Austempered ductile iron (ADI) for railroad wheels : final report.

DOT National Transportation Integrated Search

2017-01-31

The purpose of this project is to investigate the potential for austempered ductile iron (ADI) to be used as an alternative material for the production of rail wheels, which are currently cast or forged steel which is commonly heat treated. ADI has s...

Effect of austempering temperature on cavitation behaviour of unalloyed ADI material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dojcinovic, Marina; Eric, Olivera; Rajnovic, Dragan

2013-08-15

This paper provides an in-depth study and description of cavitation damage and microstructural changes in two types of unalloyed austempered ductile iron (ADI). ADI materials used were austempered at 300 and 400 °C having ausferrite microstructure with 16 and 31.4% of retained austenite, respectively. Metallographic examination was carried out to study the morphology of their cavitation-damaged surfaces. Cavitation damage was initiated at graphite nodules as well as in the interface between a graphite nodule and an ausferrite matrix. Furthermore, microcracking and ferrite/retained austenite morphology were proved to be of great importance for cavitation resistance. Mass loss rate revealed that ADImore » austempered at 400 °C has a higher cavitation resistance in water than ADI austempered at 300 °C. A higher amount of retained austenite in ADI austempered at 400 °C played an important role in increasing cavitation resistance. The good cavitation behaviour of ADI austempered at 400 °C was due to the matrix hardening by stress assisted phase transformation of retained austenite into martensite (SATRAM) phenomenon, as shown by X-ray diffraction analysis. - Highlights: • Cavitation rate of two ADI materials was tested. • ADI material with a lower hardness has had a lower cavitation rate. • The main reason is microstructural transformations during cavitation. • SATRAM phenomenon increases cavitation resistance.« less

LiDAR Applications in Resource Geology and Benefits for Land Management

NASA Astrophysics Data System (ADS)

Mikulovsky, R. P.; De La Fuente, J. A.

2013-12-01

The US Forest Service (US Department of Agriculture) manages a broad range of geologic resources and hazards on National Forests and Grass Lands throughout the United States. Resources include rock and earth materials, groundwater, caves and paleontological resources, minerals, energy resources, and unique geologic areas. Hazards include landslides, floods, earthquakes, volcanic eruptions, and naturally hazardous materials (e.g., asbestos, radon). Forest Service Geologists who address these issues are Resource Geologists. They have been exploring LiDAR as a revolutionary tool to efficiently manage all of these hazards and resources. However, most LiDAR applications for management have focused on timber and fuels management, rather than landforms. This study shows the applications and preliminary results of using LiDAR for managing geologic resources and hazards on public lands. Applications shown include calculating sediment budgets, mapping and monitoring landslides, mapping and characterizing borrow pits or mines, determining landslide potential, mapping faults, and characterizing groundwater dependent ecosystems. LiDAR can be used to model potential locations of groundwater dependent ecosystems with threatened or endangered plant species such as Howellia aquatilis. This difficult to locate species typically exists on the Mendocino National Forest within sag ponds on landslide benches. LiDAR metrics of known sites are used to model potential habitat. Thus LiDAR can link the disciplines of geology, hydrology, botany, archaeology and others for enhanced land management. As LiDAR acquisition costs decrease and it becomes more accessible, land management organizations will find a wealth of applications with potential far-reaching benefits for managing geologic resources and hazards.

Calculation of the overlap factor for scanning LiDAR based on the tridimensional ray-tracing method.

PubMed

Chen, Ruiqiang; Jiang, Yuesong; Wen, Luhong; Wen, Donghai

2017-06-01

The overlap factor is used to evaluate the LiDAR light collection ability. Ranging LiDAR is mainly determined by the optical configuration. However, scanning LiDAR, equipped with a scanning mechanism to acquire a 3D coordinate points cloud for a specified target, is essential in considering the scanning effect at the same time. Otherwise, scanning LiDAR will reduce the light collection ability and even cannot receive any echo. From this point of view, we propose a scanning LiDAR overlap factor calculation method based on the tridimensional ray-tracing method, which can be applied to scanning LiDAR with any special laser intensity distribution, any type of telescope (reflector, refractor, or mixed), and any shape obstruction (i.e., the reflector of a coaxial optical system). A case study for our LiDAR with a scanning mirror is carried out, and a MATLAB program is written to analyze the laser emission and reception process. Sensitivity analysis is carried out as a function of scanning mirror rotation speed and detector position, and the results guide how to optimize the overlap factor for our LiDAR. The results of this research will have a guiding significance in scanning LiDAR design and assembly.

Clinical Validity of the ADI-R in a US-Based Latino Population

ERIC Educational Resources Information Center

Vanegas, Sandra B.; Magaña, Sandra; Morales, Miguel; McNamara, Ellyn

2016-01-01

The Autism Diagnostic Interview-Revised (ADI-R) has been validated as a tool to aid in the diagnosis of Autism; however, given the growing diversity in the United States, the ADI-R must be validated for different languages and cultures. This study evaluates the validity of the ADI-R in a US-based Latino, Spanish-speaking population of 50 children…

RIS4E at Kilauea's December 1974 Flow: Lava Flow Texture LiDAR Signatures

NASA Astrophysics Data System (ADS)

Whelley, P.; Garry, W. B.; Scheidt, S. P.; Bleacher, J. E.; Hamilton, C.

2015-12-01

High-resolution point clouds and digital terrain models (DTMs) are used to investigate lava textures on the Big Island of Hawaii. Lava texture (e.g., ´áā and pāhoehoe) depends significantly on eruption conditions, and it is therefore instructive, if accurately determined. In places where field investigations are prohibitive (e.g., on other planets and remote regions of Earth) lava texture must be assessed from remote sensing data. A reliable method for doing so remains elusive. The December 1974 flow from Kilauea, in the Kau desert, presents an excellent field site to develop techniques for identifying lava texture. The eruption is young and the textures are well preserved. We present results comparing properties of lava textures observed in Terrestrial Laser Scanning (TLS) data. The authors collected the TLS data during May 2014 and June 2015 field seasons. Scans are a quantitative representation of what a geologist, or robotic system, sees "on the ground" and provides "ground truth" for airborne or orbital remote sensing analysis by enabling key parameters of lava morphology to be quantified. While individual scans have a heterogeneous point density, multiple scans are merged such that sub-cm lava textures can be quantified. Results indicate that TLS-derived surface roughness (i.e., de-trended RMS roughness) is useful for differentiating lava textures and assists volcanologic interpretations. As many lava types are quite rough, it is not simply roughness that is the most advantageous parameter for differentiating lava textures; rather co-occurrence patterns in surface roughness are used. Gradually forming textures (e.g., pāhoehoe) are elevated in statistics that measure smoothness (e.g., homogeneity) while lava with disrupted crusts (e.g., slabby and platy flow) have more random distributions of roughness (i.e., high entropy). A similar technique will be used to analyze high-resolution DTMs of martian lava flows using High Resolution Imaging Science

elecTUM: Umsetzung der eLearning-Strategie der Technischen Universität München

NASA Astrophysics Data System (ADS)

Rathmayer, Sabine; Gergintchev, Ivan

An der TUM wurde ein umfassendes und integriertes eLearning-Konzept umgesetzt, welches Präsenzstudium und eLearning in allen Leistungsbereichen der Universität miteinander verzahnt. Ein besonderer Schwerpunkt lag dabei in der Schaffung einer effizienten und wettbewerbsfähigen integrierten eLearning Infrastruktur in Hinblick auf die noch weiter steigenden Studienanfängerzahlen ab dem Jahr 2011 sowie die Umsetzung von eBologna. Die Etablierung einer hochschulweiten Lernplattform stellte eine wesentliche Basis für die Umsetzung der eLearning-Strategie dar. Die wissenschaftliche und wirtschaftliche Anschlussfähigkeit im Hinblick auf eine Verwertung der Projektergebnisse wurde durch die aktive Beteiligung an einer Vielzahl hochschulübergreifender Arbeitskreise, Fachtagungen und Kooperationen, vor allem über Organisations- und Dienstleistungsmodelle sowie innovative technische Entwicklungen, sichergestellt.

Test of the Angle Detecting Inclined Sensor (ADIS) Technique for Measuring Space Radiation

NASA Astrophysics Data System (ADS)

Connell, J. J.; Lopate, C.; McLaughlin, K. R.

2008-12-01

In February 2008 we exposed an Angle Detecting Inclined Sensor (ADIS) prototype to beams of 150 MeV/u 78Kr and fragments at the National Superconducting Cyclotron Laboratory's (NSCL) Coupled Cyclotron Facility (CCF). ADIS is a highly innovative and uniquely simple detector configuration used to determine the angles of incidence of heavy ions in energetic charged particle instruments. Corrections for angle of incidence are required for good charge and mass separation. An ADIS instrument is under development to fly on the GOES-R series of weather satellites. The prototype tested consisted of three ADIS detectors, two of which were inclined at an angle to the telescope axis, forming the initial detectors in a five-detector telescope stack. By comparing the signals from the ADIS detectors, the angle of incidence may be determined and a pathlength correction applied to charge and mass determinations. Thus, ADIS replaces complex position sensing detectors with a system of simple, reliable and robust Si detectors. Accelerator data were taken at multiple angles to both primary and secondary beams with a spread of energies. This test instrument represents an improvement over the previous ADIS prototype in that it used oval inclined detectors and a much lower-mass support structure, thus reducing the number of events passing through dead material. We will present the results of this test. The ADIS instrument development project was partially funded by NASA under the Living With a Star (LWS) Targeted Research and Technology program (grant NAG5-12493).

Line-Based Registration of Panoramic Images and LiDAR Point Clouds for Mobile Mapping.

PubMed

Cui, Tingting; Ji, Shunping; Shan, Jie; Gong, Jianya; Liu, Kejian

2016-12-31

For multi-sensor integrated systems, such as the mobile mapping system (MMS), data fusion at sensor-level, i.e., the 2D-3D registration between an optical camera and LiDAR, is a prerequisite for higher level fusion and further applications. This paper proposes a line-based registration method for panoramic images and a LiDAR point cloud collected by a MMS. We first introduce the system configuration and specification, including the coordinate systems of the MMS, the 3D LiDAR scanners, and the two panoramic camera models. We then establish the line-based transformation model for the panoramic camera. Finally, the proposed registration method is evaluated for two types of camera models by visual inspection and quantitative comparison. The results demonstrate that the line-based registration method can significantly improve the alignment of the panoramic image and the LiDAR datasets under either the ideal spherical or the rigorous panoramic camera model, with the latter being more reliable.

Line-Based Registration of Panoramic Images and LiDAR Point Clouds for Mobile Mapping

PubMed Central

Cui, Tingting; Ji, Shunping; Shan, Jie; Gong, Jianya; Liu, Kejian

2016-01-01

For multi-sensor integrated systems, such as the mobile mapping system (MMS), data fusion at sensor-level, i.e., the 2D-3D registration between an optical camera and LiDAR, is a prerequisite for higher level fusion and further applications. This paper proposes a line-based registration method for panoramic images and a LiDAR point cloud collected by a MMS. We first introduce the system configuration and specification, including the coordinate systems of the MMS, the 3D LiDAR scanners, and the two panoramic camera models. We then establish the line-based transformation model for the panoramic camera. Finally, the proposed registration method is evaluated for two types of camera models by visual inspection and quantitative comparison. The results demonstrate that the line-based registration method can significantly improve the alignment of the panoramic image and the LiDAR datasets under either the ideal spherical or the rigorous panoramic camera model, with the latter being more reliable. PMID:28042855

Delineation of peatland lagg boundaries from airborne LiDAR

NASA Astrophysics Data System (ADS)

Langlois, Melanie N.; Richardson, Murray C.; Price, Jonathan S.

2017-09-01

In Canada, peatlands are the most common type of wetland, but boundary delineation in peatland complexes has received little attention in the scientific literature. Typically, peatland boundaries are mapped as crisp, absolute features, and the transitional lagg zone—the ecotone found between a raised bog and the surrounding mineral land—is often overlooked. In this study, we aim (1) to advance existing approaches for detecting and locating laggs and lagg boundaries using airborne LiDAR surveys and (2) to describe the spatial distribution of laggs around raised bog peatlands. Two contrasting spatial analytical approaches for lagg detection were tested using five LiDAR-derived topographic and vegetation indices: topography, vegetation height, topographic wetness index, the standard deviation of the vegetation's height (as a proxy for the complexity of the vegetation's structure), and local indices of elevation variance. Using a dissimilarity approach (edge-detection, split-moving window analysis), no one variable accurately depicted both the lagg-mineral land and bog-lagg boundaries. Some indicators were better at predicting the bog-lagg boundary (i.e., vegetation height) and others at finding the lagg-mineral land boundary (i.e., topography). Dissimilarity analysis reinforces the usefulness of derived variables (e.g., wetness indices) in locating laggs, especially for those with weak topographic and vegetation gradients. When the lagg was confined between the bog and the adjacent upland, it took a linear form, parallel to the peatland's edge and was easier to predict. When the adjacent mineral land was flat or sloping away from the peatland, the lagg was discontinuous and intermittent and more difficult to predict.

Clinical Validity of the ADI-R in a US-Based Latino Population.

PubMed

Vanegas, Sandra B; Magaña, Sandra; Morales, Miguel; McNamara, Ellyn

2016-05-01

The Autism Diagnostic Interview-Revised (ADI-R) has been validated as a tool to aid in the diagnosis of Autism; however, given the growing diversity in the United States, the ADI-R must be validated for different languages and cultures. This study evaluates the validity of the ADI-R in a US-based Latino, Spanish-speaking population of 50 children and adolescents with ASD and developmental disability. Sensitivity and specificity of the ADI-R as a diagnostic tool were moderate, but lower than previously reported values. Validity of the social reciprocity and restrictive and repetitive behaviors domains was high, but low in the communication domain. Findings suggest that language discordance between caregiver and child may influence reporting of communication symptoms and contribute to lower sensitivity and specificity.

Reduction of image-based ADI-to-AEI overlay inconsistency with improved algorithm

NASA Astrophysics Data System (ADS)

Chen, Yen-Liang; Lin, Shu-Hong; Chen, Kai-Hsiung; Ke, Chih-Ming; Gau, Tsai-Sheng

2013-04-01

In image-based overlay (IBO) measurement, the measurement quality of various measurement spectra can be judged by quality indicators and also the ADI-to-AEI similarity to determine the optimum light spectrum. However we found some IBO measured results showing erroneous indication of wafer expansion from the difference between the ADI and the AEI maps, even after their measurement spectra were optimized. To reduce this inconsistency, an improved image calculation algorithm is proposed in this paper. Different gray levels composed of inner- and outer-box contours are extracted to calculate their ADI overlay errors. The symmetry of intensity distribution at the thresholds dictated by a range of gray levels is used to determine the particular gray level that can minimize the ADI-to-AEI overlay inconsistency. After this improvement, the ADI is more similar to AEI with less expansion difference. The same wafer was also checked by the diffraction-based overlay (DBO) tool to verify that there is no physical wafer expansion. When there is actual wafer expansion induced by large internal stress, both the IBO and the DBO measurements indicate similar expansion results. The scanning white-light interference microscope was used to check the variation of wafer warpage during the ADI and AEI stages. It predicts a similar trend with the overlay difference map, confirming the internal stress.

Flying Under the LiDAR: Relating Forest Structure to Bat Community Diversity

NASA Astrophysics Data System (ADS)

Swanson, A. C.; Weishampel, J. F.

2015-12-01

Bats are important to many ecological processes such as pollination, insect (and by proxy, disease) control, and seed dispersal and can be used to monitor ecosystem health. However, they are facing unprecedented extinction risks from habitat degradation as well as pressures from pathogens (e.g., white-nose syndrome) and wind turbines. LiDAR allows ecologists to measure structural variables of forested landscapes with increased precision and accuracy at broader spatial scales than previously possible. This study used airborne LiDAR to classify forest habitat/canopy structure at the Ordway-Swisher Biological Station (OSBS) in north central Florida. LiDAR data were acquired by the NEON airborne observation platform in summer 2014. OSBS consists of open-canopy pine savannas, closed-canopy hardwood hammocks, and seasonally wet prairies. Multiple forest structural parameters (e.g., mean, maximum, and standard deviation of height returns) were derived from LiDAR point clouds using the USDA software program FUSION. K-means clustering was used to segregate each 5x5 m raster across the ~3765 ha OSBS area into six different clusters based on the derived canopy metrics. Cluster averages for maximum, mean, and standard deviation of return heights ranged from 0 to 19.4 m, 0 to 15.3 m, and 0 to 3.0 m, respectively. To determine the relationships among these landscape-canopy features and bat species diversity and abundances, AnaBat II bat detectors were deployed from May to September in 2015 stratified by these distinct clusters. Bat calls were recorded from sunset to sunrise during each sampling period. Species were identified using AnalookW. A statistical regression model selection approach was performed in order to evaluate how forest attributes such as understory clutter, open regions, open and closed canopy, etc. influence bat communities. This knowledge provides a deeper understanding of habitat-species interactions to better manage survival of these species.

Quantifying tropical dry forest type and succession: substantial improvement with LiDAR

Treesearch

Sebastian Martinuzzi; William A. Gould; Lee A. Vierling; Andrew T. Hudak; Ross F. Nelson; Jeffrey S. Evans

2012-01-01

Improved technologies are needed to advance our knowledge of the biophysical and human factors influencing tropical dry forests, one of the world’s most threatened ecosystems. We evaluated the use of light detection and ranging (LiDAR) data to address two major needs in remote sensing of tropical dry forests, i.e., classification of forest types and delineation of...

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

PubMed

Rong, Liwei; Livingstone, Mark; Sukarieh, Rami; Petroulakis, Emmanuel; Gingras, Anne-Claude; Crosby, Katherine; Smith, Bradley; Polakiewicz, Roberto D; Pelletier, Jerry; Ferraiuolo, Maria A; Sonenberg, Nahum

2008-07-01

Eukaryotic initiation factor (eIF) 4E, the mRNA 5'-cap-binding protein, mediates the association of eIF4F with the mRNA 5'-cap structure to stimulate cap-dependent translation initiation in the cytoplasm. The assembly of eIF4E into the eIF4F complex is negatively regulated through a family of repressor proteins, called the eIF4E-binding proteins (4E-BPs). eIF4E is also present in the nucleus, where it is thought to stimulate nuclear-cytoplasmic transport of certain mRNAs. eIF4E is transported to the nucleus via its interaction with 4E-T (4E-transporter), but it is unclear how it is retained in the nucleus. Here we show that a sizable fraction (approximately 30%) of 4E-BP1 is localized to the nucleus, where it binds eIF4E. In mouse embryo fibroblasts (MEFs) subjected to serum starvation and/or rapamycin treatment, nuclear 4E-BPs sequester eIF4E in the nucleus. A dramatic loss of nuclear 4E-BP1 occurs in c-Ha-Ras-expressing MEFs, which fail to show starvation-induced nuclear accumulation of eIF4E. Therefore, 4E-BP1 is a regulator of eIF4E cellular localization.

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

PubMed Central

Rong, Liwei; Livingstone, Mark; Sukarieh, Rami; Petroulakis, Emmanuel; Gingras, Anne-Claude; Crosby, Katherine; Smith, Bradley; Polakiewicz, Roberto D.; Pelletier, Jerry; Ferraiuolo, Maria A.; Sonenberg, Nahum

2008-01-01

Eukaryotic initiation factor (eIF) 4E, the mRNA 5′-cap-binding protein, mediates the association of eIF4F with the mRNA 5′-cap structure to stimulate cap-dependent translation initiation in the cytoplasm. The assembly of eIF4E into the eIF4F complex is negatively regulated through a family of repressor proteins, called the eIF4E-binding proteins (4E-BPs). eIF4E is also present in the nucleus, where it is thought to stimulate nuclear-cytoplasmic transport of certain mRNAs. eIF4E is transported to the nucleus via its interaction with 4E-T (4E-transporter), but it is unclear how it is retained in the nucleus. Here we show that a sizable fraction (∼30%) of 4E-BP1 is localized to the nucleus, where it binds eIF4E. In mouse embryo fibroblasts (MEFs) subjected to serum starvation and/or rapamycin treatment, nuclear 4E-BPs sequester eIF4E in the nucleus. A dramatic loss of nuclear 4E-BP1 occurs in c-Ha-Ras–expressing MEFs, which fail to show starvation-induced nuclear accumulation of eIF4E. Therefore, 4E-BP1 is a regulator of eIF4E cellular localization. PMID:18515545

Students' Experiences and Challenges of Blended Learning at the University of Dar Es Salaam, Tanzania

ERIC Educational Resources Information Center

Mtebe, Joel S.; Raphael, Christina

2013-01-01

Recent developments in Information and Communication Technologies (ICTs), especially eLearning, have heightened the need for University of Dar es Salaam (UDSM) to supplement on-campus face-to-face delivery as well as meeting increased students' enrolments through blended distance learning. Since 2008, the University has been offering three…

Evaluation of the dimensions of anger reactions-5 (DAR-5) scale in combat veterans with posttraumatic stress disorder.

PubMed

Forbes, David; Alkemade, Nathan; Hopcraft, Dale; Hawthorne, Graeme; O'Halloran, Paul; Elhai, Jon D; McHugh, Tony; Bates, Glen; Novaco, Raymond W; Bryant, Richard; Lewis, Virginia

2014-12-01

After a traumatic event many people experience problems with anger which not only results in significant distress, but can also impede recovery. As such, there is value to include the assessment of anger in routine post-trauma screening procedures. The Dimensions of Anger Reactions-5 (DAR-5), as a concise measure of anger, was designed to meet such a need, its brevity minimizing the burden on client and practitioner. This study examined the psychometric properties of the DAR-5 with a sample of 163 male veterans diagnosed with Posttraumatic Stress Disorder. The DAR-5 demonstrated internal reliability (α=.86), along with convergent, concurrent and discriminant validity against a variety of established measures (e.g., HADS, PCL, STAXI). Support for the clinical cut-point score of 12 suggested by Forbes et al. (2014, Utility of the dimensions of anger reactions-5 (DAR-5) scale as a brief anger measure. Depression and Anxiety, 31, 166-173) was observed. The results support considering the DAR-5 as a preferred screening and assessment measure of problematic anger. Copyright © 2014 Elsevier Ltd. All rights reserved.

Study of the decays D0-->pi{-}e{+}nu{e}, D{0}-->K{-}e{+}nu{e}, D{+}-->pi{0}e{+}nu{e}, and D{+}-->K0e{+}nu{e}.

PubMed

Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K

2008-06-27

By using 1.8x10{6} DDpairs, we have measured B(D{0}-->pi{-}e{+}nu{e})=0.299(11)(9)%, B(D{+}-->pi{0}e{+}nu{e})=0.373(22)(13)%, B(D{0}-->K{-}e{+}nu{e})=3.56(3)(9)%, and B(D{+}-->K{0}e{+}nu{e})=8.53(13)(23)% and have studied the q;{2} dependence of the form factors. By combining our results with recent lattice calculations, we obtain |V{cd}|=0.217(9)(4)(23) and |V{cs}|=1.015(10)(11)(106).

Coastal monitoring solutions of the geomorphological response of beach-dune systems using multi-temporal LiDAR datasets (Vendée coast, France)

NASA Astrophysics Data System (ADS)

Le Mauff, Baptiste; Juigner, Martin; Ba, Antoine; Robin, Marc; Launeau, Patrick; Fattal, Paul

2018-03-01

Three beach and dune systems located in the northeastern part of the Bay of Biscay in France were monitored over 5 years with a time series of three airborne LiDAR datasets. The three study sites illustrate a variety of morphological beach types found in this region. Reproducible monitoring solutions adapted to basic and complex beach and dune morphologies using LiDAR time series were investigated over two periods bounded by the three surveys. The first period (between May 2008 and August 2010) is characterized by a higher prevalence of storm events, and thus has a greater potential for eroding the coast, than the second period (between August 2010 and September 2013). During the first period, the central and northeastern part of the Bay of Biscay was notably impacted by Storm Xynthia, with water levels and wave heights exceeding the 10-year return period and 1-year return period, respectively. Despite differences in dune morphology between the sites, the dune crest (Dhigh) and the dune base (Dlow) are efficiently extracted from each DEM. Based on the extracted dune base, an original shoreline mobility indicator is built displaying a combination of the horizontal and vertical migrations of this geomorphic indicator between two LiDAR datasets. A 'Geomorphic Change Detection' is also completed by computing DEMs of Difference (DoD) resulting in segregated maps of erosion and deposition and sediment budgets. Accounting for the accuracy of LiDAR datasets, a probabilistic approach at a 95% confidence interval is used as a threshold for the Geomorphic Change Detection showing more reliable results. However, caution should be taken when interpreting thresholded maps of changes and sediment budgets because some beach processes may be masked, especially on wide tidal beaches, by only keeping the most significant changes. The results of the shoreline mobility and Geomorphic Change Detection show a high variability in the beach responses between and within the three study

G-LiHT: Goddard's LiDAR, Hyperspectral and Thermal Airborne Imager

NASA Technical Reports Server (NTRS)

Cook, Bruce; Corp, Lawrence; Nelson, Ross; Morton, Douglas; Ranson, Kenneth J.; Masek, Jeffrey; Middleton, Elizabeth

2012-01-01

Scientists at NASA's Goddard Space Flight Center have developed an ultra-portable, low-cost, multi-sensor remote sensing system for studying the form and function of terrestrial ecosystems. G-LiHT integrates two LIDARs, a 905 nanometer single beam profiler and 1550 nm scanner, with a narrowband (1.5 nanometers) VNIR imaging spectrometer and a broadband (8-14 micrometers) thermal imager. The small footprint (approximately 12 centimeters) LIDAR data and approximately 1 meter ground resolution imagery are advantageous for high resolution applications such as the delineation of canopy crowns, characterization of canopy gaps, and the identification of sparse, low-stature vegetation, which is difficult to detect from space-based instruments and large-footprint LiDAR. The hyperspectral and thermal imagery can be used to characterize species composition, variations in biophysical variables (e.g., photosynthetic pigments), surface temperature, and responses to environmental stressors (e.g., heat, moisture loss). Additionally, the combination of LIDAR optical, and thermal data from G-LiHT is being used to assess forest health by sensing differences in foliage density, photosynthetic pigments, and transpiration. Low operating costs (approximately $1 ha) have allowed us to evaluate seasonal differences in LiDAR, passive optical and thermal data, which provides insight into year-round observations from space. Canopy characteristics and tree allometry (e.g., crown height:width, canopy:ground reflectance) derived from G-LiHT data are being used to generate realistic scenes for radiative transfer models, which in turn are being used to improve instrument design and ensure continuity between LiDAR instruments. G-LiHT has been installed and tested in aircraft with fuselage viewports and in a custom wing-mounted pod that allows G-LiHT to be flown on any Cessna 206, a common aircraft in use throughout the world. G-LiHT is currently being used for forest biomass and growth estimation

Object-based habitat mapping using very high spatial resolution multispectral and hyperspectral imagery with LiDAR data

NASA Astrophysics Data System (ADS)

Onojeghuo, Alex Okiemute; Onojeghuo, Ajoke Ruth

2017-07-01

This study investigated the combined use of multispectral/hyperspectral imagery and LiDAR data for habitat mapping across parts of south Cumbria, North West England. The methodology adopted in this study integrated spectral information contained in pansharp QuickBird multispectral/AISA Eagle hyperspectral imagery and LiDAR-derived measures with object-based machine learning classifiers and ensemble analysis techniques. Using the LiDAR point cloud data, elevation models (such as the Digital Surface Model and Digital Terrain Model raster) and intensity features were extracted directly. The LiDAR-derived measures exploited in this study included Canopy Height Model, intensity and topographic information (i.e. mean, maximum and standard deviation). These three LiDAR measures were combined with spectral information contained in the pansharp QuickBird and Eagle MNF transformed imagery for image classification experiments. A fusion of pansharp QuickBird multispectral and Eagle MNF hyperspectral imagery with all LiDAR-derived measures generated the best classification accuracies, 89.8 and 92.6% respectively. These results were generated with the Support Vector Machine and Random Forest machine learning algorithms respectively. The ensemble analysis of all three learning machine classifiers for the pansharp QuickBird and Eagle MNF fused data outputs did not significantly increase the overall classification accuracy. Results of the study demonstrate the potential of combining either very high spatial resolution multispectral or hyperspectral imagery with LiDAR data for habitat mapping.

Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells.

PubMed

Manca, Antonella; Sini, Maria Cristina; Izzo, Francesco; Ascierto, Paolo A; Tatangelo, Fabiana; Botti, Gerardo; Gentilcore, Giusy; Capone, Marilena; Mozzillo, Nicola; Rozzo, Carla; Cossu, Antonio; Tanda, Francesco; Palmieri, Giuseppe

2011-06-01

Arginine deiminase (ADI), an arginine-degrading enzyme, has been used in the treatment of tumours sensitive to arginine deprivation, such as malignant melanoma (MM) and hepatocellular carcinoma (HCC). Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes. We evaluated the effect of ADI treatment on OTC and ASS expression in a series of melanoma cell lines. Twenty-five primary melanoma cell lines and normal fibroblasts as controls underwent cell proliferation assays and Western blot analyses in the presence or absence of ADI. Tissue sections from primary MMs (N = 20) and HCCs (N = 20) were investigated by immunohistochemistry for ASS expression. Overall, 21/25 (84%) MM cell lines presented a cell growth inhibition by ADI treatment; none of them presented constitutive detectable levels of the ASS protein. However, 7/21 (33%) ADI-sensitive melanoma cell lines presented markedly increased expression levels of the ASS protein following ADI treatment, with a significantly higher IC50 median value. Growth was not inhibited and the IC50 was not reached among the remaining 4/25 (16%) MM cell lines; all of them showed constitutive ASS expression. The OTC protein was found expressed in all melanoma cell lines before and after the ADI treatment. Lack of ASS immunostaining was observed in all analyzed in vivo specimens. Our findings suggest that response to ADI treatment in melanoma is significantly correlated with the ability of cells to express ASS either constitutively at basal level (inducing drug resistance) or after the treatment (reducing sensitivity to ADI).

Simulation of Satellite, Airborne and Terrestrial LiDAR with DART (I):Waveform Simulation with Quasi-Monte Carlo Ray Tracing

NASA Technical Reports Server (NTRS)

Gastellu-Etchegorry, Jean-Philippe; Yin, Tiangang; Lauret, Nicolas; Grau, Eloi; Rubio, Jeremy; Cook, Bruce D.; Morton, Douglas C.; Sun, Guoqing

2016-01-01

Light Detection And Ranging (LiDAR) provides unique data on the 3-D structure of atmosphere constituents and the Earth's surface. Simulating LiDAR returns for different laser technologies and Earth scenes is fundamental for evaluating and interpreting signal and noise in LiDAR data. Different types of models are capable of simulating LiDAR waveforms of Earth surfaces. Semi-empirical and geometric models can be imprecise because they rely on simplified simulations of Earth surfaces and light interaction mechanisms. On the other hand, Monte Carlo ray tracing (MCRT) models are potentially accurate but require long computational time. Here, we present a new LiDAR waveform simulation tool that is based on the introduction of a quasi-Monte Carlo ray tracing approach in the Discrete Anisotropic Radiative Transfer (DART) model. Two new approaches, the so-called "box method" and "Ray Carlo method", are implemented to provide robust and accurate simulations of LiDAR waveforms for any landscape, atmosphere and LiDAR sensor configuration (view direction, footprint size, pulse characteristics, etc.). The box method accelerates the selection of the scattering direction of a photon in the presence of scatterers with non-invertible phase function. The Ray Carlo method brings traditional ray-tracking into MCRT simulation, which makes computational time independent of LiDAR field of view (FOV) and reception solid angle. Both methods are fast enough for simulating multi-pulse acquisition. Sensitivity studies with various landscapes and atmosphere constituents are presented, and the simulated LiDAR signals compare favorably with their associated reflectance images and Laser Vegetation Imaging Sensor (LVIS) waveforms. The LiDAR module is fully integrated into DART, enabling more detailed simulations of LiDAR sensitivity to specific scene elements (e.g., atmospheric aerosols, leaf area, branches, or topography) and sensor configuration for airborne or satellite LiDAR sensors.

Modelling vertical error in LiDAR-derived digital elevation models

NASA Astrophysics Data System (ADS)

Aguilar, Fernando J.; Mills, Jon P.; Delgado, Jorge; Aguilar, Manuel A.; Negreiros, J. G.; Pérez, José L.

2010-01-01

A hybrid theoretical-empirical model has been developed for modelling the error in LiDAR-derived digital elevation models (DEMs) of non-open terrain. The theoretical component seeks to model the propagation of the sample data error (SDE), i.e. the error from light detection and ranging (LiDAR) data capture of ground sampled points in open terrain, towards interpolated points. The interpolation methods used for infilling gaps may produce a non-negligible error that is referred to as gridding error. In this case, interpolation is performed using an inverse distance weighting (IDW) method with the local support of the five closest neighbours, although it would be possible to utilize other interpolation methods. The empirical component refers to what is known as "information loss". This is the error purely due to modelling the continuous terrain surface from only a discrete number of points plus the error arising from the interpolation process. The SDE must be previously calculated from a suitable number of check points located in open terrain and assumes that the LiDAR point density was sufficiently high to neglect the gridding error. For model calibration, data for 29 study sites, 200×200 m in size, belonging to different areas around Almeria province, south-east Spain, were acquired by means of stereo photogrammetric methods. The developed methodology was validated against two different LiDAR datasets. The first dataset used was an Ordnance Survey (OS) LiDAR survey carried out over a region of Bristol in the UK. The second dataset was an area located at Gador mountain range, south of Almería province, Spain. Both terrain slope and sampling density were incorporated in the empirical component through the calibration phase, resulting in a very good agreement between predicted and observed data (R2 = 0.9856 ; p < 0.001). In validation, Bristol observed vertical errors, corresponding to different LiDAR point densities, offered a reasonably good fit to the predicted

Study of the semileptonic charm decays D0→π-e+νe, D+→π0e+νe, D0→K-e+νe, and D+→ Kmacr 0e+νe

NASA Astrophysics Data System (ADS)

Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Severini, H.; Dytman, S. A.; Love, W.; Savinov, V.; Aquines, O.; Li, Z.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Coan, T. E.; Gao, Y. S.; Liu, F.; Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Redjimi, R.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Csorna, S. E.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Briere, R. A.; Brock, I.; Chen, J.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Berkelman, K.; Cassel, D. G.; Duboscq, J. E.; Ecklund, K. M.; Ehrlich, R.; Fields, L.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Weinberger, M.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E. J.; Wiss, J.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.; Gao, K. Y.; Gong, D. T.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.

2008-06-01

Using a sample of 1.8 million D Dmacr mesons collected at the ψ(3770) with the CLEO-c detector, we study the semileptonic decays D0→π-e+νe, D+→π0e+νe, D0→K-e+νe, and D+→ Kmacr 0e+νe. For the total branching fractions we find B(D0→π-e+νe)=0.299(11)(9)%, B(D+→π0e+νe)=0.373(22)(13)%, B(D0→K-e+νe)=3.56(3)(9)%, and B(D+→ Kmacr 0e+νe)=8.53(13)(23)%, where the first error is statistical and the second systematic. In addition, form factors are studied through fits to the partial branching fractions obtained in five q2 ranges. By combining our results with recent unquenched lattice calculations, we obtain |Vcd|=0.217(9)(4)(23) and |Vcs|=1.015(10)(11)(106), where the final error is theoretical.

Study of the Decays D0→π-e+νe, D0→K-e+νe, D+→π0e+νe, and D+→ Kmacr 0e+νe

NASA Astrophysics Data System (ADS)

Cronin-Hennessy, D.; Gao, K. Y.; Gong, D. T.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Severini, H.; Dytman, S. A.; Love, W.; Savinov, V.; Aquines, O.; Li, Z.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Coan, T. E.; Gao, Y. S.; Liu, F.; Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Redjimi, R.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Csorna, S. E.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Briere, R. A.; Brock, I.; Chen, J.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Berkelman, K.; Cassel, D. G.; Duboscq, J. E.; Ecklund, K. M.; Ehrlich, R.; Fields, L.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Weinberger, M.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E. J.; Wiss, J.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.

2008-06-01

By using 1.8×106 D Dmacr pairs, we have measured B(D0→π-e+νe)=0.299(11)(9)%, B(D+→π0e+νe)=0.373(22)(13)%, B(D0→K-e+νe)=3.56(3)(9)%, and B(D+→ Kmacr 0e+νe)=8.53(13)(23)% and have studied the q2 dependence of the form factors. By combining our results with recent lattice calculations, we obtain |Vcd|=0.217(9)(4)(23) and |Vcs|=1.015(10)(11)(106).

E2E: A Summary of the e2e Learning Framework.

ERIC Educational Resources Information Center

Learning and Skills Development Agency, London (England).

This publication is a summary of the E2E (Entry to Employment) Learning Framework that provides guidance on program implementation. (E2E is a new learning program for young people not yet ready or able to enter Modern Apprenticeship programs, a Level 2 program, or employment directly.) Section 2 highlights core values to which all involved should…

Buildings classification from airborne LiDAR point clouds through OBIA and ontology driven approach

NASA Astrophysics Data System (ADS)

Tomljenovic, Ivan; Belgiu, Mariana; Lampoltshammer, Thomas J.

2013-04-01

the consistency of the developed ontologies, and logical reasoning is performed to infer implicit relations between defined concepts. The ontology for the definition of building is specified using the Ontology Web Language (OWL). It is the most widely used ontology language that is based on Description Logics (DL). DL allows the description of internal properties of modelled concepts (roof typology, shape, area, height etc.) and relationships between objects (IS_A, MEMBER_OF/INSTANCE_OF). It captures terminological knowledge (TBox) as well as assertional knowledge (ABox) - that represents facts about concept instances, i.e. the buildings in airborne LiDAR data. To assess the classification accuracy, ground truth data generated by visual interpretation and calculated classification results in terms of precision and recall are used. The advantages of this approach are: (i) flexibility, (ii) transferability, and (iii) extendibility - i.e. ontology can be extended with further concepts, data properties and object properties.

Perturbative QCD analysis of exclusive processes e+e-→V P and e+e-→T P

NASA Astrophysics Data System (ADS)

Lü, Cai-Dian; Wang, Wei; Xing, Ye; Zhang, Qi-An

2018-06-01

We study the e+e-→V P and e+e-→T P processes in the perturbative QCD approach based on kT factorization, where the P , V and T denotes a light pseudoscalar, vector, and tensor meson, respectively. We point out in the case of e+e-→T P transition due to charge conjugation invariance, only three channels are allowed: e+e-→a2±π∓ , e+e-→K2*±K∓ and the V-spin suppressed e+e-→K2*0K¯ 0+K¯2 *0K0 . Cross sections of e+e-→V P and e+e-→T P at √{s }=3.67 GeV and √{s }=10.58 GeV are calculated and the invariant mass dependence is found to favor the 1 /s4 power law. Most of our theoretical results are consistent with the available experimental data and other predictions can be tested at the ongoing BESIII and forthcoming Belle-II experiments.

Perfectly matched layers in a divergence preserving ADI scheme for electromagnetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, C.; ETH Zurich, Chair of Computational Science, 8092 Zuerich; Adelmann, A., E-mail: andreas.adelmann@psi.ch

For numerical simulations of highly relativistic and transversely accelerated charged particles including radiation fast algorithms are needed. While the radiation in particle accelerators has wavelengths in the order of 100 {mu}m the computational domain has dimensions roughly five orders of magnitude larger resulting in very large mesh sizes. The particles are confined to a small area of this domain only. To resolve the smallest scales close to the particles subgrids are envisioned. For reasons of stability the alternating direction implicit (ADI) scheme by Smithe et al. [D.N. Smithe, J.R. Cary, J.A. Carlsson, Divergence preservation in the ADI algorithms for electromagnetics,more » J. Comput. Phys. 228 (2009) 7289-7299] for Maxwell equations has been adopted. At the boundary of the domain absorbing boundary conditions have to be employed to prevent reflection of the radiation. In this paper we show how the divergence preserving ADI scheme has to be formulated in perfectly matched layers (PML) and compare the performance in several scenarios.« less

Genomic Characterization of DArT Markers Based on High-Density Linkage Analysis and Physical Mapping to the Eucalyptus Genome

PubMed Central

Petroli, César D.; Sansaloni, Carolina P.; Carling, Jason; Steane, Dorothy A.; Vaillancourt, René E.; Myburg, Alexander A.; da Silva, Orzenil Bonfim; Pappas, Georgios Joannis; Kilian, Andrzej; Grattapaglia, Dario

2012-01-01

Diversity Arrays Technology (DArT) provides a robust, high throughput, cost-effective method to query thousands of sequence polymorphisms in a single assay. Despite the extensive use of this genotyping platform for numerous plant species, little is known regarding the sequence attributes and genome-wide distribution of DArT markers. We investigated the genomic properties of the 7,680 DArT marker probes of a Eucalyptus array, by sequencing them, constructing a high density linkage map and carrying out detailed physical mapping analyses to the Eucalyptus grandis reference genome. A consensus linkage map with 2,274 DArT markers anchored to 210 microsatellites and a framework map, with improved support for ordering, displayed extensive collinearity with the genome sequence. Only 1.4 Mbp of the 75 Mbp of still unplaced scaffold sequence was captured by 45 linkage mapped but physically unaligned markers to the 11 main Eucalyptus pseudochromosomes, providing compelling evidence for the quality and completeness of the current Eucalyptus genome assembly. A highly significant correspondence was found between the locations of DArT markers and predicted gene models, while most of the 89 DArT probes unaligned to the genome correspond to sequences likely absent in E. grandis, consistent with the pan-genomic feature of this multi-Eucalyptus species DArT array. These comprehensive linkage-to-physical mapping analyses provide novel data regarding the genomic attributes of DArT markers in plant genomes in general and for Eucalyptus in particular. DArT markers preferentially target the gene space and display a largely homogeneous distribution across the genome, thereby providing superb coverage for mapping and genome-wide applications in breeding and diversity studies. Data reported on these ubiquitous properties of DArT markers will be particularly valuable to researchers working on less-studied crop species who already count on DArT genotyping arrays but for which no reference

76 FR 36121 - Recent Posting to the Applicability Determination Index (ADI) Database System of Agency...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

..., and regulatory interpretations, and posts them on the ADI on a quarterly basis. In addition, the ADI... NSPS A, AAa Installation of a Capacitor Bank and Tuned Reactor 1000019 NSPS AAAA Conversion of Post... WWW Amended Design Capacity Reports A100001 Asbestos M Removal of Asbestos Containing Coating...

Using Satellite and Airborne LiDAR to Model Woodpecker Habitat Occupancy at the Landscape Scale

PubMed Central

Vierling, Lee A.; Vierling, Kerri T.; Adam, Patrick; Hudak, Andrew T.

2013-01-01

Incorporating vertical vegetation structure into models of animal distributions can improve understanding of the patterns and processes governing habitat selection. LiDAR can provide such structural information, but these data are typically collected via aircraft and thus are limited in spatial extent. Our objective was to explore the utility of satellite-based LiDAR data from the Geoscience Laser Altimeter System (GLAS) relative to airborne-based LiDAR to model the north Idaho breeding distribution of a forest-dependent ecosystem engineer, the Red-naped sapsucker (Sphyrapicus nuchalis). GLAS data occurred within ca. 64 m diameter ellipses spaced a minimum of 172 m apart, and all occupancy analyses were confined to this grain scale. Using a hierarchical approach, we modeled Red-naped sapsucker occupancy as a function of LiDAR metrics derived from both platforms. Occupancy models based on satellite data were weak, possibly because the data within the GLAS ellipse did not fully represent habitat characteristics important for this species. The most important structural variables influencing Red-naped Sapsucker breeding site selection based on airborne LiDAR data included foliage height diversity, the distance between major strata in the canopy vertical profile, and the vegetation density near the ground. These characteristics are consistent with the diversity of foraging activities exhibited by this species. To our knowledge, this study represents the first to examine the utility of satellite-based LiDAR to model animal distributions. The large area of each GLAS ellipse and the non-contiguous nature of GLAS data may pose significant challenges for wildlife distribution modeling; nevertheless these data can provide useful information on ecosystem vertical structure, particularly in areas of gentle terrain. Additional work is thus warranted to utilize LiDAR datasets collected from both airborne and past and future satellite platforms (e.g. GLAS, and the planned IceSAT2

LiDAR for data efficiency.

DOT National Transportation Integrated Search

2011-09-30

This report documents the AHMCT research project: LiDAR for Data Efficiency for the Washington State Department of Transportation (WSDOT). The research objective was to evaluate mobile LiDAR technology to enhance safety, determine efficiency ga...

Bridging gaps: On the performance of airborne LiDAR to model wood mouse-habitat structure relationships in pine forests.

PubMed

Jaime-González, Carlos; Acebes, Pablo; Mateos, Ana; Mezquida, Eduardo T

2017-01-01

LiDAR technology has firmly contributed to strengthen the knowledge of habitat structure-wildlife relationships, though there is an evident bias towards flying vertebrates. To bridge this gap, we investigated and compared the performance of LiDAR and field data to model habitat preferences of wood mouse (Apodemus sylvaticus) in a Mediterranean high mountain pine forest (Pinus sylvestris). We recorded nine field and 13 LiDAR variables that were summarized by means of Principal Component Analyses (PCA). We then analyzed wood mouse's habitat preferences using three different models based on: (i) field PCs predictors, (ii) LiDAR PCs predictors; and (iii) both set of predictors in a combined model, including a variance partitioning analysis. Elevation was also included as a predictor in the three models. Our results indicate that LiDAR derived variables were better predictors than field-based variables. The model combining both data sets slightly improved the predictive power of the model. Field derived variables indicated that wood mouse was positively influenced by the gradient of increasing shrub cover and negatively affected by elevation. Regarding LiDAR data, two LiDAR PCs, i.e. gradients in canopy openness and complexity in forest vertical structure positively influenced wood mouse, although elevation interacted negatively with the complexity in vertical structure, indicating wood mouse's preferences for plots with lower elevations but with complex forest vertical structure. The combined model was similar to the LiDAR-based model and included the gradient of shrub cover measured in the field. Variance partitioning showed that LiDAR-based variables, together with elevation, were the most important predictors and that part of the variation explained by shrub cover was shared. LiDAR derived variables were good surrogates of environmental characteristics explaining habitat preferences by the wood mouse. Our LiDAR metrics represented structural features of the forest

Evaluating UAV and LiDAR Retrieval of Snow Depth in a Coniferous Forest in Arizona

NASA Astrophysics Data System (ADS)

Van Leeuwen, W. J. D.; Broxton, P.; Biederman, J. A.

2017-12-01

Remote sensing of snow depth and cover in forested environments is challenging. Trees interfere with the remote sensing of snowpack below the canopy and cause large variations in the spatial distribution of the snowpack itself (e.g. between below canopy environments to shaded gaps to open clearings). The distribution of trees and topographic variation make it challenging to monitor the snowpack with in-situ observations. Airborne LiDAR has improved our ability to monitor snowpack over large areas in montane and forested environments because of its high sampling rate and ability to penetrate the canopy. However, these LiDAR flights can be too expensive and time-consuming to process, making it hard to use them for real-time snow monitoring. In this research, we evaluate Structure from Motion (SfM) as an alternative to Airborne LiDAR to generate high-resolution snow depth data in forested environments. This past winter, we conducted a snow field campaign over Arizona's Mogollon Rim where we acquired aerial LiDAR, multi-angle aerial photography from a UAV, and extensive field observations of snow depth at two sites. LiDAR and SFM derived snow depth maps were generated by comparing "snow-on" and "snow-off" LiDAR and SfM data. The SfM- and LiDAR-generated snow depth maps were similar at a site with fewer trees, though there were more discrepancies at a site with more trees. Both compared reasonably well with the field observations at the sparser forested site, with poorer agreement at the denser forested site. Finally, although the SfM produced point clouds with much higher point densities than the aerial LiDAR, the SfM was not able to produce meaningful snow depth estimates directly underneath trees and had trouble in areas with deep shadows. Based on these findings, we are optimizing our UAV data acquisition strategies for this upcoming field season. We are using these data, along with high-resolution hydrological modeling, to gain a better understanding of how

3D turbulence measurements in inhomogeneous boundary layers with three wind LiDARs

NASA Astrophysics Data System (ADS)

Carbajo Fuertes, Fernando; Valerio Iungo, Giacomo; Porté-Agel, Fernando

2014-05-01

One of the most challenging tasks in atmospheric anemometry is obtaining reliable turbulence measurements of inhomogeneous boundary layers at heights or in locations where is not possible or convenient to install tower-based measurement systems, e.g. mountainous terrain, cities, wind farms, etc. Wind LiDARs are being extensively used for the measurement of averaged vertical wind profiles, but they can only successfully accomplish this task under the limiting conditions of flat terrain and horizontally homogeneous flow. Moreover, it has been shown that common scanning strategies introduce large systematic errors in turbulence measurements, regardless of the characteristics of the flow addressed. From the point of view of research, there exist a variety of techniques and scanning strategies to estimate different turbulence quantities but most of them rely in the combination of raw measurements with atmospheric models. Most of those models are only valid under the assumption of horizontal homogeneity. The limitations stated above can be overcome by a new triple LiDAR technique which uses simultaneous measurements from three intersecting Doppler wind LiDARs. It allows for the reconstruction of the three-dimensional velocity vector in time as well as local velocity gradients without the need of any turbulence model and with minimal assumptions [EGU2013-9670]. The triple LiDAR technique has been applied to the study of the flow over the campus of EPFL in Lausanne (Switzerland). The results show the potential of the technique for the measurement of turbulence in highly complex boundary layer flows. The technique is particularly useful for micrometeorology and wind engineering studies.

Observation of ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ.

PubMed

Ablikim, M; Achasov, M N; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Baldini Ferroli, R; Ban, Y; Bennett, D W; Bennett, J V; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, H Y; Chen, J C; Chen, M L; Chen, S; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fedorov, O; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, X Y; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, R P; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Held, T; Heng, Y K; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, X Z; Huang, Y; Huang, Z L; Hussain, T; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, H J; Li, J C; Li, Jin; Li, K; Li, K; Li, Lei; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Y B; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, M M; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Min, J; Mitchell, R E; Mo, X H; Mo, Y J; Morales Morales, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Sarantsev, A; Savrié, M; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Shi, M; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, X H; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Ullrich, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, S G; Wang, W; Wang, W P; Wang, X F; Wang, Y; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Wang, Z Y; Weber, T; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, L J; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, J J; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, S Q; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

2017-06-02

Using 4.479×10^{8}  ψ(3686) events collected with the BESIII detector, we search for the decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ, where J=0, 1, 2. The decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ are observed for the first time. The measured branching fractions are B(ψ(3686)→e^{+}e^{-}χ_{cJ})=(11.7±2.5±1.0)×10^{-4}, (8.6±0.3±0.6)×10^{-4}, (6.9±0.5±0.6)×10^{-4} for J=0, 1, 2, and B(χ_{cJ}→e^{+}e^{-}J/ψ)=(1.51±0.30±0.13)×10^{-4}, (3.73±0.09±0.25)×10^{-3}, (2.48±0.08±0.16)×10^{-3} for J=0, 1, 2, respectively. The ratios of the branching fractions B(ψ(3686)→e^{+}e^{-}χ_{cJ})/B(ψ(3686)→γχ_{cJ}) and B(χ_{cJ}→e^{+}e^{-}J/ψ)/B(χ_{cJ}→γJ/ψ) are also reported. Also, the α values of helicity angular distributions of the e^{+}e^{-} pair are determined for ψ(3686)→e^{+}e^{-}χ_{c1,2} and χ_{c1,2}→e^{+}e^{-}J/ψ.

Coastal and tidal landform detection from high resolution topobathymetric LiDAR data

NASA Astrophysics Data System (ADS)

Skovgaard Andersen, Mikkel; Al-Hamdani, Zyad; Steinbacher, Frank; Rolighed Larsen, Laurids; Brandbyge Ernstsen, Verner

2016-04-01

Coastal and tidal environments are valuable ecosystems, which, however, are under pressure in many areas around the world due to globalisation and/or climate change. Detailed mapping of these environments is required in order to manage the coastal zone in a sustainable way. However, historically these transition zones between land and water are difficult or even impossible to map and investigate in high spatial resolution due to the challenging environmental conditions. The new generation of airborne topobathymetric light detection and ranging (LiDAR) potentially enables full-coverage and high-resolution mapping of these land-water transition zones. We have carried out topobathymetric LiDAR surveys in the Knudedyb tidal inlet system, a coastal environment in the Danish Wadden Sea which is part of the Wadden Sea National Park and UNESCO World Heritage. Detailed digital elevation models (DEMs) with a grid cell size of 0.5 m x 0.5 m were generated from the LiDAR point cloud with a mean point density in the order of 20 points/m2. The DEM was analysed morphometrically using a modification of the tool Benthic Terrain Modeler (BTM) developed by Wright et al. (2005). Initially, stage (the elevation in relation to tidal range) was used to divide the area of investigation into the different tidal zones, i.e. subtidal, intertidal and supratidal. Subsequently, morphometric units were identified and characterised by a combination of statistical neighbourhood analysis with varying window sizes (using the Bathymetric Positioning Index (BPI) from the BTM, moving average and standard deviation), slope parameters and area/perimeter ratios. Finally, these morphometric units were classified into six different types of landforms based on their stage and morphometric characteristics, i.e. either subtidal channel, intertidal flat, intertidal creek, linear bar, swash bar or beach dune. We hereby demonstrate the potential of using airborne topobathymetric LiDAR for seamless mapping of land

Job Prospects for E/E Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1986-01-01

Reviews job prospects for electrical/electronic E/E engineers, indicating that 1985 was not a banner year due to problems in the semiconductor manufacturing industries and in telecommunications. Also indicates that an upturn is expected for 1986 E/E graduates. (JN)

Radiative Correction to e+e-to e+e- in the Electroweak Theory. I --Cross Sections for Hard Photon Emission--

NASA Astrophysics Data System (ADS)

Tobimatsu, K.; Shimizu, Y.

1985-09-01

Various cross sections for radiative Bhabha scattering, e+e-to e+e-γ, are calculated in the standard electroweak theory. They contain distributions on photon energy dσ/dk, acollinearity angle dσ/dzeta, acoplanarity angle dσ/dψ, photon transverse momentum dσ/dkT and invariant mass of final e-γ system dσ/dMeγ. In the calculation some realistic experimental cuts are imposed on the configuration of final particles and the energies are chosen to be 70, 93 and 150 GeV in accordance with TRISTAN, SLC and LEP. From the results we can see the effect of Z0-boson exchanged in the s- and t-channel and estimate backgrounds to such interesting processes as e+e-toνbar{ν}γ, tilde{γ}tilde{γ}γ and e+e-to e*eto e+e-γ.

E-Cigarette Marketing and Communication: How E-Cigarette Companies Market E-Cigarettes and the Public Engages with E-cigarette Information.

PubMed

Collins, Lauren; Glasser, Allison M; Abudayyeh, Haneen; Pearson, Jennifer L; Villanti, Andrea C

2018-01-05

Given the lack of regulation on marketing of electronic cigarettes (e-cigarettes) in the U.S. and the increasing exchange of e-cigarette-related information online, it is critical to understand how e-cigarette companies market e-cigarettes and how the public engages with e-cigarette information. Results are from a systematic review of peer-reviewed literature on e-cigarettes via a PubMed search through June 1, 2017. Search terms included: "e-cigarette*" OR "electronic cigarette" OR "electronic cigarettes" OR "electronic nicotine delivery" OR "vape" OR "vaping." Experimental studies, quasi-experimental studies, observational studies, qualitative studies, and mixed methods studies providing empirical findings on e-cigarette marketing and communication (i.e., non-marketing communication in the public) were included. One hundred twenty-four publications on e-cigarette marketing and communication were identified. They covered topics including e-cigarette advertisement claims/promotions and exposure/receptivity, the effect of e-cigarette advertisements on e-cigarette and cigarette use, public engagement with e-cigarette information, and the public's portrayal of e-cigarettes. Studies show increases in e-cigarette marketing expenditures and online engagement through social media over time, that e-cigarettes are often framed as an alternative to combustible cigarettes, and that e-cigarette advertisement exposure may be associated with e-cigarette trial in adolescents and young adults. Few studies examine the effects of e-cigarette marketing on perceptions and e-cigarette and cigarette use. Evidence suggests that exposure to e-cigarette advertisements affects perceptions and trial of e-cigarettes, but there is no evidence that exposure affects cigarette use. No studies examined how exposure to e-cigarette communication, particularly misleading or inaccurate information, impacts e-cigarette and tobacco use behaviors. The present article provides a comprehensive review of e

Multi-component wind measurements of wind turbine wakes performed with three LiDARs

NASA Astrophysics Data System (ADS)

Iungo, G. V.; Wu, Y.-T.; Porté-Agel, F.

2012-04-01

Field measurements of the wake flow produced from the interaction between atmospheric boundary layer and a wind turbine are performed with three wind LiDARs. The tested wind turbine is a 2 MW Enercon E-70 located in Collonges, Switzerland. First, accuracy of mean values and frequency resolution of the wind measurements are surveyed as a function of the number of laser rays emitted for each measurement. Indeed, measurements performed with one single ray allow maximizing sampling frequency, thus characterizing wake turbulence. On the other hand, if the number of emitted rays is increased accuracy of mean wind is increased due to the longer sampling period. Subsequently, two-dimensional measurements with a single LiDAR are carried out over vertical sections of the wind turbine wake and mean wake flow is obtained by averaging 2D measurements consecutively performed. The high spatial resolution of the used LiDAR allows characterizing in details velocity defect present in the central part of the wake and its downstream recovery. Single LiDAR measurements are also performed by staring the laser beam at fixed directions for a sampling period of about ten minutes and maximizing the sampling frequency in order to characterize wake turbulence. From these tests wind fluctuation peaks are detected in the wind turbine wake at blade top-tip height for different downstream locations. The magnitude of these turbulence peaks is generally reduced by moving downstream. This increased turbulence level at blade top-tip height observed for a real wind turbine has been already detected from previous wind tunnel tests and Large Eddy simulations, thus confirming the presence of a source of dangerous fatigue loads for following wind turbines within a wind farm. Furthermore, the proper characterization of wind fluctuations through LiDAR measurements is proved by the detection of the inertial subrange from spectral analysis of these velocity signals. Finally, simultaneous measurements with two

Change detection of riverbed movements using river cross-sections and LiDAR data

NASA Astrophysics Data System (ADS)

Vetter, Michael; Höfle, Bernhard; Mandlburger, Gottfried; Rutzinger, Martin

2010-05-01

Today, Airborne LiDAR derived digital terrain models (DTMs) are used for several aspects in different scientific disciplines, such as hydrology, geomorphology or archaeology. In the field of river geomorphology, LiDAR data sets can provide information on the riverine vegetation, the level and boundary of the water body, the elevation of the riparian foreland and their roughness. The LiDAR systems in use for topographic data acquisition mainly operate with wavelengths of at least 1064nm and, thus, are not able to penetrate water. LiDAR sensors with two wavelengths are available (bathymetric LiDAR), but they can only provide elevation information of riverbeds or lakes, if the water is clear and the minimum water depth exceeds 1.5m. In small and shallow rivers it is impossible to collect information of the riverbed, regardless of the used LiDAR sensor. In this article, we present a method to derive a high-resolution DTM of the riverbed and to combine it with the LiDAR DTM resulting in a watercourse DTM (DTM-W) as a basis for calculating the changes in the riverbed during several years. To obtain such a DTM-W we use river cross-sections acquired by terrestrial survey or echo-sounding. First, a differentiation between water and land has to be done. A highly accurate water surface can be derived by using a water surface delineation algorithm, which incorporates the amplitude information of the LiDAR point cloud and additional geometrical features (e.g. local surface roughness). The second step is to calculate a thalweg line, which is the lowest flow path in the riverbed. This is achieved by extracting the lowest point of each river cross section and by fitting a B-spline curve through those points. In the next step, the centerline of the river is calculated by applying a shrinking algorithm of the water boundary polygon. By averaging the thalweg line and the centerline, a main flow path line can be computed. Subsequently, a dense array of 2D-profiles perpendicular to the

Job Prospects for E/E Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1987-01-01

Discusses the trends in employment in the electrical/electronics (E/E) engineering industry. States that although the number of E/E graduates grew at a rate of over 11 percent from 1985 to 1986, the economy continues to be the major determinant in the job outlook in the field. (TW)

On the use of airborne LiDAR for braided river monitoring and water surface delineation

NASA Astrophysics Data System (ADS)

Vetter, M.; Höfle, B.; Pfeifer, N.; Rutzinger, M.; Stötter, J.

2009-04-01

Airborne LiDAR is an established technology for Earth surface surveying. With LiDAR data sets it is possible to derive maps with different land use classes, which are important for hydraulic simulations. We present a 3D point cloud based method for automatic water surface delineation using single as well as multitemporal LiDAR data sets. With the developed method it is possible to detect the location of the water surface with high planimetric accuracy. The multitemporal analysis of different LiDAR data sets makes it possible to visualize, monitor and quantify the changes of the flow path of braided rivers as well as derived water surface land use classes. The reflection properties from laser beams (1064 nm wavelength) on water surfaces are characterized by strong absorption or specular reflection resulting in a dominance of low signal amplitude values and a high number of laser shot dropouts (i.e. non-recorded laser echoes). The occurrence of dropouts is driven by (i) the incidence angle, (ii) the surface reflectance and (iii) the roughness of the water body. The input data of the presented delineation method are the modeled dropouts and the point cloud attributes of geometry and signal amplitude. A terrestrial orthophoto is used to explore the point cloud in order to find proper information about the geometry and amplitude attributes that are characteristic for water surfaces. The delineation method is divided into five major steps. (a) We compute calibrated amplitude values by reducing the atmospheric, topographic influences and the scan geometry for each laser echo. (b) Then, the dropouts are modeled by using the information from the time stamps, the pulse repetition frequency, the inertial measurement unit and the GPS information of the laser shots and the airplane. The next step is to calculate the standard deviation of the heights for all reflections and all modeled dropouts (c) in a specific radius around the points. (d) We compute the amplitude ratio

Categorizing Health Websites: E-Knowledge, E-Business and E-Professional

ERIC Educational Resources Information Center

Usher, Wayne; Skinner, James

2011-01-01

This article presents three types of health website categories (e-knowledge, e-business and e-professional) which are currently being used to disseminate health-related information, services and medical literature to the health consumer and professional. Moreover, criteria which have been used to establish a health website's category is…

Mapping canopy defoliation by herbivorous insects at the individual tree level using bi-temporal airborne imaging spectroscopy and LiDAR measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, Ran; Dennison, Philip E.; Zhao, Feng

Defoliation by herbivorous insects is a widespread forest disturbance driver, affecting global forest health and ecosystem dynamics. Additionally, compared with time- and labor-intensive field surveys, remote sensing provides the only realistic approach to mapping canopy defoliation by herbivorous insects over large spatial and temporal scales. However, the spectral and structural signatures of defoliation by insects at the individual tree level have not been well studied. Additionally, the predictive power of spectral and structural metrics for mapping canopy defoliation has seldom been compared. These critical knowledge gaps prevent us from consistently detecting and mapping canopy defoliation by herbivorous insects across multiplemore » scales. During the peak of a gypsy moth outbreak in Long Island, New York in summer 2016, we leveraged bi-temporal airborne imaging spectroscopy (IS, i.e., hyperspectral imaging) and LiDAR measurements at 1m spatial resolution to explore the spectral and structural signatures of canopy defoliation in a mixed oak-pine forest. We determined that red edge and near-infrared spectral regions within the IS data were most sensitive to crown-scale defoliation severity. LiDAR measurements including B70 (i.e., 70th bincentile height), intensity skewness, and kurtosis were effectively able to detect structural changes caused by herbivorous insects. In addition to canopy leaf loss, increased exposure of understory and non-photosynthetic materials contributed to the detected spectral and structural signatures. Comparing the ability of individual sensors to map canopy defoliation, the LiDAR-only Ordinary Least-Square (OLS) model performed better than the IS-only model (Adj. R-squared = 0.77, RMSE = 15.37% vs. Adj. R- squared = 0.63, RMSE = 19.11%). The IS+LiDAR model improved on performance of the individual sensors (Adj. R-squared = 0.81, RMSE = 14.46%). Our study improves our understanding of spectral and structural signatures of

Mapping canopy defoliation by herbivorous insects at the individual tree level using bi-temporal airborne imaging spectroscopy and LiDAR measurements

DOE PAGES

Meng, Ran; Dennison, Philip E.; Zhao, Feng; ...

2018-06-19

Defoliation by herbivorous insects is a widespread forest disturbance driver, affecting global forest health and ecosystem dynamics. Additionally, compared with time- and labor-intensive field surveys, remote sensing provides the only realistic approach to mapping canopy defoliation by herbivorous insects over large spatial and temporal scales. However, the spectral and structural signatures of defoliation by insects at the individual tree level have not been well studied. Additionally, the predictive power of spectral and structural metrics for mapping canopy defoliation has seldom been compared. These critical knowledge gaps prevent us from consistently detecting and mapping canopy defoliation by herbivorous insects across multiplemore » scales. During the peak of a gypsy moth outbreak in Long Island, New York in summer 2016, we leveraged bi-temporal airborne imaging spectroscopy (IS, i.e., hyperspectral imaging) and LiDAR measurements at 1m spatial resolution to explore the spectral and structural signatures of canopy defoliation in a mixed oak-pine forest. We determined that red edge and near-infrared spectral regions within the IS data were most sensitive to crown-scale defoliation severity. LiDAR measurements including B70 (i.e., 70th bincentile height), intensity skewness, and kurtosis were effectively able to detect structural changes caused by herbivorous insects. In addition to canopy leaf loss, increased exposure of understory and non-photosynthetic materials contributed to the detected spectral and structural signatures. Comparing the ability of individual sensors to map canopy defoliation, the LiDAR-only Ordinary Least-Square (OLS) model performed better than the IS-only model (Adj. R-squared = 0.77, RMSE = 15.37% vs. Adj. R- squared = 0.63, RMSE = 19.11%). The IS+LiDAR model improved on performance of the individual sensors (Adj. R-squared = 0.81, RMSE = 14.46%). Our study improves our understanding of spectral and structural signatures of

Strategies for minimizing sample size for use in airborne LiDAR-based forest inventory

USGS Publications Warehouse

Junttila, Virpi; Finley, Andrew O.; Bradford, John B.; Kauranne, Tuomo

2013-01-01

Recently airborne Light Detection And Ranging (LiDAR) has emerged as a highly accurate remote sensing modality to be used in operational scale forest inventories. Inventories conducted with the help of LiDAR are most often model-based, i.e. they use variables derived from LiDAR point clouds as the predictive variables that are to be calibrated using field plots. The measurement of the necessary field plots is a time-consuming and statistically sensitive process. Because of this, current practice often presumes hundreds of plots to be collected. But since these plots are only used to calibrate regression models, it should be possible to minimize the number of plots needed by carefully selecting the plots to be measured. In the current study, we compare several systematic and random methods for calibration plot selection, with the specific aim that they be used in LiDAR based regression models for forest parameters, especially above-ground biomass. The primary criteria compared are based on both spatial representativity as well as on their coverage of the variability of the forest features measured. In the former case, it is important also to take into account spatial auto-correlation between the plots. The results indicate that choosing the plots in a way that ensures ample coverage of both spatial and feature space variability improves the performance of the corresponding models, and that adequate coverage of the variability in the feature space is the most important condition that should be met by the set of plots collected.

Estimating forest structural characteristics using the airborne LiDAR scanning system and a near-real time profiling laser system

NASA Astrophysics Data System (ADS)

Zhao, Kaiguang

LiDAR (Light Detection and Ranging) directly measures canopy vertical structures, and provides an effective remote sensing solution to accurate and spatially-explicit mapping of forest characteristics, such as canopy height and Leaf Area Index. However, many factors, such as large data volume and high costs for data acquisition, precludes the operational and practical use of most currently available LiDARs for frequent and large-scale mapping. At the same time, a growing need is arising for real-time remote sensing platforms, e.g., to provide timely information for urgent applications. This study aims to develop an airborne profiling LiDAR system, featured with on-the-fly data processing, for near real- or real-time forest inventory. The development of such a system involves implementing the on-board data processing and analysis as well as building useful regression-based models to relate LiDAR measurements with forest biophysical parameters. This work established a paradigm for an on-the-fly airborne profiling LiDAR system to inventory regional forest resources in real- or near real-time. The system was developed based on an existing portable airborne laser system (PALS) that has been previously assembled at NASA by Dr. Ross Nelson. Key issues in automating PALS as an on-the-fly system were addressed, including the design of an archetype for the system workflow, the development of efficient and robust algorithms for automatic data processing and analysis, the development of effective regression models to predict forest biophysical parameters from LiDAR measurements, and the implementation of an integrated software package to incorporate all the above development. This work exploited the untouched potential of airborne laser profilers for real-time forest inventory, and therefore, documented an initial step toward developing airborne-laser-based, on-the-fly, real-time, forest inventory systems. Results from this work demonstrated the utility and effectiveness of

LiDAR utility for natural resource managers

Treesearch

Andrew Thomas Hudak; Jeffrey Scott Evans; Alistair Mattthew Stuart Smith

2009-01-01

Applications of LiDAR remote sensing are exploding, while moving from the research to the operational realm. Increasingly, natural resource managers are recognizing the tremendous utility of LiDAR-derived information to make improved decisions. This review provides a cross-section of studies, many recent, that demonstrate the relevance of LiDAR across a suite of...

Assessing the Transferability of Statistical Predictive Models for Leaf Area Index Between Two Airborne Discrete Return LiDAR Sensor Designs Within Multiple Intensely Managed Loblolly Pine Forest Locations in the South-Eastern USA

NASA Technical Reports Server (NTRS)

Sumnall, Matthew; Peduzzi, Alicia; Fox, Thomas R.; Wynne, Randolph H.; Thomas, Valerie A.; Cook, Bruce

2016-01-01

Leaf area is an important forest structural variable which serves as the primary means of mass and energy exchange within vegetated ecosystems. The objective of the current study was to determine if leaf area index (LAI) could be estimated accurately and consistently in five intensively managed pine plantation forests using two multiple-return airborne LiDAR datasets. Field measurements of LAI were made using the LiCOR LAI2000 and LAI2200 instruments within 116 plots were established of varying size and within a variety of stand conditions (i.e. stand age, nutrient regime and stem density) in North Carolina and Virginia in 2008 and 2013. A number of common LiDAR return height and intensity distribution metrics were calculated (e.g. average return height), in addition to ten indices, with two additional variants, utilized in the surrounding literature which have been used to estimate LAI and fractional cover, were calculated from return heights and intensity, for each plot extent. Each of the indices was assessed for correlation with each other, and was used as independent variables in linear regression analysis with field LAI as the dependent variable. All LiDAR derived metrics were also entered into a forward stepwise linear regression. The results from each of the indices varied from an R2 of 0.33 (S.E. 0.87) to 0.89 (S.E. 0.36). Those indices calculated using ratios of all returns produced the strongest correlations, such as the Above and Below Ratio Index (ABRI) and Laser Penetration Index 1 (LPI1). The regression model produced from a combination of three metrics did not improve correlations greatly (R2 0.90; S.E. 0.35). The results indicate that LAI can be predicted over a range of intensively managed pine plantation forest environments accurately when using different LiDAR sensor designs. Those indices which incorporated counts of specific return numbers (e.g. first returns) or return intensity correlated poorly with field measurements. There were

Search for the decay KL to pi0 e+ e- and study of the decay KL to e+ e- gamma gamma

NASA Astrophysics Data System (ADS)

Mikelsons, Peter L.

The particle decay KL-->p0e+e- is a probe of direct CP violation, a phenomenon previously only seen in KL-->pp decays. Understanding direct CP violation is an important part of understanding violation of CP symmetry in general. Experimentally, one of the obstacles to studying KL-->p0e+e- is the rare decay KL-->e+e- gg , which can mimic KL-->p0e+e- . A study of KL-->p0e+e- and KL-->e+e- gg was made as part of the KTeV E799 experiment. K-->p0p0Dalitz decays were used for normalization, and a KL flux of (2.65 +/- 0.18) × 1011 decays was measured. We observed 1578 KL-->e+e- gg candidate events, of which 1516.5 +/- 1.8 remain after background subtraction. These events allow measurement of the Bergström, Massó, and Singer KLgg vertex form- factor parameter, aK*=+0.015+/- 0.12stat.+/-0.03sys. , in mild disagreement with the previously fit value of -0.28 +/- 0.08. This form-factor implies a corresponding branching ratio of G(KL-->e+e- g g,E*g>5 MeV)/G(KL-->all ) = (5.82+/-0.15stat.+/-0.31 sys.+/-0.19BR)× 10-7 , in agreement with the QED prediction. The search for KL-->p0e+e- found two candidate events. However, 1.06 +/- 0.41 events were expected from background processes. Therefore, we do not claim observation of KL-->p0e+e- . Instead, with a single-event sensitivity of 1.00 × 10 -10, we set an upper limit on the KL-->p0e+e- branching ratio of 4.86 × 10-10 at the 90% confidence level.

UAV-LiDAR accuracy and comparison to Structure from Motion photogrammetry

NASA Astrophysics Data System (ADS)

Kucharczyk, M.; Hugenholtz, C.; Zou, X.; Nesbit, P. R.; Barchyn, T.

2016-12-01

We compare the spatial accuracy of a UAV-LiDAR system with Structure from Motion (SfM) photogrammetry. UAV-based LiDAR remote sensing potentially offers advantages over SfM photogrammetry in vegetated terrain, particularly with respect to canopy penetration and related measurements of ground surface elevation and vegetation height; however, little quantitative evidence has been presented to date. To address this, we performed a case study at a field site in Alberta, Canada with six different land cover types: short grass, tall grass, short shrubs, tall shrubs, deciduous trees, and coniferous trees. Both UAV datasets were acquired on the same day. The SfM dataset was derived from images acquired by a senseFly eBee fixed-wing UAV equipped with a 16.1 megapixel RGB camera. The UAV-LiDAR system is a proprietary design that consists of a single-rotor helicopter (2-m rotor diameter) equipped with a Riegl VUX-1UAV laser scanner, KVH 1750 inertial measurement unit, and dual NovAtel GNSS receivers. We measured vegetation height from at least 30 samples in each land cover type and acquired check point measurements to determine horizontal and vertical accuracy. Vegetation height was measured manually for grasses and shrubs with a level staff, and with a total station for trees. Coordinates of horizontal and vertical check points were surveyed with real-time kinematic (RTK) GNSS. We followed standard methods for computing horizontal and vertical accuracies based on the 2015 guidelines from the American Society of Photogrammetry and Remote Sensing. Results will be presented at the AGU Fall Meeting.

Signalling to eIF4E in cancer

PubMed Central

Siddiqui, Nadeem; Sonenberg, Nahum

2015-01-01

Translational control plays a critical role in the regulation of gene expression in eukaryotes and affects many essential cellular processes, including proliferation, apoptosis and differentiation. Under most circumstances, translational control occurs at the initiation step at which the ribosome is recruited to the mRNA. The eukaryotic translation initiation factor 4E (eIF4E), as part of the eIF4F complex, interacts first with the mRNA and facilitates the recruitment of the 40S ribosomal subunit. The activity of eIF4E is regulated at many levels, most profoundly by two major signalling pathways: PI3K (phosphoinositide 3-kinase)/Akt (also known and Protein Kinase B, PKB)/mTOR (mechanistic/mammalian target of rapamycin) and Ras (rat sarcoma)/MAPK (mitogen-activated protein kinase)/Mnk (MAPK-interacting kinases). mTOR directly phosphorylates the 4E-BPs (eIF4E-binding proteins), which are inhibitors of eIF4E, to relieve translational suppression, whereas Mnk phosphorylates eIF4E to stimulate translation. Hyperactivation of these pathways occurs in the majority of cancers, which results in increased eIF4E activity. Thus, translational control via eIF4E acts as a convergence point for hyperactive signalling pathways to promote tumorigenesis. Consequently, recent works have aimed to target these pathways and ultimately the translational machinery for cancer therapy. PMID:26517881

Construction of novel Saccharomyces cerevisiae strains for bioethanol active dry yeast (ADY) production.

PubMed

Zheng, Daoqiong; Zhang, Ke; Gao, Kehui; Liu, Zewei; Zhang, Xing; Li, Ou; Sun, Jianguo; Zhang, Xiaoyang; Du, Fengguang; Sun, Peiyong; Qu, Aimin; Wu, Xuechang

2013-01-01

The application of active dry yeast (ADY) in bioethanol production simplifies operation processes and reduces the risk of bacterial contamination. In the present study, we constructed a novel ADY strain with improved stress tolerance and ethanol fermentation performances under stressful conditions. The industrial Saccharomyces cerevisiae strain ZTW1 showed excellent properties and thus subjected to a modified whole-genome shuffling (WGS) process to improve its ethanol titer, proliferation capability, and multiple stress tolerance for ADY production. The best-performing mutant, Z3-86, was obtained after three rounds of WGS, producing 4.4% more ethanol and retaining 2.15-fold higher viability than ZTW1 after drying. Proteomics and physiological analyses indicated that the altered expression patterns of genes involved in protein metabolism, plasma membrane composition, trehalose metabolism, and oxidative responses contribute to the trait improvement of Z3-86. This work not only successfully developed a novel S. cerevisiae mutant for application in commercial bioethanol production, but also enriched the current understanding of how WGS improves the complex traits of microbes.

Construction of Novel Saccharomyces cerevisiae Strains for Bioethanol Active Dry Yeast (ADY) Production

PubMed Central

Gao, Kehui; Liu, Zewei; Zhang, Xing; Li, Ou; Sun, Jianguo; Zhang, Xiaoyang; Du, Fengguang; Sun, Peiyong; Qu, Aimin; Wu, Xuechang

2013-01-01

The application of active dry yeast (ADY) in bioethanol production simplifies operation processes and reduces the risk of bacterial contamination. In the present study, we constructed a novel ADY strain with improved stress tolerance and ethanol fermentation performances under stressful conditions. The industrial Saccharomyces cerevisiae strain ZTW1 showed excellent properties and thus subjected to a modified whole-genome shuffling (WGS) process to improve its ethanol titer, proliferation capability, and multiple stress tolerance for ADY production. The best-performing mutant, Z3-86, was obtained after three rounds of WGS, producing 4.4% more ethanol and retaining 2.15-fold higher viability than ZTW1 after drying. Proteomics and physiological analyses indicated that the altered expression patterns of genes involved in protein metabolism, plasma membrane composition, trehalose metabolism, and oxidative responses contribute to the trait improvement of Z3-86. This work not only successfully developed a novel S. cerevisiae mutant for application in commercial bioethanol production, but also enriched the current understanding of how WGS improves the complex traits of microbes. PMID:24376860

3D turbulence measurements using three intersecting Doppler LiDAR beams: validation against sonic anemometry

NASA Astrophysics Data System (ADS)

Carbajo Fuertes, Fernando; Valerio Iungo, Giacomo; Porté-Agel, Fernando

2013-04-01

Nowadays communities of researchers and industry in the wind engineering and meteorology sectors demand extensive and accurate measurements of atmospheric boundary layer turbulence for a better understanding of its role in a wide range of onshore and offshore applications: wind resource evaluation, wind turbine wakes, meteorology forecast, pollution and urban climate studies, etc. Atmospheric turbulence has been traditionally investigated through sonic anemometers installed on meteorological masts. However, the setup and maintenance of instrumented masts is generally very costly and the available location for the measurements is limited by the fixed position and height of the facility. In order to overcome the above-mentioned shortcomings, a measurement technique is proposed, based on the reconstruction of the three-dimensional velocity vector from simultaneous measurements of three intersecting Doppler wind LiDARs. This measuring technique presents the main advantage of being able to measure the wind velocity at any point in space inside a very large volume, which can be set and optimized for each test. Furthermore, it is very flexible regarding its transportation, installation and operation in any type of terrain. On the other hand, LiDAR measurements are strongly affected by the aerosol concentration in the air, precipitation, and the spatial and temporal resolution is poorer than that of a sonic anemometer. All this makes the comparison between these two kinds of measurements a complex task. The accuracy of the technique has been assessed by this study against sonic anemometer measurements carried out at different heights on the KNMI's meteorological mast at Cabauw's experimental site for atmospheric research (CESAR) in the Netherlands. An early uncertainty analysis shows that one of the most important parameters to be taken into account is the relative angles between the intersecting laser beams, i.e., the position of each LiDAR on the terrain and their

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response

PubMed Central

Sukarieh, R.; Sonenberg, N.; Pelletier, J.

2009-01-01

Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E. PMID:19244480

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

PubMed

Sukarieh, R; Sonenberg, N; Pelletier, J

2009-05-01

Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.

Infrastructure Investment Protection with LiDAR

DOT National Transportation Integrated Search

2012-10-15

The primary goal of this research effort was to explore the wide variety of uses of LiDAR technology and to evaluate their : applicability to NCDOT practices. NCDOT can use this information about LiDAR in determining how and when the : technology can...

LiDAR for Air Quality Measurements

DOT National Transportation Integrated Search

2017-02-02

The overall goal of this research is to investigate a unique light detection and ranging (LiDAR) technology for ambient air quality measurement of particulate matter. The ODU team has recently received a state-of-the-art elastic LiDAR from NASA Langl...

Automatic construction of aerial corridor for navigation of unmanned aircraft systems in class G airspace using LiDAR

NASA Astrophysics Data System (ADS)

Feng, Dengchao; Yuan, Xiaohui

2016-05-01

According to the airspace classification by the Federal Aviation Agency, Class G airspace is the airspace at 1,200 feet or less to the ground, which is beneath class E airspace and between classes B-D cylinders around towered airstrips. However, the lack of flight supervision mechanism in this airspace, unmanned aerial system (UAS) missions pose many safety issues. Collision avoidance and route planning for UASs in class G airspace is critical for broad deployment of UASs in commercial and security applications. Yet, unlike road network, there is no stationary marker in airspace to identify corridors that are available and safe for UASs to navigate. In this paper, we present an automatic LiDAR-based airspace corridor construction method for navigation in class G airspace and a method for route planning to minimize collision and intrusion. Our idea is to combine LiDAR to automatically identify ground objects that pose navigation restrictions such as airports and high-rises. Digital terrain model (DTM) is derived from LiDAR point cloud to provide an altitude-based class G airspace description. Following the FAA Aeronautical Information Manual, the ground objects that define the restricted airspaces are used together with digital surface model derived from LiDAR data to construct the aerial corridor for navigation of UASs. Preliminary results demonstrate competitive performance and the construction of aerial corridor can be automated with much great efficiency.

LiDAR - An emerging tool for geological applications

USGS Publications Warehouse

Stoker, Jason M.

2012-01-01

Over the past five to ten years the use and applicability of light detection and ranging (LiDAR) technology has increased dramatically. As a result, more and more LiDAR data now are being collected across the country for a wide range of applications, and LiDAR currently is the technology of choice for high resolution terrain model creation, 3-D city and infrastructure modeling, forestry, and a wide range of scientific applications. LiDAR is a key technology for geological applications both within and outside the U.S. Geological Survey, and efforts are underway to try to collect high resolution LiDAR data for the entire United States (https://pubs.usgs.gov/fs/2012/3089/pdf/fs2012-3089.pdf).

Strata-based forest fuel classification for wild fire hazard assessment using terrestrial LiDAR

NASA Astrophysics Data System (ADS)

Chen, Yang; Zhu, Xuan; Yebra, Marta; Harris, Sarah; Tapper, Nigel

2016-10-01

Fuel structural characteristics affect fire behavior including fire intensity, spread rate, flame structure, and duration, therefore, quantifying forest fuel structure has significance in understanding fire behavior as well as providing information for fire management activities (e.g., planned burns, suppression, fuel hazard assessment, and fuel treatment). This paper presents a method of forest fuel strata classification with an integration between terrestrial light detection and ranging (LiDAR) data and geographic information system for automatically assessing forest fuel structural characteristics (e.g., fuel horizontal continuity and vertical arrangement). The accuracy of fuel description derived from terrestrial LiDAR scanning (TLS) data was assessed by field measured surface fuel depth and fuel percentage covers at distinct vertical layers. The comparison of TLS-derived depth and percentage cover at surface fuel layer with the field measurements produced root mean square error values of 1.1 cm and 5.4%, respectively. TLS-derived percentage cover explained 92% of the variation in percentage cover at all fuel layers of the entire dataset. The outcome indicated TLS-derived fuel characteristics are strongly consistent with field measured values. TLS can be used to efficiently and consistently classify forest vertical layers to provide more precise information for forest fuel hazard assessment and surface fuel load estimation in order to assist forest fuels management and fire-related operational activities. It can also be beneficial for mapping forest habitat, wildlife conservation, and ecosystem management.

Phylogenetic analysis of eIF4E-family members

PubMed Central

Joshi, Bhavesh; Lee, Kibwe; Maeder, Dennis L; Jagus, Rosemary

2005-01-01

Background Translation initiation in eukaryotes involves the recruitment of mRNA to the ribosome which is controlled by the translation factor eIF4E. eIF4E binds to the 5'-m7Gppp cap-structure of mRNA. Three dimensional structures of eIF4Es bound to cap-analogues resemble 'cupped-hands' in which the cap-structure is sandwiched between two conserved Trp residues (Trp-56 and Trp-102 of H. sapiens eIF4E). A third conserved Trp residue (Trp-166 of H. sapiens eIF4E) recognizes the 7-methyl moiety of the cap-structure. Assessment of GenBank NR and dbEST databases reveals that many organisms encode a number of proteins with homology to eIF4E. Little is understood about the relationships of these structurally related proteins to each other. Results By combining sequence data deposited in the Genbank databases, we have identified sequences encoding 411 eIF4E-family members from 230 species. These sequences have been deposited into an internet-accessible database designed for sequence comparisons of eIF4E-family members. Most members can be grouped into one of three classes. Class I members carry Trp residues equivalent to Trp-43 and Trp-56 of H. sapiens eIF4E and appear to be present in all eukaryotes. Class II members, possess Trp→Tyr/Phe/Leu and Trp→Tyr/Phe substitutions relative to Trp-43 and Trp-56 of H. sapiens eIF4E, and can be identified in Metazoa, Viridiplantae, and Fungi. Class III members possess a Trp residue equivalent to Trp-43 of H. sapiens eIF4E but carry a Trp→Cys/Tyr substitution relative to Trp-56 of H. sapiens eIF4E, and can be identified in Coelomata and Cnidaria. Some eIF4E-family members from Protista show extension or compaction relative to prototypical eIF4E-family members. Conclusion The expansion of sequenced cDNAs and genomic DNAs from all eukaryotic kingdoms has revealed a variety of proteins related in structure to eIF4E. Evolutionarily it seems that a single early eIF4E gene has undergone multiple gene duplications generating multiple

Quantifying biomass consumption and carbon release from the California Rim fire by integrating airborne LiDAR and Landsat OLI data.

PubMed

Garcia, Mariano; Saatchi, Sassan; Casas, Angeles; Koltunov, Alexander; Ustin, Susan; Ramirez, Carlos; Garcia-Gutierrez, Jorge; Balzter, Heiko

2017-02-01

Quantifying biomass consumption and carbon release is critical to understanding the role of fires in the carbon cycle and air quality. We present a methodology to estimate the biomass consumed and the carbon released by the California Rim fire by integrating postfire airborne LiDAR and multitemporal Landsat Operational Land Imager (OLI) imagery. First, a support vector regression (SVR) model was trained to estimate the aboveground biomass (AGB) from LiDAR-derived metrics over the unburned area. The selected model estimated AGB with an R 2 of 0.82 and RMSE of 59.98 Mg/ha. Second, LiDAR-based biomass estimates were extrapolated to the entire area before and after the fire, using Landsat OLI reflectance bands, Normalized Difference Infrared Index, and the elevation derived from LiDAR data. The extrapolation was performed using SVR models that resulted in R 2 of 0.73 and 0.79 and RMSE of 87.18 (Mg/ha) and 75.43 (Mg/ha) for the postfire and prefire images, respectively. After removing bias from the AGB extrapolations using a linear relationship between estimated and observed values, we estimated the biomass consumption from postfire LiDAR and prefire Landsat maps to be 6.58 ± 0.03 Tg (10 12  g), which translate into 12.06 ± 0.06 Tg CO2 e released to the atmosphere, equivalent to the annual emissions of 2.57 million cars.

Processing LiDAR Data to Predict Natural Hazards

NASA Technical Reports Server (NTRS)

Fairweather, Ian; Crabtree, Robert; Hager, Stacey

2008-01-01

ELF-Base and ELF-Hazards (wherein 'ELF' signifies 'Extract LiDAR Features' and 'LiDAR' signifies 'light detection and ranging') are developmental software modules for processing remote-sensing LiDAR data to identify past natural hazards (principally, landslides) and predict future ones. ELF-Base processes raw LiDAR data, including LiDAR intensity data that are often ignored in other software, to create digital terrain models (DTMs) and digital feature models (DFMs) with sub-meter accuracy. ELF-Hazards fuses raw LiDAR data, data from multispectral and hyperspectral optical images, and DTMs and DFMs generated by ELF-Base to generate hazard risk maps. Advanced algorithms in these software modules include line-enhancement and edge-detection algorithms, surface-characterization algorithms, and algorithms that implement innovative data-fusion techniques. The line-extraction and edge-detection algorithms enable users to locate such features as faults and landslide headwall scarps. Also implemented in this software are improved methodologies for identification and mapping of past landslide events by use of (1) accurate, ELF-derived surface characterizations and (2) three LiDAR/optical-data-fusion techniques: post-classification data fusion, maximum-likelihood estimation modeling, and hierarchical within-class discrimination. This software is expected to enable faster, more accurate forecasting of natural hazards than has previously been possible.

Observation of D+→ηe+νe

NASA Astrophysics Data System (ADS)

Mitchell, R. E.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.; Gao, K. Y.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Ecklund, K. M.; Severini, H.; Love, W.; Savinov, V.; Aquines, O.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Hu, D.; Moziak, B.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.; Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Naik, P.; Briere, R. A.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Mohapatra, D.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Selen, M.; White, E. J.; Wiss, J.

2009-02-01

Using a 281pb-1 data sample collected at the ψ(3770) resonance with the CLEO-c detector at the Cornell Electron Storage Ring, we report the first observation of D+→ηe+νe. We also set upper limits for D+→η'e+νe and D+→ϕe+νe that are about 2 orders of magnitude more restrictive than those obtained by previous experiments.

Research on the E-Textbook and E-Schoolbag in China: Constructing an Ecosystem of E-Textbook and E-Schoolbag

ERIC Educational Resources Information Center

Wu, Yonghe; Lin, Lin; Ma, Xiaoling; Zhu, Zhiting

2013-01-01

The e-Textbook and e-Schoolbag initiatives have received wide attention and have been seen as the trend towards future education. This paper describes the framework of e-Textbook and e-Schoolbag including its conceptual model and system model. It further discusses the five interconnected categories that form the main parts of this Ecosystem…

E-learning in Saudi Arabia: 'To E or not to E, that is the question'.

PubMed

Al-Shehri, Ali M

2010-09-01

The Kingdom of Saudi Arabia (KSA) has witnessed unprecedented growth in higher education and E-learning in recent times. In the last five years, one university and five colleges have been commissioned every month; 800 scholarships have been awarded every month for overseas study; a national center for E-learning has been established; and E-units or departments have been set-up in almost every university. E-learning has become important for discussion to quote Shakespeare 'To E or not to E that is the question.' To examine current and future developments and challenges of E-learning in KSA. A qualitative approach was used to explore views of 30 senior academicians involved in E-learning during their attendance at a two-week course on the subject. All participants considered themselves as decision makers on E-learning in their units or departments. They felt that E-learning had come to stay, but acknowledged challenges in respect of resources, organization, management, and information technology. The fast development of E-learning poses many challenges. Clear vision and strategic planning with prospective E-learners in mind are essential to make E-learning programs cost effective.

[Genetic analysis of the putative remains of general Władysław Sikorski].

PubMed

Kupiec, Tomasz; Branicki, Wojciech

2009-01-01

The paper presents results of genetic identification studies carried out in material collected during exhumation of the putative body of general Władysław Sikorski, buried in a sarcophagus in Saint Leonard's crypt in the Wawel Cathedral. The analysis of STR-type autosomal markers, Y-STR markers and sequences of HVI and HVII regions of mitochondrial DNA carried out in samples collected for genetic analysis--fragments of the thigh bone and a tooth--yielded a full set of results. The same mtDNA profile was also determined in hair revealed on the underpants and shirt secured from the studied body. The mitochondrial DNA profile determined in the bone material and also in the hair matched the profile characteristic for a female relative through the maternal line of general Władysław Sikorski. The obtained evidence supports the hypothesis that the studied body is that of general Sikorski. An additional analysis of position SNP rs12913832 located on the HERC2 gene revealed the presence of genotype C/C, which suggests that general Władysław Sikorski had light (most probably blue) eyes.

Shipborne LiDAR system for coastal change monitoring

NASA Astrophysics Data System (ADS)

Kim, chang hwan; Park, chang hong; Kim, hyun wook; hyuck Kim, won; Lee, myoung hoon; Park, hyeon yeong

2016-04-01

Coastal areas, used as human utilization areas like leisure space, medical care, ports and power plants, etc., are regions that are continuously changing and interconnected with oceans and land and the sea level has risen by about 8cm (1.9mm / yr) due to global warming from 1964 year to 2006 year in Korea. Coastal erosion due to sea-level rise has caused the problem of marine ecosystems and loss of tourism resources, etc. Regular monitoring of coastal erosion is essential at key locations with such volatility. But the survey method of land mobile LiDAR (light detection and ranging) system has much time consuming and many restrictions. For effective monitoring beach erosion, KIOST (Korea Institute of Ocean Science & Technology) has constructed a shipborne mobile LiDAR system. The shipborne mobile LiDAR system comprised a land mobile LiDAR (RIEGL LMS-420i), an INS (inertial navigation system, MAGUS Inertial+), a RTKGPS (LEICA GS15 GS25), and a fixed platform. The shipborne mobile LiDAR system is much more effective than a land mobile LiDAR system in the measuring of fore shore areas without shadow zone. Because the vessel with the shipborne mobile LiDAR system is continuously moved along the shoreline, it is possible to efficiently survey a large area in a relatively short time. Effective monitoring of the changes using the constructed shipborne mobile LiDAR system for seriously eroded coastal areas will be able to contribute to coastal erosion management and response.

Case Studies in e-RPL and e-PR

ERIC Educational Resources Information Center

Cameron, Roslyn; Miller, Allison

2014-01-01

The use of ePortfolios for recognition of prior learning (e-RPL) and for professional recognition (e-PR) is slowly gaining in popularity in the VET sector however their use is sporadic across educational sectors, disciplines, educational institutions and professions. Added to this is an array of purposes and types of e-RPL and e-PR models and…

A 3D convolutional neural network approach to land cover classification using LiDAR and multi-temporal Landsat imagery

NASA Astrophysics Data System (ADS)

Xu, Z.; Guan, K.; Peng, B.; Casler, N. P.; Wang, S. W.

2017-12-01

Landscape has complex three-dimensional features. These 3D features are difficult to extract using conventional methods. Small-footprint LiDAR provides an ideal way for capturing these features. Existing approaches, however, have been relegated to raster or metric-based (two-dimensional) feature extraction from the upper or bottom layer, and thus are not suitable for resolving morphological and intensity features that could be important to fine-scale land cover mapping. Therefore, this research combines airborne LiDAR and multi-temporal Landsat imagery to classify land cover types of Williamson County, Illinois that has diverse and mixed landscape features. Specifically, we applied a 3D convolutional neural network (CNN) method to extract features from LiDAR point clouds by (1) creating occupancy grid, intensity grid at 1-meter resolution, and then (2) normalizing and incorporating data into a 3D CNN feature extractor for many epochs of learning. The learned features (e.g., morphological features, intensity features, etc) were combined with multi-temporal spectral data to enhance the performance of land cover classification based on a Support Vector Machine classifier. We used photo interpretation for training and testing data generation. The classification results show that our approach outperforms traditional methods using LiDAR derived feature maps, and promises to serve as an effective methodology for creating high-quality land cover maps through fusion of complementary types of remote sensing data.

Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras

PubMed Central

Bianchini, Julie M.; Kitt, Khameeka N.; Gloerich, Martijn; Pokutta, Sabine; Weis, William I.

2015-01-01

As part of the E-cadherin–β-catenin–αE-catenin complex (CCC), mammalian αE-catenin binds F-actin weakly in the absence of force, whereas cytosolic αE-catenin forms a homodimer that interacts more strongly with F-actin. It has been concluded that cytosolic αE-catenin homodimer is not important for intercellular adhesion because E-cadherin/αE-catenin chimeras thought to mimic the CCC are sufficient to induce cell–cell adhesion. We show that, unlike αE-catenin in the CCC, these chimeras homodimerize, bind F-actin strongly, and inhibit the Arp2/3 complex, all of which are properties of the αE-catenin homodimer. To more accurately mimic the junctional CCC, we designed a constitutively monomeric chimera, and show that E-cadherin–dependent cell adhesion is weaker in cells expressing this chimera compared with cells in which αE-catenin homodimers are present. Our results demonstrate that E-cadherin/αE-catenin chimeras used previously do not mimic αE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer αE-catenin are required for strong cell–cell adhesion. PMID:26416960

One-step leapfrog ADI-FDTD method for simulating electromagnetic wave propagation in general dispersive media.

PubMed

Wang, Xiang-Hua; Yin, Wen-Yan; Chen, Zhi Zhang David

2013-09-09

The one-step leapfrog alternating-direction-implicit finite-difference time-domain (ADI-FDTD) method is reformulated for simulating general electrically dispersive media. It models material dispersive properties with equivalent polarization currents. These currents are then solved with the auxiliary differential equation (ADE) and then incorporated into the one-step leapfrog ADI-FDTD method. The final equations are presented in the form similar to that of the conventional FDTD method but with second-order perturbation. The adapted method is then applied to characterize (a) electromagnetic wave propagation in a rectangular waveguide loaded with a magnetized plasma slab, (b) transmission coefficient of a plane wave normally incident on a monolayer graphene sheet biased by a magnetostatic field, and (c) surface plasmon polaritons (SPPs) propagation along a monolayer graphene sheet biased by an electrostatic field. The numerical results verify the stability, accuracy and computational efficiency of the proposed one-step leapfrog ADI-FDTD algorithm in comparison with analytical results and the results obtained with the other methods.

Mapping of past stand-level forest disturbances and estimation of time since disturbance using simulated spaceborne LiDAR data

NASA Astrophysics Data System (ADS)

Sanchez Lopez, N.; Hudak, A. T.; Boschetti, L.

2017-12-01

Explicit information on the location, the size or the time since disturbance (TSD) at the forest stand level complements field inventories, improves the monitoring of forest attributes and the estimation of biomass and carbon stocks. Even-aged stands display homogenous structural parameters that have often been used as a proxy of stand age. Consequently, performing object-oriented analysis on Light Detection and Ranging (LiDAR) data has potential to detect historical stand-replacing disturbances. Recent research has shown good results in the delineation of forest stands as well as in the prediction of disturbance occurrence and TSD using airborne LiDAR data. Nevertheless, the use of airborne LiDAR for systematic monitoring of forest stands is limited by the sporadic availability of data and its high cost compared to satellite instruments. NASA's forthcoming Global Ecosystem Dynamics Investigations (GEDI) mission will provide systematically data on the vertical structure of the vegetation, but its use presents some challenges compared to the common discrete-return airborne LiDAR. GEDI will be a waveform instrument, hence the summary metrics will be different to those obtained with airborne LiDAR, and the sampling configuration could limit the utility of the data, especially on heterogeneous landscapes. The potential use of GEDI data for forest characterization at the stand level would therefore depend on the predictive power of the GEDI footprint metrics, and on the density of point samples relative to forest stand size (i.e. the number of observation/footprints per stand).In this study, we assess the performance of simulated GEDI-derived metrics for stand characterization and estimation of TSD, and the point density needed to adequately identify forest stands, which translates - due to the fixed sampling configuration - into the minimum temporal interval needed to collect a sufficient number of points. The study area was located in the Clear Creek, Selway River

Immunoglobulin E (IgE) and IgE-containing cells in human gastrointestinal fluids and tissues.

PubMed Central

Brown, W R; Borthistle, B K; Chen, S T

1975-01-01

Human gastric, small intestinal, colonic and rectal mucosae were examined for IgE-containing cells by single- and double-antibody immunofluorescence techniques, and IgE in intesinal fluids was measured by a double-antibody radioimmunoassay. IgE-containing cells were identified in all tissue specimens and comprised about 2% of all immunoglobulin-containing cells. Although less numerous than cells containing IgA, IgM or IgG, they were remarkably numerous in relation to the concentration of IgE in serum (about 0-001% of total immunoglobulin). IgE immunocytes were significantly more numerous in stomach and proximal small bowel than in colon and rectum, and were very numerous at bases of gastric and duodenal peptic ulcers. Measurable IgE was found in seventy-eight of eighty-five (92%) intestinal fluids. Sucrose gradient ultracentrifugation analysis of four of the fluids revealed that the immunologically reactive IgE was largely in fractions corresponding to molecules of lower molecular weight than that of albumin, which suggests that IgE in gut contents is degraded by proteolytic enzymes. The presence of IgE-forming cells in gastrointestinal tissues, and IgE or a fragment of IgE in intestinal fluids, suggests that IgE antibodies are available for participation in local reaginic-type reactions in the gut. Images FIG. 1 PMID:813925

Tropical Airborne LiDAR for Landslide Assessment in Malaysia: a technical perspective

NASA Astrophysics Data System (ADS)

Abd Manap, Mohamad; Azhari Razak, Khamarrul; Mohamad, Zakaria; Ahmad, Azhari; Ahmad, Ferdaus; Mohamad Zin, Mazlan; A'zad Rosle, Qalam

2015-04-01

Malaysia has faced a substantial number of landslide events every year. Cameron Highlands, Pahang is one of the badly areas affected by slope failures characterized by extreme climate, rugged topographic and weathered geological structures in a tropical environment. A high frequency of landslide occurrence in the hilly areas is predominantly due to the geological materials, tropical monsoon seasons and uncontrolled agricultural activities. Therefore the Government of Malaysia through the Prime Minister Department has allocated a special budget to conduct national level hazard and risk mapping project through Minerals and Geoscience Department Malaysia, the Ministry of Natural Resources and Environment. The primary aim of this project is to provide slope hazard risk information for a better slope management in Malaysia. In addition this project will establish national infrastructure for geospatial information on the geological terrain and slope by emphasizing the disaster risk throughout the country. The areas of interest are located in the three different selected areas i.e. Cameron Highlands (275 square kilometers), Ipoh (200 square kilometers) and Cheras Kajang -- Batang kali (650 square kilometers). These areas are selected based on National Slope Master Plan (2009 -- 2023) that endorsed by Malaysia Government Cabinet. The national hazard and risk mapping project includes six parts of major tasks: (1) desk study and mobilization, (2) airborne LiDAR data acquisition and analysis, (3) field data acquisition and verification, (4) hazard and risk for natural terrain, (5) hazard and risk analysis for man-made slope and (6) Man-made slope mitigation/preventive measures. The project was authorized in September, 2014 and will be ended in March, 2016. In this paper, the main focus is to evaluate the suitability of integrated capability of airborne- and terrestrial LiDAR data acquisition and analysis, and also digital photography for regional landslide assessment. The

Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques.

PubMed

Zhang, Rong; He, Yi-feng; Chen, Mo; Chen, Chun-mei; Zhu, Qiu-jing; Lu, Huan; Wei, Zhen-hong; Li, Fang; Zhang, Xiao-xin; Xu, Cong-jian; Yu, Long

2014-10-02

Cervical lesions caused by integrated human papillomavirus (HPV) infection are highly dangerous because they can quickly develop into invasive cancers. However, clinicians are currently hampered by the lack of a quick, convenient and precise technique to detect integrated/mixed infections of various genotypes of HPVs in the cervix. This study aimed to develop a practical tool to determine the physical status of different HPVs and evaluate its clinical significance. The target population comprised 1162 women with an HPV infection history of > six months and an abnormal cervical cytological finding. The multiple E1-L1/E6E7 ratio analysis, a novel technique, was developed based on determining the ratios of E1/E6E7, E2/E6E7, E4E5/E6E7, L2/E6E7 and L1/E6E7 within the viral genome. Any imbalanced ratios indicate integration. Its diagnostic and predictive performances were compared with those of E2/E6E7 ratio analysis. The detection accuracy of both techniques was evaluated using the gold-standard technique "detection of integrated papillomavirus sequences" (DIPS). To realize a multigenotypic detection goal, a primer and probe library was established. The integration rate of a particular genotype of HPV was correlated with its tumorigenic potential and women with higher lesion grades often carried lower viral loads. The E1-L1/E6E7 ratio analysis achieved 92.7% sensitivity and 99.0% specificity in detecting HPV integration, while the E2/E6E7 ratio analysis showed a much lower sensitivity (75.6%) and a similar specificity (99.3%). Interference due to episomal copies was observed in both techniques, leading to false-negative results. However, some positive results of E1-L1/E6E7 ratio analysis were missed by DIPS due to its stochastic detection nature. The E1-L1/E6E7 ratio analysis is more efficient than E2/E6E7 ratio analysis and DIPS in predicting precancerous/cancerous lesions, in which both positive predictive values (36.7%-82.3%) and negative predictive values (75

Estimation of the dietary intake of 13 priority additives in France, Italy, the UK and Ireland as part of the FACET project.

PubMed

Vin, Karine; Connolly, Aileen; McCaffrey, Tracy; McKevitt, Aideen; O'Mahony, Cian; Prieto, Miguel; Tennant, David; Hearty, Aine; Volatier, Jean Luc

2013-01-01

The aim of this study was to assess the dietary exposure of 13 priority additives in four European countries (France, Italy, the UK and Ireland) using the Flavourings, Additives and Contact Materials Exposure Task (FACET) software. The studied additives were benzoates (E210-213), nitrites (E249-250) and sulphites (E220-228), butylated hydroxytoluene (E321), polysorbates (E432-436), sucroses esters and sucroglycerides (E473-474), polyglycerol esters of fatty acids (E475), stearoyl-lactylates (E481-482), sorbitan esters (E493-494 and E491-495), phosphates (E338-343/E450-452), aspartame (E951) and acesulfame (E950). A conservative approach (based on individual consumption data combined with maximum permitted levels (Tier 2)) was compared with more refined estimates (using a fitted distribution of concentrations based on data provided by the food industry (Tier 3)). These calculations demonstrated that the estimated intake is below the acceptable daily intake (ADI) for nine of the studied additives. However, there was a potential theoretical exceedance of the ADI observed for four additives at Tier 3 for high consumers (97.5th percentile) among children: E220-228 in the UK and Ireland, E432-436 and E481-482 in Ireland, Italy and the UK, and E493-494 in all countries. The mean intake of E493-494 could potentially exceed the ADI for one age group of children (aged 1-4 years) in the UK. For adults, high consumers only in all countries had a potential intake higher than the ADI for E493-494 at Tier 3 (an additive mainly found in bakery wares). All other additives examined had an intake below the ADI. Further refined exposure assessments may be warranted to provide a more in-depth investigation for those additives that exceeded the ADIs in this paper. This refinement may be undertaken by the introduction of additive occurrence data, which take into account the actual presence of these additives in the different food groups.

Measurement of initial-state–final-state radiation interference in the processes e + e – → μ + μ – γ and e + e – → π + π – γ [Measurement of ISR-FSR interference in the processes e + e – → μ + μ – γ and e + e – → π + π – γ

DOE PAGES

Lees, J. P.; Poireau, V.; Tisserand, V.; ...

2015-10-28

Charge asymmetry in the processes e +e – → μ +μ –γ and e +e – → π +π –γ is measured using 232 fb –1 of data collected with the BABAR detector at e +e – center-of-mass energies near 10.58 GeV. An observable is introduced and shown to be very robust against detector asymmetries while keeping a large sensitivity to the physical charge asymmetry that results from the interference between initial- and final-state radiation (FSR). The asymmetry is determined as a function of the invariant mass of the final-state tracks from production threshold to a few GeV/c 2. Itmore » is compared to the expectation from QED for e +e – → μ +μ –γ, and from theoretical models for e +e – → π +π –γ. A clear interference pattern is observed in e +e – → π +π –γ, particularly in the vicinity of the f 2(1270) resonance. As a result, the inferred rate of lowest-order FSR production is consistent with the QED expectation for e +e – → μ +μ –γ, and is negligibly small for e +e – → π +π –γ.« less

Measurement of initial-state–final-state radiation interference in the processes e + e – → μ + μ – γ and e + e – → π + π – γ [Measurement of ISR-FSR interference in the processes e + e – → μ + μ – γ and e + e – → π + π – γ

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lees, J. P.; Poireau, V.; Tisserand, V.

Charge asymmetry in the processes e +e – → μ +μ –γ and e +e – → π +π –γ is measured using 232 fb –1 of data collected with the BABAR detector at e +e – center-of-mass energies near 10.58 GeV. An observable is introduced and shown to be very robust against detector asymmetries while keeping a large sensitivity to the physical charge asymmetry that results from the interference between initial- and final-state radiation (FSR). The asymmetry is determined as a function of the invariant mass of the final-state tracks from production threshold to a few GeV/c 2. Itmore » is compared to the expectation from QED for e +e – → μ +μ –γ, and from theoretical models for e +e – → π +π –γ. A clear interference pattern is observed in e +e – → π +π –γ, particularly in the vicinity of the f 2(1270) resonance. As a result, the inferred rate of lowest-order FSR production is consistent with the QED expectation for e +e – → μ +μ –γ, and is negligibly small for e +e – → π +π –γ.« less

Canopy wake measurements using multiple scanning wind LiDARs

NASA Astrophysics Data System (ADS)

Markfort, C. D.; Carbajo Fuertes, F.; Iungo, V.; Stefan, H. G.; Porte-Agel, F.

2014-12-01

Canopy wakes have been shown, in controlled wind tunnel experiments, to significantly affect the fluxes of momentum, heat and other scalars at the land and water surface over distances of ˜O(1 km), see Markfort et al. (EFM, 2013). However, there are currently no measurements of the velocity field downwind of a full-scale forest canopy. Point-based anemometer measurements of wake turbulence provide limited insight into the extent and details of the wake structure, whereas scanning Doppler wind LiDARs can provide information on how the wake evolves in space and varies over time. For the first time, we present measurements of the velocity field in the wake of a tall patch of forest canopy. The patch consists of two uniform rows of 40-meter tall deciduous, plane trees, which border either side of the Allée de Dorigny, near the EPFL campus. The canopy is approximately 250 m long, and it is approximately 40 m wide, along the direction of the wind. A challenge faced while making field measurements is that the wind rarely intersects a canopy normal to the edge. The resulting wake flow may be deflected relative to the mean inflow. Using multiple LiDARs, we measure the evolution of the wake due to an oblique wind blowing over the canopy. One LiDAR is positioned directly downwind of the canopy to measure the flow along the mean wind direction and the other is positioned near the canopy to evaluate the transversal component of the wind and how it varies with downwind distance from the canopy. Preliminary results show that the open trunk space near the base of the canopy results in a surface jet that can be detected just downwind of the canopy and farther downwind dissipates as it mixes with the wake flow above. A time-varying recirculation zone can be detected by the periodic reversal of the velocity near the surface, downwind of the canopy. The implications of canopy wakes for measurement and modeling of surface fluxes will be discussed.

Canopy wake measurements using multiple scanning wind LiDARs

NASA Astrophysics Data System (ADS)

Markfort, Corey D.; Carbajo Fuertes, Fernando; Valerio Iungo, Giacomo; Stefan, Heinz; Porté-Agel, Fernando

2014-05-01

Canopy wakes have been shown, in controlled wind tunnel experiments, to significantly affect the fluxes of momentum, heat and other scalars at the land and water surface over distances of ~O(1 km), see Markfort et al. (EFM, 2013). However, there are currently no measurements of the velocity field downwind of a full-scale forest canopy. Point-based anemometer measurements of wake turbulence provide limited insight into the extent and details of the wake structure, whereas scanning Doppler wind LiDARs can provide information on how the wake evolves in space and varies over time. For the first time, we present measurements of the velocity field in the wake of a tall patch of forest canopy. The patch consists of two uniform rows of 35-meter tall deciduous, plane trees, which border either side of the Allée de Dorigny, near the EPFL campus. The canopy is approximately 250 m long, and it is 35 m wide, along the direction of the wind. A challenge faced while making field measurements is that the wind rarely intersects a canopy normal to the edge. The resulting wake flow may be deflected relative to the mean inflow. Using multiple LiDARs, we measure the evolution of the wake due to an oblique wind blowing over the canopy. One LiDAR is positioned directly downwind of the canopy to measure the flow along the mean wind direction and the other is positioned near the canopy to evaluate the transversal component of the wind and how it varies with downwind distance from the canopy. Preliminary results show that the open trunk space near the base of the canopy results in a surface jet that can be detected just downwind of the canopy and farther downwind dissipates as it mixes with the wake flow above. A time-varying recirculation zone can be detected by the periodic reversal of the velocity vector near the surface, downwind of the canopy. The implications of canopy wakes for measurement and modeling of surface fluxes will be discussed.

E.C.E. Connection: A Newsletter for Early Childhood Education (E.C.E.), 1994-1998.

ERIC Educational Resources Information Center

E.C.E. Connection, 1998

1998-01-01

This document consists of the first 39 consecutive issues of the newsletter, "E.C.E. Connection," published monthly (except August) to offer information and support to early childhood practitioners. Articles from the 1994 issues include: "Some 'Affordable' Ideas To Brighten Your Classroom"; "A Notice Board: A Way To Keep…

Searching for new light gauge bosons at e+e- colliders

NASA Astrophysics Data System (ADS)

Alikhanov, I.; Paschos, E. A.

2018-06-01

Neutral gauge bosons beyond the Standard Model are becoming interesting as possible mediators to explain several experimental anomalies. They have small masses, below 1 GeV, and are referred to as dark photons, U , A' or Z' bosons. Electron-positron collision experiments at the B-factories provide the most straightforward way to probe bosons of this kind. In the present article, we study production of the bosons at e+e- colliders operating at GeV center-of-mass energies. We have studied two channels: e+e-→γ Z' and e+e-→e+e-Z'. Analytic expressions for the cross sections and various observables such as the energy spectra of the produced bosons and the final electrons from the Z' decays are derived. We have also studied the transverse momentum distribution of the bosons and the spatial distribution of the Z'→e+e- decay vertices. It is shown that these distributions provide distinct signatures of the bosons in e+e-→γ Z'. The reaction e+e-→e+e-Z' becomes important at small Z' scattering angles where its contribution to the overall yield may be larger by orders of magnitude compared to e+e-→γ Z'. The standard processes e+e-→γ γ and e+e-→e+e-γ that lead to the same signal are considered. We include numerical predictions for the production rates at the energy √{s }=10.5 GeV . The case with a light scalar boson is also discussed. The calculations are performed in detail and can be useful for additional studies.

Features of Point Clouds Synthesized from Multi-View ALOS/PRISM Data and Comparisons with LiDAR Data in Forested Areas

NASA Technical Reports Server (NTRS)

Ni, Wenjian; Ranson, Kenneth Jon; Zhang, Zhiyu; Sun, Guoqing

2014-01-01

LiDAR waveform data from airborne LiDAR scanners (ALS) e.g. the Land Vegetation and Ice Sensor (LVIS) havebeen successfully used for estimation of forest height and biomass at local scales and have become the preferredremote sensing dataset. However, regional and global applications are limited by the cost of the airborne LiDARdata acquisition and there are no available spaceborne LiDAR systems. Some researchers have demonstrated thepotential for mapping forest height using aerial or spaceborne stereo imagery with very high spatial resolutions.For stereo imageswith global coverage but coarse resolution newanalysis methods need to be used. Unlike mostresearch based on digital surface models, this study concentrated on analyzing the features of point cloud datagenerated from stereo imagery. The synthesizing of point cloud data from multi-view stereo imagery increasedthe point density of the data. The point cloud data over forested areas were analyzed and compared to small footprintLiDAR data and large-footprint LiDAR waveform data. The results showed that the synthesized point clouddata from ALOSPRISM triplets produce vertical distributions similar to LiDAR data and detected the verticalstructure of sparse and non-closed forests at 30mresolution. For dense forest canopies, the canopy could be capturedbut the ground surface could not be seen, so surface elevations from other sourceswould be needed to calculatethe height of the canopy. A canopy height map with 30 m pixels was produced by subtracting nationalelevation dataset (NED) fromthe averaged elevation of synthesized point clouds,which exhibited spatial featuresof roads, forest edges and patches. The linear regression showed that the canopy height map had a good correlationwith RH50 of LVIS data with a slope of 1.04 and R2 of 0.74 indicating that the canopy height derived fromPRISM triplets can be used to estimate forest biomass at 30 m resolution.

E-learning in Saudi Arabia: ‘To E or not to E, that is the question’

PubMed Central

Al-Shehri, Ali M.

2010-01-01

Background: The Kingdom of Saudi Arabia (KSA) has witnessed unprecedented growth in higher education and E-learning in recent times. In the last five years, one university and five colleges have been commissioned every month; 800 scholarships have been awarded every month for overseas study; a national center for E-learning has been established; and E-units or departments have been set-up in almost every university. E-learning has become important for discussion to quote Shakespeare ‘To E or not to E that is the question.’ Objectives: To examine current and future developments and challenges of E-learning in KSA. Materials and Methods: A qualitative approach was used to explore views of 30 senior academicians involved in E-learning during their attendance at a two-week course on the subject. Results: All participants considered themselves as decision makers on E-learning in their units or departments. They felt that E-learning had come to stay, but acknowledged challenges in respect of resources, organization, management, and information technology. Conclusion: The fast development of E-learning poses many challenges. Clear vision and strategic planning with prospective E-learners in mind are essential to make E-learning programs cost effective. PMID:21359026

Biofuels E0, E15, E85 Neurophysiology Data

EPA Pesticide Factsheets

Visual, auditory, somatosensory, and peripheral nerve evoked responses.This dataset is associated with the following publication:Herr , D., D. Freeborn , L. Degn , S.A. Martin, J. Ortenzio, L. Pantlin, C. Hamm , and W. Boyes. Neurophysiological Assessment of Auditory, Peripheral Nerve, Somatosensory, and Visual System Function After Developmental Exposure to Gasoline, E15 and E85 Vapors. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, USA, 54: 78-88, (2016).

Hidden-charm Pentaquark Production at e + e - Colliders

NASA Astrophysics Data System (ADS)

Li, Shi-Yuan; Liu, Yan-Rui; Liu, Yu-Nan; Si, Zong-Guo; Zhang, Xiao-Feng

2018-03-01

We study one possible production mechanism for the hidden-charm pentaquark via a color-octet c\\bar{c} pair fragmentation in e + e - collision. The pentaquark production at B factory energy is dominated by {e}+{e}-\\to c\\bar{c}g\\to {P}c+X, while at Z 0 pole energy, there are several partonic processes playing significant role. Our results show that it is possible to search for the direct pentaquark production signal at e + e - colliders, which is important to understand the properties of pentaquark. Supported by National Natural Science Foundation of China under Grant Nos. 11775130, 11775132, 11635009, 11325525 and the Natural Science Foundation of Shandong Province under Grant No. ZR2017MA002

Validation of the WristOx 3100 oximeter for the diagnosis of sleep apnea/hypopnea syndrome.

PubMed

Nigro, Carlos Alberto; Aimaretti, Silvia; Gonzalez, Sergio; Rhodius, Edgardo

2009-05-01

To evaluate the diagnostic accuracy of the Nonin WristOx 3100 and its software (nVision 5.0) in patients with suspicion of sleep apnea/hypopnea syndrome (SAHS). All participants (168) had the oximetry and polysomnography simultaneously. The two recordings were interpreted blindly. The software calculated: adjusted O(2) desaturation index [ADI]-mean number of O(2) desaturation per hour of total recording analyzed time of > or = 2%, 3%, 4%, 5%, and 6% (ADI2, 3, 4, 5, and 6) and AT90-accumulated time at SO(2) < 90%. The ADI2, 3, 4, 5, and 6 and the AT90 cutoff points that better discriminated between subjects with or without SAHS arose from the receiver operating characteristic curve analysis. The sensitivity (S), specificity (E), and positive and negative likelihood ratio (LR+, LR-) for the different thresholds for ADI were calculated. One hundred and fifty-four patients were included (119 men, mean age 51, median apnea/hypopnea index [AHI] 14, median body mass index [BMI] 28.3 kg/m(2)). The best cutoff points of ADI were: SAHS = AHI > or = 5: ADI2 > 19.3 (S 89%, E 94%, LR+ 15.5 LR- 0.11); SAHS =AHI > or = 10: ADI3 > 10.5 (S 88%, E 94%, LR+ 15 LR- 0.12); SAHS = AHI > or = 15: ADI3 > 13.4 (S 88%, E 90%, LR+ 8.9, LR- 0.14). AT90 had the lowest diagnosis accuracy. An ADI2 < or = 12.2 excluded SAHS (AHI > or = 5 and 10; S 100%, LR- 0) and ADI3 > 4.3 (AHI > or = 5 and 10) or 32 (AHI > or = 15) confirmed SAHS (E 100%). A negative oximetry defined as ADI2 < or = 12.2 excluded SAHS defined as AHI > or = 5 or 10 with a sensitivity and negative likelihood ratio of 100% and 0%, respectively. Furthermore, a positive oximetry defined as an ADI3 > 32 (SAHS = AHI > or = 15) had a specificity of 100% to confirm the pathology.

Achieving Accuracy Requirements for Forest Biomass Mapping: A Data Fusion Method for Estimating Forest Biomass and LiDAR Sampling Error with Spaceborne Data

NASA Technical Reports Server (NTRS)

Montesano, P. M.; Cook, B. D.; Sun, G.; Simard, M.; Zhang, Z.; Nelson, R. F.; Ranson, K. J.; Lutchke, S.; Blair, J. B.

2012-01-01

The synergistic use of active and passive remote sensing (i.e., data fusion) demonstrates the ability of spaceborne light detection and ranging (LiDAR), synthetic aperture radar (SAR) and multispectral imagery for achieving the accuracy requirements of a global forest biomass mapping mission. This data fusion approach also provides a means to extend 3D information from discrete spaceborne LiDAR measurements of forest structure across scales much larger than that of the LiDAR footprint. For estimating biomass, these measurements mix a number of errors including those associated with LiDAR footprint sampling over regional - global extents. A general framework for mapping above ground live forest biomass (AGB) with a data fusion approach is presented and verified using data from NASA field campaigns near Howland, ME, USA, to assess AGB and LiDAR sampling errors across a regionally representative landscape. We combined SAR and Landsat-derived optical (passive optical) image data to identify forest patches, and used image and simulated spaceborne LiDAR data to compute AGB and estimate LiDAR sampling error for forest patches and 100m, 250m, 500m, and 1km grid cells. Forest patches were delineated with Landsat-derived data and airborne SAR imagery, and simulated spaceborne LiDAR (SSL) data were derived from orbit and cloud cover simulations and airborne data from NASA's Laser Vegetation Imaging Sensor (L VIS). At both the patch and grid scales, we evaluated differences in AGB estimation and sampling error from the combined use of LiDAR with both SAR and passive optical and with either SAR or passive optical alone. This data fusion approach demonstrates that incorporating forest patches into the AGB mapping framework can provide sub-grid forest information for coarser grid-level AGB reporting, and that combining simulated spaceborne LiDAR with SAR and passive optical data are most useful for estimating AGB when measurements from LiDAR are limited because they minimized

Search for the rare decays J /ψ →D0e+e-+c .c . and ψ (3686 )→D0e+e-+c .c .

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dorjkhaidav, O.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, S.; Gu, Y. T.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Khan, T.; Kiese, P.; Kliemt, R.; Kloss, B.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuhlmann, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Lavezzi, L.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Morello, G.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, J. J.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B. T.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Wei, J. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Y. J.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. H.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhou, Y. X.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2017-12-01

Using the data samples of (1310.6 ±7.2 )×106 J /ψ events and (448.1 ±2.9 )×106 ψ (3686 ) events collected with the BESIII detector, we search for the rare decays J /ψ →D0e+e-+c .c . and ψ (3686 )→D0e+e-+c .c . No significant signals are observed and the corresponding upper limits on the branching fractions at the 90% confidence level are determined to be B (J /ψ →D0e+e-+c .c .)<8.5 ×10-8 and B (ψ (3686 )→D0e+e-+c .c .)<1.4 ×10-7 , respectively. Our limit on B (J /ψ →D0e+e-+c .c .) is more stringent by 2 orders of magnitude than the previous results, and B (ψ (3686 )→D0e+e-+c .c .) is measured for the first time.

Contrasting Patterns of Damage and Recovery in Logged Amazon Forests From Small Footprint LiDAR Data

NASA Technical Reports Server (NTRS)

Morton, D. C.; Keller, M.; Cook, B. D.; Hunter, Maria; Sales, Marcio; Spinelli, L.; Victoria, D.; Andersen, H.-E.; Saleska, S.

2012-01-01

Tropical forests ecosystems respond dynamically to climate variability and disturbances on time scales of minutes to millennia. To date, our knowledge of disturbance and recovery processes in tropical forests is derived almost exclusively from networks of forest inventory plots. These plots typically sample small areas (less than or equal to 1 ha) in conservation units that are protected from logging and fire. Amazon forests with frequent disturbances from human activity remain under-studied. Ongoing negotiations on REDD+ (Reducing Emissions from Deforestation and Forest Degradation plus enhancing forest carbon stocks) have placed additional emphasis on identifying degraded forests and quantifying changing carbon stocks in both degraded and intact tropical forests. We evaluated patterns of forest disturbance and recovery at four -1000 ha sites in the Brazilian Amazon using small footprint LiDAR data and coincident field measurements. Large area coverage with airborne LiDAR data in 2011-2012 included logged and unmanaged areas in Cotriguacu (Mato Grosso), Fiona do Jamari (Rondonia), and Floresta Estadual do Antimary (Acre), and unmanaged forest within Reserva Ducke (Amazonas). Logging infrastructure (skid trails, log decks, and roads) was identified using LiDAR returns from understory vegetation and validated based on field data. At each logged site, canopy gaps from logging activity and LiDAR metrics of canopy heights were used to quantify differences in forest structure between logged and unlogged areas. Contrasting patterns of harvesting operations and canopy damages at the three logged sites reflect different levels of pre-harvest planning (i.e., informal logging compared to state or national logging concessions), harvest intensity, and site conditions. Finally, we used multi-temporal LiDAR data from two sites, Reserva Ducke (2009, 2012) and Antimary (2010, 2011), to evaluate gap phase dynamics in unmanaged forest areas. The rates and patterns of canopy gap

Ex Vivo Oxidation in Tissue and Plasma Assays of Hydroxyoctadecadienoates: (Z,E/E,E)-Stereoisomer Ratios

PubMed Central

Liu, Wei; Yin, Huiyong; Akazawa, Yoko Ogawa; Yoshida, Yasukazu; Niki, Etsuo; Porter, Ned A.

2010-01-01

The primary products from peroxidation of linoleate in biological tissues and fluids are the hydroperoxy octadecadienoates and the products normally assayed, after reduction of the hydroperoxides, are the corresponding hydroxy octadecadienoates (HODEs). The HODEs are found in tissues and fluids as a mixture of Z,E and E,E stereoisomers. Two regioisomeric sets of Z,E and E,E stereoisomers are normally observed with substitution at the 9 and 13 position of the 18-carbon chain. The Z,E/E,E product ratio has proved to be a useful means for assessing the reducing capacity of the medium undergoing peroxidation. The HODE Z,E/E,E product ratios previously reported for tissues such as liver and brain vary from 0.5 to 2.0 and plasma ratios are somewhat higher, between 2.0 and 3.0. The reported literature protocols for HODE assay in tissues involve homogenization, reduction with sodium borohydride in the presence of BHT, and ester hydrolysis with KOH to give the free HODEs. This is followed by either reverse-phase HPLC of the free acid HODEs or by conversion to TMS derivatives and GC/MS. When sodium borohydride is replaced in the protocol by triphenylphosphine, a gentler reducing agent, HODE Z,E/E,E product ratios are much higher and lower total HODEs levels of are found. It is proposed that inclusion of sodium borohydride in the isolation procedures leads to ex vivo reactions that are avoided if triphenylphosphine is used as the reducing agent. Modified protocols for HODE analyses (Tissue and Plasma Methods #2) are described that should be used for assays of tissues and fluids. PMID:20423158

A microsatellite guided insight into the genetic status of adi, an isolated hunting-gathering tribe of northeast India.

PubMed

Krithika, S; Maji, Suvendu; Vasulu, T S

2008-07-02

Tibeto-Burman populations of India provide an insight into the peopling of India and aid in understanding their genetic relationship with populations of East, South and Southeast Asia. The study investigates the genetic status of one such Tibeto-Burman group, Adi of Arunachal Pradesh based on 15 autosomal microsatellite markers. Further the study examines, based on 9 common microsatellite loci, the genetic relationship of Adi with 16 other Tibeto-Burman speakers of India and 28 neighboring populations of East and Southeast Asia. Overall, the results support the recent formation of the Adi sub-tribes from a putative ancestral group and reveal that geographic contiguity is a major influencing factor of the genetic affinity among the Tibeto-Burman populations of India.

A Microsatellite Guided Insight into the Genetic Status of Adi, an Isolated Hunting-Gathering Tribe of Northeast India

PubMed Central

Krithika, S.; Maji, Suvendu; Vasulu, T. S.

2008-01-01

Tibeto-Burman populations of India provide an insight into the peopling of India and aid in understanding their genetic relationship with populations of East, South and Southeast Asia. The study investigates the genetic status of one such Tibeto-Burman group, Adi of Arunachal Pradesh based on 15 autosomal microsatellite markers. Further the study examines, based on 9 common microsatellite loci, the genetic relationship of Adi with 16 other Tibeto-Burman speakers of India and 28 neighboring populations of East and Southeast Asia. Overall, the results support the recent formation of the Adi sub-tribes from a putative ancestral group and reveal that geographic contiguity is a major influencing factor of the genetic affinity among the Tibeto-Burman populations of India. PMID:18596928

Discrimination between E. granulosus sensu stricto, E. multilocularis and E. shiquicus Using a Multiplex PCR Assay

PubMed Central

Li, Li; Yan, Hong-Bin; Blair, David; Lei, Meng-Tong; Cai, Jin-Zhong; Fan, Yan-Lei; Li, Jian-Qiu; Fu, Bao-Quan; Yang, Yu-Rong; McManus, Donald P.; Jia, Wan-Zhong

2015-01-01

Background Infections of Echinococcus granulosus sensu stricto (s.s), E. multilocularis and E. shiquicus are commonly found co-endemic on the Qinghai-Tibet plateau, China, and an efficient tool is needed to facilitate the detection of infected hosts and for species identification. Methodology/Principal Findings A single-tube multiplex PCR assay was established to differentiate the Echinococcus species responsible for infections in intermediate and definitive hosts. Primers specific for E. granulosus, E. multilocularis and E. shiquicus were designed based on sequences of the mitochondrial NADH dehydrogenase subunit 1 (nad1), NADH dehydrogenase subunit 5 (nad5) and cytochrome c oxidase subunit 1 (cox1) genes, respectively. This multiplex PCR accurately detected Echinococcus DNA without generating nonspecific reaction products. PCR products were of the expected sizes of 219 (nad1), 584 (nad5) and 471 (cox1) bp. Furthermore, the multiplex PCR enabled diagnosis of multiple infections using DNA of protoscoleces and copro-DNA extracted from fecal samples of canine hosts. Specificity of the multiplex PCR was 100% when evaluated using DNA isolated from other cestodes. Sensitivity thresholds were determined for DNA from protoscoleces and from worm eggs, and were calculated as 20 pg of DNA for E. granulosus and E. shiquicus, 10 pg of DNA for E. multilocularis, 2 eggs for E. granulosus, and 1 egg for E. multilocularis. Positive results with copro-DNA could be obtained at day 17 and day 26 after experimental infection of dogs with larval E. multilocularis and E. granulosus, respectively. Conclusions/Significance The multiplex PCR developed in this study is an efficient tool for discriminating E. granulosus, E. multilocularis and E. shiquicus from each other and from other taeniid cestodes. It can be used for the detection of canids infected with E. granulosus s.s. and E. multilocularis using feces collected from these definitive hosts. It can also be used for the identification

Study of the decays D + → η ( ' ) e + ν e

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2018-05-31

The charm semileptonic decays D + → ηe +v e and D + → η'e+v e are studied with a sample of e +e - collision data corresponding to an integrated luminosity of 2.93 fb -1 collected atmore » $$ \\sqrt{s}=3.773 $$ GeV with the BESIII detector. We measure the branching fractions for D+ → ηe+v e to be (10.74 ± 0.81 ± 0.51) x 10 -4, and for D+ → → η'e+v e to be (1.91 ± 0.51 ± 0.13) x 10 -4, where the uncertainties are statistical and systematic, respectively. In addition, we perform a measurement of the form factor in the decay D+ → ηe+v e. All the results are consistent with those obtained by the CLEO-c experiment.« less

Study of the decays D + → η ( ' ) e + ν e

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

The charm semileptonic decays D + → ηe +v e and D + → η'e+v e are studied with a sample of e +e - collision data corresponding to an integrated luminosity of 2.93 fb -1 collected atmore » $$ \\sqrt{s}=3.773 $$ GeV with the BESIII detector. We measure the branching fractions for D+ → ηe+v e to be (10.74 ± 0.81 ± 0.51) x 10 -4, and for D+ → → η'e+v e to be (1.91 ± 0.51 ± 0.13) x 10 -4, where the uncertainties are statistical and systematic, respectively. In addition, we perform a measurement of the form factor in the decay D+ → ηe+v e. All the results are consistent with those obtained by the CLEO-c experiment.« less

Integration of airborne LiDAR data and voxel-based ray tracing to determine high-resolution solar radiation dynamics at the forest floor: implications for improving stand-scale distributed snowmelt models

NASA Astrophysics Data System (ADS)

Musselman, K. N.; Molotch, N. P.; Margulis, S. A.

2012-12-01

Forest architecture dictates sub-canopy solar irradiance and the resulting patterns can vary seasonally and over short spatial distances. These radiation dynamics are thought to have significant implications on snowmelt processes, regional hydrology, and remote sensing signatures. The variability calls into question many assumptions inherent in traditional canopy models (e.g. Beer's Law) when applied at high resolution (i.e. 1 m). We present a method of estimating solar canopy transmissivity using airborne LiDAR data. The canopy structure is represented in 3-D voxel space (i.e. a cubic discretization of a 3-D domain analogous to a pixel representation of a 2-D space). The solar direct beam canopy transmissivity (DBT) is estimated with a ray-tracing algorithm and the diffuse component is estimated from LiDAR-derived effective LAI. Results from one year at five-minute temporal and 1 m spatial resolutions are presented from Sequoia National Park. Compared to estimates from 28 hemispherical photos, the ray-tracing model estimated daily mean DBT with a 10% average error, while the errors from a Beer's-type DBT estimate exceeded 20%. Compared to the ray-tracing estimates, the Beer's-type transmissivity method was unable to resolve complex spatial patterns resulting from canopy gaps, individual tree canopies and boles, and steep variable terrain. The snowmelt model SNOWPACK was applied at locations of ultrasonic snow depth sensors. Two scenarios were tested; 1) a nominal case where canopy model parameters were obtained from hemispherical photographs, and 2) an explicit scenario where the model was modified to accept LiDAR-derived time-variant DBT. The bulk canopy treatment was generally unable to simulate the sub-canopy snowmelt dynamics observed at the depth sensor locations. The explicit treatment reduced error in the snow disappearance date by one week and both positive and negative melt-season SWE biases were reduced. The results highlight the utility of LiDAR canopy

Novel Methods for Measuring LiDAR

NASA Astrophysics Data System (ADS)

Ayrey, E.; Hayes, D. J.; Fraver, S.; Weiskittel, A.; Cook, B.; Kershaw, J.

2017-12-01

The estimation of forest biometrics from airborne LiDAR data has become invaluable for quantifying forest carbon stocks, forest and wildlife ecology research, and sustainable forest management. The area-based approach is arguably the most common method for developing enhanced forest inventories from LiDAR. It involves taking a series of vertical height measurements of the point cloud, then using those measurements with field measured data to develop predictive models. Unfortunately, there is considerable variation in methodology for collecting point cloud data, which can vary in pulse density, seasonality, canopy penetrability, and instrument specifications. Today there exists a wealth of public LiDAR data, however the variation in acquisition parameters makes forest inventory prediction by traditional means unreliable across the different datasets. The goal of this project is to test a series of novel point cloud measurements developed along a conceptual spectrum of human interpretability, and then to use the best measurements to develop regional enhanced forest inventories on Northern New England's and Atlantic Canada's public LiDAR. Similarly to a field-based inventory, individual tree crowns are being segmented, and summary statistics are being used as covariates. Established competition and structural indices are being generated using each tree's relationship to one another, whilst existing allometric equations are being used to estimate diameter and biomass of each tree measured in the LiDAR. Novel metrics measuring light interception, clusteredness, and rugosity are also being measured as predictors. On the other end of the human interpretability spectrum, convolutional neural networks are being employed to directly measure both the canopy height model, and the point clouds by scanning each using two and three dimensional kernals trained to identify features useful for predicting biological attributes such as biomass. Predictive models will be trained and

Mapping and Monitoring Delmarva Fox Squirrel Habitat Using an Airborne LiDAR Profiler

NASA Technical Reports Server (NTRS)

Nelson, Ross; Ratnaswamy, Mary; Keller, Cherry

2004-01-01

Twenty five hundred thirty nine kilometers of airborne laser profiling and videography data were acquired over the state of Delaware during the summer of 2000. The laser ranging measurements and video from approximately one-half of that data set (1304 km) were analyzed to identify and locate forested sites that might potentially support populations of Delmarva fox squirrel (DFS, Sciurus niger cinereus). The DFS is an endangered species previously endemic to tall, dense, mature forests with open understories on the Eastern Shore of the Chesapeake Bay. The airborne LiDAR employed in this study can measure forest canopy height and canopy closure, but cannot measure or infer understory canopy conditions. Hence the LiDAR must be viewed as a tool to map potential, not actual, habitat. Fifty-three potentially suitable DFS sites were identified in the 1304 km of flight transect data. Each of the 53 sites met the following criteria according to the LiDAR and video record: (1 ) at least 120m of contiguous forest; (2) an average canopy height greater than 20m; (3) an average canopy closure of >80%; and (4) no roofs, impervious surface (e.g., asphalt, concrete), and/or open water anywhere along the 120m length of the laser segment. Thirty-two of the 53 sites were visited on the ground and measurements taken for a DFS habitat suitability model. Seventy eight percent of the sites (25 of 32) were judged by the model to be suited to supporting a DFS population. Twenty-eight of the 32 sites visited in the field were in forest cover types (hardwood, mixed wood, conifer, wetlands) according to a land cover GIS map. Of these, 23 (82%) were suited to support DFS. The remaining 4 sites were located in nonforest cover types - agricultural or residential areas. Two of the four, or 50% were suited to the DFS. All of the LiDAR flight data, 2539 km, were analyzed to

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, REMOVAL OF ARSENIC IN DRINKING WATER: ADI INTERNATIONAL INC. ADI PILOT TEST UNIT NO. 2002-09 WITH MEDIA G2®; PHASE II

EPA Science Inventory

Verification testing of the ADI International Inc. Unit No. 2002-09 with MEDIA G2® arsenic adsorption media filter system was conducted at the Hilltown Township Water and Sewer Authority (HTWSA) Well Station No. 1 in Sellersville, Pennsylvania from October 8, 2003 through May 28,...

The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials.

PubMed

Synakiewicz, Anna; Stachowicz-Stencel, Teresa; Adamkiewicz-Drozynska, Elzbieta

2014-11-01

The metabolic differences between normal, healthy cells and neoplastic cells have been exploited by anticancer therapies targeting metabolic pathways. Various studies of malignant processes have demonstrated disturbances in both arginine synthesis and metabolism that enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzyme arginine deiminase (ADI) as a potential antineoplastic therapy. This review summarizes the literature on the potential anti-cancer therapeutics arginine and ADI, an arginine-catabolizing enzyme. The authors searched the MEDLINE database PubMed using the key words: 'arginine, 'ADI', 'arginine in cancer' and 'ADI and cancer'. The authors evaluate prospective randomized studies on cancer patients between 2004 and 2013 as well as ongoing research found through the US National Institutes of Health trial database. The results of current studies are promising but do not give unequivocal answers and so it is impossible to recommend arginine or its enzyme ADI as a therapeutic. In the opinion of the authors, further identification of arginine-dependent malignant tumors and their metabolism should be investigated. Furthermore, the use of these chemicals, in combination with other chemotherapeutics drugs, should be investigated and indeed may improve the success of arginine-depleting enzymes such as pegylated ADI (ADI-PEG20).

Does Personalized Water and Hand Quality Information Affect Attitudes, Behavior, and Health in Dar es Salaam, Tanzania?

NASA Astrophysics Data System (ADS)

Davis, J.; Pickering, A.; Horak, H.; Boehm, A.

2008-12-01

Tanzania (TZ) has one of the highest rates of child mortality due to enteric disease in the world. NGOs and local agencies have introduced numerous technologies (e.g., chlorine tablets, borewells) to increase the quantity and quality of water in Dar es Salaam, the capital of Tanzania, in hopes of reducing morbidity and mortality of waterborne disease. The objective of the present study is to determine if providing personalized information about water quality and hand surface quality, as determined by concentrations of enterococci and E. coli, results in improved health and water quality in households. A cohort study was completed in June-September 2008 in 3 communities ranging from urban to per-urban in Dar es Salaam, Tanzania to achieve our objective. The study consisted of 4 cohorts that were visited 4 times over the 3 month study. One cohort received no information about water and hand quality until the end of the summer, while the other groups received either just information on hand surface quality, just information on water quality, and information on both hand surface and water quality after the first (baseline) household visit. We report concentrations of enterococci and E. coli in water sources (surface waters and bore wells), water stored in households, and environmental waters were children and adults swim and bathe. In addition, we report concentrations of enterococci and E. coli on hands of caregivers and children in households. Preliminary results of surveys on health and perceptions of water quality and illness from the households are provided. Ongoing work will integrate the microbiological and sociological data sets to determine if personalized information interventions resulted in changes in health, water quality in the household, or perceptions of water quality, quantity and relation to human health. Future work will analyze DNA samples from hands and water for human-specific Bacteroides bacteria which are only present in human feces. Our study

Experimental test of the mechanism of reaction for (e,e'p) coincidence experiment. [/sup 12/C(e,e'p): DWIA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernheim, M.; Bussiere, A.; Frullani, S.

1977-06-27

In order to test the validity of the distorted wave impulse approximation to describe (e,e'p) reactions and/or the suitability of the available optical potential parameters to calculate the distortion, the spectral function was measured for /sub 12/C(e,e'p)/sub 11/B in different kinematical configurations. Experimental results are shown together with the distributions computed with several values of the optical potential parameters. Data seem to indicate the necessity of using different parameters for p hole states and s hole states.

ePIANNO: ePIgenomics ANNOtation tool.

PubMed

Liu, Chia-Hsin; Ho, Bing-Ching; Chen, Chun-Ling; Chang, Ya-Hsuan; Hsu, Yi-Chiung; Li, Yu-Cheng; Yuan, Shin-Sheng; Huang, Yi-Huan; Chang, Chi-Sheng; Li, Ker-Chau; Chen, Hsuan-Yu

2016-01-01

Recently, with the development of next generation sequencing (NGS), the combination of chromatin immunoprecipitation (ChIP) and NGS, namely ChIP-seq, has become a powerful technique to capture potential genomic binding sites of regulatory factors, histone modifications and chromatin accessible regions. For most researchers, additional information including genomic variations on the TF binding site, allele frequency of variation between different populations, variation associated disease, and other neighbour TF binding sites are essential to generate a proper hypothesis or a meaningful conclusion. Many ChIP-seq datasets had been deposited on the public domain to help researchers make new discoveries. However, researches are often intimidated by the complexity of data structure and largeness of data volume. Such information would be more useful if they could be combined or downloaded with ChIP-seq data. To meet such demands, we built a webtool: ePIgenomic ANNOtation tool (ePIANNO, http://epianno.stat.sinica.edu.tw/index.html). ePIANNO is a web server that combines SNP information of populations (1000 Genomes Project) and gene-disease association information of GWAS (NHGRI) with ChIP-seq (hmChIP, ENCODE, and ROADMAP epigenomics) data. ePIANNO has a user-friendly website interface allowing researchers to explore, navigate, and extract data quickly. We use two examples to demonstrate how users could use functions of ePIANNO webserver to explore useful information about TF related genomic variants. Users could use our query functions to search target regions, transcription factors, or annotations. ePIANNO may help users to generate hypothesis or explore potential biological functions for their studies.

Effects of Reduced Terrestrial LiDAR Point Density on High-Resolution Grain Crop Surface Models in Precision Agriculture

PubMed Central

Hämmerle, Martin; Höfle, Bernhard

2014-01-01

3D geodata play an increasingly important role in precision agriculture, e.g., for modeling in-field variations of grain crop features such as height or biomass. A common data capturing method is LiDAR, which often requires expensive equipment and produces large datasets. This study contributes to the improvement of 3D geodata capturing efficiency by assessing the effect of reduced scanning resolution on crop surface models (CSMs). The analysis is based on high-end LiDAR point clouds of grain crop fields of different varieties (rye and wheat) and nitrogen fertilization stages (100%, 50%, 10%). Lower scanning resolutions are simulated by keeping every n-th laser beam with increasing step widths n. For each iteration step, high-resolution CSMs (0.01 m2 cells) are derived and assessed regarding their coverage relative to a seamless CSM derived from the original point cloud, standard deviation of elevation and mean elevation. Reducing the resolution to, e.g., 25% still leads to a coverage of >90% and a mean CSM elevation of >96% of measured crop height. CSM types (maximum elevation or 90th-percentile elevation) react differently to reduced scanning resolutions in different crops (variety, density). The results can help to assess the trade-off between CSM quality and minimum requirements regarding equipment and capturing set-up. PMID:25521383

Raster Vs. Point Cloud LiDAR Data Classification

NASA Astrophysics Data System (ADS)

El-Ashmawy, N.; Shaker, A.

2014-09-01

Airborne Laser Scanning systems with light detection and ranging (LiDAR) technology is one of the fast and accurate 3D point data acquisition techniques. Generating accurate digital terrain and/or surface models (DTM/DSM) is the main application of collecting LiDAR range data. Recently, LiDAR range and intensity data have been used for land cover classification applications. Data range and Intensity, (strength of the backscattered signals measured by the LiDAR systems), are affected by the flying height, the ground elevation, scanning angle and the physical characteristics of the objects surface. These effects may lead to uneven distribution of point cloud or some gaps that may affect the classification process. Researchers have investigated the conversion of LiDAR range point data to raster image for terrain modelling. Interpolation techniques have been used to achieve the best representation of surfaces, and to fill the gaps between the LiDAR footprints. Interpolation methods are also investigated to generate LiDAR range and intensity image data for land cover classification applications. In this paper, different approach has been followed to classifying the LiDAR data (range and intensity) for land cover mapping. The methodology relies on the classification of the point cloud data based on their range and intensity and then converted the classified points into raster image. The gaps in the data are filled based on the classes of the nearest neighbour. Land cover maps are produced using two approaches using: (a) the conventional raster image data based on point interpolation; and (b) the proposed point data classification. A study area covering an urban district in Burnaby, British Colombia, Canada, is selected to compare the results of the two approaches. Five different land cover classes can be distinguished in that area: buildings, roads and parking areas, trees, low vegetation (grass), and bare soil. The results show that an improvement of around 10 % in the

E6^E7, a Novel Splice Isoform Protein of Human Papillomavirus 16, Stabilizes Viral E6 and E7 Oncoproteins via HSP90 and GRP78

PubMed Central

Ajiro, Masahiko

2015-01-01

ABSTRACT Transcripts of human papillomavirus 16 (HPV16) E6 and E7 oncogenes undergo alternative RNA splicing to produce multiple splice isoforms. However, the importance of these splice isoforms is poorly understood. Here we report a critical role of E6^E7, a novel isoform containing the 41 N-terminal amino acid (aa) residues of E6 and the 38 C-terminal aa residues of E7, in the regulation of E6 and E7 stability. Through mass spectrometric analysis, we identified that HSP90 and GRP78, which are frequently upregulated in cervical cancer tissues, are two E6^E7-interacting proteins responsible for the stability and function of E6^E7, E6, and E7. Although GRP78 and HSP90 do not bind each other, GRP78, but not HSP90, interacts with E6 and E7. E6^E7 protein, in addition to self-binding, interacts with E6 and E7 in the presence of GRP78 and HSP90, leading to the stabilization of E6 and E7 by prolonging the half-life of each protein. Knocking down E6^E7 expression in HPV16-positive CaSki cells by a splice junction-specific small interfering RNA (siRNA) destabilizes E6 and E7 and prevents cell growth. The same is true for the cells with a GRP78 knockdown or in the presence of an HSP90 inhibitor. Moreover, mapping and alignment analyses for splicing elements in 36 alpha-HPVs (α-HPVs) suggest the possible expression of E6^E7 mostly by other oncogenic or possibly oncogenic α-HPVs (HPV18, -30, -31, -39, -42, -45, -56, -59, -70, and -73). HPV18 E6^E7 is detectable in HPV18-positive HeLa cells and HPV18-infected raft tissues. All together, our data indicate that viral E6^E7 and cellular GRP78 or HSP90 might be novel targets for cervical cancer therapy. PMID:25691589

Tree Canopy Cover Mapping Using LiDAR in Urban Barangays of Cebu City, Central Philippines

NASA Astrophysics Data System (ADS)

Ejares, J. A.; Violanda, R. R.; Diola, A. G.; Dy, D. T.; Otadoy, J. B.; Otadoy, R. E. S.

2016-06-01

This paper investigates tree canopy cover mapping of urban barangays (smallest administrative division in the Philippines) in Cebu City using LiDAR (Light Detection and Ranging). Object-Based Image Analysis (OBIA) was used to extract tree canopy cover. Multi-resolution segmentation and a series of assign-class algorithm in eCognition software was also performed to extract different land features. Contextual features of tree canopies such as height, area, roundness, slope, length-width and elliptic fit were also evaluated. The results showed that at the time the LiDAR data was collected (June 24, 2014), the tree cover was around 25.11 % (or 15,674,341.8 m2) of the city's urban barangays (or 62,426,064.6 m2). Among all urban barangays in Cebu City, Barangay Busay had the highest cover (55.79 %) while barangay Suba had the lowest (0.8 %). The 16 barangays with less than 10 % tree cover were generally located in the coastal area, presumably due to accelerated urbanization. Thirty-one barangays have tree cover ranging from 10.59--27.3 %. Only 3 barangays (i.e., Lahug, Talamban, and Busay) have tree cover greater than 30 %. The overall accuracy of the analysis was 96.6 % with the Kappa Index of Agreement or KIA of 0.9. From the study, a grouping can be made of the city's urban barangays with regards to tree cover. The grouping will be useful to urban planners not only in allocating budget to the tree planting program of the city but also in planning and creation of urban parks and playgrounds.

Estimation of forest aboveground biomass and uncertainties by integration of field measurements, airborne LiDAR, and SAR and optical satellite data in Mexico.

PubMed

Urbazaev, Mikhail; Thiel, Christian; Cremer, Felix; Dubayah, Ralph; Migliavacca, Mirco; Reichstein, Markus; Schmullius, Christiane

2018-02-21

Information on the spatial distribution of aboveground biomass (AGB) over large areas is needed for understanding and managing processes involved in the carbon cycle and supporting international policies for climate change mitigation and adaption. Furthermore, these products provide important baseline data for the development of sustainable management strategies to local stakeholders. The use of remote sensing data can provide spatially explicit information of AGB from local to global scales. In this study, we mapped national Mexican forest AGB using satellite remote sensing data and a machine learning approach. We modelled AGB using two scenarios: (1) extensive national forest inventory (NFI), and (2) airborne Light Detection and Ranging (LiDAR) as reference data. Finally, we propagated uncertainties from field measurements to LiDAR-derived AGB and to the national wall-to-wall forest AGB map. The estimated AGB maps (NFI- and LiDAR-calibrated) showed similar goodness-of-fit statistics (R 2 , Root Mean Square Error (RMSE)) at three different scales compared to the independent validation data set. We observed different spatial patterns of AGB in tropical dense forests, where no or limited number of NFI data were available, with higher AGB values in the LiDAR-calibrated map. We estimated much higher uncertainties in the AGB maps based on two-stage up-scaling method (i.e., from field measurements to LiDAR and from LiDAR-based estimates to satellite imagery) compared to the traditional field to satellite up-scaling. By removing LiDAR-based AGB pixels with high uncertainties, it was possible to estimate national forest AGB with similar uncertainties as calibrated with NFI data only. Since LiDAR data can be acquired much faster and for much larger areas compared to field inventory data, LiDAR is attractive for repetitive large scale AGB mapping. In this study, we showed that two-stage up-scaling methods for AGB estimation over large areas need to be analyzed and validated

Experiment E89-044 on the Quasielastic 3He(e,e'p) Reaction at Jefferson Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penel-Nottaris, Emilie

The Jefferson Lab Hall A E89-044 experiment has measured the 3He(e,e'p) reaction cross-sections. The extraction of the longitudinal and transverse response functions for the two-body break-up 3He(e,e'p)d reaction in parallel kinematics allows the study of the bound proton electromagnetic properties inside the 3He nucleus and the involved nuclear mechanisms beyond plane wave approximations.

Semi-automated stand delineation in Mediterranean Pinus sylvestris plantations through segmentation of LiDAR data: The influence of pulse density

NASA Astrophysics Data System (ADS)

Varo-Martínez, Mª Ángeles; Navarro-Cerrillo, Rafael M.; Hernández-Clemente, Rocío; Duque-Lazo, Joaquín

2017-04-01

Traditionally, forest-stand delineation has been assessed based on orthophotography. The application of LiDAR has improved forest management by providing high-spatial-resolution data on the vertical structure of the forest. The aim of this study was to develop and test a semi-automated algorithm for stands delineation in a plantation of Pinus sylvestris L. using LiDAR data. Three specific objectives were evaluated, i) to assess two complementary LiDAR metrics, Assmann dominant height and basal area, for the characterization of the structure of P. sylvestris Mediterranean forests based on object-oriented segmentation, ii) to evaluate the influence of the LiDAR pulse density on forest-stand delineation accuracy, and iii) to investigate the algorithmś effectiveness in the delineation of P. sylvestris stands for map prediction of Assmann dominant height and basal area. Our results show that it is possible to generate accurate P. sylvestris forest-stand segmentations using multiresolution or mean shift segmentation methods, even with low-pulse-density LiDAR - which is an important economic advantage for forest management. However, eCognition multiresolution methods provided better results than the OTB (Orfeo Tool Box) for stand delineation based on dominant height and basal area estimations. Furthermore, the influence of pulse density on the results was not statistically significant in the basal area calculations. However, there was a significant effect of pulse density on Assmann dominant height [F2,9595 = 5.69, p = 0.003].for low pulse density. We propose that the approach shown here should be considered for stand delineation in other large Pinus plantations in Mediterranean regions with similar characteristics.

Waveform LiDAR across forest biomass gradients

NASA Astrophysics Data System (ADS)

Montesano, P. M.; Nelson, R. F.; Dubayah, R.; Sun, G.; Ranson, J.

2011-12-01

Detailed information on the quantity and distribution of aboveground biomass (AGB) is needed to understand how it varies across space and changes over time. Waveform LiDAR data is routinely used to derive the heights of scattering elements in each illuminated footprint, and the vertical structure of vegetation is related to AGB. Changes in LiDAR waveforms across vegetation structure gradients can demonstrate instrument sensitivity to land cover transitions. A close examination of LiDAR waveforms in footprints across a forest gradient can provide new insight into the relationship of vegetation structure and forest AGB. In this study we use field measurements of individual trees within Laser Vegetation Imaging Sensor (LVIS) footprints along transects crossing forest to non-forest gradients to examine changes in LVIS waveform characteristics at sites with low (< 50Mg/ha) AGB. We relate field AGB measurements to original and adjusted LVIS waveforms to detect the forest AGB interval along a forest - non-forest transition in which the LVIS waveform lose the ability to discern differences in AGB. Our results help identify the lower end the forest biomass range that a ~20m footprint waveform LiDAR can detect, which can help infer accumulation of biomass after disturbances and during forest expansion, and which can guide the use of LiDAR within a multi-sensor fusion biomass mapping approach.

Weibel instability for a streaming electron, counterstreaming e-e, and e-p plasmas with intrinsic temperature anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ghorbanalilu, M.; Physics Department, Azarbaijan Shahid Madani University, Tabriz; Sadegzadeh, S.

2014-05-15

The existence of Weibel instability for a streaming electron, counterstreaming electron-electron (e-e), and electron-positron (e-p) plasmas with intrinsic temperature anisotropy is investigated. The temperature anisotropy is included in the directions perpendicular and parallel to the streaming direction. It is shown that the beam mean speed changes the instability mode, for a streaming electron beam, from the classic Weibel to the Weibel-like mode. The analytical and numerical solutions approved that Weibel-like modes are excited for both counterstreaming e-e and e-p plasmas. The growth rates of the instabilities in e-e and e-p plasmas are compared. The growth rate is larger for e-pmore » plasmas if the thermal anisotropy is small and the opposite is true for large thermal anisotropies. The analytical and numerical solutions are in good agreement only in the small parallel temperature and wave number limits, when the instability growth rate increases linearly with normalized wave number kc∕ω{sub p}.« less

The key particle and quark energy equality E W + E Z = E top

NASA Astrophysics Data System (ADS)

Mac Gregor, Malcolm H.

2017-11-01

Precision Tevatron and Linear Hadron Collider measurements at Fermilab and CERN have revealed the numerically accurate mass equality W + Z = t. This equality between two gauge bosons ( gb) and the top quark t is only valid if reinterpreted as an energy equality, where E = mc 2, since energy is a shared property of particles and quarks. The experimental data indicate that the LHC particle excitation energy is quantized in the form of gauge boson energy packets E gb , which are created by factor-of-137 proton-quark energy increases denoted as α- boosts, where α 1/137 is the fine structure constant. These α-boosts occur during the rare head-on quark-quark collisions in the proton beams. The α-boost energy quantization mechanism also occurs in low-energy electron-positron boson and fermion particle production channels, where it generates E b and E f energy packets. These α-boost energy channels link together coherently, as demonstrated by the accurate top quark energy equation E top = (18/α2) E electron. Particle production energy equations are derived which combine to create an overall energy pattern that accurately reproduces the energies of the ( u, d), s, c, b, t fermion constituent quarks, the µ and τ leptons, and the proton.

Search for rare and forbidden decays D+ --> h+/- e+/- e+.

PubMed

He, Q; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Wilksen, T; Weaver, K M; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Williams, J; Wiss, J; Asner, D M; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Cravey, M; Cummings, J P; Danko, I; Napolitano, J

2005-11-25

Using 0.8 x 10(6) D+ D- pairs collected with the CLEO-c detector at the psi(3770) resonance, we have searched for flavor-changing neutral current and lepton-number-violating decays of D+ mesons to final states with dielectrons. We find no indication of either, obtaining 90% confidence level upper limits of B(D+ --> pi+ e+ e-) < 7.4 x 10(-6), B(D+ --> pi- e+ d+) < 3.6 x 10(-6), B(D+ --> K+ e+ e-) < 6.2 x 10(-6), and B(D+ --> K- e+ e+) < 4.5 x 10(-6).

To the Application of LiDAR to Detect the Geological Structures in Sulphurets Property, British Columbia, Canada

NASA Astrophysics Data System (ADS)

Koohzare, A.; Rezaeian, M.; McIntosh, A.

2009-05-01

The Kerr Sulphurets property in North Western British Columbia has been explored primarily as a placer gold holding since the 1880s; and, potentially includes one of Canada's largest gold deposits (e.g. the Mitchell Zone). The Sulphurets camp has been classified by Taylor in 2007 as a prominent global epithermal high-sulphidation subtype with 10 million tonnes of ore (reserves + production) containing approximately 10 g/t gold. The geological and geophysical observations of this deposit indicate intrusion- related mineralized veins which are known to overlap as the result of structural complexities. Faulting predates mineralization and alteration and dramatically dominates the location of the mineralization for this porphyry- epithermal high-sulphidation deposit (Britton and Alldrick 1988, British Columbia Ministry of Energy, Mines and Petroleum Resources, 1992; Margolis, 1993). However, the surface trace of these structures and lineaments within the site is obscured by vegetation, glacial cover and steep topographic relief. We used high resolution LiDAR airborne bare-earth sensing (vegetative data deleted) in an effort to detect the surface geological features and lineaments in the Kerr Sulphurets site. The LiDAR flight was designed to acquire high density data with 2 points per square meter using a 150 kHz multipulse system. High resolution LiDAR data provides a level of detail not achievable by other digital terrain modelling techniques, whether extracted from aerial photography, low-resolution topographic contour maps, 10-30 meter USGS, or SRTM digital elevation models. LiDAR bare-earth data spectacularly revealed hidden geological structures within the property district, which in turn assisted in identifying the high potential zones for mineralization in Sulphurets.

Classifying Autism Spectrum Disorders by ADI-R: Subtypes or Severity Gradient?

ERIC Educational Resources Information Center

Cholemkery, Hannah; Medda, Juliane; Lempp, Thomas; Freitag, Christine M.

2016-01-01

To reduce phenotypic heterogeneity of Autism spectrum disorders (ASD) and add to the current diagnostic discussion this study aimed at identifying clinically meaningful ASD subgroups. Cluster analyses were used to describe empirically derived groups based on the Autism Diagnostic Interview-revised (ADI-R) in a large sample of n = 463 individuals…

E-Service Quality, E-Satisfaction and E-Loyalty of Online Shoppers in Business to Consumer Market; Evidence form Malaysia

NASA Astrophysics Data System (ADS)

Ting, Ong Soo; Ariff, Mohd Shoki Md; Zakuan, Norhayati; Sulaiman, Zuraidah; Zameri Mat Saman, Muhamad

2016-05-01

The growing usage of internet and online shopping in Malaysia presents a huge prospect in e-commerce market, specifically for B2C segment. As a result, electronic service quality (e-SQ), electronic satisfaction (e-Satisfaction) and electronic loyalty (e-Loyalty) become vital for online retailers to attract and retain online shoppers in this virtual environment. The association between e-SQ, e-Satisfaction and e-Loyalty should be continuously examined to cope with the advancement in information and communication technology, and the changing expectation of online shoppers. However, construct of e-SQ for online retailers in B2C market is still debatable. In this research, E-SERVQUAL was integrated with the other e-SQ scales to measure e-SQ of a prominent online retailer in Malaysia. Specifically, the e-SQ constructs are Efficiency, Privacy and Trust, Fulfilment, Responsiveness, Contact and Website Design. 390 sets of completed and usable questionnaires were gathered using online questionnaire and convenience sampling procedure. The result indicated that the five proposed dimensions of e-SQ constitute e-SQ of online retailer in B2C market. All the dimensions of e-SQ were found to have positive and significant effect on e-Satisfaction of online shoppers. Responsiveness of e-SQ had the strongest impact on e-satisfaction of online shoppers. The shoppers e-Satisfaction was positively and significantly affected their e-Loyalty towards continuous usage of online retailer's website. Managerial and theoretical implications are discussed based on the results of the study.

eCX: A Secure Infrastructure for E-Course Delivery.

ERIC Educational Resources Information Center

Yau, Joe C. K; Hui, Lucas C. K.; Cheung, Bruce; Yiu, S. M.

2003-01-01

Presents a mechanism, the Secure e-Course eXchange (eCX) designed to protect learning material from unauthorized dissemination, and shows how this mechanism can be integrated in the operation model of online learning course providers. The design of eCX is flexible to fit two operating models, the Institutional Server Model and the Corporate Server…

Search for the rare decays J / ψ → D 0 e + e − + c . c . and ψ ( 3686 ) → D 0 e + e − + c . c .

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2017-12-01

Using the data samples of (1310.6 ± 7.2) × 10 6 J / ψ events and (448.1 ± 2.9) × 106 (3686) events collected with the BESIII detector, we search for the rare decays J / ψ → D 0e +e - + c.c. and (3686) → D 0e +e - + c.c.. No significant signals are observed and the corresponding upper limits on the branching fractions at the 90% confidence level are determined to be B( J /more » ψ → D0e+e- + c.c.) < 8.5 × 10 -8 and B( (3686) → D0e+e- + c.c.) < 1.4 × 10 -7, respectively. Our limit on B( J / ψ → D 0e +e - + c.c.) is more stringent by two orders of magnitude than the previous results, and the B( (3686) → D 0e +e - + c.c.) is measured for the first time. « less

Search for the rare decays J / ψ → D 0 e + e − + c . c . and ψ ( 3686 ) → D 0 e + e − + c . c .

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

Using the data samples of (1310.6 ± 7.2) × 10 6 J / ψ events and (448.1 ± 2.9) × 106 (3686) events collected with the BESIII detector, we search for the rare decays J / ψ → D 0e +e - + c.c. and (3686) → D 0e +e - + c.c.. No significant signals are observed and the corresponding upper limits on the branching fractions at the 90% confidence level are determined to be B( J /more » ψ → D0e+e- + c.c.) < 8.5 × 10 -8 and B( (3686) → D0e+e- + c.c.) < 1.4 × 10 -7, respectively. Our limit on B( J / ψ → D 0e +e - + c.c.) is more stringent by two orders of magnitude than the previous results, and the B( (3686) → D 0e +e - + c.c.) is measured for the first time. « less

Detecting Inspection Objects of Power Line from Cable Inspection Robot LiDAR Data

PubMed Central

Qin, Xinyan; Wu, Gongping; Fan, Fei

2018-01-01

Power lines are extending to complex environments (e.g., lakes and forests), and the distribution of power lines in a tower is becoming complicated (e.g., multi-loop and multi-bundle). Additionally, power line inspection is becoming heavier and more difficult. Advanced LiDAR technology is increasingly being used to solve these difficulties. Based on precise cable inspection robot (CIR) LiDAR data and the distinctive position and orientation system (POS) data, we propose a novel methodology to detect inspection objects surrounding power lines. The proposed method mainly includes four steps: firstly, the original point cloud is divided into single-span data as a processing unit; secondly, the optimal elevation threshold is constructed to remove ground points without the existing filtering algorithm, improving data processing efficiency and extraction accuracy; thirdly, a single power line and its surrounding data can be respectively extracted by a structured partition based on a POS data (SPPD) algorithm from “layer” to “block” according to power line distribution; finally, a partition recognition method is proposed based on the distribution characteristics of inspection objects, highlighting the feature information and improving the recognition effect. The local neighborhood statistics and the 3D region growing method are used to recognize different inspection objects surrounding power lines in a partition. Three datasets were collected by two CIR LIDAR systems in our study. The experimental results demonstrate that an average 90.6% accuracy and average 98.2% precision at the point cloud level can be achieved. The successful extraction indicates that the proposed method is feasible and promising. Our study can be used to obtain precise dimensions of fittings for modeling, as well as automatic detection and location of security risks, so as to improve the intelligence level of power line inspection. PMID:29690560

Detecting Inspection Objects of Power Line from Cable Inspection Robot LiDAR Data.

PubMed

Qin, Xinyan; Wu, Gongping; Lei, Jin; Fan, Fei; Ye, Xuhui

2018-04-22

Power lines are extending to complex environments (e.g., lakes and forests), and the distribution of power lines in a tower is becoming complicated (e.g., multi-loop and multi-bundle). Additionally, power line inspection is becoming heavier and more difficult. Advanced LiDAR technology is increasingly being used to solve these difficulties. Based on precise cable inspection robot (CIR) LiDAR data and the distinctive position and orientation system (POS) data, we propose a novel methodology to detect inspection objects surrounding power lines. The proposed method mainly includes four steps: firstly, the original point cloud is divided into single-span data as a processing unit; secondly, the optimal elevation threshold is constructed to remove ground points without the existing filtering algorithm, improving data processing efficiency and extraction accuracy; thirdly, a single power line and its surrounding data can be respectively extracted by a structured partition based on a POS data (SPPD) algorithm from "layer" to "block" according to power line distribution; finally, a partition recognition method is proposed based on the distribution characteristics of inspection objects, highlighting the feature information and improving the recognition effect. The local neighborhood statistics and the 3D region growing method are used to recognize different inspection objects surrounding power lines in a partition. Three datasets were collected by two CIR LIDAR systems in our study. The experimental results demonstrate that an average 90.6% accuracy and average 98.2% precision at the point cloud level can be achieved. The successful extraction indicates that the proposed method is feasible and promising. Our study can be used to obtain precise dimensions of fittings for modeling, as well as automatic detection and location of security risks, so as to improve the intelligence level of power line inspection.

Assessing LiDAR elevation data for KDOT applications.

DOT National Transportation Integrated Search

2013-02-01

LiDAR-based elevation surveys are a cost-effective means for mapping topography over large areas. LiDAR : surveys use an airplane-mounted or ground-based laser radar unit to scan terrain. Post-processing techniques are : applied to remove vegetation ...

LiDAR and Image Point Cloud Comparison

DTIC Science & Technology

2014-09-01

UAV unmanned aerial vehicle USGS United States Geological Survey UTM Universal Transverse Mercator WGS 84 World Geodetic System 1984 WSI...19  1.  Physics of LiDAR Systems ................................................................20  III.  DATA AND SOFTWARE...ground control point GPS Global Positioning System IMU inertial measurements unit LiDAR light detection and ranging MI mutual information MVS

17 CFR 402.2e - Appendix E-Temporary minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Appendix E-Temporary minimum requirements. 402.2e Section 402.2e Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2e Appendix E...

17 CFR 402.2e - Appendix E-Temporary minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Appendix E-Temporary minimum requirements. 402.2e Section 402.2e Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2e Appendix E...

17 CFR 402.2e - Appendix E-Temporary minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Appendix E-Temporary minimum requirements. 402.2e Section 402.2e Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2e Appendix E...

17 CFR 402.2e - Appendix E-Temporary minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Appendix E-Temporary minimum requirements. 402.2e Section 402.2e Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2e Appendix E...

17 CFR 402.2e - Appendix E-Temporary minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Appendix E-Temporary minimum requirements. 402.2e Section 402.2e Commodity and Securities Exchanges DEPARTMENT OF THE TREASURY REGULATIONS UNDER SECTION 15C OF THE SECURITIES EXCHANGE ACT OF 1934 FINANCIAL RESPONSIBILITY § 402.2e Appendix E...

Recall of E-cigarette Advertisements and Adolescent E-cigarette Use.

PubMed

Nicksic, Nicole E; Harrell, Melissa B; Pérez, Adriana; Pasch, Keryn E; Perry, Cheryl L

2017-04-01

We examined the impact of e-cigarette advertising on e-cigarette use behaviors among youth over time. At baseline, 3907 students participated in a youth tobacco surveillance study from 2014-2015 and 2488 students completed a 6-month follow-up. Weighted logistic regression models investigated the recall of e-cigarette advertisements (TV/radio/billboards/retail/Internet) as a risk factor for e-cigarette perceived harm, use, and susceptibility. The odds of ever e-cigarette use was 3 times higher (AOR=2.99; 95% CI, 1.50-5.97) at 6-month follow-up among e-cigarette never-users who recalled e-cigarette advertisements in retail stores at baseline, compared to those who did not. Likewise, the odds of current e-cigarette use and susceptibility to e-cigarette use at 6-month follow-up were 2.03 (95% CI, 1.11-3.72) and 1.77 (95% CI, 1.20-2.61), respectively. Additionally, recall of e-cigarette advertisements on the Internet at baseline was significantly related to current use (AOR=2.17; 95% CI, 1.05-4.48) and susceptibility to use e-cigarettes (AOR=1.72;95% CI, 1.15-2.58) at 6-month follow-up. Recall of e-cigarette advertisements at point-of-sale and on the Internet was significantly associated with adolescent e-cigarette susceptibility and use, which supports the need to minimize adolescent exposure to these advertisements.

Recall of E-cigarette Advertisements and Adolescent E-cigarette Use

PubMed Central

Nicksic, Nicole E.; Harrell, Melissa B.; Pérez, Adriana; Pasch, Keryn E.; Perry, Cheryl L.

2017-01-01

Objective We examined the impact of e-cigarette advertising on e-cigarette use behaviors among youth over time. Methods At baseline, 3907 students participated in a youth tobacco surveillance study from 2014–2015 and 2488 students completed a 6-month follow-up. Weighted logistic regression models investigated the recall of e-cigarette advertisements (TV/radio/billboards/retail/Internet) as a risk factor for e-cigarette perceived harm, use, and susceptibility. Results The odds of ever e-cigarette use was 3 times higher (AOR=2.99; 95% CI, 1.50–5.97) at 6-month follow-up among e-cigarette never-users who recalled e-cigarette advertisements in retail stores at baseline, compared to those who did not. Likewise, the odds of current e-cigarette use and susceptibility to e-cigarette use at 6-month follow-up were 2.03 (95% CI, 1.11–3.72) and 1.77 (95% CI, 1.20–2.61), respectively. Additionally, recall of e-cigarette advertisements on the Internet at baseline was significantly related to current use (AOR=2.17; 95% CI, 1.05–4.48) and susceptibility to use e-cigarettes (AOR=1.72;95% CI, 1.15–2.58) at 6-month follow-up. Conclusions Recall of e-cigarette advertisements at point-of-sale and on the Internet was significantly associated with adolescent e-cigarette susceptibility and use, which supports the need to minimize adolescent exposure to these advertisements. PMID:29104901

From E-Learning Space to E-Learning Place

ERIC Educational Resources Information Center

Wahlstedt, Ari; Pekkola, Samuli; Niemela, Marketta

2008-01-01

In this paper, it is argued that e-learning environments are currently more like "buildings", i.e., learning spaces, rather than "schools", i.e., places for learning. The concepts originated from architecture and urban design, where they are used both to distinguish static spaces from inhabited places, and more importantly, as design objectives.…

Georeferenced LiDAR 3D vine plantation map generation.

PubMed

Llorens, Jordi; Gil, Emilio; Llop, Jordi; Queraltó, Meritxell

2011-01-01

The use of electronic devices for canopy characterization has recently been widely discussed. Among such devices, LiDAR sensors appear to be the most accurate and precise. Information obtained with LiDAR sensors during reading while driving a tractor along a crop row can be managed and transformed into canopy density maps by evaluating the frequency of LiDAR returns. This paper describes a proposed methodology to obtain a georeferenced canopy map by combining the information obtained with LiDAR with that generated using a GPS receiver installed on top of a tractor. Data regarding the velocity of LiDAR measurements and UTM coordinates of each measured point on the canopy were obtained by applying the proposed transformation process. The process allows overlap of the canopy density map generated with the image of the intended measured area using Google Earth(®), providing accurate information about the canopy distribution and/or location of damage along the rows. This methodology was applied and tested on different vine varieties and crop stages in two important vine production areas in Spain. The results indicate that the georeferenced information obtained with LiDAR sensors appears to be an interesting tool with the potential to improve crop management processes.

E-Learning 2010: E-Educators Evolving

ERIC Educational Resources Information Center

Bushweller, Kevin, Ed.

2010-01-01

This special report, the second in a three-part series on e-learning, aims to answer questions related to the growing role of e-educators in K-12 education. It provides perspectives and advice from state policymakers and virtual school providers navigating through the new and often murky policy waters of online-only education, and features…

E. coli

MedlinePlus

... concerns about E. coli . E. coli and Raw Cookie Dough FDA Continues to Warn Against Eating Raw Dough ... Reminds consumers about the risks of eating raw cookie dough. Multistate Outbreak of E. coli O157:H7 Infections ...

20-Hydroxyecdysone (20E) Primary Response Gene E93 Modulates 20E Signaling to Promote Bombyx Larval-Pupal Metamorphosis*

PubMed Central

Liu, Xi; Dai, Fangyin; Guo, Enen; Li, Kang; Ma, Li; Tian, Ling; Cao, Yang; Zhang, Guozheng; Palli, Subba R.; Li, Sheng

2015-01-01

As revealed in a previous microarray study to identify genes regulated by 20-hydroxyecdysone (20E) and juvenile hormone (JH) in the silkworm, Bombyx mori, E93 expression in the fat body was markedly low prior to the wandering stage but abundant during larval-pupal metamorphosis. Induced by 20E and suppressed by JH, E93 expression follows this developmental profile in multiple silkworm alleles. The reduction of E93 expression by RNAi disrupted 20E signaling and the 20E-induced autophagy, caspase activity, and cell dissociation in the fat body. Reducing E93 expression also decreased the expression of the 20E-induced pupal-specific cuticle protein genes and prevented growth and differentiation of the wing discs. Importantly, the two HTH domains in E93 are critical for inducing the expression of a subset of 20E response genes, including EcR, USP, E74, Br-C, and Atg1. By contrast, the LLQHLL and PLDLSAK motifs in E93 inhibit its transcriptional activity. E93 binds to the EcR-USP complex via a physical association with USP through its LLQHLL motif; and this association is enhanced by 20E-induced EcR-USP interaction, which attenuates the transcriptional activity of E93. E93 acts through the two HTH domains to bind to GAGA-containing motifs present in the Atg1 promoter region for inducing gene expression. In conclusion, E93 transcriptionally modulates 20E signaling to promote Bombyx larval-pupal metamorphosis. PMID:26378227

20-Hydroxyecdysone (20E) Primary Response Gene E93 Modulates 20E Signaling to Promote Bombyx Larval-Pupal Metamorphosis.

PubMed

Liu, Xi; Dai, Fangyin; Guo, Enen; Li, Kang; Ma, Li; Tian, Ling; Cao, Yang; Zhang, Guozheng; Palli, Subba R; Li, Sheng

2015-11-06

As revealed in a previous microarray study to identify genes regulated by 20-hydroxyecdysone (20E) and juvenile hormone (JH) in the silkworm, Bombyx mori, E93 expression in the fat body was markedly low prior to the wandering stage but abundant during larval-pupal metamorphosis. Induced by 20E and suppressed by JH, E93 expression follows this developmental profile in multiple silkworm alleles. The reduction of E93 expression by RNAi disrupted 20E signaling and the 20E-induced autophagy, caspase activity, and cell dissociation in the fat body. Reducing E93 expression also decreased the expression of the 20E-induced pupal-specific cuticle protein genes and prevented growth and differentiation of the wing discs. Importantly, the two HTH domains in E93 are critical for inducing the expression of a subset of 20E response genes, including EcR, USP, E74, Br-C, and Atg1. By contrast, the LLQHLL and PLDLSAK motifs in E93 inhibit its transcriptional activity. E93 binds to the EcR-USP complex via a physical association with USP through its LLQHLL motif; and this association is enhanced by 20E-induced EcR-USP interaction, which attenuates the transcriptional activity of E93. E93 acts through the two HTH domains to bind to GAGA-containing motifs present in the Atg1 promoter region for inducing gene expression. In conclusion, E93 transcriptionally modulates 20E signaling to promote Bombyx larval-pupal metamorphosis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Emissions & Generation Resource Integrated Database (eGRID), eGRID2012

EPA Pesticide Factsheets

The Emissions & Generation Resource Integrated Database (eGRID) is a comprehensive source of data on the environmental characteristics of almost all electric power generated in the United States. These environmental characteristics include air emissions for nitrogen oxides, sulfur dioxide, carbon dioxide, methane, and nitrous oxide; emissions rates; net generation; resource mix; and many other attributes. eGRID2012 Version 1.0 is the eighth edition of eGRID, which contains the complete release of year 2009 data, as well as year 2007, 2005, and 2004 data. For year 2009 data, all the data are contained in a single Microsoft Excel workbook, which contains boiler, generator, plant, state, power control area, eGRID subregion, NERC region, U.S. total and grid gross loss factor tabs. Full documentation, summary data, eGRID subregion and NERC region representational maps, and GHG emission factors are also released in this edition. The fourth edition of eGRID, eGRID2002 Version 2.01, containing year 1996 through 2000 data is located on the eGRID Archive page (http://www.epa.gov/cleanenergy/energy-resources/egrid/archive.html). The current edition of eGRID and the archived edition of eGRID contain the following years of data: 1996 - 2000, 2004, 2005, and 2007. eGRID has no other years of data.

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

PubMed Central

Attar-Schneider, Oshrat; Pasmanik-Chor, Metsada; Tartakover-Matalon, Shelly

2015-01-01

Accumulating data indicate translation plays a role in cancer biology, particularly its rate limiting stage of initiation. Despite this evolving recognition, the function and importance of specific translation initiation factors is unresolved. The eukaryotic translation initiation complex eIF4F consists of eIF4E and eIF4G at a 1:1 ratio. Although it is expected that they display interdependent functions, several publications suggest independent mechanisms. This study is the first to directly assess the relative contribution of eIF4F components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in a malignancy known for extensive protein synthesis-multiple myeloma (MM). Previously, we have shown that eIF4E/eIF4GI attenuation (siRNA/Avastin) deleteriously affected MM cells' fate and reduced levels of eIF4E/eIF4GI established targets. Here, we demonstrated that eIF4E/eIF4GI indeed have individual influences on cell proteome. We used an objective, high throughput assay of mRNA microarrays to examine the significance of eIF4E/eIF4GI silencing to several cellular facets such as transcription factors, microRNAs and phenotype. We showed different imprints for eIF4E and eIF4GI in all assayed aspects. These results promote our understanding of the relative contribution and importance of eIF4E and eIF4GI to the malignant phenotype and shed light on their function in eIF4F translation initiation complex. PMID:25717031

E-Cigarette Users' Attitudes on the Banning of Sales of Nicotine E-Liquid, Its Implication on E-Cigarette Use Behaviours and Alternative Sources of Nicotine E-Liquid.

PubMed

Wong, Li Ping; Alias, Haridah; Agha Mohammadi, Nasrin; Ghadimi, Azadeh; Hoe, Victor Chee Wai

2017-12-01

The banning of sales of nicotine e-liquid in e-cigarette shops has been implemented in several states in Malaysia. The distribution of nicotine e-liquid can only be allowed by licensed pharmacies or registered medical practitioners. This study aimed to evaluate e-cigarette users' responses to the control policy in a cross-sectional survey of 851 e-cigarette users by utilizing a self-report questionnaire that assessed (1) attitudes on regulation policy of e-cigarette banning; (2) e-cigarette use behaviors; and (3) sources of e-liquid after the regulation policy has been implemented. Participants from the state of Selangor where the banning policy was implemented were surveyed. The majority (95.8%) opposed the banning and believed e-cigarettes should be sold to anyone aged 18 years or above as with tobacco cigarettes, only a minority believed that nicotine e-liquid should only be available for sale over the counter in pharmacy stores (14.6%) and in clinics with a doctor's prescription (11.8%). The majority (44.2%) reported that they would continue their e-cigarette use as before the banning policy, while 20% plan to completely stop e-cigarette usage without replacing it with any alternatives. The vast majority (87.9%) was still able to obtained nicotine e-liquid from e-cigarette shops in spite of the ban and the second most common source was from online purchase (63.1%). The sales of nicotine e-liquid from black-market were evidenced as many reported obtaining zero nicotine e-liquid from the black market (54.4%). Self- or home-made (30.8%) nicotine e-liquid was also reported. Majority of respondents that self-made e-liquid were from the average monthly income group (below MYR3000). Obtaining nicotine from the pharmacy was least preferred (21.4%). Provision of professional advice to nicotine e-liquid users along with the ban may lessen the likelihood of users switching to tobacco cigarettes or other nicotine alternatives. Banning of sales of nicotine e-liquid in e

Spin and chirality effects in antler-topology processes at high energy $$\\varvec{e^+e^-}$$ e + e - colliders

DOE PAGES

Choi, S. Y.; Christensen, N. D.; Salmon, D.; ...

2015-10-01

We perform a model-independent investigation of spin and chirality correlation effects in the antler-topology processes e+e−→P+P−→(ℓ+D0)(ℓ−D¯0) at high-energy e+e− colliders with polarized beams. Generally the production process e+e−→P+P− can occur not only through the s-channel exchange of vector bosons, V0 , including the neutral Standard Model (SM) gauge bosons, γ and Z, but also through the s- and t-channel exchanges of new neutral states, S0 and T0 , and the u-channel exchange of new doubly charged states, U−− . The general set of (non-chiral) three-point couplings of the new particles and leptons allowed in a renormalizable quantum field theory ismore » considered. The general spin and chirality analysis is based on the threshold behavior of the excitation curves for P+P− pair production in e+e− collisions with longitudinal- and transverse-polarized beams, the angular distributions in the production process and also the production-decay angular correlations. In the first step, we present the observables in the helicity formalism. Subsequently, we show how a set of observables can be designed for determining the spins and chiral structures of the new particles without any model assumptions. Finally, taking into account a typical set of approximately chiral invariant scenarios, we demonstrate how the spin and chirality effects can be probed experimentally at a high-energy e+e− collider.« less

Search for the decays B_{(s)};{0} --> e;{+} micro;{-} and B_{(s)};{0} --> e;{+} e;{-} in CDF run II.

PubMed

Aaltonen, T; Adelman, J; Akimoto, T; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurri, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burke, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cordelli, M; Cortiana, G; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heijboer, A; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, S W; Leone, S; Lewis, J D; Lin, C-S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lucchesi, D; Luci, C; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Griso, S Pagan; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Stuart, D; Suh, J S; Sukhanov, A; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wenzel, H; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Würthwein, F; Xie, S; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zhang, X; Zheng, Y; Zucchelli, S

2009-05-22

We report results from a search for the lepton flavor violating decays B_{s};{0} --> e;{+} micro;{-} and B;{0} --> e;{+} micro;{-}, and the flavor-changing neutral-current decays B_{s};{0} --> e;{+} e;{-} and B;{0} --> e;{+} e;{-}. The analysis uses data corresponding to 2 fb;{-1} of integrated luminosity of pp[over ] collisions at sqrt[s] = 1.96 TeV collected with the upgraded Collider Detector (CDF II) at the Fermilab Tevatron. The observed number of B0 and B_{s};{0} candidates is consistent with background expectations. The resulting Bayesian upper limits on the branching ratios at 90% credibility level are B(B_{s};{0} --> e;{+} micro;{-}) < 2.0 x 10;{-7}, B(B;{0} --> e;{+} micro;{-}) < 6.4 x 10;{-8}, B(B_{s};{0} --> e;{+} e;{-}) < 2.8 x 10;{-7}, and B(B;{0} --> e;{+} e;{-}) < 8.3 x 10;{-8}. From the limits on B(B_{(s)};{0} --> e;{+} micro;{-}), the following lower bounds on the Pati-Salam leptoquark masses are also derived: M_{LQ}(B_{s};{0} --> e;{+} micro;{-}) > 47.8 TeV/c;{2}, and M_{LQ}(B;{0} --> e;{+} micro;{-}) > 59.3 TeV / c;{2}, at 90% credibility level.

Metadata Sets for e-Government Resources: The Extended e-Government Metadata Schema (eGMS+)

NASA Astrophysics Data System (ADS)

Charalabidis, Yannis; Lampathaki, Fenareti; Askounis, Dimitris

In the dawn of the Semantic Web era, metadata appear as a key enabler that assists management of the e-Government resources related to the provision of personalized, efficient and proactive services oriented towards the real citizens’ needs. As different authorities typically use different terms to describe their resources and publish them in various e-Government Registries that may enhance the access to and delivery of governmental knowledge, but also need to communicate seamlessly at a national and pan-European level, the need for a unified e-Government metadata standard emerges. This paper presents the creation of an ontology-based extended metadata set for e-Government Resources that embraces services, documents, XML Schemas, code lists, public bodies and information systems. Such a metadata set formalizes the exchange of information between portals and registries and assists the service transformation and simplification efforts, while it can be further taken into consideration when applying Web 2.0 techniques in e-Government.

WW Physics at Future e{sup +}e{sup -} Linear Colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barklow, Timothy L

Measurements of triple gauge boson couplings and strong electroweak symmetry breaking effects at future e{sup +}e{sup -} linear colliders are reviewed. The results expected from a future e{sup +}e{sup -} linear collider are compared with LHC expectations.

Impact of e-liquid flavors on e-cigarette vaping behavior.

PubMed

St Helen, Gideon; Shahid, Marian; Chu, Sherman; Benowitz, Neal L

2018-05-31

The primary objective of this pilot study was to describe the impact of e-cigarette liquid flavors on experienced e-cigarette users' vaping behavior. 11 males and 3 females participated in a 3-day inpatient crossover study using e-cigarettes with strawberry, tobacco, and their usual brand e-liquid. Nicotine levels were nominally 18 mg/mL in the strawberry and tobacco e-liquids and ranged between 3-18 mg/mL in the usual brands. On each day, participants had access to the study e-cigarette (KangerTech mini ProTank 3, 1.5 Ohms, 3.7 V) and the assigned e-liquid during a 90-minute videotaped ad libitum session. Average puff duration was significantly longer when using the strawberry e-liquid (3.2 ± 1.3 s, mean ± SD) compared to the tobacco e-liquid (2.8 ± 1.1 s) but the average number of puffs was not significantly different (strawberry, 73 ± 35; tobacco, 69 ± 46). Compared to the strawberry- and tobacco-flavored e-liquids, average puff duration was significantly longer (4.3 ± 1.6 s) and the average number of puffs was significantly higher (106 ± 67 puffs) when participants used their usual brand of e-liquid. Participants generally puffed more frequently in small groups of puffs (1-5 puffs) with the strawberry compared to the tobacco e-liquid and more frequently in larger groups (>10 puffs) with their usual brand. The strength of the relationship between vaping topography and nicotine intake and exposure were not consistent across e-liquids. Vaping behavior changes across e-liquids and influences nicotine intake. Research is needed to understand the mechanisms that underlie these behavioral changes, including e-liquid pH and related sensory effects, subjective liking, and nicotine effects. Copyright © 2018. Published by Elsevier B.V.

LiDAR point classification based on sparse representation

NASA Astrophysics Data System (ADS)

Li, Nan; Pfeifer, Norbert; Liu, Chun

2017-04-01

In order to combine the initial spatial structure and features of LiDAR data for accurate classification. The LiDAR data is represented as a 4-order tensor. Sparse representation for classification(SRC) method is used for LiDAR tensor classification. It turns out SRC need only a few of training samples from each class, meanwhile can achieve good classification result. Multiple features are extracted from raw LiDAR points to generate a high-dimensional vector at each point. Then the LiDAR tensor is built by the spatial distribution and feature vectors of the point neighborhood. The entries of LiDAR tensor are accessed via four indexes. Each index is called mode: three spatial modes in direction X ,Y ,Z and one feature mode. Sparse representation for classification(SRC) method is proposed in this paper. The sparsity algorithm is to find the best represent the test sample by sparse linear combination of training samples from a dictionary. To explore the sparsity of LiDAR tensor, the tucker decomposition is used. It decomposes a tensor into a core tensor multiplied by a matrix along each mode. Those matrices could be considered as the principal components in each mode. The entries of core tensor show the level of interaction between the different components. Therefore, the LiDAR tensor can be approximately represented by a sparse tensor multiplied by a matrix selected from a dictionary along each mode. The matrices decomposed from training samples are arranged as initial elements in the dictionary. By dictionary learning, a reconstructive and discriminative structure dictionary along each mode is built. The overall structure dictionary composes of class-specified sub-dictionaries. Then the sparse core tensor is calculated by tensor OMP(Orthogonal Matching Pursuit) method based on dictionaries along each mode. It is expected that original tensor should be well recovered by sub-dictionary associated with relevant class, while entries in the sparse tensor associated with

Limit on the production of a low-mass vector boson in e+e- → Uγ, U →e+e- with the KLOE experiment

NASA Astrophysics Data System (ADS)

Anastasi, A.; Babusci, D.; Bencivenni, G.; Berlowski, M.; Bloise, C.; Bossi, F.; Branchini, P.; Budano, A.; Caldeira Balkeståhl, L.; Cao, B.; Ceradini, F.; Ciambrone, P.; Curciarello, F.; Czerwiński, E.; D'Agostini, G.; Danè, E.; De Leo, V.; De Lucia, E.; De Santis, A.; De Simone, P.; Di Cicco, A.; Di Domenico, A.; Di Salvo, R.; Domenici, D.; D'Uffizi, A.; Fantini, A.; Felici, G.; Fiore, S.; Gajos, A.; Gauzzi, P.; Giardina, G.; Giovannella, S.; Graziani, E.; Happacher, F.; Heijkenskjöld, L.; Ikegami Andersson, W.; Johansson, T.; Kamińska, D.; Krzemien, W.; Kupsc, A.; Loffredo, S.; Mandaglio, G.; Martini, M.; Mascolo, M.; Messi, R.; Miscetti, S.; Morello, G.; Moricciani, D.; Moskal, P.; Palladino, A.; Papenbrock, M.; Passeri, A.; Patera, V.; Perez del Rio, E.; Ranieri, A.; Santangelo, P.; Sarra, I.; Schioppa, M.; Silarski, M.; Sirghi, F.; Tortora, L.; Venanzoni, G.; Wiślicki, W.; Wolke, M.

2015-11-01

The existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the light vector mediator of this dark force, the U boson, with the KLOE detector at the DAΦNE e+e- collider. Using an integrated luminosity of 1.54 fb-1, we studied the process e+e- → Uγ, with U →e+e-, using radiative return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90% CL upper limit on the mixing strength between the Standard Model photon and the dark photon, ɛ2, at 10-6-10-4 in the 5- 520 MeV /c2 mass range.

Reliability of the ADI-R: Multiple Examiners Evaluate a Single Case

ERIC Educational Resources Information Center

Cicchetti, Domenic V.; Lord, Catherine; Koenig, Kathy; Klin, Ami; Volkmar, Fred R.

2008-01-01

The authors assessed the reliability of the Autism Diagnostic Interview (ADI-R). Seven Clinical Examiners evaluated a three and one half year old female toddler suspected of being on the Autism Spectrum. Examiners showed agreement levels of 94-96% across all items, with weighted kappa (K[subscript w]) between 0.80 and 0.88. They were in 100%…

Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid.

PubMed

Zhang, Mingming; Zhang, Keyu; Mehmood, Muhammad Aamer; Zhao, Zongbao Kent; Bai, Fengwu; Zhao, Xinqing

2017-12-01

The aim of this work was to study the effects of deleting acetate transporter gene ADY2 on growth and fermentation of Saccharomyces cerevisiae in the presence of inhibitors. Comparative transcriptome analysis revealed that three genes encoding plasma membrane carboxylic acid transporters, especially ADY2, were significantly downregulated under the zinc sulfate addition condition in the presence of acetic acid stress, and the deletion of ADY2 improved growth of S. cerevisiae under acetic acid, ethanol and hydrogen peroxide stresses. Consistently, a concomitant increase in ethanol production by 14.7% in the presence of 3.6g/L acetic acid was observed in the ADY2 deletion mutant of S. cerevisiae BY4741. Decreased intracellular acetic acid, ROS accumulation, and plasma membrane permeability were observed in the ADY2 deletion mutant. These findings would be useful for developing robust yeast strains for efficient ethanol production. Copyright © 2017 Elsevier Ltd. All rights reserved.

Nonclassical MHC-E (Mamu-E) expression in the rhesus monkey placenta

PubMed Central

Dambaeva, Svetlana V.; Bondarenko, Gennadiy I.; Grendell, Richard L.; Kravitz, Rachel H.; Durning, Maureen; Golos, Thaddeus G.

2009-01-01

The aim of this study was to characterize the expression of the rhesus HLA-E ortholog Mamu-E, particularly at the maternal-fetal interface. Mamu-E expression was confirmed by locus-specific RT-PCR in the placenta as well as in peripheral blood mononuclear cells (PBMC) and other organs. We evaluated the utility of antibodies recognizing HLA-E (MEM-E/06 against native HLA-E, MEM-E/02 against denatured HLA-E) to detect Mamu-E by flow cytometry/immunofluorescence, Western blot, and immunohistochemistry (IHC). Western blot analysis of cells and selected transfectants confirmed the recognition of Mamu-E but not Mamu-AG by antibodies MEM-E/06 and HC10 but not MEM-E/02. Immunohistochemical staining of frozen sections of rhesus placenta with the MEM-E/06 antibody demonstrated expression in most populations of rhesus monkey trophoblast cells, including villous cytotrophoblasts (strong positive staining), apical membrane of syncytiotrophoblasts (light to moderate staining) and extravillous cytotrophoblasts (moderate to strong staining, especially endovascular trophoblasts in early pregnancy). Expression was not trophoblast cell-specific, especially at term, when endothelial cells in both the chorionic plate and placental villi showed strong staining for Mamu-E. Staining of rhesus extravillous trophoblast cells suggested the co-expression of Mamu-E and Mamu-AG (the rhesus HLA-G homolog) on these cells. MEM-E/06 was shown also to react with differentiating rhesus placental syncytiotrophoblasts in primary culture, detecting intracellular and weak surface expression of Mamu-E. We conclude that the gestation-dependent co-expression of Mamu-E with Mamu-AG in villous and extravillous trophoblast cells suggests important and perhaps complementary but distinct roles of these two nonclassical MHC class I loci in pregnancy at the maternal-fetal interface. In addition, the MEM-E/06 antibody will be useful for the detection of Mamu-E at the maternal-fetal interface in the rhesus monkey

Study on environmental test technology of LiDAR used for vehicle

NASA Astrophysics Data System (ADS)

Wang, Yi; Yang, Jianfeng; Ou, Yong

2018-03-01

With the development of intelligent driving, the LiDAR used for vehicle plays an important role in it, in some extent LiDAR is the key factor of intelligent driving. And environmental adaptability is one critical factor of quality, it relates success or failure of LiDAR. This article discusses about the environment and its effects on LiDAR used for vehicle, it includes analysis of any possible environment that vehicle experiences, and environmental test design.

Forest structures retrieval from LiDAR onboard ULA

NASA Astrophysics Data System (ADS)

Shang, Xiaoxia; Chazette, Patrick; Totems, Julien; Marnas, Fabien; Sanak, Joseph

2013-04-01

Following the United Nations Framework Convention on Climate Change, the assessment of forest carbon stock is one of the main elements for a better understanding of the carbon cycle and its evolution following the climate change. The forests sequester 80% of the continental biospheric carbon and this efficiency is a function of the tree species and the tree health. The airborne backscatter LiDAR onboard the ultra light aircraft (ULA) can provide the key information on the forest vertical structures and evolution in the time. The most important structural parameter is the tree top height, which is directly linked to the above-ground biomass using non-linear relationships. In order to test the LiDAR capability for retrieving the tree top height, the LiDAR ULICE (Ultraviolet LIdar for Canopy Experiment) has been used over different forest types, from coniferous (maritime pins) to deciduous (oaks, hornbeams ...) trees. ULICE works at the wavelength of 355 nm with a sampling along the line-of-sight between 15 and 75 cm. According to the LiDAR signal to noise ratio (SNR), two different algorithms have been used in our study. The first algorithm is a threshold method directly based on the comparison between the LiDAR signal and the noise distributions, while the second one used a low pass filter by fitting a Gaussian curve family. In this paper, we will present these two algorithms and their evolution as a function of the SNR. The main error sources will be also discussed and assessed for each algorithm. The results show that these algorithms have great potential for ground-segment of future space borne LiDAR missions dedicated to the forest survey at the global scale. Acknowledgements: the canopy LiDAR system ULICE has been developed by CEA (Commissariat à l'Energie Atomique). It has been deployed with the support of CNES (Centre National d'Etude Spariales) and ANR (Agence Nationale de la Recherche). We acknowledge the ULA pilots Franck Toussaint for logistical help

Validating LiDAR Derived Estimates of Canopy Height, Structure and Fractional Cover in Riparian Areas: A Comparison of Leaf-on and Leaf-off LiDAR Data

NASA Astrophysics Data System (ADS)

Wasser, L. A.; Chasmer, L. E.; Taylor, A.; Day, R.

2010-12-01

Characterization of riparian buffers is integral to understanding the landscape scale impacts of disturbance on wildlife and aquatic ecosystems. Riparian buffers may be characterized using in situ plot sampling or via high resolution remote sensing. Field measurements are time-consuming and may not cover a broad range of ecosystem types. Further, spectral remote sensing methods introduce a compromise between spatial resolution (grain) and area extent. Airborne LiDAR can be used to continuously map and characterize riparian vegetation structure and composition due to the three-dimensional reflectance of laser pulses within and below the canopy, understory and at the ground surface. The distance between reflections (or ‘returns’) allows for detection of narrow buffer corridors at the landscape scale. There is a need to compare leaf-off and leaf-on surveyed LiDAR data with in situ measurements to assess accuracy in landscape scale analysis. These comparisons are particularly important considering increased availability of leaf-off surveyed LiDAR datasets. And given this increased availability, differences between leaf-on and leaf-off derived LiDAR metrics are largely unknown for riparian vegetation of varying composition and structure. This study compares the effectiveness of leaf-on and leaf-off LiDAR in characterizing riparian buffers of varying structure and composition as compared to field measurements. Field measurements were used to validate LiDAR derived metrics. Vegetation height, canopy cover, density and overstory and understory species composition were recorded in 80 random plots of varying vegetation type, density and structure within a Pennsylvania watershed (-77.841, 40.818). Plot data were compared with LiDAR data collected during leaf on and leaf off conditions to determine 1) accuracy of LiDAR derived metrics compared to field measures and 2) differences between leaf-on and leaf-off LiDAR metrics. Results illustrate that differences exist between

The Theory of Planned Behavior and E-cig Use: Impulsive Personality, E-cig Attitudes, and E-cig Use.

PubMed

Hershberger, Alexandra; Connors, Miranda; Um, Miji; Cyders, Melissa A

2018-04-01

The current paper applied the Theory of Planned Behavior (TPB; Ajzen & Fishbein, 1988) to understand how impulsive personality traits and attitudes concerning e-cig use relate to the likelihood of electronic cigarette (e-cig) use. Seven hundred and fourteen participants (Mean age = 34.04, SD = 10.89, 48.6% female) completed cross-sectional measures of e-cig use attitudes (CEAC) and the Short UPPS-P Impulsive Behavior Scale. A structural path analysis suggested that urgency and deficits in conscientiousness were significantly related to e-cig attitudes (CFI = 0.99, TLI = 0.99, RMSEA = 0.02; urgency: β = 0.32, p = .001; deficits in conscientiousness: β = -0.48, p < .001). E-cig attitude scores were significantly higher for e-cig users than non-users, β = 0.85, p < .001. There was no significant direct path from impulsive personality traits to e-cig use. Findings provide initial support for a model in which impulsive traits are related to e-cig use through positive e-cig attitudes.

Cascades from nu_E above 1020 eV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, Spencer R.

2004-12-21

At very high energies, the Landau-Pomeranchuk-Migdal effect reduces the cross sections for electron bremsstrahlung and photon e{sup +}e{sup -} pair production. The fractional electron energy loss and pair production cross sections drop as the energy increases. In contrast, the cross sections for photonuclear interactions grow with energy. In solids and liquids, at energies above 10{sup 20} eV, photonuclear reactions dominate, and showers that originate as photons or electrons quickly become hadronic showers. These electron-initiated hadronic showers are much shorter (due to the absence of the LPM effect), but wider than purely electromagnetic showers would be. This change in shape altersmore » the spectrum of the electromagnetic and acoustic radiation emitted from the shower. These alterations have important implications for existing and planned searches for radiation from u{sub e} induced showers above 10{sup 20} eV, and some existing limits should be reevaluated.« less

A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes

NASA Astrophysics Data System (ADS)

Lu, Xiaolong; Malley, Konstantin R.; Brenner, Caitlin C.; Koroleva, Olga; Korolev, Sergey; Downes, Brian P.

2016-08-01

Ubiquitin (Ub) is a protein modifier that controls processes ranging from protein degradation to endocytosis, but early-acting regulators of the three-enzyme ubiquitylation cascade are unknown. Here we report that the prenylated membrane-anchored ubiquitin-fold protein (MUB) is an early-acting regulator of subfamily-specific E2 activation. An AtMUB3:AtUBC8 co-crystal structure defines how MUBs inhibit E2~Ub formation using a combination of E2 backside binding and a MUB-unique lap-bar loop to block E1 access. Since MUBs tether Arabidopsis group VI E2 enzymes (related to HsUbe2D and ScUbc4/5) to the plasma membrane, and inhibit E2 activation at physiological concentrations, they should function as potent plasma membrane localized regulators of Ub chain synthesis in eukaryotes. Our findings define a biochemical function for MUB, a family of highly conserved Ub-fold proteins, and provide an example of selective activation between cognate Ub E2s, previously thought to be constitutively activated by E1s.

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

DOE PAGES

Sekiyama, Naotaka; Arthanari, Haribabu; Papadopoulos, Evangelos; ...

2015-07-13

The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events stimulate serial phosphorylation of 4E-BP, primarily by mammalian target of rapamycin complex 1 (mTORC1) at residues T 37/T 46, followed by T 70 and S 65. Hyperphosphorylated 4E-BP dissociates from eIF4E, allowing eIF4E to interact with eIF4G and translation initiation to resume. Because overexpression of eIF4E is linked to cellular transformation, 4E-BP is a tumor suppressor, and up-regulation of its activity is amore » goal of interest for cancer therapy. A recently discovered small molecule, eIF4E/eIF4G interaction inhibitor 1 (4EGI-1), disrupts the eIF4E/eIF4G interaction and promotes binding of 4E-BP1 to eIF4E. Structures of 14- to 16-residue 4E-BP fragments bound to eIF4E contain the eIF4E consensus binding motif, 54YXXXXLΦ 60 (motif 1) but lack known phosphorylation sites. We report in this paper a 2.1-Å crystal structure of mouse eIF4E in complex with m 7GTP and with a fragment of human 4E-BP1, extended C-terminally from the consensus-binding motif (4E-BP1 50–84). The extension, which includes a proline-turn-helix segment (motif 2) followed by a loop of irregular structure, reveals the location of two phosphorylation sites (S 65 and T 70). Our major finding is that the C-terminal extension (motif 3) is critical to 4E-BP1–mediated cell cycle arrest and that it partially overlaps with the binding site of 4EGI-1. Finally, the binding of 4E-BP1 and 4EGI-1 to eIF4E is therefore not mutually exclusive, and both ligands contribute to shift the equilibrium toward the inhibition of translation initiation.« less

Modelling rating curves using remotely sensed LiDAR data

USGS Publications Warehouse

Nathanson, Marcus; Kean, Jason W.; Grabs, Thomas J.; Seibert, Jan; Laudon, Hjalmar; Lyon, Steve W.

2012-01-01

Accurate stream discharge measurements are important for many hydrological studies. In remote locations, however, it is often difficult to obtain stream flow information because of the difficulty in making the discharge measurements necessary to define stage-discharge relationships (rating curves). This study investigates the feasibility of defining rating curves by using a fluid mechanics-based model constrained with topographic data from an airborne LiDAR scanning. The study was carried out for an 8m-wide channel in the boreal landscape of northern Sweden. LiDAR data were used to define channel geometry above a low flow water surface along the 90-m surveyed reach. The channel topography below the water surface was estimated using the simple assumption of a flat streambed. The roughness for the modelled reach was back calculated from a single measurment of discharge. The topographic and roughness information was then used to model a rating curve. To isolate the potential influence of the flat bed assumption, a 'hybrid model' rating curve was developed on the basis of data combined from the LiDAR scan and a detailed ground survey. Whereas this hybrid model rating curve was in agreement with the direct measurements of discharge, the LiDAR model rating curve was equally in agreement with the medium and high flow measurements based on confidence intervals calculated from the direct measurements. The discrepancy between the LiDAR model rating curve and the low flow measurements was likely due to reduced roughness associated with unresolved submerged bed topography. Scanning during periods of low flow can help minimize this deficiency. These results suggest that combined ground surveys and LiDAR scans or multifrequency LiDAR scans that see 'below' the water surface (bathymetric LiDAR) could be useful in generating data needed to run such a fluid mechanics-based model. This opens a realm of possibility to remotely sense and monitor stream flows in channels in remote

Resonant slepton production yields CMS e e j j and e p Tj j excesses

NASA Astrophysics Data System (ADS)

Allanach, Ben; Biswas, Sanjoy; Mondal, Subhadeep; Mitra, Manimala

2015-01-01

Recent CMS searches for dileptoquark production report local excesses of 2.4 σ in an e e j j channel and 2.6 σ in an e p Tj j channel. Here, we simultaneously explain both excesses with resonant slepton production in R -parity violating supersymmetry. We consider resonant slepton production, which decays to a lepton and a chargino/neutralino, followed by three-body decays of the neutralino/chargino via an R -parity violating coupling. There are regions of parameter space which are also compatible at the 95% confidence level with a 2.8 σ e e j j excess in a recent CMS WR search, while being compatible with other direct search constraints. Phase II of the GERDA neutrinoless double beta decay (0 ν β β ) experiment will probe a sizable portion of the good-fit region.

(e,2e) and (Î3,2e) Processes: Open and Closed Questions

NASA Astrophysics Data System (ADS)

An important breakthrough has been achieved recently in the description of (e,2e) and (Î3,2e) processes with the development of new ab-initio theories: the external complex scaling theory (ECS), the time dependent close coupling theory (TDCC), and the hyperspherical R-matrix theory with semiclassical outgoing waves (HRM-SOW). The principles of these various theories are summarized, their relations are considered, and their achievements are discussed with respect to the available experimental data regarding electron impact ionization of H and photo double ionization of He. Possible directions for future work are outlined.

Receptivity to e-cigarette marketing, harm perceptions, and e-cigarette use.

PubMed

Pokhrel, Pallav; Fagan, Pebbles; Kehl, Lisa; Herzog, Thaddeus A

2015-01-01

To test whether exposure and receptivity to e-cigarette marketing are associated with recent e-cigarette use among young adults through increased beliefs that e-cigarettes are less harmful than cigarettes. Data were collected from 307 multiethnic 4- and 2-year college students; approximately equal proportions of current, never, and former cigarette smokers [mean age = 23.5 (SD = 5.5); 65% female]. Higher receptivity to e-cigarette marketing was associated with perceptions that e-cigarettes are less harmful than cigarettes, which in turn, were associated with higher recent e-cigarette use. The findings provide preliminary support to the proposition that marketing of e-cigarettes as safer alternatives to cigarettes or cessation aids is associated with increased e-cigarette use among young adults. The findings have implications for development of e-cigarette regulations.

Mapping SOC (Soil Organic Carbon) using LiDAR-derived vegetation indices in a random forest regression model

NASA Astrophysics Data System (ADS)

Will, R. M.; Glenn, N. F.; Benner, S. G.; Pierce, J. L.; Spaete, L.; Li, A.

2015-12-01

Quantifying SOC (Soil Organic Carbon) storage in complex terrain is challenging due to high spatial variability. Generally, the challenge is met by transforming point data to the entire landscape using surrogate, spatially-distributed, variables like elevation or precipitation. In many ecosystems, remotely sensed information on above-ground vegetation (e.g. NDVI) is a good predictor of below-ground carbon stocks. In this project, we are attempting to improve this predictive method by incorporating LiDAR-derived vegetation indices. LiDAR provides a mechanism for improved characterization of aboveground vegetation by providing structural parameters such as vegetation height and biomass. In this study, a random forest model is used to predict SOC using a suite of LiDAR-derived vegetation indices as predictor variables. The Reynolds Creek Experimental Watershed (RCEW) is an ideal location for a study of this type since it encompasses a strong elevation/precipitation gradient that supports lower biomass sagebrush ecosystems at low elevations and forests with more biomass at higher elevations. Sagebrush ecosystems composed of Wyoming, Low and Mountain Sagebrush have SOC values ranging from .4 to 1% (top 30 cm), while higher biomass ecosystems composed of aspen, juniper and fir have SOC values approaching 4% (top 30 cm). Large differences in SOC have been observed between canopy and interspace locations and high resolution vegetation information is likely to explain plot scale variability in SOC. Mapping of the SOC reservoir will help identify underlying controls on SOC distribution and provide insight into which processes are most important in determining SOC in semi-arid mountainous regions. In addition, airborne LiDAR has the potential to characterize vegetation communities at a high resolution and could be a tool for improving estimates of SOC at larger scales.

E-Books and E-Book Apps: Considerations for Beginning Readers

ERIC Educational Resources Information Center

Bates, Celeste C.; Klein, Adria; Schubert, Barbara; McGee, Lea; Anderson, Nancy; Dorn, Linda; McClure, Erin; Ross, Rachael Huber

2017-01-01

This article highlights considerations for teachers when selecting and using e-books and e-book applications (apps) with beginning readers during guided and independent reading. A framework for examining e-books and e-book apps is suggested, and several apps and related digital features are described. The article also includes an overview of…

Global application of disorders of sex development-related electronic resources: e-learning, e-consultation and e-information sharing.

PubMed

Muscarella, Miriam; Kranenburg-van Koppen, Laura; Grijpink-van den Biggelaar, Kalinka; Drop, Stenvert L S

2014-01-01

The past 20 years have seen proliferation of electronic (e) resources that promote improved understanding of disorders of sex development (DSD): e-learning for physicians and trainees, e-consultation between clinicians, and e-information for families and affected individuals. Recent e-learning advances have emerged from the European Society for Pediatric Endocrinology's online learning portal for current physicians and trainees. Developed with attention to developing clinical competencies incorporating learning theory, and presenting material that represents international best practice, this e-learning portal offers advances in training, making information more accessible for clinicians and trainees. Multiple levels of instruction, authentic case examples, collaborative forums for physicians and trainees, individualized feedback and user-friendly tools represent advances in trainee and physician learning that can take place in any location. e-consultation is an emerging tool that aims to connect physicians with specialists experienced in DSD care. Although it faces logistical challenges, e-consultation carries the potential to improve DSD care, especially in remote areas with limited access to DSD specialists. e-information for families and patients of all ages is widely accessible online, often with focus on DSD biology, medical care, and psychological and social support. e-information tools aid self-management and support of those affected by DSD. Efforts to improve these resources should aim to map information to individual users, incorporate optimally clear nomenclature, and continue as a 'shared enterprise' of clinicians, affected individuals, families and researchers. Improving the quality of DSD-related e-learning and e-information and developing e-consultation carries the potential to transform DSD care and support for patients, families and physicians worldwide. © 2014 S. Karger AG, Basel.

26 CFR 1.367(e)-0 - Outline of §§ 1.367(e)-1 and 1.367(e)-2.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Outline of §§ 1.367(e)-1 and 1.367(e)-2. 1.367(e)-0 Section 1.367(e)-0 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Effects on Corporation § 1.367(e)-0 Outline of §§ 1.367(e)-1...

Quantifying Wave Breaking Shape and Type in the Surf-Zone Using LiDAR

NASA Astrophysics Data System (ADS)

Albright, A.; Brodie, K. L.; Hartzell, P. J.; Glennie, C. L.

2017-12-01

Waves change shape as they shoal and break across the surf-zone, ultimately dissipating and transferring their energy into turbulence by either spilling or plunging. This injection of turbulence and changes in wave shape can affect the direction of sediment transport at the seafloor, and ultimately lead to morphological evolution. Typical methods for collecting wave data in the surf-zone include in-situ pressure gauges, velocimeters, ultrasonic sensors, and video imagery. Drawbacks to these data collection methods are low spatial resolution of point measurements, reliance on linear theory to calculate sea-surface elevations, and intensive computations required to extract wave properties from stereo 2D imagery. As a result, few field measurements of the shapes of plunging and/or spilling breakers exist, and existing knowledge is confined to results of laboratory studies. We therefore examine the use of a multi-beam scanning Light Detection and Ranging (LiDAR) remote sensing instrument with the goal of classifying the breaking type of propagating waves in the surf-zone and quantitatively determining wave morphometric properties. Data were collected with a Velodyne HDL-32E LiDAR scanner (360° vertical field of view) mounted on an arm of the Coastal Research Amphibious Buggy (CRAB) at the U.S. Army Corps of Engineers Field Research Facility in Duck, North Carolina. Processed laser scan data are used to visualize the lifecycle of a wave (shoaling, breaking, broken) and identify wave types (spilling, plunging, non-breaking) as they pass beneath the scanner. For each rotation of the LiDAR scanner, the point cloud data are filtered, smoothed, and detrended in order to identify individual waves and measure their properties, such as speed, height, period, upward/downward slope, asymmetry, and skewness. The 3D nature of point cloud data is advantageous for research, because it enables viewing from any angle. In our analysis, plan views are used to separate individual waves

Receptivity to E-cigarette Marketing, Harm Perceptions, and E-cigarette Use

PubMed Central

Pokhrel, Pallav; Fagan, Pebbles; Kehl, Lisa; Herzog, Thaddeus A.

2016-01-01

Objective To test whether exposure and receptivity to e-cigarette marketing are associated with recent e-cigarette use among young adults through increased beliefs that e-cigarettes are less harmful than cigarettes. Methods Data were collected from 307 multiethnic 4- and 2-year college students; approximately equal proportions of current, never, and former cigarette smokers [mean age = 23.5 (SD = 5.5); 65% female]. Results Higher receptivity to e-cigarette marketing was associated with perceptions that e-cigarettes are less harmful than cigarettes, which in turn, were associated with higher recent e-cigarette use. Conclusions The findings provide preliminary support to the proposition that marketing of e-cigarettes as safer alternatives to cigarettes or cessation aids is associated with increased e-cigarette use among young adults. The findings have implications for development of e-cigarette regulations. PMID:25290604

eTeacher: Providing Personalized Assistance to E-Learning Students

ERIC Educational Resources Information Center

Schiaffino, Silvia; Garcia, Patricio; Amandi, Analia

2008-01-01

In this paper we present eTeacher, an intelligent agent that provides personalized assistance to e-learning students. eTeacher observes a student's behavior while he/she is taking online courses and automatically builds the student's profile. This profile comprises the student's learning style and information about the student's performance, such…

DArT Markers Effectively Target Gene Space in the Rye Genome.

PubMed

Gawroński, Piotr; Pawełkowicz, Magdalena; Tofil, Katarzyna; Uszyński, Grzegorz; Sharifova, Saida; Ahluwalia, Shivaksh; Tyrka, Mirosław; Wędzony, Maria; Kilian, Andrzej; Bolibok-Brągoszewska, Hanna

2016-01-01

Large genome size and complexity hamper considerably the genomics research in relevant species. Rye ( Secale cereale L.) has one of the largest genomes among cereal crops and repetitive sequences account for over 90% of its length. Diversity Arrays Technology is a high-throughput genotyping method, in which a preferential sampling of gene-rich regions is achieved through the use of methylation sensitive restriction enzymes. We obtained sequences of 6,177 rye DArT markers and following a redundancy analysis assembled them into 3,737 non-redundant sequences, which were then used in homology searches against five Pooideae sequence sets. In total 515 DArT sequences could be incorporated into publicly available rye genome zippers providing a starting point for the integration of DArT- and transcript-based genomics resources in rye. Using Blast2Go pipeline we attributed putative gene functions to 1101 (29.4%) of the non-redundant DArT marker sequences, including 132 sequences with putative disease resistance-related functions, which were found to be preferentially located in the 4RL and 6RL chromosomes. Comparative analysis based on the DArT sequences revealed obvious inconsistencies between two recently published high density consensus maps of rye. Furthermore we demonstrated that DArT marker sequences can be a source of SSR polymorphisms. Obtained data demonstrate that DArT markers effectively target gene space in the large, complex, and repetitive rye genome. Through the annotation of putative gene functions and the alignment of DArT sequences relative to reference genomes we obtained information, that will complement the results of the studies, where DArT genotyping was deployed, by simplifying the gene ontology and microcolinearity based identification of candidate genes.

Exploring the e-cigarette e-commerce marketplace: Identifying Internet e-cigarette marketing characteristics and regulatory gaps.

PubMed

Mackey, Tim K; Miner, Angela; Cuomo, Raphael E

2015-11-01

The electronic cigarette (e-cigarette) market is maturing into a billion-dollar industry. Expansion includes new channels of access not sufficiently assessed, including Internet sales of e-cigarettes. This study identifies unique e-cigarette Internet vendor characteristics, including geographic location, promotional strategies, use of social networking, presence/absence of age verification, and consumer warning representation. We performed structured Internet search engine queries and used inclusion/exclusion criteria to identify e-cigarette vendors. We then conducted content analysis of characteristics of interest. Our examination yielded 57 e-cigarette Internet vendors including 54.4% (n=31) that sold exclusively online. The vast majority of websites (96.5%, n=55) were located in the U.S. Vendors used a variety of sales promotion strategies to market e-cigarettes including 70.2% (n=40) that used more than one social network service (SNS) and 42.1% (n=24) that used more than one promotional sales strategies. Most vendors (68.4%, n=39) displayed one or more health warnings on their website, but often displayed them in smaller font or in their terms and conditions. Additionally, 35.1% (n=20) of vendors did not have any detectable age verification process. E-cigarette Internet vendors are actively engaged in various promotional activities to increase the appeal and presence of their products online. In the absence of FDA regulations specific to the Internet, the e-cigarette e-commerce marketplace is likely to grow. This digital environment poses unique challenges requiring targeted policy-making including robust online age verification, monitoring of SNS marketing, and greater scrutiny of certain forms of marketing promotional practices. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Religiosidade, juventude e sexualidade: entre a autonomia e a rigidez1

PubMed Central

Silva, Cristiane Gonçalves da; Santos, Alessandro Oliveira; Licciardi, Daniele Carli; Paiva, Vera; Parker, Richard

2009-01-01

Esse artigo descreve como jovens religiosos e autoridades religiosas de sua comunidade compreendem a sexualidade, considerando suas experiências pessoais e como membros de comunidades religiosas. A análise pretende contribuir para que políticas públicas dedicadas à promoção da saúde sexual da juventude considerem a religiosidade, no contexto de um estado laico e da promoção do direito à prevenção. Foram realizadas 26 entrevistas abertas e semidirigidas em diferentes comunidades da região metropolitana da cidade de São Paulo (comunidades católicas, da umbanda, do candomblé e de diferentes denominações evangélicas) sobre iniciação sexual, casamento, gravidez, contracepção e prevenção das DST/Aids, homossexualidade, aborto e direitos humanos. Observou-se como jovens e autoridades religiosas convivem com a tensão entre tradição e modernidade e os distintos discursos sobre a sexualidade. Como sujeitos religiosos (do discurso religioso) e sujeitos sexuais (de discursos sobre sexualidade), devem ser incorporados pelos programas como sujeitos de direito nos termos de sua religiosidade. PMID:21886456

Healthy e-health? Think 'environmental e-health'!

PubMed

Scott, Richard E; Saunders, Chad; Palacios, Moné; Nguyen, Duyen Thi Kim; Ali, Sajid

2010-01-01

The Environmental e-Health Research and Training Program has completed its scoping study to understand the breadth of a new field of research: Environmental e-Health. Nearly every aspect of modern life is associated, directly or indirectly, with application of technology, from a cup of coffee, through transportation to and from work, to appliances in the home and industrial activities. In recent decades the rapidly increasing application of information and communications technologies (ICT) has added to the cacophony of technological 'noise' around us. Research has shown that technology use, including ICTs, has impact upon the environment. Studying environmental impact in such a complex global setting is daunting. e-Health is now being used as a convenient microcosm of ICT application within which to study these impacts, and is particularly poignant given that e-Health's environmental harms conflict with its noble goals of 'doing no harm'. The study has identified impacts, both benefits and harms in all three life-cycle phases for e-Health: up-stream (materials extraction, manufacturing, packaging, distribution), mid-stream (use period), and down-stream (end-of-life processes--disposal, recycling). In addition the literature shows that a holistic 'Life Cycle Assessment' approach is essential to understand the complexity of the setting, and determine the true balance between total harms and total benefits, and for whom.

(E,E)-alpha-farnesene, an alarm pheromone of the termite Prorhinotermes canalifrons.

PubMed

Sobotník, Jan; Hanus, Robert; Kalinová, Blanka; Piskorski, Rafal; Cvacka, Josef; Bourguignon, Thomas; Roisin, Yves

2008-04-01

The behavioral and electroantennographic responses of Prorhinotermes canalifrons to its soldier frontal gland secretion, and two separated major components of the secretion, (E)-1-nitropentadec-1-ene and (E,E)-alpha-farnesene, were studied in laboratory experiments. Behavioral experiments showed that both the frontal gland secretion and (E,E)-alpha-farnesene triggered alarm reactions in P. canalifrons, whereas (E)-1-nitropentadec-1-ene did not affect the behavior of termite groups. The alarm reactions were characterized by rapid walking of activated termites and efforts to alert and activate other members of the group. Behavioral responses to alarm pheromone differed between homogeneous and mixed groups, suggesting complex interactions. Antennae of both soldiers and pseudergates were sensitive to the frontal gland secretion and to (E,E)-alpha-farnesene, but soldiers showed stronger responses. The dose responses to (E,E)-alpha-farnesene were identical for both soldiers and pseudergates, suggesting that both castes use similar receptors to perceive (E,E)-alpha-farnesene. Our data confirm (E,E)-alpha-farnesene as an alarm pheromone of P. canalifrons.

Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis.

PubMed

Forbes, Scott P; Alferiev, Ivan S; Chorny, Michael; Adamo, Richard F; Levy, Robert J; Fishbein, Ilia

2013-09-01

Gene therapy with viral vectors encoding for NOS enzymes has been recognized as a potential therapeutic approach for the prevention of restenosis. Optimal activity of iNOS is dependent on the intracellular availability of L-Arg and BH4 via prevention of NOS decoupling and subsequent ROS formation. Herein, we investigated the effects of separate and combined L-Arg and BH4 supplementation on the production of NO and ROS in cultured rat arterial smooth muscle and endothelial cells transduced with AdiNOS, and their impact on the antirestenotic effectiveness of AdiNOS delivery to balloon-injured rat carotid arteries. Supplementation of AdiNOS transduced endothelial and vascular smooth muscle cells with L-Arg (3.0 mM), BH4 (10 μM) and especially their combination resulted in a significant increase in NO production as measured by nitrite formation in media. Formation of ROS was dose-dependently increased following transduction with increasing MOIs of AdiNOS. Exposure of RASMC to AdiNOS tethered to meshes via a hydrolyzable cross-linker, modeling viral delivery from stents, resulted in increased ROS production, which was decreased by supplementation with BH4 but not L-Arg or L-Arg/BH4. Enhanced cell death, caused by AdiNOS transduction, was also preventable with BH4 supplementation. In the rat carotid model of balloon injury, intraluminal delivery of AdiNOS in BH4-, L-Arg-, and especially in BH4 and L-Arg supplemented animals was found to significantly enhance the antirestenotic effects of AdiNOS-mediated gene therapy. Fine-tuning of iNOS function by L-Arg and BH4 supplementation in the transduced vasculature augments the therapeutic potential of gene therapy with iNOS for the prevention of restenosis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis

PubMed Central

Forbes, Scott P.; Alferiev, Ivan S.; Chorny, Michael; Adamo, Richard F.; Levy, Robert J.; Fishbein, Ilia

2013-01-01

Objective Gene therapy with viral vectors encoding for NOS enzymes has been recognized as a potential therapeutic approach for the prevention of restenosis. Optimal activity of iNOS is dependent on the intracellular availability of L-Arg and BH4 via prevention of NOS decoupling and subsequent ROS formation. Herein, we investigated the effects of separate and combined L-Arg and BH4 supplementation on the production of NO and ROS in cultured rat arterial smooth muscle and endothelial cells transduced with AdiNOS, and their impact on the antirestenotic effectiveness of AdiNOS delivery to balloon-injured rat carotid arteries. Methods and Results Supplementation of AdiNOS transduced endothelial and vascular smooth muscle cells with L-Arg (3.0 mM), BH4 (10 μM) and especially their combination resulted in a significant increase in NO production as measured by nitrite formation in media. Formation of ROS was dose-dependently increased following transduction with increasing MOIs of AdiNOS. Exposure of RASMC to AdiNOS tethered to meshes via a hydrolysable cross-linker, modeling viral delivery from stents, resulted in increased ROS production, which was decreased by supplementation with BH4 but not L-Arg or L-Arg/BH4. Enhanced cell death, caused by AdiNOS transduction, was also preventable with BH4 supplementation. In the rat carotid model of balloon injury, intraluminal delivery of AdiNOS in BH4-, L-Arg-, and especially in BH4 and L-Arg supplemented animals was found to significantly enhance the antirestenotic effects of AdiNOS-mediated gene therapy. Conclusions Fine-tuning of iNOS function by L-Arg and BH4 supplementation in the transduced vasculature augments the therapeutic potential of gene therapy with iNOS for the prevention of restenosis. PMID:23958248

Detecting understory plant invasion in urban forests using LiDAR

NASA Astrophysics Data System (ADS)

Singh, Kunwar K.; Davis, Amy J.; Meentemeyer, Ross K.

2015-06-01

Light detection and ranging (LiDAR) data are increasingly used to measure structural characteristics of urban forests but are rarely used to detect the growing problem of exotic understory plant invaders. We explored the merits of using LiDAR-derived metrics alone and through integration with spectral data to detect the spatial distribution of the exotic understory plant Ligustrum sinense, a rapidly spreading invader in the urbanizing region of Charlotte, North Carolina, USA. We analyzed regional-scale L. sinense occurrence data collected over the course of three years with LiDAR-derived metrics of forest structure that were categorized into the following groups: overstory, understory, topography, and overall vegetation characteristics, and IKONOS spectral features - optical. Using random forest (RF) and logistic regression (LR) classifiers, we assessed the relative contributions of LiDAR and IKONOS derived variables to the detection of L. sinense. We compared the top performing models developed for a smaller, nested experimental extent using RF and LR classifiers, and used the best overall model to produce a predictive map of the spatial distribution of L. sinense across our country-wide study extent. RF classification of LiDAR-derived topography metrics produced the highest mapping accuracy estimates, outperforming IKONOS data by 17.5% and the integration of LiDAR and IKONOS data by 5.3%. The top performing model from the RF classifier produced the highest kappa of 64.8%, improving on the parsimonious LR model kappa by 31.1% with a moderate gain of 6.2% over the county extent model. Our results demonstrate the superiority of LiDAR-derived metrics over spectral data and fusion of LiDAR and spectral data for accurately mapping the spatial distribution of the forest understory invader L. sinense.

The Role of eIF4E Activity in Breast Cancer

DTIC Science & Technology

2010-08-01

marker with some success. Furthermore, eIF4E is an established target for cancer therapy [3] and clinical trials of the efficacy and safety of cancer...individual group was small, for overall survival (OS), disease-free survival (DFS) and disease- specific survival ( DSS ) (Figure 2). High eIF4E scores were...indicative of poor prognosis. Prognosis seemed to worsen with each increasing eIF4E score for OS, whereas patterns for DFS and DSS sug- gested weaker

ICT and e-Governance: A Conceptual Model of e-DISC

NASA Astrophysics Data System (ADS)

Tejasvee, Sanjay; Sarangdevot, S. S.; Gahlot, Devendra; Gour, Vishal; Sandal, Shruti

2010-11-01

One of the most important objectives of e-governance is, proper distribution and delivery of government information and services to the citizens. By progression in resources of information technology, great opportunities comes to the government for serve information and services to the citizens and public sector in better manner. This paper intends to examine and explore the conceptual model of e-DISC (Effective Deliverance of Information and Services to the Citizens) The purpose of this paper is to gain a better understanding of e-government in India with the concept of e-DISC with ICTs and how to deal with challenges and barriers for successful e-DISC model with accuracy. The obtained results prove that the utilizing and by increasing interest in the new electronic, information, and communication technologies (ICTs) and e-DISC model in recent time, government improved the quality of e-governance and delivery of information and services and acknowledged the awareness of the system is also valuable.

Integrating LiDAR Data into Earth Science Education

NASA Astrophysics Data System (ADS)

Robinson, S. E.; Arrowsmith, R.; de Groot, R. M.; Crosby, C. J.; Whitesides, A. S.; Colunga, J.

2010-12-01

The use of high-resolution topography derived from Light Detection and Ranging (LiDAR) in the study of active tectonics is widespread and has become an indispensable tool to better understand earthquake hazards. For this reason and the spectacular representation of the phenomena the data provide, it is appropriate to integrate these data into the Earth science education curriculum. A collaboration between Arizona State University, the OpenTopography Facility, and the Southern California Earthquake Center are developing, three earth science education products to inform students and other audiences about LiDAR and its application to active tectonics research. First, a 10-minute introductory video titled LiDAR: Illuminating Earthquakes was produced and is freely available online through the OpenTopography portal and SCEC. The second product is an update and enhancement of the Wallace Creek Interpretive Trail website (www.scec.org/wallacecreek). LiDAR topography data products have been added along with the development of a virtual tour of the offset channels at Wallace Creek using the B4 LiDAR data within the Google Earth environment. The virtual tour to Wallace Creek is designed as a lab activity for introductory undergraduate geology courses to increase understanding of earthquake hazards through exploration of the dramatic offset created by the San Andreas Fault (SAF) at Wallace Creek and Global Positioning System-derived displacements spanning the SAF at Wallace Creek . This activity is currently being tested in courses at Arizona State University. The goal of the assessment is to measure student understanding of plate tectonics and earthquakes after completing the activity. Including high-resolution topography LiDAR data into the earth science education curriculum promotes understanding of plate tectonics, faults, and other topics related to earthquake hazards.

40 CFR Figure E-2 to Subpart E of... - Product Manufacturing Checklist

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 5 2011-07-01 2011-07-01 false Product Manufacturing Checklist E Figure E-2 to Subpart E of Part 53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Equivalent Methods for PM2.5 or PM10â2.5 Pt. 53, Subpt. E, Fig. E-2 Figure E-2 to Subpart E of Part 53...

40 CFR Figure E-2 to Subpart E of... - Product Manufacturing Checklist

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Product Manufacturing Checklist E Figure E-2 to Subpart E of Part 53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Equivalent Methods for PM2.5 or PM10â2.5 Pt. 53, Subpt. E, Fig. E-2 Figure E-2 to Subpart E of Part 53...

Triply differential (e,2e) studies of phenol.

PubMed

da Silva, G B; Neves, R F C; Chiari, L; Jones, D B; Ali, E; Madison, D H; Ning, C G; Nixon, K L; Lopes, M C A; Brunger, M J

2014-09-28

We have measured (e,2e) triple differential cross sections (TDCS) for the electron-impact ionisation of phenol with coplanar asymmetrical kinematics for an incident electron energy of 250 eV. Experimental measurements of the angular distribution of the slow outgoing electrons at 20 eV are obtained when the incident electron scatters through angles of -5°, -10°, and -15°, respectively. The TDCS data are compared with calculations performed within the molecular 3-body distorted wave model. In this case, a mixed level of agreement, that was dependent on the kinematical condition being probed, was observed between the theoretical and experimental results in the binary peak region. The experimental intensity of the recoil features under all kinematical conditions was relatively small, but was still largely underestimated by the theoretical calculations.

Triply differential (e,2e) studies of phenol

NASA Astrophysics Data System (ADS)

da Silva, G. B.; Neves, R. F. C.; Chiari, L.; Jones, D. B.; Ali, E.; Madison, D. H.; Ning, C. G.; Nixon, K. L.; Lopes, M. C. A.; Brunger, M. J.

2014-09-01

We have measured (e,2e) triple differential cross sections (TDCS) for the electron-impact ionisation of phenol with coplanar asymmetrical kinematics for an incident electron energy of 250 eV. Experimental measurements of the angular distribution of the slow outgoing electrons at 20 eV are obtained when the incident electron scatters through angles of -5°, -10°, and -15°, respectively. The TDCS data are compared with calculations performed within the molecular 3-body distorted wave model. In this case, a mixed level of agreement, that was dependent on the kinematical condition being probed, was observed between the theoretical and experimental results in the binary peak region. The experimental intensity of the recoil features under all kinematical conditions was relatively small, but was still largely underestimated by the theoretical calculations.

Smokers' and E-Cigarette Users' Perceptions about E-Cigarette Warning Statements.

PubMed

Wackowski, Olivia A; Hammond, David; O'Connor, Richard J; Strasser, Andrew A; Delnevo, Cristine D

2016-06-30

Cigarette warning labels are important sources of risk information, but warning research for other tobacco products is limited. This study aimed to gauge perceptions about warnings that may be used for e-cigarettes. We conducted six small focus groups in late 2014/early 2015 with adult current e-cigarette users and cigarette-only smokers. Participants rated and discussed their perceptions of six e-cigarette warning statements, and warnings in two existing Vuse and MarkTen e-cigarette ads. Participants were open to e-cigarette warnings and provided the strongest reactions to statements warning that e-liquid/e-vapor or e-cigarettes can be poisonous, contain toxins, or are "not a safe alternative to smoking". However, many also noted that these statements were exaggerated, potentially misleading, and could scare smokers away from reducing their harm by switching to e-cigarettes. Opinions on the Food and Drug Administration's proposed nicotine addiction warning and warnings that e-cigarettes had not been approved for smoking cessation or had unknown health effects were mixed. Participants perceived MarkTen's advertisement warning to be stronger and more noticeable than Vuse's. Care should be taken in developing e-cigarette warnings given their relative recentness and potential for harm reduction compared to other tobacco products. Additional research, including with varied audiences, would be instructive.

The Fate of Bacterial Cocaine Esterase (CocE): An In Vivo Study of CocE-Mediated Cocaine Hydrolysis, CocE Pharmacokinetics, and CocE EliminationS⃞

PubMed Central

Brim, Remy L.; Noon, Kathleen R.; Collins, Gregory T.; Stein, Aron; Nichols, Joseph; Narasimhan, Diwa; Ko, Mei-Chuan; Woods, James H.

2012-01-01

Cocaine abuse and toxicity remain widespread problems in the United States. Currently cocaine toxicity is treated only symptomatically, because there is no Food and Drug Administration-approved pharmacotherapy for this indication. To address the unmet need, a stabilized mutant of bacterial cocaine esterase [T172R/G173Q-CocE (DM-CocE)], which hydrolyzes cocaine into inactive metabolites and has low immunogenic potential, has been developed and previously tested in animal models of cocaine toxicity. Here, we document the rapid cocaine hydrolysis by low doses of DM-CocE in vitro and in vivo, as well as the pharmacokinetics and distribution of the DM-CocE protein in rats. DM-CocE at 50.5 μg/kg effectively eliminated 4 mg/kg cocaine within 2 min in both male and female rats as measured by mass spectrometry. We expanded on these findings by using a pharmacologically relevant dose of DM-CocE (0.32 mg/kg) in rats and monkeys to hydrolyze convulsant doses of cocaine. DM-CocE reduced cocaine to below detection limits rapidly after injection; however, elimination of DM-CocE resulted in peripheral cocaine redistribution by 30 to 60 min. Elimination of DM-CocE was quantified by using [35S] labeling of the enzyme and was found to have a half-life of 2.1 h in rats. Minor urinary output of DM-CocE was also observed. Immunohistochemistry, Western blotting, and radiography all were used to elucidate the mechanism of DM-CocE elimination, rapid proteolysis, and recycling of amino acids into all tissues. This rapid elimination of DM-CocE is a desirable property of a therapeutic for cocaine toxicity and should reduce the likelihood of immunogenic or adverse reactions as DM-CocE moves toward clinical use. PMID:21990608

DArT Markers Effectively Target Gene Space in the Rye Genome

PubMed Central

Gawroński, Piotr; Pawełkowicz, Magdalena; Tofil, Katarzyna; Uszyński, Grzegorz; Sharifova, Saida; Ahluwalia, Shivaksh; Tyrka, Mirosław; Wędzony, Maria; Kilian, Andrzej; Bolibok-Brągoszewska, Hanna

2016-01-01

Large genome size and complexity hamper considerably the genomics research in relevant species. Rye (Secale cereale L.) has one of the largest genomes among cereal crops and repetitive sequences account for over 90% of its length. Diversity Arrays Technology is a high-throughput genotyping method, in which a preferential sampling of gene-rich regions is achieved through the use of methylation sensitive restriction enzymes. We obtained sequences of 6,177 rye DArT markers and following a redundancy analysis assembled them into 3,737 non-redundant sequences, which were then used in homology searches against five Pooideae sequence sets. In total 515 DArT sequences could be incorporated into publicly available rye genome zippers providing a starting point for the integration of DArT- and transcript-based genomics resources in rye. Using Blast2Go pipeline we attributed putative gene functions to 1101 (29.4%) of the non-redundant DArT marker sequences, including 132 sequences with putative disease resistance-related functions, which were found to be preferentially located in the 4RL and 6RL chromosomes. Comparative analysis based on the DArT sequences revealed obvious inconsistencies between two recently published high density consensus maps of rye. Furthermore we demonstrated that DArT marker sequences can be a source of SSR polymorphisms. Obtained data demonstrate that DArT markers effectively target gene space in the large, complex, and repetitive rye genome. Through the annotation of putative gene functions and the alignment of DArT sequences relative to reference genomes we obtained information, that will complement the results of the studies, where DArT genotyping was deployed, by simplifying the gene ontology and microcolinearity based identification of candidate genes. PMID:27833625

How integrating 3D LiDAR data in the dike surveillance protocol: The French case

NASA Astrophysics Data System (ADS)

Bretar, F.; Mériaux, P.; Fauchard, C.

2012-04-01

The recent and dramatic floods of the last years in Europe (e.g. Rhône river major flood, December 2003, Windstorm Xynthia, February 2010, in France) and in the United-States (Hurricane Katrina, August 2005) showed the vulnerability of flood or coastal defence systems. The first key point for avoiding these dramatic damages and the high cost of a failure and its consequences lies in the appropriate conception and construction of the dikes, but above all in the relevance of the surveillance protocol. Many factors introduce weaknesses in the fluvial or maritime dikes. Most of them are old embankment structures. For instance, some of the French Loire River dikes were built several centuries ago. They may have been rebuilt, modified, heightened several times, with some materials that do not necessarily match the original conception of the structure. In other respects, tree roots or animal burrows could modify the structure of the dike and reduce the watertightness or mechanical properties. The French government has built a national database, "BarDigues", since 1999 to inventory and characterize dikes. Today, there are approx. 9000 km of dikes protecting 1.5 to 2 millions of people. In the meantime, a GIS application, called « Dike SIRS » [Maurel P., 2004] , provides an operational and accurate tool to several great stakeholders in charge of managing more than 100 km of dikes. Today, the dike surveillance and diagnosis protocol consists in identifying the weaknesses of the structure and providing the degree of safety by making a preliminary study (historical research, geological and morphodynamic study, topography), geophysical study (e.g. electromagnetic methods and electrical resistivity tomography) and at last geotechnical study (e.g. drillings and stability modelling) at the very local scale when necessary [Mériaux P. & Royet P, 2007] . Considering the stretch of hundreds of kilometres, rapid, cost-effective and reliable techniques for surveying the dike must be

Smokers’ and E-Cigarette Users’ Perceptions about E-Cigarette Warning Statements

PubMed Central

Wackowski, Olivia A.; Hammond, David; O’Connor, Richard J.; Strasser, Andrew A.; Delnevo, Cristine D.

2016-01-01

Cigarette warning labels are important sources of risk information, but warning research for other tobacco products is limited. This study aimed to gauge perceptions about warnings that may be used for e-cigarettes. We conducted six small focus groups in late 2014/early 2015 with adult current e-cigarette users and cigarette-only smokers. Participants rated and discussed their perceptions of six e-cigarette warning statements, and warnings in two existing Vuse and MarkTen e-cigarette ads. Participants were open to e-cigarette warnings and provided the strongest reactions to statements warning that e-liquid/e-vapor or e-cigarettes can be poisonous, contain toxins, or are “not a safe alternative to smoking”. However, many also noted that these statements were exaggerated, potentially misleading, and could scare smokers away from reducing their harm by switching to e-cigarettes. Opinions on the Food and Drug Administration’s proposed nicotine addiction warning and warnings that e-cigarettes had not been approved for smoking cessation or had unknown health effects were mixed. Participants perceived MarkTen’s advertisement warning to be stronger and more noticeable than Vuse’s. Care should be taken in developing e-cigarette warnings given their relative recentness and potential for harm reduction compared to other tobacco products. Additional research, including with varied audiences, would be instructive. PMID:27376310

Transannular E···E' Interactions in Neutral, Radical Cationic, and Dicationic Forms of cyclo-[E(CH2CH2CH2)2E'] (E, E' = S, Se, Te, and O) with Structural Feature: Dynamic and Static Behavior of E···E' Elucidated by QTAIM Dual Functional Analysis.

PubMed

Hayashi, Satoko; Matsuiwa, Kohei; Nishizawa, Nozomu; Nakanishi, Waro

2015-12-18

The nature of the transannular E-∗-E' interactions in neutral, radical cationic, and dicationic forms of cyclo-E(CH2CH2CH2)2E' (1) (E, E' = S, Se, Te, and O) (1, 1(•+), and 1(2+), respectively) is elucidated by applying QTAIM dual functional analysis (QTAIM-DFA). Hb(rc) are plotted versus Hb(rc) - Vb(rc)/2 for the data of E-∗-E' at BCPs in QTAIM-DFA, where ∗ emphasizes the existence of BCP. Plots for the fully optimized structures are analyzed by the polar coordinate (R, θ) representation. Those containing the perturbed structures are by (θp, κp): θp corresponds to the tangent line of the plot, and κp is the curvature. While (R, θ) describes the static nature, (θp, κp) represents the dynamic nature of interactions. The nature is well-specified by (R, θ) and (θp, κp). E-∗-E' becomes stronger in the order of 1 < 1(•+) < 1(2+), except for O-∗-O. While E-∗-E' (E, E' = S, Se, and Te) in 1(2+) are characterized as weak covalent bonds, except for S-∗-Te (MC nature through CT) and Se-∗-Te (TBP nature through CT), O-∗-E' seems more complex. The behavior of E-∗-E' in 1(2+) is very close to that of cyclo-E(CH2CH2CH2)E' (E, E' = S, Se, Te, and O), except for O-∗-O.

LiDAR: Providing structure

USGS Publications Warehouse

Vierling, Lee A.; Martinuzzi, Sebastián; Asner, Gregory P.; Stoker, Jason M.; Johnson, Brian R.

2011-01-01

Since the days of MacArthur, three-dimensional (3-D) structural information on the environment has fundamentally transformed scientific understanding of ecological phenomena (MacArthur and MacArthur 1961). Early data on ecosystem structure were painstakingly laborious to collect. However, as reviewed and reported in recent volumes of Frontiers(eg Vierling et al. 2008; Asner et al.2011), advances in light detection and ranging (LiDAR) remote-sensing technology provide quantitative and repeatable measurements of 3-D ecosystem structure that enable novel ecological insights at scales ranging from the plot, to the landscape, to the globe. Indeed, annual publication of studies using LiDAR to interpret ecological phenomena increased 17-fold during the past decade, with over 180 new studies appearing in 2010 (ISI Web of Science search conducted on 23 Mar 2011: [{lidar AND ecol*} OR {lidar AND fores*} OR {lidar AND plant*}]).

Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

DOE PAGES

Di Mauro, M.; Manconi, S.; Vittino, A.; ...

2017-08-17

The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Mauro, M.; Manconi, S.; Vittino, A.

The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

Temporal transferability of LiDAR-based imputation of forest structure attributes

Treesearch

Patrick A. Fekety; Michael J. Falkowski; Andrew T. Hudak

2015-01-01

Forest inventory and planning decisions are frequently informed by LiDAR data. Repeated LiDAR acquisitions offer an opportunity to update forest inventories and potentially improve forest inventory estimates through time. We leveraged repeated LiDAR and ground measures for a study area in northern Idaho, U.S.A., to predict (via imputation) - across both space and time-...

Relationship between LiDAR-derived forest canopy height and Landsat images

Treesearch

Cristina Pascual; Antonio Garcia-Abril; Warren B. Cohen; Susana Martin-Fernandez

2010-01-01

The mean and standard deviation (SD) of light detection and ranging (LiDAR)-derived canopy height are related to forest structure. However, LiDAR data typically cover a limited area and have a high economic cost compared with satellite optical imagery. Optical images may be required to extrapolate LiDAR height measurements across a broad landscape. Different spectral...

Semantic e-Learning: Next Generation of e-Learning?

NASA Astrophysics Data System (ADS)

Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

Search for Long-Lived Particles in e+e- Collisions

NASA Astrophysics Data System (ADS)

Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Kerth, L. T.; Kolomensky, Yu. G.; Lee, M. J.; Lynch, G.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Dey, B.; Gary, J. W.; Long, O.; Campagnari, C.; Franco Sevilla, M.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Bernard, D.; Verderi, M.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Piemontese, L.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Lo Vetere, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Bhuyan, B.; Prasad, V.; Adametz, A.; Uwer, U.; Lacker, H. M.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; di Lodovico, F.; Sacco, R.; Cowan, G.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Sciolla, G.; Cheaib, R.; Patel, P. M.; Robertson, S. H.; Neri, N.; Palombo, F.; Cremaldi, L.; Godang, R.; Sonnek, P.; Summers, D. J.; Simard, M.; Taras, P.; de Nardo, G.; Onorato, G.; Sciacca, C.; Martinelli, M.; Raven, G.; Jessop, C. P.; Losecco, J. M.; Honscheid, K.; Kass, R.; Feltresi, E.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Pacetti, S.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Cervelli, A.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Perez, A.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Hess, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Bard, D. J.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Lindemann, D.; Luitz, S.; Luth, V.; Lynch, H. L.; Macfarlane, D. B.; Muller, D. R.; Neal, H.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'Vra, J.; Wisniewski, W. J.; Wulsin, H. W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Wray, B. C.; Izen, J. M.; Lou, X. C.; Bianchi, F.; de Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P.; Albert, J.; Banerjee, Sw.; Beaulieu, A.; Bernlochner, F. U.; Choi, H. H. F.; King, G. J.; Kowalewski, R.; Lewczuk, M. J.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Band, H. R.; Dasu, S.; Pan, Y.; Prepost, R.; Wu, S. L.; Babar Collaboration

2015-05-01

We present a search for a neutral, long-lived particle L that is produced in e+e- collisions and decays at a significant distance from the e+e- interaction point into various flavor combinations of two oppositely charged tracks. The analysis uses an e+e- data sample with a luminosity of 489.1 fb-1 collected by the BABAR detector at the ϒ (4 S ) , ϒ (3 S ) , and ϒ (2 S ) resonances and just below the ϒ (4 S ) . Fitting the two-track mass distribution in search of a signal peak, we do not observe a significant signal, and set 90% confidence level upper limits on the product of the L production cross section, branching fraction, and reconstruction efficiency for six possible two-body L decay modes as a function of the L mass. The efficiency is given for each final state as a function of the mass, lifetime, and transverse momentum of the candidate, allowing application of the upper limits to any production model. In addition, upper limits are provided on the branching fraction B (B →XsL ) , where Xs is a strange hadronic system.

Search for Long-Lived Particles in e+ e- Collisions.

PubMed

Lees, J P; Poireau, V; Tisserand, V; Grauges, E; Palano, A; Eigen, G; Stugu, B; Brown, D N; Kerth, L T; Kolomensky, Yu G; Lee, M J; Lynch, G; Koch, H; Schroeder, T; Hearty, C; Mattison, T S; McKenna, J A; So, R Y; Khan, A; Blinov, V E; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Lankford, A J; Dey, B; Gary, J W; Long, O; Campagnari, C; Franco Sevilla, M; Hong, T M; Kovalskyi, D; Richman, J D; West, C A; Eisner, A M; Lockman, W S; Panduro Vazquez, W; Schumm, B A; Seiden, A; Chao, D S; Cheng, C H; Echenard, B; Flood, K T; Hitlin, D G; Miyashita, T S; Ongmongkolkul, P; Porter, F C; Röhrken, M; Andreassen, R; Huard, Z; Meadows, B T; Pushpawela, B G; Sokoloff, M D; Sun, L; Bloom, P C; Ford, W T; Gaz, A; Smith, J G; Wagner, S R; Ayad, R; Toki, W H; Spaan, B; Bernard, D; Verderi, M; Playfer, S; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Fioravanti, E; Garzia, I; Luppi, E; Piemontese, L; Santoro, V; Calcaterra, A; de Sangro, R; Finocchiaro, G; Martellotti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Contri, R; Lo Vetere, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Bhuyan, B; Prasad, V; Adametz, A; Uwer, U; Lacker, H M; Mallik, U; Chen, C; Cochran, J; Prell, S; Ahmed, H; Gritsan, A V; Arnaud, N; Davier, M; Derkach, D; Grosdidier, G; Le Diberder, F; Lutz, A M; Malaescu, B; Roudeau, P; Stocchi, A; Wormser, G; Lange, D J; Wright, D M; Coleman, J P; Fry, J R; Gabathuler, E; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; Di Lodovico, F; Sacco, R; Cowan, G; Brown, D N; Davis, C L; Denig, A G; Fritsch, M; Gradl, W; Griessinger, K; Hafner, A; Schubert, K R; Barlow, R J; Lafferty, G D; Cenci, R; Hamilton, B; Jawahery, A; Roberts, D A; Cowan, R; Sciolla, G; Cheaib, R; Patel, P M; Robertson, S H; Neri, N; Palombo, F; Cremaldi, L; Godang, R; Sonnek, P; Summers, D J; Simard, M; Taras, P; De Nardo, G; Onorato, G; Sciacca, C; Martinelli, M; Raven, G; Jessop, C P; LoSecco, J M; Honscheid, K; Kass, R; Feltresi, E; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simi, G; Simonetto, F; Stroili, R; Akar, S; Ben-Haim, E; Bomben, M; Bonneaud, G R; Briand, H; Calderini, G; Chauveau, J; Leruste, Ph; Marchiori, G; Ocariz, J; Biasini, M; Manoni, E; Pacetti, S; Rossi, A; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Casarosa, G; Cervelli, A; Chrzaszcz, M; Forti, F; Giorgi, M A; Lusiani, A; Oberhof, B; Paoloni, E; Perez, A; Rizzo, G; Walsh, J J; Lopes Pegna, D; Olsen, J; Smith, A J S; Anulli, F; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Pilloni, A; Piredda, G; Bünger, C; Dittrich, S; Grünberg, O; Hess, M; Leddig, T; Voß, C; Waldi, R; Adye, T; Olaiya, E O; Wilson, F F; Emery, S; Vasseur, G; Aston, D; Bard, D J; Cartaro, C; Convery, M R; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Ebert, M; Field, R C; Fulsom, B G; Graham, M T; Hast, C; Innes, W R; Kim, P; Leith, D W G S; Lindemann, D; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Muller, D R; Neal, H; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Snyder, A; Su, D; Sullivan, M K; Va'vra, J; Wisniewski, W J; Wulsin, H W; Purohit, M V; White, R M; Wilson, J R; Randle-Conde, A; Sekula, S J; Bellis, M; Burchat, P R; Puccio, E M T; Alam, M S; Ernst, J A; Gorodeisky, R; Guttman, N; Peimer, D R; Soffer, A; Spanier, S M; Ritchie, J L; Schwitters, R F; Wray, B C; Izen, J M; Lou, X C; Bianchi, F; De Mori, F; Filippi, A; Gamba, D; Lanceri, L; Vitale, L; Martinez-Vidal, F; Oyanguren, A; Villanueva-Perez, P; Albert, J; Banerjee, Sw; Beaulieu, A; Bernlochner, F U; Choi, H H F; King, G J; Kowalewski, R; Lewczuk, M J; Lueck, T; Nugent, I M; Roney, J M; Sobie, R J; Tasneem, N; Gershon, T J; Harrison, P F; Latham, T E; Band, H R; Dasu, S; Pan, Y; Prepost, R; Wu, S L

2015-05-01

We present a search for a neutral, long-lived particle L that is produced in e+ e- collisions and decays at a significant distance from the e+ e- interaction point into various flavor combinations of two oppositely charged tracks. The analysis uses an e+ e- data sample with a luminosity of 489.1  fb(-1) collected by the BABAR detector at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and just below the ϒ(4S). Fitting the two-track mass distribution in search of a signal peak, we do not observe a significant signal, and set 90% confidence level upper limits on the product of the L production cross section, branching fraction, and reconstruction efficiency for six possible two-body L decay modes as a function of the L mass. The efficiency is given for each final state as a function of the mass, lifetime, and transverse momentum of the candidate, allowing application of the upper limits to any production model. In addition, upper limits are provided on the branching fraction B(B→XsL), where Xs is a strange hadronic system.

Search for Long-Lived Particles in e + e - Collisions

DOE PAGES

Lees, J. P.; Poireau, V.; Tisserand, V.; ...

2015-04-29

We present a search for a neutral, long-lived particle L that is produced in e +e - collisions and decays at a significant distance from the e +e - interaction point into various flavor combinations of two oppositely charged tracks. The analysis uses an e +e - data sample with a luminosity of 489.1 fb -1 collected by the BABAR detector at the γ (4S), γ (3S), and γ (2S) resonances and just below the γ (4S). Fitting the two-track mass distribution in search of a signal peak, we do not observe a significant signal, and set 90% confidence levelmore » upper limits on the product of the L production cross section, branching fraction, and reconstruction efficiency for six possible two-body L decay modes as a function of the L mass. The efficiency is given for each final state as a function of the mass, lifetime, and transverse momentum of the candidate, allowing application of the upper limits to any production model. In addition, upper limits are provided on the branching fraction B(B→X sL), where X s is a strange hadronic system.« less

E3 Success Story - Accelerating Adoption of E3 Recommendations

EPA Pesticide Factsheets

The state of Michigan, along with numerous local and state partners, formed E3 Michigan in 2010. This partnership will allow for up to 10 E3 assessments in southeast Michigan and 10 E3 assessments in western Michigan.

New perspective of Grodzins E × B(E2) ↑ product rule

NASA Astrophysics Data System (ADS)

Gupta, J. B.; Katoch, Vikas

In the collective spectra of atomic nuclei, the level energy E(21+) varies with atomic number Z and neutron number N. Also the E2 decay-reduced transition probability B(E2, 01+ → 2 1+) is related to the energy E(21+). The product E(21+) × B(E2) ↑ is constant according to Grodzins product rule, independent of the vibration or rotational status of the nucleus. The product rule is often used for determining B(E2) from the known E(21+). However, the variation of the product with various parameters is also suggested in the literature. Hence, a detailed global study of this rule for (Z = 54‑‑78, 66 < N < 126) region is warranted. We use a novel method of displaying the linear relation of B(E2) ↑ with 1/E(21+) for the isotopes of each element (Xe-Pt), instead of their variation with N,Z or A. Through our work, we firmly establish the global validity of the Grodzins relation of B(E2), being proportional to the moment of inertia, except for the deviation in specific cases. Our B(E2) ↑ versus 1/E plots provide a transparent view of the variation of the low-energy nuclear structure. This gives a new perspective of their nuclear structure. Also the various theoretical interpretations of B(E2)s and the energy E(21+) are reviewed.

Delayed recovery of adipsic diabetes insipidus (ADI) caused by elective clipping of anterior communicating artery and left middle cerebral artery aneurysms.

PubMed

Tan, Jeffrey; Ndoro, Samuel; Okafo, Uchenna; Garrahy, Aoife; Agha, Amar; Rawluk, Danny

2016-12-16

Adipsic diabetes insipidus (ADI) is an extremely rare complication following microsurgical clipping of anterior communicating artery aneurysm (ACoA) and left middle cerebral artery (MCA) aneurysm. It poses a significant challenge to manage due to an absent thirst response and the co-existence of cognitive impairment in our patient. Recovery from adipsic DI has hitherto been reported only once. A 52-year-old man with previous history of clipping of left posterior communicating artery aneurysm 20 years prior underwent microsurgical clipping of ACoA and left MCA aneurysms without any intraoperative complications. Shortly after surgery, he developed clear features of ADI with adipsic severe hypernatraemia and hypotonic polyuria, which was associated with cognitive impairment that was confirmed with biochemical investigations and cognitive assessments. He was treated with DDAVP along with a strict intake of oral fluids at scheduled times to maintain eunatremia. Repeat assessment at six months showed recovery of thirst and a normal water deprivation test. Management of ADI with cognitive impairment is complex and requires a multidisciplinary approach. Recovery from ADI is very rare, and this is only the second report of recovery in this particular clinical setting.

Significant effect of topographic normalization of airborne LiDAR data on the retrieval of plant area index profile in mountainous forests

NASA Astrophysics Data System (ADS)

Liu, Jing; Skidmore, Andrew K.; Heurich, Marco; Wang, Tiejun

2017-10-01

As an important metric for describing vertical forest structure, the plant area index (PAI) profile is used for many applications including biomass estimation and wildlife habitat assessment. PAI profiles can be estimated with the vertically resolved gap fraction from airborne LiDAR data. Most research utilizes a height normalization algorithm to retrieve local or relative height by assuming the terrain to be flat. However, for many forests this assumption is not valid. In this research, the effect of topographic normalization of airborne LiDAR data on the retrieval of PAI profile was studied in a mountainous forest area in Germany. Results show that, although individual tree height may be retained after topographic normalization, the spatial arrangement of trees is changed. Specifically, topographic normalization vertically condenses and distorts the PAI profile, which consequently alters the distribution pattern of plant area density in space. This effect becomes more evident as the slope increases. Furthermore, topographic normalization may also undermine the complexity (i.e., canopy layer number and entropy) of the PAI profile. The decrease in PAI profile complexity is not solely determined by local topography, but is determined by the interaction between local topography and the spatial distribution of each tree. This research demonstrates that when calculating the PAI profile from airborne LiDAR data, local topography needs to be taken into account. We therefore suggest that for ecological applications, such as vertical forest structure analysis and modeling of biodiversity, topographic normalization should not be applied in non-flat areas when using LiDAR data.

Limits on a light Higgs boson in e+e- collisions at LEP

NASA Astrophysics Data System (ADS)

Akrawy, M. Z.; Alexander, G.; Allison, J.; Allport, P. P.; Anderson, K. J.; Armitage, J. C.; Arnison, G. T. J.; Ashton, P.; Azuelos, G.; Baines, J. T. M.; Ball, A. H.; Banks, J.; Barker, G. J.; Barlow, R. J.; Batley, J. R.; Beck, A.; Becker, J.; Behnke, T.; Bell, K. W.; Bella, G.; Bethke, S.; Biebel, O.; Binder, U.; Bloodworth, I. J.; Bock, P.; Breuker, H.; Brown, R. M.; Brun, R.; Buijs, A.; Burckhart, H. J.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Chrin, J. T. M.; Clarke, P. E. L.; Cohen, I.; Collins, W. J.; Conboy, J. E.; Couch, M.; Coupland, M.; Cuffiani, M.; Dado, S.; Dallavalle, G. M.; Debu, P.; Deninno, M. M.; Dieckmann, A.; Dittmar, M.; Dixit, M. S.; Duchovni, E.; Duerdoth, I. P.; Dumas, D.; Mamouni, H. El; Elcombe, P. A.; Estabrooks, P. G.; Etzion, E.; Fabbri, F.; Farthouat, P.; Fischer, H. M.; Fong, D. G.; French, M. T.; Fukunaga, C.; Gaidot, A.; Ganel, O.; Gary, J. W.; Gascon, J.; Geddes, N. I.; Gee, C. N. P.; Geich-Gimbel, C.; Gensler, S. W.; Gentit, F. X.; Giacomelli, G.; Gibson, V.; Gibson, W. R.; Gillies, J. D.; Goldberg, J.; Goodrick, M. J.; Gorn, W.; Granite, D.; Gross, E.; Grunhaus, J.; Hagedorn, H.; Hagemann, J.; Hansroul, M.; Hargrove, C. K.; Harris, I.; Hart, J.; Hattersley, P. M.; Hauschild, M.; Hawkes, C. M.; Heflin, E.; Hemingway, R. J.; Heuer, R. D.; Hill, J. C.; Hillier, S. J.; Ho, C.; Hobbs, J. D.; Hobson, P. R.; Hochman, D.; Holl, B.; Homer, R. J.; Hou, S. R.; Howarth, C. P.; Hughes-Jones, R. E.; Humbert, R.; Igo-Kemenes, P.; Ihssen, H.; Imrie, D. C.; Janissen, J.; Jawahery, A.; Jeffreys, P. W.; Jeremie, H.; Jimack, M.; Jobes, M.; Jones, R. W. L.; Jovanovic, P.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Kellogg, R. G.; Kennedy, B. W.; Kleinwort, C.; Klem, D. E.; Knop, G.; Kobayashi, T.; Kokott, T. P.; Köpke, L.; Kowalewski, R.; Kreutzmann, H.; Kroll, J.; Kuwano, M.; Kyberd, P.; Lafferty, G. D.; Lamarche, F.; Larson, W. J.; Layter, J. G.; Du, P. Le; Leblanc, P.; Lee, A. M.; Lehto, M. H.; Lellouch, D.; Lennert, P.; Lessard, L.; Levinson, L.; Llyod, S. L.; Loebinger, F. K.; Lorah, J. M.; Lorazo, B.; Losty, M. J.; Ludwig, J.; Ma, J.; MacBeth, A. A.; Mannelli, M.; Marcellini, S.; Maringer, G.; Martin, A. J.; Martin, J. P.; Mashimo, T.; Mättig, P.; Maur, U.; McMahon, T. J.; McNutt, J. R.; Meijers, F.; Menszner, D.; Merritt, F. S.; Mes, H.; Michelini, A.; Middleton, R. P.; Mikenberg, G.; Mildenberger, J.; Miller, D. J.; Milstene, C.; Minowa, M.; Mohr, W.; Montanari, A.; Mori, T.; Moss, M. W.; Murphy, P. G.; Murray, W. J.; Nellen, B.; Nguyen, H. H.; Nozaki, M.; O'Dowd, A. J. P.; O'Neale, S. W.; O'Neill, B. P.; Oakham, F. G.; Odorici, F.; Ogg, M.; Oh, H.; Oreglia, M. J.; Orito, S.; Pansart, J. P.; Patrick, G. N.; Pawley, S. J.; Pfister, P.; Pilcher, J. E.; Pinfold, J. L.; Plane, D. E.; Poli, B.; Pouladdej, A.; Prebys, E.; Pritchard, T. W.; Quast, G.; Raab, J.; Redmond, M. W.; Rees, D. L.; Regimbald, M.; Riles, K.; Roach, C. M.; Robins, S. A.; Rollnik, A.; Roney, J. M.; Rossberg, S.; Rossi, A. M.; Routenburg, P.; Runge, K.; Runolfsson, O.; Sanghera, S.; Sansum, R. A.; Sasaki, M.; Saunders, B. J.; Schaile, A. D.; Schaile, O.; Schappert, W.; Scharff-Hansen, P.; Schreiber, S.; Schwarz, J.; Shapira, A.; Shen, B. C.; Sherwood, P.; Simon, A.; Siroli, G. P.; Skuja, A.; Smith, A. M.; Smith, T. J.; Snow, G. A.; Springer, R. W.; Sproston, M.; Stephens, K.; Stier, H. E.; Ströhmer, R.; Strom, D.; Takeda, H.; Takeshita, T.; Thackray, N. J.; Tsukamoto, T.; Turner, M. F.; Tysarczyk-Niemeyer, G.; van den Plas, D.; Vandalen, G. J.; Vasseur, G.; Virtue, C. J.; von der Schmitt, H.; von Krogh, J.; Wagner, A.; Wahl, C.; Walker, J. P.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Weber, M.; Weisz, S.; Wells, P. S.; Wermes, N.; Weymann, M.; Wilson, G. W.; Wilson, J. A.; Wingerter, I.; Winterer, V.-H.; Wood, N. C.; Wotton, S.; Wuensch, B.; Wyatt, T. R.; Yaari, R.; Yang, Y.; Yekutieli, G.; Yoshida, T.; Zeuner, W.; Zorn, G. T.

1990-11-01

Data from e+e- collisions collected with the OPAL detector at LEP have been used to exclude a standard model Higgs boson (H0) with mass below 2mμ. The analysis used 1.2 pb-1 of data taken at centre-of-mass energies between 88.3 and 95.0 GeV to search for the reactions e+e--->Z0H0, (Z0-->e+e- or μ+μ-, H0-->undetected), e+e--->Z0H0, (Z0-->νν, H0-->e+e- or γγ). The existence of a minimal standard model H0 with mass in the range 0<=mH<=2mμ is excluded at the 95% confidence level. The limit is also valid for standard model extensions with a large branching ratio for the decay of H0 to γγ.

Intraday monitoring of granitic exfoliation sheets with LiDAR and thermal imaging (Yosemite Valley, California, USA)

NASA Astrophysics Data System (ADS)

Guerin, Antoine; Derron, Marc-Henri; Jaboyedoff, Michel; Abellán, Antonio; Dubas, Olivier; Collins, Brian D.; Stock, Greg M.

2016-04-01

Rockfall activity in Yosemite Valley is often linked to the presence of exfoliation sheets associated with other structures such as faults, joints or geological contacts. Daily and seasonal temperature variations or freeze-thaw cycles may strongly promote crack propagation along discontinuities, ultimately leading to rockfalls (Stock et al., 2013). However, little is known concerning the impact of thermal variations on rock face deformation, despite its occurrence at all times of year. To understand the influence of daily temperature fluctuations on the behavior of exfoliation joints (i.e., fractures separating exfoliation sheets), we carried out two different experiments in October 2015: (a) We first monitored a sub-vertical granodiorite flake (19 m by 4 m by 0.1 m ; Collins and Stock, 2014) for 24 consecutive hours using LiDAR and infrared thermal sensors; (b) We monitored a rock cliff (60 m by 45 m) composed of tens of exfoliation sheets located on the southeast face of El Capitan (an ~1000-m-tall cliff located in western Yosemite Valley) for several hours (from 05:30 pm to 01:30 am) to investigate the diurnal cooling effect on rocks of different lithologies. To calibrate the raw apparent temperature measured by the thermal imager (FLIR T660 infrared camera), we fixed pieces of reflective paper (aluminum foil) and black duct tape on both monitored cliffs to measure the reflected temperature and the emissivity of the different rocks. In addition, ambient temperature and relative humidity readings were performed for each acquisition. We then compared the calibrated temperatures to the values registered by resistance temperature detectors (Pt100 sensors), also attached to the rock. Finally, we compared the millimeter scale deformations observed with LiDAR to the values measured by manual crackmeters (standard analog comparators with springs) installed beforehand in the fractures. For the first experiment (24-hour monitoring), a series of measurements were carried

Vitamin E Nicotinate

PubMed Central

Duncan, Kimbell R.; Suzuki, Yuichiro J.

2017-01-01

Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications. The forms of vitamin E most studied are natural α-tocopherol and the esters α-tocopheryl acetate and α-tocopheryl succinate. A small number of studies include or focus on another ester form, α-tocopheryl nicotinate, an ester of vitamin E and niacin. Some of these studies raise the possibility of differences in metabolism and in efficacy between vitamin E nicotinate and other forms of vitamin E. Recently, through metabolomics studies, we identified that α-tocopheryl nicotinate occurs endogenously in the heart and that its level is dramatically decreased in heart failure, indicating the possible biological importance of this vitamin E ester. Since knowledge about vitamin E nicotinate is not readily available in the literature, the purpose of this review is to summarize and evaluate published reports, specifically with respect to α-tocopheryl nicotinate with an emphasis on the differences from natural α-tocopherol or α-tocopheryl acetate. PMID:28335380

E-cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure.

PubMed

DeVito, Elise E; Krishnan-Sarin, Suchitra

2018-01-01

Electronic cigarette (e-cigarette) use has increased substantially in recent years. While e-cigarettes have been proposed as a potentially effective smoking cessation tool, dualuse in smokers is common and e-cigarettes are widely used by non-smokers, including youth and young-adult non-smokers. Nicotine, the primary addictive component in cigarettes, is present at varying levels in many e-liquids. E-cigarettes may lead to initiation of nicotine use in adult and youth non-smokers, re-initiation of nicotine dependence in ex-smokers or increased severity of nicotine dependence in dual-users of cigarettes and e-cigarettes. As such, there are important clinical and policy implications to understanding factors impacting nicotine exposure from e-cigarettes. However, the broad and rapidly changing range of e-liquid constituents and e-cigarette hardware which could impact nicotine exposure presents a challenge. Recent changes in regulatory oversight of e-cigarettes underscore the importance of synthesizing current knowledge on common factors which may impact nicotine exposure. This review focuses on factors which may impact nicotine exposure by changing e-cigarette use behavior, puff topography, altering the nicotine yield (amount of nicotine exiting the e-cigarette mouth piece including nicotine exhaled as vapor) or more directly by altering nicotine absorption and bioavailability. Topics reviewed include e-liquid components or characteristics including flavor additives (e.g., menthol), base e-liquid ingredients (propylene glycol, vegetable glycerin), components commonly used to dissolve flavorants (e.g., ethanol), and resulting properties of the e-liquid (e.g., pH), e-cigarette device characteristics (e.g., wattage, temperature, model) and user behavior (e.g., puff topography) which may impact nicotine exposure. E-liquid characteristics and components, e-cigarette hardware and settings, and user behavior can all contribute substantially to nicotine exposure from e

ePerformance: Crafting, Rehearsing, and Presenting the ePortfolio Persona

ERIC Educational Resources Information Center

Ramírez, Kimberly

2011-01-01

"ePerformance: Crafting, Rehearsing, and Presenting the ePortfolio Persona" exposes vital intersections between pedagogy and performance to reveal how using ePortfolio encourages not only student-centered learning, but facilitates collaboration through cooperative exchanges. Productive interactivity with audiences who actively influence…

Toward automated e-cigarette surveillance: Spotting e-cigarette proponents on Twitter.

PubMed

Kavuluru, Ramakanth; Sabbir, A K M

2016-06-01

Electronic cigarettes (e-cigarettes or e-cigs) are a popular emerging tobacco product. Because e-cigs do not generate toxic tobacco combustion products that result from smoking regular cigarettes, they are sometimes perceived and promoted as a less harmful alternative to smoking and also as means to quit smoking. However, the safety of e-cigs and their efficacy in supporting smoking cessation is yet to be determined. Importantly, the federal drug administration (FDA) currently does not regulate e-cigs and as such their manufacturing, marketing, and sale is not subject to the rules that apply to traditional cigarettes. A number of manufacturers, advocates, and e-cig users are actively promoting e-cigs on Twitter. We develop a high accuracy supervised predictive model to automatically identify e-cig "proponents" on Twitter and analyze the quantitative variation of their tweeting behavior along popular themes when compared with other Twitter users (or tweeters). Using a dataset of 1000 independently annotated Twitter profiles by two different annotators, we employed a variety of textual features from latest tweet content and tweeter profile biography to build predictive models to automatically identify proponent tweeters. We used a set of manually curated key phrases to analyze e-cig proponent tweets from a corpus of over one million e-cig tweets along well known e-cig themes and compared the results with those generated by regular tweeters. Our model identifies e-cig proponents with 97% precision, 86% recall, 91% F-score, and 96% overall accuracy, with tight 95% confidence intervals. We find that as opposed to regular tweeters that form over 90% of the dataset, e-cig proponents are a much smaller subset but tweet two to five times more than regular tweeters. Proponents also disproportionately (one to two orders of magnitude more) highlight e-cig flavors, their smoke-free and potential harm reduction aspects, and their claimed use in smoking cessation. Given FDA is

Demystifying LiDAR technologies for temperate rainforest in the Pacific Northwest

Treesearch

Rhonda Mazza; Demetrios Gatziolis

2013-01-01

Light detection and ranging (LiDAR), also known as airborne laser scanning, is a rapidly emerging technology for remote sensing. Used to help map, monitor, and assess natural resources, LiDAR data were first embraced by forestry professionals in Scandinavia as a tool for conducting forest inventories in the mid to late 1990s. Thus early LiDAR theory and applications...

Tree species classification using within crown localization of waveform LiDAR attributes

NASA Astrophysics Data System (ADS)

Blomley, Rosmarie; Hovi, Aarne; Weinmann, Martin; Hinz, Stefan; Korpela, Ilkka; Jutzi, Boris

2017-11-01

Since forest planning is increasingly taking an ecological, diversity-oriented perspective into account, remote sensing technologies are becoming ever more important in assessing existing resources with reduced manual effort. While the light detection and ranging (LiDAR) technology provides a good basis for predictions of tree height and biomass, tree species identification based on this type of data is particularly challenging in structurally heterogeneous forests. In this paper, we analyse existing approaches with respect to the geometrical scale of feature extraction (whole tree, within crown partitions or within laser footprint) and conclude that currently features are always extracted separately from the different scales. Since multi-scale approaches however have proven successful in other applications, we aim to utilize the within-tree-crown distribution of within-footprint signal characteristics as additional features. To do so, a spin image algorithm, originally devised for the extraction of 3D surface features in object recognition, is adapted. This algorithm relies on spinning an image plane around a defined axis, e.g. the tree stem, collecting the number of LiDAR returns or mean values of returns attributes per pixel as respective values. Based on this representation, spin image features are extracted that comprise only those components of highest variability among a given set of library trees. The relative performance and the combined improvement of these spin image features with respect to non-spatial statistical metrics of the waveform (WF) attributes are evaluated for the tree species classification of Scots pine (Pinus sylvestris L.), Norway spruce (Picea abies (L.) Karst.) and Silver/Downy birch (Betula pendula Roth/Betula pubescens Ehrh.) in a boreal forest environment. This evaluation is performed for two WF LiDAR datasets that differ in footprint size, pulse density at ground, laser wavelength and pulse width. Furthermore, we evaluate the

eMedication Meets eHealth with the Electronic Medication Management Assistant (eMMA).

PubMed

Tschanz, Mauro; Dorner, Tim Lucas; Denecke, Kerstin

2017-01-01

A patient's healthcare team is often missing a complete overview on the prescribed and dispensed medication. This is due to an inconsistent information flow between the different actors of the healthcare system. Often, only the patient himself knows exactly which drugs he is actually taking. Our objective is to exploit different eHealth technologies available or planned in Switzerland to improve the information flow of the medication data among the stakeholder and to support the patient in managing his medication. This work is embedded in the "Hospital of the Future Live" project, involving 16 companies and 6 hospitals in order to develop IT solutions for future optimized health care processes. A comprehensive set of requirements was collected from the different actors and project partners. Further, specifications of the available or planned eHealth infrastructure were reviewed to integrate relevant technologies into a coherent concept. We developed a concept that combines the medication list and an eHealth platform. The resulting electronic medication management assistant (eMMA) designed for the patient provides the current medication plan at any time and supports by providing relevant information through a conversational user interface. In Switzerland, we still need a bridging technology to combine the medication information from the electronic patient record with the medication plan's associated QR-Code. The developed app is intended to provide such bridge and demonstrates the usefulness of the eMediplan. It enables the patient to have all data regarding his medication on his personal mobile phone and he can - if necessary - provide the current medication to the health professional.

Review of Heavy Lepton Production in e{sup +}e{sup -} Annihilation

DOE R&D Accomplishments Database

Perl, M. L.

1977-10-01

The existing data on e{sup +-}..mu..{sup -+}, e{sup +-}x{sup -+}, ..mu..{sup +-}x{sup -+}, and related events produced in e{sup +}e{sup -} annihilation are reviewed. All data are consistent with the existence of a new charged lepton, tau{sup +-}, of mass 1.9 +- .1 GeV/c{sup 2}.

A comparison of waveform processing algorithms for single-wavelength LiDAR bathymetry

NASA Astrophysics Data System (ADS)

Wang, Chisheng; Li, Qingquan; Liu, Yanxiong; Wu, Guofeng; Liu, Peng; Ding, Xiaoli

2015-03-01

Due to the low-cost and lightweight units, single-wavelength LiDAR bathymetric systems are an ideal option for shallow-water (<12 m) bathymetry. However, one disadvantage of such systems is the lack of near-infrared and Raman channels, which results in difficulties in extracting the water surface. Therefore, the choice of a suitable waveform processing method is extremely important to guarantee the accuracy of the bathymetric retrieval. In this paper, we test six algorithms for single-wavelength bathymetric waveform processing, i.e. peak detection (PD), the average square difference function (ASDF), Gaussian decomposition (GD), quadrilateral fitting (QF), Richardson-Lucy deconvolution (RLD), and Wiener filter deconvolution (WD). To date, most of these algorithms have previously only been applied in topographic LiDAR waveforms captured over land. A simulated dataset and an Optech Aquarius dataset were used to assess the algorithms, with the focus being on their capability of extracting the depth and the bottom response. The influences of a number of water and equipment parameters were also investigated by the use of a Monte Carlo method. The results showed that the RLD method had a superior performance in terms of a high detection rate and low errors in the retrieved depth and magnitude. The attenuation coefficient, noise level, water depth, and bottom reflectance had significant influences on the measurement error of the retrieved depth, while the effects of scan angle and water surface roughness were not so obvious.

The effect of e-cigarette warning labels on college students' perception of e-cigarettes and intention to use e-cigarettes.

PubMed

Lee, Hsiao-Yun; Lin, Hsien-Chang; Seo, Dong-Chul; Lohrmann, David K

2018-01-01

This study examined the effect of two e-cigarette warning labels on college students' perceived advantages and risks of e-cigarette use, as well as students' intentions to use e-cigarettes. The company-produced e-cigarette warning label carries abundant information with small font size while the governmental warning label has only two sentences presented in large font size. The effect of both labels have not yet been examined and verified. Data were collected in October 2015 from college students at a Midwestern university. A pretest-posttest design was employed with 338 students exposed to the warning label proposed by the FDA and 328 students exposed to the label created by e-cigarette companies. Structural equation modeling analysis was implemented to examine the effect of warning labels with the analytical model grounded in the Theory of Planned Behavior. Findings showed that college students' perceived advantages of e-cigarette use were positively related to their intentions to use e-cigarettes, while perceived risks were negatively associated with their intentions. When comparing two labels, the governmental label was found to reduce college students' intentions to use e-cigarettes via increasing perceived risks of e-cigarette use (β=0.10, p<0.05), however, not via decreasing perceived advantages of e-cigarette use. The warning label currently used by e-cigarette companies showed no influence on beliefs about or intentions to use e-cigarettes. The warning label proposed by the FDA is more effective than that created by e-cigarette companies, however, has room for improvement to make a greater impact on e-cigarette use intention. Copyright © 2017 Elsevier Ltd. All rights reserved.

The application of LiDAR to investigate foredune morphology and vegetation

NASA Astrophysics Data System (ADS)

Doyle, Thomas B.; Woodroffe, Colin D.

2018-02-01

LiDAR (Light Detection and Ranging) has been used to investigate coastal landform morphology, evolution, and change for almost a decade. Repeated airborne LiDAR surveys can provide the scientific community with significant observations of how shorelines have evolved, which may then enable forecasts of future patterns of change. However, there have been few studies that have considered the application of this new technology to the specific study of foredune morphology and vegetation. The accuracy and appropriateness of airborne LiDAR needs to be assessed, particularly where the density of vegetation may obscure the underlying topography, prior to interpreting derived geomorphic features. This study: i) tests the vertical accuracy of airborne LiDAR in 37 foredune systems along the coast of south-eastern Australia, and ii) demonstrates that it can be used to describe foredune morphology and vegetation in considerable detail. There was a strong correlation between the remotely-sensed LiDAR-derived elevation and field topographic and vegetation surveys (R2 = 0.96). A protocol for obtaining foredune geomorphic and botanical parameters is described. It enables widespread biogeomorphic characterisation along coasts for which LiDAR data is available, which can benefit both coastal managers and researchers alike.

Quality of e-Learning: An Analysis Based on e-Learners' Perception of e-Learning

ERIC Educational Resources Information Center

Elango, Rengasamy; Gudep, Vijaya Kumar; Selvam, M.

2008-01-01

e-Learning, of late, has been witnessing an unprecedented expansion as an opportunity for higher education. This expanding alternative mode calls for ensuring and imparting a sound and qualitative education. The present study made an attempt to investigate the issues related to the quality dimensions of e-learning. Our results revealed the…

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

PubMed Central

Mulder, Monique P.C.; Witting, Katharina; Berlin, Ilana; Pruneda, Jonathan N.; Wu, Kuen-Phon; Chang, Jer-Gung; Merkx, Remco; Bialas, Johanna; Groettrup, Marcus; Vertegaal, Alfred C.O.; Schulman, Brenda A.; Komander, David; Neefjes, Jacques; Oualid, Farid El; Ovaa, Huib

2016-01-01

Post-translational modifications of proteins with ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers, orchestrated by a cascade of specialized E1, E2 and E3 enzymes, control a staggering breadth of cellular processes. To monitor catalysis along these complex reaction pathways, we developed a cascading activity-based probe, UbDha. Akin to the native Ub, upon ATP-dependent activation by the E1, UbDha can travel downstream to the E2 (and subsequently E3) enzymes through sequential trans-thioesterifications. Unlike the native Ub, at each step along the cascade UbDha has the option to react irreversibly with active site cysteine residues of target enzymes, thus enabling their detection. We show that our cascading probe ‘hops’ and ‘traps’ catalytically active ubiquitin-modifying enzymes (but not their substrates) by a mechanism diversifiable to Ubls. Our founder methodology, amenable to structural studies, proteome-wide profiling and monitoring of enzymatic activities in living cells, presents novel and versatile tools to interrogate the Ub/Ubl cascades. PMID:27182664

Autism-related deficits via dysregulated eIF4E-dependent translational control.

PubMed

Gkogkas, Christos G; Khoutorsky, Arkady; Ran, Israeli; Rampakakis, Emmanouil; Nevarko, Tatiana; Weatherill, Daniel B; Vasuta, Cristina; Yee, Stephanie; Truitt, Morgan; Dallaire, Paul; Major, François; Lasko, Paul; Ruggero, Davide; Nader, Karim; Lacaille, Jean-Claude; Sonenberg, Nahum

2013-01-17

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is strongly implicated in ASDs by means of upstream signalling; however, downstream regulatory mechanisms are ill-defined. Here we show that knockout of the eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2)-an eIF4E repressor downstream of mTOR-or eIF4E overexpression leads to increased translation of neuroligins, which are postsynaptic proteins that are causally linked to ASDs. Mice that have the gene encoding 4E-BP2 (Eif4ebp2) knocked out exhibit an increased ratio of excitatory to inhibitory synaptic inputs and autistic-like behaviours (that is, social interaction deficits, altered communication and repetitive/stereotyped behaviours). Pharmacological inhibition of eIF4E activity or normalization of neuroligin 1, but not neuroligin 2, protein levels restores the normal excitation/inhibition ratio and rectifies the social behaviour deficits. Thus, translational control by eIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders ASD-like phenotypes.

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

PubMed Central

Ilgü, Hüseyin; Jeckelmann, Jean-Marc; Colas, Claire; Ucurum, Zöhre; Schlessinger, Avner; Fotiadis, Dimitrios

2018-01-01

The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from Escherichia coli, as well as its previously reported point mutants N22A and S26A, were overexpressed homologously and purified to homogeneity. A size-exclusion chromatography-based thermostability assay was used to determine the melting temperatures (Tms) of the purified AdiC variants in the absence and presence of the selected ligands l-arginine (Arg), agmatine, l-arginine methyl ester, and l-arginine amide. The resulting Tms indicated stabilization of AdiC variants upon ligand binding, in which Tms and ligand binding affinities correlated positively. Considering results from this and previous studies, we revisited the role of AdiC residue S26 in Arg binding and proposed interactions of the α-carboxylate group of Arg exclusively with amide groups of the AdiC backbone. In the context of substrate binding in the human SLC7 family member l-type amino acid transporter-1 (LAT1; SLC7A5), an analogous role of S66 in LAT1 to S26 in AdiC is discussed based on homology modeling and amino acid sequence analysis. Finally, we propose a binding mechanism for l-amino acid substrates to LATs from the SLC7 family. PMID:29558430

Mining online e-liquid reviews for opinion polarities about e-liquid features.

PubMed

Chen, Zhipeng; Zeng, Daniel D

2017-07-07

In recent years, the emerging electronic cigarette (e-cigarette) marketplace has developed prosperously all over the world. By analyzing online e-liquid reviews, we seek to identify the features attracting users. We collected e-liquid reviews from one of the largest online e-liquid review websites and extracted the e-liquid features by keywords. Then we used sentiment analysis to classify the features into two polarities: positive and negative. The positive sentiment ratio of a feature reflects the e-cigarette users' preference on this feature. The popularity and preference of e-liquid features are not correlated. Nuts and cream are the favorite flavor categories, while fruit and cream are the most popular categories. The top mixed flavors are preferable to single flavors. Fruit and cream categories are most frequently mixed with other flavors. E-cigarette users are satisfied with cloud production, but not satisfied with the ingredients and throat hit. We identified the flavors that e-cigarette users were satisfied with, and we found the users liked e-cigarette cloud production. Therefore, flavors and cloud production are potential factors attracting new users.

Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs.

PubMed

Ham, Jong Hyun; Majerczak, Doris R; Nomura, Kinya; Mecey, Christy; Uribe, Francisco; He, Sheng-Yang; Mackey, David; Coplin, David L

2009-06-01

The broadly conserved AvrE-family of type III effectors from gram-negative plant-pathogenic bacteria includes important virulence factors, yet little is known about the mechanisms by which these effectors function inside plant cells to promote disease. We have identified two conserved motifs in AvrE-family effectors: a WxxxE motif and a putative C-terminal endoplasmic reticulum membrane retention/retrieval signal (ERMRS). The WxxxE and ERMRS motifs are both required for the virulence activities of WtsE and AvrE, which are major virulence factors of the corn pathogen Pantoea stewartii subsp. stewartii and the tomato or Arabidopsis pathogen Pseudomonas syringae pv. tomato, respectively. The WxxxE and the predicted ERMRS motifs are also required for other biological activities of WtsE, including elicitation of the hypersensitive response in nonhost plants and suppression of defense responses in Arabidopsis. A family of type III effectors from mammalian bacterial pathogens requires WxxxE and subcellular targeting motifs for virulence functions that involve their ability to mimic activated G-proteins. The conservation of related motifs and their necessity for the function of type III effectors from plant pathogens indicates that disturbing host pathways by mimicking activated host G-proteins may be a virulence mechanism employed by plant pathogens as well.

Divergent Synthesis of Revised Apratoxin E, 30-epi-Apratoxin E, and 30S/30R-Oxoapratoxin E.

PubMed

Mao, Zhuo-Ya; Si, Chang-Mei; Liu, Yi-Wen; Dong, Han-Qing; Wei, Bang-Guo; Lin, Guo-Qiang

2017-10-20

In this report, originally proposed apratoxin E (30S-7), revised apratoxin E (30R-7), and (30S)/(30R)-oxoapratoxin E (30S)-38/(30R)-38 were efficiently prepared by two synthetic methods. The chiral lactone 10, recycled from the degradation of saponin glycosides, was utilized to prepare the key nonpeptide fragment 9. Our alternative convergent assembly strategy was applied to the divergent synthesis of revised apratoxin E and its three analogues. Moreover, ring-closing metathesis (RCM) was for the first time found to be an efficient strategy for the macrocyclization of apratoxins.

Emissions & Generation Resource Integrated Database (eGRID), eGRID2010

EPA Pesticide Factsheets

The Emissions & Generation Resource Integrated Database (eGRID) is a comprehensive source of data on the environmental characteristics of almost all electric power generated in the United States. These environmental characteristics include air emissions for nitrogen oxides, sulfur dioxide, carbon dioxide, methane, and nitrous oxide; emissions rates; net generation; resource mix; and many other attributes.eGRID2010 contains the complete release of year 2007 data, as well as years 2005 and 2004 data. Excel spreadsheets, full documentation, summary data, eGRID subregion and NERC region representational maps, and GHG emission factors are included in this data set. The Archived data in eGRID2002 contain years 1996 through 2000 data.For year 2007 data, the first Microsoft Excel workbook, Plant, contains boiler, generator, and plant spreadsheets. The second Microsoft Excel workbook, Aggregation, contains aggregated data by state, electric generating company, parent company, power control area, eGRID subregion, NERC region, and U.S. total levels. The third Microsoft Excel workbook, ImportExport, contains state import-export data, as well as U.S. generation and consumption data for years 2007, 2005, and 2004. For eGRID data for years 2005 and 2004, a user friendly web application, eGRIDweb, is available to select, view, print, and export specified data.

Vitamin E

MedlinePlus

... extra vitamin E. Vitamin E supplements may be harmful for people who take blood thinners and other medicines. Check with your health care provider before taking the supplements. NIH: National Institutes of Health Office of Dietary Supplements

Behavior of the E-E' Bonds (E, E' = S and Se) in Glutathione Disulfide and Derivatives Elucidated by Quantum Chemical Calculations with the Quantum Theory of Atoms-in-Molecules Approach.

PubMed

Hayashi, Satoko; Tsubomoto, Yutaka; Nakanishi, Waro

2018-02-17

The nature of the E-E' bonds (E, E' = S and Se) in glutathione disulfide ( 1 ) and derivatives 2 - 3 , respectively, was elucidated by applying quantum theory of atoms-in-molecules (QTAIM) dual functional analysis (QTAIM-DFA), to clarify the basic contribution of E-E' in the biological redox process, such as the glutathione peroxidase process. Five most stable conformers a - e were obtained, after applying the Monte-Carlo method then structural optimizations. In QTAIM-DFA, total electron energy densities H b ( r c ) are plotted versus H b ( r c ) - V b ( r c )/2 at bond critical points (BCPs), where V b ( r c ) are potential energy densities at BCPs. Data from the fully optimized structures correspond to the static nature. Those containing perturbed structures around the fully optimized one in the plot represent the dynamic nature of interactions. The behavior of E-E' was examined carefully. Whereas E-E' in 1a - 3e were all predicted to have the weak covalent nature of the shared shell interactions, two different types of S-S were detected in 1 , depending on the conformational properties. Contributions from the intramolecular non-covalent interactions to stabilize the conformers were evaluated. An inverse relationship was observed between the stability of a conformer and the strength of E-E' in the conformer, of which reason was discussed.

Identifying slow-moving landslides using LiDAR DEM and SAR interferometry: An Example of 2006 Meinong Earthquake

NASA Astrophysics Data System (ADS)

Chen, R. F.; Lin, C. W.; Hsu, Y. J.; Zhang, L.; Liang, H. Y.

2017-12-01

The February 6 Meinong Earthquake of 2016 (ML=6.4; at 23.85ºN, 120.81ºE), with a focal depth of 16.7 km, was triggered by an unknown blind thrust in southern Taiwan. The earthquake not only induced coseismic crustal deformation, but also triggered slow-moving landslides nearby the Longchuan active fault. In this study, high-resolution LiDAR derived DEM of 2010 is used to recognize locations of previous slow-moving landslides according to their topographic signatures, such as main escarpment, trench, double ridge, and crown cracks. Within an area of 4.5 km x 1.8 km along Longchuan fault near the ridge of Longchuan mountain, over 50 sites with landslide signatures are recognized, and three of them are over 10 ha. These earthquake-induced landslide deformations are detected from InSAR (synthetic aperture radar interferometry) images using Advanced Land Observing Satellite ALOS2/Phased-array L band and Sentinel 1 C-band SAR (PALSAR) data taken before and after the earthquake; some significant landslide deformation are even overlapped with areas where previous slow moving landslides were identified on the LiDAR DEM. Additionally, field investigation right after the earthquake in the study area also support that these previously identified landslides reactivated in the earthquake. Although these landslides do not cause serious damage due to their minor displacement in the Meinong Earthquake, the study results prove that LiDAR DEM is a powerful tool to identify and continuously monitor slow-motion landslides for preventing catastrophic failures that may be caused by hazardous earthquake or heavy rainfall.

Visualization of High-Resolution LiDAR Topography in Google Earth

NASA Astrophysics Data System (ADS)

Crosby, C. J.; Nandigam, V.; Arrowsmith, R.; Blair, J. L.

2009-12-01

The growing availability of high-resolution LiDAR (Light Detection And Ranging) topographic data has proven to be revolutionary for Earth science research. These data allow scientists to study the processes acting on the Earth’s surfaces at resolutions not previously possible yet essential for their appropriate representation. In addition to their utility for research, the data have also been recognized as powerful tools for communicating earth science concepts for education and outreach purposes. Unfortunately, the massive volume of data produced by LiDAR mapping technology can be a barrier to their use. To facilitate access to these powerful data for research and educational purposes, we have been exploring the use of Keyhole Markup Language (KML) and Google Earth to deliver LiDAR-derived visualizations. The OpenTopography Portal (http://www.opentopography.org/) is a National Science Foundation-funded facility designed to provide access to Earth science-oriented LiDAR data. OpenTopography hosts a growing collection of LiDAR data for a variety of geologic domains, including many of the active faults in the western United States. We have found that the wide spectrum of LiDAR users have variable scientific applications, computing resources, and technical experience and thus require a data distribution system that provides various levels of access to the data. For users seeking a synoptic view of the data, and for education and outreach purposes, delivering full-resolution images derived from LiDAR topography into the Google Earth virtual globe is powerful. The virtual globe environment provides a freely available and easily navigated viewer and enables quick integration of the LiDAR visualizations with imagery, geographic layers, and other relevant data available in KML format. Through region-dependant network linked KML, OpenTopography currently delivers over 20 GB of LiDAR-derived imagery to users via simple, easily downloaded KMZ files hosted at the Portal

Evaluation of LiDAR Imagery as a Tool for Mapping the Northern San Andreas Fault in Heavily Forested Areas of Mendocino and Sonoma Counties, California

NASA Astrophysics Data System (ADS)

Prentice, C. S.; Koehler, R. D.; Baldwin, J. N.; Harding, D. J.

2004-12-01

We are mapping in detail active traces of the San Andreas Fault in Mendocino and Sonoma Counties in northern California, using recently acquired airborne LiDAR (also known as ALSM) data. The LiDAR data set provides a powerful new tool for mapping geomorphic features related to the San Andreas Fault because it can be used to produce high-resolution images of the ground surfaces beneath the forest canopy along the 70-km-long section of the fault zone encompassed by the data. Our effort represents the first use of LiDAR data to map active fault traces in a densely vegetated region along the San Andreas Fault. We are using shaded relief images generated from bare-earth DEMs to conduct detailed mapping of fault-related geomorphic features (e.g. scarps, offset streams, linear valleys, shutter ridges, and sag ponds) between Fort Ross and Point Arena. Initially, we map fault traces digitally, on-screen, based only on the geomorphology interpreted from LiDAR images. We then conduct field reconnaissance using the initial computer-based maps in order to verify and further refine our mapping. We found that field reconnaissance is of utmost importance in producing an accurate and detailed map of fault traces. Many lineaments identified as faults from the on-screen images were determined in the field to be old logging roads or other features unrelated to faulting. Also, in areas where the resolution of LiDAR data is poor, field reconnaissance, coupled with topographic maps and aerial photographs, permits a more accurate location of fault-related geomorphic features. LiDAR images are extremely valuable as a base for field mapping in this heavily forested area, and the use of LiDAR is far superior to traditional mapping techniques relying only on aerial photography and 7.5 minute USGS quadrangle topographic maps. Comparison with earlier mapping of the northern San Andreas fault (Brown and Wolfe, 1972) shows that in some areas the LiDAR data allow a correction of the fault trace

Molecular and Cytological Comparisons of Chromosomes 7el₁, 7el₂, 7E(e), and 7E ⁱ Derived from Thinopyrum.

PubMed

Guo, Jun; He, Fang; Cai, Jin-Jin; Wang, Hong-Wei; Li, An-Fei; Wang, Hong-Gang; Kong, Ling-Rang

2015-01-01

Thinopyrum chromosomes 7el1, 7el2, 7E(e), and 7E(i), homoeologous to group 7 chromosomes of common wheat (Triticum aestivum), were determined to have many useful agronomical traits for wheat improvement. To analyze the genetic relationships among the 4 Thinopyrum 7E chromosomes, the conserved orthologous set markers, genomic in situ hybridization (GISH), and meiotic chromosome pairing were used in this study. The unweighted pair-group method with arithmetical averages (UPGMA) analysis indicated that 7el1, derived from T. ponticum, and 7E(i), derived from T. intermedium, were the most closely related. 7el2, derived from T. ponticum, was relatively distant from the 7el1-7E(i) complex. While 7E(e), derived from T. elongatum, was more distantly related to 7el1, 7el2, and 7E(i). This is the first report showing that 7el1 and 7E(i) may be similar, which could be explained by the similar chromosome signal distribution revealed by GISH as well as UPGMA analysis revealed by both molecular markers and the highest frequency of meiotic pairing. The newly developed genome-specific molecular markers may be useful for marker-assisted selection of Lr19, Bdv3, and Fhblop. © 2015 S. Karger AG, Basel.

e-Manifest

EPA Pesticide Factsheets

This is the primary hub for those seeking information about the e-Manifest system, its advisory board, and its development. Once the system is complete this area will serve as the portal into the e-Manifest system from EPA webpages.

E. Coli

MedlinePlus

... common type of bacteria that can get into food, like beef and vegetables. E. coli is short for the ... in fresh spinach in 2006 and some fast-food hamburgers in 1993. Beef can contain E. coli because the bacteria often ...

DEPFET pixel detector for future e-e+ experiments

NASA Astrophysics Data System (ADS)

Boronat, M.; DEPFET Collaboration

2016-04-01

The DEPFET Collaboration develops highly granular, ultra-thin pixel detectors for outstanding vertex reconstruction at future e+e- collider experiments. A DEPFET sensor provides, simultaneously, position sensitive detector capabilities and in-pixel amplification by the integration of a field effect transistor on a fully depleted silicon bulk. The characterization of the latest DEPFET prototypes has proven that a comfortable signal to noise ratio and excellent single point resolution can be achieved for a sensor thickness of 50 μm. A complete detector concept is being developed for the Belle II experiment at the new Japanese super flavor factory. The close to Belle related final auxiliary ASICs have been produced and found to operate a DEPFET pixel detector of the latest generation with the Belle II required read-out speed. DEPFET is not only the technology of choice for the Belle II vertex detector, but also a solid candidate for the International Linear Collider (ILC). Therefore, in this paper, the status of DEPFET R&D project is reviewed in the light of the requirements of the vertex detector at a future e+e- collider.

Important LiDAR metrics for discriminating forest tree species in Central Europe

NASA Astrophysics Data System (ADS)

Shi, Yifang; Wang, Tiejun; Skidmore, Andrew K.; Heurich, Marco

2018-03-01

Numerous airborne LiDAR-derived metrics have been proposed for classifying tree species. Yet an in-depth ecological and biological understanding of the significance of these metrics for tree species mapping remains largely unexplored. In this paper, we evaluated the performance of 37 frequently used LiDAR metrics derived under leaf-on and leaf-off conditions, respectively, for discriminating six different tree species in a natural forest in Germany. We firstly assessed the correlation between these metrics. Then we applied a Random Forest algorithm to classify the tree species and evaluated the importance of the LiDAR metrics. Finally, we identified the most important LiDAR metrics and tested their robustness and transferability. Our results indicated that about 60% of LiDAR metrics were highly correlated to each other (|r| > 0.7). There was no statistically significant difference in tree species mapping accuracy between the use of leaf-on and leaf-off LiDAR metrics. However, combining leaf-on and leaf-off LiDAR metrics significantly increased the overall accuracy from 58.2% (leaf-on) and 62.0% (leaf-off) to 66.5% as well as the kappa coefficient from 0.47 (leaf-on) and 0.51 (leaf-off) to 0.58. Radiometric features, especially intensity related metrics, provided more consistent and significant contributions than geometric features for tree species discrimination. Specifically, the mean intensity of first-or-single returns as well as the mean value of echo width were identified as the most robust LiDAR metrics for tree species discrimination. These results indicate that metrics derived from airborne LiDAR data, especially radiometric metrics, can aid in discriminating tree species in a mixed temperate forest, and represent candidate metrics for tree species classification and monitoring in Central Europe.

Diversity Arrays Technology (DArT) for whole-genome profiling of barley

PubMed Central

Wenzl, Peter; Carling, Jason; Kudrna, David; Jaccoud, Damian; Huttner, Eric; Kleinhofs, Andris; Kilian, Andrzej

2004-01-01

Diversity Arrays Technology (DArT) can detect and type DNA variation at several hundred genomic loci in parallel without relying on sequence information. Here we show that it can be effectively applied to genetic mapping and diversity analyses of barley, a species with a 5,000-Mbp genome. We tested several complexity reduction methods and selected two that generated the most polymorphic genomic representations. Arrays containing individual fragments from these representations generated DArT fingerprints with a genotype call rate of 98.0% and a scoring reproducibility of at least 99.8%. The fingerprints grouped barley lines according to known genetic relationships. To validate the Mendelian behavior of DArT markers, we constructed a genetic map for a cross between cultivars Steptoe and Morex. Nearly all polymorphic array features could be incorporated into one of seven linkage groups (98.8%). The resulting map comprised ≈385 unique DArT markers and spanned 1,137 centimorgans. A comparison with the restriction fragment length polymorphism-based framework map indicated that the quality of the DArT map was equivalent, if not superior, to that of the framework map. These results highlight the potential of DArT as a generic technique for genome profiling in the context of molecular breeding and genomics. PMID:15192146

The impact of tissue Doppler index E/e' ratio on instantaneous wave-free ratio.

PubMed

Arashi, Hiroyuki; Yamaguchi, Junichi; Ri, Tonre; Otsuki, Hisao; Nakao, Masashi; Kamishima, Kazuho; Jujo, Kentaro; Minami, Yuichiro; Ogawa, Hiroshi; Hagiwara, Nobuhisa

2018-03-01

The instantaneous wave-free ratio (iFR) is a vasodilator-free, invasive pressure wire index of the functional severity of coronary stenosis and is calculated under resting conditions. In a recent study, iFR was found to be more closely linked to coronary flow reserve (CFR) than fractional flow reserve (FFR). E/e' is a surrogate marker of left ventricular (LV) filling pressure and LV diastolic dysfunction. Coronary resting flow was found to be increased in patients with elevated E/e', and higher coronary resting flow was associated with lower CFR. Higher baseline coronary flow induces a greater loss of translesional pressure and may affect iFR. However, no reports have examined the impact of E/e' on iFR. The purpose of this study was to assess the relationship between iFR and E/e' compared with FFR. We retrospectively examined 103 consecutive patients (142 with stenosis) whose iFR, FFR, and E/e' were measured simultaneously. The mean age, LV mass index, and systolic blood pressure of patients with elevated E/e' were higher than those of patients with normal E/e'. Although no significant differences were observed in mean FFR values and % diameter stenosis, the mean iFR value in patients with elevated E/e' was significantly lower than that in patients with normal E/e'. The iFR was negatively correlated with E/e', while there was no correlation between FFR and E/e'. Multivariate analysis showed that E/e' and % diameter stenosis were independent determinants of iFR. E/e' ratio affects iFR values. Our results suggest that FFR mainly reflects the functional severity of the epicardial stenosis whereas iFR could potentially be influenced by not only epicardial stenosis but also other factors related to LV filling pressure or LV diastolic dysfunction. Further research is needed to understand the underlying mechanisms that influence the evaluation of iFR in patients with elevated E/e'. Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights

Quasifree (e,e'p) reaction on /sup 3/He

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jans, E.; Barreau, P.; Bernheim, M.

1982-10-04

The proton momentum distribution of /sup 3/He has been determined up to momenta of 310 MeV/c by use of the reaction /sup 3/He(e,e'p). The experimental missing energy resolution, deltaE/sub m/ = 1.2 MeV, was sufficient to separate the two- and three-body breakup channels. Results for the three-body disintegration have been obtained up to missing energy values of 80 MeV. The resulting spectral function is compared with the predictions of Faddeev and variational calculations.

E-Cigarette Toxicity?

PubMed

Tegin, Gulay; Mekala, Hema Madhuri; Sarai, Simrat Kaur; Lippmann, Steven

2018-01-01

Tobacco smoking is the most preventable cause of morbidity and mortality. In just a few short years, electronic cigarettes (e-cigarettes) have become increasingly popular, especially for younger individuals. Many people believe that e-cigarettes are safe. The inhaled aerosols of e-cigarettes contain numerous potential toxicities, some of which could be dangerous for health with long-term use. The safety of prolonged aerosol exposure is not known. The use of e-cigarettes as a harm-reduction tool at stopping tobacco smoking is not uniformly successful. E-cigarettes may be safer than tobacco products, but repeated prolonged exposure to their aerosols has its own considerable potential risk. The long-term health consequences of their use remain to be established. Physicians should vigorously discourage the use of e-cigarettes and tobacco products, with special emphasis on abstinence for younger people and during pregnancy or lactation.

Assessing LiDAR elevation data for KDOT applications : [technical summary].

DOT National Transportation Integrated Search

2013-02-01

LiDAR-based elevation surveys : are a cost-effective means for : mapping topography over large : areas. LiDAR surveys use an : airplane-mounted or ground-based : laser radar unit to scan terrain. : Post-processing techniques are : applied to remove v...

E-cigarette advertising exposure in e-cigarette naïve adolescents and subsequent e-cigarette use: A longitudinal cohort study.

PubMed

Camenga, Deepa; Gutierrez, Kevin M; Kong, Grace; Cavallo, Dana; Simon, Patricia; Krishnan-Sarin, Suchitra

2018-06-01

Electronic (E-) cigarettes are one of the most popular tobacco products used by adolescents today. This study examined whether exposure to advertisements in (1) social networking sites (Facebook, Twitter, YouTube, Pinterest/Google Plus), (2) traditional media (television/radio, magazines, billboards), or (3) retail stores (convenience stores, mall kiosks, tobacco shops) was associated with subsequent e-cigarette use in a longitudinal cohort of adolescents. Data were drawn from longitudinal surveys conducted in fall 2013 (wave 1) and spring 2014 (wave 2) of a school-based cohort attending 3 high schools and 2 middle schools in Connecticut. Adolescents were asked about tobacco use behaviors and where they had recently seen e-cigarette advertising at wave 1. We used logistic regression to determine whether advertising exposure at wave 1 increased the odds of e-cigarette use by wave 2, controlling for demographics and cigarette smoking status at wave 1. Among those who have never used e-cigarettes in wave 1 (n = 1742), 9.6% reported e-cigarette use at wave 2. Multivariate logistic regression demonstrated that exposure to e-cigarette advertising on Facebook (OR 2.12 = p < 0.02) at wave 1, but not other venues, significantly increased the odds of subsequent e-cigarette use wave 2. Age, white race, and cigarette smoking at wave 1 also was associated with e-cigarette use at wave 2. This study provides one of the first longitudinal examinations demonstrating that exposure to e-cigarette advertising on social networking sites among youth who had never used e-cigarettes increases the likelihood of subsequent e-cigarette use. Copyright © 2018 Elsevier Ltd. All rights reserved.

E-Fundi as a Viable Way to Do E-Mentoring

ERIC Educational Resources Information Center

Lotter, George A.

2015-01-01

This paper describes E-fundi as a learning management system developed for the now more than 65,000 students of by the North-West University in South Africa. In this paper, it will be proposed that e-mentoring as a recent development of traditional mentoring, may be pursued by way of E-fundi to the enrichment and growth of students wherever they…

Crystal structure of a minimal eIF4E–Cup complex reveals a general mechanism of eIF4E regulation in translational repression

PubMed Central

Kinkelin, Kerstin; Veith, Katharina; Grünwald, Marlene; Bono, Fulvia

2012-01-01

Cup is an eIF4E-binding protein (4E-BP) that plays a central role in translational regulation of localized mRNAs during early Drosophila development. In particular, Cup is required for repressing translation of the maternally contributed oskar, nanos, and gurken mRNAs, all of which are essential for embryonic body axis determination. Here, we present the 2.8 Å resolution crystal structure of a minimal eIF4E–Cup assembly, consisting of the interacting regions of the two proteins. In the structure, two separate segments of Cup contact two orthogonal faces of eIF4E. The eIF4E-binding consensus motif of Cup (YXXXXLΦ) binds the convex side of eIF4E similarly to the consensus of other eIF4E-binding proteins, such as 4E-BPs and eIF4G. The second, noncanonical, eIF4E-binding site of Cup binds laterally and perpendicularly to the eIF4E β-sheet. Mutations of Cup at this binding site were shown to reduce binding to eIF4E and to promote the destabilization of the associated mRNA. Comparison with the binding mode of eIF4G to eIF4E suggests that Cup and eIF4G binding would be mutually exclusive at both binding sites. This shows how a common molecular surface of eIF4E might recognize different proteins acting at different times in the same pathway. The structure provides insight into the mechanism by which Cup disrupts eIF4E–eIF4G interaction and has broader implications for understanding the role of 4E-BPs in translational regulation. PMID:22832024

Investigation of beam self-polarization in the future e+e- circular collider

NASA Astrophysics Data System (ADS)

Gianfelice-Wendt, E.

2016-10-01

The use of resonant depolarization has been suggested for precise beam energy measurements (better than 100 keV) in the e+e- Future Circular Collider (FCC-e+e-) for Z and W W physics at 45 and 80 GeV beam energy respectively. Longitudinal beam polarization would benefit the Z peak physics program; however it is not essential and therefore it will be not investigated here. In this paper the possibility of self-polarized leptons is considered. Preliminary results of simulations in presence of quadrupole misalignments and beam position monitors (BPMs) errors for a simplified FCC-e+e- ring are presented.

Evidence for the decay D0-->K(-)pi(+)pi(-)e(+)nu(e).

PubMed

Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Naik, P; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Potlia, V; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Ernst, J; Ecklund, K M; Severini, H; Love, W; Savinov, V; Aquines, O; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F

2007-11-09

Using a 281 pb{-1} data sample collected at the psi(3770) with the CLEO-c detector, we present the first absolute branching fraction measurement of the decay D0-->K(-)pi(+)pi(-)e(+)nu(e) at a statistical significance of about 4.0 standard deviations. We find 10 candidates consistent with the decay D0-->K(-)pi(+)pi(-)e(+)nu(e). The probability that a background fluctuation accounts for this signal is less than 4.1 x 10{-5}. We find B(D0-->K(-)pi(+)pi(-)e(+)nu(e)) = [2.8{-1.1}{+1.4}(stat)+/-0.3(syst)]x10{-4}. By restricting the invariant mass of the hadronic system to be consistent with K1(1270), we obtain the product of branching fractions B(D{0}-->K{1}{-}(1270)e{+}nu{e})xB(K1-(1270)-->K{-}pi{+}pi{-})=[2.5{-1.0}{+1.3}(stat)+/-0.2(syst)]x10{-4}. Using B(K1-(1270)-->K{-}pi{+}pi{-})=(33+/-3)%, we obtain B(D{0}-->K{1}{-}(1270)e{+}nu{e})=[7.6{-3.0}{+4.1}(stat)+/-0.6(syst)+/-0.7]x10{-4}. The last error accounts for the uncertainties in the measured K1-(1270)-->K{-}pi{+}pi{-} branching fractions.

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters.

PubMed

Ilgü, Hüseyin; Jeckelmann, Jean-Marc; Colas, Claire; Ucurum, Zöhre; Schlessinger, Avner; Fotiadis, Dimitrios

2018-03-20

The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from Escherichia coli, as well as its previously reported point mutants N22A and S26A, were overexpressed homologously and purified to homogeneity. A size-exclusion chromatography-based thermostability assay was used to determine the melting temperatures ( T m s) of the purified AdiC variants in the absence and presence of the selected ligands l-arginine (Arg), agmatine, l-arginine methyl ester, and l-arginine amide. The resulting T m s indicated stabilization of AdiC variants upon ligand binding, in which T m s and ligand binding affinities correlated positively. Considering results from this and previous studies, we revisited the role of AdiC residue S26 in Arg binding and proposed interactions of the α-carboxylate group of Arg exclusively with amide groups of the AdiC backbone. In the context of substrate binding in the human SLC7 family member l-type amino acid transporter-1 (LAT1; SLC7A5), an analogous role of S66 in LAT1 to S26 in AdiC is discussed based on homology modeling and amino acid sequence analysis. Finally, we propose a binding mechanism for l-amino acid substrates to LATs from the SLC7 family.

LiDAR error estimation with WAsP engineering

NASA Astrophysics Data System (ADS)

Bingöl, F.; Mann, J.; Foussekis, D.

2008-05-01

The LiDAR measurements, vertical wind profile in any height between 10 to 150m, are based on assumption that the measured wind is a product of a homogenous wind. In reality there are many factors affecting the wind on each measurement point which the terrain plays the main role. To model LiDAR measurements and predict possible error in different wind directions for a certain terrain we have analyzed two experiment data sets from Greece. In both sites LiDAR and met, mast data have been collected and the same conditions are simulated with RisØ/DTU software, WAsP Engineering 2.0. Finally measurement data is compared with the model results. The model results are acceptable and very close for one site while the more complex one is returning higher errors at higher positions and in some wind directions.

Cholinesterase (ChE) response and related mortality among birds fed ChE inhibitors

USGS Publications Warehouse

Ludke, J.L.; Hill, E.F.; Dieter, M.P.

1975-01-01

Patterns of mortality and inhibition of brain and plasma ChE in birds treated with ChE inhibitors were studied in an attempt to determine the validity of using ChE activity as a monitoring and diagnostic technique. Analysis of brain ChE activity proved to be reliable for diagnosing and monitoring effects of selected ChE inhibitors in birds. Brain ChE inhibition exceeding 20% indicated exposure, and inhibition greater than 50% was sufficient for diagnosing cause of death. Individuals that died from dietary exposure to parathion or carbofuran had brain ChE activities below 55% of normal; although individuals could survive with brain ChE activity lower than 50%. Problems associated with collection, storage, and analysis of tissues for ChE activity are discussed.

E-Cigarette Marketing Exposure Is Associated With E-Cigarette Use Among US Youth.

PubMed

Mantey, Dale S; Cooper, Maria R; Clendennen, Stephanie L; Pasch, Keryn E; Perry, Cheryl L

2016-06-01

E-cigarettes are currently the most commonly used tobacco product among US youth. However, unlike conventional cigarettes, e-cigarettes are not subject to marketing restrictions. This study investigates the association between exposure to e-cigarette marketing and susceptibility and use of e-cigarettes in youth. Data were obtained from the 2014 National Youth Tobacco Survey. Participants were 22,007 US middle and high school students. Multivariate logistic regression models assessed the relationship between e-cigarette marketing (internet, print, retail, and TV/movies) and current and ever use as well as susceptibility to use e-cigarettes among never e-cigarette users. Exposure to each type of e-cigarette marketing was significantly associated with increased likelihood of ever and current use of e-cigarettes among middle and high school students. Exposure was also associated with susceptibility to use of e-cigarettes among current nonusers. In multivariate models, as the number of channels of e-cigarette marketing exposure increased, the likelihood of use and susceptibility also increased. Findings highlight the significant associations between e-cigarette marketing and e-cigarette use among youth and the need for longitudinal research on these relationships. Copyright © 2016 The Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

E. Coli Infections

MedlinePlus

E. coli is the name of a type of bacteria that lives in your intestines. Most types of E. coli are harmless. However, some types can make you ... type causes travelers' diarrhea. The worst type of E. coli causes bloody diarrhea, and can sometimes cause kidney ...

Measurement of the Higgs boson mass and e + e - → Z H cross section using Z → μ + μ - and Z → e + e - at the ILC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, J.; Watanuki, S.; Fujii, K.

This paper presents a full simulation study of the measurement of the production cross section(ZH) of the Higgsstrahlung process e+e- ZH and the Higgs boson mass (MH) at the International Linear Collider (ILC), using events in which a Higgs boson recoils against a Z boson decaying into a pair of muons or electrons. The analysis is carried out for three center-of-mass energiesps =250, 350, and 500 GeV, and two beam polarizations e L e+ R and e Re+L , for which the polarizationsof e and e+ are Pe-; Pe+ =(-80%, +30%) and (+80%, -30%), respectively. Assuming an integrated luminosity ofmore » 250 fb1 for each beam polarization at ps = 250 GeV, where the best lepton momentum resolution is obtainable, ZH and MH can be determined with a precision of 2.5%and 37 MeV for e L e+R and 2.9% and 41 MeV for e-Re+L , respectively. Regarding a 20 year ILC physics program, the expected precisions for the HZZ coupling and MH are estimated to be 0.4% and 14MeV, respectively. The event selection is designed to optimize the precisions of ZH and MH while minimizing the bias on the measured ZH due to discrepancy in signal efficiencies among Higgs decay modes. For the first time, model independence has been demonstrated to a sub-percent level for the ZH measurement at each of the three center-of-mass energies. The results presented show the impact of center-of-mass energy and beam polarization on the evaluated precisons and serve as« less

A General-purpose Framework for Parallel Processing of Large-scale LiDAR Data

NASA Astrophysics Data System (ADS)

Li, Z.; Hodgson, M.; Li, W.

2016-12-01

Light detection and ranging (LiDAR) technologies have proven efficiency to quickly obtain very detailed Earth surface data for a large spatial extent. Such data is important for scientific discoveries such as Earth and ecological sciences and natural disasters and environmental applications. However, handling LiDAR data poses grand geoprocessing challenges due to data intensity and computational intensity. Previous studies received notable success on parallel processing of LiDAR data to these challenges. However, these studies either relied on high performance computers and specialized hardware (GPUs) or focused mostly on finding customized solutions for some specific algorithms. We developed a general-purpose scalable framework coupled with sophisticated data decomposition and parallelization strategy to efficiently handle big LiDAR data. Specifically, 1) a tile-based spatial index is proposed to manage big LiDAR data in the scalable and fault-tolerable Hadoop distributed file system, 2) two spatial decomposition techniques are developed to enable efficient parallelization of different types of LiDAR processing tasks, and 3) by coupling existing LiDAR processing tools with Hadoop, this framework is able to conduct a variety of LiDAR data processing tasks in parallel in a highly scalable distributed computing environment. The performance and scalability of the framework is evaluated with a series of experiments conducted on a real LiDAR dataset using a proof-of-concept prototype system. The results show that the proposed framework 1) is able to handle massive LiDAR data more efficiently than standalone tools; and 2) provides almost linear scalability in terms of either increased workload (data volume) or increased computing nodes with both spatial decomposition strategies. We believe that the proposed framework provides valuable references on developing a collaborative cyberinfrastructure for processing big earth science data in a highly scalable environment.

Structures of (2E,5E)-2-(4-cyanobenzylidene)-5-(4-dimethylaminobenzylidene)cyclopentanone and (2E,5E)-2-benzylidene-5-cinnamylidenecyclopentanone

NASA Astrophysics Data System (ADS)

Zoto, Christopher A.; MacDonald, John C.

2017-10-01

The X-ray crystal structures of (2E,5E)-2-(4-cyanobenzylidene)-5-(4-dimethylaminobenzylidene)cyclopentanone (I) and (2E,5E)-2-benzylidene-5-cinnamylidenecyclopentanone (II) are presented, compared to the gas phase structures calculated using density functional theory, and discussed in the context of the photophysical behavior exhibited by I and II. Compound I crystallizes in the triclinic space group P 1 bar with a = 6.8743(2) Å, b = 8.8115(2) Å, c = 14.9664(4) Å, α = 77.135(2)°, β = 81.351(2)°, γ = 80.975(2)°, and Z = 2, and exhibits a planar structure. Compound II crystallizes in the monoclinic space group C2/c with a = 33.4281(10) Å, b = 11.9668(4) Å, c = 7.8031(2) Å, β = 92.785(2)°, and Z = 8, and adopts a nonplanar structure in the solid state and calculated structure.

Perceptions about e-cigarette safety may lead to e-smoking during pregnancy.

PubMed

Baeza-Loya, Selina; Viswanath, Humsini; Carter, Asasia; Molfese, David L; Velasquez, Kenia M; Baldwin, Philip R; Thompson-Lake, Daisy G Y; Sharp, Carla; Fowler, J Christopher; De La Garza, Richard; Salas, Ramiro

2014-01-01

Electronic cigarettes (e-cigarettes) are nicotine-delivery devices that are increasingly used, especially by young people. Because e-cigarettes lack many of the substances found in regular tobacco, they are often perceived as a safer smoking alternative, especially in high-risk situations such as pregnancy. However, studies suggest that it is exposure to nicotine that is most detrimental to prenatal development. The authors studied perceptions of tobacco and e-cigarette health risks using a multiple-choice survey. To study the perceived safety of e-cigarettes versus tobacco cigarettes, 184 modified Global Health Youth Surveys (WHO, http://www.who.int/tobacco/surveillance/gyts/en/ ) were completed electronically or on paper. Age range, smoking status, and perceptions about tobacco cigarettes and e-cigarettes were studied. The results verified that younger people use e-cigarettes more than older people. Tobacco cigarettes were perceived as more harmful than e-cigarettes to health in general, including lung cancer and pregnancy. Although more research is necessary, the authors postulate that the perception that e-cigarettes are safer during pregnancy may induce pregnant women to use these devices more freely. Given that nicotine is known to cause fetal harm, pregnant mothers who smoke e-cigarettes could cause even greater harm to the fetus because e-cigarettes are perceived as being safer than tobacco cigarettes. Until more data about the effects of nicotine during pregnancy are available, the authors advocate for labeling of e-cigarettes as potentially harmful, at least during pregnancy.

Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae.

PubMed

Luong, Truc Thanh; Kim, Eun-Hye; Bak, Jong Phil; Nguyen, Cuong Thach; Choi, Sangdun; Briles, David E; Pyo, Suhkneung; Rhee, Dong-Kwon

2015-01-01

Alcohol impairs the host immune system, rendering the host more vulnerable to infection. Therefore, alcoholics are at increased risk of acquiring serious bacterial infections caused by Streptococcus pneumoniae, including pneumonia. Nevertheless, how alcohol affects pneumococcal virulence remains unclear. Here, we showed that the S. pneumoniae type 2 D39 strain is ethanol tolerant and that alcohol upregulates alcohol dehydrogenase E (AdhE) and potentiates pneumolysin (Ply). Hemolytic activity, colonization, and virulence of S. pneumoniae, as well as host cell myeloperoxidase activity, proinflammatory cytokine secretion, and inflammation, were significantly attenuated in adhE mutant bacteria (ΔadhE strain) compared to D39 wild-type bacteria. Therefore, AdhE might act as a pneumococcal virulence factor. Moreover, in the presence of ethanol, S. pneumoniae AdhE produced acetaldehyde and NADH, which subsequently led Rex (redox-sensing transcriptional repressor) to dissociate from the adhE promoter. An increase in AdhE level under the ethanol condition conferred an increase in Ply and H2O2 levels. Consistently, S. pneumoniae D39 caused higher cytotoxicity to RAW 264.7 cells than the ΔadhE strain under the ethanol stress condition, and ethanol-fed mice (alcoholic mice) were more susceptible to infection with the D39 wild-type bacteria than with the ΔadhE strain. Taken together, these data indicate that AdhE increases Ply under the ethanol stress condition, thus potentiating pneumococcal virulence. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Estimating the vegetation canopy height using micro-pulse photon-counting LiDAR data.

PubMed

Nie, Sheng; Wang, Cheng; Xi, Xiaohuan; Luo, Shezhou; Li, Guoyuan; Tian, Jinyan; Wang, Hongtao

2018-05-14

The upcoming space-borne LiDAR satellite Ice, Cloud and land Elevation Satellite-2 (ICESat-2) is scheduled to launch in 2018. Different from the waveform LiDAR system onboard the ICESat, ICESat-2 will use a micro-pulse photon-counting LiDAR system. Thus new data processing algorithms are required to retrieve vegetation canopy height from photon-counting LiDAR data. The objective of this paper is to develop and validate an automated approach for better estimating vegetation canopy height. The new proposed method consists of three key steps: 1) filtering out the noise photons by an effective noise removal algorithm based on localized statistical analysis; 2) separating ground returns from canopy returns using an iterative photon classification algorithm, and then determining ground surface; 3) generating canopy-top surface and calculating vegetation canopy height based on canopy-top and ground surfaces. This automatic vegetation height estimation approach was tested to the simulated ICESat-2 data produced from Sigma Space LiDAR data and Multiple Altimeter Beam Experimental LiDAR (MABEL) data, and the retrieved vegetation canopy heights were validated by canopy height models (CHMs) derived from airborne discrete-return LiDAR data. Results indicated that the estimated vegetation canopy heights have a relatively strong correlation with the reference vegetation heights derived from airborne discrete-return LiDAR data (R 2 and RMSE values ranging from 0.639 to 0.810 and 4.08 m to 4.56 m respectively). This means our new proposed approach is appropriate for retrieving vegetation canopy height from micro-pulse photon-counting LiDAR data.

Forty-five Years of e{sup +}e{sup -} Annihilation Physics: 1956 to 2001

DOE R&D Accomplishments Database

Richter, B.

1984-08-01

The history of e{sup +}e{sup -} physics in the 1950's and 1960's is reviewed, followed by some highlights of the spectacular discoveries in e{sup +}e{sup -} annihilation made during the 1970's. The consolidation of knowledge during the last few years is summarized. Some predictions are made for the field of e{sup +}e{sup -} physics for the next decade and beyond. (LEW)

Development and formative evaluation of the e-Health Implementation Toolkit (e-HIT).

PubMed

Murray, Elizabeth; May, Carl; Mair, Frances

2010-10-18

The use of Information and Communication Technology (ICT) or e-Health is seen as essential for a modern, cost-effective health service. However, there are well documented problems with implementation of e-Health initiatives, despite the existence of a great deal of research into how best to implement e-Health (an example of the gap between research and practice). This paper reports on the development and formative evaluation of an e-Health Implementation Toolkit (e-HIT) which aims to summarise and synthesise new and existing research on implementation of e-Health initiatives, and present it to senior managers in a user-friendly format. The content of the e-HIT was derived by combining data from a systematic review of reviews of barriers and facilitators to implementation of e-Health initiatives with qualitative data derived from interviews of "implementers", that is people who had been charged with implementing an e-Health initiative. These data were summarised, synthesised and combined with the constructs from the Normalisation Process Model. The software for the toolkit was developed by a commercial company (RocketScience). Formative evaluation was undertaken by obtaining user feedback. There are three components to the toolkit--a section on background and instructions for use aimed at novice users; the toolkit itself; and the report generated by completing the toolkit. It is available to download from http://www.ucl.ac.uk/pcph/research/ehealth/documents/e-HIT.xls. The e-HIT shows potential as a tool for enhancing future e-Health implementations. Further work is needed to make it fully web-enabled, and to determine its predictive potential for future implementations.

Development and formative evaluation of the e-Health Implementation Toolkit (e-HIT)

PubMed Central

2010-01-01

Background The use of Information and Communication Technology (ICT) or e-Health is seen as essential for a modern, cost-effective health service. However, there are well documented problems with implementation of e-Health initiatives, despite the existence of a great deal of research into how best to implement e-Health (an example of the gap between research and practice). This paper reports on the development and formative evaluation of an e-Health Implementation Toolkit (e-HIT) which aims to summarise and synthesise new and existing research on implementation of e-Health initiatives, and present it to senior managers in a user-friendly format. Results The content of the e-HIT was derived by combining data from a systematic review of reviews of barriers and facilitators to implementation of e-Health initiatives with qualitative data derived from interviews of "implementers", that is people who had been charged with implementing an e-Health initiative. These data were summarised, synthesised and combined with the constructs from the Normalisation Process Model. The software for the toolkit was developed by a commercial company (RocketScience). Formative evaluation was undertaken by obtaining user feedback. There are three components to the toolkit - a section on background and instructions for use aimed at novice users; the toolkit itself; and the report generated by completing the toolkit. It is available to download from http://www.ucl.ac.uk/pcph/research/ehealth/documents/e-HIT.xls Conclusions The e-HIT shows potential as a tool for enhancing future e-Health implementations. Further work is needed to make it fully web-enabled, and to determine its predictive potential for future implementations. PMID:20955594

Mapping and quantifying geodiversity in land-water transition zones using MBES and topobathymetric LiDAR

NASA Astrophysics Data System (ADS)

Brandbyge Ernstsen, Verner; Skovgaard Andersen, Mikkel; Gergely, Aron; Schulze Tenberge, Yvonne; Al-Hamdani, Zyad; Steinbacher, Frank; Rolighed Larsen, Laurids; Winter, Christian; Bartholomä, Alexander

2016-04-01

Land-water transition zones, like e.g. coastal and fluvial environments, are valuable ecosystems which are often characterised by high biodiversity and geodiversity. However, often these land-water transition zones are difficult or even impossible to map and investigate in high spatial resolution due to the challenging environmental conditions. Combining vessel borne shallow water multibeam echosounder (MBES) surveys ,to cover the subtidal coastal areas and the river channel areas, with airborne topobathymetric light detection and ranging (LiDAR) surveys, to cover the intertidal and supratidal coastal areas and the river floodplain areas, potentially enables full-coverage and high-resolution mapping in these challenging environments. We have carried out MBES and topobathymetric LiDAR surveys in the Knudedyb tidal inlet system, a coastal environment in the Danish Wadden Sea which is part of the Wadden Sea National Park and UNESCO World Heritage, and in the Ribe Vesterå, a fluvial environment in the Ribe Å river catchment discharging into the Knudedyb tidal basin. Detailed digital elevation models (DEMs) with a grid cell size of 0.5 m x 0.5 m were generated from the MBES and the LiDAR point clouds, which both have point densities in the order of 20 points/m2. Morphometric analyses of the DEMs enabled the identification and mapping of the different landforms within the coastal and fluvial environments. Hereby, we demonstrate that vessel borne MBES and airborne topobathymetric LiDAR, here in combination, are promising tools for seamless mapping across land-water transition zones as well as for the quantification of a range of landforms at landscape scale in different land-water transition zone environments. Hence, we demonstrate the potential for mapping and quantifying geomorphological diversity, which is one of the main components of geodiversity and a prerequisite for assessing geoheritage. Acknowledgements This work was funded by the Danish Council for

Structural insights into eRF3 and stop codon recognition by eRF1

PubMed Central

Cheng, Zhihong; Saito, Kazuki; Pisarev, Andrey V.; Wada, Miki; Pisareva, Vera P.; Pestova, Tatyana V.; Gajda, Michal; Round, Adam; Kong, Chunguang; Lim, Mengkiat; Nakamura, Yoshikazu; Svergun, Dmitri I.; Ito, Koichi; Song, Haiwei

2009-01-01

Eukaryotic translation termination is mediated by two interacting release factors, eRF1 and eRF3, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release. The crystal structures of human and Schizosaccharomyces pombe full-length eRF1 in complex with eRF3 lacking the GTPase domain revealed details of the interaction between these two factors and marked conformational changes in eRF1 that occur upon binding to eRF3, leading eRF1 to resemble a tRNA molecule. Small-angle X-ray scattering analysis of the eRF1/eRF3/GTP complex suggested that eRF1's M domain contacts eRF3's GTPase domain. Consistently, mutation of Arg192, which is predicted to come in close contact with the switch regions of eRF3, revealed its important role for eRF1's stimulatory effect on eRF3's GTPase activity. An ATP molecule used as a crystallization additive was bound in eRF1's putative decoding area. Mutational analysis of the ATP-binding site shed light on the mechanism of stop codon recognition by eRF1. PMID:19417105

Investigation of beam self-polarization in the future e + e - circular collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gianfelice-Wendt, E.

The use of resonant depolarization has been suggested for precise beam energy measurements (better than 100 keV) in the e +e - Future Circular Collider (FCC-e +e -) for Z and WW physics at 45 and 80 GeV beam energy respectively. Longitudinal beam polarization would benefit the Z peak physics program; however it is not essential and therefore it will be not investigated here. In this paper the possibility of self-polarized leptons is considered. As a result, preliminary results of simulations in presence of quadrupole misalignments and beam position monitors (BPMs) errors for a simplified FCC-e +e - ring are presented.

Investigation of beam self-polarization in the future e + e - circular collider

DOE PAGES

Gianfelice-Wendt, E.

2016-10-24

The use of resonant depolarization has been suggested for precise beam energy measurements (better than 100 keV) in the e +e - Future Circular Collider (FCC-e +e -) for Z and WW physics at 45 and 80 GeV beam energy respectively. Longitudinal beam polarization would benefit the Z peak physics program; however it is not essential and therefore it will be not investigated here. In this paper the possibility of self-polarized leptons is considered. As a result, preliminary results of simulations in presence of quadrupole misalignments and beam position monitors (BPMs) errors for a simplified FCC-e +e - ring are presented.

E-Learning Agents

ERIC Educational Resources Information Center

Gregg, Dawn G.

2007-01-01

Purpose: The purpose of this paper is to illustrate the advantages of using intelligent agents to facilitate the location and customization of appropriate e-learning resources and to foster collaboration in e-learning environments. Design/methodology/approach: This paper proposes an e-learning environment that can be used to provide customized…

Alternative Fuels Data Center: Status Update: E25 Dispensers Certified, E15

Science.gov Websites

Alternative Fuels Data Center: Status Update: E25 Dispensers Certified, E15 Warranty Upgraded, and Testing on Ethanol Blends Continues (May 2010) on Facebook Tweet about Alternative Fuels Data Center: Status Update Twitter Bookmark Alternative Fuels Data Center: Status Update: E25 Dispensers Certified, E15 Warranty

Experimental status DVCS e p ---> e p gamma and e n ---> e n gamma at Jefferson Lab-Hall A

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Ferdi

2004-06-02

The experiments E00-110 and E03-106 [1] propose to measure the Deep Virtual Compton Scattering process (DVCS) ep --> ep{gamma} and en --> en{gamma} in Hall A at Jefferson Lab with a 5.75 GeV longitudinally polarized electron beam. The exclusivity requires the High Resolution Spectrometer of the Hall A for the detection of the scattered electron ({Delta}p/p = 10^-4), an electromagnetic calorimeter for the detection of the real photon ({sigma}/E<5%) and a scintillator array for the detection of the third particle. A 1 GHz sampling system allows one to deal with pile-up as expected from running detectors at small angles andmore » high luminosity L = 10^37 cm^-2 s^-1. We will describe the apparatus and will explain the method to extract GPDs and evaluate the contributions from higher twists from the measurement of the cross-section difference.« less

E-Combretastatin and E-Resveratrol Structural Modifications: Antimicrobial and Cancer Cell Growth Inhibitory Beta-E-Nitrostyrenes

USDA-ARS?s Scientific Manuscript database

As part of a broad-based SAR investigation of E-resveratrol (strong sirtuin activator and antineoplastic) and the anticancer vascular-targeting combretastatin-type stilbenes, a series of twenty-three beta-E-nitrostyrenes was synthesized in order to evaluate potential antineoplastic, antitubulin poly...

Papillomavirus E6 oncoproteins

PubMed Central

Vande Pol, Scott B.; Klingelhutz, Aloysius J.

2013-01-01

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6 oncoprotein is essential for full transformation. E6 contributes to transformation by associating with cellular proteins, docking on specific acidic LXXLL peptide motifs found on the associated cellular proteins. This review examines insights from recent studies of human and animal E6 proteins that determine the three-dimensional structure of E6 when bound to acidic LXXLL peptides. The structure of E6 is related to recent advances in the purification and identification of E6 associated protein complexes. These E6 protein-complexes, together with other proteins that bind to E6, alter a broad array of biological outcomes including modulation of cell survival, cellular transcription, host cell differentiation, growth factor dependence, DNA damage responses, and cell cycle progression. PMID:23711382

Intermediate boundary conditions for LOD, ADI and approximate factorization methods

NASA Technical Reports Server (NTRS)

Leveque, R. J.

1985-01-01

A general approach to determining the correct intermediate boundary conditions for dimensional splitting methods is presented. The intermediate solution U is viewed as a second order accurate approximation to a modified equation. Deriving the modified equation and using the relationship between this equation and the original equation allows us to determine the correct boundary conditions for U*. This technique is illustrated by applying it to locally one dimensional (LOD) and alternating direction implicit (ADI) methods for the heat equation in two and three space dimensions. The approximate factorization method is considered in slightly more generality.

Recognising Workplace Learning: The Emerging Practices of e-RPL and e-PR

ERIC Educational Resources Information Center

Cameron, Roslyn

2012-01-01

Purpose: The use of e-portfolios in recognition of prior learning (RPL) processes in workplace and professional practice contexts has attracted little attention in the literature due to its emergent nature. This study seeks to explore the growing incidence of e-portfolio-based RPL (e-RPL) and professional recognition (e-PR) processes in Australia…

Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness

PubMed Central

Brimer, Nicole

2017-01-01

Papillomavirus E6 proteins bind to LXXLL peptide motifs displayed on targeted cellular proteins. Alpha genus HPV E6 proteins associate with the cellular ubiquitin ligase E6AP (UBE3A), by binding to an LXXLL peptide (ELTLQELLGEE) displayed by E6AP, thereby stimulating E6AP ubiquitin ligase activity. Beta, Gamma, and Delta genera E6 proteins bind a similar LXXLL peptide (WMSDLDDLLGS) on the cellular transcriptional co-activator MAML1 and thereby repress Notch signaling. We expressed 45 different animal and human E6 proteins from diverse papillomavirus genera to ascertain the overall preference of E6 proteins for E6AP or MAML1. E6 proteins from all HPV genera except Alpha preferentially interacted with MAML1 over E6AP. Among animal papillomaviruses, E6 proteins from certain ungulate (SsPV1 from pigs) and cetacean (porpoises and dolphins) hosts functionally resembled Alpha genus HPV by binding and targeting the degradation of E6AP. Beta genus HPV E6 proteins functionally clustered with Delta, Pi, Tau, Gamma, Chi, Mu, Lambda, Iota, Dyokappa, Rho, and Dyolambda E6 proteins to bind and repress MAML1. None of the tested E6 proteins physically and functionally interacted with both MAML1 and E6AP, indicating an evolutionary split. Further, interaction of an E6 protein was insufficient to activate degradation of E6AP, indicating that E6 proteins that target E6AP co-evolved to separately acquire both binding and triggering of ubiquitin ligase activation. E6 proteins with similar biological function clustered together in phylogenetic trees and shared structural features. This suggests that the divergence of E6 proteins from either MAML1 or E6AP binding preference is a major event in papillomavirus evolution. PMID:29281732

Main factors in E-Learning for the Equivalency Education Program (E-LEEP)

NASA Astrophysics Data System (ADS)

Yel, M. B.; Sfenrianto

2018-03-01

There is a tremendous learning gap between formal education and non-formal education. E-Learning can facilitate non-formal education learners in improving the learning process. In this study, we present the main factors behind the E-learning for the Equivalency Education Program (E-LEEP) initiative in Indonesia. There are four main factors proposed, namely: standardization, learning materials, learning process, and learners’ characteristics. Each factor supports each other to achieve the learning process of E-LEEP in Indonesia. Although not yet proven, the E-learning should be developed followed the main factors for the non-formal education. This is because those factors can improve the quality of E-Learning for the Equivalency Education Program.

Management of an eLearning Evaluation Project: The e3Learning Model

ERIC Educational Resources Information Center

Lam, Paul; McNaught, Carmel

2007-01-01

This article describes the evaluation of purpose-built course websites for university-level teaching and learning developed by a funded project (e3Learning, e3L) in Hong Kong, which was designed to support teachers in three universities to supplement classroom teaching with eLearning. Previous articles on the e3L project have described the…

eHealth literacy in chronic disease patients: An item response theory analysis of the eHealth literacy scale (eHEALS).

PubMed

Paige, Samantha R; Krieger, Janice L; Stellefson, Michael; Alber, Julia M

2017-02-01

Chronic disease patients are affected by low computer and health literacy, which negatively affects their ability to benefit from access to online health information. To estimate reliability and confirm model specifications for eHealth Literacy Scale (eHEALS) scores among chronic disease patients using Classical Test (CTT) and Item Response Theory techniques. A stratified sample of Black/African American (N=341) and Caucasian (N=343) adults with chronic disease completed an online survey including the eHEALS. Item discrimination was explored using bi-variate correlations and Cronbach's alpha for internal consistency. A categorical confirmatory factor analysis tested a one-factor structure of eHEALS scores. Item characteristic curves, in-fit/outfit statistics, omega coefficient, and item reliability and separation estimates were computed. A 1-factor structure of eHEALS was confirmed by statistically significant standardized item loadings, acceptable model fit indices (CFI/TLI>0.90), and 70% variance explained by the model. Item response categories increased with higher theta levels, and there was evidence of acceptable reliability (ω=0.94; item reliability=89; item separation=8.54). eHEALS scores are a valid and reliable measure of self-reported eHealth literacy among Internet-using chronic disease patients. Providers can use eHEALS to help identify patients' eHealth literacy skills. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-Site Sample of Individuals with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Tillmann, J.; Ashwood, K.; Absoud, M.; Bölte, S.; Bonnet-Brilhault, F.; Buitelaar, J. K.; Calderoni, S.; Calvo, R.; Canal-Bedia, R.; Canitano, R.; De Bildt, A.; Gomot, M.; Hoekstra, P. J.; Kaale, A.; McConachie, H.; Murphy, D. G.; Narzisi, A.; Oosterling, I.; Pejovic-Milovancevic, M.; Persico, A. M.; Puig, O.; Roeyers, H.; Rommelse, N.; Sacco, R.; Scandurra, V.; Stanfield, A. C.; Zander, E.; Charman, T.

2018-01-01

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and…

High Density LiDAR and Orthophotography in UXO Wide Area Assessment

DTIC Science & Technology

2008-01-01

4 Figure 2. Helicopter-Mounted LiDAR and Orthophoto Sensor Equipment...4 Figure 3. LiDAR and Orthophoto System Installed on Helicopter........................................ 6 Figure 4. Kirtland Precision...17 Figure 11. Orthophoto Data Density Results

The e-cigarette psychosocial environment, e-cigarette use, and susceptibility to cigarette smoking

PubMed Central

Barrington-Trimis, Jessica L.; Berhane, Kiros; Unger, Jennifer B.; Cruz, Tess Boley; Urman, Robert; Chou, Chih Ping; Howland, Steve; Wang, Kejia; Pentz, Mary Ann; Gilreath, Tamika D.; Huh, Jimi; Leventhal, Adam M.; Samet, Jonathan M.; McConnell, Rob

2016-01-01

Purpose One concern regarding the recent increase in adolescent e-cigarette use is the possibility that e-cigarettes may be used by those who might not otherwise have used cigarettes, and that dual use, or transition to cigarette use alone, may follow. Methods Questionnaire data were obtained in 2014 from 11th/12th grade students attending schools in 12 communities included in the Southern California Children’s Health Study (CHS). We evaluated the cross-sectional association between e-cigarette use, the psychosocial environment (family and friends’ use and approval of e-cigarettes and cigarettes) and susceptibility to future cigarette use among never cigarette smokers (N=1694), using previously validated measures based on reported absence of a definitive commitment not to smoke. Results Among adolescents who had never used cigarettes, 31.8% of past e-cigarette users and 34.6% of current (past 30 day) e-cigarette users indicated susceptibility to cigarette use, compared to 21.0% of never e-cigarette users. The odds of indicating susceptibility to cigarette use were two times higher for current e-cigarette users compared to never users (OR=1.97; 95%CI: 1.21, 3.22). A social environment favorable to e-cigarettes (friends’ use of and positive attitudes toward use of e-cigarettes) was also associated with greater likelihood of susceptibility to cigarette use, independent of an individual’s e-cigarette use. Conclusions E-cigarette use in adolescence, and a pro-e-cigarette social environment, may put adolescents at risk for future use of cigarettes. E-cigarettes may contribute to subsequent cigarette use via nicotine addiction or social normalization of smoking behaviors. PMID:27161417

E-Cigarettes (For Parents)

MedlinePlus

... Safe Videos for Educators Search English Español E-Cigarettes KidsHealth / For Parents / E-Cigarettes What's in this ... en español Los cigarrillos electrónicos What Are E-Cigarettes? E-cigarettes are devices marketed as a safe ...

Measurement of the cross sections of the reactions e +e - → γγ and e +e - → γγγ at LEP

NASA Astrophysics Data System (ADS)

Akwawy, M. Z.; Alexander, G.; Allison, J.; Allport, P. P.; Anderson, K. J.; Armitage, J. C.; Arnison, G. T. J.; Ashton, P.; Azuelos, G.; Baines, J. T. M.; Ball, A. H.; Banks, J.; Barker, G. J.; Barlow, R. J.; Batley, J. R.; Beaudoin, G.; Beck, A.; Becker, J.; Behnke, T.; Bell, K. W.; Bella, G.; Bethke, S.; Biebel, O.; Binder, U.; Bloodworth, I. J.; Bock, P.; Breuker, H.; Brown, R. M.; Brun, R.; Buijs, A.; Burckhart, H. J.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Chrin, J. T. M.; Clarke, P. E. L.; Cohen, I.; Collins, W. J.; Conboy, J. E.; Couch, M.; Coupland, M.; Cuffiani, M.; Dado, S.; Dallavalle, G. M.; De Jong, S.; Debu, P.; Deninno, M. M.; Dieckmann, A.; Dittmar, M.; Dixit, M. S.; Duchovni, E.; Duerdoth, I. P.; Dumas, D. J. P.; Elcombe, P. A.; Estabrooks, P. G.; Etzion, E.; Fabbri, F.; Farthouat, P.; Fischer, H. M.; Fong, D. G.; French, M. T.; Fukunaga, C.; Gaidot, A.; Ganel, O.; Gary, J. W.; Gascon, J.; Geddes, N. I.; Gee, C. N. P.; Geich-Gimbel, C.; Gensler, S. W.; Gentit, F. X.; Giacomelli, G.; Gibson, V.; Gibson, W. R.; Gillies, J. D.; Goldberg, J.; Goodrick, M. J.; Gorn, W.; Granite, D.; Gross, E.; Grunhaus, J.; Hagedorn, H.; Hagemann, J.; Hansroul, M.; Hargrove, C. K.; Harrus, I.; Hart, J.; Hattersley, P. M.; Hauschild, M.; Hawkes, C. M.; Heflin, E.; Hemingway, R. J.; Heuer, R. D.; Hill, J. C.; Hillier, S. J.; Hinshaw, D. A.; Ho, C.; Hobbs, J. D.; Hobson, P. R.; Hochman, D.; Holl, B.; Homer, R. J.; Hou, S. R.; Howarth, C. P.; Hughes-Jones, R. E.; Humbert, R.; Igo-Kemenes, P.; Ihssen, H.; Imrie, D. C.; Janissen, L.; Jawahery, A.; Jeffreys, P. W.; Jeremie, H.; Jimack, M.; Jobes, M.; Jones, R. W. L.; Jovanovic, P.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Kellogg, R. G.; Kennedy, B. W.; Kleinwort, C.; Klem, D. E.; Knop, G.; Kobayashi, T.; Kokott, T. P.; Köpke, L.; Kowalewski, R.; Kreutzmann, H.; Kroll, J.; Kuwano, M.; Kyberd, P.; Lafferty, G. D.; Lamarche, F.; Larson, W. J.; Layter, J. G.; Le Du, P.; Leblanc, P.; Lee, A. M.; Lehto, M. H.; Lellouch, D.; Lennert, P.; Leroy, C.; Lessard, L.; Levegrün, S.; Levinson, L.; Lloyd, S. L.; Loebinger, F. K.; Lorah, J. M.; Lorazo, B.; Losty, M. J.; Ludwig, J.; Ma, J.; Macbeth, A. A.; Mannelli, M.; Marcellini, S.; Maringer, G.; Martin, A. J.; Martin, J. P.; Mashimo, T.; Mättig, P.; Maur, U.; McMahon, T. J.; McNutt, J. R.; Meijers, F.; Menszner, D.; Merritt, F. S.; Mes, H.; Michelini, A.; Middleton, R. P.; Mikenberg, G.; Mildenberger, J.; Miller, D. J.; Milstene, C.; Minowa, M.; Mohr, W.; Moisan, C.; Montanari, A.; Mori, T.; Moss, M. W.; Murphy, P. G.; Murray, W. J.; Nellen, B.; Nguyen, H. H.; Nozaki, M.; O'Dowd, A. J. P.; O'Neale, S. W.; O'Neill, B. P.; Oakham, F. G.; Odorici, F.; Ogg, M.; Oh, H.; Oreglia, M. J.; Orito, S.; Pansart, J. P.; Patrick, G. N.; Pawley, S. J.; Pfister, P.; Pilcher, J. E.; Pinfold, J. L.; Plane, D. E.; Poli, B.; Pouladdej, A.; Prebys, E.; Pritchard, T. W.; Przysiezniak, H.; Quast, G.; Redmond, M. W.; Rees, D. L.; Regimbald, M.; Riles, K.; Roach, C. M.; Robins, S. A.; Rollnik, A.; Roney, J. M.; Rossberg, S.; Rossi, A. M.; Routenburg, P.; Runge, K.; Runolfsson, O.; Sanghera, S.; Sansum, R. A.; Sasaki, M.; Saunders, B. J.; Schaile, A. D.; Schaile, O.; Schappert, W.; Scharff-Hansen, P.; Schreiber, S.; Schwarz, J.; Shapira, A.; Shen, B. C.; Sherwood, P.; Simon, A.; Singh, P.; Siroli, G. P.; Skuja, A.; Smith, A. M.; Smith, T. J.; Snow, G. A.; Springer, R. W.; Sproston, M.; Stephens, K.; Stier, H. E.; Stroehmer, R.; Strom, D.; Takeda, H.; Takeshita, T.; Taras, P.; Thackray, N. J.; Tsukamoto, T.; Turner, M. F.; Tysarczyk-Niemeyer, G.; Van den plas, D.; Van Kooten, R.; VanDalen, G. J.; Vasseur, G.; Virtue, C. J.; von der Schmitt, H.; von Krogh, J.; Wagner, A.; Wahl, C.; Walker, J. P.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Weber, M.; Weisz, S.; Wells, P. S.; Wermes, N.; Weymann, M.; Wilson, G. W.; Wilson, J. A.; Wingerter, I.; Winterer, V.-H.; Wood, N. C.; Wotton, S.; Wyatt, T. R.; Yaari, R.; Yang, Y.; Yekutieli, G.; Yoshida, T.; Zeuner, W.; Zorn, G. T.; OPAL Collaboration

1991-03-01

The cross section of the pure QED process e +e -→ γγ has been measured using data accumulated during the 1989 and 1990 scans of the Z 0 resonance at LEP. Both the energy dependence and the angular distribution are in good agreement with the QED prediction. Upper limits on the branching ratios of Z 0→ γγ, Z 0→ π0γ and Z 0→ ηγ have been set at 1.4×10 -4, 1.4×10 -4 and 2.0×10 -4 respectively. Lower limits on the cutoff parameters of the modified electron propagator have been found to be Λ+ > 117 GeV and Λ- > 110 GeV. The reaction e +e - → γγγ has also been studied and was found to be consistent with the QED prediction. An upper limit on the branching ratio of Z 0→ γγγ has been set at 6.6 × 10 -5. All the limits are given at 95% confidence level.

Ensino de astronomia no 1o. e 2o. ciclos do nível fundamental e na educação de jovens e adultos: exemplos e discussões

NASA Astrophysics Data System (ADS)

Queiroz, A. S. B.; Jafelice, L. C.

2003-08-01

Tem-se constatado uma preocupante carência no ensino de astronomia nos diversos níveis de escolaridade. Neste trabalho discutimos várias práticas didático-pedagógicas que vimos desenvolvendo para crianças, jovens e adultos em processo de alfabetização, visando contribuir para reparar aquela carência. Propomos uma metodologia que incorpora as recentes exigências das políticas públicas educacionais, estimula o desenvolvimento de textos e materiais instrucionais, é compatível com a realidade desse público e é adaptável às respectivas faixas etárias. A observação do céu sempre esteve presente na vida de nossos antepassados, dando suporte à compreensão do ser humano como integrante da natureza. Visamos com este trabalho suprir a deficiência encontrada para se tratar a relação do ser humano com o céu, no ambiente escolar. Os resultados são animadores e envolvem práticas e textos que desenvolvemos e atividades realizadas pelos alunos. No primeiro grupo destacamos o desenvolvimento de várias práticas: "viagem aos planetas" (construímos o "foguete", os planetas em escala, contamos história e redigimos texto de orientação para os professores); "gnômon humano" (os próprios corpos dos alunos são usados para registrar o movimento aparente do Sol); "crateras da Lua" (concretização de "meteoritos" e "solo lunar" de gesso e exploração da relação entre energia cinética do bólido e tamanho da cratera formada); etc. No segundo grupo, produções de desenhos e redações e discussões dos alunos após a realização de cada prática, revelam que estas têm se mostrado muito eficientes, tanto para estimular a imaginação e a fantasia dos envolvidos, como para trabalhar-se habilidades, competências e conteúdos relacionados à astronomia, segundo uma perspectiva interdisciplinar contextualizada. (PPGECNM/UFRN; NUPA/USP; Temáticos/FAPESP)

Search for the rare decays D →h (h('))e+e-

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Albrecht, M.; Alekseev, M.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bai, Y.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Begzsuren, K.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, P. L.; Chen, S. J.; Chen, X. R.; Chen, Y. B.; Cheng, W.; Chu, X. K.; Cibinetto, G.; Cossio, F.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fang, J.; Fang, S. S.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Y. G.; Gao, Z.; Garillon, B.; Garzia, I.; Gilman, A.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guo, A. Q.; Guo, R. P.; Guo, Y. P.; Guskov, A.; Haddadi, Z.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, X. Q.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Irshad, M.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jin, Y.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Keshk, I. K.; Khan, T.; Khoukaz, A.; Kiese, P.; Kiuchi, R.; Kliemt, R.; Koch, L.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuemmel, M.; Kuessner, M.; Kupsc, A.; Kurth, M.; Kühn, W.; Lange, J. S.; Larin, P.; Lavezzi, L.; Leithoff, H.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, J. W.; Li, Jin; Li, K. J.; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, L. Z.; Libby, J.; Lin, C. X.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, D. Y.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. L.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J. B.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, Ke; Liu, L. D.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqing; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lusso, S.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Maldaner, S.; Malik, Q. A.; Mangoni, A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Meng, Z. X.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Mustafa, A.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Pellegrino, J.; Peng, H. P.; Peng, Z. Y.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Pitka, A.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qi, T. Y.; Qian, S.; Qiao, C. F.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Qu, S. Q.; Rashid, K. H.; Redmer, C. F.; Richter, M.; Ripka, M.; Rivetti, A.; Rolo, M.; Rong, G.; Rosner, Ch.; Sarantsev, A.; Savrié, M.; Schoenning, K.; Shan, W.; Shan, X. Y.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Shi, X.; Song, J. J.; Song, W. M.; Song, X. Y.; Sosio, S.; Sowa, C.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, L.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. K.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tan, Y. T.; Tang, C. J.; Tang, G. Y.; Tang, X.; Tapan, I.; Tiemens, M.; Tsednee, B.; Uman, I.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, Dan; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, Meng; Wang, P.; Wang, P. L.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. F.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, Y.; Xiao, D.; Xiao, Y. J.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiong, X. A.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, F.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, R. X.; Yang, Y. H.; Yang, Y. X.; Yang, Yifan; Yang, Z. Q.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, T. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, Q.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhou, Xiaoyu; Zhou, Xu; Zhu, A. N.; Zhu, J.; Zhu, J.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2018-04-01

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h (h('))e+e-), using an e+e- collision sample corresponding to an integrated luminosity of 2.93 fb-1 collected with the BESIII detector at √{s }=3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10-5- 10-6 , providing a large improvement over previous searches.

Search for the rare decays D → h ( h ( ' ) ) e + e -

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2018-04-27

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h(h ('))e +e -), using an e +e - collision sample corresponding to an integrated luminosity of 2.93 fb -1 collected with the BESIII detector at √ s = 3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10 -5 –10 -6, providing a large improvement over previous searches.

Search for the rare decays D → h ( h ( ' ) ) e + e -

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h(h ('))e +e -), using an e +e - collision sample corresponding to an integrated luminosity of 2.93 fb -1 collected with the BESIII detector at √ s = 3.773 GeV . No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10 -5 –10 -6, providing a large improvement over previous searches.

E-cigs . . . Are They Cool? Talking to Teens About E-Cigarettes.

PubMed

Modesto-Lowe, Vania; Alvarado, Camille

2017-09-01

Electronic cigarettes, or e-cigarettes as they are commonly called, have gained wide acceptance among adolescents, especially those with sweet flavors such as bubble gum and cheesecake. Although health effects of e-cigarettes have not been well characterized, their use increases a teen's exposure to nicotine and may serve as a gateway to traditional cigarettes. This article outlines the basics of e-cigarettes and potential health hazards, followed by selected literature on teens' perceptions of e-cigarettes, as well as motivational interviewing strategies that can be used in talking to teens about using electronic cigarettes.

e-Learning Continuance Intention: Moderating Effects of User e-Learning Experience

ERIC Educational Resources Information Center

Lin, Kan-Min

2011-01-01

This study explores the determinants of the e-learning continuance intention of users with different levels of e-learning experience and examines the moderating effects of e-learning experience on the relationships among the determinants. The research hypotheses are empirically validated using the responses received from a survey of 256 users. The…

Adi Quala: application of solar photovoltaic generation in rural medical centres.

PubMed

Allen, P; Welstead, J

1994-01-01

Adi Quala is an Eritrean agricultural town of 14,000 people, and is situated about 70 km south of the capital, Asmara and 30 km from the border with Tigray, Ethiopia. On good days electricity was received from Asmara between 0600 h and 2300 h with nothing available outside these hours. These conditions meant the electricity supply had been a constant problem for the Adi Quala hospital which caters for about 50,000 people with 21 staff. It was for this reason that it was chosen for the first solar system, which provides all essential requirements completely independently from the grid connection. This will in turn enable the hospital to increase the range and reliability of services on offer. Three weeks after the arrival of the equipment the elders were able to have a guided tour of their new local facilities. This included 2kW of photovoltaic panels (installed on the roof), batteries and control equipment powering a range of hospital equipment used in the Mother and Child Health Centre, delivery room, wards, dispensary, clinic and laboratory. Their enormous appreciation was very moving and well articulated in an afternoon of music, speeches and feasting. Eritrea's first solar powered hospital was welcomed into capable hands. The pilot project was successfully installed and commissioned in February 1992, and has performed well to date.

Advances in animal ecology from 3D ecosystem mapping with LiDAR

NASA Astrophysics Data System (ADS)

Davies, A.; Asner, G. P.

2015-12-01

The advent and recent advances of Light Detection and Ranging (LiDAR) have enabled accurate measurement of 3D ecosystem structure. Although the use of LiDAR data is widespread in vegetation science, it has only recently (< 14 years) been applied to animal ecology. Despite such recent application, LiDAR has enabled new insights in the field and revealed the fundamental importance of 3D ecosystem structure for animals. We reviewed the studies to date that have used LiDAR in animal ecology, synthesising the insights gained. Structural heterogeneity is most conducive to increased animal richness and abundance, and increased complexity of vertical vegetation structure is more positively influential than traditionally measured canopy cover, which produces mixed results. However, different taxonomic groups interact with a variety of 3D canopy traits and some groups with 3D topography. LiDAR technology can be applied to animal ecology studies in a wide variety of environments to answer an impressive array of questions. Drawing on case studies from vastly different groups, termites and lions, we further demonstrate the applicability of LiDAR and highlight new understanding, ranging from habitat preference to predator-prey interactions, that would not have been possible from studies restricted to field based methods. We conclude with discussion of how future studies will benefit by using LiDAR to consider 3D habitat effects in a wider variety of ecosystems and with more taxa to develop a better understanding of animal dynamics.

Quantifying biomass consumption and carbon release from the California Rim fire by integrating airborne LiDAR and Landsat OLI data

PubMed Central

Saatchi, Sassan; Casas, Angeles; Koltunov, Alexander; Ustin, Susan; Ramirez, Carlos; Garcia‐Gutierrez, Jorge; Balzter, Heiko

2017-01-01

Abstract Quantifying biomass consumption and carbon release is critical to understanding the role of fires in the carbon cycle and air quality. We present a methodology to estimate the biomass consumed and the carbon released by the California Rim fire by integrating postfire airborne LiDAR and multitemporal Landsat Operational Land Imager (OLI) imagery. First, a support vector regression (SVR) model was trained to estimate the aboveground biomass (AGB) from LiDAR‐derived metrics over the unburned area. The selected model estimated AGB with an R 2 of 0.82 and RMSE of 59.98 Mg/ha. Second, LiDAR‐based biomass estimates were extrapolated to the entire area before and after the fire, using Landsat OLI reflectance bands, Normalized Difference Infrared Index, and the elevation derived from LiDAR data. The extrapolation was performed using SVR models that resulted in R 2 of 0.73 and 0.79 and RMSE of 87.18 (Mg/ha) and 75.43 (Mg/ha) for the postfire and prefire images, respectively. After removing bias from the AGB extrapolations using a linear relationship between estimated and observed values, we estimated the biomass consumption from postfire LiDAR and prefire Landsat maps to be 6.58 ± 0.03 Tg (1012 g), which translate into 12.06 ± 0.06 Tg CO2e released to the atmosphere, equivalent to the annual emissions of 2.57 million cars. PMID:28405539

E-Zines

ERIC Educational Resources Information Center

Todaro, Julie Beth

2004-01-01

In this article, the author talks about e-zines, also identified as ezines. E-zines are online resources most commonly referred to as magazines or "zines" (print-world lingo for do-it-yourself publications) for short. Even though delivered over the Web, they are considered publications with small circulation and are primarily delivered over the…

Threshold and Other Properties of U Particle Production in e{sup +}e{sup -} Annihilation

DOE R&D Accomplishments Database

Perl, M. L.

1976-05-01

The anomalous e..mu.. events produced in e{sup +}e{sup -} annihilation, e{sup +} + e{sup -} ..-->.. e/sup + -/ + ..mu..{sup - +} + missing energy, (1) was explained as the decay products of a pair of U particles produced in the reaction e{sup +} + e{sup -} ..-->.. U{sup +} + U{sup -}. (2) New data is presented on the U particles in the energy region just above their production threshold and results of a study of the nature of the particles carrying off the missing energy in Eq. (1). While presenting these new results the present status of knowledge of the anomalous e..mu.. events and their U particle explanation is briefly reviewed. (JFP)

76 FR 40403 - R.E. Ginna Nuclear Power Plant, LLC, R.E. Ginna Nuclear Power Plant, R.E. Ginna Independent Spent...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-244; Docket No. 72-67] R.E. Ginna Nuclear Power Plant, LLC, R.E. Ginna Nuclear Power Plant, R.E. Ginna Independent Spent Fuel Storage Installation; Notice of... Facility Operating License No. DPR-18, for the R.E. Ginna Nuclear Power Plant (Ginna), currently held by R...

ePortfolios and eGovernment: From Technology to the Entrepreneurial Self

ERIC Educational Resources Information Center

O'Brien, Peter; Osbaldiston, Nick; Kendall, Gavin

2014-01-01

We analyse the electronic portfolio (ePortfolio) in higher education policy and practice.While evangelical accounts of the ePortfolio celebrate its power as a new eLearning technology,we argue that it allows the mutually-reinforcing couple of neoliberalism and the enterprising self to function in ways in which individual difference can be…

All-weld-metal design for AWS E10018M, E11018M and E12018M type electrodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Surian, E.S.; Vedia, L.A. de

This paper presents the results of a research program conducted to design the all-weld metal deposited with AWS A5.5-81 E10018M, E11018M and E12018M SMAW-type electrodes. The role that different alloying elements such as manganese, carbon and chromium play on the tensile properties, hardness and toughness as well as on the microstructure was studied. Criteria for selecting the weld metal composition leading to optimum combination of tensile strength and toughness are suggested. The effect of the variation of heat input, within the requirements of the AWS standard, on the mentioned properties was also analyzed. It was found that the E11018M andmore » E12018M all-weld-metal tensile properties are very sensitive to variations in heat input. For certain values of chemical composition, welding parameter ranges suitable to guarantee the fulfillment of AWS requirements were determined.« less

Categorising E-Learning

ERIC Educational Resources Information Center

Wilson, Amy D.

2012-01-01

Categorising e-learning is almost as problematic as defining the term. In an attempt to quantify/qualify the level of e-learning use in the tertiary sector in New Zealand, the Ministry of Education (MoE) established a classification system for courses in the tertiary sector. The value of this tool was disputed, and a new system was proposed but…

The E-cigarette Social Environment, E-cigarette Use, and Susceptibility to Cigarette Smoking.

PubMed

Barrington-Trimis, Jessica L; Berhane, Kiros; Unger, Jennifer B; Cruz, Tess Boley; Urman, Robert; Chou, Chih Ping; Howland, Steve; Wang, Kejia; Pentz, Mary Ann; Gilreath, Tamika D; Huh, Jimi; Leventhal, Adam M; Samet, Jonathan M; McConnell, Rob

2016-07-01

One concern regarding the recent increase in adolescent e-cigarette use is the possibility that electronic (e-) cigarettes may be used by those who might not otherwise have used cigarettes, and that dual use, or transition to cigarette use alone, may follow. Questionnaire data were obtained in 2014 from 11th/12th grade students attending schools in 12 communities included in the Southern California Children's Health Study. We evaluated the cross-sectional association between e-cigarette use, the social environment (family and friends' use and approval of e-cigarettes and cigarettes), and susceptibility to future cigarette use among never cigarette smokers (N = 1,694), using previously validated measures based on reported absence of a definitive commitment not to smoke. Among adolescents who had never used cigarettes, 31.8% of past e-cigarette users and 34.6% of current (past 30-day) e-cigarette users indicated susceptibility to cigarette use, compared with 21.0% of never e-cigarette users. The odds of indicating susceptibility to cigarette use were two times higher for current e-cigarette users compared with never users (odds ratio = 1.97; 95% confidence interval: 1.21-3.22). A social environment favorable to e-cigarettes (friends' use of and positive attitudes toward the use of e-cigarettes) was also associated with greater likelihood of susceptibility to cigarette use, independent of an individual's e-cigarette use. E-cigarette use in adolescence, and a pro-e-cigarette social environment, may put adolescents at risk for future use of cigarettes. E-cigarettes may contribute to subsequent cigarette use via nicotine addiction or social normalization of smoking behaviors. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Study of K + → π 0 e + ν e γ decay with OKA setup

NASA Astrophysics Data System (ADS)

Polyarush, A. Yu.; OKA Collaboration

2017-12-01

Results of study of the K + → π 0 e + ν e γ decay at OKA setup are presented. 13118 events of this decay have been observed. The branching ratio with cuts {E}γ * > 10 {{MeV}},0.6< {cos}{\\Theta }eγ * < 0.9 , is calculated R=\\frac{Br({K}+\\to {π }0{e}+{v}eγ )}{Br({K}+\\to {π }0{e}+{v}e)}=(0.59+/- 0.02(stat.)+/- 0.03(syst.))× {10}-2. For the asymmetry Aξ we get Aξ = -0.019±0.020(stat.)±0.027(syst.)

Diagnostic Utility of the ADI-R and DSM-5 in the Assessment of Latino Children and Adolescents.

PubMed

Magaña, Sandy; Vanegas, Sandra B

2017-05-01

Latino children in the US are systematically underdiagnosed with Autism Spectrum Disorder (ASD); therefore, it is important that recent changes to the diagnostic process do not exacerbate this pattern of under-identification. Previous research has found that the Autism Diagnostic Interview-Revised (ADI-R) algorithm, based on the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition, Text Revision (DSM-IV-TR), has limitations with Latino children of Spanish speaking parents. We evaluated whether an ADI-R algorithm based on the new DSM-5 classification for ASD would be more sensitive in identifying Latino children of Spanish speaking parents who have a clinical diagnosis of ASD. Findings suggest that the DSM-5 algorithm shows better sensitivity than the DSM-IV-TR algorithm for Latino children.

Prototype development and demonstration for response, emergency staging, communications, uniform management, and evacuation (R.E.S.C.U.M.E.) : R.E.S.C.U.M.E. prototype system architecture.

DOT National Transportation Integrated Search

2014-01-01

This document provides the high-level system architecture for the Prototype Development and Demonstration of a R.E.S.C.U.M.E. system. The requirements addressed in this document are based upon those that can be found in previous R.E.S.C.U.M.E. report...

E-Cigarette Marketing Exposure is Associated with E-cigarette Use among U.S. Youth

PubMed Central

Mantey, Dale S.; Cooper, Maria R.; Clendennen, Stephanie; Pasch, Keryn; Perry, Cheryl L.

2016-01-01

Introduction E-cigarettes are currently the most commonly used tobacco product among U.S. youth. However, unlike conventional cigarettes, e-cigarettes are not subject to marketing restrictions. This study investigates the association between exposure to e-cigarette marketing and susceptibility and use of e-cigarettes in youth. Methods Data were obtained from the 2014 National Youth Tobacco Survey. Participants were 22,007 U.S. middle and high school students. Multivariate logistic regression models assessed the relationship between e-cigarette marketing (internet, print, retail, TV/movies) and current and ever use as well as susceptibility to use e-cigarettes among never e-cigarette users. Results Exposure to each type of e-cigarette marketing was significantly associated with increased likelihood of ever and current use of e-cigarettes among middle and high school students. Exposure was also associated with susceptibility to use of e-cigarettes among current non-users. In multivariate models, as the number of channels of e-cigarette marketing exposure increased, the likelihood of use and susceptibility also increased. Conclusions Findings highlight the significant associations between e-cigarette marketing and e-cigarette use among youth, and the need for longitudinal research on these relationships. PMID:27080732

Modeling marbled murrelet (Brachyramphus marmoratus) habitat using LiDAR-derived canopy data

USGS Publications Warehouse

Hagar, Joan C.; Eskelson, Bianca N.I.; Haggerty, Patricia K.; Nelson, S. Kim; Vesely, David G.

2014-01-01

LiDAR (Light Detection And Ranging) is an emerging remote-sensing tool that can provide fine-scale data describing vertical complexity of vegetation relevant to species that are responsive to forest structure. We used LiDAR data to estimate occupancy probability for the federally threatened marbled murrelet (Brachyramphus marmoratus) in the Oregon Coast Range of the United States. Our goal was to address the need identified in the Recovery Plan for a more accurate estimate of the availability of nesting habitat by developing occupancy maps based on refined measures of nest-strand structure. We used murrelet occupancy data collected by the Bureau of Land Management Coos Bay District, and canopy metrics calculated from discrete return airborne LiDAR data, to fit a logistic regression model predicting the probability of occupancy. Our final model for stand-level occupancy included distance to coast, and 5 LiDAR-derived variables describing canopy structure. With an area under the curve value (AUC) of 0.74, this model had acceptable discrimination and fair agreement (Cohen's κ = 0.24), especially considering that all sites in our sample were regarded by managers as potential habitat. The LiDAR model provided better discrimination between occupied and unoccupied sites than did a model using variables derived from Gradient Nearest Neighbor maps that were previously reported as important predictors of murrelet occupancy (AUC = 0.64, κ = 0.12). We also evaluated LiDAR metrics at 11 known murrelet nest sites. Two LiDAR-derived variables accurately discriminated nest sites from random sites (average AUC = 0.91). LiDAR provided a means of quantifying 3-dimensional canopy structure with variables that are ecologically relevant to murrelet nesting habitat, and have not been as accurately quantified by other mensuration methods.

Cigarette and e-liquid demand and substitution in e-cigarette-naïve smokers.

PubMed

Stein, Jeffrey S; Koffarnus, Mikhail N; Stepanov, Irina; Hatsukami, Dorothy K; Bickel, Warren K

2018-06-01

Behavioral economic methods allow experimental manipulation of price and examination of its effects on tobacco product purchasing. These methods may be used to examine tobacco product abuse liability and to prospectively model possible effects of price regulation. In the present study, we examined multiple measures of behavioral economic demand for cigarettes and e-liquid for use in a second-generation electronic cigarette (e-cigarette) in e-cigarette-naïve cigarette smokers. Twenty-five smokers received an e-cigarette (eGo ONE CT), sampled study e-liquid (24 mg/mL nicotine), and completed recurring sessions in which they used an experimental income to purchase real-world supplies of cigarettes and/or e-liquid. Participants also completed self-report measures of drug effects/liking. When products were available alone, we observed lower demand for e-liquid than for cigarettes. This effect was magnified when cigarettes and e-liquid were available concurrently. In additional assessments, e-liquid served as a partial substitute for cigarettes, but cigarettes did not serve as a substitute for e-liquid. Finally, participants rated e-liquid more poorly than cigarettes on several dimensions of drug effects/liking (any effects, liking, desire, and probability of continued use). We conclude that e-cigarette-naïve smokers value cigarettes more highly than e-liquid across multiple contexts and measurements. Nonetheless, participants still valued e-liquid positively and purchased it frequently, both as a substitute for cigarettes and independently of cigarettes. To understand the variables that influence transitions from exclusive smoking to either dual cigarette/e-cigarette use or exclusive e-cigarette use, future work should systematically examine the role of duration of e-liquid exposure. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Tp-e interval and Tp-e/QT ratio in patients with celiac disease.

PubMed

Demirtaş, K; Yayla, Ç; Yüksel, M; Açar, B; Ünal, S; Ertem, A G; Kaplan, M; Akpinar, M Y; Kiliç, Z M Y; Kayaçetin, E

2017-11-01

Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease. This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects). Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval (64.2±11.0 vs. 44.5±6.0; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.13±0.02; p<0.001) and Tp-e/QTc ratio (0.16±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with celiac disease than control subjects. There was a significant positive correlation between Tp-e/QTc ratio and disease duration in patients with celiac disease (r=0.480, p=0.003) and also there was a significant positive correlation between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p<0.001). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with celiac disease. Whether these changes increase the risk of ventricular arrhythmia deserve further studies. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma.

PubMed

Abou-Alfa, G K; Qin, S; Ryoo, B-Y; Lu, S-N; Yen, C-J; Feng, Y-H; Lim, H Y; Izzo, F; Colombo, M; Sarker, D; Bolondi, L; Vaccaro, G; Harris, W P; Chen, Z; Hubner, R A; Meyer, T; Sun, W; Harding, J J; Hollywood, E M; Ma, J; Wan, P J; Ly, M; Bomalaski, J; Johnston, A; Lin, C-C; Chao, Y; Chen, L-T

2018-06-01

Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG 20 is a cloned arginine degrading enzyme-arginine deiminase-conjugated with polyethylene glycol. The goal of this study was to evaluate this agent as a potential novel therapeutic for HCC after first line systemic therapy. Patients with histologically proven advanced HCC and Child-Pugh up to B7 with prior systemic therapy, were randomized 2 : 1 to ADI-PEG 20 18 mg/m2 versus placebo intramuscular injection weekly. The primary end point was overall survival (OS), with 93% power to detect a 4-5.6 months increase in median OS (one-sided α = 0.025). Secondary end points included progression-free survival, safety, and arginine correlatives. A total of 635 patients were enrolled: median age 61, 82% male, 60% Asian, 52% hepatitis B, 26% hepatitis C, 76% stage IV, 91% Child-Pugh A, 70% progressed on sorafenib and 16% were intolerant. Median OS was 7.8 months for ADI-PEG 20 versus 7.4 for placebo (P = 0.88, HR = 1.02) and median progression-free survival 2.6 months versus 2.6 (P = 0.07, HR = 1.17). Grade 3 fatigue and decreased appetite occurred in <5% of patients. Two patients on ADI-PEG 20 had ≥grade 3 anaphylactic reaction. Death rate within 30 days of end of treatment was 15.2% on ADI-PEG 20 versus 10.4% on placebo, none related to therapy. Post hoc analyses of arginine assessment at 4, 8, 12 and 16 weeks, demonstrated a trend of improved OS for those with more prolonged arginine depletion. ADI-PEG 20 monotherapy did not demonstrate an OS benefit in second line setting for HCC. It was well tolerated. Strategies to enhance prolonged arginine depletion and synergize the effect of ADI-PEG 20 are underway. www.clinicaltrials.gov (NCT 01287585).

A Prospective Trial on Initiation Factor 4E (eIF4E) Overexpression and Cancer Recurrence in Node-Positive Breast Cancer

PubMed Central

McClusky, Derek R.; Chu, Quyen; Yu, Herbert; DeBenedetti, Arrigo; Johnson, Lester W.; Meschonat, Carol; Turnage, Richard; McDonald, John C.; Abreo, Fleurette; Li, Benjamin D. L.

2005-01-01

Objective: A previous study of patients with stage I to III breast cancer showed that those patients whose tumors were in the highest tertile of eIF4E overexpression experienced a higher risk for recurrence. This study was designed to determine whether high eIF4E overexpression predicts cancer recurrence independent of nodal status by specifically targeting patients with node-positive disease. Methods: The prospective trial was designed to accrue 168 patients with node-positive breast cancer to detect a 2.5-fold increase in risk for recurrence. eIF4E level was quantified by Western blots as x-fold elevated compared with breast tissues from noncancer patients. End points measured were disease recurrence and cancer-related death. Statistical analyses performed include survival analysis by the Kaplan-Meier method, log-rank test, and Cox proportional hazard model. Results: One hundred seventy-four patients with node-positive breast cancer were accrued. All patients fulfilled study inclusion and exclusion criteria, treatment protocol, and surveillance requirements, with a compliance rate >95%. The mean eIF4E elevation was 11.0 ± 7.0-fold (range, 1.4–34.3-fold). Based on previously published data, tertile distribution was as follow: 1) lowest tertile (<7.5-fold) = 67 patients, 2) intermediate tertile (7.5–14-fold) = 54 patients, and 3) highest tertile (>14-fold) = 53 patients. At a median follow up of 32 months, patients with the highest tertile had a statistically significant higher cancer recurrence rate (log-rank test, P = 0.002) and cancer-related death rate (P = 0.036) than the lowest group. Relative risk calculations demonstrated that high eIF4E patients had a 2.4-fold increase in relative risk increase for cancer recurrence (95% confidence interval, 1.2–4.1; P = 0.01). Conclusions: In this prospective study designed to specifically address risk for recurrence in patients with node-positive breast cancer, the patients whose tumors were in the highest tertile

Applications of High-Resolution LiDAR Data for the Christina River Basin CZO

NASA Astrophysics Data System (ADS)

Hicks, N. S.; Aufdenkampe, A. K.; Hicks, S. D.

2011-12-01

High-resolution LiDAR data allows for fine scale geomorphic assessment over relatively large spatial extents. Previously available DEMs with a resolution of ten meters or more did not provide adequate resolution for geomorphic characterization of small streams and watersheds or the identification of changes in stream morphology over time. High-resolution LiDAR data for a portion of the Christina River Basin Critical Zone Observatory (CRB-CZO) was obtained during both leaf-off and leaf-on time periods in 2010. Topographic data from these flights is being analyzed with the intent of geomorphic applications such as stream morphology, sediment transport studies, and the evaluation of alluvial deposits. These data and resultant products will also be used in hydrologic and biogeochemical modeling and in biologic and biogeochemical studies of these streams, which are long-term study sites. The LiDAR data also facilitate informed instrument placement and will be used for vegetation studies. The LiDAR data for the CRB-CZO has been used to create a variety of LiDAR based topographic data products including TINs and 0.5-m DEMs. LiDAR derived slope and elevation products were combined with LiDAR intensity images to identify stream channel boundaries and stream centerlines for third through first-order streams. High-resolution slope data also aided in floodplain characterization of these small streams. These high precision stream channel and floodplain characterizations would not have been otherwise possible without extensive field surveying. Future LiDAR flights will allow for the identification of changes in channel morphology over time in low order basins. These characterizations are of particular interest in comparisons between forested and meadow reaches, and in studying the effects of changes in land-use on channel morphology. High-resolution LiDAR data allow for the generation of surface characterizations of importance to a wide range of interdisciplinary researchers.

A multiscale curvature algorithm for classifying discrete return LiDAR in forested environments

Treesearch

Jeffrey S. Evans; Andrew T. Hudak

2007-01-01

One prerequisite to the use of light detection and ranging (LiDAR) across disciplines is differentiating ground from nonground returns. The objective was to automatically and objectively classify points within unclassified LiDAR point clouds, with few model parameters and minimal postprocessing. Presented is an automated method for classifying LiDAR returns as ground...

Scintillation measurements at Bahir Dar during the high solar activity phase of solar cycle 24

NASA Astrophysics Data System (ADS)

Kriegel, Martin; Jakowski, Norbert; Berdermann, Jens; Sato, Hiroatsu; Wassaie Mersha, Mogese

2017-01-01

Small-scale ionospheric disturbances may cause severe radio scintillations of signals transmitted from global navigation satellite systems (GNSSs). Consequently, small-scale plasma irregularities may heavily degrade the performance of current GNSSs such as GPS, GLONASS or Galileo. This paper presents analysis results obtained primarily from two high-rate GNSS receiver stations designed and operated by the German Aerospace Center (DLR) in cooperation with Bahir Dar University (BDU) at 11.6° N, 37.4° E. Both receivers collect raw data sampled at up to 50 Hz, from which characteristic scintillation parameters such as the S4 index are deduced. This paper gives a first overview of the measurement set-up and the observed scintillation events over Bahir Dar in 2015. Both stations are located close to one another and aligned in an east-west, direction which allows us to estimate the zonal drift velocity and spatial dimension of equatorial ionospheric plasma irregularities. Therefore, the lag times of moving electron density irregularities and scintillation patterns are derived by applying cross-correlation analysis to high-rate measurements of the slant total electron content (sTEC) along radio links between a GPS satellite and both receivers and to the associated signal power, respectively. Finally, the drift velocity is derived from the estimated lag time, taking into account the geometric constellation of both receiving antennas and the observed GPS satellites.

Modelling Sensor and Target effects on LiDAR Waveforms

NASA Astrophysics Data System (ADS)

Rosette, J.; North, P. R.; Rubio, J.; Cook, B. D.; Suárez, J.

2010-12-01

The aim of this research is to explore the influence of sensor characteristics and interactions with vegetation and terrain properties on the estimation of vegetation parameters from LiDAR waveforms. This is carried out using waveform simulations produced by the FLIGHT radiative transfer model which is based on Monte Carlo simulation of photon transport (North, 1996; North et al., 2010). The opportunities for vegetation analysis that are offered by LiDAR modelling are also demonstrated by other authors e.g. Sun and Ranson, 2000; Ni-Meister et al., 2001. Simulations from the FLIGHT model were driven using reflectance and transmittance properties collected from the Howland Research Forest, Maine, USA in 2003 together with a tree list for a 200m x 150m area. This was generated using field measurements of location, species and diameter at breast height. Tree height and crown dimensions of individual trees were calculated using relationships established with a competition index determined for this site. Waveforms obtained by the Laser Vegetation Imaging Sensor (LVIS) were used as validation of simulations. This provided a base from which factors such as slope, laser incidence angle and pulse width could be varied. This has enabled the effect of instrument design and laser interactions with different surface characteristics to be tested. As such, waveform simulation is relevant for the development of future satellite LiDAR sensors, such as NASA’s forthcoming DESDynI mission (NASA, 2010), which aim to improve capabilities of vegetation parameter estimation. ACKNOWLEDGMENTS We would like to thank scientists at the Biospheric Sciences Branch of NASA Goddard Space Flight Center, in particular to Jon Ranson and Bryan Blair. This work forms part of research funded by the NASA DESDynI project and the UK Natural Environment Research Council (NE/F021437/1). REFERENCES NASA, 2010, DESDynI: Deformation, Ecosystem Structure and Dynamics of Ice. http

On the impact of a refined stochastic model for airborne LiDAR measurements

NASA Astrophysics Data System (ADS)

Bolkas, Dimitrios; Fotopoulos, Georgia; Glennie, Craig

2016-09-01

Accurate topographic information is critical for a number of applications in science and engineering. In recent years, airborne light detection and ranging (LiDAR) has become a standard tool for acquiring high quality topographic information. The assessment of airborne LiDAR derived DEMs is typically based on (i) independent ground control points and (ii) forward error propagation utilizing the LiDAR geo-referencing equation. The latter approach is dependent on the stochastic model information of the LiDAR observation components. In this paper, the well-known statistical tool of variance component estimation (VCE) is implemented for a dataset in Houston, Texas, in order to refine the initial stochastic information. Simulations demonstrate the impact of stochastic-model refinement for two practical applications, namely coastal inundation mapping and surface displacement estimation. Results highlight scenarios where erroneous stochastic information is detrimental. Furthermore, the refined stochastic information provides insights on the effect of each LiDAR measurement in the airborne LiDAR error budget. The latter is important for targeting future advancements in order to improve point cloud accuracy.

Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder.

PubMed

Tillmann, J; Ashwood, K; Absoud, M; Bölte, S; Bonnet-Brilhault, F; Buitelaar, J K; Calderoni, S; Calvo, R; Canal-Bedia, R; Canitano, R; De Bildt, A; Gomot, M; Hoekstra, P J; Kaale, A; McConachie, H; Murphy, D G; Narzisi, A; Oosterling, I; Pejovic-Milovancevic, M; Persico, A M; Puig, O; Roeyers, H; Rommelse, N; Sacco, R; Scandurra, V; Stanfield, A C; Zander, E; Charman, T

2018-02-21

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

E-Rate to Support Wireless E-Mail, Internet Calling

ERIC Educational Resources Information Center

Trotter, Andrew

2006-01-01

This article deals with federal E-rate program's support of school leaders' Blackberry habit. The Federal Communications Commission (FCC) has cleared the way to allow money from the $2.25 billion program of subsidies for school technology to apply to e-mail service for mobile, wireless devices, such as the BlackBerry, which are increasingly…

Probing the Higgs with angular observables at future e +e – colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Zhen

In this paper, I summarize our recent works on using differential observables to explore the physics potential of future e +e – colliders in the framework of Higgs effective field theory. This proceeding is based upon Refs. 1 and 2. We study angular observables in the e +e – → ZHℓ +ℓ –bmore » $$\\bar{b}$$ channel at future circular e +e – colliders such as CEPC and FCC-ee. Taking into account the impact of realistic cut acceptance and detector effects, we forecast the precision of six angular asymmetries at CEPC (FCC-ee) with center-of-mass energy √s = 240 GeV and 5 (30) ab –1 integrated luminosity. We then determine the projected sensitivity to a range of operators relevant for the Higgsstrahlung process in the dimension-6 Higgs EFT. Our results show that angular observables provide complementary sensitivity to rate measurements when constraining various tensor structures arising from new physics. We further find that angular asymmetries provide a novel means of constraining the “blind spot” in indirect limits on supersymmetric scalar top partners. Finally, we also discuss the possibility of using ZZ-fusion at e +e – machines at different energies to probe new operators.« less

Probing the Higgs with angular observables at future e +e – colliders

DOE PAGES

Liu, Zhen

2016-10-24

In this paper, I summarize our recent works on using differential observables to explore the physics potential of future e +e – colliders in the framework of Higgs effective field theory. This proceeding is based upon Refs. 1 and 2. We study angular observables in the e +e – → ZHℓ +ℓ –bmore » $$\\bar{b}$$ channel at future circular e +e – colliders such as CEPC and FCC-ee. Taking into account the impact of realistic cut acceptance and detector effects, we forecast the precision of six angular asymmetries at CEPC (FCC-ee) with center-of-mass energy √s = 240 GeV and 5 (30) ab –1 integrated luminosity. We then determine the projected sensitivity to a range of operators relevant for the Higgsstrahlung process in the dimension-6 Higgs EFT. Our results show that angular observables provide complementary sensitivity to rate measurements when constraining various tensor structures arising from new physics. We further find that angular asymmetries provide a novel means of constraining the “blind spot” in indirect limits on supersymmetric scalar top partners. Finally, we also discuss the possibility of using ZZ-fusion at e +e – machines at different energies to probe new operators.« less

Utility of LiDAR for large area forest inventory applications

Treesearch

Nicholas S. Skowronski; Andrew J. Lister

2012-01-01

Multi-resource inventory data are used in conjunction with Light Detection and Ranging (LiDAR) data from the Pennsylvania Department of Natural Resource's PAMAP Program to assess the utility of extensive LiDAR acquisitions for large area forest assessments. Background, justification, and initial study designs are presented. The proposed study will involve three...

Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.

PubMed

St Helen, Gideon; Dempsey, Delia A; Havel, Christopher M; Jacob, Peyton; Benowitz, Neal L

2017-09-01

To describe the effect of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes. 11 males and 3 females participated in a 3-day inpatient crossover study with strawberry, tobacco, and their usual flavor e-liquid. Nicotine levels were nominally 18mg/mL in the strawberry (pH 8.29) and tobacco (pH 9.10) e-liquids and ranged between 3-18mg/mL in the usual brands (mean pH 6.80). Each day consisted of a 15-puff session followed by 4h of abstinence, then 90min of ad libitum use. Subjects used a KangerTech mini ProTank 3. After 15 puffs, the amount of nicotine inhaled and systemically retained were not significantly different between the strawberry and tobacco e-liquids but plasma AUC (0 → 180) was significantly higher with the strawberry e-liquid. While not significantly different, C max was 22% higher and various early time point AUCs to measure rate of rise of nicotine in blood ranged between 17 and 23% higher with the strawberry e-liquid compared to the tobacco e-liquid. During ad libitum use, systemic exposure to nicotine (AUC (0 → 90) ) was the same for the tobacco and usual brand e-liquids but were both significantly lower than after using the strawberry e-liquid. The usual flavors were more liked and satisfying than the strawberry and tobacco e-liquids. Flavors influence nicotine exposure through flavor liking, may affect rate of nicotine absorption possibly through pH effects, and contribute to heart rate acceleration and subjective effects of e-cigarettes. E-cigarette users titrate their nicotine exposure but the extent of titration may vary across flavors. Copyright © 2017 Elsevier B.V. All rights reserved.

SEE-GRID eInfrastructure for Regional eScience

NASA Astrophysics Data System (ADS)

Prnjat, Ognjen; Balaz, Antun; Vudragovic, Dusan; Liabotis, Ioannis; Sener, Cevat; Marovic, Branko; Kozlovszky, Miklos; Neagu, Gabriel

In the past 6 years, a number of targeted initiatives, funded by the European Commission via its information society and RTD programmes and Greek infrastructure development actions, have articulated a successful regional development actions in South East Europe that can be used as a role model for other international developments. The SEEREN (South-East European Research and Education Networking initiative) project, through its two phases, established the SEE segment of the pan-European G ´EANT network and successfully connected the research and scientific communities in the region. Currently, the SEE-LIGHT project is working towards establishing a dark-fiber backbone that will interconnect most national Research and Education networks in the region. On the distributed computing and storage provisioning i.e. Grid plane, the SEE-GRID (South-East European GRID e-Infrastructure Development) project, similarly through its two phases, has established a strong human network in the area of scientific computing and has set up a powerful regional Grid infrastructure, and attracted a number of applications from different fields from countries throughout the South-East Europe. The current SEEGRID-SCI project, ending in April 2010, empowers the regional user communities from fields of meteorology, seismology and environmental protection in common use and sharing of the regional e-Infrastructure. Current technical initiatives in formulation are focusing on a set of coordinated actions in the area of HPC and application fields making use of HPC initiatives. Finally, the current SEERA-EI project brings together policy makers - programme managers from 10 countries in the region. The project aims to establish a communication platform between programme managers, pave the way towards common e-Infrastructure strategy and vision, and implement concrete actions for common funding of electronic infrastructures on the regional level. The regional vision on establishing an e

Immunoglobulin E-Mediated Autoimmunity

PubMed Central

Maurer, Marcus; Altrichter, Sabine; Schmetzer, Oliver; Scheffel, Jörg; Church, Martin K.; Metz, Martin

2018-01-01

The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves’ disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, must have been shown to be of benefit to patients as has been done with both of these conditions. This comprehensive review of the literature on IgE-mediated autoallergy focuses on three related questions. What do we know about the prevalence of IgE autoantibodies and their targets in different diseases? What do we know about the relevance of IgE autoantibodies in different diseases? What do we know about the cellular and molecular effects of IgE autoantibodies? In addition to providing answers to these questions, based on a broad review of the literature, we outline the current gaps of knowledge in our understanding of IgE autoantibodies and describe approaches to address them. PMID:29686678

E-cigarette use among students and e-cigarette specialty retailer presence near schools.

PubMed

Bostean, Georgiana; Crespi, Catherine M; Vorapharuek, Patsornkarn; McCarthy, William J

2016-11-01

This study examined the association between presence of e-cigarette specialty retailers near schools and e-cigarette use among middle and high school students in Orange County (OC), CA. The OC subsample of the 2013-2014 California Healthy Kids Survey (N=67,701) was combined with geocoded e-cigarette retailers to determine whether a retailer was present within one-quarter mile of each public school in OC. Multilevel logistic regression models evaluated individual-level and school-level e-cigarette use correlates among middle and high school students. Among middle school students, the presence of an e-cigarette retailer within one-quarter mile of their school predicted lifetime e-cigarette use (OR=1.70, 95% CI=1.02, 2.83), controlling for confounders but no effect for current use. No significant effect was found for high school students. E-cigarette specialty retailers clustered around schools may be an environmental influence on student e-cigarette experimentation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Relativistic corrections to exclusive χc J+γ production from e+e- annihilation

NASA Astrophysics Data System (ADS)

Brambilla, Nora; Chen, Wen; Jia, Yu; Shtabovenko, Vladyslav; Vairo, Antonio

2018-05-01

We calculate in the nonrelativistic QCD (NRQCD) factorization framework all leading relativistic corrections to the exclusive production of χc J+γ in e+e- annihilation. In particular, we compute for the first time contributions induced by octet operators with a chromoelectric field. The matching coefficients multiplying production long distance matrix elements (LDMEs) are determined through perturbative matching between QCD and NRQCD at the amplitude level. Technical challenges encountered in the nonrelativistic expansion of the QCD amplitudes are discussed in detail. The main source of uncertainty comes from the not so well known LDMEs. Accounting for it, we provide the following estimates for the production cross sections at √{s }=10.6 GeV : σ (e+e-→χc 0+γ )=(1.4 ±0.3 ) fb , σ (e+e-→χc 1+γ )=(15.0 ±3.3 ) fb , and σ (e+e-→χc 2+γ )=(4.5 ±1.4 ) fb .

E-cigarette use among students and e-cigarette specialty retailer presence near schools

PubMed Central

Crespi, Catherine M.; Vorapharuek, Patsornkarn; McCarthy, William J.

2016-01-01

Objective This study examined the association between presence of e-cigarette specialty retailers near schools and e-cigarette use among middle and high school students in Orange County (OC), CA. Methods The OC subsample of the 2013–2014 California Healthy Kids Survey (N=67,701) was combined with geocoded e-cigarette retailers to determine whether a retailer was present within one-quarter mile of each public school in OC. Multilevel logistic regression models evaluated individual-level and school-level e-cigarette use correlates among middle and high school students. Results Among middle school students, the presence of an e-cigarette retailer within one-quarter mile of their school predicted lifetime e-cigarette use (OR = 1.70, 95% CI=1.02, 2.83), controlling for confounders but no effect for current use. No significant effect was found for high school students. Conclusions E-cigarette specialty retailers clustered around schools may be an environmental influence on student e-cigarette experimentation. PMID:27770669

Simulating the water budget of a Prairie Potholes complex from LiDAR and hydrological models in North Dakota, USA

USGS Publications Warehouse

Huang, Shengli; Young, Claudia; Abdul-Aziz, Omar I.; Dahal, Devendra; Feng, Min; Liu, Shuguang

2013-01-01

Hydrological processes of the wetland complex in the Prairie Pothole Region (PPR) are difficult to model, partly due to a lack of wetland morphology data. We used Light Detection And Ranging (LiDAR) data sets to derive wetland features; we then modelled rainfall, snowfall, snowmelt, runoff, evaporation, the “fill-and-spill” mechanism, shallow groundwater loss, and the effect of wet and dry conditions. For large wetlands with a volume greater than thousands of cubic metres (e.g. about 3000 m3), the modelled water volume agreed fairly well with observations; however, it did not succeed for small wetlands (e.g. volume less than 450 m3). Despite the failure for small wetlands, the modelled water area of the wetland complex coincided well with interpretation of aerial photographs, showing a linear regression with R2 of around 0.80 and a mean average error of around 0.55 km2. The next step is to improve the water budget modelling for small wetlands.

[Forensic examinations of clothing and other materials found in the coffin by the body of general Władysław Sikorski].

PubMed

Was-Gubała, Jolanta; Brozek-Mucha, Zuzanna

2009-01-01

The report presents the results of identification of garments and other textile products, as well as various materials, e.g. fragments of metals, wood slivers and chemical substances found in the coffin by the body of General Władysław Sikorski. The articles of clothing revealed no damages that could have resulted from a thermal factor, such as fire, high temperature or explosion. Mechanical damages of fabric and knitted fabric resulted from annealing processes and biodegradation of the products. Metallic particles present near the body were fragments of the solder sealing the cover with the coffin. A wood sliver revealed in the left orbital cavity and some of the slivers found on the surface of the shirt originated from Douglas-fir, and other splinters most probably from cypress and elm tree. The presence of struvite, the product of binding of phosphates, ammonia and water resulting from decay of biological materials in the presence of magnesium compounds, was established on the surface of the shirt and the handkerchief.

LiDAR as an Exploration Tool

DOE Data Explorer

Boschmann, D.; Diles, J.; Clarno, J.; Meigs, A.; Walsh, P.

2011-01-01

Using LiDAR to identify structural and volcanic evolution of a Miocene-Pleistocene age bimodal volcanic complex and implications for geothermal potential. The file includes an updated geologic map, methods, and preliminary results.

The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis

PubMed Central

Olmedo-Nieva, Leslie; Muñoz-Bello, J. Omar; Contreras-Paredes, Adriana

2018-01-01

Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter. Through alternative splicing, this pre-mRNA produces a variety of E6 spliced transcripts termed E6*. In pre-malignant lesions and HPV-related cancers, different E6/E6* transcriptional patterns have been found, although they have not been clearly associated to cancer development. Moreover, there is a controversy about the participation of E6* proteins in cancer progression. This review addresses the regulation of E6 splicing and the different functions that have been found for E6* proteins, as well as their possible role in HPV-induced carcinogenesis. PMID:29346309

Study of baryon production mechanism in e+e- annihilation into hadrons

NASA Astrophysics Data System (ADS)

Topaz Collaboration; Aoki, M.; Itoh, R.; Watanabe, Y.; Kaneyuki, K.; Ohshima, Y.; Ochi, A.; Tanimori, T.; Abe, K.; Abe, T.; Adachi, I.; Adachi, K.; Aoki, M.; Emi, K.; Enomoto, R.; Fujii, H.; Fujii, T.; Fujii, K.; Fujimoto, J.; Fujiwara, N.; Hayashii, H.; Hirano, H.; Howell, B.; Ikeda, H.; Inoue, Y.; Itami, S.; Iwasaki, H.; Iwasaki, M.; Kajikawa, R.; Kato, S.; Kawabata, S.; Kichimi, H.; Kobayashi, M.; Koltick, D.; Levine, I.; Mamada, H.; Miyabayashi, K.; Miyamoto, A.; Nagai, K.; Nakabayashi, K.; Nakamura, M.; Nakano, E.; Nitoh, O.; Noguchi, S.; Ochiai, F.; Ohishi, N.; Ohnishi, Y.; Okuno, H.; Okusawa, T.; Shibata, E.; Sugiyama, A.; Suzuki, S.; Takahashi, K.; Takahashi, T.; Teramoto, Y.; Tauchi, T.; Tomoto, M.; Tsukamoto, T.; Tsumura, T.; Uno, S.; Yamamoto, A.; Yamauchi, M.

1998-11-01

The mechanism of baryon-anti-baryon pair production in e+e- annihilation into hadrons has been studied using the TOPAZ detector at the TRISTAN e+e- collider at an average center-of-mass energy of 58 GeV. The distributions of various p¯p correlations were compared with two prominent models: the cluster-fragmentation model and the string-fragmentation model. We rejected the cluster-fragmentation model at the 90% C.L. Furthermore, in the context of the string-fragmentation model, we favor the ``popcorn'' model, rejecting the ``diquark'' model, where a diquark is considered to be a fundamental entity, at the 95% C.L.

Coherent e+e- production at very low transverse momentum at STAR

NASA Astrophysics Data System (ADS)

Yang, Chi

2018-02-01

We report the measurements of e+e- pair production at very low e+e- pair transverse momentum (pT < 0.15 GeV/c) in Au+Au collisions at = 200 GeV and U+U collisions at = 193 GeV using the STAR detector at the Relativistic Heavy Ion Collider. In 60-80% centrality, significant excesses are observed with respect to hadronic cocktails in both Au+Au and U+U collisions. These excess yields can not be explained by a theoretical model calculation incorporating in-medium broadened ρ spectral function. Additionally, the distribution for excess yield is shown and found to be exponential at very low pT.

Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

PubMed Central

Sen, Abhik; Alkon, Daniel L.; Nelson, Thomas J.

2012-01-01

Synaptic loss is the earliest pathological change in Alzheimer disease (AD) and is the pathological change most directly correlated with the degree of dementia. ApoE4 is the major genetic risk factor for the age-dependent form of AD, which accounts for 95% of cases. Here we show that in synaptic networks formed from primary hippocampal neurons in culture, apoE3, but not apoE4, prevents the loss of synaptic networks produced by amyloid β oligomers (amylospheroids). Specific activators of PKCϵ, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid methyl ester and bryostatin 1, protected against synaptic loss by amylospheroids, whereas PKCϵ inhibitors blocked this synaptic protection and also blocked the protection by apoE3. Blocking LRP1, an apoE receptor on the neuronal membrane, also blocked the protection by apoE. ApoE3, but not apoE4, induced the synthesis of PKCϵ mRNA and expression of the PKCϵ protein. Amyloid β specifically blocked the expression of PKCϵ but had no effect on other isoforms. These results suggest that protection against synaptic loss by apoE is mediated by a novel intracellular PKCϵ pathway. This apoE pathway may account for much of the protective effect of apoE and reduced risk for the age-dependent form of AD. This finding supports the potential efficacy of newly developed therapeutics for AD. PMID:22427674

Remote sensing of Sonoran Desert vegetation structure and phenology with ground-based LiDAR

USGS Publications Warehouse

Sankey, Joel B.; Munson, Seth M.; Webb, Robert H.; Wallace, Cynthia S.A.; Duran, Cesar M.

2015-01-01

Long-term vegetation monitoring efforts have become increasingly important for understanding ecosystem response to global change. Many traditional methods for monitoring can be infrequent and limited in scope. Ground-based LiDAR is one remote sensing method that offers a clear advancement to monitor vegetation dynamics at high spatial and temporal resolution. We determined the effectiveness of LiDAR to detect intra-annual variability in vegetation structure at a long-term Sonoran Desert monitoring plot dominated by cacti, deciduous and evergreen shrubs. Monthly repeat LiDAR scans of perennial plant canopies over the course of one year had high precision. LiDAR measurements of canopy height and area were accurate with respect to total station survey measurements of individual plants. We found an increase in the number of LiDAR vegetation returns following the wet North American Monsoon season. This intra-annual variability in vegetation structure detected by LiDAR was attributable to a drought deciduous shrub Ambrosia deltoidea, whereas the evergreen shrub Larrea tridentata and cactus Opuntia engelmannii had low variability. Benefits of using LiDAR over traditional methods to census desert plants are more rapid, consistent, and cost-effective data acquisition in a high-resolution, 3-dimensional context. We conclude that repeat LiDAR measurements can be an effective method for documenting ecosystem response to desert climatology and drought over short time intervals and at detailed-local spatial scale.

Detailed Hydrographic Feature Extraction from High-Resolution LiDAR Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Danny L. Anderson

Detailed hydrographic feature extraction from high-resolution light detection and ranging (LiDAR) data is investigated. Methods for quantitatively evaluating and comparing such extractions are presented, including the use of sinuosity and longitudinal root-mean-square-error (LRMSE). These metrics are then used to quantitatively compare stream networks in two studies. The first study examines the effect of raster cell size on watershed boundaries and stream networks delineated from LiDAR-derived digital elevation models (DEMs). The study confirmed that, with the greatly increased resolution of LiDAR data, smaller cell sizes generally yielded better stream network delineations, based on sinuosity and LRMSE. The second study demonstrates amore » new method of delineating a stream directly from LiDAR point clouds, without the intermediate step of deriving a DEM. Direct use of LiDAR point clouds could improve efficiency and accuracy of hydrographic feature extractions. The direct delineation method developed herein and termed “mDn”, is an extension of the D8 method that has been used for several decades with gridded raster data. The method divides the region around a starting point into sectors, using the LiDAR data points within each sector to determine an average slope, and selecting the sector with the greatest downward slope to determine the direction of flow. An mDn delineation was compared with a traditional grid-based delineation, using TauDEM, and other readily available, common stream data sets. Although, the TauDEM delineation yielded a sinuosity that more closely matches the reference, the mDn delineation yielded a sinuosity that was higher than either the TauDEM method or the existing published stream delineations. Furthermore, stream delineation using the mDn method yielded the smallest LRMSE.« less

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

PubMed Central

Graff, Jeremy R.; Konicek, Bruce W.; Vincent, Thomas M.; Lynch, Rebecca L.; Monteith, David; Weir, Spring N.; Schwier, Phil; Capen, Andrew; Goode, Robin L.; Dowless, Michele S.; Chen, Yuefeng; Zhang, Hong; Sissons, Sean; Cox, Karen; McNulty, Ann M.; Parsons, Stephen H.; Wang, Tao; Sams, Lillian; Geeganage, Sandaruwan; Douglass, Larry E.; Neubauer, Blake Lee; Dean, Nicholas M.; Blanchard, Kerry; Shou, Jianyong; Stancato, Louis F.; Carter, Julia H.; Marcusson, Eric G.

2007-01-01

Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors important in malignancy (e.g., VEGF, cyclin D1) and is thereby an attractive anticancer therapeutic target. Yet to date, no eIF4E-specific therapy has been developed. Herein we report development of eIF4E-specific antisense oligonucleotides (ASOs) designed to have the necessary tissue stability and nuclease resistance required for systemic anticancer therapy. In mammalian cultured cells, these ASOs specifically targeted the eIF4E mRNA for destruction, repressing expression of eIF4E-regulated proteins (e.g., VEGF, cyclin D1, survivin, c-myc, Bcl-2), inducing apoptosis, and preventing endothelial cells from forming vessel-like structures. Most importantly, intravenous ASO administration selectively and significantly reduced eIF4E expression in human tumor xenografts, significantly suppressing tumor growth. Because these ASOs also target murine eIF4E, we assessed the impact of eIF4E reduction in normal tissues. Despite reducing eIF4E levels by 80% in mouse liver, eIF4E-specific ASO administration did not affect body weight, organ weight, or liver transaminase levels, thereby providing the first in vivo evidence that cancers may be more susceptible to eIF4E inhibition than normal tissues. These data have prompted eIF4E-specific ASO clinical trials for the treatment of human cancers. PMID:17786246

Apolipoprotein E genotype in schizophrenia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joober, R.; Lal, S.; Bloom, D.

We investigated the association between schizophrenia and the allelic polymorphism in the apolipoprotein E (Apo E) gene in 51 schizophrenic patients and 35 controls. The Apo E4 allele was equally represented in the schizophrenic group (16%) and the control group (20%) suggesting no association between schizophrenia and the Apo E4 allele. The apolipoprotein E (Apo E) is a polymorphic (E2, E3, and E4) lipoprotein involved in the transmembrane transport of cholesterol and is thought to play an important role in neuronal growth and in the central nervous system response to injury, particularly in the hippocampal region. Recent findings strongly suggestmore » that the Apo E4 allele is associated with cognitive deficits in normal and pathological aging, e.g., Alzheimer`s disease. 5 refs., 1 tab.« less

Measurement of cross sections of the interactions e+e- → ϕϕω and e+e- → ϕϕϕ at center-of-mass energies from 4.008 to 4.600 GeV

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Y. B.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Morello, G.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2017-11-01

Using data samples collected with the BESIII detector at the BEPCII collider at six center-of-mass energies between 4.008 and 4.600 GeV, we observe the processes e+e- → ϕϕω and e+e- → ϕϕϕ. The Born cross sections are measured and the ratio of the cross sections σ (e+e- → ϕϕω) / σ (e+e- → ϕϕϕ) is estimated to be 1.75 ± 0.22 ± 0.19 averaged over six energy points, where the first uncertainty is statistical and the second is systematic. The results represent first measurements of these interactions.

Photocopy of a photograph showing a woman (not E.E. Lape, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of a photograph showing a woman (not E.E. Lape, but possibly E.F. Read) seated outside of southwest corner of Murdock House (circa 1930s?). (Photo found in Lape-Read House, located at U.S. Fish and Wildlife Service - Murdock Hill, Murdock House, South side of Old Clinton Road (U.S. Route 1), 1 mile east of Horse Hill Road, Westbrook, Middlesex County, CT

Anomalous quartic couplings in W+W- gamma production at e+e- colliders

NASA Astrophysics Data System (ADS)

Leil, G. A.; Stirling, W. J.

1995-04-01

We study the process $e^+e^- \\rightarrow W^+W^- \\gamma$ at high-energy $e^+ e^-$ colliders to investigate the effect of genuine quartic $W^+W^-\\gamma\\gamma$ and $W^+W^- Z\\gamma$ anomalous couplings on the cross section. Deviations from the Standard Model predictions are quantified. We show how bounds on the anomalous couplings can be improved by choosing specific initial state helicity combinations. The dependence of the anomalous contributions on the collider energy is studied.

∆ E /∆ E Measurements of Energetic Ions Using CVD Diamond Detectors

DOE PAGES

Alghamdi, Ahmed; Heilbronn, Lawrence; Castellanos, Luis A.; ...

2018-06-20

Experimental and computational results of a Δ E /Δ E diamond detection system are presented. The Δ E /Δ E detection system was evaluated using energetic proton and iron beams striking thick polyethylene targets at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). The measured data for diamond sensor A show good agreement with the Geant4 simulation. In addition, simulations have demonstrated the ability to identify hydrogen isotopes using a diamond detection system.

∆ E /∆ E Measurements of Energetic Ions Using CVD Diamond Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alghamdi, Ahmed; Heilbronn, Lawrence; Castellanos, Luis A.

Experimental and computational results of a Δ E /Δ E diamond detection system are presented. The Δ E /Δ E detection system was evaluated using energetic proton and iron beams striking thick polyethylene targets at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL). The measured data for diamond sensor A show good agreement with the Geant4 simulation. In addition, simulations have demonstrated the ability to identify hydrogen isotopes using a diamond detection system.

Search for the rare decay D+→D0e+νe

NASA Astrophysics Data System (ADS)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, Y.; Farinelli, R.; Fava, L.; Fegan, S.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, Kang; Li, Ke; Li, Lei; Li, P. L.; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Y. B.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. M.; Liu, Huanhuan; Liu, Huihui; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Morello, G.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Papenbrock, M.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wang, Zongyuan; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yang; Zhang, Yao; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

2017-11-01

Using a data set with an integrated luminosity of 2.93 fb-1 collected at √{s }=3.773 GeV with the BESIII detector operating at the BEPCII storage rings, we search for the rare decay D+→D0e+νe. No signal events are observed. We set the upper limit on the branching fraction for D+→D0e+νe to be 1.0 ×1 0-4 at the 90% confidence level.

Distinct signals of the gauge-Higgs unification in e+e- collider experiments

NASA Astrophysics Data System (ADS)

Funatsu, Shuichiro; Hatanaka, Hisaki; Hosotani, Yutaka; Orikasa, Yuta

2017-12-01

Effects of Kaluza-Klein excited neutral vector bosons (Z‧ bosons) in the gauge-Higgs unification on e+e- → q bar q ,ℓ+ℓ- cross sections are studied, particularly in future e+e- collider experiments with polarized beams. Significant deviations in the energy and polarization dependence in σ (μ+μ-), the lepton forward-backward asymmetry, Rb (μ) ≡ σ (b bar b) / σ (μ+μ-) and the left-right asymmetry from the standard model are predicted.

Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts.

PubMed

Bazrgar, Masood; Karimi, Mehran; Fathzadeh, Mohsen; Senemar, Sara; Peiravian, Farah; Shojaee, Ashraf; Saadat, Mostafa

2008-12-01

Apolipoprotein E (apoE) with three major alleles E2, E3 and E4 is one of the critical genes in lipid metabolism. Common apoE alleles are in association with an increase in risk for central nervous and cardiovascular diseases such as Alzheimer's disease, dementia, multiple sclerosis, atherosclerosis, coronary heart disease, hyperlipoproteinemia and stroke. ApoE3 is known as the most frequent allele in all populations, while association of apoE gene polymorphism with reported diseases have mostly been related to other two major alleles especially apoE4. To determine of apoE alleles frequencies in Southern Iran and comparison of those frequencies with other populations. DNA was extracted from the whole blood of 198 healthy unrelated candidates from population of Fars Province, Southern Iran, for apoE genotyping who were checked up by a physician. The frequencies of apoE alleles were compared with other populations by chi(2) test. The frequencies of E2, E3 and E4 were 0.063, 0.886 and 0.051 respectively. These values were similar to those reported from populations of Kuwait, Oman, Lebanon, India, Turkey, Greece, Spain, Sardinia Islands of Italy and two Iranian populations but were different from South of Italy and Caucasians in other Europe regions, American, American-Indian, African, East Asian and Saudi populations (P < 0.05). The frequency of E4 allele as a genetic risk factor for some multifactorial diseases in the population of Southern Iran is in the lowest reported amounts in the world. Iranian population has Caucasoid origin but differs from some Caucasian populations in Europe and America. The results of present study are in agreement with the historical evidences which show admixture of Iranian population with other populations and some studies based on genetic polymorphisms in the population of Southern Iran.

Second-order Born calculation of coplanar symmetric (e, 2e) process on Mg

NASA Astrophysics Data System (ADS)

Zhang, Yong-Zhi; Wang, Yang; Zhou, Ya-Jun

2014-06-01

The second-order distorted wave Born approximation (DWBA) method is employed to investigate the triple differential cross sections (TDCS) of coplanar doubly symmetric (e, 2e) collisions for magnesium at excess energies of 6 eV-20 eV. Comparing with the standard first-order DWBA calculations, the inclusion of the second-order Born term in the scattering amplitude improves the degree of agreement with experiments, especially for backward scattering region of TDCS. This indicates that the present second-order Born term is capable to give a reasonable correction to DWBA model in studying coplanar symmetric (e, 2e) problems of two-valence-electron target in low energy range.

U boson search in the e+ + e- → μ+μ-γ process

NASA Astrophysics Data System (ADS)

Curciarello, Francesca; KLOE/KLOE2 Collaboration

2013-03-01

Following recent puzzling astrophysical results and recent theoretical studies, a search for a relatively low mass (1 GeV) new vector gauge boson (called the U boson) was performed by means of the KLOE detector. Investigations were carried out using the Initial State Radiation and searching for the signal from the U boson in the e+ + e- → μ+μ-γ process. The KLOE experiment, at the phi-factory DAΦNE (INFN-LNF), is the first to have exploited ISR to precisely determine cross sections of e+ + e- → π+π-γ(γ) and e+ + e- → μ+μ-γ(γ) processes below 1 GeV. Investigations were based on the data sample collected in 2002, which corresponds to integrated luminosity of 239.29 pb-1. No evidence was found and a preliminary upper limit in the mass range between 600 and 1000 MeV was extracted.

Impact of survey workflow on precision and accuracy of terrestrial LiDAR datasets

NASA Astrophysics Data System (ADS)

Gold, P. O.; Cowgill, E.; Kreylos, O.

2009-12-01

Ground-based LiDAR (Light Detection and Ranging) survey techniques are enabling remote visualization and quantitative analysis of geologic features at unprecedented levels of detail. For example, digital terrain models computed from LiDAR data have been used to measure displaced landforms along active faults and to quantify fault-surface roughness. But how accurately do terrestrial LiDAR data represent the true ground surface, and in particular, how internally consistent and precise are the mosaiced LiDAR datasets from which surface models are constructed? Addressing this question is essential for designing survey workflows that capture the necessary level of accuracy for a given project while minimizing survey time and equipment, which is essential for effective surveying of remote sites. To address this problem, we seek to define a metric that quantifies how scan registration error changes as a function of survey workflow. Specifically, we are using a Trimble GX3D laser scanner to conduct a series of experimental surveys to quantify how common variables in field workflows impact the precision of scan registration. Primary variables we are testing include 1) use of an independently measured network of control points to locate scanner and target positions, 2) the number of known-point locations used to place the scanner and point clouds in 3-D space, 3) the type of target used to measure distances between the scanner and the known points, and 4) setting up the scanner over a known point as opposed to resectioning of known points. Precision of the registered point cloud is quantified using Trimble Realworks software by automatic calculation of registration errors (errors between locations of the same known points in different scans). Accuracy of the registered cloud (i.e., its ground-truth) will be measured in subsequent experiments. To obtain an independent measure of scan-registration errors and to better visualize the effects of these errors on a registered point

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qiu, Jiazhang; Sheedlo, Michael J.; Yu, Kaiwen

Signaling by ubiquitination regulates virtually every cellular process in eukaryotes. Covalent attachment of ubiquitin to a substrate is catalyzed by the E1, E2 and E3 three-enzyme cascade 1, which links the C terminus of ubiquitin via an isopeptide bond mostly to the ε-amino group of a lysine of the substrate. Given the essential roles of ubiquitination in the regulation of the immune system, it is not surprising that the ubiquitination network is a common target for diverse infectious agents 2. For example, many bacterial pathogens exploit ubiquitin signaling using virulence factors that function as E3 ligases, deubiquitinases 3 or asmore » enzymes that directly attack ubiquitin 4. The bacterial pathogen Legionella pneumophila utilizes approximately 300 effectors that modulate diverse host processes to create a niche permissive for its replication in phagocytes 5. Here we demonstrate that members of the SidE effector family (SidEs) of L. pneumophila ubiquitinate multiple Rab small GTPases associated with the endoplasmic reticulum (ER). Moreover, we show that these proteins are capable of catalyzing ubiquitination without the need for the E1 and E2 enzymes. The E1/E2-independent ubiquitination catalyzed by these enzymes requires NAD but not ATP and Mg2+. A putative mono ADP-ribosyltransferase (mART) motif critical for the ubiquitination activity is also essential for the role of SidEs in intracellular bacterial replication in a protozoan host. These results establish that ubiquitination can be catalyzed by a single enzyme.« less

Evidence for the Decay D0→K-π+π-e+νe

NASA Astrophysics Data System (ADS)

Artuso, M.; Blusk, S.; Butt, J.; Li, J.; Menaa, N.; Mountain, R.; Nisar, S.; Randrianarivony, K.; Sia, R.; Skwarnicki, T.; Stone, S.; Wang, J. C.; Zhang, K.; Bonvicini, G.; Cinabro, D.; Dubrovin, M.; Lincoln, A.; Asner, D. M.; Edwards, K. W.; Naik, P.; Briere, R. A.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Adam, N. E.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.; Jones, C. D.; Kandaswamy, J.; Kreinick, D. L.; Kuznetsov, V. E.; Mahlke-Krüger, H.; Mohapatra, D.; Onyisi, P. U. E.; Patterson, J. R.; Peterson, D.; Pivarski, J.; Riley, D.; Ryd, A.; Sadoff, A. J.; Schwarthoff, H.; Shi, X.; Stroiney, S.; Sun, W. M.; Wilksen, T.; Athar, S. B.; Patel, R.; Potlia, V.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Selen, M.; White, E. J.; Wiss, J.; Mitchell, R. E.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.; Gao, K. Y.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.; Poling, R.; Scott, A. W.; Smith, A.; Zweber, P.; Dobbs, S.; Metreveli, Z.; Seth, K. K.; Tomaradze, A.; Ernst, J.; Ecklund, K. M.; Severini, H.; Love, W.; Savinov, V.; Aquines, O.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J.; Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B.; Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Hu, D.; Moziak, B.; Napolitano, J.; He, Q.; Insler, J.; Muramatsu, H.; Park, C. S.; Thorndike, E. H.; Yang, F.

2007-11-01

Using a 281pb-1 data sample collected at the ψ(3770) with the CLEO-c detector, we present the first absolute branching fraction measurement of the decay D0→K-π+π-e+νe at a statistical significance of about 4.0 standard deviations. We find 10 candidates consistent with the decay D0→K-π+π-e+νe. The probability that a background fluctuation accounts for this signal is less than 4.1×10-5. We find B(D0→K-π+π-e+νe)=[2.8-1.1+1.4(stat)±0.3(syst)]×10-4. By restricting the invariant mass of the hadronic system to be consistent with K1(1270), we obtain the product of branching fractions B(D0→K1-(1270)e+νe)×B(K1-(1270)→K-π+π-)=[2.5-1.0+1.3(stat)±0.2(syst)]×10-4. Using B(K1-(1270)→K-π+π-)=(33±3)%, we obtain B(D0→K1-(1270)e+νe)=[7.6-3.0+4.1(stat)±0.6(syst)±0.7]×10-4. The last error accounts for the uncertainties in the measured K1-(1270)→K-π+π- branching fractions.

Geotechnical applications of LiDAR pertaining to geomechanical evaluation and hazard identification

NASA Astrophysics Data System (ADS)

Lato, Matthew J.

Natural hazards related to ground movement that directly affect the safety of motorists and highway infrastructure include, but are not limited to, rockfalls, rockslides, debris flows, and landslides. This thesis specifically deals with the evaluation of rockfall hazards through the evaluation of LiDAR data. Light Detection And Ranging (LiDAR) is an imaging technology that can be used to delineate and evaluate geomechanically-controlled hazards. LiDAR has been adopted to conduct hazard evaluations pertaining to rockfall, rock-avalanches, debris flows, and landslides. Characteristics of LiDAR surveying, such as rapid data acquisition rates, mobile data collection, and high data densities, pose problems to traditional CAD or GIS-based mapping methods. New analyses methods, including tools specifically oriented to geomechanical analyses, are needed. The research completed in this thesis supports development of new methods, including improved survey techniques, innovative software workflows, and processing algorithms to aid in the detection and evaluation of geomechanically controlled rockfall hazards. The scientific research conducted between the years of 2006-2010, as presented in this thesis, are divided into five chapters, each of which has been published by or is under review by an international journal. The five research foci are: (i) geomechanical feature extraction and analysis using LiDAR data in active mining environments; (ii) engineered monitoring of rockfall hazards along transportation corridors: using mobile terrestrial LiDAR; (iii) optimization of LiDAR scanning and processing for automated structural evaluation of discontinuities in rockmasses; (iv) location orientation bias when using static LiDAR data for geomechanical analysis; and (v) evaluating roadside rockmasses for rockfall hazards from LiDAR data: optimizing data collection and processing protocols. The research conducted pertaining to this thesis has direct and significant implications with

E-Procurement Success

DTIC Science & Technology

2003-03-01

markets demands that it be given far greater attention than it has received in the past. The new competitive landscape of the twenty-first century...1990’s, the ability for companies to network their electronic systems became cheaper and more reliable which truly brought for the age of e -Business...several business processes into the electronic environment of cyberspace, commonly referred to as e -Business. While e -Business includes all aspects of

Study of the process e+e-→π+π-η using initial state radiation

NASA Astrophysics Data System (ADS)

Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Brown, D. N.; Kolomensky, Yu. G.; Fritsch, M.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kozyrev, E. A.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Gary, J. W.; Long, O.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Kim, J.; Li, Y.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Smith, J. G.; Wagner, S. R.; Bernard, D.; Verderi, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rotondo, M.; Zallo, A.; Passaggio, S.; Patrignani, C.; Lacker, H. M.; Bhuyan, B.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Le Diberder, F.; Lutz, A. M.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Banerjee, Sw.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Robertson, S. H.; Seddon, R. M.; Dey, B.; Neri, N.; Palombo, F.; Cheaib, R.; Cremaldi, L.; Godang, R.; Summers, D. J.; Taras, P.; De Nardo, G.; Sciacca, C.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Gaz, A.; Margoni, M.; Posocco, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Calderini, G.; Chauveau, J.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Rossi, A.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Rama, M.; Rizzo, G.; Walsh, J. J.; Zani, L.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Heß, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Luitz, S.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Ratcliff, B. N.; Roodman, A.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Purohit, M. V.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Ahmed, H.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Albert, J.; Beaulieu, A.; Bernlochner, F. U.; King, G. J.; Kowalewski, R.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Prepost, R.; Wu, S. L.; BaBar Collaboration

2018-03-01

We study the process e+e- →π+π- η γ , where the photon is radiated from the initial state. About 8000 fully reconstructed events of this process are selected from the BABAR data sample with an integrated luminosity of 469 fb-1 . Using the π+π-η invariant mass spectrum, we measure the e+e-→π+π- η cross section in the e+e- center-of-mass energy range from 1.15 to 3.5 GeV. The cross section is well described by the Vector-Meson dominance model with four ρ -like states. We observe 49 ±9 events of the J /ψ decay to π+π- η and measure the product ΓJ /Ψ →e+e-BJ /Ψ →π+π-η=2.34 ±0.4 3stat±0.1 6syst eV .

Multi-temporal LiDAR and Landsat quantification of fire-induced changes to forest structure

USGS Publications Warehouse

McCarley, T. Ryan; Kolden, Crystal A.; Vaillant, Nicole M.; Hudak, Andrew T.; Smith, Alistair M.S.; Wing, Brian M.; Kellogg, Bryce; Kreitler, Jason R.

2017-01-01

Measuring post-fire effects at landscape scales is critical to an ecological understanding of wildfire effects. Predominantly this is accomplished with either multi-spectral remote sensing data or through ground-based field sampling plots. While these methods are important, field data is usually limited to opportunistic post-fire observations, and spectral data often lacks validation with specific variables of change. Additional uncertainty remains regarding how best to account for environmental variables influencing fire effects (e.g., weather) for which observational data cannot easily be acquired, and whether pre-fire agents of change such as bark beetle and timber harvest impact model accuracy. This study quantifies wildfire effects by correlating changes in forest structure derived from multi-temporal Light Detection and Ranging (LiDAR) acquisitions to multi-temporal spectral changes captured by the Landsat Thematic Mapper and Operational Land Imager for the 2012 Pole Creek Fire in central Oregon. Spatial regression modeling was assessed as a methodology to account for spatial autocorrelation, and model consistency was quantified across areas impacted by pre-fire mountain pine beetle and timber harvest. The strongest relationship (pseudo-r2 = 0.86, p < 0.0001) was observed between the ratio of shortwave infrared and near infrared reflectance (d74) and LiDAR-derived estimate of canopy cover change. Relationships between percentage of LiDAR returns in forest strata and spectral indices generally increased in strength with strata height. Structural measurements made closer to the ground were not well correlated. The spatial regression approach improved all relationships, demonstrating its utility, but model performance declined across pre-fire agents of change, suggesting that such studies should stratify by pre-fire forest condition. This study establishes that spectral indices such as d74 and dNBR are most sensitive to wildfire-caused structural changes

Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins.

PubMed

Bohl, J; Hull, B; Vande Pol, S B

2001-01-01

Productively infected bovine fibropapillomas were examined for bovine papillomavirus type 1 (BPV-1) E7 localization. BPV-1 E7 was observed in the cytoplasm of basal and lower spinous epithelial cells, coexpressed in the cytoplasm of basal cells with the E5 oncoprotein. E7 was also observed in nucleoli throughout the basal and spinous layers but not in the granular cell layer. Ectopic expression of E7 in cultured epithelial cells gave rise to localization similar to that seen in productive fibropapillomas, with cytoplasmic and nucleolar expression observed. Consistent with the coexpression of E7 and E5 in basal keratinocytes, BPV-1 E7 cooperated with E5 as well as E6 in an anchorage independence transformation assay. While E5 is expressed in both basal and superficial differentiating keratinocytes, BPV-1 E7 is only observed in basal and lower spinous epithelial cells. Therefore, BPV-1 E7 may serve to modulate the cellular response of basal epithelial cells to E5 expression.

Recurrent Themes in E-Learning: A Narrative Analysis of Major E-Learning Reports

ERIC Educational Resources Information Center

Waight, Consuelo L.; Willging, Pedro; Wentling, Tim

2004-01-01

E-learning, sometimes referred to as online learning, Web-based learning, distance learning, and technology-based learning, among other names, is a concept that has garnered significant global attention. This broad attention to e-learning has resulted in numerous e-learning reports. In doing extensive Web searches for e-learning reports, the…

Investigating the performance of LiDAR-derived biomass information in hydromechanic slope stability modelling

NASA Astrophysics Data System (ADS)

Schmaltz, Elmar; Steger, Stefan; Bogaard, Thom; Van Beek, Rens; Glade, Thomas

2017-04-01

Hydromechanic slope stability models are often used to assess the landslide susceptibility of hillslopes. Some of these models are able to account for vegetation related effects when assessing slope stability. However, spatial information of required vegetation parameters (especially of woodland) that are defined by land cover type, tree species and stand density are mostly underrepresented compared to hydropedological and geomechanical parameters. The aim of this study is to assess how LiDAR-derived biomass information can help to distinguish distinct tree stand-immanent properties (e.g. stand density and diversity) and further improve the performance of hydromechanic slope stability models. We used spatial vegetation data produced from sophisticated algorithms that are able to separate single trees within a stand based on LiDAR point clouds and thus allow an extraordinary detailed determination of the aboveground biomass. Further, this information is used to estimate the species- and stand-related distribution of the subsurface biomass using an innovative approach to approximate root system architecture and development. The hydrological tree-soil interactions and their impact on the geotechnical stability of the soil mantle are then reproduced in the dynamic and spatially distributed slope stability model STARWARS/PROBSTAB. This study highlights first advances in the approximation of biomechanical reinforcement potential of tree root systems in tree stands. Based on our findings, we address the advantages and limitations of highly detailed biomass information in hydromechanic modelling and physically based slope failure prediction.

A Descriptive Review of Mainline E-Learning Projects in the European Union: E-Learning Action Plan and E-Learning Program

ERIC Educational Resources Information Center

Uzunboylu, Huseyin

2006-01-01

This study's purpose was to survey the literature on European Union (EU) e-learning strategies specifically related to two mainline e-learning projects: the learning Action Plan and the E-Learning Program. Results of the evaluation and interpretation of the literature show that the European Commission has positively impacted European Union…

Depth Acuity Methodology for Electronic 3D Displays: eJames (eJ)

DTIC Science & Technology

2016-07-01

AFRL-RH-WP-TR-2016-0060 Depth Acuity Methodology for Electronic 3D Displays: eJames (eJ) Eric L. Heft, John McIntire...AND SUBTITLE Depth Acuity Methodology for Electronic 3D Displays: eJames (eJ) 5a. CONTRACT NUMBER FA8650-08-D-6801-0050 5b. GRANT NUMBER...of 3D electronic displays: one active-eyewear Stereo 3D (S3D) and two non-eyewear full parallax Field-of-Light Display (FoLD) systems. The two FoLD

Measurement of cross sections of the interactions e + e - → φφω and e + e - → φφφ at center-of-mass energies from 4.008 to 4.600 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

Using dmore » ata samples collected with the BESIII detector at the BEPCII collider at six center-of-mass energies between 4.008 and 4.600 GeV, we observe the processes e + e - → φ φ ω and e + e - → φ φ φ . The Born cross sections are measured and the ratio of the cross sections σ ( e + e - → φ φ ω ) / σ ( e + e - → φ φ φ ) is estimated to be 1.75 ± 0.22 ± 0.19 averaged over six energy points, where the first uncertainty is statistical and the second is systematic. The results represent first measurements of these interactions.« less

Measurement of cross sections of the interactions e + e - → φφω and e + e - → φφφ at center-of-mass energies from 4.008 to 4.600 GeV

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2017-09-14

Using dmore » ata samples collected with the BESIII detector at the BEPCII collider at six center-of-mass energies between 4.008 and 4.600 GeV, we observe the processes e + e - → φ φ ω and e + e - → φ φ φ . The Born cross sections are measured and the ratio of the cross sections σ ( e + e - → φ φ ω ) / σ ( e + e - → φ φ φ ) is estimated to be 1.75 ± 0.22 ± 0.19 averaged over six energy points, where the first uncertainty is statistical and the second is systematic. The results represent first measurements of these interactions.« less

Applicability of Aerial Green LiDAR to a Large River in the Western United States

NASA Astrophysics Data System (ADS)

Conner, J. T.; Welcker, C. W.; Cooper, C.; Faux, R.; Butler, M.; Nayegandhi, A.

2013-12-01

In October 2012, aerial green LiDAR data were collected in the Snake River (within Idaho and Oregon) to test this emerging technology in a large river with poor water clarity. Six study areas (total of 30 river miles spread out over 250 river miles) were chosen to represent a variety of depths, channel types, and surface conditions to test the accuracy, depth penetration, data density of aerial green LiDAR. These characteristics along with cost and speed of acquisition were compared to other bathymetric survey techniques including rod surveys (total station and RTK-GPS), single-beam sonar, and multibeam echosounder (MBES). The green LiDAR system typically measured returns from the riverbed through 1-2 meters of water, which was less than one Secchi depth. However, in areas with steep banks or aquatic macrophytes, LiDAR returns from the riverbed were less frequent or non-existent. In areas of good return density, depths measured from green LiDAR data corresponded well with previously collected data sets from traditional bathymetric survey techniques. In such areas, the green LiDAR point density was much higher than both rod and single beam sonar surveys, yet lower than MBES. The green LiDAR survey was also collected more efficiently than all other methods. In the Snake River, green LiDAR does not provide a method to map the entire riverbed as it only receives bottom returns in shallow water, typically at the channel margins. However, green LiDAR does provide survey data that is an excellent complement to MBES, which is more effective at surveying the deeper portions of the channel. In some cases, the green LiDAR was able to provide data in areas that the MBES could not, often due to issues with navigating the survey boat in shallow water. Even where both MBES and green LiDAR mapped the river bottom, green LiDAR often provides more accurate data through a better angle of incidence and less shadowing than the MBES survey. For one MBES survey in 2013, the green LiDAR

KML-Based Access and Visualization of High Resolution LiDAR Topography

NASA Astrophysics Data System (ADS)

Crosby, C. J.; Blair, J. L.; Nandigam, V.; Memon, A.; Baru, C.; Arrowsmith, J. R.

2008-12-01

Over the past decade, there has been dramatic growth in the acquisition of LiDAR (Light Detection And Ranging) high-resolution topographic data for earth science studies. Capable of providing digital elevation models (DEMs) more than an order of magnitude higher resolution than those currently available, LiDAR data allow earth scientists to study the processes that contribute to landscape evolution at resolutions not previously possible yet essential for their appropriate representation. These datasets also have significant implications for earth science education and outreach because they provide an accurate representation of landforms and geologic hazards. Unfortunately, the massive volume of data produced by LiDAR mapping technology can be a barrier to their use. To make these data available to a larger user community, we have been exploring the use of Keyhole Markup Language (KML) and Google Earth to provide access to LiDAR data products and visualizations. LiDAR digital elevation models are typically delivered in a tiled format that lends itself well to a KML-based distribution system. For LiDAR datasets hosted in the GEON OpenTopography Portal (www.opentopography.org) we have developed KML files that show the extent of available LiDAR DEMs and provide direct access to the data products. Users interact with these KML files to explore the extent of the available data and are able to select DEMs that correspond to their area of interest. Selection of a tile loads a download that the user can then save locally for analysis in their software of choice. The GEON topography system also has tools available that allow users to generate custom DEMs from LiDAR point cloud data. This system is powerful because it enables users to access massive volumes of raw LiDAR data and to produce DEM products that are optimized to their science applications. We have developed a web service that converts the custom DEM models produced by the system to a hillshade that is delivered to

Threading on ADI Cast Iron, Developing Tools and Conditions

NASA Astrophysics Data System (ADS)

Elósegui, I.; de Lacalle, L. N. López

2011-01-01

The present work is focussed on the improvement of the design and performance of the taps used for making threaded holes in ADI (Austempered Ductile Iron). It is divided in two steps: a) The development of a method valid to compare the taps wear without reaching the end of their life, measuring the required torque to make one threaded hole, after having made previously a significant number of threaded holes. The tap wear causes some teeth geometrical changes, that supposes an increase in the required torque and axial force. b) The taps wear comparison method is open to apply on different PVD coated taps, AlTiN, AlCrSiN, AlTiSiN, , and to different geometries.

Anti-E1E2 antibodies status prior therapy favors direct-acting antiviral treatment efficacy.

PubMed

Virlogeux, Victor; Berthillon, Pascale; Bordes, Isabelle; Larrat, Sylvie; Crouy, Stéphanie; Scholtès, Caroline; Pradat, Pierre; Maynard, Marianne; Zoulim, Fabien; Leroy, Vincent; Chemin, Isabelle; Trépo, Christian; Petit, Marie-Anne

2018-03-15

Presence of anti-E1E2 antibodies was previously associated with spontaneous cure of hepatitis C virus (HCV) and predictive before treatment of a sustained virological response (SVR) to bi- or tri-therapy in naïve or experienced patients, regardless of HCV genotype. We investigated the impact of anti-E1E2 seroprevalence at baseline on treatment response in patients receiving direct-acting antiviral (DAA) therapy. We screened anti-E1E2 antibodies by ELISA in serum samples collected at treatment initiation for two groups of patients: 59 with SVR at the end of DAA treatment and 44 relapsers after DAA treatment. Nineteen patients received a combination of ribavirin (RBV) or PEG-interferon/ribavirin with sofosbuvir or daclatasvir and others received interferon-free treatment with DAA±RBV. HCV viral load was measured at different time points during treatment in a subgroup of patients. A significant association was observed between presence of anti-E1E2 and HCV viral load<6log10 prior treatment. Among patients with anti-E1E2 at baseline, 70% achieved SVR whereas among patients without anti-E1E2, only 45% achieved SVR. Conversely, 66% of patients experiencing DAA-failure were anti-E1E2 negative at baseline. In the multivariate analysis, presence of anti-E1E2 was significantly associated with SVR after adjustment on potential cofounders such as age, sex, fibrosis stage, prior HCV treatment and alanine aminotransferase (ALT) level. The presence of anti-E1E2 at treatment initiation is a predictive factor of SVR among patients treated with DAA and more likely among patients with low initial HCV viral load (<6log10). Absence of anti-E1E2 at baseline could predict DAA-treatment failure. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice.

PubMed

Rasmiena, Aliki A; Barlow, Christopher K; Stefanovic, Nada; Huynh, Kevin; Tan, Ricardo; Sharma, Arpeeta; Tull, Dedreia; de Haan, Judy B; Meikle, Peter J

2015-12-01

We previously reported a negative association of circulating plasmalogens (phospholipids with proposed atheroprotective properties) with coronary artery disease. Plasmalogen modulation was previously demonstrated in animals but its effect on atherosclerosis was unknown. We assessed the effect of plasmalogen enrichment on atherosclerosis of murine models with differing levels of oxidative stress. Six-week old ApoE- and ApoE/glutathione peroxidase-1 (GPx1)-deficient mice were fed a high-fat diet with/without 2% batyl alcohol (precursor to plasmalogen synthesis) for 12 weeks. Mass spectrometry analysis of lipids showed that batyl alcohol supplementation to ApoE- and ApoE/GPx1-deficient mice increased the total plasmalogen levels in both plasma and heart. Oxidation of plasmalogen in the treated mice was evident from increased level of plasmalogen oxidative by-product, sn-2 lysophospholipids. Atherosclerotic plaque in the aorta was reduced by 70% (P = 5.69E-07) and 69% (P = 2.00E-04) in treated ApoE- and ApoE/GPx1-deficient mice, respectively. A 40% reduction in plaque (P = 7.74E-03) was also seen in the aortic sinus of only the treated ApoE/GPx1-deficient mice. Only the treated ApoE/GPx1-deficient mice showed a decrease in VCAM-1 staining (-28%, P = 2.43E-02) in the aortic sinus and nitrotyrosine staining (-78%, P = 5.11E-06) in the aorta. Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE- and ApoE/GPx1-deficient mice, with a greater effect in the latter group. Plasmalogen enrichment may represent a viable therapeutic strategy to prevent atherosclerosis and reduce cardiovascular disease risk, particularly under conditions of elevated oxidative stress and inflammation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Evaluation of Tp-E Interval and Tp-E/QT Ratio in Patients with Aortic Stenosis.

PubMed

Yayla, Çağrı; Bilgin, Murat; Akboğa, Mehmet Kadri; Gayretli Yayla, Kadriye; Canpolat, Uğur; Dinç Asarcikli, Lale; Doğan, Mehmet; Turak, Osman; Çay, Serkan; Özeke, Özcan; Akyel, Ahmet; Yeter, Ekrem; Aydoğdu, Sinan

2016-05-01

The risk of syncope and sudden cardiac death due to ventricular arrhythmias increased in patients with aortic stenosis (AS). Recently, it was shown that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratio can be novel indicators for prediction of ventricular arrhythmias and mortality. We aimed to investigate the association between AS and ventricular repolarization using Tp-e interval and Tp-e/QT ratio. Totally, 105 patients with AS and 60 control subjects were enrolled to this study. The severity of AS was defined by transthoracic echocardiographic examination. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were significantly increased in parallel to the severity of AS (P < 0.001, P = 0.001, and P = 0.001, respectively). Also, it was shown that Tp-e/QTc ratio had significant positive correlation with mean aortic gradient (r = 0.192, P = 0.049). In multivariate logistic regression analysis, Tp-e/QTc ratio and left ventricular mass were found to be independent predictors of severe AS (P = 0.03 and P = 0.04, respectively). Our study showed that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were increased in patients with severe AS. Tp-e/QTc ratio and left ventricular mass were found as independent predictors of severe AS. © 2015 Wiley Periodicals, Inc.

They're M-e-e-elting!: An Investigation of Glacial Retreat in Antarctica

ERIC Educational Resources Information Center

Bugg, Samuel R., IV; Constible, Juanita; Kaput, Marianne; Lee, Richard E., Jr.

2007-01-01

In this article, the authors describe the mechanics of They're M-e-e-elting!, an activity wherein middle school students can simulate glacial retreat in Antarctica. They're M-e-e-elting! allows students to melt glaciers, change the water level and salinity of the Southern Ocean, and examine alterations to the Antarctic food web--all without…

Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation

PubMed Central

Peter, Daniel; Weber, Ramona; Köne, Carolin; Chung, Min-Yi; Ebertsch, Linda; Truffault, Vincent; Weichenrieder, Oliver; Igreja, Cátia; Izaurralde, Elisa

2015-01-01

The eIF4E-binding proteins (4E-BPs) are a diverse class of translation regulators that share a canonical eIF4E-binding motif (4E-BM) with eIF4G. Consequently, they compete with eIF4G for binding to eIF4E, thereby inhibiting translation initiation. Mextli (Mxt) is an unusual 4E-BP that promotes translation by also interacting with eIF3. Here we present the crystal structures of the eIF4E-binding regions of the Drosophila melanogaster (Dm) and Caenorhabditis elegans (Ce) Mxt proteins in complex with eIF4E in the cap-bound and cap-free states. The structures reveal unexpected evolutionary plasticity in the eIF4E-binding mode, with a classical bipartite interface for Ce Mxt and a novel tripartite interface for Dm Mxt. Both interfaces comprise a canonical helix and a noncanonical helix that engage the dorsal and lateral surfaces of eIF4E, respectively. Remarkably, Dm Mxt contains a C-terminal auxiliary helix that lies anti-parallel to the canonical helix on the eIF4E dorsal surface. In contrast to the eIF4G and Ce Mxt complexes, the Dm eIF4E–Mxt complexes are resistant to competition by bipartite 4E-BPs, suggesting that Dm Mxt can bind eIF4E when eIF4G binding is inhibited. Our results uncovered unexpected diversity in the binding modes of 4E-BPs, resulting in eIF4E complexes that display differential sensitivity to 4E-BP regulation. PMID:26294658

Student Chemical Engineering Reflective ePortfolios--ChE Student Perceptions of Learning from Reflective ePortfolio Creation

ERIC Educational Resources Information Center

Cherrstrom, Catherine A.; Raisor, Cindy; Fowler, Debra

2015-01-01

Engineering educators and employers value and prioritize communication skills, but developing and assessing such skills in engineering programs is challenging. Reflective ePortfolios provide opportunities to enhance communication skills. The purpose of this three-­year qualitative case study was to investigate the use of reflective ePortfolios in…

An Insight into E-Collections

ERIC Educational Resources Information Center

Albert, Angeline Sheba; Navaraj, A. Johnson

2006-01-01

The present paper gives a brief introduction about E-collections. It discusses the e-books, e-journals, utility, features, advantages and issues for the development of e-collections. E-books will offer a rich learning experience, reinforced with audio, video, 3D animation and collaborative learning tools. E-journals on the other hand are…

Production du baryon Sigma+ dans les collisions e+e- au LEP

NASA Astrophysics Data System (ADS)

Joly, Andre

Les mécanismes de production des baryons dans les interactions e+e- font l'objet de nombreuses études. De plus, les modes de production des baryons étranges semblent faire appel A des processus spécifiques, qui sont encore mal compris. Notre étude de la production des baryons Σ+ dans les interactions e+e- nous permet de formuler certaines remarques sur l'état des connaîssances acquises sur le sujet. Une methode de reconstruction originale et des critères de sélection spécifiques ont été développés afin d'identifier des baryons Σ+ de haute Energie ( ES+ > 5 GeV), partir de leur canal de désintégration en un proton et un π0 (S+-->p+p0 ). Trois mesures principales sont réalisées à partir de notre échantillon de baryons reconstruits. Le nombre mesuré de baryons Σ+ produits par événement e +e- à 91 GeV est de: =0.102+/-0.006(stat.) +/-0.008(syst.) +/-0.003(extrap.) où les erreurs sont dues à la statistique, aux systématiques et à la procédure d'extrapolation. Ce résultat est en accord avec ceux obtenus précédemment, mais avec des erreurs réduites. La section efficace différentielle en fonction de l'energie est mesurée et comparée aux prédictions des principaux générateurs Monte-Carlo (JETSET7.4(MOPS), JETSET7.4 et HERWIG5.9). A haute énergie, HERWIG ne semble pas reproduire les mesures, aussi bien que les deux versions de JETSET. Enfin, la position du maximum de la section efficace différentielle de production des baryons Σ+ en fonction de l'impulsion est mesurée. On trouve: overlinexoverlineS+=2.32+/- 0.47 Une étude spécifique du générateur JETSET7.4(MOPS) est réalisee, afin de mieux comprendre les mécanismes de production de l'étrangeté et du spin dans la production des baryons. Aucun générateur ne semble capable de décrire de manière simultanée la production du spin et de l'étrangeté.

Social media e-cigarette exposure and e-cigarette expectancies and use among young adults.

PubMed

Pokhrel, Pallav; Fagan, Pebbles; Herzog, Thaddeus A; Laestadius, Linnea; Buente, Wayne; Kawamoto, Crissy T; Lee, Hye-Ryeon; Unger, Jennifer B

2018-03-01

A vast majority of U.S. young adults use social media such as Facebook and Instagram daily. Research suggests that young adults are commonly exposed to e-cigarette-related marketing or user-generated content on the social media they use. Currently, however, there is limited empirical evidence as to how social media e-cigarette exposure is associated with e-cigarette use beliefs and behavior. In particular, limited evidence exists to support the proposition that social media e-cigarette exposure is uniquely associated with e-cigarette use, even after adjusting for the effects of e-cigarette use in young adults' in-person or 'offline' social networks. This study was conducted to test the hypotheses that 1) social media e-cigarette exposure is associated with e-cigarette use outcome expectancies and current e-cigarette use; and 2) the association between social media and e-cigarette use is linked via outcome expectancies. We collected cross-sectional data from a sample of 470 young adult college students in Hawaii. Hypotheses were tested by fitting a structural equation model to the data. The model accounted for the associations of demographic variables, cigarette smoking history, as well as e-cigarette use in individuals' actual social networks with expectancies and behavior. Results indicated that social media e-cigarette exposure was associated with current e-cigarette use indirectly through two of the four positive outcome expectancies examined, namely, positive "smoking" experience and positive sensory experience. We discuss the implications of the findings in the context of tobacco control efforts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

PubMed Central

Mortensen, Franziska; Schneider, Daniel; Barbic, Tanja; Sladewska-Marquardt, Anna; Kühnle, Simone; Marx, Andreas; Scheffner, Martin

2015-01-01

Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been associated with three different clinical pictures. Hijacking of E6AP by the E6 oncoprotein of distinct human papillomaviruses (HPV) contributes to the development of cervical cancer, whereas loss of E6AP expression or function is the cause of Angelman syndrome, a neurodevelopmental disorder, and increased expression of E6AP has been involved in autism spectrum disorders. Although these observations indicate that the activity of E6AP has to be tightly controlled, only little is known about how E6AP is regulated at the posttranslational level. Here, we provide evidence that the hydrophobic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, whereas it does not affect the catalytic properties of the isolated catalytic HECT domain of E6AP. Furthermore, we show that the HPV E6 oncoprotein rescues the disability of full-length E6AP to use a respective hydrophobic patch mutant of ubiquitin for ubiquitination and that it stimulates E6AP-mediated ubiquitination of Ring1B, a known substrate of E6AP, in vitro and in cells. Based on these data, we propose that E6AP exists in at least two different states, an active and a less active or latent one, and that the activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein. PMID:26216987

Guild-specific responses of avian species richness to LiDAR-derived habitat heterogeneity