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Sample records for danielsson patrik jansson

  1. Nine new species of the genus Deinopteroloma Jansson, 1946 (Coleoptera: Staphylinidae: Omaliinae: Anthophagini) from China and Vietnam.

    PubMed

    Shavrin, Alexey V; Smetana, Aleš

    2016-11-22

    Nine new species of the genus Deinopteroloma Jansson, 1946 are described and illustrated: D. bisbisinuatum sp.n. and D. draco sp.n. from China, Sichuan (Gongga Shan), D. emeicola sp.n., D. minor sp.n., D. ruzickai sp.n., D. sextuberculatum sp.n. and D. yinyang sp.n. from China, Sichuan (Emei Shan), D. rougemonti sp.n. from China, Yunnan (Dehong Dai and Jingpo Autonomous Prefecture) and D. vesiculosum sp.n. from North Vietnam. Three species groups within the genus are identified and characterized and closely relationships among them are briefly discussed. A check-list and key to the species of Deinopteroloma are provided. The distribution of all described and recorded species is mapped. Additional records of D. spectabile Smetana, 1996 from Nepal are given.

  2. Patrik and Putrik and Clown Ferdl; Findings and Cognition on the Television Perception of Children and Young People Based on the Prize-Winning Programmes of Prix Jeunesse 1966. Publications of the Internationales Zentralinstitut fur das Jugend- und Bildungsfernsehen, Number 3.

    ERIC Educational Resources Information Center

    Griebel, Francine, Ed.; Burger, Anette, Ed.

    The results of an investigation of the reactions of young children (ranging from four to nine years of age) in France, Germany, England, America, and Czechoslovkia to two Prix Jeunesse winning television films are examined in this document. Summarized reports from each of the participating countries for the film "Patrik and Putrik" and,…

  3. The Historicity of the Physics Class: Enactments, Mimes and Imitation

    ERIC Educational Resources Information Center

    Bergwik, Staffan

    2014-01-01

    This essay discusses Anna Danielsson's article "In the physics class: university physics students' enactments of class and gender in the context of laboratory work". The situated co-construction of knowledge and identity forms the crucial vantage point and I argue that it is a point of intersection between the history of…

  4. Eriosomatine aphids (Hemiptera, Aphididae, Eriosomatinae) associated with moss and roots of conifer and willow in forests of the Pacific Northwest

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Apterous adult morphs of eriosomatine aphids (Hemiptera, Aphididae, Eriosomatinae) associated with moss and/or roots of conifer or willow in forests of the Pacific Northwest including Alaska are described, illustrated, and keyed. In total, seven species (Clydesmithia canadensis Danielsson, Melaphis ...

  5. Neural Networks for Real-Time Sensory Data Processing and Sensorimotor Control

    DTIC Science & Technology

    1991-06-18

    sensory signals at thoracic interneurons of the escape system of the cockroach, Periplaneta americana . Brain Research (in press). In Preparation...Chiel, Roger D. Quinn, Ken Espenschied and Patrik Larsson. "Motion Analysis of Leg Joint Angles during Wind-Evoked Escape Turns of the Cockroach, Periplaneta americana ," by Scott W. Nye and Roy E. Ritzmann.

  6. An Analysis of Network and Sensor Performance Within IEEE 802.X Wireless MESH Networks in the Tactical Network Topology (TNT)

    DTIC Science & Technology

    2005-03-01

    MODEL 1. Determination of the Pareto Optimal Set Multicriteria analysis was founded on the thinking of Vilfredo Pareto (1848-- 1923). He was an...17 Aspers, Patrik, “Crossing the Boundary of Economics and Sociology: The Case of Vilfredo Pareto ,” <http...Sociology: The Case of Vilfredo Pareto ,” <http://www.findarticles.com/p/-articles/mi_m0254/is_2_60/-ai_75451916>, Last accessed 1 March 2005. 25

  7. A First Cut at Doctrine for Automation of Division Command and Control.

    DTIC Science & Technology

    1985-12-02

    Berceau, "ASAS," C2MUG Bulletin (September 1985) op. 1.2. 18. Eric C. Ludvigsen, "Army Weapons," A rmy October 1984), p. 412. 19. Don Schaum et al...October i9o. op. 4(-4;. Riedl. Patri:k H. "Evolutionary Develooment oa C31 Systems.’ S.iqn.a , July 1984. 0o. o’J-b. 44 %***. Schaum . Don. Martin, LTC

  8. JPRS Report, West Europe.

    DTIC Science & Technology

    2007-11-02

    encyclopedia that is impenetrable to outsiders and understandable even to experts only in " lucid moments," in fact needs to be overhauled, in the opinion...formally proposed to the meeting of shareholders that Asea merge with the Swiss dream partner BBC. Only Bengt Goeran Jansson, the representative of the

  9. The Production, Purification and Properties of the Biopolymer Levan Produced by the Bacterium Erwinia Herbicola

    DTIC Science & Technology

    1989-08-01

    with large-scale production in mind. In addition, films formed from the purified polymer were evaluated. Levan is an extracellular B- fructan ...Clarke, M. L., Jansson, P. E. and McNeil, K. E., Fructan from Erwlnla herblcola. J. Bact., 151(3)-.1595-1597 (1982). 23. Han, Y. W., Clarke, M. A

  10. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    NASA Astrophysics Data System (ADS)

    Suominen, Kalle-Antti

    2010-09-01

    information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

  11. Secrets of the Soil (LBNL Science at the Theater)

    SciTech Connect

    Brodie, Eoin; Northen, Trent; Jansson, Janet; Torn, Margaret

    2011-11-07

    Four Berkeley Lab scientists unveil the "Secrets of the Soil"at this Nov. 7, 2011 Science at the Theater event. Eoin Brodie, Janet Jansson, Margaret Torn and Trent Northen talk about their research and how soil could hold the key to our climate and energy future.The discussion was moderated by John Harte, who holds a joint professorship in the Energy and Resources Group and the Ecosystem Sciences Division of UC Berkeley's College of Natural Resources

  12. LIGA-based microsystem manufacturing:the electrochemistry of through-mold depostion and material properties.

    SciTech Connect

    Kelly, James J. (Sandia National Laboratories, Livermore, CA); Goods, Steven Howard (Sandia National Laboratories, Livermore, CA)

    2005-06-01

    The report presented below is to appear in ''Electrochemistry at the Nanoscale'', Patrik Schmuki, Ed. Springer-Verlag, (ca. 2005). The history of the LIGA process, used for fabricating dimensional precise structures for microsystem applications, is briefly reviewed, as are the basic elements of the technology. The principal focus however, is on the unique aspects of the electrochemistry of LIGA through-mask metal deposition and the generation of the fine and uniform microstructures necessary to ensure proper functionality of LIGA components. We draw from both previously published work by external researchers in the field as well as from published and unpublished studies from within Sandia.

  13. World sheet commuting {beta}{gamma} conformal field theory and nonrelativistic string theories

    SciTech Connect

    Kim, Bom Soo

    2007-11-15

    We construct a sigma model in two dimensions with Galilean symmetry in flat target space similar to the sigma model of the critical string theory with Lorentz symmetry in 10 flat spacetime dimensions. This is motivated by the works of Gomis and Ooguri [J. Math. Phys. (N.Y.) 42, 3127 (2001)] and Danielsson et al. [J. High Energy Phys. 10 (2000) 020; J. High Energy Phys. 03 (2001) 041.]. Our theory is much simpler than their theory and does not assume a compact coordinate. This nonrelativistic string theory has a bosonic matter {beta}{gamma} conformal field theory with the conformal weight of {beta} as 1. It is natural to identify time as a linear combination of {gamma} and {gamma} through an explicit realization of the Galilean boost symmetry. The angle between {gamma} and {gamma} parametrizes one parameter family of selection sectors. These selection sectors are responsible for having a nonrelativistic dispersion relation without a nontrivial topology in the nonrelativistic setup, which is one of the major differences from the previous works of Gomis and Ooguri and of Danielsson and co-workers. This simple theory is the nonrelativistic analogue of the critical string theory, and there are many different avenues ahead to be investigated. We mention a possible consistent generalization of this theory with different conformal weights for the {beta}{gamma} conformal field theory. We also mention supersymmetric generalizations of these theories.

  14. Automatic log spectrum restoration of atmospheric seeing

    NASA Astrophysics Data System (ADS)

    Navarro, R.; Gomez, R.; Santamaria, J.

    1987-03-01

    This paper presents an automatic method for (1) digital estimation of the width of the atmospherical seeing in astronomical images of extended objects and (2) image restoration by using the constrained Jansson-Van Cittert deconvolution algorithm. The estimation of the seeing is achieved by computing the radial profile of the averaged log spectrum of the image. The result of this estimation is then applied to compute the Point Spread Function (PSF) used in the deconvolution process. The method is applied to a photographical image of a sunspot. The quality of the restoration assesses the power and usefulness of the method.

  15. Terragenome: International Soil Metagenome Sequencing Consortium (GSC8 Meeting)

    ScienceCinema

    Jansson, Janet [LBNL

    2016-07-12

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Janet Jansson of the Lawrence Berkeley National Laboratory discusses the Terragenome Initiative at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009

  16. Naval Aviation Costs: Targeting Operations and Support

    DTIC Science & Technology

    2013-12-01

    17 Defense AT&L: November–December 2013 Naval Aviation Costs Targeting Operations and Support Capt. Robert Farmer n Capt. Keith Nixon n Capt...ONR Maj. Gen. Murray, TECOM Brig. Gen. Jansson, DLA Aviation SES Gilpin , DASN (Air) SES Stiller, DASN (Ships) SES Zangardi, DASN (C4I) *NAE Air... Robert Brown Training/Training Supt 6.7.6 – Lorie Nace Support Equipment 6.7.7 – Bruce Wilhelm Industrial Business Ops 6.8D – Roy Harris Tech Dir

  17. Handling data redundancy in helical cone beam reconstruction with a cone-angle-based window function and its asymptotic approximation

    SciTech Connect

    Tang Xiangyang; Hsieh Jiang

    2007-06-15

    A cone-angle-based window function is defined in this manuscript for image reconstruction using helical cone beam filtered backprojection (CB-FBP) algorithms. Rather than defining the window boundaries in a two-dimensional detector acquiring projection data for computed tomographic imaging, the cone-angle-based window function deals with data redundancy by selecting rays with the smallest cone angle relative to the reconstruction plane. To be computationally efficient, an asymptotic approximation of the cone-angle-based window function is also given and analyzed in this paper. The benefit of using such an asymptotic approximation also includes the avoidance of functional discontinuities that cause artifacts in reconstructed tomographic images. The cone-angle-based window function and its asymptotic approximation provide a way, equivalent to the Tam-Danielsson-window, for helical CB-FBP reconstruction algorithms to deal with data redundancy, regardless of where the helical pitch is constant or dynamically variable during a scan. By taking the cone-parallel geometry as an example, a computer simulation study is conducted to evaluate the proposed window function and its asymptotic approximation for helical CB-FBP reconstruction algorithm to handle data redundancy. The computer simulated Forbild head and thorax phantoms are utilized in the performance evaluation, showing that the proposed cone-angle-based window function and its asymptotic approximation can deal with data redundancy very well in cone beam image reconstruction from projection data acquired along helical source trajectories. Moreover, a numerical study carried out in this paper reveals that the proposed cone-angle-based window function is actually equivalent to the Tam-Danielsson-window, and rigorous mathematical proofs are being investigated.

  18. Evaluation of Prototype Secondary Hardening Steels for Armor.

    DTIC Science & Technology

    1994-11-01

    Laboratory, ARL- CR -175, August 1994. 3. B. Sundman, B. Jansson, and J.O. Andersson, Calphad , 9, 1985, pp. 153-190. 4. J.H. Graves and J.H. Beatty...this report when it is no longer needed. Do not return it to the originator. Form Approved REPORT DOCUMENTATION PAGE I____ o ._oo_- o ___ Public reporting...actual desired actual desired actual C 0.27 0.21 0.27 0.30 0.27 0.30 Co 12.5 12.46 13.5 13.45 14.5 14.36 Ni 10.0 10.08 10.4 10.59 10.6 10.75 Cr 3.00

  19. The effect of temporal variability of soil moisture on mountain permafrost: a combined model and monitoring approach

    NASA Astrophysics Data System (ADS)

    Pellet, Cécile; Hauck, Christian; Stähli, Manfred

    2016-04-01

    Soil moisture is a key factor controlling the energy and mass exchange processes at the soil-atmosphere interface. In permanently frozen ground it strongly affects the thermal behaviour of the ground by influencing its physical properties such as ice content, thermal conductivity and heat capacity. It also influences other processes like evaporation, infiltration, refreezing rate and runoff and modifies the electrical and electromagnetic properties such as electrical conductivity and permittivity that are used in indirect geophysical and remote sensing methods. In a first attempt to quantify the role of water content, a soil moisture network along an altitudinal gradient in middle and high mountain areas in Switzerland has been initiated, and first results confirm the importance of different water related processes that are dominant at different elevation bands. At very high elevations, in permafrost regions, these processes have not yet been analysed in detail, and current state-of-the-art climate and climate impact simulations are neither calibrated nor validated regarding water content in the subsurface, mostly due to missing data. Using the data from the new soil moisture network in combination with measured in-situ ground temperatures and meteorological parameters (air temperature, global radiation, and wind speed), we calibrated the one dimensional heat and mass transfer model COUP (Jansson, 2012) at all locations. This model was then used to analyse the water balance and more precisely the specific repartition of precipitations into runoff, evaporation and change in moisture content. Finally, we analysed the relations between infiltrating water from the snow cover, phase changes and latent heat release and its influence on subsurface temperature in frozen terrains. REFERENCES Jansson, P.-E. 2012: Coupmodel: Model Use, Calibration and Validation, Transaction of the Asabe, 55(4), 1335-1344.

  20. Full data consistency conditions for cone-beam projections with sources on a plane.

    PubMed

    Clackdoyle, Rolf; Desbat, Laurent

    2013-12-07

    Cone-beam consistency conditions (also known as range conditions) are mathematical relationships between different cone-beam projections, and they therefore describe the redundancy or overlap of information between projections. These redundancies have often been exploited for applications in image reconstruction. In this work we describe new consistency conditions for cone-beam projections whose source positions lie on a plane. A further restriction is that the target object must not intersect this plane. The conditions require that moments of the cone-beam projections be polynomial functions of the source positions, with some additional constraints on the coefficients of the polynomials. A precise description of the consistency conditions is that the four parameters of the cone-beam projections (two for the detector, two for the source position) can be expressed with just three variables, using a certain formulation involving homogeneous polynomials. The main contribution of this work is our demonstration that these conditions are not only necessary, but also sufficient. Thus the consistency conditions completely characterize all redundancies, so no other independent conditions are possible and in this sense the conditions are full. The idea of the proof is to use the known consistency conditions for 3D parallel projections, and to then apply a 1996 theorem of Edholm and Danielsson that links parallel to cone-beam projections. The consistency conditions are illustrated with a simulation example.

  1. World Sheet Commuting beta-gamma CFT and Non-Relativistic StringTheories

    SciTech Connect

    Kim, Bom Soo

    2007-08-30

    We construct a sigma model in two dimensions with Galilean symmetry in flat target space similar to the sigma model of the critical string theory with Lorentz symmetry in 10 flat spacetime dimensions. This is motivated by the works of Gomis and Ooguri[1] and Danielsson et. al.[2, 3]. Our theory is much simpler than their theory and does not assume a compact coordinate. This non-relativistic string theory has a bosonic matter {beta}{gamma} CFT with the conformal weight of {beta} as 1. It is natural to identify time as a linear combination of {gamma} and {bar {gamma}} through an explicit realization of the Galilean boost symmetry. The angle between {gamma} and {bar {gamma}} parametrizes one parameter family of selection sectors. These selection sectors are responsible for having a non-relativistic dispersion relation without a nontrivial topology in the non-relativistic setup, which is one of the major differences from the previous works[1, 2, 3]. This simple theory is the non-relativistic analogue of the critical string theory, and there are many different avenues ahead to be investigated. We mention a possible consistent generalization of this theory with different conformal weights for the {beta}{gamma} CFT. We also mention supersymmetric generalizations of these theories.

  2. Autobiographical memory specificity in patients with tinnitus versus patients with depression and normal controls.

    PubMed

    Andersson, Gerhard; Hesser, Hugo; Cima, Rilana F F; Weise, Cornelia

    2013-01-01

    Several studies show that patients with depression and post-traumatic stress disorder respond with fewer specific autobiographical memories in a cued memory task (i.e. the autobiographical memory test; AMT) compared to healthy controls. One previous study found this phenomenon among tinnitus patients as well (Andersson, Ingerholt, & Jansson, 2003). The aim of this study was to replicate the previous study with an additional control group of depressed patients and memory errors as measured with the AMT as an additional outcome. We included 20 normal hearing tinnitus patients, 20 healthy controls and 20 persons diagnosed with clinical depression. The AMT was administered together with self-report measures of depression, anxiety and tinnitus distress. Both the tinnitus and depression groups differed from the healthy control group in that they reported fewer specific autobiographical memories. There were, however, differences between the tinnitus and depression groups in terms of the errors made on the AMT. The depression group had more overgeneral memories than the normal control group, whereas the tinnitus group did not differ from the control group on this memory error. The tinnitus group had more semantic associations and non-memories than the other two groups, suggesting that executive functioning may play a role for the tinnitus group when completing the AMT. Clinical and theoretical implications of the findings are discussed.

  3. Reproductive rights and health for women.

    PubMed

    Jansson-yanagisawa, Y

    1994-01-01

    Yumiko Jansson-Yanagisawa, a member of Women's Health and Rights, Japan, believes that Japan's Criminal Law, which outlawed abortion 100 years ago, and Eugenic Protection Law (1948), which permits abortion under 5 conditions (the 4th covers the health and economic situation of the mother), should be replaced by a new law that guarantees safe abortion on demand. Her group organizes educational meetings and discussion forums. They have produced a film (a Japanese version of Abortion Stories from North and South, with an accompanying book of responses to the issues raised by the film) and a book (Dangerous Reproductive Revolution) on reproductive technology. In 1990, they unsuccessfully tried to block an attempt to decrease the legal time period for an abortion from 24 weeks to less than 22 weeks. Believing that abortion is a health issue, rather than an ethical one, they would like to see a reference resource of abortion research and statistics for Japan. A larger, national women's organization for reproductive health could conduct research and handle legal issues and paramedical elements of women's health. All aspects of abortion should be illuminated.

  4. Aquatic and semiaquatic Heteroptera (Nepomorpha and Gerromorpha) fauna of Greek holiday islands (Rhodes, Crete and Corfu) with first records of three species from Europe and Greece.

    PubMed

    Csabai, Zoltán; Soós, Nándor; Berchi, Gavril Marius; Cianferoni, Fabio; Boda, Pál; Móra, Arnold

    2017-02-09

    A comprehensive survey on aquatic and semiaquatic bugs (Heteroptera: Nepomorpha and Gerromorpha) of three Greek holiday islands, Rhodes, Crete and Corfu, was conducted from 2007 to 2010 at 237 localities. In this paper, hundreds of detailed records for 30 taxa in nine families are given. The occurrences of Rhagovelia infernalis africana Lundblad, 1936 and Velia mariae Tamanini, 1971 are confirmed and recorded for the first time from Europe sensu stricto. Additionally, some notes on morphology, taxonomy and distribution of the European species of Rhagovelia and Velia are also given, Velia mariae is recorded for the first time not only from several Greek islands, but from continental Greece and Bulgaria as well. Gerris asper (Fieber, 1860), a common European species, was also found for the first time in Greece. Furthermore, new occurrence data are given for endemic taxa; Sigara nigrolineata mendax Heiss & Jansson, 1986 and Velia rhadamantha rhadamantha Hoberlandt, 1941 (whose distribution is restricted to Crete and small adjacent islands) are very common throughout Crete, whereas Ilyocoris cimicoides jonicus (Lindberg, 1922) apparently is rare in Corfu.

  5. PREFACE: Lectures from the European RTN Winter School on Strings, Supergravity and Gauge Fields, Barcelona, 12-16 January 2004

    NASA Astrophysics Data System (ADS)

    Russo, Jorge G.

    2005-04-01

    This issue of Classical and Quantum Gravity contains the proceedings of the RTN European Winter School on Strings, Supergravity and Gauge Fields, which was held at the University of Barcelona, Spain, between 12-16 January 2004. The School was part of the RTN programme The Quantum Structure of Spacetime and the Geometric Nature of Fundamental Interactions of the European Union. It was attended by 181 registered participants. The lectures contain a pedagogical introduction to topics in string theory which are currently under active investigation. They were targeted mainly at students near the end of their PhD, and young postdocs and researchers. The topics were carefully selected to cover phenomenological aspects of string theory, covered by the lectures by A Uranga (Intersecting Brane Worlds) and U Danielsson (String Theory and Cosmology), as well as more fundamental and theoretical issues, covered by N Nekrasov (Non-perturbative Aspects of Supersymmetric Gauge Theories), P Townsend (Branes in Field Theory, not included in these proceedings) and Jaume Gomis (Tachyon Condensation: Towards Time Dependent Backgrounds and Holography). We must thank the lecturers for their admirable exposition of these interesting subjects. We hope that the readers of these proceedings receive these lectures with the same enthusiasm as they were received by all students and physicists that attended the School. Following the tradition of the RTN schools there were, in addition to the lectures, five workgroups on more specialized subjects, which aimed to discuss scientific problems of general interest to our network, facilitate communication between the various groups and, hopefully, help start new collaborations. They were Integrable Structures of the Gauge/String Correspondence led by G Arutyunov and B Stefanski Closed Timelike Curves in Supergravity and String Theory led by N Drukker and L Maoz Black Objects in Higher Dimensional General Relativity and Supergravity led by H Elvang and T

  6. Philosophy and concepts of modern spine surgery.

    PubMed

    José-Antonio, Soriano-Sánchez; Baabor-Aqueveque, Marcos; Silva-Morales, Francisco

    2011-01-01

    The main goal of improving pain and neurological deficit in the practice of spine surgery is changing for a more ambitious goal, namely to improve the overall quality of life and the future of patients through three major actions (1) preserving the vertebral anatomical structures; (2) preserving the paravertebral anatomical structures; and (3) preserving the functionality of the segment. Thus, three new concepts have emerged (a) minimal surgery; (b) minimal access surgery; and (c) motion preservation surgery. These concepts are covered in a new term, minimally invasive spine surgery (MISS) The term "MISS" is not about one or several particular surgical techniques, but a new way of thinking, a new philosophy. Although the development of minimally invasive spine surgery is recent, its application includes all spine segments and almost all the existing conditions, including deformities.Evidence-based medicine (EBM), a term coined by Alvan Feinstein in the 1960s (Feinstein A (1964) Annals of Internal Medicine 61: 564-579; Feinstein A (1964) Annals of Internal Medicine 61: 757-781; Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), emphasizes the possibility of combining art and science following the strict application of scientific methods in the treatment of patients (Feinstein A (1964) Annals of Internal Medicine 61: 944-965; Feinstein A (1964) Annals of Internal Medicine 61: 1162-1193.), which may represent the advantages of objectivity and rationality in the use of different treatments (Fig. 11). However, EBM has many obvious defects, especially in spine surgery it is almost impossible to develop double-blind protocols (Andersson G, Bridwell K, Danielsson A, et al (2007) Spine 32: S64-S65.). In most cases, the only evidence one can find in the literature is the lack of evidence (Resnick D (2007) Spine 32:S15-S19.), however, the lack of evidence does not mean its absence. Only then, with a

  7. Estimation of extreme precipitation; Return period values and PMP for Norway

    NASA Astrophysics Data System (ADS)

    Engen-Skaugen, Torill; Alfnes, Eli; Førland, Eirik J.

    2010-05-01

    Estimates of extreme values of precipitation represented as return period values and Probable Maximum Precipitation (PMP) are frequently used in flood evaluation as well as dimensioning of hydro power dams. The estimates are also of interest for infrastructure constructions (e.g. urban runoff). The estimates establish a reference to how rare a heavy rainfall event at a location is. This study presents present-day and future return period values and PMP estimates for several catchments in Norway. Daily precipitation values are extracted from grids covering the Norwegian mainland, spatial resolution 1 x 1 km2, for the time period 1957 - 2009. The grids are interpolated from observations at all available rain gage stations operated by the Norwegian Meteorolgoical Institute in Norway. The maps can be seen at http://senorge.no (Mohr, 2009; Jansson et al., 2007). The rain gauge network in the high mountain region is sparse, leading to reduced quality in these regions. A rough correction of daily gauge precipitation for undercatch because of wind exposure is performed before interpolation. Six climate projections downscaled with different Regional Climate Models (RCMs) are adjusted to be representative locally for the Norwegian mainland (Engen-Skaugen, 2007). Daily precipitation projections are established for the same grid extent as for observations. Time series of daily precipitation are then extracted from these grids representing the same catchments as the historic data. The estimates of extreme precipitation are based on daily precipitation values (Førland, 1992; Alfnes, 2007). Instead of producing area estimates based on site values adjusted by an Area Reduction Factor (ARF), area estimates in the present study is based on time series of daily precipitation representing the actual catchments extracted from the high resolution grids. Alfnes (2007) found that the five-year return value estimates (M5) for these two methods were similar, with exceptions for catchments

  8. Changes in thyroid parameters of hatchling American kestrels (Falco sparverius) following embryonic exposure to technical short chain chlorinated paraffins (SCCPs; C10-13, 55.5% CL)

    USGS Publications Warehouse

    Fernie, Kimberly J; Henry, Paula F.; Letcher, Robert J; Palace, Vince; Peters, Lisa; Rattner, Barnett A.; Sverko, Edward; Karouna, Natalie

    2015-01-01

    Chlorinated paraffins (CPs) are complex mixtures of polychlorinated n-alkanes categorized according to their carbon chain length: short chain (SCCPs, C10 – C13), medium (C14 - C17), and long chain (C>17), chlorinated paraffins. SCCPs are primarily used in metalworking applications, as flame retardants, and in paints, adhesives, sealants, textiles, plastics and rubber (UNEP 2012). In 2012, the United Nations Environment Program (UNEP 2012) reported in the Revised Draft Risk Profile for SCCPs, that CPs were produced in the United States, the European Union (EU), Slovakia, Brazil, India, Japan and China. While annual global consumption of SCCPs is large (>25 tonnes/year), it has sharply declined over the past 20 years. SCCPs are released through wastewater, landfills, and air emissions (UNEP 2012). Concentrations of SCCPs have been reported in fish and marine mammals in North and South America, Europe, Japan, Greenland and the Arctic (UNEP 2012 and references therein). Characterization of SCCP concentrations and exposure in terrestrial wildlife is limited. In 2010, SCCP concentrations were reported in the eggs of yellow-legged gulls (Larus michahellis) (4536 ± 40 pg/g wet weight (ww)) and Audouin’s gulls (Larus audouinii) (6364 ± 20 pg/g ww) in Spain (Morales et al. 2012), and little auks (Alle alle) (5 - 88 ng/g ww) and kittiwakes (Rissa tridactyla) (5 - 44 ng/g ww) in the European Arctic (Reth et al. 2006). In Sweden, muscle of ospreys contained CPs of unspecified chain length (Jansson et al. 1993). Although the toxicity of SCCPs has been demonstrated in aquatic invertebrates, fish, frogs, and laboratory rats, there are limited avian studies and these reported no effects of SCCPs on egg parameters of domestic hens (Gallus gallus domesticus) and ducks (Anas platyrhynchos) (UNEP 2012). Despite reported accumulation of SCCPs in wild birds, to our knowledge, exposure-related toxicities and effects with respect to avian wildlife remain unknown.

  9. Open-Source Sequence Clustering Methods Improve the State Of the Art.

    PubMed

    Kopylova, Evguenia; Navas-Molina, Jose A; Mercier, Céline; Xu, Zhenjiang Zech; Mahé, Frédéric; He, Yan; Zhou, Hong-Wei; Rognes, Torbjørn; Caporaso, J Gregory; Knight, Rob

    2016-01-01

    Sequence clustering is a common early step in amplicon-based microbial community analysis, when raw sequencing reads are clustered into operational taxonomic units (OTUs) to reduce the run time of subsequent analysis steps. Here, we evaluated the performance of recently released state-of-the-art open-source clustering software products, namely, OTUCLUST, Swarm, SUMACLUST, and SortMeRNA, against current principal options (UCLUST and USEARCH) in QIIME, hierarchical clustering methods in mothur, and USEARCH's most recent clustering algorithm, UPARSE. All the latest open-source tools showed promising results, reporting up to 60% fewer spurious OTUs than UCLUST, indicating that the underlying clustering algorithm can vastly reduce the number of these derived OTUs. Furthermore, we observed that stringent quality filtering, such as is done in UPARSE, can cause a significant underestimation of species abundance and diversity, leading to incorrect biological results. Swarm, SUMACLUST, and SortMeRNA have been included in the QIIME 1.9.0 release. IMPORTANCE Massive collections of next-generation sequencing data call for fast, accurate, and easily accessible bioinformatics algorithms to perform sequence clustering. A comprehensive benchmark is presented, including open-source tools and the popular USEARCH suite. Simulated, mock, and environmental communities were used to analyze sensitivity, selectivity, species diversity (alpha and beta), and taxonomic composition. The results demonstrate that recent clustering algorithms can significantly improve accuracy and preserve estimated diversity without the application of aggressive filtering. Moreover, these tools are all open source, apply multiple levels of multithreading, and scale to the demands of modern next-generation sequencing data, which is essential for the analysis of massive multidisciplinary studies such as the Earth Microbiome Project (EMP) (J. A. Gilbert, J. K. Jansson, and R. Knight, BMC Biol 12:69, 2014, http

  10. Interspecific variation in resistance of Asian, European, and North American birches (Betula spp.) to bronze birch borer (Coleoptera: Buprestidae).

    PubMed

    Nielsen, David G; Muilenburg, Vanessa L; Herms, Daniel A

    2011-06-01

    Bronze birch borer (Agrilus anxius Gory) is the key pest of birches (Betula spp.) in North America, several of which have been recommended for ornamental landscapes based on anecdotal reports of borer resistance that had not been confirmed experimentally. In a 20-yr common garden experiment initiated in 1979 in Ohio, North American birch species, including paper birch (Betula papyrifera Marshall), 'Whitespire' gray birch (Betula populifolia Marshall), and river birch (Betula nigra L.), were much more resistant to bronze birch borer than species indigenous to Europe and Asia, including European white birch (Betula pendula Roth), downy birch (Betula pubescens Ehrh.), monarch birch (Betula maximowicziana Regel), and Szechuan white birch (Betula szechuanica Jansson). Within 8 yr of planting, every European white, downy, and Szechuan birch had been colonized and killed, although 100% of monarch birch had been colonized and 88% of these plants were killed after nine years. Conversely, 97% of river birch, 76% of paper birch, and 73% Whitespire gray birch were alive 20 yr after planting, and river birch showed no evidence of colonization. This pattern is consistent with biogeographic theory of plant defense: North American birch species that share a coevolutionary history with bronze birch borer were much more resistant than naïve hosts endemic to Europe and Asia, possibly by virtue of evolution of targeted defenses. This information suggests that if bronze birch borer were introduced to Europe or Asia, it could threaten its hosts there on a continental scale. This study also exposed limitations of anecdotal observation as evidence of host plant resistance.

  11. Model-free deconvolution of femtosecond kinetic data.

    PubMed

    Bányász, Akos; Keszei, Erno

    2006-05-18

    Though shorter laser pulses can also be produced, pulses of the 100 fs range are typically used in femtosecond kinetic measurements, which are comparable to characteristic times of the studied processes, making detection of the kinetic response functions inevitably distorted by convolution with the pulses applied. A description of this convolution in terms of experiments and measurable signals is given, followed by a detailed discussion of a large number of available methods to solve the convolution equation to get the undistorted kinetic signal, without any presupposed kinetic or photophysical model of the underlying processes. A thorough numerical test of several deconvolution methods is described, and two iterative time-domain methods (Bayesian and Jansson deconvolution) along with two inverse filtering frequency-domain methods (adaptive Wiener filtering and regularization) are suggested to use for the deconvolution of experimental femtosecond kinetic data sets. Adaptation of these methods to typical kinetic curve shapes is described in detail. We find that the model-free deconvolution gives satisfactory results compared to the classical "reconvolution" method where the knowledge of the kinetic and photophysical mechanism is necessary to perform the deconvolution. In addition, a model-free deconvolution followed by a statistical inference of the parameters of a model function gives less biased results for the relevant parameters of the model than simple reconvolution. We have also analyzed real-life experimental data and found that the model-free deconvolution methods can be successfully used to get undistorted kinetic curves in that case as well. A graphical computer program to perform deconvolution via inverse filtering and additional noise filters is also provided as Supporting Information. Though deconvolution methods described here were optimized for femtosecond kinetic measurements, they can be used for any kind of convolved data where measured

  12. The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice

    PubMed Central

    Fagman, Johan B.; Wilhelmson, Anna S.; Motta, Benedetta M.; Pirazzi, Carlo; Alexanderson, Camilla; De Gendt, Karel; Verhoeven, Guido; Holmäng, Agneta; Anesten, Fredrik; Jansson, John-Olov; Levin, Malin; Borén, Jan; Ohlsson, Claes; Krettek, Alexandra; Romeo, Stefano; Tivesten, Åsa

    2015-01-01

    Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)–dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein E (apoE)–deficient background. After 8 weeks on a high-fat diet, but not on a normal chow diet, atherosclerosis in aorta was increased in ARKO females (+59% vs. control apoE-deficient mice with intact AR gene). They also displayed increased body weight (+18%), body fat percentage (+62%), and hepatic triglyceride levels, reduced insulin sensitivity, and a marked atherogenic dyslipidemia (serum cholesterol, +52%). Differences in atherosclerosis, body weight, and lipid levels between ARKO and control mice were abolished in mice that were ovariectomized before puberty, consistent with a protective action of ovarian androgens mediated via the AR. Furthermore, the AR agonist dihydrotestosterone reduced atherosclerosis (−41%; thoracic aorta), subcutaneous fat mass (−44%), and cholesterol levels (−35%) in ovariectomized mice, reduced hepatocyte lipid accumulation in hepatoma cells in vitro, and regulated mRNA expression of hepatic genes pivotal for lipid homeostasis. In conclusion, we demonstrate that the AR protects against diet-induced atherosclerosis in female mice and propose that this is mediated by modulation of body composition and lipid metabolism.—Fagman, J. B., Wilhelmson, A. S., Motta, B. M., Pirazzi, C., Alexanderson, C., De Gendt, K., Verhoeven, G., Holmäng, A., Anesten, F., Jansson, J.-O., Levin, M., Borén, J., Ohlsson, C., Krettek, A., Romeo, S., Tivesten, A. The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice. PMID:25550469

  13. Hydrological functioning of gullies and inter-rill areas during the initial stage of a developing ecosystem

    NASA Astrophysics Data System (ADS)

    Stähli, Manfred; Hofer, Markus; Völksch, Ingo; Biemelt, Detlef; Gustafsson, David

    2010-05-01

    Gullies up to a few meters wide and up to one meter deep, as well as intermediate rather flat areas (so called inter-rill areas) are the two opposing characteristic surface features of the artificial research catchment 'Chicken Creek' in the vicinity of Cottbus (eastern Germany). They have emerged and intensified during the first five years of the ecosystem development. The present study aims at highlighting their hydrological functioning through a combination of in-situ and remote sensing of near-surface water content with numerical soil hydraulic modelling. A time series of more than one year of near-surface soil water contents was obtained from approximately thirty spatially distributed Decagon sensors at a depth of 10 to 15 cm, as well as from an L-band radiometer positioned on a 10-m high tower facing a footprint area in the research catchment of approximately 100 m2. They were used to verify a one-dimensional soil water and heat transfer model (COUP, Jansson and Karlberg, 2002) simulating surface runoff, infiltration and groundwater recharge for typical gully and inter-rill areas. The model was fed with detailed information about soil hydraulic properties and driven with hourly meteorological data. After calibration the numerical model correlated very well with the soil moisture measurements of the inter-rill areas (R2 = 0.68; root mean square error = 0.028 m3 m-3). This good agreement suggests that the chosen hydraulic properties of the uppermost soil layers are appropriate and that the simulated soil evaporation and snow dynamics are plausible. Also the much less dynamic soil water content in the gullies was reproduced well by the model. The seemingly appropriate simulation of the near-surface water dynamics, suggesting most of the precipitation to infiltrate and percolate to the groundwater, contradicts visual observations that surface runoff is the dominant runoff mechanism during rain storms. This unsolved discrepancy shall be further investigated in the

  14. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo

    PubMed Central

    Kats, Anna; Båge, Tove; Georgsson, Pierre; Jönsson, Jörgen; Quezada, Hernán Concha; Gustafsson, Anders; Jansson, Leif; Lindberg, Claes; Näsström, Karin; Yucel-Lindberg, Tülay

    2013-01-01

    The potent inflammatory mediator prostaglandin E2 (PGE2) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE2 biosynthesis, is an attractive target for selective PGE2 inhibition. To identify mPGES-1 inhibitors, we investigated the effect of aminothiazoles on inflammation-induced PGE2 synthesis in vitro, using human gingival fibroblasts stimulated with the cytokine IL-1β and a cell-free mPGES-1 activity assay, as well as on inflammation-induced bone resorption in vivo, using ligature-induced experimental periodontitis in Sprague-Dawley rats. Aminothiazoles 4-([4-(2-naphthyl)-1,3-thiazol-2-yl]amino)phenol (TH-848) and 4-(3-fluoro-4-methoxyphenyl)-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine (TH-644) reduced IL-1β-induced PGE2 production in fibroblasts (IC50 1.1 and 1.5 μM, respectively) as well as recombinant mPGES-1 activity, without affecting activity or expression of the upstream enzyme cyclooxygenase-2. In ligature-induced experimental periodontitis, alveolar bone loss, assessed by X-ray imaging, was reduced by 46% by local treatment with TH-848, compared to vehicle, without any systemic effects on PGE2, 6-keto PGF1α, LTB4 or cytokine levels. In summary, these results demonstrate that the aminothiazoles represent novel mPGES-1 inhibitors for inhibition of PGE2 production and reduction of bone resorption in experimental periodontitis, and may be used as potential anti-inflammatory drugs for treatment of chronic inflammatory diseases, including periodontitis.—Kats, A., Båge, T., Georgsson, P., Jönsson, J., Quezada, H. C., Gustafsson, A., Jansson, L., Lindberg, C., Näsström, K., Yucel-Lindberg, T. Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo. PMID:23447581

  15. Lipids and Molecular Tools as Biomarkers in Monitoring Air Sparging Bioremediation Processes

    NASA Astrophysics Data System (ADS)

    Heipieper, Hermann J.; Fischer, Janett

    2010-05-01

    .J., Junca H. (2009) Enhancement of the microbial community biomass and diversity during air sparging bioremediation of a Northern Bohemia soil highly contaminated with kerosene and BTEX. Appl. Microbiol. Biotechnol. 82:565-577. Heipieper H.J. (2009) Isolation and analysis of lipids, biomarkers. In: Timmis K.N. (Ed.) Handbook of Hydrocarbon and Lipid Microbiology. Springer, Berlin. Vol. 5, Part 2, pp. 3743-3750. Unell M., Kabelitz N., Jansson J.K., Heipieper H.J. (2007) Adaptation of the psychrotroph Arthrobacter chlorophenolicus A6 to growth temperature and the presence of phenols by changes in the anteiso/iso ratio of branched fatty acids. FEMS Microbiol. Lett. 266 : 138-143.

  16. Thermal Regime Change of a Retreating Polythermal Glacier from Repeat Ground Penetrating Radar

    NASA Astrophysics Data System (ADS)

    Rippin, D. M.; Willis, I. C.; Sevestre, H.

    2014-12-01

    Polythermal glaciers (i.e. glaciers that consist of some combination of both warm and cold ice) are common in the Arctic (e.g. Aschwanden and Blatter, 2005). Recent work (e.g. Rippin et al. 2011; Gusmeroli et al., 2012; Wilson and Flowers, 2013; Wilson et al., 2013) has focussed on how their polythermal structure might change in response to a warming climate. These studies suggest that the nature of future thermal regime change is complex, such that the relative volume of temperate ice in a shrinking glacier may increase or decrease, depending on local geographical, meteorological and hydrological parameters. Here, we present a unique data-set from the well-studied glacier Midtre Lovénbreen in Svalbard, which has shown continued and sustained retreat in recent years. We have a network of ground penetrating radar (GPR) lines from this glacier, first surveyed in 2006 and then repeat-surveyed along exactly the same lines in 2012. Despite significant retreat and thinning, our data suggests that minimal changes in thermal regime have taken place over this period, reinforcing previous observations of a significant lag in the rate at which the thermal regime responds to mass balance changes (cf. Rippin et al., 2011). Such a 'thermal lag' has implications for evolving hydrological and dynamical behaviour of these glaciers, and also for the future mass balance response. In this paper, we comment on the observed changes and consider the implications for our understanding of future thermal regime evolution. ReferencesAschwanden, A., and H. Blatter. 2005. Meltwater production due to strain heating in Storglaciären, Sweden. JGR, 110, doi:10.1029/2005JF000,328. Rippin, D.M., J.L. Carrivick and C. Williams. 2011. Evidence towards a thermal lag in the response of Kårsaglaciären, northern Sweden, to climate change. J. Glac., 57(205), 895-903. Gusmeroli, A., P. Jansson, R. Pettersson and T. Murray. 2012. Twenty years of cold surface layer thinning at Storglaciaren, sub

  17. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients

    PubMed Central

    Friberg, Lena E.; Pontikis, Konstantinos; Ioannidis, Konstantinos; Tsagkari, Vasiliki; Galani, Lamprini; Kostakou, Eirini; Baziaka, Fotini; Paskalis, Charalambos; Koutsoukou, Antonia; Giamarellou, Helen

    2015-01-01

    Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430–3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241– 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284–3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups

  18. Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients.

    PubMed

    Karaiskos, Ilias; Friberg, Lena E; Pontikis, Konstantinos; Ioannidis, Konstantinos; Tsagkari, Vasiliki; Galani, Lamprini; Kostakou, Eirini; Baziaka, Fotini; Paskalis, Charalambos; Koutsoukou, Antonia; Giamarellou, Helen

    2015-12-01

    Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as the last-resort treatment in critically ill patients. Recent studies focusing on the optimal dosing strategy of colistin have demonstrated the necessity of a loading dose at treatment initiation (D. Plachouras, M. Karvanen, L. E. Friberg, E. Papadomichelakis, A. Antoniadou, I. Tsangaris, I. Karaiskos, G. Poulakou, F. Kontopidou, A. Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430-3436, 2009, http://dx.doi.org/10.1128/AAC.01361-08; A. F. Mohamed, I. Karaiskos, D. Plachouras, M. Karvanen, K. Pontikis, B. Jansson, E. Papadomichelakis, A. Antoniadou, H. Giamarellou, A. Armaganidis, O. Cars, and L. E. Friberg, Antimicrob Agents Chemother 56:4241- 4249, 2012, http://dx.doi.org/10.1128/AAC.06426-11; S. M. Garonzik, J. Li, V. Thamlikitkul, D. L. Paterson, S. Shoham, J. Jacob, F. P. Silveira, A. Forrest, and R. L. Nation, Antimicrob Agents Chemother 55:3284-3294, 2011, http://dx.doi.org/10.1128/AAC.01733-10). In 19 critically ill patients with suspected or microbiologically documented infections caused by XDR Gram-negative strains, a loading dose of 9 MU colistin methanesulfonate (CMS) (∼ 270 mg colistin base activity) was administered with a maintenance dose of 4.5 MU every 12 h, commenced after 24 h. Patients on renal replacement were excluded. CMS infusion was given over 30 min or 1 h. Repeated blood sampling was performed after the loading dose and after the 5th or 6th dose. Colistin concentrations and measured CMS, determined after hydrolization to colistin and including the partially sulfomethylated derivatives, were determined with a liquid chromatography-tandem mass spectrometry assay. Population pharmacokinetic analysis was conducted in NONMEM with the new data combined with data from previous studies. Measured colistimethate concentrations were described by 4 compartments for distribution and removal of sulfomethyl groups, while

  19. The Galactic Magnetic Field and its lensing of Ultrahigh Energy and Galactic Cosmic Rays

    NASA Astrophysics Data System (ADS)

    Farrar, Glennys

    2015-08-01

    It has long been recognized that magnetic fields play an important role in many astrophysical environments, but the magnetic field strength and structure has only been quantitatively determined for relatively few systems beyond our solar system.Our understanding of the Galactic magnetic field (GMF) has improved tremendously in recent years. The Jansson-Farrar (2012) (JF12) GMF model is the most realistic and comprehensive model available. It was constrained by fitting all-sky Faraday Rotation Measures of ~40k extragalactic sources, simultaneously with WMAP polarized (Q,U) and total synchrotron emission maps - together providing a total of more than 10,000 independent datapoints, each with measured astrophysical variance. In addition to disk and toroidal halo components, a previously overlooked coherent poloidal halo field proves to be necessary to account for the RM, Q and U data. Moreover a “striated” random component is needed in addition to a fully random component, in both disk and halo.The talk will give a concise review of the JF12 model and its derivation, with emphasis on which features of the GMF are well or poorly established. I will show that the data unambiguously demand a large scale coherent component to the halo field which is a diverging-spiral centered on the Galactic center, with field lines running from Southern to Northern hemispheres. The puzzles posed by the large scale coherent halo and disk magnetic fields, and their possible origins, will be discussed.Having a good model of the Galactic magnetic field is crucial for determining the sources of UHECRs, for modeling the transport of Galactic CRs (the halo field provides a heretofore-overlooked escape route for by diffusion along its field lines), and for calculating the background to dark matter and CMB-cosmology studies. I will present new results on the lensing effect of the GMF on UHECRs, which produces multiple images and dramatic magnification and demagnification that varies with

  20. Bioreactors for Tissue Engineering of Cartilage

    NASA Astrophysics Data System (ADS)

    Concaro, S.; Gustavson, F.; Gatenholm, P.

    The cartilage regenerative medicine field has evolved during the last decades. The first-generation technology, autologous chondrocyte transplantation (ACT) involved the transplantation of in vitro expanded chondrocytes to cartilage defects. The second generation involves the seeding of chondrocytes in a three-dimensional scaffold. The technique has several potential advantages such as the ability of arthroscopic implantation, in vitro pre-differentiation of cells and implant stability among others (Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L, N Engl J Med 331(14):889-895, 1994; Henderson I, Francisco R, Oakes B, Cameron J, Knee 12(3):209-216, 2005; Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A, Clin Orthop (374):212-234, 2000; Nagel-Heyer S, Goepfert C, Feyerabend F, Petersen JP, Adamietz P, Meenen NM, et al. Bioprocess Biosyst Eng 27(4):273-280, 2005; Portner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, J Biosci Bioeng 100(3):235-245, 2005; Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, Portner R, J Biotechnol 121(4):486-497, 2006; Heyland J, Wiegandt K, Goepfert C, Nagel-Heyer S, Ilinich E, Schumacher U, et al. Biotechnol Lett 28(20):1641-1648, 2006). The nutritional requirements of cells that are synthesizing extra-cellular matrix increase along the differentiation process. The mass transfer must be increased according to the tissue properties. Bioreactors represent an attractive tool to accelerate the biochemical and mechanical properties of the engineered tissues providing adequate mass transfer and physical stimuli. Different reactor systems have been [5] developed during the last decades based on different physical stimulation concepts. Static and dynamic compression, confined and nonconfined compression-based reactors have been described in this review. Perfusion systems represent an attractive way of culturing constructs under dynamic conditions. Several groups showed increased matrix

  1. Sensitivity analysis of a soil-vegetation-atmosphere transfer (SVAT) model parameterised for a British floodplain meadow

    NASA Astrophysics Data System (ADS)

    Morris, P. J.; Verhoef, A.; Van der Tol, C.; Macdonald, D.

    2011-12-01

    Rationale: Floodplain meadows are highly species-rich grassland ecosystems, unique in that their vegetation and soil structures have been shaped and maintained by ~1,000 yrs of traditional, low-intensity agricultural management. Widespread development on floodplains over the last two centuries has left few remaining examples of these once commonplace ecosystems and they are afforded high conservation value by British and European agencies. Increased incidences and severity of summer drought and winter flooding in Britain in recent years have placed floodplain plant communities under stress through altered soil moisture regimes. There is a clear need for improved management strategies if the last remaining British floodplain meadows are to be conserved under changing climates. Aim: As part of the Floodplain Underground Sensors Experiment (FUSE, a 3-year project funded by the Natural Environment Research Council) we aim to understand the environmental controls over soil-vegetation-atmosphere transfers (SVAT) of water, CO2 and energy at Yarnton Mead, a floodplain meadow in southern England. An existing model, SCOPE (Soil Canopy Observation, Photochemistry and Energy fluxes; van der Tol et al., 2009), uses remotely-sensed infrared radiance spectra to predict heat and water transfers between a vegetation canopy and the atmosphere. We intend to expand SCOPE by developing a more realistic, physically-based representation of water, gas and energy transfers between soil and vegetation. This improved understanding will eventually take the form of a new submodel within SCOPE, allowing more rigorous estimation of soil-canopy-atmosphere exchanges for the site using predominantly remotely-sensed data. In this context a number of existing SVAT models will be tested and compared to ensure that only reliable and robust underground model components will be coupled to SCOPE. Approach: For this study, we parameterised an existing and widely-used SVAT model (CoupModel; Jansson, 2011

  2. Assessing the snowmelt submodel of TETIS within the DMIP2 project

    NASA Astrophysics Data System (ADS)

    Orozco, Ismael; Francés, Félix

    2010-05-01

    Melt modelling is a crucial element in any attempt to predict runoff from snow-covered or glacierised areas, as well as to assess changes in the cryosphere associated with clime change. In mountainous regions, snow and ice significantly affect catchment hydrology by temporarily storing and releasing water on various time scales (Jansson et al., 2003). Hence, success of runoff modelling in such areas largely depends on accurate quantification of the melt process (Hock, 2003). Snowmelt modelling is complex and dependent on elevation, slope, vegetation type, surface roughness, radiation load, and energy exchange at the snow-air interface (Baron, 1992; Barros and Lettenmaier, 1993; Becker et al., 1994; Cline, 1995; Elder et al., 1991). This paper describes the application of the degree-day method for snowmelt-runoff at hourly time discretization, which is implemented in the distributed and conceptually based hydrological model TETIS, as well as the evaluation of results. In the TETIS model the natural basins are discretizated in grid cells according to drainage network. This conceptualization permits all parameters do not lose its physical meaning (Francés et al., 2007). At each cell the main soil properties need to be estimated previously using topographical, environmental, land use, geological and soil maps. The model has been applied to the Sierra Nevada basins, in USA: the American River (886 km2) and the Carson River (922 km2), as a part of the Distributed Model Intercomparison Project, second phase (DMIP2), of the National Oceanic and Atmospheric Administration's National Weather Service (NOAA/NWS), in which we are participating. These basins are geographically close, but their hidrological regimes are quite different: the Carson River is a high altitude basin with a snow dominated regime; while the American River drains an area that is lower in elevation with precipitation falling as rain and mixed snow and rain (Jeton et al., 1996). Details on the basins

  3. EDITORIAL: King of the elements? King of the elements?

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-07-01

    sensitivity can be enhanced by two orders of magnitude when the graphene is doped with an impurity such as boron [11]. Work on graphene has also prompted the possibility of a new field of application in electron-spin-based quantum computing. In this issue, Patrik Recher and Björn Trauzettel in Germany present an overview on the latest research on quantum dots of graphene, graphene nanoribbons and discs in single- and bilayer graphene with a view to their possible application as qubits in computing [12]. Nanodiamonds with nitrogen vacancies have been shown to behave as quantum-dot-like fluorescent nanostructures that are not susceptible to bleaching. Once certain nanotoxicological concerns have been settled, such nanodiamonds may one day be useful for imaging, and means of industrial scale fabrication have already been reported [13]. Other possible medical applications of carbon nanostructures include the use of carbon nanofibres for improved neural and orthopaedic implants [14]. Electronics, sensing, medicine, quantum computing; the utility of carbon in nanotechnology is apparently unlimited. Of course there is as much work in inorganic research advancing as rapidly and in fields just as diverse. Actual commercialisation of devices based on these carbon wonder materials is still pending, but the extraordinary properties of carbon-based materials holds an unavoidable fascination that is likely to endure and inspire further research and discoveries for some time to come. References [1] Kroto H W, Heath J R, O'Brien S C, Curl R F and Smalley R E 1985 Nature 318 162-3 [2] The Nobel Prize in Chemistry 1996 Nobelprize.org http://nobelprize.org/nobel_prizes/chemistry/laureates/1996 [3] Ijima S 1991 Nature 354 56-38 [4] Treacy M M J, Ebbesen T W and Gibson J M 1996 Nature 381 370-80 [5] Cranford S W and Buehler M J 2010 Nanotechnology 21 265706 [6] Wilder J W G, Venema L C, Rinzler A G, Smalley R E and Dekker C 1997 Nature 391 59-62 [7] Che J, Çagin T and Goddard III W A 2000

  4. The enigma of the Australian Alps, young landscapes and missing cryogenic features.

    NASA Astrophysics Data System (ADS)

    Slee, Adrian; Shulmeister, James; Clark, Doug

    2014-05-01

    glaciation. It is also noteworthy that the periglacial features on mainland SE Australia that have absolute ages relate primarily to the last glacial maximum (Barrows et al. 2004). This again contrasts with Tasmania were the periglacial features are both associated with multiple ice ages and are often polygenetic. This presentation reviews geomorphic evidence from two of the highest regions of SE Australia (Bogong High Plains and the Kosciuszko Massif) to determine the extent and nature of cryogenic landscape features in these areas. It will attempt to resolve questions both about the nature of processes operating in these landscapes and add to the debate about the curious paucity of pre-last glacial landscapes at high elevations in SE Australia. References: Barrows, T.T., Stone, J.O., Fifield, L.K. and Cresswell, R.G., 2001. Late Pleistocene glaciation of the Kosciuszko Massif, Snowy Mountains, Australia. Quaternary Research, 55: 179-189 Barrows, T.T., Stone, J. O. and Fifield. L.K, 2004. Exposure ages for Plestocene periglacial deposits in Australia. Quaternary Science Reviews, Vol. 23 (5-6): 697-708 Colhoun, E.A., Kiernan, K., Barrows, T.T. and Geode, A., 2010, Advances in Quaternary studies in Tasmania. Geological Society, London, Special Publications 346:121-139 Glasser, N.F., Jansson, K.N., Harrison, S. and Klenman, J., 2008. The glacial geomorphology and Pleistocene history of South America between 38°S and 56°S. Quaternary Science Reviews 27 (3-4): 365-390 Reeves, J.M., Barrows, T.T., Cohen, T.J., Kiem, A.S., Bostock, H.C., Fitzsimmons, K.E., Jansen, J.D., Kemp, J., Krause, C., Petherick, L. and Phipps, S.J., Climate variability over the last 35,000 years recorded in marine and terrestrial archives in the Australian region: an OZ-INTIMATE compilation. Quaternary Science Reviews 74: 21-34 Shulmeister, J, Thackray, G.D., Rieser, U, Hyatt, O.M, Rother, H., C.C. Smart, and D.J.A. Evans 2010. The stratigraphy, timing and climatic implications of glacilacustrine deposits

  5. What has happened in about the last 20 years in the Canyoles watershed?

    NASA Astrophysics Data System (ADS)

    Ángel González Peñaloza, Félix; Cerdà, Artemi; Díaz del Olmo, Fernando

    2013-04-01

    Union FP7. ENV.2009 243857. Keywords: GIS, land use, degradation, Cànyoles valley, agricultural practices. References Bodí, M.B., Cerdà, A., Mataix-Solera, J., Doerr, S.H. 2012. Efectos de los incendios forestales en la vegetación y el suelo en la cuenca mediterránea: revisión bibliográfica. Boletín de la Asociación de Geógrafos Españoles 58, 33-35 Cerdà, A, Giménez - Morera, A. Terol, E., Domínguez, A. Jurgensen, M.F., Doerr, S.H. 1999. Cultivos de cítricos y erosión de suelos en el este de la Península Ibérica. En Control de la Degradación de los suelos y cambio global (Eds: Sánchez Díaz, J., Asins Velis, S.). IV Simposio sobre control de la degradación de los suelos y cambio global. Universitat de València. Valencia. 71 - 72. Cerdà, A. 1994. Arroyada superficial en terrazas de cultivo abandonadas. El caso del País Valenciano. Cuadernos de Geografía 56, 135-154 Cerdá, A. 2007. Soil water erosion on road embankments in Eastern Spain. Science of the Total Environments 378, 151-155. González-Peñaloza, F.A., Cerdà, Zavala, L.M., Jordán, A. 2012. Do conservative agriculture practices increase soil water repellency? A case study in citrus-cropped soils. Soil & Tillage Research 124, 233 - 239. Keenleyside, C., Tucker, G.M. 2010. Farmland Abandonment in the EU: An assessment of Trend and Prospects. Report Prepared for WWF. Institute for European Environmental Policy, London. 93 pp. MacDonald, D., Crabtree, J.R., Wiesinger, G., Dax, T., Stamou, N., Fleury, P., Gutiérrez-Lazpita, J., Gibon, A. 2000. Agricultural abandonment in mountain areas of Europe: Environmental consequenses and policy reponse. Journal of Environmental Management 59, 47-69. Piqueras, J. 2012. Geografía del Territorio Valenciano. Departament de Geografia, Universitat de València (Valencia, España). 256 pp. Renwick, A., Jansson, T., Verburg, P.H., Revoredo-Giha, C., Britz, W., Gocht, A., McCracken, D. 2013. Policy reforms and agricultural land abandonment in the EU. Land Use

  6. A genomics investigation of partitioning into and among flavonoid-derived condensed tannins for carbon sequestration in Populus

    SciTech Connect

    Harding, Scott, A; Tsai, Chung-jui; Lindroth, Richard, L

    2013-03-24

    , Canada Work on the design of some of the constructs for the CT transgenics work has been published: Luo K, Harding SA, Tsai C-J (2008) A modified T-vector for simplified assembly of hairpin RNAi constructs. Biotechnology Letters 30: 1271-1274. DOE support from this project was also acknowledged in a book chapter: Douglas CJ, Ehlting J, Harding SA (2009) Phenylpropanoid and Phenolic Metabolism in Populus: Gene Family Structure and Comparative and Functional Genomics In Joshi, C.P., and S.P. DiFazio (eds). Genetics, Genomics and Breeding of Crop Plants: Poplar. Science Publishers, Enfield, New Hampshire. Pp. 304-326 Other work directly related to and supported in part by this project include: Qin H, Feng T, Harding SA, Tsai C-J, Zhang S (2008) An efficient method to identify differentially expressed genes in microarray experiments. Bioinformatics 24: 1583-1589. Tsai C-J, Ranjan P, DiFazio SP, Tuskan GA, Johnson V (2011) Poplar genome microarrays. In: Joshi CP, DiFazio SP and Kole C (eds), Genetics, Genomics and Breeding of Poplars. Science Publishers, Enfield, NH. pp. 112-127. Street N, Tsai C-J (2010) Populus resources and bioinformatics. In: Jansson S, Bhalerao R, and Groover AT (eds), Genetics and Genomics of Populus. Plant Genetics and Genomics: Crops and Models book series. Springer, New York, pp. 135-152.