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Sample records for danielsson patrik jansson

  1. Patrik and Putrik and Clown Ferdl; Findings and Cognition on the Television Perception of Children and Young People Based on the Prize-Winning Programmes of Prix Jeunesse 1966. Publications of the Internationales Zentralinstitut fur das Jugend- und Bildungsfernsehen, Number 3.

    ERIC Educational Resources Information Center

    Griebel, Francine, Ed.; Burger, Anette, Ed.

    The results of an investigation of the reactions of young children (ranging from four to nine years of age) in France, Germany, England, America, and Czechoslovkia to two Prix Jeunesse winning television films are examined in this document. Summarized reports from each of the participating countries for the film "Patrik and Putrik" and,…

  2. Using the "Write Talk-nology" with Patrik.

    ERIC Educational Resources Information Center

    Erickson, Karen A.; Koppenhaver, David A.

    1998-01-01

    A case study is presented of an 11-year-old boy with multiple disabilities who uses DynaVox, a voice-output communication device with a touch screen display, in an inclusive classroom. The article discusses how to find the right technology for children with disabilities by evaluating the level of the text, instruction, and classroom. (CR)

  3. The 1988 Jansson memorial lecture. The performance of the 'idiot-savant': implicit and explicit.

    PubMed

    O'Connor, N

    1989-04-01

    'Idiots-savants' are people of low intelligence who have one or two outstanding talents such as calendrical calculation, drawing or musical performance. Such people are mostly male and occur with high frequency among the autistic population. Do they perform their amazing feats because of an outstanding memory or do they draw on some faculty of reasoning to help them? Although they cannot easily make clear how they carry out their tasks by using speech, experiments reveal that they follow simple rules which they use to aid them in recalling correct dates and sequences in classical music. It has been said that they cannot abstract but this turns out not to be true: all can abstract to some degree and some are more at home with abstract than with concrete material. Whatever else is true of these handicapped but gifted people their gift becomes apparent at an early age and is apparently not improved by practice. Perhaps the most important conclusion from work with these groups is that their gifts force us to think again about the concept of general intelligence. How far is it possible to have low intelligence and yet be an outstanding musician or artist? Speculation on this idea may force us to revise our concepts of intelligence, neuropsychology and handicap.

  4. The Historicity of the Physics Class: Enactments, Mimes and Imitation

    ERIC Educational Resources Information Center

    Bergwik, Staffan

    2014-01-01

    This essay discusses Anna Danielsson's article "In the physics class: university physics students' enactments of class and gender in the context of laboratory work". The situated co-construction of knowledge and identity forms the crucial vantage point and I argue that it is a point of intersection between the history of…

  5. Eriosomatine aphids (Hemiptera, Aphididae, Eriosomatinae) associated with moss and roots of conifer and willow in forests of the Pacific Northwest

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Apterous adult morphs of eriosomatine aphids (Hemiptera, Aphididae, Eriosomatinae) associated with moss and/or roots of conifer or willow in forests of the Pacific Northwest including Alaska are described, illustrated, and keyed. In total, seven species (Clydesmithia canadensis Danielsson, Melaphis ...

  6. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    NASA Astrophysics Data System (ADS)

    Suominen, Kalle-Antti

    2010-09-01

    information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

  7. Secrets of the Soil (LBNL Science at the Theater)

    SciTech Connect

    Brodie, Eoin; Northen, Trent; Jansson, Janet; Torn, Margaret

    2011-11-07

    Four Berkeley Lab scientists unveil the "Secrets of the Soil"at this Nov. 7, 2011 Science at the Theater event. Eoin Brodie, Janet Jansson, Margaret Torn and Trent Northen talk about their research and how soil could hold the key to our climate and energy future.The discussion was moderated by John Harte, who holds a joint professorship in the Energy and Resources Group and the Ecosystem Sciences Division of UC Berkeley's College of Natural Resources

  8. LIGA-based microsystem manufacturing:the electrochemistry of through-mold depostion and material properties.

    SciTech Connect

    Kelly, James J. (Sandia National Laboratories, Livermore, CA); Goods, Steven Howard (Sandia National Laboratories, Livermore, CA)

    2005-06-01

    The report presented below is to appear in ''Electrochemistry at the Nanoscale'', Patrik Schmuki, Ed. Springer-Verlag, (ca. 2005). The history of the LIGA process, used for fabricating dimensional precise structures for microsystem applications, is briefly reviewed, as are the basic elements of the technology. The principal focus however, is on the unique aspects of the electrochemistry of LIGA through-mask metal deposition and the generation of the fine and uniform microstructures necessary to ensure proper functionality of LIGA components. We draw from both previously published work by external researchers in the field as well as from published and unpublished studies from within Sandia.

  9. The historicity of the physics class: enactments, mimes and imitation

    NASA Astrophysics Data System (ADS)

    Bergwik, Staffan

    2014-06-01

    This essay discusses Anna Danielsson's article "In the physics class: university physics students' enactments of class and gender in the context of laboratory work". The situated co-construction of knowledge and identity forms the crucial vantage point and I argue that it is a point of intersection between the history of science and research in science education. The former can provide a valuable understanding of the historicity of learning science. I thus highlight the importance of knowledge as situated in time and space, for instance the importance of the historical division between "head and hand" clearly visible in the discourse of Danielsson's informants. Moreover, the article discusses how identity is produced in specific knowledge contexts through repeated performances. The article closes by briefly suggesting analytical alternatives, in particular "belonging" and "imitation". Both draw on post-structuralist ideas about the citational nature of identity. Belonging is created by citing and reinstating norms. Imitating knowledge, identity and norms is an issue that should be brought to the fore when we speak of education and training.

  10. The historicity of the physics class: enactments, mimes and imitation

    NASA Astrophysics Data System (ADS)

    Bergwik, Staffan

    2013-04-01

    This essay discusses Anna Danielsson's article "In the physics class: university physics students' enactments of class and gender in the context of laboratory work". The situated co-construction of knowledge and identity forms the crucial vantage point and I argue that it is a point of intersection between the history of science and research in science education. The former can provide a valuable understanding of the historicity of learning science. I thus highlight the importance of knowledge as situated in time and space, for instance the importance of the historical division between "head and hand" clearly visible in the discourse of Danielsson's informants. Moreover, the article discusses how identity is produced in specific knowledge contexts through repeated performances. The article closes by briefly suggesting analytical alternatives, in particular "belonging" and "imitation". Both draw on post-structuralist ideas about the citational nature of identity. Belonging is created by citing and reinstating norms. Imitating knowledge, identity and norms is an issue that should be brought to the fore when we speak of education and training.

  11. Modified SNOW 3G: Stream cipher algorithm using piecewise linear chaotic map

    NASA Astrophysics Data System (ADS)

    Wasi, Muhammad Arif Ali; Windarta, Susila

    2016-02-01

    SNOW 3G is a synchronous stream cipher developed by Thomas Johansson and Patrik Ekhdal at Lund University. In 2006, it was chosen as the main part of the second set of Universal Mobile Telecommunications System (UMTS) confidentiality and integrity algorithms [2]. In 2008, Patrik Böhm published a report entitled "Statistical Evaluation of Stream Cipher SNOW 3G". He tested the randomness properties of SNOW 3G key stream generator. Böhm using NIST statistical test suite as randomness test tool with three kinds of test, i.e. long key stream data set, short key stream data set, and initialization vector data set. The result of the report shows that from three kind of tests, only short key stream data set has not passed eight randomness tests. He state that the suggests SNOW 3G fail because there is a weakness in the initialization of the cipher. In this paper we modify SNOW 3G algorithm using piecewise linear chaotic map (PLCM) on the key initialization mode and keystream generation mode. We use the same statistical test that have been used by Böhm [5]. The experiment shows that modified SNOW 3G stream cipher algorithm has passed all the statistical test. The results prove that PLCM impact on algorithm's randomness.

  12. Terragenome: International Soil Metagenome Sequencing Consortium (GSC8 Meeting)

    ScienceCinema

    Jansson, Janet [LBNL

    2016-07-12

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Janet Jansson of the Lawrence Berkeley National Laboratory discusses the Terragenome Initiative at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009

  13. Sensitivity study and uncertainties assessment of the permafrost model for the Swiss Alps

    NASA Astrophysics Data System (ADS)

    Marmy, Antoine; Hauck, Christian; Scherler, Martin

    2013-04-01

    Modeling the evolution and the sensitivity of permafrost in the European Alps in the context of climate change is one of the most relevant and challenging task of the permafrost research in progress. The one dimensional soil-snow-atmosphere model CoupModel (Jansson & Karlberg 2001) has already been applied successfully for permafrost modeling in the Swiss Alps (Engelhardt et al. 2010, Scherler et al. 2010). Two sites in the Swiss Alps have been studied with a particular focus: the active rock glacier Murtèl (Upper Engadine), and the Schilthorn massif (Bernese Alps). In order to evaluate the sensitivity of the model to changes in air temperature and precipitations, a sensitivity study of the model has been carried out using a delta change approach. Annual and seasonal deltas were applied to air temperature and precipitation input series until the end of the century using a large parameter range in equidistant steps. The resulting ground thermal regimes and active layer thicknesses of rock glacier Murtèl and the Schilthorn massif are analysed and presented in this contribution. In addition, the General Likelihood Uncertainty Estimation (GLUE) method is used to assess the uncertainty of the simulations within the CoupModel (Jansson 2012). This method is based on an unbiased sampling of parameter values during simulation considering all combination of prescribed parameter values, such as thermal conductivities or snow parameters. Statistical performance indicators as Root Mean Square Error or Coefficient of Determination are used to define the acceptance of values and to assess the uncertainty. By this, not only the most appropriate parameter values for consistent subsurface modeling for the two permafrost sites can be determined, but model-based uncertainty ranges of the resulting ground temperatures and active layer thicknesses can be estimated. References: Engelhardt, M., Hauck, C., and Salzmann, N. (2010) Influence of atmospheric forcing parameters on modelled

  14. Minimal cutoff vacuum state constraints from CMB bispectrum statistics

    SciTech Connect

    Meerburg, P. Daniel; Schaar, Jan Pieter van der

    2011-02-15

    In this short note we translate the best available observational bounds on the CMB bispectrum amplitudes into constraints on a specific scale-invariant new physics hypersurface model of vacuum state modifications, as first proposed by Danielsson, in general models of single-field inflation. As compared to the power spectrum the bispectrum constraints are less ambiguous and provide an interesting upper bound on the cutoff scale in general models of single-field inflation with a small speed of sound. This upper bound is incompatible with the power spectrum constraint for most of the parameter domain, leaving very little room for minimal cutoff vacuum state modifications in general single-field models with a small speed of sound.

  15. Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

    PubMed

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

  16. Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches

    PubMed Central

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A.; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available. PMID:25569628

  17. Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

    PubMed

    Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A; Lundström, Patrik

    2015-01-01

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available. PMID:25569628

  18. Handling data redundancy in helical cone beam reconstruction with a cone-angle-based window function and its asymptotic approximation

    SciTech Connect

    Tang Xiangyang; Hsieh Jiang

    2007-06-15

    A cone-angle-based window function is defined in this manuscript for image reconstruction using helical cone beam filtered backprojection (CB-FBP) algorithms. Rather than defining the window boundaries in a two-dimensional detector acquiring projection data for computed tomographic imaging, the cone-angle-based window function deals with data redundancy by selecting rays with the smallest cone angle relative to the reconstruction plane. To be computationally efficient, an asymptotic approximation of the cone-angle-based window function is also given and analyzed in this paper. The benefit of using such an asymptotic approximation also includes the avoidance of functional discontinuities that cause artifacts in reconstructed tomographic images. The cone-angle-based window function and its asymptotic approximation provide a way, equivalent to the Tam-Danielsson-window, for helical CB-FBP reconstruction algorithms to deal with data redundancy, regardless of where the helical pitch is constant or dynamically variable during a scan. By taking the cone-parallel geometry as an example, a computer simulation study is conducted to evaluate the proposed window function and its asymptotic approximation for helical CB-FBP reconstruction algorithm to handle data redundancy. The computer simulated Forbild head and thorax phantoms are utilized in the performance evaluation, showing that the proposed cone-angle-based window function and its asymptotic approximation can deal with data redundancy very well in cone beam image reconstruction from projection data acquired along helical source trajectories. Moreover, a numerical study carried out in this paper reveals that the proposed cone-angle-based window function is actually equivalent to the Tam-Danielsson-window, and rigorous mathematical proofs are being investigated.

  19. Modal analysis of violin bodies viewed as three-dimensional structures

    NASA Astrophysics Data System (ADS)

    Rossing, Thomas D.; Molin, Nils-Erik; Runnemalm, Anna

    2003-10-01

    Modal analyses of violins show several strong modes in the low frequency range. Holographic interferograms suggest that four strong modes can be interpreted as doublets having two and three nodal planes that intersect a cylinder with a roughly elliptical cross section at the bridge [A. Runnemalm, N.-E. Molin, and E. Jansson, J. Acoust. Soc. Am. 107, 3452-3459 (2000); M. Roberts and T. D. Rossing, Catgut Acoust. Soc. J. 3, 9-15 (1998)]. This is especially clear when the instrument is viewed simultaneously from three sides using mirrors, and the holographic system is made sensitive to in-plane motion as well. These doublets are not unlike those observed in cylindrical vibrators such as bells, and they remind us that a violin is a 3-dimensional object.

  20. Iterative smoothing and deconvolution of one- and two-dimensional elemental distribution data

    NASA Astrophysics Data System (ADS)

    Coote, G. E.

    1997-07-01

    The resolution of the data from many instruments can be improved, or the rate of data collection can be increased for the same final resolution, by applying to the data reliable algorithms for smoothing and deconvolution. Iterative methods which were formerly impractical can easily be applied on a small computer. An ingenious linear algorithm for deconvolution of one-dimensional data (van Cittert, 1931) gave much better results when Jansson (1963) introduced a relaxation function which ensured the results remained positive. Gold (1964) derived by a matrix approach a nonlinear algorithm which used a different method of comparison, but Xu et al. showed 30 years later that it is a special van Cittert algorithm with a variable relaxation function. Tests of Gold's method show that it is reliable and much faster than Jansson's algorithm, converging in 20 iterations or fewer. If a microprobe beam spot is to a good approximation square or rectangular a 2-D image can be smoothed or deconvolved in the X and Y directions independently, and the Gold algorithm has proved suitable for the deconvolution stage. Almost all smoothing methods will broaden narrow peaks, but an exception is the linear iterative method of Morrison (1962), which reduces any structure narrower than the resolution function. The negative feedback step used in the deconvolution algorithms is not possible in a smoothing algorithm. The method suffers from a halting problem, since it smoothes during early iterations but eventually reproduces the original data. This can be prevented by introducing a relaxation function which is unity for the first iteration but decreases rapidly with succeeding iterations.

  1. The effect of temporal variability of soil moisture on mountain permafrost: a combined model and monitoring approach

    NASA Astrophysics Data System (ADS)

    Pellet, Cécile; Hauck, Christian; Stähli, Manfred

    2016-04-01

    Soil moisture is a key factor controlling the energy and mass exchange processes at the soil-atmosphere interface. In permanently frozen ground it strongly affects the thermal behaviour of the ground by influencing its physical properties such as ice content, thermal conductivity and heat capacity. It also influences other processes like evaporation, infiltration, refreezing rate and runoff and modifies the electrical and electromagnetic properties such as electrical conductivity and permittivity that are used in indirect geophysical and remote sensing methods. In a first attempt to quantify the role of water content, a soil moisture network along an altitudinal gradient in middle and high mountain areas in Switzerland has been initiated, and first results confirm the importance of different water related processes that are dominant at different elevation bands. At very high elevations, in permafrost regions, these processes have not yet been analysed in detail, and current state-of-the-art climate and climate impact simulations are neither calibrated nor validated regarding water content in the subsurface, mostly due to missing data. Using the data from the new soil moisture network in combination with measured in-situ ground temperatures and meteorological parameters (air temperature, global radiation, and wind speed), we calibrated the one dimensional heat and mass transfer model COUP (Jansson, 2012) at all locations. This model was then used to analyse the water balance and more precisely the specific repartition of precipitations into runoff, evaporation and change in moisture content. Finally, we analysed the relations between infiltrating water from the snow cover, phase changes and latent heat release and its influence on subsurface temperature in frozen terrains. REFERENCES Jansson, P.-E. 2012: Coupmodel: Model Use, Calibration and Validation, Transaction of the Asabe, 55(4), 1335-1344.

  2. `You Have to Give Them Some Science Facts': Primary Student Teachers' Early Negotiations of Teacher Identities in the Intersections of Discourses About Science Teaching and About Primary Teaching

    NASA Astrophysics Data System (ADS)

    Danielsson, Anna T.; Warwick, Paul

    2014-04-01

    In the broadest sense, the goal for primary science teacher education could be described as preparing these teachers to teach for scientific literacy. Our starting point is that making such science teaching accessible and desirable for future primary science teachers is dependent not only on their science knowledge and self-confidence, but also on a whole range of interrelated sociocultural factors. This paper aims to explore how intersections between different Discourses about primary teaching and about science teaching are evidenced in primary school student teachers' talk about becoming teachers. The study is founded in a conceptualisation of learning as a process of social participation. The conceptual framework is crafted around two key concepts: Discourse (Gee 2005) and identity (Paechter, Women's Studies International Forum, 26(1):69-77, 2007). Empirically, the paper utilises semi-structured interviews with 11 primary student teachers enrolled in a 1-year Postgraduate Certificate of Education course. The analysis draws on five previously identified teacher Discourses: `Teaching science through inquiry', `Traditional science teacher', `Traditional primary teacher', `Teacher as classroom authority', and `Primary teacher as a role model' (Danielsson and Warwick, International Journal of Science Education, 2013). It explores how the student teachers, at an early stage in their course, are starting to intersect these Discourses to negotiate their emerging identities as primary science teachers.

  3. World Sheet Commuting beta-gamma CFT and Non-Relativistic StringTheories

    SciTech Connect

    Kim, Bom Soo

    2007-08-30

    We construct a sigma model in two dimensions with Galilean symmetry in flat target space similar to the sigma model of the critical string theory with Lorentz symmetry in 10 flat spacetime dimensions. This is motivated by the works of Gomis and Ooguri[1] and Danielsson et. al.[2, 3]. Our theory is much simpler than their theory and does not assume a compact coordinate. This non-relativistic string theory has a bosonic matter {beta}{gamma} CFT with the conformal weight of {beta} as 1. It is natural to identify time as a linear combination of {gamma} and {bar {gamma}} through an explicit realization of the Galilean boost symmetry. The angle between {gamma} and {bar {gamma}} parametrizes one parameter family of selection sectors. These selection sectors are responsible for having a non-relativistic dispersion relation without a nontrivial topology in the non-relativistic setup, which is one of the major differences from the previous works[1, 2, 3]. This simple theory is the non-relativistic analogue of the critical string theory, and there are many different avenues ahead to be investigated. We mention a possible consistent generalization of this theory with different conformal weights for the {beta}{gamma} CFT. We also mention supersymmetric generalizations of these theories.

  4. Multi-sheet surface rebinning methods for reconstruction from asymmetrically truncated cone beam projections: I. Approximation and optimality

    NASA Astrophysics Data System (ADS)

    Betcke, Marta M.; Lionheart, William R. B.

    2013-11-01

    The mechanical motion of the gantry in conventional cone beam CT scanners restricts the speed of data acquisition in applications with near real time requirements. A possible resolution of this problem is to replace the moving source detector assembly with static parts that are electronically activated. An example of such a system is the Rapiscan Systems RTT80 real time tomography scanner, with a static ring of sources and axially offset static cylinder of detectors. A consequence of such a design is asymmetrical axial truncation of the cone beam projections resulting, in the sense of integral geometry, in severely incomplete data. In particular we collect data only in a fraction of the Tam-Danielsson window, hence the standard cone beam reconstruction techniques do not apply. In this work we propose a family of multi-sheet surface rebinning methods for reconstruction from such truncated projections. The proposed methods combine analytical and numerical ideas utilizing linearity of the ray transform to reconstruct data on multi-sheet surfaces, from which the volumetric image is obtained through deconvolution. In this first paper in the series, we discuss the rebinning to multi-sheet surfaces. In particular we concentrate on the underlying transforms on multi-sheet surfaces and their approximation with data collected by offset multi-source scanning geometries like the RTT. The optimal multi-sheet surface and the corresponding rebinning function are found as a solution of a variational problem. In the case of the quadratic objective, the variational problem for the optimal rebinning pair can be solved by a globally convergent iteration. Examples of optimal rebinning pairs are computed for different trajectories. We formulate the axial deconvolution problem for the recovery of the volumetric image from the reconstructions on multi-sheet surfaces. Efficient and stable solution of the deconvolution problem is the subject of the second paper in this series (Betcke and

  5. Rotating polygon instability of a swirling free surface flow.

    PubMed

    Tophøj, L; Mougel, J; Bohr, T; Fabre, D

    2013-05-10

    We explain the rotating polygon instability on a swirling fluid surface [G. H. Vatistas, J. Fluid Mech. 217, 241 (1990) and Jansson et al., Phys. Rev. Lett. 96, 174502 (2006)] in terms of resonant interactions between gravity waves on the outer part of the surface and centrifugal waves on the inner part. Our model is based on potential flow theory, linearized around a potential vortex flow with a free surface for which we show that unstable resonant states appear. Limiting our attention to the lowest order mode of each type of wave and their interaction, we obtain an analytically soluble model, which, together with estimates of the circulation based on angular momentum balance, reproduces the main features of the experimental phase diagram. The generality of our arguments implies that the instability should not be limited to flows with a rotating bottom (implying singular behavior near the corners), and indeed we show that we can obtain the polygons transiently by violently stirring liquid nitrogen in a hot container.

  6. Estimation of extreme precipitation; Return period values and PMP for Norway

    NASA Astrophysics Data System (ADS)

    Engen-Skaugen, Torill; Alfnes, Eli; Førland, Eirik J.

    2010-05-01

    Estimates of extreme values of precipitation represented as return period values and Probable Maximum Precipitation (PMP) are frequently used in flood evaluation as well as dimensioning of hydro power dams. The estimates are also of interest for infrastructure constructions (e.g. urban runoff). The estimates establish a reference to how rare a heavy rainfall event at a location is. This study presents present-day and future return period values and PMP estimates for several catchments in Norway. Daily precipitation values are extracted from grids covering the Norwegian mainland, spatial resolution 1 x 1 km2, for the time period 1957 - 2009. The grids are interpolated from observations at all available rain gage stations operated by the Norwegian Meteorolgoical Institute in Norway. The maps can be seen at http://senorge.no (Mohr, 2009; Jansson et al., 2007). The rain gauge network in the high mountain region is sparse, leading to reduced quality in these regions. A rough correction of daily gauge precipitation for undercatch because of wind exposure is performed before interpolation. Six climate projections downscaled with different Regional Climate Models (RCMs) are adjusted to be representative locally for the Norwegian mainland (Engen-Skaugen, 2007). Daily precipitation projections are established for the same grid extent as for observations. Time series of daily precipitation are then extracted from these grids representing the same catchments as the historic data. The estimates of extreme precipitation are based on daily precipitation values (Førland, 1992; Alfnes, 2007). Instead of producing area estimates based on site values adjusted by an Area Reduction Factor (ARF), area estimates in the present study is based on time series of daily precipitation representing the actual catchments extracted from the high resolution grids. Alfnes (2007) found that the five-year return value estimates (M5) for these two methods were similar, with exceptions for catchments

  7. The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice

    PubMed Central

    Fagman, Johan B.; Wilhelmson, Anna S.; Motta, Benedetta M.; Pirazzi, Carlo; Alexanderson, Camilla; De Gendt, Karel; Verhoeven, Guido; Holmäng, Agneta; Anesten, Fredrik; Jansson, John-Olov; Levin, Malin; Borén, Jan; Ohlsson, Claes; Krettek, Alexandra; Romeo, Stefano; Tivesten, Åsa

    2015-01-01

    Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)–dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein E (apoE)–deficient background. After 8 weeks on a high-fat diet, but not on a normal chow diet, atherosclerosis in aorta was increased in ARKO females (+59% vs. control apoE-deficient mice with intact AR gene). They also displayed increased body weight (+18%), body fat percentage (+62%), and hepatic triglyceride levels, reduced insulin sensitivity, and a marked atherogenic dyslipidemia (serum cholesterol, +52%). Differences in atherosclerosis, body weight, and lipid levels between ARKO and control mice were abolished in mice that were ovariectomized before puberty, consistent with a protective action of ovarian androgens mediated via the AR. Furthermore, the AR agonist dihydrotestosterone reduced atherosclerosis (−41%; thoracic aorta), subcutaneous fat mass (−44%), and cholesterol levels (−35%) in ovariectomized mice, reduced hepatocyte lipid accumulation in hepatoma cells in vitro, and regulated mRNA expression of hepatic genes pivotal for lipid homeostasis. In conclusion, we demonstrate that the AR protects against diet-induced atherosclerosis in female mice and propose that this is mediated by modulation of body composition and lipid metabolism.—Fagman, J. B., Wilhelmson, A. S., Motta, B. M., Pirazzi, C., Alexanderson, C., De Gendt, K., Verhoeven, G., Holmäng, A., Anesten, F., Jansson, J.-O., Levin, M., Borén, J., Ohlsson, C., Krettek, A., Romeo, S., Tivesten, A. The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice. PMID:25550469

  8. Changes in thyroid parameters of hatchling American kestrels (Falco sparverius) following embryonic exposure to technical short chain chlorinated paraffins (SCCPs; C10-13, 55.5% CL)

    USGS Publications Warehouse

    Fernie, Kimberly J; Henry, Paula F.; Letcher, Robert J; Palace, Vince; Peters, Lisa; Rattner, Barnett A.; Sverko, Edward; Karouna, Natalie

    2015-01-01

    Chlorinated paraffins (CPs) are complex mixtures of polychlorinated n-alkanes categorized according to their carbon chain length: short chain (SCCPs, C10 – C13), medium (C14 - C17), and long chain (C>17), chlorinated paraffins. SCCPs are primarily used in metalworking applications, as flame retardants, and in paints, adhesives, sealants, textiles, plastics and rubber (UNEP 2012). In 2012, the United Nations Environment Program (UNEP 2012) reported in the Revised Draft Risk Profile for SCCPs, that CPs were produced in the United States, the European Union (EU), Slovakia, Brazil, India, Japan and China. While annual global consumption of SCCPs is large (>25 tonnes/year), it has sharply declined over the past 20 years. SCCPs are released through wastewater, landfills, and air emissions (UNEP 2012). Concentrations of SCCPs have been reported in fish and marine mammals in North and South America, Europe, Japan, Greenland and the Arctic (UNEP 2012 and references therein). Characterization of SCCP concentrations and exposure in terrestrial wildlife is limited. In 2010, SCCP concentrations were reported in the eggs of yellow-legged gulls (Larus michahellis) (4536 ± 40 pg/g wet weight (ww)) and Audouin’s gulls (Larus audouinii) (6364 ± 20 pg/g ww) in Spain (Morales et al. 2012), and little auks (Alle alle) (5 - 88 ng/g ww) and kittiwakes (Rissa tridactyla) (5 - 44 ng/g ww) in the European Arctic (Reth et al. 2006). In Sweden, muscle of ospreys contained CPs of unspecified chain length (Jansson et al. 1993). Although the toxicity of SCCPs has been demonstrated in aquatic invertebrates, fish, frogs, and laboratory rats, there are limited avian studies and these reported no effects of SCCPs on egg parameters of domestic hens (Gallus gallus domesticus) and ducks (Anas platyrhynchos) (UNEP 2012). Despite reported accumulation of SCCPs in wild birds, to our knowledge, exposure-related toxicities and effects with respect to avian wildlife remain unknown.

  9. The Galactic magnetic field and some of its unexpected implications

    NASA Astrophysics Data System (ADS)

    Farrar, Glennys R.

    2015-01-01

    Our understanding of the Galactic magnetic field (GMF) has improved considerably in recent years, although it remains far from adequate. The Jansson-Farrar (2012) (JF12) GMF model is the most realistic and comprehensive model available, having been constrained by fitting all-sky Faraday Rotation Measures of extragalactic sources simultaneously with WMAP polarized (Q,U) and total synchrotron emission maps - a total of more than 10,000 datapoints, each with measured variances. In addition to disk and toroidal halo components, a coherent poloidal field can be shown to be necessary. Moreover a 'striated' random component is needed in addition to a fully random component, in both disk and halo.The out-of-plane (poloidal) field provides a heretofore-overlooked escape route for CRs by anisotropic diffusion along its field lines, drastically modifying CR transport. The spatial distribution and energy spectrum of Galactic cosmic rays enters into constraining the GMF with synchrotron data, predicting astrophysical backgrounds to dark matter annihilation signals, and understanding the WMAP-Fermi-Planck "bubble" emanating from the Galactic center. Having a good model of the Galactic magnetic field is crucial for determining the sources of UHECRs and for modeling synchrotron emission (especially the spatial variation of the spectral index) to accurately subtract foreground to CMB signals essential to see the effects of primordial gravity waves. Given a 3D dust map, the structure of the polarized dust emission can potentially be estimated.In this talk, I will focus on 3 recent developments: establishing the robust features of the global structure of the coherent field, determining how the GMF lenses UHECRs with charges as high as Z=26, and constraining models for composition and origin of CRs above 100 PeV (the Galactic-extragalactic CR transition by) by anisotropy constraints. Preliminary results of efforts to simultaneously constrain the GMF and the Galactic cosmic ray

  10. Philosophy and concepts of modern spine surgery.

    PubMed

    José-Antonio, Soriano-Sánchez; Baabor-Aqueveque, Marcos; Silva-Morales, Francisco

    2011-01-01

    The main goal of improving pain and neurological deficit in the practice of spine surgery is changing for a more ambitious goal, namely to improve the overall quality of life and the future of patients through three major actions (1) preserving the vertebral anatomical structures; (2) preserving the paravertebral anatomical structures; and (3) preserving the functionality of the segment. Thus, three new concepts have emerged (a) minimal surgery; (b) minimal access surgery; and (c) motion preservation surgery. These concepts are covered in a new term, minimally invasive spine surgery (MISS) The term "MISS" is not about one or several particular surgical techniques, but a new way of thinking, a new philosophy. Although the development of minimally invasive spine surgery is recent, its application includes all spine segments and almost all the existing conditions, including deformities.Evidence-based medicine (EBM), a term coined by Alvan Feinstein in the 1960s (Feinstein A (1964) Annals of Internal Medicine 61: 564-579; Feinstein A (1964) Annals of Internal Medicine 61: 757-781; Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), emphasizes the possibility of combining art and science following the strict application of scientific methods in the treatment of patients (Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), which may represent the advantages of objectivity and rationality in the use of different treatments (Fig. 11). However, EBM has many obvious defects, especially in spine surgery it is almost impossible to develop double-blind protocols (Andersson G, Bridwell K, Danielsson A, et al (2007) Spine 32: S64-S65.). In most cases, the only evidence one can find in the literature is the lack of evidence (Resnick D (2007) Spine 32:S15-S19.), however, the lack of evidence does not mean its absence. Only then, with a

  11. PREFACE: Lectures from the European RTN Winter School on Strings, Supergravity and Gauge Fields, Barcelona, 12-16 January 2004

    NASA Astrophysics Data System (ADS)

    Russo, Jorge G.

    2005-04-01

    This issue of Classical and Quantum Gravity contains the proceedings of the RTN European Winter School on Strings, Supergravity and Gauge Fields, which was held at the University of Barcelona, Spain, between 12-16 January 2004. The School was part of the RTN programme The Quantum Structure of Spacetime and the Geometric Nature of Fundamental Interactions of the European Union. It was attended by 181 registered participants. The lectures contain a pedagogical introduction to topics in string theory which are currently under active investigation. They were targeted mainly at students near the end of their PhD, and young postdocs and researchers. The topics were carefully selected to cover phenomenological aspects of string theory, covered by the lectures by A Uranga (Intersecting Brane Worlds) and U Danielsson (String Theory and Cosmology), as well as more fundamental and theoretical issues, covered by N Nekrasov (Non-perturbative Aspects of Supersymmetric Gauge Theories), P Townsend (Branes in Field Theory, not included in these proceedings) and Jaume Gomis (Tachyon Condensation: Towards Time Dependent Backgrounds and Holography). We must thank the lecturers for their admirable exposition of these interesting subjects. We hope that the readers of these proceedings receive these lectures with the same enthusiasm as they were received by all students and physicists that attended the School. Following the tradition of the RTN schools there were, in addition to the lectures, five workgroups on more specialized subjects, which aimed to discuss scientific problems of general interest to our network, facilitate communication between the various groups and, hopefully, help start new collaborations. They were Integrable Structures of the Gauge/String Correspondence led by G Arutyunov and B Stefanski Closed Timelike Curves in Supergravity and String Theory led by N Drukker and L Maoz Black Objects in Higher Dimensional General Relativity and Supergravity led by H Elvang and T

  12. Philosophy and concepts of modern spine surgery.

    PubMed

    José-Antonio, Soriano-Sánchez; Baabor-Aqueveque, Marcos; Silva-Morales, Francisco

    2011-01-01

    The main goal of improving pain and neurological deficit in the practice of spine surgery is changing for a more ambitious goal, namely to improve the overall quality of life and the future of patients through three major actions (1) preserving the vertebral anatomical structures; (2) preserving the paravertebral anatomical structures; and (3) preserving the functionality of the segment. Thus, three new concepts have emerged (a) minimal surgery; (b) minimal access surgery; and (c) motion preservation surgery. These concepts are covered in a new term, minimally invasive spine surgery (MISS) The term "MISS" is not about one or several particular surgical techniques, but a new way of thinking, a new philosophy. Although the development of minimally invasive spine surgery is recent, its application includes all spine segments and almost all the existing conditions, including deformities.Evidence-based medicine (EBM), a term coined by Alvan Feinstein in the 1960s (Feinstein A (1964) Annals of Internal Medicine 61: 564-579; Feinstein A (1964) Annals of Internal Medicine 61: 757-781; Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), emphasizes the possibility of combining art and science following the strict application of scientific methods in the treatment of patients (Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), which may represent the advantages of objectivity and rationality in the use of different treatments (Fig. 11). However, EBM has many obvious defects, especially in spine surgery it is almost impossible to develop double-blind protocols (Andersson G, Bridwell K, Danielsson A, et al (2007) Spine 32: S64-S65.). In most cases, the only evidence one can find in the literature is the lack of evidence (Resnick D (2007) Spine 32:S15-S19.), however, the lack of evidence does not mean its absence. Only then, with a

  13. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients.

    PubMed

    Karaiskos, Ilias; Friberg, Lena E; Pontikis, Konstantinos; Ioannidis, Konstantinos; Tsagkari, Vasiliki; Galani, Lamprini; Kostakou, Eirini; Baziaka, Fotini; Paskalis, Charalambos; Koutsoukou, Antonia; Giamarellou, Helen

    2015-12-01

    Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430-3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241- 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284-3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼ 270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups, while

  14. New constraints on modelling the random magnetic field of the MW

    NASA Astrophysics Data System (ADS)

    Beck, Marcus C.; Beck, Alexander M.; Beck, Rainer; Dolag, Klaus; Strong, Andrew W.; Nielaba, Peter

    2016-05-01

    We extend the description of the isotropic and anisotropic random component of the small-scale magnetic field within the existing magnetic field model of the Milky Way from Jansson & Farrar, by including random realizations of the small-scale component. Using a magnetic-field power spectrum with Gaussian random fields, the NE2001 model for the thermal electrons and the Galactic cosmic-ray electron distribution from the current GALPROP model we derive full-sky maps for the total and polarized synchrotron intensity as well as the Faraday rotation-measure distribution. While previous work assumed that small-scale fluctuations average out along the line-of-sight or which only computed ensemble averages of random fields, we show that these fluctuations need to be carefully taken into account. Comparing with observational data we obtain not only good agreement with 408 MHz total and WMAP7 22 GHz polarized intensity emission maps, but also an improved agreement with Galactic foreground rotation-measure maps and power spectra, whose amplitude and shape strongly depend on the parameters of the random field. We demonstrate that a correlation length of 0≈22 pc (05 pc being a 5σ lower limit) is needed to match the slope of the observed power spectrum of Galactic foreground rotation-measure maps. Using multiple realizations allows us also to infer errors on individual observables. We find that previously-used amplitudes for random and anisotropic random magnetic field components need to be rescaled by factors of ≈0.3 and 0.6 to account for the new small-scale contributions. Our model predicts a rotation measure of -2.8±7.1 rad/m2 and 04.4±11. rad/m2 for the north and south Galactic poles respectively, in good agreement with observations. Applying our model to deflections of ultra-high-energy cosmic rays we infer a mean deflection of ≈3.5±1.1 degree for 60 EeV protons arriving from CenA.

  15. Bioreactors for Tissue Engineering of Cartilage

    NASA Astrophysics Data System (ADS)

    Concaro, S.; Gustavson, F.; Gatenholm, P.

    The cartilage regenerative medicine field has evolved during the last decades. The first-generation technology, autologous chondrocyte transplantation (ACT) involved the transplantation of in vitro expanded chondrocytes to cartilage defects. The second generation involves the seeding of chondrocytes in a three-dimensional scaffold. The technique has several potential advantages such as the ability of arthroscopic implantation, in vitro pre-differentiation of cells and implant stability among others (Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L, N Engl J Med 331(14):889-895, 1994; Henderson I, Francisco R, Oakes B, Cameron J, Knee 12(3):209-216, 2005; Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A, Clin Orthop (374):212-234, 2000; Nagel-Heyer S, Goepfert C, Feyerabend F, Petersen JP, Adamietz P, Meenen NM, et al. Bioprocess Biosyst Eng 27(4):273-280, 2005; Portner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, J Biosci Bioeng 100(3):235-245, 2005; Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, Portner R, J Biotechnol 121(4):486-497, 2006; Heyland J, Wiegandt K, Goepfert C, Nagel-Heyer S, Ilinich E, Schumacher U, et al. Biotechnol Lett 28(20):1641-1648, 2006). The nutritional requirements of cells that are synthesizing extra-cellular matrix increase along the differentiation process. The mass transfer must be increased according to the tissue properties. Bioreactors represent an attractive tool to accelerate the biochemical and mechanical properties of the engineered tissues providing adequate mass transfer and physical stimuli. Different reactor systems have been [5] developed during the last decades based on different physical stimulation concepts. Static and dynamic compression, confined and nonconfined compression-based reactors have been described in this review. Perfusion systems represent an attractive way of culturing constructs under dynamic conditions. Several groups showed increased matrix

  16. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients

    PubMed Central

    Friberg, Lena E.; Pontikis, Konstantinos; Ioannidis, Konstantinos; Tsagkari, Vasiliki; Galani, Lamprini; Kostakou, Eirini; Baziaka, Fotini; Paskalis, Charalambos; Koutsoukou, Antonia; Giamarellou, Helen

    2015-01-01

    Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430–3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241– 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284–3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups

  17. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients.

    PubMed

    Karaiskos, Ilias; Friberg, Lena E; Pontikis, Konstantinos; Ioannidis, Konstantinos; Tsagkari, Vasiliki; Galani, Lamprini; Kostakou, Eirini; Baziaka, Fotini; Paskalis, Charalambos; Koutsoukou, Antonia; Giamarellou, Helen

    2015-12-01

    Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430-3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241- 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284-3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼ 270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups, while

  18. Lipids and Molecular Tools as Biomarkers in Monitoring Air Sparging Bioremediation Processes

    NASA Astrophysics Data System (ADS)

    Heipieper, Hermann J.; Fischer, Janett

    2010-05-01

    .J., Junca H. (2009) Enhancement of the microbial community biomass and diversity during air sparging bioremediation of a Northern Bohemia soil highly contaminated with kerosene and BTEX. Appl. Microbiol. Biotechnol. 82:565-577. Heipieper H.J. (2009) Isolation and analysis of lipids, biomarkers. In: Timmis K.N. (Ed.) Handbook of Hydrocarbon and Lipid Microbiology. Springer, Berlin. Vol. 5, Part 2, pp. 3743-3750. Unell M., Kabelitz N., Jansson J.K., Heipieper H.J. (2007) Adaptation of the psychrotroph Arthrobacter chlorophenolicus A6 to growth temperature and the presence of phenols by changes in the anteiso/iso ratio of branched fatty acids. FEMS Microbiol. Lett. 266 : 138-143.

  19. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo

    PubMed Central

    Kats, Anna; Båge, Tove; Georgsson, Pierre; Jönsson, Jörgen; Quezada, Hernán Concha; Gustafsson, Anders; Jansson, Leif; Lindberg, Claes; Näsström, Karin; Yucel-Lindberg, Tülay

    2013-01-01

    The potent inflammatory mediator prostaglandin E2 (PGE2) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. To identify mPGES-1 inhibitors, we investigated the effect of aminothiazoles on inflammation-induced PGE2 synthesis in vitro, using human gingival fibroblasts stimulated with the cytokine IL-1β and a cell-free mPGES-1 activity assay, as well as on inflammation-induced bone resorption in vivo, using ligature-induced experimental periodontitis in Sprague-Dawley rats. Aminothiazoles 4-([4-(2-naphthyl)-1,3-thiazol-2-yl]amino)phenol (TH-848) and 4-(3-fluoro-4-methoxyphenyl)-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine (TH-644) reduced IL-1β-induced PGE2 production in fibroblasts (IC50 1.1 and 1.5 μM, respectively) as well as recombinant mPGES-1 activity, without affecting activity or expression of the upstream enzyme cyclooxygenase-2. In ligature-induced experimental periodontitis, alveolar bone loss, assessed by X-ray imaging, was reduced by 46% by local treatment with TH-848, compared to vehicle, without any systemic effects on PGE2, 6-keto PGF1α, LTB4 or cytokine levels. In summary, these results demonstrate that the aminothiazoles represent novel mPGES-1 inhibitors for inhibition of PGE2 production and reduction of bone resorption in experimental periodontitis, and may be used as potential anti-inflammatory drugs for treatment of chronic inflammatory diseases, including periodontitis.—Kats, A., Båge, T., Georgsson, P., Jönsson, J., Quezada, H. C., Gustafsson, A., Jansson, L., Lindberg, C., Näsström, K., Yucel-Lindberg, T. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo. PMID:23447581

  20. Asymmetry of geomagnetic field horizontal components variation connected to field aligned currents appeared at early recovery phase in region of plasmospheric bulges

    NASA Astrophysics Data System (ADS)

    Barkhatova, Oksana; Barkhatov, Nikolay; Bespalov, Peter

    2010-05-01

    synchronous course of horizontal component at all stations is observed. It can be an evidence of field aligned current existence on boundaries of day time plasmospheric bulge in geomagnetic disturbed period. It can provide flowing of ring current part along field lines and formation of its asymmetry. Registration of disturbances in a range of geomagnetic pulsations Pc-4 in plasmospheric bulge regions can be an additional evidence of longitudinal currents existence. Such pulsations indeed founded out in dynamic spectrums of horizontal components at the stations which are taking place under bulges. We are grateful to Sarah Reay (The British Geological Survey) and Patrik Johansson (Geological Survey of Sweden) for granting of geomagnetic field component records in high resolution. Work is executed at partial support under grants of the RFBR 08-05-12051-OBR and 09-05-00495, and also program Ministry of Education and Science «Development of higher school scientific potential (2009-2010, project N 1623)».

  1. Assessing the snowmelt submodel of TETIS within the DMIP2 project

    NASA Astrophysics Data System (ADS)

    Orozco, Ismael; Francés, Félix

    2010-05-01

    Melt modelling is a crucial element in any attempt to predict runoff from snow-covered or glacierised areas, as well as to assess changes in the cryosphere associated with clime change. In mountainous regions, snow and ice significantly affect catchment hydrology by temporarily storing and releasing water on various time scales (Jansson et al., 2003). Hence, success of runoff modelling in such areas largely depends on accurate quantification of the melt process (Hock, 2003). Snowmelt modelling is complex and dependent on elevation, slope, vegetation type, surface roughness, radiation load, and energy exchange at the snow-air interface (Baron, 1992; Barros and Lettenmaier, 1993; Becker et al., 1994; Cline, 1995; Elder et al., 1991). This paper describes the application of the degree-day method for snowmelt-runoff at hourly time discretization, which is implemented in the distributed and conceptually based hydrological model TETIS, as well as the evaluation of results. In the TETIS model the natural basins are discretizated in grid cells according to drainage network. This conceptualization permits all parameters do not lose its physical meaning (Francés et al., 2007). At each cell the main soil properties need to be estimated previously using topographical, environmental, land use, geological and soil maps. The model has been applied to the Sierra Nevada basins, in USA: the American River (886 km2) and the Carson River (922 km2), as a part of the Distributed Model Intercomparison Project, second phase (DMIP2), of the National Oceanic and Atmospheric Administration's National Weather Service (NOAA/NWS), in which we are participating. These basins are geographically close, but their hidrological regimes are quite different: the Carson River is a high altitude basin with a snow dominated regime; while the American River drains an area that is lower in elevation with precipitation falling as rain and mixed snow and rain (Jeton et al., 1996). Details on the basins

  2. Sensitivity analysis of a soil-vegetation-atmosphere transfer (SVAT) model parameterised for a British floodplain meadow

    NASA Astrophysics Data System (ADS)

    Morris, P. J.; Verhoef, A.; Van der Tol, C.; Macdonald, D.

    2011-12-01

    Rationale: Floodplain meadows are highly species-rich grassland ecosystems, unique in that their vegetation and soil structures have been shaped and maintained by ~1,000 yrs of traditional, low-intensity agricultural management. Widespread development on floodplains over the last two centuries has left few remaining examples of these once commonplace ecosystems and they are afforded high conservation value by British and European agencies. Increased incidences and severity of summer drought and winter flooding in Britain in recent years have placed floodplain plant communities under stress through altered soil moisture regimes. There is a clear need for improved management strategies if the last remaining British floodplain meadows are to be conserved under changing climates. Aim: As part of the Floodplain Underground Sensors Experiment (FUSE, a 3-year project funded by the Natural Environment Research Council) we aim to understand the environmental controls over soil-vegetation-atmosphere transfers (SVAT) of water, CO2 and energy at Yarnton Mead, a floodplain meadow in southern England. An existing model, SCOPE (Soil Canopy Observation, Photochemistry and Energy fluxes; van der Tol et al., 2009), uses remotely-sensed infrared radiance spectra to predict heat and water transfers between a vegetation canopy and the atmosphere. We intend to expand SCOPE by developing a more realistic, physically-based representation of water, gas and energy transfers between soil and vegetation. This improved understanding will eventually take the form of a new submodel within SCOPE, allowing more rigorous estimation of soil-canopy-atmosphere exchanges for the site using predominantly remotely-sensed data. In this context a number of existing SVAT models will be tested and compared to ensure that only reliable and robust underground model components will be coupled to SCOPE. Approach: For this study, we parameterised an existing and widely-used SVAT model (CoupModel; Jansson, 2011

  3. What has happened in about the last 20 years in the Canyoles watershed?

    NASA Astrophysics Data System (ADS)

    Ángel González Peñaloza, Félix; Cerdà, Artemi; Díaz del Olmo, Fernando

    2013-04-01

    Union FP7. ENV.2009 243857. Keywords: GIS, land use, degradation, Cànyoles valley, agricultural practices. References Bodí, M.B., Cerdà, A., Mataix-Solera, J., Doerr, S.H. 2012. Efectos de los incendios forestales en la vegetación y el suelo en la cuenca mediterránea: revisión bibliográfica. Boletín de la Asociación de Geógrafos Españoles 58, 33-35 Cerdà, A, Giménez - Morera, A. Terol, E., Domínguez, A. Jurgensen, M.F., Doerr, S.H. 1999. Cultivos de cítricos y erosión de suelos en el este de la Península Ibérica. En Control de la Degradación de los suelos y cambio global (Eds: Sánchez Díaz, J., Asins Velis, S.). IV Simposio sobre control de la degradación de los suelos y cambio global. Universitat de València. Valencia. 71 - 72. Cerdà, A. 1994. Arroyada superficial en terrazas de cultivo abandonadas. El caso del País Valenciano. Cuadernos de Geografía 56, 135-154 Cerdá, A. 2007. Soil water erosion on road embankments in Eastern Spain. Science of the Total Environments 378, 151-155. González-Peñaloza, F.A., Cerdà, Zavala, L.M., Jordán, A. 2012. Do conservative agriculture practices increase soil water repellency? A case study in citrus-cropped soils. Soil & Tillage Research 124, 233 - 239. Keenleyside, C., Tucker, G.M. 2010. Farmland Abandonment in the EU: An assessment of Trend and Prospects. Report Prepared for WWF. Institute for European Environmental Policy, London. 93 pp. MacDonald, D., Crabtree, J.R., Wiesinger, G., Dax, T., Stamou, N., Fleury, P., Gutiérrez-Lazpita, J., Gibon, A. 2000. Agricultural abandonment in mountain areas of Europe: Environmental consequenses and policy reponse. Journal of Environmental Management 59, 47-69. Piqueras, J. 2012. Geografía del Territorio Valenciano. Departament de Geografia, Universitat de València (Valencia, España). 256 pp. Renwick, A., Jansson, T., Verburg, P.H., Revoredo-Giha, C., Britz, W., Gocht, A., McCracken, D. 2013. Policy reforms and agricultural land abandonment in the EU. Land Use

  4. The enigma of the Australian Alps, young landscapes and missing cryogenic features.

    NASA Astrophysics Data System (ADS)

    Slee, Adrian; Shulmeister, James; Clark, Doug

    2014-05-01

    glaciation. It is also noteworthy that the periglacial features on mainland SE Australia that have absolute ages relate primarily to the last glacial maximum (Barrows et al. 2004). This again contrasts with Tasmania were the periglacial features are both associated with multiple ice ages and are often polygenetic. This presentation reviews geomorphic evidence from two of the highest regions of SE Australia (Bogong High Plains and the Kosciuszko Massif) to determine the extent and nature of cryogenic landscape features in these areas. It will attempt to resolve questions both about the nature of processes operating in these landscapes and add to the debate about the curious paucity of pre-last glacial landscapes at high elevations in SE Australia. References: Barrows, T.T., Stone, J.O., Fifield, L.K. and Cresswell, R.G., 2001. Late Pleistocene glaciation of the Kosciuszko Massif, Snowy Mountains, Australia. Quaternary Research, 55: 179-189 Barrows, T.T., Stone, J. O. and Fifield. L.K, 2004. Exposure ages for Plestocene periglacial deposits in Australia. Quaternary Science Reviews, Vol. 23 (5-6): 697-708 Colhoun, E.A., Kiernan, K., Barrows, T.T. and Geode, A., 2010, Advances in Quaternary studies in Tasmania. Geological Society, London, Special Publications 346:121-139 Glasser, N.F., Jansson, K.N., Harrison, S. and Klenman, J., 2008. The glacial geomorphology and Pleistocene history of South America between 38°S and 56°S. Quaternary Science Reviews 27 (3-4): 365-390 Reeves, J.M., Barrows, T.T., Cohen, T.J., Kiem, A.S., Bostock, H.C., Fitzsimmons, K.E., Jansen, J.D., Kemp, J., Krause, C., Petherick, L. and Phipps, S.J., Climate variability over the last 35,000 years recorded in marine and terrestrial archives in the Australian region: an OZ-INTIMATE compilation. Quaternary Science Reviews 74: 21-34 Shulmeister, J, Thackray, G.D., Rieser, U, Hyatt, O.M, Rother, H., C.C. Smart, and D.J.A. Evans 2010. The stratigraphy, timing and climatic implications of glacilacustrine deposits

  5. EDITORIAL: King of the elements? King of the elements?

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-07-01

    sensitivity can be enhanced by two orders of magnitude when the graphene is doped with an impurity such as boron [11]. Work on graphene has also prompted the possibility of a new field of application in electron-spin-based quantum computing. In this issue, Patrik Recher and Björn Trauzettel in Germany present an overview on the latest research on quantum dots of graphene, graphene nanoribbons and discs in single- and bilayer graphene with a view to their possible application as qubits in computing [12]. Nanodiamonds with nitrogen vacancies have been shown to behave as quantum-dot-like fluorescent nanostructures that are not susceptible to bleaching. Once certain nanotoxicological concerns have been settled, such nanodiamonds may one day be useful for imaging, and means of industrial scale fabrication have already been reported [13]. Other possible medical applications of carbon nanostructures include the use of carbon nanofibres for improved neural and orthopaedic implants [14]. Electronics, sensing, medicine, quantum computing; the utility of carbon in nanotechnology is apparently unlimited. Of course there is as much work in inorganic research advancing as rapidly and in fields just as diverse. Actual commercialisation of devices based on these carbon wonder materials is still pending, but the extraordinary properties of carbon-based materials holds an unavoidable fascination that is likely to endure and inspire further research and discoveries for some time to come. References [1] Kroto H W, Heath J R, O'Brien S C, Curl R F and Smalley R E 1985 Nature 318 162-3 [2] The Nobel Prize in Chemistry 1996 Nobelprize.org http://nobelprize.org/nobel_prizes/chemistry/laureates/1996 [3] Ijima S 1991 Nature 354 56-38 [4] Treacy M M J, Ebbesen T W and Gibson J M 1996 Nature 381 370-80 [5] Cranford S W and Buehler M J 2010 Nanotechnology 21 265706 [6] Wilder J W G, Venema L C, Rinzler A G, Smalley R E and Dekker C 1997 Nature 391 59-62 [7] Che J, Çagin T and Goddard III W A 2000

  6. A genomics investigation of partitioning into and among flavonoid-derived condensed tannins for carbon sequestration in Populus

    SciTech Connect

    Harding, Scott, A; Tsai, Chung-jui; Lindroth, Richard, L

    2013-03-24

    , Canada Work on the design of some of the constructs for the CT transgenics work has been published: Luo K, Harding SA, Tsai C-J (2008) A modified T-vector for simplified assembly of hairpin RNAi constructs. Biotechnology Letters 30: 1271-1274. DOE support from this project was also acknowledged in a book chapter: Douglas CJ, Ehlting J, Harding SA (2009) Phenylpropanoid and Phenolic Metabolism in Populus: Gene Family Structure and Comparative and Functional Genomics In Joshi, C.P., and S.P. DiFazio (eds). Genetics, Genomics and Breeding of Crop Plants: Poplar. Science Publishers, Enfield, New Hampshire. Pp. 304-326 Other work directly related to and supported in part by this project include: Qin H, Feng T, Harding SA, Tsai C-J, Zhang S (2008) An efficient method to identify differentially expressed genes in microarray experiments. Bioinformatics 24: 1583-1589. Tsai C-J, Ranjan P, DiFazio SP, Tuskan GA, Johnson V (2011) Poplar genome microarrays. In: Joshi CP, DiFazio SP and Kole C (eds), Genetics, Genomics and Breeding of Poplars. Science Publishers, Enfield, NH. pp. 112-127. Street N, Tsai C-J (2010) Populus resources and bioinformatics. In: Jansson S, Bhalerao R, and Groover AT (eds), Genetics and Genomics of Populus. Plant Genetics and Genomics: Crops and Models book series. Springer, New York, pp. 135-152.