion and Model Reference Aircraft Control adaptive control law experiments. To ensure success of flight in terms of cost, schedule, and test results, emphasis on risk management was incorporated into early stages of design and flight test planning and continued through the execution of each flight test mission. Specific consideration was made to incorporate safety features within the hardware and software to alleviate user demands as well as into test processes and training to reduce human factor impacts to safe and successful flight test. This paper describes the research configuration, experiment functionality, overall risk mitigation, flight test approach and results, and lessons learned of adaptive controls research of the Full-Scale Advanced Systems Testbed.

Crash avoidance potential of four large truck technologies.

PubMed

Jermakian, Jessica S

2012-11-01

The objective of this paper was to estimate the maximum potential large truck crash reductions in the United States associated with each of four crash avoidance technologies: side view assist, forward collision warning/mitigation, lane departure warning/prevention, and vehicle stability control. Estimates accounted for limitations of current systems. Crash records were extracted from the 2004-08 files of the National Automotive Sampling System General Estimates System (NASS GES) and the Fatality Analysis Reporting System (FARS). Crash descriptors such as location of damage on the vehicle, road characteristics, time of day, and precrash maneuvers were reviewed to determine whether the information or action provided by each technology potentially could have prevented the crash. Of the four technologies, side view assist had the greatest potential for preventing large truck crashes of any severity; the technology is potentially applicable to 39,000 crashes in the United States each year, including 2000 serious and moderate injury crashes and 79 fatal crashes. Vehicle stability control is another promising technology, with the potential to prevent or mitigate up to 31,000 crashes per year including more serious crashes--up to 7000 moderate-to-serious injury crashes and 439 fatal crashes per year. Vehicle stability control could prevent or mitigate up to 20 and 11 percent of moderate-to-serious injury and fatal large truck crashes, respectively. Forward collision warning has the potential to prevent as many as 31,000 crashes per year, including 3000 serious and moderate injury crashes and 115 fatal crashes. Finally, 10,000 large truck crashes annually were relevant to lane departure warning/prevention systems. Of these, 1000 involved serious and moderate injuries and 247 involved fatal injuries. There is great potential effectiveness for truck-based crash avoidance systems. However, it is yet to be determined how drivers will interact with the systems. Actual effectiveness of crash avoidance systems will not be known until sufficient real-world experience has been gained. Copyright © 2012 Elsevier Ltd. All rights reserved.

Vulnerability of bridges to scour: insights from an international expert elicitation workshop

NASA Astrophysics Data System (ADS)

Lamb, Rob; Aspinall, Willy; Odbert, Henry; Wagener, Thorsten

2017-08-01

Scour (localised erosion) during flood events is one of the most significant threats to bridges over rivers and estuaries, and has been the cause of numerous bridge failures, with damaging consequences. Mitigation of the risk of bridges being damaged by scour is therefore important to many infrastructure owners, and is supported by industry guidance. Even after mitigation, some residual risk remains, though its extent is difficult to quantify because of the uncertainties inherent in the prediction of scour and the assessment of the scour risk. This paper summarises findings from an international expert workshop on bridge scour risk assessment that explores uncertainties about the vulnerability of bridges to scour. Two specialised structured elicitation methods were applied to explore the factors that experts in the field consider important when assessing scour risk and to derive pooled expert judgements of bridge failure probabilities that are conditional on a range of assumed scenarios describing flood event severity, bridge and watercourse types and risk mitigation protocols. The experts' judgements broadly align with industry good practice, but indicate significant uncertainty about quantitative estimates of bridge failure probabilities, reflecting the difficulty in assessing the residual risk of failure. The data and findings presented here could provide a useful context for the development of generic scour fragility models and their associated uncertainties.

Implications of climate change damage for agriculture: sectoral evidence from Pakistan.

PubMed

Ahmed, Adeel; Devadason, Evelyn S; Al-Amin, Abul Quasem

2016-10-01

This paper gives a projection of the possible damage of climate change on the agriculture sector of Pakistan for the period 2012-2037, based on a dynamic approach, using an environment-related applied computable general equilibrium model (CGE). Climate damage projections depict an upward trend for the period of review and are found to be higher than the global average. Further, the damage to the agricultural sector exceeds that for the overall economy. By sector, climatic damage disproportionately affects the major and minor crops, livestock and fisheries. The largest losses following climate change, relative to the other agricultural sectors, are expected for livestock. The reason for this is the orthodox system of production for livestock, with a low adaptability to negative shocks of climate change. Overall, the findings reveal the high exposure of the agriculture sector to climate damage. In this regard, policymakers in Pakistan should take seriously the effects of climate change on agriculture and consider suitable technology to mitigate those damages.

Workshop on Smart Structures (1st) Held at The University of Texas at Arlington on September 22-24 1993. Collection of Extended Abstracts

DTIC Science & Technology

1994-06-01

and Optimization of Composite and Sandwich Panels Using Piezoelectric Stiffeners-Actuators" Z. Chaudhry, T. Ganino and Craig A. Rogers, Virginia...Mitigation’ Abu S. Islam and Kevin C. Craig, Rensselaer Polytechnic Institute * ’Damage Detection in Composite Structures Using Piezoelectric Materials" H...Singh, L. Y. Lo and J. S. Sirkis, University of Maryland "Meaningful Damage Evolution Tracking In Composites Using Structurally Embedded Optical Fiber

Evaluation and Repair of War-Damaged Port Facilities. Report 3. Concepts for Expedient War-Damage Repair of Pier and Wharf Decking

DTIC Science & Technology

1987-06-01

calculations) Timber or laminated wood could be used to provide a deck for an expedient repair. Forest products may be the materials of choice because of...splits in the wood near the end of the timber. This problem may be mitigated by nail or glue laminating smaller members into mats of the desired...explanation of possible uses for laminated forest products in expedient port construction. As mentioned in the discussion con-^ cerning prefabricated

Complement Depletion Protects Lupus-prone Mice from Ischemia-reperfusion-initiated Organ Injury

DTIC Science & Technology

2012-10-25

injury, we sought to evaluate whether complement inhibition mitigates organ damage. We found that complement deple- tion with cobra venom factor... venom factor and C5a receptor antagonist were able to protect mice from local tissue damage, treatment with C5a receptor antagonist was not able to...Complement depletion or blockage of the complement pathway using molecules such as cobra venom factor (CVF) (24, 33) and C5a receptor antagonists (C5aRA

CLOSE AIR SUPPORT (CAS) FOR COUNTERINSURGENCY (COIN) AND THE UPWARD TRAJECTORY OF UNMANNED AIRCRAFT SYSTEMS (UAS): NAVIGATING THE UNDISCOVERED DOMAIN

DTIC Science & Technology

2015-10-01

collateral damage. Further mitigating collateral damage, “…the SDB Focused Lethality Munition (FLM) variant incorporates a carbon fiber composite ...Effectiveness Modern attack helicopters execute the CAS mission with various standoff weapons. RW assets are slow moving and susceptible to MANPADS and...small arms fire, and attack helicopters used for CAS are primarily in a medium or low threat environment where enemy air defenses are weak or not

Practical macromolecular cryocrystallography

PubMed Central

Pflugrath, J. W.

2015-01-01

Cryocrystallography is an indispensable technique that is routinely used for single-crystal X-ray diffraction data collection at temperatures near 100 K, where radiation damage is mitigated. Modern procedures and tools to cryoprotect and rapidly cool macromolecular crystals with a significant solvent fraction to below the glass-transition phase of water are reviewed. Reagents and methods to help prevent the stresses that damage crystals when flash-cooling are described. A method of using isopentane to assess whether cryogenic temperatures have been preserved when dismounting screened crystals is also presented. PMID:26057787

Flood damage data gathering: procedures and use

NASA Astrophysics Data System (ADS)

Molinari, D.; Aronica, G. T.; Ballio, F.; Berni, N.; Pandolfo, C.

2012-04-01

Damage data represents the basis on which flood risk models, re-founding schemes and mitigation activities are grounded on. Nevertheless damage data have been collected so far mainly at the national-regional scale; few databases exist at the local scale and, even if present, no standard exist for their development. On the contrary, risk analyses and mitigation strategies are usually carried out at local scale. This contribution describes the ongoing activity to collect and analyze local damage data coming from past events with recently hit Umbria an Sicily regions (central and south part of Italy respectively). Data from past events will be discussed from two different perspectives. In Italy, procedures to gather damage data after a flood are defined by law. According to this, authors will first question whether or not collected data are suitable to give an exhaustive representation of the total impact the events had on the affected territories. As regards, suggestions are provided about how gathering procedures can improve. On the other hand, collected data will be discussed with respect to their implementation in the definition of depth-damage curves for the Italian context; literature review highlights indeed that no curves are available for Italy. Starting from the knowledge of observed hazard intensity and damage data, available curves from other countries are validated, the objective being to reduce the uncertainty which currently characterise damage estimation. Indeed, a variety of curves can be found in literature and the choice of one curve in place of another can change damage assessment results of one order of magnitude. The validation procedure will allow, in its turn, to face a secondary but key question for the contribution, being the identification of those hazard and vulnerability features that should be recorded and kept updated in a local GIS database to support risk modelling, funding and management. The two areas under investigation are prone to different types of hazard: flash floods with high debris concentration are typical of the Sicilian area whilst riverine floods are common in the Umbria region. This way, reasoning can be made with respect to different hazard and vulnerability aspects.

Hawaiian cultural influences on support for lava flow hazard mitigation measures during the January 1960 eruption of Kīlauea volcano, Kapoho, Hawai‘i

NASA Astrophysics Data System (ADS)

Gregg, C. E.; Houghton, B. F.; Paton, D.; Swanson, D. A.; Lachman, R.; Bonk, W. J.

2008-05-01

In 1960, Kīlauea volcano in Hawaii erupted, destroying most of the village of Kapoho and forcing evacuation of its approximately 300 residents. A large and unprecedented social science survey was undertaken during the eruption to develop an understanding of human behavior, beliefs, and coping strategies among the adult evacuees ( n = 160). Identical studies were also performed in three control towns located at varying distances from the eruption site ( n = 478). During these studies data were collected that characterized ethnic grouping and attitudes toward Hawaiian cultural issues such as belief in Pele and two lava flow mitigation measures—use of barriers and bombs to influence the flow of lava, but the data were never published. Using these forgotten data, we examined the relationship between Hawaiian cultural issues and attitudes toward the use of barriers and bombs as mitigation strategies to protect Kapoho. On average, 72% of respondents favored the construction of earthen barriers to hold back or divert lava and protect Kapoho, but far fewer agreed with the military's use of bombs (14%) to protect Kapoho. In contrast, about one-third of respondents conditionally agreed with the use of bombs. It is suggested that local participation in the bombing strategy may explain the increased conditional acceptance of bombs as a mitigation tool, although this can not be conclusively demonstrated. Belief in Pele and being of Hawaiian ethnicity did not reduce support for the use of barriers, but did reduce support for bombs in both bombing scenarios. The disparity in levels of acceptance of barriers versus bombing and of one bombing strategy versus another suggests that historically public attitudes toward lava flow hazard mitigation strategies were complex. A modern comparative study is needed before the next damaging eruption to inform debates and decisions about whether or not to interfere with the flow of lava. Recent changes in the current eruption of Kīlauea make this a timely topic.

30 CFR 519.410 - What does this subpart contain?

Code of Federal Regulations, 2012 CFR

2012-07-01

... for the purposes of coastal protection, including conservation, coastal restoration, hurricane protection, and infrastructure directly affected by coastal wetland losses. (2) Mitigation of damage to fish... States); to eligible coastal political subdivisions within those States; and to the Land and Water...

30 CFR 519.410 - What does this subpart contain?

Code of Federal Regulations, 2014 CFR

2014-07-01

... for the purposes of coastal protection, including conservation, coastal restoration, hurricane protection, and infrastructure directly affected by coastal wetland losses. (2) Mitigation of damage to fish... States); to eligible coastal political subdivisions within those States; and to the Land and Water...

30 CFR 519.410 - What does this subpart contain?

Code of Federal Regulations, 2013 CFR

2013-07-01

... for the purposes of coastal protection, including conservation, coastal restoration, hurricane protection, and infrastructure directly affected by coastal wetland losses. (2) Mitigation of damage to fish... States); to eligible coastal political subdivisions within those States; and to the Land and Water...

CORS 911 : continuously operating reference stations for the Bayou Corne sinkhole.

DOT National Transportation Integrated Search

2013-06-01

The sinkhole located near the Napoleonville Salt Dome in Assumption Parish, Louisiana : threatens the stability of LA 70 a state maintained route. In order to mitigate the : possible damaging eff ects of the sinkhole to the route and address publ...

Detector Damage at X-Ray Free-Electron Laser Sources

NASA Astrophysics Data System (ADS)

Blaj, G.; Carini, G.; Carron, S.; Haller, G.; Hart, P.; Hasi, J.; Herrmann, S.; Kenney, C.; Segal, J.; Stan, C. A.; Tomada, A.

2016-06-01

Free-electron lasers (FELs) opened a new window on imaging the motion of atoms and molecules. At SLAC, FEL experiments are performed at LCLS using 120 Hz pulses with 1012 to 1013 photons in 10 fs (billions of times brighter than at the most powerful synchrotrons). Concurrently, users and staff operate under high pressure due to flexible and often rapidly changing setups and low tolerance for system malfunction. This extreme detection environment raises unique challenges, from obvious to surprising, and leads to treating detectors as consumables. We discuss in detail the detector damage mechanisms observed in 7 years of operation at LCLS, together with the corresponding damage mitigation strategies and their effectiveness. Main types of damage mechanisms already identified include: (1) x-ray radiation damage (from “catastrophic” to “classical”), (2) direct and indirect damage caused by optical lasers, (3) sample induced damage, (4) vacuum related damage, (5) high-pressure environment. In total, 19 damage mechanisms have been identified. We also present general strategies for reducing damage risk or minimizing the impact of detector damage on the science program. These include availability of replacement parts and skilled operators and also careful planning, incident investigation resulting in updated designs, procedures and operator training.

Enhancing radiation tolerance by controlling defect mobility and migration pathways in multicomponent single-phase alloys

NASA Astrophysics Data System (ADS)

Lu, Chenyang; Niu, Liangliang; Chen, Nanjun; Jin, Ke; Yang, Taini; Xiu, Pengyuan; Zhang, Yanwen; Gao, Fei; Bei, Hongbin; Shi, Shi; He, Mo-Rigen; Robertson, Ian M.; Weber, William J.; Wang, Lumin

2016-12-01

A grand challenge in material science is to understand the correlation between intrinsic properties and defect dynamics. Radiation tolerant materials are in great demand for safe operation and advancement of nuclear and aerospace systems. Unlike traditional approaches that rely on microstructural and nanoscale features to mitigate radiation damage, this study demonstrates enhancement of radiation tolerance with the suppression of void formation by two orders magnitude at elevated temperatures in equiatomic single-phase concentrated solid solution alloys, and more importantly, reveals its controlling mechanism through a detailed analysis of the depth distribution of defect clusters and an atomistic computer simulation. The enhanced swelling resistance is attributed to the tailored interstitial defect cluster motion in the alloys from a long-range one-dimensional mode to a short-range three-dimensional mode, which leads to enhanced point defect recombination. The results suggest design criteria for next generation radiation tolerant structural alloys.

Mitigating the Impact of Bats in Historic Churches: The Response of Natterer’s Bats Myotis nattereri to Artificial Roosts and Deterrence

PubMed Central

Zeale, Matt R. K.; Bennitt, Emily; Newson, Stuart E.; Packman, Charlotte; Browne, William J.; Harris, Stephen; Jones, Gareth; Stone, Emma

2016-01-01

Bats frequently roost in historic churches, and these colonies are of considerable conservation value. Inside churches, bat droppings and urine can cause damage to the historic fabric of the building and to items of cultural significance. In extreme cases, large quantities of droppings can restrict the use of a church for worship and/or other community functions. In the United Kingdom, bats and their roosts are protected by law, and striking a balance between conserving the natural and cultural heritage can be a significant challenge. We investigated mitigation strategies that could be employed in churches and other historic buildings to alleviate problems caused by bats without adversely affecting their welfare or conservation status. We used a combination of artificial roost provision and deterrence at churches in Norfolk, England, where significant maternity colonies of Natterer’s bats Myotis nattereri damage church features. Radio-tracking data and population modelling showed that excluding M. nattereri from churches is likely to have a negative impact on their welfare and conservation status, but that judicious use of deterrents, especially high intensity ultrasound, can mitigate problems caused by bats. We show that deterrence can be used to move bats humanely from specific roosting sites within a church and limit the spread of droppings and urine so that problems to congregations and damage to cultural heritage can be much reduced. In addition, construction of bespoke roost spaces within churches can allow bats to continue to roost within the fabric of the building without flying in the church interior. We highlight that deterrence has the potential to cause serious harm to M. nattereri populations if not used judiciously, and so the effects of deterrents will need careful monitoring, and their use needs strict regulation. PMID:26771548

Retrofitting for watershed drainage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, D.B.; Heaney, J.P.

1991-09-01

Over the past 8 years, degradation in Florida's Indian River Lagoon has taken the form of fish kills, reduced viable recreational and commercial fisheries, and loss of seagrass beds. Stormwater drainage practices in the watershed have been identified as the primary culprit in the slow demise of the lagoon. Specific drainage problems include an increased volume of freshwater runoff to the estuarine receiving water and deposition of organic sediments, reduced water clarity because of increased discharge of suspended solids and tea colored' groundwater - a result of drainage-canal-induced land dewatering, and eutrophication caused by nutrient loadings. In addition, poor flushingmore » in lagoon segments makes runoff impacts even more damaging to the ecosystem. Recently, the lagoon has received national, regional, state, and local attention over its degradation and citizens' action and multi-agency efforts to restore it. To mitigate damage to the Indian River lagoon, agencies are considering alternatives such as retrofitting to reduce pollutant loads and implementing a more comprehensive watershed approach to stormwater management instead of individual controls on new development currently widely practiced. A comprehensive, long-term watershed control approach avoids unnecessary construction expenses, encourages cost-effective tradeoffs based on specific objectives, facilities performance monitoring, and accounts for cumulative impacts of continued growth in the watershed.« less

40 CFR 93.125 - Enforceability of design concept and scope and project-level mitigation and control measures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Transit Laws § 93.125 Enforceability of design concept and scope and project-level mitigation and control... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Enforceability of design concept and scope and project-level mitigation and control measures. 93.125 Section 93.125 Protection of Environment...

40 CFR 93.125 - Enforceability of design concept and scope and project-level mitigation and control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Transit Laws § 93.125 Enforceability of design concept and scope and project-level mitigation and control... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Enforceability of design concept and scope and project-level mitigation and control measures. 93.125 Section 93.125 Protection of Environment...

40 CFR 93.125 - Enforceability of design concept and scope and project-level mitigation and control measures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Transit Laws § 93.125 Enforceability of design concept and scope and project-level mitigation and control... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Enforceability of design concept and scope and project-level mitigation and control measures. 93.125 Section 93.125 Protection of Environment...

40 CFR 93.125 - Enforceability of design concept and scope and project-level mitigation and control measures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Transit Laws § 93.125 Enforceability of design concept and scope and project-level mitigation and control... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Enforceability of design concept and scope and project-level mitigation and control measures. 93.125 Section 93.125 Protection of Environment...

40 CFR 93.125 - Enforceability of design concept and scope and project-level mitigation and control measures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Transit Laws § 93.125 Enforceability of design concept and scope and project-level mitigation and control... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Enforceability of design concept and scope and project-level mitigation and control measures. 93.125 Section 93.125 Protection of Environment...

Mitigation of commutation failures in LCC-HVDC systems based on superconducting fault current limiters

NASA Astrophysics Data System (ADS)

Lee, Jong-Geon; Khan, Umer Amir; Lee, Ho-Yun; Lim, Sung-Woo; Lee, Bang-Wook

2016-11-01

Commutation failure in line commutated converter based HVDC systems cause severe damages on the entire power grid system. For LCC-HVDC, thyristor valves are turned on by a firing signal but turn off control is governed by the external applied AC voltage from surrounding network. When the fault occurs in AC system, turn-off control of thyristor valves is unavailable due to the voltage collapse of point of common coupling (PCC), which causes the commutation failure in LCC-HVDC link. Due to the commutation failure, the power transfer interruption, dc voltage drop and severe voltage fluctuation in the AC system could be occurred. In a severe situation, it might cause the protection system to block the valves. In this paper, as a solution to prevent the voltage collapse on PCC and to limit the fault current, the application study of resistive superconducting fault current limiter (SFCL) on LCC-HVDC grid system was performed with mathematical and simulation analyses. The simulation model was designed by Matlab/Simulink considering Haenam-Jeju HVDC power grid in Korea which includes conventional AC system and onshore wind farm and resistive SFCL model. From the result, it was observed that the application of SFCL on LCC-HVDC system is an effective solution to mitigate the commutation failure. And then the process to determine optimum quench resistance of SFCL which enables the recovery of commutation failure was deeply investigated.

Refractory Materials for Flame Deflector Protection System Corrosion Control: Coatings Systems Literature Survey

NASA Technical Reports Server (NTRS)

Calle, Luz M.; Hintze, Paul E.; Parlier, Christopher R.; Sampson, Jeffrey W.; Coffman, Brekke E.; Coffman, Brekke E.; Curran, Jerome P.; Kolody, Mark R.; Whitten, Mary; Perisich, Steven;

Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis

PubMed Central

Gause, William C; Maizels, Rick M

2016-01-01

Important insights have recently been gained in our understanding of the intricate relationship in the intestinal milieu between the vertebrate host mucosal immune response, commensal bacteria, and helminths. Helminths are metazoan worms (macrobiota) and trigger immune responses that include potent regulatory components capable of controlling harmful inflammation, protecting barrier function and mitigating tissue damage. They can secrete a variety of products that directly affect immune regulatory function but they also have the capacity to influence the composition of microbiota, which can also then impact immune function. Conversely, changes in microbiota can affect susceptibility to helminth infection, indicating that crosstalk between these two disparate groups of endobiota can play an essential role in host intestinal immune function and homeostasis. PMID:27116368

Future property damage from flooding: sensitivities to economy and climate change

DOE PAGES

Liu, Jing; Hertel, Thomas; Diffenbaugh, Noah; ...

2015-08-09

Using a unique dataset for Indiana counties during the period 1995-2012, we estimate the effects of flood hazard, asset exposure, and social vulnerability on property damage. This relationship then is combined with the expected level of future flood risks to project property damage from flooding in 2030 under various scenarios. We compare these scenario projections to identify which risk management strategy offers the greatest potential to mitigate flooding loss. Results show that by 2030, county level flooding hazard measured by extreme flow volume and frequency will increase by an average of 16.2% and 7.4%, respectively. The total increase in propertymore » damages projected under different model specifications range from 13.3% to 20.8%. Across models future damages consistently exhibit the highest sensitivity to future increases in asset exposure, reinforcing the importance of non-structural measures in managing floodplain development.« less

Assessment of Crop Damage by Protected Wild Mammalian Herbivores on the Western Boundary of Tadoba-Andhari Tiger Reserve (TATR), Central India

PubMed Central

Bayani, Abhijeet; Tiwade, Dilip; Dongre, Ashok; Dongre, Aravind P.; Phatak, Rasika; Watve, Milind

2016-01-01

Crop raiding by wild herbivores close to an area of protected wildlife is a serious problem that can potentially undermine conservation efforts. Since there is orders of magnitude difference between farmers’ perception of damage and the compensation given by the government, an objective and realistic estimate of damage was found essential. We employed four different approaches to estimate the extent of and patterns in crop damage by wild herbivores along the western boundary of Tadoba-Andhari Tiger Reserve in the state of Maharashtra, central India. These approaches highlight different aspects of the problem but converge on an estimated damage of over 50% for the fields adjacent to the forest, gradually reducing in intensity with distance. We found that the visual damage assessment method currently employed by the government for paying compensation to farmers was uncorrelated to and grossly underestimated actual damage. The findings necessitate a radical rethinking of policies to assess, mitigate as well as compensate for crop damage caused by protected wildlife species. PMID:27093293

Mitigation of formalin-induced RNA damage to advance whole transcriptomic analyses of archival tissues

EPA Science Inventory

Leveraging the use of biorepository samples for genomic analyses holds huge implications for human health, including applications in pathway identification, biomarker discovery, and tumor profiling for precision medicine. However, there is a need for better ways to reduce nucleic...

78 FR 54801 - Gulf Coast Restoration Trust Fund

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

..., including port infrastructure. (g) Coastal flood protection and related infrastructure. (h) Promotion of... protection of natural resources, mitigation of damage to fish and wildlife, and workforce development and job..., marine and wildlife habitats, beaches, coastal wetlands, and economy of the Gulf Coast. The Council will...

Damage Detection and Mitigation in Open Collaboration Applications

ERIC Educational Resources Information Center

West, Andrew G.

2013-01-01

Collaborative functionality is changing the way information is amassed, refined, and disseminated in online environments. A subclass of these systems characterized by "open collaboration" uniquely allow participants to "modify" content with low barriers-to-entry. A prominent example and our case study, English Wikipedia,…

Seismic vulnerability of Oregon state highway bridges : mitigation strategies to reduce major mobility risks.

DOT National Transportation Integrated Search

2009-11-01

The Oregon Department of Transportation and Portland State University evaluated the seismic : vulnerability of state highway bridges in western Oregon. The study used a computer program : called REDARS2 that simulated the damage to bridges within a t...

Precision resection of lung cancer in a sheep model using ultrashort laser pulses

NASA Astrophysics Data System (ADS)

Beck, Rainer J.; Mohanan, Syam Mohan P. C.; Góra, Wojciech S.; Cousens, Chris; Finlayson, Jeanie; Dagleish, Mark P.; Griffiths, David J.; Shephard, Jonathan D.

2017-02-01

Recent developments and progress in the delivery of high average power ultrafast laser pulses enable a range of novel minimally invasive surgical procedures. Lung cancer is the leading cause of cancer deaths worldwide and here the resection of lung tumours by means of picosecond laser pulses is presented. This represents a potential alternative to mitigate limitations of existing surgical treatments in terms of precision and collateral thermal damage to the healthy tissue. Robust process parameters for the laser resection are demonstrated using ovine pulmonary adenocarcinoma (OPA). OPA is a naturally occurring lung cancer of sheep caused by retrovirus infection that has several features in common with some forms of human pulmonary adenocarcinoma, including a similar histological appearance, which makes it ideally suited for this study. The picosecond laser was operated at a wavelength of 515 nm to resect square cavities from fresh ex-vivo OPA samples using a range of scanning strategies. Process parameters are presented for efficient ablation of the tumour with clear margins and only minimal collateral damage to the surrounding tissue. The resection depth can be controlled precisely by means of the pulse energy. By adjusting the overlap between successive laser pulses, deliberate heat transfer to the tissue and thermal damage can be achieved. This can be beneficial for on demand haemostasis and laser coagulation. Overall, the application of ultrafast lasers for the resection of lung tumours has potential to enable significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional techniques.

Mitigation of EMU Cut Glove Hazard from Micrometeoroid and Orbital Debris Impacts on ISS Handrails

NASA Technical Reports Server (NTRS)

Ryan, Shannon; Christiansen, Eric L.; Davis, Bruce A.; Ordonez, Erick

2009-01-01

Recent cut damages sustained on crewmember gloves during extravehicular activity (ISS) onboard the International Space Station (ISS) have been caused by contact with sharp edges or a pinch point according to analysis of the damages. One potential source are protruding sharp edged crater lips from micrometeoroid and orbital debris (MMOD) impacts on metallic handrails along EVA translation paths. A number of hypervelocity impact tests were performed on ISS handrails, and found that mm-sized projectiles were capable of inducing crater lip heights two orders of magnitude above the minimum value for glove abrasion concerns. Two techniques were evaluated for mitigating the cut glove hazard of MMOD impacts on ISS handrails: flexible overwraps which act to limit contact between crewmember gloves and impact sites, and; alternate materials which form less hazardous impact crater profiles. In parallel with redesign efforts to increase the cut resilience of EMU gloves, the modifications to ISS handrails evaluated in this study provide the means to significantly reduce cut glove risk from MMOD impact craters

Operational challenges to community participation in post-disaster damage assessments: observations from Fiji.

PubMed

Méheux, Kirstie; Dominey-Howes, Dale; Lloyd, Kate

2010-10-01

Community participation is becoming increasingly popular within the field of disaster management. International disaster policies, frameworks and charters embrace the notion that communities should play an active role in initiatives to identify vulnerabilities and risks and to mitigate those dangers, and, in the event of a disaster, that they should play a proactive part in response and recovery (see, for example, UNISDR, 1994; The Sphere Project, 2004; United Nations, 2005). A number of studies have investigated the participation of communities in disaster preparedness and mitigation efforts (see, for instance, Scott-Villiers, 2000; Andharia, 2002; Godschalk, Brody and Burby, 2003), There is, however, limited reflection on the challenges to ensuring participation in the operational context of disaster response. This paper draws on a study of the policy and practice of participatory damage assessment in Fiji to identify and discuss the barriers to formal implementation of community participation in a post-disaster context. © 2010 The Author(s). Journal compilation © Overseas Development Institute, 2010.

Assessment of Stone Columns as a Mitigation Technique of Liquefaction-Induced Effects during Italian Earthquakes (May 2012)

PubMed Central

Forcellini, Davide; Tarantino, Angelo Marcello

2014-01-01

Soil liquefaction has been observed worldwide during recent major earthquakes with induced effects responsible for much of the damage, disruption of function, and considerable replacement expenses for structures. The phenomenon has not been documented in recent time with such damage in Italian context before the recent Emilia-Romagna Earthquake (May 2012). The main lateral spreading and vertical deformations affected the stability of many buildings and impacted social life inducing valuable lessons on liquefaction risk assessment and remediation. This paper aims first of all to reproduce soil response to liquefaction-induced lateral effects and thus to evaluate stone column mitigation technique effectiveness by gradually increasing the extension of remediation, in order to achieve a satisfactory lower level of permanent deformations. The study is based on the use of a FE computational interface able to analyse the earthquake-induced three-dimensional pore pressure generation adopting one of the most credited nonlinear theories in order to assess realistically the displacements connected to lateral spreading. PMID:24592148

Assessment of stone columns as a mitigation technique of liquefaction-induced effects during Italian earthquakes (May 2012).

PubMed

Forcellini, Davide; Tarantino, Angelo Marcello

2014-01-01

Soil liquefaction has been observed worldwide during recent major earthquakes with induced effects responsible for much of the damage, disruption of function, and considerable replacement expenses for structures. The phenomenon has not been documented in recent time with such damage in Italian context before the recent Emilia-Romagna Earthquake (May 2012). The main lateral spreading and vertical deformations affected the stability of many buildings and impacted social life inducing valuable lessons on liquefaction risk assessment and remediation. This paper aims first of all to reproduce soil response to liquefaction-induced lateral effects and thus to evaluate stone column mitigation technique effectiveness by gradually increasing the extension of remediation, in order to achieve a satisfactory lower level of permanent deformations. The study is based on the use of a FE computational interface able to analyse the earthquake-induced three-dimensional pore pressure generation adopting one of the most credited nonlinear theories in order to assess realistically the displacements connected to lateral spreading.

Mitigating Undesignated Trail Use: The Efficacy of Messaging and Direct Site Management Actions in an Urban-Proximate Open Space Context.

PubMed

Schwartz, F; Taff, B D; Lawhon, B; VanderWoude, D

2018-05-08

The use and creation of undesignated recreational trails can lead to erosion, vegetation damage, unsafe trail conditions, and impacts to local wildlife. The mitigation of undesignated trail use is typically addressed indirectly through minimum-impact visitor education programs such as Leave No Trace, or directly through closures or sanctions. In this study, researchers collaborated with City of Boulder, Colorado Open Space and Mountain Parks (OSMP) staff to develop a quasi-experimental field study that examined the effectiveness of indirect (messaging) and direct (barriers) management approaches to mitigating undesignated trail use. The study applied a Theory of Planned Behavior framework, utilized Leave No Trace messaging, and employed a method to pair survey and direct observation data. A total of 2232 visitor parties were observed, and 147 surveys were collected. The combined direct (barrier) and indirect (messaging) intervention was the most effective at mitigating undesignated trail use. Implications for management and future research are discussed.

An Innovative Solution to NASA's NEO Impact Threat Mitigation Grand Challenge and Flight Validation Mission Architecture Development

NASA Technical Reports Server (NTRS)

Wie, Bong; Barbee, Brent W.

2015-01-01

This paper presents the results of a NASA Innovative Advanced Concept (NIAC) Phase 2 study entitled "An Innovative Solution to NASA's Near-Earth Object (NEO) Impact Threat Mitigation Grand Challenge and Flight Validation Mission Architecture Development." This NIAC Phase 2 study was conducted at the Asteroid Deflection Research Center (ADRC) of Iowa State University in 2012-2014. The study objective was to develop an innovative yet practically implementable mitigation strategy for the most probable impact threat of an asteroid or comet with short warning time (< 5 years). The mitigation strategy described in this paper is intended to optimally reduce the severity and catastrophic damage of the NEO impact event, especially when we don't have sufficient warning times for non-disruptive deflection of a hazardous NEO. This paper provides an executive summary of the NIAC Phase 2 study results. Detailed technical descriptions of the study results are provided in a separate final technical report, which can be downloaded from the ADRC website (www.adrc.iastate.edu).

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure.

PubMed

Mordecai, Yaniv; Dori, Dov

2017-07-17

The cyber-physical gap (CPG) is the difference between the 'real' state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is inevitable at some degree in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach to capturing, explaining, and mitigating the CPG. CPGAME enhances the systems engineer's ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions and actions. We demonstrate CPGAME by applying it for modeling and analysis of the 1979 Three Miles Island 2 nuclear accident, and show how its meltdown could be mitigated. We use ISO-19450:2015-Object Process Methodology as our conceptual modeling framework.

Uncertainty as Impetus for Climate Mitigation

NASA Astrophysics Data System (ADS)

Lewandowsky, S.; Oreskes, N.; Risbey, J.

2015-12-01

For decades, the scientific community has called for actions to be taken to mitigate the adverse consequences of climate change. To date, those calls have found little substantial traction, and politicians and the general public are instead engaged in a debate about the causes and effects of climate change that bears little resemblance to the state of scientific knowledge. Uncertainty plays a pivotal role in that public debate, and arguments against mitigation are frequently couched in terms of uncertainty. We show that the rhetorical uses of scientific uncertainty in public debate by some actors (often with vested interests or political agendas) contrast with the mathematical result that greater uncertainty about the extent of warming is virtually always associated with an increased risk: The expected damage costs increase as a function of uncertainty about future warming. We suggest ways in which the actual implications of scientific uncertainty can be better communicated and how scientific uncertainty should be understood as an impetus, rather than a barrier, for climate mitigation.

ISU Team Project: An Integral View on Space Debris Mitigation and Removal

NASA Astrophysics Data System (ADS)

Maier, Philipp; Ricote Navarro, Carmon; Jehn, Rudiger; Gini, Andrea; Faure, Pauline; Adriaensen, Maarten; Datta, Iman; Hilbich, Daniel; Jacimovic, Aleksandar; Jacques, Lionel; Penent, Guilhem; Sinn, Thomas; Shioi, Hiroaki

2013-08-01

The issue of space debris poses challenges not only in technical, but also legal, political and economic dimensions. A sustainable solution needs to take into account all of them. This paper investigates such a potential solution in a multidisciplinary approach. To this end, it addresses the effectiveness of the existing debris mitigation guidelines, and identifies technical improvements for mitigation. It continues examining technical concepts for debris removal and performing proper cost-benefit trade-offs. The results of new simulations to assess the damage cost caused by space debris are presented. Based on these findings, an organizational framework and political recommendations are developed which will enable a sustainable use of space starting in 2020. The findings are compiled into a roadmap, which outlines 1) a path to the full adherence to debris mitigation guidelines and 2) the removal of ten large pieces of debris per year by a dedicated international organization, including expected expenditures necessary for its implementation.

Wind Turbine Load Mitigation based on Multivariable Robust Control and Blade Root Sensors

NASA Astrophysics Data System (ADS)

Díaz de Corcuera, A.; Pujana-Arrese, A.; Ezquerra, J. M.; Segurola, E.; Landaluze, J.

2014-12-01

This paper presents two H∞ multivariable robust controllers based on blade root sensors' information for individual pitch angle control. The wind turbine of 5 MW defined in the Upwind European project is the reference non-linear model used in this research work, which has been modelled in the GH Bladed 4.0 software package. The main objective of these controllers is load mitigation in different components of wind turbines during power production in the above rated control zone. The first proposed multi-input multi-output (MIMO) individual pitch H" controller mitigates the wind effect on the tower side-to-side acceleration and reduces the asymmetrical loads which appear in the rotor due to its misalignment. The second individual pitch H" multivariable controller mitigates the loads on the three blades reducing the wind effect on the bending flapwise and edgewise momentums in the blades. The designed H" controllers have been validated in GH Bladed and an exhaustive analysis has been carried out to calculate fatigue load reduction on wind turbine components, as well as to analyze load mitigation in some extreme cases.

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin

PubMed Central

Moruno Manchon, Jose Felix; Uzor, Ndidi-Ese; Kesler, Shelli R.; Wefel, Jeffrey S.; Townley, Debra M.; Nagaraja, Archana Sidalaghatta; Pradeep, Sunila; Mangala, Lingegowda S.; Sood, Anil K.; Tsvetkov, Andrey S.

2016-01-01

Doxorubicin, a commonly used chemotherapy agent, induces severe cardio- and neurotoxicity. Molecular mechanisms of cardiotoxicity have been extensively studied, but mechanisms by which doxorubicin exhibits its neurotoxic properties remain unclear. Here, we show that doxorubicin impairs neuronal autophagy, leading to the accumulation of an autophagy substrate p62. Neurons treated with doxorubicin contained autophagosomes, damaged mitochondria, and lipid droplets. The brains from mice treated with pegylated liposomal doxorubicin exhibited autophagosomes, often with mitochondria, lipofuscin, and lipid droplets. Interestingly, lysosomes were less acidic in doxorubicin-treated neurons. Overexpression of the transcription factor EB (TFEB), which controls the autophagy-lysosome axis, increased survival of doxorubicin-treated neurons. 2-Hydroxypropyl-β-cyclodextrin (HPβCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes. Taken together, substantial changes induced by doxorubicin contribute to neurotoxicity, cognitive disturbances in cancer patients and survivors, and accelerated brain aging. The TFEB pathway might be a new approach for mitigating damage of neuronal autophagy caused by doxorubicin. PMID:27992857

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin.

PubMed

Moruno-Manchon, Jose Felix; Uzor, Ndidi-Ese; Kesler, Shelli R; Wefel, Jeffrey S; Townley, Debra M; Nagaraja, Archana Sidalaghatta; Pradeep, Sunila; Mangala, Lingegowda S; Sood, Anil K; Tsvetkov, Andrey S

2016-12-16

Doxorubicin, a commonly used chemotherapy agent, induces severe cardio- and neurotoxicity. Molecular mechanisms of cardiotoxicity have been extensively studied, but mechanisms by which doxorubicin exhibits its neurotoxic properties remain unclear. Here, we show that doxorubicin impairs neuronal autophagy, leading to the accumulation of an autophagy substrate p62. Neurons treated with doxorubicin contained autophagosomes, damaged mitochondria, and lipid droplets. The brains from mice treated with pegylated liposomal doxorubicin exhibited autophagosomes, often with mitochondria, lipofuscin, and lipid droplets. Interestingly, lysosomes were less acidic in doxorubicin-treated neurons. Overexpression of the transcription factor EB (TFEB), which controls the autophagy-lysosome axis, increased survival of doxorubicin-treated neurons. 2-Hydroxypropyl-β-cyclodextrin (HPβCD), an activator of TFEB, also promoted neuronal survival, decreased the levels of p62, and lowered the pH in lysosomes. Taken together, substantial changes induced by doxorubicin contribute to neurotoxicity, cognitive disturbances in cancer patients and survivors, and accelerated brain aging. The TFEB pathway might be a new approach for mitigating damage of neuronal autophagy caused by doxorubicin.

Damage-reducing measures to manage flood risks in a changing climate

NASA Astrophysics Data System (ADS)

Kreibich, Heidi; Bubeck, Philip; Van Vliet, Mathijs; De Moel, Hans

2014-05-01

Damage due to floods has increased during the last few decades, and further increases are expected in several regions due to climate change and a growing vulnerability. To address the projected increase in flood risk, a combination of structural and non-structural flood risk mitigation measures is considered as a promising adaptation strategy. Such a combination takes into account that flood defence systems may fail, and prepare for unexpected crisis situations via land-use planning, building construction, evacuation and disaster response. Non-structural flood risk mitigation measures like shielding with water shutters or sand bags, building fortification or safeguarding of hazardous substances are often voluntary: they demand self-dependent action by the population at risk (Bubeck et al. 2012; 2013). It is believed that these measures are especially effective in areas with frequent flood events and low flood water levels, but some types of measures showed a significant damage-reducing effect also during extreme flood events, such as the Elbe River flood in August 2002 in Germany (Kreibich et al. 2005; 2011). Despite the growing importance of damage-reducing measures, information is still scarce about factors that motivate people to undertake such measures, the state of implementation of various non-structural measures in different countries and their damage reducing effects. Thus, we collected information and undertook an international review about this topic in the framework of the Dutch KfC project "Climate proof flood risk management". The contribution will present an overview about the available information on damage-reducing measures and draw conclusions for practical flood risk management in a changing climate. References: Bubeck, P., Botzen, W. J. W., Suu, L. T. T., Aerts, J. C. J. H. (2012): Do flood risk perceptions provide useful insights for flood risk management? Findings from central Vietnam. Journal of Flood Risk Management, 5, 4, 295-302 Bubeck, P., Botzen, W. J. W., Kreibich, H., Aerts, J. C. J. H. (2013) Detailed insights into the influence of flood-coping appraisals on mitigation behaviour. Global Environmental Change. DOI:10.1016/j.gloenvcha.2013.05.009. Kreibich, H., Thieken, A. H., Petrow, T., Müller, M., Merz, B. (2005): Flood loss reduction of private households due to building precautionary measures - Lessons Learned from the Elbe flood in August 2002. NHESS, 5, 1, 117-126. Kreibich, H., Christenberger, S., Schwarze, R. (2011) Economic motivation of households to undertake private precautionary measures against floods. NHESS, 11, 2, 309-321.

Hurricane Harvey, Houston's Petrochemical Industry, and US Chemical Safety Policy: Impacts to Environmental Justice Communities

NASA Astrophysics Data System (ADS)

Goldman, G. T.; Johnson, C.; Gutierrez, A.; Declet-Barreto, J.; Berman, E.; Bergman, A.

2017-12-01

When Hurricane Harvey made landfall outside Houston, Texas, the storm's wind speeds and unprecedented precipitation caused significant damage to the region's petrochemical infrastructure. Most notably, the company Arkema's Crosby facility suffered a power failure that led to explosions and incineration of six of its peroxide tanks. Chemicals released into the air from the explosions sent 15 emergency responders to the hospital with severe respiratory conditions and led to the evacuation of hundreds of surrounding households. Other petrochemical facilities faced other damages that resulted in unsafe and acute chemical releases into the air and water. What impacts did such chemical disasters have on the surrounding communities and emergency responders during Harvey's aftermath? What steps might companies have taken to prevent such chemical releases? And what chemical safety policies might have ensured that such disaster risks were mitigated? In this talk we will report on a survey of the extent of damage to Houston's oil and gas infrastructure and related chemical releases and discuss the role of federal chemical safety policy in preventing and mitigating the potential for such risks for future storms and other extreme weather and climate events. We will also discuss how these chemical disasters created acute toxics exposures on environmental justice communities already overburdened with chronic exposures from the petrochemical industry.

Radioprotective effect of orally administered beta-d-glucan derived from Saccharomyces cerevisiae.

PubMed

Liu, Fang; Wang, Zhuanzi; Liu, Jia; Li, Wenjian

2018-04-21

The present study was to evaluate the in vivo radioprotective effect of oral administration of Saccharomyces cerevisiae-derived-beta-d-glucan (S. cerevisiae-BG) and to investigate the protective mechanism. The results demonstrated that oral pretreatment with 350 mg/kg S. cerevisiae-BG once daily for 14 consecutive days significantly increased the survival rate of mice from 6 Gy X-rays irradiation. At the 30th day after irradiation, cellularity and the percentage of hematopoietic stem/progenitor cells in bone marrow (BM) of surviving mice were increased by S. cerevisiae-BG. Further studies showed that S. cerevisiae-BG decreased BM cell DNA damage and improved BM cell cycle progress in irradiated mice. And the reactive oxygen species (ROS) levels in BM cells of irradiated mice were also decreased by S. cerevisiae-BG. These results indicated that oral S. cerevisiae-BG exhibited obviously radioprotective effect in mice and the protective effect may be attributed to the polysaccharide's hematopoiesis-modulating action and free radical scavenging property. S. cerevisiae-BG protects BM cells from radiation damage through scavenging BM cell ROS, mitigating BM cell DNA damage and improving cell cycle progress, and thus mitigated myelosuppression induced by irradiation and stimulated hematopoiesis, ultimately increased the survival of radiated mice. Copyright © 2018. Published by Elsevier B.V.

A new topology of fuel cell hybrid power source for efficient operation and high reliability

NASA Astrophysics Data System (ADS)

Bizon, Nicu

2011-03-01

This paper analyzes a new fuel cell Hybrid Power Source (HPS) topology having the feature to mitigate the current ripple of the fuel cell inverter system. In the operation of the inverter system that is grid connected or supplies AC motors in vehicle application, the current ripple normally appears at the DC port of the fuel cell HPS. Consequently, if mitigation measures are not applied, this ripple is back propagated to the fuel cell stack. Other features of the proposed fuel cell HPS are the Maximum Power Point (MPP) tracking, high reliability in operation under sharp power pulses and improved energy efficiency in high power applications. This topology uses an inverter system directly powered from the appropriate fuel cell stack and a controlled buck current source as low power source used for ripple mitigation. The low frequency ripple mitigation is based on active control. The anti-ripple current is injected in HPS output node and this has the LF power spectrum almost the same with the inverter ripple. Consequently, the fuel cell current ripple is mitigated by the designed active control. The ripple mitigation performances are evaluated by indicators that are defined to measure the mitigation ratio of the low frequency harmonics. In this paper it is shown that good performances are obtained by using the hysteretic current control, but better if a dedicated nonlinear controller is used. Two ways to design the nonlinear control law are proposed. First is based on simulation trials that help to draw the characteristic of ripple mitigation ratio vs. fuel cell current ripple. The second is based on Fuzzy Logic Controller (FLC). The ripple factor is up to 1% in both cases.

Fast Acting Eddy Current Driven Valve for Massive Gas Injection on ITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyttle, Mark S; Baylor, Larry R; Carmichael, Justin R

2015-01-01

Tokamak plasma disruptions present a significant challenge to ITER as they can result in intense heat flux, large forces from halo and eddy currents, and potential first-wall damage from the generation of multi-MeV runaway electrons. Massive gas injection (MGI) of high Z material using fast acting valves is being explored on existing tokamaks and is planned for ITER as a method to evenly distribute the thermal load of the plasma to prevent melting, control the rate of the current decay to minimize mechanical loads, and to suppress the generation of runaway electrons. A fast acting valve and accompanying power supplymore » have been designed and first test articles produced to meet the requirements for a disruption mitigation system on ITER. The test valve incorporates a flyer plate actuator similar to designs deployed on TEXTOR, ASDEX upgrade, and JET [1 3] of a size useful for ITER with special considerations to mitigate the high mechanical forces developed during actuation due to high background magnetic fields. The valve includes a tip design and all-metal valve stem sealing for compatibility with tritium and high neutron and gamma fluxes.« less

Liquefaction-induced lateral spreading in Oceano, California, during the 2003 San Simeon Earthquake

USGS Publications Warehouse

Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.; Di Alessandro, Carola; Boatwright, John; Tinsley, John C.; Sell, Russell W.; Rosenberg, Lewis I.

2004-01-01

The December 22, 2003, San Simeon, California, (M6.5) earthquake caused damage to houses, road surfaces, and underground utilities in Oceano, California. The community of Oceano is approximately 50 miles (80 km) from the earthquake epicenter. Damage at this distance from a M6.5 earthquake is unusual. To understand the causes of this damage, the U.S. Geological Survey conducted extensive subsurface exploration and monitoring of aftershocks in the months after the earthquake. The investigation included 37 seismic cone penetration tests, 5 soil borings, and aftershock monitoring from January 28 to March 7, 2004. The USGS investigation identified two earthquake hazards in Oceano that explain the San Simeon earthquake damage?site amplification and liquefaction. Site amplification is a phenomenon observed in many earthquakes where the strength of the shaking increases abnormally in areas where the seismic-wave velocity of shallow geologic layers is low. As a result, earthquake shaking is felt more strongly than in surrounding areas without similar geologic conditions. Site amplification in Oceano is indicated by the physical properties of the geologic layers beneath Oceano and was confirmed by monitoring aftershocks. Liquefaction, which is also commonly observed during earthquakes, is a phenomenon where saturated sands lose their strength during an earthquake and become fluid-like and mobile. As a result, the ground may undergo large permanent displacements that can damage underground utilities and well-built surface structures. The type of displacement of major concern associated with liquefaction is lateral spreading because it involves displacement of large blocks of ground down gentle slopes or towards stream channels. The USGS investigation indicates that the shallow geologic units beneath Oceano are very susceptible to liquefaction. They include young sand dunes and clean sandy artificial fill that was used to bury and convert marshes into developable lots. Most of the 2003 damage was caused by lateral spreading in two separate areas, one near Norswing Drive and the other near Juanita Avenue. The areas coincided with areas with the highest liquefaction potential found in Oceano. Areas with site amplification conditions similar to those in Oceano are particularly vulnerable to earthquakes. Site amplification may cause shaking from distant earthquakes, which normally would not cause damage, to increase locally to damaging levels. The vulnerability in Oceano is compounded by the widespread distribution of highly liquefiable soils that will reliquefy when ground shaking is amplified as it was during the San Simeon earthquake. The experience in Oceano can be expected to repeat because the region has many active faults capable of generating large earthquakes. In addition, liquefaction and lateral spreading will be more extensive for moderate-size earthquakes that are closer to Oceano than was the 2003 San Simeon earthquake. Site amplification and liquefaction can be mitigated. Shaking is typically mitigated in California by adopting and enforcing up-to-date building codes. Although not a guarantee of safety, application of these codes ensures that the best practice is used in construction. Building codes, however, do not always require the upgrading of older structures to new code requirements. Consequently, many older structures may not be as resistant to earthquake shaking as new ones. For older structures, retrofitting is required to bring them up to code. Seismic provisions in codes also generally do not apply to nonstructural elements such as drywall, heating systems, and shelving. Frequently, nonstructural damage dominates the earthquake loss. Mitigation of potential liquefaction in Oceano presently is voluntary for existing buildings, but required by San Luis Obispo County for new construction. Multiple mitigation procedures are available to individual property owners. These procedures typically involve either

44 CFR 206.226 - Restoration of damaged facilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... accordance with § 206.221(e)(3)), sewer services, wastewater treatment, communications, emergency medical... to project approval or be a legal Federal or State requirement applicable to the type of restoration... applicable standards. The cost of any requirements for hazard mitigation placed on restoration projects by...

44 CFR 206.226 - Restoration of damaged facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... accordance with § 206.221(e)(3)), sewer services, wastewater treatment, communications, emergency medical... to project approval or be a legal Federal or State requirement applicable to the type of restoration... applicable standards. The cost of any requirements for hazard mitigation placed on restoration projects by...

44 CFR 206.226 - Restoration of damaged facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... accordance with § 206.221(e)(3)), sewer services, wastewater treatment, communications, emergency medical... to project approval or be a legal Federal or State requirement applicable to the type of restoration... applicable standards. The cost of any requirements for hazard mitigation placed on restoration projects by...

Repair of rutting caused by studded tires : literature review.

DOT National Transportation Integrated Search

1995-07-01

Rutting caused by studded tire wear has become a major issue in Oregon because of the impact on the infrastructure and the increase in driving hazards. It is estimated that the cost to mitigate the damage from studded tire use in 1993 alone is $42 mi...

78 FR 75574 - Agency Information Collection Activities: Submission for OMB Review; Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... assist the community to understand the National Flood Insurance Program's (NFIP's) requirements, and implement effective flood loss reductions measures. Communities can achieve cost savings through flood mitigation actions by way of insurance premium discounts and reduced property damage. Affected Public: State...

Research and Evaluations of the Health Aspects of Disasters, Part II: The Disaster Health Conceptual Framework Revisited.

PubMed

Birnbaum, Marvin L; Daily, Elaine K; O'Rourke, Ann P; Loretti, Alessandro

2015-10-01

A Conceptual Framework upon which the study of disasters can be organized is essential for understanding the epidemiology of disasters, as well as the interventions/responses undertaken. Application of the structure provided by the Conceptual Framework should facilitate the development of the science of Disaster Health. This Framework is based on deconstructions of the commonly used Disaster Management Cycle. The Conceptual Framework incorporates the steps that occur as a hazard progresses to a disaster. It describes an event that results from the changes in the release of energy from a hazard that may cause Structural Damages that in turn, may result in Functional Damages (decreases in levels of function) that produce needs (goods and services required). These needs can be met by the goods and services that are available during normal, day-to-day operations of the community, or the resources that are contained within the community's Response Capacity (ie, an Emergency), or by goods and services provided from outside of the affected area (outside response capacities). Whenever the Local Response Capacity is unable to meet the needs, and the Response Capacities from areas outside of the affected community are required, a disaster occurs. All responses, whether in the Relief or Recovery phases of a disaster, are interventions that use the goods, services, and resources contained in the Response Capacity (local or outside). Responses may be directed at preventing/mitigating further deterioration in levels of functions (damage control, deaths, injuries, diseases, morbidity, and secondary events) in the affected population and filling the gaps in available services created by Structural Damages (compromise in available goods, services, and/or resources; ie, Relief Responses), or may be directed toward returning the affected community and its components to the pre-event functional state (ie, Recovery Responses). Hazard Mitigation includes interventions designed to decrease the likelihood that a hazard will cause an event, and should an event occur, that the amount of energy released will be reduced. Capacity Building consists of all interventions undertaken before an event occurs in order to increase the resilience of the community to an event related to a hazard that exists in an area-at-risk. Resilience is the combination of the Absorbing, Buffering, and Response Capacities of a community-at-risk, and is enhanced through Capacity-Building efforts. A disaster constitutes a failure of resilience.

Evaluating Environment, Erosion and Sedimentation Aspects in Coastal Area to Determine Priority Handling (A Case Study in Jepara Regency, northern Central Java, Indonesia)

NASA Astrophysics Data System (ADS)

Wahyudi, S. I.; Adi, H. P.

2018-04-01

Many areas of the northern coastal in Central Java, Indonesia, have been suffering from damage. One of the areas is Jepara, which has been experiencing this kind of damage for 7.6 kilometres from total 72 kilometres long beach. All damages are mostly caused by coastal erosion, sedimentation, environment and tidal flooding. Several efforts have been done, such as replanting mangroves, building revetment and groins, but it still could not mitigated the coastal damage. The purposes of this study are to map the coastal damages, to analyze handling priority and to determine coastal protection model. The method used are by identifying and plotting the coastal damage on the map, assessing score of each variable, and determining the handling priority and suitable coastal protection model. There are five levels of coastal damage used in this study, namely as light damage, medium, heavy, very heavy, and extremely heavy. Based on the priority assessment of coastal damage, it needs to be followed up by designing in detail and implementing through soft structure for example mangrove, sand nourishes and hard structure, such as breakwater, groins and revetment.

Increasing global agricultural production by reducing ozone damages via methane emission controls and ozone-resistant cultivar selection

PubMed Central

Avnery, Shiri; Mauzerall, Denise L; Fiore, Arlene M

2013-01-01

Meeting the projected 50% increase in global grain demand by 2030 without further environmental degradation poses a major challenge for agricultural production. Because surface ozone (O3) has a significant negative impact on crop yields, one way to increase future production is to reduce O3-induced agricultural losses. We present two strategies whereby O3 damage to crops may be reduced. We first examine the potential benefits of an O3 mitigation strategy motivated by climate change goals: gradual emission reductions of methane (CH4), an important greenhouse gas and tropospheric O3 precursor that has not yet been targeted for O3 pollution abatement. Our second strategy focuses on adapting crops to O3 exposure by selecting cultivars with demonstrated O3 resistance. We find that the CH4 reductions considered would increase global production of soybean, maize, and wheat by 23–102 Mt in 2030 – the equivalent of a ∼2–8% increase in year 2000 production worth $3.5–15 billion worldwide (USD2000), increasing the cost effectiveness of this CH4 mitigation policy. Choosing crop varieties with O3 resistance (relative to median-sensitivity cultivars) could improve global agricultural production in 2030 by over 140 Mt, the equivalent of a 12% increase in 2000 production worth ∼$22 billion. Benefits are dominated by improvements for wheat in South Asia, where O3-induced crop losses would otherwise be severe. Combining the two strategies generates benefits that are less than fully additive, given the nature of O3 effects on crops. Our results demonstrate the significant potential to sustainably improve global agricultural production by decreasing O3-induced reductions in crop yields. PMID:23504903

Oral administration of thymoquinone mitigates the effect of cisplatin on brush border membrane enzymes, energy metabolism and antioxidant system in rat intestine.

PubMed

Shahid, Faaiza; Farooqui, Zeba; Abidi, Subuhi; Parwez, Iqbal; Khan, Farah

2017-10-01

Cisplatin (CP) is a widely used chemotherapeutic agent that elicits severe gastrointestinal toxicity. Nigella sativa, a member of family Ranunculaceae, is one of the most revered medicinal plant known for its numerous health benefits. Thymoquinone (TQ), a major bioactive component derived from the volatile oil of Nigella sativa seeds, has been shown to improve gastrointestinal functions in animal models of acute gastric/intestinal injury. In view of this, the aim of the present study was to investigate the protective effect of TQ on CP induced toxicity in rat intestine and to elucidate the mechanism underlying these effects. Rats were divided into four groups viz. control, CP, TQ and CP+TQ. Animals in CP+TQ and TQ groups were orally administered TQ (1.5mg/kg bwt) with and without a single intraperitoneal dose of CP (6mg/kg bwt) respectively. The effect of TQ was determined on CP induced alterations in the activities of brush border membrane (BBM), carbohydrate metabolism, and antioxidant defense enzymes in rat intestine. TQ administration significantly mitigated CP induced decline in the specific activities of BBM marker enzymes, both in the mucosal homogenates and in the BBM vesicles (BBMV) prepared from intestinal mucosa. Furthermore, TQ administration restored the redox and metabolic status of intestinal mucosal tissue in CP treated rats. The biochemical results were supported by histopathological findings that showed extensive damage to intestine in CP treated rats and markedly preserved intestinal histoarchitecture in CP and TQ co-treated group. The biochemical and histological data suggest a protective effect of TQ against CP-induced gastrointestinal damage. Thus, TQ may have a potential for clinical application to counteract the accompanying gastrointestinal toxicity in CP chemotherapy. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Research Contributing to Improvements in Controlling Florida's Mosquitoes and Mosquito-borne Diseases.

PubMed

Tabachnick, Walter J

2016-09-28

Research on mosquitoes and mosquito-borne diseases has contributed to improvements in providing effective, efficient, and environmentally proper mosquito control. Florida has benefitted from several research accomplishments that have increased the state's mosquito control capabilities. Research with Florida's mosquitoes has resulted in the development of ecologically sound management of mosquito impoundments on Florida's east coast. This strategy, called Rotational Impoundment Management (RIM), has improved the ability to target the delivery of pesticides and has helped to reduce non-target effects and environmental damage. Research has led to the development of an arbovirus surveillance system which includes sentinel chicken surveillance, real time use of environmental contributing factors like meteorology and hydrology to target mosquito control, as well as public health efforts to mitigate disease outbreaks to areas with risk of disease. These research driven improvements have provided substantial benefits to all of Florida. More research is needed to meet the future challenges to reduce emerging pathogens like Zika virus and the consequences of environmental changes like global climate change that are likely to influence the effects of mosquito-borne pathogens on human health and well-being.

FOD Prevention at NASA-Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

Lowrey, Nikki M.

2010-01-01

NASA-MSFC directive MID 5340.1 requires FOD prevention for all flight hardware projects, and requires all support organizations to comply. MSFC-STD-3598 implements a standard approach for FOD prevention, tailored from NAS 412. Three levels of FOD Sensitive Area are identified, adopting existing practices at other NASA facilities. Additional emphasis is given to prevention of impact damage and mitigation of facility FOD sources, especially leaks and spills. Impact Damage Susceptible (IDS) items are identified as FOD-sensitive as well as hardware vulnerable to entrapment of small items.

Silicon Dioxide Planarization: Impacts on Optical Coatings for High Energy Laser

NASA Astrophysics Data System (ADS)

Day, Travis E.

The work of this thesis is devoted to examining the impact of silicon dioxide (silica or SiO2) planarization on the optical properties and laser damage resistance of thin-film coatings. SiO2 planarization is a process to smooth out fluence limiting nodular defects within multilayer coatings for high-energy laser applications. Mitigating these defects will improve the power handling abilities and improve the lifetime of laser coatings. Presented here is a combination of work with the aim of evaluating the optical and laser damage properties of SiO2 planarization within single layers, bilayers, and multilayers. As compared to control (non-planarized) samples, a 2-3x increase in the thin-film absorption, which decreases with post-process annealing, was discovered for SiO2 planarized samples. This suggests that planarization creates oxygen-related defects which can be annealed out and little impurity implantation. Investigations of laser damage resistance were carried out at lambda = 1030nm and pulse durations of tau = 220ps and 9ps. The laser damage of single and bilayer coatings is known to be dependent on the substrate-coating interface and this is further evidenced within this thesis. This is because the effects of planarization are masked by the extrinsic laser damage processes within the single and bilayers. Slight change (< 15%) in the laser induced damage threshold (LIDT) at 220ps and 9ps was observed for planarized single and bilayers. Depending on coating design, post-process annealing was shown to increase the LIDT by 10% to 75% at 220ps and 10% to 45% at 9ps. Although the fused silica substrate surface LIDT was shown to follow the √tau pulse scaling law for pulses above 10ps, the single and bilayer coatings do not follow this pulse scaling. The divergence from the √tau pulse scaling on the coatings suggests a variation in the laser damage initiation mechanisms between 220ps and 9ps. Multilayer high-reflecting (HR) mirrors with varying planarization design were also damage tested. A 6-7 J/cm2 LIDT, with 220ps, was observed for HR coatings with SiO2 planarization layers within high electric-field areas within the coating. However, SiO2 planarization at the substrate-coating interface, where the electric-field is minimal, and control (non-planarized) was shown to have a LIDT of 63 +/- 1.2 J/cm 2 and 21.5 +/- 0.5 J/cm2 for 220ps, respectively. At 9ps, the LIDT varied less than 90% difference between the various planarization designs. The substrate-coating planarization multilayer and control coating had an equal LIDT of 9.6 +/- .3 J/cm2 at 9ps.

Overexpression of a Cytosolic Abiotic Stress Responsive Universal Stress Protein (SbUSP) Mitigates Salt and Osmotic Stress in Transgenic Tobacco Plants

PubMed Central

Udawat, Pushpika; Jha, Rajesh K.; Sinha, Dinkar; Mishra, Avinash; Jha, Bhavanath

2016-01-01

The universal stress protein (USP) is a ubiquitous protein and plays an indispensable role in plant abiotic stress tolerance. The genome of Salicornia brachiata contains two homologs of intron less SbUSP gene which encodes for salt and osmotic responsive USP. In vivo localization reveals that SbUSP is a membrane bound cytosolic protein. The role of the gene was functionally validated by developing transgenic tobacco and compared with control [wild-type (WT) and vector control (VC)] plants under different abiotic stress condition. Transgenic lines (T1) exhibited higher chlorophyll, relative water, proline, total sugar, reducing sugar, free amino acids, polyphenol contents, osmotic potential, membrane stability, and lower electrolyte leakage and lipid peroxidation (malondialdehyde content) under stress treatments than control (WT and VC) plants. Lower accumulation of H2O2 and O2− radicals was also detected in transgenic lines compared to control plants under stress conditions. Present study confers that overexpression of the SbUSP gene enhances plant growth, alleviates ROS buildup, maintains ion homeostasis and improves the physiological status of the plant under salt and osmotic stresses. Principal component analysis exhibited a statistical distinction of plant response to salinity stress, and a significant response was observed for transgenic lines under stress, which provides stress endurance to the plant. A possible signaling role is proposed that some downstream genes may get activated by abiotic stress responsive cytosolic SbUSP, which leads to the protection of cell from oxidative damages. The study unveils that ectopic expression of the gene mitigates salt or osmotic stress by scavenging ROS and modulating the physiological process of the plant. PMID:27148338

A Study on Integrated Community Based Flood Mitigation with Remote Sensing Technique in Kota Bharu, Kelantan

NASA Astrophysics Data System (ADS)

'Ainullotfi, A. A.; Ibrahim, A. L.; Masron, T.

2014-02-01

This study is conducted to establish a community based flood management system that is integrated with remote sensing technique. To understand local knowledge, the demographic of the local society is obtained by using the survey approach. The local authorities are approached first to obtain information regarding the society in the study areas such as the population, the gender and the tabulation of settlement. The information about age, religion, ethnic, occupation, years of experience facing flood in the area, are recorded to understand more on how the local knowledge emerges. Then geographic data is obtained such as rainfall data, land use, land elevation, river discharge data. This information is used to establish a hydrological model of flood in the study area. Analysis were made from the survey approach to understand the pattern of society and how they react to floods while the analysis of geographic data is used to analyse the water extent and damage done by the flood. The final result of this research is to produce a flood mitigation method with a community based framework in the state of Kelantan. With the flood mitigation that involves the community's understanding towards flood also the techniques to forecast heavy rainfall and flood occurrence using remote sensing, it is hope that it could reduce the casualties and damage that might cause to the society and infrastructures in the study area.

Overview of the Special Issue: A Multi-Model Framework to ...

EPA Pesticide Factsheets

The Climate Change Impacts and Risk Analysis (CIRA) project establishes a new multi-model framework to systematically assess the impacts, economic damages, and risks from climate change in the United States. The primary goal of this framework to estimate how climate change impacts and damages in the United States are avoided or reduced due to global greenhouse gas (GHG) emissions mitigation scenarios. Scenarios are designed to explore key uncertainties around the measurement of these changes. The modeling exercise presented in this Special Issue includes two integrated assessment models and 15 sectoral models encompassing six broad impacts sectors - water resources, electric power, infrastructure, human health, ecosystems, and forests. Three consistent emissions scenarios are used to analyze the benefits of global GHG mitigation targets: a reference and two policy scenarios, with total radiative forcing in 2100 of 10.0W/m2, 4.5W/m2, and 3.7W/m2. A range of climate sensitivities, climate models, natural variability measures, and structural uncertainties of sectoral models are examined to explore the implications of key uncertainties. This overview paper describes the motivations, goals, design, and academic contribution of the CIRA modeling exercise and briefly summarizes the subsequent papers in this Special Issue. A summary of results across impact sectors is provided showing that: GHG mitigation provides benefits to the United States that increase over

Hypervelocity impact and dynamic fragmentation of brittle materials

NASA Astrophysics Data System (ADS)

Agrawal, Vinamra; Ortega, Alejandro; Meiron, Daniel

2017-06-01

The process of hypervelocity impact and dynamic fragmentation finds application in planetary formation, satellite design for micrometeorite impact damage mitigation, armor design and crater formations. In this work, we study high velocity impact induced dynamic fragmentation processes of brittle materials. We implement ideas of Continuum Damage Mechanics (CDM) to perform fragmentation simulations on brittle materials in various geometries. The damage formulation was implemented on an existing computational framework capable of adaptive mesh refinement that operates on an Eulerian grid, thereby avoiding problems associated with grid entanglement in large deformation processes. A damage sensitive equation of state is developed for hyperelastic materials that depends on a damage variable D, the volume fraction of micro-cracks in the brittle material. The evolution of D is governed by a modified, thermodynamically consistent Grady-Kipp model that evolves damage at points of tensile eigenvalue stresses. We simulate sphere-on-sphere and sphere-on-plate impact events with ductile and brittle materials and study the resulting damage propagation. We validate our calculations with existing literature and comment on energy dissipation and optimal design. Caltech - JPL President's and Director's Fund.

Lateral damage in graphene carved by high energy focused gallium ion beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao, Zhongquan, E-mail: zhongquan.liao@ikts-md.fraunhofer.de; Dresden Center for Nanoanalysis; Institute for Materials Science and Max Bergmann Center of Biomaterials, Technische Universität Dresden, Hallwachsstraße 3, 01069 Dresden

2015-07-06

Raman mapping is performed to study the lateral damage in supported monolayer graphene carved by 30 keV focused Ga{sup +} beams. The evolution of the lateral damage is tracked based on the profiles of the intensity ratio between the D (1341 cm{sup −1}) and G (1582 cm{sup −1}) peaks (I{sub D}/I{sub G}) of the Raman spectra. The I{sub D}/I{sub G} profile clearly reveals the transition from stage 2 disorder into stage 1 disorder in graphene along the direction away from the carved area. The critical lateral damage distance spans from <1 μm up to more than 30 μm in the experiment, depending on the parametersmore » used for carving the graphene. The wide damage in the lateral direction is attributed to the deleterious tail of unfocused ions in the ion beam probe. The study raises the attention on potential sample damage during direct patterning of graphene nanostructures using the focused ion beam technique. Minimizing the total carving time is recommended to mitigate the lateral damage.« less

Diet as a factor in behavioral radiation protection following exposure to heavy particles

NASA Technical Reports Server (NTRS)

Rabin, Bernard M.; Shukitt-Hale, Barbara; Joseph, James; Todd, Paul

2005-01-01

Major risks associated with radiation exposures on deep space missions include carcinogenesis due to heavy-particle exposure of cancer-prone tissues and performance decrements due to neurological damage produced by heavy particles. Because exposure to heavy particles can cause oxidative stress, it is possible that antioxidants can be used to mitigate these risks (and possibly some health risks of microgravity). To assess the capacity of antioxidant diets to mitigate the effects of exposure to heavy particles, rats were maintained on antioxidant diets containing 2% blueberry or strawberry extract or a control diet for 8 weeks prior to exposure to 1.5 or 2.0 Gy of accelerated iron particles at Brookhaven National Laboratory. Following irradiation rats were tested on a series of behavioral tasks: amphetamine-induced taste aversion learning, operant responding and spatial learning and memory. The results indicated that the performance of the irradiated rats maintained on the antioxidant diets was, in general, significantly better than that of the control animals, although the effectiveness of the diets ameliorating the radiation-induced deterioration in performance varied as a function of both the specific diet and the specific endpoint. In addition, animals fed antioxidant diets prior to exposure showed reduced heavy particle-induced tumorigenesis one year after exposure compared to the animals fed the control diet. These results suggest that antioxidant diets have the potential to serve as part of a system designed to provide protection to astronauts against the effects of heavy particles on exploratory missions outside the magnetic field of the earth.

HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer.

PubMed

Lopes de Campos, Walter R; Chirwa, Nthato; London, Grace; Rotherham, Lia S; Morris, Lynn; Mayosi, Bongani M; Khati, Makobetsa

2014-01-01

HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated the direct and indirect effects of HIV-1 subtype C infection of cultured human cardiomyocytes and the mechanisms leading to cardiomyocytes damage; as well as a way to mitigate the damage. We evaluated a novel approach to mitigate HIVCM using a previously reported gp120 binding and HIV-1 neutralizing aptamer called UCLA1. We established a cell-based model of HIVCM by infecting human cardiomyocytes with cell-free HIV-1 or co-culturing human cardiomyocytes with HIV-infected monocyte derived macrophages (MDM). We discovered that HIV-1 subtype C unproductively (i.e. its life cycle is arrested after reverse transcription) infects cardiomyocytes. Furthermore, we found that HIV-1 initiates apoptosis of cardiomyocytes through caspase-9 activation, preferentially via the intrinsic or mitochondrial initiated pathway. CXCR4 receptor-using viruses were stronger inducers of apoptosis than CCR5 utilizing variants. Importantly, we discovered that HIV-1 induced apoptosis of cardiomyocytes was mitigated by UCLA1. However, UCLA1 had no protective effective on cardiomyocytes when apoptosis was triggered by HIV-infected MDM. When HIV-1 was treated with UCLA1 prior to infection of MDM, it failed to induce apoptosis of cardiomyocytes. These data suggest that HIV-1 causes a mitochondrial initiated apoptotic cascade, which signal through caspase-9, whereas HIV-1 infected MDM causes apoptosis predominantly via the death-receptor pathway, mediated by caspase-8. Furthermore the data suggest that UCLA1 protects cardiomyocytes from caspase-mediated apoptosis, directly by binding to HIV-1 and indirectly by preventing infection of MDM.

Social impacts of earthquakes caused by gas extraction in the Province of Groningen, The Netherlands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voort, Nick van der, E-mail: nickvdvoort@gmail.com; Vanclay, Frank, E-mail: frank.vanclay@rug.nl

Gas extraction from the Groningen gasfield in the northern Netherlands has led to localised earthquakes which are projected to become more severe. The social impacts experienced by local residents include: damage to property; declining house prices; concerns about the chance of dykes breaking; feelings of anxiety and insecurity; health issues; and anger. These social and emotional impacts are exacerbated by the increasing distrust Groningen people have towards the national government and the gas company, NAM, a partnership between Shell and ExxonMobil. The earthquakes have reopened discussions about the distribution of benefits from gas production and the extent to which benefitsmore » are retained locally. Mitigation of the impacts is attempted, but the lack of trust decreases the effectiveness of the mitigation measures. The extent of this experience of previously-unforeseen, unanticipated impacts suggests that a new social and environmental impact assessment needs to be undertaken, and a new Social Impact Management Plan (SIMP) and Impacts and Benefits Agreement (IBA) developed, so that the project can regain its legitimacy and social licence to operate. In addition to conventional gas, this paper has wider relevance for unconventional gas developments, for example shale gas extraction by hydraulic fracturing methods (fracking). - Highlights: • Gas production in Groningen has caused over 1000 earthquakes. • The induced seismicity has caused many social impacts. • Impacts include building damage, reduced house prices, fear and health issues. • Mitigation measures attempted to date are inadequate. • Distrust towards the national government and operator hinders mitigation efforts. • Gas production in Groningen has lost its social licence to operate.« less

Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.

PubMed

Steinbrenner, Holger; Bilgic, Esra; Pinto, Antonio; Engels, Melanie; Wollschläger, Lena; Döhrn, Laura; Kellermann, Kristine; Boeken, Udo; Akhyari, Payam; Lichtenberg, Artur

2016-08-01

Ischemia/reperfusion injury (IRI) contributes to morbidity and mortality after cardiovascular surgery requiring cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Multi-organ damage is associated with substantial decreases of blood selenium (Se) levels in patients undergoing cardiac surgery with CPB. We compared the influence of a dietary surplus of Se and pretreatment with ebselen, a mimic of the selenoenzyme glutathione peroxidase, on IRI-induced tissue damage and inflammation. Male Wistar rats were fed either a Se-adequate diet containing 0.3 ppm Se or supplemented with 1 ppm Se (as sodium selenite) for 5 weeks. Two other groups of Se-adequate rats received intraperitoneal injection of ebselen (30 mg/kg) or DMSO (solvent control) before surgery. The animals were connected to a heart-lung-machine and underwent 45 min of global ischemia during circulatory arrest at 16 °C, followed by re-warming and reperfusion. Selenite and ebselen suppressed IRI-induced leukocytosis and the increase in plasma levels of tissue damage markers (AST, ALT, LDH, troponin) during surgery but did not prevent the induction of proinflammatory cytokines (IL-6, TNF-α). Both Se compounds affected phosphorylation and expression of proteins related to stress response and inflammation: Ebselen increased phosphorylation of STAT3 transcription factor in the heart and decreased phosphorylation of ERK1/2 MAP kinases in the lungs. Selenite decreased ERK1/2 phosphorylation and HSP-70 expression in the heart. Pretreatment with selenite or ebselen protected against acute IRI-induced tissue damage during CPB and DHCA. Potential implications of their different actions with regard to molecular stress markers on the recovery after surgery represent promising targets for further investigation.

Kupffer Cell p38 MAPK Signaling Drives Post Burn Hepatic Damage and Pulmonary Inflammation when Alcohol Intoxication Precedes Burn Injury

PubMed Central

Chen, Michael M.; O’Halloran, Eileen B.; Ippolito, Jill A.; Kovacs, Elizabeth J.

2016-01-01

Objective Clinical and animal studies demonstrate that alcohol intoxication at the time of injury worsens post-burn outcome. The purpose of this study was to determine the role and mechanism of Kupffer cell derangement in exacerbating post-burn end organ damage in alcohol exposed mice. Design Interventional study. Setting Research Institute. Subjects Male C57BL/6 mice. Interventions Alcohol administered 30 minutes before a 15% scald burn injury. Antecedent Kupffer cell depletion with clodronate liposomes (0.5 mg/kg). p38 mitogen-activated protein kinase (MAPK) inhibition via SB203580 (10 mg/kg). Measurements and Main Results Kupffer cells were isolated 24 hours after injury and analyzed for p38 activity and IL-6 production. Intoxicated burned mice demonstrated a 2-fold (p<0.05) elevation of Kupffer cell p38 activation relative to either insult alone and this corresponded to a 43% (p<0.05) increase in IL-6 production. Depletion of Kupffer cells attenuated hepatic damage as seen by decreases of 53% (p<0.05) in serum ALT and 74% (p<0.05) in hepatic triglycerides, as well as a 77% reduction (p<0.05) in serum IL-6 levels compared to matched controls. This mitigation of hepatic damage was associated with a 54% decrease (p<0.05) in pulmonary neutrophil infiltration and reduced alveolar wall thickening by 45% (p<0.05). In vivo p38 inhibition conferred nearly identical hepatic and pulmonary protection after the combined injury as mice depleted of Kupffer cells. Conclusions Intoxication exacerbates post-burn hepatic damage through p38-dependent IL-6 production in Kupffer cells. PMID:27322363

Leveraging long sequencing reads to investigate R-gene clustering and variation in sugar beet

USDA-ARS?s Scientific Manuscript database

Host-pathogen interactions are of prime importance to modern agriculture. Plants utilize various types of resistance genes to mitigate pathogen damage. Identification of the specific gene responsible for a specific resistance can be difficult due to duplication and clustering within R-gene families....

Laboratory measurements of wave attenuation through model and live vegetation

USDA-ARS?s Scientific Manuscript database

Surge and waves generated by hurricanes and tropical storms often cause severe damage and loss of life in coastal areas. It is widely recognized that wetlands along coastal fringes reduce storm surge and waves. Yet, the potential role and primary mechanisms of wave mitigation by wetland vegetation a...

Experimental investigation of wave attenuation through model and live vegetation

USDA-ARS?s Scientific Manuscript database

Hurricanes and tropical storms often cause severe damage and loss of life in coastal areas. It is widely recognized that wetlands along coastal fringes reduce storm surge and waves. Yet, the potential role and primary mechanisms of wave mitigation by wetland vegetation are not fully understood. K...

76 FR 47219 - Pennsylvania; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... of Pennsylvania are eligible to apply for assistance under the Hazard Mitigation Grant Program. The... declaration of a major disaster for the Commonwealth of Pennsylvania (FEMA-4003-DR), dated July 13, 2011, and...''), as follows: I have determined that the damage in certain areas of the Commonwealth of Pennsylvania...

76 FR 53926 - Missouri; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... have determined that the damage in certain areas of the State of Missouri resulting from flooding... eligible to apply for assistance under the Hazard Mitigation Grant Program. (The following Catalog of... declaration of a major disaster for the State of Missouri (FEMA-4012-DR), dated August 12, 2011, and related...

76 FR 47221 - Ohio; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... determined that the damage in certain areas of the State of Ohio resulting from severe storms and flooding... apply for assistance under the Hazard Mitigation Grant Program. (The following Catalog of Federal... of a major disaster for the State of Ohio (FEMA-4002-DR), dated July 13, 2011, and related...

Identification of high-speed rail ballast flight risk factors and risk mitigation strategies - final report.

DOT National Transportation Integrated Search

2015-04-01

The phenomenon of flying ballast is well-documented in high-speed rail operations. Displaced ballast particles from the track bed : may cause damage to rolling stock as well as the track infrastructure, and wayside structures close to the right of wa...

30 CFR 250.490 - Hydrogen sulfide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... mitigate damage to property and the environment caused by H2S. You must follow the requirements of this... documentation do I need? For each individual working on the platform, either: (i) You must have documentation of... respirator; practice in donning and adjusting the assigned respirator; information on the safe briefing areas...

76 FR 43697 - BOEMRE Information Collection Activity: Coastal Impact Assistance Program (CIAP), Renewal of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... conservation, protection, or restoration of coastal areas, including wetland. (B) Mitigation of damage to fish... ID No. BOEM-2011-0001] BOEMRE Information Collection Activity: Coastal Impact Assistance Program... (ICR) to renew approval of the paperwork requirements that address the BOEMRE's Coastal Impact...

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

PubMed Central

2011-01-01

Background Flaxseed (FS) is a dietary supplement known for its antioxidant and anti-inflammatory properties. Radiation exposure of lung tissues occurs either when given therapeutically to treat intrathoracic malignancies or incidentally, such as in the case of exposure from inhaled radioisotopes released after the detonation of a radiological dispersion devise (RDD). Such exposure is associated with pulmonary inflammation, oxidative tissue damage and irreversible lung fibrosis. We previously reported that dietary FS prevents pneumonopathy in a rodent model of thoracic X-ray radiation therapy (XRT). However, flaxseed's therapeutic usefulness in mitigating radiation effects post-exposure has never been evaluated. Methods We evaluated the effects of a 10%FS or isocaloric control diet given to mice (C57/BL6) in 2 separate experiments (n = 15-25 mice/group) on 0, 2, 4, 6 weeks post a single dose 13.5 Gy thoracic XRT and compared it to an established radiation-protective diet given preventively, starting at 3 weeks prior to XRT. Lungs were evaluated four months post-XRT for blood oxygenation levels, inflammation and fibrosis. Results Irradiated mice fed a 0%FS diet had a 4-month survival rate of 40% as compared to 70-88% survival in irradiated FS-fed mouse groups. Additionally, all irradiated FS-fed mice had decreased fibrosis compared to those fed 0%FS. Lung OH-Proline content ranged from 96.5 ± 7.1 to 110.2 ± 7.7 μg/ml (Mean ± SEM) in all irradiated FS-fed mouse groups, as compared to 138 ± 10.8 μg/ml for mice on 0%FS. Concomitantly, bronchoalveolar lavage (BAL) protein and weight loss associated with radiation cachexia was significantly decreased in all FS-fed groups. Inflammatory cell influx to lungs also decreased significantly except when FS diet was delayed by 4 and 6 weeks post XRT. All FS-fed mice (irradiated or not), maintained a higher blood oxygenation level as compared to mice on 0%FS. Similarly, multiplex cytokine analysis in the BAL fluid revealed a significant decrease of specific inflammatory cytokines in FS-fed mice. Conclusions Dietary FS given post-XRT mitigates radiation effects by decreasing pulmonary fibrosis, inflammation, cytokine secretion and lung damage while enhancing mouse survival. Dietary supplementation of FS may be a useful adjuvant treatment mitigating adverse effects of radiation in individuals exposed to inhaled radioisotopes or incidental radiation. PMID:21702963

Managing for Successful Control of Naturally Occurring Asbestos During Large Scale Grading

NASA Astrophysics Data System (ADS)

Saur, R.; Harnish, D.; Cavanaugh, J.; Kendall, K.; Virdee, A.; Ludlam, D.

2012-12-01

Pacific Gas and Electric Company recently completed environmental remediation and civil grading of a 35-acre site in San Francisco Bay Area, and the project became recognized with local agencies as having excellent controls systems for naturally-occurring asbestos (NOA). The project began in 2010 and was completed in 2012, and involved excavating and grading over 100,000 tons of soil containing NOA. The work was subject to requirements by state, local and regional agencies, including an asbestos dust mitigation plan for the Bay Area Air Quality Management District. Effective control of NOA is attributed to management approaches combined with effective monitoring and state-of-the-art controls. Management Planning. The contract for construction specified NOA compliance management and controls, including having a NOA-control "czar" ultimately responsible for effective mitigation. An important element was daily pre-planning for excavation/grading that involved both the NOA mitigation experts and construction staff. Personnel Planning and Training. All construction personnel were trained before work regarding NOA hazards and mitigations. Daily tailboards with all construction personnel included discussions of the NOA controls integral to the daily work. Supervision. A NOA mitigation compliance leader was assigned to each excavation operation, responsible for continuously monitoring wind direction and work to ensure mitigation met requirements, and that disturbed areas were hydrosealed or covered. Adaptive Management - Daily and weekly debriefs occurred with those responsible for NOA controls to evaluate effectiveness, and identify improvements needed. If a monitoring result exceeded the project trigger level, work shut down and a root-cause analysis was performed to determine appropriate corrective actions. Deviations of results from background were researched as to cause, and any adjustments identified. Nearby non-project activities were monitored, as they occasionally caused trigger level exceedences in perimeter monitors, including from off-site vehicles, nearby construction, and mechanical vegetation management (e.g. weed whacking). Regulatory and Owner Oversight. Monitoring results were reported daily to agencies, agencies made frequent inspections, and owner's independent compliance representatives observed the NOA mitigation and provided real-time feedback to the construction team. NOA Controls. NOA emissions were controlled site-wide and for each work activity. Site systems included misting, water trucks on roads, temporary covers and soil sealants. Work activity controls for excavation/grading included both source and perimeter controls. Water application technologies specially designed for NOA fiber mitigation, and not just dust mitigation, were effective without adding excessive water to work areas. These activities collectively created a management structure that facilitated successful implementation of NOA control technologies.

Estimation of vulnerability functions based on a global earthquake damage database

NASA Astrophysics Data System (ADS)

Spence, R. J. S.; Coburn, A. W.; Ruffle, S. J.

2009-04-01

Developing a better approach to the estimation of future earthquake losses, and in particular to the understanding of the inherent uncertainties in loss models, is vital to confidence in modelling potential losses in insurance or for mitigation. For most areas of the world there is currently insufficient knowledge of the current building stock for vulnerability estimates to be based on calculations of structural performance. In such areas, the most reliable basis for estimating vulnerability is performance of the building stock in past earthquakes, using damage databases, and comparison with consistent estimates of ground motion. This paper will present a new approach to the estimation of vulnerabilities using the recently launched Cambridge University Damage Database (CUEDD). CUEDD is based on data assembled by the Martin Centre at Cambridge University since 1980, complemented by other more-recently published and some unpublished data. The database assembles in a single, organised, expandable and web-accessible database, summary information on worldwide post-earthquake building damage surveys which have been carried out since the 1960's. Currently it contains data on the performance of more than 750,000 individual buildings, in 200 surveys following 40 separate earthquakes. The database includes building typologies, damage levels, location of each survey. It is mounted on a GIS mapping system and links to the USGS Shakemaps of each earthquake which enables the macroseismic intensity and other ground motion parameters to be defined for each survey and location. Fields of data for each building damage survey include: · Basic earthquake data and its sources · Details of the survey location and intensity and other ground motion observations or assignments at that location · Building and damage level classification, and tabulated damage survey results · Photos showing typical examples of damage. In future planned extensions of the database information on human casualties will also be assembled. The database also contains analytical tools enabling data from similar locations, building classes or ground motion levels to be assembled and thus vulnerability relationships derived for any chosen ground motion parameter, for a given class of building, and for particular countries or regions. The paper presents examples of vulnerability relationships for particular classes of buildings and regions of the world, together with the estimated uncertainty ranges. It will discuss the applicability of such vulnerability functions in earthquake loss assessment for insurance purposes or for earthquake risk mitigation.

Methane mitigation shows significant benefits towards achieving the 1.5 degree target.

NASA Astrophysics Data System (ADS)

Collins, W.; Webber, C.; Cox, P. M.; Huntingford, C.; Lowe, J. A.; Sitch, S.

2017-12-01

Most analyses of allowable carbon emissions to achieve the 1.5 degree target implicitly assume that the ratio of CO2 to non-CO2 greenhouse gases remains near constant, and that all radiative forcing factors have similar impacts on land and ocean carbon storage. Here we determine how plausible reductions in methane emissions will make the carbon targets more feasible. We account for the latest estimates of the methane radiative effect as well as the indirect effects of methane on ozone. We particularly address the differing effects of methane and CO2 mitigation on the land carbon storage including via reduced concentrations of surface ozone. The methodology uses an intermediate complexity climate model (IMOGEN) coupled to a land surface model (JULES) which represents the details of the terrestrial carbon cycle. The carbon emissions inputs to IMOGEN are varied to find allowable pathways consistent with the Paris 1.5 K or 2.0 K targets. The IMOGEN physical parameters are altered to represent the climate characteristics of 38 CMIP5 models (such as climate sensitivity) to provide bounds on the range of allowable CO2 emissions. We examine the effects of three different methane mitigation options that are broadly consistent with the ranges in the SSP scenarios: little mitigation, cost-optimal mitigation, and maximal mitigation. The land and ocean carbon storage increases with methane mitigation, allowing more flexibility in CO2 emission reduction. This is mostly since CO2 fertilisation is reduced less with high methane mitigation, with a small contribution from reduced plant damage with lower surface ozone levels.

Orbital Debris: A Policy Perspective

NASA Technical Reports Server (NTRS)

Johnson, Nicholas L.

2007-01-01

A viewgraph presentation describing orbital debris from a policy perspective is shown. The contents include: 1) Voyage through near-Earth Space-animation; 2) What is Orbital Debris?; 3) Orbital Debris Detectors and Damage Potential; 4) Hubble Space Telescope; 5) Mir Space Station Solar Array; 6) International Space Station; 7) Space Shuttle; 8) Satellite Explosions; 9) Satellite Collisions; 10) NASA Orbital Debris Mitigation Guidelines; 11) International Space Station Jettison Policy; 12) Controlled/Uncontrolled Satellite Reentries; 13) Return of Space Objects; 14) Orbital Debris and U.S. National Space Policy; 15) U.S Government Policy Strategy; 16) Bankruptcy of the Iridium Satellite System; 17) Inter-Agency Space Debris Coordination Committee (IADC); 18) Orbital Debris at the United Nations; 19) Chinese Anti-satellite System; 20) Future Evolution of Satellite Population; and 21) Challenge of Orbital Debris

Macrobiota - helminths as active participants and partners of the microbiota in host intestinal homeostasis.

PubMed

Gause, William C; Maizels, Rick M

2016-08-01

Important insights have recently been gained in our understanding of the intricate relationship in the intestinal milieu between the vertebrate host mucosal immune response, commensal bacteria, and helminths. Helminths are metazoan worms (macrobiota) and trigger immune responses that include potent regulatory components capable of controlling harmful inflammation, protecting barrier function and mitigating tissue damage. They can secrete a variety of products that directly affect immune regulatory function but they also have the capacity to influence the composition of microbiota, which can also then impact immune function. Conversely, changes in microbiota can affect susceptibility to helminth infection, indicating that crosstalk between these two disparate groups of endobiota can play an essential role in host intestinal immune function and homeostasis. Copyright © 2016. Published by Elsevier Ltd.

Dioxin uptake by Indian plant species.

PubMed

Pandey, J S; Kumar, R; Wate, S R

2008-08-01

Dioxins like various gaseous pollutants and aerosols can be scavenged by appropriate vegetative greenbelts. Based on their stomatal properties and the models for contaminant uptake, uptake of dioxin (2,3,7,8-TCDD) by three important Indian plant species, viz. Eugenia jambolana (Jamun), Azadirachta indica (Neem) and Ficus religiosa (Peepal), has been estimated. 2,3,7,8-TCDD is a contaminant with severe harmful ecological ramifications. Computations show that Ficus religiosa has highest uptake capacity. The present exercise has its utility in designing appropriate green-belts for mitigating adverse environmental and human health impacts due to dioxins. This can be an effective management option for mitigating the damages caused by dioxins.

Two-material optimization of plate armour for blast mitigation using hybrid cellular automata

NASA Astrophysics Data System (ADS)

Goetz, J.; Tan, H.; Renaud, J.; Tovar, A.

2012-08-01

With the increased use of improvised explosive devices in regions at war, the threat to military and civilian life has risen. Cabin penetration and gross acceleration are the primary threats in an explosive event. Cabin penetration crushes occupants, damaging the lower body. Acceleration causes death at high magnitudes. This investigation develops a process of designing armour that simultaneously mitigates cabin penetration and acceleration. The hybrid cellular automaton (HCA) method of topology optimization has proven efficient and robust in problems involving large, plastic deformations such as crash impact. Here HCA is extended to the design of armour under blast loading. The ability to distribute two metallic phases, as opposed to one material and void, is also added. The blast wave energy transforms on impact into internal energy (IE) inside the solid medium. Maximum attenuation occurs with maximized IE. The resulting structures show HCA's potential for designing blast mitigating armour structures.

The cost of power outages in the business and public sectors in Israel: Revealed preference vs. subjective evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beenstock, M.; Goldin, E.; Haitovsky, Y.

1997-05-01

The economic cost of power outages is a central parameter in the cost-benefit analysis of electric power reliability and the design of electric power systems. The authors present a new methodology for estimating the cost of power outages in the business and public sections and illustrate with data for Israel. The methodology is based on the principle of revealed preference, the cost of an outage may be inferred from the actions taken by consumers to mitigate losses induced by unsupplied electricity. If outages impose costs on businesses, managers are likely to invest in back-up power to mitigate the losses thatmore » are incurred when electricity is not supplied. Investment in back-up generators may then be used to impute the mitigated and unmitigated damage from outages. 12 refs., 3 figs., 7 tabs.« less

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure

PubMed Central

2017-01-01

The cyber-physical gap (CPG) is the difference between the ‘real’ state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is inevitable at some degree in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach to capturing, explaining, and mitigating the CPG. CPGAME enhances the systems engineer’s ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions and actions. We demonstrate CPGAME by applying it for modeling and analysis of the 1979 Three Miles Island 2 nuclear accident, and show how its meltdown could be mitigated. We use ISO-19450:2015—Object Process Methodology as our conceptual modeling framework. PMID:28714910

Repetitive flood victims and acceptance of FEMA mitigation offers: an analysis with community-system policy implications.

PubMed

Kick, Edward L; Fraser, James C; Fulkerson, Gregory M; McKinney, Laura A; De Vries, Daniel H

2011-07-01

Of all natural disasters, flooding causes the greatest amount of economic and social damage. The United States' Federal Emergency Management Agency (FEMA) uses a number of hazard mitigation grant programmes for flood victims, including mitigation offers to relocate permanently repetitive flood loss victims. This study examines factors that help to explain the degree of difficulty repetitive flood loss victims experience when they make decisions about relocating permanently after multiple flood losses. Data are drawn from interviews with FEMA officials and a survey of flood victims from eight repetitive flooding sites. The qualitative and quantitative results show the importance of rational choices by flood victims in their mitigation decisions, as they relate to financial variables, perceptions of future risk, attachments to home and community, and the relationships between repetitive flood loss victims and the local flood management officials who help them. The results offer evidence to suggest the value of a more community-system approach to FEMA relocation practices. © 2011 The Author(s). Disasters © Overseas Development Institute, 2011.

Stress wave propagation and mitigation in two polymeric foams

NASA Astrophysics Data System (ADS)

Pradel, Pierre; Malaise, Frederic; Cadilhon, Baptiste; Quessada, Jean-Hugues; de Resseguier, Thibaut; Delhomme, Catherine; Le Blanc, Gael

2017-06-01

Polymeric foams are widely used in industry for thermal insulation or shock mitigation. This paper investigates the ability of a syntactic epoxy foam and an expanded polyurethane foam to mitigate intense (several GPa) and short duration (<10-6 s) stress pulses. Plate impact and electron beam irradiation experiments have been conducted to study the dynamic mechanical responses of both foams. Interferometer Doppler Laser method is used to record the target rear surface velocity. A two-wave structure associated with the propagation of an elastic precursor followed by the compaction of the pores has been observed. The compaction stress level deduced from the velocity measurement is a good indicator of mitigation capability of the foams. Quasi-static tests and dynamic soft recovery experiments have also been performed to determine the compaction mechanisms. In the polyurethane foam, the pores are closed by elastic buckling of the matrix and damage of the structure. In the epoxy foam, the compaction is due to the crushing of glass microspheres. Two porous material models successfully represent the macroscopic response of these polymeric foams.

State and local response to damaging land subsidence in United States urban areas

USGS Publications Warehouse

Holzer, T.L.

1989-01-01

Land subsidence caused by man-induced depressuring of underground reservoirs has occurred in at least nine urban areas in the United States. Significant efforts to control it have been made in three areas: Long Beach, California; Houston-Galveston, Texas; and Santa Clara Valley, California. In these areas coastal flooding and its control cost more than $300 million. Institutional changes were required in each area to ameliorate its subsidence problem. In Long Beach and Houston Galveston, efforts were made to mitigate subsidence only after significant flood damage had occurred. To arrest subsidence at Long Beach, the city lobbied for a special state law, the California Subsidence Act, that required unitization and repressuring of the Wilmington oil field. In the Houston-Galveston region, the Texas State Legislature authorized formation of the Harris-Galveston Coastal Subsidence District with authority to regulate groundwater pumping by permit. This solution, which was achieved through efforts of entities affected by subsidence, was the product of a series of compromises necessitated by political fragmentation and disjointed water planning in the region. Amelioration of subsidence in the Santa Clara Valley was a collateral benefit from the effort by water users to curtail ground-water overdraft in the valley. Importation of surface water and a tax on ground-water pumpage reduced ground-water use, thereby allowing the recovery of water level and the arresting of subsidence.

Erosion simulation of first wall beryllium armour under ITER transient heat loads

NASA Astrophysics Data System (ADS)

Bazylev, B.; Janeschitz, G.; Landman, I.; Pestchanyi, S.; Loarte, A.

2009-04-01

The beryllium is foreseen as plasma facing armour for the first wall in the ITER in form of Be-clad blanket modules in macrobrush design with brush size about 8-10 cm. In ITER significant heat loads during transient events (TE) are expected at the main chamber wall that may leads to the essential damage of the Be armour. The main mechanisms of metallic target damage remain surface melting and melt motion erosion, which determines the lifetime of the plasma facing components. Melting thresholds and melt layer depth of the Be armour under transient loads are estimated for different temperatures of the bulk Be and different shapes of transient loads. The melt motion damages of Be macrobrush armour caused by the tangential friction force and the Lorentz force are analyzed for bulk Be and different sizes of Be-brushes. The damage of FW under radiative loads arising during mitigated disruptions is numerically simulated.

Aircraft ground damage and the use of predictive models to estimate costs

NASA Astrophysics Data System (ADS)

Kromphardt, Benjamin D.

Aircraft are frequently involved in ground damage incidents, and repair costs are often accepted as part of doing business. The Flight Safety Foundation (FSF) estimates ground damage to cost operators $5-10 billion annually. Incident reports, documents from manufacturers or regulatory agencies, and other resources were examined to better understand the problem of ground damage in aviation. Major contributing factors were explained, and two versions of a computer-based model were developed to project costs and show what is possible. One objective was to determine if the models could match the FSF's estimate. Another objective was to better understand cost savings that could be realized by efforts to further mitigate the occurrence of ground incidents. Model effectiveness was limited by access to official data, and assumptions were used if data was not available. However, the models were determined to sufficiently estimate the costs of ground incidents.

Assessment of Intralaminar Progressive Damage and Failure Analysis Using an Efficient Evaluation Framework

NASA Technical Reports Server (NTRS)

Hyder, Imran; Schaefer, Joseph; Justusson, Brian; Wanthal, Steve; Leone, Frank; Rose, Cheryl

2017-01-01

Reducing the timeline for development and certification for composite structures has been a long standing objective of the aerospace industry. This timeline can be further exacerbated when attempting to integrate new fiber-reinforced composite materials due to the large number of testing required at every level of design. computational progressive damage and failure analysis (PDFA) attempts to mitigate this effect; however, new PDFA methods have been slow to be adopted in industry since material model evaluation techniques have not been fully defined. This study presents an efficient evaluation framework which uses a piecewise verification and validation (V&V) approach for PDFA methods. Specifically, the framework is applied to evaluate PDFA research codes within the context of intralaminar damage. Methods are incrementally taken through various V&V exercises specifically tailored to study PDFA intralaminar damage modeling capability. Finally, methods are evaluated against a defined set of success criteria to highlight successes and limitations.

Southern California Disasters II

NASA Technical Reports Server (NTRS)

Nicholson, Heather; Todoroff, Amber L.; LeBoeuf, Madeline A.

2015-01-01

The USDA Forest Service (USFS) has multiple programs in place which primarily utilize Landsat imagery to produce burn severity indices for aiding wildfire damage assessment and mitigation. These indices provide widely-used wildfire damage assessment tools to decision makers. When the Hyperspectral Infrared Imager (HyspIRI) is launched in 2022, the sensor's hyperspectral resolution will support new methods for assessing natural disaster impacts on ecosystems, including wildfire damage to forests. This project used simulated HyspIRI data to study three southern California fires: Aspen, French, and King. Burn severity indices were calculated from the data and the results were quantitatively compared to the comparable USFS products currently in use. The final results from this project illustrate how HyspIRI data may be used in the future to enhance assessment of fire-damaged areas and provide additional monitoring tools for decision support to the USFS and other land management agencies.

Engineering Polymer Blends for Impact Damage Mitigation

NASA Technical Reports Server (NTRS)

Gordon, Keith L.; Smith, Russell W.; Working, Dennis C.; Siochi, Emilie J.

2016-01-01

Structures containing polymers such as DuPont's Surlyn® 8940, demonstrate puncture healing when impacted by a 9 millimeter projectile traveling from speeds near 300 meters per second (1,100 feet per second) to hypervelocity impacts in the micrometeoroid velocity range of 5 kilometers per second (16,000 feet per second). Surlyn® 8940 puncture heals over a temperature range of minus 30 degrees Centigrade to plus 70 degrees Centigrade and shows potential for use in pressurized vessels subject to impact damage. However, such polymers are difficult to process and limited in applicability due to their low thermal stability, poor chemical resistance and overall poor mechanical properties. In this work, several puncture healing engineered melt formulations were developed. Moldings of melt blend formulations were impacted with a 5.56 millimeter projectile with a nominal velocity of 945 meters per second (3,100 feet per second) at about 25 degrees Centigrade, 50 degrees Centigrade and 100 degrees Centigrade, depending upon the specific blend being investigated. Self-healing tendencies were determined using surface vacuum pressure tests and tensile tests after penetration using tensile dog-bone specimens (ASTM D 638-10). For the characterization of tensile properties both pristine and impacted specimens were tested to obtain tensile modulus, yield stress and tensile strength, where possible. Experimental results demonstrate a range of new puncture healing blends which mitigate damage in the ballistic velocity regime.

Why near-miss events can decrease an individual's protective response to hurricanes.

PubMed

Dillon, Robin L; Tinsley, Catherine H; Cronin, Matthew

2011-03-01

Prior research shows that when people perceive the risk of some hazardous event to be low, they are unlikely to engage in mitigation activities for the potential hazard. We believe one factor that can lower inappropriately (from a normative perspective) people's perception of the risk of a hazard is information about prior near-miss events. A near-miss occurs when an event (such as a hurricane), which had some nontrivial probability of ending in disaster (loss of life, property damage), does not because good fortune intervenes. People appear to mistake such good fortune as an indicator of resiliency. In our first study, people with near-miss information were less likely to purchase flood insurance, and this was shown for both participants from the general population and individuals with specific interests in risk and natural disasters. In our second study, we consider a different mitigation decision, that is, to evacuate from a hurricane, and vary the level of statistical probability of hurricane damage. We still found a strong effect for near-miss information. Our research thus shows how people who have experienced a similar situation but escape damage because of chance will make decisions consistent with a perception that the situation is less risky than those without the past experience. We end by discussing the implications for risk communication. © 2010 Society for Risk Analysis.

A Study on Estimation on Flood Warning Trigger Rainfall in medium and small Stream Affected by Urban Effects

NASA Astrophysics Data System (ADS)

Youngseok, Song; Moojong, Park; JungHo, Lee; HeeSup, Lee

2013-04-01

As extreme floods occur frequently in recent years due to global climate changes, an in sudden local flooding of great volume and short duration is becoming the significant danger and loss of life and property in the Korean Peninsula as well as most parts of the world. The desire for living without hazardous damages grows these days, the city strategy to make the safer community has become an issue. Previously most of flood prevention efforts have been made for relatively large watersheds near to channel flow. However, as economical development and the expansion of city near medium and small stream, human casualty and property by flood occurs frequently. Therefore, to reduce the damage of human lives and property by flood, we develop an assessment method for flood warning trigger rainfall considering urban effect. Considering complex land use, HEC-HMS is used for rural area and SWMM is adopted for sewer networks runoff. And relationship between runoff and stream water level, HEC-RAS is accompanied with runoff results. Proposed flood warning trigger rainfall assessment method shows good agreement with gauged data and could be used for another case to mitigate damage. Acknowledgement: "This research was supported by a grant [NEMA-NH-2011-45] from the Natural Hazard Mitigation Research Group, National Emergency Management Agency of Korea." Keyword: HEC-HMS, HEC-RAS, critical precipitation, medium and small stream

Microtremor Study of Site Effect for Disaster Mitigation and Geotechnical Purpose

NASA Astrophysics Data System (ADS)

Aswad, Sabrianto; Altin Massinai, Muh.; Syamsuddin

2018-03-01

Makassar city have relatively lower earthquake vulnerability compared to other regions in Indonesia, however detailed mapping related to seismic wave amplification needs to be done in the interest of geotechnical, regional planning and disaster mitigation. It is generally known that the magnitude of the damage during the occurrence of earthquakes or tremor occur periodically is influenced by the dynamic characteristics of the building as a function of seismic wave amplification. The degree of seismic wave amplification depends on several factors, including the thickness of the sediment layer, the level of compaction and the geological age factor. The purpose of this research is to investigate seismic vulnerability in Makassar by using spectral comparison through microtremor measurement. There are several of the approaches that can be done and microtremor is the easiest and cheapest method to understand these dynamic characteristics without causing damage effects. Spectra comparison technique used was popular by Nakamura, which is comparison technique of horizontal component noise spectra and the vertical component in sediment areas (H/V spectra). Results from seismic vulnerability index (SVI) distribution maps show values ranging from 0, 14 - 158, 31. In general, the eastern part of the city of Makassar near from coastal areas is more vulnerable to damage especially earthquakes or periodic earth tremor with certain dominant frequency compared with the western part of Makassar City.

Civil Defence Pedagogies and Narratives of Democracy: Disaster Education in Germany

ERIC Educational Resources Information Center

Chadderton, Charlotte

2015-01-01

"Disaster education" is a fledgling area of study in lifelong education. Many countries educate their populations for disasters, to mitigate potential damage and loss of life, as well as contribute to national security. In this paper, which draws on interview data from the German Federal Office for Civil Defence and Disaster Assistance…

When the Happy Victimizer Says Sorry: Children's Understanding of Apology and Emotion

ERIC Educational Resources Information Center

Smith, Craig E.; Chen, Diyu; Harris, Paul L.

2010-01-01

Previous research suggests that children gradually understand the mitigating effects of apology on damage to a transgressor's reputation. However, little is known about young children's insights into the central emotional implications of apology. In two studies, children ages 4-9 heard stories about moral transgressions in which the wrongdoers…

Wildland-urban interface resident's views on risk and attribution

Treesearch

Patricia J. Cohn; Daniel R. Williams; Matthew S. Carroll

2008-01-01

Catastrophic wildfires that impact human communities have become increasingly common in recent years. To reduce the potential for damage to human communities, wildland-urban interface (WUI) residents have been encouraged to perform mitigation or fire-safing measures around their homes and communities. Yet homeowners have not wholeheartedly adopted these measures, even...

Home wreckers in search of moisture

Treesearch

Carol A. Clausen; Frederick Green

2002-01-01

Research at the Forest Products Laboratory (FPL) related to durability and disaster mitigation includes damage by decay fungi and termites and contamination by mold fungi. All these household pests are attracted to excess moisture, which can result from inadequate surface drying of condensation, leaks in pipes and foundations, poor ventila-tion, or flooding. Homeowners...

Benefits of Greenhouse Gas Mitigation on the Supply, Management, and Use of Water Resources in the United States

EPA Science Inventory

Climate change impacts on water resources in the U.S. are likely to be far-reaching and substantial, because the water sector spans many parts of the economy, from supply and demand for agriculture, industry, energy production, transportation and municipal use to damages from nat...

Development of a sweet cherry pepper line with resistance to the southern root-knot nematode Meloidogyne incognita

USDA-ARS?s Scientific Manuscript database

The southern root-knot nematode (Meloidogyne incognita) is a major pathogen of pepper (Capsicum spp.), causing significant yield losses in heavily infected plants. The N-gene confers resistance to M. incognita, and has been successfully used to mitigate nematode damage in specific pepper varieties f...

Pyraclostrobin wash-off from sugarcane leaves and aerobic dissipation in agricultural soil

USDA-ARS?s Scientific Manuscript database

In order to mitigate damage from the fungal sugarcane pathogen brown rust (Puccinia melanocephala), a Section 18 Emergency Use Label was put in place by the EPA for the application of pyraclostrobin (trade name Headline® SC; produced by BASF) on sugarcane in 2008. In order to assess the dynamics of ...

Learning to coexist with wildfire

Treesearch

M.A. Moritz; E. Batlloria; R.A. Bradstock; Jeff Stringer; Robbie Sitzlar; P.F. Hessburg; J. Leonard; S. McCaffrey; D.C. Odion; T. Schoennagel; A.D. Syphard

2014-01-01

The impacts of escalating wildfire in many regions — the lives and homes lost, the expense of suppression and the damage to ecosystem services — necessitate a more sustainable coexistence with wildfire. Climate change and continued development on fire-prone landscapes will only compound current problems. Emerging strategies for managing ecosystems and mitigating risks...

Protecting the photosynthetic performance of snap bean under free-air ozone exposure

USDA-ARS?s Scientific Manuscript database

Tropospheric ozone (O3) is a major air pollutant and causes serious injury to vegetation. To protect sensitive plants from O3 damage, several agrochemicals have been assessed, such as ethylenediurea (EDU) and kinetin (KIN). However, the mitigating abilities of EDU and KIN have not yet been compared ...

76 FR 54480 - Louisiana; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... have determined that the damage in certain areas of the State of Louisiana resulting from flooding... State of Louisiana are eligible to apply for assistance under the Hazard Mitigation Grant Program. The... declaration of a major disaster for the State of Louisiana (FEMA-4015-DR), dated August 18, 2011, and related...

76 FR 790 - Arizona; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-06

... eligible to apply for assistance under the Hazard Mitigation Grant Program. The following Catalog of... declaration of a major disaster for the State of Arizona (FEMA-1950-DR), dated December 21, 2010, and related... follows: I have determined that the damage in certain areas of the State of Arizona resulting from severe...

76 FR 24040 - North Carolina; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... apply for assistance under the Hazard Mitigation Grant Program. The following Catalog of Federal... Presidential declaration of a major disaster for the State of North Carolina (FEMA-1969-DR), dated April 19... ``Stafford Act''), as follows: I have determined that the damage in certain areas of the State of North...

75 FR 18518 - Massachusetts; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... Stafford Act for Hazard Mitigation and Other Needs Assistance will be limited to 75 percent of the total... declaration of a major disaster for the Commonwealth of Massachusetts (FEMA-1895-DR), dated March 29, 2010... follows: I have determined that the damage in certain areas of the Commonwealth of Massachusetts resulting...

76 FR 63940 - Kansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... follows: I have determined that the damage in certain areas of the State of Kansas resulting from flooding... Act for Public Assistance and Hazard Mitigation will be limited to 75 percent of the total eligible... declaration of a major disaster for the State of Kansas (FEMA-4035-DR), dated September 23, 2011, and related...

76 FR 44346 - Vermont; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

... determined that the damage in certain areas of the State of Vermont resulting from severe storms and flooding... within the State of Vermont are eligible to apply for assistance under the Hazard Mitigation Grant... declaration of a major disaster for the State of Vermont (FEMA-1995-DR), dated June 15, 2011, and related...

77 FR 37915 - Kansas; Major Disaster Declaration and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... to apply for assistance under the Hazard Mitigation Grant Program. The following Catalog of Federal... Presidential declaration of a major disaster for the State of Kansas (FEMA-4063-DR), dated May 24, 2012, and... have determined that the damage in certain areas of the State of Kansas resulting from severe storms...

76 FR 53142 - Kentucky; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... Stafford Act for Public Assistance and Hazard Mitigation will be limited to 75 percent of the total... declaration of a major disaster for the Commonwealth of Kentucky (FEMA-4008-DR), dated July 25, 2011, and...''), as follows: I have determined that the damage in certain areas of the Commonwealth of Kentucky...

75 FR 18517 - West Virginia; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... State of West Virginia are eligible to apply for assistance under the Hazard Mitigation Grant Program... declaration of a major disaster for the State of West Virginia (FEMA-1893-DR), dated March 29, 2010, and... follows: I have determined that the damage in certain areas of the State of West Virginia resulting from...

76 FR 6809 - California; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... within the State of California are eligible to apply for assistance under the Hazard Mitigation Grant... declaration of a major disaster for the State of California (FEMA-1952-DR), dated January 26, 2011, and... Act''), as follows: I have determined that the damage in certain areas of the State of California...

76 FR 44029 - Iowa; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-22

... determined that the damage in certain areas of the State of Iowa resulting from flooding beginning on May 25... eligible to apply for assistance under the Hazard Mitigation Grant Program. The following Catalog of... of a major disaster for the State of Iowa (FEMA-1998-DR), dated June 27, 2011, and related...

75 FR 52963 - Illinois; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... the damage in certain areas of the State of Illinois resulting from severe storms and flooding during... declaration of a major disaster for the State of Illinois (FEMA-1935-DR), dated August 19, 2010, and related... assistance is supplemental, any Federal funds provided under the Stafford Act for Hazard Mitigation and Other...

Melanin and the ecology of southern pine beetle associated fungi

Treesearch

Kier D. Klepzig

2006-01-01

I report here a series of initial investigations into effects of melanins on the interactions of the three primary species of fungi associated with the southern pine beetle (SPB), and into possible means for mitigating the damaging activities of the melanistic fungus, Ophiostoma minus. Growth of the SPB mutualistic fungus Entomocorticium...

76 FR 44405 - Regulation To Mitigate the Misfueling of Vehicles and Engines With Gasoline Containing Greater...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

... proposed color scheme and general design so that the two agencies' labels could work together as a... Programs AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: In two recent actions... Damage d. Addressing Non-English Speakers e. Portable Fuel Containers f. Color, Size, Shape, Font, and...

Dust Storm Feature Identification and Tracking from 4D Simulation Data

NASA Astrophysics Data System (ADS)

Yu, M.; Yang, C. P.

2016-12-01

Dust storms cause significant damage to health, property and the environment worldwide every year. To help mitigate the damage, dust forecasting models simulate and predict upcoming dust events, providing valuable information to scientists, decision makers, and the public. Normally, the model simulations are conducted in four-dimensions (i.e., latitude, longitude, elevation and time) and represent three-dimensional (3D), spatial heterogeneous features of the storm and its evolution over space and time. This research investigates and proposes an automatic multi-threshold, region-growing based identification algorithm to identify critical dust storm features, and track the evolution process of dust storm events through space and time. In addition, a spatiotemporal data model is proposed, which can support the characterization and representation of dust storm events and their dynamic patterns. Quantitative and qualitative evaluations for the algorithm are conducted to test the sensitivity, and capability of identify and track dust storm events. This study has the potential to assist a better early warning system for decision-makers and the public, thus making hazard mitigation plans more effective.

Multi-physics damage sensing in nano-engineered structural composites.

PubMed

de Villoria, Roberto Guzmán; Yamamoto, Namiko; Miravete, Antonio; Wardle, Brian L

2011-05-06

Non-destructive evaluation techniques can offer viable diagnostic and prognostic routes to mitigating failures in engineered structures such as bridges, buildings and vehicles. However, existing techniques have significant drawbacks, including poor spatial resolution and limited in situ capabilities. We report here a novel approach where structural advanced composites containing electrically conductive aligned carbon nanotubes (CNTs) are ohmically heated via simple electrical contacts, and damage is visualized via thermographic imaging. Damage, in the form of cracks and other discontinuities, usefully increases resistance to both electrical and thermal transport in these materials, which enables tomographic full-field damage assessment in many cases. Characteristics of the technique include the ability for real-time measurement of the damage state during loading, low-power operation (e.g. 15 °C rise at 1 W), and beyond state-of-the-art spatial resolution for sensing damage in composites. The enhanced thermographic technique is a novel and practical approach for in situ monitoring to ascertain structural health and to prevent structural failures in engineered structures such as aerospace and automotive vehicles and wind turbine blades, among others.

Multi-physics damage sensing in nano-engineered structural composites

NASA Astrophysics Data System (ADS)

Guzmán de Villoria, Roberto; Yamamoto, Namiko; Miravete, Antonio; Wardle, Brian L.

2011-05-01

Non-destructive evaluation techniques can offer viable diagnostic and prognostic routes to mitigating failures in engineered structures such as bridges, buildings and vehicles. However, existing techniques have significant drawbacks, including poor spatial resolution and limited in situ capabilities. We report here a novel approach where structural advanced composites containing electrically conductive aligned carbon nanotubes (CNTs) are ohmically heated via simple electrical contacts, and damage is visualized via thermographic imaging. Damage, in the form of cracks and other discontinuities, usefully increases resistance to both electrical and thermal transport in these materials, which enables tomographic full-field damage assessment in many cases. Characteristics of the technique include the ability for real-time measurement of the damage state during loading, low-power operation (e.g. 15 °C rise at 1 W), and beyond state-of-the-art spatial resolution for sensing damage in composites. The enhanced thermographic technique is a novel and practical approach for in situ monitoring to ascertain structural health and to prevent structural failures in engineered structures such as aerospace and automotive vehicles and wind turbine blades, among others.

The role of baseflow in dissolved solids delivery to streams in the Upper Colorado River Basin

NASA Astrophysics Data System (ADS)

Rumsey, C.; Miller, M. P.; Schwarz, G. E.; Susong, D.

2017-12-01

Salinity has a major effect on water users in the Colorado River Basin, estimated to cause almost $300 million per year in economic damages. The Colorado River Basin Salinity Control Program implements and manages projects to reduce salinity (dissolved solids) loads, investing millions of dollars per year in irrigation upgrades, canal projects, and other mitigation strategies. To inform and improve mitigation efforts, there is a need to better understand sources of salinity to streams and how salinity has changed over time. This study explores salinity in baseflow, or groundwater discharge to streams, to assess whether groundwater is a significant contributor of dissolved solids to streams in the Upper Colorado River Basin (UCRB). Chemical hydrograph separation was used to estimate long-term mean annual baseflow discharge and baseflow dissolved solids loads at stream gages (n=69) across the UCRB. On average, it is estimated that 89% of dissolved solids loads originate from the baseflow fraction of streamflow. Additionally, a statistical trend analysis using weighted regressions on time, discharge, and season was used to evaluate changes in baseflow dissolved solids loads in streams with data from 1987 to 2011 (n=29). About two-thirds (62%) of these streams showed statistically significant decreasing trends in baseflow dissolved solids loads. At the two most downstream sites, Green River at Green River, UT and Colorado River at Cisco, UT, baseflow dissolved solids loads decreased by a combined 780,000 metric tons, which is approximately 65% of the estimated basin-scale decrease in total dissolved solids loads in the UCRB attributed to salinity control efforts. Results indicate that groundwater discharged to streams, and therefore subsurface transport processes, play a large role in delivering dissolved solids to streams in the UCRB. Decreasing trends in baseflow dissolved solids loads suggest that salinity mitigation projects, changes in land use, and/or climate are decreasing salinity in groundwater transported to streams.

Gross morphometric reduction of rats' cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract.

PubMed

Owoeye, O; Farombi, E O; Onwuka, S K

2011-01-01

The methanolic extract of Vernonia amygdalina (M) or "bitter leaf" is known for its antioxidant activity, and antioxidants are noted to mitigate radiation damage in tissues. The aim of the present study was to observe the radioprotective effect of M on the cerebellum of gamma irradiated rats using alpha-tocopherol (TOCO) as a reference antioxidant. Forty-two male Wistar rats (n=42) weighing 200-240 g were taken for the study. The study comprised of seven groups, with each group comprising of six (n=6) rats i.e. control, M at 250, and 500 mg/kg/day, radiation only, radiation plus M at 250, and 500 mg/kg/day, and TOCO. After 14 days of treatment administered via oral gavage, rats were irradiated with a single dose of 2.0 Gy of gamma rays on the 15-th day and euthanized the next day. Rats cerebella were removed, fixed in 10% formalin saline, weighed and vernier caliper used to obtain cerebellar dimensions as follows: (i) maximum width, (ii) rostrocaudal dimension, and (iii) dorsoventral extent. Data were analyzed using ANOVA with post-test. Gamma radiation caused a statistically significant reduction of the relative weight of the rats' whole brain, relative weight of the cerebellum, the maximum width, rostrocaudal dimension, and dorsoventral extent of the cerebellum. However, pretreatment with M and TOCO significantly mitigated these effects. This study demonstrated that administration of M and TOCO before 2.0 Gy gamma irradiation reduced significantly the radiation induced gross morphometry changes in rats' cerebellum, suggesting that M may qualify for consideration as a medicinal radioprotector.

Observing storm surges from satellite altimetry

NASA Astrophysics Data System (ADS)

Han, Guoqi

2016-07-01

Storm surges can cause catastrophic damage to properties and loss of life in coastal communities. Thus it is important to enhance our capabilities of observing and forecasting storm surges for mitigating damage and loss. In this presentation we show examples of observing storm surges around the world using nadir satellite altimetry, during Hurricane Sandy, Igor, and Isaac, as well as other cyclone events. The satellite observations are evaluated against tide-gauge observations and discussed for dynamic mechanisms. We also show the potential of a new wide-swath altimetry mission, the Surface Water and Ocean Topography (SWOT), for observing storm surges.

Earth Observations taken by the Expedition 10 crew

NASA Image and Video Library

2005-01-13

ISS010-E-12917 (13 January 2005) --- One of a series of post-tsunami digital still images photographed from the International Space Station on January 13, 2005. This image, centered at 4.9 degrees north latitude and 72.9 degrees east longitude, and one of several showing the Maldives, shows the east portion of Goidhoo (also called Horsburgh) Atoll. Also visible are Goidhoo (Goidu) Island and Fehendoo (Fehendu) Island. Information is sketchy on how much damage was actually sustained in the region, but NASA scientists studying the ISS imagery say that coral reefs likely mitigated the damage level.

Climate change adaptation strategies and mitigation policies

NASA Astrophysics Data System (ADS)

García Fernández, Cristina

2015-04-01

The pace of climate change and the consequent warming of the Earth's surface is increasing vulnerability and decreasing adaptive capacity. Achieving a successful adaptation depends on the development of technology, institutional organization, financing availability and the exchange of information. Populations living in arid and semi-arid zones, low-lying coastal areas, land with water shortages or at risk of overflow or small islands are particularly vulnerable to climate change. Due to increasing population density in sensitive areas, some regions have become more vulnerable to events such as storms, floods and droughts, like the river basins and coastal plains. Human activities have fragmented and increased the vulnerability of ecosystems, which limit both, their natural adaptation and the effectiveness of the measures adopted. Adaptation means to carry out the necessary modifications for society to adapt to new climatic conditions in order to reduce their vulnerability to climate change. Adaptive capacity is the ability of a system to adjust to climate change (including climate variability and extremes) and to moderate potential damages, to take advantage of opportunities or face the consequences. Adaptation reduces the adverse impacts of climate change and enhance beneficial impacts, but will not prevent substantial cost that are produced by all damages. The performances require adaptation actions. These are defined and implemented at national, regional or local levels since many of the impacts and vulnerabilities depend on the particular economic, geographic and social circumstances of each country or region. We will present some adaptation strategies at national and local level and revise some cases of its implementation in several vulnerable areas. However, adaptation to climate change must be closely related to mitigation policies because the degree of change planned in different climatic variables is a function of the concentration levels that are achieved by greenhouse gases in the atmosphere. Mitigation and adaptation are therefore complementary actions. In the long term, climate change without mitigation measures will likely exceed the adaptive capacity of natural, managed and human systems. Early adoption of mitigation measures would break the dependence on carbon-intensive infrastructures and reduce adaptation needs to climate change. It also can save on adaptation cost. Therefore mitigation is the key objective of the global warming problem but little is being done in this field. We will present some proposals of "preventive economically efficient" policies at a global and regional level which will constitute the complement to the adaptation aspect.

International Experiences with Quantifying the Co-Benefits of Energy-Efficiency and Greenhouse-Gas Mitigation Programs and Policies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Christopher; Hasanbeigi, Ali; Price, Lynn

Improving the efficiency of energy production and consumption and switching to lower carbon energy sources can significantly decrease carbon dioxide (CO2) emissions and reduce climate change impacts. A growing body of research has found that these measures can also directly mitigate many non-climate change related human health hazards and environmental damage. Positive impacts of policies and programs that occur in addition to the intended primary policy goal are called co-benefits. Policy analysis relies on forecasting and comparing the costs of policy and program implementation and the benefits that accrue to society from implementation. GHG reduction and energy efficiency policies andmore » programs face political resistance in part because of the difficulty of quantifying their benefits. On the one hand, climate change mitigation policy benefits are often global, long-term, and subject to large uncertainties, and subsidized energy pricing can reduce the direct monetary benefits of energy efficiency policies to below their cost. On the other hand, the co-benefits that accrue from these efforts’ resultant reductions in conventional air pollution (such as improved health, agricultural productivity, reduced damage to infrastructure, and local ecosystem improvements) are generally near term, local, and more certain than climate change mitigation benefits and larger than the monetary value of energy savings. The incorporation of co-benefits into energy efficiency and climate mitigation policy and program analysis therefore might significantly increase the uptake of these policies. Faster policy uptake is especially important in developing countries because ongoing development efforts that do not consider co-benefits may lock in suboptimal technologies and infrastructure and result in high costs in future years. Over the past two decades, studies have repeatedly documented that non-climate change related benefits of energy efficiency and fuel conversion efforts, as a part of GHG mitigation strategies, can be from between 30% to over 100% of the costs of such policies and programs strategies. Policy makers around the world are increasingly interested in including both GHG and non-GHG impacts in analyses of energy efficiency and fuel switching policies and programs and a set of methodologies has matured from the efforts of early moving jurisdictions such as the European Union, the United States, and Japan.« less

Landslide databases to compare regional repair and mitigation strategies of transportation infrastructure

NASA Astrophysics Data System (ADS)

Wohlers, Annika; Damm, Bodo

2017-04-01

Regional data of the Central German Uplands are extracted from the German landslide database in order to understand the complex interactions between landslide risks and public risk awareness considering transportation infrastructure. Most information within the database is gathered by means of archive studies from inventories of emergency agencies, state, press and web archives, company and department records as well as scientific and (geo)technical literature. The information includes land use practices, repair and mitigation measures with resultant costs of the German road network as well as railroad and waterway networks. It therefore contains valuable information of historical and current landslide impacts, elements at risk and provides an overview of spatiotemporal changes in social exposure and vulnerability to landslide hazards over the last 120 years. On a regional scale the recorded infrastructure damages, and consequential repair or mitigation measures were categorized and classified, according to relevant landslide types, processes and types of infrastructure. In a further step, the data of recent landslides are compared with historical and modern repair and mitigation measures and are correlated with socioeconomic concepts. As a result, it is possible to identify some complex interactions between landslide hazard, risk perception, and damage impact, including time lags and intensity thresholds. The data reveal distinct concepts of repairing respectively mitigating landslides on different types of transportation infrastructure, which are not exclusively linked to higher construction efforts (e.g. embankments on railroads and channels), but changing levels of economic losses and risk perception as well. In addition, a shift from low cost prevention measures such as the removal of loose rock and vegetation, rock blasting, and catch barriers towards expensive mitigation measures such as catch fences, soil anchoring and rock nailing over time can be noticed. This temporal shift is associated with a higher public hazard awareness towards landslides which is at some sites linked to an apparent increase in landslide frequency and magnitude. Damm B., Klose M. (2015) The landslide database for Germany: Closing the gap at national level. Geomorphology. 249: 82-93. Klose, M., Damm, B., Terhorst, B. (2015): Landslide cost modeling for transportation infrastructures: a methodological approach. Landslides 12: 321-334. Klose M., Maurischat P., Damm B. (2016) Landslide impacts in Germany: A historical and socioeconomic perspective. Landslides. 13: 183-199.

Evaluation of the crash mitigation effect of low-speed automated emergency braking systems based on insurance claims data.

PubMed

Isaksson-Hellman, Irene; Lindman, Magdalena

2016-09-01

The aim of the present study was to evaluate the crash mitigation performance of low-speed automated emergency braking collision avoidance technologies by examining crash rates, car damage, and personal injuries. Insurance claims data were used to identify rear-end frontal collisions, the specific situations where the low-speed automated emergency braking system intervenes. We compared cars of the same model (Volvo V70) with and without the low-speed automated emergency braking system (AEB and no AEB, respectively). Distributions of spare parts required for car repair were analyzed to identify car damage, and crash severity was estimated by comparing the results with laboratory crash tests. Repair costs and occupant injuries were investigated for both the striking and the struck vehicle. Rear-end frontal collisions were reduced by 27% for cars with low-speed AEB compared to cars without the system. Those of low severity were reduced by 37%, though more severe crashes were not reduced. Accordingly, the number of injured occupants in vehicles struck by low-speed AEB cars was reduced in low-severity crashes. In offset crash configurations, the system was found to be less effective. This study adds important information about the safety performance of collision avoidance technologies, beyond the number of crashes avoided. By combining insurance claims data and information from spare parts used, the study demonstrates a mitigating effect of low-speed AEB in real-world traffic.

Spatially-explicit valuation of coastal wetlands for cyclone mitigation in Australia and China.

PubMed

Ouyang, Xiaoguang; Lee, Shing Yip; Connolly, Rod M; Kainz, Martin J

2018-02-14

Coastal wetlands are increasingly recognised for their pivotal role in mitigating the growing threats from cyclones (including hurricanes) in a changing climate. There is, however, insufficient information about the economic value of coastal wetlands for cyclone mitigation, particularly at regional scales. Analysis of data from 1990-2012 shows that the variation of cyclone frequencies is related to EI Niño strength in the Pacific Ocean adjacent to Australia, but not China. Among the cyclones hitting the two countries, there are significant relationships between the ratio of total economic damage to gross domestic production (TD/GDP) and wetland area within cyclone swaths in Australia, and wetland area plus minimum cyclone pressure despite a weak relationship in China. The TD/GDP ratio is significantly higher in China than in Australia. Despite their extensive and growing occurrence, seawalls in China appear not to play a critical role in cyclone mitigation, and cannot replace coastal wetlands, which provide other efficient ecosystem services. The economic values of coastal wetlands in Australia and China are respectively estimated at US$52.88 billion and 198.67 billion yr -1 for cyclone mitigation, albeit with large within-country geographic variation. This study highlights the urgency to integrate this value into existing valuations of coastal wetlands.

The ITER disruption mitigation trigger: developing its preliminary design

NASA Astrophysics Data System (ADS)

Pautasso, G.; de Vries, P. C.; Humphreys, D.; Lehnen, M.; Rapson, C.; Raupp, G.; Snipes, J. A.; Treutterer, W.; Vergara-Fernandez, A.; Zabeo, L.

2018-03-01

A concept for the generation of the trigger for the ITER disruption mitigation system is described in this paper. The issuing of the trigger will be the result of a complex decision process, taken by the plasma control system, or by the central interlock system, determining that the plasma is unavoidably going to disrupt—or has disrupted—and that a fast mitigated shut-down is required. Given the redundancy of the mitigation system, the plasma control system must also formulate an injection scheme and specify when and how the injectors of the mitigation system should be activated. The parameters and the conceptual algorithms required for the configuration and generation of the trigger are discussed.

Interpreting Disruption Prediction Models to Improve Plasma Control

NASA Astrophysics Data System (ADS)

Parsons, Matthew

2017-10-01

In order for the tokamak to be a feasible design for a fusion reactor, it is necessary to minimize damage to the machine caused by plasma disruptions. Accurately predicting disruptions is a critical capability for triggering any mitigative actions, and a modest amount of attention has been given to efforts that employ machine learning techniques to make these predictions. By monitoring diagnostic signals during a discharge, such predictive models look for signs that the plasma is about to disrupt. Typically these predictive models are interpreted simply to give a `yes' or `no' response as to whether a disruption is approaching. However, it is possible to extract further information from these models to indicate which input signals are more strongly correlated with the plasma approaching a disruption. If highly accurate predictive models can be developed, this information could be used in plasma control schemes to make better decisions about disruption avoidance. This work was supported by a Grant from the 2016-2017 Fulbright U.S. Student Program, administered by the Franco-American Fulbright Commission in France.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rasmussen, Lynn

The Restoring Anadromous Fish Habitat in the Lapwai Creek Watershed is a multi-phase project to enhance steelhead trout in the Lapwai Creek watershed by improving salmonid spawning and rearing habitat. Habitat is limited by extreme high runoff events, low summer flows, high water temperatures, poor instream cover, spawning gravel siltation, and sediment, nutrient and bacteria loading. Funded by the Bonneville Power Administration (BPA) as part of the Northwest Power Planning Council's Fish and Wildlife Program, the project assists in mitigating damage to steelhead runs caused by the Columbia River hydroelectric dams. The project is sponsored by the Nez Perce Soilmore » and Water Conservation District (District). Target fish species include steelhead trout (Oncorhynchus mykiss). Steelhead trout within the Snake River Basin were listed in 1997 as threatened under the Endangered Species Act. Accomplishments for the contract period December 1, 2003 through February 28, 2004 include; seven grade stabilization structures, 0.67 acres of wetland plantings, ten acres tree planting, 500 linear feet streambank erosion control, two acres grass seeding, and 120 acres weed control.« less

Enhancing radiation tolerance by controlling defect mobility and migration pathways in multicomponent single-phase alloys

DOE PAGES

Lu, Chenyang; Niu, Liangliang; Chen, Nanjun; ...

2016-12-15

A grand challenge in material science is to understand the correlation between intrinsic properties and defect dynamics. Radiation tolerant materials are in great demand for safe operation and advancement of nuclear and aerospace systems. Unlike traditional approaches that rely on microstructural and nanoscale features to mitigate radiation damage, this study demonstrates enhancement of radiation tolerance with the suppression of void formation by two orders magnitude at elevated temperatures in equiatomic single-phase concentrated solid solution alloys, and more importantly, reveals its controlling mechanism through a detailed analysis of the depth distribution of defect clusters and an atomistic computer simulation. The enhancedmore » swelling resistance is attributed to the tailored interstitial defect cluster motion in the alloys from a long-range one-dimensional mode to a short-range three-dimensional mode, which leads to enhanced point defect recombination. Finally, the results suggest design criteria for next generation radiation tolerant structural alloys.« less

Experimental and modeling approaches for food waste composting: a review.

PubMed

Li, Zhentong; Lu, Hongwei; Ren, Lixia; He, Li

2013-10-01

Composting has been used as a method to dispose food waste (FW) and recycle organic matter to improve soil structure and fertility. Considering the significance of composting in FW treatment, many researchers have paid their attention on how to improve FW composting efficiency, reduce operating cost, and mitigate the associated environmental damage. This review focuses on the overall studies of FW composting, not only various parameters significantly affecting the processes and final results, but also a number of simulation approaches that are greatly instrumental in well understanding the process mechanism and/or results prediction. Implications of many key ingredients on FW composting performance are also discussed. Perspects of effective laboratory experiments and computer-based simulation are finally investigated, demonstrating many demanding areas for enhanced research efforts, which include the screening of multi-functional additives, volatile organiccompound emission control, necessity of modeling and post-modeling analysis, and usefulness of developing more conjunctive AI-based process control techniques. Copyright © 2013 Elsevier Ltd. All rights reserved.

Results and Insights on the Impact of Smoke on Digital Instrumentation and Control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanaka, T. J.; Nowlen, S. P.

2001-01-31

Smoke can cause interruptions and upsets in active electronics. Because nuclear power plants are replacing analog with digital instrumentation and control systems, qualification guidelines for new systems are being reviewed for severe environments such as smoke and electromagnetic interference. Active digital systems, individual components, and active circuits have been exposed to smoke in a program sponsored by the U.S. Nuclear Regulatory Commission. The circuits and systems were all monitored during the smoke exposure, indicating any immediate effects of the smoke. The major effect of smoke has been to increase leakage currents (through circuit bridging across contacts and leads) and tomore » cause momentary upsets and failures in digital systems. This report summarizes two previous reports and presents new results from conformal coating, memory chip, and hard drive tests. The report describes practices for mitigation of smoke damage through digital system design, fire barriers, ventilation, fire suppressants, and post fire procedures.« less

Double-layer effects on the lifetime of newly developed HBC-foils for RCS of J-PARC

NASA Astrophysics Data System (ADS)

Sugai, I.; Takeda, Y.; Oyaizu, M.; Kawakami, H.; Irie, Y.; Takagi, A.; Hattori, H.; Kawasaki, K.

2010-02-01

We have developed hybrid type boron-mixed carbon (HBC) foils for the rapid cycling synchrotron (RCS) of Japan-proton accelerator research complex (J-PARC) using the controlled DC arc-discharge method. The method has been found suitable for the production of thick foils up to a maximum of 700 μg/cm 2 due to the strong adhesion to the substrate. The foils thus produced showed rather long lifetime. By the development, high-temperature damage (foil deformation, thickness reduction and pinhole formation) of the foil was significantly mitigated even at a temperature of approximately 1700 K. However, when the foil temperature was higher than about 1800 K, especially pinhole formation in the irradiated area of the foil and its peripheries were always observed. In order to relieve high-temperature damage, we investigated the possibility to lower the temperature rise in single and double layer HBC-foils while keeping the total thickness the same. We also compared the lifetime of the single and the double layer HBC-foils as well as diamond and commercially available foils, using a 3.2 MeV Ne + ion beam from the Van de Graaff accelerator.

Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming.

PubMed

Matsakas, Antonios; Yadav, Vikas; Lorca, Sabina; Narkar, Vihang

2013-10-01

Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-associated glycoprotein complex (DAG) has been clinically challenging. Instead, identifying and targeting muscle pathways deregulated in DMD will provide new therapeutic avenues. We report that the expression of nuclear receptor estrogen-related receptor-γ (ERRγ), and its metabolic and angiogenic targets are down-regulated (50-85%) in skeletal muscles of mdx mice (DMD model) vs. wild-type mice. Corelatively, oxidative myofibers, muscle vasculature, and exercise tolerance (33%) are decreased in mdx vs. wild-type mice. Overexpressing ERRγ selectively in the dystrophic muscles of the mdx mice restored metabolic and angiogenic gene expression compared with control mdx mice. Further, ERRγ enhanced muscle oxidative myofibers, vasculature, and blood flow (by 33-66%) and improved exercise tolerance (by 75%) in the dystrophic mice. Restoring muscle ERRγ pathway ameliorated muscle damage and also prevented DMD hallmarks of postexercise muscle damage, hypoxia, and fatigue in mdx mice. Notably, ERRγ did not restore sarcolemmal DAG complex, which is thus dispensable for antidystrophic effects of ERRγ. In summary, ERRγ-dependent metabolic and angiogenic gene program is defective in DMD, and we demonstrate that its restoration is a potential strategy for treating muscular dystrophy.

No more business as usual: enticing companies to sharply lower the public health costs of the products they sell.

PubMed

Sugarman, S

2009-03-01

Cigarettes, alcohol, junk food and motor vehicles cause a staggeringly high level of death, injury and disease. Business leaders from the industries that make these products currently try to frame these negative outcomes as 'collateral damage' that is someone else's problem. That framing is not only morally objectionable, but also overlooks the possibility that, with proper prodding, industry could substantially mitigate these public health disasters. A promising regulatory tool called 'performance-based regulation' is a new approach to combating the problem. Simply put, performance-based regulation would impose a legal obligation on manufacturers to reduce their negative social costs. Rather than suing the firms for damages, or telling them how they should run their businesses differently (as typical 'command and control' regimes do), performance-based regulation allows the firms to determine how best to decrease today's negative public health consequences. Like other public health strategies, performance-based regulation shifts the focus away from individual consumers on to those who are far more likely to achieve real public health gains. Analogous to a tax on causing harm that exceeds a threshold level, performance-based regulation seeks to harness private initiative in pursuit of the public good.

4D Imaging in Thermally Damaged Polymer-bonded Explosives

NASA Astrophysics Data System (ADS)

Parker, Gary; Bourne, Neil; Eastwood, David; Jacques, Simon; Dickson, Peter; Lopez-Pulliam, Ian; Heatwole, Eric; Holmes, Matt; Smilowitz, Laura; Rau, Christoph

2017-06-01

PBXs are composites in which explosive crystallites are bound by compliant polymers. There are safety benefits derived from compliant binders; e.g. they mitigate some effects of mechanical insult. However, during elevated thermal insult, degradation of binder and HE crystallites can modify the morphology in ways that can reduce safety margins by increasing post-ignition reaction violence. The response of thermally damaged PBXs, before and following self-ignition has safety implications and it is desirable to understand the fundamental physics controlling the rate of pre-ignition thermal runaway and the post-ignition flame propagation in thermal accident scenarios. Coupled with this there is an ongoing effort to make in situ, time-resolved, measurements of the size, nature and extent of micro-porosity in PBX 9501 during thermal decomposition. We report on PBX heating experiments conducted at the Diamond synchrotron with both PBX 9501 and an inert mock. During heating, CT radiography was conducted in order to observe void production and interconnectivity of gas flow pathways, as well as to monitor phase changes within the crystals. We explore the variation of behavior as a function of heating rate, soak temperature, soak time and confinement.

Practical Application of a Subscale Transport Aircraft for Flight Research in Control Upset and Failure Conditions

NASA Technical Reports Server (NTRS)

Cunningham, Kevin; Foster, John V.; Morelli, Eugene A.; Murch, Austin M.

2008-01-01

Over the past decade, the goal of reducing the fatal accident rate of large transport aircraft has resulted in research aimed at the problem of aircraft loss-of-control. Starting in 1999, the NASA Aviation Safety Program initiated research that included vehicle dynamics modeling, system health monitoring, and reconfigurable control systems focused on flight regimes beyond the normal flight envelope. In recent years, there has been an increased emphasis on adaptive control technologies for recovery from control upsets or failures including damage scenarios. As part of these efforts, NASA has developed the Airborne Subscale Transport Aircraft Research (AirSTAR) flight facility to allow flight research and validation, and system testing for flight regimes that are considered too risky for full-scale manned transport airplane testing. The AirSTAR facility utilizes dynamically-scaled vehicles that enable the application of subscale flight test results to full scale vehicles. This paper describes the modeling and simulation approach used for AirSTAR vehicles that supports the goals of efficient, low-cost and safe flight research in abnormal flight conditions. Modeling of aerodynamics, controls, and propulsion will be discussed as well as the application of simulation to flight control system development, test planning, risk mitigation, and flight research.

Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries

PubMed Central

Kulkarni, Shilpa; Wang, Timothy C.; Guha, Chandan

2016-01-01

Purpose of review Therapeutic exposure to high doses of radiation can severely impair organ function due to ablation of stem cells. Normal tissue injury is a dose-limiting toxicity for radiation therapy (RT). Although advances in the delivery of high precision conformal RT has increased normal tissue sparing, mitigating and therapeutic strategies that could alleviate early and chronic radiation effects are urgently needed in order to deliver curative doses of RT, especially in abdominal, pelvic and thoracic malignancies. Radiation-induced gastrointestinal injury is also a major cause of lethality from accidental or intentional exposure to whole body irradiation in the case of nuclear accidents or terrorism. This review examines the therapeutic options for mitigation of non-hematopoietic radiation injuries. Recent findings We have developed stem cell based therapies for the mitigation of acute radiation syndrome (ARS) and radiation-induced gastrointestinal syndrome (RIGS). This is a promising option because of the robustness of standardized isolation and transplantation of stromal cells protocols, and their ability to support and replace radiation-damaged stem cells and stem cell niche. Stromal progenitor cells (SPC) represent a unique multipotent and heterogeneous cell population with regenerative, immunosuppressive, anti-inflammatory, and wound healing properties. SPC are also known to secrete various key cytokines and growth factors such as platelet derived growth factors (PDGF), keratinocyte growth factor (KGF), R-spondins (Rspo), and may consequently exert their regenerative effects via paracrine function. Additionally, secretory vesicles such as exosomes or microparticles can potentially be a cell-free alternative replacing the cell transplant in some cases. Summary This review highlights the beneficial effects of SPC on tissue regeneration with their ability to (a) target the irradiated tissues, (b) recruit host stromal cells, (c) regenerate endothelium and epithelium, (d) and secrete regenerative and immunomodulatory paracrine signals to control inflammation, ulceration, wound healing and fibrosis. PMID:28462013

An Approach to Risk-Based Design Incorporating Damage Tolerance Analyses

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Glaessgen, Edward H.; Sleight, David W.

2002-01-01

Incorporating risk-based design as an integral part of spacecraft development is becoming more and more common. Assessment of uncertainties associated with design parameters and environmental aspects such as loading provides increased knowledge of the design and its performance. Results of such studies can contribute to mitigating risk through a system-level assessment. Understanding the risk of an event occurring, the probability of its occurrence, and the consequences of its occurrence can lead to robust, reliable designs. This paper describes an approach to risk-based structural design incorporating damage-tolerance analysis. The application of this approach to a candidate Earth-entry vehicle is described. The emphasis of the paper is on describing an approach for establishing damage-tolerant structural response inputs to a system-level probabilistic risk assessment.

Comprehensive, Quantitative Risk Assessment of CO{sub 2} Geologic Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lepinski, James

2013-09-30

A Quantitative Failure Modes and Effects Analysis (QFMEA) was developed to conduct comprehensive, quantitative risk assessments on CO{sub 2} capture, transportation, and sequestration or use in deep saline aquifers, enhanced oil recovery operations, or enhanced coal bed methane operations. The model identifies and characterizes potential risks; identifies the likely failure modes, causes, effects and methods of detection; lists possible risk prevention and risk mitigation steps; estimates potential damage recovery costs, mitigation costs and costs savings resulting from mitigation; and ranks (prioritizes) risks according to the probability of failure, the severity of failure, the difficulty of early failure detection and themore » potential for fatalities. The QFMEA model generates the necessary information needed for effective project risk management. Diverse project information can be integrated into a concise, common format that allows comprehensive, quantitative analysis, by a cross-functional team of experts, to determine: What can possibly go wrong? How much will damage recovery cost? How can it be prevented or mitigated? What is the cost savings or benefit of prevention or mitigation? Which risks should be given highest priority for resolution? The QFMEA model can be tailored to specific projects and is applicable to new projects as well as mature projects. The model can be revised and updated as new information comes available. It accepts input from multiple sources, such as literature searches, site characterization, field data, computer simulations, analogues, process influence diagrams, probability density functions, financial analysis models, cost factors, and heuristic best practices manuals, and converts the information into a standardized format in an Excel spreadsheet. Process influence diagrams, geologic models, financial models, cost factors and an insurance schedule were developed to support the QFMEA model. Comprehensive, quantitative risk assessments were conducted on three (3) sites using the QFMEA model: (1) SACROC Northern Platform CO{sub 2}-EOR Site in the Permian Basin, Scurry County, TX, (2) Pump Canyon CO{sub 2}-ECBM Site in the San Juan Basin, San Juan County, NM, and (3) Farnsworth Unit CO{sub 2}-EOR Site in the Anadarko Basin, Ochiltree County, TX. The sites were sufficiently different from each other to test the robustness of the QFMEA model.« less

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

40 CFR 68.39 - Documentation.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., and the rationale for selection; assumptions shall include use of any administrative controls and any... include the anticipated effect of the controls and mitigation on the release quantity and rate. (b) For... administrative controls and any mitigation that were assumed to limit the quantity that could be released...

Semi Active Control of Civil Structures, Analytical and Numerical Studies

NASA Astrophysics Data System (ADS)

Kerboua, M.; Benguediab, M.; Megnounif, A.; Benrahou, K. H.; Kaoulala, F.

Structural control for civil structures was born out of a need to provide safer and more efficient designs with the reality of limited resources. The purpose of structural control is to absorb and to reflect the energy introduced by dynamic loads such as winds, waves, earthquakes, and traffic. Today, the protection of civil structures from severe dynamic loading is typically achieved by allowing the structures to be damaged. Semi-active control devices, also called "smart" control devices, assume the positive aspects of both the passive and active control devices. A semi-active control strategy is similar to the active control strategy. Only here, the control actuator does not directly apply force to the structure, but instead it is used to control the properties of a passive energy device, a controllable passive damper. Semi-active control strategies can be used in many of the same civil applications as passive and active control. One method of operating smart cable dampers is in a purely passive capacity, supplying the dampers with constant optimal voltage. The advantages to this strategy are the relative simplicity of implementing the control strategy as compared to a smart or active control strategy and that the dampers are more easily optimally tuned in- place, eliminating the need to have passive dampers with unique optimal damping coefficients. This research investigated semi-active control of civil structures for natural hazard mitigation. The research has two components, the seismic protection of buildings and the mitigation of wind-induced vibration in structures. An ideal semi-active motion equation of a composite beam that consists of a cantilever beam bonded with a PZT patch using Hamilton's principle and Galerkin's method was treated. A series R-L and a parallel R-L shunt circuits are coupled into the motion equation respectively by means of the constitutive relation of piezoelectric material and Kirchhoff's law to control the beam vibration. A numerical example of the parallel R-L piezoelectric vibration shunt control simulated with MATLAB® is presented. An analytical study of the resistor-inductor (R-L) passive piezoelectric vibration shunt control of a cantilever beam was undertaken. The modal and strain analyses were performed by varying the material properties and geometric configurations of the piezoelectric transducer in relation to the structure in order to maximize the mechanical strain produced in the piezoelectric transducer.

A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa.

PubMed

Tjahjono, Elissa; Kirienko, Natalia V

2017-06-01

All living organisms exist in a precarious state of homeostasis that requires constant maintenance. A wide variety of stresses, including hypoxia, heat, and infection by pathogens perpetually threaten to imbalance this state. Organisms use a battery of defenses to mitigate damage and restore normal function. Previously, we described a Caenorhabditis elegans-Pseudomonas aeruginosa assay (Liquid Killing) in which toxicity to the host is dependent upon the secreted bacterial siderophore pyoverdine. Although pyoverdine is also indispensable for virulence in mammals, its cytological effects are unclear. We used genetics, transcriptomics, and a variety of pathogen and chemical exposure assays to study the interactions between P. aeruginosa and C. elegans. Although P. aeruginosa can kill C. elegans through at least 5 different mechanisms, the defense responses activated by Liquid Killing are specific and selective and have little in common with innate defense mechanisms against intestinal colonization. Intriguingly, the defense response utilizes the phylogenetically-conserved ESRE (Ethanol and Stress Response Element) network, which we and others have previously shown to mitigate damage from a variety of abiotic stresses. This is the first report of this networks involvement in innate immunity, and indicates that host innate immune responses overlap with responses to abiotic stresses. The upregulation of the ESRE network in C. elegans is mediated in part by a family of bZIP proteins (including ZIP-2, ZIP-4, CEBP-1, and CEBP-2) that have overlapping and unique functions. Our data convincingly show that, following exposure to P. aeruginosa, the ESRE defense network is activated by mitochondrial damage, and that mitochondrial damage also leads to ESRE activation in mammals. This establishes a role for ESRE in a phylogenetically-conserved mitochondrial surveillance system important for stress response and innate immunity.

Double side read-out technique for mitigation of radiation damage effects in PbWO 4 crystals

DOE PAGES

Lucchini, Marco Toliman; Auffray, E.; Benaglia, A.; ...

2016-04-18

Test beam results of a calorimetric module based on 3×3×22 cm 3 PbWO 4 crystals, identical to those used in the CMS ECAL Endcaps, read out by a pair of photodetectors coupled to the two opposite sides (front and rear) of each crystal are presented. Nine crystals with different level of induced absorption, from 0 to 20 m -1, have been tested using electrons in the 50–200 GeV energy range. Photomultiplier tubes have been chosen as photodetectors to allow for a precise measurement of highly damaged crystals. The information provided by this double side read-out configuration allows to correct formore » event-by-event fluctuations of the longitudinal development of electromagnetic showers. By strongly mitigating the effect of non-uniform light collection efficiency induced by radiation damage, the double side read-out technique significantly improves the energy resolution with respect to a single side read-out configuration. The non-linearity of the response arising in damaged crystals is also corrected by a double side read-out configuration and the response linearity of irradiated crystals is restored. In high radiation environments at future colliders, as it will be the case for detectors operating during the High Luminosity phase of the Large Hadron Collider, defects can be created inside the scintillator volume leading to a non-uniform response of the calorimetric cell. As a result, the double side read-out technique presented in this study provides a valuable way to improve the performance of calorimeters based on scintillators whose active volumes are characterized by high aspect ratio cells similar to those used in this study.« less

Double side read-out technique for mitigation of radiation damage effects in PbWO 4 crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lucchini, Marco Toliman; Auffray, E.; Benaglia, A.

Test beam results of a calorimetric module based on 3×3×22 cm 3 PbWO 4 crystals, identical to those used in the CMS ECAL Endcaps, read out by a pair of photodetectors coupled to the two opposite sides (front and rear) of each crystal are presented. Nine crystals with different level of induced absorption, from 0 to 20 m -1, have been tested using electrons in the 50–200 GeV energy range. Photomultiplier tubes have been chosen as photodetectors to allow for a precise measurement of highly damaged crystals. The information provided by this double side read-out configuration allows to correct formore » event-by-event fluctuations of the longitudinal development of electromagnetic showers. By strongly mitigating the effect of non-uniform light collection efficiency induced by radiation damage, the double side read-out technique significantly improves the energy resolution with respect to a single side read-out configuration. The non-linearity of the response arising in damaged crystals is also corrected by a double side read-out configuration and the response linearity of irradiated crystals is restored. In high radiation environments at future colliders, as it will be the case for detectors operating during the High Luminosity phase of the Large Hadron Collider, defects can be created inside the scintillator volume leading to a non-uniform response of the calorimetric cell. As a result, the double side read-out technique presented in this study provides a valuable way to improve the performance of calorimeters based on scintillators whose active volumes are characterized by high aspect ratio cells similar to those used in this study.« less

Epoetin beta pegol alleviates oxidative stress and exacerbation of renal damage from iron deposition, thereby delaying CKD progression in progressive glomerulonephritis rats.

PubMed

Hirata, Michinori; Tashiro, Yoshihito; Aizawa, Ken; Kawasaki, Ryohei; Shimonaka, Yasushi; Endo, Koichi

2015-12-01

The increased deposition of iron in the kidneys that occurs with glomerulopathy hinders the functional and structural recovery of the tubules and promotes progression of chronic kidney disease (CKD). Here, we evaluated whether epoetin beta pegol (continuous erythropoietin receptor activator: CERA), which has a long half-life in blood and strongly suppresses hepcidin-25, exerts renoprotection in a rat model of chronic progressive glomerulonephritis (cGN). cGN rats showed elevated urinary total protein excretion (uTP) and plasma urea nitrogen (UN) from day 14 after the induction of kidney disease (day 0) and finally declined into end-stage kidney disease (ESKD), showing reduced creatinine clearance with glomerulosclerosis, tubular dilation, and tubulointerstitial fibrosis. A single dose of CERA given on day 1, but not on day 16, alleviated increasing uTP and UN, thereby delaying ESKD. In the initial disease phase, CERA significantly suppressed urinary 8-OHdG and liver-type fatty acid-binding protein (L-FABP), a tubular damage marker. CERA also inhibited elevated plasma hepcidin-25 levels and alleviated subsequent iron accumulation in kidneys in association with elevated urinary iron excretion and resulted in alleviation of growth of Ki67-positive tubular and glomerular cells. In addition, at day 28 when the exacerbation of uTP occurs, a significant correlation was observed between iron deposition in the kidney and urinary L-FABP. In our study, CERA mitigated increasing kidney damage, thereby delaying CKD progression in this glomerulonephritis rat model. Alleviation by CERA of the exacerbation of kidney damage could be attributable to mitigation of tubular damage that might occur with lowered iron deposition in tubules. © 2015 Chugai Pharmaceutical Co., Ltd. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Characteristics of the 2011 Tohoku Tsunami and introduction of two level tsunamis for tsunami disaster mitigation

PubMed Central

SATO, Shinji

2015-01-01

Characteristics of the 2011 Tohoku Tsunami have been revealed by collaborative tsunami surveys extensively performed under the coordination of the Joint Tsunami Survey Group. The complex behaviors of the mega-tsunami were characterized by the unprecedented scale and the low occurrence frequency. The limitation and the performance of tsunami countermeasures were described on the basis of tsunami surveys, laboratory experiments and numerical analyses. These findings contributed to the introduction of two-level tsunami hazards to establish a new strategy for tsunami disaster mitigation, combining structure-based flood protection designed by the Level-1 tsunami and non-structure-based damage reduction planned by the Level-2 tsunami. PMID:26062739

Characteristics of the 2011 Tohoku Tsunami and introduction of two level tsunamis for tsunami disaster mitigation.

PubMed

Sato, Shinji

2015-01-01

Characteristics of the 2011 Tohoku Tsunami have been revealed by collaborative tsunami surveys extensively performed under the coordination of the Joint Tsunami Survey Group. The complex behaviors of the mega-tsunami were characterized by the unprecedented scale and the low occurrence frequency. The limitation and the performance of tsunami countermeasures were described on the basis of tsunami surveys, laboratory experiments and numerical analyses. These findings contributed to the introduction of two-level tsunami hazards to establish a new strategy for tsunami disaster mitigation, combining structure-based flood protection designed by the Level-1 tsunami and non-structure-based damage reduction planned by the Level-2 tsunami.

On effectiveness of network sensor-based defense framework

NASA Astrophysics Data System (ADS)

Zhang, Difan; Zhang, Hanlin; Ge, Linqiang; Yu, Wei; Lu, Chao; Chen, Genshe; Pham, Khanh

2012-06-01

Cyber attacks are increasing in frequency, impact, and complexity, which demonstrate extensive network vulnerabilities with the potential for serious damage. Defending against cyber attacks calls for the distributed collaborative monitoring, detection, and mitigation. To this end, we develop a network sensor-based defense framework, with the aim of handling network security awareness, mitigation, and prediction. We implement the prototypical system and show its effectiveness on detecting known attacks, such as port-scanning and distributed denial-of-service (DDoS). Based on this framework, we also implement the statistical-based detection and sequential testing-based detection techniques and compare their respective detection performance. The future implementation of defensive algorithms can be provisioned in our proposed framework for combating cyber attacks.

Envy Up, Scorn Down: How Comparison Divides Us

PubMed Central

Fiske, Susan T.

2013-01-01

Comparison compels people, even as it stresses, depresses, and divides us. Comparison is only natural, but the collateral damage reveals envy upward and scorn downward, and these emotions, arguably, poison people and their relationships. Summaries of several experiments—using questionnaire, psychometric, response-time, electromyographic, and neuroimaging data—illustrate the dynamics of envy up and scorn down, as well as proposing how to mitigate their effects. Initial studies suggest the importance of status. Other data show how scorn down minimizes thought about another’s mind; power deactivates mental concepts. Regarding envy up, other studies demonstrate that Schadenfreude (malicious joy) targets envied outgroups. However, counterstereotypic information, empathy, and outcome dependency can mitigate both scorn and envy. PMID:21058760

The push–pull tactic for mitigation of mountain pine beetle (Coleoptera: Curculionidae) damage in lodgepole and whitebark pines

Treesearch

Nancy E. Gillette; Constance J. Mehmel; Sylvia R. Mori; Jeffrey N. Webster; David L. Wood; Nadir Erbilgin; Donald R. Owen

2012-01-01

In an attempt to improve semiochemical-based treatments for protecting forest stands from bark beetle attack, we compared push-pull versus push-only tactics for protecting lodgepole pine (Pinus contorta Douglas ex Loudon) and whitebark pine (Pinus albicaulis Engelm.) stands from attack by mountain pine beetle (...

Linking ecology and aesthetics in sustainable agricultural landscapes: Lessons from the Palouse region of Washington, U.S.A

Treesearch

Linda R. Klein; William G. Hendrix; Virginia I. Lohr; Jolie B. Kaytes; Rodney D. Sayler; Mark E. Swanson; William J. Elliot; John P. Reganold

2015-01-01

Inspired by international escalation in agricultural sustainability debates, we explored the promise of landscape-scale conservation buffers to mitigate environmental damage, improve ecological function, and enhance scenic quality. Although the ecological benefits of buffer vegetation are well established by plot- and field-scale research, buffer adoption by farmers is...

Cumulative watershed effects of fuel management in the western United States

Treesearch

William J. Elliot; Ina Sue Miller; Lisa Audin

2010-01-01

Fire suppression in the last century has resulted in forests with excessive amounts of biomass, leading to more severe wildfires, covering greater areas, requiring more resources for suppression and mitigation, and causing increased onsite and offsite damage to forests and watersheds. Forest managers are now attempting to reduce this accumulated biomass by thinning,...

Natural Disasters and Adaptive Capacity. OECD Development Centre Working Paper No. 237

ERIC Educational Resources Information Center

Dayton-Johnson, Jeff

2004-01-01

Natural disasters (droughts, earthquakes, epidemics, floods, wind storms) damage wellbeing, both in their immediate and long-term aftermath, and because the insecurity of exposure to disasters is in itself harmful to risk-averse people. As such, mitigating and coping with the risk of natural disasters is a pressing issue for economic development.…

33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

Code of Federal Regulations, 2011 CFR

2011-07-01

... sections of the plan dealing with exercises, the spill management team, and the qualified individual. 1... mitigation measures— 2.2.5.1Ship salvage procedures; 2.2.5.2Damage stability; and 2.2.5.3Hull stress... and facility personnel to the spill management team. 2.2.7Familiarity with the operational...

33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

Code of Federal Regulations, 2013 CFR

2013-07-01

... sections of the plan dealing with exercises, the spill management team, and the qualified individual. 1... mitigation measures— 2.2.5.1Ship salvage procedures; 2.2.5.2Damage stability; and 2.2.5.3Hull stress... and facility personnel to the spill management team. 2.2.7Familiarity with the operational...

33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

Code of Federal Regulations, 2014 CFR

2014-07-01

... sections of the plan dealing with exercises, the spill management team, and the qualified individual. 1... mitigation measures— 2.2.5.1Ship salvage procedures; 2.2.5.2Damage stability; and 2.2.5.3Hull stress... and facility personnel to the spill management team. 2.2.7Familiarity with the operational...

33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

Code of Federal Regulations, 2012 CFR

2012-07-01

... sections of the plan dealing with exercises, the spill management team, and the qualified individual. 1... mitigation measures— 2.2.5.1Ship salvage procedures; 2.2.5.2Damage stability; and 2.2.5.3Hull stress... and facility personnel to the spill management team. 2.2.7Familiarity with the operational...

Defensible space in the news: public discussion of a neglected topic

Treesearch

Jayne Fingerman Johnson; David N. Bengston; David P. Fan

2006-01-01

Managers have an opportunity during times of peak media coverage of wildfire to expand the discussion about defensible space from the current focus on vegetation clearing to include the full range of activities a homeowner can undertake to mitigate damage. Currently, news media discussion of wildfire is overwhelmingly dominated by firefighting, and discussion of...

Reverse bias protected solar array with integrated bypass battery

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A (Inventor)

2012-01-01

A method for protecting the photovoltaic cells in a photovoltaic (PV) array from reverse bias damage by utilizing a rechargeable battery for bypassing current from a shaded photovoltaic cell or group of cells, avoiding the need for a bypass diode. Further, the method mitigates the voltage degradation of a PV array caused by shaded cells.

Radon and lung cancer: assessing and mitigating the risk.

PubMed

Choi, Humberto; Mazzone, Peter

2014-09-01

Radon is a naturally occurring radioactive gas. Its progenies emit alpha particles capable of causing tissue damage. Radon exposure is estimated to be the second most common cause of lung cancer in the United States. Management of patients with a history of radon exposure should involve a lung cancer specialist. Copyright© 2014 The Cleveland Clinic Foundation.

Bullying and Mobbing in Academe: Challenges for Distance Education and Social Media Applications

ERIC Educational Resources Information Center

Oravec, Jo Ann

2012-01-01

Bullying and mobbing are migrating to online realms, intensifying the damage involved and increasing the complexities of these issues. Social media (such as Facebook and Twitter) are intensely communal in many senses; they may serve to increase the negative aspects of bullying and mobbing as well as provide community-oriented tools for mitigation.…

78 FR 67382 - North Carolina; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

... Stafford Act for Hazard Mitigation will be limited to 75 percent of the total eligible costs. Federal funds... Presidential declaration of a major disaster for the State of North Carolina (FEMA-4153-DR), dated October 29.... (the ``Stafford Act''), as follows: I have determined that the damage in certain areas of the State of...

Wildfire communication and climate risk mitigation

Treesearch

Robyn S. Wilson; Sarah M. McCaffrey; Eric Toman

2017-01-01

Throughout the late 19th century and most of the 20th century, risks associated with wildfire were addressed by suppressing fires as quickly as possible. However, by the 1960s, it became clear that fire exclusion policies were having adverse effects on ecological health, as well as contributing to larger and more damaging wildfires over time. Although federal fire...

A Dynamic Model for the Evaluation of Aircraft Engine Icing Detection and Control-Based Mitigation Strategies

NASA Technical Reports Server (NTRS)

Simon, Donald L.; Rinehart, Aidan W.; Jones, Scott M.

2017-01-01

Aircraft flying in regions of high ice crystal concentrations are susceptible to the buildup of ice within the compression system of their gas turbine engines. This ice buildup can restrict engine airflow and cause an uncommanded loss of thrust, also known as engine rollback, which poses a potential safety hazard. The aviation community is conducting research to understand this phenomena, and to identify avoidance and mitigation strategies to address the concern. To support this research, a dynamic turbofan engine model has been created to enable the development and evaluation of engine icing detection and control-based mitigation strategies. This model captures the dynamic engine response due to high ice water ingestion and the buildup of ice blockage in the engines low pressure compressor. It includes a fuel control system allowing engine closed-loop control effects during engine icing events to be emulated. The model also includes bleed air valve and horsepower extraction actuators that, when modulated, change overall engine operating performance. This system-level model has been developed and compared against test data acquired from an aircraft turbofan engine undergoing engine icing studies in an altitude test facility and also against outputs from the manufacturers customer deck. This paper will describe the model and show results of its dynamic response under open-loop and closed-loop control operating scenarios in the presence of ice blockage buildup compared against engine test cell data. Planned follow-on use of the model for the development and evaluation of icing detection and control-based mitigation strategies will also be discussed. The intent is to combine the model and control mitigation logic with an engine icing risk calculation tool capable of predicting the risk of engine icing based on current operating conditions. Upon detection of an operating region of risk for engine icing events, the control mitigation logic will seek to change the engines operating point to a region of lower risk through the modulation of available control actuators while maintaining the desired engine thrust output. Follow-on work will assess the feasibility and effectiveness of such control-based mitigation strategies.

Understanding Earthquake Hazard & Disaster in Himalaya - A Perspective on Earthquake Forecast in Himalayan Region of South Central Tibet

NASA Astrophysics Data System (ADS)

Shanker, D.; Paudyal, ,; Singh, H.

2010-12-01

It is not only the basic understanding of the phenomenon of earthquake, its resistance offered by the designed structure, but the understanding of the socio-economic factors, engineering properties of the indigenous materials, local skill and technology transfer models are also of vital importance. It is important that the engineering aspects of mitigation should be made a part of public policy documents. Earthquakes, therefore, are and were thought of as one of the worst enemies of mankind. Due to the very nature of release of energy, damage is evident which, however, will not culminate in a disaster unless it strikes a populated area. The word mitigation may be defined as the reduction in severity of something. The Earthquake disaster mitigation, therefore, implies that such measures may be taken which help reduce severity of damage caused by earthquake to life, property and environment. While “earthquake disaster mitigation” usually refers primarily to interventions to strengthen the built environment, and “earthquake protection” is now considered to include human, social and administrative aspects of reducing earthquake effects. It should, however, be noted that reduction of earthquake hazards through prediction is considered to be the one of the effective measures, and much effort is spent on prediction strategies. While earthquake prediction does not guarantee safety and even if predicted correctly the damage to life and property on such a large scale warrants the use of other aspects of mitigation. While earthquake prediction may be of some help, mitigation remains the main focus of attention of the civil society. Present study suggests that anomalous seismic activity/ earthquake swarm existed prior to the medium size earthquakes in the Nepal Himalaya. The mainshocks were preceded by the quiescence period which is an indication for the occurrence of future seismic activity. In all the cases, the identified episodes of anomalous seismic activity were characterized by an extremely high annual earthquake frequency as compared to the preceding normal and the following gap episodes, and is the characteristics of the events in such an episode is causally related with the magnitude and the time of occurrence of the forthcoming earthquake. It is observed here that for the shorter duration of the preparatory time period, there will be the smaller mainshock, and vice-versa. The Western Nepal and the adjoining Tibet region are potential for the future medium size earthquakes. Accordingly, it has been estimated here that an earthquake with M 6.5 ± 0.5 may occur at any time from now onwards till December 2011 in the Western Nepal within an area bounded by 29.3°-30.5° N and 81.2°-81.9° E, in the focal depth range 10 -30 km.

IAA-producing Penicillium sp. NICS01 triggers plant growth and suppresses Fusarium sp.-induced oxidative stress in sesame (Sesamum indicum L.).

PubMed

Radhakrishnan, Ramalingam; Shim, Kang-Bo; Lee, Byeong-Won; Hwang, Chung-Dong; Pae, Suk-Bok; Park, Chang-Hwan; Kim, Sung-Up; Lee, Choon-Ki; Baek, In-Youl

2013-06-28

Application of rhizospheric fungi is an effective and environmentally friendly method of improving plant growth and controlling many plant diseases. The current study was aimed to identify phytohormone-producing fungi from soil, to understand their roles in sesame plant growth, and to control Fusarium disease. Three predominant fungi (PNF1, PNF2, and PNF3) isolated from the rhizospheric soil of peanut plants were screened for their growth-promoting efficiency on sesame seedlings. Among these isolates, PNF2 significantly increased the shoot length and fresh weight of seedlings compared with controls. Analysis of the fungal culture filtrate showed a higher concentration of indole acetic acid in PNF2 than in the other isolates. PNF2 was identified as Penicillium sp. on the basis of phylogenetic analysis of ITS sequence similarity. The in vitro biocontrol activity of Penicillium sp. against Fusarium sp. was exhibited by a 49% inhibition of mycelial growth in a dual culture bioassay and by hyphal injuries as observed by scanning electron microscopy. In addition, greenhouse experiments revealed that Fusarium inhibited growth in sesame plants by damaging lipid membranes and reducing protein content. Co-cultivation with Penicillium sp. mitigated Fusarium-induced oxidative stress in sesame plants by limiting membrane lipid peroxidation, and by increasing the protein concentration, levels of antioxidants such as total polyphenols, and peroxidase and polyphenoloxidase activities. Thus, our findings suggest that Penicillium sp. is a potent plant growthpromoting fungus that has the ability to ameliorate damage caused by Fusarium infection in sesame cultivation.

Research Contributing to Improvements in Controlling Florida’s Mosquitoes and Mosquito-Borne Diseases

PubMed Central

Tabachnick, Walter J.

2016-01-01

Research on mosquitoes and mosquito-borne diseases has contributed to improvements in providing effective, efficient, and environmentally proper mosquito control. Florida has benefitted from several research accomplishments that have increased the state’s mosquito control capabilities. Research with Florida’s mosquitoes has resulted in the development of ecologically sound management of mosquito impoundments on Florida’s east coast. This strategy, called Rotational Impoundment Management (RIM), has improved the ability to target the delivery of pesticides and has helped to reduce non-target effects and environmental damage. Research has led to the development of an arbovirus surveillance system which includes sentinel chicken surveillance, real time use of environmental contributing factors like meteorology and hydrology to target mosquito control, as well as public health efforts to mitigate disease outbreaks to areas with risk of disease. These research driven improvements have provided substantial benefits to all of Florida. More research is needed to meet the future challenges to reduce emerging pathogens like Zika virus and the consequences of environmental changes like global climate change that are likely to influence the effects of mosquito-borne pathogens on human health and well-being. PMID:27690112

The net benefit of public expenditures on avalanche defence structures in the municipality of Davos, Switzerland

NASA Astrophysics Data System (ADS)

Fuchs, S.; McAlpin, M. C.

2005-04-01

Avalanches pose a threat to settlements as well as industrial and recreational areas in the Alps. As a counter measure, technical mitigation measures have been implemented since the 19th century, resulting in a raise in value of formerly endangered areas. This increase in value can be considered as a benefit due to prevented damage. This paper compares the total costs and benefits of technical mitigation measures in the municipality of Davos, Switzerland as a basis for evaluating their net social benefit. The benefit of avalanche defence structures is determined using two different approaches. First, the replacement value of buildings protected by mitigation measures is quantified. Second, the number of protected persons is monetarily assessed by means of a human capital approach. The quantified benefit is compared with the present value of cumulative capital expenditures on avalanche mitigation measures. In addition, distributional effects of the public expenditures on technical mitigation measures are discussed based on the average future tax revenues within protected areas. Depending on whether benefits are calculated in terms of protected buildings or protected persons, the results show a large range of cost-benefit ratios. Critical issues of cost-benefit analyses in the context of alpine natural hazards are highlighted, including problems related to the human capital approach and the sensitivity of results to how benefits are calculated. The applicability of cost-benefit analyses for evaluating avalanche mitigation measures is discussed.

Ethical questions in landslide management and risk reduction in Norway

NASA Astrophysics Data System (ADS)

Taurisano, A.; Lyche, E.; Thakur, V.; Wiig, T.; Øvrelid, K.; Devoli, G.

2012-04-01

The loss of lives caused by landslides in Norway is smaller than in other countries due to the low population density in exposed areas. However, annual economic losses from damage to properties and infrastructures are vast. Yet nationally coordinated efforts to manage and reduce landslide and snow avalanche risk are a recent challenge, having started only in the last decade. Since 2009, this has been a task of the Norwegian Water Resources and Energy Directorate (NVE) under the Ministry of Petroleum and Energy. Ongoing work includes collection of landslide data, production of susceptibility and hazard maps, planning of mitigation measures along with monitoring and early warning systems, assistance to areal planning, providing expertise in emergencies and disseminating information to the public. These activities are realized in collaboration with the Norwegian Geological Survey (NGU), the Meteorological Institute, the Road and Railway authorities, universities and private consultant companies. As the total need for risk mitigating initiatives is by far larger than the annual budget, priority assessment is crucial. This brings about a number of ethical questions. 1. Susceptibility maps have been produced for the whole country and provide a first indication of areas with potential landslide or snow avalanche hazard, i.e. areas where special attention and expert assessments are needed before development. Areas where no potential hazard is shown can in practice be developed without further studies, which call for relatively conservative susceptibility maps. However, conservative maps are problematic as they too often increase both cost and duration of building projects beyond the reasonable. 2. Areas where hazard maps or risk mitigation initiatives will be funded are chosen by means of cost-benefits analyses which are often uncertain. How to estimate the benefits if the real probability for damage can only be judged on a very subjective level but not really calculated? As a result, we may use large amounts of money to mitigate the risk for a few houses with a yearly probability of damage of 1/300 and not do anything for an isolated farm with a yearly probability of damage larger than 1/50. 3. Is it ethical to stop the plan to construct a pedestrian and a cycling way or a new road crossing exposed to potential landslide hazard, when the delay or disapproval of the implementation of the plan itself involves a severe consequence than the actual landslide hazard? 4. Most fatalities from natural hazards in Norway happen because of snow avalanches in recreational activities. On the one hand, this suggests that one should use a large share of the annual budget to prevent this type of accident, where there are most lives to spare. On the other hand, one could argue that the voluntary exposure to hazard shouldn't be given too much priority at the expense of buildings and public infrastructures. 5. More generally, how ethical is it to use large amounts of money to manage hazards that has a remote probability to occur or that will not cause human losses or property damage, instead of for example strengthening other social demands?

Radiated Emissions from a Remote-Controlled Airplane-Measured in a Reverberation Chamber

NASA Technical Reports Server (NTRS)

Ely, Jay J.; Koppen, Sandra V.; Nguyen, Truong X.; Dudley, Kenneth L.; Szatkowski, George N.; Quach, Cuong C.; Vazquez, Sixto L.; Mielnik, John J.; Hogge, Edward F.; Hill, Boyd L.;

Exploring Carers' Judgements of Responsibility and Control in Response to the Challenging Behaviour of People with Intellectual Disabilities

ERIC Educational Resources Information Center

Williams, Sophie; Dagnan, Dave; Rodgers, Jacqui; Freeston, Mark

2015-01-01

Background: This study examines Weiner's recent cognitive emotional model which makes a distinction between judgements of control and responsibility and emphasizes the moderation of control by "mitigating" factors. Method: In response to four vignettes describing two conditions of control (high or low) and mitigating factors (present or…

Flood damage in Italy: towards an assessment model of reconstruction costs

NASA Astrophysics Data System (ADS)

Sterlacchini, Simone; Zazzeri, Marco; Genovese, Elisabetta; Modica, Marco; Zoboli, Roberto

2016-04-01

Recent decades in Italy have seen a very rapid expansion of urbanisation in terms of physical assets, while demographics have remained stable. Both the characteristics of Italian soil and anthropic development, along with repeated global climatic stress, have made the country vulnerable to floods, the intensity of which is increasingly alarming. The combination of these trends will contribute to large financial losses due to property damage in the absence of specific mitigation strategies. The present study focuses on the province of Sondrio in Northern Italy (area of about 3,200 km²), which is home to more than 180,000 inhabitants and the population is growing slightly. It is clearly a hot spot for flood exposure, as it is primarily a mountainous area where floods and flash floods hit frequently. The model we use for assessing potential flood damage determines risk scenarios by overlaying flood hazard maps and economic asset data. In Italy, hazard maps are provided by Regional Authorities through the Hydrogeological System Management Plan (PAI) based on EU Flood Directive guidelines. The PAI in the study area includes both the large plain and the secondary river system and considers three hazard scenarios of Low, Medium and High Frequency associated with return periods of 20, 200 and 500 years and related water levels. By an overlay of PAI maps and residential areas, visualized on a GIS, we determine which existing built-up areas are at risk for flood according to each scenario. Then we investigate the value of physical assets potentially affected by floods in terms of market values, using the database of the Italian Property Market Observatory (OMI), and in terms of reconstruction costs, by considering synthetic cost indexes of predominant building types (from census information) and PAI water height. This study illustrates a methodology to assess flood damage in urban settlements and aims to determine general guidelines that can be extended throughout Italy. The final objective will be to analyse how the loss prospective can change when mitigation measures, including actions to reduce the flood hazard and strategies to prevent potential consequences, are implemented. Flood impacts and the corresponding value of mitigation measures will be assessed by means of a cost-benefit analysis in accordance with the EU Floods Directive.

Using Space Technologies for a timely detection of forest fires: the experience of end-users in 3 Italian Regions

NASA Astrophysics Data System (ADS)

Filizzola, Carolina; Belloni, Antonella; Benigno, Giuseppe; Biancardi, Alberto; Corrado, Rosita; Coviello, Irina; De Costanzo, Giovanni; Genzano, Nicola; Lacava, Teodosio; Lisi, Mariano; Marchese, Francesco; Mazzeo, Giuseppe; Merzagora, Cinzio; Paciello, Rossana; Pergola, Nicola; Sannazzaro, Filomena; Serio, Salvatore; Tramutoli, Valerio

2013-04-01

Every year, hundreds of thousands of hectares of European forests are destroyed by fires. Due to the particular topography, landscape and demographic distribution in Europe (very different from typical scenarios of China, USA, Canada and Australia), rapidity in fire sighting is still the determining factor in limiting damages to people and goods. Moreover, the possibility of early fire detection means also potentially to reduce the size of the event to be faced, the necessary fire fighting resources and, therefore, even the reaction times. In such a context, integration of satellite technologies (mainly high temporal resolution data) and traditional surveillance systems within the fire fighting procedures seems to positively impact on the effectiveness of active fire fighting as demonstrated by recent experiences over Italian territory jointly performed by University of Basilicata, IMAA-CNR and Local Authorities. Real time implementation was performed since 2007, during fire seasons, over several Italian regions with different fire regimes and features, in order to assess the actual potential of different satellite-based fire detection products to support regional and local authorities in efficiently fighting fires and better mitigating their negative effects. Real-time campaigns were carried out in strict collaboration with end-users within the framework of specific projects (i.e. the AVVISA, AVVISTA and AVVISA-Basilicata projects) funded by Civil Protection offices of Regione Lombardia, Provincia Regionale di Palermo and Regione Basilicata in charge of fire risk management and mitigation. A tailored training program was dedicated to the personnel of Regional Civil Protection offices in order to ensure the full understanding and the better integration of satellite based products and tools within the existing fire fighting protocols. In this work, outcomes of these practices are shown and discussed, especially highlighting the impact that a real time satellite system may have in assisting and complementing traditional surveillance systems to mitigate damages due to fires. In particular, the usefulness of satellite technology in an operational context was demonstrated mainly in reference to: i) the possibility of identifying fires at an early stage (so avoiding that small hotbeds could extend and become dangerous for citizens and destructive for environmental protected areas) as well as ii) the possibility to have an effective territorial control (e.g. discovering illegal burning fires such as unauthorized cleaning fires, and permitting local authorities to rapidly intervene and catch red-handed pyromaniacs).

Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage.

PubMed

Kim, Seok-Jo; Cheresh, Paul; Jablonski, Renea P; Morales-Nebreda, Luisa; Cheng, Yuan; Hogan, Erin; Yeldandi, Anjana; Chi, Monica; Piseaux, Raul; Ridge, Karen; Michael Hart, C; Chandel, Navdeep; Scott Budinger, G R; Kamp, David W

2016-12-01

Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos exposed lung, the generation of mitochondrial reactive oxygen species (ROS) in AEC mediate mitochondrial DNA (mtDNA) damage and apoptosis which are necessary for lung fibrosis. These data suggest that mitochondrial-targeted antioxidants should ameliorate asbestos-induced lung. To determine whether transgenic mice that express mitochondrial-targeted catalase (MCAT) have reduced lung fibrosis following exposure to asbestos or bleomycin and, if so, whether this occurs in association with reduced AEC mtDNA damage and apoptosis. Crocidolite asbestos (100µg/50µL), TiO 2 (negative control), bleomycin (0.025 units/50µL), or PBS was instilled intratracheally in 8-10 week-old wild-type (WT - C57Bl/6J) or MCAT mice. The lungs were harvested at 21d. Lung fibrosis was quantified by collagen levels (Sircol) and lung fibrosis scores. AEC apoptosis was assessed by cleaved caspase-3 (CC-3)/Surfactant protein C (SFTPC) immunohistochemistry (IHC) and semi-quantitative analysis. AEC (primary AT2 cells from WT and MCAT mice and MLE-12 cells) mtDNA damage was assessed by a quantitative PCR-based assay, apoptosis was assessed by DNA fragmentation, and ROS production was assessed by a Mito-Sox assay. Compared to WT, crocidolite-exposed MCAT mice exhibit reduced pulmonary fibrosis as measured by lung collagen levels and lung fibrosis score. The protective effects in MCAT mice were accompanied by reduced AEC mtDNA damage and apoptosis. Similar findings were noted following bleomycin exposure. Euk-134, a mitochondrial SOD/catalase mimetic, attenuated MLE-12 cell DNA damage and apoptosis. Finally, compared to WT, asbestos-induced MCAT AT2 cell ROS production was reduced. Our finding that MCAT mice have reduced pulmonary fibrosis, AEC mtDNA damage and apoptosis following exposure to asbestos or bleomycin suggests an important role for AEC mitochondrial H 2 O 2 -induced mtDNA damage in promoting lung fibrosis. We reason that strategies aimed at limiting AEC mtDNA damage arising from excess mitochondrial H 2 O 2 production may be a novel therapeutic target for mitigating pulmonary fibrosis. Published by Elsevier Inc.

Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage

PubMed Central

Kim, Seok-Jo; Cheresh, Paul; Jablonski, Renea P.; Morales-Nebreda, Luisa; Cheng, Yuan; Hogan, Erin; Yeldandi, Anjana; Chi, Monica; Piseaux, Raul; Ridge, Karen; Hart, C. Michael; Chandel, Navdeep; Budinger, G.R. Scott; Kamp, David W.

2018-01-01

Rationale Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos exposed lung, the generation of mitochondrial reactive oxygen species (ROS) in AEC mediate mitochondrial DNA (mtDNA) damage and apoptosis which are necessary for lung fibrosis. These data suggest that mitochondrial-targeted antioxidants should ameliorate asbestos-induced lung. Objective To determine whether transgenic mice that express mitochondrial-targeted catalase (MCAT) have reduced lung fibrosis following exposure to asbestos or bleomycin and, if so, whether this occurs in association with reduced AEC mtDNA damage and apoptosis. Methods Crocidolite asbestos (100 μg/50 μL), TiO2 (negative control), bleomycin (0.025 units/50 μL), or PBS was instilled intratracheally in 8–10 week-old wild-type (WT - C57Bl/6 J) or MCAT mice. The lungs were harvested at 21 d. Lung fibrosis was quantified by collagen levels (Sircol) and lung fibrosis scores. AEC apoptosis was assessed by cleaved caspase-3 (CC-3)/Surfactant protein C (SFTPC) immunohistochemistry (IHC) and semi-quantitative analysis. AEC (primary AT2 cells from WT and MCAT mice and MLE-12 cells) mtDNA damage was assessed by a quantitative PCR-based assay, apoptosis was assessed by DNA fragmentation, and ROS production was assessed by a Mito-Sox assay. Results Compared to WT, crocidolite-exposed MCAT mice exhibit reduced pulmonary fibrosis as measured by lung collagen levels and lung fibrosis score. The protective effects in MCAT mice were accompanied by reduced AEC mtDNA damage and apoptosis. Similar findings were noted following bleomycin exposure. Euk-134, a mitochondrial SOD/catalase mimetic, attenuated MLE-12 cell DNA damage and apoptosis. Finally, compared to WT, asbestos-induced MCAT AT2 cell ROS production was reduced. Conclusions Our finding that MCAT mice have reduced pulmonary fibrosis, AEC mtDNA damage and apoptosis following exposure to asbestos or bleomycin suggests an important role for AEC mitochondrial H2O2-induced mtDNA damage in promoting lung fibrosis. We reason that strategies aimed at limiting AEC mtDNA damage arising from excess mitochondrial H2O2 production may be a novel therapeutic target for mitigating pulmonary fibrosis. PMID:27840320